[ { "uniprot_canonical_ac": "A0AAF6YXR7-1", "uniprot_ac": "A0AAF6YXR7", "uniprot_id": "A0AAF6YXR7_BOVIN", "mass": { "chemical_mass": 35965.0, "monoisotopic_mass": 35965.0 }, "refseq": {}, "gene_names": [ { "name": "TSPAN13", "type": "recommended", "evidence": [ { "id": "A0AAF6YXR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7" } ] } ], "protein_names": [ { "name": "Tetraspanin 13", "type": "synonym", "evidence": [ { "id": "A0AAF6YXR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN13", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7", "locus": { "chromosome": "4", "start_pos": 25302689, "end_pos": 25245149, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012805", "url": "https://www.ensembl.org/id/ENSBTAG00000012805" } ] } } ], "crossref": [ { "id": "A0AAF6YXR7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YXR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF203", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF203", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47027:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47027:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTNLDSILKSRDITLPTKVRLVKAMVFPVVMYGCENWTVKKAEHRRIDAFELWYWRRLLRVPWTARRSNQSILKEISPGYSLEGLMLKLKLQYFGHLMRRADSLEKTLMLGGIGGRRRRGRQRMRWLDGVTDSMDLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 318, "header": "tr|A0AAF6YXR7-1|A0AAF6YXR7_BOVIN Isoform 1 of Tetraspanin 13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=4 SV=1 CANONICAL=A0AAF6YXR7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY8/entry", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTENEKSTQL", "length": 187, "header": "tr|A0AAA9STY8-1|A0AAF6YXR7_BOVIN Computationally mapped isoform of Tetraspanin 13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=4 SV=1 CANONICAL=A0AAF6YXR7-1" }, "locus": { "chromosome": "4", "start_pos": 25278353, "end_pos": 25245330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105163.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105163.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087609.1" } ] } }, { "isoform_ac": "A0AAA9TLZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLZ4/entry", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTEVFLVAQLEKESACNAGDPSLIPGTEEPGGLQSVESQSQTQLSDLMLLRYTIHVKRFPHQFN", "length": 241, "header": "tr|A0AAA9TLZ4-1|A0AAF6YXR7_BOVIN Computationally mapped isoform of Tetraspanin 13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=4 SV=1 CANONICAL=A0AAF6YXR7-1" }, "locus": { "chromosome": "4", "start_pos": 25278050, "end_pos": 25245330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123012.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123012.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097321.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097321.1" } ] } }, { "isoform_ac": "A0AAA9TX27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX27/entry", "sequence": { "sequence": "MVCGGFACSKNCLCALNLLYTLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTETPWTVACQAPLTMEFPRQEYWIELPFPSSGDLPNPGIEPTSPALTGGFFTIEPPGEALVKH", "length": 241, "header": "tr|A0AAA9TX27-1|A0AAF6YXR7_BOVIN Computationally mapped isoform of Tetraspanin 13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=4 SV=1 CANONICAL=A0AAF6YXR7-1" }, "locus": { "chromosome": "4", "start_pos": 25302671, "end_pos": 25245330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102933.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102933.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101147.1" } ] } }, { "isoform_ac": "A0AAF6YXR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7/entry", "sequence": { "sequence": "MTNLDSILKSRDITLPTKVRLVKAMVFPVVMYGCENWTVKKAEHRRIDAFELWYWRRLLRVPWTARRSNQSILKEISPGYSLEGLMLKLKLQYFGHLMRRADSLEKTLMLGGIGGRRRRGRQRMRWLDGVTDSMDLVSLLLIGIAAWGIGFGLISSLRVVGVVIAVGIFLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQAQLLEVGWNNTASARDDIQRNLNCCGFRSFNPNDTCLASCVKSSHPCSPCAPIIGRYAGEVLRFVGGIGLFFSFTEILGVWLTYRYRNQKDPRANPSAFL", "length": 318, "header": "tr|A0AAF6YXR7-1|A0AAF6YXR7_BOVIN Isoform 1 of Tetraspanin 13 OS=Bos taurus OX=9913 GN=TSPAN13 PE=4 SV=1 CANONICAL=A0AAF6YXR7-1" }, "locus": { "chromosome": "4", "start_pos": 25282308, "end_pos": 25248950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017010.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017010.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017010.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017010.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YL67-1", "uniprot_ac": "A0AAF6YL67", "uniprot_id": "A0AAF6YL67_BOVIN", "mass": { "chemical_mass": 24168.0, "monoisotopic_mass": 24168.0 }, "refseq": { "ac": "XP_005208305", "name": "transmembrane protein 128 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208305" }, "gene_names": [ { "name": "TMEM128", "type": "recommended", "evidence": [ { "id": "A0AAF6YL67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67" } ] }, { "name": "TMEM128", "type": "synonym", "evidence": [ { "id": "XP_005208305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208305" } ] } ], "protein_names": [ { "name": "Transmembrane protein 128", "type": "synonym", "evidence": [ { "id": "A0AAF6YL67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 128 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208305" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL67", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM128", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67", "locus": { "chromosome": "6", "start_pos": 104869606, "end_pos": 104853830, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003652", "url": "https://www.ensembl.org/id/ENSBTAG00000003652" } ] } } ], "crossref": [ { "id": "A0AAF6YL67", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YL67", "database": "AlphaFoldDB", "categories": [] }, { "id": "513824", "url": "https://www.ncbi.nlm.nih.gov/gene/513824", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31134:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31134:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20479", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20479", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208305", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208305", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL67", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVLRAREQLRRRYLFPQDAEVPLEHEGYPRPETSTAVEKKEKPLPRLNIHSGFWILASIVVTYYVDFFQTVKENFHTSSWFLFGSALLLVSVSIAFYCIVYLEWYRGIEDYDIKYPALIPITTATFIVAGICQRWRSSIQSAKTRPGADCGSDHELLIAKFRLKLKKVGKTTRPFSFNVALWHVWSFFTPVLLFTQFMGVVMLTSLLG", "length": 209, "header": "tr|A0AAF6YL67-1|A0AAF6YL67_BOVIN Isoform 1 of Transmembrane protein 128 OS=Bos taurus OX=9913 GN=TMEM128 PE=4 SV=1 CANONICAL=A0AAF6YL67-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC2/entry", "sequence": { "sequence": "MDVLRAREQLRRRYLFPQDAEVPLEHEGYPRPETSTAVEKKEKPLPRLNIHSGFWILASIVVTYYVDFFQTVKENFHTSSWFLFGSALLLVSVSIAFYCIVYLEWYRGIEDYDIKYPALIPITTATFIVAGIWWKGVSVVNILPAKSTADAVVNTVCFCIYKVNGFLGRILTL", "length": 173, "header": "tr|A0AAA9SVC2-1|A0AAF6YL67_BOVIN Computationally mapped isoform of Transmembrane protein 128 OS=Bos taurus OX=9913 GN=TMEM128 PE=4 SV=1 CANONICAL=A0AAF6YL67-1" }, "locus": { "chromosome": "6", "start_pos": 104868602, "end_pos": 104853866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101070.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101070.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089280.1" } ] } }, { "isoform_ac": "A0AAA9TQ36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ36/entry", "sequence": { "sequence": "MPHSRPTLPVWVIFKGRRRTKYDIPRFGFNPETSTAVEKKEKPLPRLNIHSGFWILASIVVTYYVDFFQTVKENFHTSSWFLFGSALLLVSVSIAFYCIVYLEWYRGIEDYDIKYPALIPITTATFIVAGICFNVALWHVWSFFTPVLLFTQFMGVVMLTSLLG", "length": 164, "header": "tr|A0AAA9TQ36-1|A0AAF6YL67_BOVIN Computationally mapped isoform of Transmembrane protein 128 OS=Bos taurus OX=9913 GN=TMEM128 PE=4 SV=1 CANONICAL=A0AAF6YL67-1" }, "locus": { "chromosome": "6", "start_pos": 104866793, "end_pos": 104854522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125038.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125038.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099402.1" } ] } }, { "isoform_ac": "A0AAA9TYP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP5/entry", "sequence": { "sequence": "MDVLRAREQLRRRYLFPQDAEVPLEHEGYPRPETSTAVEKKEKPLPRLNIHSGFWILASIVVTYYVDFFQTVKENFHTSSQRWRSSIQSAKTRPGADCGSDHELLIAKFRLKLKKVGKTTRPFSFNVALWHVWSFFTPVLLFTQFMGVVMLTSLLG", "length": 156, "header": "tr|A0AAA9TYP5-1|A0AAF6YL67_BOVIN Computationally mapped isoform of Transmembrane protein 128 OS=Bos taurus OX=9913 GN=TMEM128 PE=4 SV=1 CANONICAL=A0AAF6YL67-1" }, "locus": { "chromosome": "6", "start_pos": 104866793, "end_pos": 104853866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126128.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126128.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102361.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102361.1" } ] } }, { "isoform_ac": "A0AAF6YL67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL67/entry", "sequence": { "sequence": "MDVLRAREQLRRRYLFPQDAEVPLEHEGYPRPETSTAVEKKEKPLPRLNIHSGFWILASIVVTYYVDFFQTVKENFHTSSWFLFGSALLLVSVSIAFYCIVYLEWYRGIEDYDIKYPALIPITTATFIVAGICQRWRSSIQSAKTRPGADCGSDHELLIAKFRLKLKKVGKTTRPFSFNVALWHVWSFFTPVLLFTQFMGVVMLTSLLG", "length": 209, "header": "tr|A0AAF6YL67-1|A0AAF6YL67_BOVIN Isoform 1 of Transmembrane protein 128 OS=Bos taurus OX=9913 GN=TMEM128 PE=4 SV=1 CANONICAL=A0AAF6YL67-1" }, "locus": { "chromosome": "6", "start_pos": 104866793, "end_pos": 104853866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004760.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004760.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004760.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004760.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YTE4-1", "uniprot_ac": "A0AAF6YTE4", "uniprot_id": "A0AAF6YTE4_BOVIN", "mass": { "chemical_mass": 20315.0, "monoisotopic_mass": 20315.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Large ribosomal subunit protein mL50", "type": "recommended", "evidence": [ { "id": "A0AAF6YTE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L50, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAF6YTE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4", "locus": {} } ], "crossref": [ { "id": "A0AAF6YTE4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YTE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31542", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31542", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31542:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31542:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "PPAPRPEGVTGNLPGTPLNYNSRHALRERWGAPCHGHGDRTTLPGVQKAREPGKEKQPVVAETVEEVKKEPILVCPPLRSQAYIPPKDLQSRLESHVKEVFGSSVPTSWQEISLEDVHMKFSFLARLADDLGHAVPNSRLHQMCRVRDVLDFYTVPVQDRSKFDELIASNLPPNLKITWGY", "length": 181, "header": "tr|A0AAF6YTE4-1|A0AAF6YTE4_BOVIN Isoform 1 of Large ribosomal subunit protein mL50 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YTE4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVP7/entry", "sequence": { "sequence": "MAALWVAGVGRKSLTVVASGAPRREFWSRLRKEKQPVVAETVEEVKKEPILVCPPLRSQAYIPPKDLQSRLESHVKEVFGSSVPTSWQEISLEDVHMKFSFLARLADDLGHAVPNSRLHQMCRCWRRLLRVPWTAERSNQSILKEISPEYSLEGLMLKLKLQYFGHLCEELTHLKRP", "length": 177, "header": "tr|A0AAA9SVP7-1|A0AAF6YTE4_BOVIN Computationally mapped isoform of Large ribosomal subunit protein mL50 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YTE4-1" }, "locus": { "chromosome": "8", "start_pos": 91120250, "end_pos": 91086331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107689.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107689.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090572.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090572.1" } ] } }, { "isoform_ac": "A0AAF6YTE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4/entry", "sequence": { "sequence": "PPAPRPEGVTGNLPGTPLNYNSRHALRERWGAPCHGHGDRTTLPGVQKAREPGKEKQPVVAETVEEVKKEPILVCPPLRSQAYIPPKDLQSRLESHVKEVFGSSVPTSWQEISLEDVHMKFSFLARLADDLGHAVPNSRLHQMCRVRDVLDFYTVPVQDRSKFDELIASNLPPNLKITWGY", "length": 181, "header": "tr|A0AAF6YTE4-1|A0AAF6YTE4_BOVIN Isoform 1 of Large ribosomal subunit protein mL50 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YTE4-1" }, "locus": { "chromosome": "8", "start_pos": 91120520, "end_pos": 91113481, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011798.4", "url": "https://www.ensembl.org/id/ENSBTAT00000011798.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011798.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011798.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4" } ], "pmid": "" }, { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMG7-1", "uniprot_ac": "A0AAF6DMG7", "uniprot_id": "A0AAF6DMG7_BOVIN", "mass": { "chemical_mass": 44696.0, "monoisotopic_mass": 44696.0 }, "refseq": {}, "gene_names": [ { "name": "GFRA3", "type": "recommended", "evidence": [ { "id": "A0AAF6DMG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ] } ], "protein_names": [ { "name": "GDNF family receptor alpha-3", "type": "recommended", "evidence": [ { "id": "A0AAF6DMG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWP5#function" }, { "database": "UniProtKB", "id": "ARBA00053965", "url": "https://www.uniprot.org/uniprotkb/ARBA00053965#function" }, { "database": "UniProtKB", "id": "A0AAA9T076", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T076#function" }, { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GFRA3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7", "locus": { "chromosome": "7", "start_pos": 49677964, "end_pos": 49695956, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005288", "url": "https://www.ensembl.org/id/ENSBTAG00000005288" } ] } } ], "crossref": [ { "id": "A0AAF6DMG7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "540009", "url": "https://www.ncbi.nlm.nih.gov/gene/540009", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10269:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10269:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T076", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T076", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T076-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T076-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARPQNPRPLPPALLLLLPLLLRAGDHLPTEGRFTNSCIQARRKCQADPTCNATYHYLNSCASSISTSSPAEEPLVPEDCMEAAQQLRNSSLMSCTCHRRMKNQATCLDIYWTIHPARSLGDYELDVSPYEDTVTRKPWKMNLSKLNMLIPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGSRCQRHTCQRQLRAFFEKASEPHSQGLLLCPCAPTDQGCGQRRRNTIAPSCALPSEAPNCLELRHVCVSDPLCRSRLADFQTHCHPMDILGTCATEQSRCLRAYMGLIGTALTPNFVSNINASVALSCTCRGSGNLQEECERLEESFSHNPCLIFLLSSVEAISAKMRFHSQLFSQDWAASTFSVMERQNKNPALRPQPWVPTLFSCTLTLILLSSLW", "length": 400, "header": "tr|A0AAF6DMG7-1|A0AAF6DMG7_BOVIN Isoform 1 of GDNF family receptor alpha-3 OS=Bos taurus OX=9913 GN=GFRA3 PE=3 SV=1 CANONICAL=A0AAF6DMG7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWP5/entry", "sequence": { "sequence": "MRKKKKMDATTENGDHLPTEGRFTNSCIQARRKCQADPTCNATYHYLNSCASSISTSSPAEEPLVPEDCMEAAQQLRNSSLMSCTCHRRMKNQATCLDIYWTIHPARSLGDYELDVSPYEDTVTRKPWKMNLSKLNMLIPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGSRCQRHTCQRQLRAFFEKASEPHSQGLLLCPCAPTDQGCGQRRRNTIAPSCALPSEAPNCLELRHVCVSDPLCRSRLADFQTHCHPMDILGTCATEQSRCLRAYMGLIGTALTPNFVSNINASVALSCTCRGSGNLQEECERLEESFSHNPCLMEAISAKMRFHSQLFSQDWAASTFSVMERQNKNPALRPQPWVPTLFSCTLTLILLSSLW", "length": 383, "header": "tr|A0AAA9SWP5-1|A0AAF6DMG7_BOVIN Computationally mapped isoform of GDNF family receptor alpha-3 OS=Bos taurus OX=9913 GN=GFRA3 PE=3 SV=1 CANONICAL=A0AAF6DMG7-1" }, "locus": { "chromosome": "7", "start_pos": 49688989, "end_pos": 49678689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127127.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127127.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090892.1" } ] } }, { "isoform_ac": "A0AAA9T076-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T076/entry", "sequence": { "sequence": "MARPQNPRPLPPALLLLLPLLLRAGDHLPTEGRFTNSCIQARRKCQADPTCNATYHYLNSCASSISTSSPAEEPLVPEDCMEAAQQLRNSSLMSCTCHRRMKNQATCLDIYWTIHPARSLDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGSRCQRHTCQRQLRAFFEKASEPHSQGLLLCPCAPTDQGCGQRRRNTIAPSCALPSEAPNCLELRHVCVSDPLCRSRLADFQTHCHPMDILGTCATEQSRCLRAYMGLIGTALTPNFVSNINASVALSCTCRGSGNLQEECERLEESFSHNPCLMEAISAKMRFHSQLFSQDWAASTFSVMERQNKNPALRPQPWVPTLFSCTLTLILLSSLW", "length": 363, "header": "tr|A0AAA9T076-1|A0AAF6DMG7_BOVIN Computationally mapped isoform of GDNF family receptor alpha-3 OS=Bos taurus OX=9913 GN=GFRA3 PE=3 SV=1 CANONICAL=A0AAF6DMG7-1" }, "locus": { "chromosome": "7", "start_pos": 49695901, "end_pos": 49678689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089793.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089793.1" } ] } }, { "isoform_ac": "A0AAF6DMG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7/entry", "sequence": { "sequence": "MARPQNPRPLPPALLLLLPLLLRAGDHLPTEGRFTNSCIQARRKCQADPTCNATYHYLNSCASSISTSSPAEEPLVPEDCMEAAQQLRNSSLMSCTCHRRMKNQATCLDIYWTIHPARSLGDYELDVSPYEDTVTRKPWKMNLSKLNMLIPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGSRCQRHTCQRQLRAFFEKASEPHSQGLLLCPCAPTDQGCGQRRRNTIAPSCALPSEAPNCLELRHVCVSDPLCRSRLADFQTHCHPMDILGTCATEQSRCLRAYMGLIGTALTPNFVSNINASVALSCTCRGSGNLQEECERLEESFSHNPCLIFLLSSVEAISAKMRFHSQLFSQDWAASTFSVMERQNKNPALRPQPWVPTLFSCTLTLILLSSLW", "length": 400, "header": "tr|A0AAF6DMG7-1|A0AAF6DMG7_BOVIN Isoform 1 of GDNF family receptor alpha-3 OS=Bos taurus OX=9913 GN=GFRA3 PE=3 SV=1 CANONICAL=A0AAF6DMG7-1" }, "locus": { "chromosome": "7", "start_pos": 49695901, "end_pos": 49678689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006958.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006958.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006958.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006958.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" }, { "name": "glial cell-derived neurotrophic factor receptor activity", "id": "GO:0016167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016167", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" }, { "name": "axon guidance receptor activity", "id": "GO:0008046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008046", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG7" }, { "id": "SM00907", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00907" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GDNF/GAS1", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 119, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUX3-1", "uniprot_ac": "A0AAF6YUX3", "uniprot_id": "A0AAF6YUX3_BOVIN", "mass": { "chemical_mass": 23927.0, "monoisotopic_mass": 23927.0 }, "refseq": {}, "gene_names": [ { "name": "GGCT", "type": "recommended", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ] } ], "protein_names": [ { "name": "Gamma-glutamylcyclotransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3/entry#names_and_taxonomy" } ] }, { "name": "4.3.2.9", "type": "synonym", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TPB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPB7#function" }, { "database": "UniProtKB", "id": "ARBA00059420", "url": "https://www.uniprot.org/uniprotkb/ARBA00059420#function" }, { "database": "UniProtKB", "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GGCT", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3", "locus": { "chromosome": "4", "start_pos": 65816128, "end_pos": 65782142, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010597", "url": "https://www.ensembl.org/id/ENSBTAG00000010597" } ] } } ], "crossref": [ { "id": "A0AAF6YUX3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06661", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06661", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR013024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12935:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12935:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "20505", "url": "https://www.rhea-db.org/rhea/20505", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SWV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMLMLHIVSHREMHNACAGVWWDMANFGCEDLRSQDGESFLYFAYGSNLLTERIHLRNPSAVFYSVARLQDFKLDFGNPQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKQEGVKSGMYVPIEVTVSTQEGKEITCRSYQMTNYESVPPSPQYKKVICMGAKENGLPLEYQKKLNSIEPNDYKGKVSEEIEDIIKKGEAKTH", "length": 211, "header": "tr|A0AAF6YUX3-1|A0AAF6YUX3_BOVIN Isoform 1 of Gamma-glutamylcyclotransferase OS=Bos taurus OX=9913 GN=GGCT PE=3 SV=1 CANONICAL=A0AAF6YUX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV2/entry", "sequence": { "sequence": "MANFGCEDLRSQDGESFLYFAYGSNLLTERIHLRNPSAVFYSVARLQDFKLDFGNPQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKSFAWAQKRMVCPWSTKRS", "length": 114, "header": "tr|A0AAA9SWV2-1|A0AAF6YUX3_BOVIN Computationally mapped isoform of Gamma-glutamylcyclotransferase OS=Bos taurus OX=9913 GN=GGCT PE=3 SV=1 CANONICAL=A0AAF6YUX3-1" }, "locus": { "chromosome": "4", "start_pos": 65815523, "end_pos": 65806804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100675.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100675.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089796.1" } ] } }, { "isoform_ac": "A0AAA9TPB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPB7/entry", "sequence": { "sequence": "MKNNCASSFWFCVSLGGTPRARGLASGKEASRISMWIRPAAGWTVEEGRVDRKLLCEDFKLDFGNPQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKQEGVKSGMYVPIEVTVSTQEGKEITCRSYQMTNYESVPPSPQYKKVICMGAKENGLPLEYQKKLNSIEPNDYKGKVSEEIEDIIKKGEAKTH", "length": 198, "header": "tr|A0AAA9TPB7-1|A0AAF6YUX3_BOVIN Computationally mapped isoform of Gamma-glutamylcyclotransferase OS=Bos taurus OX=9913 GN=GGCT PE=3 SV=1 CANONICAL=A0AAF6YUX3-1" }, "locus": { "chromosome": "4", "start_pos": 65815609, "end_pos": 65782341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096317.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096317.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098201.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098201.1" } ] } }, { "isoform_ac": "A0AAF6YUX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3/entry", "sequence": { "sequence": "MMLMLHIVSHREMHNACAGVWWDMANFGCEDLRSQDGESFLYFAYGSNLLTERIHLRNPSAVFYSVARLQDFKLDFGNPQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKQEGVKSGMYVPIEVTVSTQEGKEITCRSYQMTNYESVPPSPQYKKVICMGAKENGLPLEYQKKLNSIEPNDYKGKVSEEIEDIIKKGEAKTH", "length": 211, "header": "tr|A0AAF6YUX3-1|A0AAF6YUX3_BOVIN Isoform 1 of Gamma-glutamylcyclotransferase OS=Bos taurus OX=9913 GN=GGCT PE=3 SV=1 CANONICAL=A0AAF6YUX3-1" }, "locus": { "chromosome": "4", "start_pos": 65815609, "end_pos": 65804696, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014010.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014010.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014010.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014010.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "gamma-glutamylcyclotransferase activity", "id": "GO:0003839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003839", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "release of cytochrome c from mitochondria", "id": "GO:0001836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001836", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20505", "name": "", "equation": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LE4-1", "A0AAF6YUX3-1" ], "evidence": [ { "id": "20505", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20505" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YUX3", "gene_name": "GGCT", "activity": [ { "ec_number": "4.3.2.9", "activity": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid.", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ] }, { "ec_number": "4.3.2.9", "activity": "", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ] } ] }, { "uniprot_ac": "Q32LE4", "gene_name": "GGCT", "activity": [ { "ec_number": "4.3.2.9", "activity": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid.", "evidence": [ { "id": "Q32LE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ] }, { "ec_number": "4.3.2.9", "activity": "", "evidence": [ { "id": "Q32LE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.3.2.9", "ec_name": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid.", "evidence": [ { "id": "4.3.2.9", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.9" }, { "id": "4.3.2.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.3.2.9" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 113, "end_pos": 115 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YU99-1", "uniprot_ac": "A0AAF6YU99", "uniprot_id": "A0AAF6YU99_BOVIN", "mass": { "chemical_mass": 72989.0, "monoisotopic_mass": 72989.0 }, "refseq": {}, "gene_names": [ { "name": "MCMBP", "type": "recommended", "evidence": [ { "id": "A0AAF6YU99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ] } ], "protein_names": [ { "name": "Mini-chromosome maintenance complex-binding protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YU99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCMBP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99", "locus": { "chromosome": "26", "start_pos": 39947568, "end_pos": 39986119, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009877", "url": "https://www.ensembl.org/id/ENSBTAG00000009877" } ] } } ], "crossref": [ { "id": "A0AAF6YU99", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YU99", "database": "AlphaFoldDB", "categories": [] }, { "id": "514863", "url": "https://www.ncbi.nlm.nih.gov/gene/514863", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13489:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13489:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09739", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09739", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SXH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YU99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLPNCVPELLYCFERAAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMVQDMFDPEFYMGVYETVNRNTKARVLHFGKYRDVAECGPQQEVDLNSPRTTTLERQTFYCVPVPGESMWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDEDMDLQPNKQKDQHMGARQAGNVGGLQWCGEPKRLETEASSGQQLSSLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGILSVDPVLSILNNDERDASSLLDPMECTDMAEEQRVHSPPASLVPRIHVVLAQKLQHINPLLPACLNKEESKTCKFVSGFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRLQMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLMPPNMEEYMNSLLSAVLPSVLNKFRIYLTLLRFLDYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLIVARFLSLSAGQTTLSRERWLRAKQLESLRRARLQQQKCVNGNEL", "length": 640, "header": "tr|A0AAF6YU99-1|A0AAF6YU99_BOVIN Isoform 1 of Mini-chromosome maintenance complex-binding protein OS=Bos taurus OX=9913 GN=MCMBP PE=3 SV=1 CANONICAL=A0AAF6YU99-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH4/entry", "sequence": { "sequence": "MAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMVQDMFDPEFYMGVYETVNRNTKARVLHFGKYRDVAECGPQQEVDLNSPRTTTLERQTFYCVPVPGESMWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDEDMDLQPNKQKDQHMGARQAGNVGGLQWCGEPKRLETEASSGQQLSSLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGILSVDPVLSILNNDERDASSLLDPMECTDMAEEQRVHSPPASLVPRIHVVLAQKLQHINPLLPACLNKEESKTCKFVSGFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRLQMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLMPPNMEEYMNSLLSAVLPSVLNKFRIYLTLLRFLDYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLIVARFLSLSAGQTTLSRERWLRAKQLESLRRARLQQQKCVNGNEL", "length": 624, "header": "tr|A0AAA9SXH4-1|A0AAF6YU99_BOVIN Computationally mapped isoform of Mini-chromosome maintenance complex-binding protein OS=Bos taurus OX=9913 GN=MCMBP PE=3 SV=1 CANONICAL=A0AAF6YU99-1" }, "locus": { "chromosome": "26", "start_pos": 39971379, "end_pos": 39948572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103619.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103619.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090057.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090057.1" } ] } }, { "isoform_ac": "A0AAA9TWD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD9/entry", "sequence": { "sequence": "MPCGEDWLSHPLGIVQGFFAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMVQDMFDPEFYMGVYETVNRNTKARVLHFGKYRDVAECGPQQEVDLNSPRTTTLERQTFYCVPVPGESMWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDEDMDLQPNKQKDQHMGARQAGNVGGLQWCGEPKRLETEASSGQQLSSLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGILSVDPVLSILNNDERDASSLLDPMECTDMAEEQRVHSPPASLVPRIHVVLAQKLQHINPLLPACLNKEESKTCKFVSGFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRLQMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLMPPNMEEYMNSLLSAVLPSVLNKFRIYLTLLRFLDYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLIVARAGQTTLSRERWLRAKQLESLRRARLQQQKCVNGNEL", "length": 637, "header": "tr|A0AAA9TWD9-1|A0AAF6YU99_BOVIN Computationally mapped isoform of Mini-chromosome maintenance complex-binding protein OS=Bos taurus OX=9913 GN=MCMBP PE=3 SV=1 CANONICAL=A0AAF6YU99-1" }, "locus": { "chromosome": "26", "start_pos": 39985993, "end_pos": 39948572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116302.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116302.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100937.1" } ] } }, { "isoform_ac": "A0AAF6YU99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99/entry", "sequence": { "sequence": "MKLPNCVPELLYCFERAAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMVQDMFDPEFYMGVYETVNRNTKARVLHFGKYRDVAECGPQQEVDLNSPRTTTLERQTFYCVPVPGESMWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDEDMDLQPNKQKDQHMGARQAGNVGGLQWCGEPKRLETEASSGQQLSSLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGILSVDPVLSILNNDERDASSLLDPMECTDMAEEQRVHSPPASLVPRIHVVLAQKLQHINPLLPACLNKEESKTCKFVSGFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRLQMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLMPPNMEEYMNSLLSAVLPSVLNKFRIYLTLLRFLDYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLIVARFLSLSAGQTTLSRERWLRAKQLESLRRARLQQQKCVNGNEL", "length": 640, "header": "tr|A0AAF6YU99-1|A0AAF6YU99_BOVIN Isoform 1 of Mini-chromosome maintenance complex-binding protein OS=Bos taurus OX=9913 GN=MCMBP PE=3 SV=1 CANONICAL=A0AAF6YU99-1" }, "locus": { "chromosome": "26", "start_pos": 39976637, "end_pos": 39948572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013028.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013028.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013028.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013028.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "pmid": "" }, { "name": "MCM complex", "id": "GO:0042555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042555", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sister chromatid cohesion", "id": "GO:0007062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007062", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YU99", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU99" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 218, "end_pos": 220 }, { "start_pos": 390, "end_pos": 392 }, { "start_pos": 397, "end_pos": 399 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 473, "end_pos": 475 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLW8-1", "uniprot_ac": "A0AAF6DLW8", "uniprot_id": "A0AAF6DLW8_BOVIN", "mass": { "chemical_mass": 28420.0, "monoisotopic_mass": 28420.0 }, "refseq": {}, "gene_names": [ { "name": "NRADD", "type": "recommended", "evidence": [ { "id": "A0AAF6DLW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ] } ], "protein_names": [ { "name": "Death domain-containing membrane protein NRADD", "type": "recommended", "evidence": [ { "id": "A0AAF6DLW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8/entry#names_and_taxonomy" } ] }, { "name": "Neurotrophin receptor homolog-2", "type": "synonym", "evidence": [ { "id": "A0AAF6DLW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8/entry#names_and_taxonomy" } ] }, { "name": "Neurotrophin receptor-alike death domain protein", "type": "synonym", "evidence": [ { "id": "A0AAF6DLW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NRADD", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8", "locus": { "chromosome": "22", "start_pos": 52512055, "end_pos": 52515767, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022598", "url": "https://www.ensembl.org/id/ENSBTAG00000022598" } ] } } ], "crossref": [ { "id": "A0AAF6DLW8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "615855", "url": "https://www.ncbi.nlm.nih.gov/gene/615855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46605", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46605", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46605:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46605:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00531", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00531", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18422", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SXT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTVRAQTRLAGGDRTRFSATVDRGGAPGARKGRDWESPRMTSQSRRLLPGSKDKTRREQDREGVWAAAGGALAPSTSSPFSPEPPGASGSIIPVYCALLATVVLGLLAYVVFKCWRSRKHRQQLAKARTAELGALSRDQLHGDSSVFRDSPAGLEPCAPSQGPPPELGCQLYLHLPRQQQEEVERLLEVSGEPANGWRGLAGRLGYQAEAVETMARSPGPASALLRDWAVQEGSGATLRALADALAAMGREDVIRALSSPAEGCSVV", "length": 267, "header": "tr|A0AAF6DLW8-1|A0AAF6DLW8_BOVIN Isoform 1 of Death domain-containing membrane protein NRADD OS=Bos taurus OX=9913 GN=NRADD PE=4 SV=2 CANONICAL=A0AAF6DLW8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT7/entry", "sequence": { "sequence": "MWIRPGGSRTGKGCGQRQGEPWPPAPPPHSPLSPQGPQAASSLSTVPSWPPWSLVCLPTWSSSGRWSGHCPGVPLLPVWTPSQLAISVKAGAGWQVPPAPHSWRSRKHRQQLAKARTAELGALSRDQLHGDSSVFRDSPAGLEPCAPSQGPPPELGCQLYLHLPRQQQEEVERLLEVSGEPANGWRGLAGRLGYQAEAVETMARSPGPASALLRDWAVQEGSGATLRALADALAAMGREDVIRALSSPAEGCSVV", "length": 255, "header": "tr|A0AAA9SXT7-1|A0AAF6DLW8_BOVIN Computationally mapped isoform of Death domain-containing membrane protein NRADD OS=Bos taurus OX=9913 GN=NRADD PE=4 SV=1 CANONICAL=A0AAF6DLW8-1" }, "locus": { "chromosome": "22", "start_pos": 52514172, "end_pos": 52512368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131523.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131523.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090180.1" } ] } }, { "isoform_ac": "A0AAF6DLW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8/entry", "sequence": { "sequence": "MTVRAQTRLAGGDRTRFSATVDRGGAPGARKGRDWESPRMTSQSRRLLPGSKDKTRREQDREGVWAAAGGALAPSTSSPFSPEPPGASGSIIPVYCALLATVVLGLLAYVVFKCWRSRKHRQQLAKARTAELGALSRDQLHGDSSVFRDSPAGLEPCAPSQGPPPELGCQLYLHLPRQQQEEVERLLEVSGEPANGWRGLAGRLGYQAEAVETMARSPGPASALLRDWAVQEGSGATLRALADALAAMGREDVIRALSSPAEGCSVV", "length": 267, "header": "tr|A0AAF6DLW8-1|A0AAF6DLW8_BOVIN Isoform 1 of Death domain-containing membrane protein NRADD OS=Bos taurus OX=9913 GN=NRADD PE=4 SV=2 CANONICAL=A0AAF6DLW8-1" }, "locus": { "chromosome": "22", "start_pos": 52513628, "end_pos": 52512368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030613.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030613.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030588.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030588.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" }, { "name": "plasma membrane bounded cell projection", "id": "GO:0120025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120025", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" }, { "name": "nuclear envelope lumen", "id": "GO:0005641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005641", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW8" }, { "id": "PS50017", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50017" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Death", "eco_id": "ECO_0000259", "start_pos": 182, "end_pos": 261, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YKI3-1", "uniprot_ac": "A0AAF6YKI3", "uniprot_id": "A0AAF6YKI3_BOVIN", "mass": { "chemical_mass": 46240.0, "monoisotopic_mass": 46240.0 }, "refseq": {}, "gene_names": [ { "name": "DNAJB11", "type": "recommended", "evidence": [ { "id": "A0AAF6YKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily B member 11", "type": "recommended", "evidence": [ { "id": "A0AAF6YKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3/entry#names_and_taxonomy" } ] }, { "name": "ER-associated DNAJ", "type": "synonym", "evidence": [ { "id": "A0AAF6YKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3/entry#names_and_taxonomy" } ] }, { "name": "ER-associated Hsp40 co-chaperone", "type": "synonym", "evidence": [ { "id": "A0AAF6YKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3/entry#names_and_taxonomy" } ] }, { "name": "Endoplasmic reticulum DNA J domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6YKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3#function" }, { "database": "UniProtKB", "id": "ARBA00046194", "url": "https://www.uniprot.org/uniprotkb/ARBA00046194#function" }, { "database": "UniProtKB", "id": "A0AAA9SYN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJB11", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3", "locus": { "chromosome": "1", "start_pos": 80643691, "end_pos": 80665663, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003151", "url": "https://www.ensembl.org/id/ENSBTAG00000003151" } ] } } ], "crossref": [ { "id": "A0AAF6YKI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YKI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44298:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44298:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01556", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01556", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEPGTRPGCFLESRFSTQGSRKFSIAPQSCGQQLAAGAWAGRIPAAARLSDVSPSNWPGAAAEVPKPNWPPAPLRRRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHSIFERRGDDLYTNVTISLVESLVGFDMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLSEEAREGIKQLLKQGSVQKVYNGLQGY", "length": 412, "header": "tr|A0AAF6YKI3-1|A0AAF6YKI3_BOVIN Isoform 1 of DnaJ homolog subfamily B member 11 OS=Bos taurus OX=9913 GN=DNAJB11 PE=4 SV=1 CANONICAL=A0AAF6YKI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN7/entry", "sequence": { "sequence": "MAPQNLGTFCLLLLYLIGTVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHSIFERRGDDLYTNVTISLVESLVGFDMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLSEEAREGEGIMFTVQGKMRSALEGSEAWRVKAAMVA", "length": 367, "header": "tr|A0AAA9SYN7-1|A0AAF6YKI3_BOVIN Computationally mapped isoform of DnaJ homolog subfamily B member 11 OS=Bos taurus OX=9913 GN=DNAJB11 PE=4 SV=1 CANONICAL=A0AAF6YKI3-1" }, "locus": { "chromosome": "1", "start_pos": 80661759, "end_pos": 80644551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128793.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128793.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091569.1" } ] } }, { "isoform_ac": "A0AAF6YKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3/entry", "sequence": { "sequence": "MLEPGTRPGCFLESRFSTQGSRKFSIAPQSCGQQLAAGAWAGRIPAAARLSDVSPSNWPGAAAEVPKPNWPPAPLRRRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHSIFERRGDDLYTNVTISLVESLVGFDMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLSEEAREGIKQLLKQGSVQKVYNGLQGY", "length": 412, "header": "tr|A0AAF6YKI3-1|A0AAF6YKI3_BOVIN Isoform 1 of DnaJ homolog subfamily B member 11 OS=Bos taurus OX=9913 GN=DNAJB11 PE=4 SV=1 CANONICAL=A0AAF6YKI3-1" }, "locus": { "chromosome": "1", "start_pos": 80665588, "end_pos": 80644122, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004094.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004094.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004094.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004094.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" }, { "name": "protein folding chaperone complex", "id": "GO:0101031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" }, { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKI3" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 79, "end_pos": 144, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 315, "end_pos": 317 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YKG5-1", "uniprot_ac": "A0AAF6YKG5", "uniprot_id": "A0AAF6YKG5_BOVIN", "mass": { "chemical_mass": 50888.0, "monoisotopic_mass": 50888.0 }, "refseq": { "ac": "XP_059731428", "name": "transmembrane protein 183 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731428" }, "gene_names": [ { "name": "TMEM183A", "type": "recommended", "evidence": [ { "id": "A0AAF6YKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5" } ] }, { "name": "C1orf37", "type": "synonym", "evidence": [ { "id": "XP_059731428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731428" } ] }, { "name": "TMEM183A", "type": "synonym", "evidence": [ { "id": "XP_059731428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731428" } ] }, { "name": "TMEM183", "type": "synonym", "evidence": [ { "id": "XP_059731428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731428" } ] } ], "protein_names": [ { "name": "Transmembrane protein 183A", "type": "synonym", "evidence": [ { "id": "A0AAF6YKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 183 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731428" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM183A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5", "locus": { "chromosome": "16", "start_pos": 735553, "end_pos": 720213, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002874", "url": "https://www.ensembl.org/id/ENSBTAG00000002874" } ] } } ], "crossref": [ { "id": "A0AAF6YKG5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YKG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "534797", "url": "https://www.ncbi.nlm.nih.gov/gene/534797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20988", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20988", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20988:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20988:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731428", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731428", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SYP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARGPGPLTRPRPDTVAMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHREDLNGTGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRCQMTIEWSMLSSSATSPIAVRGSPLMMVLNWLLSTSTGWPLHSSSSRLSSPFQNILNHHCTVIGSSSGPNALLMLHYTLDASLPLRLRPESMEKLHCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTISVSTDMRHHRVRLVFQDYPVHGGQKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 451, "header": "tr|A0AAF6YKG5-1|A0AAF6YKG5_BOVIN Isoform 1 of Transmembrane protein 183A OS=Bos taurus OX=9913 GN=TMEM183A PE=4 SV=1 CANONICAL=A0AAF6YKG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP0/entry", "sequence": { "sequence": "MARGPGPLTRPRPDTVAMPKRGKRLKFRAQDACSGRVKSLCGLEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHREDLNGTGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLHCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTISVSTDMRHHRVRLVFQDYPVHGGQKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 346, "header": "tr|A0AAA9SYP0-1|A0AAF6YKG5_BOVIN Computationally mapped isoform of Transmembrane protein 183A OS=Bos taurus OX=9913 GN=TMEM183A PE=4 SV=1 CANONICAL=A0AAF6YKG5-1" }, "locus": { "chromosome": "16", "start_pos": 735039, "end_pos": 720400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099871.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099871.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090486.1" } ] } }, { "isoform_ac": "A0AAF6YKG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5/entry", "sequence": { "sequence": "MARGPGPLTRPRPDTVAMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHREDLNGTGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRCQMTIEWSMLSSSATSPIAVRGSPLMMVLNWLLSTSTGWPLHSSSSRLSSPFQNILNHHCTVIGSSSGPNALLMLHYTLDASLPLRLRPESMEKLHCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTISVSTDMRHHRVRLVFQDYPVHGGQKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA", "length": 451, "header": "tr|A0AAF6YKG5-1|A0AAF6YKG5_BOVIN Isoform 1 of Transmembrane protein 183A OS=Bos taurus OX=9913 GN=TMEM183A PE=4 SV=1 CANONICAL=A0AAF6YKG5-1" }, "locus": { "chromosome": "16", "start_pos": 735039, "end_pos": 720400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003726.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003726.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003726.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003726.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 152, "end_pos": 154 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YRC9-1", "uniprot_ac": "A0AAF6YRC9", "uniprot_id": "A0AAF6YRC9_BOVIN", "mass": { "chemical_mass": 33870.0, "monoisotopic_mass": 33870.0 }, "refseq": { "ac": "XP_059731975", "name": "translation initiation factor eIF2B subunit alpha isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731975" }, "gene_names": [ { "name": "EIF2B1", "type": "recommended", "evidence": [ { "id": "A0AAF6YRC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ] }, { "name": "EIF2B1", "type": "synonym", "evidence": [ { "id": "XP_059731975", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731975" } ] } ], "protein_names": [ { "name": "Translation initiation factor eIF2B subunit alpha", "type": "recommended", "evidence": [ { "id": "A0AAF6YRC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9/entry#names_and_taxonomy" } ] }, { "name": "eIF2B GDP-GTP exchange factor subunit alpha", "type": "synonym", "evidence": [ { "id": "A0AAF6YRC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9/entry#names_and_taxonomy" } ] }, { "name": "translation initiation factor eIF2B subunit alpha isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731975", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731975" } ] } ], "function": [ { "annotation": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9#function" }, { "database": "UniProtKB", "id": "ARBA00043898", "url": "https://www.uniprot.org/uniprotkb/ARBA00043898#function" }, { "database": "UniProtKB", "id": "A0AAA9TFR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR7#function" }, { "database": "UniProtKB", "id": "A0AAA9SZ19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ19#function" }, { "database": "UniProtKB", "id": "A0AAA9T9S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9S8#function" }, { "database": "UniProtKB", "id": "A0ABI0NIR2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIR2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF2B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9", "locus": { "chromosome": "17", "start_pos": 52061227, "end_pos": 52050286, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007269", "url": "https://www.ensembl.org/id/ENSBTAG00000007269" } ] } } ], "crossref": [ { "id": "A0AAF6YRC9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YRC9", "database": "AlphaFoldDB", "categories": [] }, { "id": "516670", "url": "https://www.ncbi.nlm.nih.gov/gene/516670", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45860:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45860:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731975", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731975", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NIR2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NIR2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNTELIEYFKSQIKEDPDMASAVAAIRTLLEYLRRDTGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGEIFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEAAVAAKKRFSVYITESQPDLSGQKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQTGQDLREEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL", "length": 305, "header": "tr|A0AAF6YRC9-1|A0AAF6YRC9_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit alpha OS=Bos taurus OX=9913 GN=EIF2B1 PE=3 SV=1 CANONICAL=A0AAF6YRC9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ19/entry", "sequence": { "sequence": "MDNTELIEYFKSQIKEDPDMASAVAAIRTLLEYLRRDTGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGEIFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEAAVAAKKRFSVYITESQPDLSGQVSFPVVMCPAVPLMSKLRMRLHCKSSQTKSPIFCQSASPFTLPVPAPGRKITEFGVGHSIA", "length": 223, "header": "tr|A0AAA9SZ19-1|A0AAF6YRC9_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit alpha OS=Bos taurus OX=9913 GN=EIF2B1 PE=3 SV=1 CANONICAL=A0AAF6YRC9-1" }, "locus": { "chromosome": "17", "start_pos": 52055735, "end_pos": 52050408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132864.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132864.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089533.1" } ] } }, { "isoform_ac": "A0AAA9T9S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9S8/entry", "sequence": { "sequence": "IKEDPDMASAVAAIRTLLEYLRRDTGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGEIFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEAAVAAKKRFSVYITESQPDLSGKKMAKALCHLNVPVTVVLDAAVGLELTRWPCAPKHRTSHFMLLQKVSSLYDSSH", "length": 202, "header": "tr|A0AAA9T9S8-1|A0AAF6YRC9_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit alpha OS=Bos taurus OX=9913 GN=EIF2B1 PE=3 SV=1 CANONICAL=A0AAF6YRC9-1" }, "locus": { "chromosome": "17", "start_pos": 52059603, "end_pos": 52051322, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095525.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095525.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095461.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095461.1" } ] } }, { "isoform_ac": "A0AAA9TFR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR7/entry", "sequence": { "sequence": "MKLIEYFKSQIKEDPDMASAVAAIRTLLEYLRRDTGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGEIFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEAAVAAKKRFSVYITESQPDLSGQKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQTGQDLREEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL", "length": 302, "header": "tr|A0AAA9TFR7-1|A0AAF6YRC9_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit alpha OS=Bos taurus OX=9913 GN=EIF2B1 PE=3 SV=1 CANONICAL=A0AAF6YRC9-1" }, "locus": { "chromosome": "17", "start_pos": 52060476, "end_pos": 52050717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092076.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092076.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095025.1" } ] } }, { "isoform_ac": "A0AAF6YRC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9/entry", "sequence": { "sequence": "MDNTELIEYFKSQIKEDPDMASAVAAIRTLLEYLRRDTGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGEIFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEAAVAAKKRFSVYITESQPDLSGQKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQTGQDLREEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL", "length": 305, "header": "tr|A0AAF6YRC9-1|A0AAF6YRC9_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit alpha OS=Bos taurus OX=9913 GN=EIF2B1 PE=3 SV=1 CANONICAL=A0AAF6YRC9-1" }, "locus": { "chromosome": "17", "start_pos": 52060476, "end_pos": 52050408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009560.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009560.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009560.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009560.5" } ] } }, { "isoform_ac": "A0ABI0NIR2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIR2/entry", "sequence": { "sequence": "ELIEYFKSQIKEDPDMASAVAAIRTLLEYLRRDTGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGEIFLRRISLSRNKIADLCHTFIKDGARILTHAYSRVVLRVLEAAVAAKKRFSVYITESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQTGQDLREEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL", "length": 301, "header": "tr|A0ABI0NIR2-1|A0ABI0NIR2_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit alpha OS=Bos taurus OX=9913 GN=EIF2B1 PE=3 SV=1 CANONICAL=A0AAF6YRC9-1" }, "locus": { "chromosome": "17", "start_pos": 52060476, "end_pos": 52051295, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139524.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139524.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104124.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104124.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 2B complex", "id": "GO:0005851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005851", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cytoplasmic translational initiation", "id": "GO:0002183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002183", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "oligodendrocyte development", "id": "GO:0014003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" }, { "name": "positive regulation of translational initiation", "id": "GO:0045948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045948", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YM68-1", "uniprot_ac": "A0AAF6YM68", "uniprot_id": "A0AAF6YM68_BOVIN", "mass": { "chemical_mass": 26681.0, "monoisotopic_mass": 26681.0 }, "refseq": {}, "gene_names": [ { "name": "SAT2", "type": "recommended", "evidence": [ { "id": "A0AAF6YM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68" } ] } ], "protein_names": [ { "name": "Spermidine/spermine N1-acetyltransferase family member 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAT2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68", "locus": { "chromosome": "19", "start_pos": 27342160, "end_pos": 27345975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004222", "url": "https://www.ensembl.org/id/ENSBTAG00000004222" } ] } } ], "crossref": [ { "id": "A0AAF6YM68", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YM68", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04301", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04301", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10545", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10545", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10545:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10545:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SZJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GPLRPTSLSAVARIGLQLPSPRSPHRLAPRRSRGFRGSEFVGPLKGPNCSSPLPTERKWGSWTSVPDVGEQAVPDVGEQDGFRDDPRSQGGRLWKYPEADSALRADGFGETPFYHCLVAEILSAPGEPQGPCVVGYGLYYFSYSTWKGRNIYLEDIYVKPEYRGQGIGSKIIKKVAEESEQCLLSQVALDKGCSQLRLAVLDWNKRAMDLYKALGAQDLTEAEGWHCFRFEGEAMRELAGK", "length": 241, "header": "tr|A0AAF6YM68-1|A0AAF6YM68_BOVIN Isoform 1 of Spermidine/spermine N1-acetyltransferase family member 2 OS=Bos taurus OX=9913 GN=SAT2 PE=3 SV=1 CANONICAL=A0AAF6YM68-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ0/entry", "sequence": { "sequence": "MAFVMIREAKEGDCGNILRLIRELAEYEKLSDQVKISEEALRADGFGETPFYHCLVAEILSAPGEPQGQGIGSKIIKKVAEVALDKGCSQLRLAVLDWNKRAMDLYKALGAQDLTEAEGWHCFRFEGEAMRELAGK", "length": 136, "header": "tr|A0AAA9SZJ0-1|A0AAF6YM68_BOVIN Computationally mapped isoform of Spermidine/spermine N1-acetyltransferase family member 2 OS=Bos taurus OX=9913 GN=SAT2 PE=3 SV=1 CANONICAL=A0AAF6YM68-1" }, "locus": { "chromosome": "19", "start_pos": 27345702, "end_pos": 27344525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088005.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088005.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089714.1" } ] } }, { "isoform_ac": "A0AAA9T1Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y9/entry", "sequence": { "sequence": "MAFVMIREAKEGDCGNILRLIRELAEYEKLSDQVKISEEALRADGFGETPFYHCLVAEILSAPGEPQGPCVVGYGLYYFSYSTWKGRNIYLEDIYVKPEYREPDILECEVKWALGSITMNKASGGGGIPVELFQILKDDAVKVLHSICQQIWKTQQWPSPRKSMPKNVQTTAQLYSSHMLAKECSKFSKPGFNST", "length": 195, "header": "tr|A0AAA9T1Y9-1|A0AAF6YM68_BOVIN Computationally mapped isoform of Spermidine/spermine N1-acetyltransferase family member 2 OS=Bos taurus OX=9913 GN=SAT2 PE=3 SV=1 CANONICAL=A0AAF6YM68-1" }, "locus": { "chromosome": "19", "start_pos": 27345702, "end_pos": 27342626, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134910.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134910.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090606.1" } ] } }, { "isoform_ac": "A0AAF6YM68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68/entry", "sequence": { "sequence": "GPLRPTSLSAVARIGLQLPSPRSPHRLAPRRSRGFRGSEFVGPLKGPNCSSPLPTERKWGSWTSVPDVGEQAVPDVGEQDGFRDDPRSQGGRLWKYPEADSALRADGFGETPFYHCLVAEILSAPGEPQGPCVVGYGLYYFSYSTWKGRNIYLEDIYVKPEYRGQGIGSKIIKKVAEESEQCLLSQVALDKGCSQLRLAVLDWNKRAMDLYKALGAQDLTEAEGWHCFRFEGEAMRELAGK", "length": 241, "header": "tr|A0AAF6YM68-1|A0AAF6YM68_BOVIN Isoform 1 of Spermidine/spermine N1-acetyltransferase family member 2 OS=Bos taurus OX=9913 GN=SAT2 PE=3 SV=1 CANONICAL=A0AAF6YM68-1" }, "locus": { "chromosome": "19", "start_pos": 27345940, "end_pos": 27344525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005531.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005531.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005531.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005531.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "acyltransferase activity, transferring groups other than amino-acyl groups", "id": "GO:0016747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016747", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM68" }, { "id": "PS51186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "N-acetyltransferase", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 237, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YLD8-1", "uniprot_ac": "A0AAF6YLD8", "uniprot_id": "A0AAF6YLD8_BOVIN", "mass": { "chemical_mass": 49722.0, "monoisotopic_mass": 49722.0 }, "refseq": {}, "gene_names": [ { "name": "BMP4", "type": "recommended", "evidence": [ { "id": "A0AAF6YLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ] } ], "protein_names": [ { "name": "Bone morphogenetic protein 4", "type": "recommended", "evidence": [ { "id": "A0AAF6YLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BMP4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8", "locus": { "chromosome": "10", "start_pos": 66518536, "end_pos": 66532577, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003835", "url": "https://www.ensembl.org/id/ENSBTAG00000003835" } ] } } ], "crossref": [ { "id": "A0AAF6YLD8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YLD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19391", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19391", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848:SF165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848:SF165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00688", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00688", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SZL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSHSVVPSRATHCRSSSEPFQQVCSRLAVKNHGLLLYALFSVILLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQIQGIGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWDQGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHPQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR", "length": 437, "header": "tr|A0AAF6YLD8-1|A0AAF6YLD8_BOVIN Isoform 1 of Bone morphogenetic protein 4 OS=Bos taurus OX=9913 GN=BMP4 PE=3 SV=1 CANONICAL=A0AAF6YLD8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZL8/entry", "sequence": { "sequence": "MDCYYMPCFLDTMIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQIQGIGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWDQGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHPQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR", "length": 421, "header": "tr|A0AAA9SZL8-1|A0AAF6YLD8_BOVIN Computationally mapped isoform of Bone morphogenetic protein 4 OS=Bos taurus OX=9913 GN=BMP4 PE=3 SV=1 CANONICAL=A0AAF6YLD8-1" }, "locus": { "chromosome": "10", "start_pos": 66522106, "end_pos": 66518817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103625.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103625.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090868.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090868.1" } ] } }, { "isoform_ac": "A0AAF6YLD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8/entry", "sequence": { "sequence": "MRSHSVVPSRATHCRSSSEPFQQVCSRLAVKNHGLLLYALFSVILLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQIQGIGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWDQGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHPQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR", "length": 437, "header": "tr|A0AAF6YLD8-1|A0AAF6YLD8_BOVIN Isoform 1 of Bone morphogenetic protein 4 OS=Bos taurus OX=9913 GN=BMP4 PE=3 SV=1 CANONICAL=A0AAF6YLD8-1" }, "locus": { "chromosome": "10", "start_pos": 66523187, "end_pos": 66518817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004992.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004992.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004992.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004992.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 72, "go_terms": [ { "name": "regulation of branching involved in ureteric bud morphogenesis", "id": "GO:0090189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090189", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of epithelial cell differentiation", "id": "GO:0030858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030858", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "cellular response to BMP stimulus", "id": "GO:0071773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071773", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "cartilage development", "id": "GO:0051216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "regulation of MAPK cascade", "id": "GO:0043408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of ossification", "id": "GO:0045778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045778", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "epithelial tube branching involved in lung morphogenesis", "id": "GO:0060441", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060441", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of multicellular organismal process", "id": "GO:0051241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051241", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of odontoblast differentiation", "id": "GO:1901331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901331", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "stem cell differentiation", "id": "GO:0048863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048863", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of collagen biosynthetic process", "id": "GO:0032967", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032967", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of smooth muscle cell proliferation", "id": "GO:0048661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048661", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of thymocyte apoptotic process", "id": "GO:0070244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070244", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell proliferation", "id": "GO:0001938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001938", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of bone mineralization", "id": "GO:0030501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030501", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "id": "GO:0002043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002043", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of BMP signaling pathway", "id": "GO:0030513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030513", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell differentiation", "id": "GO:0045603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045603", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of epidermal cell differentiation", "id": "GO:0045606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045606", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "odontogenesis", "id": "GO:0042476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042476", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "coronary vasculature development", "id": "GO:0060976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060976", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of p38MAPK cascade", "id": "GO:1900745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900745", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of osteoblast differentiation", "id": "GO:0045669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045669", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "cardiac muscle cell differentiation", "id": "GO:0055007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055007", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "osteoblast differentiation", "id": "GO:0001649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "chondrocyte differentiation", "id": "GO:0002062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002062", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of epithelial to mesenchymal transition", "id": "GO:0010718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010718", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of mitotic nuclear division", "id": "GO:0045839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045839", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of immature T cell proliferation in thymus", "id": "GO:0033088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033088", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "branching involved in ureteric bud morphogenesis", "id": "GO:0001658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001658", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "lymphoid progenitor cell differentiation", "id": "GO:0002320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002320", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "lung vasculature development", "id": "GO:0060426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060426", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "nephric duct formation", "id": "GO:0072179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072179", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "ureter morphogenesis", "id": "GO:0072197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "secondary heart field specification", "id": "GO:0003139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "endochondral ossification", "id": "GO:0001958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001958", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "type B pancreatic cell development", "id": "GO:0003323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003323", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of SMAD protein signal transduction", "id": "GO:0060391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060391", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of glomerular mesangial cell proliferation", "id": "GO:0072125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072125", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", "id": "GO:1905312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905312", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "outflow tract septum morphogenesis", "id": "GO:0003148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003148", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "membranous septum morphogenesis", "id": "GO:0003149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003149", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "aortic valve morphogenesis", "id": "GO:0003180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003180", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "pulmonary valve morphogenesis", "id": "GO:0003184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003184", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "endocardial cushion development", "id": "GO:0003197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "regulation of cell fate commitment", "id": "GO:0010453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010453", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "monocyte differentiation", "id": "GO:0030224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030224", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "macrophage differentiation", "id": "GO:0030225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030225", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "tendon cell differentiation", "id": "GO:0035990", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035990", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "deltoid tuberosity development", "id": "GO:0035993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035993", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "intermediate mesodermal cell differentiation", "id": "GO:0048392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048392", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "smooth muscle tissue development", "id": "GO:0048745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048745", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle fiber development", "id": "GO:0055020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of branching involved in lung morphogenesis", "id": "GO:0061047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061047", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "pharyngeal arch artery morphogenesis", "id": "GO:0061626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061626", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "glomerular capillary formation", "id": "GO:0072104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072104", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of mesenchymal cell proliferation involved in ureter development", "id": "GO:0072200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072200", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of branching involved in ureteric bud morphogenesis", "id": "GO:0090191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090191", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of glomerulus development", "id": "GO:0090194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090194", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of miRNA transcription", "id": "GO:1902895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902895", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of metanephric S-shaped body morphogenesis", "id": "GO:2000005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of metanephric comma-shaped body morphogenesis", "id": "GO:2000007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000007", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "positive regulation of primary miRNA processing", "id": "GO:2000636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000636", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "heart induction", "id": "GO:0003129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003129", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "chemoattractant activity", "id": "GO:0042056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042056", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "BMP receptor binding", "id": "GO:0070700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070700", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" }, { "name": "co-receptor binding", "id": "GO:0039706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039706", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLD8" }, { "id": "PS51362", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51362" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TGF-beta family profile", "eco_id": "ECO_0000259", "start_pos": 315, "end_pos": 437, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 237, "end_pos": 239 }, { "start_pos": 379, "end_pos": 381 }, { "start_pos": 394, "end_pos": 396 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJV2-1", "uniprot_ac": "A0AAF6YJV2", "uniprot_id": "A0AAF6YJV2_BOVIN", "mass": { "chemical_mass": 53196.0, "monoisotopic_mass": 53196.0 }, "refseq": {}, "gene_names": [ { "name": "GNAI1", "type": "recommended", "evidence": [ { "id": "A0AAF6YJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ] } ], "protein_names": [ { "name": "Guanine nucleotide-binding protein G(i) subunit alpha-1", "type": "recommended", "evidence": [ { "id": "A0AAF6YJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2/entry#names_and_taxonomy" } ] }, { "name": "Adenylate cyclase-inhibiting G alpha protein", "type": "synonym", "evidence": [ { "id": "A0AAF6YJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNAI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2", "locus": { "chromosome": "4", "start_pos": 40955834, "end_pos": 41231777, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002714", "url": "https://www.ensembl.org/id/ENSBTAG00000002714" } ] } } ], "crossref": [ { "id": "A0AAF6YJV2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00066", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00066", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218:SF227", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218:SF227", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218:SF359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218:SF359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00503", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00503", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T3M3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLHREDSWHIDLFCFLHGSIPEPARSISHRHEGQLTRVCILKTLARPPELGMLKRPGLVFFRFPTLAALPPAPQGAGPHTSLGVSKREEIITLSSRKPARRTSRERQPAFAPGTMGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF", "length": 469, "header": "tr|A0AAF6YJV2-1|A0AAF6YJV2_BOVIN Isoform 1 of Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Bos taurus OX=9913 GN=GNAI1 PE=3 SV=1 CANONICAL=A0AAF6YJV2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M3/entry", "sequence": { "sequence": "MGFPRHEHWTGLPFPSSGNLSDPGIEPMSLVSPSLAGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF", "length": 351, "header": "tr|A0AAA9T3M3-1|A0AAF6YJV2_BOVIN Computationally mapped isoform of Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Bos taurus OX=9913 GN=GNAI1 PE=3 SV=1 CANONICAL=A0AAF6YJV2-1" }, "locus": { "chromosome": "4", "start_pos": 41045750, "end_pos": 40957755, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134892.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134892.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090292.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090292.1" } ] } }, { "isoform_ac": "A0AAA9TJN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJN6/entry", "sequence": { "sequence": "MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGESTGRNEARESQSRPKSTAPAASRTSAVRIHFIIFALEAKQRLLQSV", "length": 339, "header": "tr|A0AAA9TJN6-1|A0AAF6YJV2_BOVIN Computationally mapped isoform of Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Bos taurus OX=9913 GN=GNAI1 PE=3 SV=1 CANONICAL=A0AAF6YJV2-1" }, "locus": { "chromosome": "4", "start_pos": 41060775, "end_pos": 40966060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123177.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123177.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098568.1" } ] } }, { "isoform_ac": "A0AAA9TV20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV20/entry", "sequence": { "sequence": "MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGQHYLLPKPGKYVTRKFSSVTQSCPTLRDPMDHSTQGLPVHHQLLESAQTHLH", "length": 344, "header": "tr|A0AAA9TV20-1|A0AAF6YJV2_BOVIN Computationally mapped isoform of Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Bos taurus OX=9913 GN=GNAI1 PE=3 SV=1 CANONICAL=A0AAF6YJV2-1" }, "locus": { "chromosome": "4", "start_pos": 41060775, "end_pos": 40962891, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091029.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091029.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102204.1" } ] } }, { "isoform_ac": "A0AAA9TWG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWG6/entry", "sequence": { "sequence": "MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARAAQTHMKRQLRTFSVSLKTSIRERTQRKYTPTSRAPRTPRTCSSSLMP", "length": 148, "header": "tr|A0AAA9TWG6-1|A0AAF6YJV2_BOVIN Computationally mapped isoform of Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Bos taurus OX=9913 GN=GNAI1 PE=3 SV=1 CANONICAL=A0AAF6YJV2-1" }, "locus": { "chromosome": "4", "start_pos": 41060775, "end_pos": 40957802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101524.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101524.1" } ] } }, { "isoform_ac": "A0AAF6YJV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2/entry", "sequence": { "sequence": "MDLHREDSWHIDLFCFLHGSIPEPARSISHRHEGQLTRVCILKTLARPPELGMLKRPGLVFFRFPTLAALPPAPQGAGPHTSLGVSKREEIITLSSRKPARRTSRERQPAFAPGTMGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF", "length": 469, "header": "tr|A0AAF6YJV2-1|A0AAF6YJV2_BOVIN Isoform 1 of Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Bos taurus OX=9913 GN=GNAI1 PE=3 SV=1 CANONICAL=A0AAF6YJV2-1" }, "locus": { "chromosome": "4", "start_pos": 41184597, "end_pos": 40957755, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003515.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003515.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003515.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003515.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "G-protein beta/gamma-subunit complex binding", "id": "GO:0031683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031683", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "D2 dopamine receptor binding", "id": "GO:0031749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031749", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "adenylate cyclase inhibitor activity", "id": "GO:0010855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010855", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "heterotrimeric G-protein complex", "id": "GO:0005834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005834", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "regulation of eating behavior", "id": "GO:1903998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903998", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "chemokine-mediated signaling pathway", "id": "GO:0070098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070098", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "positive regulation of cholesterol biosynthetic process", "id": "GO:0045542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "adenylate cyclase-inhibiting serotonin receptor signaling pathway", "id": "GO:0007198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "positive regulation of protein localization to cell cortex", "id": "GO:1904778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904778", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "regulation of mitotic spindle organization", "id": "GO:0060236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060236", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "T cell migration", "id": "GO:0072678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072678", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "mast cell degranulation", "id": "GO:0043303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043303", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" }, { "name": "response to prostaglandin E", "id": "GO:0034695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034695", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAF6YJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" }, { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 162, "amino_acid": "Ser", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 162, "end_pos": 162, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 178, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 178, "end_pos": 178, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 181, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 181, "end_pos": 181, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJV2" }, { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 296, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 296, "end_pos": 296, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 44, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 44, "end_pos": 44, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 47, "amino_acid": "Arg", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 47, "end_pos": 47, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 256, "end_pos": 258 }, { "start_pos": 264, "end_pos": 266 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM43-1", "uniprot_ac": "A0AAF6DM43", "uniprot_id": "A0AAF6DM43_BOVIN", "mass": { "chemical_mass": 63721.0, "monoisotopic_mass": 63721.0 }, "refseq": { "ac": "XP_024833932", "name": "centromere protein T isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833932" }, "gene_names": [ { "name": "CENPT", "type": "recommended", "evidence": [ { "id": "A0AAF6DM43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ] }, { "name": "CENPT", "type": "synonym", "evidence": [ { "id": "XP_024833932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833932" } ] } ], "protein_names": [ { "name": "Centromere protein T", "type": "recommended", "evidence": [ { "id": "A0AAF6DM43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43/entry#names_and_taxonomy" } ] }, { "name": "centromere protein T isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024833932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833932" } ] } ], "function": [ { "annotation": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43#function" }, { "database": "UniProtKB", "id": "ARBA00045461", "url": "https://www.uniprot.org/uniprotkb/ARBA00045461#function" }, { "database": "UniProtKB", "id": "A0AAA9TC71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC71#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPT", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43", "locus": { "chromosome": "18", "start_pos": 35338638, "end_pos": 35344700, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006404", "url": "https://www.ensembl.org/id/ENSBTAG00000006404" } ] } } ], "crossref": [ { "id": "A0AAF6DM43", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM43", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22920", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22920", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513195", "url": "https://www.ncbi.nlm.nih.gov/gene/513195", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46904", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46904", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46904:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46904:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15511", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15511", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833932", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833932", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3S2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYNFSPDSEPTTRTLLRQVLDTAVPRTPRRARSTRSGCWSLHSAQRDLLETPSSRRQRSQTKMTARRRSHTATSVDRLARVQASGHLEEQTPRTLLKNIILTAPESSIVMPEAVVKLVPSPQVVQPSRRKSSRGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSEFQQGMDWGHLSQEPRENADASSLTSSLNLTFAMPLQPQSVKRPGLARRPPTRRVVDVGTFLQDLRDTSLTVAPPGESHRTPVATVPMDTVLEDTQPFSQPLAGHSPSVHHSLPCPSPSGAKEVEGAASRRTRSSGPGLQNSYSGPGKPAQLLARKMEEVEAIAMGLPNTSSVSGEDGIEPLQNGVGEEAEESMEESMSVREVEKAAEEQGSARAEEPEGHTEVAAAAGSLGAIEAKEPEGSSEDEDTSASPELPPSTPEFLRTRRLQFPEPAPPPSTAVLPSELPKHLSARIPPRPRIPGSRPRQDPNKAGLNHYAKLFSFYAKMPMEKKAEEMVEKCLDKYFQHLCNDLEVFAAHAGRKTVRPEDLELLLRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAFSGNSVFPSQ", "length": 581, "header": "tr|A0AAF6DM43-1|A0AAF6DM43_BOVIN Isoform 1 of Centromere protein T OS=Bos taurus OX=9913 GN=CENPT PE=3 SV=1 CANONICAL=A0AAF6DM43-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3S2/entry", "sequence": { "sequence": "MAYNFSPDSEPTTRTLLRQVLDTAVPRTPRRARSTRSGAQRDLLETPSSRRQRSQTKMTARRRSHTATLQNLPL", "length": 74, "header": "tr|A0AAA9T3S2-1|A0AAF6DM43_BOVIN Computationally mapped isoform of Centromere protein T OS=Bos taurus OX=9913 GN=CENPT PE=3 SV=1 CANONICAL=A0AAF6DM43-1" }, "locus": { "chromosome": "18", "start_pos": 35344501, "end_pos": 35342575, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106489.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106489.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091140.1" } ] } }, { "isoform_ac": "A0AAA9TC71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC71/entry", "sequence": { "sequence": "MAYNFSPDSEPTTRTLLRQVLDTAVPRTPRRARSTRSGAQRDLLETPSSRRQRSQTKMTARRRSHTATSVDRLARVQASGHLEEQTPRTLLKNIILTAPESSIVMPEAVVKLVPSPQVVQPSRRKSSRGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSEFQQGMDWGHLSQEPRENADASSLTSSLNLTFAMPLQPQSVKRPGLARRPPTRRVVDVGTFLQDLRDTSLTVAPPDSGPGKPAQLLARKMEEVEAIAMGLPNTSSVSGEDGIEPLQNGVGEEAEESMEESMSVREVEKAAEEQGSARAEEPEGHTEVAAAAGSLGAIEAKEPEGSSEDEDTSASPELPPSTPEFLRTRRLQFPEPAPPPSTAVLPSELPKHLSARIPPRPRIPGSRPRQDPNKAGLNHYAKLFSFYAKMPMEKKAEEMVEKCLDKYFQHLCNDLEVFAAHAGRKTVRPEDLELLLRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAFSGNSVFPSQ", "length": 508, "header": "tr|A0AAA9TC71-1|A0AAF6DM43_BOVIN Computationally mapped isoform of Centromere protein T OS=Bos taurus OX=9913 GN=CENPT PE=3 SV=1 CANONICAL=A0AAF6DM43-1" }, "locus": { "chromosome": "18", "start_pos": 35344501, "end_pos": 35338745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130495.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130495.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094328.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094328.1" } ] } }, { "isoform_ac": "A0AAF6DM43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43/entry", "sequence": { "sequence": "MAYNFSPDSEPTTRTLLRQVLDTAVPRTPRRARSTRSGCWSLHSAQRDLLETPSSRRQRSQTKMTARRRSHTATSVDRLARVQASGHLEEQTPRTLLKNIILTAPESSIVMPEAVVKLVPSPQVVQPSRRKSSRGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSEFQQGMDWGHLSQEPRENADASSLTSSLNLTFAMPLQPQSVKRPGLARRPPTRRVVDVGTFLQDLRDTSLTVAPPGESHRTPVATVPMDTVLEDTQPFSQPLAGHSPSVHHSLPCPSPSGAKEVEGAASRRTRSSGPGLQNSYSGPGKPAQLLARKMEEVEAIAMGLPNTSSVSGEDGIEPLQNGVGEEAEESMEESMSVREVEKAAEEQGSARAEEPEGHTEVAAAAGSLGAIEAKEPEGSSEDEDTSASPELPPSTPEFLRTRRLQFPEPAPPPSTAVLPSELPKHLSARIPPRPRIPGSRPRQDPNKAGLNHYAKLFSFYAKMPMEKKAEEMVEKCLDKYFQHLCNDLEVFAAHAGRKTVRPEDLELLLRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAFSGNSVFPSQ", "length": 581, "header": "tr|A0AAF6DM43-1|A0AAF6DM43_BOVIN Isoform 1 of Centromere protein T OS=Bos taurus OX=9913 GN=CENPT PE=3 SV=1 CANONICAL=A0AAF6DM43-1" }, "locus": { "chromosome": "18", "start_pos": 35344501, "end_pos": 35338745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008396.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008396.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008396.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008396.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "kinetochore assembly", "id": "GO:0051382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051382", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" }, { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" }, { "id": "PF15511", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15511" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CENP-T/Histone H4 histone fold", "eco_id": "ECO_0000259", "start_pos": 475, "end_pos": 571, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM43" }, { "id": "PF16171", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centromere kinetochore component CENP-T N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 435, "start_aa": "Met", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMC6-1", "uniprot_ac": "A0AAF6DMC6", "uniprot_id": "A0AAF6DMC6_BOVIN", "mass": { "chemical_mass": 81118.0, "monoisotopic_mass": 81118.0 }, "refseq": { "ac": "XP_005216949", "name": "protein-associating with the carboxyl-terminal domain of ezrin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216949" }, "gene_names": [ { "name": "SCYL3", "type": "recommended", "evidence": [ { "id": "A0AAF6DMC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ] }, { "name": "SCYL3", "type": "synonym", "evidence": [ { "id": "XP_005216949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216949" } ] } ], "protein_names": [ { "name": "Protein-associating with the carboxyl-terminal domain of ezrin", "type": "recommended", "evidence": [ { "id": "A0AAF6DMC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6/entry#names_and_taxonomy" } ] }, { "name": "Ezrin-binding protein PACE-1", "type": "synonym", "evidence": [ { "id": "A0AAF6DMC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6/entry#names_and_taxonomy" } ] }, { "name": "SCY1-like protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DMC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6/entry#names_and_taxonomy" } ] }, { "name": "protein-associating with the carboxyl-terminal domain of ezrin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005216949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216949" } ] } ], "function": [ { "annotation": "May play a role in regulating cell adhesion/migration complexes in migrating cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6#function" }, { "database": "UniProtKB", "id": "ARBA00058374", "url": "https://www.uniprot.org/uniprotkb/ARBA00058374#function" }, { "database": "UniProtKB", "id": "F1MVE1", "url": "https://www.uniprot.org/uniprotkb/F1MVE1#function" }, { "database": "UniProtKB", "id": "A0AAA9T4G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCYL3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6", "locus": { "chromosome": "16", "start_pos": 37492622, "end_pos": 37534240, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014794", "url": "https://www.ensembl.org/id/ENSBTAG00000014794" } ] } } ], "crossref": [ { "id": "A0AAF6DMC6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMC6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014794", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014794", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506600", "url": "https://www.ncbi.nlm.nih.gov/gene/506600", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HDPELDW", "url": "https://omabrowser.org/oma/group/HDPELDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MVE1", "url": "https://www.orthodb.org/?gene=F1MVE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12984:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12984:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005216949", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216949", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T4G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVE1", "url": "https://www.uniprot.org/uniprotkb/F1MVE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVE1-1", "url": "https://www.uniprot.org/uniprotkb/F1MVE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSENSALKSYALKEPPFTLPSGLAVYPAVLQDGKLASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVVLETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCVSSVFVSEDGHWKLGGMETVCKVAQATPEFLKSIRSVRDPASIPPEEMSPEFTTLPASHGHARDAYSFGTLVESLLTVLSEQVAADILSSFQHTLRSALLSPSPHCRPALCSLLCHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDNTHGEAPRLLSPALFQARVIPVLLRLFEVHEEHVRVVLLSHLEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTVDLSPEDSPVHVTCSQRSQSLPILKNAPPGIFPKCFSGNMPINSKKHIPQDYYSTFLQTDDQFSQPIKFPINGISEVKITSGDSENFPSSSKKAEEWPDWSEPEEPENKTVNAEVCPADPHAAAQSPLTNLNAEEEPWDDFEPGSLDTEVNLEGGMMPTRPVTSGEQKATPALPSKSSLPPKTSLAQSRDDPDQTKPPKVLSQERRLKVPSELGLGEEFTIQVKKKPVKDPELDWFADMIPEIKPSAAILILPELRTETVVPSKDNVSSVMHFSSKFAAAEITEGESSGWGEDGDLNWDDNSW", "length": 734, "header": "tr|A0AAF6DMC6-1|A0AAF6DMC6_BOVIN Isoform 1 of Protein-associating with the carboxyl-terminal domain of ezrin OS=Bos taurus OX=9913 GN=SCYL3 PE=3 SV=1 CANONICAL=A0AAF6DMC6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G3/entry", "sequence": { "sequence": "MGSENSALKSYALKEPPFTLPSGLAVYPAVLQDGKLASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVVLETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCVSSVFVSEDGHWKLGGMETVCKVAQATPEFLKSIRSVRDPASIPPEEMSPEFTTLPASHGHARDAYSFGTLVESLLTVLSEQVAADILSSFQHTLRSALLSPSPHCRPALCSLLCHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDNTHGEAPRLLSPALFQARVIPVLLRLFEVHEEHVRVVLLSHLEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTVDLSPEDSPVHVTCSQRSQSLPILKNAPPGIFPKCFSGNMPINSKKHIPQDYYSTFLQTDDQFSQPIKFPINGISEVKITSGDSENFPSSSKKAEEWPDWSEPEEPENKTVNAEVCPADPHAAAQSPLTNLNAEEEPWDDFEPGSLDTEVNLEGGMMPTRPVTSGEQKATPALPSKSSLPPKTSLAQSRDDPDQTKPPKVLSQERRLKVPSELGLGEEFTIQVKKKPVKDPELDWFADMIPEIKPSAAILILPELRTETVVPSKDNVSSVMHFSSKFAAAEITEVRIIKLCY", "length": 723, "header": "tr|A0AAA9T4G3-1|A0AAF6DMC6_BOVIN Computationally mapped isoform of Protein-associating with the carboxyl-terminal domain of ezrin OS=Bos taurus OX=9913 GN=SCYL3 PE=3 SV=1 CANONICAL=A0AAF6DMC6-1" }, "locus": { "chromosome": "16", "start_pos": 37529688, "end_pos": 37493759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120976.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120976.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093665.1" } ] } }, { "isoform_ac": "A0AAF6DMC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6/entry", "sequence": { "sequence": "MGSENSALKSYALKEPPFTLPSGLAVYPAVLQDGKLASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVVLETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCVSSVFVSEDGHWKLGGMETVCKVAQATPEFLKSIRSVRDPASIPPEEMSPEFTTLPASHGHARDAYSFGTLVESLLTVLSEQVAADILSSFQHTLRSALLSPSPHCRPALCSLLCHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDNTHGEAPRLLSPALFQARVIPVLLRLFEVHEEHVRVVLLSHLEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTVDLSPEDSPVHVTCSQRSQSLPILKNAPPGIFPKCFSGNMPINSKKHIPQDYYSTFLQTDDQFSQPIKFPINGISEVKITSGDSENFPSSSKKAEEWPDWSEPEEPENKTVNAEVCPADPHAAAQSPLTNLNAEEEPWDDFEPGSLDTEVNLEGGMMPTRPVTSGEQKATPALPSKSSLPPKTSLAQSRDDPDQTKPPKVLSQERRLKVPSELGLGEEFTIQVKKKPVKDPELDWFADMIPEIKPSAAILILPELRTETVVPSKDNVSSVMHFSSKFAAAEITEGESSGWGEDGDLNWDDNSW", "length": 734, "header": "tr|A0AAF6DMC6-1|A0AAF6DMC6_BOVIN Isoform 1 of Protein-associating with the carboxyl-terminal domain of ezrin OS=Bos taurus OX=9913 GN=SCYL3 PE=3 SV=1 CANONICAL=A0AAF6DMC6-1" }, "locus": { "chromosome": "16", "start_pos": 37529688, "end_pos": 37493267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019684.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019684.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019684.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019684.6" } ] } }, { "isoform_ac": "F1MVE1-1", "url": "https://www.uniprot.org/uniprotkb/F1MVE1/entry", "sequence": { "sequence": "MGSENSALKSYALKEPPFTLPSGLAVYPAVLQDGKLASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVVLETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCVSSVFVSEDGHWKLGGMETVCKVAQATPEFLKSIRSVRDPASIPPEEMSPEFTTLPASHGHARDAYSFGTLVESLLTVLSEQVAADILSSFQHTLRSALLSPSPHCRPALCSLLCHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDNTHGEAPRLLSPALFQARVIPVLLRLFEVHEEHVRVVLLSHLEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTVDLSPEDDQFSQPIKFPINGISEVKITSGDSENFPSSSKKAEEWPDWSEPEEPENKTVNAEVCPADPHAAAQSPLTNLNAEEEPWDDFEPGSLDTEVNLEGGMMPTRPVTSGEQKATPALPSKSSLPPKTSLAQSRDDPDQTKPPKVLSQERRLKVPSELGLGEEFTIQVKKKPVKDPELDWFADMIPEIKPSAAILILPELRTETVVPSKDNVSSVMHFSSKFAAAEITEGESSGWGEDGDLNWDDNSW", "length": 681, "header": "tr|F1MVE1-1|F1MVE1_BOVIN Computationally mapped isoform of Protein-associating with the carboxyl-terminal domain of ezrin OS=Bos taurus OX=9913 GN=SCYL3 PE=3 SV=4 CANONICAL=A0AAF6DMC6-1" }, "locus": { "chromosome": "16", "start_pos": 37529688, "end_pos": 37493267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046782.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046782.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044041.5", "url": "https://www.ensembl.org/id/ENSBTAP00000044041.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AE26-1", "protein_name": "Protein-associating with the carboxyl-terminal domain of ezrin", "gene_name": "SCYL3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSENSALKSYTLKDAPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVPQATPEFLRSIQSVRDPASIPPEEMSPEFTTLPESHGHARDAYSFGTLVESLLTILSEQVSADVLSSFQQTLHSTLLNPIPTCRPALCTLLSHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDNARGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHLEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVVITLHSLAVLVSLLGPEVVVGGERSKIFKRTAPSFTKTMDLSPEGDQFSQPMKFPINGISDVKITLGDSDKFPSSSKKSEEWPDWSEPEETENKTVSIEICPTEPYAAARAPLTNLNAEEERWDDFKPSSLDAEINLEGGITAARPVTSGEQKAIPALLPLTQEAKPSKSSLPPKTSLAQSRDDADQTKTTKVWSQERQLKVPSQLGLGEEFTIQVKKKPVKDPELDWFADMIPEIKPSAAILILPEIRTETVVPNKDNVSSVMHFSSKFAAAEISEEESAGWGEEGDLNWEDNNW", "length": 689 }, "evidence": [ { "id": "A0AAF6DMC6", "url": "https://omabrowser.org/oma/group/A0AAF6DMC6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LWB9-1", "protein_name": "Protein-associating with the carboxyl-terminal domain of ezrin", "gene_name": "Scyl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGSENSALKSYTLREPPFTLPSGLAVYPAILQDGKCASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSPAEVCAGIYDVLLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVPQATPEFLRSIQSVRDPASIPPEETSPEFAALPESHGHARDAYSFGTLVDSLLPILKEQVSADVLSSFLQTLHTALLNPTPTCRPALSTLLSHDFFRNDFLEVVNFLRSLTLKSEDEKTEFFKFLLDRVSGLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKENAPGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIDAYVKHFTQDQLKKVILPQVLLGLRDTSNSIVAITLRSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTSDLSPEGSPMHIVCNQQTQISKGLDNPSSNAFPKWLFSGSMPINSKKHIQEEYYNTLLQTGDQFSHSVKFPMNGISDVKNTSEDKGNFPASSSKPEEWPDWSEPEEPEHQTANLQIRPQAPCDGAESQHTNLNAEEESWDDCESGVGTEVNSVAGASAATPVTSEEQKHTAALLPLTQESKPLKPSPSSKTNHMQRGEVKPPEVSQERPLKVRSELGLGEEFTIQVKKKPVQDPELDWFADMVPEIKPSGTFLILPELRTEVMVPNKDNISPVMQFSSKFAAPEMTEGEAEGWEEELTWEDNNW", "length": 735 }, "evidence": [ { "id": "A0AAF6DMC6", "url": "https://omabrowser.org/oma/group/A0AAF6DMC6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YV48-1", "protein_name": "SCY1 like pseudokinase 3", "gene_name": "SCYL3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGSENSALKSYTLEEPPFTLPTGHTIYPAVLQDGRLASVFVYKQENEDMVNKAAKHLKTLRHPCLLRFLSCTVEANGIHLVTERVKPLETVLETLSSAEICAGIYDVLLALTFLHDRGNLTHNNVCLSSVFVSEDGHWKLGGMETVCNFSEATPEFLCHVKSVRDQSCIPCEEMSVDFKILPSSCGHARDAYAFGAMVENLLTALNDQVSADILSSFQQTLHCTLLNPDPKCRPPLSSLLSHEFFRNDFLEVVNFLKTLTLKSEEEKTEFFKFLLDRVAGLSEELIASRLVPLLLNQLVFAEPVAVKSFLPHLLGPKKEQTGESQTNCLLSPALFQTHVIPVLLKLFEVHEEHVRMVLLSHIHAYAELFSREELKNIILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKSSAPSFMKTADFSPEDSPTRTVSNQRHQTSQPLKNNSSVLPISGNAIVKKHSVQQDNPLALNTGEQATQLPLNGVLGSSRSSLTTSEKPAEEWPDWSEPEETENEKTVNIQIQPQKPQGSMGPYFVERDVDEKPWDDFEPSSPHTDLTSGNCLTVTQADAAEMQRTLPGTHQQSKELESLKVSPSTKSSPGNSWNNDKWDHRGQLGKTVLPKQTLEERLKSSLESGLGEEFTIKVKRKPVQDPELDWFADMTPDIKPSSAVLILPEARTEAVVPSHSGAVSSREGASQNALFSSKFAAVDVIEAEAGGWGEEEELNWEDDANW", "length": 746 }, "evidence": [ { "id": "A0AAF6DMC6", "url": "https://omabrowser.org/oma/group/A0AAF6DMC6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZK09-1", "protein_name": "SCY1 like pseudokinase 3", "gene_name": "Scyl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSENSALKSYTLGEPPYTLPSGLAVYPAVLQDGKCASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSPAEVCAGIYDILLALVFLHERGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSVRDPASIPPEEMSPDFAALPESHGHARDAYAFGALVDSLLPIFNEQVSADVLSSFLQTLHSALLSPTPTCRPALSTLLSHDFFRNDFLEVVNFLKSLTLKSEDEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKENAPGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLRSLAVLVSLLGPEVVVGGQRSKIFKRTAPSFTKTSDLSPEGSPMHVVCSQQSRISKVLENPSSNVFPKWFSGNMSINSRKHIQEEYYSTLLQTDVKNTSEDNGSFPAGSNKPEEWPDWSEPEEPEHQTTSIHIWPQEPGDVAETQHTSLSAQELSWDDCESSFGPEVNTAARASAPRPVTSGEQMPTAALLPLTEESKPVQSRPSSKTSHRQQEEVKAPQMSQERPPQVRSELGLGEEFTIQVKKKPAQDPELDWFADMVPEIKPSGTFLILPELRTEGMVPDKDTVSPVMQFSSKFAATEMTEGEAEGWEGEELAWEDDNW", "length": 719 }, "evidence": [ { "id": "A0AAF6DMC6", "url": "https://omabrowser.org/oma/group/A0AAF6DMC6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IZE3-1", "protein_name": "Protein-associating with the carboxyl-terminal domain of ezrin", "gene_name": "SCYL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTTLPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLLSHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLSLEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHIQRDYYNTLLQTGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQKPIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFTIQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAEITEGEAEGWEEEGELNWEDNNW", "length": 742 }, "evidence": [ { "id": "A0AAF6DMC6", "url": "https://omabrowser.org/oma/group/A0AAF6DMC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DBQ7-1", "protein_name": "Protein-associating with the carboxyl-terminal domain of ezrin", "gene_name": "Scyl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSENSALKSYTLRESPFTLPSGLAVYPAILQDGKCASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSPAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCQVPQATPEFLRNIQSVRDPASIPPEEMSPEFSGLPESHGHARDAYAFGALVDSLLPIFNEQVSADVLSSFLQILHSALLNPMPECRPALSTLLSHDFFRNDFLEVVNFLKSLTLKSEDEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKENAPGETPCLLSPALFQSRVIPVLLRLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSNSIVAITLRSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKTSDLSPEGSPMHVVCSQQSRVSKVLEDPSSNVFPKWLSGNVPSSSRKRIQEECYSSLSQTGDQFSHTIKFPMNGLSDVKNTSEDNGSFPAGSNKPEEWPDWSEPEEPEQQPASIHRWPREPCDVAESQHTNLTAEEVTWDDGEASFGTEINSTATASAPVPVTSGGQSTSAALVPLTEESKPLQSSPSSKTSHRQHEEVKPPQVSQERPLKAPSGLGLGEEFTIQVKKKPVQDPELDWFADMIPEIKPSGTFLILPELRTEVMVPDKDNVSSLMQFSSKFAATEMTEGEAEGWEGEELAWEDNNW", "length": 735 }, "evidence": [ { "id": "A0AAF6DMC6", "url": "https://omabrowser.org/oma/group/A0AAF6DMC6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC6" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 286, "start_aa": "Met", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 539, "end_pos": 541 }, { "start_pos": 697, "end_pos": 699 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM75-1", "uniprot_ac": "A0AAF6DM75", "uniprot_id": "A0AAF6DM75_BOVIN", "mass": { "chemical_mass": 38973.0, "monoisotopic_mass": 38973.0 }, "refseq": {}, "gene_names": [ { "name": "MXD4", "type": "recommended", "evidence": [ { "id": "A0AAF6DM75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" } ] } ], "protein_names": [ { "name": "MAX dimerization protein 4", "type": "synonym", "evidence": [ { "id": "A0AAF6DM75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM75", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75", "locus": { "chromosome": "6", "start_pos": 116382861, "end_pos": 116371044, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015209", "url": "https://www.ensembl.org/id/ENSBTAG00000015209" } ] } } ], "crossref": [ { "id": "A0AAF6DM75", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM75", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18929", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18929", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T5P9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM75", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALSGPIGARRLLNMHAGLQSAGAGAGPPRAVAKLGLLNCYYRGGPIGAELRSCQHSRPRLRRAAGSHWPRLDPGPAPAARAPAPICCAGRRSPLCVNLRAARRRGGSRALGESAGVWGSGAAGRAGRAASGAGRAAAAAVPKRSRRGRAGGRMELNSLLILLEAAEYLERRDREAEHGYASVLPFDGDFARKKTKAAGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKMHIKKLEEQDRRALSIKEQLQREHRFLKRRLEQLSAQSLERVRTDSTGSAVSTDDSEQEVDVEGMEFGPGELDSVGSGSDVDDHYSLRGGGCSHGSFGPPCRRPGRPGLS", "length": 362, "header": "tr|A0AAF6DM75-1|A0AAF6DM75_BOVIN Isoform 1 of MAX dimerization protein 4 OS=Bos taurus OX=9913 GN=MXD4 PE=4 SV=1 CANONICAL=A0AAF6DM75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P9/entry", "sequence": { "sequence": "GHSGGTQRVFRARVHLPAAPLGGAQCFSHPRAPRAPHVAVLAQQGIRQSRPGARVVQGTGCKGLTWRGSCTHARSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKMHIKKLEEQDRRALSIKEQLQREHRFLKRRLEQLSAQSLERVRTDSTGSAVSTDDSEQEVDVEGMEFGPGELDSVGSGSDVDDHYSLRGGGCSHGSFGPPCRRPGRPGLS", "length": 228, "header": "tr|A0AAA9T5P9-1|A0AAF6DM75_BOVIN Computationally mapped isoform of MAX dimerization protein 4 OS=Bos taurus OX=9913 GN=MXD4 PE=4 SV=1 CANONICAL=A0AAF6DM75-1" }, "locus": { "chromosome": "6", "start_pos": 116382568, "end_pos": 116373304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112325.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112325.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094096.1" } ] } }, { "isoform_ac": "A0AAF6DM75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75/entry", "sequence": { "sequence": "MALSGPIGARRLLNMHAGLQSAGAGAGPPRAVAKLGLLNCYYRGGPIGAELRSCQHSRPRLRRAAGSHWPRLDPGPAPAARAPAPICCAGRRSPLCVNLRAARRRGGSRALGESAGVWGSGAAGRAGRAASGAGRAAAAAVPKRSRRGRAGGRMELNSLLILLEAAEYLERRDREAEHGYASVLPFDGDFARKKTKAAGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKMHIKKLEEQDRRALSIKEQLQREHRFLKRRLEQLSAQSLERVRTDSTGSAVSTDDSEQEVDVEGMEFGPGELDSVGSGSDVDDHYSLRGGGCSHGSFGPPCRRPGRPGLS", "length": 362, "header": "tr|A0AAF6DM75-1|A0AAF6DM75_BOVIN Isoform 1 of MAX dimerization protein 4 OS=Bos taurus OX=9913 GN=MXD4 PE=4 SV=1 CANONICAL=A0AAF6DM75-1" }, "locus": { "chromosome": "6", "start_pos": 116382568, "end_pos": 116371151, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020233.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020233.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020233.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020233.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM75", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM75", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM75", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM75", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM75" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 206, "end_pos": 258, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YH77-1", "uniprot_ac": "A0AAF6YH77", "uniprot_id": "A0AAF6YH77_BOVIN", "mass": { "chemical_mass": 39577.0, "monoisotopic_mass": 39577.0 }, "refseq": {}, "gene_names": [ { "name": "YKT6", "type": "recommended", "evidence": [ { "id": "A0AAF6YH77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ] } ], "protein_names": [ { "name": "Synaptobrevin homolog YKT6", "type": "recommended", "evidence": [ { "id": "A0AAF6YH77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Essential for the structural and functional organization of the Golgi apparatus.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77#function" }, { "database": "UniProtKB", "id": "ARBA00094485", "url": "https://www.uniprot.org/uniprotkb/ARBA00094485#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YKT6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77", "locus": { "chromosome": "4", "start_pos": 77121694, "end_pos": 77129969, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000274", "url": "https://www.ensembl.org/id/ENSBTAG00000000274" } ] } } ], "crossref": [ { "id": "A0AAF6YH77", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YH77", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14824", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14824", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15867", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15867", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR010908", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010908", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45806", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45806", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45806:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45806:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00957", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00957", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TAH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGALGLTAQRKDSPRDIGVPTVLRRTGKKQGALGGLRTAREGGRRPRRDKDSGRRVRTPSETARWPTKSPQPLTRTRKTLHHPPRSCFRLLFLHPGHEKTPLGLGRQPLTGTGSGPRARRRKPVADPSAAGGGLEGRRCAAPCEPVPRPGGWPAQGPGAMKLYSLSVLYKGESKTVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSAKGSRASVKEQEYLCHVYVRNDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWPTGSPDTIRYSGLDSQLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGIQSKAFYKTARKQNSCCAIM", "length": 358, "header": "tr|A0AAF6YH77-1|A0AAF6YH77_BOVIN Isoform 1 of Synaptobrevin homolog YKT6 OS=Bos taurus OX=9913 GN=YKT6 PE=3 SV=1 CANONICAL=A0AAF6YH77-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH0/entry", "sequence": { "sequence": "MKLYSLSVLYKGESKTVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSAKGSRASVKEQEYLCHVYVRNDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWPTGSPDTIRYSGLDSQLSRYQNPREADPMTKVQAELDETKIILARKQNSCCAIM", "length": 164, "header": "tr|A0AAA9TAH0-1|A0AAF6YH77_BOVIN Computationally mapped isoform of Synaptobrevin homolog YKT6 OS=Bos taurus OX=9913 GN=YKT6 PE=3 SV=1 CANONICAL=A0AAF6YH77-1" }, "locus": { "chromosome": "4", "start_pos": 77129375, "end_pos": 77121963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107079.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107079.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093000.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093000.1" } ] } }, { "isoform_ac": "A0AAF6YH77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77/entry", "sequence": { "sequence": "MGGALGLTAQRKDSPRDIGVPTVLRRTGKKQGALGGLRTAREGGRRPRRDKDSGRRVRTPSETARWPTKSPQPLTRTRKTLHHPPRSCFRLLFLHPGHEKTPLGLGRQPLTGTGSGPRARRRKPVADPSAAGGGLEGRRCAAPCEPVPRPGGWPAQGPGAMKLYSLSVLYKGESKTVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSAKGSRASVKEQEYLCHVYVRNDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWPTGSPDTIRYSGLDSQLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGIQSKAFYKTARKQNSCCAIM", "length": 358, "header": "tr|A0AAF6YH77-1|A0AAF6YH77_BOVIN Isoform 1 of Synaptobrevin homolog YKT6 OS=Bos taurus OX=9913 GN=YKT6 PE=3 SV=1 CANONICAL=A0AAF6YH77-1" }, "locus": { "chromosome": "4", "start_pos": 77129855, "end_pos": 77121963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000341.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000341.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000341.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000341.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YH77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" }, { "id": "PS50859", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50859" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Longin", "eco_id": "ECO_0000259", "start_pos": 168, "end_pos": 291, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YH77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH77" }, { "id": "PS50892", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50892" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "V-SNARE coiled-coil homology", "eco_id": "ECO_0000259", "start_pos": 298, "end_pos": 358, "start_aa": "Pro", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 232, "end_pos": 234 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLX2-1", "uniprot_ac": "A0AAF6DLX2", "uniprot_id": "A0AAF6DLX2_BOVIN", "mass": { "chemical_mass": 70299.0, "monoisotopic_mass": 70299.0 }, "refseq": { "ac": "XP_010803496", "name": "netrin-4 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803496" }, "gene_names": [ { "name": "NTN4", "type": "recommended", "evidence": [ { "id": "A0AAF6DLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" } ] }, { "name": "NTN4", "type": "synonym", "evidence": [ { "id": "XP_010803496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803496" } ] } ], "protein_names": [ { "name": "Netrin-4", "type": "recommended", "evidence": [ { "id": "A0AAF6DLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2/entry#names_and_taxonomy" } ] }, { "name": "netrin-4 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010803496", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803496" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NTN4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2", "locus": { "chromosome": "5", "start_pos": 60031676, "end_pos": 60161682, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003183", "url": "https://www.ensembl.org/id/ENSBTAG00000003183" } ] } } ], "crossref": [ { "id": "A0AAF6DLX2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLX2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537455", "url": "https://www.ncbi.nlm.nih.gov/gene/537455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574:SF282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010803496", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803496", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSCARLLLLWGCSAVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWTDTTCGQNATELYCFYSENTDLTCQQPKCDKCNAAQPHLAHLPAAMADSSFRYPRTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPNDMENPYGAKVQEQLKITNLRVQLLKRQSCPCQRNHLNAEPQHFTHYAIYDFIVKGSCFCNGHADQCIPIDGFRPVKAPGAFHVVHGKCICKHNTAGTHCQHCAPLYNDRPWEAADGKTGSPNECRTCKCNGHADACHFDINVWEASGNRSGGVCNDCQHNTEGQHCQRCKPGFYWDLRRPFSAPDACKSCSCHPVGSAVLPFSSVTFCDPSNGDCPCKPGVAGPHCERCMVGYWGFGDYGCRPCDCAGSCDPHTGDCLSSSTDIDWYHEVPDFHSMHNKSEPTWDWKDEQGFSALRHSGGTRGKCECKEQVLGNSKAFCGMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLKSTKLKILRGKRTLYPESWTNRGCTCPILNPGLEYLVAGHEDVRTGKLVVNMKSFVQHWKPSLGRKVMDILRRECK", "length": 632, "header": "tr|A0AAF6DLX2-1|A0AAF6DLX2_BOVIN Isoform 1 of Netrin-4 OS=Bos taurus OX=9913 GN=NTN4 PE=4 SV=1 CANONICAL=A0AAF6DLX2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW7/entry", "sequence": { "sequence": "MGSCARLLLLWGCSAVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWTDTTCGQNATELYCFYSENTDLTCQQPKCDKCNAAQPHLAHLPAAMADSSFRYPRTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPNDMENPYGAKVQEQLKITNLRVQLLKRQSCPCQRNHLNAEPQHFTHYAIYDFIVKGSCFCNGHADQCIPIDGFRPVKAPGAFHVVHGKCICKHNTAGTHCQHCAPLYNDRPWEAADGKTGSPNECRTCKCNGHADACHFDINVWEASGNRSGGVCNDCQHNTEGQHCQRCKPGFYWDLRRPFSAPDACKSCSCHPVGSAVLPFSSVTFCDPSNGDCPCKPGVAGPHCERCMVGYWGFGDYGCRPCDCAGSCDPHTGDCLSSSTDIDWYHEVPDFHSMHNKSEPTWDWKDEQGFSALRHSVLKIKILSAHDKGSHAEVNVKIKKVLKSTKLKILRGKRTLYPESWTNRGCTCPILNPGLEYLVAGHEDVRTGKLVVNMKSFVQHWKPSLGRKVMDILRRECK", "length": 605, "header": "tr|A0AAA9TAW7-1|A0AAF6DLX2_BOVIN Computationally mapped isoform of Netrin-4 OS=Bos taurus OX=9913 GN=NTN4 PE=4 SV=1 CANONICAL=A0AAF6DLX2-1" }, "locus": { "chromosome": "5", "start_pos": 60161283, "end_pos": 60032981, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101351.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101351.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093797.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093797.1" } ] } }, { "isoform_ac": "A0AAF6DLX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2/entry", "sequence": { "sequence": "MGSCARLLLLWGCSAVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWTDTTCGQNATELYCFYSENTDLTCQQPKCDKCNAAQPHLAHLPAAMADSSFRYPRTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPNDMENPYGAKVQEQLKITNLRVQLLKRQSCPCQRNHLNAEPQHFTHYAIYDFIVKGSCFCNGHADQCIPIDGFRPVKAPGAFHVVHGKCICKHNTAGTHCQHCAPLYNDRPWEAADGKTGSPNECRTCKCNGHADACHFDINVWEASGNRSGGVCNDCQHNTEGQHCQRCKPGFYWDLRRPFSAPDACKSCSCHPVGSAVLPFSSVTFCDPSNGDCPCKPGVAGPHCERCMVGYWGFGDYGCRPCDCAGSCDPHTGDCLSSSTDIDWYHEVPDFHSMHNKSEPTWDWKDEQGFSALRHSGGTRGKCECKEQVLGNSKAFCGMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLKSTKLKILRGKRTLYPESWTNRGCTCPILNPGLEYLVAGHEDVRTGKLVVNMKSFVQHWKPSLGRKVMDILRRECK", "length": 632, "header": "tr|A0AAF6DLX2-1|A0AAF6DLX2_BOVIN Isoform 1 of Netrin-4 OS=Bos taurus OX=9913 GN=NTN4 PE=4 SV=1 CANONICAL=A0AAF6DLX2-1" }, "locus": { "chromosome": "5", "start_pos": 60161283, "end_pos": 60032981, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004136.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004136.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004136.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004136.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "laminin-1 binding", "id": "GO:0043237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043237", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" }, { "id": "PS50027", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50027" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin EGF-like", "eco_id": "ECO_0000259", "start_pos": 332, "end_pos": 394, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" }, { "id": "PS51117", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin N-terminal", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 261, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX2" }, { "id": "PS50189", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50189" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTR", "eco_id": "ECO_0000259", "start_pos": 510, "end_pos": 631, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 483, "end_pos": 485 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YKP0-1", "uniprot_ac": "A0AAF6YKP0", "uniprot_id": "A0AAF6YKP0_BOVIN", "mass": { "chemical_mass": 29290.0, "monoisotopic_mass": 29290.0 }, "refseq": {}, "gene_names": [ { "name": "PSMB8", "type": "recommended", "evidence": [ { "id": "A0AAF6YKP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ] } ], "protein_names": [ { "name": "Proteasome subunit beta", "type": "recommended", "evidence": [ { "id": "A0AAF6YKP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0#function" }, { "database": "UniProtKB", "id": "RU004203", "url": "https://www.uniprot.org/uniprotkb/RU004203#function" } ] }, { "annotation": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein. Required for adipocyte differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0#function" }, { "database": "UniProtKB", "id": "ARBA00056462", "url": "https://www.uniprot.org/uniprotkb/ARBA00056462#function" }, { "database": "UniProtKB", "id": "A0AAA9TCG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCG8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMB8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0", "locus": { "chromosome": "23", "start_pos": 7173038, "end_pos": 7176683, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003039", "url": "https://www.ensembl.org/id/ENSBTAG00000003039" } ] } } ], "crossref": [ { "id": "A0AAF6YKP0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YKP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000243", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR32194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32194:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32194:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TCG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLDVCGAPGGQRGDWAVPLAGSRQRSDPGHYGFSLRSPELALPRGMQPTEFFRSLGGNGESKVQIEMAHGTTTLAFKFQHGVIVAVDSRASAGNYIATLKVNKVIEINPYLLGTMSGCAADCLYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDENGTRLSGNMFSTGSGNSHAYGVMDSGYRPDLSIEEAYDLGRRAIVHATHRDSYSGGVVNMSAGPRRGDHDSMLFPVCLQCTT", "length": 270, "header": "tr|A0AAF6YKP0-1|A0AAF6YKP0_BOVIN Isoform 1 of Proteasome subunit beta OS=Bos taurus OX=9913 GN=PSMB8 PE=3 SV=1 CANONICAL=A0AAF6YKP0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCG8/entry", "sequence": { "sequence": "MWKTFWFPPLKASGFRFHFLLREPPDLWVLGGHGAARRVRSPRRAAGGLGCAPRGKPAALGPRPLRLLPAISGARPPPGHAATLKVNKVIEINPYLLGTMSGCAADCLYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDENGTRLSGNMFSTGSGNSHAYGVMDSGYRPDLSIEEAYDLGRRAIVHATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLMHQYREASQ", "length": 259, "header": "tr|A0AAA9TCG8-1|A0AAF6YKP0_BOVIN Computationally mapped isoform of Proteasome subunit beta OS=Bos taurus OX=9913 GN=PSMB8 PE=3 SV=1 CANONICAL=A0AAF6YKP0-1" }, "locus": { "chromosome": "23", "start_pos": 7176484, "end_pos": 7173268, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126572.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126572.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094434.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094434.1" } ] } }, { "isoform_ac": "A0AAF6YKP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0/entry", "sequence": { "sequence": "MALLDVCGAPGGQRGDWAVPLAGSRQRSDPGHYGFSLRSPELALPRGMQPTEFFRSLGGNGESKVQIEMAHGTTTLAFKFQHGVIVAVDSRASAGNYIATLKVNKVIEINPYLLGTMSGCAADCLYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDENGTRLSGNMFSTGSGNSHAYGVMDSGYRPDLSIEEAYDLGRRAIVHATHRDSYSGGVVNMSAGPRRGDHDSMLFPVCLQCTT", "length": 270, "header": "tr|A0AAF6YKP0-1|A0AAF6YKP0_BOVIN Isoform 1 of Proteasome subunit beta OS=Bos taurus OX=9913 GN=PSMB8 PE=3 SV=1 CANONICAL=A0AAF6YKP0-1" }, "locus": { "chromosome": "23", "start_pos": 7176387, "end_pos": 7173345, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003955.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003955.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003955.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003955.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" }, { "name": "proteasome core complex", "id": "GO:0005839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" }, { "name": "spermatoproteasome complex", "id": "GO:1990111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990111", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" }, { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "threonine-type endopeptidase activity", "id": "GO:0004298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004298", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.25.1", "ec_name": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "3.4.25.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.25.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 247, "end_pos": 249 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVZ7-1", "uniprot_ac": "A0AAF6YVZ7", "uniprot_id": "A0AAF6YVZ7_BOVIN", "mass": { "chemical_mass": 41125.0, "monoisotopic_mass": 41125.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM129", "type": "recommended", "evidence": [ { "id": "A0AAF6YVZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ] } ], "protein_names": [ { "name": "Transmembrane protein 129, E3 ubiquitin ligase", "type": "synonym", "evidence": [ { "id": "A0AAF6YVZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM129", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7", "locus": { "chromosome": "6", "start_pos": 116840066, "end_pos": 116835679, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011042", "url": "https://www.ensembl.org/id/ENSBTAG00000011042" } ] } } ], "crossref": [ { "id": "A0AAF6YVZ7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVZ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31322", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31322", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31322:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31322:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10272", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10272", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSPEVTFTLAYLVFAVCFVFTPTEFHSAGLTVQNLLSGWLGSEDAAFVPYHLRRTAATLLCHSLLPLGYYVGMCFAASEKQLYYPSQTPETWRAFLLLALMLPAIACTLIYYWSRDHWACHPLARTLALYALPRSGWQAVASSVNTEFRRIDKFATGVPGARVIVTDTWVMKVTTYRVHVAQQQDVRLTVTEAQQHELSPDSHLPVQLLTIRVASANPAVPAFHIRTHLYRLNSTEYGELCEKLRAPIRSAANVVIHQSLGDLFLETFASLVEVNPAYSVPSSQDLEACIGCMQTQASVKLVKTCQEVAVGECQQCYCRPMWCLTCMGKWFASRQDPQRPDTWLASRVPCPTCRARFCVLDVCAVR", "length": 367, "header": "tr|A0AAF6YVZ7-1|A0AAF6YVZ7_BOVIN Isoform 1 of Transmembrane protein 129, E3 ubiquitin ligase OS=Bos taurus OX=9913 GN=TMEM129 PE=3 SV=1 CANONICAL=A0AAF6YVZ7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW2/entry", "sequence": { "sequence": "MDSPEVTFTLAYLVFAVCFVFTPTEFHSAGLTVQNLLSGWLGSEDAAFVPYHLRRTAATLLCHSLLPLGYYVGMCFAASEKQLYYPSQTPETWRAFLLLALMLPAIACTLIYYWSRDHWACHPLARTLALYALPRSGWQAVASSVNTEFRRIDKFATGVPGARVIVTDTWVMKVTTYRVHVAQQQDVRLTVTEAQQHELSPDSHLPVQLLTIRVASANPAVPAFHIRTWRHAS", "length": 233, "header": "tr|A0AAA9TCW2-1|A0AAF6YVZ7_BOVIN Computationally mapped isoform of Transmembrane protein 129, E3 ubiquitin ligase OS=Bos taurus OX=9913 GN=TMEM129 PE=3 SV=1 CANONICAL=A0AAF6YVZ7-1" }, "locus": { "chromosome": "6", "start_pos": 116838561, "end_pos": 116835750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131675.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131675.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093974.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093974.1" } ] } }, { "isoform_ac": "A0AAF6YVZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7/entry", "sequence": { "sequence": "MDSPEVTFTLAYLVFAVCFVFTPTEFHSAGLTVQNLLSGWLGSEDAAFVPYHLRRTAATLLCHSLLPLGYYVGMCFAASEKQLYYPSQTPETWRAFLLLALMLPAIACTLIYYWSRDHWACHPLARTLALYALPRSGWQAVASSVNTEFRRIDKFATGVPGARVIVTDTWVMKVTTYRVHVAQQQDVRLTVTEAQQHELSPDSHLPVQLLTIRVASANPAVPAFHIRTHLYRLNSTEYGELCEKLRAPIRSAANVVIHQSLGDLFLETFASLVEVNPAYSVPSSQDLEACIGCMQTQASVKLVKTCQEVAVGECQQCYCRPMWCLTCMGKWFASRQDPQRPDTWLASRVPCPTCRARFCVLDVCAVR", "length": 367, "header": "tr|A0AAF6YVZ7-1|A0AAF6YVZ7_BOVIN Isoform 1 of Transmembrane protein 129, E3 ubiquitin ligase OS=Bos taurus OX=9913 GN=TMEM129 PE=3 SV=1 CANONICAL=A0AAF6YVZ7-1" }, "locus": { "chromosome": "6", "start_pos": 116838788, "end_pos": 116835750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014663.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014663.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014663.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014663.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" }, { "name": "retrograde protein transport, ER to cytosol", "id": "GO:0030970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030970", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YMF2-1", "uniprot_ac": "A0AAF6YMF2", "uniprot_id": "A0AAF6YMF2_BOVIN", "mass": { "chemical_mass": 23949.0, "monoisotopic_mass": 23949.0 }, "refseq": { "ac": "XP_024856589", "name": "PRELI domain containing protein 3B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856589" }, "gene_names": [ { "name": "PRELID3B", "type": "recommended", "evidence": [ { "id": "A0AAF6YMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2" } ] }, { "name": "C20ORF45", "type": "synonym", "evidence": [ { "id": "XP_024856589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856589" } ] }, { "name": "PRELID3B", "type": "synonym", "evidence": [ { "id": "XP_024856589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856589" } ] }, { "name": "SLMO2", "type": "synonym", "evidence": [ { "id": "XP_024856589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856589" } ] } ], "protein_names": [ { "name": "PRELI domain containing 3B", "type": "synonym", "evidence": [ { "id": "A0AAF6YMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2/entry#names_and_taxonomy" } ] }, { "name": "PRELI domain containing protein 3B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856589" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRELID3B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2", "locus": { "chromosome": "13", "start_pos": 57356298, "end_pos": 57347406, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004402", "url": "https://www.ensembl.org/id/ENSBTAG00000004402" } ] } } ], "crossref": [ { "id": "A0AAF6YMF2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YMF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "616523", "url": "https://www.ncbi.nlm.nih.gov/gene/616523", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856589", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856589", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIWTSEHVFDPVGPRILEKGVDCRDSGRSATFSHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTILTQEAIITVKGVSLGSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELTASARGSIRTPMAAAAFVEK", "length": 217, "header": "tr|A0AAF6YMF2-1|A0AAF6YMF2_BOVIN Isoform 1 of PRELI domain containing 3B OS=Bos taurus OX=9913 GN=PRELID3B PE=4 SV=1 CANONICAL=A0AAF6YMF2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ4/entry", "sequence": { "sequence": "MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTILTQEAIITVKGVSLGSYLEGLMASTISSNANKSARLDWGDSGEQNKRGACPRGTKRKATLIIQHGIRKGKVQKGPRSNGVGNT", "length": 206, "header": "tr|A0AAA9TDQ4-1|A0AAF6YMF2_BOVIN Computationally mapped isoform of PRELI domain containing 3B OS=Bos taurus OX=9913 GN=PRELID3B PE=4 SV=1 CANONICAL=A0AAF6YMF2-1" }, "locus": { "chromosome": "13", "start_pos": 57355294, "end_pos": 57347513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088283.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088283.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096750.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096750.1" } ] } }, { "isoform_ac": "A0AAA9TUQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUQ5/entry", "sequence": { "sequence": "MKSSSSHHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTILTQEAIITVKGVSLGSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELTASARGSIRTPMAAAAFVEK", "length": 190, "header": "tr|A0AAA9TUQ5-1|A0AAF6YMF2_BOVIN Computationally mapped isoform of PRELI domain containing 3B OS=Bos taurus OX=9913 GN=PRELID3B PE=4 SV=2 CANONICAL=A0AAF6YMF2-1" }, "locus": { "chromosome": "13", "start_pos": 57355382, "end_pos": 57351413, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097815.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097815.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101079.1" } ] } }, { "isoform_ac": "A0AAF6YMF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2/entry", "sequence": { "sequence": "MKIWTSEHVFDPVGPRILEKGVDCRDSGRSATFSHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHIDPSGKLHSHRLLSTEWGLPSIVKSIIGAARTKTYVQEHSVVDPVEKTMELKSTNISFTNMVSVDERLIYKPHPQDPEKTILTQEAIITVKGVSLGSYLEGLMASTISSNANKGREAMEWVIHKLNAEIEELTASARGSIRTPMAAAAFVEK", "length": 217, "header": "tr|A0AAF6YMF2-1|A0AAF6YMF2_BOVIN Isoform 1 of PRELI domain containing 3B OS=Bos taurus OX=9913 GN=PRELID3B PE=4 SV=1 CANONICAL=A0AAF6YMF2-1" }, "locus": { "chromosome": "13", "start_pos": 57355382, "end_pos": 57347513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005773.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005773.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005773.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005773.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMF2" }, { "id": "PS50904", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50904" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PRELI/MSF1", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 195, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YGN5-1", "uniprot_ac": "A0AAF6YGN5", "uniprot_id": "A0AAF6YGN5_BOVIN", "mass": { "chemical_mass": 14738.0, "monoisotopic_mass": 14738.0 }, "refseq": {}, "gene_names": [ { "name": "TUSC2", "type": "recommended", "evidence": [ { "id": "A0AAF6YGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5" } ] } ], "protein_names": [ { "name": "Tumor suppressor 2, mitochondrial calcium regulator", "type": "synonym", "evidence": [ { "id": "A0AAF6YGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUSC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5", "locus": { "chromosome": "22", "start_pos": 50022052, "end_pos": 50016675, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058889", "url": "https://www.ensembl.org/id/ENSBTAG00000058889" } ] } } ], "crossref": [ { "id": "A0AAF6YGN5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YGN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15453:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15453:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15000", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15000", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TE00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGASGSKARGLWPFTSAAGGGGPEAAVAEQALVRPRGRVVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGTVKLDPPRIHVDFPVILYEARAQGMGWPSRPGPFGELRTPGKRI", "length": 134, "header": "tr|A0AAF6YGN5-1|A0AAF6YGN5_BOVIN Isoform 1 of Tumor suppressor 2, mitochondrial calcium regulator OS=Bos taurus OX=9913 GN=TUSC2 PE=4 SV=1 CANONICAL=A0AAF6YGN5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TE00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE00/entry", "sequence": { "sequence": "MGASGSKARGLWPFTSAAGGGGPEAAVAEQALVRPRGRVVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGTVKLDPPRIHVDFPVILYETLHTRLTSSEAVTPSVWTTTWA", "length": 131, "header": "tr|A0AAA9TE00-1|A0AAF6YGN5_BOVIN Computationally mapped isoform of Tumor suppressor 2, mitochondrial calcium regulator OS=Bos taurus OX=9913 GN=TUSC2 PE=4 SV=1 CANONICAL=A0AAF6YGN5-1" }, "locus": { "chromosome": "22", "start_pos": 50019690, "end_pos": 50016891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100592.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100592.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094399.1" } ] } }, { "isoform_ac": "A0AAF6YGN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5/entry", "sequence": { "sequence": "MGASGSKARGLWPFTSAAGGGGPEAAVAEQALVRPRGRVVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGTVKLDPPRIHVDFPVILYEARAQGMGWPSRPGPFGELRTPGKRI", "length": 134, "header": "tr|A0AAF6YGN5-1|A0AAF6YGN5_BOVIN Isoform 1 of Tumor suppressor 2, mitochondrial calcium regulator OS=Bos taurus OX=9913 GN=TUSC2 PE=4 SV=1 CANONICAL=A0AAF6YGN5-1" }, "locus": { "chromosome": "22", "start_pos": 50021947, "end_pos": 50016891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000612.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000612.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000612.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000612.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJR2-1", "uniprot_ac": "A0AAF6YJR2", "uniprot_id": "A0AAF6YJR2_BOVIN", "mass": { "chemical_mass": 33606.0, "monoisotopic_mass": 33606.0 }, "refseq": {}, "gene_names": [ { "name": "FKBP3", "type": "recommended", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] } ], "protein_names": [ { "name": "peptidylprolyl isomerase", "type": "recommended", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2/entry#names_and_taxonomy" } ] }, { "name": "5.2.1.8", "type": "synonym", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2#function" }, { "database": "UniProtKB", "id": "ARBA00053175", "url": "https://www.uniprot.org/uniprotkb/ARBA00053175#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FKBP3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2", "locus": { "chromosome": "21", "start_pos": 54845025, "end_pos": 54855471, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002610", "url": "https://www.ensembl.org/id/ENSBTAG00000002610" } ] } } ], "crossref": [ { "id": "A0AAF6YJR2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJR2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46493:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46493:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00254", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00254", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16237", "url": "https://www.rhea-db.org/rhea/16237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TGG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSFSAESVFAATSAGFTRDSTKRPAEHSLDVAQTLAPILRGIAVTPPPRAPSGTRATPMGRGDAEARRAGSVKRRQRGKMAAAVPQRAWTVEQLRSEQLPKKDIIKFLQDHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFESKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSSKKKKNAKPLSFKVGIGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLIFEVELVDID", "length": 304, "header": "tr|A0AAF6YJR2-1|A0AAF6YJR2_BOVIN Isoform 1 of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP3 PE=3 SV=1 CANONICAL=A0AAF6YJR2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TGG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG5/entry", "sequence": { "sequence": "MGARGLEAWLRSLEGSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFESKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSSKKKKNAKPLSFKVGIGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLIFEVELVDID", "length": 204, "header": "tr|A0AAA9TGG5-1|A0AAF6YJR2_BOVIN Computationally mapped isoform of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP3 PE=3 SV=1 CANONICAL=A0AAF6YJR2-1" }, "locus": { "chromosome": "21", "start_pos": 54854804, "end_pos": 54845306, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087801.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087801.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096137.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096137.1" } ] } }, { "isoform_ac": "A0AAA9TLV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV2/entry", "sequence": { "sequence": "MAAAVPQRAWTVEQLRSEQLPKKDIIKFLQDHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFESKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSSKKKKNAKPLSFKVGIGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKYPFFLVNLYCQVLTSIQK", "length": 225, "header": "tr|A0AAA9TLV2-1|A0AAF6YJR2_BOVIN Computationally mapped isoform of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP3 PE=3 SV=1 CANONICAL=A0AAF6YJR2-1" }, "locus": { "chromosome": "21", "start_pos": 54855224, "end_pos": 54845667, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097278.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097278.1" } ] } }, { "isoform_ac": "A0AAF6YJR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2/entry", "sequence": { "sequence": "MLSFSAESVFAATSAGFTRDSTKRPAEHSLDVAQTLAPILRGIAVTPPPRAPSGTRATPMGRGDAEARRAGSVKRRQRGKMAAAVPQRAWTVEQLRSEQLPKKDIIKFLQDHGSDSFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFESKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSSKKKKNAKPLSFKVGIGKVIRGWDEALLTMSKGEKARLEIEPEWAYGKKGQPDAKIPPNAKLIFEVELVDID", "length": 304, "header": "tr|A0AAF6YJR2-1|A0AAF6YJR2_BOVIN Isoform 1 of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP3 PE=3 SV=1 CANONICAL=A0AAF6YJR2-1" }, "locus": { "chromosome": "21", "start_pos": 54855464, "end_pos": 54845306, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003377.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003377.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003377.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003377.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 46, "start_aa": "Thr", "end_pos": 46, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr46", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4A4-1", "P18203-1", "Q5BIN5-1", "A6QPY8-1", "F1N4S5-1", "F1N6W2-1", "G3X8B1-1", "A0A3Q1LI03-1", "A0AAA9TG77-1", "F1MNW5-1", "E1B9G4-1", "G3MXV0-1", "Q2KJC8-1", "A0AAF6YJC8-1", "A0AAF6YJR2-1", "P26882-1", "F6RD06-1", "Q32PA9-1", "Q0P5D0-1", "Q2KJ44-1", "Q2HJ89-1", "Q08E11-1", "Q9TRY0-1", "A0A3Q1LK42-1", "A4FV72-1", "P26884-1", "P30404-1", "P62935-1", "P68107-1", "Q29RZ2-1", "P80311-1", "A0AAA9RV00-1", "F1MU79-1", "A0A3Q1LJJ1-1", "Q5E992-1", "Q2YDL5-1", "A0AAA9U018-1", "A0ABI0NKM5-1", "A0ABI0NMT7-1", "A0A3Q1LSB7-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LI03", "gene_name": "FKBP11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI03" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI03" } ] } ] }, { "uniprot_ac": "A0A3Q1LJJ1", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ1" } ] } ] }, { "uniprot_ac": "A0A3Q1LK42", "gene_name": "FKBP8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] } ] }, { "uniprot_ac": "A0A3Q1LSB7", "gene_name": "LOC786614", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSB7" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSB7" } ] } ] }, { "uniprot_ac": "A0A3Q1M4A4", "gene_name": "LOC112445968", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1M4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4A4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1M4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4A4" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9TG77", "gene_name": "FKBP15", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9TG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG77" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9TG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG77" } ] } ] }, { "uniprot_ac": "A0AAA9U018", "gene_name": "AIP", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9U018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U018" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9U018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U018" } ] } ] }, { "uniprot_ac": "A0AAF6YJC8", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAF6YJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAF6YJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC8" } ] } ] }, { "uniprot_ac": "A0AAF6YJR2", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] } ] }, { "uniprot_ac": "A0ABI0NKM5", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0ABI0NKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKM5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0ABI0NKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKM5" } ] } ] }, { "uniprot_ac": "A0ABI0NMT7", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0ABI0NMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT7" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0ABI0NMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT7" } ] } ] }, { "uniprot_ac": "A4FV72", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A4FV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV72" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A4FV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV72" } ] } ] }, { "uniprot_ac": "A6QPY8", "gene_name": "PIN4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A6QPY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPY8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A6QPY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPY8" } ] } ] }, { "uniprot_ac": "E1B9G4", "gene_name": "PPIL3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] } ] }, { "uniprot_ac": "F1MNW5", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1MNW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1MNW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW5" } ] } ] }, { "uniprot_ac": "F1MU79", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1MU79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU79" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1MU79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU79" } ] } ] }, { "uniprot_ac": "F1N4S5", "gene_name": "FKBP14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] } ] }, { "uniprot_ac": "F1N6W2", "gene_name": "PPIL4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] } ] }, { "uniprot_ac": "F6RD06", "gene_name": "FKBP7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F6RD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD06" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F6RD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD06" } ] } ] }, { "uniprot_ac": "G3MXV0", "gene_name": "FKBP5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3MXV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXV0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3MXV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXV0" } ] } ] }, { "uniprot_ac": "G3X8B1", "gene_name": "LOC613401", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3X8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X8B1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3X8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X8B1" } ] } ] }, { "uniprot_ac": "P18203", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P18203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18203" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P18203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18203" } ] } ] }, { "uniprot_ac": "P26882", "gene_name": "PPID", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26882" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26882" } ] } ] }, { "uniprot_ac": "P26884", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26884" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26884" } ] } ] }, { "uniprot_ac": "P30404", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30404" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30404" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68107", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68107" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P68107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68107" } ] } ] }, { "uniprot_ac": "P80311", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] } ] }, { "uniprot_ac": "Q08E11", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q08E11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E11" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q08E11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E11" } ] } ] }, { "uniprot_ac": "Q0P5D0", "gene_name": "PPIH", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q0P5D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5D0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q0P5D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5D0" } ] } ] }, { "uniprot_ac": "Q29RZ2", "gene_name": "PPWD1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q29RZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q29RZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ2" } ] } ] }, { "uniprot_ac": "Q2HJ89", "gene_name": "FKBP10", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2HJ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ89" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2HJ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ89" } ] } ] }, { "uniprot_ac": "Q2KJ44", "gene_name": "PTPA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2KJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ44" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2KJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ44" } ] } ] }, { "uniprot_ac": "Q2KJC8", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2KJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJC8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2KJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJC8" } ] } ] }, { "uniprot_ac": "Q2YDL5", "gene_name": "FKBP11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] } ] }, { "uniprot_ac": "Q32PA9", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q32PA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q32PA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA9" } ] } ] }, { "uniprot_ac": "Q5BIN5", "gene_name": "PIN1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] } ] }, { "uniprot_ac": "Q5E992", "gene_name": "PPIL1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5E992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5E992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ] } ] }, { "uniprot_ac": "Q9TRY0", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q9TRY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TRY0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q9TRY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TRY0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" }, { "id": "PS50059", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50059" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPIase FKBP-type", "eco_id": "ECO_0000259", "start_pos": 208, "end_pos": 304, "start_aa": "Gly", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.2.1.8", "ec_name": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "5.2.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8" }, { "id": "5.2.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.2.1.8" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 46 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMG9-1", "uniprot_ac": "A0AAF6DMG9", "uniprot_id": "A0AAF6DMG9_BOVIN", "mass": { "chemical_mass": 54222.0, "monoisotopic_mass": 54222.0 }, "refseq": {}, "gene_names": [ { "name": "EIF2B3", "type": "recommended", "evidence": [ { "id": "A0AAF6DMG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ] } ], "protein_names": [ { "name": "Translation initiation factor eIF2B subunit gamma", "type": "recommended", "evidence": [ { "id": "A0AAF6DMG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9/entry#names_and_taxonomy" } ] }, { "name": "eIF2B GDP-GTP exchange factor subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAF6DMG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9#function" }, { "database": "UniProtKB", "id": "ARBA00045373", "url": "https://www.uniprot.org/uniprotkb/ARBA00045373#function" }, { "database": "UniProtKB", "id": "A0AAA9THE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE2#function" }, { "database": "UniProtKB", "id": "A0AAA9TUN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN0#function" }, { "database": "UniProtKB", "id": "A0AAA9U1I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF2B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9", "locus": { "chromosome": "3", "start_pos": 101173086, "end_pos": 101059196, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019010", "url": "https://www.ensembl.org/id/ENSBTAG00000019010" } ] } } ], "crossref": [ { "id": "A0AAF6DMG9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04198", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04198", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04652", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04652", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45989", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45989", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45989:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45989:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9THE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEELVSTVIQDNPGRISEHNMRTTTCLIVFTENLYVPEVIVITTKDVQKALCADFNKMKMKLDIVCIPDEADMGTADSLRHIYQKLKTDVLVLSCDLITDVALHEVVDLFRAHDASLAMLMRKGQESLEPVPGQKGKKKAVEQRDFVGVDSTGKRLLFMANEADLDEELIIKGSILQKHPRIRFHTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLTLAPYDTCWNTCRGDSWEGLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVSKLLPVICPEESLIHSSAQIVSKHMVGADSLIGPDTQVGEKSSIKHSVIGSSCVIRDRVTVTNCLLMNSVTVEEGSNIQSSIICNDAVIEKGADIKNCLIGSGQRIEAKAKRVNVIVGNDQFLEI", "length": 487, "header": "tr|A0AAF6DMG9-1|A0AAF6DMG9_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit gamma OS=Bos taurus OX=9913 GN=EIF2B3 PE=3 SV=1 CANONICAL=A0AAF6DMG9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE2/entry", "sequence": { "sequence": "MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVITTKDVQKALCADFNKMKMKLDIVCIPDEADMGTADSLRHIYQKLKTDVLVLSCDLITDVALHEVVDLFRAHDASLAMLMRKGQESLEPVPGQKGKKKAVEQRDFVGVDSTGKRLLFMANEADLDEELIIKGSILQKHPRIRFHTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLTLAPYDTCWNTCRGDSWEGLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVSKLLPVICPEESLIHSSAQIVSKHMVGADSLIGPDTQVGEKSSIKHSVIGSSCVIRDRVTVTNCLLMNSVTVEEGQ", "length": 403, "header": "tr|A0AAA9THE2-1|A0AAF6DMG9_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit gamma OS=Bos taurus OX=9913 GN=EIF2B3 PE=3 SV=1 CANONICAL=A0AAF6DMG9-1" }, "locus": { "chromosome": "3", "start_pos": 101172909, "end_pos": 101062109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098902.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098902.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095636.1" } ] } }, { "isoform_ac": "A0AAA9TUN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN0/entry", "sequence": { "sequence": "MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVITTKDVQKALCADFNKMKMKLDIVCIPDEADMGTADSLRHIYQKLKTDVLVLSCDLITDVALHEVVDLFRAHDASLAMLMRKGQESLEPVPGQKGKKKAVEQRDFVGVDSTGKRLLFMANEADLDEELIIKGSILQKSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLTLAPYDTCWNTCRGDSWEGLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVSKLLPVICPEESLIHSSAQIVSKHMVGADSLIGPDTQVGEKSSIKHSVIGSSCVIRDRVTVTNCLLMNSVTVEEGILLDGMTTVVSPWQGWNDTAPMSKSHLPPLSVPQKAEACKEWTYKTHSIFKGKLLCY", "length": 429, "header": "tr|A0AAA9TUN0-1|A0AAF6DMG9_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit gamma OS=Bos taurus OX=9913 GN=EIF2B3 PE=3 SV=1 CANONICAL=A0AAF6DMG9-1" }, "locus": { "chromosome": "3", "start_pos": 101153107, "end_pos": 101062109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135671.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135671.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102337.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102337.1" } ] } }, { "isoform_ac": "A0AAA9U1I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I8/entry", "sequence": { "sequence": "MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVITTKDVQKALCADFNKMKMKLDIVCIPDEADMGTADSLRHIYQKLKTDVLVLSCDLITDVALHEVVDLFRAHDASLAMLMRKGQESLEPVPGQKGKKKAVEQRDFVGVDSTGKRLLFMANEADLDEELIIKGSILQKHPRIRFHTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLTLAPYDTCWNTCRGDSWEGLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVSKLLPVICPEESLIHSSAQIVSKHMVGADSLIGPDTQVGEKSSIKHSVIGSSCVIRDRVTVTNCLLMNSVTVEEGILLDGMTTVVSPWQGWNDTAPMSKSHLPPLSVPQKAEACKEWTYKTHSIFKGKLLCY", "length": 459, "header": "tr|A0AAA9U1I8-1|A0AAF6DMG9_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit gamma OS=Bos taurus OX=9913 GN=EIF2B3 PE=3 SV=1 CANONICAL=A0AAF6DMG9-1" }, "locus": { "chromosome": "3", "start_pos": 101153107, "end_pos": 101062109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116343.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116343.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103666.1" } ] } }, { "isoform_ac": "A0AAF6DMG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9/entry", "sequence": { "sequence": "MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEELVSTVIQDNPGRISEHNMRTTTCLIVFTENLYVPEVIVITTKDVQKALCADFNKMKMKLDIVCIPDEADMGTADSLRHIYQKLKTDVLVLSCDLITDVALHEVVDLFRAHDASLAMLMRKGQESLEPVPGQKGKKKAVEQRDFVGVDSTGKRLLFMANEADLDEELIIKGSILQKHPRIRFHTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYLVRKQFSSASSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLTLAPYDTCWNTCRGDSWEGLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVSKLLPVICPEESLIHSSAQIVSKHMVGADSLIGPDTQVGEKSSIKHSVIGSSCVIRDRVTVTNCLLMNSVTVEEGSNIQSSIICNDAVIEKGADIKNCLIGSGQRIEAKAKRVNVIVGNDQFLEI", "length": 487, "header": "tr|A0AAF6DMG9-1|A0AAF6DMG9_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit gamma OS=Bos taurus OX=9913 GN=EIF2B3 PE=3 SV=1 CANONICAL=A0AAF6DMG9-1" }, "locus": { "chromosome": "3", "start_pos": 101172952, "end_pos": 101062109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056740.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056740.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049588.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049588.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 2B complex", "id": "GO:0005851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005851", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" }, { "name": "translation factor activity, RNA binding", "id": "GO:0008135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008135", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cytoplasmic translational initiation", "id": "GO:0002183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002183", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" }, { "name": "oligodendrocyte development", "id": "GO:0014003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" }, { "name": "positive regulation of translational initiation", "id": "GO:0045948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045948", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMG9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" }, { "id": "PF25084", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25084" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EIF2B subunit epsilon/gamma LbH", "eco_id": "ECO_0000259", "start_pos": 380, "end_pos": 471, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMG9" }, { "id": "PF00483", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00483" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleotidyl transferase", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 168, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YHF0-1", "uniprot_ac": "A0AAF6YHF0", "uniprot_id": "A0AAF6YHF0_BOVIN", "mass": { "chemical_mass": 15226.0, "monoisotopic_mass": 15226.0 }, "refseq": {}, "gene_names": [ { "name": "S100A2", "type": "recommended", "evidence": [ { "id": "A0AAF6YHF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" } ] } ], "protein_names": [ { "name": "Protein S100", "type": "recommended", "evidence": [ { "id": "A0AAF6YHF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAF6YHF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100A2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0", "locus": { "chromosome": "3", "start_pos": 16812657, "end_pos": 16807559, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037651", "url": "https://www.ensembl.org/id/ENSBTAG00000037651" } ] } } ], "crossref": [ { "id": "A0AAF6YHF0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YHF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9THS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AE17", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AE17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AMQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AMQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AMQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AMQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLWAPSMVGGDMRPFQIQRKVYPLPHPPSVRWSLRSKMSSPLEQALAVMVATFHKYSGQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGDLDENSDQQVDFQEYAVFLALITIMCNDFFQGSPARS", "length": 134, "header": "tr|A0AAF6YHF0-1|A0AAF6YHF0_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100A2 PE=3 SV=1 CANONICAL=A0AAF6YHF0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS6/entry", "sequence": { "sequence": "MSSPLEQALAVMVATFHKYSGQEGDKFKLSKGEMKELLHKELPSFVGKVDEEGLKKLMGDLDENSDQQVDFQEYAVFLALITIMCNDFFQGSPARS", "length": 96, "header": "tr|A0AAA9THS6-1|A0AAF6YHF0_BOVIN Computationally mapped isoform of Protein S100 OS=Bos taurus OX=9913 GN=S100A2 PE=3 SV=1 CANONICAL=A0AAF6YHF0-1" }, "locus": { "chromosome": "3", "start_pos": 16811723, "end_pos": 16809920, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123767.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123767.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096643.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096643.1" } ] } }, { "isoform_ac": "A0AAF6YHF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0/entry", "sequence": { "sequence": "MLWAPSMVGGDMRPFQIQRKVYPLPHPPSVRWSLRSKMSSPLEQALAVMVATFHKYSGQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGDLDENSDQQVDFQEYAVFLALITIMCNDFFQGSPARS", "length": 134, "header": "tr|A0AAF6YHF0-1|A0AAF6YHF0_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100A2 PE=3 SV=1 CANONICAL=A0AAF6YHF0-1" }, "locus": { "chromosome": "3", "start_pos": 16811723, "end_pos": 16809654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000589.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000589.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000589.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000589.3" } ] } }, { "isoform_ac": "A0AAF7AE17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE17/entry", "sequence": { "sequence": "MVSEEIQKFLDLRSKMSSPLEQALAVMVATFHKYSGQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGDLDENSDQQVDFQEYAVFLALITIMCNDFFQGSPARS", "length": 112, "header": "tr|A0AAF7AE17-1|A0AAF7AE17_BOVIN Computationally mapped isoform of Protein S100 OS=Bos taurus OX=9913 GN=S100A2 PE=3 SV=2 CANONICAL=A0AAF6YHF0-1" }, "locus": { "chromosome": "3", "start_pos": 16811723, "end_pos": 16796339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084523.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084523.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067363.3", "url": "https://www.ensembl.org/id/ENSBTAP00000067363.3" } ] } }, { "isoform_ac": "A0AAF7AMQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AMQ9/entry", "sequence": { "sequence": "MEKQIFDSSYTLKSLNDVMVSEEIQKFLDLRSKMSSPLEQALAVMVATFHKYSGQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGDLDENSDQQVDFQEYAVFLALITIMCNDFFQGSPARS", "length": 130, "header": "tr|A0AAF7AMQ9-1|A0AAF7AMQ9_BOVIN Computationally mapped isoform of Protein S100 OS=Bos taurus OX=9913 GN=S100A2 PE=3 SV=2 CANONICAL=A0AAF6YHF0-1" }, "locus": { "chromosome": "3", "start_pos": 16811723, "end_pos": 16785177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072619.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072619.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071742.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071742.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transition metal ion binding", "id": "GO:0046914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046914", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YHF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF0" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 122, "start_aa": "Val", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMA1-1", "uniprot_ac": "A0AAF6DMA1", "uniprot_id": "A0AAF6DMA1_BOVIN", "mass": { "chemical_mass": 75530.0, "monoisotopic_mass": 75530.0 }, "refseq": {}, "gene_names": [ { "name": "LOC507055", "type": "recommended", "evidence": [ { "id": "A0AAF6DMA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ] } ], "protein_names": [ { "name": "GB1/RHD3-type G domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6DMA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC507055", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1", "locus": {} } ], "crossref": [ { "id": "A0AAF6DMA1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002416", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002416", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01851", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01851", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507055", "url": "https://www.ncbi.nlm.nih.gov/gene/507055", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036543", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783604", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783604", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCDMDDQ", "url": "https://omabrowser.org/oma/group/LCDMDDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAL7", "url": "https://www.orthodb.org/?gene=E1BAL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10751", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02263", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9948001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9948001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9953170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9953170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9THZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL7", "url": "https://www.uniprot.org/uniprotkb/E1BAL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSKMIADSDCSREIKKTLAPWKESYDNLDNILKSRDVTLPTKIPMTSRATKMDPICLVENRKNQLSVNPKALKILDEISQPLVVVAIVGLYRTGKSYLMNRLAEQNHGFRLGSTVRSETKGIWMWCVPHPSKENHILVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTFIFNSMNSINDQALQQLHYVTELTELIRTKSSPSSDEVEDSARFVSFFPDFIWTVRDFMLELELDGSSITEDEYLENALKLIPDKGPQIQNFNLPRECIRKFFPKRKCFVFDRPASNKRQLLHLEEMPDNQLDENFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQQLSLPTDTLQELLEVHAACEKEAIAVFMECSFKDENQDFQLKLAIMINKKKDDFLLQNEEASVRYCQAELKKLSEPLMTSISEGTFSVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKADQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQLKEKFEVERENLLREQEAVLAHKLKVQEEMLAEGFERKASELHEEILRLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNRV", "length": 660, "header": "tr|A0AAF6DMA1-1|A0AAF6DMA1_BOVIN Isoform 1 of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC507055 PE=3 SV=2 CANONICAL=A0AAF6DMA1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THZ2/entry", "sequence": { "sequence": "MIPMTSRATKMDPICLVENRKNQLSVNPKALKILDEISQPLVVVAIVGLYRTGKSYLMNRLAEQNHGFRLGSTVRSETKGIWMWCVPHPSKENHILVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTFIFNSMNSINDQALQQLHYVTELTELIRTKSSPSSDEVEDSARFVSFFPDFIWTVRDFMLELELDGSSITEDEYLENALKLIPDKGPQIQNFNLPRECIRKFFPKRKCFVFDRPASNKRQLLHLEEMPDNQLDENFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQQLSLPTDTLQELLEVHAACEKEAIAVFMECSFKDENQDFQLKLAIMINKKKDDFLLQNEEASVRYCQAELKKLSEPLMTSISEGTFSVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKADQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQLKEKFEVERENLLREQEAVLAHKLKVQEEMLAEGFERKASELHEEILRLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNRV", "length": 618, "header": "tr|A0AAA9THZ2-1|A0AAF6DMA1_BOVIN Computationally mapped isoform of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC507055 PE=3 SV=2 CANONICAL=A0AAF6DMA1-1" }, "locus": { "chromosome": "3", "start_pos": 54781233, "end_pos": 54722498, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100736.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100736.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096720.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096720.2" } ] } }, { "isoform_ac": "A0AAF6DMA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1/entry", "sequence": { "sequence": "MGSKMIADSDCSREIKKTLAPWKESYDNLDNILKSRDVTLPTKIPMTSRATKMDPICLVENRKNQLSVNPKALKILDEISQPLVVVAIVGLYRTGKSYLMNRLAEQNHGFRLGSTVRSETKGIWMWCVPHPSKENHILVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTFIFNSMNSINDQALQQLHYVTELTELIRTKSSPSSDEVEDSARFVSFFPDFIWTVRDFMLELELDGSSITEDEYLENALKLIPDKGPQIQNFNLPRECIRKFFPKRKCFVFDRPASNKRQLLHLEEMPDNQLDENFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQQLSLPTDTLQELLEVHAACEKEAIAVFMECSFKDENQDFQLKLAIMINKKKDDFLLQNEEASVRYCQAELKKLSEPLMTSISEGTFSVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKADQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQLKEKFEVERENLLREQEAVLAHKLKVQEEMLAEGFERKASELHEEILRLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNRV", "length": 660, "header": "tr|A0AAF6DMA1-1|A0AAF6DMA1_BOVIN Isoform 1 of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC507055 PE=3 SV=2 CANONICAL=A0AAF6DMA1-1" }, "locus": { "chromosome": "3", "start_pos": 54781233, "end_pos": 54744208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052710.5", "url": "https://www.ensembl.org/id/ENSBTAT00000052710.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052290.5", "url": "https://www.ensembl.org/id/ENSBTAP00000052290.5" } ] } }, { "isoform_ac": "E1BAL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL7/entry", "sequence": { "sequence": "MTSRATKMDPICLVENRKNQLSVNPKALKILDEISQPLVVVAIVGLYRTGKSYLMNRLAEQNHGFRLGSTVRSETKGIWMWCVPHPSKENHILVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTFIFNSMNSINDQALQQLHYVTELTELIRTKSSPSSDEVEDSARFVSFFPDFIWTVRDFMLELELDGSSITEDEYLENALKLIPDKGPQIQNFNLPRECIRKFFPKRKCFVFDRPASNKRQLLHLEEMPDNQLDENFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQQLSLPTDTLQELLEVHAACEKEAIAVFMECSFKDENQDFQLKLAIMINKKKDDFLLQNEEASVRYCQAELKKLSEPLMTSISEGTFSVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKADQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQLKEKFEVERENLLREQEAVLAHKLKVQEEMLAEGFERKASELHEEILRLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNRV", "length": 615, "header": "tr|E1BAL7-1|E1BAL7_BOVIN Computationally mapped isoform of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC507055 PE=3 SV=4 CANONICAL=A0AAF6DMA1-1" }, "locus": { "chromosome": "3", "start_pos": 54781233, "end_pos": 54746194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019081.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019081.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019081.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019081.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783604", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783604", "resource": "KEGG Pathway" }, { "id": "R-BTA-9948001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9948001", "resource": "Reactome", "description": "CASP4 inflammasome assembly" }, { "id": "R-BTA-9953170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9953170", "resource": "Reactome", "description": "GBP-mediated host defense" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JDV3-1", "protein_name": "Guanylate-binding protein 6", "gene_name": "Gbp6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLQYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL", "length": 611 }, "evidence": [ { "id": "A0AAF6DMA1", "url": "https://omabrowser.org/oma/group/A0AAF6DMA1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N8V2-1", "protein_name": "Guanylate-binding protein 7", "gene_name": "GBP7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS", "length": 638 }, "evidence": [ { "id": "A0AAF6DMA1", "url": "https://omabrowser.org/oma/group/A0AAF6DMA1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" }, { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" }, { "name": "defense response to protozoan", "id": "GO:0042832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA1" }, { "id": "PS51715", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51715" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GB1/RHD3-type G", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 322, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YGQ3-1", "uniprot_ac": "A0AAF6YGQ3", "uniprot_id": "A0AAF6YGQ3_BOVIN", "mass": { "chemical_mass": 37884.0, "monoisotopic_mass": 37884.0 }, "refseq": {}, "gene_names": [ { "name": "AHSG", "type": "recommended", "evidence": [ { "id": "A0AAF6YGQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ] } ], "protein_names": [ { "name": "Alpha-2-HS-glycoprotein", "type": "recommended", "evidence": [ { "id": "A0AAF6YGQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3/entry#names_and_taxonomy" } ] }, { "name": "Fetuin-A", "type": "synonym", "evidence": [ { "id": "A0AAF6YGQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AHSG", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3", "locus": { "chromosome": "1", "start_pos": 80611224, "end_pos": 80630409, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000522", "url": "https://www.ensembl.org/id/ENSBTAG00000000522" } ] } } ], "crossref": [ { "id": "A0AAF6YGQ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YGQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13814:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13814:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TI62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSFVLLFCLAQLWGCHSIPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI", "length": 354, "header": "tr|A0AAF6YGQ3-1|A0AAF6YGQ3_BOVIN Isoform 1 of Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=4 SV=1 CANONICAL=A0AAF6YGQ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TI62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI62/entry", "sequence": { "sequence": "MEPTFLMSPALTGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI", "length": 346, "header": "tr|A0AAA9TI62-1|A0AAF6YGQ3_BOVIN Computationally mapped isoform of Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=4 SV=1 CANONICAL=A0AAF6YGQ3-1" }, "locus": { "chromosome": "1", "start_pos": 80630339, "end_pos": 80612228, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093516.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093516.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096795.1" } ] } }, { "isoform_ac": "A0AAF6YGQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3/entry", "sequence": { "sequence": "MKSFVLLFCLAQLWGCHSIPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI", "length": 354, "header": "tr|A0AAF6YGQ3-1|A0AAF6YGQ3_BOVIN Isoform 1 of Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=4 SV=1 CANONICAL=A0AAF6YGQ3-1" }, "locus": { "chromosome": "1", "start_pos": 80618760, "end_pos": 80612228, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000673.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000673.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000673.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000673.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 275, "start_aa": "Thr", "end_pos": 275, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr275", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis", "id": "GO:0050766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" }, { "name": "negative regulation of bone mineralization", "id": "GO:0030502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030502", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YGQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGQ3" }, { "id": "PS51529", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51529" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin fetuin-A-type", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 133, "start_aa": "Tyr", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 275 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJN9-1", "uniprot_ac": "A0AAF6YJN9", "uniprot_id": "A0AAF6YJN9_BOVIN", "mass": { "chemical_mass": 23376.0, "monoisotopic_mass": 23376.0 }, "refseq": {}, "gene_names": [ { "name": "PRAF2", "type": "recommended", "evidence": [ { "id": "A0AAF6YJN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ] } ], "protein_names": [ { "name": "PRA1 family protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YJN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRAF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9", "locus": { "chromosome": "X", "start_pos": 87153480, "end_pos": 87156389, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002562", "url": "https://www.ensembl.org/id/ENSBTAG00000002562" } ] } } ], "crossref": [ { "id": "A0AAF6YJN9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12859:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12859:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TIL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSRWVFRVAAEGSRLHFPVCPVLARGGTGVVVRPLLWSSYIDRQDVGGAAATATRLGRLRFGVRASGGPGSLRPAAMVPPRHQQPPLLPNQLPYLLRPWYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 218, "header": "tr|A0AAF6YJN9-1|A0AAF6YJN9_BOVIN Isoform 1 of PRA1 family protein OS=Bos taurus OX=9913 GN=PRAF2 PE=3 SV=1 CANONICAL=A0AAF6YJN9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIL5/entry", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLVAPDPCDPQRWCHRVINNLLYYQTNYLICFGLGLALAGYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLRESSLPDNRENSQRSRTAPGPPYRFLG", "length": 159, "header": "tr|A0AAA9TIL5-1|A0AAF6YJN9_BOVIN Computationally mapped isoform of PRA1 family protein OS=Bos taurus OX=9913 GN=PRAF2 PE=3 SV=1 CANONICAL=A0AAF6YJN9-1" }, "locus": { "chromosome": "X", "start_pos": 87156100, "end_pos": 87154645, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091836.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091836.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096748.1" } ] } }, { "isoform_ac": "A0AAF6YJN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9/entry", "sequence": { "sequence": "MRSRWVFRVAAEGSRLHFPVCPVLARGGTGVVVRPLLWSSYIDRQDVGGAAATATRLGRLRFGVRASGGPGSLRPAAMVPPRHQQPPLLPNQLPYLLRPWYVRPLHTLLSALVVAVALGMLVCAAENRAAVRRCRRSHPAACLAAVLAVGFLVLWAAGGAGTFLLSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 218, "header": "tr|A0AAF6YJN9-1|A0AAF6YJN9_BOVIN Isoform 1 of PRA1 family protein OS=Bos taurus OX=9913 GN=PRAF2 PE=3 SV=1 CANONICAL=A0AAF6YJN9-1" }, "locus": { "chromosome": "X", "start_pos": 87156236, "end_pos": 87154158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003318.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003318.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003318.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003318.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJN9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM94-1", "uniprot_ac": "A0AAF6DM94", "uniprot_id": "A0AAF6DM94_BOVIN", "mass": { "chemical_mass": 37481.0, "monoisotopic_mass": 37481.0 }, "refseq": {}, "gene_names": [ { "name": "GLOD4", "type": "recommended", "evidence": [ { "id": "A0AAF6DM94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94" } ] } ], "protein_names": [ { "name": "Glyoxalase domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "A0AAF6DM94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLOD4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94", "locus": { "chromosome": "19", "start_pos": 22082900, "end_pos": 22065122, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019160", "url": "https://www.ensembl.org/id/ENSBTAG00000019160" } ] } } ], "crossref": [ { "id": "A0AAF6DM94", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM94", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08358", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08358", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16357", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16357", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR029068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46466:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46466:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TK47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P357", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P357", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P357-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P357-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANRRALHFVFKVGNRFETACFYRDVLGMKILRHEEFQDGCKAACNGPYDGKWSKTMVGYGPEDDHFVTELTYNYGIGSYQLGNDFLGITVASRQAVSNARKLKWPLSEMGDGVFETKAPGGYKFYLQDCSPPQSDPVLKVTLAVSDLQKSLNYWSNLLGMKIYEEDEKKQRALLGYADNQCKLELRAIPGKVDHATGFGRIAFSCPQKELSDLEDLMKRENQKILTPLVSLDTPGKATVQVIILADPDGHEICFVGDEAFRELSKVDPEGNKLLDDGFPGGSVVKNLPANVGDAGSIPEFGRSPGRGHGNPLQYSCLENPMSRGAWWTEVHGVAKSQT", "length": 339, "header": "tr|A0AAF6DM94-1|A0AAF6DM94_BOVIN Isoform 1 of Glyoxalase domain-containing protein 4 OS=Bos taurus OX=9913 GN=GLOD4 PE=1 SV=1 CANONICAL=A0AAF6DM94-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TK47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK47/entry", "sequence": { "sequence": "MANRRALHFVFKVGNRFETACFYRDVLGMKILRHEEFQDGCKAACNGPYDGKWSKTMVGYGPEDDHFVTELTYNYGIGSYQLGNDFLGITVASRQAVSNARKLKWPLSEMGDGVFETKAPGGYKFYLQDCSPPQSDPVLKVTLAVSDLQKSLNYWSNLLGMKIYEEDEKKQRALLGYADNQCKLELRAIPGKVDHATGFGRIAFSCPQKELSDLEDLMKRENQKILTPLVSLDTPGKATVQVIILADPDGHEICFVGDEAFRELSKVDPEGNKLLDDNMRRKTEEVHQIVPHSDKAPEEGSEGCHSR", "length": 307, "header": "tr|A0AAA9TK47-1|A0AAF6DM94_BOVIN Computationally mapped isoform of Glyoxalase domain-containing protein 4 OS=Bos taurus OX=9913 GN=GLOD4 PE=1 SV=1 CANONICAL=A0AAF6DM94-1" }, "locus": { "chromosome": "19", "start_pos": 22078451, "end_pos": 22065128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103697.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103697.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098742.1" } ] } }, { "isoform_ac": "A0AAF6DM94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94/entry", "sequence": { "sequence": "MANRRALHFVFKVGNRFETACFYRDVLGMKILRHEEFQDGCKAACNGPYDGKWSKTMVGYGPEDDHFVTELTYNYGIGSYQLGNDFLGITVASRQAVSNARKLKWPLSEMGDGVFETKAPGGYKFYLQDCSPPQSDPVLKVTLAVSDLQKSLNYWSNLLGMKIYEEDEKKQRALLGYADNQCKLELRAIPGKVDHATGFGRIAFSCPQKELSDLEDLMKRENQKILTPLVSLDTPGKATVQVIILADPDGHEICFVGDEAFRELSKVDPEGNKLLDDGFPGGSVVKNLPANVGDAGSIPEFGRSPGRGHGNPLQYSCLENPMSRGAWWTEVHGVAKSQT", "length": 339, "header": "tr|A0AAF6DM94-1|A0AAF6DM94_BOVIN Isoform 1 of Glyoxalase domain-containing protein 4 OS=Bos taurus OX=9913 GN=GLOD4 PE=1 SV=1 CANONICAL=A0AAF6DM94-1" }, "locus": { "chromosome": "19", "start_pos": 22082730, "end_pos": 22065128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025501.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025501.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025501.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025501.7" } ] } }, { "isoform_ac": "A0ABI0P357-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P357/entry", "sequence": { "sequence": "MLAPESAASVAAPGDWPLPLPSEAVSRDRASVPQPHQMETALSRGSAAVPGPSAAHRGPKPAPPAAKILRHEEFQDGCKAACNGPYDGKWSKTMVGYGPEDDHFVTELTYNYGIGSYQLGNDFLGITVASRQAVSNARKLKWPLSEMGDGVFETKAPGGYKFYLQDCSPPQSDPVLKVTLAVSDLQKSLNYWSNLLGMKIYEEDEKKQRALLGYADNQCKLELRAIPGKVDHATGFGRIAFSCPQKELSDLEDLMKRENQKILTPLVSLDTPGKATVQVIILADPDGHEICFVGDEAFRELSKVDPEGNKLLDDAISGDKSDEWFAAQKKPKATG", "length": 335, "header": "tr|A0ABI0P357-1|A0ABI0P357_BOVIN Computationally mapped isoform of Glyoxalase domain containing 4 OS=Bos taurus OX=9913 GN=GLOD4 PE=1 SV=1 CANONICAL=A0AAF6DM94-1" }, "locus": { "chromosome": "19", "start_pos": 22084164, "end_pos": 22064761, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143196.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143196.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107745.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM94" }, { "id": "PS51819", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51819" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VOC", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 130, "start_aa": "Arg", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YYF2-1", "uniprot_ac": "A0AAF6YYF2", "uniprot_id": "A0AAF6YYF2_BOVIN", "mass": { "chemical_mass": 89963.0, "monoisotopic_mass": 89963.0 }, "refseq": {}, "gene_names": [ { "name": "COG4", "type": "recommended", "evidence": [ { "id": "A0AAF6YYF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2" } ] } ], "protein_names": [ { "name": "Conserved oligomeric Golgi complex subunit 4", "type": "recommended", "evidence": [ { "id": "A0AAF6YYF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2/entry#names_and_taxonomy" } ] }, { "name": "Component of oligomeric Golgi complex 4", "type": "synonym", "evidence": [ { "id": "A0AAF6YYF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2#function" }, { "database": "UniProtKB", "id": "ARBA00058172", "url": "https://www.uniprot.org/uniprotkb/ARBA00058172#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2", "locus": { "chromosome": "18", "start_pos": 1643268, "end_pos": 1617958, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012988", "url": "https://www.ensembl.org/id/ENSBTAG00000012988" } ] } } ], "crossref": [ { "id": "A0AAF6YYF2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YYF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24016:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24016:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTKMADLDSPQKLSGVPRPPDGVGGGSCSEISTELIRSLTDLQELEAVYERLCGEEDVSLFQKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYRQQFRHVQSNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCHKLRMGFPATTLQDIQRGVTSAVSIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSGKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFSDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 795, "header": "tr|A0AAF6YYF2-1|A0AAF6YYF2_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 4 OS=Bos taurus OX=9913 GN=COG4 PE=3 SV=2 CANONICAL=A0AAF6YYF2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TMB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMB7/entry", "sequence": { "sequence": "MGTKMADLDSPQKLSGVPRPPDGVGGGSCSEISTELIRSLTDLQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYRQQFRHVQSNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCHKLRMGFPATTLQDIQRGVTSAVSIMHSSLQQGKFDTKGIESTDEAKLSFLSDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSGKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFSDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 768, "header": "tr|A0AAA9TMB7-1|A0AAF6YYF2_BOVIN Computationally mapped isoform of Conserved oligomeric Golgi complex subunit 4 OS=Bos taurus OX=9913 GN=COG4 PE=3 SV=1 CANONICAL=A0AAF6YYF2-1" }, "locus": { "chromosome": "18", "start_pos": 1642935, "end_pos": 1618157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115583.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115583.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098131.1" } ] } }, { "isoform_ac": "A0AAF6YYF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2/entry", "sequence": { "sequence": "MGTKMADLDSPQKLSGVPRPPDGVGGGSCSEISTELIRSLTDLQELEAVYERLCGEEDVSLFQKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYRQQFRHVQSNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCHKLRMGFPATTLQDIQRGVTSAVSIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSGKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFSDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 795, "header": "tr|A0AAF6YYF2-1|A0AAF6YYF2_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 4 OS=Bos taurus OX=9913 GN=COG4 PE=3 SV=2 CANONICAL=A0AAF6YYF2-1" }, "locus": { "chromosome": "18", "start_pos": 1642935, "end_pos": 1618157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017269.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017269.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017269.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017269.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YYF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYF2" }, { "id": "SM00762", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00762" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COG4 transport protein middle alpha-helical bundle", "eco_id": "ECO_0000259", "start_pos": 198, "end_pos": 508, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 351, "end_pos": 353 }, { "start_pos": 567, "end_pos": 569 }, { "start_pos": 622, "end_pos": 624 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YYM1-1", "uniprot_ac": "A0AAF6YYM1", "uniprot_id": "A0AAF6YYM1_BOVIN", "mass": { "chemical_mass": 19537.0, "monoisotopic_mass": 19537.0 }, "refseq": {}, "gene_names": [ { "name": "FABP7", "type": "recommended", "evidence": [ { "id": "A0AAF6YYM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1" } ] } ], "protein_names": [ { "name": "Fatty acid binding protein 7", "type": "synonym", "evidence": [ { "id": "A0AAF6YYM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FABP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1", "locus": { "chromosome": "9", "start_pos": 28476075, "end_pos": 28479847, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033803", "url": "https://www.ensembl.org/id/ENSBTAG00000033803" } ] } } ], "crossref": [ { "id": "A0AAF6YYM1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YYM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11955", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11955", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TTY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEAFCATWKLTESQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDRVVIRTQSTFKNTEISFHLGEEFDETTADDRNCKSVVSLDGDKLVHVQKWDGKETNFVREIKDGKMIMIWLSLESFRLLLLAMWLLFAIMRRHRKHPDLGLEKLYNISVYSSLSVKLLLQCG", "length": 170, "header": "tr|A0AAF6YYM1-1|A0AAF6YYM1_BOVIN Isoform 1 of Fatty acid binding protein 7 OS=Bos taurus OX=9913 GN=FABP7 PE=3 SV=1 CANONICAL=A0AAF6YYM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TTY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTY7/entry", "sequence": { "sequence": "MVEAFCATWKLTESQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDRVVIRTQSTFKNTEISFHLGEEFDETTADDRNCKSVVSLDGDKLVHVQKWDGKETNFVREIKDGKMIMVTLVCMTVIRHD", "length": 128, "header": "tr|A0AAA9TTY7-1|A0AAF6YYM1_BOVIN Computationally mapped isoform of Fatty acid binding protein 7 OS=Bos taurus OX=9913 GN=FABP7 PE=3 SV=1 CANONICAL=A0AAF6YYM1-1" }, "locus": { "chromosome": "9", "start_pos": 28479752, "end_pos": 28477387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119102.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119102.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100852.1" } ] } }, { "isoform_ac": "A0AAF6YYM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1/entry", "sequence": { "sequence": "MVEAFCATWKLTESQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDRVVIRTQSTFKNTEISFHLGEEFDETTADDRNCKSVVSLDGDKLVHVQKWDGKETNFVREIKDGKMIMIWLSLESFRLLLLAMWLLFAIMRRHRKHPDLGLEKLYNISVYSSLSVKLLLQCG", "length": 170, "header": "tr|A0AAF6YYM1-1|A0AAF6YYM1_BOVIN Isoform 1 of Fatty acid binding protein 7 OS=Bos taurus OX=9913 GN=FABP7 PE=3 SV=1 CANONICAL=A0AAF6YYM1-1" }, "locus": { "chromosome": "9", "start_pos": 28479752, "end_pos": 28476297, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017593.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017593.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017593.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017593.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YYM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYM1" }, { "id": "PS00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cytosolic fatty-acid binding proteins", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 24, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 35, "end_pos": 37 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YW85-1", "uniprot_ac": "A0AAF6YW85", "uniprot_id": "A0AAF6YW85_BOVIN", "mass": { "chemical_mass": 41464.0, "monoisotopic_mass": 41464.0 }, "refseq": {}, "gene_names": [ { "name": "CNN1", "type": "recommended", "evidence": [ { "id": "A0AAF6YW85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ] } ], "protein_names": [ { "name": "Calponin", "type": "recommended", "evidence": [ { "id": "A0AAF6YW85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TV76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV76#function" }, { "database": "UniProtKB", "id": "RU361224", "url": "https://www.uniprot.org/uniprotkb/RU361224#function" }, { "database": "UniProtKB", "id": "ARBA00025109", "url": "https://www.uniprot.org/uniprotkb/ARBA00025109#function" }, { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85", "locus": { "chromosome": "7", "start_pos": 15891278, "end_pos": 15882825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011207", "url": "https://www.ensembl.org/id/ENSBTAG00000011207" } ] } } ], "crossref": [ { "id": "A0AAF6YW85", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YW85", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21282", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21282", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TV76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQSAPNTKALTSRSGGGRGGGRPAPWQVPTANGTVLEEARAASRASKTCEEGRGCRRSFSCCRRPQRAATAAHPPSTSMSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHPHNYYNSA", "length": 376, "header": "tr|A0AAF6YW85-1|A0AAF6YW85_BOVIN Isoform 1 of Calponin OS=Bos taurus OX=9913 GN=CNN1 PE=3 SV=1 CANONICAL=A0AAF6YW85-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TV76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV76/entry", "sequence": { "sequence": "MTSETWRDGLRDRQIEIKRPSRRPSKQGRVGQRWSLAKQLKGKSLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHPHNYYNSA", "length": 320, "header": "tr|A0AAA9TV76-1|A0AAF6YW85_BOVIN Computationally mapped isoform of Calponin OS=Bos taurus OX=9913 GN=CNN1 PE=3 SV=1 CANONICAL=A0AAF6YW85-1" }, "locus": { "chromosome": "7", "start_pos": 15890770, "end_pos": 15882876, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087610.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087610.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102265.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102265.1" } ] } }, { "isoform_ac": "A0AAF6YW85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85/entry", "sequence": { "sequence": "MTQSAPNTKALTSRSGGGRGGGRPAPWQVPTANGTVLEEARAASRASKTCEEGRGCRRSFSCCRRPQRAATAAHPPSTSMSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKVNESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHPHNYYNSA", "length": 376, "header": "tr|A0AAF6YW85-1|A0AAF6YW85_BOVIN Isoform 1 of Calponin OS=Bos taurus OX=9913 GN=CNN1 PE=3 SV=1 CANONICAL=A0AAF6YW85-1" }, "locus": { "chromosome": "7", "start_pos": 15890770, "end_pos": 15883277, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014883.8", "url": "https://www.ensembl.org/id/ENSBTAT00000014883.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014883.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014883.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actomyosin structure organization", "id": "GO:0031032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031032", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904706", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YW85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW85" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 107, "end_pos": 210, "start_aa": "His", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YTI3-1", "uniprot_ac": "A0AAF6YTI3", "uniprot_id": "A0AAF6YTI3_BOVIN", "mass": { "chemical_mass": 22402.0, "monoisotopic_mass": 22402.0 }, "refseq": {}, "gene_names": [ { "name": "SHISAL2B", "type": "recommended", "evidence": [ { "id": "A0AAF6YTI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3" } ] } ], "protein_names": [ { "name": "Shisa like 2B", "type": "synonym", "evidence": [ { "id": "A0AAF6YTI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHISAL2B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3", "locus": { "chromosome": "20", "start_pos": 14767967, "end_pos": 14790737, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009468", "url": "https://www.ensembl.org/id/ENSBTAG00000009468" } ] } } ], "crossref": [ { "id": "A0AAF6YTI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YTI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31395", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31395:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TVT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEASRVCSGYYSLNHSFVEPFQCPRRGEGATLLYCCGFADLKYCCSEPGSYFPYKHSYMWSLSIGALIGLGIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEAVSTQEGMMLKLKLQYFGHLMRSFDSLEKTLMLGGIGGRRRRQRQRMRWLDGITDSMDATQIEKAKPPVQMQHQIQQMKRSMRLMT", "length": 196, "header": "tr|A0AAF6YTI3-1|A0AAF6YTI3_BOVIN Isoform 1 of Shisa like 2B OS=Bos taurus OX=9913 GN=SHISAL2B PE=4 SV=1 CANONICAL=A0AAF6YTI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TVT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT7/entry", "sequence": { "sequence": "MPGDQSEARAEAAQATRPGRNRADCSALLSPSSGDQSQVRGSAGHRLTDNLRSIGALIGLGIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEAVSTQEGNSNRKSKAPRSNAASNSTNETFYEADDIIQEKTMDTTQINTAYC", "length": 150, "header": "tr|A0AAA9TVT7-1|A0AAF6YTI3_BOVIN Computationally mapped isoform of Shisa like 2B OS=Bos taurus OX=9913 GN=SHISAL2B PE=4 SV=1 CANONICAL=A0AAF6YTI3-1" }, "locus": { "chromosome": "20", "start_pos": 14790167, "end_pos": 14768037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102340.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102340.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100711.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100711.1" } ] } }, { "isoform_ac": "A0AAF6YTI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3/entry", "sequence": { "sequence": "MSEASRVCSGYYSLNHSFVEPFQCPRRGEGATLLYCCGFADLKYCCSEPGSYFPYKHSYMWSLSIGALIGLGIAALVLLAFVISVCVLCYLFLYTKPQRLDTGLKLQHLEAVSTQEGMMLKLKLQYFGHLMRSFDSLEKTLMLGGIGGRRRRQRQRMRWLDGITDSMDATQIEKAKPPVQMQHQIQQMKRSMRLMT", "length": 196, "header": "tr|A0AAF6YTI3-1|A0AAF6YTI3_BOVIN Isoform 1 of Shisa like 2B OS=Bos taurus OX=9913 GN=SHISAL2B PE=4 SV=1 CANONICAL=A0AAF6YTI3-1" }, "locus": { "chromosome": "20", "start_pos": 14790574, "end_pos": 14768087, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012465.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012465.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012465.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012465.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YTI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTI3" }, { "id": "PF13908", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shisa N-terminal", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 51, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YGX9-1", "uniprot_ac": "A0AAF6YGX9", "uniprot_id": "A0AAF6YGX9_BOVIN", "mass": { "chemical_mass": 118352.0, "monoisotopic_mass": 118352.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Kynurenine--oxoglutarate transaminase 3", "type": "recommended", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.63", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.7", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "4.4.1.13", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "Cysteine-S-conjugate beta-lyase 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine aminotransferase 3", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine aminotransferase III", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine--glyoxylate transaminase", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine--oxoglutarate transaminase III", "type": "synonym", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9#function" }, { "database": "UniProtKB", "id": "ARBA00054518", "url": "https://www.uniprot.org/uniprotkb/ARBA00054518#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9", "locus": {} } ], "crossref": [ { "id": "A0AAF6YGX9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YGX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01851", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01851", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036543", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10751", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00155", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02263", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "18121", "url": "https://www.rhea-db.org/rhea/18121", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "65560", "url": "https://www.rhea-db.org/rhea/65560", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "65896", "url": "https://www.rhea-db.org/rhea/65896", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "65900", "url": "https://www.rhea-db.org/rhea/65900", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEIHMPGPECLIKNINGRLLVNPEALKILSAIRQPVVVVAIVGPYRTGKSYLMNKLAGKNKGFPLGSTVQSHTKGIWMWCVPHPKKPNRTLVLLDTEGLGDVEKGDNQNDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIRAKSSPDVDGVEDSADFVSFFPDFIWTLRDFSLDLEADGQSITADEYLENSLKLKKGTSPKDKTFNLPRLCIRKFFPKKKCFIFDRPTHRKKLGQLEELCDDELDSEFVQQAVVFCSYIFSNSKTKTLSGGIKVDGPRLGTLVQTYVNAINSGDLPCMENAVLALAEIENSAAVQKAIVHYDQQMGQKLQLPTETLQELLDLHRATEKETIEVFMRSSFKDIDQLFQKKLAAQLDKKRDDFCDQNRKASSDRCSALLKDIFSPLEEDVKQGIYSKSGGYRLFIEKMQELKKKYLQEPRKGIQAEEILQEYLKSKESVTDAILQTDQTLSEKEKLIEVERVRAESAQAAAKMQEEMQIKNQQMMEQKEKSYQEHVKQLTEKMERDRAQLLEEQERTLALKLQEQSRLLKEGFQEEQRRLQNEIQNLQKMMKEPSMFLAWERLCTLSCRPKFLKTVWASKILGLSTSAKMSLRFKNAKRIEGLDSNIWIEFTKLAADPSVVNLGQGLPDISPPVYVKEELSKIAAIDNLNQYTRGFGHPSLVKALSCLYEKFYHNKINPNEEILVTVGAYGSLFNAIQGLIDEGDEVIVIVPFFDCYESMVRMAGATPVFVPLRCKPVDGKKCSSSDWTLDPQELASKFNSKTKAIILNTPHNPLGKVYTKEELQVIADLCIKYDTLCISDEVYEWLVYTGNKHFKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPKHLIKHLQTVQQNTVYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVHLLESVGLKSIVPDGGYFIIADVSLLDVDLLDMKDSNEPYDYKFVKWMIKNKKLSAIPVSAFCNAETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSRQNS", "length": 1040, "header": "tr|A0AAF6YGX9-1|A0AAF6YGX9_BOVIN Isoform 1 of Kynurenine--oxoglutarate transaminase 3 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAF6YGX9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YGX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9/entry", "sequence": { "sequence": "MASEIHMPGPECLIKNINGRLLVNPEALKILSAIRQPVVVVAIVGPYRTGKSYLMNKLAGKNKGFPLGSTVQSHTKGIWMWCVPHPKKPNRTLVLLDTEGLGDVEKGDNQNDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIRAKSSPDVDGVEDSADFVSFFPDFIWTLRDFSLDLEADGQSITADEYLENSLKLKKGTSPKDKTFNLPRLCIRKFFPKKKCFIFDRPTHRKKLGQLEELCDDELDSEFVQQAVVFCSYIFSNSKTKTLSGGIKVDGPRLGTLVQTYVNAINSGDLPCMENAVLALAEIENSAAVQKAIVHYDQQMGQKLQLPTETLQELLDLHRATEKETIEVFMRSSFKDIDQLFQKKLAAQLDKKRDDFCDQNRKASSDRCSALLKDIFSPLEEDVKQGIYSKSGGYRLFIEKMQELKKKYLQEPRKGIQAEEILQEYLKSKESVTDAILQTDQTLSEKEKLIEVERVRAESAQAAAKMQEEMQIKNQQMMEQKEKSYQEHVKQLTEKMERDRAQLLEEQERTLALKLQEQSRLLKEGFQEEQRRLQNEIQNLQKMMKEPSMFLAWERLCTLSCRPKFLKTVWASKILGLSTSAKMSLRFKNAKRIEGLDSNIWIEFTKLAADPSVVNLGQGLPDISPPVYVKEELSKIAAIDNLNQYTRGFGHPSLVKALSCLYEKFYHNKINPNEEILVTVGAYGSLFNAIQGLIDEGDEVIVIVPFFDCYESMVRMAGATPVFVPLRCKPVDGKKCSSSDWTLDPQELASKFNSKTKAIILNTPHNPLGKVYTKEELQVIADLCIKYDTLCISDEVYEWLVYTGNKHFKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPKHLIKHLQTVQQNTVYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVHLLESVGLKSIVPDGGYFIIADVSLLDVDLLDMKDSNEPYDYKFVKWMIKNKKLSAIPVSAFCNAETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSRQNS", "length": 1040, "header": "tr|A0AAF6YGX9-1|A0AAF6YGX9_BOVIN Isoform 1 of Kynurenine--oxoglutarate transaminase 3 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAF6YGX9-1" }, "locus": { "chromosome": "3", "start_pos": 54988768, "end_pos": 54901270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000643.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000643.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000643.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000643.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ], "pmid": "" }, { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18121", "name": "", "equation": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TKC4-1", "A0AAF6YGX9-1", "Q0P5G4-1", "A0AAA9S197-1" ], "evidence": [ { "id": "18121", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18121" } ] }, { "id": "65560", "name": "", "equation": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TKC4-1", "A0AAF6YGX9-1", "Q5E9N4-1", "Q0P5G4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1", "A0AAA9S197-1" ], "evidence": [ { "id": "65560", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65560" } ] }, { "id": "65896", "name": "", "equation": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YGX9-1", "Q5E9N4-1", "Q0P5G4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "65896", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65896" } ] }, { "id": "65900", "name": "", "equation": "3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YGX9-1", "Q5E9N4-1", "Q0P5G4-1" ], "evidence": [ { "id": "65900", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65900" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LKR3", "gene_name": "AADAT", "activity": [ { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.39", "activity": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.4", "activity": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.73", "activity": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.63", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.73", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.39", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] } ] }, { "uniprot_ac": "A0AAA9S197", "gene_name": "LOC104968656", "activity": [ { "ec_number": "2.6.1.64", "activity": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "4.4.1.13", "activity": "", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "2.6.1.64", "activity": "", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] } ] }, { "uniprot_ac": "A0AAA9S9L4", "gene_name": "", "activity": [ { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.39", "activity": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.4", "activity": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.73", "activity": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.39", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.63", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.73", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.4", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] } ] }, { "uniprot_ac": "A0AAA9TKC4", "gene_name": "KYAT1", "activity": [ { "ec_number": "2.6.1.64", "activity": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "2.6.1.64", "activity": "", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "4.4.1.13", "activity": "", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] } ] }, { "uniprot_ac": "A0AAF6YGX9", "gene_name": "", "activity": [ { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.63", "activity": "", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "4.4.1.13", "activity": "", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] } ] }, { "uniprot_ac": "Q0P5G4", "gene_name": "KYAT3", "activity": [ { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] }, { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] } ] }, { "uniprot_ac": "Q5E9N4", "gene_name": "AADAT", "activity": [ { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.39", "activity": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.4", "activity": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.73", "activity": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" }, { "id": "PS51715", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51715" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GB1/RHD3-type G", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 276, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.4.1.13", "ec_name": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "4.4.1.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13" }, { "id": "4.4.1.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.13" } ] }, { "ec_number": "2.6.1.63", "ec_name": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "2.6.1.63", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63" } ] }, { "ec_number": "2.6.1.7", "ec_name": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "2.6.1.7", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7" }, { "id": "2.6.1.7", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.7" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YLU2-1", "uniprot_ac": "A0AAF6YLU2", "uniprot_id": "A0AAF6YLU2_BOVIN", "mass": { "chemical_mass": 137757.0, "monoisotopic_mass": 137757.0 }, "refseq": { "ac": "XP_024841539", "name": "rho GTPase-activating protein 29 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841539" }, "gene_names": [ { "name": "ARHGAP29", "type": "recommended", "evidence": [ { "id": "A0AAF6YLU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ] }, { "name": "ARHGAP29", "type": "synonym", "evidence": [ { "id": "XP_024841539", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841539" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 29", "type": "recommended", "evidence": [ { "id": "A0AAF6YLU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2/entry#names_and_taxonomy" } ] }, { "name": "Rho-type GTPase-activating protein 29", "type": "synonym", "evidence": [ { "id": "A0AAF6YLU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2/entry#names_and_taxonomy" } ] }, { "name": "rho GTPase-activating protein 29 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024841539", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841539" } ] } ], "function": [ { "annotation": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2#function" }, { "database": "UniProtKB", "id": "ARBA00055091", "url": "https://www.uniprot.org/uniprotkb/ARBA00055091#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP29", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2", "locus": { "chromosome": "3", "start_pos": 49319822, "end_pos": 49238420, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004190", "url": "https://www.ensembl.org/id/ENSBTAG00000004190" } ] } } ], "crossref": [ { "id": "A0AAF6YLU2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YLU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20816", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20816", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504657", "url": "https://www.ncbi.nlm.nih.gov/gene/504657", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15228:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15228:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22699", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22699", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841539", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841539", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIAYKQKKTKKKRVLSTGQLSTDVTTSEMGLKSINSNAILDPDYIKELVNDIRKFSHMLLYLKEAILSAVNFTEVNEENKNDLFREVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSQESKSFESVSVESVDSSNEKGSFSPIELDSMLLKNTNSVELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRTNIGLQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSSGLVKNLNRQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILTQLRKLVFQCDLTLKAVTVNLFQMQQLQAASLSSNLQSLCDSAKLYDPGQEYSEFVRATNSAEEEKVDGNVNKQLSSPPISGYGPSDSLEDVVRLPDSSNKMEEDRCSNSADITGPSFLRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFHGVECEECLLVCHRKCLENLVIICGHQKLMGKIHLFGAEFTQVAKKEPDGIPFVLKMCASEIENRALSLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAVEIQHVNEEQEMKKDNPEDKKWPSSSIEISRILLKSKDLLRQLPASNFNSLHYLIVHLKRVVDHSEENKMNSRNLGVIFGPSLLRPRPTTAPITISSLADYSNQARLVEFLITYSQKIFDGSLQPQDSAVGSAGGIAPQVDPGYLPKSLLSPEERDPERSMKSLFFSSKEDIQTTDSECKSFESTPSFEESERKQNALEKCDAYLIDNKGRLLVDQELESASRKTEDACKTSKLPTLKSDREINGVERHLPRTRIRPVSLPIDRLLLLASSPTERNGRNMGNVNSDKLCKNPVFEGVNRKDSPTVVCSKFDGFDQQTLQKTREKQYEQNDHTAKTGMIVPSAFQERGVALNIRSSGDHPVSITQPSKPYTEPVRSTRQVSERRSSDSCPPASVRTPRTLQPQHWTTFYKPPAPAASGRGDEEKPVTPSVAVPPGTTHAPQEHVLKSVPGSENASAGPVHPVSRPEEKAEERDQPDVPTACQRPRLKRMQQFEDLEDEIPQFV", "length": 1224, "header": "tr|A0AAF6YLU2-1|A0AAF6YLU2_BOVIN Isoform 1 of Rho GTPase-activating protein 29 OS=Bos taurus OX=9913 GN=ARHGAP29 PE=4 SV=1 CANONICAL=A0AAF6YLU2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YLU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2/entry", "sequence": { "sequence": "MIAYKQKKTKKKRVLSTGQLSTDVTTSEMGLKSINSNAILDPDYIKELVNDIRKFSHMLLYLKEAILSAVNFTEVNEENKNDLFREVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSQESKSFESVSVESVDSSNEKGSFSPIELDSMLLKNTNSVELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRTNIGLQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSSGLVKNLNRQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILTQLRKLVFQCDLTLKAVTVNLFQMQQLQAASLSSNLQSLCDSAKLYDPGQEYSEFVRATNSAEEEKVDGNVNKQLSSPPISGYGPSDSLEDVVRLPDSSNKMEEDRCSNSADITGPSFLRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFHGVECEECLLVCHRKCLENLVIICGHQKLMGKIHLFGAEFTQVAKKEPDGIPFVLKMCASEIENRALSLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAVEIQHVNEEQEMKKDNPEDKKWPSSSIEISRILLKSKDLLRQLPASNFNSLHYLIVHLKRVVDHSEENKMNSRNLGVIFGPSLLRPRPTTAPITISSLADYSNQARLVEFLITYSQKIFDGSLQPQDSAVGSAGGIAPQVDPGYLPKSLLSPEERDPERSMKSLFFSSKEDIQTTDSECKSFESTPSFEESERKQNALEKCDAYLIDNKGRLLVDQELESASRKTEDACKTSKLPTLKSDREINGVERHLPRTRIRPVSLPIDRLLLLASSPTERNGRNMGNVNSDKLCKNPVFEGVNRKDSPTVVCSKFDGFDQQTLQKTREKQYEQNDHTAKTGMIVPSAFQERGVALNIRSSGDHPVSITQPSKPYTEPVRSTRQVSERRSSDSCPPASVRTPRTLQPQHWTTFYKPPAPAASGRGDEEKPVTPSVAVPPGTTHAPQEHVLKSVPGSENASAGPVHPVSRPEEKAEERDQPDVPTACQRPRLKRMQQFEDLEDEIPQFV", "length": 1224, "header": "tr|A0AAF6YLU2-1|A0AAF6YLU2_BOVIN Isoform 1 of Rho GTPase-activating protein 29 OS=Bos taurus OX=9913 GN=ARHGAP29 PE=4 SV=1 CANONICAL=A0AAF6YLU2-1" }, "locus": { "chromosome": "3", "start_pos": 49319567, "end_pos": 49256674, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005488.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005488.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005488.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005488.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 907, "start_aa": "Thr", "end_pos": 907, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr907", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" }, { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" }, { "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1174, "end_pos": 1176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YLU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" }, { "id": "PS51741", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51741" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-BAR", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 417, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YLU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" }, { "id": "PS50081", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50081" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phorbol-ester/DAG-type", "eco_id": "ECO_0000259", "start_pos": 567, "end_pos": 612, "start_aa": "Thr", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YLU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU2" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 626, "end_pos": 841, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 907 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 1174, "end_pos": 1176 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZ47-1", "uniprot_ac": "A0AAF6YZ47", "uniprot_id": "A0AAF6YZ47_BOVIN", "mass": { "chemical_mass": 16082.0, "monoisotopic_mass": 16082.0 }, "refseq": {}, "gene_names": [ { "name": "CENPS", "type": "recommended", "evidence": [ { "id": "A0AAF6YZ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ] } ], "protein_names": [ { "name": "Centromere protein S", "type": "recommended", "evidence": [ { "id": "A0AAF6YZ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47/entry#names_and_taxonomy" } ] }, { "name": "FANCM-interacting histone fold protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YZ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPS", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47", "locus": { "chromosome": "16", "start_pos": 43133848, "end_pos": 43148824, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013531", "url": "https://www.ensembl.org/id/ENSBTAG00000013531" } ] } } ], "crossref": [ { "id": "A0AAF6YZ47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZ47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013531", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013531", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22919", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22919", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTH0", "url": "https://www.orthodb.org/?gene=A0A3Q1MTH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22980", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22980", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22980:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22980:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15630", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15630", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MTH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZ47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEEEEWSEEQQRFSYLQRLKAAVHYTVGCLCEEVASDKDMQFSKQTIAAISEVTFGQCENFAKDLEMFARHAKRSTINTEDVKLLARRSHSLLKYITEKNEDIAQLNLEKKAKKKKKLEDENRNSVESAEAGVEESEN", "length": 139, "header": "tr|A0AAF6YZ47-1|A0AAF6YZ47_BOVIN Isoform 1 of Centromere protein S OS=Bos taurus OX=9913 GN=CENPS PE=3 SV=1 CANONICAL=A0AAF6YZ47-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTH0/entry", "sequence": { "sequence": "MMEEEEWSEEQQRFSYLQRLKAAVHYTVGCLCEEVASDKDMQFSKQTIAAISEVTFGQCENFAKDLEMFARHAKRSTINTEDVKLLARRSHSLLKYITEKNEDIAQLNLEKKAKKKKKLEDENRNSVESAEAGVEES", "length": 137, "header": "tr|A0A3Q1MTH0-1|A0AAF6YZ47_BOVIN Computationally mapped isoform of Centromere protein S OS=Bos taurus OX=9913 GN=CENPS PE=3 SV=2 CANONICAL=A0AAF6YZ47-1" }, "locus": { "chromosome": "16", "start_pos": 43148784, "end_pos": 43134110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070410.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070410.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057943.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057943.2" } ] } }, { "isoform_ac": "A0AAF6YZ47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47/entry", "sequence": { "sequence": "MMEEEEWSEEQQRFSYLQRLKAAVHYTVGCLCEEVASDKDMQFSKQTIAAISEVTFGQCENFAKDLEMFARHAKRSTINTEDVKLLARRSHSLLKYITEKNEDIAQLNLEKKAKKKKKLEDENRNSVESAEAGVEESEN", "length": 139, "header": "tr|A0AAF6YZ47-1|A0AAF6YZ47_BOVIN Isoform 1 of Centromere protein S OS=Bos taurus OX=9913 GN=CENPS PE=3 SV=1 CANONICAL=A0AAF6YZ47-1" }, "locus": { "chromosome": "16", "start_pos": 43148784, "end_pos": 43134463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017996.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017996.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017996.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017996.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "FANCM-MHF complex", "id": "GO:0071821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZ47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZ47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM24-1", "uniprot_ac": "A0AAF6DM24", "uniprot_id": "A0AAF6DM24_BOVIN", "mass": { "chemical_mass": 66319.0, "monoisotopic_mass": 66319.0 }, "refseq": {}, "gene_names": [ { "name": "GRSF1", "type": "recommended", "evidence": [ { "id": "A0AAF6DM24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ] } ], "protein_names": [ { "name": "G-rich sequence factor 1", "type": "recommended", "evidence": [ { "id": "A0AAF6DM24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TYC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC9#function" }, { "database": "UniProtKB", "id": "ARBA00060139", "url": "https://www.uniprot.org/uniprotkb/ARBA00060139#function" }, { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRSF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24", "locus": { "chromosome": "6", "start_pos": 86196005, "end_pos": 86250072, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008577", "url": "https://www.ensembl.org/id/ENSBTAG00000008577" } ] } } ], "crossref": [ { "id": "A0AAF6DM24", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM24", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12505", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12505", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12730", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12730", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12733", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12733", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13976", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13976", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TYC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELPAEFCPLSGALALHLTRREKPPGVGRLQRAILSEPEVLFSPQFPQSERTAGGSYRSPAPPYPRAATPRGRRPGGAASSPPPPPDSPLPPVPAAHVPGHPSPALDSTSSPLALPPQPPSGPAPPPESMAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSTAGSFPSGVSGRRRLLLLLGAAAAAASQTRGFQSGPVTAGRLAGPPTAAASAAAAAAAASYPALRAPLLPQSLAAAAAGPARGYSQESKTTYLEDLPPLPEYELPPSKLGEEVDDVYLIRAQGLPWSCTVEDVLSFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLHVKSAPMVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMASQALLKHREEIGNRYIEIFPSRRNEVRTHVGSHKGKKIASSPTAKYITEPEMVFEEHEVNEDIRPMTAFESEKEIELPKEMSEKIPEAVDFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFDTHEDAVAAMLKDRSHVHHRYIELFLNSCPKGK", "length": 610, "header": "tr|A0AAF6DM24-1|A0AAF6DM24_BOVIN Isoform 1 of G-rich sequence factor 1 OS=Bos taurus OX=9913 GN=GRSF1 PE=4 SV=1 CANONICAL=A0AAF6DM24-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TYC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC9/entry", "sequence": { "sequence": "MDLSVSVISGALALHLTRREKPPGVGRLQRAILSEPEVLFSPQFPQSERTAGGSYRSPAPPYPRAATPRGRRPGGAASSPPPPPDSPLPPVPAAHVPGHPSPALDSTSSPLALPPQPPSGPAPPPESMAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSTAGSFPSGVSGRRRLLLLLGAAAAAASQTRGFQSGPVTAGRLAGPPTAAASAAAAAAAASYPALRAPLLPQSLAAAAAGPARGYSQESKTTYLEDLPPLPEYELPPSKLGEEVDDVYLIRAQGLPWSCTVEDVLSFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLHVKSAPMVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMASQALLKHREEIGNRYIEIFPSRRNEVRTHVGSHKGKKIASSPTAKYITEPEMVFEEHEVNEDIRPMTAFESEKEIELPKEMSEKIPEAVDFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFDTHEDAVAAMLKDRSHVHHRYIELFLNSCPKGK", "length": 608, "header": "tr|A0AAA9TYC9-1|A0AAF6DM24_BOVIN Computationally mapped isoform of G-rich sequence factor 1 OS=Bos taurus OX=9913 GN=GRSF1 PE=4 SV=1 CANONICAL=A0AAF6DM24-1" }, "locus": { "chromosome": "6", "start_pos": 86215851, "end_pos": 86202045, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125886.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125886.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103358.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103358.1" } ] } }, { "isoform_ac": "A0AAF6DM24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24/entry", "sequence": { "sequence": "MELPAEFCPLSGALALHLTRREKPPGVGRLQRAILSEPEVLFSPQFPQSERTAGGSYRSPAPPYPRAATPRGRRPGGAASSPPPPPDSPLPPVPAAHVPGHPSPALDSTSSPLALPPQPPSGPAPPPESMAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSTAGSFPSGVSGRRRLLLLLGAAAAAASQTRGFQSGPVTAGRLAGPPTAAASAAAAAAAASYPALRAPLLPQSLAAAAAGPARGYSQESKTTYLEDLPPLPEYELPPSKLGEEVDDVYLIRAQGLPWSCTVEDVLSFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLHVKSAPMVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMASQALLKHREEIGNRYIEIFPSRRNEVRTHVGSHKGKKIASSPTAKYITEPEMVFEEHEVNEDIRPMTAFESEKEIELPKEMSEKIPEAVDFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFDTHEDAVAAMLKDRSHVHHRYIELFLNSCPKGK", "length": 610, "header": "tr|A0AAF6DM24-1|A0AAF6DM24_BOVIN Isoform 1 of G-rich sequence factor 1 OS=Bos taurus OX=9913 GN=GRSF1 PE=4 SV=1 CANONICAL=A0AAF6DM24-1" }, "locus": { "chromosome": "6", "start_pos": 86249873, "end_pos": 86202045, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011313.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011313.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011313.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011313.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 210, "start_aa": "Thr", "end_pos": 210, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr210", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" }, { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial RNA catabolic process", "id": "GO:0000962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000962", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM24" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 280, "end_pos": 376, "start_aa": "Tyr", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 210 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DME4-1", "uniprot_ac": "A0AAF6DME4", "uniprot_id": "A0AAF6DME4_BOVIN", "mass": { "chemical_mass": 75100.0, "monoisotopic_mass": 75100.0 }, "refseq": {}, "gene_names": [ { "name": "NPEPL1", "type": "recommended", "evidence": [ { "id": "A0AAF6DME4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" } ] } ], "protein_names": [ { "name": "Probable aminopeptidase NPEPL1", "type": "recommended", "evidence": [ { "id": "A0AAF6DME4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4/entry#names_and_taxonomy" } ] }, { "name": "Aminopeptidase-like 1", "type": "synonym", "evidence": [ { "id": "A0AAF6DME4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9U090", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U090#function" }, { "database": "UniProtKB", "id": "ARBA00059069", "url": "https://www.uniprot.org/uniprotkb/ARBA00059069#function" }, { "database": "UniProtKB", "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPEPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4", "locus": { "chromosome": "13", "start_pos": 57666166, "end_pos": 57682867, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016724", "url": "https://www.ensembl.org/id/ENSBTAG00000016724" } ] } } ], "crossref": [ { "id": "A0AAF6DME4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DME4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00433", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00433", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11963", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11963", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11963:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11963:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00883", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00883", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18295", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18295", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9U090", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U090", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U090-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U090-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DME4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANVGLQFQASAGDADPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPSRVSRHNSPSAAHFITRLVRTCLPPGTHRCILMVCERSDAFASACALARAFPLFTHRSGASRRTEKKTVTVEFFLVGQDNGPVEVSTLQCLTSATEGVRLAARIVDTPCNEMNTDTFLEEIKKVGKELGIVPTVIRDEELKARGFGGIYGVGKAAIHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSMKGKTTMPGMKRDCGGAAAVLGAFRAAVKQGFKDTLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDVATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRQCGDLVHPLVYCPELHFSEFTSAVADMKNSVAVGPGQQPQLLRWPLHRLTHRLRLAWGLGPPGYRRARARRRARHGLRCGPSAGTLRPGLRGPSAEPGIPTWLRGGRPGGGRGEGLQEAQACVTQPPCPVTLGTLPHFALINSKQLEDYTLRCFVFSCHGDGNSSFLCLRRQLRVRGAQGGVSGQHWVCFMFDSPPASADHAPLWGPCTTPRLQNACTALMLLSTWPSRPPPVPGPHGGCRWPHLQPQAPYMAPTLQGTQAPLQLGQSLPPTDHPFERMGRLGSGFMEQKECLLGPL", "length": 699, "header": "tr|A0AAF6DME4-1|A0AAF6DME4_BOVIN Isoform 1 of Probable aminopeptidase NPEPL1 OS=Bos taurus OX=9913 GN=NPEPL1 PE=3 SV=1 CANONICAL=A0AAF6DME4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U090-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U090/entry", "sequence": { "sequence": "MANVGLQFQASAGDADPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPSRVSRHNSPSAAHFITRLVRTCLPPGTHRCILMVCERSDAFASACALARAFPLFTHRSGASRRTEKKTVTVEFFLVGQDNGPVEVSTLQCLTSATEGVRLAARIVDTPCNEMNTDTFLEEIKKVGKELGIVPTVIRDEELKARGFGGIYGVGKAAIHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSMKGKLQFYQVMPAVLETTMPGMKRDCGGAAAVLGAFRAAVKQGFKDTLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDVATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRQCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIASHIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGQASEDPLLNLVSPLGCEVDAQEGDAERDSKRRRLV", "length": 535, "header": "tr|A0AAA9U090-1|A0AAF6DME4_BOVIN Computationally mapped isoform of Probable aminopeptidase NPEPL1 OS=Bos taurus OX=9913 GN=NPEPL1 PE=3 SV=1 CANONICAL=A0AAF6DME4-1" }, "locus": { "chromosome": "13", "start_pos": 57682813, "end_pos": 57666732, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119034.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119034.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103304.1" } ] } }, { "isoform_ac": "A0AAF6DME4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4/entry", "sequence": { "sequence": "MANVGLQFQASAGDADPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPSRVSRHNSPSAAHFITRLVRTCLPPGTHRCILMVCERSDAFASACALARAFPLFTHRSGASRRTEKKTVTVEFFLVGQDNGPVEVSTLQCLTSATEGVRLAARIVDTPCNEMNTDTFLEEIKKVGKELGIVPTVIRDEELKARGFGGIYGVGKAAIHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSMKGKTTMPGMKRDCGGAAAVLGAFRAAVKQGFKDTLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDVATLTGAQGIATGKYHAAVLTNSAEWEAACVKAGRQCGDLVHPLVYCPELHFSEFTSAVADMKNSVAVGPGQQPQLLRWPLHRLTHRLRLAWGLGPPGYRRARARRRARHGLRCGPSAGTLRPGLRGPSAEPGIPTWLRGGRPGGGRGEGLQEAQACVTQPPCPVTLGTLPHFALINSKQLEDYTLRCFVFSCHGDGNSSFLCLRRQLRVRGAQGGVSGQHWVCFMFDSPPASADHAPLWGPCTTPRLQNACTALMLLSTWPSRPPPVPGPHGGCRWPHLQPQAPYMAPTLQGTQAPLQLGQSLPPTDHPFERMGRLGSGFMEQKECLLGPL", "length": 699, "header": "tr|A0AAF6DME4-1|A0AAF6DME4_BOVIN Isoform 1 of Probable aminopeptidase NPEPL1 OS=Bos taurus OX=9913 GN=NPEPL1 PE=3 SV=1 CANONICAL=A0AAF6DME4-1" }, "locus": { "chromosome": "13", "start_pos": 57682813, "end_pos": 57666208, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022232.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022232.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022232.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022232.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" } ], "pmid": "" }, { "name": "metalloaminopeptidase activity", "id": "GO:0070006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070006", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DME4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DME4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME4" }, { "id": "PS00631", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00631" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cytosol aminopeptidase", "eco_id": "ECO_0000259", "start_pos": 340, "end_pos": 347, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 320, "end_pos": 322 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 565, "end_pos": 567 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJX1-1", "uniprot_ac": "A0AAF6YJX1", "uniprot_id": "A0AAF6YJX1_BOVIN", "mass": { "chemical_mass": 107037.0, "monoisotopic_mass": 107037.0 }, "refseq": {}, "gene_names": [ { "name": "MSH2", "type": "recommended", "evidence": [ { "id": "A0AAF6YJX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ] } ], "protein_names": [ { "name": "DNA mismatch repair protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YJX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the post-replicative DNA mismatch repair system (MMR).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9U0Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z2#function" }, { "database": "UniProtKB", "id": "RU003756", "url": "https://www.uniprot.org/uniprotkb/RU003756#function" }, { "database": "UniProtKB", "id": "PIRNR005813", "url": "https://www.uniprot.org/uniprotkb/PIRNR005813#function" }, { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MSH2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1", "locus": { "chromosome": "11", "start_pos": 29901146, "end_pos": 29804982, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002742", "url": "https://www.ensembl.org/id/ENSBTAG00000002742" } ] } } ], "crossref": [ { "id": "A0AAF6YJX1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03285", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03285", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000432", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000432", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00488", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00488", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01624", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01624", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9U0Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVQPKDTLQLDSAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHREDALLAAREVFKTQGVVKYMGPAGAKTLESVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAFKASPGNLSQFEDILFGNNDMSASIGVVGVKMSTVDGQRQVGVGYVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECVMPGGETAGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLLKGKKGEQVNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTSGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQNLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKYEGKHQALFLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMDDLEKKMQSTLVSAARDLGLDPGKQIKLDSSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQNAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSDAAPVPYVRPVILEKGRGRITLKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVVVLMAQIGCFVPCEWAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILSCHEESSHMRDQTCVPCIARSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQNIGKPQECDEMEPAAKRCYLEREQGEKIIQEFLSKVKQVPFTEMSEESITRKLKQLKAEVIAKNNSFVNEIISRIKVTA", "length": 953, "header": "tr|A0AAF6YJX1-1|A0AAF6YJX1_BOVIN Isoform 1 of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH2 PE=3 SV=1 CANONICAL=A0AAF6YJX1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U0Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z2/entry", "sequence": { "sequence": "MAVQPKDTLQLDSAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHREDALLAAREVFKTQGVVKYMGPAGAKTLESVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAFKASPGNLSQFEDILFGNNDMSASIGVVGVKMSTVDGQRQVGVGYVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECVMPGGETAGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLLKGKKGEQVNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTSGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQNLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKYEGKHQALFLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMDDLEKKMQSTLVSAARDLGLDPGKQIKLDSSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQNAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSDAAPVPYVRPVILEKGRGRITLKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVVVLMAQIGCFVPCEWAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQNIGKPQECDEMEPAAKRCYLEREQGEKIIQEFLSKVKQVPFTEMSEESITRKLKQLKAEVIAKNNSFVNEIISRIKIRESRPIPAYTKRVI", "length": 946, "header": "tr|A0AAA9U0Z2-1|A0AAF6YJX1_BOVIN Computationally mapped isoform of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH2 PE=3 SV=1 CANONICAL=A0AAF6YJX1-1" }, "locus": { "chromosome": "11", "start_pos": 29900509, "end_pos": 29805038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093038.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093038.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102809.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102809.1" } ] } }, { "isoform_ac": "A0AAF6YJX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1/entry", "sequence": { "sequence": "MAVQPKDTLQLDSAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHREDALLAAREVFKTQGVVKYMGPAGAKTLESVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAFKASPGNLSQFEDILFGNNDMSASIGVVGVKMSTVDGQRQVGVGYVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECVMPGGETAGDMGKLRQVIQRGGILITERKRADFSTKDIYQDLNRLLKGKKGEQVNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTSGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQNLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKYEGKHQALFLAVFVTPLIDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMDDLEKKMQSTLVSAARDLGLDPGKQIKLDSSTQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQNAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSDAAPVPYVRPVILEKGRGRITLKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQTGVVVLMAQIGCFVPCEWAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILSCHEESSHMRDQTCVPCIARSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQNIGKPQECDEMEPAAKRCYLEREQGEKIIQEFLSKVKQVPFTEMSEESITRKLKQLKAEVIAKNNSFVNEIISRIKVTA", "length": 953, "header": "tr|A0AAF6YJX1-1|A0AAF6YJX1_BOVIN Isoform 1 of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH2 PE=3 SV=1 CANONICAL=A0AAF6YJX1-1" }, "locus": { "chromosome": "11", "start_pos": 29885984, "end_pos": 29805038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003556.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003556.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003556.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003556.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "MutSalpha complex", "id": "GO:0032301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "MutSbeta complex", "id": "GO:0032302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032302", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 18, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "mismatched DNA binding", "id": "GO:0030983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030983", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "ATP-dependent DNA damage sensor activity", "id": "GO:0140664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140664", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "oxidized purine DNA binding", "id": "GO:0032357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032357", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "single guanine insertion binding", "id": "GO:0032142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032142", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "single thymine insertion binding", "id": "GO:0032143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032143", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "dinucleotide repeat insertion binding", "id": "GO:0032181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032181", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "ADP binding", "id": "GO:0043531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043531", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "centromeric DNA binding", "id": "GO:0019237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019237", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "MutLalpha complex binding", "id": "GO:0032405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032405", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "guanine/thymine mispair binding", "id": "GO:0032137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032137", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "mismatch repair", "id": "GO:0006298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "positive regulation of isotype switching to IgG isotypes", "id": "GO:0048304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048304", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "negative regulation of DNA recombination", "id": "GO:0045910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045910", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "maintenance of DNA repeat elements", "id": "GO:0043570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043570", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "DNA damage tolerance", "id": "GO:0006301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" }, { "name": "positive regulation of isotype switching to IgA isotypes", "id": "GO:0048298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048298", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 538, "end_pos": 540, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 938, "end_pos": 940, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YJX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJX1" }, { "id": "PS00486", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00486" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA mismatch repair proteins mutS family", "eco_id": "ECO_0000259", "start_pos": 762, "end_pos": 778, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 477, "end_pos": 479 }, { "start_pos": 538, "end_pos": 540 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 938, "end_pos": 940 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLT3-1", "uniprot_ac": "A0AAF6DLT3", "uniprot_id": "A0AAF6DLT3_BOVIN", "mass": { "chemical_mass": 46035.0, "monoisotopic_mass": 46035.0 }, "refseq": {}, "gene_names": [ { "name": "SERPINI2", "type": "recommended", "evidence": [ { "id": "A0AAF6DLT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3" } ] } ], "protein_names": [ { "name": "Serpin family I member 2", "type": "synonym", "evidence": [ { "id": "A0AAF6DLT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLT3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINI2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3", "locus": { "chromosome": "1", "start_pos": 100031888, "end_pos": 99995832, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011423", "url": "https://www.ensembl.org/id/ENSBTAG00000011423" } ] } } ], "crossref": [ { "id": "A0AAF6DLT3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19576", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19576", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DLT3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDKILLWSLLLTFSGSQASSPWAQRNAEFVVDLYQAVGLSHKNNIIISPLGTTLALGMVQLGAKGKAQQQIRKTLKFQDTSTGEEFSELKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQNAKACAETISNWVESKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFNKEDTQLMNFTLKDGTAVKIPMMKALLRTKYGYFSESSINYQVLELPYKGDEFSLIIILPAEHTNIEEMEKLITAPQILQWFSEMQEQEVEISLPSRFKVEQKLDFKEALYSLNITEIFSGGCDLSGITDSSEVYVSRVMQQVFFEINEEGSEVATSTGINTPVIMSLSRNQFIANHPFLFIMKNNPTDSILLMGRVTNPDTQRMKGRDLDSL", "length": 406, "header": "tr|A0AAF6DLT3-1|A0AAF6DLT3_BOVIN Isoform 1 of Serpin family I member 2 OS=Bos taurus OX=9913 GN=SERPINI2 PE=3 SV=1 CANONICAL=A0AAF6DLT3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DLT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3/entry", "sequence": { "sequence": "MDKILLWSLLLTFSGSQASSPWAQRNAEFVVDLYQAVGLSHKNNIIISPLGTTLALGMVQLGAKGKAQQQIRKTLKFQDTSTGEEFSELKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQNAKACAETISNWVESKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFNKEDTQLMNFTLKDGTAVKIPMMKALLRTKYGYFSESSINYQVLELPYKGDEFSLIIILPAEHTNIEEMEKLITAPQILQWFSEMQEQEVEISLPSRFKVEQKLDFKEALYSLNITEIFSGGCDLSGITDSSEVYVSRVMQQVFFEINEEGSEVATSTGINTPVIMSLSRNQFIANHPFLFIMKNNPTDSILLMGRVTNPDTQRMKGRDLDSL", "length": 406, "header": "tr|A0AAF6DLT3-1|A0AAF6DLT3_BOVIN Isoform 1 of Serpin family I member 2 OS=Bos taurus OX=9913 GN=SERPINI2 PE=3 SV=1 CANONICAL=A0AAF6DLT3-1" }, "locus": { "chromosome": "1", "start_pos": 100031739, "end_pos": 99998256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015176.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015176.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015176.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015176.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLT3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLT3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT3" }, { "id": "SM00093", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serpin", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 393, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 }, { "start_pos": 307, "end_pos": 309 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLT8-1", "uniprot_ac": "A0AAF6DLT8", "uniprot_id": "A0AAF6DLT8_BOVIN", "mass": { "chemical_mass": 16311.0, "monoisotopic_mass": 16311.0 }, "refseq": {}, "gene_names": [ { "name": "UBALD1", "type": "recommended", "evidence": [ { "id": "A0AAF6DLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8" } ] } ], "protein_names": [ { "name": "UBA like domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAF6DLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBALD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8", "locus": { "chromosome": "25", "start_pos": 3744238, "end_pos": 3749423, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026394", "url": "https://www.ensembl.org/id/ENSBTAG00000026394" } ] } } ], "crossref": [ { "id": "A0AAF6DLT8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31993", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31993", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31993:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31993:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DLT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVNMDELKHQVMINQFVLTAGCAADQAKQLLQAAHWQFETALSAFFQETNIPYSHHHHQMASESFHSGGSGSPMAATATSPPPHFPLTATGSFAAPSWPAAASPPGGAQHHQPPQPPLWTPAPTSPASDWPPLAPQQATSEPRAHPAMEAER", "length": 153, "header": "tr|A0AAF6DLT8-1|A0AAF6DLT8_BOVIN Isoform 1 of UBA like domain containing 1 OS=Bos taurus OX=9913 GN=UBALD1 PE=3 SV=1 CANONICAL=A0AAF6DLT8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DLT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8/entry", "sequence": { "sequence": "MSVNMDELKHQVMINQFVLTAGCAADQAKQLLQAAHWQFETALSAFFQETNIPYSHHHHQMASESFHSGGSGSPMAATATSPPPHFPLTATGSFAAPSWPAAASPPGGAQHHQPPQPPLWTPAPTSPASDWPPLAPQQATSEPRAHPAMEAER", "length": 153, "header": "tr|A0AAF6DLT8-1|A0AAF6DLT8_BOVIN Isoform 1 of UBA like domain containing 1 OS=Bos taurus OX=9913 GN=UBALD1 PE=3 SV=1 CANONICAL=A0AAF6DLT8-1" }, "locus": { "chromosome": "25", "start_pos": 3749342, "end_pos": 3745242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056899.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056899.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052451.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052451.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT8" }, { "id": "PF22566", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22566" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA-like", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 53, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLV6-1", "uniprot_ac": "A0AAF6DLV6", "uniprot_id": "A0AAF6DLV6_BOVIN", "mass": { "chemical_mass": 32453.0, "monoisotopic_mass": 32453.0 }, "refseq": {}, "gene_names": [ { "name": "CEACAM19", "type": "recommended", "evidence": [ { "id": "A0AAF6DLV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6" } ] } ], "protein_names": [ { "name": "CEA cell adhesion molecule 19", "type": "synonym", "evidence": [ { "id": "A0AAF6DLV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLV6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEACAM19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6", "locus": { "chromosome": "18", "start_pos": 52465524, "end_pos": 52446717, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015313", "url": "https://www.ensembl.org/id/ENSBTAG00000015313" } ] } } ], "crossref": [ { "id": "A0AAF6DLV6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44427:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44427:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DLV6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLNNYSERFRGSQPQDTKMEIPAGSQHAFPKSLLLSASILALWVPQGSWAALRIQKIPEQPQMNQDLLLSVQGIPNTFQDFSWYLGEEANGGTMLFTYIPKLLRPQRDGSAMHQRDIVGFSNGSMLLRHAQPSDSGTYQVAVTINPSWTMRAKTEVQVVEKPKELPVTNPPVSAGIVAAIVIGSLATGCMSVGIIAYLLVTRGWRAQNHRITATEKPELGPSHRAGDDSIYEAIPSPVLLVSPCDTGPMNTATPPDLPLPPPPPPPPPPPVPQPENHPYQDLLNPDPAPYCQLVPTP", "length": 298, "header": "tr|A0AAF6DLV6-1|A0AAF6DLV6_BOVIN Isoform 1 of CEA cell adhesion molecule 19 OS=Bos taurus OX=9913 GN=CEACAM19 PE=3 SV=1 CANONICAL=A0AAF6DLV6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DLV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6/entry", "sequence": { "sequence": "MFLNNYSERFRGSQPQDTKMEIPAGSQHAFPKSLLLSASILALWVPQGSWAALRIQKIPEQPQMNQDLLLSVQGIPNTFQDFSWYLGEEANGGTMLFTYIPKLLRPQRDGSAMHQRDIVGFSNGSMLLRHAQPSDSGTYQVAVTINPSWTMRAKTEVQVVEKPKELPVTNPPVSAGIVAAIVIGSLATGCMSVGIIAYLLVTRGWRAQNHRITATEKPELGPSHRAGDDSIYEAIPSPVLLVSPCDTGPMNTATPPDLPLPPPPPPPPPPPVPQPENHPYQDLLNPDPAPYCQLVPTP", "length": 298, "header": "tr|A0AAF6DLV6-1|A0AAF6DLV6_BOVIN Isoform 1 of CEA cell adhesion molecule 19 OS=Bos taurus OX=9913 GN=CEACAM19 PE=3 SV=1 CANONICAL=A0AAF6DLV6-1" }, "locus": { "chromosome": "18", "start_pos": 52464776, "end_pos": 52446747, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020358.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020358.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020358.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020358.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV6" }, { "id": "PF07686", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin V-set", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 159, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLX7-1", "uniprot_ac": "A0AAF6DLX7", "uniprot_id": "A0AAF6DLX7_BOVIN", "mass": { "chemical_mass": 33885.0, "monoisotopic_mass": 33885.0 }, "refseq": {}, "gene_names": [ { "name": "MAPRE3", "type": "recommended", "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ] } ], "protein_names": [ { "name": "Microtubule-associated protein RP/EB family member 3", "type": "recommended", "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7/entry#names_and_taxonomy" } ] }, { "name": "EB1 protein family member 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7/entry#names_and_taxonomy" } ] }, { "name": "End-binding protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7/entry#names_and_taxonomy" } ] }, { "name": "RP3", "type": "synonym", "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7#function" }, { "database": "UniProtKB", "id": "ARBA00055374", "url": "https://www.uniprot.org/uniprotkb/ARBA00055374#function" }, { "database": "UniProtKB", "id": "A0ABI0NUT5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUT5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAPRE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7", "locus": { "chromosome": "11", "start_pos": 72609654, "end_pos": 72665036, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008884", "url": "https://www.ensembl.org/id/ENSBTAG00000008884" } ] } } ], "crossref": [ { "id": "A0AAF6DLX7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "528839", "url": "https://www.ncbi.nlm.nih.gov/gene/528839", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10623", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10623", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUT5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUT5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNELWGWDCIPGRSWGMAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHETDAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY", "length": 297, "header": "tr|A0AAF6DLX7-1|A0AAF6DLX7_BOVIN Isoform 1 of Microtubule-associated protein RP/EB family member 3 OS=Bos taurus OX=9913 GN=MAPRE3 PE=3 SV=1 CANONICAL=A0AAF6DLX7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DLX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7/entry", "sequence": { "sequence": "MNELWGWDCIPGRSWGMAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHETDAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY", "length": 297, "header": "tr|A0AAF6DLX7-1|A0AAF6DLX7_BOVIN Isoform 1 of Microtubule-associated protein RP/EB family member 3 OS=Bos taurus OX=9913 GN=MAPRE3 PE=3 SV=1 CANONICAL=A0AAF6DLX7-1" }, "locus": { "chromosome": "11", "start_pos": 72616868, "end_pos": 72610518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011696.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011696.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011696.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011696.5" } ] } }, { "isoform_ac": "A0ABI0NUT5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUT5/entry", "sequence": { "sequence": "MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHETDAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY", "length": 281, "header": "tr|A0ABI0NUT5-1|A0ABI0NUT5_BOVIN Computationally mapped isoform of Microtubule-associated protein RP/EB family member 3 OS=Bos taurus OX=9913 GN=MAPRE3 PE=3 SV=1 CANONICAL=A0AAF6DLX7-1" }, "locus": { "chromosome": "11", "start_pos": 72614457, "end_pos": 72610518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139690.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139690.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104305.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "microtubule plus-end binding", "id": "GO:0051010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051010", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "regulation of microtubule polymerization", "id": "GO:0031113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031113", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "microtubule plus-end", "id": "GO:0035371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035371", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "mitotic spindle astral microtubule end", "id": "GO:1905721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905721", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 132, "start_aa": "Asn", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DLX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX7" }, { "id": "PS51230", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51230" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EB1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 210, "end_pos": 280, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 30, "end_pos": 32 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 47, "end_pos": 49 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLY8-1", "uniprot_ac": "A0AAF6DLY8", "uniprot_id": "A0AAF6DLY8_BOVIN", "mass": { "chemical_mass": 141706.0, "monoisotopic_mass": 141706.0 }, "refseq": { "ac": "XP_024851766", "name": "contactin-associated protein-like 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851766" }, "gene_names": [ { "name": "CNTNAP3", "type": "recommended", "evidence": [ { "id": "A0AAF6DLY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" } ] }, { "name": "CNTNAP3", "type": "synonym", "evidence": [ { "id": "XP_024851766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851766" } ] } ], "protein_names": [ { "name": "Contactin associated protein family member 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DLY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8/entry#names_and_taxonomy" } ] }, { "name": "contactin-associated protein-like 3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024851766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851766" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNTNAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8", "locus": {} } ], "crossref": [ { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784375", "url": "https://www.ncbi.nlm.nih.gov/gene/784375", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15036:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15036:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851766", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851766", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DLY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPVAGTFLRMLFLLSAQPWSTLAAGNTYNCDAPLASSLPRASFTSSSELSSSHGPGFASLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYLLMFSDGGRNWKQYRREESIWGFPGNTNADSVVHYRLQPTFEARFLRFLPLTWNPKGRIGMRIEVYGCAYRSEMVHFDGKSSLLYTFNHKSMNPIKEVISLKFKTRENNGILLHREGPNDKHITLELVKGKLILFLNSGHADLPSPDALMLGSLLDDEHWHSVLIELLSTDVNFTVDTHTHHFRAKGESSYVDLDYKISFGGIPGHGKSVAFPHKNFHGCFENLYYNEVDIIDLSKKHKPQVLIMGNVSFSCSHTQTVPMTFLSSRSYLVLPGISREDKVSVIFQFRTWNRAGLLLTSQFHHRSGALILVLSDGKLKLSLSQPGHPARDITAGAGLNDGQWHSVSLSARGNHLSVMVDGEAASMAHSLRGQIESGDTYYLGGCPDNSSHPGCTNSLGGFQGCLRLISIGDEAVDPISIQQGALGSFRDLQIDTCGLTDRCLPSYCEHGGECSQSWNTFSCDCAHTGYMGATCHSSLYEQSCEAHWHRGNSSGLYYIDSDGSGPLEPSLVYCNMTDTAWTSVQHNGSHLVKIKSLNGESPHPVFFKYIASMDQLQTIIDYADNCQQELTFHCKKSRLSTPQDGTPVSWWVGRTNETHTYWGGSQPDAQKCTCGLEGNCIDSQYYCNCDADRNEWTSNTVVLSHRKHLPVTQIVMRDTGQPHSEAAYSLGPLLCSGDNSFWNSASFNTETSYLHFPTFRGELSADVSFFFKTTASSGVFLENLGITDFIRLELRAPTEVTFSFDVGNGPCEVTVQSPTAFNDNRWHHVKADRNIKEASLQVGQHPRKTQPASADGHARLQLNSQLFVGGTASRQRGFLGCIRSLRLNGLALDLEERAMMTPGVEPGCPGHCSTYGHLCHNGGRCREKRRGITCDCTVSAYDGPFCENDISAYFGAGSSVIYNFQDHYNDTFSKNSSSFAALFHEDLTLTGEMATLSFRTTGTPSLLLYVSSFYEEYLSVILAPNGSLQIRYKLDRHREPDVFNFGFKNLADGQLHHVRINREAAVMFVEVNQNARRQVILSSGTEFNAVKSLMLGTVLEPLGADPDTLRAGARGFTGCLSAVRFGPAVPLKAALRSGGHSQVTVRGHVATASRCADGARPGAPAREATRPLAGGAGVIAVVIFILLCITAIAIRIYQQRWLYQKNETNIPKTGDNAETALKSEINMQCTVNESQKEYFF", "length": 1286, "header": "tr|A0AAF6DLY8-1|A0AAF6DLY8_BOVIN Isoform 1 of Contactin associated protein family member 3 OS=Bos taurus OX=9913 GN=CNTNAP3 PE=3 SV=1 CANONICAL=A0AAF6DLY8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DLY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8/entry", "sequence": { "sequence": "MDPVAGTFLRMLFLLSAQPWSTLAAGNTYNCDAPLASSLPRASFTSSSELSSSHGPGFASLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYLLMFSDGGRNWKQYRREESIWGFPGNTNADSVVHYRLQPTFEARFLRFLPLTWNPKGRIGMRIEVYGCAYRSEMVHFDGKSSLLYTFNHKSMNPIKEVISLKFKTRENNGILLHREGPNDKHITLELVKGKLILFLNSGHADLPSPDALMLGSLLDDEHWHSVLIELLSTDVNFTVDTHTHHFRAKGESSYVDLDYKISFGGIPGHGKSVAFPHKNFHGCFENLYYNEVDIIDLSKKHKPQVLIMGNVSFSCSHTQTVPMTFLSSRSYLVLPGISREDKVSVIFQFRTWNRAGLLLTSQFHHRSGALILVLSDGKLKLSLSQPGHPARDITAGAGLNDGQWHSVSLSARGNHLSVMVDGEAASMAHSLRGQIESGDTYYLGGCPDNSSHPGCTNSLGGFQGCLRLISIGDEAVDPISIQQGALGSFRDLQIDTCGLTDRCLPSYCEHGGECSQSWNTFSCDCAHTGYMGATCHSSLYEQSCEAHWHRGNSSGLYYIDSDGSGPLEPSLVYCNMTDTAWTSVQHNGSHLVKIKSLNGESPHPVFFKYIASMDQLQTIIDYADNCQQELTFHCKKSRLSTPQDGTPVSWWVGRTNETHTYWGGSQPDAQKCTCGLEGNCIDSQYYCNCDADRNEWTSNTVVLSHRKHLPVTQIVMRDTGQPHSEAAYSLGPLLCSGDNSFWNSASFNTETSYLHFPTFRGELSADVSFFFKTTASSGVFLENLGITDFIRLELRAPTEVTFSFDVGNGPCEVTVQSPTAFNDNRWHHVKADRNIKEASLQVGQHPRKTQPASADGHARLQLNSQLFVGGTASRQRGFLGCIRSLRLNGLALDLEERAMMTPGVEPGCPGHCSTYGHLCHNGGRCREKRRGITCDCTVSAYDGPFCENDISAYFGAGSSVIYNFQDHYNDTFSKNSSSFAALFHEDLTLTGEMATLSFRTTGTPSLLLYVSSFYEEYLSVILAPNGSLQIRYKLDRHREPDVFNFGFKNLADGQLHHVRINREAAVMFVEVNQNARRQVILSSGTEFNAVKSLMLGTVLEPLGADPDTLRAGARGFTGCLSAVRFGPAVPLKAALRSGGHSQVTVRGHVATASRCADGARPGAPAREATRPLAGGAGVIAVVIFILLCITAIAIRIYQQRWLYQKNETNIPKTGDNAETALKSEINMQCTVNESQKEYFF", "length": 1286, "header": "tr|A0AAF6DLY8-1|A0AAF6DLY8_BOVIN Isoform 1 of Contactin associated protein family member 3 OS=Bos taurus OX=9913 GN=CNTNAP3 PE=3 SV=1 CANONICAL=A0AAF6DLY8-1" }, "locus": { "chromosome": "8", "start_pos": 66139071, "end_pos": 65904119, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008454.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008454.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008454.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008454.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1015, "end_pos": 1017, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1021, "end_pos": 1023, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1071, "end_pos": 1073, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1252, "end_pos": 1254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1278, "end_pos": 1280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 702, "end_pos": 704, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 545, "end_pos": 582, "start_aa": "Leu", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DLY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" }, { "id": "PS50022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F5/8 type C", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 177, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DLY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" }, { "id": "PS51406", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000259", "start_pos": 581, "end_pos": 632, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DLY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY8" }, { "id": "PS50025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin G", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 361, "start_aa": "Met", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1015, "end_pos": 1017 }, { "start_pos": 1021, "end_pos": 1023 }, { "start_pos": 1071, "end_pos": 1073 }, { "start_pos": 1252, "end_pos": 1254 }, { "start_pos": 1278, "end_pos": 1280 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 621, "end_pos": 623 }, { "start_pos": 633, "end_pos": 635 }, { "start_pos": 702, "end_pos": 704 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DLY9-1", "uniprot_ac": "A0AAF6DLY9", "uniprot_id": "A0AAF6DLY9_BOVIN", "mass": { "chemical_mass": 45818.0, "monoisotopic_mass": 45818.0 }, "refseq": {}, "gene_names": [ { "name": "SAMD14", "type": "recommended", "evidence": [ { "id": "A0AAF6DLY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9" } ] } ], "protein_names": [ { "name": "Sterile alpha motif domain containing 14", "type": "synonym", "evidence": [ { "id": "A0AAF6DLY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DLY9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAMD14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9", "locus": { "chromosome": "19", "start_pos": 36543419, "end_pos": 36526611, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040521", "url": "https://www.ensembl.org/id/ENSBTAG00000040521" } ] } } ], "crossref": [ { "id": "A0AAF6DLY9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DLY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09512", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09512", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16154:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16154:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DLY9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLELSRVMASSKLREPVDEVFDLDLAVPETVRLDSSLHKARAQLLAKGRRHRPSRSRLRDSASSAEDGEGSDGPGGKGTDGCGSPLHRLRSPLHSGPGSPAGGSFCLEPPGLRRSLDEDEPPPSPLARYRPLHNTASHEGLAAASGSPPRSAASSDSSPSFVRRHPRAELHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTSKSRKEKGSNRLSMGSRESVEGSSRSGGSPFLPFSWFTDSGKGSASSGSTTSPSCSPKREGFSPKKSASQESTLSDDSTPPSSSPKIPSGPRQAAKCSYPYHTLSQSSDEFLDEPLPTVYHWTSQQVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKELAAAAEKERKAQEKAARQREKLRRREQEAKKS", "length": 424, "header": "tr|A0AAF6DLY9-1|A0AAF6DLY9_BOVIN Isoform 1 of Sterile alpha motif domain containing 14 OS=Bos taurus OX=9913 GN=SAMD14 PE=4 SV=1 CANONICAL=A0AAF6DLY9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DLY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9/entry", "sequence": { "sequence": "MLELSRVMASSKLREPVDEVFDLDLAVPETVRLDSSLHKARAQLLAKGRRHRPSRSRLRDSASSAEDGEGSDGPGGKGTDGCGSPLHRLRSPLHSGPGSPAGGSFCLEPPGLRRSLDEDEPPPSPLARYRPLHNTASHEGLAAASGSPPRSAASSDSSPSFVRRHPRAELHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTSKSRKEKGSNRLSMGSRESVEGSSRSGGSPFLPFSWFTDSGKGSASSGSTTSPSCSPKREGFSPKKSASQESTLSDDSTPPSSSPKIPSGPRQAAKCSYPYHTLSQSSDEFLDEPLPTVYHWTSQQVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKELAAAAEKERKAQEKAARQREKLRRREQEAKKS", "length": 424, "header": "tr|A0AAF6DLY9-1|A0AAF6DLY9_BOVIN Isoform 1 of Sterile alpha motif domain containing 14 OS=Bos taurus OX=9913 GN=SAMD14 PE=4 SV=1 CANONICAL=A0AAF6DLY9-1" }, "locus": { "chromosome": "19", "start_pos": 36543190, "end_pos": 36527149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000051851.6", "url": "https://www.ensembl.org/id/ENSBTAT00000051851.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050828.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050828.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DLY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY9" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 333, "end_pos": 396, "start_aa": "Trp", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM00-1", "uniprot_ac": "A0AAF6DM00", "uniprot_id": "A0AAF6DM00_BOVIN", "mass": { "chemical_mass": 33991.0, "monoisotopic_mass": 33991.0 }, "refseq": { "ac": "NP_001076892", "name": "uncharacterized protein NKAPD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076892" }, "gene_names": [ { "name": "NKAPD1", "type": "recommended", "evidence": [ { "id": "A0AAF6DM00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00" } ] }, { "name": "C15H11orf57", "type": "synonym", "evidence": [ { "id": "NP_001076892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076892" } ] }, { "name": "NKAPD1", "type": "synonym", "evidence": [ { "id": "NP_001076892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076892" } ] } ], "protein_names": [ { "name": "NKAP domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAF6DM00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein NKAPD1", "type": "synonym", "evidence": [ { "id": "NP_001076892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076892" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NKAPD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00", "locus": { "chromosome": "15", "start_pos": 22394267, "end_pos": 22383021, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001999", "url": "https://www.ensembl.org/id/ENSBTAG00000001999" } ] } } ], "crossref": [ { "id": "A0AAF6DM00", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM00", "database": "AlphaFoldDB", "categories": [] }, { "id": "513716", "url": "https://www.ncbi.nlm.nih.gov/gene/513716", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46940", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46940", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46940:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46940:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15692", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15692", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001076892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076892", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRVPLGKVLLRNVIRHTDAHNKIQEESDMWKIRELEKQMDDAYRGTKRRMLPSSSSRMRSDGFDEESQRDYWRPKNEICGALDDGFLKAKSWNKKLYDYEANMPDRWGHSGYKELYPEEFETDSSDQQDITNGKKTSPQVKSSTHESHKHKKSKKSHKKKQKKKSHKKQKKSKKEATDITADSSSEFSEETGASSTRKRKQPHKRKKKSRKKSLKKSPLLEAESDTSPSDDSASSSSEESEERDTKKTKRKKREKKAHIPVVNNEIQERTNKRTNWKVATDERSAESSEDD", "length": 292, "header": "tr|A0AAF6DM00-1|A0AAF6DM00_BOVIN Isoform 1 of NKAP domain containing 1 OS=Bos taurus OX=9913 GN=NKAPD1 PE=4 SV=2 CANONICAL=A0AAF6DM00-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00/entry", "sequence": { "sequence": "MSRVPLGKVLLRNVIRHTDAHNKIQEESDMWKIRELEKQMDDAYRGTKRRMLPSSSSRMRSDGFDEESQRDYWRPKNEICGALDDGFLKAKSWNKKLYDYEANMPDRWGHSGYKELYPEEFETDSSDQQDITNGKKTSPQVKSSTHESHKHKKSKKSHKKKQKKKSHKKQKKSKKEATDITADSSSEFSEETGASSTRKRKQPHKRKKKSRKKSLKKSPLLEAESDTSPSDDSASSSSEESEERDTKKTKRKKREKKAHIPVVNNEIQERTNKRTNWKVATDERSAESSEDD", "length": 292, "header": "tr|A0AAF6DM00-1|A0AAF6DM00_BOVIN Isoform 1 of NKAP domain containing 1 OS=Bos taurus OX=9913 GN=NKAPD1 PE=4 SV=2 CANONICAL=A0AAF6DM00-1" }, "locus": { "chromosome": "15", "start_pos": 22393263, "end_pos": 22384427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002592.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002592.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002592.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002592.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM01-1", "uniprot_ac": "A0AAF6DM01", "uniprot_id": "A0AAF6DM01_BOVIN", "mass": { "chemical_mass": 27555.0, "monoisotopic_mass": 27555.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC32", "type": "recommended", "evidence": [ { "id": "A0AAF6DM01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 32", "type": "synonym", "evidence": [ { "id": "A0AAF6DM01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM01", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01", "locus": { "chromosome": "10", "start_pos": 36151426, "end_pos": 36161057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025593", "url": "https://www.ensembl.org/id/ENSBTAG00000025593" } ] } } ], "crossref": [ { "id": "A0AAF6DM01", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM01", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR028039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31800", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31800", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31800:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31800:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM01", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLTSLPSRTPLDQSKHRTSPSWAVVGGFPGSVTWRLRLLISSLLPAKKLSRAFAGCWQAVVLRFQMKMFESIDSTTTRSGPDLWAEICSCLPHPDQEDSASNAFSDSFMDSYPAGTGQREAPHFAAQPAVKPWAPLQDSEVYLASLEKKLRRIKGLNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESTLEHFKRWLQPDKVAISTEEVQYLIPPESQVEKPAPRDEPTAAEQ", "length": 245, "header": "tr|A0AAF6DM01-1|A0AAF6DM01_BOVIN Isoform 1 of Coiled-coil domain containing 32 OS=Bos taurus OX=9913 GN=CCDC32 PE=4 SV=1 CANONICAL=A0AAF6DM01-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01/entry", "sequence": { "sequence": "MQLTSLPSRTPLDQSKHRTSPSWAVVGGFPGSVTWRLRLLISSLLPAKKLSRAFAGCWQAVVLRFQMKMFESIDSTTTRSGPDLWAEICSCLPHPDQEDSASNAFSDSFMDSYPAGTGQREAPHFAAQPAVKPWAPLQDSEVYLASLEKKLRRIKGLNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESTLEHFKRWLQPDKVAISTEEVQYLIPPESQVEKPAPRDEPTAAEQ", "length": 245, "header": "tr|A0AAF6DM01-1|A0AAF6DM01_BOVIN Isoform 1 of Coiled-coil domain containing 32 OS=Bos taurus OX=9913 GN=CCDC32 PE=4 SV=1 CANONICAL=A0AAF6DM01-1" }, "locus": { "chromosome": "10", "start_pos": 36161021, "end_pos": 36152277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036068.4", "url": "https://www.ensembl.org/id/ENSBTAT00000036068.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035932.3", "url": "https://www.ensembl.org/id/ENSBTAP00000035932.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM01", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of clathrin-dependent endocytosis", "id": "GO:2000369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000369", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM01", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01" } ], "pmid": "" }, { "name": "head development", "id": "GO:0060322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060322", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM01", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM03-1", "uniprot_ac": "A0AAF6DM03", "uniprot_id": "A0AAF6DM03_BOVIN", "mass": { "chemical_mass": 31678.0, "monoisotopic_mass": 31678.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC57", "type": "recommended", "evidence": [ { "id": "A0AAF6DM03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 57", "type": "recommended", "evidence": [ { "id": "A0AAF6DM03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM03", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC57", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03", "locus": { "chromosome": "10", "start_pos": 37869708, "end_pos": 37875308, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031981", "url": "https://www.ensembl.org/id/ENSBTAG00000031981" } ] } } ], "crossref": [ { "id": "A0AAF6DM03", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM03", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM03", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSQGVSARAEAWAAHPSERGSRVFPCRTCRELSCTRDLSLGVRMGNSALRAHVETAQKTGVFQLKDRGLTEFPSELQKLTSNLRTIDLSNNKIENLPPMIIGKFTLLKSLSLNNNKLTALPDELCNLKKLETLSLNNNQLRELPSTFGQLSALKTLSLSGNQLRALPPQLCSLRHLDVVDLSKNQIRSILDTVGELQVIELNLNQNQISQISVKISSCPRLKVLRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA", "length": 283, "header": "tr|A0AAF6DM03-1|A0AAF6DM03_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 57 OS=Bos taurus OX=9913 GN=LRRC57 PE=4 SV=1 CANONICAL=A0AAF6DM03-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03/entry", "sequence": { "sequence": "MTSQGVSARAEAWAAHPSERGSRVFPCRTCRELSCTRDLSLGVRMGNSALRAHVETAQKTGVFQLKDRGLTEFPSELQKLTSNLRTIDLSNNKIENLPPMIIGKFTLLKSLSLNNNKLTALPDELCNLKKLETLSLNNNQLRELPSTFGQLSALKTLSLSGNQLRALPPQLCSLRHLDVVDLSKNQIRSILDTVGELQVIELNLNQNQISQISVKISSCPRLKVLRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA", "length": 283, "header": "tr|A0AAF6DM03-1|A0AAF6DM03_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 57 OS=Bos taurus OX=9913 GN=LRRC57 PE=4 SV=1 CANONICAL=A0AAF6DM03-1" }, "locus": { "chromosome": "10", "start_pos": 37875109, "end_pos": 37870595, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045347.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045347.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042745.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042745.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM03" }, { "id": "PF23598", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Disease resistance R13L4/SHOC-2-like LRR", "eco_id": "ECO_0000259", "start_pos": 102, "end_pos": 198, "start_aa": "Ile", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM04-1", "uniprot_ac": "A0AAF6DM04", "uniprot_id": "A0AAF6DM04_BOVIN", "mass": { "chemical_mass": 44808.0, "monoisotopic_mass": 44808.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "SERPINE1 mRNA binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6DM04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04", "locus": {} } ], "crossref": [ { "id": "A0AAF6DM04", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM04", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12299", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12299", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12299:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12299:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLEQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGIRTDKSSASAPDVDDPEAFPALA", "length": 407, "header": "tr|A0AAF6DM04-1|A0AAF6DM04_BOVIN Isoform 1 of SERPINE1 mRNA binding protein 1 OS=Bos taurus OX=9913 GN= PE=1 SV=1 CANONICAL=A0AAF6DM04-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04/entry", "sequence": { "sequence": "MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLEQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGIRTDKSSASAPDVDDPEAFPALA", "length": 407, "header": "tr|A0AAF6DM04-1|A0AAF6DM04_BOVIN Isoform 1 of SERPINE1 mRNA binding protein 1 OS=Bos taurus OX=9913 GN= PE=1 SV=1 CANONICAL=A0AAF6DM04-1" }, "locus": { "chromosome": "3", "start_pos": 77936819, "end_pos": 77922827, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017211.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017211.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017211.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017211.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "PML body organization", "id": "GO:0030578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030578", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" }, { "name": "ribosome hibernation", "id": "GO:0141014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141014", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "translation repressor activity", "id": "GO:0030371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030371", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" }, { "name": "translation elongation factor binding", "id": "GO:0061770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061770", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" }, { "name": "SUMO binding", "id": "GO:0032183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032183", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM04" }, { "id": "SM01233", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01233" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Hyaluronan/mRNA-binding protein", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 313, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 }, { "start_pos": 253, "end_pos": 255 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM21-1", "uniprot_ac": "A0AAF6DM21", "uniprot_id": "A0AAF6DM21_BOVIN", "mass": { "chemical_mass": 17432.0, "monoisotopic_mass": 17432.0 }, "refseq": { "ac": "XP_005226102", "name": "RING finger protein 122 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226102" }, "gene_names": [ { "name": "RNF122", "type": "recommended", "evidence": [ { "id": "A0AAF6DM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ] }, { "name": "RNF122", "type": "synonym", "evidence": [ { "id": "XP_005226102", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226102" } ] } ], "protein_names": [ { "name": "RING finger protein 122", "type": "recommended", "evidence": [ { "id": "A0AAF6DM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 122 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005226102", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226102" } ] } ], "function": [ { "annotation": "May induce necrosis and apoptosis. May play a role in cell viability.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21#function" }, { "database": "UniProtKB", "id": "ARBA00057276", "url": "https://www.uniprot.org/uniprotkb/ARBA00057276#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF122", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21", "locus": { "chromosome": "27", "start_pos": 29247808, "end_pos": 29265790, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016411", "url": "https://www.ensembl.org/id/ENSBTAG00000016411" } ] } } ], "crossref": [ { "id": "A0AAF6DM21", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM21", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16676", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16676", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510037", "url": "https://www.ncbi.nlm.nih.gov/gene/510037", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45931", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45931", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45931:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45931:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005226102", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226102", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPFQWCNGCFCGLGLVSTNKSCSMPPISFQDLPLNIYMVIFGTGIFVFMLSLIFCCYFISKLRNQAQSERYGYKEVVLKGDAKKLQLYGQTCAVCLEDFRGKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPIAGPSEASQSIGILLDELV", "length": 155, "header": "tr|A0AAF6DM21-1|A0AAF6DM21_BOVIN Isoform 1 of RING finger protein 122 OS=Bos taurus OX=9913 GN=RNF122 PE=4 SV=1 CANONICAL=A0AAF6DM21-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21/entry", "sequence": { "sequence": "MHPFQWCNGCFCGLGLVSTNKSCSMPPISFQDLPLNIYMVIFGTGIFVFMLSLIFCCYFISKLRNQAQSERYGYKEVVLKGDAKKLQLYGQTCAVCLEDFRGKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPIAGPSEASQSIGILLDELV", "length": 155, "header": "tr|A0AAF6DM21-1|A0AAF6DM21_BOVIN Isoform 1 of RING finger protein 122 OS=Bos taurus OX=9913 GN=RNF122 PE=4 SV=1 CANONICAL=A0AAF6DM21-1" }, "locus": { "chromosome": "27", "start_pos": 29265411, "end_pos": 29248832, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021827.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021827.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021827.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021827.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" }, { "name": "negative regulation of mitochondrial membrane potential", "id": "GO:0010917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010917", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM21" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 134, "start_aa": "Cys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 20, "end_pos": 22 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM25-1", "uniprot_ac": "A0AAF6DM25", "uniprot_id": "A0AAF6DM25_BOVIN", "mass": { "chemical_mass": 50222.0, "monoisotopic_mass": 50222.0 }, "refseq": { "ac": "NP_001096696", "name": "nuclear receptor subfamily 1 group I member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096696" }, "gene_names": [ { "name": "NR1I2", "type": "recommended", "evidence": [ { "id": "A0AAF6DM25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ] }, { "name": "NR1I2", "type": "synonym", "evidence": [ { "id": "NP_001096696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096696" } ] } ], "protein_names": [ { "name": "Nuclear receptor subfamily 1 group I member 2", "type": "recommended", "evidence": [ { "id": "A0AAF6DM25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25/entry#names_and_taxonomy" } ] }, { "name": "Orphan nuclear receptor PXR", "type": "synonym", "evidence": [ { "id": "A0AAF6DM25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25/entry#names_and_taxonomy" } ] }, { "name": "Pregnane X receptor", "type": "synonym", "evidence": [ { "id": "A0AAF6DM25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25/entry#names_and_taxonomy" } ] }, { "name": "nuclear receptor subfamily 1 group I member 2", "type": "synonym", "evidence": [ { "id": "NP_001096696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096696" } ] } ], "function": [ { "annotation": "Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25#function" }, { "database": "UniProtKB", "id": "ARBA00094202", "url": "https://www.uniprot.org/uniprotkb/ARBA00094202#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NR1I2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25", "locus": { "chromosome": "1", "start_pos": 64639471, "end_pos": 64606698, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019557", "url": "https://www.ensembl.org/id/ENSBTAG00000019557" } ] } } ], "crossref": [ { "id": "A0AAF6DM25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM25", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06934", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06934", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "493713", "url": "https://www.ncbi.nlm.nih.gov/gene/493713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24082:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24082:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001096696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096696", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVGREEEWNHADLMHRGEADSASTNPIIGADEEEECPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAQPRCPFRKGTCEITQKTRRQCQACRLRKCLESGMRKEMIMSDAAVEQRRALIRRKKRERIETRPLGAKGLTEEQQMMIRELTTAQMNTFDSTFVHFKNFRLPDVLSSGRQIPEPLQIQSREEAAKWRKIREDLCSMKLSLQLRGEDGSVWNYKPPADNGGKEIFSLLPHIADVSTYMFKGIINFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETRTWECGRLSYCVEDPAGGFQQLLLEPVLKFHYMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRLVVDQLQERFAMTLKAYIEFNRPQPAHRFLFLKIMAILTELRSLSAEHTQQLLRIHDVHPFATPLMQELFSTTNG", "length": 434, "header": "tr|A0AAF6DM25-1|A0AAF6DM25_BOVIN Isoform 1 of Nuclear receptor subfamily 1 group I member 2 OS=Bos taurus OX=9913 GN=NR1I2 PE=3 SV=2 CANONICAL=A0AAF6DM25-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25/entry", "sequence": { "sequence": "MEVGREEEWNHADLMHRGEADSASTNPIIGADEEEECPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAQPRCPFRKGTCEITQKTRRQCQACRLRKCLESGMRKEMIMSDAAVEQRRALIRRKKRERIETRPLGAKGLTEEQQMMIRELTTAQMNTFDSTFVHFKNFRLPDVLSSGRQIPEPLQIQSREEAAKWRKIREDLCSMKLSLQLRGEDGSVWNYKPPADNGGKEIFSLLPHIADVSTYMFKGIINFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETRTWECGRLSYCVEDPAGGFQQLLLEPVLKFHYMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRLVVDQLQERFAMTLKAYIEFNRPQPAHRFLFLKIMAILTELRSLSAEHTQQLLRIHDVHPFATPLMQELFSTTNG", "length": 434, "header": "tr|A0AAF6DM25-1|A0AAF6DM25_BOVIN Isoform 1 of Nuclear receptor subfamily 1 group I member 2 OS=Bos taurus OX=9913 GN=NR1I2 PE=3 SV=2 CANONICAL=A0AAF6DM25-1" }, "locus": { "chromosome": "1", "start_pos": 64638663, "end_pos": 64628320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026059.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026059.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026059.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026059.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "xenobiotic catabolic process", "id": "GO:0042178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "cellular response to molecule of bacterial origin", "id": "GO:0071219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071219", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "xenobiotic transport", "id": "GO:0042908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042908", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" }, { "name": "nuclear receptor binding", "id": "GO:0016922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 146, "end_pos": 433, "start_aa": "Glu", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM25" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 114, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM28-1", "uniprot_ac": "A0AAF6DM28", "uniprot_id": "A0AAF6DM28_BOVIN", "mass": { "chemical_mass": 21710.0, "monoisotopic_mass": 21710.0 }, "refseq": {}, "gene_names": [ { "name": "TEX36", "type": "recommended", "evidence": [ { "id": "A0AAF6DM28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28" } ] } ], "protein_names": [ { "name": "Testis expressed 36", "type": "synonym", "evidence": [ { "id": "A0AAF6DM28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM28", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEX36", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28", "locus": { "chromosome": "26", "start_pos": 45206923, "end_pos": 45215977, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007011", "url": "https://www.ensembl.org/id/ENSBTAG00000007011" } ] } } ], "crossref": [ { "id": "A0AAF6DM28", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM28", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR35440", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35440", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35440:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35440:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15115", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15115", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM28", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKGRRFNPPLDKDGRWFPHIGLTQKTPESITSTMLKESHSPRLSRQVEEKLPPIYKVREKQAVNNNFPFSAHDNRHSFQDSGFYLDSGLGRKKISPEKRQHVSRNFNLWACDYVPSCLDGFSNNQISYVYKEAVVVPIFRRFPRHHHEIWNTFKFMPQQSYTEFWKKNPKVRFLINKKTNSP", "length": 183, "header": "tr|A0AAF6DM28-1|A0AAF6DM28_BOVIN Isoform 1 of Testis expressed 36 OS=Bos taurus OX=9913 GN=TEX36 PE=4 SV=1 CANONICAL=A0AAF6DM28-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28/entry", "sequence": { "sequence": "MVKGRRFNPPLDKDGRWFPHIGLTQKTPESITSTMLKESHSPRLSRQVEEKLPPIYKVREKQAVNNNFPFSAHDNRHSFQDSGFYLDSGLGRKKISPEKRQHVSRNFNLWACDYVPSCLDGFSNNQISYVYKEAVVVPIFRRFPRHHHEIWNTFKFMPQQSYTEFWKKNPKVRFLINKKTNSP", "length": 183, "header": "tr|A0AAF6DM28-1|A0AAF6DM28_BOVIN Isoform 1 of Testis expressed 36 OS=Bos taurus OX=9913 GN=TEX36 PE=4 SV=1 CANONICAL=A0AAF6DM28-1" }, "locus": { "chromosome": "26", "start_pos": 45215870, "end_pos": 45206927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009227.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009227.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009227.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009227.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM28" }, { "id": "PF15115", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Domain of unknown function with conserved HDNR motif", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 175, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM30-1", "uniprot_ac": "A0AAF6DM30", "uniprot_id": "A0AAF6DM30_BOVIN", "mass": { "chemical_mass": 69237.0, "monoisotopic_mass": 69237.0 }, "refseq": { "ac": "XP_024847361", "name": "interleukin-1 receptor-associated kinase 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847361" }, "gene_names": [ { "name": "IRAK3", "type": "recommended", "evidence": [ { "id": "A0AAF6DM30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ] }, { "name": "IRAK3", "type": "synonym", "evidence": [ { "id": "XP_024847361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847361" } ] }, { "name": "IrakM", "type": "synonym", "evidence": [ { "id": "XP_024847361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847361" } ] } ], "protein_names": [ { "name": "Interleukin-1 receptor-associated kinase 3", "type": "recommended", "evidence": [ { "id": "A0AAF6DM30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30/entry#names_and_taxonomy" } ] }, { "name": "IL-1 receptor-associated kinase M", "type": "synonym", "evidence": [ { "id": "A0AAF6DM30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30/entry#names_and_taxonomy" } ] }, { "name": "Inactive IL-1 receptor-associated kinase 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DM30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30/entry#names_and_taxonomy" } ] }, { "name": "interleukin-1 receptor-associated kinase 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024847361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847361" } ] } ], "function": [ { "annotation": "Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30#function" }, { "database": "UniProtKB", "id": "ARBA00055022", "url": "https://www.uniprot.org/uniprotkb/ARBA00055022#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IRAK3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30", "locus": { "chromosome": "5", "start_pos": 47564303, "end_pos": 47624867, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007636", "url": "https://www.ensembl.org/id/ENSBTAG00000007636" } ] } } ], "crossref": [ { "id": "A0AAF6DM30", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM30", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08796", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08796", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510342", "url": "https://www.ncbi.nlm.nih.gov/gene/510342", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YVEQGKS", "url": "https://omabrowser.org/oma/group/YVEQGKS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24419", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24419", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24419:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24419:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00531", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00531", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024847361", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847361", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWTAGAARSGGTRRALSSHTLLFDLPPALLGEFCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQILQEMGHHRAIHLIANYGATLNPIEQSHREKEFPNMLQKETANVTVDNVLIPERNEKGILLKSSISFHSIVEGTKNFHKDFLIGEGEIFEVYRVEIQNRTYAIKLFKQGGKMQCKKQWKRFLSELEVLLLFRHPNILELAAYFTESEKFCLVYPYMRNGSLFDRLQCVGDTAPLSWHIRIGVLIGTSKAIQYLHNTELCSVICGSISSANILLDDQFQPKLTDFAMAHFRPHLEPQSSAISMTSSSSKHVWYMPEEYIRQGKLSIKTDIYSFGIVIMEVLTGCKVVLDEPKHIQLRDLLIELMEKRGLDSCISFLDKKVPPCPQNFSAKLFSLAGRCAATRAKLRPSMDEVLNILESTQASLYFAEDPPTSLKSFRSPSPLFFDNVPSIPVEDDENQNNPSPPHDQSLRKDRMTQKTPFECSQSEVTFLGFDKKTGSRGNEDSSSRSGSPCEESWSPKCATPSLDLRAPSVHTDTSAEAPGHSYRSRPVETSCSSIFSWNECKLYKKASVSDEDKEESKNC", "length": 615, "header": "tr|A0AAF6DM30-1|A0AAF6DM30_BOVIN Isoform 1 of Interleukin-1 receptor-associated kinase 3 OS=Bos taurus OX=9913 GN=IRAK3 PE=3 SV=1 CANONICAL=A0AAF6DM30-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30/entry", "sequence": { "sequence": "MAWTAGAARSGGTRRALSSHTLLFDLPPALLGEFCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQILQEMGHHRAIHLIANYGATLNPIEQSHREKEFPNMLQKETANVTVDNVLIPERNEKGILLKSSISFHSIVEGTKNFHKDFLIGEGEIFEVYRVEIQNRTYAIKLFKQGGKMQCKKQWKRFLSELEVLLLFRHPNILELAAYFTESEKFCLVYPYMRNGSLFDRLQCVGDTAPLSWHIRIGVLIGTSKAIQYLHNTELCSVICGSISSANILLDDQFQPKLTDFAMAHFRPHLEPQSSAISMTSSSSKHVWYMPEEYIRQGKLSIKTDIYSFGIVIMEVLTGCKVVLDEPKHIQLRDLLIELMEKRGLDSCISFLDKKVPPCPQNFSAKLFSLAGRCAATRAKLRPSMDEVLNILESTQASLYFAEDPPTSLKSFRSPSPLFFDNVPSIPVEDDENQNNPSPPHDQSLRKDRMTQKTPFECSQSEVTFLGFDKKTGSRGNEDSSSRSGSPCEESWSPKCATPSLDLRAPSVHTDTSAEAPGHSYRSRPVETSCSSIFSWNECKLYKKASVSDEDKEESKNC", "length": 615, "header": "tr|A0AAF6DM30-1|A0AAF6DM30_BOVIN Isoform 1 of Interleukin-1 receptor-associated kinase 3 OS=Bos taurus OX=9913 GN=IRAK3 PE=3 SV=1 CANONICAL=A0AAF6DM30-1" }, "locus": { "chromosome": "5", "start_pos": 47624668, "end_pos": 47564746, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033701.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033701.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033611.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033611.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 555, "start_aa": "Thr", "end_pos": 555, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr555", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "B0UYS2-1", "protein_name": "Interleukin-1 receptor-associated kinase 3", "gene_name": "irak3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKHPNIITFTPGSTRNMSGNTEPSTLLFDVPPVLMESFCRLMDSGVDGLGWRTLASRILSSQLEVRCIEMYAVAGKSPTKELMWSWAQRNKTVEDLLKVLDEMGHARARSLFQSQDSCVLKSSSPPHYPTYLRSTGKSCQVSDLHAESVSVEGEKQKCFITYFDVIEGTRHFHQDLKIGGSGFAEVYCGRWGNRSFAVKVFKQENKTDWKALWEKFTKEIEVLQLNQHPNILELWGSFSDSDRFCLVYPFLQNGSLFHRLHEHVDKPLSWQERLNIIKGTAKAVHHLHTSQPCTVICGNITSSNILLDENMQPKLCDFGLARLRPHSVDQSCTIVMNTALHSNLGYLPEEYIRDGKLSVKLDVYSLGVVILETCTGQKVKQESSKNLFLRDVLHSEVEEKGCVDACLRFLDLKFEHWPPAVALCLLRLGLECTGSKMRVRPDMEMVLQRLIPLHPLPAFSEDQPHTLDDTIPPQRPYKSFPIEDDEMHSQLEELHSPRVSKPADPCECSQSEVTFLSNEDRSFLRDCHQESDQRVSSSESVHSDSAARLDLYGSWPVECSCSTETEAQACADCCANGFSQSVVYVTIDDDNALPAPNDARNPAKEKMKNKIHLYNQGLIKTEELLSLQSE", "length": 630 }, "evidence": [ { "id": "A0AAF6DM30", "url": "https://omabrowser.org/oma/group/A0AAF6DM30/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B2RYC8-1", "protein_name": "Interleukin-1 receptor-associated kinase 3", "gene_name": "Irak3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGPCGARGTLSPHSLLFDLPPALLGELCTILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVHQGKSGTRELLWSWAQKNKTIGDLLQVLHEMGHQRAIHLIMNYGVNWTPPVQTHHELRFPNLPPNSKPVCRESDPGPLELANVTVDNVLVPEHNERGVVLHKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVEIRNQTYAVKLFKQEKTMQLKKHWKRFLSELEVLLLFNHPHILELAAYFTEMEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQCLHNTRPCAVICGNISSANILLDDQFQPKLTDFAAAHFRPHLEQQSSTINMTGSGRKHLWYMPEEYIRQGRLTIKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELVEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGQCVATRAKLRPTMDEVLNTLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNYPVPPKEALRTDRVTQKTPFECSQSEVTFLGLDRNKGNRGSEAACNMPSSSCEECWCPELAEASQDLRPTVISLGSSWEVPGYSYGSKPMEKRCSSGLFCSEHEQSKRQ", "length": 610 }, "evidence": [ { "id": "A0AAF6DM30", "url": "https://omabrowser.org/oma/group/A0AAF6DM30/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K4B2-1", "protein_name": "Interleukin-1 receptor-associated kinase 3", "gene_name": "Irak3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIHLIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNVLVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNHSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ", "length": 609 }, "evidence": [ { "id": "A0AAF6DM30", "url": "https://omabrowser.org/oma/group/A0AAF6DM30/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y616-1", "protein_name": "Interleukin-1 receptor-associated kinase 3", "gene_name": "IRAK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE", "length": 596 }, "evidence": [ { "id": "A0AAF6DM30", "url": "https://omabrowser.org/oma/group/A0AAF6DM30/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "negative regulation of cytokine-mediated signaling pathway", "id": "GO:0001960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001960", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "interleukin-1-mediated signaling pathway", "id": "GO:0070498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070498", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor production", "id": "GO:0032720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "response to exogenous dsRNA", "id": "GO:0043330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043330", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "lipopolysaccharide-mediated signaling pathway", "id": "GO:0031663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031663", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of interleukin-12 production", "id": "GO:0032695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032695", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of toll-like receptor signaling pathway", "id": "GO:0034122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of MAPK cascade", "id": "GO:0043409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043409", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of macrophage cytokine production", "id": "GO:0010936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010936", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of innate immune response", "id": "GO:0045824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045824", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "response to peptidoglycan", "id": "GO:0032494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032494", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "negative regulation of protein-containing complex disassembly", "id": "GO:0043242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043242", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "positive regulation of macrophage tolerance induction", "id": "GO:0010933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010933", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" }, { "id": "PS50017", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50017" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Death", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 112, "start_aa": "Trp", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM30" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 458, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 555 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 192, "end_pos": 194 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 419, "end_pos": 421 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM51-1", "uniprot_ac": "A0AAF6DM51", "uniprot_id": "A0AAF6DM51_BOVIN", "mass": { "chemical_mass": 62087.0, "monoisotopic_mass": 62087.0 }, "refseq": {}, "gene_names": [ { "name": "SELENON", "type": "recommended", "evidence": [ { "id": "A0AAF6DM51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ] } ], "protein_names": [ { "name": "Selenoprotein N", "type": "synonym", "evidence": [ { "id": "A0AAF6DM51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SELENON", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51", "locus": { "chromosome": "2", "start_pos": 127256063, "end_pos": 127273838, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021778", "url": "https://www.ensembl.org/id/ENSBTAG00000021778" } ] } } ], "crossref": [ { "id": "A0AAF6DM51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM51", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16213", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16213", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16213:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16213:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRTRPGERGPPGSGPAAPPAPPPRRARALALLGALLAAAAAAAAARAFARYSEAQAAARQDSALKTLGTEGLFLFSSLDTDRDMYISPEEFKPIAEKLTGSTPTANYEEEELPPDPSEETLTIEARFQPLLPESMTKSKDGFLGVSRLALSGLRNWTTAASPSAVFAARHFRPFLPPQGHVELGEPWWIIPSELSVFTGYLSNNRFYPPPPKGKEVIIHRLLSMFHPRPFVKTRFAPQGAVACLTAISDFYYTVMFRIHAEFQLSEPPDFPFWFSPGQFTGHVVLSKDATHVRDFRLFVPNHRSLNVDMEWLYGASESSNMEVDIGYIPQMELEALGPSVPSVILDEDGNLIDSRLPSGEPLQFVFEEIQWQQELSWEEAARRLEVAMYPFKKVTYLPFTEAFDQAKAKNKLVHSILLWGALDDQSCGSGRTLRETVLESSPILALLNESFISTWSLVKELEDLQNNQENPSHQKLAGLHLEKYSFPVEMMICLPNGTVVHHINANYFLDITSMKPEDIENHVFSFSSTFEDPSTATYMQFLKEGLRRGLPLLQP", "length": 556, "header": "tr|A0AAF6DM51-1|A0AAF6DM51_BOVIN Isoform 1 of Selenoprotein N OS=Bos taurus OX=9913 GN=SELENON PE=4 SV=2 CANONICAL=A0AAF6DM51-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51/entry", "sequence": { "sequence": "MGRTRPGERGPPGSGPAAPPAPPPRRARALALLGALLAAAAAAAAARAFARYSEAQAAARQDSALKTLGTEGLFLFSSLDTDRDMYISPEEFKPIAEKLTGSTPTANYEEEELPPDPSEETLTIEARFQPLLPESMTKSKDGFLGVSRLALSGLRNWTTAASPSAVFAARHFRPFLPPQGHVELGEPWWIIPSELSVFTGYLSNNRFYPPPPKGKEVIIHRLLSMFHPRPFVKTRFAPQGAVACLTAISDFYYTVMFRIHAEFQLSEPPDFPFWFSPGQFTGHVVLSKDATHVRDFRLFVPNHRSLNVDMEWLYGASESSNMEVDIGYIPQMELEALGPSVPSVILDEDGNLIDSRLPSGEPLQFVFEEIQWQQELSWEEAARRLEVAMYPFKKVTYLPFTEAFDQAKAKNKLVHSILLWGALDDQSCGSGRTLRETVLESSPILALLNESFISTWSLVKELEDLQNNQENPSHQKLAGLHLEKYSFPVEMMICLPNGTVVHHINANYFLDITSMKPEDIENHVFSFSSTFEDPSTATYMQFLKEGLRRGLPLLQP", "length": 556, "header": "tr|A0AAF6DM51-1|A0AAF6DM51_BOVIN Isoform 1 of Selenoprotein N OS=Bos taurus OX=9913 GN=SELENON PE=4 SV=2 CANONICAL=A0AAF6DM51-1" }, "locus": { "chromosome": "2", "start_pos": 127273838, "end_pos": 127258890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029033.8", "url": "https://www.ensembl.org/id/ENSBTAT00000029033.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029033.8", "url": "https://www.ensembl.org/id/ENSBTAP00000029033.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of response to oxidative stress", "id": "GO:1902884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902884", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" }, { "name": "calcium ion homeostasis", "id": "GO:0055074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055074", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" }, { "name": "skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration", "id": "GO:0014834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014834", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM51" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 102, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 497, "end_pos": 499 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM60-1", "uniprot_ac": "A0AAF6DM60", "uniprot_id": "A0AAF6DM60_BOVIN", "mass": { "chemical_mass": 69557.0, "monoisotopic_mass": 69557.0 }, "refseq": { "ac": "XP_005224942", "name": "zinc finger protein 48 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224942" }, "gene_names": [ { "name": "ZNF48", "type": "recommended", "evidence": [ { "id": "A0AAF6DM60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ] }, { "name": "ZNF48", "type": "synonym", "evidence": [ { "id": "XP_005224942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224942" } ] }, { "name": "ZNF553", "type": "synonym", "evidence": [ { "id": "XP_005224942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224942" } ] } ], "protein_names": [ { "name": "Zinc finger protein 48", "type": "recommended", "evidence": [ { "id": "A0AAF6DM60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 553", "type": "synonym", "evidence": [ { "id": "A0AAF6DM60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 48 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005224942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224942" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60", "locus": { "chromosome": "25", "start_pos": 26579790, "end_pos": 26575271, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031806", "url": "https://www.ensembl.org/id/ENSBTAG00000031806" } ] } } ], "crossref": [ { "id": "A0AAF6DM60", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM60", "database": "AlphaFoldDB", "categories": [] }, { "id": "512477", "url": "https://www.ncbi.nlm.nih.gov/gene/512477", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224942", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224942", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERAVGPWGSDLRSSEEREQLRGARTGEGRSGAPPWAGLGSEHAEISQPDEFEHAPQEDDLEFKEEEDLAPGHEVGNASLKPEGIQTWDDLWVQREGPGKPQARDRGPRLLGEPRWGQASDRAAVCGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHSGEKPYRARAPAQGPPKIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRTHRGEQPPRPVVPRRQPSRAATAAAQGPKAQDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGERPHACPECDRTFSLSSTLLRHRLTHMEPQDFSFPGYPLAPLIPSPPPSSSPPPPPLGTSPPLTPRSPSHSGDGPFGLPGLEPEPGGPQAGEPPPPLEGDKPHKCPECGKGFRRSSDLMKHHRVHTGEKPYLCPECGKGFADSSARVKHLRTHRGERARPPPPSTLLRPHNPPGPAPTAPRSRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKPYKCAECGKGFGDSSARIKHQRGHLILRPFGTGDGRARPLKEEPPMGLE", "length": 637, "header": "tr|A0AAF6DM60-1|A0AAF6DM60_BOVIN Isoform 1 of Zinc finger protein 48 OS=Bos taurus OX=9913 GN=ZNF48 PE=3 SV=1 CANONICAL=A0AAF6DM60-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60/entry", "sequence": { "sequence": "MERAVGPWGSDLRSSEEREQLRGARTGEGRSGAPPWAGLGSEHAEISQPDEFEHAPQEDDLEFKEEEDLAPGHEVGNASLKPEGIQTWDDLWVQREGPGKPQARDRGPRLLGEPRWGQASDRAAVCGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHSGEKPYRARAPAQGPPKIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRTHRGEQPPRPVVPRRQPSRAATAAAQGPKAQDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGERPHACPECDRTFSLSSTLLRHRLTHMEPQDFSFPGYPLAPLIPSPPPSSSPPPPPLGTSPPLTPRSPSHSGDGPFGLPGLEPEPGGPQAGEPPPPLEGDKPHKCPECGKGFRRSSDLMKHHRVHTGEKPYLCPECGKGFADSSARVKHLRTHRGERARPPPPSTLLRPHNPPGPAPTAPRSRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKPYKCAECGKGFGDSSARIKHQRGHLILRPFGTGDGRARPLKEEPPMGLE", "length": 637, "header": "tr|A0AAF6DM60-1|A0AAF6DM60_BOVIN Isoform 1 of Zinc finger protein 48 OS=Bos taurus OX=9913 GN=ZNF48 PE=3 SV=1 CANONICAL=A0AAF6DM60-1" }, "locus": { "chromosome": "25", "start_pos": 26578833, "end_pos": 26575638, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028273.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028273.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028273.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028273.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 545, "start_aa": "Thr", "end_pos": 545, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr545", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM60" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 124, "end_pos": 151, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 545 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM61-1", "uniprot_ac": "A0AAF6DM61", "uniprot_id": "A0AAF6DM61_BOVIN", "mass": { "chemical_mass": 79492.0, "monoisotopic_mass": 79492.0 }, "refseq": {}, "gene_names": [ { "name": "VASN", "type": "recommended", "evidence": [ { "id": "A0AAF6DM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ] } ], "protein_names": [ { "name": "Vasorin", "type": "recommended", "evidence": [ { "id": "A0AAF6DM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61/entry#names_and_taxonomy" } ] }, { "name": "Protein slit-like 2", "type": "synonym", "evidence": [ { "id": "A0AAF6DM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May act as an inhibitor of TGF-beta signaling.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61#function" }, { "database": "UniProtKB", "id": "ARBA00059920", "url": "https://www.uniprot.org/uniprotkb/ARBA00059920#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VASN", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61", "locus": { "chromosome": "25", "start_pos": 3540694, "end_pos": 3526049, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046339", "url": "https://www.ensembl.org/id/ENSBTAG00000046339" } ] } } ], "crossref": [ { "id": "A0AAF6DM61", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM61", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF160", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF160", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGDPLWSISRLGVLSGDTTQTLSPSLHPGPLQGGQSPPPLVLSSRLRDGGPGGRGSLPPPPQELSCWLRPGQGPEMHSRAPLRLLLPLLLLLPALGPGVQGCPSGCQCNQPRTVFCTARRGTTVPLDVPPDTVGLYIFENGITTLDAGSFAGLPGLQLLDLSQNQIASLPGGVFQPLANLSNLDLTANRLREITNETFRGLRRLERLYLGKNRIRHIQPGAFDVFDRLLELKLQDNELRALPPLRLPRLLLLDLSHNGLSALEPGVLDTANVETLRLAGLGLRHLDEGLFGRLRNLHNLDVADNQLERVPPAVRGLRGLTRLRLAGNTRIAQLWLEDLAGLAALQELDLSNLSLQALPHELSTLFPRLRLLEAARNPFNCVCPLSWFGPWVRESRLTLASPEETRCHFPPKNAGRLLLDLDYSDFGCPATTTTATAPTTRAPVQEPTLPPSSLAPTQLRPTELATEAPSQPPPAPPTAGPVPPPRDCPASICLNGGTCHLGARGHLECLCPQGFTGLYCEGRVRPGPRPSPAPATPRPLPLGIEPASPTSLRVGLQRFQQGSAVQLKSLRLTYRNLSGPDKRPVTLRLPASLAEYTVTQLRPNATYSICVRALGAGRVPEGEEACGEARTPPAVRSNHAPVTQAREGNLPLLIAPALAAVLLAVLAAVGAAFCVRRGRAAAAVVQGKGQVGPGAGPLELEGVKAPLEPDPKALEGGGEAPTGGLECEVPLMGYSGPGPQGPLPAKPYI", "length": 749, "header": "tr|A0AAF6DM61-1|A0AAF6DM61_BOVIN Isoform 1 of Vasorin OS=Bos taurus OX=9913 GN=VASN PE=4 SV=1 CANONICAL=A0AAF6DM61-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61/entry", "sequence": { "sequence": "MAGDPLWSISRLGVLSGDTTQTLSPSLHPGPLQGGQSPPPLVLSSRLRDGGPGGRGSLPPPPQELSCWLRPGQGPEMHSRAPLRLLLPLLLLLPALGPGVQGCPSGCQCNQPRTVFCTARRGTTVPLDVPPDTVGLYIFENGITTLDAGSFAGLPGLQLLDLSQNQIASLPGGVFQPLANLSNLDLTANRLREITNETFRGLRRLERLYLGKNRIRHIQPGAFDVFDRLLELKLQDNELRALPPLRLPRLLLLDLSHNGLSALEPGVLDTANVETLRLAGLGLRHLDEGLFGRLRNLHNLDVADNQLERVPPAVRGLRGLTRLRLAGNTRIAQLWLEDLAGLAALQELDLSNLSLQALPHELSTLFPRLRLLEAARNPFNCVCPLSWFGPWVRESRLTLASPEETRCHFPPKNAGRLLLDLDYSDFGCPATTTTATAPTTRAPVQEPTLPPSSLAPTQLRPTELATEAPSQPPPAPPTAGPVPPPRDCPASICLNGGTCHLGARGHLECLCPQGFTGLYCEGRVRPGPRPSPAPATPRPLPLGIEPASPTSLRVGLQRFQQGSAVQLKSLRLTYRNLSGPDKRPVTLRLPASLAEYTVTQLRPNATYSICVRALGAGRVPEGEEACGEARTPPAVRSNHAPVTQAREGNLPLLIAPALAAVLLAVLAAVGAAFCVRRGRAAAAVVQGKGQVGPGAGPLELEGVKAPLEPDPKALEGGGEAPTGGLECEVPLMGYSGPGPQGPLPAKPYI", "length": 749, "header": "tr|A0AAF6DM61-1|A0AAF6DM61_BOVIN Isoform 1 of Vasorin OS=Bos taurus OX=9913 GN=VASN PE=4 SV=1 CANONICAL=A0AAF6DM61-1" }, "locus": { "chromosome": "25", "start_pos": 3536129, "end_pos": 3533209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063699.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063699.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055273.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055273.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 478, "start_aa": "Thr", "end_pos": 478, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr478", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 722, "start_aa": "Thr", "end_pos": 722, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr722", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transforming growth factor beta binding", "id": "GO:0050431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050431", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" }, { "name": "negative regulation of epithelial to mesenchymal transition", "id": "GO:0010719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010719", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM61", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 484, "end_pos": 521, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM61" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 538, "end_pos": 634, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 478, 722 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 576, "end_pos": 578 }, { "start_pos": 604, "end_pos": 606 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM62-1", "uniprot_ac": "A0AAF6DM62", "uniprot_id": "A0AAF6DM62_BOVIN", "mass": { "chemical_mass": 64886.0, "monoisotopic_mass": 64886.0 }, "refseq": { "ac": "NP_001421678", "name": "KH homology domain-containing protein 4 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421678" }, "gene_names": [ { "name": "KHDC4", "type": "recommended", "evidence": [ { "id": "A0AAF6DM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ] }, { "name": "KHDC4", "type": "synonym", "evidence": [ { "id": "NP_001421678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421678" } ] }, { "name": "KIAA0907", "type": "synonym", "evidence": [ { "id": "NP_001421678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421678" } ] } ], "protein_names": [ { "name": "KH homology domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "A0AAF6DM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62/entry#names_and_taxonomy" } ] }, { "name": "Brings lots of money 7", "type": "synonym", "evidence": [ { "id": "A0AAF6DM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62/entry#names_and_taxonomy" } ] }, { "name": "KH homology domain-containing protein 4 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421678" } ] }, { "name": "Pre-mRNA Splicing factor protein khdc4", "type": "synonym", "evidence": [ { "id": "A0AAF6DM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62#function" }, { "database": "UniProtKB", "id": "ARBA00045732", "url": "https://www.uniprot.org/uniprotkb/ARBA00045732#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KHDC4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62", "locus": { "chromosome": "3", "start_pos": 14852135, "end_pos": 14834858, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000108", "url": "https://www.ensembl.org/id/ENSBTAG00000000108" } ] } } ], "crossref": [ { "id": "A0AAF6DM62", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM62", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22385", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22385", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22386", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22386", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530205", "url": "https://www.ncbi.nlm.nih.gov/gene/530205", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15744", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15744", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15744:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15744:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22675", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22675", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23469", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23469", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421678", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAGSATHPGAGGRRSKWDQPAPAPLLFLPPATPGGEVTSSGGSPGGSTAAPSGALDAAAAVAAKINAMLMAKGKLKPTQNAAEKLQAPGKGLTSNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGTSPTFNGATVTVYHQPAPIAQLSPAVSQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCTYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQINTAVPLPGYTQPSAISSVPPQPPYYPSNGYQSGYPVVPPPQQPVQPPYGVPSIVPPAVSLAPGVLPALPTGVPPVPTQYPITQVQPPASTGQSPMSGPFIPAAPVKTALPAGPQPPPQPQPPLPSQPQAQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQNEIEGAGSKPASSSGKERERDRQLMPPPAFPVTGIKTESDERNGSGTLTGSHDYPVKKMKTTEKGFGLVAYAADSSDEEEEHGGHKNASSFPQGWSLGYQYPSSQPRAKQQMPFWMAP", "length": 614, "header": "tr|A0AAF6DM62-1|A0AAF6DM62_BOVIN Isoform 1 of KH homology domain-containing protein 4 OS=Bos taurus OX=9913 GN=KHDC4 PE=3 SV=1 CANONICAL=A0AAF6DM62-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62/entry", "sequence": { "sequence": "MSAGSATHPGAGGRRSKWDQPAPAPLLFLPPATPGGEVTSSGGSPGGSTAAPSGALDAAAAVAAKINAMLMAKGKLKPTQNAAEKLQAPGKGLTSNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGTSPTFNGATVTVYHQPAPIAQLSPAVSQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCTYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQINTAVPLPGYTQPSAISSVPPQPPYYPSNGYQSGYPVVPPPQQPVQPPYGVPSIVPPAVSLAPGVLPALPTGVPPVPTQYPITQVQPPASTGQSPMSGPFIPAAPVKTALPAGPQPPPQPQPPLPSQPQAQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQNEIEGAGSKPASSSGKERERDRQLMPPPAFPVTGIKTESDERNGSGTLTGSHDYPVKKMKTTEKGFGLVAYAADSSDEEEEHGGHKNASSFPQGWSLGYQYPSSQPRAKQQMPFWMAP", "length": 614, "header": "tr|A0AAF6DM62-1|A0AAF6DM62_BOVIN Isoform 1 of KH homology domain-containing protein 4 OS=Bos taurus OX=9913 GN=KHDC4 PE=3 SV=1 CANONICAL=A0AAF6DM62-1" }, "locus": { "chromosome": "3", "start_pos": 14851048, "end_pos": 14834887, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000119.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000119.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000119.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000119.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 33, "start_aa": "Thr", "end_pos": 33, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splice site recognition", "id": "GO:0006376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006376", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM62", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" }, { "id": "PF23469", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23469" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 187, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM62" }, { "id": "PF22675", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22675" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KHDC4/BBP-like KH-domain type I", "eco_id": "ECO_0000259", "start_pos": 244, "end_pos": 317, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 33 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 539, "end_pos": 541 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM76-1", "uniprot_ac": "A0AAF6DM76", "uniprot_id": "A0AAF6DM76_BOVIN", "mass": { "chemical_mass": 52054.0, "monoisotopic_mass": 52054.0 }, "refseq": { "ac": "XP_005220155", "name": "inositol polyphosphate 5-phosphatase K isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220155" }, "gene_names": [ { "name": "INPP5K", "type": "recommended", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ] }, { "name": "INPP5K", "type": "synonym", "evidence": [ { "id": "XP_005220155", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220155" } ] }, { "name": "SKIP", "type": "synonym", "evidence": [ { "id": "XP_005220155", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220155" } ] } ], "protein_names": [ { "name": "Inositol polyphosphate 5-phosphatase K", "type": "recommended", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.36", "type": "synonym", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.56", "type": "synonym", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.86", "type": "synonym", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-4,5-bisphosphate 5-phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "Skeletal muscle and kidney-enriched inositol phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry#names_and_taxonomy" } ] }, { "name": "inositol polyphosphate 5-phosphatase K isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005220155", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220155" } ] } ], "function": [ { "annotation": "Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76#function" }, { "database": "UniProtKB", "id": "ARBA00057102", "url": "https://www.uniprot.org/uniprotkb/ARBA00057102#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INPP5K", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76", "locus": { "chromosome": "19", "start_pos": 22622695, "end_pos": 22641597, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011479", "url": "https://www.ensembl.org/id/ENSBTAG00000011479" } ] } } ], "crossref": [ { "id": "A0AAF6DM76", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM76", "database": "AlphaFoldDB", "categories": [] }, { "id": "514123", "url": "https://www.ncbi.nlm.nih.gov/gene/514123", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11200:SF117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11200:SF117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17751", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17751", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005220155", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220155", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAMSPRTEPRCRTLSIHVVTWNVASAAPPPDLSDLLQLNNLDLDLDIYVIGLQELNCGIMSLLSDTAFEDPWSSYFMDVLSPLSFVKVSSVRMQGLLLLIFAKYQHLPFIQVLSTKSTPTGLFGYWGNKGGVNIFLKLYGYYVSIINCHLPPHMANNDQRLEHFDRILEMQNFEAQDTPNILDHDLILWFGDMNFRIEDFGLHFVRESIKNQRYSDLWEKDQLSIAKRHDPLLREFQEGSLLFPPTYKFDKNSNNYDTSEKKRKPAWTDRILWRLKRQSQTDFQTPELSAPFALFLRSYVSHMVYTISDHKPVTCTFDLELKPLVSAPLITLLPKGPCTMENDLLISYCLAADFLSSPWDWIGLYKVGLRHINDYVSYVWVKDNQVSFSDRLNQVYIDISDIPETEDQFLLFYYSNNLHSVVGISKPFKIQPFSFLEEDPLDEAQPQI", "length": 449, "header": "tr|A0AAF6DM76-1|A0AAF6DM76_BOVIN Isoform 1 of Inositol polyphosphate 5-phosphatase K OS=Bos taurus OX=9913 GN=INPP5K PE=3 SV=1 CANONICAL=A0AAF6DM76-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76/entry", "sequence": { "sequence": "MEAMSPRTEPRCRTLSIHVVTWNVASAAPPPDLSDLLQLNNLDLDLDIYVIGLQELNCGIMSLLSDTAFEDPWSSYFMDVLSPLSFVKVSSVRMQGLLLLIFAKYQHLPFIQVLSTKSTPTGLFGYWGNKGGVNIFLKLYGYYVSIINCHLPPHMANNDQRLEHFDRILEMQNFEAQDTPNILDHDLILWFGDMNFRIEDFGLHFVRESIKNQRYSDLWEKDQLSIAKRHDPLLREFQEGSLLFPPTYKFDKNSNNYDTSEKKRKPAWTDRILWRLKRQSQTDFQTPELSAPFALFLRSYVSHMVYTISDHKPVTCTFDLELKPLVSAPLITLLPKGPCTMENDLLISYCLAADFLSSPWDWIGLYKVGLRHINDYVSYVWVKDNQVSFSDRLNQVYIDISDIPETEDQFLLFYYSNNLHSVVGISKPFKIQPFSFLEEDPLDEAQPQI", "length": 449, "header": "tr|A0AAF6DM76-1|A0AAF6DM76_BOVIN Isoform 1 of Inositol polyphosphate 5-phosphatase K OS=Bos taurus OX=9913 GN=INPP5K PE=3 SV=1 CANONICAL=A0AAF6DM76-1" }, "locus": { "chromosome": "19", "start_pos": 22641479, "end_pos": 22623947, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015257.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015257.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015257.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015257.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "negative regulation of D-glucose transmembrane transport", "id": "GO:0010829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "positive regulation of urine volume", "id": "GO:0035810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035810", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of calcium ion transport", "id": "GO:0051926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051926", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "id": "GO:0045869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "ruffle assembly", "id": "GO:0097178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097178", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of stress fiber assembly", "id": "GO:0051497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of dephosphorylation", "id": "GO:0035305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035305", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "host-mediated suppression of viral transcription", "id": "GO:0043922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043922", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of protein targeting to membrane", "id": "GO:0090315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090315", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "negative regulation of glycogen biosynthetic process", "id": "GO:0045719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045719", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "positive regulation of renal water transport", "id": "GO:2001153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001153", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "vasopressin receptor activity", "id": "GO:0005000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005000", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "id": "GO:0004439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004439", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "inositol-polyphosphate 5-phosphatase activity", "id": "GO:0004445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "inositol bisphosphate phosphatase activity", "id": "GO:0016312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016312", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM76", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM76" }, { "id": "SM00128", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Inositol polyphosphate-related phosphatase", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 326, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.86", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "3.1.3.86", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86" }, { "id": "3.1.3.86", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.86" } ] }, { "ec_number": "3.1.3.56", "ec_name": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "3.1.3.56", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56" }, { "id": "3.1.3.56", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.56" } ] }, { "ec_number": "3.1.3.36", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "3.1.3.36", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36" }, { "id": "3.1.3.36", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.36" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM79-1", "uniprot_ac": "A0AAF6DM79", "uniprot_id": "A0AAF6DM79_BOVIN", "mass": { "chemical_mass": 107512.0, "monoisotopic_mass": 107512.0 }, "refseq": {}, "gene_names": [ { "name": "SAFB", "type": "recommended", "evidence": [ { "id": "A0AAF6DM79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" } ] } ], "protein_names": [ { "name": "Scaffold attachment factor B", "type": "synonym", "evidence": [ { "id": "A0AAF6DM79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAFB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79", "locus": { "chromosome": "7", "start_pos": 18621612, "end_pos": 18651614, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007875", "url": "https://www.ensembl.org/id/ENSBTAG00000007875" } ] } } ], "crossref": [ { "id": "A0AAF6DM79", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM79", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12679", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12679", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15683", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15683", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15683:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15683:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRGRERRTRAGYACAEASRTGAAGAVLSQAAPFCAESRGKPGRVLCEVVGGARVPGMAESLSGLGDSGAAGAAALSSASSETGTRRLTDLRVIDLRAELKKRNLDSSGNKSALMERLRKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDMMDISVLDEAEIDNGSVADCVEDDDAENLQESLSDSRELVEGEMKELPEQLQEHAVEDKESINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPIGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSVEDDSDTKKLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPAGKKSSERREGEGKKEKSSNTDRSANLKREEKADRKDDAKKGEDGSGEKSEDQDDQKPGSSERSRATKSGSRGTERTVVMDKSKGVPVISVKTLGSKERVSKSQDRKSASREKRSVVSFDEVKESRKSRDSESRRLREHSEREQSMQAELERQERKKLLIARERLAFHRHRLERERMERERLERERRRVEHERRREQERIHHEREELRRQQELRYEQERRPAVRRPYDYGRRDDVYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSIMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRGRREWGDHGRRIEEDRAWQGAADGGLMDRDHRRWQGGERSMSGHMMNRGGMSGRGSFAPGGASRGHVIPRGGFGSRPTDAHFTRRY", "length": 961, "header": "tr|A0AAF6DM79-1|A0AAF6DM79_BOVIN Isoform 1 of Scaffold attachment factor B OS=Bos taurus OX=9913 GN=SAFB PE=4 SV=1 CANONICAL=A0AAF6DM79-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79/entry", "sequence": { "sequence": "MGRRGRERRTRAGYACAEASRTGAAGAVLSQAAPFCAESRGKPGRVLCEVVGGARVPGMAESLSGLGDSGAAGAAALSSASSETGTRRLTDLRVIDLRAELKKRNLDSSGNKSALMERLRKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDMMDISVLDEAEIDNGSVADCVEDDDAENLQESLSDSRELVEGEMKELPEQLQEHAVEDKESINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPIGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSVEDDSDTKKLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPAGKKSSERREGEGKKEKSSNTDRSANLKREEKADRKDDAKKGEDGSGEKSEDQDDQKPGSSERSRATKSGSRGTERTVVMDKSKGVPVISVKTLGSKERVSKSQDRKSASREKRSVVSFDEVKESRKSRDSESRRLREHSEREQSMQAELERQERKKLLIARERLAFHRHRLERERMERERLERERRRVEHERRREQERIHHEREELRRQQELRYEQERRPAVRRPYDYGRRDDVYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSIMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRGRREWGDHGRRIEEDRAWQGAADGGLMDRDHRRWQGGERSMSGHMMNRGGMSGRGSFAPGGASRGHVIPRGGFGSRPTDAHFTRRY", "length": 961, "header": "tr|A0AAF6DM79-1|A0AAF6DM79_BOVIN Isoform 1 of Scaffold attachment factor B OS=Bos taurus OX=9913 GN=SAFB PE=4 SV=1 CANONICAL=A0AAF6DM79-1" }, "locus": { "chromosome": "7", "start_pos": 18651415, "end_pos": 18621800, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002344.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002344.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002344.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002344.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 464, "end_pos": 542, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM79" }, { "id": "PS50800", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50800" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAP", "eco_id": "ECO_0000259", "start_pos": 89, "end_pos": 123, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 333, "end_pos": 335 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM90-1", "uniprot_ac": "A0AAF6DM90", "uniprot_id": "A0AAF6DM90_BOVIN", "mass": { "chemical_mass": 34741.0, "monoisotopic_mass": 34741.0 }, "refseq": {}, "gene_names": [ { "name": "TP53I3", "type": "recommended", "evidence": [ { "id": "A0AAF6DM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90" } ] } ], "protein_names": [ { "name": "Tumor protein p53 inducible protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TP53I3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90", "locus": { "chromosome": "11", "start_pos": 74989981, "end_pos": 74983559, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003405", "url": "https://www.ensembl.org/id/ENSBTAG00000003405" } ] } } ], "crossref": [ { "id": "A0AAF6DM90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM90", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05276", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05276", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48106:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48106:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00107", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00107", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIAVHFDKPGGPENLYLKEVAKPSPGEGEVLLKVAASALNRADLLQRQGQYAPPPGASNILGLEASGHVAELGAGCQGPWRVGDPAMVLLSGGGQAQYVTVPAELLMPIPAGLTMCQAAAIPEAWLTAFQLLHLVGNVQAGDSVLIHAGASGVGTAAIQLARMAGATPLVTAGSQEKLQIAEKLGAAAGFNYKEEDFSEATLKLTKGAGVNLILDCIGGSYWEKNVNCLALDGHWVLYGLLGGAVISGPLFSKLLFKRGSLITSLLRPRDKKMLVKAFTEQILPHFSTEGPQRLLPVLDRVYPVAEIQEAHEYMETNKNVGKIVLELPQ", "length": 329, "header": "tr|A0AAF6DM90-1|A0AAF6DM90_BOVIN Isoform 1 of Tumor protein p53 inducible protein 3 OS=Bos taurus OX=9913 GN=TP53I3 PE=4 SV=1 CANONICAL=A0AAF6DM90-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90/entry", "sequence": { "sequence": "MIAVHFDKPGGPENLYLKEVAKPSPGEGEVLLKVAASALNRADLLQRQGQYAPPPGASNILGLEASGHVAELGAGCQGPWRVGDPAMVLLSGGGQAQYVTVPAELLMPIPAGLTMCQAAAIPEAWLTAFQLLHLVGNVQAGDSVLIHAGASGVGTAAIQLARMAGATPLVTAGSQEKLQIAEKLGAAAGFNYKEEDFSEATLKLTKGAGVNLILDCIGGSYWEKNVNCLALDGHWVLYGLLGGAVISGPLFSKLLFKRGSLITSLLRPRDKKMLVKAFTEQILPHFSTEGPQRLLPVLDRVYPVAEIQEAHEYMETNKNVGKIVLELPQ", "length": 329, "header": "tr|A0AAF6DM90-1|A0AAF6DM90_BOVIN Isoform 1 of Tumor protein p53 inducible protein 3 OS=Bos taurus OX=9913 GN=TP53I3 PE=4 SV=1 CANONICAL=A0AAF6DM90-1" }, "locus": { "chromosome": "11", "start_pos": 74989422, "end_pos": 74983666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004413.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004413.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004413.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004413.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 100, "start_aa": "Thr", "end_pos": 100, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr100", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "reactive oxygen species biosynthetic process", "id": "GO:1903409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903409", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "quinone reductase (NADPH) activity", "id": "GO:0003960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003960", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM90" }, { "id": "SM00829", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Enoyl reductase (ER)", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 325, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 100 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMA0-1", "uniprot_ac": "A0AAF6DMA0", "uniprot_id": "A0AAF6DMA0_BOVIN", "mass": { "chemical_mass": 25672.0, "monoisotopic_mass": 25672.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC43", "type": "recommended", "evidence": [ { "id": "A0AAF6DMA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 43", "type": "recommended", "evidence": [ { "id": "A0AAF6DMA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMA0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0", "locus": { "chromosome": "19", "start_pos": 44427063, "end_pos": 44436404, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005693", "url": "https://www.ensembl.org/id/ENSBTAG00000005693" } ] } } ], "crossref": [ { "id": "A0AAF6DMA0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR037666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31684", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31684", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31684:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31684:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF26091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMA0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPSAVAAATSSERDGGGSGFESWLDGRLEALGVDRAVYGAYILGVLQEEEEEEKLDALQGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQAIATLIEKQAQIVVKPRMVSEEEKQRKAALLAQYADVTDEEEPLTEADEKDDSGATTMSIGSDKSLFRNTNVEDVLNARKLERDTLRDESQRKKEQDKLQRERDKLAKQERKEKEKKRTQRGERKR", "length": 227, "header": "tr|A0AAF6DMA0-1|A0AAF6DMA0_BOVIN Isoform 1 of Coiled-coil domain-containing protein 43 OS=Bos taurus OX=9913 GN=CCDC43 PE=3 SV=1 CANONICAL=A0AAF6DMA0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0/entry", "sequence": { "sequence": "MAAPSAVAAATSSERDGGGSGFESWLDGRLEALGVDRAVYGAYILGVLQEEEEEEKLDALQGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQAIATLIEKQAQIVVKPRMVSEEEKQRKAALLAQYADVTDEEEPLTEADEKDDSGATTMSIGSDKSLFRNTNVEDVLNARKLERDTLRDESQRKKEQDKLQRERDKLAKQERKEKEKKRTQRGERKR", "length": 227, "header": "tr|A0AAF6DMA0-1|A0AAF6DMA0_BOVIN Isoform 1 of Coiled-coil domain-containing protein 43 OS=Bos taurus OX=9913 GN=CCDC43 PE=3 SV=1 CANONICAL=A0AAF6DMA0-1" }, "locus": { "chromosome": "19", "start_pos": 44436353, "end_pos": 44428562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007478.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007478.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007478.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007478.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMA0" }, { "id": "PF26091", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26091" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCDC43 PWI-like", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 89, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMB5-1", "uniprot_ac": "A0AAF6DMB5", "uniprot_id": "A0AAF6DMB5_BOVIN", "mass": { "chemical_mass": 124172.0, "monoisotopic_mass": 124172.0 }, "refseq": {}, "gene_names": [ { "name": "ESYT1", "type": "recommended", "evidence": [ { "id": "A0AAF6DMB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ] } ], "protein_names": [ { "name": "Extended synaptotagmin-1", "type": "recommended", "evidence": [ { "id": "A0AAF6DMB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5#function" }, { "database": "UniProtKB", "id": "ARBA00093357", "url": "https://www.uniprot.org/uniprotkb/ARBA00093357#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ESYT1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5", "locus": { "chromosome": "5", "start_pos": 57179946, "end_pos": 57194004, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009543", "url": "https://www.ensembl.org/id/ENSBTAG00000009543" } ] } } ], "crossref": [ { "id": "A0AAF6DMB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04050", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04050", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08391", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08391", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21679", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21679", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45761", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45761", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45761:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45761:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPSLGDSSSSSPSPSPVDQPYPPSEPPDQPTTAHAKPEQSSGDQPAGPGAAGEALAVLTSFGRRLLVLVPVYLAGAMGLSVGFVLFGLALYLGWRRVREEKERSLRVARQLLDDEERLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRILGVKVHTGQSKKQILLDLNISYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLMGDLPIVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQAFCSRVINEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVMDEWFPLQGGQGQVHLRLEWLSLLPDAEKLEQILQWNRGVSSRPEPPSAAILVVYLDRAQDLPMVTSEFSHPQLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEQAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELTLDQWFQLSSSGLNSRLYMKLVMRLLYLDTSEVRFPAMPGIPGAWDLDDSPQTGSSVDVPPRPCHTTPDSSFGTENVLRLHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFHSRVVREDLNPRWNEIFEVIVTSIPGQELEVEVFDKDLDKDDFLGRCKVSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSVYLERAEDLPLRKGTKPPSPYATLAVGDTSHKTKTVPQTATPVWNESASFLIRKPNTESLELQVRGEGSGTLGSLSLPLSELLVADRLCLDRWFTLINGQGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSELELWSGLPQVTSSAPELRQRLTHSDSPPEAPAGPLGQVKLTVWYHSEERKLVGFIHSCRALRQNGRDPPDPYVSLLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWELPLDEALQRKLDVSVKSSSSFMSRERDLLGKVQLDLAEIDLSQGAAQWYDLMDDKDKGSS", "length": 1116, "header": "tr|A0AAF6DMB5-1|A0AAF6DMB5_BOVIN Isoform 1 of Extended synaptotagmin-1 OS=Bos taurus OX=9913 GN=ESYT1 PE=1 SV=1 CANONICAL=A0AAF6DMB5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5/entry", "sequence": { "sequence": "MEPSLGDSSSSSPSPSPVDQPYPPSEPPDQPTTAHAKPEQSSGDQPAGPGAAGEALAVLTSFGRRLLVLVPVYLAGAMGLSVGFVLFGLALYLGWRRVREEKERSLRVARQLLDDEERLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRILGVKVHTGQSKKQILLDLNISYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLMGDLPIVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQAFCSRVINEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVMDEWFPLQGGQGQVHLRLEWLSLLPDAEKLEQILQWNRGVSSRPEPPSAAILVVYLDRAQDLPMVTSEFSHPQLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEQAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELTLDQWFQLSSSGLNSRLYMKLVMRLLYLDTSEVRFPAMPGIPGAWDLDDSPQTGSSVDVPPRPCHTTPDSSFGTENVLRLHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFHSRVVREDLNPRWNEIFEVIVTSIPGQELEVEVFDKDLDKDDFLGRCKVSLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSVYLERAEDLPLRKGTKPPSPYATLAVGDTSHKTKTVPQTATPVWNESASFLIRKPNTESLELQVRGEGSGTLGSLSLPLSELLVADRLCLDRWFTLINGQGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSELELWSGLPQVTSSAPELRQRLTHSDSPPEAPAGPLGQVKLTVWYHSEERKLVGFIHSCRALRQNGRDPPDPYVSLLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWELPLDEALQRKLDVSVKSSSSFMSRERDLLGKVQLDLAEIDLSQGAAQWYDLMDDKDKGSS", "length": 1116, "header": "tr|A0AAF6DMB5-1|A0AAF6DMB5_BOVIN Isoform 1 of Extended synaptotagmin-1 OS=Bos taurus OX=9913 GN=ESYT1 PE=1 SV=1 CANONICAL=A0AAF6DMB5-1" }, "locus": { "chromosome": "5", "start_pos": 57193903, "end_pos": 57180888, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044160.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044160.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041673.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041673.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" }, { "name": "phospholipid transfer activity", "id": "GO:0120014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120014", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum-plasma membrane tethering", "id": "GO:0061817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061817", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 859, "end_pos": 861, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 316, "end_pos": 437, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB5" }, { "id": "PS51847", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51847" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SMP-LTD", "eco_id": "ECO_0000259", "start_pos": 139, "end_pos": 317, "start_aa": "Asp", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 216, "end_pos": 218 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 859, "end_pos": 861 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMB7-1", "uniprot_ac": "A0AAF6DMB7", "uniprot_id": "A0AAF6DMB7_BOVIN", "mass": { "chemical_mass": 16607.0, "monoisotopic_mass": 16607.0 }, "refseq": {}, "gene_names": [ { "name": "SRGN", "type": "recommended", "evidence": [ { "id": "A0AAF6DMB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7" } ] } ], "protein_names": [ { "name": "Serglycin", "type": "synonym", "evidence": [ { "id": "A0AAF6DMB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRGN", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7", "locus": { "chromosome": "28", "start_pos": 25490574, "end_pos": 25474775, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017863", "url": "https://www.ensembl.org/id/ENSBTAG00000017863" } ] } } ], "crossref": [ { "id": "A0AAF6DMB7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF04360", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04360", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TMQVLLQCARLVLALAFILFSSSVQGSPVQRAGYQCNPDSPDSNSANCIEEKGTAFDILRGESSRIPPPRTDISPLMNSKNLNEVFPLSEDISGSGSGAESGSGFLNEIEQEYQPVEENDAFYYTFRSRKRNVPSYNQDLGQDGPEEDFTI", "length": 151, "header": "tr|A0AAF6DMB7-1|A0AAF6DMB7_BOVIN Isoform 1 of Serglycin OS=Bos taurus OX=9913 GN=SRGN PE=4 SV=1 CANONICAL=A0AAF6DMB7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7/entry", "sequence": { "sequence": "TMQVLLQCARLVLALAFILFSSSVQGSPVQRAGYQCNPDSPDSNSANCIEEKGTAFDILRGESSRIPPPRTDISPLMNSKNLNEVFPLSEDISGSGSGAESGSGFLNEIEQEYQPVEENDAFYYTFRSRKRNVPSYNQDLGQDGPEEDFTI", "length": 151, "header": "tr|A0AAF6DMB7-1|A0AAF6DMB7_BOVIN Isoform 1 of Serglycin OS=Bos taurus OX=9913 GN=SRGN PE=4 SV=1 CANONICAL=A0AAF6DMB7-1" }, "locus": { "chromosome": "28", "start_pos": 25489914, "end_pos": 25474828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023743.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023743.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023743.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023743.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of bone mineralization", "id": "GO:0030502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030502", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7" } ], "pmid": "" }, { "name": "granzyme-mediated programmed cell death signaling pathway", "id": "GO:0140507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140507", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMC5-1", "uniprot_ac": "A0AAF6DMC5", "uniprot_id": "A0AAF6DMC5_BOVIN", "mass": { "chemical_mass": 73546.0, "monoisotopic_mass": 73546.0 }, "refseq": {}, "gene_names": [ { "name": "PLXDC1", "type": "recommended", "evidence": [ { "id": "A0AAF6DMC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5" } ] } ], "protein_names": [ { "name": "Plexin domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAF6DMC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLXDC1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5", "locus": { "chromosome": "19", "start_pos": 39590715, "end_pos": 39657775, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019347", "url": "https://www.ensembl.org/id/ENSBTAG00000019347" } ] } } ], "crossref": [ { "id": "A0AAF6DMC5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMC5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13055", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13055", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13055:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13055:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMC5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRGWMVGAQGLRKGRPLSLPGIWPFEPSLHRFPPGSGGGEGRQELRCGVGVADALRGFSQPEGYPPCPPPPPATPSSRLGSGRGSSRGALGQGWEGWGRLGESSGGAAPPPPPRPLPGPRSGRPLGSLAARWRSAALTACLPRAPLPLAAHPSAGQPGGPRRPSRAGTAAGRGRVLASTMRAELWLLVLVLREAARALSPQPGAGQDAGRGSGGATQGTTWGWNRRARESPGPVSELDRTQLSQDLGGGTLAIDKLPDNGTRVVEDNHSYYVSRLYGPSEPRSQELWVDVAKANQSQVKVHRILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVVHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGTVFVVQWDHVYLQGREDRGSFTFQAALHQDGRIVFGYKEIPIPVLEISSSQHPVKAGLSDAFMILNPSPDVPESRRRTIFEYHRVELDPSKVTSTSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWLAYGCAQEAEGRTCEDFQDEDSYSSSPDSSFSPFDGDFTTTSSSLFVDSLTTEDDTKVNPYAGGDGLQNNLAPKTTGSPVHLGTIVGIVLAVLLVASIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRNHPSHSTYTEVEPSGHEKEGFVEAEQC", "length": 680, "header": "tr|A0AAF6DMC5-1|A0AAF6DMC5_BOVIN Isoform 1 of Plexin domain containing 1 OS=Bos taurus OX=9913 GN=PLXDC1 PE=3 SV=1 CANONICAL=A0AAF6DMC5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5/entry", "sequence": { "sequence": "MGRGWMVGAQGLRKGRPLSLPGIWPFEPSLHRFPPGSGGGEGRQELRCGVGVADALRGFSQPEGYPPCPPPPPATPSSRLGSGRGSSRGALGQGWEGWGRLGESSGGAAPPPPPRPLPGPRSGRPLGSLAARWRSAALTACLPRAPLPLAAHPSAGQPGGPRRPSRAGTAAGRGRVLASTMRAELWLLVLVLREAARALSPQPGAGQDAGRGSGGATQGTTWGWNRRARESPGPVSELDRTQLSQDLGGGTLAIDKLPDNGTRVVEDNHSYYVSRLYGPSEPRSQELWVDVAKANQSQVKVHRILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVVHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGTVFVVQWDHVYLQGREDRGSFTFQAALHQDGRIVFGYKEIPIPVLEISSSQHPVKAGLSDAFMILNPSPDVPESRRRTIFEYHRVELDPSKVTSTSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWLAYGCAQEAEGRTCEDFQDEDSYSSSPDSSFSPFDGDFTTTSSSLFVDSLTTEDDTKVNPYAGGDGLQNNLAPKTTGSPVHLGTIVGIVLAVLLVASIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRNHPSHSTYTEVEPSGHEKEGFVEAEQC", "length": 680, "header": "tr|A0AAF6DMC5-1|A0AAF6DMC5_BOVIN Isoform 1 of Plexin domain containing 1 OS=Bos taurus OX=9913 GN=PLXDC1 PE=3 SV=1 CANONICAL=A0AAF6DMC5-1" }, "locus": { "chromosome": "19", "start_pos": 39657766, "end_pos": 39591920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025765.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025765.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025765.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025765.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 75, "start_aa": "Thr", "end_pos": 75, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr75", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 75 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 260, "end_pos": 262 }, { "start_pos": 268, "end_pos": 270 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 501, "end_pos": 503 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMC7-1", "uniprot_ac": "A0AAF6DMC7", "uniprot_id": "A0AAF6DMC7_BOVIN", "mass": { "chemical_mass": 57058.0, "monoisotopic_mass": 57058.0 }, "refseq": { "ac": "XP_005223265", "name": "retinoic acid receptor RXR-beta isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223265" }, "gene_names": [ { "name": "RXRB", "type": "recommended", "evidence": [ { "id": "A0AAF6DMC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ] }, { "name": "RXRB", "type": "synonym", "evidence": [ { "id": "XP_005223265", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223265" } ] } ], "protein_names": [ { "name": "Retinoic acid receptor RXR-gamma", "type": "recommended", "evidence": [ { "id": "A0AAF6DMC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor subfamily 2 group B member 3", "type": "synonym", "evidence": [ { "id": "A0AAF6DMC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7/entry#names_and_taxonomy" } ] }, { "name": "Retinoid X receptor gamma", "type": "synonym", "evidence": [ { "id": "A0AAF6DMC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7/entry#names_and_taxonomy" } ] }, { "name": "retinoic acid receptor RXR-beta isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223265", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223265" } ] } ], "function": [ { "annotation": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7#function" }, { "database": "UniProtKB", "id": "ARBA00037559", "url": "https://www.uniprot.org/uniprotkb/ARBA00037559#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RXRB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7", "locus": { "chromosome": "23", "start_pos": 7380014, "end_pos": 7386725, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000602", "url": "https://www.ensembl.org/id/ENSBTAG00000000602" } ] } } ], "crossref": [ { "id": "A0AAF6DMC7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06943", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06943", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06956", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06956", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504943", "url": "https://www.ncbi.nlm.nih.gov/gene/504943", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005223265", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223265", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAAAGGQQAPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGAAPPSPPGPPLPPSAAASLGGSGAPPPPSMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA", "length": 536, "header": "tr|A0AAF6DMC7-1|A0AAF6DMC7_BOVIN Isoform 1 of Retinoic acid receptor RXR-gamma OS=Bos taurus OX=9913 GN=RXRB PE=3 SV=1 CANONICAL=A0AAF6DMC7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7/entry", "sequence": { "sequence": "MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAAAGGQQAPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGAAPPSPPGPPLPPSAAASLGGSGAPPPPSMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA", "length": 536, "header": "tr|A0AAF6DMC7-1|A0AAF6DMC7_BOVIN Isoform 1 of Retinoic acid receptor RXR-gamma OS=Bos taurus OX=9913 GN=RXRB PE=3 SV=1 CANONICAL=A0AAF6DMC7-1" }, "locus": { "chromosome": "23", "start_pos": 7386546, "end_pos": 7381038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000860.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000860.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000860.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000860.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "nuclear steroid receptor activity", "id": "GO:0003707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003707", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMC7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 532, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC7" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 201, "end_pos": 276, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YR26-1", "uniprot_ac": "A0AAF6YR26", "uniprot_id": "A0AAF6YR26_BOVIN", "mass": { "chemical_mass": 70705.0, "monoisotopic_mass": 70705.0 }, "refseq": {}, "gene_names": [ { "name": "TNFRSF6B", "type": "recommended", "evidence": [ { "id": "A0AAF6YR26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ] } ], "protein_names": [ { "name": "Zinc finger CCCH-type with G patch domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YR26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFRSF6B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26", "locus": {} } ], "crossref": [ { "id": "A0AAF6YR26", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YR26", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10575", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10575", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20384", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20384", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23097:SF116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23097:SF116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46297", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46297", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46297:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46297:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00642", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00642", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DME2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DME2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFU8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPGSRRGTHPSYLVPQRLQLLLPPQVPEHQAGLSHVHSADCREETGPTAACTSCPGHPRSVTDETARTVDRGSSCPHGRSQLKPRPSWLRLASPPLLSARLRLRKCYRIGSALQLWLPRLPSEDPGTQPRRPGKSAPPGRMDEESLQTALRTYDAQLQQVELALGAGLDPSELADLRQLQGDLKELIELTEASLVSVRKSKLLAALDGERPAQEDAEPLALQNAIAETAEVPVAPGAELETVPSRETGPGPTERGQEEDDGEDEEGGAALSGRKVNAPYYSAWGTLEYHNAMIVGTEEADDGSPGVRVLYLYPTHKSLKPCSFFLEGKCRFQENCRFSHGQVVSVDELRPFQDPDLSSLQAGSACLAKRQDGLWYPARITDVDSGYYTVKFDSLLLKETVVEGDSILPPLRTEPAGSSDSDGSDADDPSYARVVEPGAANPGTCSSAFAGWEVHTRGIGSRLLAKMGYEFGKGLGRHAEGRVEPVHAVVLPRGKSLDQCAEILQKRTRAGQAGVSKPPKCRSRGSGPGGRPPPRSVFDFLNEKLKGGAPGAPEVGAAPPGRSGKEVYHASRSTKRALSLRLLQTEEKIEQTQRAIRGIQEALARNAGRHSVTTAQLQEKLAGAQQQLGQLRAQEAGLQREQRKADTHKKMTEF", "length": 654, "header": "tr|A0AAF6YR26-1|A0AAF6YR26_BOVIN Isoform 1 of Zinc finger CCCH-type with G patch domain-containing protein OS=Bos taurus OX=9913 GN=TNFRSF6B PE=4 SV=1 CANONICAL=A0AAF6YR26-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DME2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME2/entry", "sequence": { "sequence": "MRAPPWPVTALLLALASRGAAASAPTYPWRDAETGEWLVCDQCPPGTFVQRPCGRNSPTTCGACPPRHYTQFWNYLERCRYCNVICGEREEEARPCGATHNRACRCRSGFFEHAGFCLEHASCPPGAGVAAPGTPSQNTQCQPCPPGTFSASSSSSERCQPHRNCTALGLAVNVPGSPLHDALCTNCTSFQLGLLEPGAPGTEECEHAVVDFVAFQDISLKRLQRLQQALADPGTQRPPPPLREGRAALQRRLWQQLMELREARPGALGVRLLRALRAARLPGLERSIREHFLRARDCSSSCPPKSQNIRRAFPTSTVPTAEKRQVRLQF", "length": 330, "header": "tr|A0AAF6DME2-1|A0AAF6YR26_BOVIN Computationally mapped isoform of Zinc finger CCCH-type with G patch domain-containing protein OS=Bos taurus OX=9913 GN=TNFRSF6B PE=4 SV=1 CANONICAL=A0AAF6YR26-1" }, "locus": { "chromosome": "13", "start_pos": 54055800, "end_pos": 54048532, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028109.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028109.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028109.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028109.5" } ] } }, { "isoform_ac": "A0AAF6YR26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26/entry", "sequence": { "sequence": "MVPGSRRGTHPSYLVPQRLQLLLPPQVPEHQAGLSHVHSADCREETGPTAACTSCPGHPRSVTDETARTVDRGSSCPHGRSQLKPRPSWLRLASPPLLSARLRLRKCYRIGSALQLWLPRLPSEDPGTQPRRPGKSAPPGRMDEESLQTALRTYDAQLQQVELALGAGLDPSELADLRQLQGDLKELIELTEASLVSVRKSKLLAALDGERPAQEDAEPLALQNAIAETAEVPVAPGAELETVPSRETGPGPTERGQEEDDGEDEEGGAALSGRKVNAPYYSAWGTLEYHNAMIVGTEEADDGSPGVRVLYLYPTHKSLKPCSFFLEGKCRFQENCRFSHGQVVSVDELRPFQDPDLSSLQAGSACLAKRQDGLWYPARITDVDSGYYTVKFDSLLLKETVVEGDSILPPLRTEPAGSSDSDGSDADDPSYARVVEPGAANPGTCSSAFAGWEVHTRGIGSRLLAKMGYEFGKGLGRHAEGRVEPVHAVVLPRGKSLDQCAEILQKRTRAGQAGVSKPPKCRSRGSGPGGRPPPRSVFDFLNEKLKGGAPGAPEVGAAPPGRSGKEVYHASRSTKRALSLRLLQTEEKIEQTQRAIRGIQEALARNAGRHSVTTAQLQEKLAGAQQQLGQLRAQEAGLQREQRKADTHKKMTEF", "length": 654, "header": "tr|A0AAF6YR26-1|A0AAF6YR26_BOVIN Isoform 1 of Zinc finger CCCH-type with G patch domain-containing protein OS=Bos taurus OX=9913 GN=TNFRSF6B PE=4 SV=1 CANONICAL=A0AAF6YR26-1" }, "locus": { "chromosome": "13", "start_pos": 54048685, "end_pos": 54037699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009860.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009860.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009860.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009860.7" } ] } }, { "isoform_ac": "A0AAF6ZFU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU8/entry", "sequence": { "sequence": "RMDEESLQTALRTYDAQLQQVELALGAGLDPSELADLRQLQGDLKELIELTEASLVSVRKSKLLAALDGERPAQEDAEPLALQNAIAETAEVPVAPGAELETVPSRETGPGPTERGQEEDDGEDEEGGAALSGRKVNAPYYSAWGTLEYHNAMIVGTEEADDGSPGVRVLYLYPTHKSLKPCSFFLEGKCRFQENCRFSHGQVVSVDELRPFQDPDLSSLQAGSACLAKRQDGLWYPARITDVDSGYYTVKFDSLLLKETVVEGDSILPPLRTEPAGSSDSDGSDADDPSYARVVEPGAANPGTCSSAFAGWEVHTRGIGSRLLAKMGYEFGKGLGRHAEGRVEPVHAVVLPRGKSLDQCAEILQKRTRAGQAGVSKPPKCRSRGSGPGGRPPPRSVFDFLNEKLKGGAPGAPEVGAAPPGRSGKEVYHASRSTKRALSLRLLQTEEKIEQTQRAIRGIQEALARNAGRHSVTTAQLQEKLAGAQQQLGQLRAQEAGLQREQRKADTHKKMTEF", "length": 514, "header": "tr|A0AAF6ZFU8-1|A0AAF6ZFU8_BOVIN Computationally mapped isoform of Zinc finger CCCH-type with G patch domain-containing protein OS=Bos taurus OX=9913 GN=TNFRSF6B PE=4 SV=1 CANONICAL=A0AAF6YR26-1" }, "locus": { "chromosome": "13", "start_pos": 54046783, "end_pos": 54037699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045200.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045200.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042610.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042610.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 253, "start_aa": "Thr", "end_pos": 253, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr253", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 49, "start_aa": "Thr", "end_pos": 49, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YR26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" }, { "id": "PS50103", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50103" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C3H1-type", "eco_id": "ECO_0000259", "start_pos": 317, "end_pos": 343, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YR26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR26" }, { "id": "PS50174", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000259", "start_pos": 456, "end_pos": 502, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 49, 253 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMF2-1", "uniprot_ac": "A0AAF6DMF2", "uniprot_id": "A0AAF6DMF2_BOVIN", "mass": { "chemical_mass": 28115.0, "monoisotopic_mass": 28115.0 }, "refseq": {}, "gene_names": [ { "name": "LOC786948", "type": "recommended", "evidence": [ { "id": "A0AAF6DMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2" } ] } ], "protein_names": [ { "name": "tryptase", "type": "recommended", "evidence": [ { "id": "A0AAF6DMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.59", "type": "synonym", "evidence": [ { "id": "A0AAF6DMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2#function" }, { "database": "UniProtKB", "id": "ARBA00054350", "url": "https://www.uniprot.org/uniprotkb/ARBA00054350#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC786948", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2", "locus": {} } ], "crossref": [ { "id": "A0AAF6DMF2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253:SF144", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253:SF144", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QALQRAGIVGGQEAPGSRWPWQVSLRVSRRYWRHHCGGSLIHPQWVLTAAHCVGPEVHGPSYFRVQLREQHLYYQDQLLPISRIIPHPNYYSVKNGADIALLELDKLVNISWHVQPVTLPPESETFPPGTQCWVTGWGNVDNGRRLPPPFPLKQVKVPVVENSVCDRKYHSGLSTGDNVPIVREDMLCAGDSGRNFCQGDSGGPLVCKVNGTWLQAGVVSWGDGCAKPNRPGIYTRVTSYLDWIHQYVPQGP", "length": 252, "header": "tr|A0AAF6DMF2-1|A0AAF6DMF2_BOVIN Isoform 1 of tryptase OS=Bos taurus OX=9913 GN=LOC786948 PE=4 SV=1 CANONICAL=A0AAF6DMF2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2/entry", "sequence": { "sequence": "QALQRAGIVGGQEAPGSRWPWQVSLRVSRRYWRHHCGGSLIHPQWVLTAAHCVGPEVHGPSYFRVQLREQHLYYQDQLLPISRIIPHPNYYSVKNGADIALLELDKLVNISWHVQPVTLPPESETFPPGTQCWVTGWGNVDNGRRLPPPFPLKQVKVPVVENSVCDRKYHSGLSTGDNVPIVREDMLCAGDSGRNFCQGDSGGPLVCKVNGTWLQAGVVSWGDGCAKPNRPGIYTRVTSYLDWIHQYVPQGP", "length": 252, "header": "tr|A0AAF6DMF2-1|A0AAF6DMF2_BOVIN Isoform 1 of tryptase OS=Bos taurus OX=9913 GN=LOC786948 PE=4 SV=1 CANONICAL=A0AAF6DMF2-1" }, "locus": { "chromosome": "25", "start_pos": 991878, "end_pos": 990817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009636.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009636.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009636.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009636.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF2" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 249, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.59", "ec_name": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.", "evidence": [ { "id": "3.4.21.59", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.59" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 210, "end_pos": 212 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMF6-1", "uniprot_ac": "A0AAF6DMF6", "uniprot_id": "A0AAF6DMF6_BOVIN", "mass": { "chemical_mass": 13740.0, "monoisotopic_mass": 13740.0 }, "refseq": {}, "gene_names": [ { "name": "PTI", "type": "recommended", "evidence": [ { "id": "A0AAF6DMF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6" } ] } ], "protein_names": [ { "name": "Pancreatic trypsin inhibitor", "type": "synonym", "evidence": [ { "id": "A0AAF6DMF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTI", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6", "locus": {} } ], "crossref": [ { "id": "A0AAF6DMF6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22592", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22592", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10083:SF367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10083:SF367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSSALLKLLLLALQPPYTKVSQNPAMKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARMIRYFYNAKAGLCQPFVYGGCRAKRNNFKSSEDCMRTCGGAIGPWENL", "length": 126, "header": "tr|A0AAF6DMF6-1|A0AAF6DMF6_BOVIN Isoform 1 of Pancreatic trypsin inhibitor OS=Bos taurus OX=9913 GN=PTI PE=4 SV=1 CANONICAL=A0AAF6DMF6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6/entry", "sequence": { "sequence": "MQSSALLKLLLLALQPPYTKVSQNPAMKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARMIRYFYNAKAGLCQPFVYGGCRAKRNNFKSSEDCMRTCGGAIGPWENL", "length": 126, "header": "tr|A0AAF6DMF6-1|A0AAF6DMF6_BOVIN Isoform 1 of Pancreatic trypsin inhibitor OS=Bos taurus OX=9913 GN=PTI PE=4 SV=1 CANONICAL=A0AAF6DMF6-1" }, "locus": { "chromosome": "13", "start_pos": 74300283, "end_pos": 74244077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023042.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023042.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023042.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023042.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF6" }, { "id": "PS50279", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50279" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BPTI/Kunitz inhibitor", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 116, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMH4-1", "uniprot_ac": "A0AAF6DMH4", "uniprot_id": "A0AAF6DMH4_BOVIN", "mass": { "chemical_mass": 51127.0, "monoisotopic_mass": 51127.0 }, "refseq": {}, "gene_names": [ { "name": "LANCL2", "type": "recommended", "evidence": [ { "id": "A0AAF6DMH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ] } ], "protein_names": [ { "name": "LanC-like protein 2", "type": "recommended", "evidence": [ { "id": "A0AAF6DMH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4/entry#names_and_taxonomy" } ] }, { "name": "Testis-specific adriamycin sensitivity protein", "type": "synonym", "evidence": [ { "id": "A0AAF6DMH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4#function" }, { "database": "UniProtKB", "id": "ARBA00054156", "url": "https://www.uniprot.org/uniprotkb/ARBA00054156#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LANCL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4", "locus": { "chromosome": "22", "start_pos": 717681, "end_pos": 801766, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018026", "url": "https://www.ensembl.org/id/ENSBTAG00000018026" } ] } } ], "crossref": [ { "id": "A0AAF6DMH4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04794", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04794", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12736:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12736:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGETMSRRLKLQLGGDADMEDRAFPNPFPDYEAAAERQAEEPPCSRTPLSPEELGLPFHSDGKIINNFTRRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQSYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVVYHKLKSDCESQECITKLLQLQRTIVCRDSDLPDELLYGRAGYLYALLYVNTEIGPGAVCESAIKEVVNAIIESGKALSKEEKKVERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYMRHKRFRSGNYPSSLSNETDRLVHWCHGAPGVIHVLMQAHKVFKEEKYLKDAVECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYHITQDKKYLYRACKFAEWCLEYGAHGCRIPDRPYSLFEGMAGTIHFLSDILAPEASRFPAFELSSSQRDTKVQKD", "length": 451, "header": "tr|A0AAF6DMH4-1|A0AAF6DMH4_BOVIN Isoform 1 of LanC-like protein 2 OS=Bos taurus OX=9913 GN=LANCL2 PE=3 SV=1 CANONICAL=A0AAF6DMH4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4/entry", "sequence": { "sequence": "MGETMSRRLKLQLGGDADMEDRAFPNPFPDYEAAAERQAEEPPCSRTPLSPEELGLPFHSDGKIINNFTRRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQSYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVVYHKLKSDCESQECITKLLQLQRTIVCRDSDLPDELLYGRAGYLYALLYVNTEIGPGAVCESAIKEVVNAIIESGKALSKEEKKVERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYMRHKRFRSGNYPSSLSNETDRLVHWCHGAPGVIHVLMQAHKVFKEEKYLKDAVECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYHITQDKKYLYRACKFAEWCLEYGAHGCRIPDRPYSLFEGMAGTIHFLSDILAPEASRFPAFELSSSQRDTKVQKD", "length": 451, "header": "tr|A0AAF6DMH4-1|A0AAF6DMH4_BOVIN Isoform 1 of LanC-like protein 2 OS=Bos taurus OX=9913 GN=LANCL2 PE=3 SV=1 CANONICAL=A0AAF6DMH4-1" }, "locus": { "chromosome": "22", "start_pos": 801567, "end_pos": 717884, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023996.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023996.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023996.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023996.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "phosphatidylinositol-4-phosphate binding", "id": "GO:0070273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070273", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "positive regulation of abscisic acid-activated signaling pathway", "id": "GO:0009789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" }, { "name": "peptide modification", "id": "GO:0031179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031179", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAF6DMH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" }, { "id": "PIRSR607822-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR607822-1" } ], "binding_site_uniprot": 316, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 316, "end_pos": 316, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" }, { "id": "PIRSR607822-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR607822-1" } ], "binding_site_uniprot": 362, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 362, "end_pos": 362, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH4" }, { "id": "PIRSR607822-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR607822-1" } ], "binding_site_uniprot": 363, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 363, "end_pos": 363, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMI1-1", "uniprot_ac": "A0AAF6DMI1", "uniprot_id": "A0AAF6DMI1_BOVIN", "mass": { "chemical_mass": 63014.0, "monoisotopic_mass": 63014.0 }, "refseq": {}, "gene_names": [ { "name": "RBM45", "type": "recommended", "evidence": [ { "id": "A0AAF6DMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ] } ], "protein_names": [ { "name": "RNA-binding protein 45", "type": "recommended", "evidence": [ { "id": "A0AAF6DMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1/entry#names_and_taxonomy" } ] }, { "name": "Developmentally-regulated RNA-binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6DMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 45", "type": "synonym", "evidence": [ { "id": "A0AAF6DMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1#function" }, { "database": "UniProtKB", "id": "ARBA00057759", "url": "https://www.uniprot.org/uniprotkb/ARBA00057759#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM45", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1", "locus": { "chromosome": "2", "start_pos": 18762125, "end_pos": 18779694, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006168", "url": "https://www.ensembl.org/id/ENSBTAG00000006168" } ] } } ], "crossref": [ { "id": "A0AAF6DMI1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12366", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12366", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12367", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12367", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12368", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12368", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12369", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12369", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPGSHTLSVGLGSTGLGAWTAAGSPGPLGRAAGCPPPPTPEAVSLRVRPAPGAKLFSLPETDPGPATAGCGATVVAVARLEPGGVKGCEPGFRPGWSTMDEAGSCASGGGFRPGVDNLDEPPNSRIFLVISKYTSESVLRERFSPFGEIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCLTPSDTKPIKVFIAQSRSSGSHRDVEDEELTRIFVMIPKSYTEEDLREKFKVFGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSYRAILAEPKNKASESSEQDYYSNMRQETLGHEPRVNMFSFEQQSEFSSFDKNDNRGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASIVWNNPSQQQFLQFAGSSGSQLPQIQTDVALPSCKKKAPPDTPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVSGKNVGYAKYADRLSANDAITTLHGKILNGVRLKVMLADSPREESNKRQRTY", "length": 573, "header": "tr|A0AAF6DMI1-1|A0AAF6DMI1_BOVIN Isoform 1 of RNA-binding protein 45 OS=Bos taurus OX=9913 GN=RBM45 PE=4 SV=1 CANONICAL=A0AAF6DMI1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1/entry", "sequence": { "sequence": "MEPGSHTLSVGLGSTGLGAWTAAGSPGPLGRAAGCPPPPTPEAVSLRVRPAPGAKLFSLPETDPGPATAGCGATVVAVARLEPGGVKGCEPGFRPGWSTMDEAGSCASGGGFRPGVDNLDEPPNSRIFLVISKYTSESVLRERFSPFGEIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCLTPSDTKPIKVFIAQSRSSGSHRDVEDEELTRIFVMIPKSYTEEDLREKFKVFGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSYRAILAEPKNKASESSEQDYYSNMRQETLGHEPRVNMFSFEQQSEFSSFDKNDNRGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASIVWNNPSQQQFLQFAGSSGSQLPQIQTDVALPSCKKKAPPDTPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVSGKNVGYAKYADRLSANDAITTLHGKILNGVRLKVMLADSPREESNKRQRTY", "length": 573, "header": "tr|A0AAF6DMI1-1|A0AAF6DMI1_BOVIN Isoform 1 of RNA-binding protein 45 OS=Bos taurus OX=9913 GN=RBM45 PE=4 SV=1 CANONICAL=A0AAF6DMI1-1" }, "locus": { "chromosome": "2", "start_pos": 18779495, "end_pos": 18765480, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008111.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008111.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008111.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008111.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 40, "start_aa": "Thr", "end_pos": 40, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr40", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI1" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 205, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 40 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 424, "end_pos": 426 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMI5-1", "uniprot_ac": "A0AAF6DMI5", "uniprot_id": "A0AAF6DMI5_BOVIN", "mass": { "chemical_mass": 88072.0, "monoisotopic_mass": 88072.0 }, "refseq": { "ac": "NP_001416395", "name": "tetratricopeptide repeat protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416395" }, "gene_names": [ { "name": "TTC14", "type": "recommended", "evidence": [ { "id": "A0AAF6DMI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5" } ] }, { "name": "TTC14", "type": "synonym", "evidence": [ { "id": "NP_001416395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416395" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 14", "type": "synonym", "evidence": [ { "id": "A0AAF6DMI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 14", "type": "synonym", "evidence": [ { "id": "NP_001416395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416395" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5", "locus": { "chromosome": "1", "start_pos": 86372984, "end_pos": 86382674, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001968", "url": "https://www.ensembl.org/id/ENSBTAG00000001968" } ] } } ], "crossref": [ { "id": "A0AAF6DMI5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMI5", "database": "AlphaFoldDB", "categories": [] }, { "id": "512635", "url": "https://www.ncbi.nlm.nih.gov/gene/512635", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23184:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23184:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001416395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416395", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6DMI5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRDLLRQSLNFHGPSLLSLLRSEQQDNPHFRSLLGSVADPARGPPGQQQLPGRKERRVDNIEIQKFISKKADLLFALSWKSDAPTTAEVSEDNDDYYAVMPPLEQFMDIPTMDRRELFFRDIERGDIVIGRISSIREFGFFMVLICLGSGIMRDISHLEITALCPLRDVPSISNHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYSSSLPPHLSGIKLGVISSEELPLYYRKSVELNSNSLESYENIMQSSLGFVNPGVVEFLLGKLGIDESNPPSLMRGLQSKNFSEEDFASALRKKQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLHVYMQKSLELREKQAEKEEKQKTKKIETSAEKLRKLLKEEKRLKKKRRKSTSSSSVSSADESVSSSSSSSSSGHKRHKKHKRNRSESSRSSKRHSAKASSNQIDQNKKDECFPVPANTSASFLNQKQEVEKLLEKQDRLPYQKKQVKEKDKCSFSSSSVEMPDDFGGRSEDPRDFYDSYKTQAGSSRTEKPYKSERHFSSRRDSSDSFYRSSEDKVKMYGYRRFEKDTEGRKEHYRKWEPGSTRHATSPASSDYSWKSGEKYKKSTYSGSRDLSRHEQRYQLNKNQGEYEREGNYEEDIKTEIPGEGLNSKEHSEGGVKKNLPQNLLNIFNQIAAFEKEKGNKPKN", "length": 771, "header": "tr|A0AAF6DMI5-1|A0AAF6DMI5_BOVIN Isoform 1 of Tetratricopeptide repeat domain 14 OS=Bos taurus OX=9913 GN=TTC14 PE=4 SV=1 CANONICAL=A0AAF6DMI5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5/entry", "sequence": { "sequence": "MDRDLLRQSLNFHGPSLLSLLRSEQQDNPHFRSLLGSVADPARGPPGQQQLPGRKERRVDNIEIQKFISKKADLLFALSWKSDAPTTAEVSEDNDDYYAVMPPLEQFMDIPTMDRRELFFRDIERGDIVIGRISSIREFGFFMVLICLGSGIMRDISHLEITALCPLRDVPSISNHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYSSSLPPHLSGIKLGVISSEELPLYYRKSVELNSNSLESYENIMQSSLGFVNPGVVEFLLGKLGIDESNPPSLMRGLQSKNFSEEDFASALRKKQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLHVYMQKSLELREKQAEKEEKQKTKKIETSAEKLRKLLKEEKRLKKKRRKSTSSSSVSSADESVSSSSSSSSSGHKRHKKHKRNRSESSRSSKRHSAKASSNQIDQNKKDECFPVPANTSASFLNQKQEVEKLLEKQDRLPYQKKQVKEKDKCSFSSSSVEMPDDFGGRSEDPRDFYDSYKTQAGSSRTEKPYKSERHFSSRRDSSDSFYRSSEDKVKMYGYRRFEKDTEGRKEHYRKWEPGSTRHATSPASSDYSWKSGEKYKKSTYSGSRDLSRHEQRYQLNKNQGEYEREGNYEEDIKTEIPGEGLNSKEHSEGGVKKNLPQNLLNIFNQIAAFEKEKGNKPKN", "length": 771, "header": "tr|A0AAF6DMI5-1|A0AAF6DMI5_BOVIN Isoform 1 of Tetratricopeptide repeat domain 14 OS=Bos taurus OX=9913 GN=TTC14 PE=4 SV=1 CANONICAL=A0AAF6DMI5-1" }, "locus": { "chromosome": "1", "start_pos": 86382563, "end_pos": 86373592, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002554.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002554.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002554.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002554.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 542, "end_pos": 544, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI5" }, { "id": "PS50126", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50126" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "S1 motif", "eco_id": "ECO_0000259", "start_pos": 126, "end_pos": 208, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 288, "end_pos": 290 }, { "start_pos": 508, "end_pos": 510 }, { "start_pos": 542, "end_pos": 544 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DMI6-1", "uniprot_ac": "A0AAF6DMI6", "uniprot_id": "A0AAF6DMI6_BOVIN", "mass": { "chemical_mass": 50096.0, "monoisotopic_mass": 50096.0 }, "refseq": {}, "gene_names": [ { "name": "IFT52", "type": "recommended", "evidence": [ { "id": "A0AAF6DMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ] } ], "protein_names": [ { "name": "Intraflagellar transport 52", "type": "synonym", "evidence": [ { "id": "A0AAF6DMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT52", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6", "locus": { "chromosome": "13", "start_pos": 72216743, "end_pos": 72178837, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019606", "url": "https://www.ensembl.org/id/ENSBTAG00000019606" } ] } } ], "crossref": [ { "id": "A0AAF6DMI6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DMI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23683", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23683", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR039975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12969:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12969:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKELRSTILFNAYKKEVFTTSNGYKSMQKRLRSHWKIQSLKDEITPEKLIGVKLWITAGPREKFTAAEFEILKKYLDGGGDILVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYYKYFHPKEALVSNGVLNREISRAAGKAVPGILDEESSGNNAQALTFVYPFGATLSVTKPAVAVLSTGSVCFPLNRPILAFYHSKQNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFRWLTTEDIHLNQIDAEDPEISDYMMLPDTAALSERLRVCLQEGDENPRDFTSLFDLSLYQLDTTSLPKVIKAYEQLNVKHEPLQLIQPQFETPLPALQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTNKLPKDRQDAKHILEHIFFQVVEFKKLNQEHDIDTRHSRTASEDQAS", "length": 441, "header": "tr|A0AAF6DMI6-1|A0AAF6DMI6_BOVIN Isoform 1 of Intraflagellar transport 52 OS=Bos taurus OX=9913 GN=IFT52 PE=4 SV=1 CANONICAL=A0AAF6DMI6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DMI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6/entry", "sequence": { "sequence": "MEKELRSTILFNAYKKEVFTTSNGYKSMQKRLRSHWKIQSLKDEITPEKLIGVKLWITAGPREKFTAAEFEILKKYLDGGGDILVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYYKYFHPKEALVSNGVLNREISRAAGKAVPGILDEESSGNNAQALTFVYPFGATLSVTKPAVAVLSTGSVCFPLNRPILAFYHSKQNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFRWLTTEDIHLNQIDAEDPEISDYMMLPDTAALSERLRVCLQEGDENPRDFTSLFDLSLYQLDTTSLPKVIKAYEQLNVKHEPLQLIQPQFETPLPALQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTNKLPKDRQDAKHILEHIFFQVVEFKKLNQEHDIDTRHSRTASEDQAS", "length": 441, "header": "tr|A0AAF6DMI6-1|A0AAF6DMI6_BOVIN Isoform 1 of Intraflagellar transport 52 OS=Bos taurus OX=9913 GN=IFT52 PE=4 SV=1 CANONICAL=A0AAF6DMI6-1" }, "locus": { "chromosome": "13", "start_pos": 72216548, "end_pos": 72181097, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026122.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026122.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026122.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026122.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "ciliary base", "id": "GO:0097546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "dendrite terminus", "id": "GO:0044292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044292", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "intraciliary transport particle B", "id": "GO:0030992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" }, { "name": "intraciliary anterograde transport", "id": "GO:0035720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035720", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" }, { "id": "PF23355", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23355" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT52 GIFT", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 254, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" }, { "id": "PF23352", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23352" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT52 central", "eco_id": "ECO_0000259", "start_pos": 270, "end_pos": 350, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMI6" }, { "id": "PF21178", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Intraflagellar transport protein 52 C-terminal", "eco_id": "ECO_0000259", "start_pos": 361, "end_pos": 412, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YGJ2-1", "uniprot_ac": "A0AAF6YGJ2", "uniprot_id": "A0AAF6YGJ2_BOVIN", "mass": { "chemical_mass": 16159.0, "monoisotopic_mass": 16159.0 }, "refseq": {}, "gene_names": [ { "name": "VKORC1", "type": "recommended", "evidence": [ { "id": "A0AAF6YGJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ] } ], "protein_names": [ { "name": "vitamin-K-epoxide reductase (warfarin-sensitive)", "type": "recommended", "evidence": [ { "id": "A0AAF6YGJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2/entry#names_and_taxonomy" } ] }, { "name": "1.17.4.4", "type": "synonym", "evidence": [ { "id": "A0AAF6YGJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VKORC1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2", "locus": { "chromosome": "25", "start_pos": 27200500, "end_pos": 27203455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000405", "url": "https://www.ensembl.org/id/ENSBTAG00000000405" } ] } } ], "crossref": [ { "id": "A0AAF6YGJ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YGJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12917", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12917", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR012932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038354", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038354", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14519", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14519", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14519:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14519:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH", "length": 147, "header": "tr|A0AAF6YGJ2-1|A0AAF6YGJ2_BOVIN Isoform 1 of vitamin-K-epoxide reductase (warfarin-sensitive) OS=Bos taurus OX=9913 GN=VKORC1 PE=3 SV=1 CANONICAL=A0AAF6YGJ2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YGJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2/entry", "sequence": { "sequence": "MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH", "length": 147, "header": "tr|A0AAF6YGJ2-1|A0AAF6YGJ2_BOVIN Isoform 1 of vitamin-K-epoxide reductase (warfarin-sensitive) OS=Bos taurus OX=9913 GN=VKORC1 PE=3 SV=1 CANONICAL=A0AAF6YGJ2-1" }, "locus": { "chromosome": "25", "start_pos": 27203256, "end_pos": 27201295, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000519.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000519.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000519.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000519.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "vitamin-K-epoxide reductase (warfarin-sensitive) activity", "id": "GO:0047057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047057", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" }, { "name": "vitamin-K-epoxide reductase (warfarin-insensitive) activity", "id": "GO:0047058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047058", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" }, { "name": "quinone binding", "id": "GO:0048038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048038", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" }, { "name": "vitamin K metabolic process", "id": "GO:0042373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042373", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YGJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGJ2" }, { "id": "SM00756", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00756" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Vitamin K epoxide reductase", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 137, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.17.4.4", "ec_name": "phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol.", "evidence": [ { "id": "1.17.4.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.4" }, { "id": "1.17.4.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.17.4.4" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YGT8-1", "uniprot_ac": "A0AAF6YGT8", "uniprot_id": "A0AAF6YGT8_BOVIN", "mass": { "chemical_mass": 36825.0, "monoisotopic_mass": 36825.0 }, "refseq": {}, "gene_names": [ { "name": "HES1", "type": "recommended", "evidence": [ { "id": "A0AAF6YGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ] } ], "protein_names": [ { "name": "Hes family bHLH transcription factor 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HES1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8", "locus": { "chromosome": "1", "start_pos": 73362145, "end_pos": 73365254, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000569", "url": "https://www.ensembl.org/id/ENSBTAG00000000569" } ] } } ], "crossref": [ { "id": "A0AAF6YGT8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YGT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11459", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11459", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTGESGSPRPPLRASLSPRGDFFQTSARGCERHSATFYCLGSLLRSHGLGLIYSHNSKLLLFRKGRERAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSPAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN", "length": 346, "header": "tr|A0AAF6YGT8-1|A0AAF6YGT8_BOVIN Isoform 1 of Hes family bHLH transcription factor 1 OS=Bos taurus OX=9913 GN=HES1 PE=4 SV=1 CANONICAL=A0AAF6YGT8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YGT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8/entry", "sequence": { "sequence": "MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTGESGSPRPPLRASLSPRGDFFQTSARGCERHSATFYCLGSLLRSHGLGLIYSHNSKLLLFRKGRERAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSPAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN", "length": 346, "header": "tr|A0AAF6YGT8-1|A0AAF6YGT8_BOVIN Isoform 1 of Hes family bHLH transcription factor 1 OS=Bos taurus OX=9913 GN=HES1 PE=4 SV=1 CANONICAL=A0AAF6YGT8-1" }, "locus": { "chromosome": "1", "start_pos": 73365032, "end_pos": 73363149, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000742.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000742.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000742.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000742.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 17, "start_aa": "Thr", "end_pos": 17, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 27, "go_terms": [ { "name": "negative regulation of inner ear receptor cell differentiation", "id": "GO:2000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "positive regulation of Notch signaling pathway", "id": "GO:0045747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045747", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "negative regulation of glial cell proliferation", "id": "GO:0060253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060253", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "embryonic heart tube morphogenesis", "id": "GO:0003143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003143", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "positive regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046427", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "ventricular septum morphogenesis", "id": "GO:0060412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell development", "id": "GO:0097084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097084", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "labyrinthine layer blood vessel development", "id": "GO:0060716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060716", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "glomerulus vasculature development", "id": "GO:0072012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072012", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "neuronal stem cell population maintenance", "id": "GO:0097150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097150", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "positive regulation of astrocyte differentiation", "id": "GO:0048711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048711", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "pharyngeal arch artery morphogenesis", "id": "GO:0061626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061626", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "negative regulation of stem cell differentiation", "id": "GO:2000737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "negative regulation of oligodendrocyte differentiation", "id": "GO:0048715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048715", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "ascending aorta morphogenesis", "id": "GO:0035910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035910", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle, embryonic", "id": "GO:0045977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045977", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "ureteric bud morphogenesis", "id": "GO:0060675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060675", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "comma-shaped body morphogenesis", "id": "GO:0072049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072049", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "S-shaped body morphogenesis", "id": "GO:0072050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072050", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "renal interstitial fibroblast development", "id": "GO:0072141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072141", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "metanephric nephron tubule morphogenesis", "id": "GO:0072282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072282", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "negative regulation of pro-B cell differentiation", "id": "GO:2000974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000974", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "HLH domain binding", "id": "GO:0043398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043398", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" }, { "name": "N-box binding", "id": "GO:0071820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071820", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 91, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGT8" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 209, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 17 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YGY4-1", "uniprot_ac": "A0AAF6YGY4", "uniprot_id": "A0AAF6YGY4_BOVIN", "mass": { "chemical_mass": 27015.0, "monoisotopic_mass": 27015.0 }, "refseq": {}, "gene_names": [ { "name": "SDF2L1", "type": "recommended", "evidence": [ { "id": "A0AAF6YGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ] } ], "protein_names": [ { "name": "Stromal cell derived factor 2 like 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDF2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4", "locus": { "chromosome": "17", "start_pos": 72112698, "end_pos": 72114897, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000067", "url": "https://www.ensembl.org/id/ENSBTAG00000000067" } ] } } ], "crossref": [ { "id": "A0AAF6YGY4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YGY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR016093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46809", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46809", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46809:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46809:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEAERRAGRRLAAAAGPVRVRIGRRRRRKRPRAESPDPGRGDVERGQRSSCGPGAAGYTAGPLAVGGPCRQERRGARDLRVGAEAVQHAAPGSGQQSVTGVEASDDANSYWRIRGGTEGECPRGSPVRCGQAVRLTHVLTGKNLHTHHFPSPLTNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAVRFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMASASAHNKWKAMEGIFIKPSPEAPGGHDEL", "length": 252, "header": "tr|A0AAF6YGY4-1|A0AAF6YGY4_BOVIN Isoform 1 of Stromal cell derived factor 2 like 1 OS=Bos taurus OX=9913 GN=SDF2L1 PE=4 SV=1 CANONICAL=A0AAF6YGY4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YGY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4/entry", "sequence": { "sequence": "MAAEAERRAGRRLAAAAGPVRVRIGRRRRRKRPRAESPDPGRGDVERGQRSSCGPGAAGYTAGPLAVGGPCRQERRGARDLRVGAEAVQHAAPGSGQQSVTGVEASDDANSYWRIRGGTEGECPRGSPVRCGQAVRLTHVLTGKNLHTHHFPSPLTNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAVRFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMASASAHNKWKAMEGIFIKPSPEAPGGHDEL", "length": 252, "header": "tr|A0AAF6YGY4-1|A0AAF6YGY4_BOVIN Isoform 1 of Stromal cell derived factor 2 like 1 OS=Bos taurus OX=9913 GN=SDF2L1 PE=4 SV=1 CANONICAL=A0AAF6YGY4-1" }, "locus": { "chromosome": "17", "start_pos": 72114698, "end_pos": 72112826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000074.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000074.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000074.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000074.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum chaperone complex", "id": "GO:0034663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034663", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ], "pmid": "" }, { "name": "protein folding chaperone complex", "id": "GO:0101031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein refolding", "id": "GO:0042026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGY4" }, { "id": "PS50919", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50919" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIR", "eco_id": "ECO_0000259", "start_pos": 126, "end_pos": 181, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YH10-1", "uniprot_ac": "A0AAF6YH10", "uniprot_id": "A0AAF6YH10_BOVIN", "mass": { "chemical_mass": 21511.0, "monoisotopic_mass": 21511.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Prepronociceptin", "type": "synonym", "evidence": [ { "id": "A0AAF6YH10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10", "locus": {} } ], "crossref": [ { "id": "A0AAF6YH10", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YH10", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11438", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11438", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11438:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11438:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRLVVWTRGGRCQERQKLPGFLESWQMCILECEEKAFTSPLWTPCTKVMARGSWQLSPADPDHVAAALDQPRASEMQHLKRMPRVRSLFQRQKRTEPGLEEVGEIEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGVRAIPKAACLQPQTCRLGIRTPPSPRH", "length": 186, "header": "tr|A0AAF6YH10-1|A0AAF6YH10_BOVIN Isoform 1 of Prepronociceptin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YH10-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YH10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10/entry", "sequence": { "sequence": "MVRLVVWTRGGRCQERQKLPGFLESWQMCILECEEKAFTSPLWTPCTKVMARGSWQLSPADPDHVAAALDQPRASEMQHLKRMPRVRSLFQRQKRTEPGLEEVGEIEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGVRAIPKAACLQPQTCRLGIRTPPSPRH", "length": 186, "header": "tr|A0AAF6YH10-1|A0AAF6YH10_BOVIN Isoform 1 of Prepronociceptin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YH10-1" }, "locus": { "chromosome": "8", "start_pos": 10392725, "end_pos": 10386471, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000695.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000695.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000695.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000695.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "pmid": "" }, { "name": "sensory perception of pain", "id": "GO:0019233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019233", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "pmid": "" }, { "name": "neuron-neuron synaptic transmission", "id": "GO:0007270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YH25-1", "uniprot_ac": "A0AAF6YH25", "uniprot_id": "A0AAF6YH25_BOVIN", "mass": { "chemical_mass": 72372.0, "monoisotopic_mass": 72372.0 }, "refseq": {}, "gene_names": [ { "name": "ABCF2", "type": "recommended", "evidence": [ { "id": "A0AAF6YH25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25" } ] } ], "protein_names": [ { "name": "ATP-binding cassette sub-family F member 2", "type": "recommended", "evidence": [ { "id": "A0AAF6YH25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25", "locus": { "chromosome": "4", "start_pos": 113788362, "end_pos": 113803182, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000607", "url": "https://www.ensembl.org/id/ENSBTAG00000000607" } ] } } ], "crossref": [ { "id": "A0AAF6YH25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YH25", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03221", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03221", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19211", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19211", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19211:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19211:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12848", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12848", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YH25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAITEPQVAEERNEEANGRETTDCFSFLSPEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDAHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAERLAHEDAECEKLLELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVGEEPQPTRRTHNV", "length": 633, "header": "tr|A0AAF6YH25-1|A0AAF6YH25_BOVIN Isoform 1 of ATP-binding cassette sub-family F member 2 OS=Bos taurus OX=9913 GN=ABCF2 PE=3 SV=1 CANONICAL=A0AAF6YH25-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YH25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25/entry", "sequence": { "sequence": "MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDAITEPQVAEERNEEANGRETTDCFSFLSPEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDAHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLQCVMEVDTERAMLEREAERLAHEDAECEKLLELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINDFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVGEEPQPTRRTHNV", "length": 633, "header": "tr|A0AAF6YH25-1|A0AAF6YH25_BOVIN Isoform 1 of ATP-binding cassette sub-family F member 2 OS=Bos taurus OX=9913 GN=ABCF2 PE=3 SV=1 CANONICAL=A0AAF6YH25-1" }, "locus": { "chromosome": "4", "start_pos": 113802275, "end_pos": 113788850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000799.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000799.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000799.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000799.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YH25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH25" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 335, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 410, "end_pos": 412 }, { "start_pos": 526, "end_pos": 528 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YH95-1", "uniprot_ac": "A0AAF6YH95", "uniprot_id": "A0AAF6YH95_BOVIN", "mass": { "chemical_mass": 28051.0, "monoisotopic_mass": 28051.0 }, "refseq": {}, "gene_names": [ { "name": "MRPS26", "type": "recommended", "evidence": [ { "id": "A0AAF6YH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein mS26", "type": "recommended", "evidence": [ { "id": "A0AAF6YH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95/entry#names_and_taxonomy" } ] }, { "name": "28S ribosomal protein S26, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAF6YH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH95", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPS26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95", "locus": { "chromosome": "13", "start_pos": 52129509, "end_pos": 52131975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000825", "url": "https://www.ensembl.org/id/ENSBTAG00000000825" } ] } } ], "crossref": [ { "id": "A0AAF6YH95", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YH95", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21035:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21035:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14943", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14943", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YH95", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPAQGGSKTVGSTGLGRSPRTTRPVVPRGHFRVPMIPCGVPEAGPSRHAARAEHPWRAALGPPSCPVSAPRARPKNPPRSAGQVQDRARGDPARRGSCGILRADRALPAVPPDGARPQEFVTEVRRKVHEARAGVLAERKALQDAAEHRELMAWNQAENQRLHELRMARLRQEAREQEQWQAEEAAREAREAEAWARLKEQEVLQLQEDAKNFITRENLEARVEEALDSPKSYNWAVTREGQVVTPQHKGS", "length": 252, "header": "tr|A0AAF6YH95-1|A0AAF6YH95_BOVIN Isoform 1 of Small ribosomal subunit protein mS26 OS=Bos taurus OX=9913 GN=MRPS26 PE=3 SV=1 CANONICAL=A0AAF6YH95-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YH95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95/entry", "sequence": { "sequence": "MFPAQGGSKTVGSTGLGRSPRTTRPVVPRGHFRVPMIPCGVPEAGPSRHAARAEHPWRAALGPPSCPVSAPRARPKNPPRSAGQVQDRARGDPARRGSCGILRADRALPAVPPDGARPQEFVTEVRRKVHEARAGVLAERKALQDAAEHRELMAWNQAENQRLHELRMARLRQEAREQEQWQAEEAAREAREAEAWARLKEQEVLQLQEDAKNFITRENLEARVEEALDSPKSYNWAVTREGQVVTPQHKGS", "length": 252, "header": "tr|A0AAF6YH95-1|A0AAF6YH95_BOVIN Isoform 1 of Small ribosomal subunit protein mS26 OS=Bos taurus OX=9913 GN=MRPS26 PE=3 SV=1 CANONICAL=A0AAF6YH95-1" }, "locus": { "chromosome": "13", "start_pos": 52131916, "end_pos": 52129604, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001091.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001091.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001091.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001091.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial small ribosomal subunit", "id": "GO:0005763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005763", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YH95", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH95" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YHE7-1", "uniprot_ac": "A0AAF6YHE7", "uniprot_id": "A0AAF6YHE7_BOVIN", "mass": { "chemical_mass": 56029.0, "monoisotopic_mass": 56029.0 }, "refseq": {}, "gene_names": [ { "name": "TUBB3", "type": "recommended", "evidence": [ { "id": "A0AAF6YHE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ] } ], "protein_names": [ { "name": "Tubulin beta chain", "type": "recommended", "evidence": [ { "id": "A0AAF6YHE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7#function" }, { "database": "UniProtKB", "id": "RU000352", "url": "https://www.uniprot.org/uniprotkb/RU000352#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUBB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7", "locus": { "chromosome": "18", "start_pos": 14717351, "end_pos": 14708701, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023730", "url": "https://www.ensembl.org/id/ENSBTAG00000023730" } ] } } ], "crossref": [ { "id": "A0AAF6YHE7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YHE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02187", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02187", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLAAAGAAVFGGAPGLAARDDAVPGETGGAPPIRAGGGGGRASAASCSRSARVSQPPAIAPSMREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK", "length": 512, "header": "tr|A0AAF6YHE7-1|A0AAF6YHE7_BOVIN Isoform 1 of Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB3 PE=3 SV=1 CANONICAL=A0AAF6YHE7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YHE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7/entry", "sequence": { "sequence": "MLAAAGAAVFGGAPGLAARDDAVPGETGGAPPIRAGGGGGRASAASCSRSARVSQPPAIAPSMREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK", "length": 512, "header": "tr|A0AAF6YHE7-1|A0AAF6YHE7_BOVIN Isoform 1 of Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB3 PE=3 SV=1 CANONICAL=A0AAF6YHE7-1" }, "locus": { "chromosome": "18", "start_pos": 14717017, "end_pos": 14708900, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000568.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000568.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000568.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000568.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 13, "go_terms": [ { "name": "sperm end piece", "id": "GO:0097229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097229", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "netrin receptor binding", "id": "GO:1990890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990890", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" }, { "name": "dorsal root ganglion development", "id": "GO:1990791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990791", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YHE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" }, { "id": "SM00865", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubulin/FtsZ 2-layer sandwich", "eco_id": "ECO_0000259", "start_pos": 308, "end_pos": 445, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YHE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHE7" }, { "id": "SM00864", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00864" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubulin/FtsZ GTPase", "eco_id": "ECO_0000259", "start_pos": 109, "end_pos": 306, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 246, "end_pos": 248 }, { "start_pos": 399, "end_pos": 401 }, { "start_pos": 432, "end_pos": 434 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YHL8-1", "uniprot_ac": "A0AAF6YHL8", "uniprot_id": "A0AAF6YHL8_BOVIN", "mass": { "chemical_mass": 81398.0, "monoisotopic_mass": 81398.0 }, "refseq": {}, "gene_names": [ { "name": "MAPK7", "type": "recommended", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ], "protein_names": [ { "name": "Mitogen-activated protein kinase", "type": "recommended", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.24", "type": "synonym", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8#function" }, { "database": "UniProtKB", "id": "ARBA00058403", "url": "https://www.uniprot.org/uniprotkb/ARBA00058403#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAPK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8", "locus": { "chromosome": "19", "start_pos": 34085037, "end_pos": 34090250, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001014", "url": "https://www.ensembl.org/id/ENSBTAG00000001014" } ] } } ], "crossref": [ { "id": "A0AAF6YHL8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YHL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07855", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07855", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24055", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24055", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPLKEDDGEDGSGEPPGPVKAEPAGTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARVSAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPLPCPGPAPDTIDLTLQPPPPASEPAPPKKEGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGVSGGPSADPLAGLVLSDNDRSLLERWTRMAQPPAPAPATARPPSPPAGPATQPTGPLPQPACPPPAPAAGPAAPQTTAASGLLAPQPLVPPPGLPGPSALSVLPYFPSGPPPPDPGGAPQPSTSESPDVTLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQTQPRSQPPCSLTGSRATA", "length": 750, "header": "tr|A0AAF6YHL8-1|A0AAF6YHL8_BOVIN Isoform 1 of Mitogen-activated protein kinase OS=Bos taurus OX=9913 GN=MAPK7 PE=3 SV=1 CANONICAL=A0AAF6YHL8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YHL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8/entry", "sequence": { "sequence": "MAEPLKEDDGEDGSGEPPGPVKAEPAGTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARVSAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPLPCPGPAPDTIDLTLQPPPPASEPAPPKKEGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGVSGGPSADPLAGLVLSDNDRSLLERWTRMAQPPAPAPATARPPSPPAGPATQPTGPLPQPACPPPAPAAGPAAPQTTAASGLLAPQPLVPPPGLPGPSALSVLPYFPSGPPPPDPGGAPQPSTSESPDVTLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQTQPRSQPPCSLTGSRATA", "length": 750, "header": "tr|A0AAF6YHL8-1|A0AAF6YHL8_BOVIN Isoform 1 of Mitogen-activated protein kinase OS=Bos taurus OX=9913 GN=MAPK7 PE=3 SV=1 CANONICAL=A0AAF6YHL8-1" }, "locus": { "chromosome": "19", "start_pos": 34089870, "end_pos": 34085603, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001347.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001347.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001347.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001347.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "mitogen-activated protein kinase binding", "id": "GO:0051019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051019", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "MAP kinase activity", "id": "GO:0004707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004707", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "positive regulation of protein metabolic process", "id": "GO:0051247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051247", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell apoptotic process", "id": "GO:2000352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000352", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "negative regulation of heterotypic cell-cell adhesion", "id": "GO:0034115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034115", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "negative regulation of response to cytokine stimulus", "id": "GO:0060761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060761", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway", "id": "GO:1902176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902176", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "id": "GO:2001240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001240", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" }, { "name": "cellular response to laminar fluid shear stress", "id": "GO:0071499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071499", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 717, "end_pos": 719, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 347, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.24", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.24", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24" }, { "id": "2.7.11.24", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.24" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 717, "end_pos": 719 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YHP9-1", "uniprot_ac": "A0AAF6YHP9", "uniprot_id": "A0AAF6YHP9_BOVIN", "mass": { "chemical_mass": 49254.0, "monoisotopic_mass": 49254.0 }, "refseq": { "ac": "XP_024851737", "name": "F-box/WD repeat-containing protein 2 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851737" }, "gene_names": [ { "name": "FBXW2", "type": "recommended", "evidence": [ { "id": "A0AAF6YHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9" } ] }, { "name": "FBXW2", "type": "synonym", "evidence": [ { "id": "XP_024851737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851737" } ] } ], "protein_names": [ { "name": "F-box/WD repeat-containing protein 2", "type": "recommended", "evidence": [ { "id": "A0AAF6YHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9/entry#names_and_taxonomy" } ] }, { "name": "F-box and WD-40 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9/entry#names_and_taxonomy" } ] }, { "name": "F-box/WD repeat-containing protein 2 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024851737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851737" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHP9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9#function" }, { "database": "UniProtKB", "id": "ARBA00003437", "url": "https://www.uniprot.org/uniprotkb/ARBA00003437#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHP9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9", "locus": { "chromosome": "8", "start_pos": 110161751, "end_pos": 110188746, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000712", "url": "https://www.ensembl.org/id/ENSBTAG00000000712" } ] } } ], "crossref": [ { "id": "A0AAF6YHP9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YHP9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22131", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22131", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767863", "url": "https://www.ncbi.nlm.nih.gov/gene/767863", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44436", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44436", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44436:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44436:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851737", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851737", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YHP9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ADU5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ADU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPWKQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKSLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYILDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG", "length": 435, "header": "tr|A0AAF6YHP9-1|A0AAF6YHP9_BOVIN Isoform 1 of F-box/WD repeat-containing protein 2 OS=Bos taurus OX=9913 GN=FBXW2 PE=4 SV=1 CANONICAL=A0AAF6YHP9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YHP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9/entry", "sequence": { "sequence": "MPWKQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKSLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYILDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG", "length": 435, "header": "tr|A0AAF6YHP9-1|A0AAF6YHP9_BOVIN Isoform 1 of F-box/WD repeat-containing protein 2 OS=Bos taurus OX=9913 GN=FBXW2 PE=4 SV=1 CANONICAL=A0AAF6YHP9-1" }, "locus": { "chromosome": "8", "start_pos": 110188242, "end_pos": 110162489, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000956.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000956.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000956.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000956.6" } ] } }, { "isoform_ac": "A0AAF7ADU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADU5/entry", "sequence": { "sequence": "MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKSLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRMEDLTSPTEYRTCAPCSGIAEPSPLDHQEIPCIGLKCLQKRLQQHNRGTVAFMPGSRLLTLILAGSSRLLR", "length": 430, "header": "tr|A0AAF7ADU5-1|A0AAF7ADU5_BOVIN Computationally mapped isoform of F-box and WD repeat domain containing 2 OS=Bos taurus OX=9913 GN=FBXW2 PE=4 SV=1 CANONICAL=A0AAF6YHP9-1" }, "locus": { "chromosome": "8", "start_pos": 110183111, "end_pos": 110162755, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085937.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085937.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067173.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067173.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHP9" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 82, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 411, "end_pos": 413 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YHR7-1", "uniprot_ac": "A0AAF6YHR7", "uniprot_id": "A0AAF6YHR7_BOVIN", "mass": { "chemical_mass": 16342.0, "monoisotopic_mass": 16342.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Aquaporin-1", "type": "recommended", "evidence": [ { "id": "A0AAF6YHR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7/entry#names_and_taxonomy" } ] }, { "name": "Aquaporin-CHIP", "type": "synonym", "evidence": [ { "id": "A0AAF6YHR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7#function" }, { "database": "UniProtKB", "id": "ARBA00049627", "url": "https://www.uniprot.org/uniprotkb/ARBA00049627#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7", "locus": {} } ], "crossref": [ { "id": "A0AAF6YHR7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YHR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19139:SF161", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139:SF161", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29667", "url": "https://www.rhea-db.org/rhea/29667", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29675", "url": "https://www.rhea-db.org/rhea/29675", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "74375", "url": "https://www.rhea-db.org/rhea/74375", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "74891", "url": "https://www.rhea-db.org/rhea/74891", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "74895", "url": "https://www.rhea-db.org/rhea/74895", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GMGWNVQDVRLAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK", "length": 151, "header": "tr|A0AAF6YHR7-1|A0AAF6YHR7_BOVIN Isoform 1 of Aquaporin-1 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YHR7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YHR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7/entry", "sequence": { "sequence": "GMGWNVQDVRLAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK", "length": 151, "header": "tr|A0AAF6YHR7-1|A0AAF6YHR7_BOVIN Isoform 1 of Aquaporin-1 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YHR7-1" }, "locus": { "chromosome": "4", "start_pos": 65437111, "end_pos": 65435490, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000993.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000993.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000993.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000993.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "brush border membrane", "id": "GO:0031526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031526", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "ankyrin-1 complex", "id": "GO:0170014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170014", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "potassium channel activity", "id": "GO:0005267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005267", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "glycerol transmembrane transporter activity", "id": "GO:0015168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015168", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "water channel activity", "id": "GO:0015250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015250", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "intracellularly cGMP-activated cation channel activity", "id": "GO:0005223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005223", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "ammonium channel activity", "id": "GO:0008519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008519", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "nitric oxide transmembrane transporter activity", "id": "GO:0030184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030184", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "carbon dioxide transmembrane transporter activity", "id": "GO:0035379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035379", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "hydrogen peroxide channel activity", "id": "GO:0140070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140070", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to dexamethasone stimulus", "id": "GO:0071549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071549", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "intracellular water homeostasis", "id": "GO:0009992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009992", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "pancreatic juice secretion", "id": "GO:0030157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030157", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "odontogenesis", "id": "GO:0042476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042476", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "positive regulation of fibroblast proliferation", "id": "GO:0048146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048146", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to nitric oxide", "id": "GO:0071732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071732", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "renal water transport", "id": "GO:0003097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003097", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to copper ion", "id": "GO:0071280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071280", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to mercury ion", "id": "GO:0071288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071288", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular hyperosmotic response", "id": "GO:0071474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071474", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "lateral ventricle development", "id": "GO:0021670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021670", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "establishment or maintenance of actin cytoskeleton polarity", "id": "GO:0030950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030950", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cerebrospinal fluid secretion", "id": "GO:0033326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033326", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "transepithelial water transport", "id": "GO:0035377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035377", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "positive regulation of saliva secretion", "id": "GO:0046878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046878", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" }, { "name": "cellular response to salt stress", "id": "GO:0071472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071472", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHR7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29667", "name": "", "equation": "H2O(in) = H2O(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29667", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29667" } ] }, { "id": "29675", "name": "", "equation": "glycerol(in) = glycerol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29675", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29675" } ] }, { "id": "74375", "name": "", "equation": "H2O2(out) = H2O2(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "74375", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/74375" } ] }, { "id": "74891", "name": "", "equation": "CO2(out) = CO2(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "74891", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/74891" } ] }, { "id": "74895", "name": "", "equation": "nitric oxide(out) = nitric oxide(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "74895", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/74895" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YHT9-1", "uniprot_ac": "A0AAF6YHT9", "uniprot_id": "A0AAF6YHT9_BOVIN", "mass": { "chemical_mass": 46945.0, "monoisotopic_mass": 46945.0 }, "refseq": {}, "gene_names": [ { "name": "SERPINB10", "type": "recommended", "evidence": [ { "id": "A0AAF6YHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ] } ], "protein_names": [ { "name": "Serpin B10", "type": "recommended", "evidence": [ { "id": "A0AAF6YHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINB10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9", "locus": { "chromosome": "24", "start_pos": 62123449, "end_pos": 62103465, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001102", "url": "https://www.ensembl.org/id/ENSBTAG00000001102" } ] } } ], "crossref": [ { "id": "A0AAF6YHT9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YHT9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19569", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19569", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF175", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF175", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFLAKSINQFALEFSKKLAESAEGKNIFFSPWGISASLAMVYLGTKGTTAAQMAQVLQFSRDQDSKFCPDSEKKRKMEFNVGKPEEIYSDFQTLISEINSSSHACILKTANRIYGEKTFPFHKKYLEDVKTYFGAEPQSVNFIGASDQIRKEINSWVEKQTEGKILNLLPDDAVDPTTRMVLVNALYFKGVWEHQFLVQNTTEKSFKINKTTSKPVQMMSMKEKLQVFYIESPQAMGLQLYYESRDLSLLILLPEDVDGLDQVKGSVYSYLPPFLSPLLEKTITYEKLSEWTSADMMELCNVQLNLPKFKLEETYDLKSTLSSMGMSDAFNQSKADFSGMSSERNLFLSNVFHKCFVEINEQGTEAAAGTGSEVSVRMKLPSIEFNADHPFLFFIRHNKTNGILFYGRFCSP", "length": 413, "header": "tr|A0AAF6YHT9-1|A0AAF6YHT9_BOVIN Isoform 1 of Serpin B10 OS=Bos taurus OX=9913 GN=SERPINB10 PE=3 SV=1 CANONICAL=A0AAF6YHT9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YHT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9/entry", "sequence": { "sequence": "MDFLAKSINQFALEFSKKLAESAEGKNIFFSPWGISASLAMVYLGTKGTTAAQMAQVLQFSRDQDSKFCPDSEKKRKMEFNVGKPEEIYSDFQTLISEINSSSHACILKTANRIYGEKTFPFHKKYLEDVKTYFGAEPQSVNFIGASDQIRKEINSWVEKQTEGKILNLLPDDAVDPTTRMVLVNALYFKGVWEHQFLVQNTTEKSFKINKTTSKPVQMMSMKEKLQVFYIESPQAMGLQLYYESRDLSLLILLPEDVDGLDQVKGSVYSYLPPFLSPLLEKTITYEKLSEWTSADMMELCNVQLNLPKFKLEETYDLKSTLSSMGMSDAFNQSKADFSGMSSERNLFLSNVFHKCFVEINEQGTEAAAGTGSEVSVRMKLPSIEFNADHPFLFFIRHNKTNGILFYGRFCSP", "length": 413, "header": "tr|A0AAF6YHT9-1|A0AAF6YHT9_BOVIN Isoform 1 of Serpin B10 OS=Bos taurus OX=9913 GN=SERPINB10 PE=3 SV=1 CANONICAL=A0AAF6YHT9-1" }, "locus": { "chromosome": "24", "start_pos": 62122445, "end_pos": 62103474, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001458.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001458.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001458.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001458.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of blood coagulation", "id": "GO:0030195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030195", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "pmid": "" }, { "name": "negative regulation of proteolysis", "id": "GO:0045861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045861", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHT9" }, { "id": "SM00093", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serpin", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 413, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 201, "end_pos": 203 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 399, "end_pos": 401 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YI58-1", "uniprot_ac": "A0AAF6YI58", "uniprot_id": "A0AAF6YI58_BOVIN", "mass": { "chemical_mass": 23626.0, "monoisotopic_mass": 23626.0 }, "refseq": {}, "gene_names": [ { "name": "RSL24D1", "type": "recommended", "evidence": [ { "id": "A0AAF6YI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ] } ], "protein_names": [ { "name": "Probable ribosome biogenesis protein RLP24", "type": "recommended", "evidence": [ { "id": "A0AAF6YI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal L24 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58#function" }, { "database": "UniProtKB", "id": "ARBA00037035", "url": "https://www.uniprot.org/uniprotkb/ARBA00037035#function" }, { "database": "UniProtKB", "id": "A0ABI0NKG4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKG4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSL24D1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58", "locus": { "chromosome": "10", "start_pos": 55113416, "end_pos": 55099533, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001342", "url": "https://www.ensembl.org/id/ENSBTAG00000001342" } ] } } ], "crossref": [ { "id": "A0AAF6YI58", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YI58", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00472", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00472", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YI58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKG4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKG4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKG4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLFLENWEENHFLWRGYVTSSSAGRSAGESPRAFNMRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDVKEVKQNIHLIRAPLAGKGKQLEDKMVQKLQEDVDMEDVS", "length": 198, "header": "tr|A0AAF6YI58-1|A0AAF6YI58_BOVIN Isoform 1 of Probable ribosome biogenesis protein RLP24 OS=Bos taurus OX=9913 GN=RSL24D1 PE=3 SV=1 CANONICAL=A0AAF6YI58-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YI58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58/entry", "sequence": { "sequence": "MLFLENWEENHFLWRGYVTSSSAGRSAGESPRAFNMRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDVKEVKQNIHLIRAPLAGKGKQLEDKMVQKLQEDVDMEDVS", "length": 198, "header": "tr|A0AAF6YI58-1|A0AAF6YI58_BOVIN Isoform 1 of Probable ribosome biogenesis protein RLP24 OS=Bos taurus OX=9913 GN=RSL24D1 PE=3 SV=1 CANONICAL=A0AAF6YI58-1" }, "locus": { "chromosome": "10", "start_pos": 55112717, "end_pos": 55099732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001767.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001767.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001767.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001767.4" } ] } }, { "isoform_ac": "A0ABI0NKG4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKG4/entry", "sequence": { "sequence": "MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPVKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDVKEVKQNIHLIRAPLAGKKAAGRQNGTEITRGCGHGRCFLKLSVSISFKCIW", "length": 175, "header": "tr|A0ABI0NKG4-1|A0ABI0NKG4_BOVIN Computationally mapped isoform of Probable ribosome biogenesis protein RLP24 OS=Bos taurus OX=9913 GN=RSL24D1 PE=3 SV=1 CANONICAL=A0AAF6YI58-1" }, "locus": { "chromosome": "10", "start_pos": 55112757, "end_pos": 55099837, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145953.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145953.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104896.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104896.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YI58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI58" }, { "id": "SM00746", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00746" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TRASH", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 79, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YIB1-1", "uniprot_ac": "A0AAF6YIB1", "uniprot_id": "A0AAF6YIB1_BOVIN", "mass": { "chemical_mass": 97382.0, "monoisotopic_mass": 97382.0 }, "refseq": {}, "gene_names": [ { "name": "SRRT", "type": "recommended", "evidence": [ { "id": "A0AAF6YIB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ] } ], "protein_names": [ { "name": "Serrate RNA effector molecule homolog", "type": "recommended", "evidence": [ { "id": "A0AAF6YIB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1/entry#names_and_taxonomy" } ] }, { "name": "Arsenite-resistance protein 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YIB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1#function" }, { "database": "UniProtKB", "id": "ARBA00046030", "url": "https://www.uniprot.org/uniprotkb/ARBA00046030#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRRT", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1", "locus": { "chromosome": "25", "start_pos": 35770286, "end_pos": 35784480, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001134", "url": "https://www.ensembl.org/id/ENSBTAG00000001134" } ] } } ], "crossref": [ { "id": "A0AAF6YIB1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YIB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13165:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13165:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04959", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04959", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPAYGPPQPWGHPDVHIVQHPVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDAVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMESGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPNKKEESRVGPGLGDGERKANEKDDKKEDGKQAENESSSDDKIKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEADETLKEKEKPKEEEREKPKDAPGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLVHTLDDRTQLWAPEPGTPALPASLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQSLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNR", "length": 848, "header": "tr|A0AAF6YIB1-1|A0AAF6YIB1_BOVIN Isoform 1 of Serrate RNA effector molecule homolog OS=Bos taurus OX=9913 GN=SRRT PE=3 SV=1 CANONICAL=A0AAF6YIB1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YIB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1/entry", "sequence": { "sequence": "MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPAYGPPQPWGHPDVHIVQHPVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDAVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMESGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPNKKEESRVGPGLGDGERKANEKDDKKEDGKQAENESSSDDKIKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEADETLKEKEKPKEEEREKPKDAPGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLVHTLDDRTQLWAPEPGTPALPASLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQSLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNR", "length": 848, "header": "tr|A0AAF6YIB1-1|A0AAF6YIB1_BOVIN Isoform 1 of Serrate RNA effector molecule homolog OS=Bos taurus OX=9913 GN=SRRT PE=3 SV=1 CANONICAL=A0AAF6YIB1-1" }, "locus": { "chromosome": "25", "start_pos": 35783903, "end_pos": 35770631, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001507.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001507.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001507.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001507.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 544, "start_aa": "Thr", "end_pos": 544, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr544", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "mRNA cap binding complex binding", "id": "GO:0140262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140262", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "neuronal stem cell population maintenance", "id": "GO:0097150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097150", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "positive regulation of neurogenesis", "id": "GO:0050769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050769", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" }, { "name": "primary miRNA processing", "id": "GO:0031053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031053", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIB1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 560, "end_pos": 562, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YIB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" }, { "id": "PF04959", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04959" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SERRATE/Ars2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 646, "end_pos": 847, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YIB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIB1" }, { "id": "PF12066", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12066" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SERRATE/Ars2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 153, "end_pos": 262, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 544 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 560, "end_pos": 562 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YIC2-1", "uniprot_ac": "A0AAF6YIC2", "uniprot_id": "A0AAF6YIC2_BOVIN", "mass": { "chemical_mass": 38804.0, "monoisotopic_mass": 38804.0 }, "refseq": { "ac": "XP_059742154", "name": "heterogeneous nuclear ribonucleoprotein A1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742154" }, "gene_names": [ { "name": "HNRNPA1", "type": "recommended", "evidence": [ { "id": "A0AAF6YIC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ] }, { "name": "HNRNPA1", "type": "synonym", "evidence": [ { "id": "XP_059742154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742154" } ] }, { "name": "HNRPA1", "type": "synonym", "evidence": [ { "id": "XP_059742154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742154" } ] }, { "name": "hnRNP A1", "type": "synonym", "evidence": [ { "id": "XP_059742154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742154" } ] } ], "protein_names": [ { "name": "Heteroous nuclear ribonucleoprotein A1", "type": "synonym", "evidence": [ { "id": "A0AAF6YIC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2/entry#names_and_taxonomy" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein A1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059742154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742154" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HNRNPA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2", "locus": { "chromosome": "5", "start_pos": 25781133, "end_pos": 25785642, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001553", "url": "https://www.ensembl.org/id/ENSBTAG00000001553" } ] } } ], "crossref": [ { "id": "A0AAF6YIC2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YIC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001553", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001553", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12582", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12582", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505093", "url": "https://www.ncbi.nlm.nih.gov/gene/505093", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MTY3", "url": "https://www.orthodb.org/?gene=F1MTY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48026:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48026:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11627", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11627", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059742154", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742154", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTY3", "url": "https://www.uniprot.org/uniprotkb/F1MTY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MTY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF", "length": 373, "header": "tr|A0AAF6YIC2-1|A0AAF6YIC2_BOVIN Isoform 1 of Heteroous nuclear ribonucleoprotein A1 OS=Bos taurus OX=9913 GN=HNRNPA1 PE=4 SV=1 CANONICAL=A0AAF6YIC2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YIC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2/entry", "sequence": { "sequence": "MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF", "length": 373, "header": "tr|A0AAF6YIC2-1|A0AAF6YIC2_BOVIN Isoform 1 of Heteroous nuclear ribonucleoprotein A1 OS=Bos taurus OX=9913 GN=HNRNPA1 PE=4 SV=1 CANONICAL=A0AAF6YIC2-1" }, "locus": { "chromosome": "5", "start_pos": 25785580, "end_pos": 25782100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002033.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002033.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002033.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002033.6" } ] } }, { "isoform_ac": "F1MTY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MTY3/entry", "sequence": { "sequence": "MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF", "length": 267, "header": "tr|F1MTY3-1|A0AAF6YIC2_BOVIN Computationally mapped isoform of Heteroous nuclear ribonucleoprotein A1 OS=Bos taurus OX=9913 GN=HNRNPA1 PE=4 SV=3 CANONICAL=A0AAF6YIC2-1" }, "locus": { "chromosome": "5", "start_pos": 25785580, "end_pos": 25782100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013110.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013110.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013110.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013110.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "pre-mRNA binding", "id": "GO:0036002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036002", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "G-rich strand telomeric DNA binding", "id": "GO:0098505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098505", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "telomeric repeat-containing RNA binding", "id": "GO:0061752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061752", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "miRNA binding", "id": "GO:0035198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "import into nucleus", "id": "GO:0051170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051170", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "negative regulation of telomere maintenance via telomerase", "id": "GO:0032211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032211", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "positive regulation of telomere maintenance via telomerase", "id": "GO:0032212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032212", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "cellular response to glucose starvation", "id": "GO:0042149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "nuclear export", "id": "GO:0051168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051168", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "cellular response to sodium arsenite", "id": "GO:1903936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903936", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YIC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIC2" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 97, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 221, "end_pos": 223 }, { "start_pos": 321, "end_pos": 323 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YIK1-1", "uniprot_ac": "A0AAF6YIK1", "uniprot_id": "A0AAF6YIK1_BOVIN", "mass": { "chemical_mass": 50822.0, "monoisotopic_mass": 50822.0 }, "refseq": {}, "gene_names": [ { "name": "TRMT6", "type": "recommended", "evidence": [ { "id": "A0AAF6YIK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1" } ] } ], "protein_names": [ { "name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "type": "recommended", "evidence": [ { "id": "A0AAF6YIK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1#function" }, { "database": "UniProtKB", "id": "PIRNR038170", "url": "https://www.uniprot.org/uniprotkb/PIRNR038170#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRMT6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1", "locus": { "chromosome": "13", "start_pos": 48110221, "end_pos": 48120755, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001314", "url": "https://www.ensembl.org/id/ENSBTAG00000001314" } ] } } ], "crossref": [ { "id": "A0AAF6YIK1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YIK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR017423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12945:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12945:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSEDQPGPQPQYPGNHCIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNIIGHSYGTTFEVTNGGSLQPKKKKEEPTSETKEAGTDNRNIIDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAMITVVKPSTRILSVMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLNGTFSAEMLSSEPKDIASVEESNGTLEEKQTSEQENEDSIAEAPESNHPEEQERMEIVSQDPDYKEPKESGSKKDYIQEKQRRQEEQKKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKENSVYAFSLCWSATQNFGKEEGSSTSGCLKPGSEITRFCQIEVIPNY", "length": 451, "header": "tr|A0AAF6YIK1-1|A0AAF6YIK1_BOVIN Isoform 1 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Bos taurus OX=9913 GN=TRMT6 PE=3 SV=1 CANONICAL=A0AAF6YIK1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YIK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1/entry", "sequence": { "sequence": "MESSEDQPGPQPQYPGNHCIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNIIGHSYGTTFEVTNGGSLQPKKKKEEPTSETKEAGTDNRNIIDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAMITVVKPSTRILSVMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLNGTFSAEMLSSEPKDIASVEESNGTLEEKQTSEQENEDSIAEAPESNHPEEQERMEIVSQDPDYKEPKESGSKKDYIQEKQRRQEEQKKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKENSVYAFSLCWSATQNFGKEEGSSTSGCLKPGSEITRFCQIEVIPNY", "length": 451, "header": "tr|A0AAF6YIK1-1|A0AAF6YIK1_BOVIN Isoform 1 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Bos taurus OX=9913 GN=TRMT6 PE=3 SV=1 CANONICAL=A0AAF6YIK1-1" }, "locus": { "chromosome": "13", "start_pos": 48120514, "end_pos": 48110452, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001734.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001734.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001734.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001734.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1" } ], "pmid": "" }, { "name": "tRNA (m1A) methyltransferase complex", "id": "GO:0031515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031515", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1" } ], "pmid": "" }, { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YIK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 289, "end_pos": 291 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJ06-1", "uniprot_ac": "A0AAF6YJ06", "uniprot_id": "A0AAF6YJ06_BOVIN", "mass": { "chemical_mass": 23557.0, "monoisotopic_mass": 23557.0 }, "refseq": {}, "gene_names": [ { "name": "SPP2", "type": "recommended", "evidence": [ { "id": "A0AAF6YJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06" } ] } ], "protein_names": [ { "name": "Secreted phosphoprotein 24", "type": "recommended", "evidence": [ { "id": "A0AAF6YJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06/entry#names_and_taxonomy" } ] }, { "name": "Secreted phosphoprotein 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Could coordinate an aspect of bone turnover.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06#function" }, { "database": "UniProtKB", "id": "ARBA00002371", "url": "https://www.uniprot.org/uniprotkb/ARBA00002371#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06", "locus": { "chromosome": "3", "start_pos": 113730899, "end_pos": 113703201, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002030", "url": "https://www.ensembl.org/id/ENSBTAG00000002030" } ] } } ], "crossref": [ { "id": "A0AAF6YJ06", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJ06", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15444", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15444", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15444:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15444:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VLPIMEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSVKRVNALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAEQVQNVWVRCHWSSSSGSSSSEEMFFGDILGSSTSRNSYLLGLTPDRSRGEPLYEPSREMRRNFPLGNRRYSNPWPRARVNPGFE", "length": 207, "header": "tr|A0AAF6YJ06-1|A0AAF6YJ06_BOVIN Isoform 1 of Secreted phosphoprotein 24 OS=Bos taurus OX=9913 GN=SPP2 PE=3 SV=1 CANONICAL=A0AAF6YJ06-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJ06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06/entry", "sequence": { "sequence": "VLPIMEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSVKRVNALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAEQVQNVWVRCHWSSSSGSSSSEEMFFGDILGSSTSRNSYLLGLTPDRSRGEPLYEPSREMRRNFPLGNRRYSNPWPRARVNPGFE", "length": 207, "header": "tr|A0AAF6YJ06-1|A0AAF6YJ06_BOVIN Isoform 1 of Secreted phosphoprotein 24 OS=Bos taurus OX=9913 GN=SPP2 PE=3 SV=1 CANONICAL=A0AAF6YJ06-1" }, "locus": { "chromosome": "3", "start_pos": 113723323, "end_pos": 113703330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002631.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002631.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002631.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002631.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "bone remodeling", "id": "GO:0046849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046849", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJ26-1", "uniprot_ac": "A0AAF6YJ26", "uniprot_id": "A0AAF6YJ26_BOVIN", "mass": { "chemical_mass": 34100.0, "monoisotopic_mass": 34100.0 }, "refseq": { "ac": "XP_005213820", "name": "gamma-sarcoglycan isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213820" }, "gene_names": [ { "name": "SGCG", "type": "recommended", "evidence": [ { "id": "A0AAF6YJ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26" } ] }, { "name": "SGCG", "type": "synonym", "evidence": [ { "id": "XP_005213820", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213820" } ] } ], "protein_names": [ { "name": "Gamma-sarcoglycan", "type": "recommended", "evidence": [ { "id": "A0AAF6YJ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26/entry#names_and_taxonomy" } ] }, { "name": "gamma-sarcoglycan isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005213820", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213820" } ] } ], "function": [ { "annotation": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26#function" }, { "database": "UniProtKB", "id": "ARBA00002860", "url": "https://www.uniprot.org/uniprotkb/ARBA00002860#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SGCG", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26", "locus": { "chromosome": "12", "start_pos": 34674911, "end_pos": 34720620, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001865", "url": "https://www.ensembl.org/id/ENSBTAG00000001865" } ] } } ], "crossref": [ { "id": "A0AAF6YJ26", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJ26", "database": "AlphaFoldDB", "categories": [] }, { "id": "506155", "url": "https://www.ncbi.nlm.nih.gov/gene/506155", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12939", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12939", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12939:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12939:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04790", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04790", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213820", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213820", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDLAEPARTPRPGEAAQMVREQYTTITEGTHIERPENQAVYKIGIYGWRKRCLYLFVLLLLIVLLVNFALTIWILRVMWFSPVGMGHLHVTADGLHLEGESEFLFPLYVKEIRSRVDSSLLLQSTQNVTMNARNTEGEVTGRLKVGPQMVEVQSQQFQIHSKDGKPLFTVDEEKVMVGTDKLRVTGPEGALFEHSVETPLVRPDPPQDLRLESPTRSLSMDAPKGIHIQAPAGKIEALTQMDIVLQSSDGTVVLDAETVCLPELALGSQGPAGSSQGLYEVCVCPDGKLYLSVAGMGTTCHEHSHLCL", "length": 309, "header": "tr|A0AAF6YJ26-1|A0AAF6YJ26_BOVIN Isoform 1 of Gamma-sarcoglycan OS=Bos taurus OX=9913 GN=SGCG PE=3 SV=1 CANONICAL=A0AAF6YJ26-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJ26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26/entry", "sequence": { "sequence": "MEDLAEPARTPRPGEAAQMVREQYTTITEGTHIERPENQAVYKIGIYGWRKRCLYLFVLLLLIVLLVNFALTIWILRVMWFSPVGMGHLHVTADGLHLEGESEFLFPLYVKEIRSRVDSSLLLQSTQNVTMNARNTEGEVTGRLKVGPQMVEVQSQQFQIHSKDGKPLFTVDEEKVMVGTDKLRVTGPEGALFEHSVETPLVRPDPPQDLRLESPTRSLSMDAPKGIHIQAPAGKIEALTQMDIVLQSSDGTVVLDAETVCLPELALGSQGPAGSSQGLYEVCVCPDGKLYLSVAGMGTTCHEHSHLCL", "length": 309, "header": "tr|A0AAF6YJ26-1|A0AAF6YJ26_BOVIN Isoform 1 of Gamma-sarcoglycan OS=Bos taurus OX=9913 GN=SGCG PE=3 SV=1 CANONICAL=A0AAF6YJ26-1" }, "locus": { "chromosome": "12", "start_pos": 34720558, "end_pos": 34675524, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002431.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002431.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002431.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002431.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26" } ], "pmid": "" }, { "name": "sarcoglycan complex", "id": "GO:0016012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016012", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJ57-1", "uniprot_ac": "A0AAF6YJ57", "uniprot_id": "A0AAF6YJ57_BOVIN", "mass": { "chemical_mass": 24024.0, "monoisotopic_mass": 24024.0 }, "refseq": {}, "gene_names": [ { "name": "CDK2AP2", "type": "recommended", "evidence": [ { "id": "A0AAF6YJ57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57" } ] } ], "protein_names": [ { "name": "Cyclin dependent kinase 2 associated protein 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YJ57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ57", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDK2AP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57", "locus": { "chromosome": "29", "start_pos": 45388455, "end_pos": 45390555, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002121", "url": "https://www.ensembl.org/id/ENSBTAG00000002121" } ] } } ], "crossref": [ { "id": "A0AAF6YJ57", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJ57", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR017266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22607", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22607", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22607:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22607:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09806", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09806", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YJ57", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RIVRARPPFRPELYLPGACCRPANQSAAQRPGSQPGRSGRPASAAPRSWGCPTSPSPPPPAAPPAPARLGPAPRSRQVRTQLHPCLPARAVKVSEEKTARVLQCARPAACPRRASVCWPVKWAWSPGSVPSPSGSVPGAAGPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART", "length": 225, "header": "tr|A0AAF6YJ57-1|A0AAF6YJ57_BOVIN Isoform 1 of Cyclin dependent kinase 2 associated protein 2 OS=Bos taurus OX=9913 GN=CDK2AP2 PE=3 SV=1 CANONICAL=A0AAF6YJ57-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJ57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57/entry", "sequence": { "sequence": "RIVRARPPFRPELYLPGACCRPANQSAAQRPGSQPGRSGRPASAAPRSWGCPTSPSPPPPAAPPAPARLGPAPRSRQVRTQLHPCLPARAVKVSEEKTARVLQCARPAACPRRASVCWPVKWAWSPGSVPSPSGSVPGAAGPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART", "length": 225, "header": "tr|A0AAF6YJ57-1|A0AAF6YJ57_BOVIN Isoform 1 of Cyclin dependent kinase 2 associated protein 2 OS=Bos taurus OX=9913 GN=CDK2AP2 PE=3 SV=1 CANONICAL=A0AAF6YJ57-1" }, "locus": { "chromosome": "29", "start_pos": 45390356, "end_pos": 45388922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002738.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002738.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002738.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002738.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJ57", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJB3-1", "uniprot_ac": "A0AAF6YJB3", "uniprot_id": "A0AAF6YJB3_BOVIN", "mass": { "chemical_mass": 11055.0, "monoisotopic_mass": 11055.0 }, "refseq": {}, "gene_names": [ { "name": "TIMM8B", "type": "recommended", "evidence": [ { "id": "A0AAF6YJB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit", "type": "recommended", "evidence": [ { "id": "A0AAF6YJB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3#function" }, { "database": "UniProtKB", "id": "RU367043", "url": "https://www.uniprot.org/uniprotkb/RU367043#function" } ] }, { "annotation": "Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3#function" }, { "database": "UniProtKB", "id": "ARBA00058391", "url": "https://www.uniprot.org/uniprotkb/ARBA00058391#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM8B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3", "locus": { "chromosome": "15", "start_pos": 22395340, "end_pos": 22397344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002000", "url": "https://www.ensembl.org/id/ENSBTAG00000002000" } ] } } ], "crossref": [ { "id": "A0AAF6YJB3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF02953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRLRKVGNWTRKMAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQRGGQ", "length": 96, "header": "tr|A0AAF6YJB3-1|A0AAF6YJB3_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit OS=Bos taurus OX=9913 GN=TIMM8B PE=3 SV=1 CANONICAL=A0AAF6YJB3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3/entry", "sequence": { "sequence": "MRRLRKVGNWTRKMAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQRGGQ", "length": 96, "header": "tr|A0AAF6YJB3-1|A0AAF6YJB3_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit OS=Bos taurus OX=9913 GN=TIMM8B PE=3 SV=1 CANONICAL=A0AAF6YJB3-1" }, "locus": { "chromosome": "15", "start_pos": 22397344, "end_pos": 22395573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002594.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002594.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002594.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002594.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YJB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB3" }, { "id": "PF02953", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02953" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tim10-like", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 89, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJG5-1", "uniprot_ac": "A0AAF6YJG5", "uniprot_id": "A0AAF6YJG5_BOVIN", "mass": { "chemical_mass": 17822.0, "monoisotopic_mass": 17822.0 }, "refseq": {}, "gene_names": [ { "name": "NPFF", "type": "recommended", "evidence": [ { "id": "A0AAF6YJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5" } ] } ], "protein_names": [ { "name": "Neuropeptide FF-amide peptide", "type": "synonym", "evidence": [ { "id": "A0AAF6YJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPFF", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5", "locus": { "chromosome": "5", "start_pos": 26518582, "end_pos": 26513414, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002401", "url": "https://www.ensembl.org/id/ENSBTAG00000002401" } ] } } ], "crossref": [ { "id": "A0AAF6YJG5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15044", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15044", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15044:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15044:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAGQHSHPPEPFIRFCLGLPLRRLWEVRNRGTAGIRGGCGHSKADGSMDARQAAALLLVLLLVTDWSHAEGPGGRDGGDQIFMEEDSGAHPAQDAQTPRSLLRSLLQAMQRPGRSPAFLFQPQRFGRNTRGSWSNKRLSPRAGEGLSSPFWSLAAPQRFGKK", "length": 163, "header": "tr|A0AAF6YJG5-1|A0AAF6YJG5_BOVIN Isoform 1 of Neuropeptide FF-amide peptide OS=Bos taurus OX=9913 GN=NPFF PE=4 SV=1 CANONICAL=A0AAF6YJG5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5/entry", "sequence": { "sequence": "MVAGQHSHPPEPFIRFCLGLPLRRLWEVRNRGTAGIRGGCGHSKADGSMDARQAAALLLVLLLVTDWSHAEGPGGRDGGDQIFMEEDSGAHPAQDAQTPRSLLRSLLQAMQRPGRSPAFLFQPQRFGRNTRGSWSNKRLSPRAGEGLSSPFWSLAAPQRFGKK", "length": 163, "header": "tr|A0AAF6YJG5-1|A0AAF6YJG5_BOVIN Isoform 1 of Neuropeptide FF-amide peptide OS=Bos taurus OX=9913 GN=NPFF PE=4 SV=1 CANONICAL=A0AAF6YJG5-1" }, "locus": { "chromosome": "5", "start_pos": 26518496, "end_pos": 26513517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003109.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003109.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003109.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003109.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "neuropeptide hormone activity", "id": "GO:0005184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005184", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YJP2-1", "uniprot_ac": "A0AAF6YJP2", "uniprot_id": "A0AAF6YJP2_BOVIN", "mass": { "chemical_mass": 25691.0, "monoisotopic_mass": 25691.0 }, "refseq": {}, "gene_names": [ { "name": "SSU72", "type": "recommended", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ], "protein_names": [ { "name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "type": "recommended", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2/entry#names_and_taxonomy" } ] }, { "name": "CTD phosphatase SSU72", "type": "synonym", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2#function" }, { "database": "UniProtKB", "id": "RU369031", "url": "https://www.uniprot.org/uniprotkb/RU369031#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSU72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2", "locus": {} } ], "crossref": [ { "id": "A0AAF6YJP2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YJP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04722", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04722", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YJP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSGRGGRHLARAEAARLGGSPEVGVADGAAAAMPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY", "length": 227, "header": "tr|A0AAF6YJP2-1|A0AAF6YJP2_BOVIN Isoform 1 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Bos taurus OX=9913 GN=SSU72 PE=3 SV=1 CANONICAL=A0AAF6YJP2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2/entry", "sequence": { "sequence": "MTSGRGGRHLARAEAARLGGSPEVGVADGAAAAMPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVINVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY", "length": 227, "header": "tr|A0AAF6YJP2-1|A0AAF6YJP2_BOVIN Isoform 1 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Bos taurus OX=9913 GN=SSU72 PE=3 SV=1 CANONICAL=A0AAF6YJP2-1" }, "locus": { "chromosome": "16", "start_pos": 51077795, "end_pos": 51053535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003331.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003331.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003331.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003331.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA 3'-end processing", "id": "GO:0031124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031124", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase II CTD heptapeptide repeat phosphatase activity", "id": "GO:0008420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008420", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YJP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] } ] }, { "uniprot_ac": "A0A3Q1MV48", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] } ] }, { "uniprot_ac": "A0A3Q1N5B2", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S454", "gene_name": "LOC112441581", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] } ] }, { "uniprot_ac": "A0AAA9S745", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2KJD7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] }, { "uniprot_ac": "Q3SWW9", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.53", "activity": "O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] } ] }, { "uniprot_ac": "Q3T0E7", "gene_name": "PPP1CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] } ] }, { "uniprot_ac": "Q3ZBF9", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] } ] }, { "uniprot_ac": "Q58DC0", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.16", "ec_name": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16" }, { "id": "3.1.3.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.16" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YK00-1", "uniprot_ac": "A0AAF6YK00", "uniprot_id": "A0AAF6YK00_BOVIN", "mass": { "chemical_mass": 65166.0, "monoisotopic_mass": 65166.0 }, "refseq": {}, "gene_names": [ { "name": "CIAO3", "type": "recommended", "evidence": [ { "id": "A0AAF6YK00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ] } ], "protein_names": [ { "name": "Cytosolic iron-sulfur assembly component 3", "type": "synonym", "evidence": [ { "id": "A0AAF6YK00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIAO3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00", "locus": { "chromosome": "25", "start_pos": 628544, "end_pos": 635347, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002484", "url": "https://www.ensembl.org/id/ENSBTAG00000002484" } ] } } ], "crossref": [ { "id": "A0AAF6YK00", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YK00", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11615", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11615", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YK00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTRRFPAVWRNCLAVSRRLATPSGPGPAVVWRHGVALQRGPAADGLGRLHRAVSGGRAGRLLRARSPLRRGLPRQPEREARDRGACWVAQPRGFRVPFPGGHDNQLGAGRPRRTSLAGSSPHREGKGGRSAAVSAVVGDCIKPMKVDRRPGSGVAKIHIEDDGSYFQVSQDGGMKKLEKAKISLDDCLACSGCVTSAETVLITQQSHEELRKVLGANKTAAPDQQKLVVISVSPQSRASLAVRFQLNPTDTARKLTAFFKKIGAHYVFDTAFSRNFSLLESQREFVRRFRGQADPEQALPVLTSACPGWICYAEKTHGSTLLPHISTARSPQQVMGSLVKDFFAQQQHLTPDKVYHATVMPCYDKKLEASRPDFFSQEHQTRDVDCVITTGEVFKLLEEEGVSLSELEPAPLDSLCSSASAQEPTSHQGGGSGGYLEHVFRHAAQELFGIHVTEVTYRPLRNKDLQEVILEREGQVLLHFAAAYGFRNIQNLVQKLKRGRCPYHYVEVMACPAGCLNGGGQLKAPDMPGKELLQQVERLYGLVRTEAPEDAPGIQELYERWLQGAGSERAGRLLHTSYHAVEKAGSGLSIRW", "length": 593, "header": "tr|A0AAF6YK00-1|A0AAF6YK00_BOVIN Isoform 1 of Cytosolic iron-sulfur assembly component 3 OS=Bos taurus OX=9913 GN=CIAO3 PE=3 SV=1 CANONICAL=A0AAF6YK00-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YK00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00/entry", "sequence": { "sequence": "MRTRRFPAVWRNCLAVSRRLATPSGPGPAVVWRHGVALQRGPAADGLGRLHRAVSGGRAGRLLRARSPLRRGLPRQPEREARDRGACWVAQPRGFRVPFPGGHDNQLGAGRPRRTSLAGSSPHREGKGGRSAAVSAVVGDCIKPMKVDRRPGSGVAKIHIEDDGSYFQVSQDGGMKKLEKAKISLDDCLACSGCVTSAETVLITQQSHEELRKVLGANKTAAPDQQKLVVISVSPQSRASLAVRFQLNPTDTARKLTAFFKKIGAHYVFDTAFSRNFSLLESQREFVRRFRGQADPEQALPVLTSACPGWICYAEKTHGSTLLPHISTARSPQQVMGSLVKDFFAQQQHLTPDKVYHATVMPCYDKKLEASRPDFFSQEHQTRDVDCVITTGEVFKLLEEEGVSLSELEPAPLDSLCSSASAQEPTSHQGGGSGGYLEHVFRHAAQELFGIHVTEVTYRPLRNKDLQEVILEREGQVLLHFAAAYGFRNIQNLVQKLKRGRCPYHYVEVMACPAGCLNGGGQLKAPDMPGKELLQQVERLYGLVRTEAPEDAPGIQELYERWLQGAGSERAGRLLHTSYHAVEKAGSGLSIRW", "length": 593, "header": "tr|A0AAF6YK00-1|A0AAF6YK00_BOVIN Isoform 1 of Cytosolic iron-sulfur assembly component 3 OS=Bos taurus OX=9913 GN=CIAO3 PE=3 SV=1 CANONICAL=A0AAF6YK00-1" }, "locus": { "chromosome": "25", "start_pos": 635148, "end_pos": 629096, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003225.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003225.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003225.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003225.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "iron-sulfur cluster assembly", "id": "GO:0016226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016226", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ], "pmid": "" }, { "name": "intracellular oxygen homeostasis", "id": "GO:0032364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic [4Fe-4S] assembly targeting complex", "id": "GO:0097361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097361", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK00", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YK00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK00" }, { "id": "SM00902", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00902" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Iron hydrogenase small subunit", "eco_id": "ECO_0000259", "start_pos": 527, "end_pos": 583, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 218, "end_pos": 220 }, { "start_pos": 276, "end_pos": 278 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YK48-1", "uniprot_ac": "A0AAF6YK48", "uniprot_id": "A0AAF6YK48_BOVIN", "mass": { "chemical_mass": 33604.0, "monoisotopic_mass": 33604.0 }, "refseq": { "ac": "XP_024842347", "name": "collectin-43 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842347" }, "gene_names": [ { "name": "CL43", "type": "recommended", "evidence": [ { "id": "A0AAF6YK48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48" } ] }, { "name": "CL-43", "type": "synonym", "evidence": [ { "id": "XP_024842347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842347" } ] }, { "name": "CL43", "type": "synonym", "evidence": [ { "id": "XP_024842347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842347" } ] } ], "protein_names": [ { "name": "Collectin-43", "type": "synonym", "evidence": [ { "id": "A0AAF6YK48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48/entry#names_and_taxonomy" } ] }, { "name": "collectin-43 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024842347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842347" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CL43", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48", "locus": {} } ], "crossref": [ { "id": "A0AAF6YK48", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YK48", "database": "AlphaFoldDB", "categories": [] }, { "id": "431784", "url": "https://www.ncbi.nlm.nih.gov/gene/431784", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24024:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24024:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09006", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09006", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842347", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YK48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJA7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJA7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5T9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5T9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPLPLSILLLLTQSQSFLGEEMDVYSEKTLTDPCTVVVCAPPADSLRGHDGRDGKEGPQGEKGDPGPPGMPGPAGREGPSGRQGSMGPPGTPGPKGEPGPEGGVGAPGMPGSPGPTGLKGERGTPGPGGAIGPQGPSGAMGPPGLKGDRGDPGEKGAKGETSVLEVDTLRQRMRNLEGEVQRLQNIVTQYRKAVLFPDGQAVGEKIFKTAGAVKSYSDAEQLCREAKGQLASPRSSAENEAVTQLVRAKNKHAYLSMNDISKEGKFTYPTGGSLDYSNWAPGEPNNRAKDEGPENCLEIYSDGNWNDIECREERLVICEF", "length": 321, "header": "tr|A0AAF6YK48-1|A0AAF6YK48_BOVIN Isoform 1 of Collectin-43 OS=Bos taurus OX=9913 GN=CL43 PE=3 SV=1 CANONICAL=A0AAF6YK48-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YK48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48/entry", "sequence": { "sequence": "MLPLPLSILLLLTQSQSFLGEEMDVYSEKTLTDPCTVVVCAPPADSLRGHDGRDGKEGPQGEKGDPGPPGMPGPAGREGPSGRQGSMGPPGTPGPKGEPGPEGGVGAPGMPGSPGPTGLKGERGTPGPGGAIGPQGPSGAMGPPGLKGDRGDPGEKGAKGETSVLEVDTLRQRMRNLEGEVQRLQNIVTQYRKAVLFPDGQAVGEKIFKTAGAVKSYSDAEQLCREAKGQLASPRSSAENEAVTQLVRAKNKHAYLSMNDISKEGKFTYPTGGSLDYSNWAPGEPNNRAKDEGPENCLEIYSDGNWNDIECREERLVICEF", "length": 321, "header": "tr|A0AAF6YK48-1|A0AAF6YK48_BOVIN Isoform 1 of Collectin-43 OS=Bos taurus OX=9913 GN=CL43 PE=3 SV=1 CANONICAL=A0AAF6YK48-1" }, "locus": { "chromosome": "28", "start_pos": 35519070, "end_pos": 35512122, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003773.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003773.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003773.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003773.7" } ] } }, { "isoform_ac": "A0ABI0NJA7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA7/entry", "sequence": { "sequence": "MMDEMGKKAPRERRGIQGLQVCLDQLEERAPQGGRGAWDLQAHQAPKENLGPKEEWVPQACPAPQAPQVSKEREVPLVSPESLEVLGRQLSNGHGDGLMFPCAYHHHPPGPGGAIGPQGPSGAMGPPGLKGDRGDPGEKGAKGETSVLEVDTLRQRMRNLEGEVQRLQNIVTQYRKAVLFPDGQAVGEKIFKTAGAVKSYSDAEQLCREAKGQLASPRSSAENEAVTQLVRAKNKHAYLSMNDISKEGKFTYPTGGSLDYSNWAPGEPNNRAKDEGPENCLEIYSDGNWNDIECREERLVICEF", "length": 304, "header": "tr|A0ABI0NJA7-1|A0ABI0NJA7_BOVIN Computationally mapped isoform of Collectin-43 OS=Bos taurus OX=9913 GN=CL43 PE=3 SV=1 CANONICAL=A0AAF6YK48-1" }, "locus": { "chromosome": "28", "start_pos": 35519070, "end_pos": 35512270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104487.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104487.1" } ] } }, { "isoform_ac": "A0ABI0P5T9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5T9/entry", "sequence": { "sequence": "MLPLPLSILLLLTQSQSFLGEEMDVYSEKTLTDPCTVVVCAPPADSLRGHDGRDGKEGPQGEKGDPGPPGMPGPAGREGPSGRQGSMGPPGTPGPKGEPGPEGGVGAPGMPGSPGPTGLKGERGTPGPGGAIGPQGPSGAMGPPGLKGDRGDPGEKGAKGETSVLEVDTLRQRMRNLEGEVQRLQNIVTQYRKEAQADTRDKEEDMVHVTSQQTFTTAHPGQVPRTYKGTPNPGCISSLCGARYANAQRRSCTVHSSRESSMILRVGVGCCPWGSRLLGTYPWCVAPKYLTLKMPLGLEGIGCLQSLASAGLSCTSCGV", "length": 319, "header": "tr|A0ABI0P5T9-1|A0ABI0P5T9_BOVIN Computationally mapped isoform of Collectin-43 OS=Bos taurus OX=9913 GN=CL43 PE=4 SV=1 CANONICAL=A0AAF6YK48-1" }, "locus": { "chromosome": "28", "start_pos": 35516856, "end_pos": 35512122, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146064.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146064.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106568.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 92, "start_aa": "Thr", "end_pos": 92, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr92", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YK48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK48" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 215, "end_pos": 320, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 92 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YK53-1", "uniprot_ac": "A0AAF6YK53", "uniprot_id": "A0AAF6YK53_BOVIN", "mass": { "chemical_mass": 36944.0, "monoisotopic_mass": 36944.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM115", "type": "recommended", "evidence": [ { "id": "A0AAF6YK53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ] } ], "protein_names": [ { "name": "Transmembrane protein 115", "type": "synonym", "evidence": [ { "id": "A0AAF6YK53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM115", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53", "locus": { "chromosome": "22", "start_pos": 49994447, "end_pos": 49989078, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058435", "url": "https://www.ensembl.org/id/ENSBTAG00000058435" } ] } } ], "crossref": [ { "id": "A0AAF6YK53", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YK53", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13377:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13377:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08551", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08551", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YK53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRALPGARQHLGAILSSASVVVKALCAAVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLGLLLLLRLATLLQSPALASYGFGLISSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSVWPSMDDDEEEAGAKDSCYLVPAPDNHSARHGTSEA", "length": 338, "header": "tr|A0AAF6YK53-1|A0AAF6YK53_BOVIN Isoform 1 of Transmembrane protein 115 OS=Bos taurus OX=9913 GN=TMEM115 PE=4 SV=1 CANONICAL=A0AAF6YK53-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YK53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53/entry", "sequence": { "sequence": "MQRALPGARQHLGAILSSASVVVKALCAAVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLGLLLLLRLATLLQSPALASYGFGLISSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSVWPSMDDDEEEAGAKDSCYLVPAPDNHSARHGTSEA", "length": 338, "header": "tr|A0AAF6YK53-1|A0AAF6YK53_BOVIN Isoform 1 of Transmembrane protein 115 OS=Bos taurus OX=9913 GN=TMEM115 PE=4 SV=1 CANONICAL=A0AAF6YK53-1" }, "locus": { "chromosome": "22", "start_pos": 49993443, "end_pos": 49989499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003411.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003411.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003411.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003411.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 48, "start_aa": "Thr", "end_pos": 48, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr48", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ], "pmid": "" }, { "name": "Golgi transport complex", "id": "GO:0017119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017119", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YK53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YK53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 48 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 328, "end_pos": 330 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YKG4-1", "uniprot_ac": "A0AAF6YKG4", "uniprot_id": "A0AAF6YKG4_BOVIN", "mass": { "chemical_mass": 24896.0, "monoisotopic_mass": 24896.0 }, "refseq": { "ac": "XP_015327198", "name": "gamma-crystallin S isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327198" }, "gene_names": [ { "name": "CRYGS", "type": "recommended", "evidence": [ { "id": "A0AAF6YKG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4" } ] }, { "name": "CRYGS", "type": "synonym", "evidence": [ { "id": "XP_015327198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327198" } ] } ], "protein_names": [ { "name": "Gamma-crystallin S", "type": "recommended", "evidence": [ { "id": "A0AAF6YKG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4/entry#names_and_taxonomy" } ] }, { "name": "Beta-crystallin S", "type": "synonym", "evidence": [ { "id": "A0AAF6YKG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4/entry#names_and_taxonomy" } ] }, { "name": "Gamma-S-crystallin", "type": "synonym", "evidence": [ { "id": "A0AAF6YKG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4/entry#names_and_taxonomy" } ] }, { "name": "gamma-crystallin S isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015327198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327198" } ] } ], "function": [ { "annotation": "Crystallins are the dominant structural components of the vertebrate eye lens.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4#function" }, { "database": "UniProtKB", "id": "ARBA00003689", "url": "https://www.uniprot.org/uniprotkb/ARBA00003689#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRYGS", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4", "locus": { "chromosome": "1", "start_pos": 80696502, "end_pos": 80695044, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003140", "url": "https://www.ensembl.org/id/ENSBTAG00000003140" } ] } } ], "crossref": [ { "id": "A0AAF6YKG4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YKG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "281724", "url": "https://www.ncbi.nlm.nih.gov/gene/281724", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11818:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11818:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015327198", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327198", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YKG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLSLKIMAYSRALLFGFILSPHKVLIPIADNQSCLPEGRCEITFFEDKNFQGRHYDSDCDCADFHMYLSRCNSIRVEGGTWAVYERPNFAGYMYILPRGEYPEYQHWMGLNDRLSSCRAVHLSSGGQYKLQIFEKGDFNGQMHETTEDCPSIMEQFHMREVHSCKVLEGAWIFYELPNYRGRQYLLDKKEYRKPVDWGAASPAVQSFRRIVE", "length": 213, "header": "tr|A0AAF6YKG4-1|A0AAF6YKG4_BOVIN Isoform 1 of Gamma-crystallin S OS=Bos taurus OX=9913 GN=CRYGS PE=3 SV=1 CANONICAL=A0AAF6YKG4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YKG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4/entry", "sequence": { "sequence": "MNLSLKIMAYSRALLFGFILSPHKVLIPIADNQSCLPEGRCEITFFEDKNFQGRHYDSDCDCADFHMYLSRCNSIRVEGGTWAVYERPNFAGYMYILPRGEYPEYQHWMGLNDRLSSCRAVHLSSGGQYKLQIFEKGDFNGQMHETTEDCPSIMEQFHMREVHSCKVLEGAWIFYELPNYRGRQYLLDKKEYRKPVDWGAASPAVQSFRRIVE", "length": 213, "header": "tr|A0AAF6YKG4-1|A0AAF6YKG4_BOVIN Isoform 1 of Gamma-crystallin S OS=Bos taurus OX=9913 GN=CRYGS PE=3 SV=1 CANONICAL=A0AAF6YKG4-1" }, "locus": { "chromosome": "1", "start_pos": 80696426, "end_pos": 80695243, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004084.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004084.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004084.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004084.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of eye lens", "id": "GO:0005212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005212", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YKG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKG4" }, { "id": "PS50915", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta/gamma crystallin 'Greek key'", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 122, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 }, { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YKL2-1", "uniprot_ac": "A0AAF6YKL2", "uniprot_id": "A0AAF6YKL2_BOVIN", "mass": { "chemical_mass": 45230.0, "monoisotopic_mass": 45230.0 }, "refseq": {}, "gene_names": [ { "name": "IMP4", "type": "recommended", "evidence": [ { "id": "A0AAF6YKL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ] } ], "protein_names": [ { "name": "IMP U3 small nucleolar ribonucleoprotein 4", "type": "synonym", "evidence": [ { "id": "A0AAF6YKL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2#function" }, { "database": "UniProtKB", "id": "ARBA00045281", "url": "https://www.uniprot.org/uniprotkb/ARBA00045281#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IMP4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2", "locus": { "chromosome": "2", "start_pos": 1323393, "end_pos": 1080651, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003225", "url": "https://www.ensembl.org/id/ENSBTAG00000003225" } ] } } ], "crossref": [ { "id": "A0AAF6YKL2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YKL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22734", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22734", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22734:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22734:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04427", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04427", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVGSPSPHRNWVQNPPPNPGKEAHQRETYQAFDHLQQLFHDHCNALVAKQPANDLEVIRRAPATRTVGKSWRKRGPRRRGLRCASGIQRFSWTHVEVALRMLRREARLRREYLYRKAREEAERTAQERKDKVRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTNHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTASEAKPHLIMHGFSSRLGKRVSDILRYLFPVPKDDSRRVITFANQDDYISFRHHVYKKTNHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTAHKRVFLSAE", "length": 392, "header": "tr|A0AAF6YKL2-1|A0AAF6YKL2_BOVIN Isoform 1 of IMP U3 small nucleolar ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=IMP4 PE=4 SV=1 CANONICAL=A0AAF6YKL2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YKL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2/entry", "sequence": { "sequence": "MGVGSPSPHRNWVQNPPPNPGKEAHQRETYQAFDHLQQLFHDHCNALVAKQPANDLEVIRRAPATRTVGKSWRKRGPRRRGLRCASGIQRFSWTHVEVALRMLRREARLRREYLYRKAREEAERTAQERKDKVRRALEENRLIPTELRREALALQGSLEFDDAGGEGVTNHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTASEAKPHLIMHGFSSRLGKRVSDILRYLFPVPKDDSRRVITFANQDDYISFRHHVYKKTNHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTAHKRVFLSAE", "length": 392, "header": "tr|A0AAF6YKL2-1|A0AAF6YKL2_BOVIN Isoform 1 of IMP U3 small nucleolar ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=IMP4 PE=4 SV=1 CANONICAL=A0AAF6YKL2-1" }, "locus": { "chromosome": "2", "start_pos": 1322978, "end_pos": 1080850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004184.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004184.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004184.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004184.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "pmid": "" }, { "name": "Mpp10 complex", "id": "GO:0034457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034457", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "rRNA primary transcript binding", "id": "GO:0042134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042134", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YKL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL2" }, { "id": "PS50833", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50833" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Brix", "eco_id": "ECO_0000259", "start_pos": 184, "end_pos": 365, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YKL8-1", "uniprot_ac": "A0AAF6YKL8", "uniprot_id": "A0AAF6YKL8_BOVIN", "mass": { "chemical_mass": 20647.0, "monoisotopic_mass": 20647.0 }, "refseq": {}, "gene_names": [ { "name": "LOC614882", "type": "recommended", "evidence": [ { "id": "A0AAF6YKL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ] } ], "protein_names": [ { "name": "Vacuolar ATPase assembly protein VMA22", "type": "recommended", "evidence": [ { "id": "A0AAF6YKL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 115", "type": "synonym", "evidence": [ { "id": "A0AAF6YKL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8#function" }, { "database": "UniProtKB", "id": "ARBA00059225", "url": "https://www.uniprot.org/uniprotkb/ARBA00059225#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC614882", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8", "locus": {} } ], "crossref": [ { "id": "A0AAF6YKL8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YKL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31996", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31996", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31996:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31996:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21730", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21730", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YKL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRDLRAEVDFVLLQLLGDLEQLEAKRQALNARVEEGWLSLSKARYAMGAKSVGPLQYASHMEPQVRVGTSESQDGLQKFWMVRAGTQTPEEVGSREAAFLSSALRRRKGLPRTPEPDSSPAPQNPLKWFGILVPHSLRQAQASFREGLQLAADMASLQSRITWGQSQLQELQEKLKQLEPRAP", "length": 185, "header": "tr|A0AAF6YKL8-1|A0AAF6YKL8_BOVIN Isoform 1 of Vacuolar ATPase assembly protein VMA22 OS=Bos taurus OX=9913 GN=LOC614882 PE=4 SV=1 CANONICAL=A0AAF6YKL8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YKL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8/entry", "sequence": { "sequence": "MASRDLRAEVDFVLLQLLGDLEQLEAKRQALNARVEEGWLSLSKARYAMGAKSVGPLQYASHMEPQVRVGTSESQDGLQKFWMVRAGTQTPEEVGSREAAFLSSALRRRKGLPRTPEPDSSPAPQNPLKWFGILVPHSLRQAQASFREGLQLAADMASLQSRITWGQSQLQELQEKLKQLEPRAP", "length": 185, "header": "tr|A0AAF6YKL8-1|A0AAF6YKL8_BOVIN Isoform 1 of Vacuolar ATPase assembly protein VMA22 OS=Bos taurus OX=9913 GN=LOC614882 PE=4 SV=1 CANONICAL=A0AAF6YKL8-1" }, "locus": { "chromosome": "2", "start_pos": 1318233, "end_pos": 1315405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004187.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004187.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004187.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004187.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ], "pmid": "" }, { "name": "COPI-coated vesicle", "id": "GO:0030137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030137", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "vacuolar proton-transporting V-type ATPase complex assembly", "id": "GO:0070072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070072", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YKL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YKL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YL38-1", "uniprot_ac": "A0AAF6YL38", "uniprot_id": "A0AAF6YL38_BOVIN", "mass": { "chemical_mass": 52292.0, "monoisotopic_mass": 52292.0 }, "refseq": {}, "gene_names": [ { "name": "RIBC2", "type": "recommended", "evidence": [ { "id": "A0AAF6YL38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38" } ] } ], "protein_names": [ { "name": "RIB43A domain with coiled-coils 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YL38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIBC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38", "locus": { "chromosome": "5", "start_pos": 115829117, "end_pos": 115818287, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003594", "url": "https://www.ensembl.org/id/ENSBTAG00000003594" } ] } } ], "crossref": [ { "id": "A0AAF6YL38", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YL38", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14517:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14517:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05914", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05914", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YL38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVAQPKDLKEDFVLAKRRHAELVRQKRIFNARNRIIGGDTTAWDAQVCDQNIKAATEKARDEAFAAEMRQNDKIACLSENRERRDRKNLCKAINDFQQSFQRPETRREFDLSDPLALKKDRPARQSDYDARNTISGMQKFMGEDLNFHLRKKFQEEQNREWSLQQQKEQMIGRENQKCAEDLYLKTRLQFDETAKHLQNLETATRKAVCATVKEFNKNQALESAEKKIQERKQEQEDNLAEISNMLRGDLLSENPQQAASSFGPHRVVPDRWKGMSQEQLEEIRLVQRQQVQEKLVPVPAPLPKPSAPHRSLHHHPSPPAPALRHGSVLPPAFLEHLVTAAVTLGPRSCPQGVYVPFVGEDKSGVIPQRLQEEERQRDMDWDRRRIQKARATLLFEQQQQRLQRGLRRALDCSNLSLAREQLLQKKHMKELCTNHATEDYFTQFNTGSR", "length": 450, "header": "tr|A0AAF6YL38-1|A0AAF6YL38_BOVIN Isoform 1 of RIB43A domain with coiled-coils 2 OS=Bos taurus OX=9913 GN=RIBC2 PE=3 SV=1 CANONICAL=A0AAF6YL38-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YL38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38/entry", "sequence": { "sequence": "MEVAQPKDLKEDFVLAKRRHAELVRQKRIFNARNRIIGGDTTAWDAQVCDQNIKAATEKARDEAFAAEMRQNDKIACLSENRERRDRKNLCKAINDFQQSFQRPETRREFDLSDPLALKKDRPARQSDYDARNTISGMQKFMGEDLNFHLRKKFQEEQNREWSLQQQKEQMIGRENQKCAEDLYLKTRLQFDETAKHLQNLETATRKAVCATVKEFNKNQALESAEKKIQERKQEQEDNLAEISNMLRGDLLSENPQQAASSFGPHRVVPDRWKGMSQEQLEEIRLVQRQQVQEKLVPVPAPLPKPSAPHRSLHHHPSPPAPALRHGSVLPPAFLEHLVTAAVTLGPRSCPQGVYVPFVGEDKSGVIPQRLQEEERQRDMDWDRRRIQKARATLLFEQQQQRLQRGLRRALDCSNLSLAREQLLQKKHMKELCTNHATEDYFTQFNTGSR", "length": 450, "header": "tr|A0AAF6YL38-1|A0AAF6YL38_BOVIN Isoform 1 of RIB43A domain with coiled-coils 2 OS=Bos taurus OX=9913 GN=RIBC2 PE=3 SV=1 CANONICAL=A0AAF6YL38-1" }, "locus": { "chromosome": "5", "start_pos": 115829010, "end_pos": 115818470, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004671.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004671.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004671.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004671.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38" } ], "pmid": "" }, { "name": "axonemal A tubule inner sheath", "id": "GO:0160111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160111", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 415, "end_pos": 417 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YL60-1", "uniprot_ac": "A0AAF6YL60", "uniprot_id": "A0AAF6YL60_BOVIN", "mass": { "chemical_mass": 27656.0, "monoisotopic_mass": 27656.0 }, "refseq": {}, "gene_names": [ { "name": "PRSS58", "type": "recommended", "evidence": [ { "id": "A0AAF6YL60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" } ] } ], "protein_names": [ { "name": "Protease, serine, 58", "type": "synonym", "evidence": [ { "id": "A0AAF6YL60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRSS58", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60", "locus": { "chromosome": "4", "start_pos": 105496428, "end_pos": 105502564, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003628", "url": "https://www.ensembl.org/id/ENSBTAG00000003628" } ] } } ], "crossref": [ { "id": "A0AAF6YL60", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YL60", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YL60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIMNLILLWALLNLPVALTFDPNYKDDITPPYLIYLKSDYLPCVGVLIHPLWVITAANCNLPRLQLILGVTKPSNIDEEKYVQVVGYEKMIHHPQFSITSIEHNLMLIKLQTHIELNNYVKIVSLPKEPAAEDDTCIVSTWAYNLCDHYKDPDSLQNVNISVISKVECLKAYKYMHIRDSMMCVGIVPGRRQPCKEVTAAPAVCNGILQGILTFADGCVLRADVGIYTRIINYIPWIENTIQNN", "length": 244, "header": "tr|A0AAF6YL60-1|A0AAF6YL60_BOVIN Isoform 1 of Protease, serine, 58 OS=Bos taurus OX=9913 GN=PRSS58 PE=4 SV=1 CANONICAL=A0AAF6YL60-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YL60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60/entry", "sequence": { "sequence": "MIMNLILLWALLNLPVALTFDPNYKDDITPPYLIYLKSDYLPCVGVLIHPLWVITAANCNLPRLQLILGVTKPSNIDEEKYVQVVGYEKMIHHPQFSITSIEHNLMLIKLQTHIELNNYVKIVSLPKEPAAEDDTCIVSTWAYNLCDHYKDPDSLQNVNISVISKVECLKAYKYMHIRDSMMCVGIVPGRRQPCKEVTAAPAVCNGILQGILTFADGCVLRADVGIYTRIINYIPWIENTIQNN", "length": 244, "header": "tr|A0AAF6YL60-1|A0AAF6YL60_BOVIN Isoform 1 of Protease, serine, 58 OS=Bos taurus OX=9913 GN=PRSS58 PE=4 SV=1 CANONICAL=A0AAF6YL60-1" }, "locus": { "chromosome": "4", "start_pos": 105502247, "end_pos": 105496494, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004732.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004732.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004732.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004732.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" } ], "pmid": "" }, { "name": "positive regulation of reproductive process", "id": "GO:2000243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000243", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL60", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YL60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL60" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 242, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YL90-1", "uniprot_ac": "A0AAF6YL90", "uniprot_id": "A0AAF6YL90_BOVIN", "mass": { "chemical_mass": 73919.0, "monoisotopic_mass": 73919.0 }, "refseq": {}, "gene_names": [ { "name": "ANGEL2", "type": "recommended", "evidence": [ { "id": "A0AAF6YL90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ] } ], "protein_names": [ { "name": "Angel homolog 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YL90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANGEL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90", "locus": { "chromosome": "16", "start_pos": 70598523, "end_pos": 70580252, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003702", "url": "https://www.ensembl.org/id/ENSBTAG00000003702" } ] } } ], "crossref": [ { "id": "A0AAF6YL90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YL90", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12121:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12121:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTWRRARSNFPACFAVGPRGPASSDGEPPVLDAAKSAVEVDVVTGAGNWKAAECKDGSVALCEEGLRPLCGGERPVSRAGWREGRGRGGRPGGGSERPRGTGAGGAGWGVGVGRGRGSGPRCRRDRPLETLRDRYPMLPHHQKSLGRDWTTPWENLQKCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPGLFESRAPFQYWNWRPDSLSQTSLFHLSSYIMNSEGDEPSSKRRKHQGTIQRHWEYICNHNKENTKILGDENVDPICEDSENKFEFSVMSYNILSQDLLEDNSHLYKHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFYRRDVPLLDRDNVGLVLLLQPKIPSATSPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGRFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKPDGDLTQPELDKTEVLVTAEKLSSNLQHHFSLSSVYSHYLPDTGIPEVTTCHSRSAVTVDYIFYSAEKEGVAEQPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL", "length": 659, "header": "tr|A0AAF6YL90-1|A0AAF6YL90_BOVIN Isoform 1 of Angel homolog 2 OS=Bos taurus OX=9913 GN=ANGEL2 PE=4 SV=1 CANONICAL=A0AAF6YL90-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YL90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90/entry", "sequence": { "sequence": "MGTWRRARSNFPACFAVGPRGPASSDGEPPVLDAAKSAVEVDVVTGAGNWKAAECKDGSVALCEEGLRPLCGGERPVSRAGWREGRGRGGRPGGGSERPRGTGAGGAGWGVGVGRGRGSGPRCRRDRPLETLRDRYPMLPHHQKSLGRDWTTPWENLQKCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPGLFESRAPFQYWNWRPDSLSQTSLFHLSSYIMNSEGDEPSSKRRKHQGTIQRHWEYICNHNKENTKILGDENVDPICEDSENKFEFSVMSYNILSQDLLEDNSHLYKHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFYRRDVPLLDRDNVGLVLLLQPKIPSATSPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGRFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKPDGDLTQPELDKTEVLVTAEKLSSNLQHHFSLSSVYSHYLPDTGIPEVTTCHSRSAVTVDYIFYSAEKEGVAEQPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL", "length": 659, "header": "tr|A0AAF6YL90-1|A0AAF6YL90_BOVIN Isoform 1 of Angel homolog 2 OS=Bos taurus OX=9913 GN=ANGEL2 PE=4 SV=1 CANONICAL=A0AAF6YL90-1" }, "locus": { "chromosome": "16", "start_pos": 70596309, "end_pos": 70580346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004825.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004825.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004825.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004825.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "RNA 2'-phosphatase activity", "id": "GO:0160273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160273", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "RNA 2',3'-cyclic phosphatase activity", "id": "GO:0160272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160272", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of mitotic cell cycle", "id": "GO:0045930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045930", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA stabilization", "id": "GO:0070935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070935", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "negative regulation of RNA splicing", "id": "GO:0033119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033119", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "mitochondrial mRNA 3'-end processing", "id": "GO:0090616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090616", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" }, { "name": "negative regulation of tRNA processing", "id": "GO:2000236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000236", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YL90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YL90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" }, { "id": "PF03372", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Endonuclease/exonuclease/phosphatase", "eco_id": "ECO_0000259", "start_pos": 285, "end_pos": 600, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YL90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL90" }, { "id": "PF19339", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19339" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein angel homolog 2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 138, "end_pos": 244, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 643, "end_pos": 645 }, { "start_pos": 644, "end_pos": 646 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YLH5-1", "uniprot_ac": "A0AAF6YLH5", "uniprot_id": "A0AAF6YLH5_BOVIN", "mass": { "chemical_mass": 44891.0, "monoisotopic_mass": 44891.0 }, "refseq": {}, "gene_names": [ { "name": "PIP4K2C", "type": "recommended", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "type": "recommended", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.149", "type": "synonym", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol 5-phosphate 4-kinase type II gamma", "type": "synonym", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5#function" }, { "database": "UniProtKB", "id": "ARBA00046223", "url": "https://www.uniprot.org/uniprotkb/ARBA00046223#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIP4K2C", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5", "locus": { "chromosome": "5", "start_pos": 55886481, "end_pos": 55898478, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003942", "url": "https://www.ensembl.org/id/ENSBTAG00000003942" } ] } } ], "crossref": [ { "id": "A0AAF6YLH5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YLH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23086", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23086", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23086:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23086:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01504", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01504", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "12280", "url": "https://www.rhea-db.org/rhea/12280", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55964", "url": "https://www.rhea-db.org/rhea/55964", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55992", "url": "https://www.rhea-db.org/rhea/55992", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSSVPPTAVPAATAAPGAGFGFASKTKKKHFVQQKINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRSPPTESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDSEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEDGPVREEESEGDGDCGLTGPPAPVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA", "length": 400, "header": "tr|A0AAF6YLH5-1|A0AAF6YLH5_BOVIN Isoform 1 of Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Bos taurus OX=9913 GN=PIP4K2C PE=4 SV=1 CANONICAL=A0AAF6YLH5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YLH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5/entry", "sequence": { "sequence": "MASSSVPPTAVPAATAAPGAGFGFASKTKKKHFVQQKINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRSPPTESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDSEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEDGPVREEESEGDGDCGLTGPPAPVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA", "length": 400, "header": "tr|A0AAF6YLH5-1|A0AAF6YLH5_BOVIN Isoform 1 of Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Bos taurus OX=9913 GN=PIP4K2C PE=4 SV=1 CANONICAL=A0AAF6YLH5-1" }, "locus": { "chromosome": "5", "start_pos": 55898354, "end_pos": 55888284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005146.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005146.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005146.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005146.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "positive regulation of autophagosome assembly", "id": "GO:2000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "id": "GO:1902635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902635", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "1-phosphatidylinositol-5-phosphate 4-kinase activity", "id": "GO:0016309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016309", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "id": "GO:0016308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016308", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12280", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YLH5-1", "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "12280", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12280" } ] }, { "id": "55964", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YLH5-1", "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "55964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55964" } ] }, { "id": "55992", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YLH5-1", "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "55992", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55992" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YLH5", "gene_name": "PIP4K2C", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ] } ] }, { "uniprot_ac": "F1MHR4", "gene_name": "PIP4K2A", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MHR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHR4" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "F1MHR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHR4" } ] } ] }, { "uniprot_ac": "F1MHT2", "gene_name": "PIP4K2B", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MHT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "F1MHT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ] } ] }, { "uniprot_ac": "Q0P5F7", "gene_name": "PIP4K2C", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q0P5F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F7" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "Q0P5F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" }, { "id": "PS51455", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51455" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIPK", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 399, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.149", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "2.7.1.149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149" }, { "id": "2.7.1.149", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.149" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YLK6-1", "uniprot_ac": "A0AAF6YLK6", "uniprot_id": "A0AAF6YLK6_BOVIN", "mass": { "chemical_mass": 43152.0, "monoisotopic_mass": 43152.0 }, "refseq": {}, "gene_names": [ { "name": "LMAN2L", "type": "recommended", "evidence": [ { "id": "A0AAF6YLK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ] } ], "protein_names": [ { "name": "Lectin, mannose binding 2 like", "type": "synonym", "evidence": [ { "id": "A0AAF6YLK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LMAN2L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6", "locus": { "chromosome": "11", "start_pos": 2683641, "end_pos": 2704325, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003975", "url": "https://www.ensembl.org/id/ENSBTAG00000003975" } ] } } ], "crossref": [ { "id": "A0AAF6YLK6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YLK6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12223:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12223:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWRTGRAFNEGRAVGKMAVALGPSGWWQRWRRRLSAREVSRMLLLLLLLGSGQGPRQVGAGQTFEYLKREHSLSKPYQGVGTSSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFRIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQDQSRKRFY", "length": 376, "header": "tr|A0AAF6YLK6-1|A0AAF6YLK6_BOVIN Isoform 1 of Lectin, mannose binding 2 like OS=Bos taurus OX=9913 GN=LMAN2L PE=4 SV=1 CANONICAL=A0AAF6YLK6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YLK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6/entry", "sequence": { "sequence": "MAWRTGRAFNEGRAVGKMAVALGPSGWWQRWRRRLSAREVSRMLLLLLLLGSGQGPRQVGAGQTFEYLKREHSLSKPYQGVGTSSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFRIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQDQSRKRFY", "length": 376, "header": "tr|A0AAF6YLK6-1|A0AAF6YLK6_BOVIN Isoform 1 of Lectin, mannose binding 2 like OS=Bos taurus OX=9913 GN=LMAN2L PE=4 SV=1 CANONICAL=A0AAF6YLK6-1" }, "locus": { "chromosome": "11", "start_pos": 2704126, "end_pos": 2686449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005195.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005195.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005195.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005195.5" } ] } }, { "isoform_ac": "A0AAF6ZHL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHL5/entry", "sequence": { "sequence": "MAWRTGRAFNEGRAVGKMAVALGPSGWWQRWRRRLSAREVSRMLLLLLLLGSGQGPRQVGAGQTFEYLKREHSLSKPYQGVGTSSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFRIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQERVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQDQSRKRFY", "length": 365, "header": "tr|A0AAF6ZHL5-1|A0AAF6ZHL5_BOVIN Computationally mapped isoform of Lectin, mannose binding 2 like OS=Bos taurus OX=9913 GN=LMAN2L PE=4 SV=1 CANONICAL=A0AAF6YLK6-1" }, "locus": { "chromosome": "11", "start_pos": 2704126, "end_pos": 2686449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049716.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049716.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046571.3", "url": "https://www.ensembl.org/id/ENSBTAP00000046571.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YLK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YLK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLK6" }, { "id": "PS51328", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51328" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "L-type lectin-like", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 302, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 209, "end_pos": 211 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YM21-1", "uniprot_ac": "A0AAF6YM21", "uniprot_id": "A0AAF6YM21_BOVIN", "mass": { "chemical_mass": 30495.0, "monoisotopic_mass": 30495.0 }, "refseq": {}, "gene_names": [ { "name": "NDUFA8", "type": "recommended", "evidence": [ { "id": "A0AAF6YM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "type": "recommended", "evidence": [ { "id": "A0AAF6YM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21/entry#names_and_taxonomy" } ] }, { "name": "Complex I-19kD", "type": "synonym", "evidence": [ { "id": "A0AAF6YM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21/entry#names_and_taxonomy" } ] }, { "name": "NADH-ubiquinone oxidoreductase 19 kDa subunit", "type": "synonym", "evidence": [ { "id": "A0AAF6YM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21#function" }, { "database": "UniProtKB", "id": "ARBA00003195", "url": "https://www.uniprot.org/uniprotkb/ARBA00003195#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21", "locus": { "chromosome": "11", "start_pos": 93028897, "end_pos": 93047209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004295", "url": "https://www.ensembl.org/id/ENSBTAG00000004295" } ] } } ], "crossref": [ { "id": "A0AAF6YM21", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YM21", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13344:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13344:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06747", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06747", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPVSSVQSLGHLRLSASCLTMTTRRDGRGREEAPPLGTGNFPALRRLRGLWLGKAVRLRAAAAAPAQTLGGLRVRKGSSRRRGRRGSGHLLGVAATAIMPGIVELPSLEDLKVQEVKVSSSVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNQCALEFFRQIKRHCAEPFTEYWTCIDYSGLQLFRRCRKQQAQFDECVLDKLGWVRPDLGDLSKVTKVKTDRPLPENPYHSRARPEPNPEVEGDLKPARHGSRLFFWTM", "length": 271, "header": "tr|A0AAF6YM21-1|A0AAF6YM21_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Bos taurus OX=9913 GN=NDUFA8 PE=3 SV=1 CANONICAL=A0AAF6YM21-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21/entry", "sequence": { "sequence": "MAPVSSVQSLGHLRLSASCLTMTTRRDGRGREEAPPLGTGNFPALRRLRGLWLGKAVRLRAAAAAPAQTLGGLRVRKGSSRRRGRRGSGHLLGVAATAIMPGIVELPSLEDLKVQEVKVSSSVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNQCALEFFRQIKRHCAEPFTEYWTCIDYSGLQLFRRCRKQQAQFDECVLDKLGWVRPDLGDLSKVTKVKTDRPLPENPYHSRARPEPNPEVEGDLKPARHGSRLFFWTM", "length": 271, "header": "tr|A0AAF6YM21-1|A0AAF6YM21_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Bos taurus OX=9913 GN=NDUFA8 PE=3 SV=1 CANONICAL=A0AAF6YM21-1" }, "locus": { "chromosome": "11", "start_pos": 93047010, "end_pos": 93029079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005628.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005628.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005628.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005628.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YM21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM21" }, { "id": "PF06747", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06747" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000259", "start_pos": 177, "end_pos": 210, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YM48-1", "uniprot_ac": "A0AAF6YM48", "uniprot_id": "A0AAF6YM48_BOVIN", "mass": { "chemical_mass": 25904.0, "monoisotopic_mass": 25904.0 }, "refseq": {}, "gene_names": [ { "name": "CD320", "type": "recommended", "evidence": [ { "id": "A0AAF6YM48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48" } ] } ], "protein_names": [ { "name": "CD320 molecule", "type": "synonym", "evidence": [ { "id": "A0AAF6YM48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD320", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48", "locus": { "chromosome": "7", "start_pos": 16952111, "end_pos": 16957071, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004403", "url": "https://www.ensembl.org/id/ENSBTAG00000004403" } ] } } ], "crossref": [ { "id": "A0AAF6YM48", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YM48", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YM48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGWVARGLARRAAALGLGLRVLLCFGLCLEIAPTPIQTWSPTQAPGPSAGSCPPTNFQCRSDGRCLPLIWRCDVDQDCPDGSDEEECGTEVPNGSPSPCDIMDDCPDHNKNLLNCGPQSCPEGELCCPLDGVCIPSTWLCDGHRDCSDYSDELGCGTKTHEEGRTMSTGTPVTLENVTYLSNATVTAIEDWDSVQSGNRNVYGIIAARCSASVWLLASCLRCPGFVPRDAWPRWDCWCP", "length": 240, "header": "tr|A0AAF6YM48-1|A0AAF6YM48_BOVIN Isoform 1 of CD320 molecule OS=Bos taurus OX=9913 GN=CD320 PE=4 SV=1 CANONICAL=A0AAF6YM48-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48/entry", "sequence": { "sequence": "MNGWVARGLARRAAALGLGLRVLLCFGLCLEIAPTPIQTWSPTQAPGPSAGSCPPTNFQCRSDGRCLPLIWRCDVDQDCPDGSDEEECGTEVPNGSPSPCDIMDDCPDHNKNLLNCGPQSCPEGELCCPLDGVCIPSTWLCDGHRDCSDYSDELGCGTKTHEEGRTMSTGTPVTLENVTYLSNATVTAIEDWDSVQSGNRNVYGIIAARCSASVWLLASCLRCPGFVPRDAWPRWDCWCP", "length": 240, "header": "tr|A0AAF6YM48-1|A0AAF6YM48_BOVIN Isoform 1 of CD320 molecule OS=Bos taurus OX=9913 GN=CD320 PE=4 SV=1 CANONICAL=A0AAF6YM48-1" }, "locus": { "chromosome": "7", "start_pos": 16957009, "end_pos": 16952712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005777.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005777.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005777.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005777.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YM64-1", "uniprot_ac": "A0AAF6YM64", "uniprot_id": "A0AAF6YM64_BOVIN", "mass": { "chemical_mass": 19530.0, "monoisotopic_mass": 19530.0 }, "refseq": {}, "gene_names": [ { "name": "H2AZ1", "type": "recommended", "evidence": [ { "id": "A0AAF6YM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ] } ], "protein_names": [ { "name": "Histone H2A", "type": "recommended", "evidence": [ { "id": "A0AAF6YM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "H2AZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64", "locus": { "chromosome": "6", "start_pos": 24739542, "end_pos": 24736589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004428", "url": "https://www.ensembl.org/id/ENSBTAG00000004428" } ] } } ], "crossref": [ { "id": "A0AAF6YM64", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YM64", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00074", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00074", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16211", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16211", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRVSRKSTPGLGRRLWTGRSLPSRCSFGRGGQEVGRARPRGDFTWSPESEFEMAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV", "length": 181, "header": "tr|A0AAF6YM64-1|A0AAF6YM64_BOVIN Isoform 1 of Histone H2A OS=Bos taurus OX=9913 GN=H2AZ1 PE=3 SV=1 CANONICAL=A0AAF6YM64-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64/entry", "sequence": { "sequence": "MLRVSRKSTPGLGRRLWTGRSLPSRCSFGRGGQEVGRARPRGDFTWSPESEFEMAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV", "length": 181, "header": "tr|A0AAF6YM64-1|A0AAF6YM64_BOVIN Isoform 1 of Histone H2A OS=Bos taurus OX=9913 GN=H2AZ1 PE=3 SV=1 CANONICAL=A0AAF6YM64-1" }, "locus": { "chromosome": "6", "start_pos": 24739021, "end_pos": 24736652, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005802.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005802.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005802.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005802.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "euchromatin", "id": "GO:0000791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000791", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "cellular response to estradiol stimulus", "id": "GO:0071392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071392", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "RNA polymerase II core promoter sequence-specific DNA binding", "id": "GO:0000979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "nucleosomal DNA binding", "id": "GO:0031492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031492", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" }, { "id": "PF00125", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Core Histone H2A/H2B/H3", "eco_id": "ECO_0000259", "start_pos": 62, "end_pos": 146, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM64" }, { "id": "PF16211", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone H2A C-terminal", "eco_id": "ECO_0000259", "start_pos": 148, "end_pos": 179, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YM87-1", "uniprot_ac": "A0AAF6YM87", "uniprot_id": "A0AAF6YM87_BOVIN", "mass": { "chemical_mass": 39839.0, "monoisotopic_mass": 39839.0 }, "refseq": { "ac": "XP_005203185", "name": "nuclear migration protein nudC isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203185" }, "gene_names": [ { "name": "NUDC", "type": "recommended", "evidence": [ { "id": "A0AAF6YM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ] }, { "name": "NUDC", "type": "synonym", "evidence": [ { "id": "XP_005203185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203185" } ] } ], "protein_names": [ { "name": "Nuclear migration protein nudC", "type": "recommended", "evidence": [ { "id": "A0AAF6YM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87/entry#names_and_taxonomy" } ] }, { "name": "Nuclear distribution protein C homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6YM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87/entry#names_and_taxonomy" } ] }, { "name": "nuclear migration protein nudC isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005203185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203185" } ] } ], "function": [ { "annotation": "Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87#function" }, { "database": "UniProtKB", "id": "ARBA00046142", "url": "https://www.uniprot.org/uniprotkb/ARBA00046142#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDC", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87", "locus": { "chromosome": "2", "start_pos": 126273271, "end_pos": 126286709, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004416", "url": "https://www.ensembl.org/id/ENSBTAG00000004416" } ] } } ], "crossref": [ { "id": "A0AAF6YM87", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YM87", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06492", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06492", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513277", "url": "https://www.ncbi.nlm.nih.gov/gene/513277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12356:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12356:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04969", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04969", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14050", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14050", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203185", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203185", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGEQEEDRFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFVGGEEGMAEKLITQTFNHHNQLAQKARREKRARQETERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENQEAQLKNGSLGSPGKQSGSVREAAEHPNCEQEAEEEEEEDDEKDKGKLKPNLGNGADLPSYRWTQTLSELDLAVPFCVNFRLKGKDVVVDIQRRHLRVGLKGQPAIVDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKARFN", "length": 347, "header": "tr|A0AAF6YM87-1|A0AAF6YM87_BOVIN Isoform 1 of Nuclear migration protein nudC OS=Bos taurus OX=9913 GN=NUDC PE=3 SV=1 CANONICAL=A0AAF6YM87-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87/entry", "sequence": { "sequence": "MGGEQEEDRFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFVGGEEGMAEKLITQTFNHHNQLAQKARREKRARQETERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENQEAQLKNGSLGSPGKQSGSVREAAEHPNCEQEAEEEEEEDDEKDKGKLKPNLGNGADLPSYRWTQTLSELDLAVPFCVNFRLKGKDVVVDIQRRHLRVGLKGQPAIVDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKARFN", "length": 347, "header": "tr|A0AAF6YM87-1|A0AAF6YM87_BOVIN Isoform 1 of Nuclear migration protein nudC OS=Bos taurus OX=9913 GN=NUDC PE=3 SV=1 CANONICAL=A0AAF6YM87-1" }, "locus": { "chromosome": "2", "start_pos": 126286602, "end_pos": 126273490, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005789.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005789.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005789.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005789.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" }, { "name": "mitotic metaphase chromosome alignment", "id": "GO:0007080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007080", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM87" }, { "id": "PS51203", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51203" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CS", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 274, "start_aa": "Ala", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YME1-1", "uniprot_ac": "A0AAF6YME1", "uniprot_id": "A0AAF6YME1_BOVIN", "mass": { "chemical_mass": 72215.0, "monoisotopic_mass": 72215.0 }, "refseq": {}, "gene_names": [ { "name": "RHOT2", "type": "recommended", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ], "protein_names": [ { "name": "Mitochondrial Rho GTPase", "type": "recommended", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.-", "type": "synonym", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1#function" }, { "database": "UniProtKB", "id": "PIRNR037488", "url": "https://www.uniprot.org/uniprotkb/PIRNR037488#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHOT2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1", "locus": { "chromosome": "25", "start_pos": 578925, "end_pos": 423414, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004551", "url": "https://www.ensembl.org/id/ENSBTAG00000004551" } ] } } ], "crossref": [ { "id": "A0AAF6YME1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YME1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01892", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01892", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01893", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01893", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46819", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46819", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46819:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46819:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08356", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08356", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "64900", "url": "https://www.rhea-db.org/rhea/64900", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YME1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSETEQTVEELQGEIDKADVVCVVYDVSEEATVEKIRTKWIPLVNGDTKRGPRVPIILVGNKSDLRPGGSMEAVLPIMSQFPEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDMDQALSDQELNAFQTSCFGHPLAPQALEDVKMVVSKNVVGGVRDDQLTLDGFLFLNTLFIQRGRHETTWTILRRFGYGDSLELTADYLCPPLRVPPGCSAELNHRGYQFVQRMFEKHDQDRDGALSPAELQSLFSVFPAAPWGPHLPSTVRTKAGRLPLHGYLCQWTLVTYLDVRRSLEHLGYLGYPTLCEQDSQAHAITVTREKRLDQEKGQTQRNVLLCKVVGARGVGKSSFLRAFLGHSLGHQDAGEPSVYAIDTVQVNGQEKYLILCEVAADSLLTASADASCDVACLMFDGSDLRSFALCASVYKQHYMDGQTPCLFVCSKADLPGGVPLPGLSPAEFCRRHRLPTPTLFSCAGPVEPCMGIFTRLATMATFPWTPCPRAAAGHLLLAPGGSGGHGGCRRCHPQLLPLQGPGEEPMRPRAPWSISGCWGGRAPPGLRFPPEDSPPLLCPCPAHR", "length": 658, "header": "tr|A0AAF6YME1-1|A0AAF6YME1_BOVIN Isoform 1 of Mitochondrial Rho GTPase OS=Bos taurus OX=9913 GN=RHOT2 PE=3 SV=1 CANONICAL=A0AAF6YME1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YME1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1/entry", "sequence": { "sequence": "MKRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSETEQTVEELQGEIDKADVVCVVYDVSEEATVEKIRTKWIPLVNGDTKRGPRVPIILVGNKSDLRPGGSMEAVLPIMSQFPEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDMDQALSDQELNAFQTSCFGHPLAPQALEDVKMVVSKNVVGGVRDDQLTLDGFLFLNTLFIQRGRHETTWTILRRFGYGDSLELTADYLCPPLRVPPGCSAELNHRGYQFVQRMFEKHDQDRDGALSPAELQSLFSVFPAAPWGPHLPSTVRTKAGRLPLHGYLCQWTLVTYLDVRRSLEHLGYLGYPTLCEQDSQAHAITVTREKRLDQEKGQTQRNVLLCKVVGARGVGKSSFLRAFLGHSLGHQDAGEPSVYAIDTVQVNGQEKYLILCEVAADSLLTASADASCDVACLMFDGSDLRSFALCASVYKQHYMDGQTPCLFVCSKADLPGGVPLPGLSPAEFCRRHRLPTPTLFSCAGPVEPCMGIFTRLATMATFPWTPCPRAAAGHLLLAPGGSGGHGGCRRCHPQLLPLQGPGEEPMRPRAPWSISGCWGGRAPPGLRFPPEDSPPLLCPCPAHR", "length": 658, "header": "tr|A0AAF6YME1-1|A0AAF6YME1_BOVIN Isoform 1 of Mitochondrial Rho GTPase OS=Bos taurus OX=9913 GN=RHOT2 PE=3 SV=1 CANONICAL=A0AAF6YME1-1" }, "locus": { "chromosome": "25", "start_pos": 578383, "end_pos": 573493, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005979.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005979.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005979.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005979.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrion transport along microtubule", "id": "GO:0047497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047497", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "cellular homeostasis", "id": "GO:0019725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019725", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "mitochondrial outer membrane permeabilization", "id": "GO:0097345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097345", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YME1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "64900", "name": "", "equation": "UTP + H2O = UDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB25-1", "O18956-1", "Q2HJF8-1", "Q5E9M9-1", "A0JND9-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "G3MZH7-1", "A0AAF6YME1-1" ], "evidence": [ { "id": "64900", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/64900" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 304, "end_pos": 339, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" }, { "id": "PS51423", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51423" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Miro", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 168, "start_aa": "Lys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 154, "end_pos": 156 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YMV1-1", "uniprot_ac": "A0AAF6YMV1", "uniprot_id": "A0AAF6YMV1_BOVIN", "mass": { "chemical_mass": 47808.0, "monoisotopic_mass": 47808.0 }, "refseq": {}, "gene_names": [ { "name": "KRT19", "type": "recommended", "evidence": [ { "id": "A0AAF6YMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ] } ], "protein_names": [ { "name": "Keratin, type I cytoskeletal 19", "type": "recommended", "evidence": [ { "id": "A0AAF6YMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1/entry#names_and_taxonomy" } ] }, { "name": "Cytokeratin-19", "type": "synonym", "evidence": [ { "id": "A0AAF6YMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1/entry#names_and_taxonomy" } ] }, { "name": "Keratin-19", "type": "synonym", "evidence": [ { "id": "A0AAF6YMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1#function" }, { "database": "UniProtKB", "id": "ARBA00037562", "url": "https://www.uniprot.org/uniprotkb/ARBA00037562#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1", "locus": { "chromosome": "19", "start_pos": 41731623, "end_pos": 41736234, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004905", "url": "https://www.ensembl.org/id/ENSBTAG00000004905" } ] } } ], "crossref": [ { "id": "A0AAF6YMV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YMV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYAFGVGGHKRRQVRASRHSSCGRTAATPTGAASSCFAMTSYSYRQSSSTSSFGGMGGGSMRFGAGGAFRAPSIHGGSGGRGVSVSSARFVSSSSGGYGGGYGGALATSDGLLAGNEKLTMQNLNDRLASYLEKVRALEEANGDLEVKIRDWYQKQGPGPARDYSHYFKTIEDLRDQILGATIENSKIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEMSVLKGQVGGQVSVEVDSAPGIDLAKILSDMRSQYEVIAEKNRKDAEAWFISQTEELNREVAGHTEQLQISKTEVTDLRRTLQGLEIELQSQLSMKAALEGTLAETEARFGAQLAQIQALISGIEAQLSDVRADTERQNQEYQHLMDIKTRLEQEIATYRNLLEGQDAYFNDLSLAKAL", "length": 437, "header": "tr|A0AAF6YMV1-1|A0AAF6YMV1_BOVIN Isoform 1 of Keratin, type I cytoskeletal 19 OS=Bos taurus OX=9913 GN=KRT19 PE=3 SV=1 CANONICAL=A0AAF6YMV1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1/entry", "sequence": { "sequence": "MYAFGVGGHKRRQVRASRHSSCGRTAATPTGAASSCFAMTSYSYRQSSSTSSFGGMGGGSMRFGAGGAFRAPSIHGGSGGRGVSVSSARFVSSSSGGYGGGYGGALATSDGLLAGNEKLTMQNLNDRLASYLEKVRALEEANGDLEVKIRDWYQKQGPGPARDYSHYFKTIEDLRDQILGATIENSKIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEMSVLKGQVGGQVSVEVDSAPGIDLAKILSDMRSQYEVIAEKNRKDAEAWFISQTEELNREVAGHTEQLQISKTEVTDLRRTLQGLEIELQSQLSMKAALEGTLAETEARFGAQLAQIQALISGIEAQLSDVRADTERQNQEYQHLMDIKTRLEQEIATYRNLLEGQDAYFNDLSLAKAL", "length": 437, "header": "tr|A0AAF6YMV1-1|A0AAF6YMV1_BOVIN Isoform 1 of Keratin, type I cytoskeletal 19 OS=Bos taurus OX=9913 GN=KRT19 PE=3 SV=1 CANONICAL=A0AAF6YMV1-1" }, "locus": { "chromosome": "19", "start_pos": 41736231, "end_pos": 41731756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006450.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006450.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006450.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006450.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" }, { "name": "costamere", "id": "GO:0043034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043034", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" }, { "name": "apicolateral plasma membrane", "id": "GO:0016327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016327", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" }, { "name": "terminal web", "id": "GO:1990357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990357", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of muscle", "id": "GO:0008307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008307", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "response to estrogen", "id": "GO:0043627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMV1" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 117, "end_pos": 428, "start_aa": "Glu", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YMX3-1", "uniprot_ac": "A0AAF6YMX3", "uniprot_id": "A0AAF6YMX3_BOVIN", "mass": { "chemical_mass": 53805.0, "monoisotopic_mass": 53805.0 }, "refseq": {}, "gene_names": [ { "name": "CDK9", "type": "recommended", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ], "protein_names": [ { "name": "Cyclin-dependent kinase 9", "type": "recommended", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.22", "type": "synonym", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.23", "type": "synonym", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3/entry#names_and_taxonomy" } ] }, { "name": "Cell division protein kinase 9", "type": "synonym", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDK9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3", "locus": { "chromosome": "11", "start_pos": 98466335, "end_pos": 98461408, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004695", "url": "https://www.ensembl.org/id/ENSBTAG00000004695" } ] } } ], "crossref": [ { "id": "A0AAF6YMX3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YMX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07865", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07865", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24056", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24056", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24056:SF233", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24056:SF233", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10216", "url": "https://www.rhea-db.org/rhea/10216", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRDAPPRAPAPAPRLPAPPIGAAAGASGGGGGGSGGGGGASAASAPPGLPGTTSPRGPGGGRRAEEAGSAPRGRKWPWRRKWRGRGGAWSTAAGPGAGAAAAAAAAAVVAGSGGGGVLESAMAKQYDSVECPFCDEVTKYEKLAKIGQGTFGEVFKAKHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKVELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF", "length": 494, "header": "tr|A0AAF6YMX3-1|A0AAF6YMX3_BOVIN Isoform 1 of Cyclin-dependent kinase 9 OS=Bos taurus OX=9913 GN=CDK9 PE=3 SV=1 CANONICAL=A0AAF6YMX3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YMX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3/entry", "sequence": { "sequence": "MQRDAPPRAPAPAPRLPAPPIGAAAGASGGGGGGSGGGGGASAASAPPGLPGTTSPRGPGGGRRAEEAGSAPRGRKWPWRRKWRGRGGAWSTAAGPGAGAAAAAAAAAVVAGSGGGGVLESAMAKQYDSVECPFCDEVTKYEKLAKIGQGTFGEVFKAKHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKVELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF", "length": 494, "header": "tr|A0AAF6YMX3-1|A0AAF6YMX3_BOVIN Isoform 1 of Cyclin-dependent kinase 9 OS=Bos taurus OX=9913 GN=CDK9 PE=3 SV=1 CANONICAL=A0AAF6YMX3-1" }, "locus": { "chromosome": "11", "start_pos": 98465764, "end_pos": 98461607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006162.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006162.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006162.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006162.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "7SK snRNA binding", "id": "GO:0097322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097322", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0004693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "RNA polymerase II CTD heptapeptide repeat kinase activity", "id": "GO:0008353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008353", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "transcription elongation factor activity", "id": "GO:0003711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003711", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "histone H1-4S187 kinase activity", "id": "GO:0140191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140191", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "P-TEFb complex", "id": "GO:0070691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070691", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "cellular response to cytokine stimulus", "id": "GO:0071345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071345", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "host-mediated activation of viral transcription", "id": "GO:0043923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043923", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "positive regulation of transcription elongation by RNA polymerase II", "id": "GO:0032968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "nucleus localization", "id": "GO:0051647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051647", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "regulation of DNA repair", "id": "GO:0006282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006282", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "regulation of muscle cell differentiation", "id": "GO:0051147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051147", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "regulation of mRNA 3'-end processing", "id": "GO:0031440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031440", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "negative regulation of protein localization to chromatin", "id": "GO:0120186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120186", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "positive regulation of protein localization to chromatin", "id": "GO:0120187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120187", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" }, { "name": "transcription elongation-coupled chromatin remodeling", "id": "GO:0140673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140673", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YMX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10216", "name": "", "equation": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E518-1", "P48734-1", "A0A3Q1LNU2-1", "E1BB50-1", "E1BB52-1", "Q5EAB2-1", "F1MPI8-1", "A0AAF6YMX3-1", "F1N5K1-1" ], "evidence": [ { "id": "10216", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10216" } ] }, { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 437, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.22", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22" }, { "id": "2.7.11.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.22" } ] }, { "ec_number": "2.7.11.23", "ec_name": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "2.7.11.23", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23" }, { "id": "2.7.11.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.23" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 477, "end_pos": 479 }, { "start_pos": 486, "end_pos": 488 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YN08-1", "uniprot_ac": "A0AAF6YN08", "uniprot_id": "A0AAF6YN08_BOVIN", "mass": { "chemical_mass": 21557.0, "monoisotopic_mass": 21557.0 }, "refseq": {}, "gene_names": [ { "name": "ABITRAM", "type": "recommended", "evidence": [ { "id": "A0AAF6YN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ] } ], "protein_names": [ { "name": "Protein Abitram", "type": "recommended", "evidence": [ { "id": "A0AAF6YN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08/entry#names_and_taxonomy" } ] }, { "name": "Actin-binding transcription modulator", "type": "synonym", "evidence": [ { "id": "A0AAF6YN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08/entry#names_and_taxonomy" } ] }, { "name": "Protein Simiate", "type": "synonym", "evidence": [ { "id": "A0AAF6YN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABITRAM", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08", "locus": { "chromosome": "8", "start_pos": 98543210, "end_pos": 98536727, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004996", "url": "https://www.ensembl.org/id/ENSBTAG00000004996" } ] } } ], "crossref": [ { "id": "A0AAF6YN08", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YN08", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13651", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13651", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13651:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13651:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01597", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01597", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LPSPRTLWPTWLPSLRCRRLWIVTLLAGTKQTHSFLLDVKGKPCEDHCILQHSNRICVITLAGSHPVLQSGKTIKSISYQISTNCSRLQNKVSGKFKRGAQFLTELAPLCKIYCSDGEEYTISSCVRGRLMEVNENILHKPSILQEKPSTEGYIAVVLPKFEESKSITEGLLTQKEYEEVVVKRLRATTAAS", "length": 192, "header": "tr|A0AAF6YN08-1|A0AAF6YN08_BOVIN Isoform 1 of Protein Abitram OS=Bos taurus OX=9913 GN=ABITRAM PE=3 SV=2 CANONICAL=A0AAF6YN08-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YN08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08/entry", "sequence": { "sequence": "LPSPRTLWPTWLPSLRCRRLWIVTLLAGTKQTHSFLLDVKGKPCEDHCILQHSNRICVITLAGSHPVLQSGKTIKSISYQISTNCSRLQNKVSGKFKRGAQFLTELAPLCKIYCSDGEEYTISSCVRGRLMEVNENILHKPSILQEKPSTEGYIAVVLPKFEESKSITEGLLTQKEYEEVVVKRLRATTAAS", "length": 192, "header": "tr|A0AAF6YN08-1|A0AAF6YN08_BOVIN Isoform 1 of Protein Abitram OS=Bos taurus OX=9913 GN=ABITRAM PE=3 SV=2 CANONICAL=A0AAF6YN08-1" }, "locus": { "chromosome": "8", "start_pos": 98542285, "end_pos": 98536731, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006575.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006575.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006575.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006575.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "filopodium tip", "id": "GO:0032433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032433", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "dendrite morphogenesis", "id": "GO:0048813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "regulation of filopodium assembly", "id": "GO:0051489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051489", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" }, { "name": "regulation of actin filament polymerization", "id": "GO:0030833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030833", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YN19-1", "uniprot_ac": "A0AAF6YN19", "uniprot_id": "A0AAF6YN19_BOVIN", "mass": { "chemical_mass": 63793.0, "monoisotopic_mass": 63793.0 }, "refseq": { "ac": "XP_005225001", "name": "HIRA-interacting protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225001" }, "gene_names": [ { "name": "HIRIP3", "type": "recommended", "evidence": [ { "id": "A0AAF6YN19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ] }, { "name": "HIRIP3", "type": "synonym", "evidence": [ { "id": "XP_005225001", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225001" } ] } ], "protein_names": [ { "name": "HIRA interacting protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6YN19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19/entry#names_and_taxonomy" } ] }, { "name": "HIRA-interacting protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225001", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225001" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIRIP3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19", "locus": { "chromosome": "25", "start_pos": 26271508, "end_pos": 26267918, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005028", "url": "https://www.ensembl.org/id/ENSBTAG00000005028" } ] } } ], "crossref": [ { "id": "A0AAF6YN19", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YN19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005028", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005028", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539704", "url": "https://www.ncbi.nlm.nih.gov/gene/539704", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037647", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037647", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539704", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539704", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NEMQEFT", "url": "https://omabrowser.org/oma/group/NEMQEFT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAW7", "url": "https://www.orthodb.org/?gene=E1BAW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15410", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15410", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15410:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15410:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09649", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09649", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225001", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225001", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAW7", "url": "https://www.uniprot.org/uniprotkb/E1BAW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARENEMQEFTRSFFQGHPDLSTLTHSIVRRRFLAHAGRDHLEPEEKQALKRLVEEELLKMQVDEASAKQERLHVGKKAKRSPAPCRDPERKRFRFNSESEPSSAASSPDRLNPSAKNGMAADVTPAEDESPNQASKKATESSDDEQQRDLTAKIRLEKEVVKESSEEEEEGSARKRKVWKEESSEEEEEEGKESKGRTRKKPGTKTKQAPGKASGSRKQAKEESEDSEEDPAQGRGKKGAKSHQGSAKESEEEEETVTKNKENREEEEDWKPTDQSSGGKRSVREERSCKQKSRAARLLGERGDREEQKEKAAASSGDSSEEDEVPLVQRKRKDRTQGKDGKRQSGSSEEDGEDSPRKVKPTTGKTAKEGSISGEASDSEKEVSDSEAEGSPKKERKNRSSKKSSKKGRTRSPSSSSIDGSPEHKGRKAGSGRSGEDHPAVRRLKRYIRACGAHRNYKKLLGSCRSRKERLSVLRAELEALGMKGNPSLEKCRALKEQREEAAEVASLDITNIISSSGRPRRRTAWNPSGETAPPGELYRRILDSDEERPHPPPPDWSHLRGIISSDGESN", "length": 572, "header": "tr|A0AAF6YN19-1|A0AAF6YN19_BOVIN Isoform 1 of HIRA interacting protein 3 OS=Bos taurus OX=9913 GN=HIRIP3 PE=4 SV=1 CANONICAL=A0AAF6YN19-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YN19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19/entry", "sequence": { "sequence": "MARENEMQEFTRSFFQGHPDLSTLTHSIVRRRFLAHAGRDHLEPEEKQALKRLVEEELLKMQVDEASAKQERLHVGKKAKRSPAPCRDPERKRFRFNSESEPSSAASSPDRLNPSAKNGMAADVTPAEDESPNQASKKATESSDDEQQRDLTAKIRLEKEVVKESSEEEEEGSARKRKVWKEESSEEEEEEGKESKGRTRKKPGTKTKQAPGKASGSRKQAKEESEDSEEDPAQGRGKKGAKSHQGSAKESEEEEETVTKNKENREEEEDWKPTDQSSGGKRSVREERSCKQKSRAARLLGERGDREEQKEKAAASSGDSSEEDEVPLVQRKRKDRTQGKDGKRQSGSSEEDGEDSPRKVKPTTGKTAKEGSISGEASDSEKEVSDSEAEGSPKKERKNRSSKKSSKKGRTRSPSSSSIDGSPEHKGRKAGSGRSGEDHPAVRRLKRYIRACGAHRNYKKLLGSCRSRKERLSVLRAELEALGMKGNPSLEKCRALKEQREEAAEVASLDITNIISSSGRPRRRTAWNPSGETAPPGELYRRILDSDEERPHPPPPDWSHLRGIISSDGESN", "length": 572, "header": "tr|A0AAF6YN19-1|A0AAF6YN19_BOVIN Isoform 1 of HIRA interacting protein 3 OS=Bos taurus OX=9913 GN=HIRIP3 PE=4 SV=1 CANONICAL=A0AAF6YN19-1" }, "locus": { "chromosome": "25", "start_pos": 26271191, "end_pos": 26268568, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006625.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006625.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006625.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006625.7" } ] } }, { "isoform_ac": "E1BAW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAW7/entry", "sequence": { "sequence": "MARENEMQEFTRSFFQGHPDLSTLTHSIVRRRFLAHAGRDHLEPEEKQALKRLVEEELLKMQVDEASAKQERLHVGKKAKRSPAPCRDPERKRFRFNSESEPSSAASSPDRLNPSAKNGMAADVTPAEDESPNQASKKATESSDDEQQRDLTAKIRLEKEEEEGKESKGRTRKKPGTKTKQAPGKASGSRKQAKEESEDSEEDPAQGRGKKGAKSHQGSAKESEEEEETVTKNKENREEEEDWKPTDQSSGGKRSVREERSCKQKSRAARLLGERGDREEQKEKAAASSGDSSEEDEVPLVQRKRKDRTQGKDGKRQSGSSEEDGEDSPRKVKPTTGKTAKEGSISGEASDSEKEVSDSEAEGSPKKERKNRSSKKSSKKGRTRSPSSSSIDGSPEHKGRKAGSGRSGEDHPAVRRLKRYIRACGAHRNYKKLLGSCRSRKERLSVLRAELEALGMKGNPSLEKCRALKEQREEAAEVASLDITNIISSSGRPRRRTAWNPSGETAPPGELYRRILDSDEERPHPPPPDWSHLRGIISSDGESN", "length": 544, "header": "tr|E1BAW7-1|E1BAW7_BOVIN Computationally mapped isoform of HIRA interacting protein 3 OS=Bos taurus OX=9913 GN=HIRIP3 PE=4 SV=2 CANONICAL=A0AAF6YN19-1" }, "locus": { "chromosome": "25", "start_pos": 26271191, "end_pos": 26268568, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006619.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006619.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006619.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006619.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 125, "start_aa": "Thr", "end_pos": 125, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr125", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 363, "start_aa": "Thr", "end_pos": 363, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr363", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539704", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539704", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I4I2-1", "protein_name": "HIRA-interacting protein 3 isoform X1", "gene_name": "Hirip3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALGDEMLEFTRSFFRGCPDLSTVTHSIVRQKFLTHVGRDHLEPEEKQALKRLVEEELLKMQADAGTREGKLDFTKVKRSPAPCSDPERKRSRFNSESDSSSTSSSPDCSGPPRKNSTTKEKPCLKRALNKAVESKKEEQQTDLVVKMRLEESSDEEGEGSVRSNKVWEEEDTEEDDDVKKEQKGRSKKKAGAKNKQTPSRASDNQKQVSEESDSEEEAMQGRAKVRKSAGTKRHKESEDSEEETLAKKKEHREPRPRSNKGERMSYKQKNRVGRLTGGLGDSEEEKERGAVSSGDSSGTEDESSSKRKSQDKIQAENGRRPSASSEDGESSTQELTAAPGTAKTGTVGCVNSESDMEREVSDSRAGESTKEERKNRSSKKSSKKGKARSSSSDSSPEPTSQKVGSRHRREDHPAVVRLKRYIRACGAHRNYKKLLGSCRSHKECLSVLRAELEALGMKGNPSLEKCRALKEQREEAAEVASLDVANIISSSGRPRRRNAWNPSGEGIPPGELYRRALDSEEERPRQAPPDWSHMRGIISSDGESS", "length": 546 }, "evidence": [ { "id": "A0AAF6YN19", "url": "https://omabrowser.org/oma/group/A0AAF6YN19/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BLH7-1", "protein_name": "HIRA-interacting protein 3", "gene_name": "Hirip3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPGDEMRKFTRSFFRACPDLSSVTHAIVRQKFLIHVGRDHLEPEEKQALKRLVEEELPKMQADAGTREGKPDFIKVKRSPAPCSDPKKKRFRFNSESESSSSPSSPDGSGPSTKNRTTKKTCLRRALKKAVESTDEDHQTDLDAKMGLEESSEGEAEGSVRSGKVTEEEEDMKQEQKGQVRKQAGAKDKQVPLKADRKQVREESGSSEEEAVLQRAKVEGSTGANCQEESEESGEESPAKKKELSEPRSRSNRAERTARERKSYKQKSRPGRPTGGLRDSEAEKEGGTVGSGDSSEEGEAEKEGGTVGSGDSSEKGEAEKEEGTVGSGDSSEEGEEHSVKRKSKVRTQTESGRRQNTSSRDDSNSTQEQAAAQGTTKSGSLGSSNGDSDTEREVSDSQAGQNTKEERKSRSSNKSSKNGQARSCSSSSDSSPEPTGQKGKARSSSSSSDSGPEPTGRKAASRCGEDHPAVARLKRYIRACGAHRNYKKLLGSCSSHKARLSVLRAELEALGMKGNPSLEKCRALKLQREEAAEVAALDVANIISSTGRPRRRNAWNPSGEGTSPGETYRRTLDSEEEQPRQAPPDWSHMRDIISSDGDSS", "length": 601 }, "evidence": [ { "id": "A0AAF6YN19", "url": "https://omabrowser.org/oma/group/A0AAF6YN19/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BW71-1", "protein_name": "HIRA-interacting protein 3", "gene_name": "HIRIP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPPDWSHMRGIISSDGESN", "length": 556 }, "evidence": [ { "id": "A0AAF6YN19", "url": "https://omabrowser.org/oma/group/A0AAF6YN19/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "H2A-H2B histone complex chaperone activity", "id": "GO:0000511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000511", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YN19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN19" }, { "id": "SM01082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone chaperone", "eco_id": "ECO_0000259", "start_pos": 500, "end_pos": 536, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 125, 363 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 399, "end_pos": 401 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YN41-1", "uniprot_ac": "A0AAF6YN41", "uniprot_id": "A0AAF6YN41_BOVIN", "mass": { "chemical_mass": 28634.0, "monoisotopic_mass": 28634.0 }, "refseq": {}, "gene_names": [ { "name": "THEM6", "type": "recommended", "evidence": [ { "id": "A0AAF6YN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41" } ] } ], "protein_names": [ { "name": "Protein THEM6", "type": "recommended", "evidence": [ { "id": "A0AAF6YN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN41", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THEM6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41", "locus": { "chromosome": "14", "start_pos": 1694331, "end_pos": 1698013, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005063", "url": "https://www.ensembl.org/id/ENSBTAG00000005063" } ] } } ], "crossref": [ { "id": "A0AAF6YN41", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YN41", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00586", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00586", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR029069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12475", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12475", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12475:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12475:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13279", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13279", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YN41", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRSARAKLNGSQAGRQSSETSAAAATVRAEPAPALTALPRPAPATAAATMLELLVALLALALAYFALLDGWYLVRVPCAVLRARLLQPRVRDLLAEQSYAGRVLPSDLDLLLHMNNARYLREADVARIAHLTRCGVLEALRALGARAVLAASCARYRRSLRLFEPFEVRTRLLGWDDRAFYVEARFISLRDGFVCALLRSRQHVLGTSPERVVQHLCKRRVEPPELPADLQHWIAYNEASSQLLRAESGLHDILKEQ", "length": 258, "header": "tr|A0AAF6YN41-1|A0AAF6YN41_BOVIN Isoform 1 of Protein THEM6 OS=Bos taurus OX=9913 GN=THEM6 PE=3 SV=1 CANONICAL=A0AAF6YN41-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YN41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN41/entry", "sequence": { "sequence": "MVRSARAKLNGSQAGRQSSETSAAAATVRAEPAPALTALPRPAPATAAATMLELLVALLALALAYFALLDGWYLVRVPCAVLRARLLQPRVRDLLAEQSYAGRVLPSDLDLLLHMNNARYLREADVARIAHLTRCGVLEALRALGARAVLAASCARYRRSLRLFEPFEVRTRLLGWDDRAFYVEARFISLRDGFVCALLRSRQHVLGTSPERVVQHLCKRRVEPPELPADLQHWIAYNEASSQLLRAESGLHDILKEQ", "length": 258, "header": "tr|A0AAF6YN41-1|A0AAF6YN41_BOVIN Isoform 1 of Protein THEM6 OS=Bos taurus OX=9913 GN=THEM6 PE=3 SV=1 CANONICAL=A0AAF6YN41-1" }, "locus": { "chromosome": "14", "start_pos": 1697814, "end_pos": 1695686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006673.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006673.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006673.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006673.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YN64-1", "uniprot_ac": "A0AAF6YN64", "uniprot_id": "A0AAF6YN64_BOVIN", "mass": { "chemical_mass": 25246.0, "monoisotopic_mass": 25246.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Chromosome 1 C3orf70 homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6YN64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64", "locus": {} } ], "crossref": [ { "id": "A0AAF6YN64", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YN64", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31785", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31785", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31785:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31785:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15823", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15823", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YN64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVTSGTAHLMNIPWGLCHHCPCHAPASAAGEPWPTPASSGDLPKPTSKYVYQPMTPVEQLPSTEIPAKPREPANTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHKMSPEEVSAHDAFISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETIETTV", "length": 231, "header": "tr|A0AAF6YN64-1|A0AAF6YN64_BOVIN Isoform 1 of Chromosome 1 C3orf70 homolog OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YN64-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YN64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64/entry", "sequence": { "sequence": "MVTSGTAHLMNIPWGLCHHCPCHAPASAAGEPWPTPASSGDLPKPTSKYVYQPMTPVEQLPSTEIPAKPREPANTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHKMSPEEVSAHDAFISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETIETTV", "length": 231, "header": "tr|A0AAF6YN64-1|A0AAF6YN64_BOVIN Isoform 1 of Chromosome 1 C3orf70 homolog OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YN64-1" }, "locus": { "chromosome": "1", "start_pos": 82104450, "end_pos": 82084631, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006865.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006865.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006865.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006865.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YN83-1", "uniprot_ac": "A0AAF6YN83", "uniprot_id": "A0AAF6YN83_BOVIN", "mass": { "chemical_mass": 44024.0, "monoisotopic_mass": 44024.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Peroxisomal membrane protein PEX13", "type": "recommended", "evidence": [ { "id": "A0AAF6YN83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83/entry#names_and_taxonomy" } ] }, { "name": "Peroxin-13", "type": "synonym", "evidence": [ { "id": "A0AAF6YN83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83#function" }, { "database": "UniProtKB", "id": "ARBA00056165", "url": "https://www.uniprot.org/uniprotkb/ARBA00056165#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83", "locus": {} } ], "crossref": [ { "id": "A0AAF6YN83", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YN83", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11864", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11864", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19332", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19332", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19332:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19332:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04088", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04088", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGWHHRLNGHGFRWTPGVGDGQGGLASAELGPTLLTRPGQPTLTRVPPPILPRPSQQTGSGNLNTFRPAYSSFSSGYGAYGNSFYGSYSPYSYGYNGLGYNRLRIDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMIGLRRGLENEDLWAESEGTVACLGAEDRAANSAKSWPIFLFFAVILGGPYLIWKLLSTHSDEVTDSTNWASGEDDHVVARAEYDFVAVSEEEISFRAGDMLNLALKEQQPRVRGWLLASLDGQTTGLIPANYVKILGKRRGRKTVESSRISKQQQSFTNTTLIKGATAADSLDDQEAAFESVFVETNKVPVASDSTGKNGDKQDL", "length": 399, "header": "tr|A0AAF6YN83-1|A0AAF6YN83_BOVIN Isoform 1 of Peroxisomal membrane protein PEX13 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YN83-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YN83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83/entry", "sequence": { "sequence": "MVGWHHRLNGHGFRWTPGVGDGQGGLASAELGPTLLTRPGQPTLTRVPPPILPRPSQQTGSGNLNTFRPAYSSFSSGYGAYGNSFYGSYSPYSYGYNGLGYNRLRIDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQWMIGLRRGLENEDLWAESEGTVACLGAEDRAANSAKSWPIFLFFAVILGGPYLIWKLLSTHSDEVTDSTNWASGEDDHVVARAEYDFVAVSEEEISFRAGDMLNLALKEQQPRVRGWLLASLDGQTTGLIPANYVKILGKRRGRKTVESSRISKQQQSFTNTTLIKGATAADSLDDQEAAFESVFVETNKVPVASDSTGKNGDKQDL", "length": 399, "header": "tr|A0AAF6YN83-1|A0AAF6YN83_BOVIN Isoform 1 of Peroxisomal membrane protein PEX13 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YN83-1" }, "locus": { "chromosome": "11", "start_pos": 43790949, "end_pos": 43783315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006917.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006917.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006917.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006917.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein import into peroxisome matrix, translocation", "id": "GO:0016561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016561", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" } ], "pmid": "" }, { "name": "cellular response to reactive oxygen species", "id": "GO:0034614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034614", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" } ], "pmid": "" }, { "name": "protein import into peroxisome matrix, docking", "id": "GO:0016560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016560", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YN83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YN83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN83" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 268, "end_pos": 332, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 353, "end_pos": 355 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YNQ3-1", "uniprot_ac": "A0AAF6YNQ3", "uniprot_id": "A0AAF6YNQ3_BOVIN", "mass": { "chemical_mass": 29704.0, "monoisotopic_mass": 29704.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "SCAN domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6YNQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May regulate transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3#function" }, { "database": "UniProtKB", "id": "ARBA00037286", "url": "https://www.uniprot.org/uniprotkb/ARBA00037286#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3", "locus": {} } ], "crossref": [ { "id": "A0AAF6YNQ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YNQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YNQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "CKLKRSRRAKTLLRASSGLGGGFGTCSSSDPSSGSSSSSSSDSSSSDFSSNTSSKAPPSGASRGELRLVCSPAGPATSRPDVRTRGGAASGSPDPASGLLCAELIIEKAAGTPTSGRPRRFAGAGKLGTPSARLPQGRALRPVEEVPFAPPPCRRRAEPTTAGQRATRGAGVMAATEQSLAPAGSSAPPSGKEEGAGPSSGPGGSRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRLRRRTDVRITG", "length": 284, "header": "tr|A0AAF6YNQ3-1|A0AAF6YNQ3_BOVIN Isoform 1 of SCAN domain-containing protein 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6YNQ3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YNQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3/entry", "sequence": { "sequence": "CKLKRSRRAKTLLRASSGLGGGFGTCSSSDPSSGSSSSSSSDSSSSDFSSNTSSKAPPSGASRGELRLVCSPAGPATSRPDVRTRGGAASGSPDPASGLLCAELIIEKAAGTPTSGRPRRFAGAGKLGTPSARLPQGRALRPVEEVPFAPPPCRRRAEPTTAGQRATRGAGVMAATEQSLAPAGSSAPPSGKEEGAGPSSGPGGSRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRLRRRTDVRITG", "length": 284, "header": "tr|A0AAF6YNQ3-1|A0AAF6YNQ3_BOVIN Isoform 1 of SCAN domain-containing protein 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6YNQ3-1" }, "locus": { "chromosome": "13", "start_pos": 65086852, "end_pos": 65085803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007322.4", "url": "https://www.ensembl.org/id/ENSBTAT00000007322.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007322.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007322.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YNQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNQ3" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 213, "end_pos": 271, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YNV2-1", "uniprot_ac": "A0AAF6YNV2", "uniprot_id": "A0AAF6YNV2_BOVIN", "mass": { "chemical_mass": 32589.0, "monoisotopic_mass": 32589.0 }, "refseq": {}, "gene_names": [ { "name": "LAPTM5", "type": "recommended", "evidence": [ { "id": "A0AAF6YNV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ] } ], "protein_names": [ { "name": "Lysosomal protein transmembrane 5", "type": "synonym", "evidence": [ { "id": "A0AAF6YNV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAPTM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2", "locus": { "chromosome": "2", "start_pos": 122833480, "end_pos": 122806844, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005477", "url": "https://www.ensembl.org/id/ENSBTAG00000005477" } ] } } ], "crossref": [ { "id": "A0AAF6YNV2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YNV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12479", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12479", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12479:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12479:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03821", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03821", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRKHLTRLLVPSPSVPRRRGGSIMAPRAAAIRQTCCCFNVRIATTALAIYHVIMSVLLFIEHSVEVAHGKASCKFSKTGYLRIAELVSSFLLITMLFIISLSLLVGVVKNREKYLLPFLSLQIMDFLLCLLTLMGSYIELPAYLKFASRSSRRVSPSKVPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQDGMTHNQFIKIMIIFSIAFITVLILKVYMFKCVWRCYRLMKCTNSAEERSGSKMLQKVVLPSYEEAVSLPYKVPEGGPAPPPYSEV", "length": 288, "header": "tr|A0AAF6YNV2-1|A0AAF6YNV2_BOVIN Isoform 1 of Lysosomal protein transmembrane 5 OS=Bos taurus OX=9913 GN=LAPTM5 PE=3 SV=1 CANONICAL=A0AAF6YNV2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YNV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2/entry", "sequence": { "sequence": "MLRKHLTRLLVPSPSVPRRRGGSIMAPRAAAIRQTCCCFNVRIATTALAIYHVIMSVLLFIEHSVEVAHGKASCKFSKTGYLRIAELVSSFLLITMLFIISLSLLVGVVKNREKYLLPFLSLQIMDFLLCLLTLMGSYIELPAYLKFASRSSRRVSPSKVPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQDGMTHNQFIKIMIIFSIAFITVLILKVYMFKCVWRCYRLMKCTNSAEERSGSKMLQKVVLPSYEEAVSLPYKVPEGGPAPPPYSEV", "length": 288, "header": "tr|A0AAF6YNV2-1|A0AAF6YNV2_BOVIN Isoform 1 of Lysosomal protein transmembrane 5 OS=Bos taurus OX=9913 GN=LAPTM5 PE=3 SV=1 CANONICAL=A0AAF6YNV2-1" }, "locus": { "chromosome": "2", "start_pos": 122832172, "end_pos": 122806926, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007204.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007204.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007204.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007204.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 22, "go_terms": [ { "name": "positive regulation of receptor catabolic process", "id": "GO:2000646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000646", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of interleukin-2 production", "id": "GO:0032703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032703", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of lysosomal membrane permeability", "id": "GO:0097214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097214", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of type II interferon production", "id": "GO:0032689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032689", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "protein targeting to lysosome", "id": "GO:0006622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006622", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway", "id": "GO:0097193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "Golgi to lysosome transport", "id": "GO:0090160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090160", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of activated T cell proliferation", "id": "GO:0046007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046007", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor-mediated signaling pathway", "id": "GO:1903265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903265", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of macrophage cytokine production", "id": "GO:0060907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060907", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of B cell activation", "id": "GO:0050869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of ubiquitin-dependent protein catabolic process", "id": "GO:2000060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000060", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "positive regulation of interleukin-12 production", "id": "GO:0032735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of autophagic cell death", "id": "GO:1904093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904093", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "defense response to tumor cell", "id": "GO:0002357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002357", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "negative regulation of pre-B cell receptor expression", "id": "GO:0140646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140646", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "induction of programmed cell death", "id": "GO:0012502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012502", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YP31-1", "uniprot_ac": "A0AAF6YP31", "uniprot_id": "A0AAF6YP31_BOVIN", "mass": { "chemical_mass": 47585.0, "monoisotopic_mass": 47585.0 }, "refseq": { "ac": "XP_024834071", "name": "histone-binding protein RBBP4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834071" }, "gene_names": [ { "name": "RBBP4", "type": "recommended", "evidence": [ { "id": "A0AAF6YP31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ] }, { "name": "RBBP4", "type": "synonym", "evidence": [ { "id": "XP_024834071", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834071" } ] } ], "protein_names": [ { "name": "RB binding protein 4, chromatin remodeling factor", "type": "synonym", "evidence": [ { "id": "A0AAF6YP31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31/entry#names_and_taxonomy" } ] }, { "name": "histone-binding protein RBBP4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024834071", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834071" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31", "locus": { "chromosome": "2", "start_pos": 120969745, "end_pos": 120986405, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005904", "url": "https://www.ensembl.org/id/ENSBTAG00000005904" } ] } } ], "crossref": [ { "id": "A0AAF6YP31", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YP31", "database": "AlphaFoldDB", "categories": [] }, { "id": "767940", "url": "https://www.ncbi.nlm.nih.gov/gene/767940", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12265", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12265", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834071", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834071", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADKEAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS", "length": 424, "header": "tr|A0AAF6YP31-1|A0AAF6YP31_BOVIN Isoform 1 of RB binding protein 4, chromatin remodeling factor OS=Bos taurus OX=9913 GN=RBBP4 PE=3 SV=1 CANONICAL=A0AAF6YP31-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YP31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31/entry", "sequence": { "sequence": "MADKEAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS", "length": 424, "header": "tr|A0AAF6YP31-1|A0AAF6YP31_BOVIN Isoform 1 of RB binding protein 4, chromatin remodeling factor OS=Bos taurus OX=9913 GN=RBBP4 PE=3 SV=1 CANONICAL=A0AAF6YP31-1" }, "locus": { "chromosome": "2", "start_pos": 120986206, "end_pos": 120970654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007758.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007758.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007758.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007758.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "DNA replication-dependent chromatin assembly", "id": "GO:0006335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006335", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "ATP-dependent activity, acting on DNA", "id": "GO:0008094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008094", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "ESC/E(Z) complex", "id": "GO:0035098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035098", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "NURF complex", "id": "GO:0016589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016589", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "CAF-1 complex", "id": "GO:0033186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033186", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" }, { "name": "NuRD complex", "id": "GO:0016581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016581", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP31", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YP31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP31" }, { "id": "PF12265", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12265" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone-binding protein RBBP4-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 87, "start_aa": "Glu", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 328, "end_pos": 330 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YP69-1", "uniprot_ac": "A0AAF6YP69", "uniprot_id": "A0AAF6YP69_BOVIN", "mass": { "chemical_mass": 10940.0, "monoisotopic_mass": 10940.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM14C", "type": "recommended", "evidence": [ { "id": "A0AAF6YP69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69" } ] } ], "protein_names": [ { "name": "Transmembrane protein 14C", "type": "recommended", "evidence": [ { "id": "A0AAF6YP69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for normal heme biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP69", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69#function" }, { "database": "UniProtKB", "id": "ARBA00037428", "url": "https://www.uniprot.org/uniprotkb/ARBA00037428#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP69", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM14C", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69", "locus": { "chromosome": "23", "start_pos": 45406619, "end_pos": 45413410, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005808", "url": "https://www.ensembl.org/id/ENSBTAG00000005808" } ] } } ], "crossref": [ { "id": "A0AAF6YP69", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YP69", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12668", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12668", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12668:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12668:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YP69", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQHWLLPAGLLAMQKQVCVCVPPGSVPSLAAGLLFGGLAGLGSYQLSQDPKNIWLFLVTSGTLAGIMGMRFYNSRKFMPAGLIAGASLLMVVKLGISALSKPHQ", "length": 104, "header": "tr|A0AAF6YP69-1|A0AAF6YP69_BOVIN Isoform 1 of Transmembrane protein 14C OS=Bos taurus OX=9913 GN=TMEM14C PE=3 SV=1 CANONICAL=A0AAF6YP69-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YP69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69/entry", "sequence": { "sequence": "MQHWLLPAGLLAMQKQVCVCVPPGSVPSLAAGLLFGGLAGLGSYQLSQDPKNIWLFLVTSGTLAGIMGMRFYNSRKFMPAGLIAGASLLMVVKLGISALSKPHQ", "length": 104, "header": "tr|A0AAF6YP69-1|A0AAF6YP69_BOVIN Isoform 1 of Transmembrane protein 14C OS=Bos taurus OX=9913 GN=TMEM14C PE=3 SV=1 CANONICAL=A0AAF6YP69-1" }, "locus": { "chromosome": "23", "start_pos": 45411863, "end_pos": 45407095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007635.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007635.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007635.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007635.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP69", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP69", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "heme biosynthetic process", "id": "GO:0006783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP69", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YP72-1", "uniprot_ac": "A0AAF6YP72", "uniprot_id": "A0AAF6YP72_BOVIN", "mass": { "chemical_mass": 22471.0, "monoisotopic_mass": 22471.0 }, "refseq": {}, "gene_names": [ { "name": "FGF2", "type": "recommended", "evidence": [ { "id": "A0AAF6YP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ] } ], "protein_names": [ { "name": "Fibroblast growth factor", "type": "recommended", "evidence": [ { "id": "A0AAF6YP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72/entry#names_and_taxonomy" } ] }, { "name": "FGF", "type": "synonym", "evidence": [ { "id": "A0AAF6YP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FGF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72", "locus": { "chromosome": "17", "start_pos": 34801330, "end_pos": 34860763, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005691", "url": "https://www.ensembl.org/id/ENSBTAG00000005691" } ] } } ], "crossref": [ { "id": "A0AAF6YP72", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YP72", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11486", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11486", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00167", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00167", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VLPRSSPVPSSSPAVLSPAPAFQPPRSFFLFTVTPVGLVVSLRSALGGFGLTTRPPPAPSCGGGRRSSRLWSVPAAQQSQSPGPRAPGARALRAAPWAQTTCRVGGARRLSRVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS", "length": 208, "header": "tr|A0AAF6YP72-1|A0AAF6YP72_BOVIN Isoform 1 of Fibroblast growth factor OS=Bos taurus OX=9913 GN=FGF2 PE=3 SV=1 CANONICAL=A0AAF6YP72-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YP72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72/entry", "sequence": { "sequence": "VLPRSSPVPSSSPAVLSPAPAFQPPRSFFLFTVTPVGLVVSLRSALGGFGLTTRPPPAPSCGGGRRSSRLWSVPAAQQSQSPGPRAPGARALRAAPWAQTTCRVGGARRLSRVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS", "length": 208, "header": "tr|A0AAF6YP72-1|A0AAF6YP72_BOVIN Isoform 1 of Fibroblast growth factor OS=Bos taurus OX=9913 GN=FGF2 PE=3 SV=1 CANONICAL=A0AAF6YP72-1" }, "locus": { "chromosome": "17", "start_pos": 34860564, "end_pos": 34807356, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007477.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007477.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007477.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007477.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "negative regulation of fibroblast migration", "id": "GO:0010764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of sprouting angiogenesis", "id": "GO:1903672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903672", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of vascular endothelial cell proliferation", "id": "GO:1905564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905564", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "negative regulation of blood vessel endothelial cell migration", "id": "GO:0043537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043537", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "release of sequestered calcium ion into cytosol", "id": "GO:0051209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051209", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090050", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904707", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of blood vessel branching", "id": "GO:1905555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905555", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "negative regulation of wound healing", "id": "GO:0061045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of DNA biosynthetic process", "id": "GO:2000573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000573", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "wound healing", "id": "GO:0042060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "branching involved in ureteric bud morphogenesis", "id": "GO:0001658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001658", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of lens fiber cell differentiation", "id": "GO:1902748", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902748", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "hyaluronan catabolic process", "id": "GO:0030214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030214", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle cell proliferation", "id": "GO:0060045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "chondroblast differentiation", "id": "GO:0060591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060591", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "stem cell development", "id": "GO:0048864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048864", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of epithelial tube formation", "id": "GO:1905278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905278", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "growth factor dependent regulation of skeletal muscle satellite cell proliferation", "id": "GO:0014843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014843", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell chemotaxis to fibroblast growth factor", "id": "GO:2000546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000546", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "chemoattractant activity", "id": "GO:0042056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042056", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "receptor-receptor interaction", "id": "GO:0090722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090722", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "chemokine binding", "id": "GO:0019956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019956", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor binding", "id": "GO:0005104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005104", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP72", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YP81-1", "uniprot_ac": "A0AAF6YP81", "uniprot_id": "A0AAF6YP81_BOVIN", "mass": { "chemical_mass": 18605.0, "monoisotopic_mass": 18605.0 }, "refseq": {}, "gene_names": [ { "name": "LYZ2", "type": "recommended", "evidence": [ { "id": "A0AAF6YP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81" } ] } ], "protein_names": [ { "name": "lysozyme", "type": "recommended", "evidence": [ { "id": "A0AAF6YP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.17", "type": "synonym", "evidence": [ { "id": "A0AAF6YP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP81", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81#function" }, { "database": "UniProtKB", "id": "ARBA00002647", "url": "https://www.uniprot.org/uniprotkb/ARBA00002647#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP81", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81", "locus": { "chromosome": "5", "start_pos": 44365812, "end_pos": 44371561, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026088", "url": "https://www.ensembl.org/id/ENSBTAG00000026088" } ] } } ], "crossref": [ { "id": "A0AAF6YP81", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YP81", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16897", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16897", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11407", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11407", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11407:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11407:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YP81", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNSKSSSPWSVWTFDFSVNMKALVILGFLFLSVAVQGKVFERCELARTLKKLGLDGYKGVSLANWLCLTKWESSYNTKATNYNPSSESTDYGIFQINSKWWCNDGKTPNAVDGCHVSCSELMENDIAKAVACAKHIVSEQGITAWVAWKSHCRDHDVSSYVEGCTL", "length": 167, "header": "tr|A0AAF6YP81-1|A0AAF6YP81_BOVIN Isoform 1 of lysozyme OS=Bos taurus OX=9913 GN=LYZ2 PE=3 SV=1 CANONICAL=A0AAF6YP81-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YP81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81/entry", "sequence": { "sequence": "MLNSKSSSPWSVWTFDFSVNMKALVILGFLFLSVAVQGKVFERCELARTLKKLGLDGYKGVSLANWLCLTKWESSYNTKATNYNPSSESTDYGIFQINSKWWCNDGKTPNAVDGCHVSCSELMENDIAKAVACAKHIVSEQGITAWVAWKSHCRDHDVSSYVEGCTL", "length": 167, "header": "tr|A0AAF6YP81-1|A0AAF6YP81_BOVIN Isoform 1 of lysozyme OS=Bos taurus OX=9913 GN=LYZ2 PE=3 SV=1 CANONICAL=A0AAF6YP81-1" }, "locus": { "chromosome": "5", "start_pos": 44371513, "end_pos": 44366304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007924.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007924.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007924.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007924.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP81", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81" } ], "pmid": "" }, { "name": "killing of cells of another organism", "id": "GO:0031640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP81", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lysozyme activity", "id": "GO:0003796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003796", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YP81", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP81" }, { "id": "PS00128", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycosyl hydrolases family 22 (GH22)", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 133, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.17", "ec_name": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "3.2.1.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.17" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YPL2-1", "uniprot_ac": "A0AAF6YPL2", "uniprot_id": "A0AAF6YPL2_BOVIN", "mass": { "chemical_mass": 27435.0, "monoisotopic_mass": 27435.0 }, "refseq": {}, "gene_names": [ { "name": "POU2AF1", "type": "recommended", "evidence": [ { "id": "A0AAF6YPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ] } ], "protein_names": [ { "name": "POU class 2 homeobox associating factor 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POU2AF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2", "locus": { "chromosome": "15", "start_pos": 21635824, "end_pos": 21642141, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006282", "url": "https://www.ensembl.org/id/ENSBTAG00000006282" } ] } } ], "crossref": [ { "id": "A0AAF6YPL2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YPL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR015389", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015389", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15363", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15363", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15363:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15363:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09310", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09310", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YPL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SFWPPPATAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHASSGASVTPTAVVLPHQPLATYTTVGPSCLDMEVSASTVTEEGALCAGWLSQPAPAALQPLAPWTPYTEYVSHEAVSCPYSADMYVQPVCPSYTVVGPSSVLTYASQPLITNVTTRSAAAPTVGPPLEGPEHQAPLTYFPWPQPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLPDAEDPRRAIGSLTIDKLLLEEEDSDTYALNHTLSVEGF", "length": 257, "header": "tr|A0AAF6YPL2-1|A0AAF6YPL2_BOVIN Isoform 1 of POU class 2 homeobox associating factor 1 OS=Bos taurus OX=9913 GN=POU2AF1 PE=4 SV=1 CANONICAL=A0AAF6YPL2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YPL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2/entry", "sequence": { "sequence": "SFWPPPATAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHASSGASVTPTAVVLPHQPLATYTTVGPSCLDMEVSASTVTEEGALCAGWLSQPAPAALQPLAPWTPYTEYVSHEAVSCPYSADMYVQPVCPSYTVVGPSSVLTYASQPLITNVTTRSAAAPTVGPPLEGPEHQAPLTYFPWPQPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLPDAEDPRRAIGSLTIDKLLLEEEDSDTYALNHTLSVEGF", "length": 257, "header": "tr|A0AAF6YPL2-1|A0AAF6YPL2_BOVIN Isoform 1 of POU class 2 homeobox associating factor 1 OS=Bos taurus OX=9913 GN=POU2AF1 PE=4 SV=1 CANONICAL=A0AAF6YPL2-1" }, "locus": { "chromosome": "15", "start_pos": 21642141, "end_pos": 21637624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008246.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008246.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008246.4", "url": "https://www.ensembl.org/id/ENSBTAP00000008246.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 161, "start_aa": "Thr", "end_pos": 161, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr161", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" }, { "name": "POU domain binding", "id": "GO:0070974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070974", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" }, { "name": "germinal center B cell differentiation", "id": "GO:0002314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002314", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPL2" }, { "id": "PS52003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OCA", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 39, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 161 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 249, "end_pos": 251 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YPV1-1", "uniprot_ac": "A0AAF6YPV1", "uniprot_id": "A0AAF6YPV1_BOVIN", "mass": { "chemical_mass": 87762.0, "monoisotopic_mass": 87762.0 }, "refseq": {}, "gene_names": [ { "name": "LOXL2", "type": "recommended", "evidence": [ { "id": "A0AAF6YPV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ] } ], "protein_names": [ { "name": "Lysyl oxidase homolog", "type": "recommended", "evidence": [ { "id": "A0AAF6YPV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1/entry#names_and_taxonomy" } ] }, { "name": "1.4.3.13", "type": "synonym", "evidence": [ { "id": "A0AAF6YPV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1#function" }, { "database": "UniProtKB", "id": "RU367046", "url": "https://www.uniprot.org/uniprotkb/RU367046#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOXL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1", "locus": { "chromosome": "8", "start_pos": 70414276, "end_pos": 70527420, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006214", "url": "https://www.ensembl.org/id/ENSBTAG00000006214" } ] } } ], "crossref": [ { "id": "A0AAF6YPV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YPV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45817:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45817:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00530", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00530", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "24544", "url": "https://www.rhea-db.org/rhea/24544", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YPV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERRGSSCLCRCLALLALLPTLSLAQYESWRHYPEYFQEPAPEYHRPEVPSDVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFTIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNVYCTGSEATLAACSSNGWGVTDCKHTEDVGVVCSEKRIPGFKFDNSLINSIENMNIQVEDIRIRAILSAFRKRTPVTEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGEKTYNTKVYKMFAARKKQRYWPYSMDCTGTEAHISSCKLGPQVSLDPVKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGANVGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAITGSRLGQVHVHFLFPGIGPIHLNEIECTGNEKSIIDCKFNAESQGCNHEEDAAVRCNIPAMGFQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGENWGIVEAMVVCRQLGLGFASNAFQETWYWHGNINANKVVMSGVKCSGTELSLAHCRHDGEDVACPEGGVRYGAGVACSETAPDLVLNAEIVQQSTYLEDRPMFMLQCAMEENCLSASAAQTNPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNYEVAESDYTNNIMKCRTRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLINNQVSKR", "length": 782, "header": "tr|A0AAF6YPV1-1|A0AAF6YPV1_BOVIN Isoform 1 of Lysyl oxidase homolog OS=Bos taurus OX=9913 GN=LOXL2 PE=3 SV=1 CANONICAL=A0AAF6YPV1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YPV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1/entry", "sequence": { "sequence": "MERRGSSCLCRCLALLALLPTLSLAQYESWRHYPEYFQEPAPEYHRPEVPSDVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFTIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNVYCTGSEATLAACSSNGWGVTDCKHTEDVGVVCSEKRIPGFKFDNSLINSIENMNIQVEDIRIRAILSAFRKRTPVTEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGEKTYNTKVYKMFAARKKQRYWPYSMDCTGTEAHISSCKLGPQVSLDPVKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGANVGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAITGSRLGQVHVHFLFPGIGPIHLNEIECTGNEKSIIDCKFNAESQGCNHEEDAAVRCNIPAMGFQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGENWGIVEAMVVCRQLGLGFASNAFQETWYWHGNINANKVVMSGVKCSGTELSLAHCRHDGEDVACPEGGVRYGAGVACSETAPDLVLNAEIVQQSTYLEDRPMFMLQCAMEENCLSASAAQTNPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNYEVAESDYTNNIMKCRTRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLINNQVSKR", "length": 782, "header": "tr|A0AAF6YPV1-1|A0AAF6YPV1_BOVIN Isoform 1 of Lysyl oxidase homolog OS=Bos taurus OX=9913 GN=LOXL2 PE=3 SV=1 CANONICAL=A0AAF6YPV1-1" }, "locus": { "chromosome": "8", "start_pos": 70495255, "end_pos": 70415173, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008159.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008159.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008159.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008159.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "oligosaccharide binding", "id": "GO:0070492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070492", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "protein-lysine 6-oxidase activity", "id": "GO:0004720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004720", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "negative regulation of stem cell population maintenance", "id": "GO:1902455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902455", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "positive regulation of chondrocyte differentiation", "id": "GO:0032332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032332", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "response to copper ion", "id": "GO:0046688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046688", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "sprouting angiogenesis", "id": "GO:0002040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "epithelial to mesenchymal transition", "id": "GO:0001837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001837", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "endothelial cell proliferation", "id": "GO:0001935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001935", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "positive regulation of epithelial to mesenchymal transition", "id": "GO:0010718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010718", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "heterochromatin organization", "id": "GO:0070828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070828", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YPV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 652, "end_pos": 654, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24544", "name": "", "equation": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YPV1-1", "A6H737-1", "P33072-1", "E1BFC8-1", "Q95L39-1", "Q8MJ24-1", "G1K200-1" ], "evidence": [ { "id": "24544", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24544" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YPV1", "gene_name": "LOXL2", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "A0AAF6YPV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "A0AAF6YPV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" } ] } ] }, { "uniprot_ac": "A6H737", "gene_name": "LOXL2", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "A6H737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H737" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "A6H737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H737" } ] } ] }, { "uniprot_ac": "E1BFC8", "gene_name": "LOXL3", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "E1BFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC8" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "E1BFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC8" } ] } ] }, { "uniprot_ac": "G1K200", "gene_name": "LOXL4", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "G1K200", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K200" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "G1K200", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K200" } ] } ] }, { "uniprot_ac": "P33072", "gene_name": "LOX", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "P33072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33072" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "P33072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33072" } ] } ] }, { "uniprot_ac": "Q8MJ24", "gene_name": "LOXL4", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "Q8MJ24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ24" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "Q8MJ24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ24" } ] } ] }, { "uniprot_ac": "Q95L39", "gene_name": "LOXL1", "activity": [ { "ec_number": "1.4.3.13", "activity": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "Q95L39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L39" } ] }, { "ec_number": "1.4.3.13", "activity": "", "evidence": [ { "id": "Q95L39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L39" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YPV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPV1" }, { "id": "PS50287", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50287" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SRCR", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 159, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.4.3.13", "ec_name": "L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+).", "evidence": [ { "id": "1.4.3.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13" }, { "id": "1.4.3.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.4.3.13" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 288, "end_pos": 290 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 652, "end_pos": 654 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQ39-1", "uniprot_ac": "A0AAF6YQ39", "uniprot_id": "A0AAF6YQ39_BOVIN", "mass": { "chemical_mass": 71273.0, "monoisotopic_mass": 71273.0 }, "refseq": {}, "gene_names": [ { "name": "P4HA3", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ] } ], "protein_names": [ { "name": "Prolyl 4-hydroxylase subunit alpha-3", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39/entry#names_and_taxonomy" } ] }, { "name": "1.14.11.2", "type": "synonym", "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39/entry#names_and_taxonomy" } ] }, { "name": "Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3", "type": "synonym", "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39#function" }, { "database": "UniProtKB", "id": "ARBA00002035", "url": "https://www.uniprot.org/uniprotkb/ARBA00002035#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P4HA3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39", "locus": { "chromosome": "15", "start_pos": 53609604, "end_pos": 53682107, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006579", "url": "https://www.ensembl.org/id/ENSBTAG00000006579" } ] } } ], "crossref": [ { "id": "A0AAF6YQ39", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQ39", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006620", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006620", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10869:SF223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10869:SF223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08336", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08336", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23558", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23558", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "18945", "url": "https://www.rhea-db.org/rhea/18945", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQ39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSEGQEGRGWRARGGVSKESGAGPRAGRGRSGESRARRDARRGRARAPAMGPAARLAALLAVLAFRAGDPAEVAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYHKVLSLHEDSATPVSNPLLAFTLIKRLQSDWKNVVHSLEASENIRALKDGYERVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAVTDLYSPRRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFQAGNVLCALNLSREFLLYSPDNKRVARNVLKYEKLLAESPNQAVAETVMQRPNVPHLQTRDTYEGLCQTLGSQPTHYRIPSLYCSYETSSSPYLLLQPVRKEVIHLEPYVVLYHDFVSDAEAQTIRGLAEPWLQRSVVASGEKQLPVEYRISKSAWLKDTVDPVLVTLDHRIAALTGLDVQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMNSGNRVATFMIYLSSVEAGGATAFIYGNFSVPVVKNAALFWWNLHRSGEGDGDTLHAACPVLWPTSGYTSMDRNSADPAARDLKTKVLAERSWRSPLAFQRSQKSKTRVREEKGEQASGGGPCQHCLFLANGRQGSGL", "length": 642, "header": "tr|A0AAF6YQ39-1|A0AAF6YQ39_BOVIN Isoform 1 of Prolyl 4-hydroxylase subunit alpha-3 OS=Bos taurus OX=9913 GN=P4HA3 PE=3 SV=1 CANONICAL=A0AAF6YQ39-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQ39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39/entry", "sequence": { "sequence": "MQSEGQEGRGWRARGGVSKESGAGPRAGRGRSGESRARRDARRGRARAPAMGPAARLAALLAVLAFRAGDPAEVAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYHKVLSLHEDSATPVSNPLLAFTLIKRLQSDWKNVVHSLEASENIRALKDGYERVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAVTDLYSPRRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFQAGNVLCALNLSREFLLYSPDNKRVARNVLKYEKLLAESPNQAVAETVMQRPNVPHLQTRDTYEGLCQTLGSQPTHYRIPSLYCSYETSSSPYLLLQPVRKEVIHLEPYVVLYHDFVSDAEAQTIRGLAEPWLQRSVVASGEKQLPVEYRISKSAWLKDTVDPVLVTLDHRIAALTGLDVQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMNSGNRVATFMIYLSSVEAGGATAFIYGNFSVPVVKNAALFWWNLHRSGEGDGDTLHAACPVLWPTSGYTSMDRNSADPAARDLKTKVLAERSWRSPLAFQRSQKSKTRVREEKGEQASGGGPCQHCLFLANGRQGSGL", "length": 642, "header": "tr|A0AAF6YQ39-1|A0AAF6YQ39_BOVIN Isoform 1 of Prolyl 4-hydroxylase subunit alpha-3 OS=Bos taurus OX=9913 GN=P4HA3 PE=3 SV=1 CANONICAL=A0AAF6YQ39-1" }, "locus": { "chromosome": "15", "start_pos": 53681908, "end_pos": 53641230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008644.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008644.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008644.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008644.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ], "pmid": "" }, { "name": "L-ascorbic acid binding", "id": "GO:0031418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031418", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ], "pmid": "" }, { "name": "procollagen-proline 4-dioxygenase activity", "id": "GO:0004656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004656", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ39", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18945", "name": "", "equation": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1RMU3-1", "Q75UG4-1", "A0AAF6YQ39-1" ], "evidence": [ { "id": "18945", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18945" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YQ39", "gene_name": "P4HA3", "activity": [ { "ec_number": "1.14.11.2", "activity": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2.", "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ] }, { "ec_number": "1.14.11.2", "activity": "", "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" } ] } ] }, { "uniprot_ac": "Q1RMU3", "gene_name": "P4HA1", "activity": [ { "ec_number": "1.14.11.2", "activity": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2.", "evidence": [ { "id": "Q1RMU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMU3" } ] }, { "ec_number": "1.14.11.2", "activity": "", "evidence": [ { "id": "Q1RMU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMU3" } ] } ] }, { "uniprot_ac": "Q75UG4", "gene_name": "P4HA3", "activity": [ { "ec_number": "1.14.11.2", "activity": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2.", "evidence": [ { "id": "Q75UG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75UG4" } ] }, { "ec_number": "1.14.11.2", "activity": "", "evidence": [ { "id": "Q75UG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75UG4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YQ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ39" }, { "id": "PS51471", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51471" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fe2OG dioxygenase", "eco_id": "ECO_0000259", "start_pos": 472, "end_pos": 588, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.11.2", "ec_name": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2.", "evidence": [ { "id": "1.14.11.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.2" }, { "id": "1.14.11.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.11.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 532, "end_pos": 534 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQ55-1", "uniprot_ac": "A0AAF6YQ55", "uniprot_id": "A0AAF6YQ55_BOVIN", "mass": { "chemical_mass": 16644.0, "monoisotopic_mass": 16644.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Alpha-hemoglobin-stabilizing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55/entry#names_and_taxonomy" } ] }, { "name": "Erythroid-associated factor", "type": "synonym", "evidence": [ { "id": "A0AAF6YQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55", "locus": {} } ], "crossref": [ { "id": "A0AAF6YQ55", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQ55", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR015317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15914", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15914", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15914:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15914:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09236", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQ55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKDVTENTYLFNVGYFVGGRSKNDPFFHLAQRESQSLKSVAETYTAPLDLKMALIQTNKDLISKGIKEFNILLNQQVFSDPAISEEAMVTVVNDWVSFYINYYKKQLSGEQDEQDKALQEFRQELNTLSASFLDKYRNFLKSS", "length": 144, "header": "tr|A0AAF6YQ55-1|A0AAF6YQ55_BOVIN Isoform 1 of Alpha-hemoglobin-stabilizing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YQ55-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQ55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55/entry", "sequence": { "sequence": "MEKDVTENTYLFNVGYFVGGRSKNDPFFHLAQRESQSLKSVAETYTAPLDLKMALIQTNKDLISKGIKEFNILLNQQVFSDPAISEEAMVTVVNDWVSFYINYYKKQLSGEQDEQDKALQEFRQELNTLSASFLDKYRNFLKSS", "length": 144, "header": "tr|A0AAF6YQ55-1|A0AAF6YQ55_BOVIN Isoform 1 of Alpha-hemoglobin-stabilizing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YQ55-1" }, "locus": { "chromosome": "25", "start_pos": 27543968, "end_pos": 27542287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008467.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008467.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008467.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008467.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hemoglobin binding", "id": "GO:0030492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030492", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQ79-1", "uniprot_ac": "A0AAF6YQ79", "uniprot_id": "A0AAF6YQ79_BOVIN", "mass": { "chemical_mass": 38808.0, "monoisotopic_mass": 38808.0 }, "refseq": { "ac": "XP_005214715", "name": "sperm flagellar protein 1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214715" }, "gene_names": [ { "name": "SPEF1", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ] }, { "name": "C20orf28", "type": "synonym", "evidence": [ { "id": "XP_005214715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214715" } ] }, { "name": "SPEF1", "type": "synonym", "evidence": [ { "id": "XP_005214715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214715" } ] } ], "protein_names": [ { "name": "Sperm flagellar protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79/entry#names_and_taxonomy" } ] }, { "name": "sperm flagellar protein 1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005214715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214715" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPEF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79", "locus": { "chromosome": "13", "start_pos": 51426021, "end_pos": 51422410, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006578", "url": "https://www.ensembl.org/id/ENSBTAG00000006578" } ] } } ], "crossref": [ { "id": "A0AAF6YQ79", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQ79", "database": "AlphaFoldDB", "categories": [] }, { "id": "512410", "url": "https://www.ncbi.nlm.nih.gov/gene/512410", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12509", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12509", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12509:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12509:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214715", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214715", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQ79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSVDEEALHQLYLWVDNIPLSRPKRNLSRDFSDGVLVAEVIKFYFPKMVEMHNYVPANSLQQKLSNWSHLNRKVLNKLNFSVPEDVMRKIAQCAPGVVELVLIPLRQRLEERQRRRKQGIGSLQELAPQDGTDYMDVGLSQKARGEGVPDPQGRGQLREGRLPVPRPPGDSQALQSDPSFILQIAEKEQELLASQETVQVLQMKVRRLEHLLQLKNVRIEDLSRRLQQAERKQRRMDRFPEPRSHMQRPGVHPKSVLDTRDSALVLPVLGLSGWSPSLVHTLRTGSPPSSGDSSVSIQASSLYHGSKGRLSETAEGLPCPSWALTWDPAEDWRTQQLKRKG", "length": 343, "header": "tr|A0AAF6YQ79-1|A0AAF6YQ79_BOVIN Isoform 1 of Sperm flagellar protein 1 OS=Bos taurus OX=9913 GN=SPEF1 PE=4 SV=1 CANONICAL=A0AAF6YQ79-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQ79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79/entry", "sequence": { "sequence": "MAGSVDEEALHQLYLWVDNIPLSRPKRNLSRDFSDGVLVAEVIKFYFPKMVEMHNYVPANSLQQKLSNWSHLNRKVLNKLNFSVPEDVMRKIAQCAPGVVELVLIPLRQRLEERQRRRKQGIGSLQELAPQDGTDYMDVGLSQKARGEGVPDPQGRGQLREGRLPVPRPPGDSQALQSDPSFILQIAEKEQELLASQETVQVLQMKVRRLEHLLQLKNVRIEDLSRRLQQAERKQRRMDRFPEPRSHMQRPGVHPKSVLDTRDSALVLPVLGLSGWSPSLVHTLRTGSPPSSGDSSVSIQASSLYHGSKGRLSETAEGLPCPSWALTWDPAEDWRTQQLKRKG", "length": 343, "header": "tr|A0AAF6YQ79-1|A0AAF6YQ79_BOVIN Isoform 1 of Sperm flagellar protein 1 OS=Bos taurus OX=9913 GN=SPEF1 PE=4 SV=1 CANONICAL=A0AAF6YQ79-1" }, "locus": { "chromosome": "13", "start_pos": 51425861, "end_pos": 51422578, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008640.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008640.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008640.4", "url": "https://www.ensembl.org/id/ENSBTAP00000008640.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "axonemal central apparatus assembly", "id": "GO:1904158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904158", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "filopodium assembly", "id": "GO:0046847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046847", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "lamellipodium assembly", "id": "GO:0030032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030032", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "negative regulation of microtubule depolymerization", "id": "GO:0007026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "axonemal central apparatus", "id": "GO:1990716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990716", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "9+2 motile cilium", "id": "GO:0097729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ79", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YQ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ79" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 112, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 28, "end_pos": 30 }, { "start_pos": 68, "end_pos": 70 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQ96-1", "uniprot_ac": "A0AAF6YQ96", "uniprot_id": "A0AAF6YQ96_BOVIN", "mass": { "chemical_mass": 18067.0, "monoisotopic_mass": 18067.0 }, "refseq": {}, "gene_names": [ { "name": "GABARAPL2", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ] } ], "protein_names": [ { "name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "type": "recommended", "evidence": [ { "id": "A0AAF6YQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96/entry#names_and_taxonomy" } ] }, { "name": "GABA(A) receptor-associated protein-like 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96/entry#names_and_taxonomy" } ] }, { "name": "Golgi-associated ATPase enhancer of 16 kDa", "type": "synonym", "evidence": [ { "id": "A0AAF6YQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96#function" }, { "database": "UniProtKB", "id": "ARBA00056137", "url": "https://www.uniprot.org/uniprotkb/ARBA00056137#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GABARAPL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96", "locus": { "chromosome": "18", "start_pos": 2878363, "end_pos": 2863192, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006550", "url": "https://www.ensembl.org/id/ENSBTAG00000006550" } ] } } ], "crossref": [ { "id": "A0AAF6YQ96", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQ96", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02991", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02991", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQ96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P287", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P287", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P287-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P287-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVNWKKTAGSRRRRRCCCGWCAELRGSESRLRPFFAAAMKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF", "length": 155, "header": "tr|A0AAF6YQ96-1|A0AAF6YQ96_BOVIN Isoform 1 of Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Bos taurus OX=9913 GN=GABARAPL2 PE=3 SV=1 CANONICAL=A0AAF6YQ96-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQ96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96/entry", "sequence": { "sequence": "MVNWKKTAGSRRRRRCCCGWCAELRGSESRLRPFFAAAMKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF", "length": 155, "header": "tr|A0AAF6YQ96-1|A0AAF6YQ96_BOVIN Isoform 1 of Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Bos taurus OX=9913 GN=GABARAPL2 PE=3 SV=1 CANONICAL=A0AAF6YQ96-1" }, "locus": { "chromosome": "18", "start_pos": 2877849, "end_pos": 2865274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008607.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008607.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008607.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008607.5" } ] } }, { "isoform_ac": "A0ABI0P287-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P287/entry", "sequence": { "sequence": "MKWMFKEDHSLEHRCVESAKIRAKYPDRVPPNYGTALREGKR", "length": 42, "header": "tr|A0ABI0P287-1|A0ABI0P287_BOVIN Computationally mapped isoform of GABA type A receptor associated protein like 2 OS=Bos taurus OX=9913 GN=GABARAPL2 PE=4 SV=1 CANONICAL=A0AAF6YQ96-1" }, "locus": { "chromosome": "18", "start_pos": 2877797, "end_pos": 2868372, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104509.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104509.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "protein localization to endoplasmic reticulum", "id": "GO:0070972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070972", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "negative regulation of proteasomal protein catabolic process", "id": "GO:1901799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901799", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" }, { "name": "phosphatidylethanolamine binding", "id": "GO:0008429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQ96" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQA7-1", "uniprot_ac": "A0AAF6YQA7", "uniprot_id": "A0AAF6YQA7_BOVIN", "mass": { "chemical_mass": 26535.0, "monoisotopic_mass": 26535.0 }, "refseq": {}, "gene_names": [ { "name": "PSMA1", "type": "recommended", "evidence": [ { "id": "A0AAF6YQA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ] } ], "protein_names": [ { "name": "Proteasome subunit alpha type-1", "type": "recommended", "evidence": [ { "id": "A0AAF6YQA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7#function" }, { "database": "UniProtKB", "id": "ARBA00003876", "url": "https://www.uniprot.org/uniprotkb/ARBA00003876#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7", "locus": { "chromosome": "15", "start_pos": 38226753, "end_pos": 38213783, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006564", "url": "https://www.ensembl.org/id/ENSBTAG00000006564" } ] } } ], "crossref": [ { "id": "A0AAF6YQA7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03749", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03749", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPTQPADEPAEKADEPMEH", "length": 238, "header": "tr|A0AAF6YQA7-1|A0AAF6YQA7_BOVIN Isoform 1 of Proteasome subunit alpha type-1 OS=Bos taurus OX=9913 GN=PSMA1 PE=3 SV=2 CANONICAL=A0AAF6YQA7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7/entry", "sequence": { "sequence": "MEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPTQPADEPAEKADEPMEH", "length": 238, "header": "tr|A0AAF6YQA7-1|A0AAF6YQA7_BOVIN Isoform 1 of Proteasome subunit alpha type-1 OS=Bos taurus OX=9913 GN=PSMA1 PE=3 SV=2 CANONICAL=A0AAF6YQA7-1" }, "locus": { "chromosome": "15", "start_pos": 38226437, "end_pos": 38215626, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008621.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008621.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008621.4", "url": "https://www.ensembl.org/id/ENSBTAP00000008621.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" }, { "name": "proteasome core complex, alpha-subunit complex", "id": "GO:0019773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019773", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response to antigenic stimulus", "id": "GO:0002862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002862", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipopolysaccharide binding", "id": "GO:0001530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001530", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQA7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQE1-1", "uniprot_ac": "A0AAF6YQE1", "uniprot_id": "A0AAF6YQE1_BOVIN", "mass": { "chemical_mass": 40290.0, "monoisotopic_mass": 40290.0 }, "refseq": {}, "gene_names": [ { "name": "ASRGL1", "type": "recommended", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] } ], "protein_names": [ { "name": "Isoaspartyl peptidase/L-asparaginase", "type": "recommended", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.5", "type": "synonym", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.1", "type": "synonym", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] }, { "name": "Asparaginase-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] }, { "name": "Beta-aspartyl-peptidase", "type": "synonym", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] }, { "name": "Isoaspartyl dipeptidase", "type": "synonym", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] }, { "name": "L-asparagine amidohydrolase", "type": "synonym", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASRGL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1", "locus": { "chromosome": "29", "start_pos": 40775186, "end_pos": 40755178, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006910", "url": "https://www.ensembl.org/id/ENSBTAG00000006910" } ] } } ], "crossref": [ { "id": "A0AAF6YQE1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04702", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04702", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10188:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10188:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "21016", "url": "https://www.rhea-db.org/rhea/21016", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGSELQMETQLEVKGKNDMGRPSVGAEPLPAERLPAEQFPEQLCGETRLCRFRGRQGGSPEPESPASASCGVLGSIAMNPVVVVHGGGASNISKDRKERVRQGILRAATVGYNILKQGGSAVDAVEGAVTVLEDDPDFNAGCGSVLNENGEVEMDASIMNGKDLSAGAVSAVRCIANPIKLARLVMDKTPHCFLTDQGAARFAAANGIPTIPGQQLVTERSRKRLEKEKLEKDAQKPDCQKNLGTVGAVALDCQGNLAYATSTGGIVNKMPGRVGDTPCVGSGGYADNDIGAVSTTGHGESILKVNLARLALFHVEQGKSLEEAANASLGHMKSKVKGVGGIIMVNKAGEWAVKWTSTSMPWAAAKDGKLHSGIDFGDTSIIDLS", "length": 386, "header": "tr|A0AAF6YQE1-1|A0AAF6YQE1_BOVIN Isoform 1 of Isoaspartyl peptidase/L-asparaginase OS=Bos taurus OX=9913 GN=ASRGL1 PE=3 SV=1 CANONICAL=A0AAF6YQE1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1/entry", "sequence": { "sequence": "MVGSELQMETQLEVKGKNDMGRPSVGAEPLPAERLPAEQFPEQLCGETRLCRFRGRQGGSPEPESPASASCGVLGSIAMNPVVVVHGGGASNISKDRKERVRQGILRAATVGYNILKQGGSAVDAVEGAVTVLEDDPDFNAGCGSVLNENGEVEMDASIMNGKDLSAGAVSAVRCIANPIKLARLVMDKTPHCFLTDQGAARFAAANGIPTIPGQQLVTERSRKRLEKEKLEKDAQKPDCQKNLGTVGAVALDCQGNLAYATSTGGIVNKMPGRVGDTPCVGSGGYADNDIGAVSTTGHGESILKVNLARLALFHVEQGKSLEEAANASLGHMKSKVKGVGGIIMVNKAGEWAVKWTSTSMPWAAAKDGKLHSGIDFGDTSIIDLS", "length": 386, "header": "tr|A0AAF6YQE1-1|A0AAF6YQE1_BOVIN Isoform 1 of Isoaspartyl peptidase/L-asparaginase OS=Bos taurus OX=9913 GN=ASRGL1 PE=3 SV=1 CANONICAL=A0AAF6YQE1-1" }, "locus": { "chromosome": "29", "start_pos": 40775092, "end_pos": 40755274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009073.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009073.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009073.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009073.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "pmid": "" }, { "name": "L-asparagine catabolic process via L-aspartate", "id": "GO:0033345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033345", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "asparaginase activity", "id": "GO:0004067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004067", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "pmid": "" }, { "name": "beta-aspartyl-peptidase activity", "id": "GO:0008798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008798", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21016", "name": "", "equation": "L-asparagine + H2O = L-aspartate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YQE1-1", "Q32LE5-1", "F1MGH2-1" ], "evidence": [ { "id": "21016", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21016" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YQE1", "gene_name": "ASRGL1", "activity": [ { "ec_number": "3.4.19.5", "activity": "Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] }, { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] }, { "ec_number": "3.4.19.5", "activity": "", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] } ] }, { "uniprot_ac": "F1MGH2", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] } ] }, { "uniprot_ac": "Q32LE5", "gene_name": "ASRGL1", "activity": [ { "ec_number": "3.4.19.5", "activity": "Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.", "evidence": [ { "id": "Q32LE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE5" } ] }, { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "Q32LE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE5" } ] }, { "ec_number": "3.4.19.5", "activity": "", "evidence": [ { "id": "Q32LE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE5" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "Q32LE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.5", "ec_name": "Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.", "evidence": [ { "id": "3.4.19.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.5" } ] }, { "ec_number": "3.5.1.1", "ec_name": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "3.5.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1" }, { "id": "3.5.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.1" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 327, "end_pos": 329 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQQ5-1", "uniprot_ac": "A0AAF6YQQ5", "uniprot_id": "A0AAF6YQQ5_BOVIN", "mass": { "chemical_mass": 9495.0, "monoisotopic_mass": 9495.0 }, "refseq": {}, "gene_names": [ { "name": "HCST", "type": "recommended", "evidence": [ { "id": "A0AAF6YQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ] } ], "protein_names": [ { "name": "Hematopoietic cell signal transducer", "type": "recommended", "evidence": [ { "id": "A0AAF6YQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5/entry#names_and_taxonomy" } ] }, { "name": "DNAX-activation protein 10", "type": "synonym", "evidence": [ { "id": "A0AAF6YQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5/entry#names_and_taxonomy" } ] }, { "name": "Membrane protein DAP10", "type": "synonym", "evidence": [ { "id": "A0AAF6YQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HCST", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5", "locus": { "chromosome": "18", "start_pos": 46591222, "end_pos": 46589766, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007336", "url": "https://www.ensembl.org/id/ENSBTAG00000007336" } ] } } ], "crossref": [ { "id": "A0AAF6YQQ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQQ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR009861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21409", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21409", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21409:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21409:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPPGNILFLLLLPVATAQMTPGEKSTPTPLHGITSGSCSGCGPLSLPLLAGLVAADAVVSLLIVVVVFVCARLRSRPTQDDKIYINMPGRG", "length": 92, "header": "tr|A0AAF6YQQ5-1|A0AAF6YQQ5_BOVIN Isoform 1 of Hematopoietic cell signal transducer OS=Bos taurus OX=9913 GN=HCST PE=3 SV=1 CANONICAL=A0AAF6YQQ5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5/entry", "sequence": { "sequence": "MVPPGNILFLLLLPVATAQMTPGEKSTPTPLHGITSGSCSGCGPLSLPLLAGLVAADAVVSLLIVVVVFVCARLRSRPTQDDKIYINMPGRG", "length": 92, "header": "tr|A0AAF6YQQ5-1|A0AAF6YQQ5_BOVIN Isoform 1 of Hematopoietic cell signal transducer OS=Bos taurus OX=9913 GN=HCST PE=3 SV=1 CANONICAL=A0AAF6YQQ5-1" }, "locus": { "chromosome": "18", "start_pos": 46591098, "end_pos": 46589831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009651.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009651.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009651.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009651.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase binding", "id": "GO:0043548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043548", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" }, { "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQQ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQS8-1", "uniprot_ac": "A0AAF6YQS8", "uniprot_id": "A0AAF6YQS8_BOVIN", "mass": { "chemical_mass": 28489.0, "monoisotopic_mass": 28489.0 }, "refseq": {}, "gene_names": [ { "name": "DBP", "type": "recommended", "evidence": [ { "id": "A0AAF6YQS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ] } ], "protein_names": [ { "name": "D-box binding PAR bZIP transcription factor", "type": "synonym", "evidence": [ { "id": "A0AAF6YQS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DBP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8", "locus": { "chromosome": "18", "start_pos": 55272313, "end_pos": 55278976, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006754", "url": "https://www.ensembl.org/id/ENSBTAG00000006754" } ] } } ], "crossref": [ { "id": "A0AAF6YQS8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14695", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14695", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11988", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11988", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11988:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11988:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQLGRWWAAGPRGDARGLRPARVCWRRYCGSGHCRSATWSTWTWTLSCWNTGFLPARRPRAARRQRPHRCALPHLPRGPAPAARPPLALRPGTPPPGLPSGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL", "length": 251, "header": "tr|A0AAF6YQS8-1|A0AAF6YQS8_BOVIN Isoform 1 of D-box binding PAR bZIP transcription factor OS=Bos taurus OX=9913 GN=DBP PE=3 SV=1 CANONICAL=A0AAF6YQS8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8/entry", "sequence": { "sequence": "MLQLGRWWAAGPRGDARGLRPARVCWRRYCGSGHCRSATWSTWTWTLSCWNTGFLPARRPRAARRQRPHRCALPHLPRGPAPAARPPLALRPGTPPPGLPSGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL", "length": 251, "header": "tr|A0AAF6YQS8-1|A0AAF6YQS8_BOVIN Isoform 1 of D-box binding PAR bZIP transcription factor OS=Bos taurus OX=9913 GN=DBP PE=3 SV=1 CANONICAL=A0AAF6YQS8-1" }, "locus": { "chromosome": "18", "start_pos": 55277412, "end_pos": 55272578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008883.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008883.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008883.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008883.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YQS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQS8" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 181, "end_pos": 244, "start_aa": "Asp", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQW2-1", "uniprot_ac": "A0AAF6YQW2", "uniprot_id": "A0AAF6YQW2_BOVIN", "mass": { "chemical_mass": 20447.0, "monoisotopic_mass": 20447.0 }, "refseq": { "ac": "XP_024843514", "name": "fetal and adult testis-expressed transcript protein homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843514" }, "gene_names": [ { "name": "FATE1", "type": "recommended", "evidence": [ { "id": "A0AAF6YQW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2" } ] }, { "name": "FATE1", "type": "synonym", "evidence": [ { "id": "XP_024843514", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843514" } ] }, { "name": "FATE", "type": "synonym", "evidence": [ { "id": "XP_024843514", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843514" } ] } ], "protein_names": [ { "name": "Fetal and adult testis expressed 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YQW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2/entry#names_and_taxonomy" } ] }, { "name": "fetal and adult testis-expressed transcript protein homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024843514", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843514" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FATE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2", "locus": { "chromosome": "X", "start_pos": 34203510, "end_pos": 34197027, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006820", "url": "https://www.ensembl.org/id/ENSBTAG00000006820" } ] } } ], "crossref": [ { "id": "A0AAF6YQW2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "281153", "url": "https://www.ncbi.nlm.nih.gov/gene/281153", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21128", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21128", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21128:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21128:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05644", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05644", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024843514", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843514", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YQW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGGAVPNLKEKMQVPKDEDLLLGSFRDNQECSVAAEMKEHMSRLLGASQRRQRVDPKAVGSAVVWNTAANQSKKMGPQLRGVGVVGEQGDGGAQPQENPGGSQGMRSQFERSRELNTLAEIGLEELNELEMEIMRRQLFMITERLRYLEDQSATWHQREVLLFTMLLSSCITNLWLWMRQ", "length": 181, "header": "tr|A0AAF6YQW2-1|A0AAF6YQW2_BOVIN Isoform 1 of Fetal and adult testis expressed 1 OS=Bos taurus OX=9913 GN=FATE1 PE=4 SV=1 CANONICAL=A0AAF6YQW2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2/entry", "sequence": { "sequence": "MAGGAVPNLKEKMQVPKDEDLLLGSFRDNQECSVAAEMKEHMSRLLGASQRRQRVDPKAVGSAVVWNTAANQSKKMGPQLRGVGVVGEQGDGGAQPQENPGGSQGMRSQFERSRELNTLAEIGLEELNELEMEIMRRQLFMITERLRYLEDQSATWHQREVLLFTMLLSSCITNLWLWMRQ", "length": 181, "header": "tr|A0AAF6YQW2-1|A0AAF6YQW2_BOVIN Isoform 1 of Fetal and adult testis expressed 1 OS=Bos taurus OX=9913 GN=FATE1 PE=4 SV=1 CANONICAL=A0AAF6YQW2-1" }, "locus": { "chromosome": "X", "start_pos": 34203053, "end_pos": 34197086, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008963.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008963.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008963.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008963.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YQW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW2" }, { "id": "PF05644", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05644" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mff-like", "eco_id": "ECO_0000259", "start_pos": 103, "end_pos": 180, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YQW5-1", "uniprot_ac": "A0AAF6YQW5", "uniprot_id": "A0AAF6YQW5_BOVIN", "mass": { "chemical_mass": 16296.0, "monoisotopic_mass": 16296.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Large ribosomal subunit protein uL11", "type": "recommended", "evidence": [ { "id": "A0AAF6YQW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L12", "type": "synonym", "evidence": [ { "id": "A0AAF6YQW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5#function" }, { "database": "UniProtKB", "id": "ARBA00045484", "url": "https://www.uniprot.org/uniprotkb/ARBA00045484#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5", "locus": {} } ], "crossref": [ { "id": "A0AAF6YQW5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YQW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00349", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00349", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11661:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00298", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00298", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YQW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS", "length": 152, "header": "tr|A0AAF6YQW5-1|A0AAF6YQW5_BOVIN Isoform 1 of Large ribosomal subunit protein uL11 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YQW5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YQW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5/entry", "sequence": { "sequence": "MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS", "length": 152, "header": "tr|A0AAF6YQW5-1|A0AAF6YQW5_BOVIN Isoform 1 of Large ribosomal subunit protein uL11 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YQW5-1" }, "locus": { "chromosome": "10", "start_pos": 83129795, "end_pos": 83129301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009155.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009155.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009155.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009155.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YQW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YQW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQW5" }, { "id": "PF00298", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00298" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL11 C-terminal", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 130, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YR53-1", "uniprot_ac": "A0AAF6YR53", "uniprot_id": "A0AAF6YR53_BOVIN", "mass": { "chemical_mass": 29848.0, "monoisotopic_mass": 29848.0 }, "refseq": {}, "gene_names": [ { "name": "FTL", "type": "recommended", "evidence": [ { "id": "A0AAF6YR53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ] } ], "protein_names": [ { "name": "Ferritin", "type": "recommended", "evidence": [ { "id": "A0AAF6YR53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53#function" }, { "database": "UniProtKB", "id": "ARBA00045578", "url": "https://www.uniprot.org/uniprotkb/ARBA00045578#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FTL", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53", "locus": { "chromosome": "23", "start_pos": 34453592, "end_pos": 34454574, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038430", "url": "https://www.ensembl.org/id/ENSBTAG00000038430" } ] } } ], "crossref": [ { "id": "A0AAF6YR53", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YR53", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00904", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00904", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11431:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11431:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTGRRSPGKPSRELKRQLLKCARRPRGSVSCFNSAWTEQTQGRPLLQPPTTLQPFFQSQPSESATQLSAITGTSHHFLTPYYYRPIMSSQIRQNYSTEVEAAVNRLVNMQLRASYTYLSLGFYFDRDDVALEGVGHFFRELAKEKREGAERLLKLQNQRGGRALFLDVQKPSQDEWGKTQDAMEAALLVEKNLNQALLDLHGLASARGDPHICDFLENHFLDEEVKLIKKMGDHLTNLRRLAGPQAGLGEYLFERLTLKHD", "length": 262, "header": "tr|A0AAF6YR53-1|A0AAF6YR53_BOVIN Isoform 1 of Ferritin OS=Bos taurus OX=9913 GN=FTL PE=3 SV=1 CANONICAL=A0AAF6YR53-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YR53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53/entry", "sequence": { "sequence": "MDTGRRSPGKPSRELKRQLLKCARRPRGSVSCFNSAWTEQTQGRPLLQPPTTLQPFFQSQPSESATQLSAITGTSHHFLTPYYYRPIMSSQIRQNYSTEVEAAVNRLVNMQLRASYTYLSLGFYFDRDDVALEGVGHFFRELAKEKREGAERLLKLQNQRGGRALFLDVQKPSQDEWGKTQDAMEAALLVEKNLNQALLDLHGLASARGDPHICDFLENHFLDEEVKLIKKMGDHLTNLRRLAGPQAGLGEYLFERLTLKHD", "length": 262, "header": "tr|A0AAF6YR53-1|A0AAF6YR53_BOVIN Isoform 1 of Ferritin OS=Bos taurus OX=9913 GN=FTL PE=3 SV=1 CANONICAL=A0AAF6YR53-1" }, "locus": { "chromosome": "18", "start_pos": 55540210, "end_pos": 55536835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009965.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009965.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009965.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009965.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular iron ion homeostasis", "id": "GO:0006879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ], "pmid": "" }, { "name": "iron ion transport", "id": "GO:0006826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006826", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ], "pmid": "" }, { "name": "autolysosome", "id": "GO:0044754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044754", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ferric iron binding", "id": "GO:0008199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008199", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YR53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" }, { "id": "PS50905", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50905" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ferritin-like diiron", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 243, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "A0AAF6YR53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR53" }, { "id": "PIRSR601519-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601519-1" } ], "binding_site_uniprot": 191, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:24875", "ligand": "Fe cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 191, "end_pos": 191, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YSZ8-1", "uniprot_ac": "A0AAF6YSZ8", "uniprot_id": "A0AAF6YSZ8_BOVIN", "mass": { "chemical_mass": 17628.0, "monoisotopic_mass": 17628.0 }, "refseq": { "ac": "NP_777250", "name": "cathelicidin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250" }, "gene_names": [ { "name": "CATHL1", "type": "recommended", "evidence": [ { "id": "A0AAF6YSZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8" } ] }, { "name": "CATHL1", "type": "synonym", "evidence": [ { "id": "NP_777250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250" } ] } ], "protein_names": [ { "name": "Cathelicidin 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YSZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8/entry#names_and_taxonomy" } ] }, { "name": "bac1", "type": "synonym", "evidence": [ { "id": "NP_777250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250" } ] }, { "name": "bactenecin-1", "type": "synonym", "evidence": [ { "id": "NP_777250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250" } ] }, { "name": "cathelicidin-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_777250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250" } ] }, { "name": "cyclic dodecapeptide", "type": "synonym", "evidence": [ { "id": "NP_777250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YSZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CATHL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8", "locus": { "chromosome": "22", "start_pos": 51599668, "end_pos": 51601097, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003022", "url": "https://www.ensembl.org/id/ENSBTAG00000003022" } ] } } ], "crossref": [ { "id": "A0AAF6YSZ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YSZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "282164", "url": "https://www.ncbi.nlm.nih.gov/gene/282164", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282164", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282164", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10206:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10206:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00666", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00666", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777250", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YSZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YSZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METPRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQLNEQSSEPNIYRLLELDQPPQDDEDPDSPKRVSFRVKETVCSRTTQQPPEQCDFKENGLLKRCEGTVTLDQVRGNFDITCNNHRSIRITKQPWAPPQAARLCRIVVIRVCR", "length": 155, "header": "tr|A0AAF6YSZ8-1|A0AAF6YSZ8_BOVIN Isoform 1 of Cathelicidin 1 OS=Bos taurus OX=9913 GN=CATHL1 PE=3 SV=1 CANONICAL=A0AAF6YSZ8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YSZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8/entry", "sequence": { "sequence": "METPRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQLNEQSSEPNIYRLLELDQPPQDDEDPDSPKRVSFRVKETVCSRTTQQPPEQCDFKENGLLKRCEGTVTLDQVRGNFDITCNNHRSIRITKQPWAPPQAARLCRIVVIRVCR", "length": 155, "header": "tr|A0AAF6YSZ8-1|A0AAF6YSZ8_BOVIN Isoform 1 of Cathelicidin 1 OS=Bos taurus OX=9913 GN=CATHL1 PE=3 SV=1 CANONICAL=A0AAF6YSZ8-1" }, "locus": { "chromosome": "22", "start_pos": 51601080, "end_pos": 51599770, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011364.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011364.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011364.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011364.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282164", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282164", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YSZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YSZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSZ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YT25-1", "uniprot_ac": "A0AAF6YT25", "uniprot_id": "A0AAF6YT25_BOVIN", "mass": { "chemical_mass": 17706.0, "monoisotopic_mass": 17706.0 }, "refseq": {}, "gene_names": [ { "name": "FAM136A", "type": "recommended", "evidence": [ { "id": "A0AAF6YT25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25" } ] } ], "protein_names": [ { "name": "Protein FAM136A", "type": "recommended", "evidence": [ { "id": "A0AAF6YT25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YT25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM136A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25", "locus": { "chromosome": "11", "start_pos": 14154627, "end_pos": 14150122, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008674", "url": "https://www.ensembl.org/id/ENSBTAG00000008674" } ] } } ], "crossref": [ { "id": "A0AAF6YT25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YT25", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21096", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21096", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21096:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21096:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YT25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YT25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGRPCGRRRSREPRVAMAELQQLRVQEAVDSMVKSLERENIRKMQGLMFRCSAACCEESQASMQQVHQCIERCHAPLAQAQALVTSELEKFQDRLARCTMYCNDKAKDSIDAGSKELHVKRQLETCVTKCVDDHMNLIPTMTRKMKESLSSIGK", "length": 155, "header": "tr|A0AAF6YT25-1|A0AAF6YT25_BOVIN Isoform 1 of Protein FAM136A OS=Bos taurus OX=9913 GN=FAM136A PE=3 SV=1 CANONICAL=A0AAF6YT25-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YT25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT25/entry", "sequence": { "sequence": "MRGRPCGRRRSREPRVAMAELQQLRVQEAVDSMVKSLERENIRKMQGLMFRCSAACCEESQASMQQVHQCIERCHAPLAQAQALVTSELEKFQDRLARCTMYCNDKAKDSIDAGSKELHVKRQLETCVTKCVDDHMNLIPTMTRKMKESLSSIGK", "length": 155, "header": "tr|A0AAF6YT25-1|A0AAF6YT25_BOVIN Isoform 1 of Protein FAM136A OS=Bos taurus OX=9913 GN=FAM136A PE=3 SV=1 CANONICAL=A0AAF6YT25-1" }, "locus": { "chromosome": "11", "start_pos": 14153321, "end_pos": 14150174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011436.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011436.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011436.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011436.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YTE2-1", "uniprot_ac": "A0AAF6YTE2", "uniprot_id": "A0AAF6YTE2_BOVIN", "mass": { "chemical_mass": 56917.0, "monoisotopic_mass": 56917.0 }, "refseq": {}, "gene_names": [ { "name": "NSDHL", "type": "recommended", "evidence": [ { "id": "A0AAF6YTE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ] } ], "protein_names": [ { "name": "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "type": "recommended", "evidence": [ { "id": "A0AAF6YTE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.170", "type": "synonym", "evidence": [ { "id": "A0AAF6YTE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NSDHL", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2", "locus": { "chromosome": "X", "start_pos": 35159670, "end_pos": 35133126, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009231", "url": "https://www.ensembl.org/id/ENSBTAG00000009231" } ] } } ], "crossref": [ { "id": "A0AAF6YTE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YTE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09813", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09813", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43245:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43245:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "33447", "url": "https://www.rhea-db.org/rhea/33447", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33455", "url": "https://www.rhea-db.org/rhea/33455", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34771", "url": "https://www.rhea-db.org/rhea/34771", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34775", "url": "https://www.rhea-db.org/rhea/34775", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46828", "url": "https://www.rhea-db.org/rhea/46828", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46848", "url": "https://www.rhea-db.org/rhea/46848", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47160", "url": "https://www.rhea-db.org/rhea/47160", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47164", "url": "https://www.rhea-db.org/rhea/47164", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47168", "url": "https://www.rhea-db.org/rhea/47168", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47172", "url": "https://www.rhea-db.org/rhea/47172", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK50", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK50-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGSRPKQALTIPDGFHFPLLRQPTYTPTQRRSHRPARVASLPIGGPLAAAPHWLRAGVGGANPTNTRHRAGGSILAARPHWAGLHRERRLVEPAPNLANPLGGGASADPRLTRAGRKRWLPAARALRVQAVDTLGPTSGAPTDRRQTLIADRATFGAKMEQAAGEPTRTCLTEDIPKAKRCTVIGGCGFLGQHMVEQLLARGYAVNVFDIRQGFDNPRVQFFLGDLCSQQDLYPALKGVSTVFHCASPPPFNNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYATKPIDYYTETKILQERAVLGAHDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAAKKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSQDTALGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWLAYYLALLVSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCEKAKKLMGYRPLVTMDDAVDKTVRSFHHLRKVM", "length": 515, "header": "tr|A0AAF6YTE2-1|A0AAF6YTE2_BOVIN Isoform 1 of Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Bos taurus OX=9913 GN=NSDHL PE=3 SV=1 CANONICAL=A0AAF6YTE2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YTE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2/entry", "sequence": { "sequence": "MRGSRPKQALTIPDGFHFPLLRQPTYTPTQRRSHRPARVASLPIGGPLAAAPHWLRAGVGGANPTNTRHRAGGSILAARPHWAGLHRERRLVEPAPNLANPLGGGASADPRLTRAGRKRWLPAARALRVQAVDTLGPTSGAPTDRRQTLIADRATFGAKMEQAAGEPTRTCLTEDIPKAKRCTVIGGCGFLGQHMVEQLLARGYAVNVFDIRQGFDNPRVQFFLGDLCSQQDLYPALKGVSTVFHCASPPPFNNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYATKPIDYYTETKILQERAVLGAHDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAAKKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSQDTALGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWLAYYLALLVSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCEKAKKLMGYRPLVTMDDAVDKTVRSFHHLRKVM", "length": 515, "header": "tr|A0AAF6YTE2-1|A0AAF6YTE2_BOVIN Isoform 1 of Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Bos taurus OX=9913 GN=NSDHL PE=3 SV=1 CANONICAL=A0AAF6YTE2-1" }, "locus": { "chromosome": "X", "start_pos": 35158685, "end_pos": 35133325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012167.5", "url": "https://www.ensembl.org/id/ENSBTAT00000012167.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012167.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012167.4" } ] } }, { "isoform_ac": "A0ABI0NK50-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK50/entry", "sequence": { "sequence": "MEQAAGEPTRTCLTEDIPKAKRCTVIGGCGFLGQHMVEQLLARGYAVNVFDIRQGFDNPRVQFFLGDLCSQQDLYPALKGVSTVFHCASPPPFNNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYATKPIDYYTETKILQERGIASFKLHAAAKSLYSCPTLCDPRDGSPPGSPVPGILQAVLGAHDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAAKKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSQDTALGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWLAYYLALLVSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCEKAKKLMGYRPLVTMDDAVDKTVRSFHHLRKVM", "length": 394, "header": "tr|A0ABI0NK50-1|A0ABI0NK50_BOVIN Computationally mapped isoform of NAD(P) dependent steroid dehydrogenase-like OS=Bos taurus OX=9913 GN=NSDHL PE=3 SV=1 CANONICAL=A0AAF6YTE2-1" }, "locus": { "chromosome": "X", "start_pos": 35158685, "end_pos": 35140802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154561.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154561.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104970.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 138, "start_aa": "Thr", "end_pos": 138, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr138", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cholesterol biosynthetic process via desmosterol", "id": "GO:0033489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033489", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via lathosterol", "id": "GO:0033490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033490", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" }, { "name": "zymosterol biosynthetic process", "id": "GO:0036197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" }, { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity", "id": "GO:0000252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33447", "name": "", "equation": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "33447", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33447" } ] }, { "id": "33455", "name": "", "equation": "4alpha-carboxyzymosterol + NADP(+) = zymosterone + CO2 + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "33455", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33455" } ] }, { "id": "34771", "name": "", "equation": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "34771", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34771" } ] }, { "id": "34775", "name": "", "equation": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "34775", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34775" } ] }, { "id": "46828", "name": "", "equation": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "46828", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46828" } ] }, { "id": "46848", "name": "", "equation": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "46848", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46848" } ] }, { "id": "47160", "name": "", "equation": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "47160", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47160" } ] }, { "id": "47164", "name": "", "equation": "4alpha-carboxyzymosterol + NAD(+) = zymosterone + CO2 + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "47164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47164" } ] }, { "id": "47168", "name": "", "equation": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "47168", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47168" } ] }, { "id": "47172", "name": "", "equation": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBE9-1", "A0AAF6YTE2-1" ], "evidence": [ { "id": "47172", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47172" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YTE2", "gene_name": "NSDHL", "activity": [ { "ec_number": "1.1.1.170", "activity": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH.", "evidence": [ { "id": "A0AAF6YTE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ] }, { "ec_number": "1.1.1.170", "activity": "", "evidence": [ { "id": "A0AAF6YTE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" } ] } ] }, { "uniprot_ac": "Q3ZBE9", "gene_name": "NSDHL", "activity": [ { "ec_number": "1.1.1.170", "activity": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH.", "evidence": [ { "id": "Q3ZBE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE9" } ] }, { "ec_number": "1.1.1.170", "activity": "", "evidence": [ { "id": "Q3ZBE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YTE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE2" }, { "id": "PF01073", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01073" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3-beta hydroxysteroid dehydrogenase/isomerase", "eco_id": "ECO_0000259", "start_pos": 184, "end_pos": 434, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.170", "ec_name": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH.", "evidence": [ { "id": "1.1.1.170", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.170" }, { "id": "1.1.1.170", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.170" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 138 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YTF7-1", "uniprot_ac": "A0AAF6YTF7", "uniprot_id": "A0AAF6YTF7_BOVIN", "mass": { "chemical_mass": 39067.0, "monoisotopic_mass": 39067.0 }, "refseq": { "ac": "XP_005218221", "name": "developmentally-regulated GTP-binding protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218221" }, "gene_names": [ { "name": "DRG1", "type": "recommended", "evidence": [ { "id": "A0AAF6YTF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ] }, { "name": "DRG1", "type": "synonym", "evidence": [ { "id": "XP_005218221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218221" } ] }, { "name": "NEDD-3", "type": "synonym", "evidence": [ { "id": "XP_005218221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218221" } ] } ], "protein_names": [ { "name": "Developmentally-regulated GTP-binding protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6YTF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7/entry#names_and_taxonomy" } ] }, { "name": "Neural precursor cell expressed developmentally down-regulated protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6YTF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7/entry#names_and_taxonomy" } ] }, { "name": "Translation factor GTPase DRG1", "type": "synonym", "evidence": [ { "id": "A0AAF6YTF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7/entry#names_and_taxonomy" } ] }, { "name": "developmentally-regulated GTP-binding protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218221" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRG1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7", "locus": { "chromosome": "17", "start_pos": 70184876, "end_pos": 70170017, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008990", "url": "https://www.ensembl.org/id/ENSBTAG00000008990" } ] } } ], "crossref": [ { "id": "A0AAF6YTF7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YTF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01896", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01896", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17230", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17230", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540161", "url": "https://www.ncbi.nlm.nih.gov/gene/540161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02824", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02824", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16897", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16897", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218221", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218221", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK", "length": 353, "header": "tr|A0AAF6YTF7-1|A0AAF6YTF7_BOVIN Isoform 1 of Developmentally-regulated GTP-binding protein 1 OS=Bos taurus OX=9913 GN=DRG1 PE=4 SV=1 CANONICAL=A0AAF6YTF7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YTF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7/entry", "sequence": { "sequence": "MARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK", "length": 353, "header": "tr|A0AAF6YTF7-1|A0AAF6YTF7_BOVIN Isoform 1 of Developmentally-regulated GTP-binding protein 1 OS=Bos taurus OX=9913 GN=DRG1 PE=4 SV=1 CANONICAL=A0AAF6YTF7-1" }, "locus": { "chromosome": "17", "start_pos": 70184663, "end_pos": 70170955, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011834.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011834.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011834.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011834.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" }, { "name": "potassium ion binding", "id": "GO:0030955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030955", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of microtubule polymerization", "id": "GO:0031116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031116", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" }, { "name": "regulation of mitotic spindle assembly", "id": "GO:1901673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901673", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YTF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YTF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" }, { "id": "PS51710", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51710" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OBG-type G", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 276, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YTF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTF7" }, { "id": "PS51880", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51880" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TGS", "eco_id": "ECO_0000259", "start_pos": 276, "end_pos": 352, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUC8-1", "uniprot_ac": "A0AAF6YUC8", "uniprot_id": "A0AAF6YUC8_BOVIN", "mass": { "chemical_mass": 42101.0, "monoisotopic_mass": 42101.0 }, "refseq": {}, "gene_names": [ { "name": "PGP", "type": "recommended", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ], "protein_names": [ { "name": "Glycerol-3-phosphate phosphatase", "type": "recommended", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.21", "type": "synonym", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8/entry#names_and_taxonomy" } ] }, { "name": "Aspartate-based ubiquitous Mg(2+)-dependent phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8/entry#names_and_taxonomy" } ] }, { "name": "Phosphoglycolate phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8#function" }, { "database": "UniProtKB", "id": "ARBA00057228", "url": "https://www.uniprot.org/uniprotkb/ARBA00057228#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8", "locus": { "chromosome": "25", "start_pos": 1742546, "end_pos": 1745683, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009951", "url": "https://www.ensembl.org/id/ENSBTAG00000009951" } ] } } ], "crossref": [ { "id": "A0AAF6YUC8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19288:SF92", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19288:SF92", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13242", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13242", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46084", "url": "https://www.rhea-db.org/rhea/46084", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66372", "url": "https://www.rhea-db.org/rhea/66372", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARLSAADRDGWPGAPAARGRRGRIGAGGAQWATRARRGAYERAGGGAGPAAGGCEEERPAGGGGGGRWRRRRRAAMAEAEAGGDDGRCVRLNAERAQALLADVDTLLFDCDGVLWRGETAVPGAPETLTALRARGKRLAFITNNSSKTREAYAEKLRCLGFGAPAGPDAGREVFGTAYCTALYLRQRLTGPPAPKAYVLGSVALAAELEAVGVSCVGVGPEPLLGDGPGAWLDAPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGIHPERTVMVGDRLDTDILLGVTCGLKTILTLTGVSSLRDVKSNQESDCMAKKKMVPDFYVDSIADLLPALQG", "length": 398, "header": "tr|A0AAF6YUC8-1|A0AAF6YUC8_BOVIN Isoform 1 of Glycerol-3-phosphate phosphatase OS=Bos taurus OX=9913 GN=PGP PE=3 SV=1 CANONICAL=A0AAF6YUC8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8/entry", "sequence": { "sequence": "MAARLSAADRDGWPGAPAARGRRGRIGAGGAQWATRARRGAYERAGGGAGPAAGGCEEERPAGGGGGGRWRRRRRAAMAEAEAGGDDGRCVRLNAERAQALLADVDTLLFDCDGVLWRGETAVPGAPETLTALRARGKRLAFITNNSSKTREAYAEKLRCLGFGAPAGPDAGREVFGTAYCTALYLRQRLTGPPAPKAYVLGSVALAAELEAVGVSCVGVGPEPLLGDGPGAWLDAPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGIHPERTVMVGDRLDTDILLGVTCGLKTILTLTGVSSLRDVKSNQESDCMAKKKMVPDFYVDSIADLLPALQG", "length": 398, "header": "tr|A0AAF6YUC8-1|A0AAF6YUC8_BOVIN Isoform 1 of Glycerol-3-phosphate phosphatase OS=Bos taurus OX=9913 GN=PGP PE=3 SV=1 CANONICAL=A0AAF6YUC8-1" }, "locus": { "chromosome": "25", "start_pos": 1745551, "end_pos": 1744259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013127.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013127.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013127.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013127.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "glycerophospholipid metabolic process", "id": "GO:0006650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006650", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" }, { "name": "glycerol biosynthetic process", "id": "GO:0006114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006114", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" }, { "name": "negative regulation of gluconeogenesis", "id": "GO:0045721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045721", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" }, { "name": "phosphoglycolate phosphatase activity", "id": "GO:0008967", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008967", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" }, { "name": "ADP phosphatase activity", "id": "GO:0043262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043262", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" }, { "name": "sn-glycerol 3-phosphatase activity", "id": "GO:0043136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043136", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "46084", "name": "", "equation": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUC8-1", "Q2T9S4-1" ], "evidence": [ { "id": "46084", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46084" } ] }, { "id": "66372", "name": "", "equation": "sn-glycerol 3-phosphate + H2O = glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUC8-1", "Q2T9S4-1" ], "evidence": [ { "id": "66372", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66372" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.21", "ec_name": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "3.1.3.21", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21" }, { "id": "3.1.3.21", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.21" } ] }, { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 146, "end_pos": 148 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUE3-1", "uniprot_ac": "A0AAF6YUE3", "uniprot_id": "A0AAF6YUE3_BOVIN", "mass": { "chemical_mass": 34646.0, "monoisotopic_mass": 34646.0 }, "refseq": {}, "gene_names": [ { "name": "CRYM", "type": "recommended", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ] } ], "protein_names": [ { "name": "Ketimine reductase mu-crystallin", "type": "recommended", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3/entry#names_and_taxonomy" } ] }, { "name": "1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase", "type": "synonym", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3/entry#names_and_taxonomy" } ] }, { "name": "1.5.1.1", "type": "synonym", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3/entry#names_and_taxonomy" } ] }, { "name": "1.5.1.25", "type": "synonym", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3/entry#names_and_taxonomy" } ] }, { "name": "NADP-regulated thyroid-hormone-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRYM", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3", "locus": { "chromosome": "25", "start_pos": 19074614, "end_pos": 19098173, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009842", "url": "https://www.ensembl.org/id/ENSBTAG00000009842" } ] } } ], "crossref": [ { "id": "A0AAF6YUE3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13812", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13812", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13812:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13812:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "12500", "url": "https://www.rhea-db.org/rhea/12500", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "12504", "url": "https://www.rhea-db.org/rhea/12504", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "12524", "url": "https://www.rhea-db.org/rhea/12524", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20317", "url": "https://www.rhea-db.org/rhea/20317", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20321", "url": "https://www.rhea-db.org/rhea/20321", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "30807", "url": "https://www.rhea-db.org/rhea/30807", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68032", "url": "https://www.rhea-db.org/rhea/68032", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68036", "url": "https://www.rhea-db.org/rhea/68036", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68040", "url": "https://www.rhea-db.org/rhea/68040", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68072", "url": "https://www.rhea-db.org/rhea/68072", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSRPVFLSAADVQDHLRSSSLLIAPLETALANFSSGPDGGVVQPVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEDHSATSTVPSHQATVLLFQPSNGSLLAVMDGNVITAKRTAAVSAIATKFLKPPNSEVLCILGAGVQAYSHYEVFTEQFFFKEVRIWNRTKENAEKFVNTVPGEVRICSSVQEAVTGADVIITVTMATEPILFGEWVKPGAHINAIGASRPDWRELDDELMKQAVLYVDSQEAALKESGDVLLSGAEIFAELGEVVKGVKPAHCEKTTVFKSLGKSHCSQGTNLTRTQEWRWKTWLQPN", "length": 319, "header": "tr|A0AAF6YUE3-1|A0AAF6YUE3_BOVIN Isoform 1 of Ketimine reductase mu-crystallin OS=Bos taurus OX=9913 GN=CRYM PE=3 SV=1 CANONICAL=A0AAF6YUE3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3/entry", "sequence": { "sequence": "MSSRPVFLSAADVQDHLRSSSLLIAPLETALANFSSGPDGGVVQPVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEDHSATSTVPSHQATVLLFQPSNGSLLAVMDGNVITAKRTAAVSAIATKFLKPPNSEVLCILGAGVQAYSHYEVFTEQFFFKEVRIWNRTKENAEKFVNTVPGEVRICSSVQEAVTGADVIITVTMATEPILFGEWVKPGAHINAIGASRPDWRELDDELMKQAVLYVDSQEAALKESGDVLLSGAEIFAELGEVVKGVKPAHCEKTTVFKSLGKSHCSQGTNLTRTQEWRWKTWLQPN", "length": 319, "header": "tr|A0AAF6YUE3-1|A0AAF6YUE3_BOVIN Isoform 1 of Ketimine reductase mu-crystallin OS=Bos taurus OX=9913 GN=CRYM PE=3 SV=1 CANONICAL=A0AAF6YUE3-1" }, "locus": { "chromosome": "25", "start_pos": 19098089, "end_pos": 19074937, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012972.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012972.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012972.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012972.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "thiomorpholine-carboxylate dehydrogenase activity", "id": "GO:0047127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047127", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ], "pmid": "" }, { "name": "hormone binding", "id": "GO:0042562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042562", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ], "pmid": "" }, { "name": "pyrroline-2-carboxylate reductase activity", "id": "GO:0050241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050241", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12500", "name": "", "equation": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUE3-1", "Q2KHX6-1" ], "evidence": [ { "id": "12500", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12500" } ] }, { "id": "12504", "name": "", "equation": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADH + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUE3-1", "Q2KHX6-1" ], "evidence": [ { "id": "12504", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12504" } ] }, { "id": "12524", "name": "", "equation": "L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "12524", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12524" } ] }, { "id": "20317", "name": "", "equation": "L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "20317", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20317" } ] }, { "id": "20321", "name": "", "equation": "L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "20321", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20321" } ] }, { "id": "30807", "name": "", "equation": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "30807", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30807" } ] }, { "id": "68032", "name": "", "equation": "(S)-cystathionine ketimine + NADH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "68032", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68032" } ] }, { "id": "68036", "name": "", "equation": "(S)-cystathionine ketimine + NADPH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "68036", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68036" } ] }, { "id": "68040", "name": "", "equation": "(R)-lanthionine ketimine + NADPH + 2 H(+) = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "68040", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68040" } ] }, { "id": "68072", "name": "", "equation": "Delta(2)-thiazoline-2-carboxylate + NADPH + 2 H(+) = L-thiazolidine-2-carboxylate + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KHX6-1", "A0AAF6YUE3-1" ], "evidence": [ { "id": "68072", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68072" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YUE3", "gene_name": "CRYM", "activity": [ { "ec_number": "1.5.1.25", "activity": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+).", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ] }, { "ec_number": "1.5.1.1", "activity": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+).", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ] }, { "ec_number": "1.5.1.1", "activity": "", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ] }, { "ec_number": "1.5.1.25", "activity": "", "evidence": [ { "id": "A0AAF6YUE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUE3" } ] } ] }, { "uniprot_ac": "Q2KHX6", "gene_name": "CRYM", "activity": [ { "ec_number": "1.5.1.25", "activity": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+).", "evidence": [ { "id": "Q2KHX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX6" } ] }, { "ec_number": "1.5.1.1", "activity": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+).", "evidence": [ { "id": "Q2KHX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX6" } ] }, { "ec_number": "1.5.1.25", "activity": "", "evidence": [ { "id": "Q2KHX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHX6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.5.1.25", "ec_name": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+).", "evidence": [ { "id": "1.5.1.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.25" }, { "id": "1.5.1.25", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.25" } ] }, { "ec_number": "1.5.1.1", "ec_name": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+).", "evidence": [ { "id": "1.5.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.1" }, { "id": "1.5.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.1" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 168, "end_pos": 170 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUF4-1", "uniprot_ac": "A0AAF6YUF4", "uniprot_id": "A0AAF6YUF4_BOVIN", "mass": { "chemical_mass": 26517.0, "monoisotopic_mass": 26517.0 }, "refseq": {}, "gene_names": [ { "name": "NAP1L5", "type": "recommended", "evidence": [ { "id": "A0AAF6YUF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4" } ] } ], "protein_names": [ { "name": "Nucleosome assembly protein 1 like 5", "type": "synonym", "evidence": [ { "id": "A0AAF6YUF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAP1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4", "locus": { "chromosome": "6", "start_pos": 36084996, "end_pos": 36082066, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010128", "url": "https://www.ensembl.org/id/ENSBTAG00000010128" } ] } } ], "crossref": [ { "id": "A0AAF6YUF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11875", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11875", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSQSRARGGKGRGRATSPPRPTSEPLAACRSRKIAVVQLGCRSLWEPPRTLRCSSNMADSQNQGSAEPSQAAAAAAAADAAAAAEEVMAEGGAQGGDSDSASSDSDGVVGQMAEEPQTPAENAPKPRNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGDEEDDDDDEYEDEEEGEEEDEEEEEPAAEAAGTAAAKDEGPHSAVPDDAKK", "length": 249, "header": "tr|A0AAF6YUF4-1|A0AAF6YUF4_BOVIN Isoform 1 of Nucleosome assembly protein 1 like 5 OS=Bos taurus OX=9913 GN=NAP1L5 PE=3 SV=1 CANONICAL=A0AAF6YUF4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4/entry", "sequence": { "sequence": "MGSQSRARGGKGRGRATSPPRPTSEPLAACRSRKIAVVQLGCRSLWEPPRTLRCSSNMADSQNQGSAEPSQAAAAAAAADAAAAAEEVMAEGGAQGGDSDSASSDSDGVVGQMAEEPQTPAENAPKPRNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGDEEDDDDDEYEDEEEGEEEDEEEEEPAAEAAGTAAAKDEGPHSAVPDDAKK", "length": 249, "header": "tr|A0AAF6YUF4-1|A0AAF6YUF4_BOVIN Isoform 1 of Nucleosome assembly protein 1 like 5 OS=Bos taurus OX=9913 GN=NAP1L5 PE=3 SV=1 CANONICAL=A0AAF6YUF4-1" }, "locus": { "chromosome": "6", "start_pos": 36083434, "end_pos": 36082688, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013363.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013363.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013363.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013363.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUG4-1", "uniprot_ac": "A0AAF6YUG4", "uniprot_id": "A0AAF6YUG4_BOVIN", "mass": { "chemical_mass": 10044.0, "monoisotopic_mass": 10044.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "C-C motif chemokine", "type": "recommended", "evidence": [ { "id": "A0AAF6YUG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4", "locus": {} } ], "crossref": [ { "id": "A0AAF6YUG4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00272", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00272", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015:SF149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015:SF149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FKWFSLALYFHLTVLYLAEPAGNMRVCCFSSVTRKIPLSLVKNYERTGDKCPQEAVIFQTRSGRSICANPGQAWVQKYIEYLDQMSK", "length": 87, "header": "tr|A0AAF6YUG4-1|A0AAF6YUG4_BOVIN Isoform 1 of C-C motif chemokine OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YUG4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4/entry", "sequence": { "sequence": "FKWFSLALYFHLTVLYLAEPAGNMRVCCFSSVTRKIPLSLVKNYERTGDKCPQEAVIFQTRSGRSICANPGQAWVQKYIEYLDQMSK", "length": 87, "header": "tr|A0AAF6YUG4-1|A0AAF6YUG4_BOVIN Isoform 1 of C-C motif chemokine OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YUG4-1" }, "locus": { "chromosome": "19", "start_pos": 14427356, "end_pos": 14426016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013399.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013399.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013399.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013399.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUG4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUG4" }, { "id": "SM00199", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chemokine interleukin-8-like", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 82, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUI9-1", "uniprot_ac": "A0AAF6YUI9", "uniprot_id": "A0AAF6YUI9_BOVIN", "mass": { "chemical_mass": 89003.0, "monoisotopic_mass": 89003.0 }, "refseq": {}, "gene_names": [ { "name": "CPSF2", "type": "recommended", "evidence": [ { "id": "A0AAF6YUI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ] } ], "protein_names": [ { "name": "Cleavage and polyadenylation specificity factor subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAF6YUI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9/entry#names_and_taxonomy" } ] }, { "name": "Cleavage and polyadenylation specificity factor 100 kDa subunit", "type": "synonym", "evidence": [ { "id": "A0AAF6YUI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9#function" }, { "database": "UniProtKB", "id": "ARBA00059189", "url": "https://www.uniprot.org/uniprotkb/ARBA00059189#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPSF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9", "locus": { "chromosome": "21", "start_pos": 56842217, "end_pos": 56809062, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010227", "url": "https://www.ensembl.org/id/ENSBTAG00000010227" } ] } } ], "crossref": [ { "id": "A0AAF6YUI9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45922", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45922", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45922:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45922:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13299", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13299", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDAEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKGLLFRPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 787, "header": "tr|A0AAF6YUI9-1|A0AAF6YUI9_BOVIN Isoform 1 of Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus OX=9913 GN=CPSF2 PE=3 SV=1 CANONICAL=A0AAF6YUI9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9/entry", "sequence": { "sequence": "MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDAEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKGLLFRPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV", "length": 787, "header": "tr|A0AAF6YUI9-1|A0AAF6YUI9_BOVIN Isoform 1 of Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus OX=9913 GN=CPSF2 PE=3 SV=1 CANONICAL=A0AAF6YUI9-1" }, "locus": { "chromosome": "21", "start_pos": 56841129, "end_pos": 56818208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013500.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013500.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013500.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013500.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ], "pmid": "" }, { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA 3'-end processing by stem-loop binding and cleavage", "id": "GO:0006398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006398", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUI9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" }, { "id": "SM01027", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01027" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta-Casp", "eco_id": "ECO_0000259", "start_pos": 243, "end_pos": 368, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YUI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUI9" }, { "id": "SM00849", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Metallo-beta-lactamase", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 223, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 271, "end_pos": 273 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUL5-1", "uniprot_ac": "A0AAF6YUL5", "uniprot_id": "A0AAF6YUL5_BOVIN", "mass": { "chemical_mass": 66005.0, "monoisotopic_mass": 66005.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF181", "type": "recommended", "evidence": [ { "id": "A0AAF6YUL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ] } ], "protein_names": [ { "name": "Zinc finger protein 181", "type": "recommended", "evidence": [ { "id": "A0AAF6YUL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF181", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5", "locus": { "chromosome": "18", "start_pos": 45526105, "end_pos": 45515472, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009889", "url": "https://www.ensembl.org/id/ENSBTAG00000009889" } ] } } ], "crossref": [ { "id": "A0AAF6YUL5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFQVTFSDVAIDFSHEEWRWLNSTQRNLYKDVMVQNYENLVSLAGLSIPKPYVIALLEDGKEPCMVEEKLSKDTFPDCKTRWENKELSMKEDIYDEDLPQMVLKEKTIQQNHEFSNFNKDLYYIKKFKGKYENQVEHFRPVTLTFRESPIGESVYKCNAFKSIFHLKSVFSEPQRISAEGKSHKCDILKKSLPTNSVIKNENINDGKKLLNSNESVAAFSQSKSLTLHQTLNKEKIYTCNECGKAFGKQSILNRHWRIHTGEKPYECHECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHVSSLTNHQSTHTGEKPYECMNCGKAFSRVSHLIEHLRIHTQEKLYECRICGKAFIHRSSLIHHQKIHTGEKPYECRECGKAFCCSSHLTRHQRIHAIEKQFECNKCLKVFSSLSFLIQHQSIHTEEKPFECQKCGKSFNQPESLNMHLRNHTRLKPYECSICGKAFSHRSSLFQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKAFSKGSNLTAHQRVHNGEKPSSTISVEKSLGHMSHCVYERSHNRETA", "length": 571, "header": "tr|A0AAF6YUL5-1|A0AAF6YUL5_BOVIN Isoform 1 of Zinc finger protein 181 OS=Bos taurus OX=9913 GN=ZNF181 PE=3 SV=1 CANONICAL=A0AAF6YUL5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5/entry", "sequence": { "sequence": "MFQVTFSDVAIDFSHEEWRWLNSTQRNLYKDVMVQNYENLVSLAGLSIPKPYVIALLEDGKEPCMVEEKLSKDTFPDCKTRWENKELSMKEDIYDEDLPQMVLKEKTIQQNHEFSNFNKDLYYIKKFKGKYENQVEHFRPVTLTFRESPIGESVYKCNAFKSIFHLKSVFSEPQRISAEGKSHKCDILKKSLPTNSVIKNENINDGKKLLNSNESVAAFSQSKSLTLHQTLNKEKIYTCNECGKAFGKQSILNRHWRIHTGEKPYECHECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHVSSLTNHQSTHTGEKPYECMNCGKAFSRVSHLIEHLRIHTQEKLYECRICGKAFIHRSSLIHHQKIHTGEKPYECRECGKAFCCSSHLTRHQRIHAIEKQFECNKCLKVFSSLSFLIQHQSIHTEEKPFECQKCGKSFNQPESLNMHLRNHTRLKPYECSICGKAFSHRSSLFQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKAFSKGSNLTAHQRVHNGEKPSSTISVEKSLGHMSHCVYERSHNRETA", "length": 571, "header": "tr|A0AAF6YUL5-1|A0AAF6YUL5_BOVIN Isoform 1 of Zinc finger protein 181 OS=Bos taurus OX=9913 GN=ZNF181 PE=3 SV=1 CANONICAL=A0AAF6YUL5-1" }, "locus": { "chromosome": "18", "start_pos": 45525379, "end_pos": 45516577, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013039.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013039.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013039.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013039.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 531, "end_pos": 533, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 264, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YUL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUL5" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 76, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 }, { "start_pos": 22, "end_pos": 24 }, { "start_pos": 454, "end_pos": 456 }, { "start_pos": 503, "end_pos": 505 }, { "start_pos": 531, "end_pos": 533 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUM5-1", "uniprot_ac": "A0AAF6YUM5", "uniprot_id": "A0AAF6YUM5_BOVIN", "mass": { "chemical_mass": 15127.0, "monoisotopic_mass": 15127.0 }, "refseq": {}, "gene_names": [ { "name": "GOLT1A", "type": "recommended", "evidence": [ { "id": "A0AAF6YUM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ] } ], "protein_names": [ { "name": "Golgi transport 1A", "type": "synonym", "evidence": [ { "id": "A0AAF6YUM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in fusion of ER-derived transport vesicles with the Golgi complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5#function" }, { "database": "UniProtKB", "id": "ARBA00024660", "url": "https://www.uniprot.org/uniprotkb/ARBA00024660#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLT1A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5", "locus": { "chromosome": "16", "start_pos": 1964614, "end_pos": 1968444, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010177", "url": "https://www.ensembl.org/id/ENSBTAG00000010177" } ] } } ], "crossref": [ { "id": "A0AAF6YUM5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21493:SF245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21493:SF245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TTLIMIWQRRKIGVGTTGFGIFFILFGMLLYFDSVLLAFGNLLFLTGLSLIIGLRRTFSFFFQRHKFKGTSFFLGGVVIVLLRWPLLGMCLETYGFFSLFRGFFPVAFGFLGSASNIPFLSALFQRLQGTSSMV", "length": 134, "header": "tr|A0AAF6YUM5-1|A0AAF6YUM5_BOVIN Isoform 1 of Golgi transport 1A OS=Bos taurus OX=9913 GN=GOLT1A PE=3 SV=1 CANONICAL=A0AAF6YUM5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5/entry", "sequence": { "sequence": "TTLIMIWQRRKIGVGTTGFGIFFILFGMLLYFDSVLLAFGNLLFLTGLSLIIGLRRTFSFFFQRHKFKGTSFFLGGVVIVLLRWPLLGMCLETYGFFSLFRGFFPVAFGFLGSASNIPFLSALFQRLQGTSSMV", "length": 134, "header": "tr|A0AAF6YUM5-1|A0AAF6YUM5_BOVIN Isoform 1 of Golgi transport 1A OS=Bos taurus OX=9913 GN=GOLT1A PE=3 SV=1 CANONICAL=A0AAF6YUM5-1" }, "locus": { "chromosome": "16", "start_pos": 1968444, "end_pos": 1964878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013429.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013429.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013429.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013429.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" }, { "name": "Golgi cis cisterna", "id": "GO:0000137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000137", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUM7-1", "uniprot_ac": "A0AAF6YUM7", "uniprot_id": "A0AAF6YUM7_BOVIN", "mass": { "chemical_mass": 35750.0, "monoisotopic_mass": 35750.0 }, "refseq": {}, "gene_names": [ { "name": "RDH8", "type": "recommended", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ] } ], "protein_names": [ { "name": "Retinol dehydrogenase", "type": "recommended", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.300", "type": "synonym", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7#function" }, { "database": "UniProtKB", "id": "PIRNR000095", "url": "https://www.uniprot.org/uniprotkb/PIRNR000095#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RDH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7", "locus": { "chromosome": "7", "start_pos": 14596077, "end_pos": 14589588, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010188", "url": "https://www.ensembl.org/id/ENSBTAG00000010188" } ] } } ], "crossref": [ { "id": "A0AAF6YUM7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09806", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09806", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43391", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43391", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43391:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43391:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "25033", "url": "https://www.rhea-db.org/rhea/25033", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TGGGSQLLASGGHASREINMADAPRTVLISGCSSGIGLELAVQLAHDPRQRYQVVATMRDLGKKGTLETAAGEALGQTLTVAQLDVCSDESVAQCLNCIQGGEVDVLVNNAGVGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPSMKRRRQGHIVVVSSVMGLQGVVFNEVYAASKFAMEGFFESLAVQLLQFNIFISLVEPGPVVTEFEGKLLEQVSTAEFPGTDPDTLSYFRDLYLPASRELFHNVGQSPQDVAKVIVKVIGSARPPLRRRTNTRYTPLIALKAMDPSGSLYVRTSHCLLFRWPRLLNLGLRCLACSCFRTPVWPR", "length": 331, "header": "tr|A0AAF6YUM7-1|A0AAF6YUM7_BOVIN Isoform 1 of Retinol dehydrogenase OS=Bos taurus OX=9913 GN=RDH8 PE=3 SV=1 CANONICAL=A0AAF6YUM7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7/entry", "sequence": { "sequence": "TGGGSQLLASGGHASREINMADAPRTVLISGCSSGIGLELAVQLAHDPRQRYQVVATMRDLGKKGTLETAAGEALGQTLTVAQLDVCSDESVAQCLNCIQGGEVDVLVNNAGVGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPSMKRRRQGHIVVVSSVMGLQGVVFNEVYAASKFAMEGFFESLAVQLLQFNIFISLVEPGPVVTEFEGKLLEQVSTAEFPGTDPDTLSYFRDLYLPASRELFHNVGQSPQDVAKVIVKVIGSARPPLRRRTNTRYTPLIALKAMDPSGSLYVRTSHCLLFRWPRLLNLGLRCLACSCFRTPVWPR", "length": 331, "header": "tr|A0AAF6YUM7-1|A0AAF6YUM7_BOVIN Isoform 1 of Retinol dehydrogenase OS=Bos taurus OX=9913 GN=RDH8 PE=3 SV=1 CANONICAL=A0AAF6YUM7-1" }, "locus": { "chromosome": "7", "start_pos": 14595247, "end_pos": 14589588, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013443.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013443.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013443.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013443.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "all-trans-retinol dehydrogenase (NAD+) activity", "id": "GO:0004745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004745", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "pmid": "" }, { "name": "estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "id": "GO:0004303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004303", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "pmid": "" }, { "name": "all-trans-retinol dehydrogenase (NADP+) activity", "id": "GO:0052650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052650", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "estrogen biosynthetic process", "id": "GO:0006703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006703", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUM7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25033", "name": "", "equation": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUM7-1", "A0A493UA87-1", "Q8SPU8-1", "P59837-1", "P16116-1", "Q17QW3-1", "Q8HZT6-1", "Q9N126-1", "O77769-1", "E1BM93-1", "F1MD39-1", "F1N334-1" ], "evidence": [ { "id": "25033", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25033" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A493UA87", "gene_name": "AKR1B1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.21", "activity": "L-arabinitol + NADP(+) = L-arabinose + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] } ] }, { "uniprot_ac": "A0AAF6YUM7", "gene_name": "RDH8", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ] } ] }, { "uniprot_ac": "E1BM93", "gene_name": "RDH11", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "E1BM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM93" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "E1BM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM93" } ] } ] }, { "uniprot_ac": "F1MD39", "gene_name": "RDH12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "F1MD39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD39" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "F1MD39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD39" } ] } ] }, { "uniprot_ac": "F1N334", "gene_name": "DHRS3", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ] } ] }, { "uniprot_ac": "O77769", "gene_name": "DHRS3", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "O77769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77769" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "O77769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77769" } ] } ] }, { "uniprot_ac": "P16116", "gene_name": "AKR1B1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.21", "activity": "L-arabinitol + NADP(+) = L-arabinose + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] } ] }, { "uniprot_ac": "P59837", "gene_name": "RDH12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "P59837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P59837" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P59837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P59837" } ] } ] }, { "uniprot_ac": "Q17QW3", "gene_name": "RDH14", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q17QW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW3" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q17QW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW3" } ] } ] }, { "uniprot_ac": "Q8HZT6", "gene_name": "RDH10", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q8HZT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZT6" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8HZT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZT6" } ] } ] }, { "uniprot_ac": "Q8SPU8", "gene_name": "DHRS4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + NADPH + H(+).", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] } ] }, { "uniprot_ac": "Q9N126", "gene_name": "RDH8", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q9N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N126" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q9N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N126" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" }, { "id": "SM00822", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00822" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ketoreductase", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 208, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.300", "ec_name": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "1.1.1.300", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300" }, { "id": "1.1.1.300", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.300" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUT0-1", "uniprot_ac": "A0AAF6YUT0", "uniprot_id": "A0AAF6YUT0_BOVIN", "mass": { "chemical_mass": 42668.0, "monoisotopic_mass": 42668.0 }, "refseq": {}, "gene_names": [ { "name": "THG1L", "type": "recommended", "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ] } ], "protein_names": [ { "name": "Probable tRNA(His) guanylyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.79", "type": "synonym", "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0/entry#names_and_taxonomy" } ] }, { "name": "tRNA-histidine guanylyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0#function" }, { "database": "UniProtKB", "id": "ARBA00058346", "url": "https://www.uniprot.org/uniprotkb/ARBA00058346#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THG1L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0", "locus": { "chromosome": "7", "start_pos": 69327120, "end_pos": 69320025, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010359", "url": "https://www.ensembl.org/id/ENSBTAG00000010359" } ] } } ], "crossref": [ { "id": "A0AAF6YUT0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12729", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12729", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12729:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12729:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04446", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04446", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14413", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "54564", "url": "https://www.rhea-db.org/rhea/54564", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCCRPRGHMATIKNSAKGRLEPSFQARKSITNYKERQARCWPPLWLERPRKDTGTSGAELSVPFPTLGEMWAAGALKVRDCLAATSVTLRRCLKLGATMAKSKFEYVRDFEADDTCLPHCWVVVRLDGRNFHRFAEKHSFIKPNDSRALHLMTKCAQTVMNELEDIVIAYGQSDEYSFVFKRKSNWFKRRASKFMTHVVSQFASSYVFYWRDYFEDQPLLYPPGFDGRVIVYPSNQTLKDYLSWRQADCHINNLYNTVFWALVQQSGLTPLQAQERLQGTLAADKNEILFSEFNINYNNEPLMYRKGTVLIWQKVEEITTKEVKLPAEMEGKKMAVTRTRTMVVPLHCNIIGDAFWKEHPEILDEDS", "length": 368, "header": "tr|A0AAF6YUT0-1|A0AAF6YUT0_BOVIN Isoform 1 of Probable tRNA(His) guanylyltransferase OS=Bos taurus OX=9913 GN=THG1L PE=3 SV=1 CANONICAL=A0AAF6YUT0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0/entry", "sequence": { "sequence": "MTCCRPRGHMATIKNSAKGRLEPSFQARKSITNYKERQARCWPPLWLERPRKDTGTSGAELSVPFPTLGEMWAAGALKVRDCLAATSVTLRRCLKLGATMAKSKFEYVRDFEADDTCLPHCWVVVRLDGRNFHRFAEKHSFIKPNDSRALHLMTKCAQTVMNELEDIVIAYGQSDEYSFVFKRKSNWFKRRASKFMTHVVSQFASSYVFYWRDYFEDQPLLYPPGFDGRVIVYPSNQTLKDYLSWRQADCHINNLYNTVFWALVQQSGLTPLQAQERLQGTLAADKNEILFSEFNINYNNEPLMYRKGTVLIWQKVEEITTKEVKLPAEMEGKKMAVTRTRTMVVPLHCNIIGDAFWKEHPEILDEDS", "length": 368, "header": "tr|A0AAF6YUT0-1|A0AAF6YUT0_BOVIN Isoform 1 of Probable tRNA(His) guanylyltransferase OS=Bos taurus OX=9913 GN=THG1L PE=3 SV=1 CANONICAL=A0AAF6YUT0-1" }, "locus": { "chromosome": "7", "start_pos": 69325826, "end_pos": 69320029, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013678.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013678.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013678.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013678.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "transferase complex", "id": "GO:1990234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990234", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "stress-induced mitochondrial fusion", "id": "GO:1990046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990046", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" }, { "name": "tRNA guanylyltransferase activity", "id": "GO:0008193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008193", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54564", "name": "", "equation": "a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUT0-1", "Q05B50-1" ], "evidence": [ { "id": "54564", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54564" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YUT0", "gene_name": "THG1L", "activity": [ { "ec_number": "2.7.7.79", "activity": "a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+).", "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ] }, { "ec_number": "2.7.7.79", "activity": "", "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" } ] } ] }, { "uniprot_ac": "Q05B50", "gene_name": "THG1L", "activity": [ { "ec_number": "2.7.7.79", "activity": "a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+).", "evidence": [ { "id": "Q05B50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B50" } ] }, { "ec_number": "2.7.7.79", "activity": "", "evidence": [ { "id": "Q05B50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B50" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" }, { "id": "PF14413", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14413" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thg1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 352, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YUT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUT0" }, { "id": "PF04446", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04446" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "tRNAHis guanylyltransferase catalytic", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 234, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.79", "ec_name": "a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+).", "evidence": [ { "id": "2.7.7.79", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.79" }, { "id": "2.7.7.79", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.79" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 236, "end_pos": 238 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUU2-1", "uniprot_ac": "A0AAF6YUU2", "uniprot_id": "A0AAF6YUU2_BOVIN", "mass": { "chemical_mass": 38291.0, "monoisotopic_mass": 38291.0 }, "refseq": { "ac": "XP_005215640", "name": "ER membrane protein complex subunit 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215640" }, "gene_names": [ { "name": "EMC2", "type": "recommended", "evidence": [ { "id": "A0AAF6YUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ] }, { "name": "EMC2", "type": "synonym", "evidence": [ { "id": "XP_005215640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215640" } ] }, { "name": "TTC35", "type": "synonym", "evidence": [ { "id": "XP_005215640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215640" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAF6YUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2/entry#names_and_taxonomy" } ] }, { "name": "ER membrane protein complex subunit 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005215640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215640" } ] } ], "function": [ { "annotation": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2#function" }, { "database": "UniProtKB", "id": "RU367091", "url": "https://www.uniprot.org/uniprotkb/RU367091#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2", "locus": { "chromosome": "14", "start_pos": 55973618, "end_pos": 56023868, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010006", "url": "https://www.ensembl.org/id/ENSBTAG00000010006" } ] } } ], "crossref": [ { "id": "A0AAF6YUU2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "616813", "url": "https://www.ncbi.nlm.nih.gov/gene/616813", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12760", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12760", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22890", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22890", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215640", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215640", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTGVVIRHCLVSCRVTTSPRPLTQPPPGSEKMAKVSELYDVTWEEMRDKMRKWREENSRNSEQIVEVGEELISEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPYNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINKAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 329, "header": "tr|A0AAF6YUU2-1|A0AAF6YUU2_BOVIN Isoform 1 of ER membrane protein complex subunit 2 OS=Bos taurus OX=9913 GN=EMC2 PE=3 SV=1 CANONICAL=A0AAF6YUU2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2/entry", "sequence": { "sequence": "MRTGVVIRHCLVSCRVTTSPRPLTQPPPGSEKMAKVSELYDVTWEEMRDKMRKWREENSRNSEQIVEVGEELISEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPYNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINKAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 329, "header": "tr|A0AAF6YUU2-1|A0AAF6YUU2_BOVIN Isoform 1 of ER membrane protein complex subunit 2 OS=Bos taurus OX=9913 GN=EMC2 PE=3 SV=1 CANONICAL=A0AAF6YUU2-1" }, "locus": { "chromosome": "14", "start_pos": 56023837, "end_pos": 55973956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013197.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013197.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013197.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013197.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ], "pmid": "" }, { "name": "extrinsic component of endoplasmic reticulum membrane", "id": "GO:0042406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042406", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU2" }, { "id": "PF22890", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22890" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EMC2 TPR-like", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 231, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUU7-1", "uniprot_ac": "A0AAF6YUU7", "uniprot_id": "A0AAF6YUU7_BOVIN", "mass": { "chemical_mass": 48130.0, "monoisotopic_mass": 48130.0 }, "refseq": {}, "gene_names": [ { "name": "NMRAL1", "type": "recommended", "evidence": [ { "id": "A0AAF6YUU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7" } ] } ], "protein_names": [ { "name": "NmrA-like family domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6YUU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7#function" }, { "database": "UniProtKB", "id": "ARBA00060053", "url": "https://www.uniprot.org/uniprotkb/ARBA00060053#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NMRAL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7", "locus": { "chromosome": "25", "start_pos": 3608229, "end_pos": 3615865, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010015", "url": "https://www.ensembl.org/id/ENSBTAG00000010015" } ] } } ], "crossref": [ { "id": "A0AAF6YUU7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05251", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05251", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR008030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42748", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42748", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42748:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42748:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METSAYHHETDIPEQLRAGGSRPSAEFARVGTNHLCLRRGVACPLRAVRARTARIRKQPSLGSLHAGCLGKHGFARLPLELRARVGATCRVASPLCRGLGCSLTGPQFPERFTPRPPLGGTAGLEGPGKGCGLLGTTPSAPAHMADKKLVVVFGATGAQGGSVARTLLEDGTFRVRVVTRDPGQRAAKQLRLQGAEVVQGDQDDEASMELALSGAHATFIVTNYWENCSQEQEVKQGKLLADLAKRLGLRYVVYSGLENIKKLTAGRLTVGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSYFLPQKAPDGRSYLLSLPMGDVPIDGMSVADLGPVVLSLLKTPEEYVGRNIGLSTCRHTVEEYAALLTKHTGKAVRDAKTSPEDYEKLGFPGAQDLANMFRFYALKPDRNIELTLKLNPKARRLDQWLEQHKEDFAGL", "length": 442, "header": "tr|A0AAF6YUU7-1|A0AAF6YUU7_BOVIN Isoform 1 of NmrA-like family domain-containing protein 1 OS=Bos taurus OX=9913 GN=NMRAL1 PE=3 SV=1 CANONICAL=A0AAF6YUU7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7/entry", "sequence": { "sequence": "METSAYHHETDIPEQLRAGGSRPSAEFARVGTNHLCLRRGVACPLRAVRARTARIRKQPSLGSLHAGCLGKHGFARLPLELRARVGATCRVASPLCRGLGCSLTGPQFPERFTPRPPLGGTAGLEGPGKGCGLLGTTPSAPAHMADKKLVVVFGATGAQGGSVARTLLEDGTFRVRVVTRDPGQRAAKQLRLQGAEVVQGDQDDEASMELALSGAHATFIVTNYWENCSQEQEVKQGKLLADLAKRLGLRYVVYSGLENIKKLTAGRLTVGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSYFLPQKAPDGRSYLLSLPMGDVPIDGMSVADLGPVVLSLLKTPEEYVGRNIGLSTCRHTVEEYAALLTKHTGKAVRDAKTSPEDYEKLGFPGAQDLANMFRFYALKPDRNIELTLKLNPKARRLDQWLEQHKEDFAGL", "length": 442, "header": "tr|A0AAF6YUU7-1|A0AAF6YUU7_BOVIN Isoform 1 of NmrA-like family domain-containing protein 1 OS=Bos taurus OX=9913 GN=NMRAL1 PE=3 SV=1 CANONICAL=A0AAF6YUU7-1" }, "locus": { "chromosome": "25", "start_pos": 3615750, "end_pos": 3608351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013208.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013208.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013208.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013208.4" } ] } }, { "isoform_ac": "A0AAF7A9R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9R4/entry", "sequence": { "sequence": "VRPDLRKFGLRRLRAGGSRPSAEFARVGTNHLCLRRGVACPLRAVRARTARIRKQPSLGSLHAGCLGKHGFARLPLELRARVGATCRVASPLCRGLGCSLTGPQFPERFTPRPPLGDFSGPHLPLPLTWRTRSWWWCLEPQGKLLADLAKRLGLRYVVYSGLENIKKLTAGRLTVGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSYFLPQKAPDGRSYLLSLPMGDVPIDGMSVADLGPVVLSLLKTPEEYVGRNIGLSTCRHTVEEYAALLTKHTGKAVRDAKTSPEDYEKLGFPGAQDLANMFRFYALKPDRNIELTLKLNPKARRLDQWLEQHKEDFAGL", "length": 347, "header": "tr|A0AAF7A9R4-1|A0AAF7A9R4_BOVIN Computationally mapped isoform of NmrA-like family domain-containing protein 1 OS=Bos taurus OX=9913 GN=NMRAL1 PE=3 SV=1 CANONICAL=A0AAF6YUU7-1" }, "locus": { "chromosome": "25", "start_pos": 3614399, "end_pos": 3608351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069988.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069988.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065595.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065595.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUU7" }, { "id": "PF05368", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05368" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NmrA-like", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 418, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YUZ1-1", "uniprot_ac": "A0AAF6YUZ1", "uniprot_id": "A0AAF6YUZ1_BOVIN", "mass": { "chemical_mass": 34793.0, "monoisotopic_mass": 34793.0 }, "refseq": {}, "gene_names": [ { "name": "NUDT21", "type": "recommended", "evidence": [ { "id": "A0AAF6YUZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ] } ], "protein_names": [ { "name": "Cleavage and polyadenylation specificity factor subunit 5", "type": "recommended", "evidence": [ { "id": "A0AAF6YUZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1/entry#names_and_taxonomy" } ] }, { "name": "Nucleoside diphosphate-linked moiety X motif 21", "type": "synonym", "evidence": [ { "id": "A0AAF6YUZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1", "locus": { "chromosome": "18", "start_pos": 24199512, "end_pos": 24184580, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010207", "url": "https://www.ensembl.org/id/ENSBTAG00000010207" } ] } } ], "crossref": [ { "id": "A0AAF6YUZ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YUZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18871", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18871", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016706", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016706", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13047", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13047", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13869", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13869", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAPDTAAIPAVIGSFGDRTPPFYFLPPEAPGALPASVCLLRRSLVNGRRRLLTGTQTTAAHTGKVSLPPVFRSLLVPELSSMSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN", "length": 309, "header": "tr|A0AAF6YUZ1-1|A0AAF6YUZ1_BOVIN Isoform 1 of Cleavage and polyadenylation specificity factor subunit 5 OS=Bos taurus OX=9913 GN=NUDT21 PE=3 SV=1 CANONICAL=A0AAF6YUZ1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YUZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1/entry", "sequence": { "sequence": "MGAPDTAAIPAVIGSFGDRTPPFYFLPPEAPGALPASVCLLRRSLVNGRRRLLTGTQTTAAHTGKVSLPPVFRSLLVPELSSMSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN", "length": 309, "header": "tr|A0AAF6YUZ1-1|A0AAF6YUZ1_BOVIN Isoform 1 of Cleavage and polyadenylation specificity factor subunit 5 OS=Bos taurus OX=9913 GN=NUDT21 PE=3 SV=1 CANONICAL=A0AAF6YUZ1-1" }, "locus": { "chromosome": "18", "start_pos": 24199253, "end_pos": 24184779, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013467.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013467.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013467.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013467.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "mRNA 3'-UTR AU-rich region binding", "id": "GO:0035925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035925", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "paraspeckles", "id": "GO:0042382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042382", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "post-transcriptional regulation of gene expression", "id": "GO:0010608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010608", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "protein heterotetramerization", "id": "GO:0051290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051290", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "positive regulation of stem cell differentiation", "id": "GO:2000738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000738", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "mRNA alternative polyadenylation", "id": "GO:0110104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110104", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "positive regulation of pro-B cell differentiation", "id": "GO:2000975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000975", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" }, { "name": "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "id": "GO:0180010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180010", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YUZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUZ1" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 158, "end_pos": 283, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YV42-1", "uniprot_ac": "A0AAF6YV42", "uniprot_id": "A0AAF6YV42_BOVIN", "mass": { "chemical_mass": 31019.0, "monoisotopic_mass": 31019.0 }, "refseq": {}, "gene_names": [ { "name": "SPATA46", "type": "recommended", "evidence": [ { "id": "A0AAF6YV42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42" } ] } ], "protein_names": [ { "name": "Spermatosis associated 46", "type": "synonym", "evidence": [ { "id": "A0AAF6YV42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YV42", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA46", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42", "locus": { "chromosome": "3", "start_pos": 7119975, "end_pos": 7112701, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010174", "url": "https://www.ensembl.org/id/ENSBTAG00000010174" } ] } } ], "crossref": [ { "id": "A0AAF6YV42", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YV42", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33517:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33517:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17734", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17734", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YV42", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YV42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPALGMFIVQTTQPASWEQLYVTSVPFGSQNMENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPDCILGDAPNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRPGPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYKEQKARPGDRLSLGSGQAFR", "length": 279, "header": "tr|A0AAF6YV42-1|A0AAF6YV42_BOVIN Isoform 1 of Spermatosis associated 46 OS=Bos taurus OX=9913 GN=SPATA46 PE=4 SV=1 CANONICAL=A0AAF6YV42-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YV42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42/entry", "sequence": { "sequence": "MSPALGMFIVQTTQPASWEQLYVTSVPFGSQNMENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPDCILGDAPNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRPGPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYKEQKARPGDRLSLGSGQAFR", "length": 279, "header": "tr|A0AAF6YV42-1|A0AAF6YV42_BOVIN Isoform 1 of Spermatosis associated 46 OS=Bos taurus OX=9913 GN=SPATA46 PE=4 SV=1 CANONICAL=A0AAF6YV42-1" }, "locus": { "chromosome": "3", "start_pos": 7119857, "end_pos": 7117185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013422.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013422.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013422.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013422.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YV42", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42" } ], "pmid": "" }, { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YV42", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YV42", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YV42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 35, "end_pos": 37 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVA9-1", "uniprot_ac": "A0AAF6YVA9", "uniprot_id": "A0AAF6YVA9_BOVIN", "mass": { "chemical_mass": 15178.0, "monoisotopic_mass": 15178.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "CUB domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YVA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVA9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9", "locus": {} } ], "crossref": [ { "id": "A0AAF6YVA9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVA9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46908", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46908", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46908:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46908:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YVA9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLSSVIPWALLLSTATVDSMDWLPRNTNCGGILKEESGVIATYYGPKTNCVWTIQMPPEYHVRVSIQYLQLNCNKESLEIIDGLPGSPVLGKICEGSLMDYRSSGSIMTVKYIREPEHPASFYEVLYFQDPQGR", "length": 135, "header": "tr|A0AAF6YVA9-1|A0AAF6YVA9_BOVIN Isoform 1 of CUB domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YVA9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YVA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9/entry", "sequence": { "sequence": "MKLSSVIPWALLLSTATVDSMDWLPRNTNCGGILKEESGVIATYYGPKTNCVWTIQMPPEYHVRVSIQYLQLNCNKESLEIIDGLPGSPVLGKICEGSLMDYRSSGSIMTVKYIREPEHPASFYEVLYFQDPQGR", "length": 135, "header": "tr|A0AAF6YVA9-1|A0AAF6YVA9_BOVIN Isoform 1 of CUB domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6YVA9-1" }, "locus": { "chromosome": "26", "start_pos": 42619540, "end_pos": 42550450, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014297.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014297.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014297.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014297.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVA9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVA9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YVA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVA9" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 131, "start_aa": "Cys", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVB0-1", "uniprot_ac": "A0AAF6YVB0", "uniprot_id": "A0AAF6YVB0_BOVIN", "mass": { "chemical_mass": 85384.0, "monoisotopic_mass": 85384.0 }, "refseq": {}, "gene_names": [ { "name": "MCM3", "type": "recommended", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ], "protein_names": [ { "name": "DNA replication licensing factor MCM3", "type": "recommended", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.12", "type": "synonym", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0#function" }, { "database": "UniProtKB", "id": "ARBA00054613", "url": "https://www.uniprot.org/uniprotkb/ARBA00054613#function" } ] }, { "annotation": "Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0#function" }, { "database": "UniProtKB", "id": "RU368061", "url": "https://www.uniprot.org/uniprotkb/RU368061#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCM3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0", "locus": { "chromosome": "23", "start_pos": 24694546, "end_pos": 24711930, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010721", "url": "https://www.ensembl.org/id/ENSBTAG00000010721" } ] } } ], "crossref": [ { "id": "A0AAF6YVB0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17754", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17754", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11630:SF106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11630:SF106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14551", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14551", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLSNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTSLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQIITIQEMPEKAPAGQLPRSVDVILDDDLVDRVKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDVQPSFSAEDIAKIKKFSKTRSKDIFDQLARSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSPDDQQDTQIYEKHDNLLHGIKKKKEKMVSAAFMRKYIHVAKIIKPVLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESDAEDEVEKSQEDQEQKTKRQRFVQAWAQHSIWTTGVLGGGSVPRTPRRGTPMTPMTSPTRRRKCLRCTLQRQQTHRRPRSPRRWS", "length": 757, "header": "tr|A0AAF6YVB0-1|A0AAF6YVB0_BOVIN Isoform 1 of DNA replication licensing factor MCM3 OS=Bos taurus OX=9913 GN=MCM3 PE=3 SV=1 CANONICAL=A0AAF6YVB0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YVB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0/entry", "sequence": { "sequence": "MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLSNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTSLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQIITIQEMPEKAPAGQLPRSVDVILDDDLVDRVKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDVQPSFSAEDIAKIKKFSKTRSKDIFDQLARSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSPDDQQDTQIYEKHDNLLHGIKKKKEKMVSAAFMRKYIHVAKIIKPVLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESDAEDEVEKSQEDQEQKTKRQRFVQAWAQHSIWTTGVLGGGSVPRTPRRGTPMTPMTSPTRRRKCLRCTLQRQQTHRRPRSPRRWS", "length": 757, "header": "tr|A0AAF6YVB0-1|A0AAF6YVB0_BOVIN Isoform 1 of DNA replication licensing factor MCM3 OS=Bos taurus OX=9913 GN=MCM3 PE=3 SV=1 CANONICAL=A0AAF6YVB0-1" }, "locus": { "chromosome": "23", "start_pos": 24711890, "end_pos": 24696420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014194.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014194.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014194.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014194.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" }, { "name": "MCM complex", "id": "GO:0042555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042555", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 533, "end_pos": 535, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" }, { "id": "PS50051", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50051" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MCM C-terminal AAA(+) ATPase", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 501, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" }, { "id": "PRU01410", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01410" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Walker A", "eco_id": "ECO_0000256", "start_pos": 362, "end_pos": 369, "start_aa": "Ala", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" }, { "id": "PRU01410", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01410" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Walker B", "eco_id": "ECO_0000256", "start_pos": 426, "end_pos": 429, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.4.12", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 331, "end_pos": 333 }, { "start_pos": 533, "end_pos": 535 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVB5-1", "uniprot_ac": "A0AAF6YVB5", "uniprot_id": "A0AAF6YVB5_BOVIN", "mass": { "chemical_mass": 47117.0, "monoisotopic_mass": 47117.0 }, "refseq": { "ac": "XP_005205085", "name": "selenocysteine lyase isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205085" }, "gene_names": [ { "name": "SCLY", "type": "recommended", "evidence": [ { "id": "A0AAF6YVB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" } ] }, { "name": "SCLY", "type": "synonym", "evidence": [ { "id": "XP_005205085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205085" } ] } ], "protein_names": [ { "name": "Selenocysteine lyase", "type": "recommended", "evidence": [ { "id": "A0AAF6YVB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5/entry#names_and_taxonomy" } ] }, { "name": "4.4.1.16", "type": "synonym", "evidence": [ { "id": "A0AAF6YVB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5/entry#names_and_taxonomy" } ] }, { "name": "selenocysteine lyase isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005205085", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205085" } ] } ], "function": [ { "annotation": "Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5#function" }, { "database": "UniProtKB", "id": "ARBA00037407", "url": "https://www.uniprot.org/uniprotkb/ARBA00037407#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCLY", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5", "locus": { "chromosome": "3", "start_pos": 117440408, "end_pos": 117410368, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017826", "url": "https://www.ensembl.org/id/ENSBTAG00000017826" } ] } } ], "crossref": [ { "id": "A0AAF6YVB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "790815", "url": "https://www.ncbi.nlm.nih.gov/gene/790815", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11601", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11601", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11601:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11601:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005205085", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205085", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAAGARNRDARSRAEKSPPERKVYMDYNATTPLEPEVIEAMTEAMREAWGNPSSSYPAGRKAKEIINTARENLAKMIGGQPQDVIFTSGGTESNNLVIQSVVKHFHKVHAANGDTGGHPNPVDGALPHIITCTVEHDSIRLPLEHLREERVAEVTFVPVSKVNGQVEAEDILAAVRPATCLVTIMLANNETGVIMPVPEISRRVRALNQQRVAGGLPGVLVHTDAAQALGKQRVDVRDLGVDFLTIVGHKFYGPRIGALYVRGLGEHTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVAENGEAYEAHMRGVRDYLEERLAAEFGERIHLNSQFPGAERLPNTCNFSIRGPQLQGRAVLAQCRTLLASVGAACHSDLGDRPSPVLLSCGVPVDVARNAIRLSVGRSSTRAEVDLVVQDLKQAVARLEGQA", "length": 436, "header": "tr|A0AAF6YVB5-1|A0AAF6YVB5_BOVIN Isoform 1 of Selenocysteine lyase OS=Bos taurus OX=9913 GN=SCLY PE=3 SV=1 CANONICAL=A0AAF6YVB5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YVB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5/entry", "sequence": { "sequence": "MEAAGARNRDARSRAEKSPPERKVYMDYNATTPLEPEVIEAMTEAMREAWGNPSSSYPAGRKAKEIINTARENLAKMIGGQPQDVIFTSGGTESNNLVIQSVVKHFHKVHAANGDTGGHPNPVDGALPHIITCTVEHDSIRLPLEHLREERVAEVTFVPVSKVNGQVEAEDILAAVRPATCLVTIMLANNETGVIMPVPEISRRVRALNQQRVAGGLPGVLVHTDAAQALGKQRVDVRDLGVDFLTIVGHKFYGPRIGALYVRGLGEHTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVAENGEAYEAHMRGVRDYLEERLAAEFGERIHLNSQFPGAERLPNTCNFSIRGPQLQGRAVLAQCRTLLASVGAACHSDLGDRPSPVLLSCGVPVDVARNAIRLSVGRSSTRAEVDLVVQDLKQAVARLEGQA", "length": 436, "header": "tr|A0AAF6YVB5-1|A0AAF6YVB5_BOVIN Isoform 1 of Selenocysteine lyase OS=Bos taurus OX=9913 GN=SCLY PE=3 SV=1 CANONICAL=A0AAF6YVB5-1" }, "locus": { "chromosome": "3", "start_pos": 117440214, "end_pos": 117410559, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013719.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013719.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013719.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013719.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" } ], "pmid": "" }, { "name": "selenocysteine lyase activity", "id": "GO:0009000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009000", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YVB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB5" }, { "id": "PF00266", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00266" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminotransferase class V", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 420, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.4.1.16", "ec_name": "L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+).", "evidence": [ { "id": "4.4.1.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.16" }, { "id": "4.4.1.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.16" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 351, "end_pos": 353 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVJ7-1", "uniprot_ac": "A0AAF6YVJ7", "uniprot_id": "A0AAF6YVJ7_BOVIN", "mass": { "chemical_mass": 17164.0, "monoisotopic_mass": 17164.0 }, "refseq": {}, "gene_names": [ { "name": "TRAPPC2", "type": "recommended", "evidence": [ { "id": "A0AAF6YVJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAF6YVJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi.", "evidence": [ { "database": "UniProtKB", "id": "A0ABI0P3H4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3H4#function" }, { "database": "UniProtKB", "id": "ARBA00054979", "url": "https://www.uniprot.org/uniprotkb/ARBA00054979#function" }, { "database": "UniProtKB", "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7", "locus": { "chromosome": "X", "start_pos": 129808212, "end_pos": 129796070, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010922", "url": "https://www.ensembl.org/id/ENSBTAG00000010922" } ] } } ], "crossref": [ { "id": "A0AAF6YVJ7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVJ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14825", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14825", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3H4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3H4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3H4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTADYTLIISHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 146, "header": "tr|A0AAF6YVJ7-1|A0AAF6YVJ7_BOVIN Isoform 1 of Trafficking protein particle complex subunit 2 OS=Bos taurus OX=9913 GN=TRAPPC2 PE=3 SV=1 CANONICAL=A0AAF6YVJ7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YVJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7/entry", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTADYTLIISHMRFIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS", "length": 146, "header": "tr|A0AAF6YVJ7-1|A0AAF6YVJ7_BOVIN Isoform 1 of Trafficking protein particle complex subunit 2 OS=Bos taurus OX=9913 GN=TRAPPC2 PE=3 SV=1 CANONICAL=A0AAF6YVJ7-1" }, "locus": { "chromosome": "X", "start_pos": 129807982, "end_pos": 129803239, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014509.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014509.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014509.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014509.5" } ] } }, { "isoform_ac": "A0ABI0P3H4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3H4/entry", "sequence": { "sequence": "MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDVRQEDGIKNFFTDVYDLYIKVYVLY", "length": 113, "header": "tr|A0ABI0P3H4-1|A0ABI0P3H4_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2 OS=Bos taurus OX=9913 GN=TRAPPC2 PE=3 SV=1 CANONICAL=A0AAF6YVJ7-1" }, "locus": { "chromosome": "X", "start_pos": 129806672, "end_pos": 129803239, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141200.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141200.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105282.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105282.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVJ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVN5-1", "uniprot_ac": "A0AAF6YVN5", "uniprot_id": "A0AAF6YVN5_BOVIN", "mass": { "chemical_mass": 58014.0, "monoisotopic_mass": 58014.0 }, "refseq": {}, "gene_names": [ { "name": "ANGPTL1", "type": "recommended", "evidence": [ { "id": "A0AAF6YVN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5" } ] } ], "protein_names": [ { "name": "Angiopoietin like 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YVN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANGPTL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5", "locus": { "chromosome": "16", "start_pos": 60222330, "end_pos": 60246517, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010719", "url": "https://www.ensembl.org/id/ENSBTAG00000010719" } ] } } ], "crossref": [ { "id": "A0AAF6YVN5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YVN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKDSIQPHFKMKAFIWTLSVLFFLLMGIGHGRGRQFKIKKITQRRYPRATDGKEDAKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSKQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDPHVSPPLVQVVPQHIPNSHQYTPGLLGGNEIQRDPGYPRDLMPPPDLVTSPTKSPLKIPPVTFINEGPYKDCQHAKDAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYLLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKYQDGIFWAEYRGGSYSLRAVQMLIKPID", "length": 502, "header": "tr|A0AAF6YVN5-1|A0AAF6YVN5_BOVIN Isoform 1 of Angiopoietin like 1 OS=Bos taurus OX=9913 GN=ANGPTL1 PE=4 SV=1 CANONICAL=A0AAF6YVN5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YVN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5/entry", "sequence": { "sequence": "MQKDSIQPHFKMKAFIWTLSVLFFLLMGIGHGRGRQFKIKKITQRRYPRATDGKEDAKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSKQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDPHVSPPLVQVVPQHIPNSHQYTPGLLGGNEIQRDPGYPRDLMPPPDLVTSPTKSPLKIPPVTFINEGPYKDCQHAKDAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYLLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKYQDGIFWAEYRGGSYSLRAVQMLIKPID", "length": 502, "header": "tr|A0AAF6YVN5-1|A0AAF6YVN5_BOVIN Isoform 1 of Angiopoietin like 1 OS=Bos taurus OX=9913 GN=ANGPTL1 PE=4 SV=1 CANONICAL=A0AAF6YVN5-1" }, "locus": { "chromosome": "16", "start_pos": 60246235, "end_pos": 60223092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014193.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014193.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014193.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014193.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YVN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVN5" }, { "id": "PS51406", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000259", "start_pos": 282, "end_pos": 502, "start_aa": "Phe", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 199, "end_pos": 201 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YVW8-1", "uniprot_ac": "A0AAF6YVW8", "uniprot_id": "A0AAF6YVW8_BOVIN", "mass": { "chemical_mass": 48536.0, "monoisotopic_mass": 48536.0 }, "refseq": {}, "gene_names": [ { "name": "TUBB4A", "type": "recommended", "evidence": [ { "id": "A0AAF6YVW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ] } ], "protein_names": [ { "name": "Tubulin beta chain", "type": "recommended", "evidence": [ { "id": "A0AAF6YVW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8#function" }, { "database": "UniProtKB", "id": "RU000352", "url": "https://www.uniprot.org/uniprotkb/RU000352#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUBB4A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8", "locus": { "chromosome": "7", "start_pos": 17988430, "end_pos": 17981998, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021013", "url": "https://www.ensembl.org/id/ENSBTAG00000021013" } ] } } ], "crossref": [ { "id": "A0AAF6YVW8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YVW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02187", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02187", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013838", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013838", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEVA", "length": 435, "header": "tr|A0AAF6YVW8-1|A0AAF6YVW8_BOVIN Isoform 1 of Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB4A PE=3 SV=1 CANONICAL=A0AAF6YVW8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YVW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8/entry", "sequence": { "sequence": "MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEVA", "length": 435, "header": "tr|A0AAF6YVW8-1|A0AAF6YVW8_BOVIN Isoform 1 of Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB4A PE=3 SV=1 CANONICAL=A0AAF6YVW8-1" }, "locus": { "chromosome": "7", "start_pos": 17987426, "end_pos": 17982083, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014560.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014560.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014560.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014560.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "sperm end piece", "id": "GO:0097229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097229", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "internode region of axon", "id": "GO:0033269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033269", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "myelin sheath", "id": "GO:0043209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043209", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule-based process", "id": "GO:0007017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007017", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" }, { "name": "negative regulation of microtubule polymerization", "id": "GO:0031115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031115", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YVW8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YVW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" }, { "id": "SM00865", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubulin/FtsZ 2-layer sandwich", "eco_id": "ECO_0000259", "start_pos": 246, "end_pos": 383, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YVW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVW8" }, { "id": "SM00864", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00864" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubulin/FtsZ GTPase", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 244, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 370, "end_pos": 372 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YW04-1", "uniprot_ac": "A0AAF6YW04", "uniprot_id": "A0AAF6YW04_BOVIN", "mass": { "chemical_mass": 31827.0, "monoisotopic_mass": 31827.0 }, "refseq": {}, "gene_names": [ { "name": "SDC1", "type": "recommended", "evidence": [ { "id": "A0AAF6YW04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ] } ], "protein_names": [ { "name": "Syndecan", "type": "recommended", "evidence": [ { "id": "A0AAF6YW04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04#function" }, { "database": "UniProtKB", "id": "ARBA00045247", "url": "https://www.uniprot.org/uniprotkb/ARBA00045247#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDC1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04", "locus": { "chromosome": "11", "start_pos": 78653583, "end_pos": 78647246, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011154", "url": "https://www.ensembl.org/id/ENSBTAG00000011154" } ] } } ], "crossref": [ { "id": "A0AAF6YW04", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YW04", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10915", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10915", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10915:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10915:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01034", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01034", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERHHLGSPPDLQGCWVKHSVAVNMPPEDQDGSGDDSDNFSGSGAGALPDITSSHTPSTWKDLGPVTTTATAPEPTSPDAIAASTTILPTGEQPEGGRAVLLAEVEPGLTAQKEATHPPSETTLHPTTHSVSTARATMAPGPATSHPHRDVQPDHHETSAPTGRGRMEPHRPHVEEGGPPATEKAAEEDPSTQIPVGEGSGEQDFTFDLSGENAAGAAGEPGSRNGAPEDPEATGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA", "length": 307, "header": "tr|A0AAF6YW04-1|A0AAF6YW04_BOVIN Isoform 1 of Syndecan OS=Bos taurus OX=9913 GN=SDC1 PE=3 SV=1 CANONICAL=A0AAF6YW04-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YW04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04/entry", "sequence": { "sequence": "MERHHLGSPPDLQGCWVKHSVAVNMPPEDQDGSGDDSDNFSGSGAGALPDITSSHTPSTWKDLGPVTTTATAPEPTSPDAIAASTTILPTGEQPEGGRAVLLAEVEPGLTAQKEATHPPSETTLHPTTHSVSTARATMAPGPATSHPHRDVQPDHHETSAPTGRGRMEPHRPHVEEGGPPATEKAAEEDPSTQIPVGEGSGEQDFTFDLSGENAAGAAGEPGSRNGAPEDPEATGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA", "length": 307, "header": "tr|A0AAF6YW04-1|A0AAF6YW04_BOVIN Isoform 1 of Syndecan OS=Bos taurus OX=9913 GN=SDC1 PE=3 SV=1 CANONICAL=A0AAF6YW04-1" }, "locus": { "chromosome": "11", "start_pos": 78652306, "end_pos": 78647309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014810.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014810.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014810.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014810.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" }, { "name": "cargo receptor activity", "id": "GO:0038024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038024", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" }, { "name": "positive regulation of exosomal secretion", "id": "GO:1903543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903543", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" }, { "name": "positive regulation of extracellular exosome assembly", "id": "GO:1903553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903553", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" }, { "name": "myoblast development", "id": "GO:0048627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" }, { "name": "striated muscle cell development", "id": "GO:0055002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055002", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW04", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YW04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW04" }, { "id": "SM00294", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00294" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Neurexin/syndecan/glycophorin C", "eco_id": "ECO_0000259", "start_pos": 272, "end_pos": 290, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 39, "end_pos": 41 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YW16-1", "uniprot_ac": "A0AAF6YW16", "uniprot_id": "A0AAF6YW16_BOVIN", "mass": { "chemical_mass": 38144.0, "monoisotopic_mass": 38144.0 }, "refseq": {}, "gene_names": [ { "name": "CREB3", "type": "recommended", "evidence": [ { "id": "A0AAF6YW16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ] } ], "protein_names": [ { "name": "cAMP responsive element binding protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6YW16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CREB3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16", "locus": { "chromosome": "8", "start_pos": 59908033, "end_pos": 59901572, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011429", "url": "https://www.ensembl.org/id/ENSBTAG00000011429" } ] } } ], "crossref": [ { "id": "A0AAF6YW16", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YW16", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14689", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14689", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45996", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45996", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45996:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45996:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHMELALDPGDHDLLGFLLEESGGLGAAPDEALTSPPDWELPLSESLSDWDVEDFLSCLPSPPAVLNVFSNSDPCLVQHDHTYSLSQEHVSIDLDNESYEKERAQMTPLRVEEPADQEIARLILTEEEKRLLEKEGLTLPGMLPLTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGGLESRVLKYTAQNLELQNKVQLLEEQNLSLLDQLRRLQAMVIQTANKASSSSTCVLVLLFSFCLLLVPAMYSSDTRGSLPAEHRVLSRQLRALPSEDPPQLEPPALQSEQPIIGFLAPAKDGRKLILGLLCPTQSSHLDHHSHGRQPQSSATPSRPKEGSRY", "length": 341, "header": "tr|A0AAF6YW16-1|A0AAF6YW16_BOVIN Isoform 1 of cAMP responsive element binding protein 3 OS=Bos taurus OX=9913 GN=CREB3 PE=3 SV=1 CANONICAL=A0AAF6YW16-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YW16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16/entry", "sequence": { "sequence": "MSHMELALDPGDHDLLGFLLEESGGLGAAPDEALTSPPDWELPLSESLSDWDVEDFLSCLPSPPAVLNVFSNSDPCLVQHDHTYSLSQEHVSIDLDNESYEKERAQMTPLRVEEPADQEIARLILTEEEKRLLEKEGLTLPGMLPLTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGGLESRVLKYTAQNLELQNKVQLLEEQNLSLLDQLRRLQAMVIQTANKASSSSTCVLVLLFSFCLLLVPAMYSSDTRGSLPAEHRVLSRQLRALPSEDPPQLEPPALQSEQPIIGFLAPAKDGRKLILGLLCPTQSSHLDHHSHGRQPQSSATPSRPKEGSRY", "length": 341, "header": "tr|A0AAF6YW16-1|A0AAF6YW16_BOVIN Isoform 1 of cAMP responsive element binding protein 3 OS=Bos taurus OX=9913 GN=CREB3 PE=3 SV=1 CANONICAL=A0AAF6YW16-1" }, "locus": { "chromosome": "8", "start_pos": 59907533, "end_pos": 59901714, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015193.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015193.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015193.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015193.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 331, "start_aa": "Thr", "end_pos": 331, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr331", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "positive regulation of monocyte chemotaxis", "id": "GO:0090026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "id": "GO:1902236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902236", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" }, { "name": "transcription coregulator binding", "id": "GO:0001221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001221", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YW16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW16" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 153, "end_pos": 216, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 331 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YW51-1", "uniprot_ac": "A0AAF6YW51", "uniprot_id": "A0AAF6YW51_BOVIN", "mass": { "chemical_mass": 20701.0, "monoisotopic_mass": 20701.0 }, "refseq": {}, "gene_names": [ { "name": "PFN2", "type": "recommended", "evidence": [ { "id": "A0AAF6YW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ] } ], "protein_names": [ { "name": "Profilin", "type": "recommended", "evidence": [ { "id": "A0AAF6YW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51#function" }, { "database": "UniProtKB", "id": "ARBA00025549", "url": "https://www.uniprot.org/uniprotkb/ARBA00025549#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51", "locus": { "chromosome": "1", "start_pos": 118219790, "end_pos": 118213388, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011150", "url": "https://www.ensembl.org/id/ENSBTAG00000011150" } ] } } ], "crossref": [ { "id": "A0AAF6YW51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YW51", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00148", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00148", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13936", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13936", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13936:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13936:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00235", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00235", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPVEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRYPNITIWSVSSLFFIGPTFICSLSFYMKLHYCGLGCLVMNFSHMYSVPYYC", "length": 188, "header": "tr|A0AAF6YW51-1|A0AAF6YW51_BOVIN Isoform 1 of Profilin OS=Bos taurus OX=9913 GN=PFN2 PE=3 SV=1 CANONICAL=A0AAF6YW51-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YW51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51/entry", "sequence": { "sequence": "MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPVEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRYPNITIWSVSSLFFIGPTFICSLSFYMKLHYCGLGCLVMNFSHMYSVPYYC", "length": 188, "header": "tr|A0AAF6YW51-1|A0AAF6YW51_BOVIN Isoform 1 of Profilin OS=Bos taurus OX=9913 GN=PFN2 PE=3 SV=1 CANONICAL=A0AAF6YW51-1" }, "locus": { "chromosome": "1", "start_pos": 118219787, "end_pos": 118213412, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014805.8", "url": "https://www.ensembl.org/id/ENSBTAT00000014805.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014805.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014805.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "negative regulation of epithelial cell migration", "id": "GO:0010633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010633", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "modification of postsynaptic actin cytoskeleton", "id": "GO:0098885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098885", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "negative regulation of ruffle assembly", "id": "GO:1900028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900028", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "presynaptic actin cytoskeleton organization", "id": "GO:0099140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099140", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "presynaptic modulation of chemical synaptic transmission", "id": "GO:0099171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099171", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW51", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 177, "end_pos": 179 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YW66-1", "uniprot_ac": "A0AAF6YW66", "uniprot_id": "A0AAF6YW66_BOVIN", "mass": { "chemical_mass": 22832.0, "monoisotopic_mass": 22832.0 }, "refseq": {}, "gene_names": [ { "name": "MED22", "type": "recommended", "evidence": [ { "id": "A0AAF6YW66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 22", "type": "recommended", "evidence": [ { "id": "A0AAF6YW66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 22", "type": "synonym", "evidence": [ { "id": "A0AAF6YW66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66/entry#names_and_taxonomy" } ] }, { "name": "Surfeit locus protein 5", "type": "synonym", "evidence": [ { "id": "A0AAF6YW66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66#function" }, { "database": "UniProtKB", "id": "ARBA00025687", "url": "https://www.uniprot.org/uniprotkb/ARBA00025687#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66", "locus": { "chromosome": "11", "start_pos": 104249113, "end_pos": 104255141, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011556", "url": "https://www.ensembl.org/id/ENSBTAG00000011556" } ] } } ], "crossref": [ { "id": "A0AAF6YW66", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YW66", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR009332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12434", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12434", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12434:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12434:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVSHQVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLIALRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDPDTDSTDCLSAPLLASPEPSAGGPLQAAAPTHSHAGGPGPTEHA", "length": 205, "header": "tr|A0AAF6YW66-1|A0AAF6YW66_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 22 OS=Bos taurus OX=9913 GN=MED22 PE=4 SV=1 CANONICAL=A0AAF6YW66-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YW66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66/entry", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVSHQVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLIALRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDPDTDSTDCLSAPLLASPEPSAGGPLQAAAPTHSHAGGPGPTEHA", "length": 205, "header": "tr|A0AAF6YW66-1|A0AAF6YW66_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 22 OS=Bos taurus OX=9913 GN=MED22 PE=4 SV=1 CANONICAL=A0AAF6YW66-1" }, "locus": { "chromosome": "11", "start_pos": 104255102, "end_pos": 104249686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015357.3", "url": "https://www.ensembl.org/id/ENSBTAT00000015357.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015357.2", "url": "https://www.ensembl.org/id/ENSBTAP00000015357.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 202, "start_aa": "Thr", "end_pos": 202, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr202", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 202 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YW73-1", "uniprot_ac": "A0AAF6YW73", "uniprot_id": "A0AAF6YW73_BOVIN", "mass": { "chemical_mass": 36103.0, "monoisotopic_mass": 36103.0 }, "refseq": { "ac": "XP_024855940", "name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855940" }, "gene_names": [ { "name": "NAXD", "type": "recommended", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ] }, { "name": "CARKD", "type": "synonym", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ] }, { "name": "NAXD", "type": "synonym", "evidence": [ { "id": "XP_024855940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855940" } ] } ], "protein_names": [ { "name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase", "type": "recommended", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.93", "type": "synonym", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024855940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855940" } ] }, { "name": "ATP-dependent NAD(P)HX dehydratase", "type": "synonym", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73/entry#names_and_taxonomy" } ] }, { "name": "Carbohydrate kinase domain-containing protein", "type": "synonym", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73#function" }, { "database": "HAMAP", "id": "MF_03157", "url": "https://hamap.expasy.org/signature/MF_03157" }, { "database": "UniProtKB", "id": "ARBA00057267", "url": "https://www.uniprot.org/uniprotkb/ARBA00057267#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAXD", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73", "locus": { "chromosome": "12", "start_pos": 85237944, "end_pos": 85224847, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011466", "url": "https://www.ensembl.org/id/ENSBTAG00000011466" } ] } } ], "crossref": [ { "id": "A0AAF6YW73", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YW73", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01171", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01171", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613996", "url": "https://www.ncbi.nlm.nih.gov/gene/613996", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12592:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12592:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024855940", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855940", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19017", "url": "https://www.rhea-db.org/rhea/19017", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "32231", "url": "https://www.rhea-db.org/rhea/32231", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVRAGAAVAGAAVVAVLSAALALYGPPLDAVLKRAFSLHKAHSVKDMESILQLVRSVVPALTTKKHKGQDGRIGVVGGCREYTGAPYFAAISALKVGADLSHVFCTQEAAPVIKAYSPELIVHPVLDSPEAVRDVEQWLPRLHALVVGPGLGRDDALLENVKGILEASKARGIPVVIDADGLWLIAQQPALIQGYRKAVLTPNHVEFGRLSEAVLGVPLDGGDRHGAVLRLSQALGNVTVVQKGEQDVISDGEQVLECSQEGSGRRCGGQGDLLSGSLGVLAHWALRAGPQKTGGPSPLLVAAFGACALTRQCSQQAFQKYGRATTTSDMVAEVGPAFRRLFEA", "length": 345, "header": "tr|A0AAF6YW73-1|A0AAF6YW73_BOVIN Isoform 1 of ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Bos taurus OX=9913 GN=NAXD PE=3 SV=1 CANONICAL=A0AAF6YW73-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YW73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73/entry", "sequence": { "sequence": "MAVRAGAAVAGAAVVAVLSAALALYGPPLDAVLKRAFSLHKAHSVKDMESILQLVRSVVPALTTKKHKGQDGRIGVVGGCREYTGAPYFAAISALKVGADLSHVFCTQEAAPVIKAYSPELIVHPVLDSPEAVRDVEQWLPRLHALVVGPGLGRDDALLENVKGILEASKARGIPVVIDADGLWLIAQQPALIQGYRKAVLTPNHVEFGRLSEAVLGVPLDGGDRHGAVLRLSQALGNVTVVQKGEQDVISDGEQVLECSQEGSGRRCGGQGDLLSGSLGVLAHWALRAGPQKTGGPSPLLVAAFGACALTRQCSQQAFQKYGRATTTSDMVAEVGPAFRRLFEA", "length": 345, "header": "tr|A0AAF6YW73-1|A0AAF6YW73_BOVIN Isoform 1 of ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Bos taurus OX=9913 GN=NAXD PE=3 SV=1 CANONICAL=A0AAF6YW73-1" }, "locus": { "chromosome": "12", "start_pos": 85236940, "end_pos": 85224987, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015238.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015238.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015238.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015238.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP-dependent NAD(P)H-hydrate dehydratase activity", "id": "GO:0047453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047453", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nicotinamide nucleotide metabolic process", "id": "GO:0046496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YW73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19017", "name": "", "equation": "(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YW73-1", "E1BNQ4-1" ], "evidence": [ { "id": "19017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19017" } ] }, { "id": "32231", "name": "", "equation": "(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YW73-1", "E1BNQ4-1" ], "evidence": [ { "id": "32231", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32231" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YW73", "gene_name": "NAXD", "activity": [ { "ec_number": "4.2.1.93", "activity": "(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+).", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ] }, { "ec_number": "4.2.1.93", "activity": "", "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" } ] } ] }, { "uniprot_ac": "E1BNQ4", "gene_name": "NAXD", "activity": [ { "ec_number": "4.2.1.93", "activity": "(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+).", "evidence": [ { "id": "E1BNQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ4" } ] }, { "ec_number": "4.2.1.93", "activity": "", "evidence": [ { "id": "E1BNQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YW73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW73" }, { "id": "PS51383", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51383" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YjeF C-terminal", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 342, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.93", "ec_name": "(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+).", "evidence": [ { "id": "4.2.1.93", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.93" }, { "id": "4.2.1.93", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.93" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YWP8-1", "uniprot_ac": "A0AAF6YWP8", "uniprot_id": "A0AAF6YWP8_BOVIN", "mass": { "chemical_mass": 37137.0, "monoisotopic_mass": 37137.0 }, "refseq": {}, "gene_names": [ { "name": "ASNA1", "type": "recommended", "evidence": [ { "id": "A0AAF6YWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ] }, { "name": "GET3", "type": "synonym", "evidence": [ { "id": "A0AAF6YWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ] } ], "protein_names": [ { "name": "Guided entry of tail-anchored proteins factor 3, ATPase", "type": "synonym", "evidence": [ { "id": "A0AAF6YWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8#function" }, { "database": "HAMAP", "id": "MF_03112", "url": "https://hamap.expasy.org/signature/MF_03112" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8", "locus": {} } ], "crossref": [ { "id": "A0AAF6YWP8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YWP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02035", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02035", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10803:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10803:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02374", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02374", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVDS", "length": 333, "header": "tr|A0AAF6YWP8-1|A0AAF6YWP8_BOVIN Isoform 1 of Guided entry of tail-anchored proteins factor 3, ATPase OS=Bos taurus OX=9913 GN=ASNA1 PE=3 SV=1 CANONICAL=A0AAF6YWP8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YWP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8/entry", "sequence": { "sequence": "MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVDS", "length": 333, "header": "tr|A0AAF6YWP8-1|A0AAF6YWP8_BOVIN Isoform 1 of Guided entry of tail-anchored proteins factor 3, ATPase OS=Bos taurus OX=9913 GN=ASNA1 PE=3 SV=1 CANONICAL=A0AAF6YWP8-1" }, "locus": { "chromosome": "7", "start_pos": 12779195, "end_pos": 12769494, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015719.8", "url": "https://www.ensembl.org/id/ENSBTAT00000015719.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015719.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015719.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" }, { "name": "protein carrier chaperone", "id": "GO:0140597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140597", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" }, { "name": "GET complex", "id": "GO:0043529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043529", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" }, { "id": "PF02374", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02374" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ArsA/GET3 Anion-transporting ATPase-like", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 332, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "A0AAF6YWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" }, { "id": "MF_03112", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03112" } ], "binding_site_uniprot": 289, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared between dimeric partners", "eco_id": "ECO_0000256", "start_pos": 289, "end_pos": 289, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWP8" }, { "id": "MF_03112", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03112" } ], "binding_site_uniprot": 292, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared between dimeric partners", "eco_id": "ECO_0000256", "start_pos": 292, "end_pos": 292, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YWY0-1", "uniprot_ac": "A0AAF6YWY0", "uniprot_id": "A0AAF6YWY0_BOVIN", "mass": { "chemical_mass": 84751.0, "monoisotopic_mass": 84751.0 }, "refseq": { "ac": "XP_005203548", "name": "olfactomedin-like protein 2B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203548" }, "gene_names": [ { "name": "OLFML2B", "type": "recommended", "evidence": [ { "id": "A0AAF6YWY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" } ] }, { "name": "OLFML2B", "type": "synonym", "evidence": [ { "id": "XP_005203548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203548" } ] } ], "protein_names": [ { "name": "Olfactomedin like 2B", "type": "synonym", "evidence": [ { "id": "A0AAF6YWY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0/entry#names_and_taxonomy" } ] }, { "name": "olfactomedin-like protein 2B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005203548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203548" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OLFML2B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0", "locus": { "chromosome": "3", "start_pos": 7580207, "end_pos": 7531041, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034147", "url": "https://www.ensembl.org/id/ENSBTAG00000034147" } ] } } ], "crossref": [ { "id": "A0AAF6YWY0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YWY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "513053", "url": "https://www.ncbi.nlm.nih.gov/gene/513053", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050605", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050605", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23192:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23192:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203548", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203548", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YWY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKSLLLVLCFALVTTLGWGYSAPPTGTTEPPDVQTVAPTEDETLQNEADNQENVLSQLLGDYDKVKAVSEGSDCQCKCVVRPLGRDACQRVNAGTSRKEDFYTVETITSGPSCKCACVAPPSALNPCEGDFRLQKLREADSRDLKLSTIIDMLEGAFYGLDLLKLHSVTTKLVGRVDKLEEEISKNLTKENEQIREDVEEIRTEMNKRGKENCSNNILDSIPDIRSALQRDAAAAYTHPEEQYEERFLQEETVSQQIKSIKLLQTRPLAPPEVVKPQRPLQRQVHLRGRPASRPTVIRGITYYKAKDPEEENDIEEHQDEFFSGEHGMDLLIEDQLLRHNQLLTSATRRPAATGRSAAVTADAGTTSAGTPTTALPSARLPASTAAPSTPDPAVSASVEQFSTPLPTTSVSPDPTEEAVPTPFTQVPATTVAHTATQQPPASAPPSAAPEDAFVEATHTAPVPPPPVRTDSPGKDSTARQGTVPPGPTLSPEEEDDIRNVIGRCKDTLSTITGPITQNTYGRNEGAWMKDPLAKDERIYVTNYYYGNTLVEFRNLENFKQGRWSNSYKLPYSWIGTGHVVYNGAFYYNRAFTRNIIKYDLKQRYVAAWAMLHDVAYEEATPWRWQGHSDVDFAVDENGLWLIYPALDDEGFSQEVIVLSKLNAVDLSTQKETTWRTGLRRNLYGNCFVICGVLYAVDSHNQRNANISYAFDTHTNTQIVPRLLFENEYSYTTQIDYNPKDRLLYAWDNGHQVTYHVIFAY", "length": 761, "header": "tr|A0AAF6YWY0-1|A0AAF6YWY0_BOVIN Isoform 1 of Olfactomedin like 2B OS=Bos taurus OX=9913 GN=OLFML2B PE=4 SV=1 CANONICAL=A0AAF6YWY0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YWY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0/entry", "sequence": { "sequence": "MAKSLLLVLCFALVTTLGWGYSAPPTGTTEPPDVQTVAPTEDETLQNEADNQENVLSQLLGDYDKVKAVSEGSDCQCKCVVRPLGRDACQRVNAGTSRKEDFYTVETITSGPSCKCACVAPPSALNPCEGDFRLQKLREADSRDLKLSTIIDMLEGAFYGLDLLKLHSVTTKLVGRVDKLEEEISKNLTKENEQIREDVEEIRTEMNKRGKENCSNNILDSIPDIRSALQRDAAAAYTHPEEQYEERFLQEETVSQQIKSIKLLQTRPLAPPEVVKPQRPLQRQVHLRGRPASRPTVIRGITYYKAKDPEEENDIEEHQDEFFSGEHGMDLLIEDQLLRHNQLLTSATRRPAATGRSAAVTADAGTTSAGTPTTALPSARLPASTAAPSTPDPAVSASVEQFSTPLPTTSVSPDPTEEAVPTPFTQVPATTVAHTATQQPPASAPPSAAPEDAFVEATHTAPVPPPPVRTDSPGKDSTARQGTVPPGPTLSPEEEDDIRNVIGRCKDTLSTITGPITQNTYGRNEGAWMKDPLAKDERIYVTNYYYGNTLVEFRNLENFKQGRWSNSYKLPYSWIGTGHVVYNGAFYYNRAFTRNIIKYDLKQRYVAAWAMLHDVAYEEATPWRWQGHSDVDFAVDENGLWLIYPALDDEGFSQEVIVLSKLNAVDLSTQKETTWRTGLRRNLYGNCFVICGVLYAVDSHNQRNANISYAFDTHTNTQIVPRLLFENEYSYTTQIDYNPKDRLLYAWDNGHQVTYHVIFAY", "length": 761, "header": "tr|A0AAF6YWY0-1|A0AAF6YWY0_BOVIN Isoform 1 of Olfactomedin like 2B OS=Bos taurus OX=9913 GN=OLFML2B PE=4 SV=1 CANONICAL=A0AAF6YWY0-1" }, "locus": { "chromosome": "3", "start_pos": 7579730, "end_pos": 7531082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015933.8", "url": "https://www.ensembl.org/id/ENSBTAT00000015933.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015933.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015933.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 489, "start_aa": "Thr", "end_pos": 489, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr489", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" } ], "pmid": "" }, { "name": "extracellular matrix binding", "id": "GO:0050840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050840", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YWY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 706, "end_pos": 708, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YWY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWY0" }, { "id": "PS51132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Olfactomedin-like", "eco_id": "ECO_0000259", "start_pos": 504, "end_pos": 761, "start_aa": "Arg", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 489 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 }, { "start_pos": 213, "end_pos": 215 }, { "start_pos": 706, "end_pos": 708 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YXD6-1", "uniprot_ac": "A0AAF6YXD6", "uniprot_id": "A0AAF6YXD6_BOVIN", "mass": { "chemical_mass": 19463.0, "monoisotopic_mass": 19463.0 }, "refseq": { "ac": "XP_024838217", "name": "CCHC-type zinc finger nucleic acid binding protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838217" }, "gene_names": [ { "name": "CNBP", "type": "recommended", "evidence": [ { "id": "A0AAF6YXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ] }, { "name": "CNBP", "type": "synonym", "evidence": [ { "id": "XP_024838217", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838217" } ] } ], "protein_names": [ { "name": "CCHC-type zinc finger nucleic acid binding protein", "type": "recommended", "evidence": [ { "id": "A0AAF6YXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6/entry#names_and_taxonomy" } ] }, { "name": "CCHC-type zinc finger nucleic acid binding protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838217", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838217" } ] }, { "name": "Cellular nucleic acid-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAF6YXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 9", "type": "synonym", "evidence": [ { "id": "A0AAF6YXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNBP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6", "locus": { "chromosome": "22", "start_pos": 59070589, "end_pos": 59080268, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012159", "url": "https://www.ensembl.org/id/ENSBTAG00000012159" } ] } } ], "crossref": [ { "id": "A0AAF6YXD6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YXD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "504831", "url": "https://www.ncbi.nlm.nih.gov/gene/504831", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47103:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47103:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838217", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838217", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 177, "header": "tr|A0AAF6YXD6-1|A0AAF6YXD6_BOVIN Isoform 1 of CCHC-type zinc finger nucleic acid binding protein OS=Bos taurus OX=9913 GN=CNBP PE=4 SV=1 CANONICAL=A0AAF6YXD6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YXD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6/entry", "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 177, "header": "tr|A0AAF6YXD6-1|A0AAF6YXD6_BOVIN Isoform 1 of CCHC-type zinc finger nucleic acid binding protein OS=Bos taurus OX=9913 GN=CNBP PE=4 SV=1 CANONICAL=A0AAF6YXD6-1" }, "locus": { "chromosome": "22", "start_pos": 59072828, "end_pos": 59071461, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016130.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016130.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016130.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016130.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" }, { "name": "G-quadruplex DNA formation", "id": "GO:0071919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071919", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" }, { "name": "G-quadruplex DNA binding", "id": "GO:0051880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051880", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXD6" }, { "id": "PS50158", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC-type", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 20, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YXF5-1", "uniprot_ac": "A0AAF6YXF5", "uniprot_id": "A0AAF6YXF5_BOVIN", "mass": { "chemical_mass": 34829.0, "monoisotopic_mass": 34829.0 }, "refseq": {}, "gene_names": [ { "name": "RAB19", "type": "recommended", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ], "protein_names": [ { "name": "Ras-related protein Rab-19", "type": "recommended", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5#function" }, { "database": "UniProtKB", "id": "ARBA00057434", "url": "https://www.uniprot.org/uniprotkb/ARBA00057434#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5", "locus": { "chromosome": "4", "start_pos": 103806850, "end_pos": 103792919, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012261", "url": "https://www.ensembl.org/id/ENSBTAG00000012261" } ] } } ], "crossref": [ { "id": "A0AAF6YXF5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YXF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01864", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01864", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47979", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47979", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPWPPSGTDRCQVFLEINLCFGVDFEGGRKLFFSALKEIKDSATKPDTWGTELQFPPHLEAGGRRGTEGQKEKQEKEQTPAGRREQQVARAMQFSSSARTVDENFDYLFKIILIGDSNVGKTCVVQHFKSGVYMEAQQNTIGVDFTVRALEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKCDLWEKRHVLFEDACILAEKYGLLAVLETSAKESKNIDEVFVLMARELMARHSLPLYGEGAPGSLPLESTPVLMAPAPREKNQCTC", "length": 309, "header": "tr|A0AAF6YXF5-1|A0AAF6YXF5_BOVIN Isoform 1 of Ras-related protein Rab-19 OS=Bos taurus OX=9913 GN=RAB19 PE=3 SV=1 CANONICAL=A0AAF6YXF5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YXF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5/entry", "sequence": { "sequence": "MLPWPPSGTDRCQVFLEINLCFGVDFEGGRKLFFSALKEIKDSATKPDTWGTELQFPPHLEAGGRRGTEGQKEKQEKEQTPAGRREQQVARAMQFSSSARTVDENFDYLFKIILIGDSNVGKTCVVQHFKSGVYMEAQQNTIGVDFTVRALEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESVPHWIHEIEKYGAANLVIMLIGNKCDLWEKRHVLFEDACILAEKYGLLAVLETSAKESKNIDEVFVLMARELMARHSLPLYGEGAPGSLPLESTPVLMAPAPREKNQCTC", "length": 309, "header": "tr|A0AAF6YXF5-1|A0AAF6YXF5_BOVIN Isoform 1 of Ras-related protein Rab-19 OS=Bos taurus OX=9913 GN=RAB19 PE=3 SV=1 CANONICAL=A0AAF6YXF5-1" }, "locus": { "chromosome": "4", "start_pos": 103805481, "end_pos": 103792954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016258.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016258.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016258.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016258.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YXM8-1", "uniprot_ac": "A0AAF6YXM8", "uniprot_id": "A0AAF6YXM8_BOVIN", "mass": { "chemical_mass": 63706.0, "monoisotopic_mass": 63706.0 }, "refseq": {}, "gene_names": [ { "name": "PIGB", "type": "recommended", "evidence": [ { "id": "A0AAF6YXM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8" } ] } ], "protein_names": [ { "name": "Mannosyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6YXM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "A0AAF6YXM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8", "locus": { "chromosome": "10", "start_pos": 54973408, "end_pos": 54998890, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012740", "url": "https://www.ensembl.org/id/ENSBTAG00000012740" } ] } } ], "crossref": [ { "id": "A0AAF6YXM8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YXM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22760", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22760", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22760:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22760:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "61000", "url": "https://www.rhea-db.org/rhea/61000", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61004", "url": "https://www.rhea-db.org/rhea/61004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YXM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERDDGGGGGLFFRGLQNRSHEKTKLRTRKSTLYLSPQKSTGRCGDLGENIYLVLFIIALRICNCFLVQTSFVPDEYWQSLEVAHRMVFNNYGYLTWEWTERLRGYTYPLIFASIYKILHLLGKDSVHLLIWIPRLAQALLSAIADLRLYSLMKQLENQQVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVIPWIPLLFRHFWQEQRKLDLILHQFLPVGFVTLSLSLIIDRIFFGQWTLVQYNFLKFNVLQDLGSFYGSHPWHWYFSQGFPAVLGTHLPFFIHGCFLAPKRYRIFLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLNNLKTWKKPALSFLFLSNMLLALYTGLVHQRGTLDVMTNIQELSYNNTNVSSASVLMMMPCHSTPYYSHVHYPLPMRFLQCPPDLTGKTDYLVEADMFYLNPLKWLYMEFQNDSQLPTHLIMFSVLEEEISPFLISNNYERTAVFFHTHFPESRTGSHIYVYERKLKGKLNQR", "length": 542, "header": "tr|A0AAF6YXM8-1|A0AAF6YXM8_BOVIN Isoform 1 of Mannosyltransferase OS=Bos taurus OX=9913 GN=PIGB PE=3 SV=1 CANONICAL=A0AAF6YXM8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YXM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8/entry", "sequence": { "sequence": "MERDDGGGGGLFFRGLQNRSHEKTKLRTRKSTLYLSPQKSTGRCGDLGENIYLVLFIIALRICNCFLVQTSFVPDEYWQSLEVAHRMVFNNYGYLTWEWTERLRGYTYPLIFASIYKILHLLGKDSVHLLIWIPRLAQALLSAIADLRLYSLMKQLENQQVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVIPWIPLLFRHFWQEQRKLDLILHQFLPVGFVTLSLSLIIDRIFFGQWTLVQYNFLKFNVLQDLGSFYGSHPWHWYFSQGFPAVLGTHLPFFIHGCFLAPKRYRIFLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLNNLKTWKKPALSFLFLSNMLLALYTGLVHQRGTLDVMTNIQELSYNNTNVSSASVLMMMPCHSTPYYSHVHYPLPMRFLQCPPDLTGKTDYLVEADMFYLNPLKWLYMEFQNDSQLPTHLIMFSVLEEEISPFLISNNYERTAVFFHTHFPESRTGSHIYVYERKLKGKLNQR", "length": 542, "header": "tr|A0AAF6YXM8-1|A0AAF6YXM8_BOVIN Isoform 1 of Mannosyltransferase OS=Bos taurus OX=9913 GN=PIGB PE=3 SV=1 CANONICAL=A0AAF6YXM8-1" }, "locus": { "chromosome": "10", "start_pos": 54998846, "end_pos": 54973640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016934.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016934.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016934.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016934.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dol-P-Man:Man(2)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity", "id": "GO:0120564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120564", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "61000", "name": "", "equation": "a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-(alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YXM8-1", "Q1LZA0-1" ], "evidence": [ { "id": "61000", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61000" } ] }, { "id": "61004", "name": "", "equation": "a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YXM8-1", "Q1LZA0-1" ], "evidence": [ { "id": "61004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YXM8", "gene_name": "PIGB", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAF6YXM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXM8" } ] } ] }, { "uniprot_ac": "Q1LZA0", "gene_name": "PIGB", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q1LZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 481, "end_pos": 483 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YY22-1", "uniprot_ac": "A0AAF6YY22", "uniprot_id": "A0AAF6YY22_BOVIN", "mass": { "chemical_mass": 29352.0, "monoisotopic_mass": 29352.0 }, "refseq": {}, "gene_names": [ { "name": "UBTD1", "type": "recommended", "evidence": [ { "id": "A0AAF6YY22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22" } ] } ], "protein_names": [ { "name": "Ubiquitin domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YY22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBTD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22", "locus": { "chromosome": "26", "start_pos": 18760653, "end_pos": 18755901, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012719", "url": "https://www.ensembl.org/id/ENSBTAG00000012719" } ] } } ], "crossref": [ { "id": "A0AAF6YY22", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YY22", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17120", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17120", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YY22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YY22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLLFIFLGTSSREFFEAWFEVVFLQRGFAFPCANPGTLQIKRLALEFSVCTGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHTQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 256, "header": "tr|A0AAF6YY22-1|A0AAF6YY22_BOVIN Isoform 1 of Ubiquitin domain containing 1 OS=Bos taurus OX=9913 GN=UBTD1 PE=4 SV=1 CANONICAL=A0AAF6YY22-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YY22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22/entry", "sequence": { "sequence": "MTLLFIFLGTSSREFFEAWFEVVFLQRGFAFPCANPGTLQIKRLALEFSVCTGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHTQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD", "length": 256, "header": "tr|A0AAF6YY22-1|A0AAF6YY22_BOVIN Isoform 1 of Ubiquitin domain containing 1 OS=Bos taurus OX=9913 GN=UBTD1 PE=4 SV=1 CANONICAL=A0AAF6YY22-1" }, "locus": { "chromosome": "26", "start_pos": 18759948, "end_pos": 18756100, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016906.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016906.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016906.4", "url": "https://www.ensembl.org/id/ENSBTAP00000016906.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 171, "start_aa": "Thr", "end_pos": 171, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr171", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YY22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY22" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 178, "end_pos": 253, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 171 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YY77-1", "uniprot_ac": "A0AAF6YY77", "uniprot_id": "A0AAF6YY77_BOVIN", "mass": { "chemical_mass": 24117.0, "monoisotopic_mass": 24117.0 }, "refseq": {}, "gene_names": [ { "name": "SDF2", "type": "recommended", "evidence": [ { "id": "A0AAF6YY77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ] } ], "protein_names": [ { "name": "Stromal cell derived factor 2", "type": "synonym", "evidence": [ { "id": "A0AAF6YY77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77", "locus": { "chromosome": "19", "start_pos": 20091090, "end_pos": 20098364, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012845", "url": "https://www.ensembl.org/id/ENSBTAG00000012845" } ] } } ], "crossref": [ { "id": "A0AAF6YY77", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YY77", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46809", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46809", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46809:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46809:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YY77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVVSLLLFGGLWSAVGSSNLAVVTCGSVVKLLNTRHNVRLHSHDVRYGSDINFFLTTGSGQQSVTGVTSVDDSNSYWRIRGKTATVCERGTPIRCGQPIRLTHVNTGRNLHSHHFTSPLSGNQEVSAFGEEGEGDYLDDWTVLCNGPYWVRDGEVRFKHSSTEVLLSVTGEQYGRPISGQKEVHGMAQPSQNNYWKAMEGIFMKPSELLKAEGHHTEL", "length": 219, "header": "tr|A0AAF6YY77-1|A0AAF6YY77_BOVIN Isoform 1 of Stromal cell derived factor 2 OS=Bos taurus OX=9913 GN=SDF2 PE=4 SV=1 CANONICAL=A0AAF6YY77-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YY77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77/entry", "sequence": { "sequence": "MAVVSLLLFGGLWSAVGSSNLAVVTCGSVVKLLNTRHNVRLHSHDVRYGSDINFFLTTGSGQQSVTGVTSVDDSNSYWRIRGKTATVCERGTPIRCGQPIRLTHVNTGRNLHSHHFTSPLSGNQEVSAFGEEGEGDYLDDWTVLCNGPYWVRDGEVRFKHSSTEVLLSVTGEQYGRPISGQKEVHGMAQPSQNNYWKAMEGIFMKPSELLKAEGHHTEL", "length": 219, "header": "tr|A0AAF6YY77-1|A0AAF6YY77_BOVIN Isoform 1 of Stromal cell derived factor 2 OS=Bos taurus OX=9913 GN=SDF2 PE=4 SV=1 CANONICAL=A0AAF6YY77-1" }, "locus": { "chromosome": "19", "start_pos": 20098165, "end_pos": 20091125, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017066.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017066.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017066.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017066.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ], "pmid": "" }, { "name": "protein folding chaperone complex", "id": "GO:0101031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein refolding", "id": "GO:0042026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY77", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YY77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY77" }, { "id": "PS50919", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50919" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIR", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 83, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YY86-1", "uniprot_ac": "A0AAF6YY86", "uniprot_id": "A0AAF6YY86_BOVIN", "mass": { "chemical_mass": 27943.0, "monoisotopic_mass": 27943.0 }, "refseq": {}, "gene_names": [ { "name": "UNC119", "type": "recommended", "evidence": [ { "id": "A0AAF6YY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ] } ], "protein_names": [ { "name": "Protein unc-119 homolog A", "type": "recommended", "evidence": [ { "id": "A0AAF6YY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86#function" }, { "database": "UniProtKB", "id": "ARBA00045349", "url": "https://www.uniprot.org/uniprotkb/ARBA00045349#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UNC119", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86", "locus": { "chromosome": "19", "start_pos": 20009078, "end_pos": 20015144, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013096", "url": "https://www.ensembl.org/id/ENSBTAG00000013096" } ] } } ], "crossref": [ { "id": "A0AAF6YY86", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YY86", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12951", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12951", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12951:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12951:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YY86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVKKGGGGAGTGAEHAPGASGPNVEPKPELQAESESGSESEPEAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPASERLPINPRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPALSEELSALGGVDSEGPVNEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 251, "header": "tr|A0AAF6YY86-1|A0AAF6YY86_BOVIN Isoform 1 of Protein unc-119 homolog A OS=Bos taurus OX=9913 GN=UNC119 PE=3 SV=1 CANONICAL=A0AAF6YY86-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YY86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86/entry", "sequence": { "sequence": "MKVKKGGGGAGTGAEHAPGASGPNVEPKPELQAESESGSESEPEAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPASERLPINPRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPALSEELSALGGVDSEGPVNEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 251, "header": "tr|A0AAF6YY86-1|A0AAF6YY86_BOVIN Isoform 1 of Protein unc-119 homolog A OS=Bos taurus OX=9913 GN=UNC119 PE=3 SV=1 CANONICAL=A0AAF6YY86-1" }, "locus": { "chromosome": "19", "start_pos": 20015104, "end_pos": 20010082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017411.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017411.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017411.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017411.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "spindle midzone", "id": "GO:0051233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051233", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "lipoprotein transport", "id": "GO:0042953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042953", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "negative regulation of caveolin-mediated endocytosis", "id": "GO:2001287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" }, { "name": "negative regulation of clathrin-dependent endocytosis", "id": "GO:1900186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900186", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YY86", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YY86" }, { "id": "PF05351", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05351" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GMP phosphodiesterase delta subunit", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 247, "start_aa": "Glu", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YYJ2-1", "uniprot_ac": "A0AAF6YYJ2", "uniprot_id": "A0AAF6YYJ2_BOVIN", "mass": { "chemical_mass": 74074.0, "monoisotopic_mass": 74074.0 }, "refseq": {}, "gene_names": [ { "name": "PLCZ1", "type": "recommended", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ] } ], "protein_names": [ { "name": "Phosphoinositide phospholipase C", "type": "recommended", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.11", "type": "synonym", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2#function" }, { "database": "UniProtKB", "id": "ARBA00003992", "url": "https://www.uniprot.org/uniprotkb/ARBA00003992#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLCZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2", "locus": { "chromosome": "5", "start_pos": 91384524, "end_pos": 91335807, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013202", "url": "https://www.ensembl.org/id/ENSBTAG00000013202" } ] } } ], "crossref": [ { "id": "A0AAF6YYJ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YYJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00275", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00275", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00387", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00387", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09279", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09279", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "33179", "url": "https://www.rhea-db.org/rhea/33179", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENKWFLLMVRDDFKGGKITLEKALKLLEKLDIQCNTIHVKYIFKDNDRLKQGRITIEEFRTIYRIITYREEIIEIFNTYSENRKILLEKNLVEFLMREQYTLDFNKSIASEIIQKYEPIEEVKQAHQMSFEGFRRYMDSSECLLFDNKCDHVYQDMTHPLTDYFISSSHNTYLISDQLWGPSDLWGYISALVKGCRCLEIDCWDGSQNEPVVYHGYTFTSKLLFKTVIQAINKYAFLASEYPVVLSLENHCSPSQQEVMADSLLATFGDALLSYTLDNFSDRLPSPEALKFKILVRNKKIGTLHETLERKGSDMHGKVEEFEEEEEIEQEEDGSGAKEPEPVGDFQDDLAKEEQLKRVVGIPLFRKKKITKIKISMALSDLVIYTKVEKFKSFHHSHLYQQFNESNSIGESQARKLTKLAAREFILHTRRFITRVYPKALRADSSNFNPQEFWNVGCQMVALNFQTPGVPMDLQNGKFLDNGCSGYVLKPRFLRDKKTKFNPHKVQIDSNPLTLTIRLISGIQLPPSYQNKADTLVIVEIFGVPNDQMKQQSRVIKKNAFNPRWNETFTFVIQVPELALIRFVAENQGLIAGNEFLGQYTLPVLCMNRGYRRVPLFSKMGESLEPASLFIYVWYIR", "length": 637, "header": "tr|A0AAF6YYJ2-1|A0AAF6YYJ2_BOVIN Isoform 1 of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCZ1 PE=4 SV=1 CANONICAL=A0AAF6YYJ2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YYJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2/entry", "sequence": { "sequence": "MENKWFLLMVRDDFKGGKITLEKALKLLEKLDIQCNTIHVKYIFKDNDRLKQGRITIEEFRTIYRIITYREEIIEIFNTYSENRKILLEKNLVEFLMREQYTLDFNKSIASEIIQKYEPIEEVKQAHQMSFEGFRRYMDSSECLLFDNKCDHVYQDMTHPLTDYFISSSHNTYLISDQLWGPSDLWGYISALVKGCRCLEIDCWDGSQNEPVVYHGYTFTSKLLFKTVIQAINKYAFLASEYPVVLSLENHCSPSQQEVMADSLLATFGDALLSYTLDNFSDRLPSPEALKFKILVRNKKIGTLHETLERKGSDMHGKVEEFEEEEEIEQEEDGSGAKEPEPVGDFQDDLAKEEQLKRVVGIPLFRKKKITKIKISMALSDLVIYTKVEKFKSFHHSHLYQQFNESNSIGESQARKLTKLAAREFILHTRRFITRVYPKALRADSSNFNPQEFWNVGCQMVALNFQTPGVPMDLQNGKFLDNGCSGYVLKPRFLRDKKTKFNPHKVQIDSNPLTLTIRLISGIQLPPSYQNKADTLVIVEIFGVPNDQMKQQSRVIKKNAFNPRWNETFTFVIQVPELALIRFVAENQGLIAGNEFLGQYTLPVLCMNRGYRRVPLFSKMGESLEPASLFIYVWYIR", "length": 637, "header": "tr|A0AAF6YYJ2-1|A0AAF6YYJ2_BOVIN Isoform 1 of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCZ1 PE=4 SV=1 CANONICAL=A0AAF6YYJ2-1" }, "locus": { "chromosome": "5", "start_pos": 91384462, "end_pos": 91336506, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017574.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017574.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017574.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017574.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "sperm head", "id": "GO:0061827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061827", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "pronucleus", "id": "GO:0045120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045120", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" }, { "name": "positive regulation of cytosolic calcium ion concentration involved in egg activation", "id": "GO:0060470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060470", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 404, "end_pos": 406, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33179", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SDK5-1", "A0AAA9S613-1", "G3N0S6-1", "F1MF11-1", "E1BH60-1", "A0A3Q1NG43-1", "P10895-1", "A0AAF6YYJ2-1", "P10894-1", "P21671-1", "P08487-1", "Q07722-1", "Q1RML2-1", "A7MB47-1", "F1MSD7-1", "E1B7M6-1", "A0A3Q1MTC3-1", "A0AAA9SMQ6-1" ], "evidence": [ { "id": "33179", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33179" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MTC3", "gene_name": "PLCL1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A3Q1MTC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTC3" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A3Q1MTC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTC3" } ] } ] }, { "uniprot_ac": "A0A3Q1NG43", "gene_name": "PLCE1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A3Q1NG43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG43" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A3Q1NG43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG43" } ] } ] }, { "uniprot_ac": "A0AAA9S613", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9S613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S613" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9S613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S613" } ] } ] }, { "uniprot_ac": "A0AAA9SDK5", "gene_name": "PLCD3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] } ] }, { "uniprot_ac": "A0AAA9SMQ6", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9SMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9SMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ6" } ] } ] }, { "uniprot_ac": "A0AAF6YYJ2", "gene_name": "PLCZ1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ] } ] }, { "uniprot_ac": "A7MB47", "gene_name": "CNOT9", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A7MB47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB47" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A7MB47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB47" } ] } ] }, { "uniprot_ac": "E1B7M6", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "E1B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "E1B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M6" } ] } ] }, { "uniprot_ac": "E1BH60", "gene_name": "PLCL2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "E1BH60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH60" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "E1BH60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH60" } ] } ] }, { "uniprot_ac": "F1MF11", "gene_name": "PLCH1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "F1MF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1MF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ] } ] }, { "uniprot_ac": "F1MSD7", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "F1MSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1MSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD7" } ] } ] }, { "uniprot_ac": "G3N0S6", "gene_name": "PLCH2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "G3N0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0S6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "G3N0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0S6" } ] } ] }, { "uniprot_ac": "P08487", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P08487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08487" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P08487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08487" } ] } ] }, { "uniprot_ac": "P10894", "gene_name": "PLCB1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10894" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10894" } ] } ] }, { "uniprot_ac": "P10895", "gene_name": "PLCD1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10895" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10895" } ] } ] }, { "uniprot_ac": "P21671", "gene_name": "PLCD4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P21671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21671" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P21671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21671" } ] } ] }, { "uniprot_ac": "Q07722", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q07722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07722" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q07722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07722" } ] } ] }, { "uniprot_ac": "Q1RML2", "gene_name": "PLCZ1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q1RML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML2" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q1RML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 495, "end_pos": 618, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 70, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" }, { "id": "PS50008", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50008" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PI-PLC Y-box", "eco_id": "ECO_0000259", "start_pos": 379, "end_pos": 495, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.4.11", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "3.1.4.11", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11" }, { "id": "3.1.4.11", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.11" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 279, "end_pos": 281 }, { "start_pos": 404, "end_pos": 406 }, { "start_pos": 566, "end_pos": 568 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YYN3-1", "uniprot_ac": "A0AAF6YYN3", "uniprot_id": "A0AAF6YYN3_BOVIN", "mass": { "chemical_mass": 69021.0, "monoisotopic_mass": 69021.0 }, "refseq": {}, "gene_names": [ { "name": "HSPA1A", "type": "recommended", "evidence": [ { "id": "A0AAF6YYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3" } ] } ], "protein_names": [ { "name": "Heat shock protein family A (Hsp70) member 1A", "type": "synonym", "evidence": [ { "id": "A0AAF6YYN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSPA1A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3", "locus": {} } ], "crossref": [ { "id": "A0AAF6YYN3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YYN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10233", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10233", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR013126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19375", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19375", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YYN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKNMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFRVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISRLYQGAGGPGAGGFGAQGPKGGSGSGPTIEEVD", "length": 628, "header": "tr|A0AAF6YYN3-1|A0AAF6YYN3_BOVIN Isoform 1 of Heat shock protein family A (Hsp70) member 1A OS=Bos taurus OX=9913 GN=HSPA1A PE=3 SV=1 CANONICAL=A0AAF6YYN3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YYN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3/entry", "sequence": { "sequence": "MAKNMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFRVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISRLYQGAGGPGAGGFGAQGPKGGSGSGPTIEEVD", "length": 628, "header": "tr|A0AAF6YYN3-1|A0AAF6YYN3_BOVIN Isoform 1 of Heat shock protein family A (Hsp70) member 1A OS=Bos taurus OX=9913 GN=HSPA1A PE=3 SV=1 CANONICAL=A0AAF6YYN3-1" }, "locus": { "chromosome": "23", "start_pos": 27522579, "end_pos": 27520657, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017500.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017500.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017500.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017500.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 623, "start_aa": "Thr", "end_pos": 623, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr623", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYN3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" }, { "start_pos": 404, "end_pos": 406, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 623 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 35, "end_pos": 37 }, { "start_pos": 404, "end_pos": 406 }, { "start_pos": 474, "end_pos": 476 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YYX7-1", "uniprot_ac": "A0AAF6YYX7", "uniprot_id": "A0AAF6YYX7_BOVIN", "mass": { "chemical_mass": 27084.0, "monoisotopic_mass": 27084.0 }, "refseq": {}, "gene_names": [ { "name": "GET1", "type": "recommended", "evidence": [ { "id": "A0AAF6YYX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7" } ] } ], "protein_names": [ { "name": "Guided entry of tail-anchored proteins factor 1", "type": "recommended", "evidence": [ { "id": "A0AAF6YYX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7/entry#names_and_taxonomy" } ] }, { "name": "Tail-anchored protein insertion receptor WRB", "type": "synonym", "evidence": [ { "id": "A0AAF6YYX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7/entry#names_and_taxonomy" } ] }, { "name": "Tryptophan-rich basic protein", "type": "synonym", "evidence": [ { "id": "A0AAF6YYX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GET1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7", "locus": { "chromosome": "1", "start_pos": 139458044, "end_pos": 139442827, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013629", "url": "https://www.ensembl.org/id/ENSBTAG00000013629" } ] } } ], "crossref": [ { "id": "A0AAF6YYX7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YYX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR028945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42650", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42650", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42650:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42650:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04420", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04420", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YYX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEPEEEGYGSQECQEIRRKDGPASRSAAQCAGAAAPLCGSQFSMRTRGRRRGPHGAALADPATPLASEMSAAEADRWAWLLVLSFVFGCNVLRILLPSFSFFMSRVLQKDAEQESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYILQAALMVSLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS", "length": 243, "header": "tr|A0AAF6YYX7-1|A0AAF6YYX7_BOVIN Isoform 1 of Guided entry of tail-anchored proteins factor 1 OS=Bos taurus OX=9913 GN=GET1 PE=3 SV=1 CANONICAL=A0AAF6YYX7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YYX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7/entry", "sequence": { "sequence": "MKEPEEEGYGSQECQEIRRKDGPASRSAAQCAGAAAPLCGSQFSMRTRGRRRGPHGAALADPATPLASEMSAAEADRWAWLLVLSFVFGCNVLRILLPSFSFFMSRVLQKDAEQESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYILQAALMVSLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS", "length": 243, "header": "tr|A0AAF6YYX7-1|A0AAF6YYX7_BOVIN Isoform 1 of Guided entry of tail-anchored proteins factor 1 OS=Bos taurus OX=9913 GN=GET1 PE=3 SV=1 CANONICAL=A0AAF6YYX7-1" }, "locus": { "chromosome": "1", "start_pos": 139457218, "end_pos": 139442896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018116.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018116.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018116.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018116.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYX7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZE7-1", "uniprot_ac": "A0AAF6YZE7", "uniprot_id": "A0AAF6YZE7_BOVIN", "mass": { "chemical_mass": 12510.0, "monoisotopic_mass": 12510.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM141", "type": "recommended", "evidence": [ { "id": "A0AAF6YZE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7" } ] } ], "protein_names": [ { "name": "Transmembrane protein 141", "type": "synonym", "evidence": [ { "id": "A0AAF6YZE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM141", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7", "locus": { "chromosome": "11", "start_pos": 105897519, "end_pos": 105895705, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013889", "url": "https://www.ensembl.org/id/ENSBTAG00000013889" } ] } } ], "crossref": [ { "id": "A0AAF6YZE7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47229:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47229:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YZE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVNLGLSRVDDAVASKHPVGWVPGVRRSHPDSPASGASSPARSAGSLEGTGATFGLQMLVQRKLPYPFQWKVLLAVVAGSVASYWVTRVESQKCSNLWLFLETGQLPKDMGTDRRS", "length": 116, "header": "tr|A0AAF6YZE7-1|A0AAF6YZE7_BOVIN Isoform 1 of Transmembrane protein 141 OS=Bos taurus OX=9913 GN=TMEM141 PE=4 SV=1 CANONICAL=A0AAF6YZE7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZE7/entry", "sequence": { "sequence": "MVNLGLSRVDDAVASKHPVGWVPGVRRSHPDSPASGASSPARSAGSLEGTGATFGLQMLVQRKLPYPFQWKVLLAVVAGSVASYWVTRVESQKCSNLWLFLETGQLPKDMGTDRRS", "length": 116, "header": "tr|A0AAF6YZE7-1|A0AAF6YZE7_BOVIN Isoform 1 of Transmembrane protein 141 OS=Bos taurus OX=9913 GN=TMEM141 PE=4 SV=1 CANONICAL=A0AAF6YZE7-1" }, "locus": { "chromosome": "11", "start_pos": 105897112, "end_pos": 105895786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018443.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018443.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018443.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018443.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZF4-1", "uniprot_ac": "A0AAF6YZF4", "uniprot_id": "A0AAF6YZF4_BOVIN", "mass": { "chemical_mass": 20250.0, "monoisotopic_mass": 20250.0 }, "refseq": {}, "gene_names": [ { "name": "RPS11", "type": "recommended", "evidence": [ { "id": "A0AAF6YZF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein uS17", "type": "recommended", "evidence": [ { "id": "A0AAF6YZF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S11", "type": "synonym", "evidence": [ { "id": "A0AAF6YZF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS11", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4", "locus": { "chromosome": "18", "start_pos": 55952929, "end_pos": 55950354, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013924", "url": "https://www.ensembl.org/id/ENSBTAG00000013924" } ] } } ], "crossref": [ { "id": "A0AAF6YZF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00364", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00364", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10744", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10744", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10744:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10744:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADIQVWATCRCRLCGVWVSEAKRAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF", "length": 174, "header": "tr|A0AAF6YZF4-1|A0AAF6YZF4_BOVIN Isoform 1 of Small ribosomal subunit protein uS17 OS=Bos taurus OX=9913 GN=RPS11 PE=3 SV=1 CANONICAL=A0AAF6YZF4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4/entry", "sequence": { "sequence": "MADIQVWATCRCRLCGVWVSEAKRAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF", "length": 174, "header": "tr|A0AAF6YZF4-1|A0AAF6YZF4_BOVIN Isoform 1 of Small ribosomal subunit protein uS17 OS=Bos taurus OX=9913 GN=RPS11 PE=3 SV=1 CANONICAL=A0AAF6YZF4-1" }, "locus": { "chromosome": "18", "start_pos": 55952879, "end_pos": 55950553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018491.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018491.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018491.2", "url": "https://www.ensembl.org/id/ENSBTAP00000018491.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YZF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZF4" }, { "id": "PF16205", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16205" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Small ribosomal subunit protein uS17 N-terminal", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 89, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZH3-1", "uniprot_ac": "A0AAF6YZH3", "uniprot_id": "A0AAF6YZH3_BOVIN", "mass": { "chemical_mass": 17240.0, "monoisotopic_mass": 17240.0 }, "refseq": {}, "gene_names": [ { "name": "ACYP1", "type": "recommended", "evidence": [ { "id": "A0AAF6YZH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3" } ] } ], "protein_names": [ { "name": "Acylphosphatase", "type": "recommended", "evidence": [ { "id": "A0AAF6YZH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.7", "type": "synonym", "evidence": [ { "id": "A0AAF6YZH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZH3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACYP1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3", "locus": { "chromosome": "10", "start_pos": 86307311, "end_pos": 86318449, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013992", "url": "https://www.ensembl.org/id/ENSBTAG00000013992" } ] } } ], "crossref": [ { "id": "A0AAF6YZH3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10029", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10029", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10029:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10029:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00708", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00708", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "14965", "url": "https://www.rhea-db.org/rhea/14965", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YZH3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSDPGVCPSLAKDGAPRCALRSFCRKIPVSALLLAGVGMLIAFLGTLGCLVPAPGLSMSMAEGDTLISVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTDQGTVQGQLQGPASKVRHMQEWLETKGSPKSHIDRASFHNEKVIVKLDYTDFQIVK", "length": 159, "header": "tr|A0AAF6YZH3-1|A0AAF6YZH3_BOVIN Isoform 1 of Acylphosphatase OS=Bos taurus OX=9913 GN=ACYP1 PE=3 SV=1 CANONICAL=A0AAF6YZH3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3/entry", "sequence": { "sequence": "MLSDPGVCPSLAKDGAPRCALRSFCRKIPVSALLLAGVGMLIAFLGTLGCLVPAPGLSMSMAEGDTLISVDYEIFGKVQGVFFRKYTQAEGKKLGLVGWVQNTDQGTVQGQLQGPASKVRHMQEWLETKGSPKSHIDRASFHNEKVIVKLDYTDFQIVK", "length": 159, "header": "tr|A0AAF6YZH3-1|A0AAF6YZH3_BOVIN Isoform 1 of Acylphosphatase OS=Bos taurus OX=9913 GN=ACYP1 PE=3 SV=1 CANONICAL=A0AAF6YZH3-1" }, "locus": { "chromosome": "10", "start_pos": 86318283, "end_pos": 86307517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018595.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018595.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018595.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018595.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "acylphosphatase activity", "id": "GO:0003998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003998", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZH3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14965", "name": "", "equation": "an acyl phosphate + H2O = a carboxylate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S489-1", "A0AAF6YZH3-1", "P41500-1", "P07033-1" ], "evidence": [ { "id": "14965", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14965" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S489", "gene_name": "ACYP2", "activity": [ { "ec_number": "3.6.1.7", "activity": "an acyl phosphate + H2O = a carboxylate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S489" } ] }, { "ec_number": "3.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9S489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S489" } ] } ] }, { "uniprot_ac": "A0AAF6YZH3", "gene_name": "ACYP1", "activity": [ { "ec_number": "3.6.1.7", "activity": "an acyl phosphate + H2O = a carboxylate + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YZH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3" } ] }, { "ec_number": "3.6.1.7", "activity": "", "evidence": [ { "id": "A0AAF6YZH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3" } ] } ] }, { "uniprot_ac": "P07033", "gene_name": "ACYP2", "activity": [ { "ec_number": "3.6.1.7", "activity": "an acyl phosphate + H2O = a carboxylate + phosphate + H(+).", "evidence": [ { "id": "P07033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07033" } ] }, { "ec_number": "3.6.1.7", "activity": "", "evidence": [ { "id": "P07033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07033" } ] } ] }, { "uniprot_ac": "P41500", "gene_name": "ACYP1", "activity": [ { "ec_number": "3.6.1.7", "activity": "an acyl phosphate + H2O = a carboxylate + phosphate + H(+).", "evidence": [ { "id": "P41500", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41500" } ] }, { "ec_number": "3.6.1.7", "activity": "", "evidence": [ { "id": "P41500", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41500" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YZH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZH3" }, { "id": "PS51160", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51160" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acylphosphatase-like", "eco_id": "ECO_0000259", "start_pos": 69, "end_pos": 159, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.7", "ec_name": "an acyl phosphate + H2O = a carboxylate + phosphate + H(+).", "evidence": [ { "id": "3.6.1.7", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.7" }, { "id": "3.6.1.7", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.7" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZK4-1", "uniprot_ac": "A0AAF6YZK4", "uniprot_id": "A0AAF6YZK4_BOVIN", "mass": { "chemical_mass": 26919.0, "monoisotopic_mass": 26919.0 }, "refseq": { "ac": "XP_024842084", "name": "signal peptidase complex subunit 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842084" }, "gene_names": [ { "name": "SPCS3", "type": "recommended", "evidence": [ { "id": "A0AAF6YZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4" } ] }, { "name": "SPC22/23", "type": "synonym", "evidence": [ { "id": "XP_024842084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842084" } ] }, { "name": "SPCS3", "type": "synonym", "evidence": [ { "id": "XP_024842084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842084" } ] } ], "protein_names": [ { "name": "Signal peptidase complex subunit 3", "type": "recommended", "evidence": [ { "id": "A0AAF6YZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4/entry#names_and_taxonomy" } ] }, { "name": "Microsomal signal peptidase 22/23 kDa subunit", "type": "synonym", "evidence": [ { "id": "A0AAF6YZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4/entry#names_and_taxonomy" } ] }, { "name": "signal peptidase complex subunit 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024842084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842084" } ] } ], "function": [ { "annotation": "Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4#function" }, { "database": "UniProtKB", "id": "ARBA00046080", "url": "https://www.uniprot.org/uniprotkb/ARBA00046080#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPCS3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4", "locus": { "chromosome": "27", "start_pos": 7782843, "end_pos": 7777144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014146", "url": "https://www.ensembl.org/id/ENSBTAG00000014146" } ] } } ], "crossref": [ { "id": "A0AAF6YZK4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZK4", "database": "AlphaFoldDB", "categories": [] }, { "id": "767917", "url": "https://www.ncbi.nlm.nih.gov/gene/767917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12804", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12804", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12804:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12804:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04573", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04573", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842084", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842084", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGLGVGGSAGLRGPLTSSRRPQAGGSAPGATLRRAFAGSLFSFLVERCSGRRPPFLPVPHFRARARPMREPHDSAARPPPPGLVPLTRQVSAPLDPRPFTSPGSACSYSRRRKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY", "length": 245, "header": "tr|A0AAF6YZK4-1|A0AAF6YZK4_BOVIN Isoform 1 of Signal peptidase complex subunit 3 OS=Bos taurus OX=9913 GN=SPCS3 PE=3 SV=1 CANONICAL=A0AAF6YZK4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4/entry", "sequence": { "sequence": "MGGLGVGGSAGLRGPLTSSRRPQAGGSAPGATLRRAFAGSLFSFLVERCSGRRPPFLPVPHFRARARPMREPHDSAARPPPPGLVPLTRQVSAPLDPRPFTSPGSACSYSRRRKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY", "length": 245, "header": "tr|A0AAF6YZK4-1|A0AAF6YZK4_BOVIN Isoform 1 of Signal peptidase complex subunit 3 OS=Bos taurus OX=9913 GN=SPCS3 PE=3 SV=1 CANONICAL=A0AAF6YZK4-1" }, "locus": { "chromosome": "27", "start_pos": 7782780, "end_pos": 7777343, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018803.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018803.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018803.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018803.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "viral protein processing", "id": "GO:0019082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019082", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4" } ], "pmid": "" }, { "name": "signal peptide processing", "id": "GO:0006465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006465", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "signal peptidase complex", "id": "GO:0005787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZQ8-1", "uniprot_ac": "A0AAF6YZQ8", "uniprot_id": "A0AAF6YZQ8_BOVIN", "mass": { "chemical_mass": 36549.0, "monoisotopic_mass": 36549.0 }, "refseq": { "ac": "XP_024851719", "name": "insulin-like growth factor-binding protein-like 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851719" }, "gene_names": [ { "name": "IGFBPL1", "type": "recommended", "evidence": [ { "id": "A0AAF6YZQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" } ] }, { "name": "IGFBPL1", "type": "synonym", "evidence": [ { "id": "XP_024851719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851719" } ] } ], "protein_names": [ { "name": "Insulin like growth factor binding protein like 1", "type": "synonym", "evidence": [ { "id": "A0AAF6YZQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8/entry#names_and_taxonomy" } ] }, { "name": "insulin-like growth factor-binding protein-like 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024851719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851719" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGFBPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8", "locus": { "chromosome": "8", "start_pos": 62441827, "end_pos": 62459014, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014078", "url": "https://www.ensembl.org/id/ENSBTAG00000014078" } ] } } ], "crossref": [ { "id": "A0AAF6YZQ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZQ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616886", "url": "https://www.ncbi.nlm.nih.gov/gene/616886", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14186", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14186", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14186:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14186:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00219", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00219", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YZQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVEERISEHSSISEPRPGHQPTRCASLSRAADCWRPAVQARPISGRGAGGVAAQRAQREARSRGTSAVRERTMPRSPGLFLLLLVLQPLPALGLGLRSAGGRNPECGPCRPERCPEPVRCPVPGIVARDECGCCALCLGAEGASCGGRAGARCGPGLVCASRAAGAAPEGTGLCVCAQRGSVCGSDGRSYPSVCALRLRARQAPRALPGHLHKARDGPCEFAPVVITPPQSVHNVTGAQVYLSCEVRAVPTPVVTWRKVTRSPEGTQVMEELPGDHTNIAVQVQGGPSDHEATAWVLINPLRKEDEGVYQCHSANAVGEAQSHGTVTVVDRSQYRAPRFPAPDDRL", "length": 347, "header": "tr|A0AAF6YZQ8-1|A0AAF6YZQ8_BOVIN Isoform 1 of Insulin like growth factor binding protein like 1 OS=Bos taurus OX=9913 GN=IGFBPL1 PE=4 SV=1 CANONICAL=A0AAF6YZQ8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8/entry", "sequence": { "sequence": "MVVEERISEHSSISEPRPGHQPTRCASLSRAADCWRPAVQARPISGRGAGGVAAQRAQREARSRGTSAVRERTMPRSPGLFLLLLVLQPLPALGLGLRSAGGRNPECGPCRPERCPEPVRCPVPGIVARDECGCCALCLGAEGASCGGRAGARCGPGLVCASRAAGAAPEGTGLCVCAQRGSVCGSDGRSYPSVCALRLRARQAPRALPGHLHKARDGPCEFAPVVITPPQSVHNVTGAQVYLSCEVRAVPTPVVTWRKVTRSPEGTQVMEELPGDHTNIAVQVQGGPSDHEATAWVLINPLRKEDEGVYQCHSANAVGEAQSHGTVTVVDRSQYRAPRFPAPDDRL", "length": 347, "header": "tr|A0AAF6YZQ8-1|A0AAF6YZQ8_BOVIN Isoform 1 of Insulin like growth factor binding protein like 1 OS=Bos taurus OX=9913 GN=IGFBPL1 PE=4 SV=1 CANONICAL=A0AAF6YZQ8-1" }, "locus": { "chromosome": "8", "start_pos": 62458936, "end_pos": 62445398, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018719.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018719.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018719.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018719.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of cell growth", "id": "GO:0001558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001558", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "insulin-like growth factor binding", "id": "GO:0005520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YZQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" }, { "id": "PS51323", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IGFBP N-terminal", "eco_id": "ECO_0000259", "start_pos": 103, "end_pos": 178, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YZQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 224, "end_pos": 328, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6YZQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ8" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 222, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZS2-1", "uniprot_ac": "A0AAF6YZS2", "uniprot_id": "A0AAF6YZS2_BOVIN", "mass": { "chemical_mass": 45751.0, "monoisotopic_mass": 45751.0 }, "refseq": {}, "gene_names": [ { "name": "PRKAR2A", "type": "recommended", "evidence": [ { "id": "A0AAF6YZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ] } ], "protein_names": [ { "name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "type": "recommended", "evidence": [ { "id": "A0AAF6YZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2#function" }, { "database": "UniProtKB", "id": "ARBA00037198", "url": "https://www.uniprot.org/uniprotkb/ARBA00037198#function" }, { "database": "UniProtKB", "id": "A0ABI0NQ40", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ40#function" }, { "database": "UniProtKB", "id": "A0ABI0NYD6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYD6#function" }, { "database": "UniProtKB", "id": "A0ABI0P279", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P279#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRKAR2A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2", "locus": { "chromosome": "22", "start_pos": 51155609, "end_pos": 51085601, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014205", "url": "https://www.ensembl.org/id/ENSBTAG00000014205" } ] } } ], "crossref": [ { "id": "A0AAF6YZS2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12103", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12103", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11635", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11635", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11635:SF153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11635:SF153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02197", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02197", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ40", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ40-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYD6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYD6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P279", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P279", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P279-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P279-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHIQIPPGLTELLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAAPPSGSQDFDPGAGLVADAVADSESEDEEDLDVPIPGRFDRRVSVCAETYNPDEEEEDTDPRVRTTAKVIHPKTDQQRCRLQEACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIESGEVSILIKSKTKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSMDLIDPGQ", "length": 407, "header": "tr|A0AAF6YZS2-1|A0AAF6YZS2_BOVIN Isoform 1 of cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Bos taurus OX=9913 GN=PRKAR2A PE=3 SV=1 CANONICAL=A0AAF6YZS2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2/entry", "sequence": { "sequence": "MSHIQIPPGLTELLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAAPPSGSQDFDPGAGLVADAVADSESEDEEDLDVPIPGRFDRRVSVCAETYNPDEEEEDTDPRVRTTAKVIHPKTDQQRCRLQEACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIESGEVSILIKSKTKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSMDLIDPGQ", "length": 407, "header": "tr|A0AAF6YZS2-1|A0AAF6YZS2_BOVIN Isoform 1 of cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Bos taurus OX=9913 GN=PRKAR2A PE=3 SV=1 CANONICAL=A0AAF6YZS2-1" }, "locus": { "chromosome": "22", "start_pos": 51155556, "end_pos": 51085895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018886.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018886.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018886.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018886.6" } ] } }, { "isoform_ac": "A0ABI0NQ40-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ40/entry", "sequence": { "sequence": "MSHIQIPPGLTELLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAASFRLPGFDPGAGLVADAVADSESEDEEDLDVPIPGRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIESGEVSILIKSKTKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSMDLIDPGQ", "length": 400, "header": "tr|A0ABI0NQ40-1|A0ABI0NQ40_BOVIN Computationally mapped isoform of cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Bos taurus OX=9913 GN=PRKAR2A PE=3 SV=1 CANONICAL=A0AAF6YZS2-1" }, "locus": { "chromosome": "22", "start_pos": 51155556, "end_pos": 51085895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151842.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151842.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104262.1" } ] } }, { "isoform_ac": "A0ABI0NYD6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYD6/entry", "sequence": { "sequence": "MSHIQIPPGLTELLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAASFRLPGFDPGAGLVADAVADSESEDEEDLDVPIPGRFDRRVSVCAETYNPDEEEEDTDPRVIHPKTDQQRCRLQEACKDILLFKNLDPEQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQTKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSMDLIDPGQ", "length": 378, "header": "tr|A0ABI0NYD6-1|A0ABI0NYD6_BOVIN Computationally mapped isoform of cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Bos taurus OX=9913 GN=PRKAR2A PE=3 SV=1 CANONICAL=A0AAF6YZS2-1" }, "locus": { "chromosome": "22", "start_pos": 51155556, "end_pos": 51085895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145997.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145997.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106430.1" } ] } }, { "isoform_ac": "A0ABI0P279-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P279/entry", "sequence": { "sequence": "MSHIQIPPGLTELLQGYTVEVLRQRPPDLVDFAVDYFTRLREARSRASTPPAASFRLPGFDPGAGLVADAVADSESEDEEDLDVPIPGRFDRRVSVCAETYNPDEEEEDTDPREQLSQVLDAMFERTVKVDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNHGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKVYKDGERIITQGEKADSFYIIESGEVSILIKSKTKVNKDGENQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSMDLIDPGQ", "length": 372, "header": "tr|A0ABI0P279-1|A0ABI0P279_BOVIN Computationally mapped isoform of cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Bos taurus OX=9913 GN=PRKAR2A PE=3 SV=1 CANONICAL=A0AAF6YZS2-1" }, "locus": { "chromosome": "22", "start_pos": 51155556, "end_pos": 51085895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148448.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148448.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104615.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104615.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "protein kinase A catalytic subunit binding", "id": "GO:0034236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034236", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase inhibitor activity", "id": "GO:0004862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004862", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "cAMP binding", "id": "GO:0030552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030552", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase regulator activity", "id": "GO:0008603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008603", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "plasma membrane raft", "id": "GO:0044853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044853", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "nucleotide-activated protein kinase complex", "id": "GO:0031588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031588", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase complex", "id": "GO:0005952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005952", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of cAMP/PKA signal transduction", "id": "GO:0141162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141162", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZS2" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 142, "end_pos": 261, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 384, "end_pos": 386 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM74-1", "uniprot_ac": "A0AAF6DM74", "uniprot_id": "A0AAF6DM74_BOVIN", "mass": { "chemical_mass": 21832.0, "monoisotopic_mass": 21832.0 }, "refseq": {}, "gene_names": [ { "name": "PRRG2", "type": "recommended", "evidence": [ { "id": "A0AAF6DM74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74" } ] } ], "protein_names": [ { "name": "Proline rich and Gla domain 2", "type": "synonym", "evidence": [ { "id": "A0AAF6DM74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM74", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRRG2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74", "locus": { "chromosome": "18", "start_pos": 56008382, "end_pos": 56002205, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030563", "url": "https://www.ensembl.org/id/ENSBTAG00000030563" } ] } } ], "crossref": [ { "id": "A0AAF6DM74", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM74", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24278", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24278", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24278:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24278:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6DM74", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GAAPLCCCYTWDWPPAWTLHPVGSKAEVFLDSPEAQSFLGSRKRVPRANYWDLELFTPGNLERECLEEICSWEEAREYFEDNILTDRFWESYIYNGKGGRGRVDVASLAVGLTVGVVLIILAGLGAFWYLHGRRGRRQRSCPQDVELIRPLSDLSPQTPQPPPPPPGLPTYEQALAASGVHDAPPPPYTSLRRHS", "length": 195, "header": "tr|A0AAF6DM74-1|A0AAF6DM74_BOVIN Isoform 1 of Proline rich and Gla domain 2 OS=Bos taurus OX=9913 GN=PRRG2 PE=4 SV=1 CANONICAL=A0AAF6DM74-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74/entry", "sequence": { "sequence": "GAAPLCCCYTWDWPPAWTLHPVGSKAEVFLDSPEAQSFLGSRKRVPRANYWDLELFTPGNLERECLEEICSWEEAREYFEDNILTDRFWESYIYNGKGGRGRVDVASLAVGLTVGVVLIILAGLGAFWYLHGRRGRRQRSCPQDVELIRPLSDLSPQTPQPPPPPPGLPTYEQALAASGVHDAPPPPYTSLRRHS", "length": 195, "header": "tr|A0AAF6DM74-1|A0AAF6DM74_BOVIN Isoform 1 of Proline rich and Gla domain 2 OS=Bos taurus OX=9913 GN=PRRG2 PE=4 SV=1 CANONICAL=A0AAF6DM74-1" }, "locus": { "chromosome": "18", "start_pos": 56007838, "end_pos": 56003809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019218.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019218.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019218.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019218.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM74", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM74", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM74", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM74" }, { "id": "PS50998", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50998" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Gla", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 94, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM78-1", "uniprot_ac": "A0AAF6DM78", "uniprot_id": "A0AAF6DM78_BOVIN", "mass": { "chemical_mass": 70014.0, "monoisotopic_mass": 70014.0 }, "refseq": {}, "gene_names": [ { "name": "ENG", "type": "recommended", "evidence": [ { "id": "A0AAF6DM78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ] } ], "protein_names": [ { "name": "Endoglin", "type": "synonym", "evidence": [ { "id": "A0AAF6DM78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ENG", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78", "locus": { "chromosome": "11", "start_pos": 98497641, "end_pos": 98529460, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008997", "url": "https://www.ensembl.org/id/ENSBTAG00000008997" } ] } } ], "crossref": [ { "id": "A0AAF6DM78", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM78", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR055356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26060", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26060", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RVR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRGVLCQAMALLLVVCSLGPTSLAETVYCDLQPVDSEVTYVTSQVSEGCVAQIPDATLEVHVLFLTFLGDVSRLELTLQTSKQGGIRPREVLLILSVNKSIFLKLQAPGIPLQLAYDSKLVFHEALDANITQLPSFTTKDQLLNWANTQGSIASVAELSNPQSIFLRLDQASSSPFSCNLEPQKDMGHTLGWPRAWGCRLEGVAGHKEAHILRILPGPEASPRTVTVKLELSCAWRDTDAAVLILQGPPYVSWLIEANHNMQIWTTGEYSLKIFPDRINPGFQLPNTTQGLLGEARRLNASVVASFVELPVANDVSLRTHSCGSGLQPSPTPVEITTPNKGCNQELLLTLIQPKCSSDGMTLVLKKDLISTLLCTIKSLTFGDSSCQAKETEDEFVLSSGYSSCGMEVMENVVSNEVVIRLLSSSSPQRKKVQCINTDSLSLQLGLYLSPHFLQASDTIELGQQGFVQVSVSPSIPELMIQLESCQLNLGPDMEIVELIQGQEAKSSCVSLLSPSPSGDIRFSFLLRGYMVPMPTTGILSCSVTMHPRIRSLEVHKTVSTRLNIISTSLHGGADKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRHPGKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA", "length": 649, "header": "tr|A0AAF6DM78-1|A0AAF6DM78_BOVIN Isoform 1 of Endoglin OS=Bos taurus OX=9913 GN=ENG PE=4 SV=1 CANONICAL=A0AAF6DM78-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVR6/entry", "sequence": { "sequence": "MVQRENRPGLCLEPLLEEAEDVSRLELTLQTSKQGGIRPREVLLILSVNKSIFLKLQAPGIPLQLAYDSKLVFHEALDANITQLPSFTTKDQLLNWANTQGSIASVAELSNPQSIFLRLDQASSSPFSCNLEPQKDMGHTLGWTPKAWGCRLEGVAGHKEAHILRILPGPEASPRTVTVKLELSCAWRDTDAAVLILQGPPYVSWLIEANHNMQIWTTGEYSLKIFPDRINPGFQLPNTTQGLLGEARRLNASVVASFVELPVANDVSLRTHSCGSGLQPSPTPVEITTPNKGCNQELLLTLIQPKCSSDGMTLVLKKDLISTLLCTIKSLTFGDSSCQAKETEDEFVLSSGYSSCGMEVMENVVSNEVVIRLLSSSSPQRKKVQCINTDSLSLQLGLYLSPHFLQASDTIELGQQGFVQVSVSPSIPELMIQLESCQLNLGPDMEIVELIQGQEAKSSCVSLLSPSPSGDIRFSFLLRGYMVPMPTTGILSCSVTMHPRIRSLEVHKTVSTRLNIISTSLHDKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRHPGKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA", "length": 597, "header": "tr|A0AAA9RVR6-1|A0AAF6DM78_BOVIN Computationally mapped isoform of Endoglin OS=Bos taurus OX=9913 GN=ENG PE=4 SV=1 CANONICAL=A0AAF6DM78-1" }, "locus": { "chromosome": "11", "start_pos": 98516682, "end_pos": 98498293, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103952.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103952.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076437.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076437.1" } ] } }, { "isoform_ac": "A0AAF6DM78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78/entry", "sequence": { "sequence": "MDRGVLCQAMALLLVVCSLGPTSLAETVYCDLQPVDSEVTYVTSQVSEGCVAQIPDATLEVHVLFLTFLGDVSRLELTLQTSKQGGIRPREVLLILSVNKSIFLKLQAPGIPLQLAYDSKLVFHEALDANITQLPSFTTKDQLLNWANTQGSIASVAELSNPQSIFLRLDQASSSPFSCNLEPQKDMGHTLGWPRAWGCRLEGVAGHKEAHILRILPGPEASPRTVTVKLELSCAWRDTDAAVLILQGPPYVSWLIEANHNMQIWTTGEYSLKIFPDRINPGFQLPNTTQGLLGEARRLNASVVASFVELPVANDVSLRTHSCGSGLQPSPTPVEITTPNKGCNQELLLTLIQPKCSSDGMTLVLKKDLISTLLCTIKSLTFGDSSCQAKETEDEFVLSSGYSSCGMEVMENVVSNEVVIRLLSSSSPQRKKVQCINTDSLSLQLGLYLSPHFLQASDTIELGQQGFVQVSVSPSIPELMIQLESCQLNLGPDMEIVELIQGQEAKSSCVSLLSPSPSGDIRFSFLLRGYMVPMPTTGILSCSVTMHPRIRSLEVHKTVSTRLNIISTSLHGGADKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRHPGKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA", "length": 649, "header": "tr|A0AAF6DM78-1|A0AAF6DM78_BOVIN Isoform 1 of Endoglin OS=Bos taurus OX=9913 GN=ENG PE=4 SV=1 CANONICAL=A0AAF6DM78-1" }, "locus": { "chromosome": "11", "start_pos": 98529302, "end_pos": 98498293, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011846.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011846.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011846.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011846.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 332, "start_aa": "Thr", "end_pos": 332, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr332", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 536, "start_aa": "Thr", "end_pos": 536, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr536", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "endothelial microparticle", "id": "GO:0072563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072563", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 22, "go_terms": [ { "name": "regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0017015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017015", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "positive regulation of BMP signaling pathway", "id": "GO:0030513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030513", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "dorsal aorta morphogenesis", "id": "GO:0035912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035912", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation", "id": "GO:1905007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905007", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell development", "id": "GO:0097084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097084", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "epithelial to mesenchymal transition involved in endocardial cushion formation", "id": "GO:0003198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "positive regulation of vascular associated smooth muscle cell differentiation", "id": "GO:1905065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905065", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "atrioventricular canal morphogenesis", "id": "GO:1905222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905222", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "positive regulation of SMAD protein signal transduction", "id": "GO:0060391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060391", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "outflow tract septum morphogenesis", "id": "GO:0003148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003148", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "ventricular trabecula myocardium morphogenesis", "id": "GO:0003222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003222", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "smooth muscle tissue development", "id": "GO:0048745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048745", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "atrial cardiac muscle tissue morphogenesis", "id": "GO:0055009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055009", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "venous blood vessel morphogenesis", "id": "GO:0048845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048845", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "central nervous system vasculogenesis", "id": "GO:0022009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022009", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "signaling receptor activator activity", "id": "GO:0030546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030546", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "transforming growth factor beta binding", "id": "GO:0050431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050431", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "type II transforming growth factor beta receptor binding", "id": "GO:0005114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005114", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "glycosaminoglycan binding", "id": "GO:0005539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005539", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "type I transforming growth factor beta receptor binding", "id": "GO:0034713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034713", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "BMP binding", "id": "GO:0036122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" }, { "name": "galactose binding", "id": "GO:0005534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005534", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6DM78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" }, { "id": "PF26060", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26060" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TGFBR3/Endoglin-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 193, "start_aa": "Thr", "end_aa": "Trp", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6DM78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM78" }, { "id": "PF23344", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23344" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZP-N", "eco_id": "ECO_0000259", "start_pos": 356, "end_pos": 428, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 332, 536 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 632, "end_pos": 634 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6DM35-1", "uniprot_ac": "A0AAF6DM35", "uniprot_id": "A0AAF6DM35_BOVIN", "mass": { "chemical_mass": 43128.0, "monoisotopic_mass": 43128.0 }, "refseq": { "ac": "NP_001422177", "name": "cell cycle checkpoint control protein RAD9A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177" }, "gene_names": [ { "name": "RAD9A", "type": "recommended", "evidence": [ { "id": "A0AAF6DM35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ] }, { "name": "RAD9A", "type": "synonym", "evidence": [ { "id": "NP_001422177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177" } ] } ], "protein_names": [ { "name": "Cell cycle checkpoint control protein", "type": "recommended", "evidence": [ { "id": "A0AAF6DM35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35/entry#names_and_taxonomy" } ] }, { "name": "RAD9 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001422177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177" } ] }, { "name": "cell cycle checkpoint control protein RAD9A", "type": "synonym", "evidence": [ { "id": "NP_001422177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177" } ] } ], "function": [ { "annotation": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3S5ZPW0", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPW0#function" }, { "database": "UniProtKB", "id": "ARBA00059283", "url": "https://www.uniprot.org/uniprotkb/ARBA00059283#function" }, { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35#function" } ] }, { "annotation": "MiR-2425-5p targets RAD9A and MYOG to regulate the proliferation and differentiation of bovine skeletal muscle-derived satellite cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001422177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177" }, { "database": "PubMed", "id": "28341832", "url": "https://glygen.org/publication/PubMed/28341832" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAD9A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35", "locus": { "chromosome": "29", "start_pos": 45292641, "end_pos": 45286731, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012141", "url": "https://www.ensembl.org/id/ENSBTAG00000012141" } ] } } ], "crossref": [ { "id": "A0AAF6DM35", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6DM35", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012141", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012141", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00577", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00577", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504647", "url": "https://www.ncbi.nlm.nih.gov/gene/504647", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NETQCRF", "url": "https://omabrowser.org/oma/group/NETQCRF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPW0", "url": "https://www.orthodb.org/?gene=A0A3S5ZPW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15237", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15237", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15237:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15237:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04139", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04139", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-176187", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5685938", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685938", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5693607", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69473", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001422177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPW0", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCLVTGSNVKVLGKAVHSLSRIGDELYLEPLEDGLSLRTVNSSRSAYACFLFAPLFFQQYQAATPGQDQLRCKILMKSFLSVFRSLAMLEKTVEKCCISLNDRSSRLVVQLHCKYGVRKTHNLSFQDCESLQAVFDPALCPHVLRAPARVLVEAVLPFPPALAEVTLGIGHGRRVILRSYQEEEADSAIKAMVTEMSIGEEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLSLSIHFDAPGRPAIFAIEDSLLDGHFVLATLSESDSHPQTLHAQEELQRPEPGPQAHSTPHLDLDDFAVDDMDSYMIAMETTTGSEGSRALPSISLSPGLQRPCSSSPHSEEEDDDMEPSTVPGTPPPKKFRSLFFGSILAPAHSPQGPSPVLAEDSEGEG", "length": 395, "header": "tr|A0AAF6DM35-1|A0AAF6DM35_BOVIN Isoform 1 of Cell cycle checkpoint control protein OS=Bos taurus OX=9913 GN=RAD9A PE=3 SV=1 CANONICAL=A0AAF6DM35-1" }, "isoforms": [ { "isoform_ac": "A0A3S5ZPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPW0/entry", "sequence": { "sequence": "MKCLVTGSNVKVLGKAVHSLSRIGDELYLEPLEDGLSLRTVNSSRSAYACFLFAPLFFQQYQAATPGQDQLRCKILMKSFLSVFRSLAMLEKTVEKCCISLNDRSSRLVVQLHCKYGVRKTHNLSFQDCESLQAVFDPALCPHVLRAPARVLVEAVLPFPPALAEVTLGIGHGRRVILRSYQEEEAEPGFLLLLSPPDSAIKAMVTEMSIGEEDFQQLQAQEGVAITFCLKEFRVRFLPCTHCPVHLSSLPSLHALLLPCQGLLSFAESANLSLSIHFDAPGRPAIFAIEDSLLDGHFVLATLSESDSHPQTLHAQEELQRPEPGPQAHSTPHLDLDDFAVDDMDSYMIAMETTTGSEGSRALPSISLSPGLQRPCSSSPHSEEEDDDMEPSTVPGTPPPKKFRSLFFGSILAPAHSPQGPSPVLAEDSEGEG", "length": 433, "header": "tr|A0A3S5ZPW0-1|A0A3S5ZPW0_BOVIN Computationally mapped isoform of Cell cycle checkpoint control protein OS=Bos taurus OX=9913 GN=RAD9A PE=3 SV=2 CANONICAL=A0AAF6DM35-1" }, "locus": { "chromosome": "29", "start_pos": 45291813, "end_pos": 45286833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016108.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016108.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016108.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016108.7" } ] } }, { "isoform_ac": "A0AAF6DM35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35/entry", "sequence": { "sequence": "MKCLVTGSNVKVLGKAVHSLSRIGDELYLEPLEDGLSLRTVNSSRSAYACFLFAPLFFQQYQAATPGQDQLRCKILMKSFLSVFRSLAMLEKTVEKCCISLNDRSSRLVVQLHCKYGVRKTHNLSFQDCESLQAVFDPALCPHVLRAPARVLVEAVLPFPPALAEVTLGIGHGRRVILRSYQEEEADSAIKAMVTEMSIGEEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLSLSIHFDAPGRPAIFAIEDSLLDGHFVLATLSESDSHPQTLHAQEELQRPEPGPQAHSTPHLDLDDFAVDDMDSYMIAMETTTGSEGSRALPSISLSPGLQRPCSSSPHSEEEDDDMEPSTVPGTPPPKKFRSLFFGSILAPAHSPQGPSPVLAEDSEGEG", "length": 395, "header": "tr|A0AAF6DM35-1|A0AAF6DM35_BOVIN Isoform 1 of Cell cycle checkpoint control protein OS=Bos taurus OX=9913 GN=RAD9A PE=3 SV=1 CANONICAL=A0AAF6DM35-1" }, "locus": { "chromosome": "29", "start_pos": 45291813, "end_pos": 45286833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044769.6", "url": "https://www.ensembl.org/id/ENSBTAT00000044769.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042235.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042235.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 65, "start_aa": "Thr", "end_pos": 65, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr65", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "MiR-2425-5p targets RAD9A and MYOG to regulate the proliferation and differentiation of bovine skeletal muscle-derived satellite cells.", "journal": "Scientific reports", "date": "2017-03-24", "authors": "Tong Hui Li, Jiang Run Ying, Zhang Wei Wei, Yan Yun Qin", "evidence": [ { "database": "RefSeq", "id": "NP_001422177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422177" } ], "reference": [ { "type": "PubMed", "id": "28341832", "url": "https://glygen.org/publication/PubMed/28341832" } ] } ], "pathway": [ { "id": "R-BTA-176187", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "resource": "Reactome", "description": "Activation of ATR in response to replication stress" }, { "id": "R-BTA-5685938", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685938", "resource": "Reactome", "description": "HDR through Single Strand Annealing (SSA)" }, { "id": "R-BTA-5693607", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "resource": "Reactome", "description": "Processing of DNA double-strand break ends" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" }, { "id": "R-BTA-69473", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "resource": "Reactome", "description": "G2/M DNA damage checkpoint" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXM2-1", "protein_name": "Cell cycle checkpoint control protein", "gene_name": "Rad9a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFAPLFFQQYQEASPGQDLLRCKILMKSFLSVFRSLATVEKTVEKCCISLSGSNSHLVVQLHCKYGVKKTHNLSFQDCESLQAVFDPASCPHLLRTPARVLAEAVLSFPLALTEVTLGIGRGRRVILRSYQEEEADSTSKAMVTETSIGEEDFQQLHAPEGRAVTFCLKEFRGLLSFAESANLPLTIHFDVPGRPVIFTVEDSLLDAHFVLATLLEQDSCSQDLCSPKPHQPVPQKQPHSTPHSDDFTNDDIDCYMIAMETTVGNESSRAQPSTSLPPVPQASHDLAPPSEEEEEEAEPSTVPGTPPPKKFRSLFFGSILAPIHSPQGPNPVLAEDSDGEG", "length": 392 }, "evidence": [ { "id": "A0AAF6DM35", "url": "https://omabrowser.org/oma/group/A0AAF6DM35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F2Z4U5-1", "protein_name": "Cell cycle checkpoint control protein", "gene_name": "rad9a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDCVATGANVKVLAKAIHSLSRIGEELYLEPVDDGLALRSVNSSRSAFASFQLSPLFFQRYQAPTDQSFRCKMPIKSVQAVFKSLSSLERSVEKCRIQLNSEKSRLTITLHCKHGLLKTHNLSFQDCESLQAVFDKESCTNVLQAQPRLMVDTVLHFPPSLEEVNLSVSSDRVWLRNHVEDDADSSRAMMTELCLSSEEFDHFAISSQTSITFCLKELRGLLGFAESSCLPISMYFDEPGSPVILNVTDSVLEANFVLATLSEDSHSKNHVNSNTKRPDAEQPPDDFMSDDMDSFLIAMETSELPGPSHVPTSPLQPINNRKHSASDDEEEEALAERPPNKKFCSLFFGSVLPTPSLTNQTIQSQEVLASDSEDENQTETS", "length": 381 }, "evidence": [ { "id": "A0AAF6DM35", "url": "https://omabrowser.org/oma/group/A0AAF6DM35/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3I404-1", "protein_name": "Cell cycle checkpoint control protein", "gene_name": "Rad9a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFVPLFFQQYQAASPGQDLLRCKILMKSFLSVFRSLAMVEKTVEKCCISLSSSNSHLVVQLHCKYGVKKTHNLSFQDCESLQAVFNPALCPHLLRAPARVLAEAVLSFPPALTEVTLGIGHGRRVILRSYQEEEADSTNKAMVTETSIGEEDFQQLHAPEGIAVTFCLKEFRGLLSFAESANLPLTVHFDVPGRPVIFTIEDSLLDSHFVLATLLEQDPCSQDLCSPNPCQPVPQKQAHSIPHLDDFTNDDIDCYMIAMETTVGSEGSRAQPSTSLPPVSQPSHDLVPPSEEEEEEAEPSTVPGTPPPKKFRSLFFGSILAPVHSPQGPSPVLAEDSDGEG", "length": 392 }, "evidence": [ { "id": "A0AAF6DM35", "url": "https://omabrowser.org/oma/group/A0AAF6DM35/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q99638-1", "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "RAD9A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKCLVTGGNVKVLGKAVHSLSRIGDELYLEPLEDGLSLRTVNSSRSAYACFLFAPLFFQQYQAATPGQDLLRCKILMKSFLSVFRSLAMLEKTVEKCCISLNGRSSRLVVQLHCKFGVRKTHNLSFQDCESLQAVFDPASCPHMLRAPARVLGEAVLPFSPALAEVTLGIGRGRRVILRSYHEEEADSTAKAMVTEMCLGEEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLNLSIHFDAPGRPAIFTIKDSLLDGHFVLATLSDTDSHSQDLGSPERHQPVPQLQAHSTPHPDDFANDDIDSYMIAMETTIGNEGSRVLPSISLSPGPQPPKSPGPHSEEEDEAEPSTVPGTPPPKKFRSLFFGSILAPVRSPQGPSPVLAEDSEGEG", "length": 391 }, "evidence": [ { "id": "A0AAF6DM35", "url": "https://omabrowser.org/oma/group/A0AAF6DM35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0F6-1", "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "Rad9a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFAPLFFQQYQAASPGQDLLRCKILMKAFLSVFRSLAIVEKSVEKCCISLSGSHSHLVVQLHCKYGVKKTHNLSFQDCESLQAVFDPASCPHLLRTPARVLAEAVLSFPLALTEVTLGIGRGRRVILRSYQEEEADSTSKAMVTETSIGDEDFQQLHAPEGIAVTFCLKEFRGLLSFAESANLPLTIHFDVPGRPVIFTIEDSLLDAHFVLATLLEQDSCSQGPCSPKPHQPVPQKQAHSTPHLDDFTSDDIDCYMIAMETTGGNEGSGAQPSTSLPPVSLASHDLAPTSEEEAEPSTVPGTPPPKKFRSLFFGSILAPVHSPQGPNPVLAEDSDGEG", "length": 389 }, "evidence": [ { "id": "A0AAF6DM35", "url": "https://omabrowser.org/oma/group/A0AAF6DM35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA replication checkpoint signaling", "id": "GO:0000076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000076", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "mitotic intra-S DNA damage checkpoint signaling", "id": "GO:0031573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031573", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "checkpoint clamp complex", "id": "GO:0030896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030896", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" }, { "name": "double-stranded DNA 3'-5' DNA exonuclease activity", "id": "GO:0008311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008311", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM35", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 65 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YRP0-1", "uniprot_ac": "A0AAF6YRP0", "uniprot_id": "A0AAF6YRP0_BOVIN", "mass": { "chemical_mass": 45953.0, "monoisotopic_mass": 45953.0 }, "refseq": {}, "gene_names": [ { "name": "IL2RG", "type": "recommended", "evidence": [ { "id": "A0AAF6YRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ] } ], "protein_names": [ { "name": "Cytokine receptor common subunit gamma", "type": "recommended", "evidence": [ { "id": "A0AAF6YRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0/entry#names_and_taxonomy" } ] }, { "name": "Interleukin-2 receptor subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAF6YRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0/entry#names_and_taxonomy" } ] }, { "name": "gammaC", "type": "synonym", "evidence": [ { "id": "A0AAF6YRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0/entry#names_and_taxonomy" } ] }, { "name": "p64", "type": "synonym", "evidence": [ { "id": "A0AAF6YRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0#function" }, { "database": "UniProtKB", "id": "ARBA00056919", "url": "https://www.uniprot.org/uniprotkb/ARBA00056919#function" }, { "database": "UniProtKB", "id": "A0AAA9T1B9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1B9#function" }, { "database": "UniProtKB", "id": "A0AAA9T5I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL2RG", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0", "locus": { "chromosome": "X", "start_pos": 79525869, "end_pos": 79521595, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007626", "url": "https://www.ensembl.org/id/ENSBTAG00000007626" } ] } } ], "crossref": [ { "id": "A0AAF6YRP0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YRP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23037:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T1B9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1B9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCGWGGVVGKGPRFLTQSTPRERRVSAMLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIGGKPGTGGDFFLTSTPAGTLDVSTLPLPKVQCFVFNVEYMNCTWNSSSEPQPNNLTLHYGYRNFNGDDKLQECGHYLFSEGITSGCWFGKKEIRLYETFVVQLQDPREHRKQPKQMLKLQDLVIPWAPENLTLRNLSEFQLELSWSNRYLDHCLEHLVQYRSDRDRSWTEQSVDHRHSFSLPSVDAQKLYTFRVRSRYNPLCGSAQHWSDWSYPIHWGSNTSKENIENPENPSLFALEAVLIPLGSMGLIVSLICVYCWLERTMPRIPTLKNLEDLVTEYQGNFSAWSGVSKGLAESLQPDYSERLCHVSEIPPKGGEGPGGSPCSQHSPYWAPPCYTLKPEP", "length": 406, "header": "tr|A0AAF6YRP0-1|A0AAF6YRP0_BOVIN Isoform 1 of Cytokine receptor common subunit gamma OS=Bos taurus OX=9913 GN=IL2RG PE=3 SV=1 CANONICAL=A0AAF6YRP0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1B9/entry", "sequence": { "sequence": "MCGWGGVVGKGPRFLTQSTPRERRVSAMLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIGGKPGTGGDFFLTSTPAGTLDVSTLPLPKVQCFVFNVEYMNCTWNSSSEPQPNNLTLHYGYRNFNGDDKLQECGHYLFSEGITSGCWFGKKEIRLYETFVVQLQDPREHRKQPKQMLKLQDLVIPWAPENLTLRNLSEFQLELSWSNRYLDHCLEHLVQYRSDRDRSWTEQSVDHRHSFSLPSVDAQKLYTFRVRSRYNPLCGSAQHWSDWSYPIHWGSNTSKENIENPENPSLFALEAVLIPLGSMGLIVSLICVYCWLERTMPRIPTLKNLEDLVTEYQGNFSPPDLMGPLGPSRPLGHPPSAMTSQDSL", "length": 375, "header": "tr|A0AAA9T1B9-1|A0AAF6YRP0_BOVIN Computationally mapped isoform of Cytokine receptor common subunit gamma OS=Bos taurus OX=9913 GN=IL2RG PE=3 SV=1 CANONICAL=A0AAF6YRP0-1" }, "locus": { "chromosome": "X", "start_pos": 79525836, "end_pos": 79521597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114533.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114533.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090378.1" } ] } }, { "isoform_ac": "A0AAA9T5I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I3/entry", "sequence": { "sequence": "MLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIDFFLTSTPAGTLDVSTLPLPKVQCFVFNVEYMNCTWNSSSEPQPNNLTLHYGYRNFNGDDKLQECGHYLFSEGITSGCWFGKKEIRLYETFVVQLQDPREHRKQPKQMLKLQDLVIPWAPENLTLRNLSEFQLELSWSNRYLDHCLEHLVQYRSDRDRSWTEQSVDHRHSFSLPSVDAQKLYTFRVRSRYNPLCGSAQHWSDWSYPIHWGSNTSKGQCPEFLLS", "length": 260, "header": "tr|A0AAA9T5I3-1|A0AAF6YRP0_BOVIN Computationally mapped isoform of Cytokine receptor common subunit gamma OS=Bos taurus OX=9913 GN=IL2RG PE=3 SV=1 CANONICAL=A0AAF6YRP0-1" }, "locus": { "chromosome": "X", "start_pos": 79524456, "end_pos": 79521678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090634.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090634.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094028.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094028.1" } ] } }, { "isoform_ac": "A0AAF6YRP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0/entry", "sequence": { "sequence": "MCGWGGVVGKGPRFLTQSTPRERRVSAMLKPPLPLRSLLFLQLPLLGVGLNPKFLTPSGNEDIGGKPGTGGDFFLTSTPAGTLDVSTLPLPKVQCFVFNVEYMNCTWNSSSEPQPNNLTLHYGYRNFNGDDKLQECGHYLFSEGITSGCWFGKKEIRLYETFVVQLQDPREHRKQPKQMLKLQDLVIPWAPENLTLRNLSEFQLELSWSNRYLDHCLEHLVQYRSDRDRSWTEQSVDHRHSFSLPSVDAQKLYTFRVRSRYNPLCGSAQHWSDWSYPIHWGSNTSKENIENPENPSLFALEAVLIPLGSMGLIVSLICVYCWLERTMPRIPTLKNLEDLVTEYQGNFSAWSGVSKGLAESLQPDYSERLCHVSEIPPKGGEGPGGSPCSQHSPYWAPPCYTLKPEP", "length": 406, "header": "tr|A0AAF6YRP0-1|A0AAF6YRP0_BOVIN Isoform 1 of Cytokine receptor common subunit gamma OS=Bos taurus OX=9913 GN=IL2RG PE=3 SV=1 CANONICAL=A0AAF6YRP0-1" }, "locus": { "chromosome": "X", "start_pos": 79524984, "end_pos": 79521597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010033.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010033.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010033.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010033.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "interleukin-2-mediated signaling pathway", "id": "GO:0038110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038110", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "cellular homeostasis", "id": "GO:0019725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019725", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis", "id": "GO:0050766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "interleukin-7-mediated signaling pathway", "id": "GO:0038111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038111", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via JAK-STAT", "id": "GO:0007259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007259", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "interleukin-9-mediated signaling pathway", "id": "GO:0038113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038113", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "interleukin-2 binding", "id": "GO:0019976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019976", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" }, { "name": "interleukin-15 receptor activity", "id": "GO:0042010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042010", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6YRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRP0" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 190, "end_pos": 287, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 108, "end_pos": 110 }, { "start_pos": 117, "end_pos": 119 }, { "start_pos": 193, "end_pos": 195 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 346, "end_pos": 348 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A7H1-1", "uniprot_ac": "A0AAF7A7H1", "uniprot_id": "A0AAF7A7H1_BOVIN", "mass": { "chemical_mass": 117425.0, "monoisotopic_mass": 117425.0 }, "refseq": {}, "gene_names": [ { "name": "MAN2B1", "type": "recommended", "evidence": [ { "id": "A0AAF7A7H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ] } ], "protein_names": [ { "name": "Alpha-mannosidase", "type": "recommended", "evidence": [ { "id": "A0AAF7A7H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.-", "type": "synonym", "evidence": [ { "id": "A0AAF7A7H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Can hydrolyze a variety of glycan substrates containing terminal alpha-mannosidic linkages. Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues on oligosaccharides generated by N-glycoprotein degradation pathways.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DI46", "url": "https://www.uniprot.org/uniprotkb/A0A452DI46#function" }, { "database": "UniProtKB", "id": "ARBA00094329", "url": "https://www.uniprot.org/uniprotkb/ARBA00094329#function" }, { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAN2B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1", "locus": { "chromosome": "7", "start_pos": 12853763, "end_pos": 12837683, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006241", "url": "https://www.ensembl.org/id/ENSBTAG00000006241" } ] } } ], "crossref": [ { "id": "A0AAF7A7H1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A7H1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006241", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006241", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10810", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10810", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028995", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028995", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI46", "url": "https://www.orthodb.org/?gene=A0A452DI46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11607", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11607", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11607:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11607:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01074", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01074", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07748", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07748", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09261", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09261", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17677", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17677", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21260", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21260", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "84975", "url": "https://www.rhea-db.org/rhea/84975", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "84979", "url": "https://www.rhea-db.org/rhea/84979", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI46", "url": "https://www.uniprot.org/uniprotkb/A0A452DI46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI46-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A7H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVVTPRARPRLCPLAKSCSGGGAFTRPQPGRGTPVGGGGGGGGCRAMVGDARPSGVRAGGCRGAVGSRTSSRALRPPLPPLSSLFVLFLAAPCAWAAGYKTCPKVKPDMLNVHLVPHTHDDVGWLKTVDQYFYGIYNNIQPAGVQYILDSVISSLLANPTRRFIYVEIAFFSRWWRQQTNATQKIVRELVRQGRLEFANGGWVMNDEATTHYGAIIDQMTLGLRFLEETFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKKVRKKTLQMEQVWRASTSLKPPTADLFTSVLPNMYNPPEGLCWDMLCADKPVVEDTRSPEYNAKELVRYFLKLATDQGKLYRTKHTVMTMGSDFQYENANTWFKNLDKLIQLVNAQQRANGIRVNVLYSTPACYLWELNKANLSWSVKKDDFFPYADGPYMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGPAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLSEGWRPCEVLMSNALAHLSGLKEDFAFCRKLNISICPLTQTAERFQVIVYNPLGRKVDWMVRLPVSKHVYLVKDPGGKIVPSDVVTIPSSDSQELLFSALVPAVGFSIYSVSQMPNQRPQKSWSRDLVIQNEYLRARFDPNTGLLMELENLEQNLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQGGGARYRLEKAPRTQFSGLRRELPPSVRLLTLARWGPETLLLRLEHQFAVGEDSGRNLSSPVTLDLTNLFSAFTITNLRETTLAANQLLAYASRLQWTTDTGPTPHPSPSRPVSATITLQPMEIRTFLASVQWEEDG", "length": 1046, "header": "tr|A0AAF7A7H1-1|A0AAF7A7H1_BOVIN Isoform 1 of Alpha-mannosidase OS=Bos taurus OX=9913 GN=MAN2B1 PE=3 SV=1 CANONICAL=A0AAF7A7H1-1" }, "isoforms": [ { "isoform_ac": "A0A452DI46-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI46/entry", "sequence": { "sequence": "MVGDARPSGVRAGGCRGAVGSRTSSRALRPPLPPLSSLFVLFLAAPCAWAAGYKTCPKVKPDMLNVHLVPHTHDDVGWLKTVDQYFYGIYNNIQPAGVQYILDSVISSLLANPTRRFIYVEIAFFSRWWRQQTNATQKIVRELVRQGRLEFANGGWVMNDEATTHYGAIIDQMTLGLRFLEETFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKKVRKKTLQMEQVWRASTSLKPPTADLFTSVLPNMYNPPEGLCWDMLCADKPVVEDTRSPEYNAKELVRYFLKLATDQGKLYRTKHTVMTMGSDFQYENANTWFKNLDKLIQLVNAQQRANGIRVNVLYSTPACYLWELNKANLSWSVKKDDFFPYADGPYMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGPAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLSEGWRPCEVLMSNALAHLSGLKEDFAFCRKLNISICPLTQTAERFQVIVYNPLGRKVDWMVRLPVSKHVYLVKDPGGKIVPSDVVTIPSSDSQELLFSALVPAVGFSIYSVSQMPNQRPQKSWSRDLVIQNEYLRARFDPNTGLLMELENLEQNLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKVRGLRVGTWGQGVSPPCHPIGYRDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQGGGARYRLEKAPRTQFSGLRRELPPSVRLLTLARWGPETLLLRLEHQFAVGEDSGRNLSSPVTLDLTNLFSAFTITNLRETTLAANQLLAYASRLQWTTDTGPTPHPSPSRPVSATITLQPMEIRTFLASVQWEEDG", "length": 982, "header": "tr|A0A452DI46-1|A0AAF7A7H1_BOVIN Computationally mapped isoform of Alpha-mannosidase OS=Bos taurus OX=9913 GN=MAN2B1 PE=3 SV=1 CANONICAL=A0AAF7A7H1-1" }, "locus": { "chromosome": "7", "start_pos": 12853642, "end_pos": 12838440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008193.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008193.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008193.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008193.5" } ] } }, { "isoform_ac": "A0AAF7A7H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1/entry", "sequence": { "sequence": "MDVVTPRARPRLCPLAKSCSGGGAFTRPQPGRGTPVGGGGGGGGCRAMVGDARPSGVRAGGCRGAVGSRTSSRALRPPLPPLSSLFVLFLAAPCAWAAGYKTCPKVKPDMLNVHLVPHTHDDVGWLKTVDQYFYGIYNNIQPAGVQYILDSVISSLLANPTRRFIYVEIAFFSRWWRQQTNATQKIVRELVRQGRLEFANGGWVMNDEATTHYGAIIDQMTLGLRFLEETFGSDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKKVRKKTLQMEQVWRASTSLKPPTADLFTSVLPNMYNPPEGLCWDMLCADKPVVEDTRSPEYNAKELVRYFLKLATDQGKLYRTKHTVMTMGSDFQYENANTWFKNLDKLIQLVNAQQRANGIRVNVLYSTPACYLWELNKANLSWSVKKDDFFPYADGPYMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGPAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLSEGWRPCEVLMSNALAHLSGLKEDFAFCRKLNISICPLTQTAERFQVIVYNPLGRKVDWMVRLPVSKHVYLVKDPGGKIVPSDVVTIPSSDSQELLFSALVPAVGFSIYSVSQMPNQRPQKSWSRDLVIQNEYLRARFDPNTGLLMELENLEQNLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQGGGARYRLEKAPRTQFSGLRRELPPSVRLLTLARWGPETLLLRLEHQFAVGEDSGRNLSSPVTLDLTNLFSAFTITNLRETTLAANQLLAYASRLQWTTDTGPTPHPSPSRPVSATITLQPMEIRTFLASVQWEEDG", "length": 1046, "header": "tr|A0AAF7A7H1-1|A0AAF7A7H1_BOVIN Isoform 1 of Alpha-mannosidase OS=Bos taurus OX=9913 GN=MAN2B1 PE=3 SV=1 CANONICAL=A0AAF7A7H1-1" }, "locus": { "chromosome": "7", "start_pos": 12853642, "end_pos": 12838299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070599.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070599.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064540.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064540.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1013, "start_aa": "Thr", "end_pos": 1013, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1013", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ], "pmid": "" }, { "name": "alpha-mannosidase activity", "id": "GO:0004559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004559", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mannose metabolic process", "id": "GO:0006013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006013", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A7H1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 681, "end_pos": 683, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 966, "end_pos": 968, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "84975", "name": "", "equation": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + H2O = alpha-D-Man-(1->6)-beta-D-Man-(1->4)-D-GlcNAc + D-mannose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29451-1", "A0AAF7A7H1-1" ], "evidence": [ { "id": "84975", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84975" } ] }, { "id": "84979", "name": "", "equation": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + H2O = alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + D-mannose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29451-1", "A0AAF7A7H1-1" ], "evidence": [ { "id": "84979", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84979" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF7A7H1", "gene_name": "MAN2B1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "A0AAF7A7H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" } ] } ] }, { "uniprot_ac": "Q29451", "gene_name": "MAN2B1", "activity": [ { "ec_number": "3.2.1.24", "activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] }, { "ec_number": "3.2.1.24", "activity": "", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7A7H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7H1" }, { "id": "SM00872", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00872" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycoside hydrolase family 38 central", "eco_id": "ECO_0000259", "start_pos": 435, "end_pos": 514, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1013 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 181, "end_pos": 183 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 546, "end_pos": 548 }, { "start_pos": 681, "end_pos": 683 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 728, "end_pos": 730 }, { "start_pos": 802, "end_pos": 804 }, { "start_pos": 966, "end_pos": 968 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8S7-1", "uniprot_ac": "A0AAF6Z8S7", "uniprot_id": "A0AAF6Z8S7_BOVIN", "mass": { "chemical_mass": 49784.0, "monoisotopic_mass": 49784.0 }, "refseq": {}, "gene_names": [ { "name": "ACP2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] } ], "protein_names": [ { "name": "Lysosomal acid phosphatase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.2", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACP2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7", "locus": { "chromosome": "15", "start_pos": 77118307, "end_pos": 77125851, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021002", "url": "https://www.ensembl.org/id/ENSBTAG00000021002" } ] } } ], "crossref": [ { "id": "A0AAF6Z8S7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8S7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07061", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07061", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11567", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11567", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11567:SF180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11567:SF180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00328", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00328", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "15017", "url": "https://www.rhea-db.org/rhea/15017", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9S0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASGLPACVLKGASGWLLQVSPRGFQPLCCIDYSGDGGQAVWLEPGSSSPAHSWCEPDGDATHPGPDSAFRYFAVPTWRPLSSESISQGPPSGRQMAPGLWSANQGGDAAALGAGPGSATALPWLPQHLLPPTRDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRLLKFPLGPCPRFEQLQNETRRMPEYQNESVQNAQFLDMVANETGLTDLSLETVWNVYDTLFCEQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTEVIVALAVCGSILFLLIVLLLTVLFRVQAQPPGYRHVPDGEDHA", "length": 453, "header": "tr|A0AAF6Z8S7-1|A0AAF6Z8S7_BOVIN Isoform 1 of Lysosomal acid phosphatase OS=Bos taurus OX=9913 GN=ACP2 PE=3 SV=1 CANONICAL=A0AAF6Z8S7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZA3/entry", "sequence": { "sequence": "MAGRRFGWSRAALLQLILGVNLMVMPRTQARTLRFVTLLYRHGDRSPVKAYPKDPHQEDKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRQFLDMVANETGLTDLSLETVWNVYDTLFCEQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTEVIVALAVCGSILFLLIVLLLTVLFRVQAQPPGYRHVPDGEDHA", "length": 390, "header": "tr|A0AAA9RZA3-1|A0AAF6Z8S7_BOVIN Computationally mapped isoform of Lysosomal acid phosphatase OS=Bos taurus OX=9913 GN=ACP2 PE=3 SV=1 CANONICAL=A0AAF6Z8S7-1" }, "locus": { "chromosome": "15", "start_pos": 77125543, "end_pos": 77119098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124179.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124179.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078926.1" } ] } }, { "isoform_ac": "A0AAA9S9S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S0/entry", "sequence": { "sequence": "MAGRRFGWSRAALLQLILGVNLMVMPRTQARTLRFVTLLYRHGDRSPVKAYPKDPHQEDKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRLLKFPLGPCPRFEQLQNETRRMPEYQNESVQNAQFLDMVANETGLTDLSLETVWNVYDTLFCEQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTGSFLYWLLLPTNQQMAPGSSAWLFPH", "length": 405, "header": "tr|A0AAA9S9S0-1|A0AAF6Z8S7_BOVIN Computationally mapped isoform of Lysosomal acid phosphatase OS=Bos taurus OX=9913 GN=ACP2 PE=3 SV=1 CANONICAL=A0AAF6Z8S7-1" }, "locus": { "chromosome": "15", "start_pos": 77125543, "end_pos": 77120209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125574.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125574.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080163.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080163.1" } ] } }, { "isoform_ac": "A0AAA9T1H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H6/entry", "sequence": { "sequence": "MAGRRFGWSRAALLQLILGVNLMVMPRTQARTLRFVTLEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRLLKFPLGPCPRFEQLQNETRRMPEYQNESVQNAQFLDMVANETGLTDLSLETVWNVYDTLFCEQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTEVIVALAVCGSILFLLIVLLLTVLFRVQAQPPGYRHVPDGEDHA", "length": 391, "header": "tr|A0AAA9T1H6-1|A0AAF6Z8S7_BOVIN Computationally mapped isoform of Lysosomal acid phosphatase OS=Bos taurus OX=9913 GN=ACP2 PE=3 SV=1 CANONICAL=A0AAF6Z8S7-1" }, "locus": { "chromosome": "15", "start_pos": 77125543, "end_pos": 77119098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119880.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119880.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091565.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091565.1" } ] } }, { "isoform_ac": "A0AAA9TAQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAQ7/entry", "sequence": { "sequence": "MAGRRFGWSRAALLQLILGVNLMVMPRTQARTLRFVTLLYRHGDRSPVKAYPKDPHQEDKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTEVIVALAVCGSILFLLIVLLLTVLFRVQAQPPGYRHVPDGEDHA", "length": 360, "header": "tr|A0AAA9TAQ7-1|A0AAF6Z8S7_BOVIN Computationally mapped isoform of Lysosomal acid phosphatase OS=Bos taurus OX=9913 GN=ACP2 PE=3 SV=1 CANONICAL=A0AAF6Z8S7-1" }, "locus": { "chromosome": "15", "start_pos": 77125543, "end_pos": 77119098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130361.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130361.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093096.1" } ] } }, { "isoform_ac": "A0AAF6Z8S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7/entry", "sequence": { "sequence": "MAASGLPACVLKGASGWLLQVSPRGFQPLCCIDYSGDGGQAVWLEPGSSSPAHSWCEPDGDATHPGPDSAFRYFAVPTWRPLSSESISQGPPSGRQMAPGLWSANQGGDAAALGAGPGSATALPWLPQHLLPPTRDFDRTLMSAEANLAGLFPPDGIQRFNPNISWQPIPVHTVPVAEDRLLKFPLGPCPRFEQLQNETRRMPEYQNESVQNAQFLDMVANETGLTDLSLETVWNVYDTLFCEQTHGLPLPPWASPQTMQRLSRLKDFSFRFLFGIYKQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALHMALGVYNGEQAPYASCHMFELYQEDSGNFSVEMYFRNESHRAPWPLTLPGCSHRCPLQDFLRLTEPVVPKDWLQECQLAGGPADTEVIVALAVCGSILFLLIVLLLTVLFRVQAQPPGYRHVPDGEDHA", "length": 453, "header": "tr|A0AAF6Z8S7-1|A0AAF6Z8S7_BOVIN Isoform 1 of Lysosomal acid phosphatase OS=Bos taurus OX=9913 GN=ACP2 PE=3 SV=1 CANONICAL=A0AAF6Z8S7-1" }, "locus": { "chromosome": "15", "start_pos": 77125652, "end_pos": 77119098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027968.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027968.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027968.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027968.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ], "pmid": "" }, { "name": "lysosomal lumen", "id": "GO:0043202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "acid phosphatase activity", "id": "GO:0003993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003993", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15017", "name": "", "equation": "a phosphate monoester + H2O = an alcohol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z8C2-1", "F1MUZ7-1", "E1B8A0-1", "A0AAF6Z8S7-1", "P09487-1", "A6H730-1", "P19111-1", "P11064-1", "A0A3Q1MCB1-1", "Q0P5F0-1", "A0A3Q1LSG5-1", "A0AAA9T5N9-1", "A0A3Q1N8V6-1", "A6H757-1" ], "evidence": [ { "id": "15017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15017" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LSG5", "gene_name": "LOC100125266", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] } ] }, { "uniprot_ac": "A0A3Q1MCB1", "gene_name": "", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A0AAF6Z8S7", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A6H757", "gene_name": "ACP6", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] } ] }, { "uniprot_ac": "E1B8A0", "gene_name": "ACP5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "E1B8A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8A0" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "E1B8A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8A0" } ] } ] }, { "uniprot_ac": "F1MUZ7", "gene_name": "ACP7", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1MUZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUZ7" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "F1MUZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUZ7" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "P19111", "gene_name": "ALPI", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P19111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19111" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P19111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19111" } ] } ] }, { "uniprot_ac": "Q0P5F0", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q0P5F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F0" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q0P5F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.2", "ec_name": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "3.1.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2" }, { "id": "3.1.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 197, "end_pos": 199 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 221, "end_pos": 223 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 361, "end_pos": 363 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZAY0-1", "uniprot_ac": "A0AAF6ZAY0", "uniprot_id": "A0AAF6ZAY0_BOVIN", "mass": { "chemical_mass": 52736.0, "monoisotopic_mass": 52736.0 }, "refseq": {}, "gene_names": [ { "name": "QPCTL", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ] } ], "protein_names": [ { "name": "Glutaminyl-peptide cyclotransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.5", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0/entry#names_and_taxonomy" } ] }, { "name": "Glutaminyl cyclase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0/entry#names_and_taxonomy" } ] }, { "name": "Glutaminyl-tRNA cyclotransferase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Responsible for the biosynthesis of pyroglutamyl peptides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Q3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Q3#function" }, { "database": "UniProtKB", "id": "ARBA00054592", "url": "https://www.uniprot.org/uniprotkb/ARBA00054592#function" }, { "database": "UniProtKB", "id": "A0AAA9SIV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "QPCTL", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0", "locus": { "chromosome": "18", "start_pos": 53263338, "end_pos": 53256378, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012176", "url": "https://www.ensembl.org/id/ENSBTAG00000012176" } ] } } ], "crossref": [ { "id": "A0AAF6ZAY0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZAY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03880", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03880", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12283", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12283", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12283:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12283:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "23652", "url": "https://www.rhea-db.org/rhea/23652", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S0B5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0B5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Q3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSVIKRFSLASPPALGRRLLLTLSLWGCATRGNQPPKLPEGKEPSPQAESPIGFTARGRADGAAALVAHWSGLFHGAGLGWALTLSAVSDPFQGQAAMPSGGRGRPRLQVGERSLLERPSPPKRRLIPRAQLLPQLLLALTVASVFYTIWRIWHSQTEELPLGRELRGPLIGSLPEARVRRVVGQLDPHRLWNTFLRPLLVVRTPGSPGNLQVRKFLEATLRTLSAGWHIELDSFTASTPVGPLDFSNVVATLDPGAARHLTLACHYDSKLFPSDSAPFVGATDSAVPCSLLLELAQALDQELGKAKERAAPMTLQLIFLDGEEALKQWGPKDSLYGSRHLAQLMESTPHGLGSTRIQAIELFMLLDLLGAPNPTFYSHFPRTARWFHRLRSIEKRLHRLNLLQSHPWEVMYFQTGEPPGSVEDDHIPFLRRGTCYGNWGTGGPQEFPCSTSSPHPSPLSGTRPMTPRPTCTHPRYTT", "length": 479, "header": "tr|A0AAF6ZAY0-1|A0AAF6ZAY0_BOVIN Isoform 1 of Glutaminyl-peptide cyclotransferase OS=Bos taurus OX=9913 GN=QPCTL PE=3 SV=1 CANONICAL=A0AAF6ZAY0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0B5/entry", "sequence": { "sequence": "MPSGGRGRPRLQVGERSLLERPSPPKRRLIPRAQLLPQLLLALTVASVFYTIWRIWHSQTEELPLGRELRGPLIGSLPEARVRRVVGQLDPHRLWNTFLRPLLVVRTPGSPGNLQVRKAAPMTLQLIFLDGEEALKQWGPKDSLYGSRHLAQLMESTPHGLGSTRIQAIELFMLLDLLGAPNPTFYSHFPRTARWFHRLRSIEKRLHRLNLLQSHPWEVMYFQTGEPPGSVEDDHIPFLRRGVPVLHLIATPFPSVWHTSDDSEANLHPPTVHNLSRILAVFLAEYLGL", "length": 289, "header": "tr|A0AAA9S0B5-1|A0AAF6ZAY0_BOVIN Computationally mapped isoform of Glutaminyl-peptide cyclotransferase OS=Bos taurus OX=9913 GN=QPCTL PE=3 SV=1 CANONICAL=A0AAF6ZAY0-1" }, "locus": { "chromosome": "18", "start_pos": 53262378, "end_pos": 53257294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111195.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111195.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075500.1" } ] } }, { "isoform_ac": "A0AAA9S7Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Q3/entry", "sequence": { "sequence": "MKVKSESEVARSCLTFHDPMDCSPPGSPVHGIFQARGQAAMPSGGRGRPRLQVGERSLLERPSPPKRRLIPRAQLLPQLLLALTVASVFYTIWRIWHSQTEELPLGRELRGPLIGSLPEARVRRVVGQLDPHRLWNTFLRPLLVVRTPGSPGNLQVRKFLEATLRTLSAGWHIELDSFTASTPVGPLDFSNVVATLDPGAARHLTLACHYDSKLFPSDSAPFVGATDSAVPCSLLLELAQALDQELGKAKERAAPMTLQLIFLDGEEALKQWGPKDSLYGSRHLAQLMESTPHGLGSTRIQAIELFMLLDLLGAPNPTFYSHFPRTARWFHRLRSIEKRLHRLNLLQSHPWEVMYFQTGEPPGSVEDDHIPFLRRGVPVLHLIATPFPSVWHTSDDSEANLHPPTVHNLSRILAVFLAEYLGL", "length": 423, "header": "tr|A0AAA9S7Q3-1|A0AAF6ZAY0_BOVIN Computationally mapped isoform of Glutaminyl-peptide cyclotransferase OS=Bos taurus OX=9913 GN=QPCTL PE=3 SV=1 CANONICAL=A0AAF6ZAY0-1" }, "locus": { "chromosome": "18", "start_pos": 53262378, "end_pos": 53256660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089040.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089040.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082054.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082054.1" } ] } }, { "isoform_ac": "A0AAA9SIV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV5/entry", "sequence": { "sequence": "MFSGQAAMPSGGRGRPRLQVGERSLLERPSPPKRRLIPRAQLLPQLLLALTVASVFYTIWRIWHSQTEELPLGRELRGPLIGSLPEARVRRVVGQLDPHRLWNTFLRPLLVVRTPGSPGNLQVRKFLEATLRTLSAGWHIELDSFTASTPVGPLDFSNVVATLDPGAARHLTLACHYDSKLFPSDSAPFVGATDSAVPCSLLLELAQALDQELGKAKERAAPMTLQLIFLDGEEALKQWGPKDSLYGSRHLAQLMESTPHGLGSTRIQAIELFMLLDLLGAPNPTFYSHFPRTARWFHRLRSIEKRLHRLNLLQSHPWEVMYFQTGEPPGSVEDDHIPFLRRGVPVLHLIATPFPSVWHTSDDSEANLHPPTVHNLSRILAVFLAEYLGL", "length": 390, "header": "tr|A0AAA9SIV5-1|A0AAF6ZAY0_BOVIN Computationally mapped isoform of Glutaminyl-peptide cyclotransferase OS=Bos taurus OX=9913 GN=QPCTL PE=3 SV=1 CANONICAL=A0AAF6ZAY0-1" }, "locus": { "chromosome": "18", "start_pos": 53262378, "end_pos": 53257000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097290.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097290.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086176.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086176.1" } ] } }, { "isoform_ac": "A0AAF6ZAY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0/entry", "sequence": { "sequence": "MFSVIKRFSLASPPALGRRLLLTLSLWGCATRGNQPPKLPEGKEPSPQAESPIGFTARGRADGAAALVAHWSGLFHGAGLGWALTLSAVSDPFQGQAAMPSGGRGRPRLQVGERSLLERPSPPKRRLIPRAQLLPQLLLALTVASVFYTIWRIWHSQTEELPLGRELRGPLIGSLPEARVRRVVGQLDPHRLWNTFLRPLLVVRTPGSPGNLQVRKFLEATLRTLSAGWHIELDSFTASTPVGPLDFSNVVATLDPGAARHLTLACHYDSKLFPSDSAPFVGATDSAVPCSLLLELAQALDQELGKAKERAAPMTLQLIFLDGEEALKQWGPKDSLYGSRHLAQLMESTPHGLGSTRIQAIELFMLLDLLGAPNPTFYSHFPRTARWFHRLRSIEKRLHRLNLLQSHPWEVMYFQTGEPPGSVEDDHIPFLRRGTCYGNWGTGGPQEFPCSTSSPHPSPLSGTRPMTPRPTCTHPRYTT", "length": 479, "header": "tr|A0AAF6ZAY0-1|A0AAF6ZAY0_BOVIN Isoform 1 of Glutaminyl-peptide cyclotransferase OS=Bos taurus OX=9913 GN=QPCTL PE=3 SV=1 CANONICAL=A0AAF6ZAY0-1" }, "locus": { "chromosome": "18", "start_pos": 53262334, "end_pos": 53257000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032269.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032269.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032205.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032205.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "glutaminyl-peptide cyclotransferase activity", "id": "GO:0016603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016603", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23652", "name": "", "equation": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6R6B5-1", "A0AAF6ZAY0-1", "Q0V8G3-1", "Q28120-1" ], "evidence": [ { "id": "23652", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23652" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZAY0", "gene_name": "QPCTL", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" } ] } ] }, { "uniprot_ac": "F6R6B5", "gene_name": "QPCT", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "F6R6B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6B5" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "F6R6B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6B5" } ] } ] }, { "uniprot_ac": "Q0V8G3", "gene_name": "QPCTL", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "Q0V8G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8G3" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "Q0V8G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8G3" } ] } ] }, { "uniprot_ac": "Q28120", "gene_name": "QPCT", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "Q28120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28120" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "Q28120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28120" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZAY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY0" }, { "id": "PF04389", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04389" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M28", "eco_id": "ECO_0000259", "start_pos": 249, "end_pos": 435, "start_aa": "Asn", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.5", "ec_name": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "2.3.2.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5" }, { "id": "2.3.2.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8G6-1", "uniprot_ac": "A0AAF6Z8G6", "uniprot_id": "A0AAF6Z8G6_BOVIN", "mass": { "chemical_mass": 37559.0, "monoisotopic_mass": 37559.0 }, "refseq": {}, "gene_names": [ { "name": "CTSK", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ] } ], "protein_names": [ { "name": "Cathepsin K", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTSK", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6", "locus": { "chromosome": "3", "start_pos": 19966177, "end_pos": 19953196, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021035", "url": "https://www.ensembl.org/id/ENSBTAG00000021035" } ] } } ], "crossref": [ { "id": "A0AAF6Z8G6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8G6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513038", "url": "https://www.ncbi.nlm.nih.gov/gene/513038", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513038", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513038", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029607", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPINRMWGLTVLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKGDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM", "length": 334, "header": "tr|A0AAF6Z8G6-1|A0AAF6Z8G6_BOVIN Isoform 1 of Cathepsin K OS=Bos taurus OX=9913 GN=CTSK PE=3 SV=1 CANONICAL=A0AAF6Z8G6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS0/entry", "sequence": { "sequence": "MPINRMWGLTVLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKGDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM", "length": 261, "header": "tr|A0AAA9RXS0-1|A0AAF6Z8G6_BOVIN Computationally mapped isoform of Cathepsin K OS=Bos taurus OX=9913 GN=CTSK PE=3 SV=2 CANONICAL=A0AAF6Z8G6-1" }, "locus": { "chromosome": "3", "start_pos": 19965478, "end_pos": 19953312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092792.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092792.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077360.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077360.2" } ] } }, { "isoform_ac": "A0AAA9S3C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C8/entry", "sequence": { "sequence": "MWGLTVLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM", "length": 288, "header": "tr|A0AAA9S3C8-1|A0AAF6Z8G6_BOVIN Computationally mapped isoform of Cathepsin K OS=Bos taurus OX=9913 GN=CTSK PE=3 SV=1 CANONICAL=A0AAF6Z8G6-1" }, "locus": { "chromosome": "3", "start_pos": 19965478, "end_pos": 19955068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102717.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102717.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079607.1" } ] } }, { "isoform_ac": "A0AAF6Z8G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6/entry", "sequence": { "sequence": "MPINRMWGLTVLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKGDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM", "length": 334, "header": "tr|A0AAF6Z8G6-1|A0AAF6Z8G6_BOVIN Isoform 1 of Cathepsin K OS=Bos taurus OX=9913 GN=CTSK PE=3 SV=1 CANONICAL=A0AAF6Z8G6-1" }, "locus": { "chromosome": "3", "start_pos": 19965478, "end_pos": 19953312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028016.8", "url": "https://www.ensembl.org/id/ENSBTAT00000028016.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028016.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028016.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513038", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513038", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "collagen catabolic process", "id": "GO:0030574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030574", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "thyroid hormone generation", "id": "GO:0006590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006590", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "proteoglycan binding", "id": "GO:0043394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043394", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "fibronectin binding", "id": "GO:0001968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8G6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" }, { "id": "SM00848", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cathepsin propeptide inhibitor", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 91, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8G6" }, { "id": "SM00645", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00645" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase C1A papain C-terminal", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 333, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 166, "end_pos": 168 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A0S6-1", "uniprot_ac": "A0AAF7A0S6", "uniprot_id": "A0AAF7A0S6_BOVIN", "mass": { "chemical_mass": 55326.0, "monoisotopic_mass": 55326.0 }, "refseq": {}, "gene_names": [ { "name": "KIAA1191", "type": "recommended", "evidence": [ { "id": "A0AAF7A0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6" } ] } ], "protein_names": [ { "name": "Putative monooxygenase p33MONOX", "type": "recommended", "evidence": [ { "id": "A0AAF7A0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S502#function" }, { "database": "UniProtKB", "id": "ARBA00025240", "url": "https://www.uniprot.org/uniprotkb/ARBA00025240#function" }, { "database": "UniProtKB", "id": "A0AAF6YWD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWD1#function" }, { "database": "UniProtKB", "id": "A0AAF7A0S6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A0S6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA1191", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6", "locus": { "chromosome": "10", "start_pos": 5025729, "end_pos": 5011626, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011608", "url": "https://www.ensembl.org/id/ENSBTAG00000011608" } ] } } ], "crossref": [ { "id": "A0AAF7A0S6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A0S6", "database": "AlphaFoldDB", "categories": [] }, { "id": "508617", "url": "https://www.ncbi.nlm.nih.gov/gene/508617", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28342", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28342", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28342:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28342:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15302", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15302", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S502", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S502-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S502-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A0S6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A0S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLRDRTPPPPPRGGRCCLLPLLVLLTSMNPATNMNPAVPGRGSLLTSGLLSQSAFTSLRTSASLNEKGLRVSLYRAISICPQPVTGPGIECWSRGAFLLGAGGFDTQSPGPKTLSARDDSGSCRIVDYNSQHTPAPPSSCQVSREVTPPRESLSGRLPAAGILFSLPGWRLGPSVSLQAQRRSHHGLDPDCATTFRETWVFGASLVPGRRQLRGGGGRKALEPSGPLGKMSLPIGMYRRAFSYDDALEDPTPMTPPPSDMGSIPWKPVIPERKYQDLAKVEEGEPSVSPPAPAPPPATDSAEKAPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAREERQPASTQSTPSSSPQASPKQKSRGWFTSGSATALPGPSLSTMDSGSGDKDRSSADKWSLFGPRSLQKSESGGFAIQAYKGAQKPSPMEVMRAQATRRAEEPATFKPPKMDIPVMEGTKQLPRAHSLKPRDLNVLTPTGF", "length": 516, "header": "tr|A0AAF7A0S6-1|A0AAF7A0S6_BOVIN Isoform 1 of Putative monooxygenase p33MONOX OS=Bos taurus OX=9913 GN=KIAA1191 PE=3 SV=1 CANONICAL=A0AAF7A0S6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S502-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S502/entry", "sequence": { "sequence": "MQLRDRTPPPPPRGGRCCLLPLLVLLTSMNPATNMNPAVPGRGSLLTSGLLSQSAFTSLRTSASLNEKGLRVSLYRAISICPQPVTGPGIECWSRGAFLLGAGGFDTQSPGPKTLSARDDSGSCRIVDYNSQHTPAPPSSCQVSREVTPPRESLSGRLPAAGILFSLPGWRLGPSVSLQAQRRSHHGLDPDCATTFRETWVFGASLVPGRRQLRGGGGRKEQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAREERQPASTQSTPSSSPQASPKQKSRGWFTSGSATALPGPSLSTMDSGSGDKDRSSADKWSLFGPRSLQKSESGGFAIQAYKGAQKPSPMEVMRAQATRRAEEPATFKPPKMDIPVMEGTKQLPRAHSLKPRDLNVLTPTGF", "length": 414, "header": "tr|A0AAA9S502-1|A0AAF7A0S6_BOVIN Computationally mapped isoform of Putative monooxygenase p33MONOX OS=Bos taurus OX=9913 GN=KIAA1191 PE=3 SV=1 CANONICAL=A0AAF7A0S6-1" }, "locus": { "chromosome": "10", "start_pos": 5024559, "end_pos": 5011811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105022.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105022.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078309.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078309.1" } ] } }, { "isoform_ac": "A0AAF6YWD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWD1/entry", "sequence": { "sequence": "MASRQPEVPALEPSGPLGKMSLPIGMYRRAFSYDDALEDPTPMTPPPSDMGSIPWKPVIPERKYQDLAKQVEEGEPSVSPPAPAPPPATDSAEKAPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAREERQPASTQSTPSSSPQASPKQKSRGWFTSGSATALPGPSLSTMDSGSGDKDRSSADKWSLFGPRSLQKSESGGFAIQAYKGAQKPSPMEVMRAQATRRAEEPATFKPPKMDIPVMEGTKQLPRAHSLKPRDLNVLTPTGF", "length": 306, "header": "tr|A0AAF6YWD1-1|A0AAF7A0S6_BOVIN Computationally mapped isoform of Putative monooxygenase p33MONOX OS=Bos taurus OX=9913 GN=KIAA1191 PE=3 SV=1 CANONICAL=A0AAF7A0S6-1" }, "locus": { "chromosome": "10", "start_pos": 5024559, "end_pos": 5013953, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015420.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015420.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015420.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015420.4" } ] } }, { "isoform_ac": "A0AAF7A0S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6/entry", "sequence": { "sequence": "MQLRDRTPPPPPRGGRCCLLPLLVLLTSMNPATNMNPAVPGRGSLLTSGLLSQSAFTSLRTSASLNEKGLRVSLYRAISICPQPVTGPGIECWSRGAFLLGAGGFDTQSPGPKTLSARDDSGSCRIVDYNSQHTPAPPSSCQVSREVTPPRESLSGRLPAAGILFSLPGWRLGPSVSLQAQRRSHHGLDPDCATTFRETWVFGASLVPGRRQLRGGGGRKALEPSGPLGKMSLPIGMYRRAFSYDDALEDPTPMTPPPSDMGSIPWKPVIPERKYQDLAKVEEGEPSVSPPAPAPPPATDSAEKAPVVKAKATHVIMSSLITKQTQESIQRFEQQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGETAREERQPASTQSTPSSSPQASPKQKSRGWFTSGSATALPGPSLSTMDSGSGDKDRSSADKWSLFGPRSLQKSESGGFAIQAYKGAQKPSPMEVMRAQATRRAEEPATFKPPKMDIPVMEGTKQLPRAHSLKPRDLNVLTPTGF", "length": 516, "header": "tr|A0AAF7A0S6-1|A0AAF7A0S6_BOVIN Isoform 1 of Putative monooxygenase p33MONOX OS=Bos taurus OX=9913 GN=KIAA1191 PE=3 SV=1 CANONICAL=A0AAF7A0S6-1" }, "locus": { "chromosome": "10", "start_pos": 5024559, "end_pos": 5011811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083010.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083010.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060668.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060668.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 255, "start_aa": "Thr", "end_pos": 255, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr255", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 386, "start_aa": "Thr", "end_pos": 386, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr386", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A0S6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A0S6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0S6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 255, 386 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0E4-1", "uniprot_ac": "A0AAF6Z0E4", "uniprot_id": "A0AAF6Z0E4_BOVIN", "mass": { "chemical_mass": 92682.0, "monoisotopic_mass": 92682.0 }, "refseq": { "ac": "XP_005214665", "name": "DNA helicase MCM8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214665" }, "gene_names": [ { "name": "MCM8", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "name": "MCM8", "type": "synonym", "evidence": [ { "id": "XP_005214665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214665" } ] } ], "protein_names": [ { "name": "DNA helicase MCM8", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4/entry#names_and_taxonomy" } ] }, { "name": "5.6.2.4", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4/entry#names_and_taxonomy" } ] }, { "name": "DNA 3'-5' helicase MCM8", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4/entry#names_and_taxonomy" } ] }, { "name": "DNA helicase MCM8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214665" } ] }, { "name": "Minichromosome maintenance 8", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4", "locus": { "chromosome": "13", "start_pos": 48166976, "end_pos": 48120744, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014623", "url": "https://www.ensembl.org/id/ENSBTAG00000014623" } ] } } ], "crossref": [ { "id": "A0AAF6Z0E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17759", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17759", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22247", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22247", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507507", "url": "https://www.ncbi.nlm.nih.gov/gene/507507", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11630:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11630:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26065", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26065", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214665", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214665", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S6V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGKYRGRGFGQGRFQSWKSGRGGRGFSGKWREREHRPDLNKATGKHPEQTPQSLLLQSTLDHFIPYKGWKLYFSEVYSDSIPFIEKIEAFESFFTERIELYDKDEIERKGSILVDFKELINDDEIIKLIPNIANELRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDGKYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAEEGSRNKNDKCMFLLYIEANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM", "length": 832, "header": "tr|A0AAF6Z0E4-1|A0AAF6Z0E4_BOVIN Isoform 1 of DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE=3 SV=1 CANONICAL=A0AAF6Z0E4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6V5/entry", "sequence": { "sequence": "MNGKYRGRGFGQGRFQSWKSGRGGRGFSGKWREREHRPDLNKATGKHPEQTPQSLLLQSTLDHFIPYKGWKLYFSEVYSDSIPFIEKIEAFESFFTERIELYDKDEIERKGSILVDFKELINDDEIIKLIPNIANELRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDGKYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAEEGSRNKNDKCMFLLYIEANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHEAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM", "length": 785, "header": "tr|A0AAA9S6V5-1|A0AAF6Z0E4_BOVIN Computationally mapped isoform of DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE=3 SV=1 CANONICAL=A0AAF6Z0E4-1" }, "locus": { "chromosome": "13", "start_pos": 48166660, "end_pos": 48123958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119412.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119412.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079023.1" } ] } }, { "isoform_ac": "A0AAA9SJ42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ42/entry", "sequence": { "sequence": "MNGKYRGRGFGQGRFQSWKSGRGGRGFSGKWREREHRPDLNKATGKHPEQTPQSLLLQSTLDHFIPYKGWKLYFSEVYSDSIPFIEKIEAFESFFTERIELYDKVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDGKYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAEEGSRNKNDKCMFLLYIEANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM", "length": 782, "header": "tr|A0AAA9SJ42-1|A0AAF6Z0E4_BOVIN Computationally mapped isoform of DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE=3 SV=1 CANONICAL=A0AAF6Z0E4-1" }, "locus": { "chromosome": "13", "start_pos": 48166660, "end_pos": 48123958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120320.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120320.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083824.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083824.1" } ] } }, { "isoform_ac": "A0AAA9TRA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA5/entry", "sequence": { "sequence": "MNGKYRGRGFGQGRFQSWKSGRGGRGFSGKWREREHRPDLNKATGKHPVYSDSIPFIEKIEAFESFFTERIELYDKDEIERKGSILVDFKELINDDEIIKLIPNIANELRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDGKYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAEEGSRNKNDKCMFLLYIEANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM", "length": 804, "header": "tr|A0AAA9TRA5-1|A0AAF6Z0E4_BOVIN Computationally mapped isoform of DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE=3 SV=1 CANONICAL=A0AAF6Z0E4-1" }, "locus": { "chromosome": "13", "start_pos": 48166660, "end_pos": 48123958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114682.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114682.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101133.1" } ] } }, { "isoform_ac": "A0AAF6Z0E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4/entry", "sequence": { "sequence": "MNGKYRGRGFGQGRFQSWKSGRGGRGFSGKWREREHRPDLNKATGKHPEQTPQSLLLQSTLDHFIPYKGWKLYFSEVYSDSIPFIEKIEAFESFFTERIELYDKDEIERKGSILVDFKELINDDEIIKLIPNIANELRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDGKYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAEEGSRNKNDKCMFLLYIEANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM", "length": 832, "header": "tr|A0AAF6Z0E4-1|A0AAF6Z0E4_BOVIN Isoform 1 of DNA helicase MCM8 OS=Bos taurus OX=9913 GN=MCM8 PE=3 SV=1 CANONICAL=A0AAF6Z0E4-1" }, "locus": { "chromosome": "13", "start_pos": 48166660, "end_pos": 48123958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019471.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019471.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019471.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019471.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "3'-5' DNA helicase activity", "id": "GO:0043138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043138", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "MutSalpha complex binding", "id": "GO:0032407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032407", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "MutLbeta complex binding", "id": "GO:0032406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032406", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "MutSbeta complex binding", "id": "GO:0032408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032408", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "MCM8-MCM9 complex", "id": "GO:0097362", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097362", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "female gamete generation", "id": "GO:0007292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007292", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "male gamete generation", "id": "GO:0048232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048232", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" }, { "name": "recombinational interstrand cross-link repair", "id": "GO:0036298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036298", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" }, { "id": "PS50051", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50051" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MCM C-terminal AAA(+) ATPase", "eco_id": "ECO_0000259", "start_pos": 394, "end_pos": 601, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" }, { "id": "PRU01410", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01410" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Walker A", "eco_id": "ECO_0000256", "start_pos": 463, "end_pos": 470, "start_aa": "Ala", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" }, { "id": "PRU01410", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01410" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Walker B", "eco_id": "ECO_0000256", "start_pos": 526, "end_pos": 529, "start_aa": "Met", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.6.2.4", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "5.6.2.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4" }, { "id": "5.6.2.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.6.2.4" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 472, "end_pos": 474 }, { "start_pos": 626, "end_pos": 628 }, { "start_pos": 764, "end_pos": 766 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCF0-1", "uniprot_ac": "A0AAF6ZCF0", "uniprot_id": "A0AAF6ZCF0_BOVIN", "mass": { "chemical_mass": 36687.0, "monoisotopic_mass": 36687.0 }, "refseq": {}, "gene_names": [ { "name": "PGAP3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0" } ] } ], "protein_names": [ { "name": "Post-GPI attachment to proteins factor 3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H3#function" }, { "database": "UniProtKB", "id": "ARBA00093305", "url": "https://www.uniprot.org/uniprotkb/ARBA00093305#function" }, { "database": "UniProtKB", "id": "A0AAA9SY95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY95#function" }, { "database": "UniProtKB", "id": "A0AAA9SD76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD76#function" }, { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0#function" } ] }, { "annotation": "Involved in the lipid remodeling steps of GPI-anchor maturation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H3#function" }, { "database": "UniProtKB", "id": "RU365066", "url": "https://www.uniprot.org/uniprotkb/RU365066#function" }, { "database": "UniProtKB", "id": "A0AAA9SY95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY95#function" }, { "database": "UniProtKB", "id": "A0AAA9SD76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD76#function" }, { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0", "locus": { "chromosome": "19", "start_pos": 40047114, "end_pos": 40061042, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011732", "url": "https://www.ensembl.org/id/ENSBTAG00000011732" } ] } } ], "crossref": [ { "id": "A0AAF6ZCF0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "513258", "url": "https://www.ncbi.nlm.nih.gov/gene/513258", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13148", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13148", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13148:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13148:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04080", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04080", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "83847", "url": "https://www.rhea-db.org/rhea/83847", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRTARLVLLAGAAALASGSQGDREPVYRDCVLRCEERNCSGGALKHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGQKVPQFHGKWPFSRFLCFQEPASAVASFLNGLASLVMLCRYRTSVPASSPMYPTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVSSGWRGRTVGLQHPAMASAFRALLLLLLTAHVSYLSLIHFDYGYNMAANVAIGLLNAAWWLAWCLWNQRLPHVHKCVAVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEAKVKLD", "length": 325, "header": "tr|A0AAF6ZCF0-1|A0AAF6ZCF0_BOVIN Isoform 1 of Post-GPI attachment to proteins factor 3 OS=Bos taurus OX=9913 GN=PGAP3 PE=3 SV=1 CANONICAL=A0AAF6ZCF0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H3/entry", "sequence": { "sequence": "MAGRTARLVLLAGAAALASGSQGDREPVYRDCVLRCEERNCSGGALKHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGQKVPQFHGKWPFSRFLCFQEPASAVASFLNGLASLVMLCRYRTSVPASSPMYPTCVAFAWKMDYFCASTVILHSIYLCCVRTVGLQHPAMASAFRALLLLLLTAHVSYLSLIHFDYGYNMAANVAIGLLNAAWWLAWCLWNQRLPHVHKCVAVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEAKVKLD", "length": 298, "header": "tr|A0AAA9S9H3-1|A0AAF6ZCF0_BOVIN Computationally mapped isoform of Post-GPI attachment to proteins factor 3 OS=Bos taurus OX=9913 GN=PGAP3 PE=3 SV=1 CANONICAL=A0AAF6ZCF0-1" }, "locus": { "chromosome": "19", "start_pos": 40061028, "end_pos": 40048711, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078787.1" } ] } }, { "isoform_ac": "A0AAA9SD76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD76/entry", "sequence": { "sequence": "MAGRTARLVLLAGAAALASGSQGDREPVYRDCVLRCEERNCSGGALKHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGQKVPQFHGKWPFSRFLCFQEPASAVASFLNGLASLVMLCRYRTSVPASSPMYPTCVAFAWLSGR", "length": 148, "header": "tr|A0AAA9SD76-1|A0AAF6ZCF0_BOVIN Computationally mapped isoform of Post-GPI attachment to proteins factor 3 OS=Bos taurus OX=9913 GN=PGAP3 PE=3 SV=1 CANONICAL=A0AAF6ZCF0-1" }, "locus": { "chromosome": "19", "start_pos": 40061028, "end_pos": 40048760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117585.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117585.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083360.1" } ] } }, { "isoform_ac": "A0AAA9SY95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY95/entry", "sequence": { "sequence": "MAGRTARLVLLAGAAALASGSQGDREPVYRDCVLRCEERNCSGGALKHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGQKVPQFHGKVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAMASAFRALLLLLLTAHVSYLSLIHFDYGYNMAANVAIGLLNAAWWLAWCLWNQRLPHVHKCVAVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEAKVKLD", "length": 268, "header": "tr|A0AAA9SY95-1|A0AAF6ZCF0_BOVIN Computationally mapped isoform of Post-GPI attachment to proteins factor 3 OS=Bos taurus OX=9913 GN=PGAP3 PE=3 SV=1 CANONICAL=A0AAF6ZCF0-1" }, "locus": { "chromosome": "19", "start_pos": 40061028, "end_pos": 40048711, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102995.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102995.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089226.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089226.1" } ] } }, { "isoform_ac": "A0AAF6ZCF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0/entry", "sequence": { "sequence": "MAGRTARLVLLAGAAALASGSQGDREPVYRDCVLRCEERNCSGGALKHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGQKVPQFHGKWPFSRFLCFQEPASAVASFLNGLASLVMLCRYRTSVPASSPMYPTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVSSGWRGRTVGLQHPAMASAFRALLLLLLTAHVSYLSLIHFDYGYNMAANVAIGLLNAAWWLAWCLWNQRLPHVHKCVAVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEAKVKLD", "length": 325, "header": "tr|A0AAF6ZCF0-1|A0AAF6ZCF0_BOVIN Isoform 1 of Post-GPI attachment to proteins factor 3 OS=Bos taurus OX=9913 GN=PGAP3 PE=3 SV=1 CANONICAL=A0AAF6ZCF0-1" }, "locus": { "chromosome": "19", "start_pos": 40061028, "end_pos": 40048711, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034874.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034874.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034758.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034758.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydrolase activity, acting on ester bonds", "id": "GO:0016788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016788", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "83847", "name": "", "equation": "[protein]-C-terminal carboxyl phosphoethanolamide-GPI(deacylinositol-H7) + H2O = [protein]-C-terminal carboxyl phosphoethanolamide-lysoGPI(deacylinositol-H7) + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7YWP2-1" ], "evidence": [ { "id": "83847", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83847" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A7YWP2", "gene_name": "PGAP3", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "A7YWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWP2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 40, "end_pos": 42 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A9V6-1", "uniprot_ac": "A0AAF7A9V6", "uniprot_id": "A0AAF7A9V6_BOVIN", "mass": { "chemical_mass": 14924.0, "monoisotopic_mass": 14924.0 }, "refseq": {}, "gene_names": [ { "name": "SPX", "type": "recommended", "evidence": [ { "id": "A0AAF7A9V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ] } ], "protein_names": [ { "name": "Spexin hormone", "type": "synonym", "evidence": [ { "id": "A0AAF7A9V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPX", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6", "locus": { "chromosome": "5", "start_pos": 88663823, "end_pos": 88673433, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053951", "url": "https://www.ensembl.org/id/ENSBTAG00000053951" } ] } } ], "crossref": [ { "id": "A0AAF7A9V6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A9V6", "database": "AlphaFoldDB", "categories": [] }, { "id": "509493", "url": "https://www.ncbi.nlm.nih.gov/gene/509493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28590", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28590", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28590:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28590:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGFKSLVVMTLTLFLVFSFMGNCNSAPQVITSKNWGSSMRWRLFERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLSDRPPLERRSPNSQQLTLPEAAAVLLAFLQKPQEAGDENLDQTRFLEDSLLNW", "length": 129, "header": "tr|A0AAF7A9V6-1|A0AAF7A9V6_BOVIN Isoform 1 of Spexin hormone OS=Bos taurus OX=9913 GN=SPX PE=3 SV=1 CANONICAL=A0AAF7A9V6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD5/entry", "sequence": { "sequence": "MQGFKSLVVMTLTLFLVFSFMGNCNSAPQRLFERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLSDRPPLERRSPNSQQLTLPEAAAVLLAFLQKPQEAGDENLDQTRFLEDSLLNW", "length": 116, "header": "tr|A0AAA9SDD5-1|A0AAF7A9V6_BOVIN Computationally mapped isoform of Spexin hormone OS=Bos taurus OX=9913 GN=SPX PE=3 SV=1 CANONICAL=A0AAF7A9V6-1" }, "locus": { "chromosome": "5", "start_pos": 88672966, "end_pos": 88664907, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124270.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124270.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080336.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080336.1" } ] } }, { "isoform_ac": "A0AAF7A9V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6/entry", "sequence": { "sequence": "MKGFKSLVVMTLTLFLVFSFMGNCNSAPQVITSKNWGSSMRWRLFERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLSDRPPLERRSPNSQQLTLPEAAAVLLAFLQKPQEAGDENLDQTRFLEDSLLNW", "length": 129, "header": "tr|A0AAF7A9V6-1|A0AAF7A9V6_BOVIN Isoform 1 of Spexin hormone OS=Bos taurus OX=9913 GN=SPX PE=3 SV=1 CANONICAL=A0AAF7A9V6-1" }, "locus": { "chromosome": "5", "start_pos": 88673364, "end_pos": 88664907, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070012.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070012.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065237.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065237.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ], "pmid": "" }, { "name": "dense core granule", "id": "GO:0031045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "neuropeptide hormone activity", "id": "GO:0005184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005184", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of gastro-intestinal system smooth muscle contraction", "id": "GO:1904306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904306", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9V6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9V6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZWM0-1", "uniprot_ac": "A0AAF6ZWM0", "uniprot_id": "A0AAF6ZWM0_BOVIN", "mass": { "chemical_mass": 103889.0, "monoisotopic_mass": 103889.0 }, "refseq": {}, "gene_names": [ { "name": "AASS", "type": "recommended", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ] } ], "protein_names": [ { "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0/entry#names_and_taxonomy" } ] }, { "name": "1.5.1.8", "type": "synonym", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0/entry#names_and_taxonomy" } ] }, { "name": "1.5.1.9", "type": "synonym", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0/entry#names_and_taxonomy" } ] }, { "name": "LKR/SDH", "type": "synonym", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Bifunctional enzyme that catalyzes the first two steps in lysine degradation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YXC0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXC0#function" }, { "database": "UniProtKB", "id": "ARBA00055923", "url": "https://www.uniprot.org/uniprotkb/ARBA00055923#function" }, { "database": "UniProtKB", "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0#function" }, { "database": "UniProtKB", "id": "A0AAA9SN35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN35#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AASS", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0", "locus": { "chromosome": "4", "start_pos": 86516905, "end_pos": 86594686, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012128", "url": "https://www.ensembl.org/id/ENSBTAG00000012128" } ] } } ], "crossref": [ { "id": "A0AAF6ZWM0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZWM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12189", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12189", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007698", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11133", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11133", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11133:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11133:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19373", "url": "https://www.rhea-db.org/rhea/19373", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24520", "url": "https://www.rhea-db.org/rhea/24520", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SN35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXC0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YXC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZWM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPWLLLEEICFPGFKMLRVSRTKLGRLSPSLSRGLHHKAVMALRREDVNAWERRAPLAPRHVKGITNLGYKVLIQPSNRRAIHDKEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFMHIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPCEYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTKKKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKLSSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGELGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMNIMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTLLRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLKEAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFSKEIYGPILERIKAEGIMYTTQSTIKL", "length": 941, "header": "tr|A0AAF6ZWM0-1|A0AAF6ZWM0_BOVIN Isoform 1 of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Bos taurus OX=9913 GN=AASS PE=3 SV=1 CANONICAL=A0AAF6ZWM0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN35/entry", "sequence": { "sequence": "MKVKSESEVAQSCPTPSDPMDCSLPGSSAHGIFQEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFMHIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPCEYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTKKKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKLSSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGELGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMNIMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTLLRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLKEAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFSKEIYGPILERIKAEGIMYTTQSTIKL", "length": 890, "header": "tr|A0AAA9SN35-1|A0AAF6ZWM0_BOVIN Computationally mapped isoform of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Bos taurus OX=9913 GN=AASS PE=3 SV=1 CANONICAL=A0AAF6ZWM0-1" }, "locus": { "chromosome": "4", "start_pos": 86584694, "end_pos": 86517278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108951.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108951.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084223.1" } ] } }, { "isoform_ac": "A0AAF6YXC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXC0/entry", "sequence": { "sequence": "MSPGFKMLRVSRTKLGRLSPSLSRGLHHKAVMALRREDVNAWERRAPLAPRHVKGITNLGYKVLIQPSNRRAIHDKEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFMHIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPCEYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTKKKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKLSSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGELGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMNIMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTLLRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLKEAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFSKEIYGPILERIKAEGIMYTTQSTIKL", "length": 932, "header": "tr|A0AAF6YXC0-1|A0AAF6ZWM0_BOVIN Computationally mapped isoform of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Bos taurus OX=9913 GN=AASS PE=3 SV=1 CANONICAL=A0AAF6ZWM0-1" }, "locus": { "chromosome": "4", "start_pos": 86588722, "end_pos": 86517278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016090.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016090.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016090.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016090.7" } ] } }, { "isoform_ac": "A0AAF6ZWM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0/entry", "sequence": { "sequence": "MPWLLLEEICFPGFKMLRVSRTKLGRLSPSLSRGLHHKAVMALRREDVNAWERRAPLAPRHVKGITNLGYKVLIQPSNRRAIHDKEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFMHIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPCEYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTKKKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKLSSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGELGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMNIMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTLLRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLKEAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFSKEIYGPILERIKAEGIMYTTQSTIKL", "length": 941, "header": "tr|A0AAF6ZWM0-1|A0AAF6ZWM0_BOVIN Isoform 1 of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Bos taurus OX=9913 GN=AASS PE=3 SV=1 CANONICAL=A0AAF6ZWM0-1" }, "locus": { "chromosome": "4", "start_pos": 86593758, "end_pos": 86517278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080443.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080443.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058471.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058471.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 595, "start_aa": "Thr", "end_pos": 595, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr595", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lysine catabolic process", "id": "GO:0006554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006554", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "id": "GO:0047130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047130", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ], "pmid": "" }, { "name": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "id": "GO:0047131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047131", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 868, "end_pos": 870, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19373", "name": "", "equation": "L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A8E657-1", "A0AAF6ZWM0-1" ], "evidence": [ { "id": "19373", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19373" } ] }, { "id": "24520", "name": "", "equation": "L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A8E657-1", "A0AAF6ZWM0-1" ], "evidence": [ { "id": "24520", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24520" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZWM0", "gene_name": "AASS", "activity": [ { "ec_number": "1.5.1.8", "activity": "L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+).", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ] }, { "ec_number": "1.5.1.9", "activity": "L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+).", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ] }, { "ec_number": "1.5.1.8", "activity": "", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ] }, { "ec_number": "1.5.1.9", "activity": "", "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" } ] } ] }, { "uniprot_ac": "A8E657", "gene_name": "AASS", "activity": [ { "ec_number": "1.5.1.8", "activity": "L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+).", "evidence": [ { "id": "A8E657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E657" } ] }, { "ec_number": "1.5.1.9", "activity": "L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+).", "evidence": [ { "id": "A8E657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E657" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" }, { "id": "SM01003", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 172, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWM0" }, { "id": "SM01002", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 414, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.5.1.8", "ec_name": "L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+).", "evidence": [ { "id": "1.5.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.8" }, { "id": "1.5.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.8" } ] }, { "ec_number": "1.5.1.9", "ec_name": "L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+).", "evidence": [ { "id": "1.5.1.9", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.9" }, { "id": "1.5.1.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.9" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 595 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 241, "end_pos": 243 }, { "start_pos": 454, "end_pos": 456 }, { "start_pos": 868, "end_pos": 870 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z3H7-1", "uniprot_ac": "A0AAF6Z3H7", "uniprot_id": "A0AAF6Z3H7_BOVIN", "mass": { "chemical_mass": 43061.0, "monoisotopic_mass": 43061.0 }, "refseq": {}, "gene_names": [ { "name": "CTSS", "type": "recommended", "evidence": [ { "id": "A0AAF6Z3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ] } ], "protein_names": [ { "name": "Cathepsin S", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTSS", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7", "locus": { "chromosome": "3", "start_pos": 20004455, "end_pos": 19981414, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017135", "url": "https://www.ensembl.org/id/ENSBTAG00000017135" } ] } } ], "crossref": [ { "id": "A0AAF6Z3H7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z3H7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3H7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVHFLIVDASCDKFQFLFKVTLAESHFENFGESPPSAFLVWEDLLVLSRIMNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYYDPSCTQNVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNSGNHCGIANYPSYPEI", "length": 382, "header": "tr|A0AAF6Z3H7-1|A0AAF6Z3H7_BOVIN Isoform 1 of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X9/entry", "sequence": { "sequence": "MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYYDPSCTQNVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNSGNHCGIANYPSYPEI", "length": 240, "header": "tr|A0AAA9S5X9-1|A0AAF6Z3H7_BOVIN Computationally mapped isoform of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 20003829, "end_pos": 19982535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104032.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104032.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080625.1" } ] } }, { "isoform_ac": "A0AAA9SNA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA8/entry", "sequence": { "sequence": "MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMLGPALW", "length": 215, "header": "tr|A0AAA9SNA8-1|A0AAF6Z3H7_BOVIN Computationally mapped isoform of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 20003750, "end_pos": 19982535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122794.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122794.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085451.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085451.1" } ] } }, { "isoform_ac": "A0AAA9SPN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPN6/entry", "sequence": { "sequence": "MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYYDPSCTQNVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNSGNHCGIANYPSYPEI", "length": 255, "header": "tr|A0AAA9SPN6-1|A0AAF6Z3H7_BOVIN Computationally mapped isoform of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 20003829, "end_pos": 19982535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107245.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107245.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085897.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085897.1" } ] } }, { "isoform_ac": "A0AAA9T0P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P6/entry", "sequence": { "sequence": "MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYYDPSCTQNVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNSGNHCGIANYPSYPEI", "length": 281, "header": "tr|A0AAA9T0P6-1|A0AAF6Z3H7_BOVIN Computationally mapped isoform of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 20003829, "end_pos": 19982535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089951.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089951.1" } ] } }, { "isoform_ac": "A0AAA9TQ91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ91/entry", "sequence": { "sequence": "MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMVCLKLTFCTAPYKEG", "length": 224, "header": "tr|A0AAA9TQ91-1|A0AAF6Z3H7_BOVIN Computationally mapped isoform of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 19988879, "end_pos": 19982535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097359.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097359.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100536.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100536.1" } ] } }, { "isoform_ac": "A0AAA9TUL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL9/entry", "sequence": { "sequence": "MNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTAGACTLVTKDIYGWQEIVEITVGLLIILLTQKSRGLLCFITIQEKR", "length": 310, "header": "tr|A0AAA9TUL9-1|A0AAF6Z3H7_BOVIN Computationally mapped isoform of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 20003869, "end_pos": 19982535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125539.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125539.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100269.1" } ] } }, { "isoform_ac": "A0AAF6Z3H7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7/entry", "sequence": { "sequence": "MKVHFLIVDASCDKFQFLFKVTLAESHFENFGESPPSAFLVWEDLLVLSRIMNWLVWALLLCSSAMAHVHRDPTLDHHWDLWKKTYGKQYKEKNEEVARRLIWEKNLKTVTLHNLEHSMGMHSYELGMNHLGDMTSEEVISLMSSLRVPSQWPRNVTYKSDPNQKLPDSMDWREKGCVTEVKYQGACGSCWAFSAVGALEAQVKLKTGKLVSLSAQNLVDCSTAKYGNKGCNGGFMTEAFQYIIDNNGIDSEASYPYKAMDGKCQYDVKNRAATCSRYIELPFGSEEALKEAVANKGPVSVGIDASHSSFFLYKTGVYYDPSCTQNVNHGVLVVGYGNLDGKDYWLVKNSWGLHFGDQGYIRMARNSGNHCGIANYPSYPEI", "length": 382, "header": "tr|A0AAF6Z3H7-1|A0AAF6Z3H7_BOVIN Isoform 1 of Cathepsin S OS=Bos taurus OX=9913 GN=CTSS PE=3 SV=1 CANONICAL=A0AAF6Z3H7-1" }, "locus": { "chromosome": "3", "start_pos": 20003829, "end_pos": 19981445, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022774.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022774.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022774.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022774.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "antigen processing and presentation of exogenous peptide antigen via MHC class II", "id": "GO:0019886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "collagen catabolic process", "id": "GO:0030574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030574", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "response to acidic pH", "id": "GO:0010447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010447", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "cellular response to thyroid hormone stimulus", "id": "GO:0097067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097067", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "basement membrane disassembly", "id": "GO:0034769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034769", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "regulation of antigen processing and presentation", "id": "GO:0002577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002577", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "laminin binding", "id": "GO:0043236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043236", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "proteoglycan binding", "id": "GO:0043394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043394", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "fibronectin binding", "id": "GO:0001968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3H7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" }, { "id": "SM00848", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cathepsin propeptide inhibitor", "eco_id": "ECO_0000259", "start_pos": 79, "end_pos": 139, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3H7" }, { "id": "SM00645", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00645" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase C1A papain C-terminal", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 381, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A5X7-1", "uniprot_ac": "A0AAF7A5X7", "uniprot_id": "A0AAF7A5X7_BOVIN", "mass": { "chemical_mass": 41861.0, "monoisotopic_mass": 41861.0 }, "refseq": {}, "gene_names": [ { "name": "FAIM2", "type": "recommended", "evidence": [ { "id": "A0AAF7A5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ] } ], "protein_names": [ { "name": "Protein lifeguard 2", "type": "recommended", "evidence": [ { "id": "A0AAF7A5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7/entry#names_and_taxonomy" } ] }, { "name": "Fas apoptotic inhibitory molecule 2", "type": "synonym", "evidence": [ { "id": "A0AAF7A5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAIM2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7", "locus": { "chromosome": "5", "start_pos": 30015450, "end_pos": 29956286, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017504", "url": "https://www.ensembl.org/id/ENSBTAG00000017504" } ] } } ], "crossref": [ { "id": "A0AAF7A5X7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A5X7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10428", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10428", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23291:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23291:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQGKLSVANKAPGTEGQQQANGEKKETPAVPSAPPSYEEATSGEGLKAGAFPPAPSAVPLHPSWAYVDPNSSSSYESGFPTGDHEFFTTFSWDDQKVRRVFIRKVYTILLIQLLVTLGVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLSITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAVLGAGVFTLTLFHSEFGDSFASLVSMSLRDPVREPSLFGSPPSATTAALIPHLMPHLNPGVQMNSSEGRRREGGLTSNCSFRRKVRSCPAPAPHLSLTSSDTNPQKPTPCSNQALQTNTLTRRR", "length": 382, "header": "tr|A0AAF7A5X7-1|A0AAF7A5X7_BOVIN Isoform 1 of Protein lifeguard 2 OS=Bos taurus OX=9913 GN=FAIM2 PE=3 SV=1 CANONICAL=A0AAF7A5X7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY7/entry", "sequence": { "sequence": "TSETLSVANKAPGTEGQQQANGEKKETPAVPSAPPSYEEATSGEGLKAGAFPPAPSAVPLHPSWAYVDPNSSSSYESGFPTGDHEFFTTFSWDDQKVRRVFIRKVYTILLIQLLVTLGVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLSITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGSRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE", "length": 315, "header": "tr|A0AAA9SNY7-1|A0AAF7A5X7_BOVIN Computationally mapped isoform of Protein lifeguard 2 OS=Bos taurus OX=9913 GN=FAIM2 PE=3 SV=1 CANONICAL=A0AAF7A5X7-1" }, "locus": { "chromosome": "5", "start_pos": 30015339, "end_pos": 29956599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110784.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110784.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085665.1" } ] } }, { "isoform_ac": "A0AAF7A5X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7/entry", "sequence": { "sequence": "MTQGKLSVANKAPGTEGQQQANGEKKETPAVPSAPPSYEEATSGEGLKAGAFPPAPSAVPLHPSWAYVDPNSSSSYESGFPTGDHEFFTTFSWDDQKVRRVFIRKVYTILLIQLLVTLGVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLSITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAVLGAGVFTLTLFHSEFGDSFASLVSMSLRDPVREPSLFGSPPSATTAALIPHLMPHLNPGVQMNSSEGRRREGGLTSNCSFRRKVRSCPAPAPHLSLTSSDTNPQKPTPCSNQALQTNTLTRRR", "length": 382, "header": "tr|A0AAF7A5X7-1|A0AAF7A5X7_BOVIN Isoform 1 of Protein lifeguard 2 OS=Bos taurus OX=9913 GN=FAIM2 PE=3 SV=1 CANONICAL=A0AAF7A5X7-1" }, "locus": { "chromosome": "5", "start_pos": 30009335, "end_pos": 29984435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068256.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068256.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063728.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063728.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" }, { "name": "cerebellar granular layer development", "id": "GO:0021681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021681", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" }, { "name": "regulation of neuron apoptotic process", "id": "GO:0043523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043523", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" }, { "name": "cerebellar Purkinje cell differentiation", "id": "GO:0021702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021702", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5X7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z2G3-1", "uniprot_ac": "A0AAF6Z2G3", "uniprot_id": "A0AAF6Z2G3_BOVIN", "mass": { "chemical_mass": 111820.0, "monoisotopic_mass": 111820.0 }, "refseq": {}, "gene_names": [ { "name": "GAA", "type": "recommended", "evidence": [ { "id": "A0AAF6Z2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ] } ], "protein_names": [ { "name": "Lysosomal alpha-glucosidase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.20", "type": "synonym", "evidence": [ { "id": "A0AAF6Z2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3/entry#names_and_taxonomy" } ] }, { "name": "Acid maltase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3#function" }, { "database": "UniProtKB", "id": "ARBA00045686", "url": "https://www.uniprot.org/uniprotkb/ARBA00045686#function" }, { "database": "UniProtKB", "id": "A0AAA9SPK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAA", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3", "locus": { "chromosome": "19", "start_pos": 52482934, "end_pos": 52499380, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016021", "url": "https://www.ensembl.org/id/ENSBTAG00000016021" } ] } } ], "crossref": [ { "id": "A0AAF6Z2G3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z2G3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00111", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00111", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06602", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06602", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14752", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14752", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762:SF92", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762:SF92", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00088", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00088", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13802", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13802", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21365", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21365", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METGKGWGAALTVPLATSSTSEVWVGRAKTFHSEFPKFLNNHHHRCVWQSQVELVHCVIHCPPMMRWPPCSRPLLGVCTLLSLALLGHILLHDLEVVPRELRGFSQDEIHQACQPGASSPECRGSPRAAPTQCDLPPNSRFDCAPDKGITPQQCEARGCCYMPAEWPPDAQMGQPWCFFPPSYPSYRLENLTTTETGYTATLTRAVPTFFPKDIMTLRLDMLMETESRLHFTIKDPANRRYEVPLETPRVYSQAPFTLYSVEFSEEPFGVVVRRKLDGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLAEHLGSLMLSTNWTKITLWNRDIAPEPNVNLYGSHPFYLVLEDGGLAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSTSAITRQVVENMTRAYFPLDVQWNDLDYMDARRDFTFNKDHFGDFPAMVQELHQGGRRYIMIVDPAISSSGPAGTYRPYDEGLRRGVFITNETGQPLIGQVWPGLTAFPDFTNPETLDWWQDMVTEFHAQVPFDGMWIDMNEPSNFVRGSVDGCPDNSLENPPYLPGVVGGTLRAATICASSHQFLSTHYDLHNLYGLTEALASHRALVKARGMRPFVISRSTFAGHGRYSGHWTGDVWSNWEQLSYSVPEILLFNLLGVPLVGADICGFLGNTSEELCVRWTQLGAFYPFMRNHNALNSQPQEPYRFSETAQQAMRKAFTLRYVLLPYLYTLFHRAHVRGETVARPLFLEFPEDPSTWTVDRQLLWGEALLITPVLEAEKVEVTGYFPQGTWYDLQTVPMEAFGSLPPPAPLTSVIHSKGQWVTLSAPLDTINVHLRAGHIIPMQGPALTTTESRKQHMALAVALTASGEAQGELFWDDGESLGVLDGGDYTQLIFLAKNNTFVNKLVHVSSEGASLQLRNVTVLGVATAPQQVLCNSVPVSNFTFSPDTETLAIPVSLTMGEQFVISWS", "length": 1000, "header": "tr|A0AAF6Z2G3-1|A0AAF6Z2G3_BOVIN Isoform 1 of Lysosomal alpha-glucosidase OS=Bos taurus OX=9913 GN=GAA PE=3 SV=1 CANONICAL=A0AAF6Z2G3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK2/entry", "sequence": { "sequence": "MMRWPPCSRPLLGVCTLLSLALLGHILLHDLEVVPRELRGFSQDEIHQACQPGASSPECRGSPRAAPTQCDLPPNSRFDCAPDKGITPQQCEARGCCYMPAEWPPDAQMGQPWCFFPPSYPSYRLENLTTTETGYTATLTRAVPTFFPKDIMTLRLDMLMETESRLHFTIKDPANRRYEVPLETPRVYSQAPFTLYSVEFSEEPFGVVVRRKLDGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLAEHLGSLMLSTNWTKITLWNRDIAPEPNVNLYGSHPFYLVLEDGGLAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSTSAITRQVVENMTRAYFPLDVQWNDLDYMDARRDFTFNKDHFGDFPAMVQELHQGGRRYIMIVDPAISSSGPAGTYRPYDEGLRRGVFITNETGQPLIGQDMVTEFHAQVPFDGMWIDMNEPSNFVRGSVDGCPDNSLENPPYLPGVVGGTLRAATICASSHQFLSTHYDLHNLYGLTEALASHRALVKARGMRPFVISRSTFAGHGRYSGHWTGDVWSNWEQLSYSVPEILLFNLLGVPLVGADICGFLGNTSEELCVRWTQLGAFYPFMRNHNALNSQPQEPYRFSETAQQAMRKAFTLRYVLLPYLYTLFHRAHVRGETVARPLFLEFPEDPSTWTVDRQLLWGEALLITPVLEAEKVEVTGYFPQGTWYDLQTVPMEAFGSLPPPAPLTSVIHSKGQWVTLSAPLDTINVHLRAGHIIPMQGPALTTTESRKQHMALAVALTASGEAQGELFWDDGESLGVLDGGDYTQLIFLAKNNTFVNKLVHVSSEGASLQLRNVTVLGVATAPQQVLCNSVPVSNFTFSPDTETLAIPVSLTMGEQFVISWS", "length": 916, "header": "tr|A0AAA9SPK2-1|A0AAF6Z2G3_BOVIN Computationally mapped isoform of Lysosomal alpha-glucosidase OS=Bos taurus OX=9913 GN=GAA PE=3 SV=1 CANONICAL=A0AAF6Z2G3-1" }, "locus": { "chromosome": "19", "start_pos": 52496233, "end_pos": 52483938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085860.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085860.1" } ] } }, { "isoform_ac": "A0AAF6Z2G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3/entry", "sequence": { "sequence": "METGKGWGAALTVPLATSSTSEVWVGRAKTFHSEFPKFLNNHHHRCVWQSQVELVHCVIHCPPMMRWPPCSRPLLGVCTLLSLALLGHILLHDLEVVPRELRGFSQDEIHQACQPGASSPECRGSPRAAPTQCDLPPNSRFDCAPDKGITPQQCEARGCCYMPAEWPPDAQMGQPWCFFPPSYPSYRLENLTTTETGYTATLTRAVPTFFPKDIMTLRLDMLMETESRLHFTIKDPANRRYEVPLETPRVYSQAPFTLYSVEFSEEPFGVVVRRKLDGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLAEHLGSLMLSTNWTKITLWNRDIAPEPNVNLYGSHPFYLVLEDGGLAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSTSAITRQVVENMTRAYFPLDVQWNDLDYMDARRDFTFNKDHFGDFPAMVQELHQGGRRYIMIVDPAISSSGPAGTYRPYDEGLRRGVFITNETGQPLIGQVWPGLTAFPDFTNPETLDWWQDMVTEFHAQVPFDGMWIDMNEPSNFVRGSVDGCPDNSLENPPYLPGVVGGTLRAATICASSHQFLSTHYDLHNLYGLTEALASHRALVKARGMRPFVISRSTFAGHGRYSGHWTGDVWSNWEQLSYSVPEILLFNLLGVPLVGADICGFLGNTSEELCVRWTQLGAFYPFMRNHNALNSQPQEPYRFSETAQQAMRKAFTLRYVLLPYLYTLFHRAHVRGETVARPLFLEFPEDPSTWTVDRQLLWGEALLITPVLEAEKVEVTGYFPQGTWYDLQTVPMEAFGSLPPPAPLTSVIHSKGQWVTLSAPLDTINVHLRAGHIIPMQGPALTTTESRKQHMALAVALTASGEAQGELFWDDGESLGVLDGGDYTQLIFLAKNNTFVNKLVHVSSEGASLQLRNVTVLGVATAPQQVLCNSVPVSNFTFSPDTETLAIPVSLTMGEQFVISWS", "length": 1000, "header": "tr|A0AAF6Z2G3-1|A0AAF6Z2G3_BOVIN Isoform 1 of Lysosomal alpha-glucosidase OS=Bos taurus OX=9913 GN=GAA PE=3 SV=1 CANONICAL=A0AAF6Z2G3-1" }, "locus": { "chromosome": "19", "start_pos": 52498404, "end_pos": 52483938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021325.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021325.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021325.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021325.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "alpha-1,4-glucosidase activity", "id": "GO:0004558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004558", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" }, { "name": "glucan 1,6-alpha-glucosidase activity", "id": "GO:0043896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043896", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" }, { "name": "autolysosome lumen", "id": "GO:0120282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120282", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" }, { "name": "glycophagy", "id": "GO:0061723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" }, { "name": "diaphragm contraction", "id": "GO:0002086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002086", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2G3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 702, "end_pos": 704, "annotation": "n_glycosylation_sequon" }, { "start_pos": 930, "end_pos": 932, "annotation": "n_glycosylation_sequon" }, { "start_pos": 951, "end_pos": 953, "annotation": "n_glycosylation_sequon" }, { "start_pos": 973, "end_pos": 975, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2G3" }, { "id": "PS51448", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P-type", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 181, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.20", "ec_name": "Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.", "evidence": [ { "id": "3.2.1.20", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.20" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 440, "end_pos": 442 }, { "start_pos": 520, "end_pos": 522 }, { "start_pos": 702, "end_pos": 704 }, { "start_pos": 930, "end_pos": 932 }, { "start_pos": 951, "end_pos": 953 }, { "start_pos": 973, "end_pos": 975 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZBM9-1", "uniprot_ac": "A0AAF6ZBM9", "uniprot_id": "A0AAF6ZBM9_BOVIN", "mass": { "chemical_mass": 87746.0, "monoisotopic_mass": 87746.0 }, "refseq": {}, "gene_names": [ { "name": "ZFX", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ] } ], "protein_names": [ { "name": "Zinc finger protein X-linked", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFX", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9", "locus": { "chromosome": "X", "start_pos": 119111685, "end_pos": 119149979, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007730", "url": "https://www.ensembl.org/id/ENSBTAG00000007730" } ] } } ], "crossref": [ { "id": "A0AAF6ZBM9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZBM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007730", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007730", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LN80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T512", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T512", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T512-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T512-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEDGLELQPQEPNSFFDTTDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESIHVSDIGHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQEDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAAHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP", "length": 777, "header": "tr|A0AAF6ZBM9-1|A0AAF6ZBM9_BOVIN Isoform 1 of Zinc finger protein X-linked OS=Bos taurus OX=9913 GN=ZFX PE=3 SV=1 CANONICAL=A0AAF6ZBM9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN80/entry", "sequence": { "sequence": "MDEDGLELQPQEPNSFFDTTGADATHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESIHVSDIGHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQEDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAAHEQQMDDNEIKTFMPIAWAAAYAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP", "length": 753, "header": "tr|A0A3Q1LN80-1|A0AAF6ZBM9_BOVIN Computationally mapped isoform of Zinc finger protein X-linked OS=Bos taurus OX=9913 GN=ZFX PE=3 SV=1 CANONICAL=A0AAF6ZBM9-1" }, "locus": { "chromosome": "X", "start_pos": 119133742, "end_pos": 119114586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069631.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069631.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061415.1" } ] } }, { "isoform_ac": "A0AAA9T512-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T512/entry", "sequence": { "sequence": "MDEDGLELQPQEPNSFFDTTVDDAGKIEHDGSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAAHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP", "length": 610, "header": "tr|A0AAA9T512-1|A0AAF6ZBM9_BOVIN Computationally mapped isoform of Zinc finger protein X-linked OS=Bos taurus OX=9913 GN=ZFX PE=3 SV=1 CANONICAL=A0AAF6ZBM9-1" }, "locus": { "chromosome": "X", "start_pos": 119133742, "end_pos": 119114586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133216.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133216.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091807.1" } ] } }, { "isoform_ac": "A0AAA9TGB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB7/entry", "sequence": { "sequence": "MDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESIHVSDIGHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQEDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLSNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP", "length": 723, "header": "tr|A0AAA9TGB7-1|A0AAF6ZBM9_BOVIN Computationally mapped isoform of Zinc finger protein X-linked OS=Bos taurus OX=9913 GN=ZFX PE=3 SV=1 CANONICAL=A0AAF6ZBM9-1" }, "locus": { "chromosome": "X", "start_pos": 119130473, "end_pos": 119114586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095222.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095222.1" } ] } }, { "isoform_ac": "A0AAF6YRH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRH8/entry", "sequence": { "sequence": "MDEDGLELQPQEPNSFFDTTGADATHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESIHVSDIGHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQEDDKGNCEDYLMISCGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAAHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP", "length": 750, "header": "tr|A0AAF6YRH8-1|A0AAF6ZBM9_BOVIN Computationally mapped isoform of Zinc finger protein X-linked OS=Bos taurus OX=9913 GN=ZFX PE=3 SV=1 CANONICAL=A0AAF6ZBM9-1" }, "locus": { "chromosome": "X", "start_pos": 119133742, "end_pos": 119114586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010165.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010165.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010165.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010165.4" } ] } }, { "isoform_ac": "A0AAF6ZBM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9/entry", "sequence": { "sequence": "MDEDGLELQPQEPNSFFDTTDVVDSDITVHNFVPDDPDSVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLASDITSASMSMPEHVLTSESIHVSDIGHVEHVVHDSVVEAEIVTDPLTADVVSEEVLVADCASEAVIDANGIPVDQQEDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDAESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNNSIRVPREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAAHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEHLTKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKEMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRCRKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSEKNQHIMRHHKEVGLP", "length": 777, "header": "tr|A0AAF6ZBM9-1|A0AAF6ZBM9_BOVIN Isoform 1 of Zinc finger protein X-linked OS=Bos taurus OX=9913 GN=ZFX PE=3 SV=1 CANONICAL=A0AAF6ZBM9-1" }, "locus": { "chromosome": "X", "start_pos": 119133742, "end_pos": 119114586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034353.5", "url": "https://www.ensembl.org/id/ENSBTAT00000034353.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034250.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034250.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBM9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 616, "end_pos": 618, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBM9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 397, "end_pos": 427, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 260, "end_pos": 262 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 616, "end_pos": 618 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZQB2-1", "uniprot_ac": "A0AAF6ZQB2", "uniprot_id": "A0AAF6ZQB2_BOVIN", "mass": { "chemical_mass": 24846.0, "monoisotopic_mass": 24846.0 }, "refseq": {}, "gene_names": [ { "name": "NAA10", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ] } ], "protein_names": [ { "name": "N-terminal amino-acid N(alpha)-acetyltransferase NatA", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.255", "type": "synonym", "evidence": [ { "id": "A0AAF6ZQB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAA10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2", "locus": { "chromosome": "X", "start_pos": 37143751, "end_pos": 37149586, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047702", "url": "https://www.ensembl.org/id/ENSBTAG00000047702" } ] } } ], "crossref": [ { "id": "A0AAF6ZQB2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZQB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04301", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04301", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23091", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23091", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23091:SF268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23091:SF268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "50496", "url": "https://www.rhea-db.org/rhea/50496", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50500", "url": "https://www.rhea-db.org/rhea/50500", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50504", "url": "https://www.rhea-db.org/rhea/50504", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50508", "url": "https://www.rhea-db.org/rhea/50508", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50512", "url": "https://www.rhea-db.org/rhea/50512", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50516", "url": "https://www.rhea-db.org/rhea/50516", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SQE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKRISEVEPKYYADGEDAYAMKRDLTQMADELRRHLELKEKGRHVVLGSIENKMEGKGNSLPSSGEACREEKGLVAEDSGGDSKDLSEVSETTESTDVKDSSEASDSAS", "length": 220, "header": "tr|A0AAF6ZQB2-1|A0AAF6ZQB2_BOVIN Isoform 1 of N-terminal amino-acid N(alpha)-acetyltransferase NatA OS=Bos taurus OX=9913 GN=NAA10 PE=3 SV=1 CANONICAL=A0AAF6ZQB2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQE5/entry", "sequence": { "sequence": "MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALHLYSNTLNFQISEVEPKYYADGEDAYAMKRDLTQMADELRRHLELKEKGRHVVLGSIENKMEGKGNSLPSSGEACREEKGLVAEDSGGDSKDLSEAPAT", "length": 218, "header": "tr|A0AAA9SQE5-1|A0AAF6ZQB2_BOVIN Computationally mapped isoform of N-terminal amino-acid N(alpha)-acetyltransferase NatA OS=Bos taurus OX=9913 GN=NAA10 PE=3 SV=1 CANONICAL=A0AAF6ZQB2-1" }, "locus": { "chromosome": "X", "start_pos": 37149480, "end_pos": 37143970, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089115.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089115.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085161.1" } ] } }, { "isoform_ac": "A0AAF6ZQB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2/entry", "sequence": { "sequence": "MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKRISEVEPKYYADGEDAYAMKRDLTQMADELRRHLELKEKGRHVVLGSIENKMEGKGNSLPSSGEACREEKGLVAEDSGGDSKDLSEVSETTESTDVKDSSEASDSAS", "length": 220, "header": "tr|A0AAF6ZQB2-1|A0AAF6ZQB2_BOVIN Isoform 1 of N-terminal amino-acid N(alpha)-acetyltransferase NatA OS=Bos taurus OX=9913 GN=NAA10 PE=3 SV=1 CANONICAL=A0AAF6ZQB2-1" }, "locus": { "chromosome": "X", "start_pos": 37149480, "end_pos": 37145007, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064306.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064306.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055621.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055621.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" }, { "name": "NatA complex", "id": "GO:0031415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031415", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-N-terminal amino-acid acetyltransferase activity", "id": "GO:0004596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004596", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" }, { "name": "negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric", "id": "GO:2000719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000719", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" }, { "name": "positive regulation of protein refolding", "id": "GO:1904592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904592", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "50496", "name": "", "equation": "N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZQB2-1", "Q2KI14-1", "E1BIH2-1" ], "evidence": [ { "id": "50496", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50496" } ] }, { "id": "50500", "name": "", "equation": "N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZQB2-1", "Q2KI14-1", "E1BIH2-1" ], "evidence": [ { "id": "50500", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50500" } ] }, { "id": "50504", "name": "", "equation": "N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZQB2-1", "Q2KI14-1", "E1BIH2-1" ], "evidence": [ { "id": "50504", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50504" } ] }, { "id": "50508", "name": "", "equation": "N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZQB2-1", "Q2KI14-1", "E1BIH2-1" ], "evidence": [ { "id": "50508", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50508" } ] }, { "id": "50512", "name": "", "equation": "N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZQB2-1", "Q2KI14-1", "E1BIH2-1" ], "evidence": [ { "id": "50512", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50512" } ] }, { "id": "50516", "name": "", "equation": "N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZQB2-1", "Q2KI14-1", "E1BIH2-1" ], "evidence": [ { "id": "50516", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50516" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZQB2", "gene_name": "NAA10", "activity": [ { "ec_number": "2.3.1.255", "activity": "N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+).", "evidence": [ { "id": "A0AAF6ZQB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ] }, { "ec_number": "2.3.1.255", "activity": "", "evidence": [ { "id": "A0AAF6ZQB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" } ] } ] }, { "uniprot_ac": "E1BIH2", "gene_name": "NAA11", "activity": [ { "ec_number": "2.3.1.255", "activity": "N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+).", "evidence": [ { "id": "E1BIH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH2" } ] }, { "ec_number": "2.3.1.255", "activity": "", "evidence": [ { "id": "E1BIH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH2" } ] } ] }, { "uniprot_ac": "Q2KI14", "gene_name": "NAA10", "activity": [ { "ec_number": "2.3.1.255", "activity": "N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+).", "evidence": [ { "id": "Q2KI14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI14" } ] }, { "ec_number": "2.3.1.255", "activity": "", "evidence": [ { "id": "Q2KI14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI14" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZQB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQB2" }, { "id": "PS51186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "N-acetyltransferase", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 137, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.1.255", "ec_name": "N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+).", "evidence": [ { "id": "2.3.1.255", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.255" }, { "id": "2.3.1.255", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.255" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1T1-1", "uniprot_ac": "A0AAF6Z1T1", "uniprot_id": "A0AAF6Z1T1_BOVIN", "mass": { "chemical_mass": 39276.0, "monoisotopic_mass": 39276.0 }, "refseq": {}, "gene_names": [ { "name": "COQ5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ] } ], "protein_names": [ { "name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.201", "type": "synonym", "evidence": [ { "id": "A0AAF6Z1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1/entry#names_and_taxonomy" } ] }, { "name": "Ubiquinone biosynthesis methyltransferase COQ5", "type": "synonym", "evidence": [ { "id": "A0AAF6Z1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Methyltransferase required for the conversion of 2-decaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST89#function" }, { "database": "HAMAP", "id": "MF_03191", "url": "https://hamap.expasy.org/signature/MF_03191" }, { "database": "UniProtKB", "id": "ARBA00058208", "url": "https://www.uniprot.org/uniprotkb/ARBA00058208#function" }, { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1", "locus": { "chromosome": "17", "start_pos": 62796288, "end_pos": 62813512, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015761", "url": "https://www.ensembl.org/id/ENSBTAG00000015761" } ] } } ], "crossref": [ { "id": "A0AAF6Z1T1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1T1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43591", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43591", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43591:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43591:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "44764", "url": "https://www.rhea-db.org/rhea/44764", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9ST89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1T1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRYVLSDSGHPTVKMAAPRSWALWSFCGCGWSRAVSGCRLPGLRSSSPRGPLGARLLSQEKEATETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMRPFPGTQLLDVAGGTGDIAFRFLNYVQAQHQRKQKRQLRAQQNLSWEEIARKYQNEEDSLGGSHVMVCDINKEMLKIGKQKARAQGYKAGLAWILGDAEELPFDDNKFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLLSRLYDVYSFQVIPVLGEVIAGDWKSYQYLVESIRQFPSQEEFKEMIEDAGFQKVTYENLTSGIVAIHSGFKLYLR", "length": 345, "header": "tr|A0AAF6Z1T1-1|A0AAF6Z1T1_BOVIN Isoform 1 of 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Bos taurus OX=9913 GN=COQ5 PE=3 SV=1 CANONICAL=A0AAF6Z1T1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST89/entry", "sequence": { "sequence": "MAAPRSWALWSFCGCGWSRAVSGCRLPGLRSSSPRGPLGARLLSQEKEATETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMRPFPGTQLLDVAGGTGLAWILGDAEELPFDDNKFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLLSRLYDVYSFQVIPVLGEVIAGDWKSYQYLVESIRQFPSQEEFKEMIEDAGFQKVTYENLTSGIVAIHSGFKLYLR", "length": 256, "header": "tr|A0AAA9ST89-1|A0AAF6Z1T1_BOVIN Computationally mapped isoform of 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Bos taurus OX=9913 GN=COQ5 PE=3 SV=1 CANONICAL=A0AAF6Z1T1-1" }, "locus": { "chromosome": "17", "start_pos": 62813372, "end_pos": 62796802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126015.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126015.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088567.1" } ] } }, { "isoform_ac": "A0AAF6Z1T1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1/entry", "sequence": { "sequence": "MLRYVLSDSGHPTVKMAAPRSWALWSFCGCGWSRAVSGCRLPGLRSSSPRGPLGARLLSQEKEATETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMRPFPGTQLLDVAGGTGDIAFRFLNYVQAQHQRKQKRQLRAQQNLSWEEIARKYQNEEDSLGGSHVMVCDINKEMLKIGKQKARAQGYKAGLAWILGDAEELPFDDNKFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLLSRLYDVYSFQVIPVLGEVIAGDWKSYQYLVESIRQFPSQEEFKEMIEDAGFQKVTYENLTSGIVAIHSGFKLYLR", "length": 345, "header": "tr|A0AAF6Z1T1-1|A0AAF6Z1T1_BOVIN Isoform 1 of 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Bos taurus OX=9913 GN=COQ5 PE=3 SV=1 CANONICAL=A0AAF6Z1T1-1" }, "locus": { "chromosome": "17", "start_pos": 62813417, "end_pos": 62796802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020929.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020929.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020929.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020929.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extrinsic component of mitochondrial inner membrane", "id": "GO:0031314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031314", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity", "id": "GO:0008425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008425", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1T1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "44764", "name": "", "equation": "2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5A2-1", "A0AAF6Z1T1-1" ], "evidence": [ { "id": "44764", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44764" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z1T1", "gene_name": "COQ5", "activity": [ { "ec_number": "2.1.1.201", "activity": "2-methoxy-6-(all-trans-nonaprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0AAF6Z1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ] }, { "ec_number": "2.1.1.201", "activity": "", "evidence": [ { "id": "A0AAF6Z1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T1" } ] } ] }, { "uniprot_ac": "Q0P5A2", "gene_name": "COQ5", "activity": [ { "ec_number": "2.1.1.201", "activity": "2-methoxy-6-(all-trans-nonaprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q0P5A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5A2" } ] }, { "ec_number": "2.1.1.201", "activity": "", "evidence": [ { "id": "Q0P5A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5A2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.201", "ec_name": "2-methoxy-6-(all-trans-nonaprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.201", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201" }, { "id": "2.1.1.201", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.201" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 328, "end_pos": 330 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZIA4-1", "uniprot_ac": "A0AAF6ZIA4", "uniprot_id": "A0AAF6ZIA4_BOVIN", "mass": { "chemical_mass": 44973.0, "monoisotopic_mass": 44973.0 }, "refseq": {}, "gene_names": [ { "name": "CKB", "type": "recommended", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] } ], "protein_names": [ { "name": "Creatine kinase B-type", "type": "recommended", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4/entry#names_and_taxonomy" } ] }, { "name": "2.7.3.2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4/entry#names_and_taxonomy" } ] }, { "name": "Creatine kinase B chain", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4/entry#names_and_taxonomy" } ] }, { "name": "Creatine phosphokinase M-type", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4#function" }, { "database": "UniProtKB", "id": "ARBA00045554", "url": "https://www.uniprot.org/uniprotkb/ARBA00045554#function" }, { "database": "UniProtKB", "id": "A0AAA9SUZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4", "locus": { "chromosome": "21", "start_pos": 68158057, "end_pos": 68167770, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035998", "url": "https://www.ensembl.org/id/ENSBTAG00000035998" } ] } } ], "crossref": [ { "id": "A0AAF6ZIA4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZIA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11547", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11547:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17157", "url": "https://www.rhea-db.org/rhea/17157", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SUZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFSNSHNTLKLRFPAEDEFPDLSGHNNHMAKVLTPELYAELRAKSTPSGFTVDDVIQTGVDNPGHPYIMTVGCVAGDEESYDVFKELFDPIIEDRHGGYKPTDEHKTDLNPDNLQVRGGPGRGAGWVGGLPSAQPLGPQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCNGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFPEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK", "length": 405, "header": "tr|A0AAF6ZIA4-1|A0AAF6ZIA4_BOVIN Isoform 1 of Creatine kinase B-type OS=Bos taurus OX=9913 GN=CKB PE=3 SV=1 CANONICAL=A0AAF6ZIA4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ5/entry", "sequence": { "sequence": "MPAAAMPFSNSHNTLKLRFPAEDEFPDLSGHNNHMAKVLTPELYAELRAKSTPSGFTVDDVIQTGVDNPGHPYIMTVGCVAGDEESYDVFKELFDPIIEDRHGGYKPTDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCNGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFPEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK", "length": 386, "header": "tr|A0AAA9SUZ5-1|A0AAF6ZIA4_BOVIN Computationally mapped isoform of Creatine kinase B-type OS=Bos taurus OX=9913 GN=CKB PE=3 SV=1 CANONICAL=A0AAF6ZIA4-1" }, "locus": { "chromosome": "21", "start_pos": 68167334, "end_pos": 68158273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089230.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089230.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089162.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089162.1" } ] } }, { "isoform_ac": "A0AAF6ZIA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4/entry", "sequence": { "sequence": "MPFSNSHNTLKLRFPAEDEFPDLSGHNNHMAKVLTPELYAELRAKSTPSGFTVDDVIQTGVDNPGHPYIMTVGCVAGDEESYDVFKELFDPIIEDRHGGYKPTDEHKTDLNPDNLQVRGGPGRGAGWVGGLPSAQPLGPQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCNGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFPEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK", "length": 405, "header": "tr|A0AAF6ZIA4-1|A0AAF6ZIA4_BOVIN Isoform 1 of Creatine kinase B-type OS=Bos taurus OX=9913 GN=CKB PE=3 SV=1 CANONICAL=A0AAF6ZIA4-1" }, "locus": { "chromosome": "21", "start_pos": 68160915, "end_pos": 68158273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050490.3", "url": "https://www.ensembl.org/id/ENSBTAT00000050490.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047181.2", "url": "https://www.ensembl.org/id/ENSBTAP00000047181.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phosphocreatine biosynthetic process", "id": "GO:0046314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046314", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" }, { "name": "futile creatine cycle", "id": "GO:0140651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140651", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "creatine kinase activity", "id": "GO:0004111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004111", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17157", "name": "", "equation": "creatine + ATP = N-phosphocreatine + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZIA4-1", "Q5EA61-1", "Q9TTK8-1", "Q9XSC6-1", "Q3ZBP1-1" ], "evidence": [ { "id": "17157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZIA4", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] } ] }, { "uniprot_ac": "Q3ZBP1", "gene_name": "CKMT2", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] } ] }, { "uniprot_ac": "Q5EA61", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] } ] }, { "uniprot_ac": "Q9TTK8", "gene_name": "CKMT1", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] } ] }, { "uniprot_ac": "Q9XSC6", "gene_name": "CKM", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" }, { "id": "PS51510", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51510" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase C-terminal", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 391, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" }, { "id": "PS51509", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51509" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase N-terminal", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 98, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.3.2", "ec_name": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "2.7.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2" }, { "id": "2.7.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.3.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 246, "end_pos": 248 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1P0-1", "uniprot_ac": "A0AAF6Z1P0", "uniprot_id": "A0AAF6Z1P0_BOVIN", "mass": { "chemical_mass": 48439.0, "monoisotopic_mass": 48439.0 }, "refseq": { "ac": "XP_015314058", "name": "GTPase Era, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314058" }, "gene_names": [ { "name": "ERAL1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ] }, { "name": "ERAL1", "type": "synonym", "evidence": [ { "id": "XP_015314058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314058" } ] } ], "protein_names": [ { "name": "GTPase Era, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0/entry#names_and_taxonomy" } ] }, { "name": "ERA-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z1P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0/entry#names_and_taxonomy" } ] }, { "name": "GTPase Era, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015314058", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314058" } ] } ], "function": [ { "annotation": "Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZY4#function" }, { "database": "UniProtKB", "id": "ARBA00025227", "url": "https://www.uniprot.org/uniprotkb/ARBA00025227#function" }, { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ERAL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0", "locus": { "chromosome": "19", "start_pos": 20238641, "end_pos": 20233860, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015639", "url": "https://www.ensembl.org/id/ENSBTAG00000015639" } ] } } ], "crossref": [ { "id": "A0AAF6Z1P0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1P0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22534", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22534", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523344", "url": "https://www.ncbi.nlm.nih.gov/gene/523344", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42698", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42698", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42698:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42698:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015314058", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314058", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1P0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASSWRGAVLLRTVSGLWQAGPDAAREWMTRLPSLLGFQQRCVSCVAGPAFSGPRLASASRPNGQNSALDCFLGLSQPDNSLPFRVPAVSVHRDEQDLLLVHRPDMPENPRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSKKVHTTRSQALGVITEKETQVILLDTPGLISPAKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQVLRCLTQFSQVPSILVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKTKQALRSRPDTHCPSPAAQGPNPQPVRDPQQMGWPHFQEIFMLSALSQEDVKTLKQYLLAQARPGPWEFHSEVLTSQTPEEICANMIREKLLEYLPEEVPYNVQQKTVVWDEGPSGELVIEQKLLVSKESHMILIGPKGYLIAQIAQEVGRDLMNIFLCEVQLRLSVKLLK", "length": 436, "header": "tr|A0AAF6Z1P0-1|A0AAF6Z1P0_BOVIN Isoform 1 of GTPase Era, mitochondrial OS=Bos taurus OX=9913 GN=ERAL1 PE=3 SV=1 CANONICAL=A0AAF6Z1P0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZY4/entry", "sequence": { "sequence": "MAASSWRGAVLLRTVSGLWQAGPDAAREWMTRLPSLLGFQQRCVSCVAGPAFSGPRLASASRPNGQNSALDCFLGLSQPDNSLPFRVPAVSVHRDEQDLLLVHRPDMPENPRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSKKVHTTRSQALGVITEKETQVILLDTPGLISPAKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQVLRCLTQFSQVPSILVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKTKQALRSRPDTHCPSPAAQGPNPQPVRDPQQMGWPHFQEIFMLSALSQEDVKTLKQYLLAQARPGPWEFHSEVLTSQTPEEICANMIREKLLEYLPEEVPYNVQQKILIGPKGYLIAQIAQEVGRDLMNIFLCEVQLRLSVKLLK", "length": 410, "header": "tr|A0AAA9SZY4-1|A0AAF6Z1P0_BOVIN Computationally mapped isoform of GTPase Era, mitochondrial OS=Bos taurus OX=9913 GN=ERAL1 PE=3 SV=1 CANONICAL=A0AAF6Z1P0-1" }, "locus": { "chromosome": "19", "start_pos": 20237890, "end_pos": 20233874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127425.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127425.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090980.1" } ] } }, { "isoform_ac": "A0AAF6Z1P0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0/entry", "sequence": { "sequence": "MAASSWRGAVLLRTVSGLWQAGPDAAREWMTRLPSLLGFQQRCVSCVAGPAFSGPRLASASRPNGQNSALDCFLGLSQPDNSLPFRVPAVSVHRDEQDLLLVHRPDMPENPRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSKKVHTTRSQALGVITEKETQVILLDTPGLISPAKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQVLRCLTQFSQVPSILVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKTKQALRSRPDTHCPSPAAQGPNPQPVRDPQQMGWPHFQEIFMLSALSQEDVKTLKQYLLAQARPGPWEFHSEVLTSQTPEEICANMIREKLLEYLPEEVPYNVQQKTVVWDEGPSGELVIEQKLLVSKESHMILIGPKGYLIAQIAQEVGRDLMNIFLCEVQLRLSVKLLK", "length": 436, "header": "tr|A0AAF6Z1P0-1|A0AAF6Z1P0_BOVIN Isoform 1 of GTPase Era, mitochondrial OS=Bos taurus OX=9913 GN=ERAL1 PE=3 SV=1 CANONICAL=A0AAF6Z1P0-1" }, "locus": { "chromosome": "19", "start_pos": 20237890, "end_pos": 20233874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020770.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020770.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020770.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020770.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" }, { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" }, { "name": "RNA folding chaperone", "id": "GO:0140691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140691", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial small ribosomal subunit assembly", "id": "GO:0180026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1P0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z1P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1P0" }, { "id": "PS51713", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51713" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Era-type G", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 330, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z5M1-1", "uniprot_ac": "A0AAF6Z5M1", "uniprot_id": "A0AAF6Z5M1_BOVIN", "mass": { "chemical_mass": 38579.0, "monoisotopic_mass": 38579.0 }, "refseq": {}, "gene_names": [ { "name": "RABGGTB", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] } ], "protein_names": [ { "name": "Geranylgeranyl transferase type-2 subunit beta", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.60", "type": "synonym", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3Z8#function" }, { "database": "UniProtKB", "id": "RU365076", "url": "https://www.uniprot.org/uniprotkb/RU365076#function" }, { "database": "UniProtKB", "id": "ARBA00094457", "url": "https://www.uniprot.org/uniprotkb/ARBA00094457#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABGGTB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1", "locus": { "chromosome": "3", "start_pos": 69056998, "end_pos": 69065985, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018447", "url": "https://www.ensembl.org/id/ENSBTAG00000018447" } ] } } ], "crossref": [ { "id": "A0AAF6Z5M1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z5M1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02894", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02894", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "21240", "url": "https://www.rhea-db.org/rhea/21240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T3Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWQGIYGSKSLELLMGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILTFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDINKVVEYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLRRVNVQPELVS", "length": 345, "header": "tr|A0AAF6Z5M1-1|A0AAF6Z5M1_BOVIN Isoform 1 of Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus OX=9913 GN=RABGGTB PE=3 SV=1 CANONICAL=A0AAF6Z5M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3Z8/entry", "sequence": { "sequence": "MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILTFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDINKVVEYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMANPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLRRVNVQPELVS", "length": 331, "header": "tr|A0AAA9T3Z8-1|A0AAF6Z5M1_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus OX=9913 GN=RABGGTB PE=3 SV=1 CANONICAL=A0AAF6Z5M1-1" }, "locus": { "chromosome": "3", "start_pos": 69065967, "end_pos": 69058002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117536.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117536.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092515.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092515.1" } ] } }, { "isoform_ac": "A0AAA9TKJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKJ3/entry", "sequence": { "sequence": "MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILTFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDINKVVEYVQSLQKEDGSFAGDIWGNVFNPWHLEYQYK", "length": 152, "header": "tr|A0AAA9TKJ3-1|A0AAF6Z5M1_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus OX=9913 GN=RABGGTB PE=3 SV=1 CANONICAL=A0AAF6Z5M1-1" }, "locus": { "chromosome": "3", "start_pos": 69065967, "end_pos": 69062442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091457.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091457.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096787.1" } ] } }, { "isoform_ac": "A0AAF6Z5M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1/entry", "sequence": { "sequence": "MWQGIYGSKSLELLMGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILTFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDINKVVEYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLRRVNVQPELVS", "length": 345, "header": "tr|A0AAF6Z5M1-1|A0AAF6Z5M1_BOVIN Isoform 1 of Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus OX=9913 GN=RABGGTB PE=3 SV=1 CANONICAL=A0AAF6Z5M1-1" }, "locus": { "chromosome": "3", "start_pos": 69065657, "end_pos": 69058002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024551.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024551.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024551.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024551.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "Rab geranylgeranyltransferase activity", "id": "GO:0004663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004663", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ], "pmid": "" }, { "name": "protein prenyltransferase activity", "id": "GO:0008318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008318", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Rab-protein geranylgeranyltransferase complex", "id": "GO:0005968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21240", "name": "", "equation": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA80-1", "A0AAF6Z5M1-1", "Q5EAD5-1", "P29702-1", "Q5E9B3-1", "A0AAA9SWU6-1", "A0AAA9S4G1-1" ], "evidence": [ { "id": "21240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21240" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S4G1", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] } ] }, { "uniprot_ac": "A0AAA9SWU6", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] } ] }, { "uniprot_ac": "A0AAF6Z5M1", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] } ] }, { "uniprot_ac": "P29702", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q5EAD5", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" }, { "id": "PF00432", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00432" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Prenyltransferase alpha-alpha toroid", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 329, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.60", "ec_name": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "2.5.1.60", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60" }, { "id": "2.5.1.60", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.60" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCD0-1", "uniprot_ac": "A0AAF6ZCD0", "uniprot_id": "A0AAF6ZCD0_BOVIN", "mass": { "chemical_mass": 50744.0, "monoisotopic_mass": 50744.0 }, "refseq": {}, "gene_names": [ { "name": "CDC37", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ] } ], "protein_names": [ { "name": "Hsp90 co-chaperone Cdc37", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0/entry#names_and_taxonomy" } ] }, { "name": "Hsp90 chaperone protein kinase-targeting subunit", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M4#function" }, { "database": "UniProtKB", "id": "RU369110", "url": "https://www.uniprot.org/uniprotkb/RU369110#function" }, { "database": "UniProtKB", "id": "A0AAA9TW40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW40#function" }, { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC37", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0", "locus": { "chromosome": "7", "start_pos": 14926956, "end_pos": 14950522, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011699", "url": "https://www.ensembl.org/id/ENSBTAG00000011699" } ] } } ], "crossref": [ { "id": "A0AAF6ZCD0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCD0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004918", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004918", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12800", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12800", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12800:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12800:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03234", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03234", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08565", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08565", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T5M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKAPVRGHACHAHATLMCTAPSSPPLWMGWALRPRPARPRSRRPAAAALPQPTPLLASPQSMVNTKPEQAEEESEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKDRVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDAKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSSEAKDGEEAGTGDPLLEATSKSGDEKDVSV", "length": 438, "header": "tr|A0AAF6ZCD0-1|A0AAF6ZCD0_BOVIN Isoform 1 of Hsp90 co-chaperone Cdc37 OS=Bos taurus OX=9913 GN=CDC37 PE=3 SV=1 CANONICAL=A0AAF6ZCD0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M4/entry", "sequence": { "sequence": "MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEQAEEESEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKDRVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDAKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSSEAKDGEEAGTGDPLLEATSKSGDEKDVSV", "length": 368, "header": "tr|A0AAA9T5M4-1|A0AAF6ZCD0_BOVIN Computationally mapped isoform of Hsp90 co-chaperone Cdc37 OS=Bos taurus OX=9913 GN=CDC37 PE=3 SV=1 CANONICAL=A0AAF6ZCD0-1" }, "locus": { "chromosome": "7", "start_pos": 14938087, "end_pos": 14927359, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121705.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121705.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094074.1" } ] } }, { "isoform_ac": "A0AAA9TW40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW40/entry", "sequence": { "sequence": "MWRPFGLRALRAVRVAALLDTDGGPRLPPQLPEPWRAGPRGKMVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEQAEEESEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKDRVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDAKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSSEAKDGEEAGTGDPLLEATSKSGDEKDVSV", "length": 422, "header": "tr|A0AAA9TW40-1|A0AAF6ZCD0_BOVIN Computationally mapped isoform of Hsp90 co-chaperone Cdc37 OS=Bos taurus OX=9913 GN=CDC37 PE=3 SV=1 CANONICAL=A0AAF6ZCD0-1" }, "locus": { "chromosome": "7", "start_pos": 14950394, "end_pos": 14927359, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099883.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099883.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102832.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102832.1" } ] } }, { "isoform_ac": "A0AAF6ZCD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0/entry", "sequence": { "sequence": "MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKAPVRGHACHAHATLMCTAPSSPPLWMGWALRPRPARPRSRRPAAAALPQPTPLLASPQSMVNTKPEQAEEESEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKDRVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDAKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSSEAKDGEEAGTGDPLLEATSKSGDEKDVSV", "length": 438, "header": "tr|A0AAF6ZCD0-1|A0AAF6ZCD0_BOVIN Isoform 1 of Hsp90 co-chaperone Cdc37 OS=Bos taurus OX=9913 GN=CDC37 PE=3 SV=1 CANONICAL=A0AAF6ZCD0-1" }, "locus": { "chromosome": "7", "start_pos": 14938087, "end_pos": 14927359, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036173.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036173.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036036.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036036.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 179, "start_aa": "Thr", "end_pos": 179, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr179", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "HSP90-CDC37 chaperone complex", "id": "GO:1990565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990565", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "heat shock protein binding", "id": "GO:0031072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "protein kinase regulator activity", "id": "GO:0019887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "scaffold protein binding", "id": "GO:0097110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "Hsp90 protein binding", "id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "post-transcriptional regulation of gene expression", "id": "GO:0010608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010608", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" }, { "name": "positive regulation of type 2 mitophagy", "id": "GO:1905091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905091", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCD0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" }, { "id": "SM01069", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01069" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cdc37 C-terminal", "eco_id": "ECO_0000259", "start_pos": 346, "end_pos": 438, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" }, { "id": "SM01070", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01070" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cdc37 Hsp90 binding", "eco_id": "ECO_0000259", "start_pos": 184, "end_pos": 342, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCD0" }, { "id": "SM01071", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01071" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cdc37 N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 129, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 179 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z814-1", "uniprot_ac": "A0AAF6Z814", "uniprot_id": "A0AAF6Z814_BOVIN", "mass": { "chemical_mass": 92003.0, "monoisotopic_mass": 92003.0 }, "refseq": { "ac": "XP_024832905", "name": "autophagy-related protein 9A isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832905" }, "gene_names": [ { "name": "ATG9A", "type": "recommended", "evidence": [ { "id": "A0AAF6Z814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ] }, { "name": "ATG9A", "type": "synonym", "evidence": [ { "id": "XP_024832905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832905" } ] }, { "name": "ATG9", "type": "synonym", "evidence": [ { "id": "XP_024832905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832905" } ] } ], "protein_names": [ { "name": "Autophagy-related protein 9", "type": "recommended", "evidence": [ { "id": "A0AAF6Z814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814/entry#names_and_taxonomy" } ] }, { "name": "autophagy-related protein 9A isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024832905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832905" } ] } ], "function": [ { "annotation": "Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T608", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T608#function" }, { "database": "UniProtKB", "id": "ARBA00045832", "url": "https://www.uniprot.org/uniprotkb/ARBA00045832#function" }, { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814#function" } ] }, { "annotation": "Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T608", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T608#function" }, { "database": "UniProtKB", "id": "RU364027", "url": "https://www.uniprot.org/uniprotkb/RU364027#function" }, { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATG9A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814", "locus": { "chromosome": "2", "start_pos": 107170286, "end_pos": 107179938, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020608", "url": "https://www.ensembl.org/id/ENSBTAG00000020608" } ] } } ], "crossref": [ { "id": "A0AAF6Z814", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z814", "database": "AlphaFoldDB", "categories": [] }, { "id": "540482", "url": "https://www.ncbi.nlm.nih.gov/gene/540482", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13038:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13038:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04109", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04109", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024832905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38571", "url": "https://www.rhea-db.org/rhea/38571", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38663", "url": "https://www.rhea-db.org/rhea/38663", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38895", "url": "https://www.rhea-db.org/rhea/38895", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T608", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T608", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T608-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T608-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z814-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLRGASHLGTTSKILTSSSLEFIIYTRRMVSLVCSSGRSLSSYRTPSAQLPRQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWVHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNCAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLQPGQAPTGRAPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQAQAEPERHVWHRRESDESGESAPEEGGEGARATQPIPRSASYPCAAPRPGAPETTALQGGFQRRYGGITDPGTVPRAPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV", "length": 821, "header": "tr|A0AAF6Z814-1|A0AAF6Z814_BOVIN Isoform 1 of Autophagy-related protein 9 OS=Bos taurus OX=9913 GN=ATG9A PE=3 SV=1 CANONICAL=A0AAF6Z814-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T608-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T608/entry", "sequence": { "sequence": "MFLRGASFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWVHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNCAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLQPGQAPTGRAPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQAQAEPERHVWHRRESDESGESAPEEGGEGARATQPIPRSASYPCAAPRPGAPETTALQGGFQRRYGGITDPGTVPRAPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV", "length": 774, "header": "tr|A0AAA9T608-1|A0AAF6Z814_BOVIN Computationally mapped isoform of Autophagy-related protein 9 OS=Bos taurus OX=9913 GN=ATG9A PE=3 SV=1 CANONICAL=A0AAF6Z814-1" }, "locus": { "chromosome": "2", "start_pos": 107178020, "end_pos": 107171416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087980.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087980.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091202.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091202.1" } ] } }, { "isoform_ac": "A0AAF6Z814-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814/entry", "sequence": { "sequence": "MFLRGASHLGTTSKILTSSSLEFIIYTRRMVSLVCSSGRSLSSYRTPSAQLPRQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWVHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNCAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLQPGQAPTGRAPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQAQAEPERHVWHRRESDESGESAPEEGGEGARATQPIPRSASYPCAAPRPGAPETTALQGGFQRRYGGITDPGTVPRAPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV", "length": 821, "header": "tr|A0AAF6Z814-1|A0AAF6Z814_BOVIN Isoform 1 of Autophagy-related protein 9 OS=Bos taurus OX=9913 GN=ATG9A PE=3 SV=1 CANONICAL=A0AAF6Z814-1" }, "locus": { "chromosome": "2", "start_pos": 107178020, "end_pos": 107171416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027461.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027461.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027461.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027461.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "bone morphogenesis", "id": "GO:0060349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060349", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" }, { "name": "programmed necrotic cell death", "id": "GO:0097300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097300", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phospholipid scramblase activity", "id": "GO:0017128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z814", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z814" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38571", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38571", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38571" } ] }, { "id": "38663", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MUP9-1" ], "evidence": [ { "id": "38663", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38663" } ] }, { "id": "38895", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38895", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38895" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 489, "end_pos": 491 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZL73-1", "uniprot_ac": "A0AAF6ZL73", "uniprot_id": "A0AAF6ZL73_BOVIN", "mass": { "chemical_mass": 105326.0, "monoisotopic_mass": 105326.0 }, "refseq": {}, "gene_names": [ { "name": "MTHFD1L", "type": "recommended", "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ] } ], "protein_names": [ { "name": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73/entry#names_and_taxonomy" } ] }, { "name": "6.3.4.3", "type": "synonym", "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73/entry#names_and_taxonomy" } ] }, { "name": "Formyltetrahydrofolate synthetase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73#function" }, { "database": "UniProtKB", "id": "ARBA00058670", "url": "https://www.uniprot.org/uniprotkb/ARBA00058670#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTHFD1L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73", "locus": { "chromosome": "9", "start_pos": 88160303, "end_pos": 87978427, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009846", "url": "https://www.ensembl.org/id/ENSBTAG00000009846" } ] } } ], "crossref": [ { "id": "A0AAF6ZL73", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZL73", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00477", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00477", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05212", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05212", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48099:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48099:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02882", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02882", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "20221", "url": "https://www.rhea-db.org/rhea/20221", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TCA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZL73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSARLPFVLRRLARPQHPGSPRRLPSLCRASSGRGSGCGGGEGLLGQQRLRDTQAGSSRGPGSPAPPARDSIVREVIQNSKEVLSLLQEKTPTFKPVLAIIQAGDDNLMQEVNQNLAEEAGLNITHICLPAESGEDEIIDEILKINEDSRVHGLALQIAETSFSNKILNALKPEKDVDGLTDVNLGKLVRGDAHECFISPVARAVIELLEKSVGVSLDGKKILVIGAHGSLEATLQCLFQRKGSMTMSSQWKTPQLQGKLQEADIVVLGSPKPEEIPLSWIQPGTTVFNCSHDFLSGKAACISSGVHGISPIAEDVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRAQTPKAVEILAKEIGLLADEIEIYGKSKAKVRLSLLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDARILHENTQTDKALYNRLVPSVNGVREFSKIQLARLKRLGINKTDPSALTEEEMRKFARLDIDPSTITWQRVVDTNDRFLRKITIGQANTEKGCSRQAQFDIAVASEIMAVLALTDSLSDMKERLGRMVVASDRNGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEGGFVVTEAGFGADIGMEKFFNIKCRASGLVPSVVVLVATVRALKMHGGGPSVTAGVPLRKEYTEENLQLVADGCCNLEKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFNAVPCYHWSIGGKGSVDLAWAVREAASKESRFQFLYDVQLPIVEKIRTIAQSVYGAKDIELSPEAQSKIDRYTEQGFGNLPICMAKTHLSLSHQPDKKGVPKGFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKGLF", "length": 976, "header": "tr|A0AAF6ZL73-1|A0AAF6ZL73_BOVIN Isoform 1 of Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD1L PE=3 SV=1 CANONICAL=A0AAF6ZL73-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA7/entry", "sequence": { "sequence": "MSARLPFVLRRLARPQHPGSPRRLPSLCRASSGRGSGCGGGEGLLGQQRLRDTQAGSSRGPGSPAPPARDSIVREVIQNSKEVLSLLQEKTPTFKPVLAIIQAGDDNLMQEVNQNLAEEAGLNITHICLPAESGEDEIIDEILKINEDSRVHGLALQIAETSFSNKILNALKPEKDVDGLTDVNLGKLVRGDAHECFISPVARAVIELLEKSGVSLDGKKILVIGAHGSLEATLQCLFQRKGSMTMSSQWKTPQLQGKLQEADIVVLGSPKPEEIPLSWIQPGTTVFNCSHDFLSGKAACISSGVHGISPIAEDVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRAQTPKAVEILAKEIGLLADEIEIYGKSKAKVRLSLLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDARILHENTQTDKALYNRLVPSVNGVREFSKIQLARLKRLGINKTDPSALTEEEMRKFARLDIDPSTITWQRVVDTNDRFLRKITIGQANTEKGCSRQAQFDIAVASEIMAVLALTDSLSDMKERLGRMVVASDRNGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEGGFVVTEAGFGADIGMEKFFNIKCRASGLVPSVVVLVATVRALKMHGGGPSVTAGVPLRKEYTEENLQLVADGCCNLEKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFNAVPCYHWSIGGKGSVDLAWAVREAASKESRFQFLYDVQSFPASGSFPVSRLFASASNCGKDKNHCPVCLWSQRY", "length": 895, "header": "tr|A0AAA9TCA7-1|A0AAF6ZL73_BOVIN Computationally mapped isoform of Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD1L PE=3 SV=1 CANONICAL=A0AAF6ZL73-1" }, "locus": { "chromosome": "9", "start_pos": 88105261, "end_pos": 87978608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122053.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122053.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095691.1" } ] } }, { "isoform_ac": "A0AAA9TZ74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ74/entry", "sequence": { "sequence": "MLLFPPSSGHFAASGLQAGDDNLMQEVNQNLAEEAGLNITHICLPAESGEDEIIDEILKINEDSRVHGLALQIAETSFSNKILNALKPEKDVDGLTDVNLGKLVRGDAHECFISPVARAVIELLEKSGVSLDGKKILVIGAHGSLEATLQCLFQRKGSMTMSSQWKTPQLQGKLQEADIVVLGSPKPEEIPLSWIQPGTTVFNCSHDFLSGKAACISSGVHGISPIAEDVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRAQTPKAVEILAKEIGLLADEIEIYGKSKAKVRLSLLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDARILHENTQTDKALYNRLVPSVNGVREFSKIQLARLKRLGINKTDPSALTEEEMRKFARLDIDPSTITWQRVVDTNDRFLRKITIGQANTEKGCSRQAQFDIAVASEIMAVLALTDSLSDMKERLGRMVVASDRNGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEGGFVVTEAGFGADIGMEKFFNIKCRASGLVPSVVVLVATVRALKMHGGGPSVTAGVPLRKEYTEENLQLVADGCCNLEKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFNAVPCYHWSIGGKGSVDLAWAVREAASKESRFQFLYDVQLPIVEKIRTIAQSVYGAKDIELSPEAQSKIDRYTEQGFGNLPICMAKTHLSLSHQPDKKGVPKGFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKGLF", "length": 890, "header": "tr|A0AAA9TZ74-1|A0AAF6ZL73_BOVIN Computationally mapped isoform of Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD1L PE=3 SV=1 CANONICAL=A0AAF6ZL73-1" }, "locus": { "chromosome": "9", "start_pos": 88152876, "end_pos": 87984469, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120961.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120961.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102013.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102013.1" } ] } }, { "isoform_ac": "A0AAF6ZL73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73/entry", "sequence": { "sequence": "MSARLPFVLRRLARPQHPGSPRRLPSLCRASSGRGSGCGGGEGLLGQQRLRDTQAGSSRGPGSPAPPARDSIVREVIQNSKEVLSLLQEKTPTFKPVLAIIQAGDDNLMQEVNQNLAEEAGLNITHICLPAESGEDEIIDEILKINEDSRVHGLALQIAETSFSNKILNALKPEKDVDGLTDVNLGKLVRGDAHECFISPVARAVIELLEKSVGVSLDGKKILVIGAHGSLEATLQCLFQRKGSMTMSSQWKTPQLQGKLQEADIVVLGSPKPEEIPLSWIQPGTTVFNCSHDFLSGKAACISSGVHGISPIAEDVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRAQTPKAVEILAKEIGLLADEIEIYGKSKAKVRLSLLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDARILHENTQTDKALYNRLVPSVNGVREFSKIQLARLKRLGINKTDPSALTEEEMRKFARLDIDPSTITWQRVVDTNDRFLRKITIGQANTEKGCSRQAQFDIAVASEIMAVLALTDSLSDMKERLGRMVVASDRNGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEGGFVVTEAGFGADIGMEKFFNIKCRASGLVPSVVVLVATVRALKMHGGGPSVTAGVPLRKEYTEENLQLVADGCCNLEKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFNAVPCYHWSIGGKGSVDLAWAVREAASKESRFQFLYDVQLPIVEKIRTIAQSVYGAKDIELSPEAQSKIDRYTEQGFGNLPICMAKTHLSLSHQPDKKGVPKGFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQVKGLF", "length": 976, "header": "tr|A0AAF6ZL73-1|A0AAF6ZL73_BOVIN Isoform 1 of Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD1L PE=3 SV=1 CANONICAL=A0AAF6ZL73-1" }, "locus": { "chromosome": "9", "start_pos": 88152876, "end_pos": 87978608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052076.5", "url": "https://www.ensembl.org/id/ENSBTAT00000052076.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052260.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052260.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 421, "start_aa": "Thr", "end_pos": 421, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr421", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "formate-tetrahydrofolate ligase activity", "id": "GO:0004329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004329", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "id": "GO:0004488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004488", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "one-carbon metabolic process", "id": "GO:0006730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "tetrahydrofolate metabolic process", "id": "GO:0046653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046653", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "carboxylic acid biosynthetic process", "id": "GO:0046394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046394", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "10-formyltetrahydrofolate biosynthetic process", "id": "GO:0009257", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009257", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "tetrahydrofolate interconversion", "id": "GO:0035999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035999", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "embryonic neurocranium morphogenesis", "id": "GO:0048702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048702", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "embryonic viscerocranium morphogenesis", "id": "GO:0048703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048703", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "formate biosynthetic process", "id": "GO:0015943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015943", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL73", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20221", "name": "", "equation": "(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCR7-1", "A0AAF6ZL73-1" ], "evidence": [ { "id": "20221", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20221" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZL73", "gene_name": "MTHFD1L", "activity": [ { "ec_number": "6.3.4.3", "activity": "(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate.", "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ] }, { "ec_number": "6.3.4.3", "activity": "", "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" } ] } ] }, { "uniprot_ac": "Q0VCR7", "gene_name": "MTHFD1L", "activity": [ { "ec_number": "6.3.4.3", "activity": "(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate.", "evidence": [ { "id": "Q0VCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR7" } ] }, { "ec_number": "6.3.4.3", "activity": "", "evidence": [ { "id": "Q0VCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" }, { "id": "PF02882", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02882" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding", "eco_id": "ECO_0000259", "start_pos": 202, "end_pos": 293, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZL73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL73" }, { "id": "PF00763", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00763" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 178, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.4.3", "ec_name": "(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate.", "evidence": [ { "id": "6.3.4.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3" }, { "id": "6.3.4.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 421 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 289, "end_pos": 291 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 687, "end_pos": 689 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZDD2-1", "uniprot_ac": "A0AAF6ZDD2", "uniprot_id": "A0AAF6ZDD2_BOVIN", "mass": { "chemical_mass": 56781.0, "monoisotopic_mass": 56781.0 }, "refseq": {}, "gene_names": [ { "name": "CYP2D14", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2" } ] } ], "protein_names": [ { "name": "Cytochrome P450", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2/entry#names_and_taxonomy" } ] }, { "name": "1.14.14.-", "type": "synonym", "evidence": [ { "id": "A0AAF6ZDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV0#function" }, { "database": "UniProtKB", "id": "RU368047", "url": "https://www.uniprot.org/uniprotkb/RU368047#function" }, { "database": "UniProtKB", "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYP2D14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZDD2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZDD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20663", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20663", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282211", "url": "https://www.ncbi.nlm.nih.gov/gene/282211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TCV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLLSGDTLGPLAVALLIFLLLLDLMHRRSRWAPRYPPGPTPLPVLGNLLQVDFEDPRPSFNQLRRRFGNVFSLQQVWTPVVVLNGLAAVREALVYRSQDTADRPPPAVYEHLGYGPRAEGKRREQVILARYGDAWREQRRFSLTTLRNFGLGKKSLEQWVTEEASCLCAAFADQAGRPFSPMDLLNKAVSNVIASLTFGCRFEYNDPRIIKLLDLTEDGLKEEFNLVRKVVEAVPVLLSIPGLAARVFPAQKAFMALIDELIAEQKMTRDPTQPPRHLTDAFLDEVKEAKGNPESSFNDENLRLVVADLFSAGMVTTSTTLAWALLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQALMPFTVAVVHEVQRFADIVPLGLPHMTSRDIEVQGFHIPKGTTLITNLSSVLKDETVWEKPFRFHPEHFLDAQGRFVKQEAFIPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPAGQPRPSEHGVFAFLVTPAPYQLCAVPR", "length": 505, "header": "tr|A0AAF6ZDD2-1|A0AAF6ZDD2_BOVIN Isoform 1 of Cytochrome P450 OS=Bos taurus OX=9913 GN=CYP2D14 PE=3 SV=1 CANONICAL=A0AAF6ZDD2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV0/entry", "sequence": { "sequence": "MGLLSGDTLGPLAVALLIFLLLLDLMHRRSRWAPRYPPGPTPLPVLGNLLQVDFEDPRPSFNQLRRRFGNVFSLQQVWTPVVVLNGLAAVREALVYRSQDTADRPPPAVYEHLGYGPRAEGVILARYGDAWREQRRFSLTTLRNFGLGKKSLEQWVTEEASCLCAAFADQAGRPFSPMDLLNKAVSNVIASLTFGCRFEYNDPRIIKLLDLTEDGLKEEFNLVRKVVEAVPVLLSIPGLAARVFPAQKAFMALIDELIAEQKMTRDPTQPPRHLTDAFLDEVKEAKGNPESSFNDENLRLVVADLFSAGMVTTSTTLAWALLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQALMPFTVAVVHEVQRFADIVPLGLPHMTSRDIEVQGFHIPKGTTLITNLSSVLKDETVWEKPFRFHPEHFLDAQGRFVKQEAFIPFSAASRRFASDGGRVLSSCADSDAVIFLPWSPGQGQGSPSSTSSPQSGLD", "length": 488, "header": "tr|A0AAA9TCV0-1|A0AAF6ZDD2_BOVIN Computationally mapped isoform of Cytochrome P450 OS=Bos taurus OX=9913 GN=CYP2D14 PE=3 SV=1 CANONICAL=A0AAF6ZDD2-1" }, "locus": { "chromosome": "5", "start_pos": 113094680, "end_pos": 113089463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110093.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110093.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096490.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096490.1" } ] } }, { "isoform_ac": "A0AAF6ZDD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2/entry", "sequence": { "sequence": "MGLLSGDTLGPLAVALLIFLLLLDLMHRRSRWAPRYPPGPTPLPVLGNLLQVDFEDPRPSFNQLRRRFGNVFSLQQVWTPVVVLNGLAAVREALVYRSQDTADRPPPAVYEHLGYGPRAEGKRREQVILARYGDAWREQRRFSLTTLRNFGLGKKSLEQWVTEEASCLCAAFADQAGRPFSPMDLLNKAVSNVIASLTFGCRFEYNDPRIIKLLDLTEDGLKEEFNLVRKVVEAVPVLLSIPGLAARVFPAQKAFMALIDELIAEQKMTRDPTQPPRHLTDAFLDEVKEAKGNPESSFNDENLRLVVADLFSAGMVTTSTTLAWALLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQALMPFTVAVVHEVQRFADIVPLGLPHMTSRDIEVQGFHIPKGTTLITNLSSVLKDETVWEKPFRFHPEHFLDAQGRFVKQEAFIPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPAGQPRPSEHGVFAFLVTPAPYQLCAVPR", "length": 505, "header": "tr|A0AAF6ZDD2-1|A0AAF6ZDD2_BOVIN Isoform 1 of Cytochrome P450 OS=Bos taurus OX=9913 GN=CYP2D14 PE=3 SV=1 CANONICAL=A0AAF6ZDD2-1" }, "locus": { "chromosome": "5", "start_pos": 113094680, "end_pos": 113090540, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037679.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037679.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037503.6", "url": "https://www.ensembl.org/id/ENSBTAP00000037503.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 406, "end_pos": 408 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z5H6-1", "uniprot_ac": "A0AAF6Z5H6", "uniprot_id": "A0AAF6Z5H6_BOVIN", "mass": { "chemical_mass": 10729.0, "monoisotopic_mass": 10729.0 }, "refseq": {}, "gene_names": [ { "name": "RPLP1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein P1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6/entry#names_and_taxonomy" } ] }, { "name": "60S acidic ribosomal protein P1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z5H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays an important role in the elongation step of protein synthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TSG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSG7#function" }, { "database": "UniProtKB", "id": "ARBA00003362", "url": "https://www.uniprot.org/uniprotkb/ARBA00003362#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPLP1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6", "locus": { "chromosome": "10", "start_pos": 16345977, "end_pos": 16343958, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018320", "url": "https://www.ensembl.org/id/ENSBTAG00000018320" } ] } } ], "crossref": [ { "id": "A0AAF6Z5H6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z5H6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05831", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05831", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45696", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45696", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45696:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45696:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00428", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00428", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TSG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPCASSLGHRPCARPREDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD", "length": 107, "header": "tr|A0AAF6Z5H6-1|A0AAF6Z5H6_BOVIN Isoform 1 of Large ribosomal subunit protein P1 OS=Bos taurus OX=9913 GN=RPLP1 PE=3 SV=1 CANONICAL=A0AAF6Z5H6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TSG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSG7/entry", "sequence": { "sequence": "MASVSELACIYSALILHDDEVTVTALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD", "length": 89, "header": "tr|A0AAA9TSG7-1|A0AAF6Z5H6_BOVIN Computationally mapped isoform of Large ribosomal subunit protein P1 OS=Bos taurus OX=9913 GN=RPLP1 PE=3 SV=1 CANONICAL=A0AAF6Z5H6-1" }, "locus": { "chromosome": "10", "start_pos": 16345935, "end_pos": 16343958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117387.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117387.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101324.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101324.1" } ] } }, { "isoform_ac": "A0AAF6Z5H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6/entry", "sequence": { "sequence": "MGPCASSLGHRPCARPREDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD", "length": 107, "header": "tr|A0AAF6Z5H6-1|A0AAF6Z5H6_BOVIN Isoform 1 of Large ribosomal subunit protein P1 OS=Bos taurus OX=9913 GN=RPLP1 PE=3 SV=1 CANONICAL=A0AAF6Z5H6-1" }, "locus": { "chromosome": "10", "start_pos": 16345935, "end_pos": 16344179, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024376.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024376.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024376.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024376.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translational elongation", "id": "GO:0006414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006414", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5H6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5H6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZFU3-1", "uniprot_ac": "A0AAF6ZFU3", "uniprot_id": "A0AAF6ZFU3_BOVIN", "mass": { "chemical_mass": 15721.0, "monoisotopic_mass": 15721.0 }, "refseq": { "ac": "XP_024851748", "name": "bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851748" }, "gene_names": [ { "name": "NUDT2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ] }, { "name": "NUDT2", "type": "synonym", "evidence": [ { "id": "XP_024851748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851748" } ] } ], "protein_names": [ { "name": "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.17", "type": "synonym", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3/entry#names_and_taxonomy" } ] }, { "name": "Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3/entry#names_and_taxonomy" } ] }, { "name": "Nucleoside diphosphate-linked moiety X motif 2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3/entry#names_and_taxonomy" } ] }, { "name": "bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024851748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851748" } ] } ], "function": [ { "annotation": "Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFU3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3#function" }, { "database": "UniProtKB", "id": "ARBA00045172", "url": "https://www.uniprot.org/uniprotkb/ARBA00045172#function" }, { "database": "UniProtKB", "id": "A0AAA9TWM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFU3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3", "locus": { "chromosome": "8", "start_pos": 75735974, "end_pos": 75724298, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031793", "url": "https://www.ensembl.org/id/ENSBTAG00000031793" } ] } } ], "crossref": [ { "id": "A0AAF6ZFU3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZFU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03428", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03428", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768044", "url": "https://www.ncbi.nlm.nih.gov/gene/768044", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21340:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21340:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00293", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00293", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851748", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851748", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22484", "url": "https://www.rhea-db.org/rhea/22484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67588", "url": "https://www.rhea-db.org/rhea/67588", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67592", "url": "https://www.rhea-db.org/rhea/67592", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TWM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFU3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRACGLIIFRRRLIPKVDNTAIEFLLLQASDGHVEPGESDLETALRETQEEAGIEAGQLTIIEGFRRELSYVARAKPKIVIYWLAEVKDCDVEVRLSREHQAYRWLELEDACQLAQFEEMKAALQEGHQFLCSTAT", "length": 138, "header": "tr|A0AAF6ZFU3-1|A0AAF6ZFU3_BOVIN Isoform 1 of Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Bos taurus OX=9913 GN=NUDT2 PE=3 SV=1 CANONICAL=A0AAF6ZFU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TWM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM6/entry", "sequence": { "sequence": "MKRAPEKNRAEVWGRPTSTSRSSILDQTCQIYGHVEPGESDLETALRETQEEAGIEAGQLTIIEGFRRELSYVARAKPKIVIYWLAEVKDCDVEVRLSREHQAYRWLELEDACQLAQFEEMKAALQEGHQFLCSTAT", "length": 137, "header": "tr|A0AAA9TWM6-1|A0AAF6ZFU3_BOVIN Computationally mapped isoform of Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Bos taurus OX=9913 GN=NUDT2 PE=3 SV=1 CANONICAL=A0AAF6ZFU3-1" }, "locus": { "chromosome": "8", "start_pos": 75734970, "end_pos": 75734333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101862.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101862.1" } ] } }, { "isoform_ac": "A0AAF6ZFU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3/entry", "sequence": { "sequence": "MALRACGLIIFRRRLIPKVDNTAIEFLLLQASDGHVEPGESDLETALRETQEEAGIEAGQLTIIEGFRRELSYVARAKPKIVIYWLAEVKDCDVEVRLSREHQAYRWLELEDACQLAQFEEMKAALQEGHQFLCSTAT", "length": 138, "header": "tr|A0AAF6ZFU3-1|A0AAF6ZFU3_BOVIN Isoform 1 of Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Bos taurus OX=9913 GN=NUDT2 PE=3 SV=1 CANONICAL=A0AAF6ZFU3-1" }, "locus": { "chromosome": "8", "start_pos": 75734970, "end_pos": 75732418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045076.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045076.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042493.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042493.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFU3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ], "pmid": "" }, { "name": "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "id": "GO:0004081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004081", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFU3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22484", "name": "", "equation": "P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15396-1", "A0AAF6ZFU3-1", "Q29RJ1-1" ], "evidence": [ { "id": "22484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22484" } ] }, { "id": "67588", "name": "", "equation": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZFU3-1", "A1A4Q9-1", "Q29RJ1-1" ], "evidence": [ { "id": "67588", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67588" } ] }, { "id": "67592", "name": "", "equation": "a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZFU3-1", "A0A3Q1M899-1", "A1A4Q9-1", "Q29RJ1-1", "A0AAA9T520-1" ], "evidence": [ { "id": "67592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67592" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M899", "gene_name": "NUDT19", "activity": [ { "ec_number": "3.6.1.77", "activity": "CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1M899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M899" } ] }, { "ec_number": "3.6.1.77", "activity": "", "evidence": [ { "id": "A0A3Q1M899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M899" } ] } ] }, { "uniprot_ac": "A0AAA9T520", "gene_name": "NUDT15", "activity": [ { "ec_number": "3.6.1.9", "activity": "dTTP + H2O = dTMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.68", "activity": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.76", "activity": "dimethylallyl diphosphate + H2O = dimethylallyl phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.76", "activity": "", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.9", "activity": "", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.68", "activity": "", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] } ] }, { "uniprot_ac": "A0AAF6ZFU3", "gene_name": "NUDT2", "activity": [ { "ec_number": "3.6.1.17", "activity": "P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+).", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ] }, { "ec_number": "3.6.1.17", "activity": "", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ] } ] }, { "uniprot_ac": "A1A4Q9", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] } ] }, { "uniprot_ac": "P15396", "gene_name": "ENPP3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.6.1.9", "activity": "dTTP + H2O = dTMP + diphosphate + H(+).", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.1.4.1", "activity": "", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.6.1.9", "activity": "", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] } ] }, { "uniprot_ac": "Q29RJ1", "gene_name": "NUDT2", "activity": [ { "ec_number": "3.6.1.17", "activity": "P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+).", "evidence": [ { "id": "Q29RJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RJ1" } ] }, { "ec_number": "3.6.1.17", "activity": "", "evidence": [ { "id": "Q29RJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RJ1" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 130, "start_aa": "Met", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.17", "ec_name": "P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+).", "evidence": [ { "id": "3.6.1.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.17" }, { "id": "3.6.1.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.17" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCM4-1", "uniprot_ac": "A0AAF6ZCM4", "uniprot_id": "A0AAF6ZCM4_BOVIN", "mass": { "chemical_mass": 53072.0, "monoisotopic_mass": 53072.0 }, "refseq": {}, "gene_names": [ { "name": "SF3A2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ] } ], "protein_names": [ { "name": "Splicing factor 3a subunit 2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A2K4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A2K4#function" }, { "database": "UniProtKB", "id": "ARBA00055377", "url": "https://www.uniprot.org/uniprotkb/ARBA00055377#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SF3A2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4", "locus": { "chromosome": "7", "start_pos": 21404348, "end_pos": 21396452, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025452", "url": "https://www.ensembl.org/id/ENSBTAG00000025452" } ] } } ], "crossref": [ { "id": "A0AAF6ZCM4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23205:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23205:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16835", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16835", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A2K4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A2K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A2K4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A2K4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDTEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVVRWDPGGSCRVCSIQAAGPGPHQVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPSGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPVVHPPAPAVHPQAPGVHPTPAVHPQAPGVHPPAPGVHPPAPGIHPQPPGVHPPPPGVHPPAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN", "length": 501, "header": "tr|A0AAF6ZCM4-1|A0AAF6ZCM4_BOVIN Isoform 1 of Splicing factor 3a subunit 2 OS=Bos taurus OX=9913 GN=SF3A2 PE=3 SV=2 CANONICAL=A0AAF6ZCM4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZCM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4/entry", "sequence": { "sequence": "MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDTEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVVRWDPGGSCRVCSIQAAGPGPHQVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPSGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPVVHPPAPAVHPQAPGVHPTPAVHPQAPGVHPPAPGVHPPAPGIHPQPPGVHPPPPGVHPPAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN", "length": 501, "header": "tr|A0AAF6ZCM4-1|A0AAF6ZCM4_BOVIN Isoform 1 of Splicing factor 3a subunit 2 OS=Bos taurus OX=9913 GN=SF3A2 PE=3 SV=2 CANONICAL=A0AAF6ZCM4-1" }, "locus": { "chromosome": "7", "start_pos": 21400679, "end_pos": 21396491, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035788.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035788.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035656.7", "url": "https://www.ensembl.org/id/ENSBTAP00000035656.7" } ] } }, { "isoform_ac": "A0AAF7A2K4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A2K4/entry", "sequence": { "sequence": "MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDTEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPLPPMPPSGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPVVHPPAPAVHPQAPGVHPTPAVHPQAPGVHPPAPGVHPPAPGIHPQPPGVHPPPPGVHPPAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN", "length": 459, "header": "tr|A0AAF7A2K4-1|A0AAF7A2K4_BOVIN Computationally mapped isoform of Splicing factor 3A subunit 2 OS=Bos taurus OX=9913 GN=SF3A2 PE=3 SV=1 CANONICAL=A0AAF6ZCM4-1" }, "locus": { "chromosome": "7", "start_pos": 21400679, "end_pos": 21396491, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067195.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067195.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062091.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062091.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 413, "start_aa": "Thr", "end_pos": 413, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr413", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "U2-type prespliceosome assembly", "id": "GO:1903241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903241", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "U2 snRNP", "id": "GO:0005686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005686", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCM4" }, { "id": "PS50171", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Matrin-type", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 84, "start_aa": "Tyr", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 413 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0B1-1", "uniprot_ac": "A0AAF6Z0B1", "uniprot_id": "A0AAF6Z0B1_BOVIN", "mass": { "chemical_mass": 33978.0, "monoisotopic_mass": 33978.0 }, "refseq": { "ac": "XP_015329083", "name": "beta-lactoglobulin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329083" }, "gene_names": [ { "name": "PAEP", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1" } ] }, { "name": "BLG", "type": "synonym", "evidence": [ { "id": "XP_015329083", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329083" } ] }, { "name": "LGB", "type": "synonym", "evidence": [ { "id": "XP_015329083", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329083" } ] }, { "name": "PAEP", "type": "synonym", "evidence": [ { "id": "XP_015329083", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329083" } ] } ], "protein_names": [ { "name": "Beta-lactoglobulin", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1/entry#names_and_taxonomy" } ] }, { "name": "beta-lactoglobulin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015329083", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329083" } ] } ], "function": [ { "annotation": "Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1#function" }, { "database": "UniProtKB", "id": "ARBA00054624", "url": "https://www.uniprot.org/uniprotkb/ARBA00054624#function" }, { "database": "UniProtKB", "id": "A0A3Q1M701", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M701#function" }, { "database": "UniProtKB", "id": "A0ABI0NXB9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXB9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAEP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z0B1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0B1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014678", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014678", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "280838", "url": "https://www.ncbi.nlm.nih.gov/gene/280838", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LYE8", "url": "https://www.orthodb.org/?gene=A0A3Q1LYE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M701", "url": "https://www.orthodb.org/?gene=A0A3Q1M701", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430:SF117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430:SF117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015329083", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329083", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M701", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M701", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M701-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M701-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0B1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXB9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXB9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPKAEATLQDTPAPSAGSDLSLSKRLTPEVFLALAASLDPEPGHPLRPHFWGVPGTVQAQRGPSCLASNGRRPPIVLVEEATPGPKDRPGGIRGTAWLGARPGLAGWPSSCIRPRAHCLSPPLPAELRSVTPAAAMKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI", "length": 314, "header": "tr|A0AAF6Z0B1-1|A0AAF6Z0B1_BOVIN Isoform 1 of Beta-lactoglobulin OS=Bos taurus OX=9913 GN=PAEP PE=3 SV=1 CANONICAL=A0AAF6Z0B1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYE8/entry", "sequence": { "sequence": "MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWWNGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEATHTWSPQLTPKTRSRSPCHLDPRRGHRARLALDMSVFPVALGASQGTGQRSEPEGQVVQSRRPNFKTSKAL", "length": 245, "header": "tr|A0A3Q1LYE8-1|A0AAF6Z0B1_BOVIN Computationally mapped isoform of Beta-lactoglobulin OS=Bos taurus OX=9913 GN=PAEP PE=3 SV=1 CANONICAL=A0AAF6Z0B1-1" }, "locus": { "chromosome": "11", "start_pos": 103264273, "end_pos": 103256179, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069549.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069549.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062602.1" } ] } }, { "isoform_ac": "A0A3Q1M701-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M701/entry", "sequence": { "sequence": "MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEPGSLGPSGDRRCHPRLPHQGTRRNRDHIHPSWDPGPSRPLLGPPAWGRSSFSNKGINLCSPF", "length": 236, "header": "tr|A0A3Q1M701-1|A0AAF6Z0B1_BOVIN Computationally mapped isoform of Beta-lactoglobulin OS=Bos taurus OX=9913 GN=PAEP PE=3 SV=3 CANONICAL=A0AAF6Z0B1-1" }, "locus": { "chromosome": "11", "start_pos": 103260867, "end_pos": 103256179, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081923.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081923.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065811.3", "url": "https://www.ensembl.org/id/ENSBTAP00000065811.3" } ] } }, { "isoform_ac": "A0AAF6Z0B1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1/entry", "sequence": { "sequence": "MVPKAEATLQDTPAPSAGSDLSLSKRLTPEVFLALAASLDPEPGHPLRPHFWGVPGTVQAQRGPSCLASNGRRPPIVLVEEATPGPKDRPGGIRGTAWLGARPGLAGWPSSCIRPRAHCLSPPLPAELRSVTPAAAMKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI", "length": 314, "header": "tr|A0AAF6Z0B1-1|A0AAF6Z0B1_BOVIN Isoform 1 of Beta-lactoglobulin OS=Bos taurus OX=9913 GN=PAEP PE=3 SV=1 CANONICAL=A0AAF6Z0B1-1" }, "locus": { "chromosome": "11", "start_pos": 103260262, "end_pos": 103255771, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019538.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019538.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019538.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019538.7" } ] } }, { "isoform_ac": "A0ABI0NXB9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXB9/entry", "sequence": { "sequence": "MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVEELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEGEHPGPTLLLGQEATRPRTTSSHGDPQLPRPPGRMETGCRAPRWPPPHPLPSSLCPGVSSPILTLPRHGSPSPTEQCHI", "length": 252, "header": "tr|A0ABI0NXB9-1|A0ABI0NXB9_BOVIN Computationally mapped isoform of Beta-lactoglobulin OS=Bos taurus OX=9913 GN=PAEP PE=3 SV=1 CANONICAL=A0AAF6Z0B1-1" }, "locus": { "chromosome": "11", "start_pos": 103260262, "end_pos": 103256179, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149288.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149288.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105846.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105846.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 83, "start_aa": "Thr", "end_pos": 83, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr83", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "retinol binding", "id": "GO:0019841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019841", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z0B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0B1" }, { "id": "PF00061", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipocalin/cytosolic fatty-acid binding", "eco_id": "ECO_0000259", "start_pos": 168, "end_pos": 303, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 83 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZHK6-1", "uniprot_ac": "A0AAF6ZHK6", "uniprot_id": "A0AAF6ZHK6_BOVIN", "mass": { "chemical_mass": 35516.0, "monoisotopic_mass": 35516.0 }, "refseq": {}, "gene_names": [ { "name": "C4H7orf57", "type": "recommended", "evidence": [ { "id": "A0AAF6ZHK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6" } ] } ], "protein_names": [ { "name": "Chromosome 4 C7orf57 homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6ZHK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C4H7orf57", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZHK6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZHK6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR040247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM93", "url": "https://www.orthodb.org/?gene=A0A3Q1MM93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31097:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31097:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MM93", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM93-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNTSKELHGAASRYAPCDWYYHLPVKQSEKAVDAPPASQIPGLSDPREAPSGHTLGLRRYWVKETDSEYVKLAKQGGRPGECFCVCGGRWAKQGGRPGECFCVCGGRWAKQGGRPDLLKHFAPGTTKGSPVAYSLPDWYIHHSKPPTADQRQVPAVSIPDYMVYEEFNPDQATGNFESRMGPFDFDMKTIWQREAEELEKEKKKVRLPAIKSKYPSKVGTPLGHREPAGSKLSFPPIPGQRPSSPTNFSKLISNGYKDEWLQQQADSDKRAPQTPQSSVSSPSPLDAELPADPEAPGDTTEAAESSPLSSAAPPPDSTPVELK", "length": 324, "header": "tr|A0AAF6ZHK6-1|A0AAF6ZHK6_BOVIN Isoform 1 of Chromosome 4 C7orf57 homolog OS=Bos taurus OX=9913 GN=C4H7orf57 PE=4 SV=1 CANONICAL=A0AAF6ZHK6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MM93-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM93/entry", "sequence": { "sequence": "MRNTSKELHGAASRYAPCDWYYHLPVKQSEKAVDAPPASQIPGLSDPREAPSGHTLGLRRYWVKETDSEYVKLAKQGGRPDLLKHFAPGTTKGSPVAYSLPDWYIHHSKPPTADQRQVPAVSIPDYMVYEEFNPDQATGNFESRMGPFDFDMKTIWQREAEELEKEKKKVRLPAIKSKYPSKVGTPLGHREPAGSKLSFPPIPGQRPSSPTNFSKLISNGYKDEWLQQQADSDKRAPQTPQSSVSSPSPLDAELPADPEAPGDTTEAAESSPLSMGKHTLPGS", "length": 283, "header": "tr|A0A3Q1MM93-1|A0AAF6ZHK6_BOVIN Computationally mapped isoform of Chromosome 4 C7orf57 homolog OS=Bos taurus OX=9913 GN=C4H7orf57 PE=4 SV=2 CANONICAL=A0AAF6ZHK6-1" }, "locus": { "chromosome": "4", "start_pos": 7696892, "end_pos": 7667578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074187.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074187.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072897.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072897.2" } ] } }, { "isoform_ac": "A0AAF6ZHK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHK6/entry", "sequence": { "sequence": "MRNTSKELHGAASRYAPCDWYYHLPVKQSEKAVDAPPASQIPGLSDPREAPSGHTLGLRRYWVKETDSEYVKLAKQGGRPGECFCVCGGRWAKQGGRPGECFCVCGGRWAKQGGRPDLLKHFAPGTTKGSPVAYSLPDWYIHHSKPPTADQRQVPAVSIPDYMVYEEFNPDQATGNFESRMGPFDFDMKTIWQREAEELEKEKKKVRLPAIKSKYPSKVGTPLGHREPAGSKLSFPPIPGQRPSSPTNFSKLISNGYKDEWLQQQADSDKRAPQTPQSSVSSPSPLDAELPADPEAPGDTTEAAESSPLSSAAPPPDSTPVELK", "length": 324, "header": "tr|A0AAF6ZHK6-1|A0AAF6ZHK6_BOVIN Isoform 1 of Chromosome 4 C7orf57 homolog OS=Bos taurus OX=9913 GN=C4H7orf57 PE=4 SV=1 CANONICAL=A0AAF6ZHK6-1" }, "locus": { "chromosome": "4", "start_pos": 7696892, "end_pos": 7669239, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049538.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049538.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046417.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046417.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 248, "end_pos": 250 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZDE8-1", "uniprot_ac": "A0AAF6ZDE8", "uniprot_id": "A0AAF6ZDE8_BOVIN", "mass": { "chemical_mass": 47567.0, "monoisotopic_mass": 47567.0 }, "refseq": { "ac": "XP_059748551", "name": "sorting nexin-5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748551" }, "gene_names": [ { "name": "SNX5", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ] }, { "name": "SNX5", "type": "synonym", "evidence": [ { "id": "XP_059748551", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748551" } ] } ], "protein_names": [ { "name": "Sorting nexin", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8/entry#names_and_taxonomy" } ] }, { "name": "sorting nexin-5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059748551", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748551" } ] } ], "function": [ { "annotation": "Involved in several stages of intracellular trafficking.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8#function" }, { "database": "UniProtKB", "id": "PIRNR036924", "url": "https://www.uniprot.org/uniprotkb/PIRNR036924#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8", "locus": { "chromosome": "13", "start_pos": 38215110, "end_pos": 38239985, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003422", "url": "https://www.ensembl.org/id/ENSBTAG00000003422" } ] } } ], "crossref": [ { "id": "A0AAF6ZDE8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZDE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003422", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003422", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07291", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07291", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07663", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07663", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514423", "url": "https://www.ncbi.nlm.nih.gov/gene/514423", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MR47", "url": "https://www.orthodb.org/?gene=A0A3Q1MR47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45850:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45850:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09325", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09325", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059748551", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059748551", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR47", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR47-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5I4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5I4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5I4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVPEVLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKTFLINYYNRIKDSCAKADRMTRSHKNVADDYIHTAACLHSLALEEPTVIKKIVYICRYLLKVAELFEKLRKVESRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSRDVKLAEAHQQECCQKFEQLSESAKDELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN", "length": 410, "header": "tr|A0AAF6ZDE8-1|A0AAF6ZDE8_BOVIN Isoform 1 of Sorting nexin OS=Bos taurus OX=9913 GN=SNX5 PE=3 SV=1 CANONICAL=A0AAF6ZDE8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MR47-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR47/entry", "sequence": { "sequence": "MHLRAVVPTVLKNVFQLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKTFLINYYNRIKDSCAKADRMTRSHKSECTHPLAPYLCLSVAELFEKLRKVESRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSRDVKLAEAHQQECCQKFEQLSESAKDELINFKRKRVAAFRKNLIEMSELEIKHARVSLIFTRVSFGGCFSN", "length": 387, "header": "tr|A0A3Q1MR47-1|A0AAF6ZDE8_BOVIN Computationally mapped isoform of Sorting nexin OS=Bos taurus OX=9913 GN=SNX5 PE=3 SV=2 CANONICAL=A0AAF6ZDE8-1" }, "locus": { "chromosome": "13", "start_pos": 38229535, "end_pos": 38216945, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079751.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079751.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074167.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074167.2" } ] } }, { "isoform_ac": "A0AAA9S5I4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5I4/entry", "sequence": { "sequence": "MAAVPEVLQQQEEDRSKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKTFLINYYNRIKDSCAKADRMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVESRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSRDVKLAEAHQQECCQKFEQLSESAKDELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN", "length": 369, "header": "tr|A0AAA9S5I4-1|A0AAF6ZDE8_BOVIN Computationally mapped isoform of Sorting nexin OS=Bos taurus OX=9913 GN=SNX5 PE=3 SV=1 CANONICAL=A0AAF6ZDE8-1" }, "locus": { "chromosome": "13", "start_pos": 38239786, "end_pos": 38215788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109001.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109001.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078512.1" } ] } }, { "isoform_ac": "A0AAF6ZDE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8/entry", "sequence": { "sequence": "MAAVPEVLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSGVKEVDDFFEQEKTFLINYYNRIKDSCAKADRMTRSHKNVADDYIHTAACLHSLALEEPTVIKKIVYICRYLLKVAELFEKLRKVESRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSRDVKLAEAHQQECCQKFEQLSESAKDELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN", "length": 410, "header": "tr|A0AAF6ZDE8-1|A0AAF6ZDE8_BOVIN Isoform 1 of Sorting nexin OS=Bos taurus OX=9913 GN=SNX5 PE=3 SV=1 CANONICAL=A0AAF6ZDE8-1" }, "locus": { "chromosome": "13", "start_pos": 38239786, "end_pos": 38215788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039411.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039411.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039205.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039205.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ], "pmid": "" }, { "name": "pinocytosis", "id": "GO:0006907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006907", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZDE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDE8" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 172, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 396, "end_pos": 398 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZIH9-1", "uniprot_ac": "A0AAF6ZIH9", "uniprot_id": "A0AAF6ZIH9_BOVIN", "mass": { "chemical_mass": 30817.0, "monoisotopic_mass": 30817.0 }, "refseq": {}, "gene_names": [ { "name": "TATDN3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ] } ], "protein_names": [ { "name": "TatD DNase domain containing 3", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TATDN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9", "locus": { "chromosome": "16", "start_pos": 70756420, "end_pos": 70771015, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024443", "url": "https://www.ensembl.org/id/ENSBTAG00000024443" } ] } } ], "crossref": [ { "id": "A0AAF6ZIH9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZIH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01310", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01310", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615965", "url": "https://www.ncbi.nlm.nih.gov/gene/615965", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46317:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46317:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RS41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RS41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U185", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U185", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U185-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U185-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAVGVGLVDCHCHLSAPDFDHDLDDVLKKAKEANVMALVVVAEHSGEFEKIMQLSQRYNGFVLPCLGVHPVQGVSPEDQRSVTLKDLDVALPIIENYKDQLLAIGEVGLDFSPRFAGTDEQKEEQRQVLIRQVQLAKRLNLPLNVHSRSAGRPTISLLNEQGADKVLLHAFDGRPSVAMEGVKAGYFFSIPPSIIRSGQLSLFSKKQKLVKQLPLTSICLETDSPALGPEKQVRNEPRNISISAEYIAQVKGVSVEEVIEVTTQNALKLFPKLQRLLPK", "length": 280, "header": "tr|A0AAF6ZIH9-1|A0AAF6ZIH9_BOVIN Isoform 1 of TatD DNase domain containing 3 OS=Bos taurus OX=9913 GN=TATDN3 PE=3 SV=1 CANONICAL=A0AAF6ZIH9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RS41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS41/entry", "sequence": { "sequence": "MGAVGVGLVDCHCHLSAPDFDHDLDDVLKKAKEANVMALVVVAEHSGEFEKIMQLSQRIWM", "length": 61, "header": "tr|A0AAA9RS41-1|A0AAF6ZIH9_BOVIN Computationally mapped isoform of TatD DNase domain containing 3 OS=Bos taurus OX=9913 GN=TATDN3 PE=3 SV=1 CANONICAL=A0AAF6ZIH9-1" }, "locus": { "chromosome": "16", "start_pos": 70770895, "end_pos": 70765388, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132877.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132877.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075204.1" } ] } }, { "isoform_ac": "A0AAA9RW36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW36/entry", "sequence": { "sequence": "MGAVGVGLVDCHCHLSAPDFDHANVMALVVVAEHSGEFEKIMQLSQRYNGFVLPCLGVHPVQGVSPEDQRSVTLKDLDVALPIIENYKDQLLAIGEVGLDFSPRFAGTDEQKEEQRQVLIRQVQLAKRLNLPLNVHSRSAGRPTISLLNEQGADKVLLHAFDGRPSVAMEGVKAGYFFSIPPSIIRSGQQKLVKQLPLTSICLETDSPALGPEKQVRNEPRNISISAEYIAQVKGVSVEEVIEVTTQNALKLFPKLQRLLPK", "length": 262, "header": "tr|A0AAA9RW36-1|A0AAF6ZIH9_BOVIN Computationally mapped isoform of TatD DNase domain containing 3 OS=Bos taurus OX=9913 GN=TATDN3 PE=3 SV=1 CANONICAL=A0AAF6ZIH9-1" }, "locus": { "chromosome": "16", "start_pos": 70770895, "end_pos": 70757018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124991.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124991.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075255.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075255.1" } ] } }, { "isoform_ac": "A0AAA9SWI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWI9/entry", "sequence": { "sequence": "MGAVGVGLVDCHCHLSAPDFDHDLDDVLKKAKEANVMALVVVAEHSGEFEKIMQLSQRYNGFVLPCLGVHPVQGVSPEDQRSVTLKVGLDFSPRFAGTDEQKEEQRQVLIRQVQLAKRLNLPLNVHSRSAGRPTISLLNEQGADKVLLHAFDGRPSVAMEGVKAGYFFSIPPSIIRSGQKQKLVKQLPLTSICLETDSPALGPEKQVRNEPRNISISAEYIAQVKGVSVEEVIEVTTQNALKLFPKLQRLLPK", "length": 253, "header": "tr|A0AAA9SWI9-1|A0AAF6ZIH9_BOVIN Computationally mapped isoform of TatD DNase domain containing 3 OS=Bos taurus OX=9913 GN=TATDN3 PE=3 SV=1 CANONICAL=A0AAF6ZIH9-1" }, "locus": { "chromosome": "16", "start_pos": 70770895, "end_pos": 70757018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091026.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091026.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088591.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088591.1" } ] } }, { "isoform_ac": "A0AAA9U185-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U185/entry", "sequence": { "sequence": "MGAVGVGLVDCHCHLSAPDFDHDLDDVLKKAKEANVMALVVVAEHSGEFEKIMQLSQRYNGFVLPCLGVHPVQGVSPEDQRSVTLKDLDVALPIIENYKDQLLAIGEVGLDFSPRFAGTDEQKEEQRQVLIRQVQLAKRLNLPLNVHSRSAGRPTISLLNEQAETCETVAFNFNLFRNGFPCTGTRKTGTE", "length": 191, "header": "tr|A0AAA9U185-1|A0AAF6ZIH9_BOVIN Computationally mapped isoform of TatD DNase domain containing 3 OS=Bos taurus OX=9913 GN=TATDN3 PE=3 SV=1 CANONICAL=A0AAF6ZIH9-1" }, "locus": { "chromosome": "16", "start_pos": 70770895, "end_pos": 70757151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115214.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115214.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103802.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103802.1" } ] } }, { "isoform_ac": "A0AAF6ZIH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9/entry", "sequence": { "sequence": "MGAVGVGLVDCHCHLSAPDFDHDLDDVLKKAKEANVMALVVVAEHSGEFEKIMQLSQRYNGFVLPCLGVHPVQGVSPEDQRSVTLKDLDVALPIIENYKDQLLAIGEVGLDFSPRFAGTDEQKEEQRQVLIRQVQLAKRLNLPLNVHSRSAGRPTISLLNEQGADKVLLHAFDGRPSVAMEGVKAGYFFSIPPSIIRSGQLSLFSKKQKLVKQLPLTSICLETDSPALGPEKQVRNEPRNISISAEYIAQVKGVSVEEVIEVTTQNALKLFPKLQRLLPK", "length": 280, "header": "tr|A0AAF6ZIH9-1|A0AAF6ZIH9_BOVIN Isoform 1 of TatD DNase domain containing 3 OS=Bos taurus OX=9913 GN=TATDN3 PE=3 SV=1 CANONICAL=A0AAF6ZIH9-1" }, "locus": { "chromosome": "16", "start_pos": 70770895, "end_pos": 70757018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052023.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052023.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048497.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048497.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "hydrolase activity, acting on ester bonds", "id": "GO:0016788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016788", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "pmid": "" }, { "name": "single-stranded DNA 3'-5' DNA exonuclease activity", "id": "GO:0008310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008310", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "pmid": "" }, { "name": "DNA-(apurinic or apyrimidinic site) endonuclease activity", "id": "GO:0003906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003906", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" }, { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 107, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 107, "end_pos": 107, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" }, { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "binding_site_uniprot": 12, "amino_acid": "His", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 12, "end_pos": 12, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 126, "amino_acid": "Gln", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 126, "end_pos": 126, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 136, "amino_acid": "Leu", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 136, "end_pos": 136, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" }, { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" } ], "binding_site_uniprot": 14, "amino_acid": "His", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 14, "end_pos": 14, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" }, { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 147, "amino_acid": "His", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 147, "end_pos": 147, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 149, "amino_acid": "Arg", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 149, "end_pos": 149, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 159, "amino_acid": "Leu", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 159, "end_pos": 159, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" }, { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 170, "amino_acid": "His", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 170, "end_pos": 170, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 197, "amino_acid": "Arg", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 197, "end_pos": 197, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 206, "amino_acid": "Lys", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 206, "end_pos": 206, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZIH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIH9" }, { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 224, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 224, "end_pos": 224, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR005902-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005902-1" } ], "binding_site_uniprot": 96, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:60240", "ligand": "divalent metal cation", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 96, "end_pos": 96, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 240, "end_pos": 242 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7P4-1", "uniprot_ac": "A0AAF6Z7P4", "uniprot_id": "A0AAF6Z7P4_BOVIN", "mass": { "chemical_mass": 42735.0, "monoisotopic_mass": 42735.0 }, "refseq": {}, "gene_names": [ { "name": "MYG1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ] } ], "protein_names": [ { "name": "MYG1 exonuclease", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYG1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4", "locus": { "chromosome": "5", "start_pos": 26712725, "end_pos": 26724283, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020177", "url": "https://www.ensembl.org/id/ENSBTAG00000020177" } ] } } ], "crossref": [ { "id": "A0AAF6Z7P4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7P4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11215:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11215:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RV32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGHRFLRGFLRVLLPPLPLRSPHLKLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKMYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPHLPQIPW", "length": 377, "header": "tr|A0AAF6Z7P4-1|A0AAF6Z7P4_BOVIN Isoform 1 of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=3 SV=1 CANONICAL=A0AAF6Z7P4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RV32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV32/entry", "sequence": { "sequence": "KLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPHLPQIPW", "length": 302, "header": "tr|A0AAA9RV32-1|A0AAF6Z7P4_BOVIN Computationally mapped isoform of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=3 SV=1 CANONICAL=A0AAF6Z7P4-1" }, "locus": { "chromosome": "5", "start_pos": 26724192, "end_pos": 26716873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107366.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107366.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077140.1" } ] } }, { "isoform_ac": "A0AAA9SI89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI89/entry", "sequence": { "sequence": "MGHRFLRGFLRVLLPPLPLRSPHLKLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKMYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGDTSSIPGAGRFHRPVHRNC", "length": 369, "header": "tr|A0AAA9SI89-1|A0AAF6Z7P4_BOVIN Computationally mapped isoform of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=3 SV=1 CANONICAL=A0AAF6Z7P4-1" }, "locus": { "chromosome": "5", "start_pos": 26724264, "end_pos": 26712897, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124528.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124528.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085050.1" } ] } }, { "isoform_ac": "A0AAA9SV34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV34/entry", "sequence": { "sequence": "MYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPHLPQIPW", "length": 214, "header": "tr|A0AAA9SV34-1|A0AAF6Z7P4_BOVIN Computationally mapped isoform of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=3 SV=1 CANONICAL=A0AAF6Z7P4-1" }, "locus": { "chromosome": "5", "start_pos": 26717911, "end_pos": 26716873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113763.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113763.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087045.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087045.1" } ] } }, { "isoform_ac": "A0AAF6Z7P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4/entry", "sequence": { "sequence": "MGHRFLRGFLRVLLPPLPLRSPHLKLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKMYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPHLPQIPW", "length": 377, "header": "tr|A0AAF6Z7P4-1|A0AAF6Z7P4_BOVIN Isoform 1 of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=3 SV=1 CANONICAL=A0AAF6Z7P4-1" }, "locus": { "chromosome": "5", "start_pos": 26724264, "end_pos": 26716873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026875.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026875.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026875.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026875.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitochondrial RNA metabolic process", "id": "GO:0000959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000959", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "3'-5'-RNA exonuclease activity", "id": "GO:0000175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000175", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7P4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7P4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z555-1", "uniprot_ac": "A0AAF6Z555", "uniprot_id": "A0AAF6Z555_BOVIN", "mass": { "chemical_mass": 63159.0, "monoisotopic_mass": 63159.0 }, "refseq": {}, "gene_names": [ { "name": "POLG2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ] } ], "protein_names": [ { "name": "DNA polymerase gamma 2, accessory subunit", "type": "synonym", "evidence": [ { "id": "A0AAF6Z555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLG2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555", "locus": { "chromosome": "19", "start_pos": 48634490, "end_pos": 48677027, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018420", "url": "https://www.ensembl.org/id/ENSBTAG00000018420" } ] } } ], "crossref": [ { "id": "A0AAF6Z555", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z555", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02426", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02426", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10745", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10745", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10745:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10745:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RWE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z555-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSAPAIRACQRICRCLLSGFGGQVDGRQPEQLSKGTGSFVGPVRSQAELPRNEPREAPESGGEGSEPLVEICRKRRFLSGTKQQLSRDSLLNGCHPGLGPLGIELRKNLAAEWWSSVVVFREQVFPVDALHREPGPSLPVDNGFRLVSAETLREILQDKELSKEQLVAFLENLLNTSGKLRENLLHGALEHYVSYLDLVNKRLPFGLAQIGACFHPVSDTKQTPDGVKRIGEKTEASLVWFTSARTASQWLDFWLRHRLLWWRKFAMSPSNFSSGDCQDEAGRKGNRLYYNFPWGKEPIETLWNLGDHELLHMYPGSVAQVHGRDGRKNVVPSVLSINGDLDRGMLAYLYDSFQLTENSFTRKKDLHRKVLKLHPCLAPIKAALDVGRGPTVELRQVCQGLFNELLENGISVWPGYLETVQSSLEQLYSKYDEMSILFTVLITEATLENGLIQLRSRDTTMKEMMHISKGPQASQEDCIPGLRSADCTNWQHGISKHQLGIQNARTRMIIISTNNNPGSRSCRQNGPQSPPGRRRRQHSLVTAQPAFPMILNCGMFWKGRS", "length": 562, "header": "tr|A0AAF6Z555-1|A0AAF6Z555_BOVIN Isoform 1 of DNA polymerase gamma 2, accessory subunit OS=Bos taurus OX=9913 GN=POLG2 PE=4 SV=1 CANONICAL=A0AAF6Z555-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE9/entry", "sequence": { "sequence": "MRSAPAIRACQRICRCLLSGFGGQVDGRQPEQLSKGTGSFVGPVRSQAELPRNEPREAPESGGEGSEPLVEICRKRRFLSGTKQQLSRDSLLNGCHPGLGPLGIELRKNLAAEWWSSVVVFREQVFPVDALHREPGPSLPVDNGFRLVSAETLREILQDKELSKEQLVAFLENLLNTSGKLRENLLHGALEHYVSYLDLVNKRLPFGLAQIGACFHPVSDTKQTPDGVKRIGEKTEASLVWFTSARTASQWLDFWLRHRLLWWRKFAMSPSNFSSGDCQDEAGRKGNRLYYNFPWGKEPIETLWNLGDHELLHMYPGSVAQVHGRDGRKNVVPSVLSINGDLDRGMLAYLYDSFQLTENSFTRKKDLHRKVLKLHPCLAPIKAALDVGRGPTVELRQVCQGLFNELLENGISVWPGYLETVQSSLEQLYSKYDEMSILFTVLITEATLENGLIQLRSRDTTMKEMMHISKGPQASQEDCIPGLRSADCTNWQHGISKHQLGRSSTERRQSP", "length": 511, "header": "tr|A0AAA9RWE9-1|A0AAF6Z555_BOVIN Computationally mapped isoform of DNA polymerase gamma 2, accessory subunit OS=Bos taurus OX=9913 GN=POLG2 PE=4 SV=1 CANONICAL=A0AAF6Z555-1" }, "locus": { "chromosome": "19", "start_pos": 48676951, "end_pos": 48656319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123699.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123699.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075445.1" } ] } }, { "isoform_ac": "A0AAF6Z555-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555/entry", "sequence": { "sequence": "MRSAPAIRACQRICRCLLSGFGGQVDGRQPEQLSKGTGSFVGPVRSQAELPRNEPREAPESGGEGSEPLVEICRKRRFLSGTKQQLSRDSLLNGCHPGLGPLGIELRKNLAAEWWSSVVVFREQVFPVDALHREPGPSLPVDNGFRLVSAETLREILQDKELSKEQLVAFLENLLNTSGKLRENLLHGALEHYVSYLDLVNKRLPFGLAQIGACFHPVSDTKQTPDGVKRIGEKTEASLVWFTSARTASQWLDFWLRHRLLWWRKFAMSPSNFSSGDCQDEAGRKGNRLYYNFPWGKEPIETLWNLGDHELLHMYPGSVAQVHGRDGRKNVVPSVLSINGDLDRGMLAYLYDSFQLTENSFTRKKDLHRKVLKLHPCLAPIKAALDVGRGPTVELRQVCQGLFNELLENGISVWPGYLETVQSSLEQLYSKYDEMSILFTVLITEATLENGLIQLRSRDTTMKEMMHISKGPQASQEDCIPGLRSADCTNWQHGISKHQLGIQNARTRMIIISTNNNPGSRSCRQNGPQSPPGRRRRQHSLVTAQPAFPMILNCGMFWKGRS", "length": 562, "header": "tr|A0AAF6Z555-1|A0AAF6Z555_BOVIN Isoform 1 of DNA polymerase gamma 2, accessory subunit OS=Bos taurus OX=9913 GN=POLG2 PE=4 SV=1 CANONICAL=A0AAF6Z555-1" }, "locus": { "chromosome": "19", "start_pos": 48676951, "end_pos": 48634564, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024509.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024509.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024509.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024509.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 392, "start_aa": "Thr", "end_pos": 392, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr392", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "gamma DNA polymerase complex", "id": "GO:0005760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005760", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "mitochondrial DNA replication", "id": "GO:0006264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006264", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA polymerase processivity factor activity", "id": "GO:0030337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030337", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "DNA-directed DNA polymerase activity", "id": "GO:0003887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "DNA polymerase binding", "id": "GO:0070182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070182", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z555", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z555" }, { "id": "PF03129", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03129" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Anticodon-binding", "eco_id": "ECO_0000259", "start_pos": 392, "end_pos": 470, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 392 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 272, "end_pos": 274 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z660-1", "uniprot_ac": "A0AAF6Z660", "uniprot_id": "A0AAF6Z660_BOVIN", "mass": { "chemical_mass": 25365.0, "monoisotopic_mass": 25365.0 }, "refseq": {}, "gene_names": [ { "name": "DCTN3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ] } ], "protein_names": [ { "name": "Dynactin subunit 3", "type": "synonym", "evidence": [ { "id": "A0AAF6Z660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCTN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660", "locus": { "chromosome": "8", "start_pos": 75981745, "end_pos": 75990300, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018883", "url": "https://www.ensembl.org/id/ENSBTAG00000018883" } ] } } ], "crossref": [ { "id": "A0AAF6Z660", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z660", "database": "AlphaFoldDB", "categories": [] }, { "id": "514327", "url": "https://www.ncbi.nlm.nih.gov/gene/514327", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28360", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28360", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28360:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28360:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RWH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z660-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVTDVQRLQARVEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKVLYKKIEDLIKYLDPEYIDRIALPDASKLQFILAEEQFILSQVALLEQVEALVPMLDSTHIKESSASELRQFGPKDTQPFLSMLPACSAWPRSTSSSRTSVWRSLRSPRRSWRNTTRLYPFCSAGPLRSAILILTLTCDQTMLLSKQFVQWDELLCQLEAAKQVKPVEE", "length": 224, "header": "tr|A0AAF6Z660-1|A0AAF6Z660_BOVIN Isoform 1 of Dynactin subunit 3 OS=Bos taurus OX=9913 GN=DCTN3 PE=4 SV=1 CANONICAL=A0AAF6Z660-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWH5/entry", "sequence": { "sequence": "MAAVTDVQRLQARVEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKVLYKKIEDLIKYLDPEYIDRIALPDASKLQFILAEEQFILSQVALLEQVEALVPMLDSTHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTVSFLLSWTPEECYSHSHLDL", "length": 177, "header": "tr|A0AAA9RWH5-1|A0AAF6Z660_BOVIN Computationally mapped isoform of Dynactin subunit 3 OS=Bos taurus OX=9913 GN=DCTN3 PE=4 SV=1 CANONICAL=A0AAF6Z660-1" }, "locus": { "chromosome": "8", "start_pos": 75990297, "end_pos": 75982217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103445.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103445.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077795.1" } ] } }, { "isoform_ac": "A0AAA9STN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN0/entry", "sequence": { "sequence": "MAAVTDVQRLQARVEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKVLYKKIEDLIKYLDPEYIDRIALPDASKLQFILAAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAAKQVKPVEE", "length": 158, "header": "tr|A0AAA9STN0-1|A0AAF6Z660_BOVIN Computationally mapped isoform of Dynactin subunit 3 OS=Bos taurus OX=9913 GN=DCTN3 PE=4 SV=2 CANONICAL=A0AAF6Z660-1" }, "locus": { "chromosome": "8", "start_pos": 75990297, "end_pos": 75982123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087574.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087574.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086447.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086447.2" } ] } }, { "isoform_ac": "A0AAA9TCJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ9/entry", "sequence": { "sequence": "MAAVTDVQRLQARVEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKVLYKKIEDLIKYLDPEYIDRIALPDASKLQFILAEEQFILSQVALLEQVEALVPMLDSTHIKAVPEHAARLQRLAQIHIQQQILILTLTCDQTMLLSKQFVQWDELLCQLEAAKQVKPVEE", "length": 176, "header": "tr|A0AAA9TCJ9-1|A0AAF6Z660_BOVIN Computationally mapped isoform of Dynactin subunit 3 OS=Bos taurus OX=9913 GN=DCTN3 PE=4 SV=1 CANONICAL=A0AAF6Z660-1" }, "locus": { "chromosome": "8", "start_pos": 75990297, "end_pos": 75982123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101912.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101912.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093847.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093847.1" } ] } }, { "isoform_ac": "A0AAF6Z660-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660/entry", "sequence": { "sequence": "MAAVTDVQRLQARVEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKVLYKKIEDLIKYLDPEYIDRIALPDASKLQFILAEEQFILSQVALLEQVEALVPMLDSTHIKESSASELRQFGPKDTQPFLSMLPACSAWPRSTSSSRTSVWRSLRSPRRSWRNTTRLYPFCSAGPLRSAILILTLTCDQTMLLSKQFVQWDELLCQLEAAKQVKPVEE", "length": 224, "header": "tr|A0AAF6Z660-1|A0AAF6Z660_BOVIN Isoform 1 of Dynactin subunit 3 OS=Bos taurus OX=9913 GN=DCTN3 PE=4 SV=1 CANONICAL=A0AAF6Z660-1" }, "locus": { "chromosome": "8", "start_pos": 75990297, "end_pos": 75982123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025136.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025136.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025136.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025136.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "dynactin complex", "id": "GO:0005869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoskeleton-dependent cytokinesis", "id": "GO:0061640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061640", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z660", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z660" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9Q2-1", "uniprot_ac": "A0AAF6Z9Q2", "uniprot_id": "A0AAF6Z9Q2_BOVIN", "mass": { "chemical_mass": 30175.0, "monoisotopic_mass": 30175.0 }, "refseq": {}, "gene_names": [ { "name": "RWDD3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" } ] } ], "protein_names": [ { "name": "RWD domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RWDD3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2", "locus": { "chromosome": "3", "start_pos": 48239813, "end_pos": 48252557, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021537", "url": "https://www.ensembl.org/id/ENSBTAG00000021537" } ] } } ], "crossref": [ { "id": "A0AAF6Z9Q2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9Q2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23819", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23819", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd24164", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd24164", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038840", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038840", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15628", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15628", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15628:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15628:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S2R0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2R0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2R0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPVRQELSALAAIFCGPDEWEVLSLSDGAVFRILTKAEGFMDTDIPLQLVFHLPLSYPYCLPGIVVNSKHLTRAQCEIVKEKLLEQAETLLLEPMVHELVLWIQENLRHILKCPEAGGGSEKCSSAASMTVDDGLWMTLLHLDHMRAKAKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNDIKEYLILQKTCKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSSLDELQKEFETTGLKKLFSECVLRLVK", "length": 265, "header": "tr|A0AAF6Z9Q2-1|A0AAF6Z9Q2_BOVIN Isoform 1 of RWD domain-containing protein 3 OS=Bos taurus OX=9913 GN=RWDD3 PE=4 SV=1 CANONICAL=A0AAF6Z9Q2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2R0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2R0/entry", "sequence": { "sequence": "MAEPVRQELSALAAIFCGPDEWEVLSLSETDGAVFRILTKAEGFMDTDIPLQLVFHLPLSYPYCLPGIVVNSKHLTRAQCEIVKEKLLEQAETLLLEPMVHELVLWIQENLRHILKCPEAGGGSEKCSSAASMTVDDGLWMTLLHLDHMRAKAKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNDIKVPKSLMLNVNLAIFC", "length": 206, "header": "tr|A0AAA9S2R0-1|A0AAF6Z9Q2_BOVIN Computationally mapped isoform of RWD domain-containing protein 3 OS=Bos taurus OX=9913 GN=RWDD3 PE=4 SV=1 CANONICAL=A0AAF6Z9Q2-1" }, "locus": { "chromosome": "3", "start_pos": 48252358, "end_pos": 48242629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078011.1" } ] } }, { "isoform_ac": "A0AAF6Z9Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2/entry", "sequence": { "sequence": "MAEPVRQELSALAAIFCGPDEWEVLSLSDGAVFRILTKAEGFMDTDIPLQLVFHLPLSYPYCLPGIVVNSKHLTRAQCEIVKEKLLEQAETLLLEPMVHELVLWIQENLRHILKCPEAGGGSEKCSSAASMTVDDGLWMTLLHLDHMRAKAKYVKTVEKWASDLRLTGRLMFMGKIILILLQGDRNDIKEYLILQKTCKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSSLDELQKEFETTGLKKLFSECVLRLVK", "length": 265, "header": "tr|A0AAF6Z9Q2-1|A0AAF6Z9Q2_BOVIN Isoform 1 of RWD domain-containing protein 3 OS=Bos taurus OX=9913 GN=RWDD3 PE=4 SV=1 CANONICAL=A0AAF6Z9Q2-1" }, "locus": { "chromosome": "3", "start_pos": 48252358, "end_pos": 48240369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028701.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028701.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028701.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028701.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of hypoxia-inducible factor-1alpha signaling pathway", "id": "GO:1902073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902073", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" } ], "pmid": "" }, { "name": "positive regulation of protein sumoylation", "id": "GO:0033235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033235", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Q2" }, { "id": "PS50908", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RWD", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 112, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A3J8-1", "uniprot_ac": "A0AAF7A3J8", "uniprot_id": "A0AAF7A3J8_BOVIN", "mass": { "chemical_mass": 53735.0, "monoisotopic_mass": 53735.0 }, "refseq": { "ac": "XP_059744254", "name": "stimulator of interferon genes protein isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744254" }, "gene_names": [ { "name": "STING1", "type": "recommended", "evidence": [ { "id": "A0AAF7A3J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ] }, { "name": "STING1", "type": "synonym", "evidence": [ { "id": "XP_059744254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744254" } ] }, { "name": "STING", "type": "synonym", "evidence": [ { "id": "XP_059744254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744254" } ] }, { "name": "TMEM173", "type": "synonym", "evidence": [ { "id": "XP_059744254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744254" } ] } ], "protein_names": [ { "name": "Stimulator of interferon genes protein", "type": "recommended", "evidence": [ { "id": "A0AAF7A3J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8/entry#names_and_taxonomy" } ] }, { "name": "stimulator of interferon genes protein isoform X3", "type": "synonym", "evidence": [ { "id": "XP_059744254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744254" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STING1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8", "locus": { "chromosome": "7", "start_pos": 50736654, "end_pos": 50742462, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002296", "url": "https://www.ensembl.org/id/ENSBTAG00000002296" } ] } } ], "crossref": [ { "id": "A0AAF7A3J8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A3J8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22658", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22658", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533661", "url": "https://www.ncbi.nlm.nih.gov/gene/533661", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055432", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055432", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR34339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34339:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34339:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23417", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23417", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059744254", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744254", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "34979", "url": "https://www.rhea-db.org/rhea/34979", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S3J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T821", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T821", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T821-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T821-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJD5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A3J8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDFLHPHGLRHARLPCPSLFPRVCSNSCVHAFLSPPTLFATNLFGLELWDAVCPTCPLEVSPGAFSGYGWAPGNWRAGGYAHSGPQSWNCRRVRGEQPWISWYPQMPHSSLHPSIPQPRGLRAQKAALVLLSACLVALWGLGEPPDYTLKWLVLHLASQQMGLLIKGICSLAEELCHVHSRYHGSYWRAVRACLCSSMRCGALLLLSCYFYCSLPNMADLPFTWMLALLGLSQALNILLGLQGLAPAEVSAICEKRNFNVAHGLAWSYYIGYLRLILPGLPARIQIYNQFHNNTLQGAGSHRLHILFPLDCGVPDDLNVADPNIRFLHELPQQSADRAGIKGRVYTNSIYELLENGQRAGVCVLEYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILANAPESQNNCRLIVYQEPAEGSSFSLSQEILQHLRQEEREVTMGSTETSVMPGSSVLSQEPELLISGLEKPLPLRSDVF", "length": 484, "header": "tr|A0AAF7A3J8-1|A0AAF7A3J8_BOVIN Isoform 1 of Stimulator of interferon genes protein OS=Bos taurus OX=9913 GN=STING1 PE=3 SV=1 CANONICAL=A0AAF7A3J8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3J6/entry", "sequence": { "sequence": "MSDFLHPHGLRHARLPCPSLFPRVCSNSCVHAFLSPPTLFATNLFGLELWDAVCPTCPLEVSPGAFSGYGWAPGNWRAGGYAHSGPQSWNCRRVRGEQPWISWYPQMPHSSLHPSIPQPRGLRAQKAALVLLSACLVALWGLGEPPDYTLKWLVLHLASQQMGLLIKGICSLAEELCHVHSRYHGSYWRAVRACLCSSMRCGALLLLSCYFYCSLPNMADLPFTWMLALLGLSQALNILLGLQAGVCVLEYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILANAPESQNNCRLIVYQEPAEGSSFSLSQEILQHLRQEEREVTMGSTETSVMPGSSVLSQEPELLISGLEKPLPLRSDVF", "length": 368, "header": "tr|A0AAA9S3J6-1|A0AAF7A3J8_BOVIN Computationally mapped isoform of Stimulator of interferon genes protein OS=Bos taurus OX=9913 GN=STING1 PE=3 SV=1 CANONICAL=A0AAF7A3J8-1" }, "locus": { "chromosome": "7", "start_pos": 50742263, "end_pos": 50737881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097419.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097419.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077838.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077838.1" } ] } }, { "isoform_ac": "A0AAA9T821-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T821/entry", "sequence": { "sequence": "MSDFLHPHGLRHARLPCPSLFPRVCSNSCVHAFLSPPTLFATNLFGLELWDAVCPTCPLEVSPGAFSGYGWAPGNWRAGGYAHSGPQSWNCRRVRGEQPWISWYPQMPHSSLHPSIPQPRGLRAQKAALVLLSACLVALWGLGEPPDYTLKWLVLHLASQQMGLLIKGICSLAEELCHVHSRYHGSYWRAVRACLCSSMRCGALLLLSCYFYCSLPNMADLPFTWMLALLGLSQALNILLGLQGLAPAEVSAICEKRNFNVAHGLAWSYYIGYLRLILPGLPARIQIYNQFHNNTLQGAGSHRLHILFPLDCGVPDDLNVADPNIRFLHELPQQSADRAGIKGRVYTNSIYELLENGQRNLQREAASPCHRKFSSTFGRRKGRLPWVAQ", "length": 389, "header": "tr|A0AAA9T821-1|A0AAF7A3J8_BOVIN Computationally mapped isoform of Stimulator of interferon genes protein OS=Bos taurus OX=9913 GN=STING1 PE=3 SV=1 CANONICAL=A0AAF7A3J8-1" }, "locus": { "chromosome": "7", "start_pos": 50742263, "end_pos": 50737979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120986.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120986.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092942.1" } ] } }, { "isoform_ac": "A0AAF6YJD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJD5/entry", "sequence": { "sequence": "MPHSSLHPSIPQPRGLRAQKAALVLLSACLVALWGLGEPPDYTLKWLVLHLASQQMGLLIKGICSLAEELCHVHSRYHGSYWRAVRACLCSSMRCGALLLLSCYFYCSLPNMADLPFTWMLALLGLSQALNILLGLQGLAPAEVSAICEKRNFNVAHGLAWSYYIGYLRLILPGLPARIQIYNQFHNNTLQGAGSHRLHILFPLDCGVPDDLNVADPNIRFLHELPQQSADRAGIKGRVYTNSIYELLENGQRNLQREAASPCHRKFSSTFGRRKGRLPWVAQ", "length": 283, "header": "tr|A0AAF6YJD5-1|A0AAF7A3J8_BOVIN Computationally mapped isoform of Stimulator of interferon genes protein OS=Bos taurus OX=9913 GN=STING1 PE=3 SV=1 CANONICAL=A0AAF7A3J8-1" }, "locus": { "chromosome": "7", "start_pos": 50741945, "end_pos": 50737979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002962.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002962.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002962.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002962.3" } ] } }, { "isoform_ac": "A0AAF7A3J8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8/entry", "sequence": { "sequence": "MSDFLHPHGLRHARLPCPSLFPRVCSNSCVHAFLSPPTLFATNLFGLELWDAVCPTCPLEVSPGAFSGYGWAPGNWRAGGYAHSGPQSWNCRRVRGEQPWISWYPQMPHSSLHPSIPQPRGLRAQKAALVLLSACLVALWGLGEPPDYTLKWLVLHLASQQMGLLIKGICSLAEELCHVHSRYHGSYWRAVRACLCSSMRCGALLLLSCYFYCSLPNMADLPFTWMLALLGLSQALNILLGLQGLAPAEVSAICEKRNFNVAHGLAWSYYIGYLRLILPGLPARIQIYNQFHNNTLQGAGSHRLHILFPLDCGVPDDLNVADPNIRFLHELPQQSADRAGIKGRVYTNSIYELLENGQRAGVCVLEYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILANAPESQNNCRLIVYQEPAEGSSFSLSQEILQHLRQEEREVTMGSTETSVMPGSSVLSQEPELLISGLEKPLPLRSDVF", "length": 484, "header": "tr|A0AAF7A3J8-1|A0AAF7A3J8_BOVIN Isoform 1 of Stimulator of interferon genes protein OS=Bos taurus OX=9913 GN=STING1 PE=3 SV=1 CANONICAL=A0AAF7A3J8-1" }, "locus": { "chromosome": "7", "start_pos": 50742263, "end_pos": 50737881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071484.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071484.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062677.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062677.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 56, "start_aa": "Thr", "end_pos": 56, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr56", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "id": "GO:0033116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033116", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "monoatomic ion transmembrane transport", "id": "GO:0034220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034220", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "activation of innate immune response", "id": "GO:0002218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002218", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "cellular response to exogenous dsRNA", "id": "GO:0071360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071360", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "protein complex oligomerization", "id": "GO:0051259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051259", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "positive regulation of defense response to virus by host", "id": "GO:0002230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "positive regulation of macroautophagy", "id": "GO:0016239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016239", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "protein localization to endoplasmic reticulum", "id": "GO:0070972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070972", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "positive regulation of type I interferon-mediated signaling pathway", "id": "GO:0060340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "cGAS/STING signaling pathway", "id": "GO:0140896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140896", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "proton channel activity", "id": "GO:0015252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "cyclic-di-GMP binding", "id": "GO:0035438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035438", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "2',3'-cyclic GMP-AMP binding", "id": "GO:0061507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061507", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A3J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "34979", "name": "", "equation": "H(+)(in) = H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "34979", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34979" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7A3J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" }, { "id": "PF15009", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15009" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "STING ligand-binding", "eco_id": "ECO_0000259", "start_pos": 260, "end_pos": 443, "start_aa": "Asn", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF7A3J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A3J8" }, { "id": "PF23417", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23417" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "STING transmembrane", "eco_id": "ECO_0000259", "start_pos": 150, "end_pos": 258, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 56 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 293, "end_pos": 295 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZDK8-1", "uniprot_ac": "A0AAF6ZDK8", "uniprot_id": "A0AAF6ZDK8_BOVIN", "mass": { "chemical_mass": 52134.0, "monoisotopic_mass": 52134.0 }, "refseq": { "ac": "XP_005209829", "name": "NAD-capped RNA hydrolase NUDT12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209829" }, "gene_names": [ { "name": "NUDT12", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ] }, { "name": "NUDT12", "type": "synonym", "evidence": [ { "id": "XP_005209829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209829" } ] } ], "protein_names": [ { "name": "NAD-capped RNA hydrolase NUDT12", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.22", "type": "synonym", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8/entry#names_and_taxonomy" } ] }, { "name": "NAD-capped RNA hydrolase NUDT12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209829" } ] }, { "name": "NADH pyrophosphatase NUDT12", "type": "synonym", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8/entry#names_and_taxonomy" } ] }, { "name": "Nucleoside diphosphate-linked moiety X motif 12", "type": "synonym", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8#function" }, { "database": "UniProtKB", "id": "ARBA00045837", "url": "https://www.uniprot.org/uniprotkb/ARBA00045837#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT12", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8", "locus": { "chromosome": "7", "start_pos": 102607083, "end_pos": 102621123, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027728", "url": "https://www.ensembl.org/id/ENSBTAG00000027728" } ] } } ], "crossref": [ { "id": "A0AAF6ZDK8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZDK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03429", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03429", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617720", "url": "https://www.ncbi.nlm.nih.gov/gene/617720", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42904", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42904", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42904:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42904:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00293", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00293", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209829", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11800", "url": "https://www.rhea-db.org/rhea/11800", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48868", "url": "https://www.rhea-db.org/rhea/48868", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60820", "url": "https://www.rhea-db.org/rhea/60820", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60876", "url": "https://www.rhea-db.org/rhea/60876", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S4K0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSVKRSLNQEIISQFHYSAAEGDIAKLTAILSHSPSLLNETSENGWSALMYAARNGHPDVVQFLLEKGCDRSIVNKSRQTALDIAKFWGYKHIANLLANAKGGKKPWFLTNEVEECENYFSKTLLDRKSEKRNNSDWLLAKESHPATVYILFSDLNPLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITLIFLGVELEMKKEFFNYAGEISKEEEDGLVAWFALGIDTVAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKRVCLKEDCPSLHGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVSCQPWPMPSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQAFFVPPSRAIAHQLIKHWIGMNPNL", "length": 462, "header": "tr|A0AAF6ZDK8-1|A0AAF6ZDK8_BOVIN Isoform 1 of NAD-capped RNA hydrolase NUDT12 OS=Bos taurus OX=9913 GN=NUDT12 PE=3 SV=1 CANONICAL=A0AAF6ZDK8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K0/entry", "sequence": { "sequence": "MSSVKRSLNQEIISQFHYSAAEGDIAKLTAILSHSPSLLNETSENGWSALMYAARNGHPDVVQFLLEKGCDRSIVNKSRQTALDIAKFWGYKHIANLLANAKGGKKPWFLTNEVEECENYFSKTLLDRKSEKRNNSDWLLAKESHPATVYILFSDLNPLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITLIFLGVELEMKKEFFNYAGEISKEEEDGLVAWFALGIDTVAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKRVCLKEDCPSLHGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPVPVIQSDFSLEHSSAPNRVYMGDNRRRCSERSRRGKWSQSWPCSVCLLSTVANALFLNDWLLSCGSVYRN", "length": 429, "header": "tr|A0AAA9S4K0-1|A0AAF6ZDK8_BOVIN Computationally mapped isoform of NAD-capped RNA hydrolase NUDT12 OS=Bos taurus OX=9913 GN=NUDT12 PE=3 SV=1 CANONICAL=A0AAF6ZDK8-1" }, "locus": { "chromosome": "7", "start_pos": 102618435, "end_pos": 102610125, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091105.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091105.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080861.1" } ] } }, { "isoform_ac": "A0AAF6ZDK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8/entry", "sequence": { "sequence": "MSSVKRSLNQEIISQFHYSAAEGDIAKLTAILSHSPSLLNETSENGWSALMYAARNGHPDVVQFLLEKGCDRSIVNKSRQTALDIAKFWGYKHIANLLANAKGGKKPWFLTNEVEECENYFSKTLLDRKSEKRNNSDWLLAKESHPATVYILFSDLNPLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITLIFLGVELEMKKEFFNYAGEISKEEEDGLVAWFALGIDTVAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKRVCLKEDCPSLHGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVSCQPWPMPSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQAFFVPPSRAIAHQLIKHWIGMNPNL", "length": 462, "header": "tr|A0AAF6ZDK8-1|A0AAF6ZDK8_BOVIN Isoform 1 of NAD-capped RNA hydrolase NUDT12 OS=Bos taurus OX=9913 GN=NUDT12 PE=3 SV=1 CANONICAL=A0AAF6ZDK8-1" }, "locus": { "chromosome": "7", "start_pos": 102618435, "end_pos": 102609013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039965.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039965.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039749.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039749.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "NAD+ diphosphatase activity", "id": "GO:0000210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000210", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "NADH pyrophosphatase activity", "id": "GO:0035529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035529", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "phosphodiesterase decapping endonuclease activity", "id": "GO:1990174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990174", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "NAD+ catabolic process", "id": "GO:0019677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "NADP+ catabolic process", "id": "GO:0006742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006742", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "NAD-cap decapping", "id": "GO:0110155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110155", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" }, { "name": "mRNA methylguanosine-cap decapping", "id": "GO:0110156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110156", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11800", "name": "", "equation": "NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1", "A0AAA9SPZ1-1" ], "evidence": [ { "id": "11800", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11800" } ] }, { "id": "48868", "name": "", "equation": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1", "A0AAA9SPZ1-1", "F6R6Q1-1", "A0AAA9TEH3-1" ], "evidence": [ { "id": "48868", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48868" } ] }, { "id": "60820", "name": "", "equation": "NADPH + H2O = reduced beta-nicotinamide D-ribonucleotide + adenosine 2',5'-bisphosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1", "A0AAA9SPZ1-1" ], "evidence": [ { "id": "60820", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60820" } ] }, { "id": "60876", "name": "", "equation": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1" ], "evidence": [ { "id": "60876", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60876" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SPZ1", "gene_name": "NUDT13", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ] }, { "ec_number": "3.6.1.22", "activity": "", "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ] } ] }, { "uniprot_ac": "A0AAA9TEH3", "gene_name": "NUDT6", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH3" } ] } ] }, { "uniprot_ac": "A0AAF6ZDK8", "gene_name": "NUDT12", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ] }, { "ec_number": "3.6.1.22", "activity": "", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ] } ] }, { "uniprot_ac": "F6R6Q1", "gene_name": "FLAD1", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "2.7.7.2", "activity": "FMN + ATP + H(+) = FAD + diphosphate.", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "3.6.1.18", "activity": "FAD + H2O = FMN + AMP + 2 H(+).", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "3.6.1.22", "activity": "", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "2.7.7.2", "activity": "", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "3.6.1.18", "activity": "", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] } ] }, { "uniprot_ac": "Q29RH3", "gene_name": "NUDT12", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "Q29RH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH3" } ] }, { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q29RH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH3" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 319, "end_pos": 453, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.22", "ec_name": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "3.6.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22" }, { "id": "3.6.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 289, "end_pos": 291 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z791-1", "uniprot_ac": "A0AAF6Z791", "uniprot_id": "A0AAF6Z791_BOVIN", "mass": { "chemical_mass": 34997.0, "monoisotopic_mass": 34997.0 }, "refseq": {}, "gene_names": [ { "name": "PRPS1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ] } ], "protein_names": [ { "name": "Ribose-phosphate pyrophosphokinase 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791/entry#names_and_taxonomy" } ] }, { "name": "2.7.6.1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791/entry#names_and_taxonomy" } ] }, { "name": "Phosphoribosyl pyrophosphate synthase I", "type": "synonym", "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791#function" }, { "database": "UniProtKB", "id": "ARBA00003018", "url": "https://www.uniprot.org/uniprotkb/ARBA00003018#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRPS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791", "locus": { "chromosome": "X", "start_pos": 56262495, "end_pos": 56240053, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019703", "url": "https://www.ensembl.org/id/ENSBTAG00000019703" } ] } } ], "crossref": [ { "id": "A0AAF6Z791", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z791", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10210", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10210", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10210:SF118", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10210:SF118", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14572", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14572", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "15609", "url": "https://www.rhea-db.org/rhea/15609", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S4Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z791-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRYVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL", "length": 319, "header": "tr|A0AAF6Z791-1|A0AAF6Z791_BOVIN Isoform 1 of Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=PRPS1 PE=3 SV=1 CANONICAL=A0AAF6Z791-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y5/entry", "sequence": { "sequence": "MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGD", "length": 121, "header": "tr|A0AAA9S4Y5-1|A0AAF6Z791_BOVIN Computationally mapped isoform of Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=PRPS1 PE=3 SV=1 CANONICAL=A0AAF6Z791-1" }, "locus": { "chromosome": "X", "start_pos": 56261438, "end_pos": 56240205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089423.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089423.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080997.1" } ] } }, { "isoform_ac": "A0AAA9TGA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA1/entry", "sequence": { "sequence": "MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL", "length": 285, "header": "tr|A0AAA9TGA1-1|A0AAF6Z791_BOVIN Computationally mapped isoform of Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=PRPS1 PE=3 SV=1 CANONICAL=A0AAF6Z791-1" }, "locus": { "chromosome": "X", "start_pos": 56261523, "end_pos": 56240205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113382.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113382.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095896.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095896.1" } ] } }, { "isoform_ac": "A0AAF6Z791-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791/entry", "sequence": { "sequence": "MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRYVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL", "length": 319, "header": "tr|A0AAF6Z791-1|A0AAF6Z791_BOVIN Isoform 1 of Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus OX=9913 GN=PRPS1 PE=3 SV=1 CANONICAL=A0AAF6Z791-1" }, "locus": { "chromosome": "X", "start_pos": 56261523, "end_pos": 56240205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026261.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026261.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026261.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026261.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "ribose phosphate diphosphokinase activity", "id": "GO:0004749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004749", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "nucleotide biosynthetic process", "id": "GO:0009165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "ribonucleoside monophosphate biosynthetic process", "id": "GO:0009156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009156", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "urate biosynthetic process", "id": "GO:0034418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034418", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "purine nucleotide biosynthetic process", "id": "GO:0006164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006164", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" }, { "name": "hypoxanthine biosynthetic process", "id": "GO:0046101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046101", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z791", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15609", "name": "", "equation": "D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MHS1-1", "Q2HJ58-1", "A0AAF6Z791-1" ], "evidence": [ { "id": "15609", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15609" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MHS1", "gene_name": "PRPS2", "activity": [ { "ec_number": "2.7.6.1", "activity": "D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+).", "evidence": [ { "id": "A0A3Q1MHS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHS1" } ] }, { "ec_number": "2.7.6.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHS1" } ] } ] }, { "uniprot_ac": "A0AAF6Z791", "gene_name": "PRPS1", "activity": [ { "ec_number": "2.7.6.1", "activity": "D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+).", "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ] }, { "ec_number": "2.7.6.1", "activity": "", "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" } ] } ] }, { "uniprot_ac": "Q2HJ58", "gene_name": "PRPS1", "activity": [ { "ec_number": "2.7.6.1", "activity": "D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+).", "evidence": [ { "id": "Q2HJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ58" } ] }, { "ec_number": "2.7.6.1", "activity": "", "evidence": [ { "id": "Q2HJ58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ58" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z791" }, { "id": "PF13793", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13793" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ribose-phosphate pyrophosphokinase N-terminal", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 120, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.6.1", "ec_name": "D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+).", "evidence": [ { "id": "2.7.6.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1" }, { "id": "2.7.6.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.6.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 164, "end_pos": 166 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9R8-1", "uniprot_ac": "A0AAF6Z9R8", "uniprot_id": "A0AAF6Z9R8_BOVIN", "mass": { "chemical_mass": 17803.0, "monoisotopic_mass": 17803.0 }, "refseq": {}, "gene_names": [ { "name": "TAC3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ] } ], "protein_names": [ { "name": "Tachykinin 3", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Is a ligand for TACR3, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Binding to TACR3 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). Is a critical central regulator of gonadal function.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQK6#function" }, { "database": "UniProtKB", "id": "ARBA00094506", "url": "https://www.uniprot.org/uniprotkb/ARBA00094506#function" }, { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8#function" } ] }, { "annotation": "Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQK6#function" }, { "database": "UniProtKB", "id": "ARBA00003207", "url": "https://www.uniprot.org/uniprotkb/ARBA00003207#function" }, { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8#function" }, { "database": "UniProtKB", "id": "A0AAA9S546", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S546#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAC3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8", "locus": { "chromosome": "5", "start_pos": 56418012, "end_pos": 56409686, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021807", "url": "https://www.ensembl.org/id/ENSBTAG00000021807" } ] } } ], "crossref": [ { "id": "A0AAF6Z9R8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9R8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15536", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15536", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15536:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15536:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03823", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03823", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S546", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S546", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S546-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S546-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFSSSSTSSVRGERAVLPASSLILLDHLSQAPSCSTGIMRSTLLFAVILALSSARSLGAVCEESQEQVVPGGGHSKKDSNLYQLPPSLLRRLYDSRVVSLDGLLKMLSKASVGPKESPLPQKRDMHDFFVGLMGKRNLQPDTPVDINQENIPSFGTFKYPPSVE", "length": 165, "header": "tr|A0AAF6Z9R8-1|A0AAF6Z9R8_BOVIN Isoform 1 of Tachykinin 3 OS=Bos taurus OX=9913 GN=TAC3 PE=3 SV=1 CANONICAL=A0AAF6Z9R8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S546-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S546/entry", "sequence": { "sequence": "MRSTLLFAVILALSSARSLGAVCEESQEQVVPGGGHSKKDSNLYQLPPSLLRRLYDSRVVSLDGLLKMLSKASVGPKESPLPQKHTPVDINQENIPSFGTFKYPPSVE", "length": 108, "header": "tr|A0AAA9S546-1|A0AAF6Z9R8_BOVIN Computationally mapped isoform of Tachykinin 3 OS=Bos taurus OX=9913 GN=TAC3 PE=3 SV=1 CANONICAL=A0AAF6Z9R8-1" }, "locus": { "chromosome": "5", "start_pos": 56415589, "end_pos": 56411955, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110930.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110930.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077274.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077274.1" } ] } }, { "isoform_ac": "A0AAA9SQK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQK6/entry", "sequence": { "sequence": "WAGNLAGGSCYTSSKRPEPVQKTQSKCQTKAGHCVRSQSFSWRPNIWKDSNLYQLPPSLLRRLYDSRVVSLDGLLKMLSKASVGPKESPLPQKRDMHDFFVGLMGKRNLQPDTPVDINQENIPSFGTFKYPPSVE", "length": 135, "header": "tr|A0AAA9SQK6-1|A0AAF6Z9R8_BOVIN Computationally mapped isoform of Tachykinin 3 OS=Bos taurus OX=9913 GN=TAC3 PE=3 SV=1 CANONICAL=A0AAF6Z9R8-1" }, "locus": { "chromosome": "5", "start_pos": 56415589, "end_pos": 56413012, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132159.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132159.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086221.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086221.1" } ] } }, { "isoform_ac": "A0AAF6Z9R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8/entry", "sequence": { "sequence": "MGFSSSSTSSVRGERAVLPASSLILLDHLSQAPSCSTGIMRSTLLFAVILALSSARSLGAVCEESQEQVVPGGGHSKKDSNLYQLPPSLLRRLYDSRVVSLDGLLKMLSKASVGPKESPLPQKRDMHDFFVGLMGKRNLQPDTPVDINQENIPSFGTFKYPPSVE", "length": 165, "header": "tr|A0AAF6Z9R8-1|A0AAF6Z9R8_BOVIN Isoform 1 of Tachykinin 3 OS=Bos taurus OX=9913 GN=TAC3 PE=3 SV=1 CANONICAL=A0AAF6Z9R8-1" }, "locus": { "chromosome": "5", "start_pos": 56415589, "end_pos": 56410068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029067.3", "url": "https://www.ensembl.org/id/ENSBTAT00000029067.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029067.2", "url": "https://www.ensembl.org/id/ENSBTAP00000029067.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "pmid": "" }, { "name": "tachykinin receptor signaling pathway", "id": "GO:0007217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007217", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "pmid": "" }, { "name": "phospholipase C-activating tachykinin receptor signaling pathway", "id": "GO:0007209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007209", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9R8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZA20-1", "uniprot_ac": "A0AAF6ZA20", "uniprot_id": "A0AAF6ZA20_BOVIN", "mass": { "chemical_mass": 25359.0, "monoisotopic_mass": 25359.0 }, "refseq": {}, "gene_names": [ { "name": "UXT", "type": "recommended", "evidence": [ { "id": "A0AAF6ZA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ] } ], "protein_names": [ { "name": "Protein UXT", "type": "recommended", "evidence": [ { "id": "A0AAF6ZA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitously expressed transcript protein", "type": "synonym", "evidence": [ { "id": "A0AAF6ZA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UXT", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20", "locus": { "chromosome": "X", "start_pos": 86023688, "end_pos": 86089900, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015820", "url": "https://www.ensembl.org/id/ENSBTAG00000015820" } ] } } ], "crossref": [ { "id": "A0AAF6ZA20", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZA20", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23158", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23158", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13345:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13345:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S561", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S561", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S561-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S561-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQIRSWRNPWKRLNKQGPKDRLTPPGYLVGQRPRRTSFTRATRKPRFLLTVLFAGGFQEPIMATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQEANHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDNLTKDSMNIKAHIHMLLEGLRELQGLQNFPETQH", "length": 218, "header": "tr|A0AAF6ZA20-1|A0AAF6ZA20_BOVIN Isoform 1 of Protein UXT OS=Bos taurus OX=9913 GN=UXT PE=3 SV=1 CANONICAL=A0AAF6ZA20-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S561-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S561/entry", "sequence": { "sequence": "MAQIRSWRNPWKRLNKQGPKEPIMATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQEANHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDNLTKDSMNIKAHIHMLLEGLRELQGLQNFPETQH", "length": 179, "header": "tr|A0AAA9S561-1|A0AAF6ZA20_BOVIN Computationally mapped isoform of Protein UXT OS=Bos taurus OX=9913 GN=UXT PE=3 SV=1 CANONICAL=A0AAF6ZA20-1" }, "locus": { "chromosome": "X", "start_pos": 86039531, "end_pos": 86023731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088663.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088663.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080318.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080318.1" } ] } }, { "isoform_ac": "A0AAF6ZA20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20/entry", "sequence": { "sequence": "MAQIRSWRNPWKRLNKQGPKDRLTPPGYLVGQRPRRTSFTRATRKPRFLLTVLFAGGFQEPIMATPPKRRAVEATAEKVLRYEAFISDVLQRDLQKVLDHRDKVYEQLAKYLQLRNVIERLQEANHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDNLTKDSMNIKAHIHMLLEGLRELQGLQNFPETQH", "length": 218, "header": "tr|A0AAF6ZA20-1|A0AAF6ZA20_BOVIN Isoform 1 of Protein UXT OS=Bos taurus OX=9913 GN=UXT PE=3 SV=1 CANONICAL=A0AAF6ZA20-1" }, "locus": { "chromosome": "X", "start_pos": 86039531, "end_pos": 86023731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030053.4", "url": "https://www.ensembl.org/id/ENSBTAT00000030053.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030041.3", "url": "https://www.ensembl.org/id/ENSBTAP00000030041.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" }, { "name": "centrosome cycle", "id": "GO:0007098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007098", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" }, { "name": "beta-tubulin binding", "id": "GO:0048487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048487", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 185, "end_pos": 187 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZE24-1", "uniprot_ac": "A0AAF6ZE24", "uniprot_id": "A0AAF6ZE24_BOVIN", "mass": { "chemical_mass": 31957.0, "monoisotopic_mass": 31957.0 }, "refseq": {}, "gene_names": [ { "name": "MTFR1L", "type": "recommended", "evidence": [ { "id": "A0AAF6ZE24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24" } ] } ], "protein_names": [ { "name": "Mitochondrial fission regulator", "type": "recommended", "evidence": [ { "id": "A0AAF6ZE24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L1#function" }, { "database": "UniProtKB", "id": "ARBA00044937", "url": "https://www.uniprot.org/uniprotkb/ARBA00044937#function" }, { "database": "UniProtKB", "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24#function" } ] }, { "annotation": "Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L1#function" }, { "database": "UniProtKB", "id": "RU369053", "url": "https://www.uniprot.org/uniprotkb/RU369053#function" }, { "database": "UniProtKB", "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTFR1L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24", "locus": { "chromosome": "2", "start_pos": 127238786, "end_pos": 127253787, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021781", "url": "https://www.ensembl.org/id/ENSBTAG00000021781" } ] } } ], "crossref": [ { "id": "A0AAF6ZE24", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZE24", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14215:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14215:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05308", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05308", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZE24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TSGMEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEIEVPELPSVPLLCSASPECCKPEHKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLSRSSLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 292, "header": "tr|A0AAF6ZE24-1|A0AAF6ZE24_BOVIN Isoform 1 of Mitochondrial fission regulator OS=Bos taurus OX=9913 GN=MTFR1L PE=3 SV=1 CANONICAL=A0AAF6ZE24-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L1/entry", "sequence": { "sequence": "MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEIEVPELPSVPLLCSASPECCKPEHKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLWQPPGSPVPGILQARTVECVAISFSNA", "length": 282, "header": "tr|A0AAA9S5L1-1|A0AAF6ZE24_BOVIN Computationally mapped isoform of Mitochondrial fission regulator OS=Bos taurus OX=9913 GN=MTFR1L PE=3 SV=1 CANONICAL=A0AAF6ZE24-1" }, "locus": { "chromosome": "2", "start_pos": 127250290, "end_pos": 127241605, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088029.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088029.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078563.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078563.1" } ] } }, { "isoform_ac": "A0AAF6ZE24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24/entry", "sequence": { "sequence": "TSGMEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEIEVPELPSVPLLCSASPECCKPEHKATCSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLSRSSLKEEDPAVLISEVLRRKFALKEEDISRKGN", "length": 292, "header": "tr|A0AAF6ZE24-1|A0AAF6ZE24_BOVIN Isoform 1 of Mitochondrial fission regulator OS=Bos taurus OX=9913 GN=MTFR1L PE=3 SV=1 CANONICAL=A0AAF6ZE24-1" }, "locus": { "chromosome": "2", "start_pos": 127250299, "end_pos": 127239675, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042894.3", "url": "https://www.ensembl.org/id/ENSBTAT00000042894.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040498.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040498.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial fission", "id": "GO:0000266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000266", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZE24", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1E4-1", "uniprot_ac": "A0AAF6Z1E4", "uniprot_id": "A0AAF6Z1E4_BOVIN", "mass": { "chemical_mass": 69255.0, "monoisotopic_mass": 69255.0 }, "refseq": {}, "gene_names": [ { "name": "TOX4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ] } ], "protein_names": [ { "name": "TOX high mobility group box family member 4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L3#function" }, { "database": "UniProtKB", "id": "ARBA00093329", "url": "https://www.uniprot.org/uniprotkb/ARBA00093329#function" }, { "database": "UniProtKB", "id": "A0AAA9TVF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVF0#function" }, { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOX4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4", "locus": { "chromosome": "10", "start_pos": 25677580, "end_pos": 25693453, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015146", "url": "https://www.ensembl.org/id/ENSBTAG00000015146" } ] } } ], "crossref": [ { "id": "A0AAF6Z1E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21995", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21995", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515314", "url": "https://www.ncbi.nlm.nih.gov/gene/515314", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45781", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45781", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45781:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45781:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T085", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T085", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T085-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T085-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPAPKPRLGCFGSPPQLEDCRPQVTCVSDDDFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEEFRRQPPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVDMDPAPPSQTPSPPPVAAADPASPAPASTEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKFRINLQQQPPPLQVKIVPPPTLKMQTTLVPPPVESSPEQPVNNSPETHTVEETTPETICEMITDVVPEVESPSQMDVELVSGSPMTLSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK", "length": 649, "header": "tr|A0AAF6Z1E4-1|A0AAF6Z1E4_BOVIN Isoform 1 of TOX high mobility group box family member 4 OS=Bos taurus OX=9913 GN=TOX4 PE=4 SV=1 CANONICAL=A0AAF6Z1E4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L3/entry", "sequence": { "sequence": "METFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEEFRRQPPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVDMDPAPPSQTPSPPPVAAADPASPAPASTEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKFRINLQQQPPPLQVKIVPPPTLKMQTTLVPPPVESSPEQPVNNSPETHTVEETTPETICEMITDVVPEVESPSQMDVELVSGSPMTLSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK", "length": 596, "header": "tr|A0AAA9S6L3-1|A0AAF6Z1E4_BOVIN Computationally mapped isoform of TOX high mobility group box family member 4 OS=Bos taurus OX=9913 GN=TOX4 PE=4 SV=1 CANONICAL=A0AAF6Z1E4-1" }, "locus": { "chromosome": "10", "start_pos": 25692914, "end_pos": 25678304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097611.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097611.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080831.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080831.1" } ] } }, { "isoform_ac": "A0AAA9T085-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T085/entry", "sequence": { "sequence": "MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKFRINLQQQPPPLQVKIVPPPTLKMQTTLVPPPVESSPEQPVNNSPETHTVEETTPETICEMITDVVPEVESPSQMDVELVSGSPMTLSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK", "length": 377, "header": "tr|A0AAA9T085-1|A0AAF6Z1E4_BOVIN Computationally mapped isoform of TOX high mobility group box family member 4 OS=Bos taurus OX=9913 GN=TOX4 PE=4 SV=1 CANONICAL=A0AAF6Z1E4-1" }, "locus": { "chromosome": "10", "start_pos": 25692914, "end_pos": 25678304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103533.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103533.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089919.1" } ] } }, { "isoform_ac": "A0AAA9TVF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVF0/entry", "sequence": { "sequence": "MELSRARVSVCQCLRVWTFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEEFRRQPPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVDMDPAPPSQTPSPPPVAAADPASPAPASTEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKFRINLQQQPPPLQVKIVPPPTLKMQTTLVPPPVESSPEQPVNNSPETHTVEETTPETICEMITDVVPEVESPSQMDVELVSGSPMTLSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK", "length": 611, "header": "tr|A0AAA9TVF0-1|A0AAF6Z1E4_BOVIN Computationally mapped isoform of TOX high mobility group box family member 4 OS=Bos taurus OX=9913 GN=TOX4 PE=4 SV=1 CANONICAL=A0AAF6Z1E4-1" }, "locus": { "chromosome": "10", "start_pos": 25692107, "end_pos": 25678304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130211.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130211.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100545.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100545.1" } ] } }, { "isoform_ac": "A0AAF6Z1E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4/entry", "sequence": { "sequence": "MSPAPKPRLGCFGSPPQLEDCRPQVTCVSDDDFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEEFRRQPPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVDMDPAPPSQTPSPPPVAAADPASPAPASTEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKFRINLQQQPPPLQVKIVPPPTLKMQTTLVPPPVESSPEQPVNNSPETHTVEETTPETICEMITDVVPEVESPSQMDVELVSGSPMTLSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK", "length": 649, "header": "tr|A0AAF6Z1E4-1|A0AAF6Z1E4_BOVIN Isoform 1 of TOX high mobility group box family member 4 OS=Bos taurus OX=9913 GN=TOX4 PE=4 SV=1 CANONICAL=A0AAF6Z1E4-1" }, "locus": { "chromosome": "10", "start_pos": 25693447, "end_pos": 25678304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020149.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020149.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020149.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020149.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 210, "start_aa": "Thr", "end_pos": 210, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr210", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" }, { "name": "PTW/PP1 phosphatase complex", "id": "GO:0072357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072357", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA polymerase II promoter clearance", "id": "GO:0001111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001111", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" }, { "name": "positive regulation of transcription elongation by RNA polymerase II", "id": "GO:0032968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 549, "end_pos": 551, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z1E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E4" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 253, "end_pos": 321, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 210 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 394, "end_pos": 396 }, { "start_pos": 549, "end_pos": 551 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0J2-1", "uniprot_ac": "A0AAF6Z0J2", "uniprot_id": "A0AAF6Z0J2_BOVIN", "mass": { "chemical_mass": 61697.0, "monoisotopic_mass": 61697.0 }, "refseq": {}, "gene_names": [ { "name": "OXA1L", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ] } ], "protein_names": [ { "name": "OXA1L mitochondrial inner membrane protein", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OXA1L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2", "locus": { "chromosome": "10", "start_pos": 22027169, "end_pos": 22067494, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014820", "url": "https://www.ensembl.org/id/ENSBTAG00000014820" } ] } } ], "crossref": [ { "id": "A0AAF6Z0J2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0J2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12428:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20981", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20981", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01157", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01157", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVASFYPQQQRLLLCPACHKQWDITSGTCFRFHNSGIQYGFLAQSVMMLQSSCQPGLQSSQGLPEAEESTSKLTHLLSLGLLQRATSSHGIDFPQGFLPRGCGSQCADANVRPLPGKMALALMCGRRQLLCLLRPQRQFHSVAGPCQWPRKPLTAGLGFPADRCLGHPRYVLLMAPGPRGLSTSAVSFGEAQVPAPPVIPATPPPTAVPEVASGEAADVIQAAAEQSFAELGLGSYTPVGLIQNLLEFMHVNLGLPWWGAIAACTVLARCLVFPLIVKGQREAAKIHNHLPEIQKFSARIREAKLTGNHTEFYRASSEMTFYQKKHDIKLFRPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTLSDPIYVLPLVVTATMWGVLELGAETGMQSSDLQWMRNFIRLMPLAVLPITIHFPTAVFMYWLSSNMFSLGQVACLRIPAVRTVLKIPQRVVHDPDKLAPREGFLKSFKQGWKNAEMAHQLQERERRMQNHLELAARGPLRQTFAHNPLLQHGKNDPPNTPNSSSSSSSSNKAKSKQPWRDTLG", "length": 558, "header": "tr|A0AAF6Z0J2-1|A0AAF6Z0J2_BOVIN Isoform 1 of OXA1L mitochondrial inner membrane protein OS=Bos taurus OX=9913 GN=OXA1L PE=3 SV=1 CANONICAL=A0AAF6Z0J2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R4/entry", "sequence": { "sequence": "MTKLKRLIMPSAAEPVEEHILLIEVYTATTTVENYKAVSTKGVIIYPVCACSVACDSDETPRTCSPPGSPVHGIFQGFLPRGCGSQCADANVRPLPGKMALALMCGRRQLLCLLRPQRQFHSVAGPCQWPRKPLTAGLGFPADRCLGHPRYVLLMAPGPRGLSTSAVSFGEAQVPAPPVIPATPPPTAVPEVASGEAADVIQAAAEQSFAELGLGSYTPVGLIQNLLEFMHVNLGLPWWGAIAACTVLARCLVFPLIVKGQREAAKIHNHLPEIQKFSARIREAKLTGNHTEFYRASSEMTFYQKKHDIKLFRPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTLSDPIYVLPLVVTATMWGVLELGAETGMQSSDLQWMRNFIRLMPLAVLPITIHFPTAVFMYWLSSNMFSLGQVACLRIPAVRTVLKIPQRVVHDPDKLAPREGFLKSFKQGWKNAEMAHQLQERERRMQNHLELAARGPLRQTFAHNPLLQHGKNDPPNTPNSSSSSSSSNKAKSKQPWRDTLG", "length": 539, "header": "tr|A0AAA9S6R4-1|A0AAF6Z0J2_BOVIN Computationally mapped isoform of OXA1L mitochondrial inner membrane protein OS=Bos taurus OX=9913 GN=OXA1L PE=3 SV=1 CANONICAL=A0AAF6Z0J2-1" }, "locus": { "chromosome": "10", "start_pos": 22055841, "end_pos": 22027651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109770.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109770.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078981.1" } ] } }, { "isoform_ac": "A0AAA9SLK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK2/entry", "sequence": { "sequence": "MSCSWPQAPAASVPLPSLLEKPRLIRQDDQHKGKEAGHPLHVLQAFQKTWSCSFGHIMRIYRKSDIVDIKGMRTVQKGMPHKCYHGKTGRIYNVTQHAVGIIINKQVKGKILAKRISVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKHQPAPPREAHFVRTNGKEPKLLEPIPYEFMA", "length": 187, "header": "tr|A0AAA9SLK2-1|A0AAF6Z0J2_BOVIN Computationally mapped isoform of OXA1L mitochondrial inner membrane protein OS=Bos taurus OX=9913 GN=OXA1L PE=3 SV=1 CANONICAL=A0AAF6Z0J2-1" }, "locus": { "chromosome": "10", "start_pos": 22041860, "end_pos": 22033235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121725.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121725.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087249.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087249.1" } ] } }, { "isoform_ac": "A0AAF6Z0J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2/entry", "sequence": { "sequence": "MVASFYPQQQRLLLCPACHKQWDITSGTCFRFHNSGIQYGFLAQSVMMLQSSCQPGLQSSQGLPEAEESTSKLTHLLSLGLLQRATSSHGIDFPQGFLPRGCGSQCADANVRPLPGKMALALMCGRRQLLCLLRPQRQFHSVAGPCQWPRKPLTAGLGFPADRCLGHPRYVLLMAPGPRGLSTSAVSFGEAQVPAPPVIPATPPPTAVPEVASGEAADVIQAAAEQSFAELGLGSYTPVGLIQNLLEFMHVNLGLPWWGAIAACTVLARCLVFPLIVKGQREAAKIHNHLPEIQKFSARIREAKLTGNHTEFYRASSEMTFYQKKHDIKLFRPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTLSDPIYVLPLVVTATMWGVLELGAETGMQSSDLQWMRNFIRLMPLAVLPITIHFPTAVFMYWLSSNMFSLGQVACLRIPAVRTVLKIPQRVVHDPDKLAPREGFLKSFKQGWKNAEMAHQLQERERRMQNHLELAARGPLRQTFAHNPLLQHGKNDPPNTPNSSSSSSSSNKAKSKQPWRDTLG", "length": 558, "header": "tr|A0AAF6Z0J2-1|A0AAF6Z0J2_BOVIN Isoform 1 of OXA1L mitochondrial inner membrane protein OS=Bos taurus OX=9913 GN=OXA1L PE=3 SV=1 CANONICAL=A0AAF6Z0J2-1" }, "locus": { "chromosome": "10", "start_pos": 22067490, "end_pos": 22027651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019736.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019736.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019736.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019736.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "mitochondrial ribosome binding", "id": "GO:0097177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097177", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "mitochondrial proton-transporting ATP synthase complex assembly", "id": "GO:0033615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane from matrix", "id": "GO:0032979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" }, { "name": "mitochondrial protein quality control", "id": "GO:0141164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141164", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z0J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J2" }, { "id": "PF02096", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02096" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Membrane insertase YidC/Oxa/ALB C-terminal", "eco_id": "ECO_0000259", "start_pos": 251, "end_pos": 449, "start_aa": "Val", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 }, { "start_pos": 536, "end_pos": 538 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZJP8-1", "uniprot_ac": "A0AAF6ZJP8", "uniprot_id": "A0AAF6ZJP8_BOVIN", "mass": { "chemical_mass": 59587.0, "monoisotopic_mass": 59587.0 }, "refseq": { "ac": "XP_005209827", "name": "gypsy retrotransposon integrase-like protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209827" }, "gene_names": [ { "name": "GIN1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8" } ] }, { "name": "GIN1", "type": "synonym", "evidence": [ { "id": "XP_005209827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209827" } ] } ], "protein_names": [ { "name": "Gypsy retrotransposon integrase-like protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8/entry#names_and_taxonomy" } ] }, { "name": "gypsy retrotransposon integrase-like protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209827" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8", "locus": { "chromosome": "7", "start_pos": 102111763, "end_pos": 102142033, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021471", "url": "https://www.ensembl.org/id/ENSBTAG00000021471" } ] } } ], "crossref": [ { "id": "A0AAF6ZJP8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZJP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "504972", "url": "https://www.ncbi.nlm.nih.gov/gene/504972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37984:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37984:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37984:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37984:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00665", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00665", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209827", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209827", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S926", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S926", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S926-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S926-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQDRLVVVSEEEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQINVELCELFGTKQIVISHASQTINPAESTPSTIKTFLSKHCVDYPNDWDDHLPAVSFAFNVTHLEPTKNTPYFQMFNRNPYMPESSDIREVDGDNTSMFAKILDAIKEADKIMENKTTSVGQMENNNCHELNKSKIIVKKKPKQQNPFHLKVGHEVLRQRKNWWKDGRFRSEWVGPCVIDYITENGGAVLRDSSGARLKRPIKMSHLKPYVRESGEQDSLHLLHGSVVADHDYVGMPELPVGAYQASILVEDAAIGVDDSELLTSSKDRELLEYRNAKISPLMEDHNALEKQTFSLLDSSNQVLEYLT", "length": 521, "header": "tr|A0AAF6ZJP8-1|A0AAF6ZJP8_BOVIN Isoform 1 of Gypsy retrotransposon integrase-like protein 1 OS=Bos taurus OX=9913 GN=GIN1 PE=4 SV=1 CANONICAL=A0AAF6ZJP8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S926-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S926/entry", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQDRLVVVSEEEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQIVSISYTVQW", "length": 223, "header": "tr|A0AAA9S926-1|A0AAF6ZJP8_BOVIN Computationally mapped isoform of Gypsy retrotransposon integrase-like protein 1 OS=Bos taurus OX=9913 GN=GIN1 PE=4 SV=1 CANONICAL=A0AAF6ZJP8-1" }, "locus": { "chromosome": "7", "start_pos": 102130807, "end_pos": 102112998, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078654.1" } ] } }, { "isoform_ac": "A0AAA9U2D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2D3/entry", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQDRLVVVSEEEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQINVELCELFGTKQIVISHASQTINPAESTPSTIKTFLSKHCVDYPNDWDDHLPAVSFAFNVTHLEPTKNTPYFQMFNRNPYMPESSDIREVDGDNTSMFAKILDAIKEADKIMENKTTSVGQMENNNCHELNKSKIIVKKKPKQQNPFHLKVGHEVLRQRKNWWKDGRFRSEWVGPCVIDYITENGGAVLRDSSGARLKRPIKMSHLKPYVRESGEQDSLHLLHGSVVADHDYVGMPELPVGAYQASILVEDAAIGVDDNHTSHLYISSSSSWIIGKAR", "length": 492, "header": "tr|A0AAA9U2D3-1|A0AAF6ZJP8_BOVIN Computationally mapped isoform of Gypsy retrotransposon integrase-like protein 1 OS=Bos taurus OX=9913 GN=GIN1 PE=4 SV=1 CANONICAL=A0AAF6ZJP8-1" }, "locus": { "chromosome": "7", "start_pos": 102130807, "end_pos": 102111764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101498.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101498.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103628.1" } ] } }, { "isoform_ac": "A0AAF6ZJP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8/entry", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQDRLVVVSEEEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQINVELCELFGTKQIVISHASQTINPAESTPSTIKTFLSKHCVDYPNDWDDHLPAVSFAFNVTHLEPTKNTPYFQMFNRNPYMPESSDIREVDGDNTSMFAKILDAIKEADKIMENKTTSVGQMENNNCHELNKSKIIVKKKPKQQNPFHLKVGHEVLRQRKNWWKDGRFRSEWVGPCVIDYITENGGAVLRDSSGARLKRPIKMSHLKPYVRESGEQDSLHLLHGSVVADHDYVGMPELPVGAYQASILVEDAAIGVDDSELLTSSKDRELLEYRNAKISPLMEDHNALEKQTFSLLDSSNQVLEYLT", "length": 521, "header": "tr|A0AAF6ZJP8-1|A0AAF6ZJP8_BOVIN Isoform 1 of Gypsy retrotransposon integrase-like protein 1 OS=Bos taurus OX=9913 GN=GIN1 PE=4 SV=1 CANONICAL=A0AAF6ZJP8-1" }, "locus": { "chromosome": "7", "start_pos": 102130807, "end_pos": 102112756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053077.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053077.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050552.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050552.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 242, "start_aa": "Thr", "end_pos": 242, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr242", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA integration", "id": "GO:0015074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015074", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJP8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZJP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJP8" }, { "id": "PS50994", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50994" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Integrase catalytic", "eco_id": "ECO_0000259", "start_pos": 135, "end_pos": 292, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 242 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 328, "end_pos": 330 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZJI4-1", "uniprot_ac": "A0AAF6ZJI4", "uniprot_id": "A0AAF6ZJI4_BOVIN", "mass": { "chemical_mass": 33705.0, "monoisotopic_mass": 33705.0 }, "refseq": {}, "gene_names": [ { "name": "BTBD19", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4" } ] } ], "protein_names": [ { "name": "BTB domain containing 19", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTBD19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4", "locus": { "chromosome": "3", "start_pos": 101200435, "end_pos": 101207043, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039529", "url": "https://www.ensembl.org/id/ENSBTAG00000039529" } ] } } ], "crossref": [ { "id": "A0AAF6ZJI4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZJI4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18294", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18294", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18494", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18494", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46965", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46965", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46965:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46965:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S991", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S991", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S991-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S991-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U150", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U150", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U150-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U150-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METPGLVVHGEAAPFSTALRSLVNNPLYSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVLEVLTAAVEYGLEELREGHLGTAHLRFCSQLCLEFVVKALDVELVCEALQVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 304, "header": "tr|A0AAF6ZJI4-1|A0AAF6ZJI4_BOVIN Isoform 1 of BTB domain containing 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=4 SV=1 CANONICAL=A0AAF6ZJI4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S991-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S991/entry", "sequence": { "sequence": "METPGLVVHGEAAPFSTALRSLVNNPLYSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVLEVLTAAVEYGLEELREVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 271, "header": "tr|A0AAA9S991-1|A0AAF6ZJI4_BOVIN Computationally mapped isoform of BTB domain containing 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=4 SV=1 CANONICAL=A0AAF6ZJI4-1" }, "locus": { "chromosome": "3", "start_pos": 101205587, "end_pos": 101201397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100380.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100380.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082640.1" } ] } }, { "isoform_ac": "A0AAA9TSH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSH2/entry", "sequence": { "sequence": "METPGLVVHGEAAPFSTALRSLVNNPLYSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 253, "header": "tr|A0AAA9TSH2-1|A0AAF6ZJI4_BOVIN Computationally mapped isoform of BTB domain containing 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=4 SV=1 CANONICAL=A0AAF6ZJI4-1" }, "locus": { "chromosome": "3", "start_pos": 101205587, "end_pos": 101201397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091094.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091094.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101329.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101329.1" } ] } }, { "isoform_ac": "A0AAA9U150-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U150/entry", "sequence": { "sequence": "RCSPNSPCPAGLTGSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVLEVLTAAVEYGLEELRELCLEFVVKALDVELVCEALQVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 277, "header": "tr|A0AAA9U150-1|A0AAF6ZJI4_BOVIN Computationally mapped isoform of BTB domain containing 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=4 SV=1 CANONICAL=A0AAF6ZJI4-1" }, "locus": { "chromosome": "3", "start_pos": 101207041, "end_pos": 101201397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106738.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106738.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103739.1" } ] } }, { "isoform_ac": "A0AAF6ZJI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4/entry", "sequence": { "sequence": "METPGLVVHGEAAPFSTALRSLVNNPLYSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVLEVLTAAVEYGLEELREGHLGTAHLRFCSQLCLEFVVKALDVELVCEALQVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 304, "header": "tr|A0AAF6ZJI4-1|A0AAF6ZJI4_BOVIN Isoform 1 of BTB domain containing 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=4 SV=1 CANONICAL=A0AAF6ZJI4-1" }, "locus": { "chromosome": "3", "start_pos": 101205587, "end_pos": 101201397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055916.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055916.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049973.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049973.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJI4" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 98, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGR1-1", "uniprot_ac": "A0AAF6ZGR1", "uniprot_id": "A0AAF6ZGR1_BOVIN", "mass": { "chemical_mass": 29451.0, "monoisotopic_mass": 29451.0 }, "refseq": {}, "gene_names": [ { "name": "NAPB", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ] } ], "protein_names": [ { "name": "NSF attachment protein beta", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA90#function" }, { "database": "UniProtKB", "id": "RU367013", "url": "https://www.uniprot.org/uniprotkb/RU367013#function" }, { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAPB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1", "locus": { "chromosome": "13", "start_pos": 42039083, "end_pos": 42076724, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032704", "url": "https://www.ensembl.org/id/ENSBTAG00000032704" } ] } } ], "crossref": [ { "id": "A0AAF6ZGR1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15832", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15832", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000744", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000744", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13768", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13768", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13768:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13768:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIFEQIGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK", "length": 259, "header": "tr|A0AAF6ZGR1-1|A0AAF6ZGR1_BOVIN Isoform 1 of NSF attachment protein beta OS=Bos taurus OX=9913 GN=NAPB PE=3 SV=1 CANONICAL=A0AAF6ZGR1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA90/entry", "sequence": { "sequence": "MHSVKPPSSTCSCRANTTQPPALWTPGTPTRRQTPKGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIFEQIGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK", "length": 220, "header": "tr|A0AAA9SA90-1|A0AAF6ZGR1_BOVIN Computationally mapped isoform of NSF attachment protein beta OS=Bos taurus OX=9913 GN=NAPB PE=3 SV=1 CANONICAL=A0AAF6ZGR1-1" }, "locus": { "chromosome": "13", "start_pos": 42054433, "end_pos": 42041508, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091969.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091969.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082246.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082246.1" } ] } }, { "isoform_ac": "A0AAF6ZGR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1/entry", "sequence": { "sequence": "MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIFEQIGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK", "length": 259, "header": "tr|A0AAF6ZGR1-1|A0AAF6ZGR1_BOVIN Isoform 1 of NSF attachment protein beta OS=Bos taurus OX=9913 GN=NAPB PE=3 SV=1 CANONICAL=A0AAF6ZGR1-1" }, "locus": { "chromosome": "13", "start_pos": 42076637, "end_pos": 42041508, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046446.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046446.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043745.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043745.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle priming", "id": "GO:0010807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010807", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" }, { "name": "synaptobrevin 2-SNAP-25-syntaxin-1a complex", "id": "GO:0070044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070044", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z5L1-1", "uniprot_ac": "A0AAF6Z5L1", "uniprot_id": "A0AAF6Z5L1_BOVIN", "mass": { "chemical_mass": 20131.0, "monoisotopic_mass": 20131.0 }, "refseq": {}, "gene_names": [ { "name": "NDUFAF3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM6#function" }, { "database": "UniProtKB", "id": "ARBA00004069", "url": "https://www.uniprot.org/uniprotkb/ARBA00004069#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFAF3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1", "locus": { "chromosome": "22", "start_pos": 50968278, "end_pos": 50969630, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018918", "url": "https://www.ensembl.org/id/ENSBTAG00000018918" } ] } } ], "crossref": [ { "id": "A0AAF6Z5L1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z5L1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05125", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05125", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21192:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21192:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04430", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04430", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAFVLRNLYRARPALRSPPSELPWAPRRGHRLTPADDELYQRTRISLLQRESPLAMYIDSYSSRGFVVNGNRVFGPCALLPQSVVQWNVQGLWENLRGLIFNLPPPHTEIVVVGTGDRTERLQPHVLRAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGTALTSQAQAAE", "length": 182, "header": "tr|A0AAF6Z5L1-1|A0AAF6Z5L1_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Bos taurus OX=9913 GN=NDUFAF3 PE=3 SV=1 CANONICAL=A0AAF6Z5L1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM6/entry", "sequence": { "sequence": "MAAAFVLRNLYRARPALRSPPSELPWAPRRGHRLTPADDELYQRTRISLLQRESPLAMYIDSYSSRGFVVNGNRVFGPCALLPQSVVQWNVGSYQDITEESFSLFWMLEPRIEIVVVGTGDRTERLQPHVLRAMRQRGIAVEPNACATFNFLCHEGRVTGAALIPPPGGTALTSQAQAAE", "length": 180, "header": "tr|A0AAA9SBM6-1|A0AAF6Z5L1_BOVIN Computationally mapped isoform of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Bos taurus OX=9913 GN=NDUFAF3 PE=3 SV=1 CANONICAL=A0AAF6Z5L1-1" }, "locus": { "chromosome": "22", "start_pos": 50969606, "end_pos": 50968646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108343.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108343.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081293.1" } ] } }, { "isoform_ac": "A0AAF6Z5L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1/entry", "sequence": { "sequence": "MAAAFVLRNLYRARPALRSPPSELPWAPRRGHRLTPADDELYQRTRISLLQRESPLAMYIDSYSSRGFVVNGNRVFGPCALLPQSVVQWNVQGLWENLRGLIFNLPPPHTEIVVVGTGDRTERLQPHVLRAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAALIPPPGGTALTSQAQAAE", "length": 182, "header": "tr|A0AAF6Z5L1-1|A0AAF6Z5L1_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Bos taurus OX=9913 GN=NDUFAF3 PE=3 SV=1 CANONICAL=A0AAF6Z5L1-1" }, "locus": { "chromosome": "22", "start_pos": 50969606, "end_pos": 50968646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025174.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025174.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025174.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025174.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5L1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCW1-1", "uniprot_ac": "A0AAF6ZCW1", "uniprot_id": "A0AAF6ZCW1_BOVIN", "mass": { "chemical_mass": 21525.0, "monoisotopic_mass": 21525.0 }, "refseq": {}, "gene_names": [ { "name": "HBA1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ] } ], "protein_names": [ { "name": "Hemoglobin, alpha 2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in oxygen transport from the lung to the various peripheral tissues.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDV9#function" }, { "database": "UniProtKB", "id": "ARBA00003705", "url": "https://www.uniprot.org/uniprotkb/ARBA00003705#function" }, { "database": "UniProtKB", "id": "A0AAA9SF20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF20#function" }, { "database": "UniProtKB", "id": "A0AAA9SI94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI94#function" }, { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HBA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZCW1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCW1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08927", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08927", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLSAADKGNVKAAWGKVGGHAAEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR", "length": 201, "header": "tr|A0AAF6ZCW1-1|A0AAF6ZCW1_BOVIN Isoform 1 of Hemoglobin, alpha 2 OS=Bos taurus OX=9913 GN=HBA1 PE=3 SV=1 CANONICAL=A0AAF6ZCW1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDV9/entry", "sequence": { "sequence": "MVLSAADKGNVKAAWGKVGGHAAEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR", "length": 172, "header": "tr|A0AAA9SDV9-1|A0AAF6ZCW1_BOVIN Computationally mapped isoform of Hemoglobin, alpha 2 OS=Bos taurus OX=9913 GN=HBA1 PE=3 SV=1 CANONICAL=A0AAF6ZCW1-1" }, "locus": { "chromosome": "25", "start_pos": 220219, "end_pos": 216535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126279.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126279.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084323.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084323.1" } ] } }, { "isoform_ac": "A0AAA9SF20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF20/entry", "sequence": { "sequence": "MRMVPWMTVSDPDSERTHHGAVCRRQGQCQGRLGQGWRPRCRVWRRGPGEDVPELPHHQDLLPPLRPEPRLRAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR", "length": 188, "header": "tr|A0AAA9SF20-1|A0AAF6ZCW1_BOVIN Computationally mapped isoform of Hemoglobin, alpha 2 OS=Bos taurus OX=9913 GN=HBA1 PE=3 SV=1 CANONICAL=A0AAF6ZCW1-1" }, "locus": { "chromosome": "25", "start_pos": 220219, "end_pos": 216003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084757.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084757.1" } ] } }, { "isoform_ac": "A0AAA9SI94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI94/entry", "sequence": { "sequence": "MSRPPGARLAATLQSMAQRPWREPTMVLSAADKGNVKAAWGKVGGHAAEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR", "length": 167, "header": "tr|A0AAA9SI94-1|A0AAF6ZCW1_BOVIN Computationally mapped isoform of Hemoglobin, alpha 2 OS=Bos taurus OX=9913 GN=HBA1 PE=3 SV=1 CANONICAL=A0AAF6ZCW1-1" }, "locus": { "chromosome": "25", "start_pos": 220219, "end_pos": 216563, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101064.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101064.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085056.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085056.1" } ] } }, { "isoform_ac": "A0AAF6ZCW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1/entry", "sequence": { "sequence": "MVLSAADKGNVKAAWGKVGGHAAEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR", "length": 201, "header": "tr|A0AAF6ZCW1-1|A0AAF6ZCW1_BOVIN Isoform 1 of Hemoglobin, alpha 2 OS=Bos taurus OX=9913 GN=HBA1 PE=3 SV=1 CANONICAL=A0AAF6ZCW1-1" }, "locus": { "chromosome": "25", "start_pos": 220219, "end_pos": 216535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037545.3", "url": "https://www.ensembl.org/id/ENSBTAT00000037545.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037374.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037374.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "pmid": "" }, { "name": "oxygen carrier activity", "id": "GO:0005344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "hemoglobin complex", "id": "GO:0005833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW1" }, { "id": "PS01033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Globin", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 201, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4B3-1", "uniprot_ac": "A0AAF6Z4B3", "uniprot_id": "A0AAF6Z4B3_BOVIN", "mass": { "chemical_mass": 68768.0, "monoisotopic_mass": 68768.0 }, "refseq": { "ac": "XP_002695926", "name": "cilia- and flagella-associated protein 52", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695926" }, "gene_names": [ { "name": "CFAP52", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ] }, { "name": "CFAP52", "type": "synonym", "evidence": [ { "id": "XP_002695926", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695926" } ] } ], "protein_names": [ { "name": "Cilia- and flagella-associated protein 52", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3/entry#names_and_taxonomy" } ] }, { "name": "cilia- and flagella-associated protein 52", "type": "synonym", "evidence": [ { "id": "XP_002695926", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695926" } ] } ], "function": [ { "annotation": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3#function" }, { "database": "UniProtKB", "id": "ARBA00046056", "url": "https://www.uniprot.org/uniprotkb/ARBA00046056#function" }, { "database": "UniProtKB", "id": "A0AAA9SGK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK7#function" }, { "database": "UniProtKB", "id": "A0AAA9TEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEX2#function" }, { "database": "UniProtKB", "id": "A0AAA9T190", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T190#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP52", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3", "locus": { "chromosome": "19", "start_pos": 28893275, "end_pos": 28867490, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017823", "url": "https://www.ensembl.org/id/ENSBTAG00000017823" } ] } } ], "crossref": [ { "id": "A0AAF6Z4B3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4B3", "database": "AlphaFoldDB", "categories": [] }, { "id": "505885", "url": "https://www.ncbi.nlm.nih.gov/gene/505885", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505885", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505885", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13720", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23409", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23409", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695926", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695926", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T190", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T190", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T190-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T190-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4B3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMETQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQNFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEALAFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTKLLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIRVWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPFPS", "length": 624, "header": "tr|A0AAF6Z4B3-1|A0AAF6Z4B3_BOVIN Isoform 1 of Cilia- and flagella-associated protein 52 OS=Bos taurus OX=9913 GN=CFAP52 PE=3 SV=1 CANONICAL=A0AAF6Z4B3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK7/entry", "sequence": { "sequence": "METQASPKDEVAEAVELELEAVIGFNDIILWDYKKRELMARLSLHKGKIEALAFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTKLLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIRVWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPFPS", "length": 555, "header": "tr|A0AAA9SGK7-1|A0AAF6Z4B3_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 52 OS=Bos taurus OX=9913 GN=CFAP52 PE=3 SV=1 CANONICAL=A0AAF6Z4B3-1" }, "locus": { "chromosome": "19", "start_pos": 28893073, "end_pos": 28867611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116487.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116487.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085314.1" } ] } }, { "isoform_ac": "A0AAA9T190-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T190/entry", "sequence": { "sequence": "MMETQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQNFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEALAFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTKLLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPINGTAELFATCAKKDIRVWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPFPS", "length": 567, "header": "tr|A0AAA9T190-1|A0AAF6Z4B3_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 52 OS=Bos taurus OX=9913 GN=CFAP52 PE=3 SV=1 CANONICAL=A0AAF6Z4B3-1" }, "locus": { "chromosome": "19", "start_pos": 28893073, "end_pos": 28867608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090547.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090547.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091459.1" } ] } }, { "isoform_ac": "A0AAA9TEX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEX2/entry", "sequence": { "sequence": "METQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQNFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEALAFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTKLLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIRVWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKVRVGTFLDGSATMPYNCLSVSGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPFPS", "length": 607, "header": "tr|A0AAA9TEX2-1|A0AAF6Z4B3_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 52 OS=Bos taurus OX=9913 GN=CFAP52 PE=3 SV=1 CANONICAL=A0AAF6Z4B3-1" }, "locus": { "chromosome": "19", "start_pos": 28893073, "end_pos": 28867611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114380.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114380.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095541.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095541.1" } ] } }, { "isoform_ac": "A0AAF6Z4B3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3/entry", "sequence": { "sequence": "MMETQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQNFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEALAFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTKLLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIRVWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPFPS", "length": 624, "header": "tr|A0AAF6Z4B3-1|A0AAF6Z4B3_BOVIN Isoform 1 of Cilia- and flagella-associated protein 52 OS=Bos taurus OX=9913 GN=CFAP52 PE=3 SV=1 CANONICAL=A0AAF6Z4B3-1" }, "locus": { "chromosome": "19", "start_pos": 28893073, "end_pos": 28867608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023697.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023697.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023697.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023697.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505885", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505885", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ], "pmid": "" }, { "name": "axonemal B tubule inner sheath", "id": "GO:0160112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160112", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ], "pmid": "" }, { "name": "establishment of left/right asymmetry", "id": "GO:0061966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061966", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z4B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4B3" }, { "id": "PF23409", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23409" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EML-like first beta-propeller", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 320, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 593, "end_pos": 595 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZG22-1", "uniprot_ac": "A0AAF6ZG22", "uniprot_id": "A0AAF6ZG22_BOVIN", "mass": { "chemical_mass": 88049.0, "monoisotopic_mass": 88049.0 }, "refseq": {}, "gene_names": [ { "name": "FASTKD3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZG22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" } ] } ], "protein_names": [ { "name": "FAST kinase domains 3", "type": "synonym", "evidence": [ { "id": "A0AAF6ZG22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FASTKD3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22", "locus": { "chromosome": "20", "start_pos": 65354970, "end_pos": 65345640, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009400", "url": "https://www.ensembl.org/id/ENSBTAG00000009400" } ] } } ], "crossref": [ { "id": "A0AAF6ZG22", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZG22", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZG22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZG22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALVTLRRNLYHLSDFRIHGALAALKTQQVNHVHKTVKEHLCPWFWSQHPGPIRVRFHHAHCKKFHSENGNDLHPVGEPGFSQVHNWDRFEHSVKNVDEQMFYRKLNSFTSSGEILRFVSTLETLPDTMMAGALHRICEVERKDGDQRLPKEILESSAFQALCDRFGRDPSDLSNAGLVTAFQALTLLCGDPQSHLLMNLEAECQHRLERGGLDVHSLCILGETLIKLHGPGCSTLDLIIYQLQGESLETFTPEDIVTVYRLLQASPEKADQQQRFLNKINHFSLSLVSNLSPKLMSQMLTALVVLDQTQALPLVIKLSKYVVRHIARFTSEELRKVLEALIYFGHSDRFFTETLEQHVASLCLTLDPELVSRVMEYCSRKLILSEPIFNAVAETFVCQAEKFSPSQTAKLIEPFGKLNYLPPNASALFRKLENMLLTRFNHFPPKTLLRLLHSCSLIESHPVNFMAKIFSPYFLQQLQGAESYLDRLSLAQLTQLFLTSILECPFYKGPKLLPKFQVKSFLTPCSSLETPMDFHLYKSVMIGLIDLLGARLYFSSKVLTPYCYTIDVEIKLDEDGFVLPFTIDEDVHKRVALCIDGPKRFCLNSKHLLGKEATKQRHLRLLGYQVVQIPYYEIEMLKSRLELVDYLQGKLFSQNSESRSFPVSQFFESSGQSIGVSASVLPMNIQGGFSLRMDWLDLLAVQGTLKSLLQHHNLKASILQCSALFIVQLSHPDMITGKTTALTVWTFVSKVMSLLFNTLFRFVIVFFQEASVF", "length": 773, "header": "tr|A0AAF6ZG22-1|A0AAF6ZG22_BOVIN Isoform 1 of FAST kinase domains 3 OS=Bos taurus OX=9913 GN=FASTKD3 PE=4 SV=1 CANONICAL=A0AAF6ZG22-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIH8/entry", "sequence": { "sequence": "MALVTLRRNLYHLSDFRIHGALAALKTQQVNHVHKTVKEHLCPWFWSQHPGPIRVRFHHAHCKKFHSENGNDLHPVGEPGFSQVHNWDRFEHSVKNVDEQMFYRKLNSFTSSGEILRFVSTLETLPDTMMAGALHRICEVERKDGDQRLPKEILESSAFQALCDRFGRDPSDLSNAGLVTAFQALTLLCGDPQSHLLMNLEAECQHRLERGGLDVHSLCILGETLIKLHGPGCSTLDLIIYQLQGESLETFTPEDIVTVYRLLQASPEKADQQQRFLNKINHFSLSLVSNLSPKLMSQMLTALVVLDQTQALPLVIKLSKYVVRHIARFTSEELRKVLEALIYFGHSDRFFTETLEQHVASLCLTLDPELVSRVMEYCSRKLILSEPIFNAVAETFVCQAEKFSPSQTAKLIEPFGKLNYLPPNASALFRKLENMLLTRFNHFPPKTLLRLLHSCSLIESHPVNFMAKIFSPYFLQQLQGAESYLDRLSLAQLTQLFLTSILECPFYKGPKLLPKFQVKSFLTPCSSLETPMDFHLYKSVMIGLIDLLGARLYFSSKVLTPYCYTIDVEIKLDEDGFVLPFTIDEDVHKRVALCIDGPKRFCLNSKHLLGKEATKQRHLRLLGYQVVQSHTPLHLSISDAPWSACGRAVCSERGGLPSGLSPSPRPLRWSPPLRVSQF", "length": 678, "header": "tr|A0AAA9SIH8-1|A0AAF6ZG22_BOVIN Computationally mapped isoform of FAST kinase domains 3 OS=Bos taurus OX=9913 GN=FASTKD3 PE=4 SV=1 CANONICAL=A0AAF6ZG22-1" }, "locus": { "chromosome": "20", "start_pos": 65353405, "end_pos": 65345677, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112981.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112981.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082353.1" } ] } }, { "isoform_ac": "A0AAF6ZG22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22/entry", "sequence": { "sequence": "MALVTLRRNLYHLSDFRIHGALAALKTQQVNHVHKTVKEHLCPWFWSQHPGPIRVRFHHAHCKKFHSENGNDLHPVGEPGFSQVHNWDRFEHSVKNVDEQMFYRKLNSFTSSGEILRFVSTLETLPDTMMAGALHRICEVERKDGDQRLPKEILESSAFQALCDRFGRDPSDLSNAGLVTAFQALTLLCGDPQSHLLMNLEAECQHRLERGGLDVHSLCILGETLIKLHGPGCSTLDLIIYQLQGESLETFTPEDIVTVYRLLQASPEKADQQQRFLNKINHFSLSLVSNLSPKLMSQMLTALVVLDQTQALPLVIKLSKYVVRHIARFTSEELRKVLEALIYFGHSDRFFTETLEQHVASLCLTLDPELVSRVMEYCSRKLILSEPIFNAVAETFVCQAEKFSPSQTAKLIEPFGKLNYLPPNASALFRKLENMLLTRFNHFPPKTLLRLLHSCSLIESHPVNFMAKIFSPYFLQQLQGAESYLDRLSLAQLTQLFLTSILECPFYKGPKLLPKFQVKSFLTPCSSLETPMDFHLYKSVMIGLIDLLGARLYFSSKVLTPYCYTIDVEIKLDEDGFVLPFTIDEDVHKRVALCIDGPKRFCLNSKHLLGKEATKQRHLRLLGYQVVQIPYYEIEMLKSRLELVDYLQGKLFSQNSESRSFPVSQFFESSGQSIGVSASVLPMNIQGGFSLRMDWLDLLAVQGTLKSLLQHHNLKASILQCSALFIVQLSHPDMITGKTTALTVWTFVSKVMSLLFNTLFRFVIVFFQEASVF", "length": 773, "header": "tr|A0AAF6ZG22-1|A0AAF6ZG22_BOVIN Isoform 1 of FAST kinase domains 3 OS=Bos taurus OX=9913 GN=FASTKD3 PE=4 SV=1 CANONICAL=A0AAF6ZG22-1" }, "locus": { "chromosome": "20", "start_pos": 65354514, "end_pos": 65345677, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046066.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046066.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043394.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043394.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of mitochondrial mRNA stability", "id": "GO:0044528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044528", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial translation", "id": "GO:0070131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070131", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZG22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG22" }, { "id": "PS51286", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RAP", "eco_id": "ECO_0000259", "start_pos": 591, "end_pos": 649, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 290, "end_pos": 292 }, { "start_pos": 424, "end_pos": 426 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z126-1", "uniprot_ac": "A0AAF6Z126", "uniprot_id": "A0AAF6Z126_BOVIN", "mass": { "chemical_mass": 41361.0, "monoisotopic_mass": 41361.0 }, "refseq": { "ac": "XP_024843770", "name": "PHD finger protein 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843770" }, "gene_names": [ { "name": "PHF6", "type": "recommended", "evidence": [ { "id": "A0AAF6Z126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ] }, { "name": "PHF6", "type": "synonym", "evidence": [ { "id": "XP_024843770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843770" } ] } ], "protein_names": [ { "name": "PHD finger protein 6", "type": "recommended", "evidence": [ { "id": "A0AAF6Z126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126/entry#names_and_taxonomy" } ] }, { "name": "PHD finger protein 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024843770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843770" } ] } ], "function": [ { "annotation": "Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126#function" }, { "database": "UniProtKB", "id": "ARBA00057892", "url": "https://www.uniprot.org/uniprotkb/ARBA00057892#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126", "locus": { "chromosome": "X", "start_pos": 18153205, "end_pos": 18106742, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015196", "url": "https://www.ensembl.org/id/ENSBTAG00000015196" } ] } } ], "crossref": [ { "id": "A0AAF6Z126", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z126", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15710", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15710", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15711", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15711", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518186", "url": "https://www.ncbi.nlm.nih.gov/gene/518186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12420", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12420", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12420:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12420:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12420:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12420:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024843770", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843770", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z126-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEAADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENQARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGKVEIDQQQLTQQQLNGN", "length": 366, "header": "tr|A0AAF6Z126-1|A0AAF6Z126_BOVIN Isoform 1 of PHD finger protein 6 OS=Bos taurus OX=9913 GN=PHF6 PE=4 SV=1 CANONICAL=A0AAF6Z126-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ58/entry", "sequence": { "sequence": "MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENQARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGKVEIDQQQLTQQQLNGN", "length": 331, "header": "tr|A0AAA9SJ58-1|A0AAF6Z126_BOVIN Computationally mapped isoform of PHD finger protein 6 OS=Bos taurus OX=9913 GN=PHF6 PE=4 SV=1 CANONICAL=A0AAF6Z126-1" }, "locus": { "chromosome": "X", "start_pos": 18152201, "end_pos": 18110948, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124965.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124965.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083946.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083946.1" } ] } }, { "isoform_ac": "A0AAA9TX65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX65/entry", "sequence": { "sequence": "MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEGTSSATFFQEEI", "length": 151, "header": "tr|A0AAA9TX65-1|A0AAF6Z126_BOVIN Computationally mapped isoform of PHD finger protein 6 OS=Bos taurus OX=9913 GN=PHF6 PE=4 SV=1 CANONICAL=A0AAF6Z126-1" }, "locus": { "chromosome": "X", "start_pos": 18125572, "end_pos": 18110948, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101951.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101951.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101800.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101800.1" } ] } }, { "isoform_ac": "A0AAF6Z126-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126/entry", "sequence": { "sequence": "MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEAADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENQARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGKVEIDQQQLTQQQLNGN", "length": 366, "header": "tr|A0AAF6Z126-1|A0AAF6Z126_BOVIN Isoform 1 of PHD finger protein 6 OS=Bos taurus OX=9913 GN=PHF6 PE=4 SV=1 CANONICAL=A0AAF6Z126-1" }, "locus": { "chromosome": "X", "start_pos": 18152201, "end_pos": 18110948, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020218.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020218.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020218.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020218.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "ribonucleoprotein complex binding", "id": "GO:0043021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "scaffold protein binding", "id": "GO:0097110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z126", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z126" }, { "id": "PS51805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 132, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8F0-1", "uniprot_ac": "A0AAF6Z8F0", "uniprot_id": "A0AAF6Z8F0_BOVIN", "mass": { "chemical_mass": 50855.0, "monoisotopic_mass": 50855.0 }, "refseq": {}, "gene_names": [ { "name": "CASP4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" } ] } ], "protein_names": [ { "name": "Caspase 4, apoptosis-related cysteine peptidase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CASP4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z8F0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8F0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020884", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020884", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00032", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00032", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08325", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08325", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "338039", "url": "https://www.ncbi.nlm.nih.gov/gene/338039", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5A8", "url": "https://www.orthodb.org/?gene=F1N5A8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47901", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47901", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47901:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47901:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00656", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00656", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5A8", "url": "https://www.uniprot.org/uniprotkb/F1N5A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5A8-1", "url": "https://www.uniprot.org/uniprotkb/F1N5A8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNKHFFPKGWEIHLLTTGDFPTVNPEVPNKNFSICGYKSQPPVLRKCPVTFIFETVLLQGSRKILSLLSMAEDKHNKNPLKMLESLGKELISGLLDDFVEKNVLKLEEEEKKKIYDAKLQDKARVLVDSIRQKNQEAGQVFVQTFLNIDKNSTSIKAPEETVAGPDESVGSAATLKLCPHEEFLKLCKERAGEIYPIKERKDRTRLALIICNTEFDHMPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARDMESVLWKFAAREEHKSSDSTFLVFMSHGILDGICGTMHSEEEPDVLPYDTIFRTFNNRNCLSLKDKPKVIIVQACRGANRGELWVSDSPPALADSFSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDIKKGSLFITRLITCFQKYAWCCHLEEVFRKVQQSFEKPNVKAQMPTVERLSMTRYFYLFPGN", "length": 446, "header": "tr|A0AAF6Z8F0-1|A0AAF6Z8F0_BOVIN Isoform 1 of Caspase 4, apoptosis-related cysteine peptidase OS=Bos taurus OX=9913 GN=CASP4 PE=3 SV=1 CANONICAL=A0AAF6Z8F0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN6/entry", "sequence": { "sequence": "MNKHFFPKGWEIHLLTTGDFPTVNPEVPNKNFSICGYKSQPPVLRKCPVTFIFETVLLQGSRKILSLLSMAAPEETVAGPDESVGSAATLKLCPHEEFLKLCKERAGEIYPIKERKDRTRLALIICNTEFDHMPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARDMESVLWKFAAREEHKSSDSTFLVFMSHGILDGICGTMHSEEEPDVLPYDTIFRTFNNRNCLSLKDKPKVIIVQACRGANRGELWVSDSPPALADSFSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDIKKGSLFITRLITCFQKYAWCCHLEEVFRKVQQSFEKPNVKAQMPTVERLSMTRYFYLFPGN", "length": 361, "header": "tr|A0AAA9SMN6-1|A0AAF6Z8F0_BOVIN Computationally mapped isoform of Caspase 4, apoptosis-related cysteine peptidase OS=Bos taurus OX=9913 GN=CASP4 PE=3 SV=1 CANONICAL=A0AAF6Z8F0-1" }, "locus": { "chromosome": "15", "start_pos": 3265513, "end_pos": 3250048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116406.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116406.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087618.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087618.1" } ] } }, { "isoform_ac": "A0AAF6Z8F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0/entry", "sequence": { "sequence": "MNKHFFPKGWEIHLLTTGDFPTVNPEVPNKNFSICGYKSQPPVLRKCPVTFIFETVLLQGSRKILSLLSMAEDKHNKNPLKMLESLGKELISGLLDDFVEKNVLKLEEEEKKKIYDAKLQDKARVLVDSIRQKNQEAGQVFVQTFLNIDKNSTSIKAPEETVAGPDESVGSAATLKLCPHEEFLKLCKERAGEIYPIKERKDRTRLALIICNTEFDHMPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARDMESVLWKFAAREEHKSSDSTFLVFMSHGILDGICGTMHSEEEPDVLPYDTIFRTFNNRNCLSLKDKPKVIIVQACRGANRGELWVSDSPPALADSFSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDIKKGSLFITRLITCFQKYAWCCHLEEVFRKVQQSFEKPNVKAQMPTVERLSMTRYFYLFPGN", "length": 446, "header": "tr|A0AAF6Z8F0-1|A0AAF6Z8F0_BOVIN Isoform 1 of Caspase 4, apoptosis-related cysteine peptidase OS=Bos taurus OX=9913 GN=CASP4 PE=3 SV=1 CANONICAL=A0AAF6Z8F0-1" }, "locus": { "chromosome": "15", "start_pos": 3265513, "end_pos": 3250048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027820.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027820.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027820.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027820.4" } ] } }, { "isoform_ac": "F1N5A8-1", "url": "https://www.uniprot.org/uniprotkb/F1N5A8/entry", "sequence": { "sequence": "LTEDKHNKNPLKMLESLGKELISGLLDDFVEKNVLKLEEEEKKKIYDAKLQDKARVLVDSIRQKNQEIYPIKERKDRTRLALIICNTEFDHMPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARDMESVLWKFAAREEHKSSDSTFLVFMSHGILDGICGTMHSEEEPDVLPYDTIFRTFNNRNCLSLKDKPKVIIVQACRGANRGELWVSDSPPALADSFSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDIKKGSLFITRLITCFQKYAWCCHLEEVFRKVQQSFEKPNVKAQMPTVERLSMTRYFYLFPGN", "length": 320, "header": "tr|F1N5A8-1|A0AAF6Z8F0_BOVIN Computationally mapped isoform of Caspase 4, apoptosis-related cysteine peptidase OS=Bos taurus OX=9913 GN=CASP4 PE=3 SV=1 CANONICAL=A0AAF6Z8F0-1" }, "locus": { "chromosome": "15", "start_pos": 3265513, "end_pos": 3254034, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052006.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052006.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052549.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052549.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z8F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" }, { "id": "PS50209", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50209" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CARD", "eco_id": "ECO_0000259", "start_pos": 67, "end_pos": 160, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z8F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" }, { "id": "PS50207", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50207" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Caspase family p10", "eco_id": "ECO_0000259", "start_pos": 359, "end_pos": 444, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z8F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8F0" }, { "id": "PS50208", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50208" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Caspase family p20", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 331, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 379, "end_pos": 381 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGR8-1", "uniprot_ac": "A0AAF6ZGR8", "uniprot_id": "A0AAF6ZGR8_BOVIN", "mass": { "chemical_mass": 43911.0, "monoisotopic_mass": 43911.0 }, "refseq": {}, "gene_names": [ { "name": "CDK10", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ] } ], "protein_names": [ { "name": "Cyclin dependent kinase 10", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDK10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8", "locus": { "chromosome": "18", "start_pos": 14579302, "end_pos": 14568450, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033333", "url": "https://www.ensembl.org/id/ENSBTAG00000033333" } ] } } ], "crossref": [ { "id": "A0AAF6ZGR8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGR8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07845", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07845", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24056", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24056", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24056:SF508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24056:SF508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2Z3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMCSAPSLRPSSWGTGPGGARELRGDPALLCRAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRP", "length": 390, "header": "tr|A0AAF6ZGR8-1|A0AAF6ZGR8_BOVIN Isoform 1 of Cyclin dependent kinase 10 OS=Bos taurus OX=9913 GN=CDK10 PE=3 SV=1 CANONICAL=A0AAF6ZGR8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB8/entry", "sequence": { "sequence": "MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVWVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRP", "length": 337, "header": "tr|A0AAA9SRB8-1|A0AAF6ZGR8_BOVIN Computationally mapped isoform of Cyclin dependent kinase 10 OS=Bos taurus OX=9913 GN=CDK10 PE=3 SV=1 CANONICAL=A0AAF6ZGR8-1" }, "locus": { "chromosome": "18", "start_pos": 14575081, "end_pos": 14568489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102532.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102532.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088884.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088884.1" } ] } }, { "isoform_ac": "A0AAA9SS41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS41/entry", "sequence": { "sequence": "MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQTSWPSAGQVHRAAGAPGPPVPAPEFHHPQLLNGLALPVLLLLKSTNRTRCVGKRSECCCSADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRP", "length": 381, "header": "tr|A0AAA9SS41-1|A0AAF6ZGR8_BOVIN Computationally mapped isoform of Cyclin dependent kinase 10 OS=Bos taurus OX=9913 GN=CDK10 PE=3 SV=1 CANONICAL=A0AAF6ZGR8-1" }, "locus": { "chromosome": "18", "start_pos": 14575081, "end_pos": 14568489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090672.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090672.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085831.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085831.1" } ] } }, { "isoform_ac": "A0AAA9TQY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY4/entry", "sequence": { "sequence": "MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHSTNRTRCVGKRSECCCSADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPGTGARRPTLAARRHGPGRAARGPGRRAPTGRR", "length": 358, "header": "tr|A0AAA9TQY4-1|A0AAF6ZGR8_BOVIN Computationally mapped isoform of Cyclin dependent kinase 10 OS=Bos taurus OX=9913 GN=CDK10 PE=3 SV=1 CANONICAL=A0AAF6ZGR8-1" }, "locus": { "chromosome": "18", "start_pos": 14578794, "end_pos": 14568489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097476.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097476.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099738.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099738.1" } ] } }, { "isoform_ac": "A0AAF6ZGR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8/entry", "sequence": { "sequence": "MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMCSAPSLRPSSWGTGPGGARELRGDPALLCRAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRP", "length": 390, "header": "tr|A0AAF6ZGR8-1|A0AAF6ZGR8_BOVIN Isoform 1 of Cyclin dependent kinase 10 OS=Bos taurus OX=9913 GN=CDK10 PE=3 SV=1 CANONICAL=A0AAF6ZGR8-1" }, "locus": { "chromosome": "18", "start_pos": 14575081, "end_pos": 14568489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047400.6", "url": "https://www.ensembl.org/id/ENSBTAT00000047400.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044609.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044609.4" } ] } }, { "isoform_ac": "A0ABI0P2Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Z3/entry", "sequence": { "sequence": "RARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRP", "length": 309, "header": "tr|A0ABI0P2Z3-1|A0ABI0P2Z3_BOVIN Computationally mapped isoform of Cyclin dependent kinase 10 OS=Bos taurus OX=9913 GN=CDK10 PE=3 SV=1 CANONICAL=A0AAF6ZGR8-1" }, "locus": { "chromosome": "18", "start_pos": 14575081, "end_pos": 14571364, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105007.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0004693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of mitotic cell cycle", "id": "GO:0007346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007346", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" }, { "name": "negative regulation of cilium assembly", "id": "GO:1902018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902018", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" }, { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZGR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR8" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 350, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z650-1", "uniprot_ac": "A0AAF6Z650", "uniprot_id": "A0AAF6Z650_BOVIN", "mass": { "chemical_mass": 39704.0, "monoisotopic_mass": 39704.0 }, "refseq": {}, "gene_names": [ { "name": "METTL9", "type": "recommended", "evidence": [ { "id": "A0AAF6Z650", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650" } ] } ], "protein_names": [ { "name": "Methyltransferase 9, His-X-His N1(pi)-histidine", "type": "synonym", "evidence": [ { "id": "A0AAF6Z650", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z650", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650", "locus": { "chromosome": "25", "start_pos": 20146094, "end_pos": 20097168, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018868", "url": "https://www.ensembl.org/id/ENSBTAG00000018868" } ] } } ], "crossref": [ { "id": "A0AAF6Z650", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z650", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787067", "url": "https://www.ncbi.nlm.nih.gov/gene/787067", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12890", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12890", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12890:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12890:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05219", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05219", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z650", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z650-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLAGWLCLSLASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRTCYAKSLQSCPTLCDPIDGSPPGPSSLGFSRVLGINEWQKTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENVGGKWDKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV", "length": 349, "header": "tr|A0AAF6Z650-1|A0AAF6Z650_BOVIN Isoform 1 of Methyltransferase 9, His-X-His N1(pi)-histidine OS=Bos taurus OX=9913 GN=METTL9 PE=4 SV=2 CANONICAL=A0AAF6Z650-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE5/entry", "sequence": { "sequence": "MRLLAGWLCLSLASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQKTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENGGKWDKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV", "length": 317, "header": "tr|A0AAA9STE5-1|A0AAF6Z650_BOVIN Computationally mapped isoform of Methyltransferase 9, His-X-His N1(pi)-histidine OS=Bos taurus OX=9913 GN=METTL9 PE=4 SV=1 CANONICAL=A0AAF6Z650-1" }, "locus": { "chromosome": "25", "start_pos": 20145090, "end_pos": 20099397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090635.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090635.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089695.1" } ] } }, { "isoform_ac": "A0AAF6Z650-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650/entry", "sequence": { "sequence": "MRLLAGWLCLSLASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRTCYAKSLQSCPTLCDPIDGSPPGPSSLGFSRVLGINEWQKTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENVGGKWDKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV", "length": 349, "header": "tr|A0AAF6Z650-1|A0AAF6Z650_BOVIN Isoform 1 of Methyltransferase 9, His-X-His N1(pi)-histidine OS=Bos taurus OX=9913 GN=METTL9 PE=4 SV=2 CANONICAL=A0AAF6Z650-1" }, "locus": { "chromosome": "25", "start_pos": 20145090, "end_pos": 20099397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025118.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025118.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025118.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025118.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-L-histidine N-pros-methyltransferase activity", "id": "GO:0106370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106370", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z650", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z650" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 35, "end_pos": 37 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZHI0-1", "uniprot_ac": "A0AAF6ZHI0", "uniprot_id": "A0AAF6ZHI0_BOVIN", "mass": { "chemical_mass": 22611.0, "monoisotopic_mass": 22611.0 }, "refseq": {}, "gene_names": [ { "name": "ASIP", "type": "recommended", "evidence": [ { "id": "A0AAF6ZHI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0" } ] } ], "protein_names": [ { "name": "Agouti-signaling protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZHI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0/entry#names_and_taxonomy" } ] }, { "name": "Agouti switch protein", "type": "synonym", "evidence": [ { "id": "A0AAF6ZHI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASIP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0", "locus": { "chromosome": "13", "start_pos": 63668123, "end_pos": 63638921, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034077", "url": "https://www.ensembl.org/id/ENSBTAG00000034077" } ] } } ], "crossref": [ { "id": "A0AAF6ZHI0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZHI0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16551:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16551:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMNGHDILNKEGRSQDGGGVGRGEHFLPHKFIKRAFKRRVNSTKQLLNAGRGHQAPRKATQLFERRPPGMDVSRLLLATLLVCLCFLTAYSHLAPEEKPRDERNLKNNSSMNLLDFPSVSIVALNKKSKKISRNEAEKKKRPSKRKAPMKNVARTRPPPPTPCVATRDSCKPPAPACCDPCAFCQCRFFRSACSCRVLNPTC", "length": 202, "header": "tr|A0AAF6ZHI0-1|A0AAF6ZHI0_BOVIN Isoform 1 of Agouti-signaling protein OS=Bos taurus OX=9913 GN=ASIP PE=4 SV=1 CANONICAL=A0AAF6ZHI0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STS3/entry", "sequence": { "sequence": "MMNGHDILNKEGRSQDGGGVGRGEHFLPHKFIKRAFKRRVNSTKQLLNAGRGHQAPRKATQLFERRPPGMDVSRLLLATLLVCLCFLTAYSHLAPEEKPRDERNLKNNSSMNLLDFPSVSIVALNKKSKKISRNEAEKKKRPSKDFPGGSMVKNPPASAEDMGWILGSERPPHGSEQLGLCAPTIEPVL", "length": 189, "header": "tr|A0AAA9STS3-1|A0AAF6ZHI0_BOVIN Computationally mapped isoform of Agouti-signaling protein OS=Bos taurus OX=9913 GN=ASIP PE=4 SV=1 CANONICAL=A0AAF6ZHI0-1" }, "locus": { "chromosome": "13", "start_pos": 63664903, "end_pos": 63639054, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124403.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124403.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087385.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087385.1" } ] } }, { "isoform_ac": "A0AAF6ZHI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0/entry", "sequence": { "sequence": "MMNGHDILNKEGRSQDGGGVGRGEHFLPHKFIKRAFKRRVNSTKQLLNAGRGHQAPRKATQLFERRPPGMDVSRLLLATLLVCLCFLTAYSHLAPEEKPRDERNLKNNSSMNLLDFPSVSIVALNKKSKKISRNEAEKKKRPSKRKAPMKNVARTRPPPPTPCVATRDSCKPPAPACCDPCAFCQCRFFRSACSCRVLNPTC", "length": 202, "header": "tr|A0AAF6ZHI0-1|A0AAF6ZHI0_BOVIN Isoform 1 of Agouti-signaling protein OS=Bos taurus OX=9913 GN=ASIP PE=4 SV=1 CANONICAL=A0AAF6ZHI0-1" }, "locus": { "chromosome": "13", "start_pos": 63667943, "end_pos": 63639054, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048322.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048322.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045382.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045382.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 161, "start_aa": "Thr", "end_pos": 161, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr161", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "hormone-mediated signaling pathway", "id": "GO:0009755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009755", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHI0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZHI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHI0" }, { "id": "PS51150", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51150" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Agouti", "eco_id": "ECO_0000259", "start_pos": 163, "end_pos": 202, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 161 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 108, "end_pos": 110 }, { "start_pos": 41, "end_pos": 43 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0C8-1", "uniprot_ac": "A0AAF6Z0C8", "uniprot_id": "A0AAF6Z0C8_BOVIN", "mass": { "chemical_mass": 46249.0, "monoisotopic_mass": 46249.0 }, "refseq": {}, "gene_names": [ { "name": "PTCD2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8" } ] } ], "protein_names": [ { "name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TXS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXS1#function" }, { "database": "UniProtKB", "id": "ARBA00057704", "url": "https://www.uniprot.org/uniprotkb/ARBA00057704#function" }, { "database": "UniProtKB", "id": "A0AAF6Z0C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTCD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8", "locus": { "chromosome": "20", "start_pos": 9254758, "end_pos": 9286706, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014675", "url": "https://www.ensembl.org/id/ENSBTAG00000014675" } ] } } ], "crossref": [ { "id": "A0AAF6Z0C8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0C8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14700", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14700", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14700:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14700:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SV15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKGMLVRGRRAEEGAESRCTLRPLPCSHRWCGPEQHGGYLAAPEASPSAACAAKFGVSLAKRYLLTDSIVKLKEFQRKKVAVACNLPGTKETYLRNLEEKLTQNKLILKEELRTLLHLCTSRDDVELAKHVIYRYHAENRNITLGEYKFGPLFVRLCYELDLEDSAVELIKDQHLQGFFSDSTSFNILMDMLFIKGKYRSALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 406, "header": "tr|A0AAF6Z0C8-1|A0AAF6Z0C8_BOVIN Isoform 1 of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=3 SV=1 CANONICAL=A0AAF6Z0C8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV15/entry", "sequence": { "sequence": "AARNSMAATLRPPKQVLLLHALRSLVYHWVGGSGSTCCLCPLGAKRYLLTDSIVKLKEFQRKKVAVACNLPGTKGALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 280, "header": "tr|A0AAA9SV15-1|A0AAF6Z0C8_BOVIN Computationally mapped isoform of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=3 SV=1 CANONICAL=A0AAF6Z0C8-1" }, "locus": { "chromosome": "20", "start_pos": 9286533, "end_pos": 9255545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090894.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090894.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088018.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088018.1" } ] } }, { "isoform_ac": "A0AAA9T4S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S9/entry", "sequence": { "sequence": "MAATLRPPKQVLLLHALRSLVYHWVGGSGSTCCLCPLGAKRYLLTDSIVKLKEFQRKKVAVACNLPGTKETYLRNLEEKLTQNKLILKEELRTLLHLCTSRDDVELAKHVIYRYHAENRNITLGEYKFGPLFVRLCYELDLEDSAVELIKDQHLQGFFSDSTSFNILMDMLFIKGKYRSALEVLIQMKNQDLKFNKDTYVLAFAICYKLNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 346, "header": "tr|A0AAA9T4S9-1|A0AAF6Z0C8_BOVIN Computationally mapped isoform of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=3 SV=1 CANONICAL=A0AAF6Z0C8-1" }, "locus": { "chromosome": "20", "start_pos": 9286518, "end_pos": 9255545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093807.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093807.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091714.1" } ] } }, { "isoform_ac": "A0AAA9TCR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR3/entry", "sequence": { "sequence": "TWSWLNMSFTGALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 216, "header": "tr|A0AAA9TCR3-1|A0AAF6Z0C8_BOVIN Computationally mapped isoform of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=3 SV=1 CANONICAL=A0AAF6Z0C8-1" }, "locus": { "chromosome": "20", "start_pos": 9281470, "end_pos": 9255545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118031.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118031.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095849.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095849.1" } ] } }, { "isoform_ac": "A0AAA9TXS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXS1/entry", "sequence": { "sequence": "MAATLRPPKQVLLLHALRSLVYHWVGGSGSTCCLCPLGETYLRNLEEKLTQNKLILKEELRTLLHLCTSRDDVELAKHVIYRYHAENRNITLGEYKFGPLFVRLCYELDLEDSAVELIKDQHLQGFFSDSTSFNILMDMLFIKGKYRSALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 353, "header": "tr|A0AAA9TXS1-1|A0AAF6Z0C8_BOVIN Computationally mapped isoform of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=3 SV=1 CANONICAL=A0AAF6Z0C8-1" }, "locus": { "chromosome": "20", "start_pos": 9286518, "end_pos": 9255545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121345.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121345.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103456.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103456.1" } ] } }, { "isoform_ac": "A0AAF6Z0C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8/entry", "sequence": { "sequence": "MPKGMLVRGRRAEEGAESRCTLRPLPCSHRWCGPEQHGGYLAAPEASPSAACAAKFGVSLAKRYLLTDSIVKLKEFQRKKVAVACNLPGTKETYLRNLEEKLTQNKLILKEELRTLLHLCTSRDDVELAKHVIYRYHAENRNITLGEYKFGPLFVRLCYELDLEDSAVELIKDQHLQGFFSDSTSFNILMDMLFIKGKYRSALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 406, "header": "tr|A0AAF6Z0C8-1|A0AAF6Z0C8_BOVIN Isoform 1 of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=3 SV=1 CANONICAL=A0AAF6Z0C8-1" }, "locus": { "chromosome": "20", "start_pos": 9286627, "end_pos": 9255545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019535.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019535.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019535.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019535.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of mRNA processing", "id": "GO:0050684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050684", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0C8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 318, "end_pos": 320 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1J5-1", "uniprot_ac": "A0AAF6Z1J5", "uniprot_id": "A0AAF6Z1J5_BOVIN", "mass": { "chemical_mass": 84406.0, "monoisotopic_mass": 84406.0 }, "refseq": { "ac": "XP_005212604", "name": "translation initiation factor IF-2, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212604" }, "gene_names": [ { "name": "MTIF2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ] }, { "name": "MTIF2", "type": "synonym", "evidence": [ { "id": "XP_005212604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212604" } ] } ], "protein_names": [ { "name": "Translation initiation factor IF-2, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5/entry#names_and_taxonomy" } ] }, { "name": "translation initiation factor IF-2, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212604" } ] } ], "function": [ { "annotation": "One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5#function" }, { "database": "UniProtKB", "id": "ARBA00025162", "url": "https://www.uniprot.org/uniprotkb/ARBA00025162#function" }, { "database": "UniProtKB", "id": "A0AAA9SV99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV99#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTIF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5", "locus": { "chromosome": "11", "start_pos": 37973410, "end_pos": 37996291, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015481", "url": "https://www.ensembl.org/id/ENSBTAG00000015481" } ] } } ], "crossref": [ { "id": "A0AAF6Z1J5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1J5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01887", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01887", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03692", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03692", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03702", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03702", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281923", "url": "https://www.ncbi.nlm.nih.gov/gene/281923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053905", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053905", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43381:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43381:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11987", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11987", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212604", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212604", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SV99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1J5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDCPAGPEGDLRPLQNPGVLGPRRNMNRKILKLENLLRFHTICRQLHSLCQRRMLAQWRHMFSSAYAVHTAQLYTRPWQTDALLRAALSQRRLLVTKKEKRSQKSPLPSTKSKKEVEVWLGMTVEELARAMEKDIDCVYESLMNTAIDIDSLETHSRLDEVWIKEVIKKSGMKLKWSKLKQDKVRENKDAVKRPQADPALLIPRSPVVTIMGHVDHGKTTLLDKLRKTQVAAMEAGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVESIQHAKDAHVPIVLAINKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVHVSALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFTDKGRGPVTTAIIQRGTLRKGSILVAGKSWAKVRLMFDENGRAVNEAYPSMPVGIIGWRDLPSAGDEILEVESEPRAREVVDWRKYEQEQEKNKEDLKLIEEKRKEHQEAHRKDREKYGTVHWKERSYIKYREKRQQQPLKPKEKLERDSNVLPVIVKGDVDGSVEAILNVMDTYDASHECELDLVHFGVGDISENDVNLAETFHGVIYGFNVNAGNVIQQLAAKKGVKIKLHKIIYRLIEDLQEELSSRLPCIVEEHPIGEASILATFSITEGKKKVPVAGCRVQKGQIEKQKKFKLIRNGHVIWKGSLISLKHHKDDTSVVKTGMDCGLSLDEEKIEFKVGDAIICYEEKEVPAKTSWDPGF", "length": 752, "header": "tr|A0AAF6Z1J5-1|A0AAF6Z1J5_BOVIN Isoform 1 of Translation initiation factor IF-2, mitochondrial OS=Bos taurus OX=9913 GN=MTIF2 PE=3 SV=1 CANONICAL=A0AAF6Z1J5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV99/entry", "sequence": { "sequence": "MNRKILKLENLLRFHTICRQLHSLCQRRMLAQWRHMFSSAYAVHTAQLYTRPWQTDALLRAALSQRRLLVTKKEKRSQKSPLPSTKSKKEVEVWLGMTVEELARAMEKDIDCVYESLMNTAIDIDSLETHSRLDEVWIKEVIKKSGMKLKWSKLKQDKVRENKDAVKRPQADPALLIPRSPVVTIMGHVDHGKTTLLDKLRKTQVAAMEAGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVESIQHAKDAHVPIVLAINKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVHVSALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFTDKGRGPVTTAIIQRGTLRKGSILVAGKSWAKVRLMFDENGRAVNEAYPSMPVGIIGWRDLPSAGDEILEVESEPRAREVVDWRKYEQEQEKNKEDLKLIEEKRKEHQEAHRKDREKYGTVHWKERSYIKYREKRQQQPLKPKEKLERDSNVLPVIVKGDVDGSVEAILNVMDTYDASHECELDLVHFGVGDISENDVNLAETFHGVIYGFNVNAGNVIQQLAAKKGVKIKLHKIIYRLIEDLQEELSSRLPCIVEEHPIGEASILATFSITEGKKKVPVAGCRVQKGQIEKQKKFKLIRNGHVIWKGKQHKTVSFISSH", "length": 683, "header": "tr|A0AAA9SV99-1|A0AAF6Z1J5_BOVIN Computationally mapped isoform of Translation initiation factor IF-2, mitochondrial OS=Bos taurus OX=9913 GN=MTIF2 PE=3 SV=1 CANONICAL=A0AAF6Z1J5-1" }, "locus": { "chromosome": "11", "start_pos": 37993721, "end_pos": 37974414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087114.1" } ] } }, { "isoform_ac": "A0AAF6Z1J5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5/entry", "sequence": { "sequence": "MDCPAGPEGDLRPLQNPGVLGPRRNMNRKILKLENLLRFHTICRQLHSLCQRRMLAQWRHMFSSAYAVHTAQLYTRPWQTDALLRAALSQRRLLVTKKEKRSQKSPLPSTKSKKEVEVWLGMTVEELARAMEKDIDCVYESLMNTAIDIDSLETHSRLDEVWIKEVIKKSGMKLKWSKLKQDKVRENKDAVKRPQADPALLIPRSPVVTIMGHVDHGKTTLLDKLRKTQVAAMEAGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVESIQHAKDAHVPIVLAINKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVHVSALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFTDKGRGPVTTAIIQRGTLRKGSILVAGKSWAKVRLMFDENGRAVNEAYPSMPVGIIGWRDLPSAGDEILEVESEPRAREVVDWRKYEQEQEKNKEDLKLIEEKRKEHQEAHRKDREKYGTVHWKERSYIKYREKRQQQPLKPKEKLERDSNVLPVIVKGDVDGSVEAILNVMDTYDASHECELDLVHFGVGDISENDVNLAETFHGVIYGFNVNAGNVIQQLAAKKGVKIKLHKIIYRLIEDLQEELSSRLPCIVEEHPIGEASILATFSITEGKKKVPVAGCRVQKGQIEKQKKFKLIRNGHVIWKGSLISLKHHKDDTSVVKTGMDCGLSLDEEKIEFKVGDAIICYEEKEVPAKTSWDPGF", "length": 752, "header": "tr|A0AAF6Z1J5-1|A0AAF6Z1J5_BOVIN Isoform 1 of Translation initiation factor IF-2, mitochondrial OS=Bos taurus OX=9913 GN=MTIF2 PE=3 SV=1 CANONICAL=A0AAF6Z1J5-1" }, "locus": { "chromosome": "11", "start_pos": 37996092, "end_pos": 37973551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020573.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020573.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020573.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020573.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "pmid": "" }, { "name": "intracellular organelle lumen", "id": "GO:0070013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070013", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "formation of translation preinitiation complex", "id": "GO:0001731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001731", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1J5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z1J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1J5" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 373, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0X4-1", "uniprot_ac": "A0AAF6Z0X4", "uniprot_id": "A0AAF6Z0X4_BOVIN", "mass": { "chemical_mass": 41294.0, "monoisotopic_mass": 41294.0 }, "refseq": {}, "gene_names": [ { "name": "RABEPK", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4" } ] } ], "protein_names": [ { "name": "Rab9 effector protein with kelch motifs", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Rab9 effector required for endosome to trans-Golgi network (TGN) transport.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWB5#function" }, { "database": "UniProtKB", "id": "ARBA00037224", "url": "https://www.uniprot.org/uniprotkb/ARBA00037224#function" }, { "database": "UniProtKB", "id": "A0AAA9TZI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI3#function" }, { "database": "UniProtKB", "id": "A0AAF6Z0X4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4#function" }, { "database": "UniProtKB", "id": "A0AAF7ACF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACF6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0X4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABEPK", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4", "locus": { "chromosome": "11", "start_pos": 96114095, "end_pos": 96085411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015098", "url": "https://www.ensembl.org/id/ENSBTAG00000015098" } ] } } ], "crossref": [ { "id": "A0AAF6Z0X4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0X4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46647", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46647", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46647:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46647:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0X4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ACF6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ACF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQLPVLEPGDKPRKETWYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLGTHQWDLATSEGLLPRYEHTSFIPSCTPHSIWVFGGADQSGNRNCLQVLNPDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIDFFSPPKIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 380, "header": "tr|A0AAF6Z0X4-1|A0AAF6Z0X4_BOVIN Isoform 1 of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=4 SV=1 CANONICAL=A0AAF6Z0X4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWB5/entry", "sequence": { "sequence": "MKQLPVLEPGDKPRKETWYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 321, "header": "tr|A0AAA9SWB5-1|A0AAF6Z0X4_BOVIN Computationally mapped isoform of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=4 SV=1 CANONICAL=A0AAF6Z0X4-1" }, "locus": { "chromosome": "11", "start_pos": 96113903, "end_pos": 96092427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122143.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122143.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088320.1" } ] } }, { "isoform_ac": "A0AAA9TZI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI3/entry", "sequence": { "sequence": "AFSSPEYLQLKIGYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLGTHQWDLATSEGLLPRYEHTSFIPSCTPHSIWVFGGADQSGNRNCLQVLNPDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 367, "header": "tr|A0AAA9TZI3-1|A0AAF6Z0X4_BOVIN Computationally mapped isoform of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=4 SV=1 CANONICAL=A0AAF6Z0X4-1" }, "locus": { "chromosome": "11", "start_pos": 96113903, "end_pos": 96085610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123539.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123539.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103732.1" } ] } }, { "isoform_ac": "A0AAF6Z0X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0X4/entry", "sequence": { "sequence": "MKQLPVLEPGDKPRKETWYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLGTHQWDLATSEGLLPRYEHTSFIPSCTPHSIWVFGGADQSGNRNCLQVLNPDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIDFFSPPKIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 380, "header": "tr|A0AAF6Z0X4-1|A0AAF6Z0X4_BOVIN Isoform 1 of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=4 SV=1 CANONICAL=A0AAF6Z0X4-1" }, "locus": { "chromosome": "11", "start_pos": 96113903, "end_pos": 96092427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020093.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020093.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020093.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020093.5" } ] } }, { "isoform_ac": "A0AAF7ACF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACF6/entry", "sequence": { "sequence": "SEGLRPAPTGAEPRPRTGLNRRRYTLTLVGDSPCARVGHSCSYLPPVGDAERGKVFIVGGADPNRSFSDVHTIDLGTHQWDLATSEGLLPRYEHTSFIPSCTPHSIWVFGGADQSGNRNCLQVLNPDTRTWTTPEVTGPPPSPRTFHTSSAAIGDQLYVFGGGERGAQPVQDVQLHVFDANTLTWSQPETHGKPPSPRHGHVMVAAGTKLFIHGGLAGDNFYDDLHCIDISDMKWQKLRPTGAAPTGCAAHSAVAVGKHLYVFGGMTPTGALNTMYQYHIEKQHWTLLKFENSPPTGRLDHSMCIIPWPGTCTSEKEDSNSATVNRDAEKGDSTEKGVTQGGDSQEESQADTLLCFVFGGMNTEGEIYDDCIVTAVD", "length": 377, "header": "tr|A0AAF7ACF6-1|A0AAF7ACF6_BOVIN Computationally mapped isoform of Rab9 effector protein with kelch motifs OS=Bos taurus OX=9913 GN=RABEPK PE=4 SV=1 CANONICAL=A0AAF6Z0X4-1" }, "locus": { "chromosome": "11", "start_pos": 96113903, "end_pos": 96091178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074576.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074576.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066540.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066540.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZD23-1", "uniprot_ac": "A0AAF6ZD23", "uniprot_id": "A0AAF6ZD23_BOVIN", "mass": { "chemical_mass": 24072.0, "monoisotopic_mass": 24072.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM54", "type": "recommended", "evidence": [ { "id": "A0AAF6ZD23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23" } ] } ], "protein_names": [ { "name": "Transmembrane protein 54", "type": "synonym", "evidence": [ { "id": "A0AAF6ZD23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZD23", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM54", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23", "locus": { "chromosome": "2", "start_pos": 120780411, "end_pos": 120773204, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008331", "url": "https://www.ensembl.org/id/ENSBTAG00000008331" } ] } } ], "crossref": [ { "id": "A0AAF6ZD23", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZD23", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR020977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31258:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31258:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12304", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12304", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWI4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1V0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1V0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD23", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALMWLSLPGGLSVGDFRKVLMKTGLVLVVLGHVSFIAAALLHGTVLRYVAAPNDAVALQYCVVDILSVTSAIVVITSGISVIVLSRYLPSIPLRWTVFSSSVACALLSLTCALGLLASIAMTFATQGRALLAACTFGGPERLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRSAQLAYQVLELRPWLGKSSHRMMQESPEPVEDPDLPSRTSSGPMTL", "length": 226, "header": "tr|A0AAF6ZD23-1|A0AAF6ZD23_BOVIN Isoform 1 of Transmembrane protein 54 OS=Bos taurus OX=9913 GN=TMEM54 PE=3 SV=1 CANONICAL=A0AAF6ZD23-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWI4/entry", "sequence": { "sequence": "MGFSRQEYWSGLPLPSPRDLEFYSIKCPAAAAALLQSCPTLCDPIDGSPPGSAVPGILQVITSGISVIVLSRYLPSIPLRWTVFSSSVACALLSLTCALGLLASIAMTFATQGRALLAACTFGGPERLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRSAQLAYQVLELRPWLGKSSHRMMQESPEPVEDPDLPSRTSSGPMTL", "length": 211, "header": "tr|A0AAA9SWI4-1|A0AAF6ZD23_BOVIN Computationally mapped isoform of Transmembrane protein 54 OS=Bos taurus OX=9913 GN=TMEM54 PE=3 SV=1 CANONICAL=A0AAF6ZD23-1" }, "locus": { "chromosome": "2", "start_pos": 120779803, "end_pos": 120777895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107431.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107431.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088585.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088585.1" } ] } }, { "isoform_ac": "A0AAA9T1V0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V0/entry", "sequence": { "sequence": "MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFIAAALLHGTVLRYVAAPNDAVALQYCVVDILSVTSAIVGRALLAACTFGGPERLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRSAQLAYQVLELRPWLGKSSHRMMQESPEPVEDPDLPSRTSSGPMTL", "length": 169, "header": "tr|A0AAA9T1V0-1|A0AAF6ZD23_BOVIN Computationally mapped isoform of Transmembrane protein 54 OS=Bos taurus OX=9913 GN=TMEM54 PE=3 SV=1 CANONICAL=A0AAF6ZD23-1" }, "locus": { "chromosome": "2", "start_pos": 120779803, "end_pos": 120773353, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125534.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125534.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091718.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091718.1" } ] } }, { "isoform_ac": "A0AAF6ZD23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23/entry", "sequence": { "sequence": "MALMWLSLPGGLSVGDFRKVLMKTGLVLVVLGHVSFIAAALLHGTVLRYVAAPNDAVALQYCVVDILSVTSAIVVITSGISVIVLSRYLPSIPLRWTVFSSSVACALLSLTCALGLLASIAMTFATQGRALLAACTFGGPERLALAPDCPFDPTRIYSSSLCLWGISLLFCVAESVFAVRSAQLAYQVLELRPWLGKSSHRMMQESPEPVEDPDLPSRTSSGPMTL", "length": 226, "header": "tr|A0AAF6ZD23-1|A0AAF6ZD23_BOVIN Isoform 1 of Transmembrane protein 54 OS=Bos taurus OX=9913 GN=TMEM54 PE=3 SV=1 CANONICAL=A0AAF6ZD23-1" }, "locus": { "chromosome": "2", "start_pos": 120779803, "end_pos": 120775560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038048.3", "url": "https://www.ensembl.org/id/ENSBTAT00000038048.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037867.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037867.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZD23", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z715-1", "uniprot_ac": "A0AAF6Z715", "uniprot_id": "A0AAF6Z715_BOVIN", "mass": { "chemical_mass": 52406.0, "monoisotopic_mass": 52406.0 }, "refseq": {}, "gene_names": [ { "name": "SNX17", "type": "recommended", "evidence": [ { "id": "A0AAF6Z715", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ] } ], "protein_names": [ { "name": "Sorting nexin-17", "type": "recommended", "evidence": [ { "id": "A0AAF6Z715", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715#function" }, { "database": "UniProtKB", "id": "ARBA00045612", "url": "https://www.uniprot.org/uniprotkb/ARBA00045612#function" }, { "database": "UniProtKB", "id": "A0AAA9SWW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX17", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715", "locus": { "chromosome": "11", "start_pos": 72286895, "end_pos": 72292726, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019515", "url": "https://www.ensembl.org/id/ENSBTAG00000019515" } ] } } ], "crossref": [ { "id": "A0AAF6Z715", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z715", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06885", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06885", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13337", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13337", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529972", "url": "https://www.ncbi.nlm.nih.gov/gene/529972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12431:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12431:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18116", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18116", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z715-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVADIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLVSDAAASSSPGVTGRQPGVHGQTLKQAECCEPAGDWHSWYRCQCQ", "length": 464, "header": "tr|A0AAF6Z715-1|A0AAF6Z715_BOVIN Isoform 1 of Sorting nexin-17 OS=Bos taurus OX=9913 GN=SNX17 PE=3 SV=1 CANONICAL=A0AAF6Z715-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW2/entry", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVADIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGTPGTDASASDVHGNFAFEGIGDEDL", "length": 445, "header": "tr|A0AAA9SWW2-1|A0AAF6Z715_BOVIN Computationally mapped isoform of Sorting nexin-17 OS=Bos taurus OX=9913 GN=SNX17 PE=3 SV=1 CANONICAL=A0AAF6Z715-1" }, "locus": { "chromosome": "11", "start_pos": 72292576, "end_pos": 72287297, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115118.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115118.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088556.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088556.1" } ] } }, { "isoform_ac": "A0AAF6Z715-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715/entry", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVADIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLVSDAAASSSPGVTGRQPGVHGQTLKQAECCEPAGDWHSWYRCQCQ", "length": 464, "header": "tr|A0AAF6Z715-1|A0AAF6Z715_BOVIN Isoform 1 of Sorting nexin-17 OS=Bos taurus OX=9913 GN=SNX17 PE=3 SV=1 CANONICAL=A0AAF6Z715-1" }, "locus": { "chromosome": "11", "start_pos": 72292576, "end_pos": 72287346, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025998.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025998.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025998.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025998.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor binding", "id": "GO:0050750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050750", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z715", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z715", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 109, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z715", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z715" }, { "id": "PS50200", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-associating", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 206, "start_aa": "Glu", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZFL5-1", "uniprot_ac": "A0AAF6ZFL5", "uniprot_id": "A0AAF6ZFL5_BOVIN", "mass": { "chemical_mass": 59542.0, "monoisotopic_mass": 59542.0 }, "refseq": {}, "gene_names": [ { "name": "RASGEF1B", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5" } ] } ], "protein_names": [ { "name": "RasGEF domain family member 1B", "type": "synonym", "evidence": [ { "id": "A0AAF6ZFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RASGEF1B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5", "locus": { "chromosome": "6", "start_pos": 96214372, "end_pos": 96271970, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006561", "url": "https://www.ensembl.org/id/ENSBTAG00000006561" } ] } } ], "crossref": [ { "id": "A0AAF6ZFL5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZFL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00155", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113:SF197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00617", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00617", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00618", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00618", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T047", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T047", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T047-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T047-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPNSDKNQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEFPYDFVELWVGKIPWRRKWQPTPVFLPGEFHGQRSMTYRKNVQQMIQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDVLEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQHLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV", "length": 508, "header": "tr|A0AAF6ZFL5-1|A0AAF6ZFL5_BOVIN Isoform 1 of RasGEF domain family member 1B OS=Bos taurus OX=9913 GN=RASGEF1B PE=4 SV=1 CANONICAL=A0AAF6ZFL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T047-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T047/entry", "sequence": { "sequence": "MENLVEDVLKKDGEVSVEIMLERIEKESMPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPNSDKNQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMIQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDVLEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQHLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV", "length": 500, "header": "tr|A0AAA9T047-1|A0AAF6ZFL5_BOVIN Computationally mapped isoform of RasGEF domain family member 1B OS=Bos taurus OX=9913 GN=RASGEF1B PE=4 SV=1 CANONICAL=A0AAF6ZFL5-1" }, "locus": { "chromosome": "6", "start_pos": 96245613, "end_pos": 96215759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093256.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093256.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089761.1" } ] } }, { "isoform_ac": "A0AAA9TAJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ4/entry", "sequence": { "sequence": "MPGPKESMPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPNSDKNQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMIQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDVLEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQHLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV", "length": 479, "header": "tr|A0AAA9TAJ4-1|A0AAF6ZFL5_BOVIN Computationally mapped isoform of RasGEF domain family member 1B OS=Bos taurus OX=9913 GN=RASGEF1B PE=4 SV=1 CANONICAL=A0AAF6ZFL5-1" }, "locus": { "chromosome": "6", "start_pos": 96271832, "end_pos": 96215759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096014.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096014.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095017.1" } ] } }, { "isoform_ac": "A0AAA9TQ96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ96/entry", "sequence": { "sequence": "MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDNQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEETYRKNVQQMIQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDVLEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQHLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV", "length": 431, "header": "tr|A0AAA9TQ96-1|A0AAF6ZFL5_BOVIN Computationally mapped isoform of RasGEF domain family member 1B OS=Bos taurus OX=9913 GN=RASGEF1B PE=4 SV=1 CANONICAL=A0AAF6ZFL5-1" }, "locus": { "chromosome": "6", "start_pos": 96240258, "end_pos": 96215759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125523.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125523.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100753.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100753.1" } ] } }, { "isoform_ac": "A0AAF6ZFL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5/entry", "sequence": { "sequence": "MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPNSDKNQIRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEFPYDFVELWVGKIPWRRKWQPTPVFLPGEFHGQRSMTYRKNVQQMIQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDVLEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQHLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV", "length": 508, "header": "tr|A0AAF6ZFL5-1|A0AAF6ZFL5_BOVIN Isoform 1 of RasGEF domain family member 1B OS=Bos taurus OX=9913 GN=RASGEF1B PE=4 SV=1 CANONICAL=A0AAF6ZFL5-1" }, "locus": { "chromosome": "6", "start_pos": 96240258, "end_pos": 96215759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045329.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045329.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042728.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042728.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5" }, { "id": "PS50212", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50212" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "N-terminal Ras-GEF", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 164, "start_aa": "His", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFL5" }, { "id": "PS50009", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50009" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-GEF", "eco_id": "ECO_0000259", "start_pos": 240, "end_pos": 488, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 348, "end_pos": 350 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZBI8-1", "uniprot_ac": "A0AAF6ZBI8", "uniprot_id": "A0AAF6ZBI8_BOVIN", "mass": { "chemical_mass": 50163.0, "monoisotopic_mass": 50163.0 }, "refseq": { "ac": "XP_005203936", "name": "CUGBP Elav-like family member 3 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203936" }, "gene_names": [ { "name": "CELF3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ] }, { "name": "CELF3", "type": "synonym", "evidence": [ { "id": "XP_005203936", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203936" } ] }, { "name": "TNRC4", "type": "synonym", "evidence": [ { "id": "XP_005203936", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203936" } ] } ], "protein_names": [ { "name": "CUGBP Elav-like family member 3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry#names_and_taxonomy" } ] }, { "name": "Bruno-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry#names_and_taxonomy" } ] }, { "name": "CUG-BP- and ETR-3-like factor 3", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry#names_and_taxonomy" } ] }, { "name": "CUGBP Elav-like family member 3 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_005203936", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203936" } ] }, { "name": "ELAV-type RNA-binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein BRUNOL-1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry#names_and_taxonomy" } ] }, { "name": "Trinucleotide repeat-containing gene 4 protein", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8#function" }, { "database": "UniProtKB", "id": "ARBA00055885", "url": "https://www.uniprot.org/uniprotkb/ARBA00055885#function" }, { "database": "UniProtKB", "id": "A0AAA9T2I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2I3#function" }, { "database": "UniProtKB", "id": "A0AAA9U1I9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CELF3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8", "locus": { "chromosome": "3", "start_pos": 19081185, "end_pos": 19066637, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019131", "url": "https://www.ensembl.org/id/ENSBTAG00000019131" } ] } } ], "crossref": [ { "id": "A0AAF6ZBI8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZBI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12632", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12632", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12635", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12635", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12639", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12639", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513347", "url": "https://www.ncbi.nlm.nih.gov/gene/513347", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203936", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203936", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2I3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1I9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1I9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAAYPAAYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY", "length": 462, "header": "tr|A0AAF6ZBI8-1|A0AAF6ZBI8_BOVIN Isoform 1 of CUGBP Elav-like family member 3 OS=Bos taurus OX=9913 GN=CELF3 PE=3 SV=1 CANONICAL=A0AAF6ZBI8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2I3/entry", "sequence": { "sequence": "MSKVTQLVSGRASPQSLSSAFPEGYFGPTLGMWMDGCFCLFFWPLEQGQLHQQMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAYPAAYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY", "length": 438, "header": "tr|A0AAA9T2I3-1|A0AAF6ZBI8_BOVIN Computationally mapped isoform of CUGBP Elav-like family member 3 OS=Bos taurus OX=9913 GN=CELF3 PE=3 SV=1 CANONICAL=A0AAF6ZBI8-1" }, "locus": { "chromosome": "3", "start_pos": 19078595, "end_pos": 19072255, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089869.1" } ] } }, { "isoform_ac": "A0AAA9U1I9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I9/entry", "sequence": { "sequence": "MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSAQSPAAPVDPLQQAYAGMQHYTAAYPAAYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY", "length": 412, "header": "tr|A0AAA9U1I9-1|A0AAF6ZBI8_BOVIN Computationally mapped isoform of CUGBP Elav-like family member 3 OS=Bos taurus OX=9913 GN=CELF3 PE=3 SV=1 CANONICAL=A0AAF6ZBI8-1" }, "locus": { "chromosome": "3", "start_pos": 19078595, "end_pos": 19066969, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118824.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118824.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103088.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103088.1" } ] } }, { "isoform_ac": "A0AAF6ZBI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8/entry", "sequence": { "sequence": "MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAAYPAAYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY", "length": 462, "header": "tr|A0AAF6ZBI8-1|A0AAF6ZBI8_BOVIN Isoform 1 of CUGBP Elav-like family member 3 OS=Bos taurus OX=9913 GN=CELF3 PE=3 SV=1 CANONICAL=A0AAF6ZBI8-1" }, "locus": { "chromosome": "3", "start_pos": 19078595, "end_pos": 19066969, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033848.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033848.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033756.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033756.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 254, "start_aa": "Thr", "end_pos": 254, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr254", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "7SK snRNA binding", "id": "GO:0097322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097322", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "positive regulation of mRNA splicing, via spliceosome", "id": "GO:0048026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048026", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBI8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZBI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBI8" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 88, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 254 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 415, "end_pos": 417 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z672-1", "uniprot_ac": "A0AAF6Z672", "uniprot_id": "A0AAF6Z672_BOVIN", "mass": { "chemical_mass": 49702.0, "monoisotopic_mass": 49702.0 }, "refseq": {}, "gene_names": [ { "name": "TUFM", "type": "recommended", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ], "protein_names": [ { "name": "Elongation factor Tu", "type": "recommended", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672#function" }, { "database": "UniProtKB", "id": "ARBA00094234", "url": "https://www.uniprot.org/uniprotkb/ARBA00094234#function" }, { "database": "UniProtKB", "id": "A0AAA9T2K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2K2#function" } ] }, { "annotation": "This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672#function" }, { "database": "UniProtKB", "id": "RU000325", "url": "https://www.uniprot.org/uniprotkb/RU000325#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUFM", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672", "locus": { "chromosome": "25", "start_pos": 25971740, "end_pos": 25967782, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019216", "url": "https://www.ensembl.org/id/ENSBTAG00000019216" } ] } } ], "crossref": [ { "id": "A0AAF6Z672", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z672", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01884", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01884", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03697", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03697", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03706", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03706", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43721", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43721", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43721:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43721:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03143", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03143", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T2K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2K2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2K2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z672-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TTTMAAATLLRATPLFSGLGAGPAPLLQGLLRPLKAQALPVLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPIIVGSALCALEQRDPELGLKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECEFLGHSKNIRTVVTGIEMFHKSLDRAEAGDNLGALVRGLKREDLRRGLVMAKPGSIQPHQKVEAQVYILTKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPGKELAMPGEDLKLTLILRQPMILEKGQRFTLRDGNRTIGTGLVTDTPAMTEEDKNIKWS", "length": 455, "header": "tr|A0AAF6Z672-1|A0AAF6Z672_BOVIN Isoform 1 of Elongation factor Tu OS=Bos taurus OX=9913 GN=TUFM PE=3 SV=1 CANONICAL=A0AAF6Z672-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2K2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2K2/entry", "sequence": { "sequence": "MRKRRRFDPWGRGDPLEKGMAIYSSILAWRILWTEEPVHRLSFSKVERALLKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPIIVGSALCALEQRDPELGLKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECEFLGHSKNIRTVVTGIEMFHKSLDRAEAGDNLGALVRGLKREDLRRGLVMAKPGSIQPHQKVEAQVYILTKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPGKELAMPGEDLKLTLILRQPMILEKGQRFTLRDGNRTIGTGLVTDTPAMTEEDKNIKWS", "length": 425, "header": "tr|A0AAA9T2K2-1|A0AAF6Z672_BOVIN Computationally mapped isoform of Elongation factor Tu OS=Bos taurus OX=9913 GN=TUFM PE=3 SV=1 CANONICAL=A0AAF6Z672-1" }, "locus": { "chromosome": "25", "start_pos": 25971543, "end_pos": 25968362, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089628.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089628.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093022.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093022.1" } ] } }, { "isoform_ac": "A0AAF6Z672-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672/entry", "sequence": { "sequence": "TTTMAAATLLRATPLFSGLGAGPAPLLQGLLRPLKAQALPVLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPIIVGSALCALEQRDPELGLKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECEFLGHSKNIRTVVTGIEMFHKSLDRAEAGDNLGALVRGLKREDLRRGLVMAKPGSIQPHQKVEAQVYILTKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPGKELAMPGEDLKLTLILRQPMILEKGQRFTLRDGNRTIGTGLVTDTPAMTEEDKNIKWS", "length": 455, "header": "tr|A0AAF6Z672-1|A0AAF6Z672_BOVIN Isoform 1 of Elongation factor Tu OS=Bos taurus OX=9913 GN=TUFM PE=3 SV=1 CANONICAL=A0AAF6Z672-1" }, "locus": { "chromosome": "25", "start_pos": 25971543, "end_pos": 25967839, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025586.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025586.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025586.2", "url": "https://www.ensembl.org/id/ENSBTAP00000025586.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial large ribosomal subunit assembly", "id": "GO:1902775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902775", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z672", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 254, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.3", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3" }, { "id": "3.6.5.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 431, "end_pos": 433 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z796-1", "uniprot_ac": "A0AAF6Z796", "uniprot_id": "A0AAF6Z796_BOVIN", "mass": { "chemical_mass": 35100.0, "monoisotopic_mass": 35100.0 }, "refseq": {}, "gene_names": [ { "name": "RNF138", "type": "recommended", "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase RNF138", "type": "recommended", "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 138", "type": "synonym", "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase RNF138", "type": "synonym", "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF138", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796", "locus": { "chromosome": "24", "start_pos": 25079284, "end_pos": 25119233, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020160", "url": "https://www.ensembl.org/id/ENSBTAG00000020160" } ] } } ], "crossref": [ { "id": "A0AAF6Z796", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z796", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16544", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16544", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46968:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46968:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T398", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T398", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T398-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T398-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z796-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCTTYSARLSPPGLAREGGNGWTRSPTTAPGFSTNTRPGRSLAPGRHRHPGRCRRHRLHPSSPTMAEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSASDNIETYQENTGSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQVTRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI", "length": 309, "header": "tr|A0AAF6Z796-1|A0AAF6Z796_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF138 OS=Bos taurus OX=9913 GN=RNF138 PE=4 SV=1 CANONICAL=A0AAF6Z796-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T398-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T398/entry", "sequence": { "sequence": "MAEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVNRSETSASDNIETYQENTGSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQVTRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI", "length": 151, "header": "tr|A0AAA9T398-1|A0AAF6Z796_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RNF138 OS=Bos taurus OX=9913 GN=RNF138 PE=4 SV=1 CANONICAL=A0AAF6Z796-1" }, "locus": { "chromosome": "24", "start_pos": 25118287, "end_pos": 25079401, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118112.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118112.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091101.1" } ] } }, { "isoform_ac": "A0AAF6Z796-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796/entry", "sequence": { "sequence": "MCTTYSARLSPPGLAREGGNGWTRSPTTAPGFSTNTRPGRSLAPGRHRHPGRCRRHRLHPSSPTMAEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSASDNIETYQENTGSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQVTRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI", "length": 309, "header": "tr|A0AAF6Z796-1|A0AAF6Z796_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF138 OS=Bos taurus OX=9913 GN=RNF138 PE=4 SV=1 CANONICAL=A0AAF6Z796-1" }, "locus": { "chromosome": "24", "start_pos": 25119058, "end_pos": 25079401, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026851.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026851.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026851.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026851.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" }, { "name": "DNA double-strand break processing involved in repair via single-strand annealing", "id": "GO:0010792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010792", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z796", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" }, { "id": "PS51803", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51803" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2HC RNF-type", "eco_id": "ECO_0000259", "start_pos": 150, "end_pos": 169, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z796" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 122, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 230, "end_pos": 232 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4S9-1", "uniprot_ac": "A0AAF6Z4S9", "uniprot_id": "A0AAF6Z4S9_BOVIN", "mass": { "chemical_mass": 66754.0, "monoisotopic_mass": 66754.0 }, "refseq": {}, "gene_names": [ { "name": "C16H1orf116", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9" } ] } ], "protein_names": [ { "name": "Chromosome 16 C1orf116 homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6Z4S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C16H1orf116", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9", "locus": { "chromosome": "16", "start_pos": 4833636, "end_pos": 4845241, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018143", "url": "https://www.ensembl.org/id/ENSBTAG00000018143" } ] } } ], "crossref": [ { "id": "A0AAF6Z4S9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4S9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21555", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21555", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21555:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21555:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15385", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15385", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T4C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4S9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPLPVQAQPGTFFTSLHFPSGSPFHHPCTLLQAMPERELWPAGPGLEPATRVGSCDSMMSTTSTRSGSSDSSYDFLSAEEKECLLFLEETIGSLDTEADSGLSTEKSEQATTPQVPRALPKTQPAPQGHPEEITGRVPEPKRVTPFSSAHPPGPQSLGLRSGSYSLPRNIHIGRNQNLRKSTTLTNSHNPGGSEGLVSGPETEQVSQSREPRQTLATPPDAALELDGALIPPPEAFRDTQPQQRGQGSLPRGPGELSPRPQVHPSLSSQRNREPAPEAMSQKASEKGSTGEPVPPRPPPLVSSRDAGSGDAAVLSGGHPSARPAPLTAPKPRKLPPNIVLKSSRSSFHSDPQNRLSRHSEAAPGDPSPASSSLQEQRKARREALEKLGLPQDQEEPSPRLSRPSVRLKETGVQAVSPAPAQVPGRAPAAAPTQGPSPGKAPALAQPPSPGKVLVPAQESTPGTAPAAKSTPIPIPKGPRAHSPLTQRKPDSGLTLQESGVPGLRQMSFKSNTLERSGIGLSSYLSAEKASSPQTSTSLEKGSFLDRISPSVLRNSRPRPASLGTGKDFEGIQVGKLADLEQEGGPKRLSFQGQSRDKLPRPPCVSVRISPKGVSDEHRREALKKLGLLKE", "length": 631, "header": "tr|A0AAF6Z4S9-1|A0AAF6Z4S9_BOVIN Isoform 1 of Chromosome 16 C1orf116 homolog OS=Bos taurus OX=9913 GN=C16H1orf116 PE=4 SV=1 CANONICAL=A0AAF6Z4S9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4C1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C1/entry", "sequence": { "sequence": "MRLQEIRRGRGSLNFSGWHLEGLVRECEMMLRLSRWRQRWHVSVAIHPKKTVPLVLGLQSLLHTLGHPEEITGRVPEPKRVTPFSSAHPPGPQSLGLRSGSYSLPRNIHIGRNQNLRKSTTLTNSHNPGGSEGLVSGPETEQVSQSREPRQTLATPPDAALELDGALIPPPEAFRDTQPQQRGQGSLPRGPGELSPRPQVHPSLSSQRNREPAPEAMSQKASEKGSTGEPVPPRPPPLVSSRDAGSGDAAVLSGGHPSARPAPLTAPKPRKLPPNIVLKSSRSSFHSDPQNRLSRHSEAAPGDPSPASSSLQEQRKARREALEKLGLPQDQEEPSPRLSRPSVRLKETGVQAVSPAPAQVPGRAPAAAPTQGPSPGKAPALAQPPSPGKVLVPAQESTPGTAPAAKSTPIPIPKGPRAHSPLTQRKPDSGLTLQESGVPGLRQMSFKSNTLERSGIGLSSYLSAEKASSPQTSTSLEKGSFLDRISPSVLRNSRPRPASLGTGKDFEGIQVGKLADLEQEGGPKRLSFQGQSRDKLPRPPCVSVRISPKGVSDEHRREALKKLGLLKE", "length": 568, "header": "tr|A0AAA9T4C1-1|A0AAF6Z4S9_BOVIN Computationally mapped isoform of Chromosome 16 C1orf116 homolog OS=Bos taurus OX=9913 GN=C16H1orf116 PE=4 SV=1 CANONICAL=A0AAF6Z4S9-1" }, "locus": { "chromosome": "16", "start_pos": 4836935, "end_pos": 4834579, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120564.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120564.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093632.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093632.1" } ] } }, { "isoform_ac": "A0AAF6Z4S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9/entry", "sequence": { "sequence": "MKPLPVQAQPGTFFTSLHFPSGSPFHHPCTLLQAMPERELWPAGPGLEPATRVGSCDSMMSTTSTRSGSSDSSYDFLSAEEKECLLFLEETIGSLDTEADSGLSTEKSEQATTPQVPRALPKTQPAPQGHPEEITGRVPEPKRVTPFSSAHPPGPQSLGLRSGSYSLPRNIHIGRNQNLRKSTTLTNSHNPGGSEGLVSGPETEQVSQSREPRQTLATPPDAALELDGALIPPPEAFRDTQPQQRGQGSLPRGPGELSPRPQVHPSLSSQRNREPAPEAMSQKASEKGSTGEPVPPRPPPLVSSRDAGSGDAAVLSGGHPSARPAPLTAPKPRKLPPNIVLKSSRSSFHSDPQNRLSRHSEAAPGDPSPASSSLQEQRKARREALEKLGLPQDQEEPSPRLSRPSVRLKETGVQAVSPAPAQVPGRAPAAAPTQGPSPGKAPALAQPPSPGKVLVPAQESTPGTAPAAKSTPIPIPKGPRAHSPLTQRKPDSGLTLQESGVPGLRQMSFKSNTLERSGIGLSSYLSAEKASSPQTSTSLEKGSFLDRISPSVLRNSRPRPASLGTGKDFEGIQVGKLADLEQEGGPKRLSFQGQSRDKLPRPPCVSVRISPKGVSDEHRREALKKLGLLKE", "length": 631, "header": "tr|A0AAF6Z4S9-1|A0AAF6Z4S9_BOVIN Isoform 1 of Chromosome 16 C1orf116 homolog OS=Bos taurus OX=9913 GN=C16H1orf116 PE=4 SV=1 CANONICAL=A0AAF6Z4S9-1" }, "locus": { "chromosome": "16", "start_pos": 4845115, "end_pos": 4834579, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024149.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024149.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024149.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024149.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 461, "start_aa": "Thr", "end_pos": 461, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr461", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 461 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZHS4-1", "uniprot_ac": "A0AAF6ZHS4", "uniprot_id": "A0AAF6ZHS4_BOVIN", "mass": { "chemical_mass": 44119.0, "monoisotopic_mass": 44119.0 }, "refseq": {}, "gene_names": [ { "name": "DDAH1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZHS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ] } ], "protein_names": [ { "name": "Dimethylarginine dimethylaminohydrolase 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZHS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDAH1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4", "locus": { "chromosome": "3", "start_pos": 58775117, "end_pos": 58617898, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034776", "url": "https://www.ensembl.org/id/ENSBTAG00000034776" } ] } } ], "crossref": [ { "id": "A0AAF6ZHS4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZHS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR033199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12737", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12737", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12737:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12737:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02274", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02274", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19420", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19420", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T5G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSGTAPFGRGSPTQHPPAHTSRTPRFLGRRLHPDFVRRSPLQLPPGPPANPRAPSGRAGCARAGARSSGHAQSRGQGSGREQGSRCTTFAGCQGEPPGARRLGERCPHKTLPPRPAPPPRAMASLGHPATFGRATHVVVRALPESLAQQALRRTKGDEVDFARAERQHQLYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEADMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVVDALHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDTAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSNSELEKVDGLLTCSSVLINKKVDS", "length": 408, "header": "tr|A0AAF6ZHS4-1|A0AAF6ZHS4_BOVIN Isoform 1 of Dimethylarginine dimethylaminohydrolase 1 OS=Bos taurus OX=9913 GN=DDAH1 PE=3 SV=1 CANONICAL=A0AAF6ZHS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G3/entry", "sequence": { "sequence": "MADMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVVDALHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDTAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSNSELEKVDGLLTCSSVLINKKVDS", "length": 185, "header": "tr|A0AAA9T5G3-1|A0AAF6ZHS4_BOVIN Computationally mapped isoform of Dimethylarginine dimethylaminohydrolase 1 OS=Bos taurus OX=9913 GN=DDAH1 PE=3 SV=2 CANONICAL=A0AAF6ZHS4-1" }, "locus": { "chromosome": "3", "start_pos": 58772190, "end_pos": 58693140, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094006.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094006.1" } ] } }, { "isoform_ac": "A0AAF6ZHS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4/entry", "sequence": { "sequence": "MSGSGTAPFGRGSPTQHPPAHTSRTPRFLGRRLHPDFVRRSPLQLPPGPPANPRAPSGRAGCARAGARSSGHAQSRGQGSGREQGSRCTTFAGCQGEPPGARRLGERCPHKTLPPRPAPPPRAMASLGHPATFGRATHVVVRALPESLAQQALRRTKGDEVDFARAERQHQLYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEADMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVVDALHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDTAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSNSELEKVDGLLTCSSVLINKKVDS", "length": 408, "header": "tr|A0AAF6ZHS4-1|A0AAF6ZHS4_BOVIN Isoform 1 of Dimethylarginine dimethylaminohydrolase 1 OS=Bos taurus OX=9913 GN=DDAH1 PE=3 SV=1 CANONICAL=A0AAF6ZHS4-1" }, "locus": { "chromosome": "3", "start_pos": 58772190, "end_pos": 58618039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049235.5", "url": "https://www.ensembl.org/id/ENSBTAT00000049235.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046157.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046157.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "dimethylargininase activity", "id": "GO:0016403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016403", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "nitric-oxide synthase regulator activity", "id": "GO:0030235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030235", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "positive regulation of nitric oxide biosynthetic process", "id": "GO:0045429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045429", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "negative regulation of vascular permeability", "id": "GO:0043116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043116", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "regulation of systemic arterial blood pressure", "id": "GO:0003073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003073", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "L-arginine catabolic process", "id": "GO:0006527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006527", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" }, { "name": "negative regulation of cellular response to hypoxia", "id": "GO:1900038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900038", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 246, "end_pos": 248 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z288-1", "uniprot_ac": "A0AAF6Z288", "uniprot_id": "A0AAF6Z288_BOVIN", "mass": { "chemical_mass": 89587.0, "monoisotopic_mass": 89587.0 }, "refseq": {}, "gene_names": [ { "name": "RNF10", "type": "recommended", "evidence": [ { "id": "A0AAF6Z288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase RNF10", "type": "recommended", "evidence": [ { "id": "A0AAF6Z288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAF6Z288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 10", "type": "synonym", "evidence": [ { "id": "A0AAF6Z288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288", "locus": { "chromosome": "17", "start_pos": 62850443, "end_pos": 62816689, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015767", "url": "https://www.ensembl.org/id/ENSBTAG00000015767" } ] } } ], "crossref": [ { "id": "A0AAF6Z288", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z288", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16536", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16536", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12983:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12983:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T708", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T708", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T708-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T708-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z288-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQSSPSAAATASDMDKNSGSSSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKREPSYPKNENFINQSRRSNSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTVHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLRRVVQEEKAALERQLAEEKHTPESCFIEAAIQELKAREEALSGLAESRGEVPGVVAALEQRVLMAPLAKESVFQPRKGVLEYLSAFDEDATEVCSLGPPHPVALPLVEEEETVSEPEPEGLSEACEDLELVEDNLGEGTICTESSQQEPVSKPSVTHLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEISGYSMSEDMRQRHRYLSHLPLTCEFSICELALQPPLVSKETLEIFSDDIEKRKRQRQKKAREERRRERRIEMEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGSTSTEGRGALSLSPLSRSPGSQADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENTLGPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPVTSDPLSEKGGKKRKKQKQKLLFSTSVVHTK", "length": 809, "header": "tr|A0AAF6Z288-1|A0AAF6Z288_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF10 OS=Bos taurus OX=9913 GN=RNF10 PE=3 SV=1 CANONICAL=A0AAF6Z288-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T708-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T708/entry", "sequence": { "sequence": "MVRFGMCLDGSFWQFSALDGKNSSGSKRYNRKREPSYPKNENFINQSRRSNSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTVHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLRRVVQEEKAALERQLAEEKHTPESCFIEAAIQELKAREEALSGLAESRGEVPGVVAALEQRVLMAPLAKESVFQPRKGVLEYLSAFDEDATEVCSLGPPHPVALPLVEEEETVSEPEPEGLSEACEDLELVEDNLGEGTICTESSQQEPVSKPSVTHLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEISGYSMSEDMRQRHRYLSHLPLTCEFSICELALQPPLVSKETLEIFSDDIEKRKRQRQKKAREERRRERRIEMEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGSTSTEGRGALSLSPLSRSPGSQADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENTLGPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPVTSDPLSEEKGGKKRKKQKQKLLFSTSVVHTK", "length": 776, "header": "tr|A0AAA9T708-1|A0AAF6Z288_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RNF10 OS=Bos taurus OX=9913 GN=RNF10 PE=3 SV=1 CANONICAL=A0AAF6Z288-1" }, "locus": { "chromosome": "17", "start_pos": 62849439, "end_pos": 62821568, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116086.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116086.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091591.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091591.1" } ] } }, { "isoform_ac": "A0AAF6Z288-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288/entry", "sequence": { "sequence": "MPQSSPSAAATASDMDKNSGSSSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKREPSYPKNENFINQSRRSNSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTVHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLRRVVQEEKAALERQLAEEKHTPESCFIEAAIQELKAREEALSGLAESRGEVPGVVAALEQRVLMAPLAKESVFQPRKGVLEYLSAFDEDATEVCSLGPPHPVALPLVEEEETVSEPEPEGLSEACEDLELVEDNLGEGTICTESSQQEPVSKPSVTHLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEISGYSMSEDMRQRHRYLSHLPLTCEFSICELALQPPLVSKETLEIFSDDIEKRKRQRQKKAREERRRERRIEMEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGSTSTEGRGALSLSPLSRSPGSQADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENTLGPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPVTSDPLSEKGGKKRKKQKQKLLFSTSVVHTK", "length": 809, "header": "tr|A0AAF6Z288-1|A0AAF6Z288_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF10 OS=Bos taurus OX=9913 GN=RNF10 PE=3 SV=1 CANONICAL=A0AAF6Z288-1" }, "locus": { "chromosome": "17", "start_pos": 62849439, "end_pos": 62817123, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020937.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020937.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020937.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020937.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "ribosome disassembly", "id": "GO:0032790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032790", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "nonfunctional rRNA decay", "id": "GO:0070651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070651", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "ribosome-associated ubiquitin-dependent protein catabolic process", "id": "GO:1990116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990116", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z288", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z288" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 225, "end_pos": 266, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZA83-1", "uniprot_ac": "A0AAF6ZA83", "uniprot_id": "A0AAF6ZA83_BOVIN", "mass": { "chemical_mass": 29578.0, "monoisotopic_mass": 29578.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Cyclic nucleotide-binding domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZA83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N7#function" }, { "database": "UniProtKB", "id": "ARBA00037198", "url": "https://www.uniprot.org/uniprotkb/ARBA00037198#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZA83", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZA83", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12085", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12085", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11635", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11635", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11635:SF153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11635:SF153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24353:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24353:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16808", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16808", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T7N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZA83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTLRDLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEESLHQI", "length": 259, "header": "tr|A0AAF6ZA83-1|A0AAF6ZA83_BOVIN Isoform 1 of Cyclic nucleotide-binding domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6ZA83-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N7/entry", "sequence": { "sequence": "MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKSLFQTLHYST", "length": 192, "header": "tr|A0AAA9T7N7-1|A0AAF6ZA83_BOVIN Computationally mapped isoform of Cyclic nucleotide-binding domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6ZA83-1" }, "locus": { "chromosome": "26", "start_pos": 8313722, "end_pos": 6899622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107501.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107501.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094749.1" } ] } }, { "isoform_ac": "A0AAF6ZA83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83/entry", "sequence": { "sequence": "MGTLRDLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEESLHQI", "length": 259, "header": "tr|A0AAF6ZA83-1|A0AAF6ZA83_BOVIN Isoform 1 of Cyclic nucleotide-binding domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6ZA83-1" }, "locus": { "chromosome": "26", "start_pos": 8220419, "end_pos": 6899622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030539.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030539.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030518.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030518.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase complex", "id": "GO:0005952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005952", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "cAMP binding", "id": "GO:0030552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030552", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "cGMP-dependent protein kinase activity", "id": "GO:0004692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004692", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "calcium channel regulator activity", "id": "GO:0005246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005246", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "cGMP binding", "id": "GO:0030553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030553", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "relaxation of vascular associated smooth muscle", "id": "GO:0060087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060087", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "regulation of vascular permeability", "id": "GO:0043114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043114", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "collateral sprouting", "id": "GO:0048668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048668", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "receptor guanylyl cyclase signaling pathway", "id": "GO:0007168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007168", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "negative regulation of platelet aggregation", "id": "GO:0090331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090331", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904706", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell migration", "id": "GO:1904753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904753", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZA83", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZA83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZA83" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 118, "end_pos": 233, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9K7-1", "uniprot_ac": "A0AAF6Z9K7", "uniprot_id": "A0AAF6Z9K7_BOVIN", "mass": { "chemical_mass": 63920.0, "monoisotopic_mass": 63920.0 }, "refseq": {}, "gene_names": [ { "name": "IFNAR1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ] } ], "protein_names": [ { "name": "Interferon alpha/beta receptor 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7/entry#names_and_taxonomy" } ] }, { "name": "IFN-R-1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7/entry#names_and_taxonomy" } ] }, { "name": "IFN-alpha/beta receptor 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7/entry#names_and_taxonomy" } ] }, { "name": "Type I interferon receptor 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7#function" }, { "database": "UniProtKB", "id": "PIRNR016567", "url": "https://www.uniprot.org/uniprotkb/PIRNR016567#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFNAR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7", "locus": { "chromosome": "1", "start_pos": 2189896, "end_pos": 2218344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021819", "url": "https://www.ensembl.org/id/ENSBTAG00000021819" } ] } } ], "crossref": [ { "id": "A0AAF6Z9K7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9K7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016669", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016669", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01108", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01108", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T7Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9K7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TMLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSADYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFVPFLEAQIGPPDVHLEAEDKAIILSISPPGTKDSIMWAMDRSSFRYSVVIWKNSSSLEERTETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENIQINADNQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSRGIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENMSVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGSSFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVDEYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYSNEDENSGSKISEEFPQQDSV", "length": 561, "header": "tr|A0AAF6Z9K7-1|A0AAF6Z9K7_BOVIN Isoform 1 of Interferon alpha/beta receptor 1 OS=Bos taurus OX=9913 GN=IFNAR1 PE=3 SV=1 CANONICAL=A0AAF6Z9K7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Q4/entry", "sequence": { "sequence": "TMLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSADYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFVPFLEERHKVPSPENIQINADNQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSRGIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENMSVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGSSFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVDEYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYSNEDENSGSKISEEFPQQDSV", "length": 461, "header": "tr|A0AAA9T7Q4-1|A0AAF6Z9K7_BOVIN Computationally mapped isoform of Interferon alpha/beta receptor 1 OS=Bos taurus OX=9913 GN=IFNAR1 PE=3 SV=1 CANONICAL=A0AAF6Z9K7-1" }, "locus": { "chromosome": "1", "start_pos": 2218159, "end_pos": 2191321, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093354.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093354.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092807.1" } ] } }, { "isoform_ac": "A0AAF6Z9K7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7/entry", "sequence": { "sequence": "TMLALLGATTLMLVAGRWVLPAASGEANLKPENVEIHIIDDNFFLKWNSSSESVKNVTFSADYQILGTDNWKKLSGCQHITSTKCNFSSVELENVFEKIELRIRAEEGNNTSTWYEVEPFVPFLEAQIGPPDVHLEAEDKAIILSISPPGTKDSIMWAMDRSSFRYSVVIWKNSSSLEERTETVYPEDKIYKLSPEITYCLKVKAELRLQSRVGCYSPVYCINTTERHKVPSPENIQINADNQIYVLKWDYPYENATFQAQWLRAFFKKIPGNHSDKWKQIPNCENVTSTHCVFPREVSSRGIYYVRVRASNGNGTSFWSEEKEFNTEMKTIIFPPVISVKSVTDDSLHVSVGASEESENMSVNQLYPLIYEVIFWENTSNAERKVLEKRTNFIFPDLKPLTVYCVKARALIENDRRNKGSSFSDTVCEKTKPGNTSKTWLIVGTCTALFSIPVVIYVVSVFLRCVKYVFFPSSKPPSSVDEYFSDQPLRNLLLSTSEEQTERCFIIENASIITEIEETDEIDEVHKKYSSQTSQDSGNYSNEDENSGSKISEEFPQQDSV", "length": 561, "header": "tr|A0AAF6Z9K7-1|A0AAF6Z9K7_BOVIN Isoform 1 of Interferon alpha/beta receptor 1 OS=Bos taurus OX=9913 GN=IFNAR1 PE=3 SV=1 CANONICAL=A0AAF6Z9K7-1" }, "locus": { "chromosome": "1", "start_pos": 2218159, "end_pos": 2191321, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029080.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029080.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029080.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029080.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of metabolic process", "id": "GO:0009893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "cellular response to interferon-alpha", "id": "GO:0035457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035457", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "cellular response to interferon-beta", "id": "GO:0035458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "positive regulation of cellular respiration", "id": "GO:1901857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901857", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via JAK-STAT", "id": "GO:0007259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007259", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "cytokine binding", "id": "GO:0019955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019955", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "type I interferon receptor activity", "id": "GO:0004905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004905", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "JAK pathway signal transduction adaptor activity", "id": "GO:0008269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008269", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" }, { "name": "type I interferon binding", "id": "GO:0019962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019962", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9K7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z9K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9K7" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 232, "end_pos": 330, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 110, "end_pos": 112 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 223, "end_pos": 225 }, { "start_pos": 255, "end_pos": 257 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 314, "end_pos": 316 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 435, "end_pos": 437 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 509, "end_pos": 511 }, { "start_pos": 539, "end_pos": 541 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4R4-1", "uniprot_ac": "A0AAF6Z4R4", "uniprot_id": "A0AAF6Z4R4_BOVIN", "mass": { "chemical_mass": 36112.0, "monoisotopic_mass": 36112.0 }, "refseq": { "ac": "XP_005218104", "name": "cytosolic arginine sensor for mTORC1 subunit 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218104" }, "gene_names": [ { "name": "CASTOR1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ] }, { "name": "CASTOR1", "type": "synonym", "evidence": [ { "id": "XP_005218104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218104" } ] }, { "name": "GATSL3", "type": "synonym", "evidence": [ { "id": "XP_005218104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218104" } ] } ], "protein_names": [ { "name": "Cytosolic arginine sensor for mTORC1 subunit 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4/entry#names_and_taxonomy" } ] }, { "name": "GATS-like protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6Z4R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4/entry#names_and_taxonomy" } ] }, { "name": "cytosolic arginine sensor for mTORC1 subunit 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218104" } ] } ], "function": [ { "annotation": "Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4#function" }, { "database": "UniProtKB", "id": "ARBA00002751", "url": "https://www.uniprot.org/uniprotkb/ARBA00002751#function" }, { "database": "UniProtKB", "id": "A0AAA9T9I7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9I7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CASTOR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4", "locus": { "chromosome": "17", "start_pos": 69300857, "end_pos": 69305385, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018084", "url": "https://www.ensembl.org/id/ENSBTAG00000018084" } ] } } ], "crossref": [ { "id": "A0AAF6Z4R4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4R4", "database": "AlphaFoldDB", "categories": [] }, { "id": "506974", "url": "https://www.ncbi.nlm.nih.gov/gene/506974", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31131:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31131:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18700", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18700", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218104", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218104", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9I7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9I7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9I7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELHILEHRVRVLSLARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSPSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAREFDIYREVGGEPVPVARDDSSNGFPRAQHAGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSPPREAASGGPGSSSIAFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQDGLGS", "length": 330, "header": "tr|A0AAF6Z4R4-1|A0AAF6Z4R4_BOVIN Isoform 1 of Cytosolic arginine sensor for mTORC1 subunit 1 OS=Bos taurus OX=9913 GN=CASTOR1 PE=3 SV=1 CANONICAL=A0AAF6Z4R4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9I7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9I7/entry", "sequence": { "sequence": "MELHILEHRVRVLSLARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSPSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAREFDIYREVGGEPVPVARDDSSNGFPRAQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHRFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQDGLGS", "length": 291, "header": "tr|A0AAA9T9I7-1|A0AAF6Z4R4_BOVIN Computationally mapped isoform of Cytosolic arginine sensor for mTORC1 subunit 1 OS=Bos taurus OX=9913 GN=CASTOR1 PE=3 SV=1 CANONICAL=A0AAF6Z4R4-1" }, "locus": { "chromosome": "17", "start_pos": 69305246, "end_pos": 69301295, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107203.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107203.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093296.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093296.1" } ] } }, { "isoform_ac": "A0AAF6Z4R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4/entry", "sequence": { "sequence": "MELHILEHRVRVLSLARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSPSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAREFDIYREVGGEPVPVARDDSSNGFPRAQHAGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSPPREAASGGPGSSSIAFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQDGLGS", "length": 330, "header": "tr|A0AAF6Z4R4-1|A0AAF6Z4R4_BOVIN Isoform 1 of Cytosolic arginine sensor for mTORC1 subunit 1 OS=Bos taurus OX=9913 GN=CASTOR1 PE=3 SV=1 CANONICAL=A0AAF6Z4R4-1" }, "locus": { "chromosome": "17", "start_pos": 69305246, "end_pos": 69301295, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024074.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024074.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024074.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024074.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "GATOR2 complex", "id": "GO:0061700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061700", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "cellular response to L-arginine", "id": "GO:1903577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903577", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "arginine binding", "id": "GO:0034618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034618", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "molecular sensor activity", "id": "GO:0140299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140299", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z4R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" }, { "id": "PF13840", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13840" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CASTOR ACT", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 138, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z4R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" }, { "id": "PF18700", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18700" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CASTOR1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 69, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z4R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R4" }, { "id": "PF21389", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21389" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cytosolic arginine sensor for mTORC1 subunit 1/2 ACT-like", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 259, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZJL6-1", "uniprot_ac": "A0AAF6ZJL6", "uniprot_id": "A0AAF6ZJL6_BOVIN", "mass": { "chemical_mass": 37974.0, "monoisotopic_mass": 37974.0 }, "refseq": {}, "gene_names": [ { "name": "AHSA2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6" } ] } ], "protein_names": [ { "name": "Activator of HSP90 ATPase homolog 2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJL6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AHSA2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6", "locus": { "chromosome": "11", "start_pos": 59859806, "end_pos": 59837506, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006025", "url": "https://www.ensembl.org/id/ENSBTAG00000006025" } ] } } ], "crossref": [ { "id": "A0AAF6ZJL6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZJL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08892", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08892", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531017", "url": "https://www.ncbi.nlm.nih.gov/gene/531017", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531017", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531017", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13009", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13009:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13009:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095604", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJL6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKWGQGDPRWIVEEREDGTNVNNWHWTERDATSWSKGRLRELLVGITVENEAGRCEISELKQVEGEASCSSRKGKLIFFYEWNIKLGWKGIIRESGAKHKGLIEIPSLSEENEVDDTEVNVSKKKGDGDILKDLMKTAGTAKVREALGDYLKALKTEFTMGMILPTKAMAAQELTVERKLSENALQIQASSRVALGVRIPTVALHMTELFDTAIEQLYRIFTVKDLVQKFSKSPAVLEAEKGGKFQMFDGNITGEYTELLTNKKIVMKWRCRNWPEEHYAIVALNFVPTLQQTELQLDCKGVPVCEEENMKFCWQKQHFEEIKGLLQLTTLNG", "length": 334, "header": "tr|A0AAF6ZJL6-1|A0AAF6ZJL6_BOVIN Isoform 1 of Activator of HSP90 ATPase homolog 2 OS=Bos taurus OX=9913 GN=AHSA2 PE=3 SV=1 CANONICAL=A0AAF6ZJL6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAF6/entry", "sequence": { "sequence": "MAKWGQGDPRWIVEEREDGTNVNNWHWTERDATSWSKGRLRELLVGITVENEAGRCEISELKQVEGEASCSSRKGKLIFFYEWNIKLGWKVSAIHIGQLKTCARAVVLVNVSKKKGDGDILKDLMKTAGTAKVREALGDYLKALKTEFTMGMILPTKAMAAQELTVERKLSENALQASSRVALGVRIPTVALHMTELFDTAIEQLYRIFTVKDLVQKFSKSPAVLEAEKGGKFQMFDGNITGEYTELLTNKKIVMKWRCRNWPEEHYAIVALNFVPTLQQTELQLDCKGVPVCEEENMKFCWQKQHFEEIKGLLQLTTLNG", "length": 321, "header": "tr|A0AAA9TAF6-1|A0AAF6ZJL6_BOVIN Computationally mapped isoform of Activator of HSP90 ATPase homolog 2 OS=Bos taurus OX=9913 GN=AHSA2 PE=3 SV=1 CANONICAL=A0AAF6ZJL6-1" }, "locus": { "chromosome": "11", "start_pos": 59859680, "end_pos": 59837583, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115718.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115718.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092979.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092979.1" } ] } }, { "isoform_ac": "A0AAF6ZJL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6/entry", "sequence": { "sequence": "MAKWGQGDPRWIVEEREDGTNVNNWHWTERDATSWSKGRLRELLVGITVENEAGRCEISELKQVEGEASCSSRKGKLIFFYEWNIKLGWKGIIRESGAKHKGLIEIPSLSEENEVDDTEVNVSKKKGDGDILKDLMKTAGTAKVREALGDYLKALKTEFTMGMILPTKAMAAQELTVERKLSENALQIQASSRVALGVRIPTVALHMTELFDTAIEQLYRIFTVKDLVQKFSKSPAVLEAEKGGKFQMFDGNITGEYTELLTNKKIVMKWRCRNWPEEHYAIVALNFVPTLQQTELQLDCKGVPVCEEENMKFCWQKQHFEEIKGLLQLTTLNG", "length": 334, "header": "tr|A0AAF6ZJL6-1|A0AAF6ZJL6_BOVIN Isoform 1 of Activator of HSP90 ATPase homolog 2 OS=Bos taurus OX=9913 GN=AHSA2 PE=3 SV=1 CANONICAL=A0AAF6ZJL6-1" }, "locus": { "chromosome": "11", "start_pos": 59859680, "end_pos": 59837583, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055769.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055769.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050140.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050140.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531017", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531017", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJL6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6" } ], "pmid": "" }, { "name": "ATPase activator activity", "id": "GO:0001671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001671", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJL6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZJL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJL6" }, { "id": "SM01000", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01000" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Activator of Hsp90 ATPase AHSA1-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 163, "start_aa": "Glu", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 252, "end_pos": 254 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z2P7-1", "uniprot_ac": "A0AAF6Z2P7", "uniprot_id": "A0AAF6Z2P7_BOVIN", "mass": { "chemical_mass": 85718.0, "monoisotopic_mass": 85718.0 }, "refseq": { "ac": "XP_005217106", "name": "nucleolar complex protein 2 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217106" }, "gene_names": [ { "name": "NOC2L", "type": "recommended", "evidence": [ { "id": "A0AAF6Z2P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ] }, { "name": "NOC2L", "type": "synonym", "evidence": [ { "id": "XP_005217106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217106" } ] } ], "protein_names": [ { "name": "NOC2 like nucleolar associated transcriptional repressor", "type": "synonym", "evidence": [ { "id": "A0AAF6Z2P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7/entry#names_and_taxonomy" } ] }, { "name": "nucleolar complex protein 2 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217106" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOC2L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7", "locus": { "chromosome": "16", "start_pos": 51526316, "end_pos": 51514432, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016528", "url": "https://www.ensembl.org/id/ENSBTAG00000016528" } ] } } ], "crossref": [ { "id": "A0AAF6Z2P7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z2P7", "database": "AlphaFoldDB", "categories": [] }, { "id": "508638", "url": "https://www.ncbi.nlm.nih.gov/gene/508638", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12687", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12687", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12687:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12687:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03715", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03715", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAALSRKRRLEELTVDEFLASGFDSESESEPEGAPEAETQAVRAAAREPDGPGGSPLARLEDPHLLSRRKGGASEHKDQLSRLKDKDPEFYKFLQENDQSLLNFSDSDSSEDEEEQLHSLPNMLEEASEEEEEEDGVPRGPEGKRRDSVPVTLAMVEKWKQAAKQHLTPKLFHEVVQAFRAAVATTQGDEEGAETSKFQVTDSAVFNALVTFCIRDLFGCLQKLLFGKAPKDSSRVLQPSSSPLWAKLRLDVKAYLSSVIQLVACVAEATVAAAILQHVGSSVPYYLTFPKQCRMLLKRMVVLWSTGEETLRVLAFVVLIKVCRHKKDVFLSPVLKQMYITYVRNCKFTSPSTLPLINFMQRTLTELLALDTGVAYQHAFLYIRQLAIHLRNAMTTRRKETYQSVYNWQFVHCLYLWCRALSTICPSEALQPLIYPLSQVVIGCIKLVPTARFYPLRMHCVRALTLLSESTGTFIPVLPFILEIFQQVDFNRRPGRISSRPINFAVILKLSKVNLQEKAYRDGLVEQLYDLTLEYLHSQAHSIAFPELVLPAVLQLKSFLRECKVANYCRQVRQLLEKVQENAEHIRSVRQKVSFGVSDQRAVDAWEKRTREEGTPLTKYYSQWRKLRDREIQLEISGKERLEDLNFPEVKRRKVGDRKDEDRAEFKDLFDLESDDEDDAPDFTKRGMPGSPGAWQKVEEEDDDSSSSSGEEEVSKSEDGSPDTEAGLDPQELWQLAQGPEDELQDLQLSEED", "length": 754, "header": "tr|A0AAF6Z2P7-1|A0AAF6Z2P7_BOVIN Isoform 1 of NOC2 like nucleolar associated transcriptional repressor OS=Bos taurus OX=9913 GN=NOC2L PE=3 SV=1 CANONICAL=A0AAF6Z2P7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ3/entry", "sequence": { "sequence": "MARRRLEELTVDEFLASGFDSESESEPEGAPEAETQAVRAAAREPDGPGGSPLARLEDPHLLSRRKGGASEHKDQLSRLKDKDPEFYKFLQENDQSLLNFSDSDSSEDEEEQLHSLPNMLEEASEEEEEEDGVPRGPEGKRRDSVPVTLAMVEKWKQAAKHLTPKLFHEVVQAFRAAVATTQGDEEGAETSKFQVTDSAVFNALVTFCIRDLFGCLQKLLFGKAPKDSSRVLQPSSSPLWAKLRLDVKAYLSSVIQLVACVAEATVAAAILQHVGSSVPYYLTFPKQCRMLLKRMVVLWSTGEETLRVLAFVVLIKVCRHKKDVFLSPVLKQMYITYVRNCKFTSPSTLPLINFMQRTLTELLALDTGVAYQHAFLYIRQLAIHLRNAMTTRRKETYQSVYNWQFVHCLYLWCRALSTICPSEALQPLIYPLSQVVIGCIKLVPTARFYPLRMHCVRALTLLSESTGTFIPVLPFILEIFQQVDFNRRPGRISSRPINFAVILKLSKVNLQEKAYRDGLVEQLYDLTLEYLHSQAHSIAFPELVLPAVLQLKSFLRECKVANYCRQVRQLLEKVQENAEHIRSVRQKVSFGVSDQRAVDAWEKRTREEGTPLTKYYSQWRKLRDREIQLEISGKERLEDLNFPEVKRRKVGDRKDEDRAEFKDLFDLESDDEDDAPDFTKRGMPGSPGAWQKVEEEDDDSSSSSGEEEVSKSEDGSPDTEAGLDPQELWQLAQGPEDELQDLQLSEED", "length": 748, "header": "tr|A0AAA9TAJ3-1|A0AAF6Z2P7_BOVIN Computationally mapped isoform of NOC2 like nucleolar associated transcriptional repressor OS=Bos taurus OX=9913 GN=NOC2L PE=3 SV=1 CANONICAL=A0AAF6Z2P7-1" }, "locus": { "chromosome": "16", "start_pos": 51526130, "end_pos": 51514631, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119411.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119411.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093902.1" } ] } }, { "isoform_ac": "A0AAF6Z2P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7/entry", "sequence": { "sequence": "MAAALSRKRRLEELTVDEFLASGFDSESESEPEGAPEAETQAVRAAAREPDGPGGSPLARLEDPHLLSRRKGGASEHKDQLSRLKDKDPEFYKFLQENDQSLLNFSDSDSSEDEEEQLHSLPNMLEEASEEEEEEDGVPRGPEGKRRDSVPVTLAMVEKWKQAAKQHLTPKLFHEVVQAFRAAVATTQGDEEGAETSKFQVTDSAVFNALVTFCIRDLFGCLQKLLFGKAPKDSSRVLQPSSSPLWAKLRLDVKAYLSSVIQLVACVAEATVAAAILQHVGSSVPYYLTFPKQCRMLLKRMVVLWSTGEETLRVLAFVVLIKVCRHKKDVFLSPVLKQMYITYVRNCKFTSPSTLPLINFMQRTLTELLALDTGVAYQHAFLYIRQLAIHLRNAMTTRRKETYQSVYNWQFVHCLYLWCRALSTICPSEALQPLIYPLSQVVIGCIKLVPTARFYPLRMHCVRALTLLSESTGTFIPVLPFILEIFQQVDFNRRPGRISSRPINFAVILKLSKVNLQEKAYRDGLVEQLYDLTLEYLHSQAHSIAFPELVLPAVLQLKSFLRECKVANYCRQVRQLLEKVQENAEHIRSVRQKVSFGVSDQRAVDAWEKRTREEGTPLTKYYSQWRKLRDREIQLEISGKERLEDLNFPEVKRRKVGDRKDEDRAEFKDLFDLESDDEDDAPDFTKRGMPGSPGAWQKVEEEDDDSSSSSGEEEVSKSEDGSPDTEAGLDPQELWQLAQGPEDELQDLQLSEED", "length": 754, "header": "tr|A0AAF6Z2P7-1|A0AAF6Z2P7_BOVIN Isoform 1 of NOC2 like nucleolar associated transcriptional repressor OS=Bos taurus OX=9913 GN=NOC2L PE=3 SV=1 CANONICAL=A0AAF6Z2P7-1" }, "locus": { "chromosome": "16", "start_pos": 51526130, "end_pos": 51514474, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021980.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021980.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021980.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021980.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "transcription initiation-coupled chromatin remodeling", "id": "GO:0045815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "negative regulation of intrinsic apoptotic signaling pathway", "id": "GO:2001243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001243", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "negative regulation of B cell apoptotic process", "id": "GO:0002903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002903", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "nucleosome binding", "id": "GO:0031491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z2P7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2P7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZC08-1", "uniprot_ac": "A0AAF6ZC08", "uniprot_id": "A0AAF6ZC08_BOVIN", "mass": { "chemical_mass": 33725.0, "monoisotopic_mass": 33725.0 }, "refseq": {}, "gene_names": [ { "name": "C19H17orf78", "type": "recommended", "evidence": [ { "id": "A0AAF6ZC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08" } ] } ], "protein_names": [ { "name": "Chromosome 19 C17orf78 homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6ZC08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZC08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C19H17orf78", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08", "locus": { "chromosome": "19", "start_pos": 13705204, "end_pos": 13692001, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025242", "url": "https://www.ensembl.org/id/ENSBTAG00000025242" } ] } } ], "crossref": [ { "id": "A0AAF6ZC08", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZC08", "database": "AlphaFoldDB", "categories": [] }, { "id": "616575", "url": "https://www.ncbi.nlm.nih.gov/gene/616575", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR36870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36870:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36870:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15829", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15829", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TH26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZC08", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZC08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTILVFSLIITSYNVTKKELRDSSCQVEPLPDLFPKDVRSIRAELIREAQAEAKRPMFIQNQTVAILQCLGSGSKVKVNLVHSEKRQKVKHILKNLRVMTVPCRNSTAPPSCHLTPASKVQAGFLVTGKAFLPGVSQCKVYPVMGASSETYPSTTTSVTPGKKGEKTTKVDGFSSPLNQDTDENLEKRKKWSIVVKVLIAVTLFVSGIAITVFVIFEVPCPSRCQQVRELCQCQRLRRRPRKEDQQPGTAESQSDTQPKKESVFCWTRGSQFIKSQESCRDHRGPPDILLKSSAVPHTLEEG", "length": 303, "header": "tr|A0AAF6ZC08-1|A0AAF6ZC08_BOVIN Isoform 1 of Chromosome 19 C17orf78 homolog OS=Bos taurus OX=9913 GN=C19H17orf78 PE=4 SV=1 CANONICAL=A0AAF6ZC08-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TH26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH26/entry", "sequence": { "sequence": "MDTILVFSLIITSYNVTKKELRDSSCQVEPLPDLFPKDVRSIRAELIREAQAEAKRPMFIQNQTVAILQCLGSGSKVKVNLVHSEKRQKVKHILKNLRVMTVPCRNSTAPPSCHLTPASKVQAGFLVTGKESMSTSQRAMPVPAVTEKAKEGRPATWDS", "length": 159, "header": "tr|A0AAA9TH26-1|A0AAF6ZC08_BOVIN Computationally mapped isoform of Chromosome 19 C17orf78 homolog OS=Bos taurus OX=9913 GN=C19H17orf78 PE=4 SV=1 CANONICAL=A0AAF6ZC08-1" }, "locus": { "chromosome": "19", "start_pos": 13701526, "end_pos": 13692052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097442.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097442.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096353.1" } ] } }, { "isoform_ac": "A0AAF6ZC08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZC08/entry", "sequence": { "sequence": "MDTILVFSLIITSYNVTKKELRDSSCQVEPLPDLFPKDVRSIRAELIREAQAEAKRPMFIQNQTVAILQCLGSGSKVKVNLVHSEKRQKVKHILKNLRVMTVPCRNSTAPPSCHLTPASKVQAGFLVTGKAFLPGVSQCKVYPVMGASSETYPSTTTSVTPGKKGEKTTKVDGFSSPLNQDTDENLEKRKKWSIVVKVLIAVTLFVSGIAITVFVIFEVPCPSRCQQVRELCQCQRLRRRPRKEDQQPGTAESQSDTQPKKESVFCWTRGSQFIKSQESCRDHRGPPDILLKSSAVPHTLEEG", "length": 303, "header": "tr|A0AAF6ZC08-1|A0AAF6ZC08_BOVIN Isoform 1 of Chromosome 19 C17orf78 homolog OS=Bos taurus OX=9913 GN=C19H17orf78 PE=4 SV=1 CANONICAL=A0AAF6ZC08-1" }, "locus": { "chromosome": "19", "start_pos": 13704200, "end_pos": 13692052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035403.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035403.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035278.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035278.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 160, "start_aa": "Thr", "end_pos": 160, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr160", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 160 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZKD9-1", "uniprot_ac": "A0AAF6ZKD9", "uniprot_id": "A0AAF6ZKD9_BOVIN", "mass": { "chemical_mass": 73138.0, "monoisotopic_mass": 73138.0 }, "refseq": {}, "gene_names": [ { "name": "CRTC2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ] } ], "protein_names": [ { "name": "CREB regulated transcription coactivator 2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRTC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9", "locus": { "chromosome": "3", "start_pos": 16487194, "end_pos": 16477697, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017942", "url": "https://www.ensembl.org/id/ENSBTAG00000017942" } ] } } ], "crossref": [ { "id": "A0AAF6ZKD9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZKD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR024783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13589", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13589", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13589:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13589:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TJ29", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZKD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYARHISFTEGSPYSPAYLSPPPESSWRRTMPWGSFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPSPAAPSVLPSRRGGCLDGETDSKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPATVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGSSTSNLTHTMTHLGISGGLALGPGYDAPGLHSPLSHPSFQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHALPTTSLGHPSLSAPALSSSSSSSSASSPVLGAPAYPASAPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVALDTSKLPTDQRLPPYPYSPPSLVLPTQQPTPKPLQQPGLPSQACSVQPSGGQPPGRQLQYGTLYPPGPSGHGQQSYHRSMSDFSLGNLEQFNMENPSTSLALDPPGFSEGPGFLGGEGPVSGPQDPHALNHQNVTHCSRHGSGPNVILTGDASPGFSKEIAAALAGVPGFEVSAAGLGLGLGLEEELRMEPLGLEGLSMLSDPCALLPDPAVEDSFRSDRLQ", "length": 696, "header": "tr|A0AAF6ZKD9-1|A0AAF6ZKD9_BOVIN Isoform 1 of CREB regulated transcription coactivator 2 OS=Bos taurus OX=9913 GN=CRTC2 PE=3 SV=1 CANONICAL=A0AAF6ZKD9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TJ29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ29/entry", "sequence": { "sequence": "MATSGANGPGSATASASNPRKFSEKIALQKQRQASLSSPQPQLQGSHSHPSLPASSLARHALPTTSLGHPSLSAPALSSSSSSSSASSPVLGAPAYPASAPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVALDTSKLPTDQRLPPYPYSPPSLVLPTQQPTPKPLQQPGLPSQACSVQPSGGQPPGRQLQYGTLYPPGPSGHGQQSYHRSMSDFSLGNLEQFNMENPSTSLALDPPGFSEGPGFLGGEGPVSGPQDPHALNHQNVTHCSRHGSGPNVILTGDASPGFSKEIAAALAGVPGFEVSAAGLGLGLGLEEELRMEPLGLEGLSMLSDPCALLPDPAVEDSFRSDRLQ", "length": 373, "header": "tr|A0AAA9TJ29-1|A0AAF6ZKD9_BOVIN Computationally mapped isoform of CREB regulated transcription coactivator 2 OS=Bos taurus OX=9913 GN=CRTC2 PE=3 SV=1 CANONICAL=A0AAF6ZKD9-1" }, "locus": { "chromosome": "3", "start_pos": 16486776, "end_pos": 16477748, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105884.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105884.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096922.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096922.1" } ] } }, { "isoform_ac": "A0AAF6ZKD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9/entry", "sequence": { "sequence": "MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYARHISFTEGSPYSPAYLSPPPESSWRRTMPWGSFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPSPAAPSVLPSRRGGCLDGETDSKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPATVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGSSTSNLTHTMTHLGISGGLALGPGYDAPGLHSPLSHPSFQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHALPTTSLGHPSLSAPALSSSSSSSSASSPVLGAPAYPASAPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVALDTSKLPTDQRLPPYPYSPPSLVLPTQQPTPKPLQQPGLPSQACSVQPSGGQPPGRQLQYGTLYPPGPSGHGQQSYHRSMSDFSLGNLEQFNMENPSTSLALDPPGFSEGPGFLGGEGPVSGPQDPHALNHQNVTHCSRHGSGPNVILTGDASPGFSKEIAAALAGVPGFEVSAAGLGLGLGLEEELRMEPLGLEGLSMLSDPCALLPDPAVEDSFRSDRLQ", "length": 696, "header": "tr|A0AAF6ZKD9-1|A0AAF6ZKD9_BOVIN Isoform 1 of CREB regulated transcription coactivator 2 OS=Bos taurus OX=9913 GN=CRTC2 PE=3 SV=1 CANONICAL=A0AAF6ZKD9-1" }, "locus": { "chromosome": "3", "start_pos": 16486776, "end_pos": 16477748, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056382.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056382.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050880.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050880.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 292, "start_aa": "Thr", "end_pos": 292, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr292", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" }, { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" }, { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cAMP response element binding protein binding", "id": "GO:0008140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008140", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 607, "end_pos": 609, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" }, { "id": "PF12886", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12886" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transducer of regulated CREB activity C-terminal", "eco_id": "ECO_0000259", "start_pos": 618, "end_pos": 695, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" }, { "id": "PF12884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transducer of regulated CREB activity N-terminal", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 72, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKD9" }, { "id": "PF12885", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12885" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transducer of regulated CREB activity middle", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 324, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 292 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 607, "end_pos": 609 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z667-1", "uniprot_ac": "A0AAF6Z667", "uniprot_id": "A0AAF6Z667_BOVIN", "mass": { "chemical_mass": 20416.0, "monoisotopic_mass": 20416.0 }, "refseq": {}, "gene_names": [ { "name": "S100A4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ] } ], "protein_names": [ { "name": "Protein S100-A4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667/entry#names_and_taxonomy" } ] }, { "name": "Metastasin", "type": "synonym", "evidence": [ { "id": "A0AAF6Z667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein A4", "type": "synonym", "evidence": [ { "id": "A0AAF6Z667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TLR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLR8#function" }, { "database": "UniProtKB", "id": "ARBA00056127", "url": "https://www.uniprot.org/uniprotkb/ARBA00056127#function" }, { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100A4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667", "locus": { "chromosome": "3", "start_pos": 16826547, "end_pos": 16821848, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019203", "url": "https://www.ensembl.org/id/ENSBTAG00000019203" } ] } } ], "crossref": [ { "id": "A0AAF6Z667", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z667", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TLR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z667-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFVCACWGRKLAFQAGRVERGGGGPLCSPHQPTIGGLGPVLPHPLPWAGPGSGINRSDCWVLPILPLSPSSLPSTSSLLLLTAAMAYPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDETAFQKLMSNLDCNKDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK", "length": 185, "header": "tr|A0AAF6Z667-1|A0AAF6Z667_BOVIN Isoform 1 of Protein S100-A4 OS=Bos taurus OX=9913 GN=S100A4 PE=3 SV=1 CANONICAL=A0AAF6Z667-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TLR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLR8/entry", "sequence": { "sequence": "MASLLEQALATLVRTFQEYSQFSGNPLCQAKFKELLEKELPTWAPTTLRECDYKQFISVLDTNKDCQLLTAAMAYPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDETAFQKLMSNLDCNKDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK", "length": 173, "header": "tr|A0AAA9TLR8-1|A0AAF6Z667_BOVIN Computationally mapped isoform of Protein S100-A4 OS=Bos taurus OX=9913 GN=S100A4 PE=3 SV=1 CANONICAL=A0AAF6Z667-1" }, "locus": { "chromosome": "3", "start_pos": 16826410, "end_pos": 16821853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091217.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091217.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097885.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097885.1" } ] } }, { "isoform_ac": "A0AAF6Z667-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667/entry", "sequence": { "sequence": "MFVCACWGRKLAFQAGRVERGGGGPLCSPHQPTIGGLGPVLPHPLPWAGPGSGINRSDCWVLPILPLSPSSLPSTSSLLLLTAAMAYPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDETAFQKLMSNLDCNKDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK", "length": 185, "header": "tr|A0AAF6Z667-1|A0AAF6Z667_BOVIN Isoform 1 of Protein S100-A4 OS=Bos taurus OX=9913 GN=S100A4 PE=3 SV=1 CANONICAL=A0AAF6Z667-1" }, "locus": { "chromosome": "3", "start_pos": 16826410, "end_pos": 16824049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025561.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025561.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025561.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025561.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transition metal ion binding", "id": "GO:0046914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046914", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z667", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z667" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 134, "end_pos": 169, "start_aa": "Thr", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8U8-1", "uniprot_ac": "A0AAF6Z8U8", "uniprot_id": "A0AAF6Z8U8_BOVIN", "mass": { "chemical_mass": 48665.0, "monoisotopic_mass": 48665.0 }, "refseq": {}, "gene_names": [ { "name": "DAW1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8" } ] } ], "protein_names": [ { "name": "Dynein assembly factor with WD repeat domains 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. Facilitates the onset of robust cilia motility during development.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8#function" }, { "database": "UniProtKB", "id": "ARBA00055601", "url": "https://www.uniprot.org/uniprotkb/ARBA00055601#function" }, { "database": "UniProtKB", "id": "A0AAA9TPW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DAW1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8", "locus": { "chromosome": "2", "start_pos": 116028253, "end_pos": 115992675, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021327", "url": "https://www.ensembl.org/id/ENSBTAG00000021327" } ] } } ], "crossref": [ { "id": "A0AAF6Z8U8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8U8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19846", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19846", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19846:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19846:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22847", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22847", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22847:SF744", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22847:SF744", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TNX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAEAVRCLDVSMATKSVGWSSPSEKMKLKSLLLRYYPPGIMLEYEKSGQLKTKSIDLLDLDPSTDVSALVEEIQKAEPLITASRSDQVKLLIQRLQNKLGQHSNHKFYLFKVLRAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELHTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQSGEEVFTLTGHSAEIISLSFNTSGNRIITGSFDHTVTVWEADTGRKVYTLIGHCAEISSAVFNWDCSLILTGSMDKTCKLWDAVNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRECVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGDIIITGSKDNTCRIWR", "length": 441, "header": "tr|A0AAF6Z8U8-1|A0AAF6Z8U8_BOVIN Isoform 1 of Dynein assembly factor with WD repeat domains 1 OS=Bos taurus OX=9913 GN=DAW1 PE=3 SV=1 CANONICAL=A0AAF6Z8U8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TNX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNX2/entry", "sequence": { "sequence": "MKLKSLLLRYYPPGIMLEYEKSGQLKTKSIDLLDLDPSTDVSALVEEIQKAEPLITASRSDQVKLLIQRLQNKLGQHSNHKFYLFKVLRAHILPLTNVALNKSGSCDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQSGEEVFTLTGHSAEIISLSFNTSGNRIITGSFDHTVTVWEADTGRKVYTLIGHCAEISSAVFNWDCSLILTGSMDKTCKLWDAVNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRECVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGDIIITGSKDNTCRIWR", "length": 374, "header": "tr|A0AAA9TNX2-1|A0AAF6Z8U8_BOVIN Computationally mapped isoform of Dynein assembly factor with WD repeat domains 1 OS=Bos taurus OX=9913 GN=DAW1 PE=3 SV=1 CANONICAL=A0AAF6Z8U8-1" }, "locus": { "chromosome": "2", "start_pos": 116027874, "end_pos": 115992828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105104.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105104.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098759.1" } ] } }, { "isoform_ac": "A0AAA9TPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW0/entry", "sequence": { "sequence": "ARRRSRILRYLFYNIFVYFLGIMLEYEKSGQLKTKSIDLLDLDPSTDVSALVEEIQKAEPLITASRSDQVKLLIQRLQNKLGQHSNHKFYLFKVLRAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELHTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQSGEEVFTLTGHSAEIISLSFNTSGNRIITGSFDHTVTVWEADTGRKVYTLIGHCAEISSAVFNWDCSLILTGSMDKTCKLWDAVNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRECVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGDIIITGRGEIDLINSAFLSIGC", "length": 428, "header": "tr|A0AAA9TPW0-1|A0AAF6Z8U8_BOVIN Computationally mapped isoform of Dynein assembly factor with WD repeat domains 1 OS=Bos taurus OX=9913 GN=DAW1 PE=3 SV=1 CANONICAL=A0AAF6Z8U8-1" }, "locus": { "chromosome": "2", "start_pos": 116025621, "end_pos": 115997665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111607.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111607.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100429.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100429.1" } ] } }, { "isoform_ac": "A0AAF6Z8U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8/entry", "sequence": { "sequence": "MRAEAVRCLDVSMATKSVGWSSPSEKMKLKSLLLRYYPPGIMLEYEKSGQLKTKSIDLLDLDPSTDVSALVEEIQKAEPLITASRSDQVKLLIQRLQNKLGQHSNHKFYLFKVLRAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELHTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQSGEEVFTLTGHSAEIISLSFNTSGNRIITGSFDHTVTVWEADTGRKVYTLIGHCAEISSAVFNWDCSLILTGSMDKTCKLWDAVNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRECVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGDIIITGSKDNTCRIWR", "length": 441, "header": "tr|A0AAF6Z8U8-1|A0AAF6Z8U8_BOVIN Isoform 1 of Dynein assembly factor with WD repeat domains 1 OS=Bos taurus OX=9913 GN=DAW1 PE=3 SV=1 CANONICAL=A0AAF6Z8U8-1" }, "locus": { "chromosome": "2", "start_pos": 116027874, "end_pos": 115992750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028431.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028431.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028431.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028431.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "axonemal dynein complex assembly", "id": "GO:0070286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070286", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8U8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 254, "end_pos": 256 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z437-1", "uniprot_ac": "A0AAF6Z437", "uniprot_id": "A0AAF6Z437_BOVIN", "mass": { "chemical_mass": 38851.0, "monoisotopic_mass": 38851.0 }, "refseq": {}, "gene_names": [ { "name": "LYSMD2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437" } ] } ], "protein_names": [ { "name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z437", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYSMD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437", "locus": { "chromosome": "10", "start_pos": 58642428, "end_pos": 58628826, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017683", "url": "https://www.ensembl.org/id/ENSBTAG00000017683" } ] } } ], "crossref": [ { "id": "A0AAF6Z437", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z437", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00118", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00118", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR018392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20932:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20932:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01476", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01476", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TPA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z437", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z437-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESIKEQNKALVFCFGQSGALSARRGIPPRDRGRLWGPSGYTAGSLSALRLSHRGASRVGRVEPSGPRGSSRSSFRSPSCRCAWKGGRGGAGGHHGGPVSSHRGLQPAAPAERPFAAPVRRKRRWRRTRRRPFGELPDPAAAAGPMADSSPAPSLRAGGPREPRPSAPSPPPPHSRLGSEAEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVSMEQIKRANKLFTNDCIFLKKTLNIPVISEKPLLFNGLNSVDSPENETVDSFSHEEELVAAGEDVSPLSPQELDVQPMQPEEVSARDFLQRLDLQIKLSTQAAKKLKGESRDEEGLYTASLYHS", "length": 360, "header": "tr|A0AAF6Z437-1|A0AAF6Z437_BOVIN Isoform 1 of LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=LYSMD2 PE=4 SV=1 CANONICAL=A0AAF6Z437-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TPA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA5/entry", "sequence": { "sequence": "MADSSPAPSLRAGGPREPRPSAPSPPPPHSRLGSEAEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVSMEQIKRANKLFTNDCIFLKKTLNIPVISEKPLLFNGLNSVDSPENETVDSFSHEEELVAAGEDVSPLSPQELDVQPMQPEEVSARDFLQRLDLQIKLSTQAAKKLKGESRYLKSF", "length": 207, "header": "tr|A0AAA9TPA5-1|A0AAF6Z437_BOVIN Computationally mapped isoform of LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=LYSMD2 PE=4 SV=1 CANONICAL=A0AAF6Z437-1" }, "locus": { "chromosome": "10", "start_pos": 58641274, "end_pos": 58629460, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128637.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128637.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100225.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100225.1" } ] } }, { "isoform_ac": "A0AAF6Z437-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437/entry", "sequence": { "sequence": "MESIKEQNKALVFCFGQSGALSARRGIPPRDRGRLWGPSGYTAGSLSALRLSHRGASRVGRVEPSGPRGSSRSSFRSPSCRCAWKGGRGGAGGHHGGPVSSHRGLQPAAPAERPFAAPVRRKRRWRRTRRRPFGELPDPAAAAGPMADSSPAPSLRAGGPREPRPSAPSPPPPHSRLGSEAEEAELSLSLARTKTRSYGSTASVRAPLGAGVIERHVEHRVRAGDTLQGIALKYGVSMEQIKRANKLFTNDCIFLKKTLNIPVISEKPLLFNGLNSVDSPENETVDSFSHEEELVAAGEDVSPLSPQELDVQPMQPEEVSARDFLQRLDLQIKLSTQAAKKLKGESRDEEGLYTASLYHS", "length": 360, "header": "tr|A0AAF6Z437-1|A0AAF6Z437_BOVIN Isoform 1 of LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Bos taurus OX=9913 GN=LYSMD2 PE=4 SV=1 CANONICAL=A0AAF6Z437-1" }, "locus": { "chromosome": "10", "start_pos": 58641635, "end_pos": 58629025, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023518.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023518.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023518.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023518.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z437" }, { "id": "PS51782", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51782" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LysM", "eco_id": "ECO_0000259", "start_pos": 217, "end_pos": 261, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 282, "end_pos": 284 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZAT9-1", "uniprot_ac": "A0AAF6ZAT9", "uniprot_id": "A0AAF6ZAT9_BOVIN", "mass": { "chemical_mass": 43126.0, "monoisotopic_mass": 43126.0 }, "refseq": {}, "gene_names": [ { "name": "NIFK", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ] } ], "protein_names": [ { "name": "Nucleolar protein interacting with the FHA domain of MKI67", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIFK", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9", "locus": { "chromosome": "2", "start_pos": 73387424, "end_pos": 73398160, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019387", "url": "https://www.ensembl.org/id/ENSBTAG00000019387" } ] } } ], "crossref": [ { "id": "A0AAF6ZAT9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZAT9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12307", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12307", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46754", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46754", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12196", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12196", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TQG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEATLNVPDDTCQPRSPLSPFTALRHALCLAPALRCRPGSAPAPCTQAPPRSRAAGPALPSALGKQRVWRFRVYRVGLVGVRAGGMAAFGGPAKPLLSLNPQEDAKFKKEVAQVRRRATKQQEKQKPTPGVIYVGHLPPTLYETQIRAYFSQFGTVTRFRLSRSKKTGNSKGYGFVEFESEDVAKIAAETMNNYLFGERLLKCHFIPPEKVHEELFREWHMPFKRPSYPAVKRYNQNRSLVQKLRMEERFKKKEKLLRKRLAKKGIDYNFPSLVKVLHKNEENASNTGPQNSRKHQALRKKKKAASVTPETPEKAVDSQGPTPVCTPAFLEKRKSEVAKMNDDDKDNEIVFKQPVSGVKEETQETQSPASSKKKRRRKHNQ", "length": 381, "header": "tr|A0AAF6ZAT9-1|A0AAF6ZAT9_BOVIN Isoform 1 of Nucleolar protein interacting with the FHA domain of MKI67 OS=Bos taurus OX=9913 GN=NIFK PE=4 SV=1 CANONICAL=A0AAF6ZAT9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TQG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG7/entry", "sequence": { "sequence": "MPRPRATLSPRLRPRAVHPGSAPAPCTQAPPRSRAAGPALPSALGKQRVWRFRVYRVGLVGVRAGGMAAFGGPAKPLLSLNPQEDAKFKKEVAQVRRRATKQQEKQKPTPGVIYVGHLPPTLYETQIRAYFSQFGTVTRFRLSRSKKTGNSKGYGFVEFESEDVAKIAAETMNNYLFGERLLKCHFIPPEKVHEELFREWHMPFKRPSYPAVKRYNQNRSLVQKLRMEERFKKKEKLLRKRLAKKGIDYNFPSLVKVLHKNEENASNTGPQNSRKHQALRKKKKAASVTPETPEKAVDSQGPTPVCTPAFLEKRKSEVAKMNDDDKDNEIVFKQPVSGVKEETQETQSPASSKKKRRRKHNQ", "length": 362, "header": "tr|A0AAA9TQG7-1|A0AAF6ZAT9_BOVIN Computationally mapped isoform of Nucleolar protein interacting with the FHA domain of MKI67 OS=Bos taurus OX=9913 GN=NIFK PE=4 SV=1 CANONICAL=A0AAF6ZAT9-1" }, "locus": { "chromosome": "2", "start_pos": 73398039, "end_pos": 73388106, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100613.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100613.1" } ] } }, { "isoform_ac": "A0AAF6ZAT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9/entry", "sequence": { "sequence": "MEATLNVPDDTCQPRSPLSPFTALRHALCLAPALRCRPGSAPAPCTQAPPRSRAAGPALPSALGKQRVWRFRVYRVGLVGVRAGGMAAFGGPAKPLLSLNPQEDAKFKKEVAQVRRRATKQQEKQKPTPGVIYVGHLPPTLYETQIRAYFSQFGTVTRFRLSRSKKTGNSKGYGFVEFESEDVAKIAAETMNNYLFGERLLKCHFIPPEKVHEELFREWHMPFKRPSYPAVKRYNQNRSLVQKLRMEERFKKKEKLLRKRLAKKGIDYNFPSLVKVLHKNEENASNTGPQNSRKHQALRKKKKAASVTPETPEKAVDSQGPTPVCTPAFLEKRKSEVAKMNDDDKDNEIVFKQPVSGVKEETQETQSPASSKKKRRRKHNQ", "length": 381, "header": "tr|A0AAF6ZAT9-1|A0AAF6ZAT9_BOVIN Isoform 1 of Nucleolar protein interacting with the FHA domain of MKI67 OS=Bos taurus OX=9913 GN=NIFK PE=4 SV=1 CANONICAL=A0AAF6ZAT9-1" }, "locus": { "chromosome": "2", "start_pos": 73398122, "end_pos": 73388106, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031564.4", "url": "https://www.ensembl.org/id/ENSBTAT00000031564.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031516.3", "url": "https://www.ensembl.org/id/ENSBTAP00000031516.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 128, "start_aa": "Thr", "end_pos": 128, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr128", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 322, "start_aa": "Thr", "end_pos": 322, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr322", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ], "pmid": "" }, { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZAT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAT9" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 208, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 128, 322 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 237, "end_pos": 239 }, { "start_pos": 283, "end_pos": 285 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z6D2-1", "uniprot_ac": "A0AAF6Z6D2", "uniprot_id": "A0AAF6Z6D2_BOVIN", "mass": { "chemical_mass": 20276.0, "monoisotopic_mass": 20276.0 }, "refseq": {}, "gene_names": [ { "name": "NDUFA11", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2/entry#names_and_taxonomy" } ] }, { "name": "Complex I-B14.7", "type": "synonym", "evidence": [ { "id": "A0AAF6Z6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2/entry#names_and_taxonomy" } ] }, { "name": "NADH-ubiquinone oxidoreductase subunit B14.7", "type": "synonym", "evidence": [ { "id": "A0AAF6Z6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6D2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFA11", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2", "locus": { "chromosome": "7", "start_pos": 18479240, "end_pos": 18472979, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019025", "url": "https://www.ensembl.org/id/ENSBTAG00000019025" } ] } } ], "crossref": [ { "id": "A0AAF6Z6D2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z6D2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR039205", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039205", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21382:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21382:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TVM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6D2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRTDSLEKTLMLGKIGGGCARRPGSLARVSGVRPWPQEQPGGKVQDQGCAVMAKTVLRQYWDIPEGTECHRKTYATTSIGGAAGLVVSAYSVALKTPTSFLEGVARTGRYTFTAAAIGAIFGLTSCISAQVREKPDDPLNYLIGGCAGGLILGARTRSYGIGAAACAYMGLTAALVKMGQLEGWQVFAEPKV", "length": 193, "header": "tr|A0AAF6Z6D2-1|A0AAF6Z6D2_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 OS=Bos taurus OX=9913 GN=NDUFA11 PE=3 SV=1 CANONICAL=A0AAF6Z6D2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TVM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVM0/entry", "sequence": { "sequence": "MAKTVLRQYWDIPEGTECHRKTYATTSIGGAAGLVVSAYSVALKTPTSFLEGVARTGRYTFTAAAIGAIFGLTSCISAQVREKPDDPLNYLIGGCAGGLILGARKNTGSLPVRGSSRGWLGAADTQGPTGKQLSPSPPSRWGH", "length": 143, "header": "tr|A0AAA9TVM0-1|A0AAF6Z6D2_BOVIN Computationally mapped isoform of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 OS=Bos taurus OX=9913 GN=NDUFA11 PE=3 SV=1 CANONICAL=A0AAF6Z6D2-1" }, "locus": { "chromosome": "7", "start_pos": 18478236, "end_pos": 18474133, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091777.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091777.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102664.1" } ] } }, { "isoform_ac": "A0AAF6Z6D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2/entry", "sequence": { "sequence": "MRRTDSLEKTLMLGKIGGGCARRPGSLARVSGVRPWPQEQPGGKVQDQGCAVMAKTVLRQYWDIPEGTECHRKTYATTSIGGAAGLVVSAYSVALKTPTSFLEGVARTGRYTFTAAAIGAIFGLTSCISAQVREKPDDPLNYLIGGCAGGLILGARTRSYGIGAAACAYMGLTAALVKMGQLEGWQVFAEPKV", "length": 193, "header": "tr|A0AAF6Z6D2-1|A0AAF6Z6D2_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 OS=Bos taurus OX=9913 GN=NDUFA11 PE=3 SV=1 CANONICAL=A0AAF6Z6D2-1" }, "locus": { "chromosome": "7", "start_pos": 18479047, "end_pos": 18473097, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025322.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025322.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025322.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025322.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6D2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2" } ], "pmid": "" }, { "name": "respiratory chain complex I", "id": "GO:0045271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045271", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6D2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6D2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6D2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZLE3-1", "uniprot_ac": "A0AAF6ZLE3", "uniprot_id": "A0AAF6ZLE3_BOVIN", "mass": { "chemical_mass": 25654.0, "monoisotopic_mass": 25654.0 }, "refseq": {}, "gene_names": [ { "name": "GPX3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ] } ], "protein_names": [ { "name": "Glutathione peroxidase", "type": "recommended", "evidence": [ { "id": "A0AAF6ZLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3", "locus": { "chromosome": "7", "start_pos": 62292964, "end_pos": 62284773, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043553", "url": "https://www.ensembl.org/id/ENSBTAG00000043553" } ] } } ], "crossref": [ { "id": "A0AAF6ZLE3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZLE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16833", "url": "https://www.rhea-db.org/rhea/16833", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZLE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARLFRASCLLSLLLAGFIPPSQGQEKSKTDCHAGVGGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVGYLHLCSLPVPELNALQEELEPFGLVILGFPCNQFGKQEPGENSEILATLKYVRPGGGFTPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGSPDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWYHRTTVNSVKMDILTYMRRRAVWEAKGK", "length": 226, "header": "tr|A0AAF6ZLE3-1|A0AAF6ZLE3_BOVIN Isoform 1 of Glutathione peroxidase OS=Bos taurus OX=9913 GN=GPX3 PE=3 SV=1 CANONICAL=A0AAF6ZLE3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZLE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3/entry", "sequence": { "sequence": "MARLFRASCLLSLLLAGFIPPSQGQEKSKTDCHAGVGGTIYEYGALTIDGEEYIPFKQYAGKYILFVNVGYLHLCSLPVPELNALQEELEPFGLVILGFPCNQFGKQEPGENSEILATLKYVRPGGGFTPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGSPDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWYHRTTVNSVKMDILTYMRRRAVWEAKGK", "length": 226, "header": "tr|A0AAF6ZLE3-1|A0AAF6ZLE3_BOVIN Isoform 1 of Glutathione peroxidase OS=Bos taurus OX=9913 GN=GPX3 PE=3 SV=1 CANONICAL=A0AAF6ZLE3-1" }, "locus": { "chromosome": "7", "start_pos": 62292141, "end_pos": 62284859, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060554.5", "url": "https://www.ensembl.org/id/ENSBTAT00000060554.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053146.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053146.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ], "pmid": "" }, { "name": "glutathione peroxidase activity", "id": "GO:0004602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004602", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ], "pmid": "" }, { "name": "selenium binding", "id": "GO:0008430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008430", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16833", "name": "", "equation": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1", "P37141-1", "F1N076-1", "A0A3Q1M314-1" ], "evidence": [ { "id": "16833", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16833" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M314", "gene_name": "HEPH", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] } ] }, { "uniprot_ac": "F1N076", "gene_name": "CP", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] } ] }, { "uniprot_ac": "P00435", "gene_name": "GPX1", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] } ] }, { "uniprot_ac": "P37141", "gene_name": "GPX3", "activity": [ { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P37141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P37141" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P37141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P37141" } ] } ] }, { "uniprot_ac": "Q9N2J2", "gene_name": "GPX4", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] }, { "ec_number": "1.11.1.12", "activity": "", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZBW5-1", "uniprot_ac": "A0AAF6ZBW5", "uniprot_id": "A0AAF6ZBW5_BOVIN", "mass": { "chemical_mass": 28564.0, "monoisotopic_mass": 28564.0 }, "refseq": {}, "gene_names": [ { "name": "SLC25A11", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5" } ] } ], "protein_names": [ { "name": "Mitochondrial 2-oxoglutarate/malate carrier protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 25 member 11", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Does not transport glutathione. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5#function" }, { "database": "UniProtKB", "id": "ARBA00094343", "url": "https://www.uniprot.org/uniprotkb/ARBA00094343#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC25A11", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5", "locus": { "chromosome": "19", "start_pos": 26458255, "end_pos": 26455376, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004910", "url": "https://www.ensembl.org/id/ENSBTAG00000004910" } ] } } ], "crossref": [ { "id": "A0AAF6ZBW5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZBW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45618", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45618", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "71587", "url": "https://www.rhea-db.org/rhea/71587", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71591", "url": "https://www.rhea-db.org/rhea/71591", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71595", "url": "https://www.rhea-db.org/rhea/71595", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71599", "url": "https://www.rhea-db.org/rhea/71599", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71603", "url": "https://www.rhea-db.org/rhea/71603", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATASPGASGMDGKPRTSPKSVKFLFGGLAGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLVKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG", "length": 263, "header": "tr|A0AAF6ZBW5-1|A0AAF6ZBW5_BOVIN Isoform 1 of Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus OX=9913 GN=SLC25A11 PE=3 SV=1 CANONICAL=A0AAF6ZBW5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZBW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5/entry", "sequence": { "sequence": "MAATASPGASGMDGKPRTSPKSVKFLFGGLAGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLVKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG", "length": 263, "header": "tr|A0AAF6ZBW5-1|A0AAF6ZBW5_BOVIN Isoform 1 of Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus OX=9913 GN=SLC25A11 PE=3 SV=1 CANONICAL=A0AAF6ZBW5-1" }, "locus": { "chromosome": "19", "start_pos": 26457790, "end_pos": 26455575, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035225.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035225.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035103.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035103.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "alpha-ketoglutarate transmembrane transporter activity", "id": "GO:0015139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5" } ], "pmid": "" }, { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBW5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "71587", "name": "", "equation": "(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71587", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71587" } ] }, { "id": "71591", "name": "", "equation": "malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71591", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71591" } ] }, { "id": "71595", "name": "", "equation": "succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71595", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71595" } ] }, { "id": "71599", "name": "", "equation": "maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71599", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71599" } ] }, { "id": "71603", "name": "", "equation": "oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71603", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71603" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z676-1", "uniprot_ac": "A0AAF6Z676", "uniprot_id": "A0AAF6Z676_BOVIN", "mass": { "chemical_mass": 58275.0, "monoisotopic_mass": 58275.0 }, "refseq": { "ac": "XP_005222837", "name": "inosine-5'-monophosphate dehydrogenase 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222837" }, "gene_names": [ { "name": "IMPDH2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ] }, { "name": "IMPDH2", "type": "synonym", "evidence": [ { "id": "XP_005222837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222837" } ] }, { "name": "IMPDH", "type": "synonym", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ] } ], "protein_names": [ { "name": "Inosine-5'-monophosphate dehydrogenase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.205", "type": "synonym", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676/entry#names_and_taxonomy" } ] }, { "name": "IMP dehydrogenase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676/entry#names_and_taxonomy" } ] }, { "name": "IMPDH", "type": "synonym", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676/entry#names_and_taxonomy" } ] }, { "name": "IMPD", "type": "synonym", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676/entry#names_and_taxonomy" } ] }, { "name": "inosine-5'-monophosphate dehydrogenase 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005222837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222837" } ] } ], "function": [ { "annotation": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RUS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUS2#function" }, { "database": "HAMAP", "id": "MF_03156", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "database": "UniProtKB", "id": "ARBA00046101", "url": "https://www.uniprot.org/uniprotkb/ARBA00046101#function" }, { "database": "UniProtKB", "id": "A0AAA9T7T4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7T4#function" }, { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IMPDH2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676", "locus": { "chromosome": "22", "start_pos": 50967685, "end_pos": 50962699, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031837", "url": "https://www.ensembl.org/id/ENSBTAG00000031837" } ] } } ], "crossref": [ { "id": "A0AAF6Z676", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z676", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00381", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00381", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511969", "url": "https://www.ncbi.nlm.nih.gov/gene/511969", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11911:SF121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11911:SF121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00478", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00478", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005222837", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222837", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11708", "url": "https://www.rhea-db.org/rhea/11708", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RUS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7T4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7T4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z676-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEAAPKIPPDIKSHSPKCPSTVTGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF", "length": 538, "header": "tr|A0AAF6Z676-1|A0AAF6Z676_BOVIN Isoform 1 of Inosine-5'-monophosphate dehydrogenase OS=Bos taurus OX=9913 GN=IMPDH2 PE=3 SV=1 CANONICAL=A0AAF6Z676-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUS2/entry", "sequence": { "sequence": "MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMAKYEQGFITDPVVLSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEAAPKIPPDIKSHSPKCPSTVTGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF", "length": 513, "header": "tr|A0AAA9RUS2-1|A0AAF6Z676_BOVIN Computationally mapped isoform of Inosine-5'-monophosphate dehydrogenase OS=Bos taurus OX=9913 GN=IMPDH2 PE=3 SV=1 CANONICAL=A0AAF6Z676-1" }, "locus": { "chromosome": "22", "start_pos": 50967636, "end_pos": 50962913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125863.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125863.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074695.1" } ] } }, { "isoform_ac": "A0AAA9T7T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7T4/entry", "sequence": { "sequence": "MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHS", "length": 508, "header": "tr|A0AAA9T7T4-1|A0AAF6Z676_BOVIN Computationally mapped isoform of Inosine-5'-monophosphate dehydrogenase OS=Bos taurus OX=9913 GN=IMPDH2 PE=3 SV=2 CANONICAL=A0AAF6Z676-1" }, "locus": { "chromosome": "22", "start_pos": 50967517, "end_pos": 50962913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132576.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132576.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093997.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093997.2" } ] } }, { "isoform_ac": "A0AAF6Z676-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676/entry", "sequence": { "sequence": "MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPRDRVRDVFEAKARHGFCGIPITDTGRMGSHLVGIISSRDIDFLKEEEHDRLLGEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLSQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSIQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEAAPKIPPDIKSHSPKCPSTVTGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF", "length": 538, "header": "tr|A0AAF6Z676-1|A0AAF6Z676_BOVIN Isoform 1 of Inosine-5'-monophosphate dehydrogenase OS=Bos taurus OX=9913 GN=IMPDH2 PE=3 SV=1 CANONICAL=A0AAF6Z676-1" }, "locus": { "chromosome": "22", "start_pos": 50967636, "end_pos": 50962913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025179.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025179.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025179.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025179.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" }, { "name": "IMP dehydrogenase activity", "id": "GO:0003938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003938", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "GMP biosynthetic process", "id": "GO:0006177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006177", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" }, { "name": "circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" }, { "name": "GTP biosynthetic process", "id": "GO:0006183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006183", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" }, { "name": "'de novo' XMP biosynthetic process", "id": "GO:0097294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097294", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z676", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11708", "name": "", "equation": "IMP + NAD(+) + H2O = XMP + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0JNA3-1", "A0AAF6Z676-1", "Q3SWY3-1", "A0AAA9SH20-1" ], "evidence": [ { "id": "11708", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11708" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SH20", "gene_name": "GMPR2", "activity": [ { "ec_number": "1.7.1.7", "activity": "IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+).", "evidence": [ { "id": "A0AAA9SH20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH20" } ] }, { "ec_number": "1.7.1.7", "activity": "", "evidence": [ { "id": "A0AAA9SH20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH20" } ] } ] }, { "uniprot_ac": "A0AAF6Z676", "gene_name": "IMPDH2", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "Q3SWY3", "gene_name": "IMPDH2", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" }, { "id": "PS51371", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51371" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBS", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 173, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "id": "PIRSR000130-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000130-4" } ], "binding_site_uniprot": 301, "amino_acid": "Gly", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "in other chain;ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 301, "end_pos": 301, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "id": "PIRSR000130-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000130-4" } ], "binding_site_uniprot": 303, "amino_acid": "Asn", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "in other chain;ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 303, "end_pos": 303, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "id": "PIRSR000130-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000130-4" } ], "binding_site_uniprot": 306, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "in other chain;ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 306, "end_pos": 306, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" }, { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "id": "PIRSR000130-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000130-4" } ], "binding_site_uniprot": 326, "amino_acid": "Gly", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "in other chain;ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 326, "end_pos": 326, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" }, { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "id": "PIRSR000130-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000130-4" } ], "binding_site_uniprot": 328, "amino_acid": "Gly", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "in other chain;ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 328, "end_pos": 328, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" }, { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" }, { "id": "PIRSR000130-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000130-4" } ], "binding_site_uniprot": 331, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "in other chain;ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 331, "end_pos": 331, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" } ], "binding_site_uniprot": 495, "amino_acid": "Ile", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 495, "end_pos": 495, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" } ], "binding_site_uniprot": 496, "amino_acid": "Gly", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 496, "end_pos": 496, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z676" }, { "id": "MF_03156", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03156" } ], "binding_site_uniprot": 520, "amino_acid": "Ser", "chebi_lig_id": "CHEBI:29103", "ligand": "K(+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared between two tetrameric partners", "eco_id": "ECO_0000256", "start_pos": 520, "end_pos": 520, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.205", "ec_name": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "1.1.1.205", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205" }, { "id": "1.1.1.205", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.205" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZL21-1", "uniprot_ac": "A0AAF6ZL21", "uniprot_id": "A0AAF6ZL21_BOVIN", "mass": { "chemical_mass": 37444.0, "monoisotopic_mass": 37444.0 }, "refseq": {}, "gene_names": [ { "name": "TOMM40L", "type": "recommended", "evidence": [ { "id": "A0AAF6ZL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21" } ] } ], "protein_names": [ { "name": "Translocase of outer mitochondrial membrane 40 like", "type": "synonym", "evidence": [ { "id": "A0AAF6ZL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOMM40L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21", "locus": { "chromosome": "3", "start_pos": 8275799, "end_pos": 8280293, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009213", "url": "https://www.ensembl.org/id/ENSBTAG00000009213" } ] } } ], "crossref": [ { "id": "A0AAF6ZL21", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZL21", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07305", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07305", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR023614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10802", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10802", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01459", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01459", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TZI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZL21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZL21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTLGLAPMGALPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTEGVLRTVKEILRLDWGREVPLCSVLLTVDTLQQVFPTVVGDMDSGGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIVVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 340, "header": "tr|A0AAF6ZL21-1|A0AAF6ZL21_BOVIN Isoform 1 of Translocase of outer mitochondrial membrane 40 like OS=Bos taurus OX=9913 GN=TOMM40L PE=3 SV=1 CANONICAL=A0AAF6ZL21-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TZI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI6/entry", "sequence": { "sequence": "MGNTLGLAPMGALPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTETQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIVVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 274, "header": "tr|A0AAA9TZI6-1|A0AAF6ZL21_BOVIN Computationally mapped isoform of Translocase of outer mitochondrial membrane 40 like OS=Bos taurus OX=9913 GN=TOMM40L PE=3 SV=1 CANONICAL=A0AAF6ZL21-1" }, "locus": { "chromosome": "3", "start_pos": 8279826, "end_pos": 8277252, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102142.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102142.1" } ] } }, { "isoform_ac": "A0AAF6ZL21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21/entry", "sequence": { "sequence": "MGNTLGLAPMGALPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTEGVLRTVKEILRLDWGREVPLCSVLLTVDTLQQVFPTVVGDMDSGGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIVVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 340, "header": "tr|A0AAF6ZL21-1|A0AAF6ZL21_BOVIN Isoform 1 of Translocase of outer mitochondrial membrane 40 like OS=Bos taurus OX=9913 GN=TOMM40L PE=3 SV=1 CANONICAL=A0AAF6ZL21-1" }, "locus": { "chromosome": "3", "start_pos": 8279826, "end_pos": 8277252, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054884.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054884.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052024.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052024.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL21", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AAJ5-1", "uniprot_ac": "A0AAF7AAJ5", "uniprot_id": "A0AAF7AAJ5_BOVIN", "mass": { "chemical_mass": 45895.0, "monoisotopic_mass": 45895.0 }, "refseq": { "ac": "XP_005201561", "name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201561" }, "gene_names": [ { "name": "BDH1", "type": "recommended", "evidence": [ { "id": "A0AAF7AAJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ] }, { "name": "BDH1", "type": "synonym", "evidence": [ { "id": "XP_005201561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201561" } ] } ], "protein_names": [ { "name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF7AAJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.30", "type": "synonym", "evidence": [ { "id": "A0AAF7AAJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5/entry#names_and_taxonomy" } ] }, { "name": "3-hydroxybutyrate dehydrogenase", "type": "synonym", "evidence": [ { "id": "A0AAF7AAJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5/entry#names_and_taxonomy" } ] }, { "name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201561" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AAJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5", "locus": { "chromosome": "1", "start_pos": 71964668, "end_pos": 72000872, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000448", "url": "https://www.ensembl.org/id/ENSBTAG00000000448" } ] } } ], "crossref": [ { "id": "A0AAF7AAJ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AAJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09805", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09805", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534090", "url": "https://www.ncbi.nlm.nih.gov/gene/534090", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43313", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43313", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43313:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43313:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005201561", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20521", "url": "https://www.rhea-db.org/rhea/20521", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YGM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAVPGAPGQRRRRGAERSPPWQRPPSGSAPRSPTAEPLSVGAPRQLRVEAAGVRAEPTRRSLTILPFVATMLTARLSRPLSQLPRKTLNFSDRENGTRGSLLLYSAPFVPVGRRTYAASVDPVGSKAVLITGCDSGFGFSLAKHLHSEGFLVFAGCLMKDKGSDGVKELDSMKSDRLRTVQLNVCKSEEVDKAAEVIRSSLEDPEKGLWGLVNNAGISTFGDVEFTSMETYKEVAEVNLWGTVRVTKAFLPLIRRAKGRVVNISSMMGRMANVARSPYCITKFGVEAFSDCLRYEMHPLGVKVSVVEPGNFIAATSLYGGTERIQAIANKMWEELPEVVRQDYGRKYFDEKVARMESYCTSGSTDTSPVIKAVTHALTATTPYTRYHPMDYYWWLRMQIMTHFPGAISDRIYIH", "length": 415, "header": "tr|A0AAF7AAJ5-1|A0AAF7AAJ5_BOVIN Isoform 1 of D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=BDH1 PE=3 SV=1 CANONICAL=A0AAF7AAJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YGM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGM0/entry", "sequence": { "sequence": "MVSTPQRGSACALEAPASYNHFVSKPKEPTRRSLTILPFVATMLTARLSRPLSQLPRKTLNFSDRENGTRGSLLLYSAPFVPVGRRTYAASVDPVGSKAVLITGCDSGFGFSLAKHLHSEGFLVFAGCLMKDKGSDGVKELDSMKSDRLRTVQLNVCKSEEVDKAAEVIRSSLEDPEKGLWGLVNNAGISTFGDVEFTSMETYKEVAEVNLWGTVRVTKAFLPLIRRAKGRVVNISSMMGRMANVARSPYCITKFGVEAFSDCLRYEMHPLGVKVSVVEPGNFIAATSLYGGTERIQAIANKMWEELPEVVRQDYGRKYFDEKVARMESYCTSGSTDTSPVIKAVTHALTATTPYTRYHPMDYYWWLRMQIMTHFPGAISDRIYIH", "length": 386, "header": "tr|A0AAF6YGM0-1|A0AAF7AAJ5_BOVIN Computationally mapped isoform of D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=BDH1 PE=3 SV=1 CANONICAL=A0AAF7AAJ5-1" }, "locus": { "chromosome": "1", "start_pos": 71996004, "end_pos": 71965027, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000573.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000573.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000573.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000573.4" } ] } }, { "isoform_ac": "A0AAF7AAJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5/entry", "sequence": { "sequence": "MGAVPGAPGQRRRRGAERSPPWQRPPSGSAPRSPTAEPLSVGAPRQLRVEAAGVRAEPTRRSLTILPFVATMLTARLSRPLSQLPRKTLNFSDRENGTRGSLLLYSAPFVPVGRRTYAASVDPVGSKAVLITGCDSGFGFSLAKHLHSEGFLVFAGCLMKDKGSDGVKELDSMKSDRLRTVQLNVCKSEEVDKAAEVIRSSLEDPEKGLWGLVNNAGISTFGDVEFTSMETYKEVAEVNLWGTVRVTKAFLPLIRRAKGRVVNISSMMGRMANVARSPYCITKFGVEAFSDCLRYEMHPLGVKVSVVEPGNFIAATSLYGGTERIQAIANKMWEELPEVVRQDYGRKYFDEKVARMESYCTSGSTDTSPVIKAVTHALTATTPYTRYHPMDYYWWLRMQIMTHFPGAISDRIYIH", "length": 415, "header": "tr|A0AAF7AAJ5-1|A0AAF7AAJ5_BOVIN Isoform 1 of D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=BDH1 PE=3 SV=1 CANONICAL=A0AAF7AAJ5-1" }, "locus": { "chromosome": "1", "start_pos": 72000673, "end_pos": 71965027, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082799.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082799.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065955.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065955.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AAJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AAJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AAJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "3-hydroxybutyrate dehydrogenase activity", "id": "GO:0003858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003858", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AAJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20521", "name": "", "equation": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF7AAJ5-1", "F1MLA4-1", "Q02337-1", "Q3T046-1" ], "evidence": [ { "id": "20521", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20521" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF7AAJ5", "gene_name": "BDH1", "activity": [ { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "A0AAF7AAJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ] }, { "ec_number": "1.1.1.30", "activity": "", "evidence": [ { "id": "A0AAF7AAJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAJ5" } ] } ] }, { "uniprot_ac": "F1MLA4", "gene_name": "BDH2", "activity": [ { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "F1MLA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLA4" } ] }, { "ec_number": "1.1.1.104", "activity": "cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + NADH + H(+).", "evidence": [ { "id": "F1MLA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLA4" } ] }, { "ec_number": "1.1.1.104", "activity": "", "evidence": [ { "id": "F1MLA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLA4" } ] }, { "ec_number": "1.1.1.30", "activity": "", "evidence": [ { "id": "F1MLA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLA4" } ] } ] }, { "uniprot_ac": "Q02337", "gene_name": "BDH1", "activity": [ { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] }, { "ec_number": "1.1.1.30", "activity": "", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] } ] }, { "uniprot_ac": "Q3T046", "gene_name": "BDH2", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q3T046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T046" } ] }, { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "Q3T046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T046" } ] }, { "ec_number": "1.1.1.104", "activity": "cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + NADH + H(+).", "evidence": [ { "id": "Q3T046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T046" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.30", "ec_name": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "1.1.1.30", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30" }, { "id": "1.1.1.30", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.30" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 263, "end_pos": 265 }, { "start_pos": 90, "end_pos": 92 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZHP5-1", "uniprot_ac": "A0AAF6ZHP5", "uniprot_id": "A0AAF6ZHP5_BOVIN", "mass": { "chemical_mass": 70422.0, "monoisotopic_mass": 70422.0 }, "refseq": {}, "gene_names": [ { "name": "C4BPA", "type": "recommended", "evidence": [ { "id": "A0AAF6ZHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5" } ] } ], "protein_names": [ { "name": "Complement component 4 binding protein alpha", "type": "synonym", "evidence": [ { "id": "A0AAF6ZHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C4BPA", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5", "locus": { "chromosome": "16", "start_pos": 4979207, "end_pos": 4938439, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009876", "url": "https://www.ensembl.org/id/ENSBTAG00000009876" } ] } } ], "crossref": [ { "id": "A0AAF6ZHP5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZHP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281651", "url": "https://www.ncbi.nlm.nih.gov/gene/281651", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18453", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18453", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YU71", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YU71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P573", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P573", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P573-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P573-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRRSSFSRKVSMKHQRVPVMILHSKGTMASWPFSRLWSISDPILFQVTLVATLLATVLGSCGIPPYLDFAFPINELNETRFETGTTLRYTCRPGYRISSRKNFLICDGTDNWKYKEFCVKKRCENPGELLNGQVIVKTDYSFGSEIEFSCSEGYVLIGSANSYCQLQDKGVVWSDPLPQCIIAKCEPPPTISNGRHNGGDEDFYTYGSSVTYSCDRDFSMLGKASISCRVENKTIGVWSPSPPSCKKVICVQPVVKDGKITSGFGPIYTYQQSIVYACNKGFRLEGDSLIHCEADNSWNPPPPTCELNGCLGLPHIPHALWERYDHQTQTEQQVYDIGFVLSYKCHFGYKPETDGPTTVTCQSNLEWSPYIECKEVCCPEPNLNNYGSITLHRRPSTSTHCTYISGDKISYECHSKYMFDALCTKHGTWSPRTPECRPDCKSPPVIAHGQHKVVSKFFTFDHQAVYECDKGYILVGAKELSCTSSGWSPAVPQCKALCLKPEIEYGRLSVEKVRYVEPEIITIQCESGYSVVGSENITCSEDRTWYPEVPKCEWEYPEGCEQVVTGRKLLQCLSRPEEVKLALEVYKLSLEIEILQTNKLKKEAFLLREREKNVTCDFNPE", "length": 623, "header": "tr|A0AAF6ZHP5-1|A0AAF6ZHP5_BOVIN Isoform 1 of Complement component 4 binding protein alpha OS=Bos taurus OX=9913 GN=C4BPA PE=4 SV=1 CANONICAL=A0AAF6ZHP5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YU71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU71/entry", "sequence": { "sequence": "MCRKVSMKHQRVPVMILHSKGTMASWPFSRLWSISDPILFQVTLVATLLATVLGSCGIPPYLDFAFPINELNETRFETGTTLRYTCRPGYRISSRKNFLICDGTDNWKYKEFCVKKRCENPGELLNGQVIVKTDYSFGSEIEFSCSEGYVLIGSANSYCQLQDKGVVWSDPLPQCIIAKCEPPPTISNGRHNGGDEDFYTYGSSVTYSCDRDFSMLGKASISCRVENKTIGVWSPSPPSCKKVICVQPVVKDGKITSGFGPIYTYQQSIVYACNKGFRLEGDSLIHCEADNSWNPPPPTCELNGCLGLPHIPHALWERYDHQTQTEQQVYDIGFVLSYKCHFGYKPETDGPTTVTCQSNLEWSPYIECKEVCCPEPNLNNYGSITLHRRPSTSTHCTYISGDKISYECHSKYMFDALCTKHGTWSPRTPECRPDCKSPPVIAHGQHKVVSKFFTFDHQAVYECDKGYILVGAKELSCTSSGWSPAVPQCKALCLKPEIEYGRLSVEKVRYVEPEIITIQCESGYSVVGSENITCSEDRTWYPEVPKCEWEYPEGCEQVVTGRKLLQCLSRPEEVKLALEVYKLSLEIEILQTNKLKKEAFLLREREKNVTCDFNPE", "length": 616, "header": "tr|A0AAF6YU71-1|A0AAF6ZHP5_BOVIN Computationally mapped isoform of Complement component 4 binding protein alpha OS=Bos taurus OX=9913 GN=C4BPA PE=4 SV=1 CANONICAL=A0AAF6ZHP5-1" }, "locus": { "chromosome": "16", "start_pos": 4979010, "end_pos": 4938553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013024.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013024.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013024.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013024.6" } ] } }, { "isoform_ac": "A0AAF6ZHP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5/entry", "sequence": { "sequence": "MGRRRSSFSRKVSMKHQRVPVMILHSKGTMASWPFSRLWSISDPILFQVTLVATLLATVLGSCGIPPYLDFAFPINELNETRFETGTTLRYTCRPGYRISSRKNFLICDGTDNWKYKEFCVKKRCENPGELLNGQVIVKTDYSFGSEIEFSCSEGYVLIGSANSYCQLQDKGVVWSDPLPQCIIAKCEPPPTISNGRHNGGDEDFYTYGSSVTYSCDRDFSMLGKASISCRVENKTIGVWSPSPPSCKKVICVQPVVKDGKITSGFGPIYTYQQSIVYACNKGFRLEGDSLIHCEADNSWNPPPPTCELNGCLGLPHIPHALWERYDHQTQTEQQVYDIGFVLSYKCHFGYKPETDGPTTVTCQSNLEWSPYIECKEVCCPEPNLNNYGSITLHRRPSTSTHCTYISGDKISYECHSKYMFDALCTKHGTWSPRTPECRPDCKSPPVIAHGQHKVVSKFFTFDHQAVYECDKGYILVGAKELSCTSSGWSPAVPQCKALCLKPEIEYGRLSVEKVRYVEPEIITIQCESGYSVVGSENITCSEDRTWYPEVPKCEWEYPEGCEQVVTGRKLLQCLSRPEEVKLALEVYKLSLEIEILQTNKLKKEAFLLREREKNVTCDFNPE", "length": 623, "header": "tr|A0AAF6ZHP5-1|A0AAF6ZHP5_BOVIN Isoform 1 of Complement component 4 binding protein alpha OS=Bos taurus OX=9913 GN=C4BPA PE=4 SV=1 CANONICAL=A0AAF6ZHP5-1" }, "locus": { "chromosome": "16", "start_pos": 4979010, "end_pos": 4940083, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050299.6", "url": "https://www.ensembl.org/id/ENSBTAT00000050299.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047025.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047025.4" } ] } }, { "isoform_ac": "A0ABI0P573-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P573/entry", "sequence": { "sequence": "MCSFSRKVSMKHQRVPVMILHSKGTMASWPFSRLWSISDPILFQVTLVATLLATVLGSCGIPPYLDFAFPINELNETRFETGTTLRYTCRPGYRISSRKNFLICDGTDNWKYKEFCVKKRCENPGELLNGQVIVKTDYSFGSEIEFSCSEGYVLIGSANSYCQLQDKGVVWSDPLPQCIIAKCEPPPTISNGRHNGGDEDFYTYGSSVTYSCDRDFSMLGKASISCRVENKTIGVWSPSPPSCKKVICVQPVVKDGKITSGFGPIYTYQQSIVYACNKGFRLEGDSLIHCEADNSWNPPPPTCELNGCLGLPHIPHALWERYDHQTQTEQQVYDIGFVLSYKCHFGYKPETDGPTTVTCQSNLEWSPYIECKEVCCPEPNLNNYGSITLHRRPSTSTHCTYISGDKISYECHSKYMFDALCTKHGTWSPRTPECRPDCKSPPVIAHGQHKVVSKFFTFDHQAVYECDKGYILVGAKELSCTSSGWSPAVPQCKALCLKPEIEYGRLSVEKVRYVEPEIITIQCESGYSVVGSENITCSEDRTWYPEVPKCEWEYPEGCEQVVTGRKLLQCLSRPEEVKLALEVYKLSLEIEILQTNKLKKEAFLLREREKNVTCDFNPE", "length": 619, "header": "tr|A0ABI0P573-1|A0ABI0P573_BOVIN Computationally mapped isoform of Complement component 4 binding protein alpha OS=Bos taurus OX=9913 GN=C4BPA PE=4 SV=1 CANONICAL=A0AAF6ZHP5-1" }, "locus": { "chromosome": "16", "start_pos": 4979010, "end_pos": 4938553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150274.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150274.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106662.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 538, "end_pos": 540, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHP5" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 122, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 }, { "start_pos": 538, "end_pos": 540 }, { "start_pos": 615, "end_pos": 617 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6YZY8-1", "uniprot_ac": "A0AAF6YZY8", "uniprot_id": "A0AAF6YZY8_BOVIN", "mass": { "chemical_mass": 9942.0, "monoisotopic_mass": 9942.0 }, "refseq": { "ac": "XP_005210616", "name": "anaphase-promoting complex subunit CDC26 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210616" }, "gene_names": [ { "name": "CDC26", "type": "recommended", "evidence": [ { "id": "A0AAF6YZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ] }, { "name": "CDC26", "type": "synonym", "evidence": [ { "id": "XP_005210616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210616" } ] } ], "protein_names": [ { "name": "Anaphase-promoting complex subunit CDC26", "type": "recommended", "evidence": [ { "id": "A0AAF6YZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8/entry#names_and_taxonomy" } ] }, { "name": "Cell division cycle protein 26 homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6YZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8/entry#names_and_taxonomy" } ] }, { "name": "anaphase-promoting complex subunit CDC26 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005210616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210616" } ] } ], "function": [ { "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. May recruit the E2 ubiquitin-conjugating enzymes to the complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8#function" }, { "database": "UniProtKB", "id": "ARBA00046012", "url": "https://www.uniprot.org/uniprotkb/ARBA00046012#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8", "locus": { "chromosome": "8", "start_pos": 102506038, "end_pos": 102517195, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014430", "url": "https://www.ensembl.org/id/ENSBTAG00000014430" } ] } } ], "crossref": [ { "id": "A0AAF6YZY8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6YZY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "777693", "url": "https://www.ncbi.nlm.nih.gov/gene/777693", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28579", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28579", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28579:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28579:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10471", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10471", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005210616", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210616", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMLRRKPTRLELKLDDIEEFESIRKDLETRKKQKEDVDIVGGSDGEGAIGLSSDPKSREQMINDRIGYKPQPKPNNRSSQFGNFEF", "length": 86, "header": "tr|A0AAF6YZY8-1|A0AAF6YZY8_BOVIN Isoform 1 of Anaphase-promoting complex subunit CDC26 OS=Bos taurus OX=9913 GN=CDC26 PE=3 SV=1 CANONICAL=A0AAF6YZY8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YZY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8/entry", "sequence": { "sequence": "MMLRRKPTRLELKLDDIEEFESIRKDLETRKKQKEDVDIVGGSDGEGAIGLSSDPKSREQMINDRIGYKPQPKPNNRSSQFGNFEF", "length": 86, "header": "tr|A0AAF6YZY8-1|A0AAF6YZY8_BOVIN Isoform 1 of Anaphase-promoting complex subunit CDC26 OS=Bos taurus OX=9913 GN=CDC26 PE=3 SV=1 CANONICAL=A0AAF6YZY8-1" }, "locus": { "chromosome": "8", "start_pos": 102510836, "end_pos": 102506279, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019191.4", "url": "https://www.ensembl.org/id/ENSBTAT00000019191.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019191.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019191.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "pmid": "" }, { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "pmid": "" }, { "name": "protein branched polyubiquitination", "id": "GO:0141198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "anaphase-promoting complex", "id": "GO:0005680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZY8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z046-1", "uniprot_ac": "A0AAF6Z046", "uniprot_id": "A0AAF6Z046_BOVIN", "mass": { "chemical_mass": 30678.0, "monoisotopic_mass": 30678.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Neugrin", "type": "recommended", "evidence": [ { "id": "A0AAF6Z046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046/entry#names_and_taxonomy" } ] }, { "name": "Neurite outgrowth-associated protein", "type": "synonym", "evidence": [ { "id": "A0AAF6Z046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046#function" }, { "database": "UniProtKB", "id": "ARBA00003783", "url": "https://www.uniprot.org/uniprotkb/ARBA00003783#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z046", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z046", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13475", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13475", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13475:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13475:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06413", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z046-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSAIGSLPQRPETTEKSHPVPENSKANGGVRCPTQDPDVGSHGADPLHYWGMQDLTSLTRVHTCLHCVFKLPALEARSLHHCTVRYLHREFSESWSVPRLAEGFDVSTDVIRRVLKSKFIPTLEQKLKQDQKVLKKIGLARSIPELPGPGDSSKPLSAGQSVSGSLLIPGDEASSRGHGHSTALKAIELNTQSTNITTRQTERNKGVQGLEEGKDFVPVAAGHPTSTCRGARGIDSDGLPSDKRLEELKAGEAGDQIFSKRVVQRGREFFDSNGNFLYRI", "length": 281, "header": "tr|A0AAF6Z046-1|A0AAF6Z046_BOVIN Isoform 1 of Neugrin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6Z046-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z046-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046/entry", "sequence": { "sequence": "MVSAIGSLPQRPETTEKSHPVPENSKANGGVRCPTQDPDVGSHGADPLHYWGMQDLTSLTRVHTCLHCVFKLPALEARSLHHCTVRYLHREFSESWSVPRLAEGFDVSTDVIRRVLKSKFIPTLEQKLKQDQKVLKKIGLARSIPELPGPGDSSKPLSAGQSVSGSLLIPGDEASSRGHGHSTALKAIELNTQSTNITTRQTERNKGVQGLEEGKDFVPVAAGHPTSTCRGARGIDSDGLPSDKRLEELKAGEAGDQIFSKRVVQRGREFFDSNGNFLYRI", "length": 281, "header": "tr|A0AAF6Z046-1|A0AAF6Z046_BOVIN Isoform 1 of Neugrin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6Z046-1" }, "locus": { "chromosome": "21", "start_pos": 21641202, "end_pos": 21636155, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019282.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019282.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019282.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019282.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z046", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z046" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z059-1", "uniprot_ac": "A0AAF6Z059", "uniprot_id": "A0AAF6Z059_BOVIN", "mass": { "chemical_mass": 21733.0, "monoisotopic_mass": 21733.0 }, "refseq": {}, "gene_names": [ { "name": "RHOC", "type": "recommended", "evidence": [ { "id": "A0AAF6Z059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ] } ], "protein_names": [ { "name": "Ras homolog family member C", "type": "synonym", "evidence": [ { "id": "A0AAF6Z059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHOC", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059", "locus": { "chromosome": "3", "start_pos": 30625071, "end_pos": 30618175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014299", "url": "https://www.ensembl.org/id/ENSBTAG00000014299" } ] } } ], "crossref": [ { "id": "A0AAF6Z059", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z059", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01870", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01870", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24072", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24072", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z059-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQAPVLAVSLESHLS", "length": 193, "header": "tr|A0AAF6Z059-1|A0AAF6Z059_BOVIN Isoform 1 of Ras homolog family member C OS=Bos taurus OX=9913 GN=RHOC PE=3 SV=1 CANONICAL=A0AAF6Z059-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z059-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059/entry", "sequence": { "sequence": "MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQAPVLAVSLESHLS", "length": 193, "header": "tr|A0AAF6Z059-1|A0AAF6Z059_BOVIN Isoform 1 of Ras homolog family member C OS=Bos taurus OX=9913 GN=RHOC PE=3 SV=1 CANONICAL=A0AAF6Z059-1" }, "locus": { "chromosome": "3", "start_pos": 30624524, "end_pos": 30621558, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018998.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018998.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018998.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018998.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "apical junction assembly", "id": "GO:0043297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043297", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "positive regulation of protein-containing complex assembly", "id": "GO:0031334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031334", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z059", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z059" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0D5-1", "uniprot_ac": "A0AAF6Z0D5", "uniprot_id": "A0AAF6Z0D5_BOVIN", "mass": { "chemical_mass": 16555.0, "monoisotopic_mass": 16555.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM88", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ] } ], "protein_names": [ { "name": "Transmembrane protein 88", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM88", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5", "locus": { "chromosome": "19", "start_pos": 27546951, "end_pos": 27545778, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014693", "url": "https://www.ensembl.org/id/ENSBTAG00000014693" } ] } } ], "crossref": [ { "id": "A0AAF6Z0D5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR033355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28628", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28628", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28628:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28628:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27917", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27917", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADVPGAQRPVPGGGPEPRDPLDCWACAVLVTAQNLLVAAFNLLLLALVLGTILLPAVTMLGFGFLCHSQAPPCTAHLRDPGFTALLVTGFLLLVPLLVLALASYRRLCLRLRLADCLVPYSRALYRRRRNPQPRPARSSPGPQVAPTSGKVWV", "length": 154, "header": "tr|A0AAF6Z0D5-1|A0AAF6Z0D5_BOVIN Isoform 1 of Transmembrane protein 88 OS=Bos taurus OX=9913 GN=TMEM88 PE=3 SV=1 CANONICAL=A0AAF6Z0D5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5/entry", "sequence": { "sequence": "MADVPGAQRPVPGGGPEPRDPLDCWACAVLVTAQNLLVAAFNLLLLALVLGTILLPAVTMLGFGFLCHSQAPPCTAHLRDPGFTALLVTGFLLLVPLLVLALASYRRLCLRLRLADCLVPYSRALYRRRRNPQPRPARSSPGPQVAPTSGKVWV", "length": 154, "header": "tr|A0AAF6Z0D5-1|A0AAF6Z0D5_BOVIN Isoform 1 of Transmembrane protein 88 OS=Bos taurus OX=9913 GN=TMEM88 PE=3 SV=1 CANONICAL=A0AAF6Z0D5-1" }, "locus": { "chromosome": "19", "start_pos": 27546561, "end_pos": 27545977, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019555.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019555.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019555.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019555.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 148, "start_aa": "Thr", "end_pos": 148, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr148", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0D5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 148 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0J8-1", "uniprot_ac": "A0AAF6Z0J8", "uniprot_id": "A0AAF6Z0J8_BOVIN", "mass": { "chemical_mass": 37716.0, "monoisotopic_mass": 37716.0 }, "refseq": {}, "gene_names": [ { "name": "ATP6V0D1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ] } ], "protein_names": [ { "name": "V-type proton ATPase subunit", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8#function" }, { "database": "UniProtKB", "id": "PIRNR018497", "url": "https://www.uniprot.org/uniprotkb/PIRNR018497#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATP6V0D1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8", "locus": { "chromosome": "18", "start_pos": 35045981, "end_pos": 35085645, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014553", "url": "https://www.ensembl.org/id/ENSBTAG00000014553" } ] } } ], "crossref": [ { "id": "A0AAF6Z0J8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0J8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0J8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHELKEQECRNIVWIAECIAQRHRAKIDNYIPIF", "length": 329, "header": "tr|A0AAF6Z0J8-1|A0AAF6Z0J8_BOVIN Isoform 1 of V-type proton ATPase subunit OS=Bos taurus OX=9913 GN=ATP6V0D1 PE=3 SV=1 CANONICAL=A0AAF6Z0J8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0J8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8/entry", "sequence": { "sequence": "MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHELKEQECRNIVWIAECIAQRHRAKIDNYIPIF", "length": 329, "header": "tr|A0AAF6Z0J8-1|A0AAF6Z0J8_BOVIN Isoform 1 of V-type proton ATPase subunit OS=Bos taurus OX=9913 GN=ATP6V0D1 PE=3 SV=1 CANONICAL=A0AAF6Z0J8-1" }, "locus": { "chromosome": "18", "start_pos": 35085567, "end_pos": 35046985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019346.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019346.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019346.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019346.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" }, { "name": "vacuolar proton-transporting V-type ATPase complex", "id": "GO:0016471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" }, { "name": "proton-transporting V-type ATPase, V0 domain", "id": "GO:0033179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033179", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular iron ion homeostasis", "id": "GO:0006879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" }, { "name": "cellular response to increased oxygen levels", "id": "GO:0036295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036295", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" }, { "name": "synaptic vesicle lumen acidification", "id": "GO:0097401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097401", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "proton-transporting ATPase activity, rotational mechanism", "id": "GO:0046961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046961", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0J8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0J8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0T9-1", "uniprot_ac": "A0AAF6Z0T9", "uniprot_id": "A0AAF6Z0T9_BOVIN", "mass": { "chemical_mass": 30755.0, "monoisotopic_mass": 30755.0 }, "refseq": {}, "gene_names": [ { "name": "TBCB", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" } ] } ], "protein_names": [ { "name": "Tubulin folding cofactor B", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBCB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9", "locus": { "chromosome": "18", "start_pos": 46783614, "end_pos": 46775445, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015004", "url": "https://www.ensembl.org/id/ENSBTAG00000015004" } ] } } ], "crossref": [ { "id": "A0AAF6Z0T9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01789", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01789", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR18916", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18916", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18916:SF85", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18916:SF85", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01302", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01302", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z0T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGLPQRRKGARNEPRLQRLGTRPQRGGARWNLRFQRMGAGPGKIRGCRELRAGPNGVGLGIPSGSQRCKLQLVVGSPASCMELELYGPDDKFCCKLDQDDALLGSYPVDDGCRIHVIDHSGARLGEYEDISKVEKYEISQEAYEQRQDSIRSFLKRNKLGRFNEEERAQQEAENSQRLIEEEAQASTIPVGSRCEVRTPGQPPRRGTVMYVGLTDFKPGYWIGIRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPSVVTVGDFPEEDYGLDEM", "length": 274, "header": "tr|A0AAF6Z0T9-1|A0AAF6Z0T9_BOVIN Isoform 1 of Tubulin folding cofactor B OS=Bos taurus OX=9913 GN=TBCB PE=3 SV=1 CANONICAL=A0AAF6Z0T9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9/entry", "sequence": { "sequence": "MEGLPQRRKGARNEPRLQRLGTRPQRGGARWNLRFQRMGAGPGKIRGCRELRAGPNGVGLGIPSGSQRCKLQLVVGSPASCMELELYGPDDKFCCKLDQDDALLGSYPVDDGCRIHVIDHSGARLGEYEDISKVEKYEISQEAYEQRQDSIRSFLKRNKLGRFNEEERAQQEAENSQRLIEEEAQASTIPVGSRCEVRTPGQPPRRGTVMYVGLTDFKPGYWIGIRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPSVVTVGDFPEEDYGLDEM", "length": 274, "header": "tr|A0AAF6Z0T9-1|A0AAF6Z0T9_BOVIN Isoform 1 of Tubulin folding cofactor B OS=Bos taurus OX=9913 GN=TBCB PE=3 SV=1 CANONICAL=A0AAF6Z0T9-1" }, "locus": { "chromosome": "18", "start_pos": 46783453, "end_pos": 46775453, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019973.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019973.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019973.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019973.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "alpha-tubulin binding", "id": "GO:0043014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043014", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tubulin complex assembly", "id": "GO:0007021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007021", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" } ], "pmid": "" }, { "name": "post-chaperonin tubulin folding pathway", "id": "GO:0007023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007023", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0T9" }, { "id": "PS50245", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50245" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CAP-Gly", "eco_id": "ECO_0000259", "start_pos": 213, "end_pos": 255, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0U5-1", "uniprot_ac": "A0AAF6Z0U5", "uniprot_id": "A0AAF6Z0U5_BOVIN", "mass": { "chemical_mass": 46489.0, "monoisotopic_mass": 46489.0 }, "refseq": { "ac": "XP_005201519", "name": "eukaryotic initiation factor 4A-II isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201519" }, "gene_names": [ { "name": "EIF4A2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "name": "EIF4A2", "type": "synonym", "evidence": [ { "id": "XP_005201519", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201519" } ] } ], "protein_names": [ { "name": "RNA helicase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic initiation factor 4A-II isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201519", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201519" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF4A2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5", "locus": { "chromosome": "1", "start_pos": 80467443, "end_pos": 80474083, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014724", "url": "https://www.ensembl.org/id/ENSBTAG00000014724" } ] } } ], "crossref": [ { "id": "A0AAF6Z0U5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0U5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18046", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18046", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "286819", "url": "https://www.ncbi.nlm.nih.gov/gene/286819", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005201519", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201519", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 408, "header": "tr|A0AAF6Z0U5-1|A0AAF6Z0U5_BOVIN Isoform 1 of RNA helicase OS=Bos taurus OX=9913 GN=EIF4A2 PE=3 SV=1 CANONICAL=A0AAF6Z0U5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5/entry", "sequence": { "sequence": "MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 408, "header": "tr|A0AAF6Z0U5-1|A0AAF6Z0U5_BOVIN Isoform 1 of RNA helicase OS=Bos taurus OX=9913 GN=EIF4A2 PE=3 SV=1 CANONICAL=A0AAF6Z0U5-1" }, "locus": { "chromosome": "1", "start_pos": 80473721, "end_pos": 80468079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019596.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019596.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019596.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019596.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0U5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" }, { "id": "PS51195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEAD-box RNA helicase Q", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 62, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 236, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 247, "end_pos": 408, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" }, { "id": "PRU00552", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00552" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Q motif", "eco_id": "ECO_0000256", "start_pos": 34, "end_pos": 62, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.4.13", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13" }, { "id": "3.6.4.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.13" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 394, "end_pos": 396 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0W3-1", "uniprot_ac": "A0AAF6Z0W3", "uniprot_id": "A0AAF6Z0W3_BOVIN", "mass": { "chemical_mass": 52977.0, "monoisotopic_mass": 52977.0 }, "refseq": {}, "gene_names": [ { "name": "LANCL1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] } ], "protein_names": [ { "name": "Glutathione S-transferase LANCL1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.18", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3/entry#names_and_taxonomy" } ] }, { "name": "40 kDa erythrocyte membrane protein", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3/entry#names_and_taxonomy" } ] }, { "name": "LanC-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3#function" }, { "database": "UniProtKB", "id": "ARBA00057480", "url": "https://www.uniprot.org/uniprotkb/ARBA00057480#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LANCL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3", "locus": { "chromosome": "2", "start_pos": 98188212, "end_pos": 98237800, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015066", "url": "https://www.ensembl.org/id/ENSBTAG00000015066" } ] } } ], "crossref": [ { "id": "A0AAF6Z0W3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0W3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04794", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04794", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12736:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12736:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16437", "url": "https://www.rhea-db.org/rhea/16437", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "51220", "url": "https://www.rhea-db.org/rhea/51220", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRQGRASGLAKALIGPAGRKWAVKALLQFLSGGGGVSGQRPYRALGPCTSSCLKSQECERGVQNGAPSSRLVSGIMAQRAFPNPYADYNKSLAEGYFDSAGRLTPEFSQRLNNKIRELLQQMERGLKSADPRDSTVYTGWAGIAVLYLHLYDVFGDPNYLQMAHGYVKQSLNSLSKHSITFLCGDGGPLAVAAVVHHKMNNEKQAEECITRLIHLNKIDPHAPSEMLYGRMGYISALLFVNKNFGEEKIPQSHIQQICETVLTSGEDLARKRRFTGKTPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSHAKLHNLVKPSVDYVCQLKFPSGNYPPCVDDSRDLLIHWCHGAPGVIYMLTQAYKVFKEERYLNDAYQCADVIWQYGLLKKGYGLCHGTAGNAYAFLSLYSLTQDAKYLYRACKFAEWCLDYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL", "length": 474, "header": "tr|A0AAF6Z0W3-1|A0AAF6Z0W3_BOVIN Isoform 1 of Glutathione S-transferase LANCL1 OS=Bos taurus OX=9913 GN=LANCL1 PE=3 SV=1 CANONICAL=A0AAF6Z0W3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3/entry", "sequence": { "sequence": "MRQGRASGLAKALIGPAGRKWAVKALLQFLSGGGGVSGQRPYRALGPCTSSCLKSQECERGVQNGAPSSRLVSGIMAQRAFPNPYADYNKSLAEGYFDSAGRLTPEFSQRLNNKIRELLQQMERGLKSADPRDSTVYTGWAGIAVLYLHLYDVFGDPNYLQMAHGYVKQSLNSLSKHSITFLCGDGGPLAVAAVVHHKMNNEKQAEECITRLIHLNKIDPHAPSEMLYGRMGYISALLFVNKNFGEEKIPQSHIQQICETVLTSGEDLARKRRFTGKTPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSHAKLHNLVKPSVDYVCQLKFPSGNYPPCVDDSRDLLIHWCHGAPGVIYMLTQAYKVFKEERYLNDAYQCADVIWQYGLLKKGYGLCHGTAGNAYAFLSLYSLTQDAKYLYRACKFAEWCLDYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL", "length": 474, "header": "tr|A0AAF6Z0W3-1|A0AAF6Z0W3_BOVIN Isoform 1 of Glutathione S-transferase LANCL1 OS=Bos taurus OX=9913 GN=LANCL1 PE=3 SV=1 CANONICAL=A0AAF6Z0W3-1" }, "locus": { "chromosome": "2", "start_pos": 98237691, "end_pos": 98191188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020055.4", "url": "https://www.ensembl.org/id/ENSBTAT00000020055.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020055.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020055.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "glutathione transferase activity", "id": "GO:0004364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "glutathione binding", "id": "GO:0043295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043295", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor binding", "id": "GO:0050750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050750", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "peptide modification", "id": "GO:0031179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031179", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" }, { "name": "cellular detoxification", "id": "GO:1990748", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990748", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16437", "name": "", "equation": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "F1MUX5-1", "F1MX44-1", "A0ABI0P5M0-1", "A0AAA9TW47-1", "F6QEM8-1", "A0ABI0P3R2-1", "A0AAF6Z0W3-1", "P28801-1", "Q2KJG4-1", "A0A3Q1LMV5-1", "F1MVX2-1", "Q28035-1", "Q9N0V4-1", "Q2NL00-1", "F1MXY2-1", "E1BED9-1", "A0ABI0P006-1", "Q5E9G0-1", "Q64L89-1", "A0A452DIU1-1", "F1MGZ9-1", "A0AAA9TXU3-1", "E1BJX2-1" ], "evidence": [ { "id": "16437", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16437" } ] }, { "id": "51220", "name": "", "equation": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z0W3-1", "Q2KJG4-1", "F1MVX2-1", "Q95L14-1" ], "evidence": [ { "id": "51220", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51220" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A452DIU1", "gene_name": "LOC327709", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TXU3", "gene_name": "GSTZ1", "activity": [ { "ec_number": "5.2.1.2", "activity": "4-maleylacetoacetate = 4-fumarylacetoacetate.", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "5.2.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] } ] }, { "uniprot_ac": "A0AAF6Z0W3", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] } ] }, { "uniprot_ac": "A0ABI0P006", "gene_name": "LOC785216", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] } ] }, { "uniprot_ac": "A0ABI0P3R2", "gene_name": "GSTT2", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2.", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] } ] }, { "uniprot_ac": "A0ABI0P5M0", "gene_name": "GSTA1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] } ] }, { "uniprot_ac": "E1BED9", "gene_name": "GSTO2", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] } ] }, { "uniprot_ac": "E1BJX2", "gene_name": "GSTT4", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] } ] }, { "uniprot_ac": "F1MGZ9", "gene_name": "HPGDS", "activity": [ { "ec_number": "5.3.99.2", "activity": "prostaglandin H2 = prostaglandin D2.", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "5.3.99.2", "activity": "", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] } ] }, { "uniprot_ac": "F1MUX5", "gene_name": "LOC100295687", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MUX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUX5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MUX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUX5" } ] } ] }, { "uniprot_ac": "F1MVX2", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MVX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVX2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MVX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVX2" } ] } ] }, { "uniprot_ac": "F1MX44", "gene_name": "GSTA5", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX44" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX44" } ] } ] }, { "uniprot_ac": "F1MXY2", "gene_name": "MGST1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXY2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXY2" } ] } ] }, { "uniprot_ac": "F6QEM8", "gene_name": "LOC783879", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F6QEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QEM8" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F6QEM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QEM8" } ] } ] }, { "uniprot_ac": "O18879", "gene_name": "GSTA2", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "O18879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18879" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "O18879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18879" } ] } ] }, { "uniprot_ac": "P28801", "gene_name": "GSTP1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "P28801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P28801" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "P28801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P28801" } ] } ] }, { "uniprot_ac": "Q28035", "gene_name": "GSTA1", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "5.3.3.-", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] } ] }, { "uniprot_ac": "Q2KJG4", "gene_name": "MGST2", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = leukotriene A4 + glutathione.", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "4.4.1.20", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] } ] }, { "uniprot_ac": "Q2NL00", "gene_name": "GSTT1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ] } ] }, { "uniprot_ac": "Q5E9G0", "gene_name": "GSTA4", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q5E9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q5E9G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ] } ] }, { "uniprot_ac": "Q64L89", "gene_name": "MGST1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q64L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q64L89" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q64L89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q64L89" } ] } ] }, { "uniprot_ac": "Q95L14", "gene_name": "PTGES", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "5.3.99.3", "activity": "prostaglandin H2 = prostaglandin E2.", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "5.3.99.3", "activity": "", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] } ] }, { "uniprot_ac": "Q9N0V4", "gene_name": "GSTM1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q9N0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0V4" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q9N0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0V4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" }, { "id": "PIRSR607822-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR607822-1" } ], "binding_site_uniprot": 351, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 351, "end_pos": 351, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" }, { "id": "PIRSR607822-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR607822-1" } ], "binding_site_uniprot": 397, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 397, "end_pos": 397, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" }, { "id": "PIRSR607822-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR607822-1" } ], "binding_site_uniprot": 398, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 398, "end_pos": 398, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.18", "ec_name": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "2.5.1.18", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18" }, { "id": "2.5.1.18", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.18" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0W4-1", "uniprot_ac": "A0AAF6Z0W4", "uniprot_id": "A0AAF6Z0W4_BOVIN", "mass": { "chemical_mass": 7889.0, "monoisotopic_mass": 7889.0 }, "refseq": {}, "gene_names": [ { "name": "LAMTOR4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ] } ], "protein_names": [ { "name": "Ragulator complex protein LAMTOR4", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4/entry#names_and_taxonomy" } ] }, { "name": "Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4", "type": "synonym", "evidence": [ { "id": "A0AAF6Z0W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4#function" }, { "database": "UniProtKB", "id": "ARBA00045571", "url": "https://www.uniprot.org/uniprotkb/ARBA00045571#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAMTOR4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4", "locus": { "chromosome": "25", "start_pos": 36252207, "end_pos": 36255447, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015009", "url": "https://www.ensembl.org/id/ENSBTAG00000015009" } ] } } ], "crossref": [ { "id": "A0AAF6Z0W4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0W4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR034601", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034601", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33967", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33967", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33967:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33967:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSGDLENDEQAASAISELVSTACGFRLHQGMSVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV", "length": 72, "header": "tr|A0AAF6Z0W4-1|A0AAF6Z0W4_BOVIN Isoform 1 of Ragulator complex protein LAMTOR4 OS=Bos taurus OX=9913 GN=LAMTOR4 PE=3 SV=1 CANONICAL=A0AAF6Z0W4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4/entry", "sequence": { "sequence": "MSSGDLENDEQAASAISELVSTACGFRLHQGMSVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV", "length": 72, "header": "tr|A0AAF6Z0W4-1|A0AAF6Z0W4_BOVIN Isoform 1 of Ragulator complex protein LAMTOR4 OS=Bos taurus OX=9913 GN=LAMTOR4 PE=3 SV=1 CANONICAL=A0AAF6Z0W4-1" }, "locus": { "chromosome": "25", "start_pos": 36255447, "end_pos": 36252441, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019980.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019980.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019980.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019980.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" }, { "name": "protein localization to lysosome", "id": "GO:0061462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061462", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" }, { "name": "regulation of cell size", "id": "GO:0008361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008361", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" }, { "name": "Ragulator complex", "id": "GO:0071986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071986", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" }, { "name": "FNIP-folliculin RagC/D GAP", "id": "GO:1990877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990877", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z0W9-1", "uniprot_ac": "A0AAF6Z0W9", "uniprot_id": "A0AAF6Z0W9_BOVIN", "mass": { "chemical_mass": 51018.0, "monoisotopic_mass": 51018.0 }, "refseq": {}, "gene_names": [ { "name": "FBXO9", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ] } ], "protein_names": [ { "name": "F-box only protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z0W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9#function" }, { "database": "UniProtKB", "id": "RU369085", "url": "https://www.uniprot.org/uniprotkb/RU369085#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9", "locus": { "chromosome": "23", "start_pos": 25297258, "end_pos": 25275775, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015083", "url": "https://www.ensembl.org/id/ENSBTAG00000015083" } ] } } ], "crossref": [ { "id": "A0AAF6Z0W9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z0W9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22089", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22089", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12874", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12874", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12874:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12874:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z0W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAEEDCHSEAVREGDDDDENESPAETDLQAQLQRFRAQWMFELAPGGGSGNLESRPCRAARGSLLRAADTRGKQELAKEEKLSARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDTDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQTHISALPMEVLMYVFRWVVSSDLDLRSLEQLSQVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYVRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKALDHKYRYFRRAPVQEADQNFHVGLQLCSSGHQSFNKLIWIHHSCHITYKSTGETAVTAFEIDKMYTPLLFARVRSYTAFSERPL", "length": 439, "header": "tr|A0AAF6Z0W9-1|A0AAF6Z0W9_BOVIN Isoform 1 of F-box only protein OS=Bos taurus OX=9913 GN=FBXO9 PE=4 SV=1 CANONICAL=A0AAF6Z0W9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z0W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9/entry", "sequence": { "sequence": "MAEAEEDCHSEAVREGDDDDENESPAETDLQAQLQRFRAQWMFELAPGGGSGNLESRPCRAARGSLLRAADTRGKQELAKEEKLSARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDTDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQTHISALPMEVLMYVFRWVVSSDLDLRSLEQLSQVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYVRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKALDHKYRYFRRAPVQEADQNFHVGLQLCSSGHQSFNKLIWIHHSCHITYKSTGETAVTAFEIDKMYTPLLFARVRSYTAFSERPL", "length": 439, "header": "tr|A0AAF6Z0W9-1|A0AAF6Z0W9_BOVIN Isoform 1 of F-box only protein OS=Bos taurus OX=9913 GN=FBXO9 PE=4 SV=1 CANONICAL=A0AAF6Z0W9-1" }, "locus": { "chromosome": "23", "start_pos": 25296757, "end_pos": 25276162, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020074.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020074.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020074.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020074.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "pmid": "" }, { "name": "regulation of TOR signaling", "id": "GO:0032006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z0W9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z0W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W9" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 177, "end_pos": 228, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 339, "end_pos": 341 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z132-1", "uniprot_ac": "A0AAF6Z132", "uniprot_id": "A0AAF6Z132_BOVIN", "mass": { "chemical_mass": 9486.0, "monoisotopic_mass": 9486.0 }, "refseq": {}, "gene_names": [ { "name": "SMPX", "type": "recommended", "evidence": [ { "id": "A0AAF6Z132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132" } ] } ], "protein_names": [ { "name": "Small muscular protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132#function" }, { "database": "UniProtKB", "id": "ARBA00002671", "url": "https://www.uniprot.org/uniprotkb/ARBA00002671#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMPX", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132", "locus": { "chromosome": "X", "start_pos": 121581650, "end_pos": 121528445, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015204", "url": "https://www.ensembl.org/id/ENSBTAG00000015204" } ] } } ], "crossref": [ { "id": "A0AAF6Z132", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z132", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR17416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17416:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17416:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z132-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VSMSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEIEEGAPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ", "length": 88, "header": "tr|A0AAF6Z132-1|A0AAF6Z132_BOVIN Isoform 1 of Small muscular protein OS=Bos taurus OX=9913 GN=SMPX PE=3 SV=1 CANONICAL=A0AAF6Z132-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z132-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132/entry", "sequence": { "sequence": "VSMSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEIEEGAPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ", "length": 88, "header": "tr|A0AAF6Z132-1|A0AAF6Z132_BOVIN Isoform 1 of Small muscular protein OS=Bos taurus OX=9913 GN=SMPX PE=3 SV=1 CANONICAL=A0AAF6Z132-1" }, "locus": { "chromosome": "X", "start_pos": 121550273, "end_pos": 121532120, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020229.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020229.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020229.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020229.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132" } ], "pmid": "" }, { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132" } ], "pmid": "" }, { "name": "costamere", "id": "GO:0043034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043034", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132" } ], "pmid": "" }, { "name": "muscle tendon junction", "id": "GO:0005927", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005927", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z132", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z132" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z153-1", "uniprot_ac": "A0AAF6Z153", "uniprot_id": "A0AAF6Z153_BOVIN", "mass": { "chemical_mass": 23342.0, "monoisotopic_mass": 23342.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ribosomal protein L10e/L16 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z153", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z153", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z153", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01433", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01433", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11726", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11726", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z153", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z153-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPSAGPSSSSLAARRSTSLRSGDLPSSTRMNLRTWWQKSDSSQTAVGSNTSLIVVLWTNGGPCTHEHQCCPLLNHAHQ", "length": 210, "header": "tr|A0AAF6Z153-1|A0AAF6Z153_BOVIN Isoform 1 of Ribosomal protein L10e/L16 domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6Z153-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z153-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153/entry", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQPSAGPSSSSLAARRSTSLRSGDLPSSTRMNLRTWWQKSDSSQTAVGSNTSLIVVLWTNGGPCTHEHQCCPLLNHAHQ", "length": 210, "header": "tr|A0AAF6Z153-1|A0AAF6Z153_BOVIN Isoform 1 of Ribosomal protein L10e/L16 domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6Z153-1" }, "locus": { "chromosome": "1", "start_pos": 54227649, "end_pos": 54226968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020266.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020266.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020266.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020266.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z153", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z153", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "large ribosomal subunit", "id": "GO:0015934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015934", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z153", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z153" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 181, "end_pos": 183 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z178-1", "uniprot_ac": "A0AAF6Z178", "uniprot_id": "A0AAF6Z178_BOVIN", "mass": { "chemical_mass": 25479.0, "monoisotopic_mass": 25479.0 }, "refseq": {}, "gene_names": [ { "name": "RPS8", "type": "recommended", "evidence": [ { "id": "A0AAF6Z178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ] } ], "protein_names": [ { "name": "40S ribosomal protein S8", "type": "recommended", "evidence": [ { "id": "A0AAF6Z178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178", "locus": { "chromosome": "3", "start_pos": 101230979, "end_pos": 101235113, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015285", "url": "https://www.ensembl.org/id/ENSBTAG00000015285" } ] } } ], "crossref": [ { "id": "A0AAF6Z178", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z178", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z178-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKASHLKAGTRSYGTQ", "length": 220, "header": "tr|A0AAF6Z178-1|A0AAF6Z178_BOVIN Isoform 1 of 40S ribosomal protein S8 OS=Bos taurus OX=9913 GN=RPS8 PE=3 SV=1 CANONICAL=A0AAF6Z178-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z178-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178/entry", "sequence": { "sequence": "MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKASHLKAGTRSYGTQ", "length": 220, "header": "tr|A0AAF6Z178-1|A0AAF6Z178_BOVIN Isoform 1 of 40S ribosomal protein S8 OS=Bos taurus OX=9913 GN=RPS8 PE=3 SV=1 CANONICAL=A0AAF6Z178-1" }, "locus": { "chromosome": "3", "start_pos": 101235090, "end_pos": 101231440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020326.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020326.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020326.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020326.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z178", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z178" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 64, "end_pos": 66 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZH94-1", "uniprot_ac": "A0AAF6ZH94", "uniprot_id": "A0AAF6ZH94_BOVIN", "mass": { "chemical_mass": 41719.0, "monoisotopic_mass": 41719.0 }, "refseq": {}, "gene_names": [ { "name": "ZDHHC9", "type": "recommended", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] } ], "protein_names": [ { "name": "Palmitoyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.225", "type": "synonym", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZDHHC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94", "locus": { "chromosome": "X", "start_pos": 13835662, "end_pos": 13864864, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015354", "url": "https://www.ensembl.org/id/ENSBTAG00000015354" } ] } } ], "crossref": [ { "id": "A0AAF6ZH94", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZH94", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22883", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22883", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22883:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22883:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01529", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01529", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "36683", "url": "https://www.rhea-db.org/rhea/36683", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z1E8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZH94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTYPPLAHLTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQEASTSLLPQGPAPIDHLSNEMPEDTSTPEEMPPPEPPEPPQEVTEAEK", "length": 371, "header": "tr|A0AAF6ZH94-1|A0AAF6ZH94_BOVIN Isoform 1 of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC9 PE=3 SV=1 CANONICAL=A0AAF6ZH94-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z1E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1E8/entry", "sequence": { "sequence": "MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTYPPLAIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQEASTSLLPQGPAPIDHLSNEMPEDTSTPEEMPPPEPPEPPQEVTEAEK", "length": 334, "header": "tr|A0AAF6Z1E8-1|A0AAF6ZH94_BOVIN Computationally mapped isoform of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC9 PE=3 SV=1 CANONICAL=A0AAF6ZH94-1" }, "locus": { "chromosome": "X", "start_pos": 13862972, "end_pos": 13836426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020418.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020418.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020418.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020418.5" } ] } }, { "isoform_ac": "A0AAF6ZH94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94/entry", "sequence": { "sequence": "MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTYPPLAHLTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQEASTSLLPQGPAPIDHLSNEMPEDTSTPEEMPPPEPPEPPQEVTEAEK", "length": 371, "header": "tr|A0AAF6ZH94-1|A0AAF6ZH94_BOVIN Isoform 1 of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC9 PE=3 SV=1 CANONICAL=A0AAF6ZH94-1" }, "locus": { "chromosome": "X", "start_pos": 13862972, "end_pos": 13836426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048680.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048680.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045675.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045675.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" }, { "name": "palmitoyltransferase complex", "id": "GO:0002178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002178", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-cysteine S-palmitoyltransferase activity", "id": "GO:0019706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" }, { "name": "Ras palmitoyltransferase activity", "id": "GO:0043849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043849", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" }, { "name": "host-mediated activation of viral process", "id": "GO:0044794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" }, { "name": "positive regulation of pyroptotic inflammatory response", "id": "GO:0140639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140639", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" }, { "name": "positive regulation of cGAS/STING signaling pathway", "id": "GO:0141111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141111", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH94", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36683", "name": "", "equation": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X756-1", "E1BPA5-1", "F1MVC6-1", "E1B987-1", "E1BJK1-1", "F6R785-1", "A0AAA9TDW4-1", "A0AAA9TVJ9-1", "A0AAA9TM40-1", "E1B6X9-1", "E1BKA0-1", "E1BK60-1", "Q58CU4-1", "A2VDT6-1", "A0AAF6ZH94-1", "A0AAA9RZ07-1", "Q0VC89-1", "E1BLT8-1", "G3MXF3-1", "P15103-1", "Q2HJ95-1", "Q58DA8-1", "A0A3Q1M794-1", "A0A3Q1LVW6-1", "Q58DT3-1", "A0A3Q1M403-1", "A0ABI0NXA5-1" ], "evidence": [ { "id": "36683", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36683" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVW6", "gene_name": "ZDHHC13", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] } ] }, { "uniprot_ac": "A0A3Q1M403", "gene_name": "", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] } ] }, { "uniprot_ac": "A0A3Q1M794", "gene_name": "ZDHHC3", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] } ] }, { "uniprot_ac": "A0AAA9RZ07", "gene_name": "ZDHHC8", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] } ] }, { "uniprot_ac": "A0AAA9TDW4", "gene_name": "ZDHHC7", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] } ] }, { "uniprot_ac": "A0AAA9TM40", "gene_name": "ZDHHC18", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] } ] }, { "uniprot_ac": "A0AAA9TVJ9", "gene_name": "ZDHHC23", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] } ] }, { "uniprot_ac": "A0AAF6ZH94", "gene_name": "ZDHHC9", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] } ] }, { "uniprot_ac": "A0ABI0NXA5", "gene_name": "ZDHHC15", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] } ] }, { "uniprot_ac": "A2VDT6", "gene_name": "ZDHHC21", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] } ] }, { "uniprot_ac": "E1B6X9", "gene_name": "ZDHHC12", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] } ] }, { "uniprot_ac": "E1B987", "gene_name": "ZDHHC22", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] } ] }, { "uniprot_ac": "E1BJK1", "gene_name": "ZDHHC17", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] } ] }, { "uniprot_ac": "E1BK60", "gene_name": "ZDHHC14", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BK60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK60" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BK60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK60" } ] } ] }, { "uniprot_ac": "E1BKA0", "gene_name": "ZDHHC4", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA0" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA0" } ] } ] }, { "uniprot_ac": "E1BLT8", "gene_name": "ZDHHC5", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLT8" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLT8" } ] } ] }, { "uniprot_ac": "E1BPA5", "gene_name": "ZDHHC24", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ] } ] }, { "uniprot_ac": "F1MVC6", "gene_name": "", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "F1MVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "F1MVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC6" } ] } ] }, { "uniprot_ac": "F6R785", "gene_name": "ZDHHC1", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "F6R785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R785" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "F6R785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R785" } ] } ] }, { "uniprot_ac": "G3MXF3", "gene_name": "ZDHHC2", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "G3MXF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXF3" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "G3MXF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXF3" } ] } ] }, { "uniprot_ac": "G3X756", "gene_name": "", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "G3X756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X756" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "G3X756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X756" } ] } ] }, { "uniprot_ac": "P15103", "gene_name": "GLUL", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "P15103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15103" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "P15103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15103" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "P15103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15103" } ] } ] }, { "uniprot_ac": "Q0VC89", "gene_name": "ZDHHC20", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q0VC89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC89" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q0VC89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC89" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q0VC89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC89" } ] } ] }, { "uniprot_ac": "Q2HJ95", "gene_name": "ZDHHC6", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q2HJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ95" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q2HJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ95" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q2HJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ95" } ] } ] }, { "uniprot_ac": "Q58CU4", "gene_name": "ZDHHC16", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q58CU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU4" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q58CU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CU4" } ] } ] }, { "uniprot_ac": "Q58DA8", "gene_name": "ZDHHC9", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q58DA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA8" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q58DA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA8" } ] } ] }, { "uniprot_ac": "Q58DT3", "gene_name": "ZDHHC4", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q58DT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q58DT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" }, { "id": "PF01529", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01529" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Palmitoyltransferase DHHC", "eco_id": "ECO_0000259", "start_pos": 137, "end_pos": 269, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.1.225", "ec_name": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "2.3.1.225", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225" }, { "id": "2.3.1.225", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.225" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1H8-1", "uniprot_ac": "A0AAF6Z1H8", "uniprot_id": "A0AAF6Z1H8_BOVIN", "mass": { "chemical_mass": 29471.0, "monoisotopic_mass": 29471.0 }, "refseq": {}, "gene_names": [ { "name": "SRD5A1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ] } ], "protein_names": [ { "name": "3-oxo-5-alpha-steroid 4-dehydrogenase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8/entry#names_and_taxonomy" } ] }, { "name": "1.3.1.22", "type": "synonym", "evidence": [ { "id": "A0AAF6Z1H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8#function" }, { "database": "UniProtKB", "id": "ARBA00037789", "url": "https://www.uniprot.org/uniprotkb/ARBA00037789#function" }, { "database": "UniProtKB", "id": "PIRNR015596", "url": "https://www.uniprot.org/uniprotkb/PIRNR015596#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRD5A1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8", "locus": { "chromosome": "20", "start_pos": 66561436, "end_pos": 66598483, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015478", "url": "https://www.ensembl.org/id/ENSBTAG00000015478" } ] } } ], "crossref": [ { "id": "A0AAF6Z1H8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1H8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10556:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10556:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "21952", "url": "https://www.rhea-db.org/rhea/21952", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50816", "url": "https://www.rhea-db.org/rhea/50816", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50820", "url": "https://www.rhea-db.org/rhea/50820", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "54384", "url": "https://www.rhea-db.org/rhea/54384", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1H8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SPTMELAERFLLDALAYLECALGVVCYVLLKLVGSPYGRYASSGSAFGLPARAAWTVQELPSLALPLLACAGAGAPAERLNRWPNCILLAMFLVHYAQRSLVFPFLIRGGKPMPLYAFLLAFIFCTYNGYLQSRYLSQYAVYADDWLSDPRFLTGSALWLIGMLINIHSDHVLRNLRKPGETGYKIPRGGLFEYISAANYFGEVVEWCGYALASWSIQGWAFAVFTFCVLFTRAQQHHKWYHEKFEDYPKFRKIMIPFLV", "length": 260, "header": "tr|A0AAF6Z1H8-1|A0AAF6Z1H8_BOVIN Isoform 1 of 3-oxo-5-alpha-steroid 4-dehydrogenase OS=Bos taurus OX=9913 GN=SRD5A1 PE=3 SV=1 CANONICAL=A0AAF6Z1H8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z1H8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8/entry", "sequence": { "sequence": "SPTMELAERFLLDALAYLECALGVVCYVLLKLVGSPYGRYASSGSAFGLPARAAWTVQELPSLALPLLACAGAGAPAERLNRWPNCILLAMFLVHYAQRSLVFPFLIRGGKPMPLYAFLLAFIFCTYNGYLQSRYLSQYAVYADDWLSDPRFLTGSALWLIGMLINIHSDHVLRNLRKPGETGYKIPRGGLFEYISAANYFGEVVEWCGYALASWSIQGWAFAVFTFCVLFTRAQQHHKWYHEKFEDYPKFRKIMIPFLV", "length": 260, "header": "tr|A0AAF6Z1H8-1|A0AAF6Z1H8_BOVIN Isoform 1 of 3-oxo-5-alpha-steroid 4-dehydrogenase OS=Bos taurus OX=9913 GN=SRD5A1 PE=3 SV=1 CANONICAL=A0AAF6Z1H8-1" }, "locus": { "chromosome": "20", "start_pos": 66598430, "end_pos": 66563473, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020570.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020570.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020570.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020570.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ], "pmid": "" }, { "name": "androgen biosynthetic process", "id": "GO:0006702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006702", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ], "pmid": "" }, { "name": "sex differentiation", "id": "GO:0007548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007548", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "id": "GO:0047751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047751", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1H8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21952", "name": "", "equation": "5alpha-pregnane-3,20-dione + NADP(+) = progesterone + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z1H8-1", "A5PJS2-1", "E1BJY8-1" ], "evidence": [ { "id": "21952", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21952" } ] }, { "id": "50816", "name": "", "equation": "androst-4-ene-3,17-dione + NADPH + H(+) = 5alpha-androstan-3,17-dione + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z1H8-1", "E1BCQ0-1", "A5PJS2-1" ], "evidence": [ { "id": "50816", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50816" } ] }, { "id": "50820", "name": "", "equation": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z1H8-1", "E1BCQ0-1", "A5PJS2-1", "E1BJY8-1" ], "evidence": [ { "id": "50820", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50820" } ] }, { "id": "54384", "name": "", "equation": "a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z1H8-1", "E1BCQ0-1", "A5PJS2-1", "E1BJY8-1" ], "evidence": [ { "id": "54384", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54384" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z1H8", "gene_name": "SRD5A1", "activity": [ { "ec_number": "1.3.1.22", "activity": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+).", "evidence": [ { "id": "A0AAF6Z1H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ] }, { "ec_number": "1.3.1.22", "activity": "", "evidence": [ { "id": "A0AAF6Z1H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" } ] } ] }, { "uniprot_ac": "A5PJS2", "gene_name": "SRD5A1", "activity": [ { "ec_number": "1.3.1.22", "activity": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+).", "evidence": [ { "id": "A5PJS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJS2" } ] }, { "ec_number": "1.3.1.22", "activity": "", "evidence": [ { "id": "A5PJS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJS2" } ] } ] }, { "uniprot_ac": "E1BCQ0", "gene_name": "SRD5A3", "activity": [ { "ec_number": "1.3.1.22", "activity": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+).", "evidence": [ { "id": "E1BCQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCQ0" } ] }, { "ec_number": "1.3.1.94", "activity": "a di-trans,poly-cis-dolichol + NADP(+) = a di-trans,poly-cis-polyprenol + NADPH + H(+).", "evidence": [ { "id": "E1BCQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCQ0" } ] }, { "ec_number": "1.3.1.22", "activity": "", "evidence": [ { "id": "E1BCQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCQ0" } ] }, { "ec_number": "1.3.1.94", "activity": "", "evidence": [ { "id": "E1BCQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCQ0" } ] } ] }, { "uniprot_ac": "E1BJY8", "gene_name": "SRD5A2", "activity": [ { "ec_number": "1.3.1.22", "activity": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+).", "evidence": [ { "id": "E1BJY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJY8" } ] }, { "ec_number": "1.3.1.22", "activity": "", "evidence": [ { "id": "E1BJY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJY8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z1H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1H8" }, { "id": "PF02544", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02544" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 259, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.3.1.22", "ec_name": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+).", "evidence": [ { "id": "1.3.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22" }, { "id": "1.3.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.1.22" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1S7-1", "uniprot_ac": "A0AAF6Z1S7", "uniprot_id": "A0AAF6Z1S7_BOVIN", "mass": { "chemical_mass": 59413.0, "monoisotopic_mass": 59413.0 }, "refseq": {}, "gene_names": [ { "name": "SMU1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7" } ] } ], "protein_names": [ { "name": "WD40 repeat-containing protein SMU1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7/entry#names_and_taxonomy" } ] }, { "name": "Smu-1 suppressor of mec-8 and unc-52 protein homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6Z1S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in pre-mRNA splicing as a component of the spliceosome. Regulates alternative splicing of the HSPG2 pre-mRNA. Required for normal accumulation of IK. Required for normal mitotic spindle assembly and normal progress through mitosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7#function" }, { "database": "UniProtKB", "id": "ARBA00046199", "url": "https://www.uniprot.org/uniprotkb/ARBA00046199#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMU1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7", "locus": { "chromosome": "8", "start_pos": 74805225, "end_pos": 74834388, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019564", "url": "https://www.ensembl.org/id/ENSBTAG00000019564" } ] } } ], "crossref": [ { "id": "A0AAF6Z1S7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1S7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17814", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17814", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23381", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23381", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSNVREVAGPGVDELRGGSCSREASESVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 532, "header": "tr|A0AAF6Z1S7-1|A0AAF6Z1S7_BOVIN Isoform 1 of WD40 repeat-containing protein SMU1 OS=Bos taurus OX=9913 GN=SMU1 PE=3 SV=1 CANONICAL=A0AAF6Z1S7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z1S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7/entry", "sequence": { "sequence": "MVSNVREVAGPGVDELRGGSCSREASESVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 532, "header": "tr|A0AAF6Z1S7-1|A0AAF6Z1S7_BOVIN Isoform 1 of WD40 repeat-containing protein SMU1 OS=Bos taurus OX=9913 GN=SMU1 PE=3 SV=1 CANONICAL=A0AAF6Z1S7-1" }, "locus": { "chromosome": "8", "start_pos": 74834177, "end_pos": 74805636, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020865.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020865.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020865.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020865.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z1S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1S7" }, { "id": "PS50897", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50897" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTLH", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 111, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 436, "end_pos": 438 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1X8-1", "uniprot_ac": "A0AAF6Z1X8", "uniprot_id": "A0AAF6Z1X8_BOVIN", "mass": { "chemical_mass": 27327.0, "monoisotopic_mass": 27327.0 }, "refseq": {}, "gene_names": [ { "name": "TFPI2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8" } ] } ], "protein_names": [ { "name": "Tissue factor pathway inhibitor", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8#function" }, { "database": "UniProtKB", "id": "ARBA00060238", "url": "https://www.uniprot.org/uniprotkb/ARBA00060238#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TFPI2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8", "locus": { "chromosome": "4", "start_pos": 11204089, "end_pos": 11208397, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015844", "url": "https://www.ensembl.org/id/ENSBTAG00000015844" } ] } } ], "crossref": [ { "id": "A0AAF6Z1X8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1X8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22615", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22615", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22616", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22616", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSVRPLWLMLLSLLLVGTALGDASQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCKKFISGGCHSNENRFPDEATCMDFCAPKRGKYSLCAPVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYTGCGGNDNNFVNLKDCKRTCVKALKKEKNKKMPRLLLANRRLKIKKKQF", "length": 240, "header": "tr|A0AAF6Z1X8-1|A0AAF6Z1X8_BOVIN Isoform 1 of Tissue factor pathway inhibitor OS=Bos taurus OX=9913 GN=TFPI2 PE=4 SV=1 CANONICAL=A0AAF6Z1X8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z1X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8/entry", "sequence": { "sequence": "MDSVRPLWLMLLSLLLVGTALGDASQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCKKFISGGCHSNENRFPDEATCMDFCAPKRGKYSLCAPVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYTGCGGNDNNFVNLKDCKRTCVKALKKEKNKKMPRLLLANRRLKIKKKQF", "length": 240, "header": "tr|A0AAF6Z1X8-1|A0AAF6Z1X8_BOVIN Isoform 1 of Tissue factor pathway inhibitor OS=Bos taurus OX=9913 GN=TFPI2 PE=4 SV=1 CANONICAL=A0AAF6Z1X8-1" }, "locus": { "chromosome": "4", "start_pos": 11208325, "end_pos": 11204639, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021062.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021062.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021062.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021062.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1X8" }, { "id": "PS50279", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50279" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BPTI/Kunitz inhibitor", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 86, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 190, "end_pos": 192 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZWY7-1", "uniprot_ac": "A0AAF6ZWY7", "uniprot_id": "A0AAF6ZWY7_BOVIN", "mass": { "chemical_mass": 42191.0, "monoisotopic_mass": 42191.0 }, "refseq": {}, "gene_names": [ { "name": "RHNO1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZWY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7" } ] } ], "protein_names": [ { "name": "RAD9-HUS1-RAD1 interacting nuclear orphan 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZWY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWY7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHNO1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7", "locus": { "chromosome": "5", "start_pos": 106876984, "end_pos": 106886915, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015878", "url": "https://www.ensembl.org/id/ENSBTAG00000015878" } ] } } ], "crossref": [ { "id": "A0AAF6ZWY7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZWY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR35541", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35541", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35541:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35541:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15319", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15319", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z1Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZWY7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZWY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VGAREAGCSSTAHCRQSPATPWPEPALRARRPRASSQSPTHLAAPSVPGGSALLRPAGLTETPAAGRGIPGSRRGRGGGGRVSQARAGGGVPLWGFQFVPLFEIGAGGALRSRDERDQSASALYPRSAGTPAAGGAPGREGGRGGRIGGGGGGTGRKKRRQAAQKPQLLFHQQPLEAPKHRCRFPQLPVVTHTRQVPSKPVDHNTITSWVSPQFDTTAESWFPGKRKHHHRDHARRSSRKSTSSRFPCLTFETPQSSASSATPGILASRDGPSQPEKDISGRPLVPMLSPQSCRELSAHTFPDFPCVFIPPDIQTPESPGQGEPIPSELRENSLPSCSLHTSTPKSPEPGPVLVTDTPEEKYGIKVTWRRRRHLFAYLRERGKLSRSQFLVKD", "length": 393, "header": "tr|A0AAF6ZWY7-1|A0AAF6ZWY7_BOVIN Isoform 1 of RAD9-HUS1-RAD1 interacting nuclear orphan 1 OS=Bos taurus OX=9913 GN=RHNO1 PE=4 SV=1 CANONICAL=A0AAF6ZWY7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z1Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Y0/entry", "sequence": { "sequence": "GRKKRRQAAQKPQLLFHQQPLEAPKHRCRFPQLPVVTHTRQVPSKPVDHNTITSWVSPQFDTTAESWFPGKRKHHHRDHARRSSRKSTSSRFPCLTFETPQSSASSATPGILASRDGPSQPEKDISGRPLVPMLSPQSCRELSAHTFPDFPCVFIPPDIQTPESPGQGEPIPSELRENSLPSCSLHTSTPKSPEPGPVLVTDTPEEKYGIKVTWRRRRHLFAYLRERGKLSRSQFLVKD", "length": 239, "header": "tr|A0AAF6Z1Y0-1|A0AAF6ZWY7_BOVIN Computationally mapped isoform of RAD9-HUS1-RAD1 interacting nuclear orphan 1 OS=Bos taurus OX=9913 GN=RHNO1 PE=4 SV=1 CANONICAL=A0AAF6ZWY7-1" }, "locus": { "chromosome": "5", "start_pos": 106886358, "end_pos": 106877656, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021104.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021104.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021104.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021104.3" } ] } }, { "isoform_ac": "A0AAF6ZWY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7/entry", "sequence": { "sequence": "VGAREAGCSSTAHCRQSPATPWPEPALRARRPRASSQSPTHLAAPSVPGGSALLRPAGLTETPAAGRGIPGSRRGRGGGGRVSQARAGGGVPLWGFQFVPLFEIGAGGALRSRDERDQSASALYPRSAGTPAAGGAPGREGGRGGRIGGGGGGTGRKKRRQAAQKPQLLFHQQPLEAPKHRCRFPQLPVVTHTRQVPSKPVDHNTITSWVSPQFDTTAESWFPGKRKHHHRDHARRSSRKSTSSRFPCLTFETPQSSASSATPGILASRDGPSQPEKDISGRPLVPMLSPQSCRELSAHTFPDFPCVFIPPDIQTPESPGQGEPIPSELRENSLPSCSLHTSTPKSPEPGPVLVTDTPEEKYGIKVTWRRRRHLFAYLRERGKLSRSQFLVKD", "length": 393, "header": "tr|A0AAF6ZWY7-1|A0AAF6ZWY7_BOVIN Isoform 1 of RAD9-HUS1-RAD1 interacting nuclear orphan 1 OS=Bos taurus OX=9913 GN=RHNO1 PE=4 SV=1 CANONICAL=A0AAF6ZWY7-1" }, "locus": { "chromosome": "5", "start_pos": 106886913, "end_pos": 106877656, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068838.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068838.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059471.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059471.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 262, "start_aa": "Thr", "end_pos": 262, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr262", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWY7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWY7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWY7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 262 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z1Z8-1", "uniprot_ac": "A0AAF6Z1Z8", "uniprot_id": "A0AAF6Z1Z8_BOVIN", "mass": { "chemical_mass": 24262.0, "monoisotopic_mass": 24262.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM147", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ] } ], "protein_names": [ { "name": "BOS complex subunit TMEM147", "type": "recommended", "evidence": [ { "id": "A0AAF6Z1Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 147", "type": "synonym", "evidence": [ { "id": "A0AAF6Z1Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8#function" }, { "database": "UniProtKB", "id": "ARBA00045811", "url": "https://www.uniprot.org/uniprotkb/ARBA00045811#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM147", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8", "locus": { "chromosome": "18", "start_pos": 46207471, "end_pos": 46204657, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015920", "url": "https://www.ensembl.org/id/ENSBTAG00000015920" } ] } } ], "crossref": [ { "id": "A0AAF6Z1Z8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z1Z8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12869:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12869:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09767", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09767", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTYRPAVLLLMFLSVYKAFVMDWTALLARALVTGLLALSTLALYVAVVNVHS", "length": 214, "header": "tr|A0AAF6Z1Z8-1|A0AAF6Z1Z8_BOVIN Isoform 1 of BOS complex subunit TMEM147 OS=Bos taurus OX=9913 GN=TMEM147 PE=3 SV=1 CANONICAL=A0AAF6Z1Z8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z1Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8/entry", "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTYRPAVLLLMFLSVYKAFVMDWTALLARALVTGLLALSTLALYVAVVNVHS", "length": 214, "header": "tr|A0AAF6Z1Z8-1|A0AAF6Z1Z8_BOVIN Isoform 1 of BOS complex subunit TMEM147 OS=Bos taurus OX=9913 GN=TMEM147 PE=3 SV=1 CANONICAL=A0AAF6Z1Z8-1" }, "locus": { "chromosome": "18", "start_pos": 46206467, "end_pos": 46204765, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021170.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021170.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021170.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021170.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" }, { "name": "multi-pass translocon complex", "id": "GO:0160064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160064", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to nuclear inner membrane", "id": "GO:0036228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036228", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" }, { "name": "multi-pass transmembrane protein insertion into ER membrane", "id": "GO:0160063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160063", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z1Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1Z8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z202-1", "uniprot_ac": "A0AAF6Z202", "uniprot_id": "A0AAF6Z202_BOVIN", "mass": { "chemical_mass": 44104.0, "monoisotopic_mass": 44104.0 }, "refseq": { "ac": "XP_005219028", "name": "glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219028" }, "gene_names": [ { "name": "GAPDHS", "type": "recommended", "evidence": [ { "id": "A0AAF6Z202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ] }, { "name": "GAPDHS", "type": "synonym", "evidence": [ { "id": "XP_005219028", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219028" } ] } ], "protein_names": [ { "name": "Glyceraldehyde-3-phosphate dehydrogenase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202/entry#names_and_taxonomy" } ] }, { "name": "1.2.1.12", "type": "synonym", "evidence": [ { "id": "A0AAF6Z202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202/entry#names_and_taxonomy" } ] }, { "name": "glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005219028", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219028" } ] } ], "function": [ { "annotation": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis. May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202#function" }, { "database": "UniProtKB", "id": "ARBA00094185", "url": "https://www.uniprot.org/uniprotkb/ARBA00094185#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAPDHS", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202", "locus": { "chromosome": "18", "start_pos": 46204429, "end_pos": 46195508, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015917", "url": "https://www.ensembl.org/id/ENSBTAG00000015917" } ] } } ], "crossref": [ { "id": "A0AAF6Z202", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z202", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18126", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18126", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532231", "url": "https://www.ncbi.nlm.nih.gov/gene/532231", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10836:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10836:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00044", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00044", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02800", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02800", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005219028", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219028", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10300", "url": "https://www.rhea-db.org/rhea/10300", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66684", "url": "https://www.rhea-db.org/rhea/66684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z202-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPRVEAEPEPPAQPQPQPEPIKEEVPPPPPPPPAPKKVRELIVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDLEYMVYMFKYDSTHGRYKGNVEHKKGQLVVDNNEISVFQCKQPKEIPWKSVGSPFVVEATGVYLSLEETKAHIEAGAQRVVICAPSPDAPMFVMGVNEKEYNPSSMKIVSNASCTTNCLAPLAKVIHERFGILEGLMTTVHSYTATQKTVDGPSKKAWRDGRGAHQNIIPASTGAAKAVGKVIPDLKGKLTGMAFRVPTPDVSVVDLTCRLAQPTPYSAIKDAIKAAAKGPMAGILAYTEDEVVSTDFLSDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSNRVVDLVRYMFSRDK", "length": 403, "header": "tr|A0AAF6Z202-1|A0AAF6Z202_BOVIN Isoform 1 of Glyceraldehyde-3-phosphate dehydrogenase OS=Bos taurus OX=9913 GN=GAPDHS PE=3 SV=1 CANONICAL=A0AAF6Z202-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z202-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202/entry", "sequence": { "sequence": "MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPRVEAEPEPPAQPQPQPEPIKEEVPPPPPPPPAPKKVRELIVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDLEYMVYMFKYDSTHGRYKGNVEHKKGQLVVDNNEISVFQCKQPKEIPWKSVGSPFVVEATGVYLSLEETKAHIEAGAQRVVICAPSPDAPMFVMGVNEKEYNPSSMKIVSNASCTTNCLAPLAKVIHERFGILEGLMTTVHSYTATQKTVDGPSKKAWRDGRGAHQNIIPASTGAAKAVGKVIPDLKGKLTGMAFRVPTPDVSVVDLTCRLAQPTPYSAIKDAIKAAAKGPMAGILAYTEDEVVSTDFLSDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSNRVVDLVRYMFSRDK", "length": 403, "header": "tr|A0AAF6Z202-1|A0AAF6Z202_BOVIN Isoform 1 of Glyceraldehyde-3-phosphate dehydrogenase OS=Bos taurus OX=9913 GN=GAPDHS PE=3 SV=1 CANONICAL=A0AAF6Z202-1" }, "locus": { "chromosome": "18", "start_pos": 46204276, "end_pos": 46195606, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021166.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021166.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021166.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021166.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "pmid": "" }, { "name": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "id": "GO:0004365", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004365", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "pmid": "" }, { "name": "NADP binding", "id": "GO:0050661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050661", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glucose metabolic process", "id": "GO:0006006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006006", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z202", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10300", "name": "", "equation": "D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z202-1", "P10096-1", "Q2KJE5-1" ], "evidence": [ { "id": "10300", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10300" } ] }, { "id": "66684", "name": "", "equation": "S-nitroso-L-cysteinyl-[GAPDH] + L-cysteinyl-[protein] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10096-1", "A0AAF6Z202-1" ], "evidence": [ { "id": "66684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66684" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z202", "gene_name": "GAPDHS", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+).", "evidence": [ { "id": "A0AAF6Z202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "A0AAF6Z202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" } ] } ] }, { "uniprot_ac": "P10096", "gene_name": "GAPDH", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+).", "evidence": [ { "id": "P10096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10096" } ] }, { "ec_number": "2.6.99.-", "activity": "", "evidence": [ { "id": "P10096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10096" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "P10096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10096" } ] } ] }, { "uniprot_ac": "Q2KJE5", "gene_name": "GAPDHS", "activity": [ { "ec_number": "1.2.1.12", "activity": "D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+).", "evidence": [ { "id": "Q2KJE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJE5" } ] }, { "ec_number": "1.2.1.12", "activity": "", "evidence": [ { "id": "Q2KJE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJE5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z202" }, { "id": "SM00846", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00846" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 219, "start_aa": "Leu", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.2.1.12", "ec_name": "D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+).", "evidence": [ { "id": "1.2.1.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12" }, { "id": "1.2.1.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.12" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 216, "end_pos": 218 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z211-1", "uniprot_ac": "A0AAF6Z211", "uniprot_id": "A0AAF6Z211_BOVIN", "mass": { "chemical_mass": 80481.0, "monoisotopic_mass": 80481.0 }, "refseq": {}, "gene_names": [ { "name": "NOL11", "type": "recommended", "evidence": [ { "id": "A0AAF6Z211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" } ] } ], "protein_names": [ { "name": "Nucleolar protein 11", "type": "synonym", "evidence": [ { "id": "A0AAF6Z211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z211", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOL11", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211", "locus": { "chromosome": "19", "start_pos": 49176026, "end_pos": 49194712, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015951", "url": "https://www.ensembl.org/id/ENSBTAG00000015951" } ] } } ], "crossref": [ { "id": "A0AAF6Z211", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z211", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR012584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15633", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15633", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15633:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15633:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20998", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20998", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z211", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z211-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADLEEGFALTAVPLGSGPDGPLGVEQSGKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYIVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRIHSIQGTEPLVLFKEGAVRGLEALLAEPQQKIETVISDEEVIKWTKFFMVFRHPVLIFITEKHGNYFVYVQKFNSRILSKYTLLLGQEEKCVIQSFSTSVGRKFISLMSLSSDGCVYETLIPIHPSEPEKNQRLVQSQLLKSVVSGSARNGVALAILDQDHIAVLGAPLPASKECLSVWNTKFQTLQTSKELPQGTSGQLWYYGENLFMLHGKFLTVVPFKCEVSSLAGALGKLKHSQDPGIHATPHFVNWETSQGCGLGSQNSEQSKRILRRRKVEVSVQPEVPASTQLLATIQKDSEKHIEVELRKFLATKRTPDFHTIIGDVIIGLLGRCKAEPSFYPCNCLMQLVQTHVLSYSLCPGLMEFALEKTDVQILQLCLQQFPDIPESVTCACLKVFLSIGDDTLQDTDINMESVSDYMDPVQDGEMEEQTAFLQNGFSPEEDNCDSCAQKLKEKPQAAADESTSCPVTPKRAALFRNAVLHSAYSETFLLPHLKDIPAQHSTLFLQYLYFLYLKCSENATMTLPGTHPPTLSQIMDWICLLLDANFTVVVMIPEAKRLLLSLYKFVKSQISICSELNKIEVSFRELQKLNQEKNNRELYSIEVLELF", "length": 719, "header": "tr|A0AAF6Z211-1|A0AAF6Z211_BOVIN Isoform 1 of Nucleolar protein 11 OS=Bos taurus OX=9913 GN=NOL11 PE=4 SV=1 CANONICAL=A0AAF6Z211-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z211-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211/entry", "sequence": { "sequence": "MADLEEGFALTAVPLGSGPDGPLGVEQSGKTDQFLVTDSGRTVILYKVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYIVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRIHSIQGTEPLVLFKEGAVRGLEALLAEPQQKIETVISDEEVIKWTKFFMVFRHPVLIFITEKHGNYFVYVQKFNSRILSKYTLLLGQEEKCVIQSFSTSVGRKFISLMSLSSDGCVYETLIPIHPSEPEKNQRLVQSQLLKSVVSGSARNGVALAILDQDHIAVLGAPLPASKECLSVWNTKFQTLQTSKELPQGTSGQLWYYGENLFMLHGKFLTVVPFKCEVSSLAGALGKLKHSQDPGIHATPHFVNWETSQGCGLGSQNSEQSKRILRRRKVEVSVQPEVPASTQLLATIQKDSEKHIEVELRKFLATKRTPDFHTIIGDVIIGLLGRCKAEPSFYPCNCLMQLVQTHVLSYSLCPGLMEFALEKTDVQILQLCLQQFPDIPESVTCACLKVFLSIGDDTLQDTDINMESVSDYMDPVQDGEMEEQTAFLQNGFSPEEDNCDSCAQKLKEKPQAAADESTSCPVTPKRAALFRNAVLHSAYSETFLLPHLKDIPAQHSTLFLQYLYFLYLKCSENATMTLPGTHPPTLSQIMDWICLLLDANFTVVVMIPEAKRLLLSLYKFVKSQISICSELNKIEVSFRELQKLNQEKNNRELYSIEVLELF", "length": 719, "header": "tr|A0AAF6Z211-1|A0AAF6Z211_BOVIN Isoform 1 of Nucleolar protein 11 OS=Bos taurus OX=9913 GN=NOL11 PE=4 SV=1 CANONICAL=A0AAF6Z211-1" }, "locus": { "chromosome": "19", "start_pos": 49194699, "end_pos": 49176323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021210.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021210.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021210.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021210.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z211", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" } ], "pmid": "" }, { "name": "positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "id": "GO:1901838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901838", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z211", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA", "id": "GO:0030490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030490", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z211", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "t-UTP complex", "id": "GO:0034455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034455", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z211", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" }, { "start_pos": 657, "end_pos": 659, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" }, { "id": "PF20998", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20998" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolar protein 11 C-terminal", "eco_id": "ECO_0000259", "start_pos": 399, "end_pos": 719, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z211" }, { "id": "PF08168", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08168" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolar protein 11 N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 332, "start_aa": "Met", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 630, "end_pos": 632 }, { "start_pos": 657, "end_pos": 659 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z257-1", "uniprot_ac": "A0AAF6Z257", "uniprot_id": "A0AAF6Z257_BOVIN", "mass": { "chemical_mass": 81891.0, "monoisotopic_mass": 81891.0 }, "refseq": {}, "gene_names": [ { "name": "IRAK1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ], "protein_names": [ { "name": "Interleukin-1 receptor-associated kinase 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IRAK1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257", "locus": { "chromosome": "X", "start_pos": 37212344, "end_pos": 37220146, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016085", "url": "https://www.ensembl.org/id/ENSBTAG00000016085" } ] } } ], "crossref": [ { "id": "A0AAF6Z257", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z257", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08794", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08794", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR27001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR27001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR27001:SF939", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR27001:SF939", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00531", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00531", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z257-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGGPGPGDPAVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVRILTHLQLLRARDIITAWHPPAPLLPPSTTSLTPSSISAPSEAAVPGHRKLPSLASTFLSPAFPGSQTHSDPELCPGPSPAAHQPPLPSPAPSSTKPSPESPMSLLPGAPSSSFCWPLHEICQGTHDFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKEEADLEWTTVKQSFQTEVQQLSRFRHPNIVDFAGYCAQSGFYCLVYGFLPNGSLEDRLHVQTQAWPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDVKSSNVLLDERLMPKLGDFGLARLSRFTGANPGQSSSVARTRTVRGTLAYLPEEYVKTGRLAVDTDTFSFGVVLLETLAGQRAVRMHGAQPKYLKDLVEEEAEEAGVTLKGTQTAVQGGPAADTWAALVAAQIYKKHLDPRPGPCPPQLGLALGQLACCCLHRRAKRRPPMTQVYQTLEELQVVVAGPCLELEAASRSPPSPQENSYVSTSGSALSRASPWQPLAAPLGAQAQATDWPQKGANQPVESDESVSDLSAALHSWHLSPSCPAGPGAPSWVPAPFGQAACTQGGAARESSCGSGPGLQPTAVEGPLLGSSMSSRPPQIVINPARRKMLQKLALLGPGPSGQAGARRERRVSELNRPPGPIPKPGSPSSHGRKFSWPSTPWQPMGIGGGGTPSAWRRVCGGPGTCGVWAWAGLGAPRPE", "length": 765, "header": "tr|A0AAF6Z257-1|A0AAF6Z257_BOVIN Isoform 1 of Interleukin-1 receptor-associated kinase 1 OS=Bos taurus OX=9913 GN=IRAK1 PE=3 SV=1 CANONICAL=A0AAF6Z257-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z257-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257/entry", "sequence": { "sequence": "MAGGPGPGDPAVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVRILTHLQLLRARDIITAWHPPAPLLPPSTTSLTPSSISAPSEAAVPGHRKLPSLASTFLSPAFPGSQTHSDPELCPGPSPAAHQPPLPSPAPSSTKPSPESPMSLLPGAPSSSFCWPLHEICQGTHDFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKEEADLEWTTVKQSFQTEVQQLSRFRHPNIVDFAGYCAQSGFYCLVYGFLPNGSLEDRLHVQTQAWPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDVKSSNVLLDERLMPKLGDFGLARLSRFTGANPGQSSSVARTRTVRGTLAYLPEEYVKTGRLAVDTDTFSFGVVLLETLAGQRAVRMHGAQPKYLKDLVEEEAEEAGVTLKGTQTAVQGGPAADTWAALVAAQIYKKHLDPRPGPCPPQLGLALGQLACCCLHRRAKRRPPMTQVYQTLEELQVVVAGPCLELEAASRSPPSPQENSYVSTSGSALSRASPWQPLAAPLGAQAQATDWPQKGANQPVESDESVSDLSAALHSWHLSPSCPAGPGAPSWVPAPFGQAACTQGGAARESSCGSGPGLQPTAVEGPLLGSSMSSRPPQIVINPARRKMLQKLALLGPGPSGQAGARRERRVSELNRPPGPIPKPGSPSSHGRKFSWPSTPWQPMGIGGGGTPSAWRRVCGGPGTCGVWAWAGLGAPRPE", "length": 765, "header": "tr|A0AAF6Z257-1|A0AAF6Z257_BOVIN Isoform 1 of Interleukin-1 receptor-associated kinase 1 OS=Bos taurus OX=9913 GN=IRAK1 PE=3 SV=1 CANONICAL=A0AAF6Z257-1" }, "locus": { "chromosome": "X", "start_pos": 37220133, "end_pos": 37213348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021407.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021407.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021407.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021407.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 737, "start_aa": "Thr", "end_pos": 737, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr737", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "interleukin-1-mediated signaling pathway", "id": "GO:0070498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070498", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "positive regulation of leukocyte adhesion to vascular endothelial cell", "id": "GO:1904996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904996", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "type I interferon-mediated signaling pathway", "id": "GO:0060337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060337", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "canonical NF-kappaB signal transduction", "id": "GO:0007249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "lipopolysaccharide-mediated signaling pathway", "id": "GO:0031663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031663", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "regulation of cytokine-mediated signaling pathway", "id": "GO:0001959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001959", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "positive regulation of intracellular signal transduction", "id": "GO:1902533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902533", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "toll-like receptor 2 signaling pathway", "id": "GO:0034134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034134", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "interleukin-33-mediated signaling pathway", "id": "GO:0038172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038172", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z257", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 521, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 737 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 293, "end_pos": 295 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z268-1", "uniprot_ac": "A0AAF6Z268", "uniprot_id": "A0AAF6Z268_BOVIN", "mass": { "chemical_mass": 33059.0, "monoisotopic_mass": 33059.0 }, "refseq": {}, "gene_names": [ { "name": "HEY1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ] } ], "protein_names": [ { "name": "Hes related family bHLH transcription factor with YRPW motif 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEY1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268", "locus": { "chromosome": "14", "start_pos": 42969172, "end_pos": 42972066, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015717", "url": "https://www.ensembl.org/id/ENSBTAG00000015717" } ] } } ], "crossref": [ { "id": "A0AAF6Z268", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z268", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z268-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRAHPEYSSSESELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEKGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGSAFGHHPHVAHPLLLSQSTHGNTGTSASPTESHHQGRLATAHPEASALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF", "length": 308, "header": "tr|A0AAF6Z268-1|A0AAF6Z268_BOVIN Isoform 1 of Hes related family bHLH transcription factor with YRPW motif 1 OS=Bos taurus OX=9913 GN=HEY1 PE=3 SV=1 CANONICAL=A0AAF6Z268-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z268-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268/entry", "sequence": { "sequence": "MKRAHPEYSSSESELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEKGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGSAFGHHPHVAHPLLLSQSTHGNTGTSASPTESHHQGRLATAHPEASALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF", "length": 308, "header": "tr|A0AAF6Z268-1|A0AAF6Z268_BOVIN Isoform 1 of Hes related family bHLH transcription factor with YRPW motif 1 OS=Bos taurus OX=9913 GN=HEY1 PE=3 SV=1 CANONICAL=A0AAF6Z268-1" }, "locus": { "chromosome": "14", "start_pos": 42971942, "end_pos": 42969438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020864.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020864.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020864.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020864.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell differentiation", "id": "GO:0051151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051151", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z268", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 108, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z268" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 162, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 31, "end_pos": 33 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z274-1", "uniprot_ac": "A0AAF6Z274", "uniprot_id": "A0AAF6Z274_BOVIN", "mass": { "chemical_mass": 52251.0, "monoisotopic_mass": 52251.0 }, "refseq": { "ac": "XP_005223306", "name": "protein kinase C and casein kinase substrate in neurons protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223306" }, "gene_names": [ { "name": "PACSIN1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ] }, { "name": "PACSIN1", "type": "synonym", "evidence": [ { "id": "XP_005223306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223306" } ] } ], "protein_names": [ { "name": "Protein kinase C and casein kinase substrate in neurons protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274/entry#names_and_taxonomy" } ] }, { "name": "protein kinase C and casein kinase substrate in neurons protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223306" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PACSIN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274", "locus": { "chromosome": "23", "start_pos": 8588638, "end_pos": 8523678, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016124", "url": "https://www.ensembl.org/id/ENSBTAG00000016124" } ] } } ], "crossref": [ { "id": "A0AAF6Z274", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z274", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07680", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07680", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11998", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11998", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520488", "url": "https://www.ncbi.nlm.nih.gov/gene/520488", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23065", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23065", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23065:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23065:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00611", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00611", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005223306", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223306", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z274-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNATTHLSTAPPRTMSGSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLLEKGPQYGSLERAWGAIMTEADKVSELHQEMKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAVTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLDDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAESSSYVQVYRELEQAIRGADAQDDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTAAKKEKQPKKAEGAALTNAAGVVESTSQAGDRGSVSSYDRGQTYATEWSDDESGNPFGGSEANGGSNPFDEDAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEVV", "length": 459, "header": "tr|A0AAF6Z274-1|A0AAF6Z274_BOVIN Isoform 1 of Protein kinase C and casein kinase substrate in neurons protein 1 OS=Bos taurus OX=9913 GN=PACSIN1 PE=3 SV=1 CANONICAL=A0AAF6Z274-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z274-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274/entry", "sequence": { "sequence": "MLNATTHLSTAPPRTMSGSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLLEKGPQYGSLERAWGAIMTEADKVSELHQEMKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAVTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLDDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAESSSYVQVYRELEQAIRGADAQDDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTAAKKEKQPKKAEGAALTNAAGVVESTSQAGDRGSVSSYDRGQTYATEWSDDESGNPFGGSEANGGSNPFDEDAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEVV", "length": 459, "header": "tr|A0AAF6Z274-1|A0AAF6Z274_BOVIN Isoform 1 of Protein kinase C and casein kinase substrate in neurons protein 1 OS=Bos taurus OX=9913 GN=PACSIN1 PE=3 SV=1 CANONICAL=A0AAF6Z274-1" }, "locus": { "chromosome": "23", "start_pos": 8586044, "end_pos": 8580054, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021459.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021459.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021459.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021459.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "cytoskeletal protein binding", "id": "GO:0008092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "COPI-coated vesicle", "id": "GO:0030137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030137", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "presynaptic endocytic zone", "id": "GO:0098833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098833", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "photoreceptor ribbon synapse", "id": "GO:0098684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098684", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "plasma membrane tubulation", "id": "GO:0097320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097320", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" }, { "name": "synaptic vesicle endocytosis", "id": "GO:0048488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048488", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z274", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" }, { "id": "PS51741", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51741" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-BAR", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 298, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z274" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 400, "end_pos": 459, "start_aa": "Ala", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z344-1", "uniprot_ac": "A0AAF6Z344", "uniprot_id": "A0AAF6Z344_BOVIN", "mass": { "chemical_mass": 39292.0, "monoisotopic_mass": 39292.0 }, "refseq": {}, "gene_names": [ { "name": "OSER1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344" } ] } ], "protein_names": [ { "name": "Oxidative stress-responsive serine-rich protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344/entry#names_and_taxonomy" } ] }, { "name": "Oxidative stress-responsive protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344/entry#names_and_taxonomy" } ] }, { "name": "Peroxide-inducible transcript 1 protein", "type": "synonym", "evidence": [ { "id": "A0AAF6Z344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z344", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OSER1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344", "locus": { "chromosome": "13", "start_pos": 72669119, "end_pos": 72679486, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016873", "url": "https://www.ensembl.org/id/ENSBTAG00000016873" } ] } } ], "crossref": [ { "id": "A0AAF6Z344", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z344", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31383:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31383:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z344", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z344-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ARK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ARK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ARK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ARK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGEREGGGARAWVTQAQCDFGGAGRPSADLDPGQSGAAIWERRSKLTGLAYRSAPAARSINGNIHNSVKTFTMKSEAKDGEEESLQTAFKKLRVDASGSIASLSVGEGASVRASVRAAVEDAKPKSACASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSQLKHKSQTDSPDGSSGLGISTPKEFNAGECSSSLDTNHTGAVAEPLRTSVPRLPSESKEEDSSDAPQVSQASLQANDLSDFQSVSKLNLGKPCVCIGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSTLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 364, "header": "tr|A0AAF6Z344-1|A0AAF6Z344_BOVIN Isoform 1 of Oxidative stress-responsive serine-rich protein 1 OS=Bos taurus OX=9913 GN=OSER1 PE=4 SV=1 CANONICAL=A0AAF6Z344-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z344-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344/entry", "sequence": { "sequence": "MGGEREGGGARAWVTQAQCDFGGAGRPSADLDPGQSGAAIWERRSKLTGLAYRSAPAARSINGNIHNSVKTFTMKSEAKDGEEESLQTAFKKLRVDASGSIASLSVGEGASVRASVRAAVEDAKPKSACASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSQLKHKSQTDSPDGSSGLGISTPKEFNAGECSSSLDTNHTGAVAEPLRTSVPRLPSESKEEDSSDAPQVSQASLQANDLSDFQSVSKLNLGKPCVCIGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSTLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 364, "header": "tr|A0AAF6Z344-1|A0AAF6Z344_BOVIN Isoform 1 of Oxidative stress-responsive serine-rich protein 1 OS=Bos taurus OX=9913 GN=OSER1 PE=4 SV=1 CANONICAL=A0AAF6Z344-1" }, "locus": { "chromosome": "13", "start_pos": 72679287, "end_pos": 72669657, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022448.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022448.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022448.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022448.3" } ] } }, { "isoform_ac": "A0AAF7ARK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ARK7/entry", "sequence": { "sequence": "ECKGSIASLSVGEGASVRASVRAAVEDAKPKSACASKDSWHGSTRKSSRGAVRTQRRRRSKSPVLHPPKFIHCSTIASSSSQLKHKSQTDSPDGSSGLGISTPKEFNAGECSSSLDTNHTGAVAEPLRTSVPRLPSESKEEDSSDAPQVSQASLQANDLSDFQSVSKLNLGKPCVCIGKECQCKRWHDMEVYSFSGLQNVPPLAPERRSTLEDYSQSLHTRTLSGSPRSCSEQARVYVDDVTIEDLSGYMEYYLYIPKKMSHMAEMMYT", "length": 269, "header": "tr|A0AAF7ARK7-1|A0AAF7ARK7_BOVIN Computationally mapped isoform of Oxidative stress-responsive serine-rich protein 1 OS=Bos taurus OX=9913 GN=OSER1 PE=4 SV=1 CANONICAL=A0AAF6Z344-1" }, "locus": { "chromosome": "13", "start_pos": 72673754, "end_pos": 72669657, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082229.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082229.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073345.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073345.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z344", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z344" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z3C8-1", "uniprot_ac": "A0AAF6Z3C8", "uniprot_id": "A0AAF6Z3C8_BOVIN", "mass": { "chemical_mass": 29206.0, "monoisotopic_mass": 29206.0 }, "refseq": {}, "gene_names": [ { "name": "MMACHC", "type": "recommended", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ] } ], "protein_names": [ { "name": "Cyanocobalamin reductase / alkylcobalamin dealkylase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] }, { "name": "1.16.1.6", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.151", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] }, { "name": "Alkylcobalamin:glutathione S-alkyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] }, { "name": "CblC", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] }, { "name": "Cyanocobalamin reductase (cyanide-eliminating)", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] }, { "name": "Methylmalonic aciduria and homocystinuria type C protein", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MMACHC", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8", "locus": { "chromosome": "3", "start_pos": 100566182, "end_pos": 100571034, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017027", "url": "https://www.ensembl.org/id/ENSBTAG00000017027" } ] } } ], "crossref": [ { "id": "A0AAF6Z3C8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z3C8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12959", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12959", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR032037", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032037", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31457", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31457", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31457:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31457:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16113", "url": "https://www.rhea-db.org/rhea/16113", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40719", "url": "https://www.rhea-db.org/rhea/40719", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63132", "url": "https://www.rhea-db.org/rhea/63132", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63136", "url": "https://www.rhea-db.org/rhea/63136", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRAALQVAWYNALLPPAFHLPLPGPTLAFLVLSTPAMFDQALKPFLQSHHLQPLTDPVDQCVAYHLGRVRESLPELQIEVIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVESDPWGTQHIAGVCIHPRFGGWFAIRGVVLLRGTEVPNLPPTKPVDCVPTRADRISLLERFNFHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLLQPSEEPSSPSQELHITTLLSKKPQNPRRGWLSPTVSPPISPGP", "length": 260, "header": "tr|A0AAF6Z3C8-1|A0AAF6Z3C8_BOVIN Isoform 1 of Cyanocobalamin reductase / alkylcobalamin dealkylase OS=Bos taurus OX=9913 GN=MMACHC PE=3 SV=1 CANONICAL=A0AAF6Z3C8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z3C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8/entry", "sequence": { "sequence": "MGRAALQVAWYNALLPPAFHLPLPGPTLAFLVLSTPAMFDQALKPFLQSHHLQPLTDPVDQCVAYHLGRVRESLPELQIEVIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVESDPWGTQHIAGVCIHPRFGGWFAIRGVVLLRGTEVPNLPPTKPVDCVPTRADRISLLERFNFHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLLQPSEEPSSPSQELHITTLLSKKPQNPRRGWLSPTVSPPISPGP", "length": 260, "header": "tr|A0AAF6Z3C8-1|A0AAF6Z3C8_BOVIN Isoform 1 of Cyanocobalamin reductase / alkylcobalamin dealkylase OS=Bos taurus OX=9913 GN=MMACHC PE=3 SV=1 CANONICAL=A0AAF6Z3C8-1" }, "locus": { "chromosome": "3", "start_pos": 100570835, "end_pos": 100566549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022638.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022638.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022638.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022638.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "glutathione binding", "id": "GO:0043295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043295", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "demethylase activity", "id": "GO:0032451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032451", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "cobalamin binding", "id": "GO:0031419", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031419", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity", "id": "GO:0033787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033787", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cobalamin metabolic process", "id": "GO:0009235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009235", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "demethylation", "id": "GO:0070988", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070988", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" }, { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3C8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16113", "name": "", "equation": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 cyanocob(III)alamin + 2 apo-[cyanocobalamin reductase] + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z3C8-1", "Q5E9C8-1" ], "evidence": [ { "id": "16113", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16113" } ] }, { "id": "40719", "name": "", "equation": "apo-[alkylcobalamin reductase] + an R-cob(III)alamin + glutathione = cob(I)alamin-[alkylcobalamin reductase] + an S-substituted glutathione + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z3C8-1", "Q5E9C8-1" ], "evidence": [ { "id": "40719", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40719" } ] }, { "id": "63132", "name": "", "equation": "apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z3C8-1", "Q5E9C8-1" ], "evidence": [ { "id": "63132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63132" } ] }, { "id": "63136", "name": "", "equation": "apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z3C8-1", "Q5E9C8-1" ], "evidence": [ { "id": "63136", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63136" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z3C8", "gene_name": "MMACHC", "activity": [ { "ec_number": "1.16.1.6", "activity": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 cyanocob(III)alamin + 2 apo-[cyanocobalamin reductase] + NADPH + H(+).", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ] }, { "ec_number": "2.5.1.151", "activity": "apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+).", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ] }, { "ec_number": "1.16.1.6", "activity": "", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ] }, { "ec_number": "2.5.1.151", "activity": "", "evidence": [ { "id": "A0AAF6Z3C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3C8" } ] } ] }, { "uniprot_ac": "Q5E9C8", "gene_name": "MMACHC", "activity": [ { "ec_number": "1.16.1.6", "activity": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 cyanocob(III)alamin + 2 apo-[cyanocobalamin reductase] + NADPH + H(+).", "evidence": [ { "id": "Q5E9C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C8" } ] }, { "ec_number": "2.5.1.151", "activity": "apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+).", "evidence": [ { "id": "Q5E9C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.16.1.6", "ec_name": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 cyanocob(III)alamin + 2 apo-[cyanocobalamin reductase] + NADPH + H(+).", "evidence": [ { "id": "1.16.1.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.6" } ] }, { "ec_number": "2.5.1.151", "ec_name": "apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+).", "evidence": [ { "id": "2.5.1.151", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.151" }, { "id": "2.5.1.151", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.151" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z3Q7-1", "uniprot_ac": "A0AAF6Z3Q7", "uniprot_id": "A0AAF6Z3Q7_BOVIN", "mass": { "chemical_mass": 36086.0, "monoisotopic_mass": 36086.0 }, "refseq": {}, "gene_names": [ { "name": "METTL1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ] } ], "protein_names": [ { "name": "tRNA (guanine-N(7)-)-methyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.33", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7/entry#names_and_taxonomy" } ] }, { "name": "Methyltransferase-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7/entry#names_and_taxonomy" } ] }, { "name": "tRNA (guanine(46)-N(7))-methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7/entry#names_and_taxonomy" } ] }, { "name": "tRNA(m7G46)-methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7#function" }, { "database": "HAMAP", "id": "MF_03055", "url": "https://hamap.expasy.org/signature/MF_03055" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7", "locus": { "chromosome": "5", "start_pos": 55697174, "end_pos": 55692795, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016908", "url": "https://www.ensembl.org/id/ENSBTAG00000016908" } ] } } ], "crossref": [ { "id": "A0AAF6Z3Q7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z3Q7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23417", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23417", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23417:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23417:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "42708", "url": "https://www.rhea-db.org/rhea/42708", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDSEPHGCPVAPSPASSSLPSFLQSDFLESLDLHVGSVEKLALDIMAGTETGDAAGTEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEDMDWSELYPEFFAPLPQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFHKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHEWMCTHFEGHPLFERVPLEELSEDPIVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPALPAVTPTPTPPGH", "length": 323, "header": "tr|A0AAF6Z3Q7-1|A0AAF6Z3Q7_BOVIN Isoform 1 of tRNA (guanine-N(7)-)-methyltransferase OS=Bos taurus OX=9913 GN=METTL1 PE=3 SV=1 CANONICAL=A0AAF6Z3Q7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z3Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7/entry", "sequence": { "sequence": "MGDSEPHGCPVAPSPASSSLPSFLQSDFLESLDLHVGSVEKLALDIMAGTETGDAAGTEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEDMDWSELYPEFFAPLPQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFHKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHEWMCTHFEGHPLFERVPLEELSEDPIVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPALPAVTPTPTPPGH", "length": 323, "header": "tr|A0AAF6Z3Q7-1|A0AAF6Z3Q7_BOVIN Isoform 1 of tRNA (guanine-N(7)-)-methyltransferase OS=Bos taurus OX=9913 GN=METTL1 PE=3 SV=1 CANONICAL=A0AAF6Z3Q7-1" }, "locus": { "chromosome": "5", "start_pos": 55696722, "end_pos": 55693032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022487.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022487.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022487.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022487.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 317, "start_aa": "Thr", "end_pos": 317, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr317", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 319, "start_aa": "Thr", "end_pos": 319, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr319", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [ { "start_pos": 74, "end_pos": 74, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKB and RPS6KA3", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "site_lbl": "Ser74" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" }, { "name": "tRNA (m7G46) methyltransferase complex", "id": "GO:0106143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106143", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" }, { "name": "tRNA (guanine(46)-N7)-methyltransferase activity", "id": "GO:0008176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008176", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" }, { "name": "internal mRNA (guanine-N7-)-methyltransferase activity", "id": "GO:0160090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160090", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to stress", "id": "GO:0033554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033554", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" }, { "name": "tRNA stabilization", "id": "GO:0036416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036416", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z3Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "42708", "name": "", "equation": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z3Q7-1", "Q2YDF1-1" ], "evidence": [ { "id": "42708", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42708" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z3Q7", "gene_name": "METTL1", "activity": [ { "ec_number": "2.1.1.33", "activity": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ] }, { "ec_number": "2.1.1.33", "activity": "", "evidence": [ { "id": "A0AAF6Z3Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3Q7" } ] } ] }, { "uniprot_ac": "Q2YDF1", "gene_name": "METTL1", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q2YDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF1" } ] }, { "ec_number": "2.1.1.33", "activity": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q2YDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF1" } ] }, { "ec_number": "2.1.1.33", "activity": "", "evidence": [ { "id": "Q2YDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF1" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.33", "ec_name": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "2.1.1.33", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.33" }, { "id": "2.1.1.33", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.33" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 317, 319 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 74 ], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z482-1", "uniprot_ac": "A0AAF6Z482", "uniprot_id": "A0AAF6Z482_BOVIN", "mass": { "chemical_mass": 81971.0, "monoisotopic_mass": 81971.0 }, "refseq": { "ac": "XP_059731444", "name": "eEF1A lysine and N-terminal methyltransferase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731444" }, "gene_names": [ { "name": "METTL13", "type": "recommended", "evidence": [ { "id": "A0AAF6Z482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ] }, { "name": "EEF1AKNMT", "type": "synonym", "evidence": [ { "id": "XP_059731444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731444" } ] }, { "name": "METTL13", "type": "synonym", "evidence": [ { "id": "XP_059731444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731444" } ] } ], "protein_names": [ { "name": "eEF1A lysine and N-terminal methyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482/entry#names_and_taxonomy" } ] }, { "name": "Methyltransferase-like protein 13", "type": "synonym", "evidence": [ { "id": "A0AAF6Z482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482/entry#names_and_taxonomy" } ] }, { "name": "eEF1A lysine and N-terminal methyltransferase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731444" } ] } ], "function": [ { "annotation": "Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482#function" }, { "database": "UniProtKB", "id": "ARBA00057391", "url": "https://www.uniprot.org/uniprotkb/ARBA00057391#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL13", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482", "locus": { "chromosome": "16", "start_pos": 39202798, "end_pos": 39186170, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017721", "url": "https://www.ensembl.org/id/ENSBTAG00000017721" } ] } } ], "crossref": [ { "id": "A0AAF6Z482", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z482", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538472", "url": "https://www.ncbi.nlm.nih.gov/gene/538472", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041698", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12176:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12176:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13649", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13649", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731444", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z482-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLLPKSSKEFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVVGCGNSELSEQLYDVGYQDIVNIDISEVVIKQMKERNASRRPRMSFLKMDMTQMEFPDASFQVVLDKGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHVLKKAVGHFSREGWMVRVHQVASSQDQLLEAEPRFSLPVFAFIMTKFRPVTGSALQIFELCAQEQGKPVRLESAEQLAEAVRERQQYAWLCSQLYRKAGLGSVSLDLCNGDTGEPRYTLHVVDSPTVKPSRDNHFAIFIIPQGRETEWLFGMEEGRKQLAASAGFRRLITVALHRGQQYEGMDSIQAELSARVMELAPAGMPAQLQVPFLSVGGDIGVRIVQHQACSPLSGDYVIEDVQGDDKRYFRRLIFLSNRNVVQSEARLLQDVSHRAQKKRKKDRKKHRPADTPEDLPAAQGQSIDKSYLCCEHHKAMIAGLALLKNPELLLETPLALLVVGLGGGSLPLFIHDHFPKSCIHAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDFITRLAEEEARPHYDVIMFDVDSKDPTLGMSCPPPAFVAQLFLQKVKSILTPEGMKNRRWRGRRDGPFRKIFFLMKNARVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHSECKLATPELLEMARALEQTLRKPGKGWDDTYVLSDMLNTVKIV", "length": 724, "header": "tr|A0AAF6Z482-1|A0AAF6Z482_BOVIN Isoform 1 of eEF1A lysine and N-terminal methyltransferase OS=Bos taurus OX=9913 GN=METTL13 PE=3 SV=1 CANONICAL=A0AAF6Z482-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z482-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482/entry", "sequence": { "sequence": "MNLLPKSSKEFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVVGCGNSELSEQLYDVGYQDIVNIDISEVVIKQMKERNASRRPRMSFLKMDMTQMEFPDASFQVVLDKGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHVLKKAVGHFSREGWMVRVHQVASSQDQLLEAEPRFSLPVFAFIMTKFRPVTGSALQIFELCAQEQGKPVRLESAEQLAEAVRERQQYAWLCSQLYRKAGLGSVSLDLCNGDTGEPRYTLHVVDSPTVKPSRDNHFAIFIIPQGRETEWLFGMEEGRKQLAASAGFRRLITVALHRGQQYEGMDSIQAELSARVMELAPAGMPAQLQVPFLSVGGDIGVRIVQHQACSPLSGDYVIEDVQGDDKRYFRRLIFLSNRNVVQSEARLLQDVSHRAQKKRKKDRKKHRPADTPEDLPAAQGQSIDKSYLCCEHHKAMIAGLALLKNPELLLETPLALLVVGLGGGSLPLFIHDHFPKSCIHAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDFITRLAEEEARPHYDVIMFDVDSKDPTLGMSCPPPAFVAQLFLQKVKSILTPEGMKNRRWRGRRDGPFRKIFFLMKNARVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHSECKLATPELLEMARALEQTLRKPGKGWDDTYVLSDMLNTVKIV", "length": 724, "header": "tr|A0AAF6Z482-1|A0AAF6Z482_BOVIN Isoform 1 of eEF1A lysine and N-terminal methyltransferase OS=Bos taurus OX=9913 GN=METTL13 PE=3 SV=1 CANONICAL=A0AAF6Z482-1" }, "locus": { "chromosome": "16", "start_pos": 39202246, "end_pos": 39186455, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023571.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023571.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023571.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023571.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-lysine N-methyltransferase activity", "id": "GO:0016279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016279", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z482", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z482" }, { "id": "PF13649", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13649" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methyltransferase", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 147, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z494-1", "uniprot_ac": "A0AAF6Z494", "uniprot_id": "A0AAF6Z494_BOVIN", "mass": { "chemical_mass": 39971.0, "monoisotopic_mass": 39971.0 }, "refseq": {}, "gene_names": [ { "name": "SBSPON", "type": "recommended", "evidence": [ { "id": "A0AAF6Z494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494" } ] } ], "protein_names": [ { "name": "Somatomedin B and thrombospondin type 1 domain containing", "type": "synonym", "evidence": [ { "id": "A0AAF6Z494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z494", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SBSPON", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494", "locus": { "chromosome": "14", "start_pos": 36436043, "end_pos": 36467496, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017249", "url": "https://www.ensembl.org/id/ENSBTAG00000017249" } ] } } ], "crossref": [ { "id": "A0AAF6Z494", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z494", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20920:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20920:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF19028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z494", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z494-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWPPWRGGWRARSLPEIPEHLLFRCLPAFPAGRAMGAVGRGPGSRASIAGAGGGGALPAGPRPAPDGRAARAGVGRGPARGRAGPGCSGAGALRGTPALAPKVCRARAMRTLWMALCVLARLWPGALAGCADAGRCCPGRDPACFASGWRQDRVYGTCFCDQACRLTGDCCFDYARACPARPCIVGEWSPWSGCASQCRPTARVRRRAVQQEPQNGGEPCPALEERAGCLEYATPQGEDCGHAFVPAFITTSAFNKERTRQAASPHWTTSTEDAGYCMEFKTESLTHHCALENRPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVEQCSCPAVHSFIFI", "length": 372, "header": "tr|A0AAF6Z494-1|A0AAF6Z494_BOVIN Isoform 1 of Somatomedin B and thrombospondin type 1 domain containing OS=Bos taurus OX=9913 GN=SBSPON PE=4 SV=1 CANONICAL=A0AAF6Z494-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z494-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494/entry", "sequence": { "sequence": "MWPPWRGGWRARSLPEIPEHLLFRCLPAFPAGRAMGAVGRGPGSRASIAGAGGGGALPAGPRPAPDGRAARAGVGRGPARGRAGPGCSGAGALRGTPALAPKVCRARAMRTLWMALCVLARLWPGALAGCADAGRCCPGRDPACFASGWRQDRVYGTCFCDQACRLTGDCCFDYARACPARPCIVGEWSPWSGCASQCRPTARVRRRAVQQEPQNGGEPCPALEERAGCLEYATPQGEDCGHAFVPAFITTSAFNKERTRQAASPHWTTSTEDAGYCMEFKTESLTHHCALENRPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVEQCSCPAVHSFIFI", "length": 372, "header": "tr|A0AAF6Z494-1|A0AAF6Z494_BOVIN Isoform 1 of Somatomedin B and thrombospondin type 1 domain containing OS=Bos taurus OX=9913 GN=SBSPON PE=4 SV=1 CANONICAL=A0AAF6Z494-1" }, "locus": { "chromosome": "14", "start_pos": 36467380, "end_pos": 36436380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022924.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022924.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022924.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022924.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z494" }, { "id": "PS50958", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50958" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SMB", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 183, "start_aa": "Asp", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 335, "end_pos": 337 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4F0-1", "uniprot_ac": "A0AAF6Z4F0", "uniprot_id": "A0AAF6Z4F0_BOVIN", "mass": { "chemical_mass": 18361.0, "monoisotopic_mass": 18361.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM256", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0" } ] } ], "protein_names": [ { "name": "Transmembrane protein 256", "type": "synonym", "evidence": [ { "id": "A0AAF6Z4F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM256", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0", "locus": { "chromosome": "19", "start_pos": 27081979, "end_pos": 27083231, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031752", "url": "https://www.ensembl.org/id/ENSBTAG00000031752" } ] } } ], "crossref": [ { "id": "A0AAF6Z4F0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4F0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43461:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43461:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z4F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPGAAFRRLGALSGAGALGLASYGAHGQGAGDGTGIVLGEIFRIWCRGRVQRKCRPSHRPDCPRNPEPFKKPISRVHWVPRTVRAQFPDAYGKELFDKTNKHHFLHSLALLAVPLCRKPLWAGLLLASGTTLFCTTFYYQALSGDPSFQNLAPVGGSLLLLGWLALAL", "length": 170, "header": "tr|A0AAF6Z4F0-1|A0AAF6Z4F0_BOVIN Isoform 1 of Transmembrane protein 256 OS=Bos taurus OX=9913 GN=TMEM256 PE=3 SV=1 CANONICAL=A0AAF6Z4F0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0/entry", "sequence": { "sequence": "MAGPGAAFRRLGALSGAGALGLASYGAHGQGAGDGTGIVLGEIFRIWCRGRVQRKCRPSHRPDCPRNPEPFKKPISRVHWVPRTVRAQFPDAYGKELFDKTNKHHFLHSLALLAVPLCRKPLWAGLLLASGTTLFCTTFYYQALSGDPSFQNLAPVGGSLLLLGWLALAL", "length": 170, "header": "tr|A0AAF6Z4F0-1|A0AAF6Z4F0_BOVIN Isoform 1 of Transmembrane protein 256 OS=Bos taurus OX=9913 GN=TMEM256 PE=3 SV=1 CANONICAL=A0AAF6Z4F0-1" }, "locus": { "chromosome": "19", "start_pos": 27083097, "end_pos": 27082095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023810.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023810.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023810.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023810.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4F0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4F8-1", "uniprot_ac": "A0AAF6Z4F8", "uniprot_id": "A0AAF6Z4F8_BOVIN", "mass": { "chemical_mass": 53503.0, "monoisotopic_mass": 53503.0 }, "refseq": { "ac": "XP_005206345", "name": "peripherin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206345" }, "gene_names": [ { "name": "PRPH", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8" } ] }, { "name": "PRPH", "type": "synonym", "evidence": [ { "id": "XP_005206345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206345" } ] } ], "protein_names": [ { "name": "Peripherin", "type": "synonym", "evidence": [ { "id": "A0AAF6Z4F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8/entry#names_and_taxonomy" } ] }, { "name": "peripherin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005206345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206345" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRPH", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8", "locus": { "chromosome": "5", "start_pos": 30519074, "end_pos": 30522802, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017864", "url": "https://www.ensembl.org/id/ENSBTAG00000017864" } ] } } ], "crossref": [ { "id": "A0AAF6Z4F8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4F8", "database": "AlphaFoldDB", "categories": [] }, { "id": "510082", "url": "https://www.ncbi.nlm.nih.gov/gene/510082", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45652:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45652:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005206345", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206345", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHPSGLRSSVSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPGSSVRLGSFRGPRAGTGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELNQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQLSVESQQVQHVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSIKTTVPEVEPPQETHSRKMVLIRTIETRDGEVVTESQKEQHSELDKSPQSY", "length": 468, "header": "tr|A0AAF6Z4F8-1|A0AAF6Z4F8_BOVIN Isoform 1 of Peripherin OS=Bos taurus OX=9913 GN=PRPH PE=3 SV=1 CANONICAL=A0AAF6Z4F8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8/entry", "sequence": { "sequence": "MSHPSGLRSSVSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPGSSVRLGSFRGPRAGTGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELNQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQLSVESQQVQHVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSIKTTVPEVEPPQETHSRKMVLIRTIETRDGEVVTESQKEQHSELDKSPQSY", "length": 468, "header": "tr|A0AAF6Z4F8-1|A0AAF6Z4F8_BOVIN Isoform 1 of Peripherin OS=Bos taurus OX=9913 GN=PRPH PE=3 SV=1 CANONICAL=A0AAF6Z4F8-1" }, "locus": { "chromosome": "5", "start_pos": 30522754, "end_pos": 30519605, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023744.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023744.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023744.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023744.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z4F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4F8" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 406, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 312, "end_pos": 314 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4R1-1", "uniprot_ac": "A0AAF6Z4R1", "uniprot_id": "A0AAF6Z4R1_BOVIN", "mass": { "chemical_mass": 25062.0, "monoisotopic_mass": 25062.0 }, "refseq": {}, "gene_names": [ { "name": "SCNM1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1" } ] } ], "protein_names": [ { "name": "Sodium channel modifier 1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCNM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1", "locus": { "chromosome": "3", "start_pos": 19641911, "end_pos": 19644982, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018070", "url": "https://www.ensembl.org/id/ENSBTAG00000018070" } ] } } ], "crossref": [ { "id": "A0AAF6Z4R1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4R1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR031622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR32297", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32297", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32297:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32297:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15803", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15803", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z4R1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKPPGKGTEQNPRQHNELRREETTAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPRPSVSRPPLPPPEVEPQGGKISREPEPEAGSQTKESATVSSPAPMSPTRRRALDHYLTLRSSVFWCFQLWMDPRWTRSMDKR", "length": 219, "header": "tr|A0AAF6Z4R1-1|A0AAF6Z4R1_BOVIN Isoform 1 of Sodium channel modifier 1 OS=Bos taurus OX=9913 GN=SCNM1 PE=4 SV=1 CANONICAL=A0AAF6Z4R1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1/entry", "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKPPGKGTEQNPRQHNELRREETTAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPRPSVSRPPLPPPEVEPQGGKISREPEPEAGSQTKESATVSSPAPMSPTRRRALDHYLTLRSSVFWCFQLWMDPRWTRSMDKR", "length": 219, "header": "tr|A0AAF6Z4R1-1|A0AAF6Z4R1_BOVIN Isoform 1 of Sodium channel modifier 1 OS=Bos taurus OX=9913 GN=SCNM1 PE=4 SV=1 CANONICAL=A0AAF6Z4R1-1" }, "locus": { "chromosome": "3", "start_pos": 19644919, "end_pos": 19642558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024057.4", "url": "https://www.ensembl.org/id/ENSBTAT00000024057.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024057.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024057.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "alternative mRNA splicing, via spliceosome", "id": "GO:0000380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4R1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R1" }, { "id": "PF15803", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15803" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sodium channel modifier 1 zinc-finger", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 69, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4S4-1", "uniprot_ac": "A0AAF6Z4S4", "uniprot_id": "A0AAF6Z4S4_BOVIN", "mass": { "chemical_mass": 21504.0, "monoisotopic_mass": 21504.0 }, "refseq": {}, "gene_names": [ { "name": "PEBP1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4" } ] } ], "protein_names": [ { "name": "Phosphatidylethanolamine-binding protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4/entry#names_and_taxonomy" } ] }, { "name": "HCNPpp", "type": "synonym", "evidence": [ { "id": "A0AAF6Z4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4#function" }, { "database": "UniProtKB", "id": "ARBA00037110", "url": "https://www.uniprot.org/uniprotkb/ARBA00037110#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PEBP1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4", "locus": { "chromosome": "17", "start_pos": 57079439, "end_pos": 57084736, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018115", "url": "https://www.ensembl.org/id/ENSBTAG00000018115" } ] } } ], "crossref": [ { "id": "A0AAF6Z4S4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4S4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00866", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00866", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11362", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11362", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11362:SF151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11362:SF151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVDLSKWSGPLSLQEVDERPQHPLQVKYGGAEVDELGKVLTPTQVKNRPTSITWDGLDPGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNNISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQEGPLKCDEPILSNRSGDHRGKFKVASFRKKYLLACVFTALSHQDNQGTPNVSGWLLRVSVPLWLL", "length": 192, "header": "tr|A0AAF6Z4S4-1|A0AAF6Z4S4_BOVIN Isoform 1 of Phosphatidylethanolamine-binding protein 1 OS=Bos taurus OX=9913 GN=PEBP1 PE=3 SV=1 CANONICAL=A0AAF6Z4S4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4/entry", "sequence": { "sequence": "MPVDLSKWSGPLSLQEVDERPQHPLQVKYGGAEVDELGKVLTPTQVKNRPTSITWDGLDPGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNNISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQEGPLKCDEPILSNRSGDHRGKFKVASFRKKYLLACVFTALSHQDNQGTPNVSGWLLRVSVPLWLL", "length": 192, "header": "tr|A0AAF6Z4S4-1|A0AAF6Z4S4_BOVIN Isoform 1 of Phosphatidylethanolamine-binding protein 1 OS=Bos taurus OX=9913 GN=PEBP1 PE=3 SV=1 CANONICAL=A0AAF6Z4S4-1" }, "locus": { "chromosome": "17", "start_pos": 57084640, "end_pos": 57080443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024107.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024107.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024107.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024107.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4S4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z556-1", "uniprot_ac": "A0AAF6Z556", "uniprot_id": "A0AAF6Z556_BOVIN", "mass": { "chemical_mass": 20221.0, "monoisotopic_mass": 20221.0 }, "refseq": {}, "gene_names": [ { "name": "PSENEN", "type": "recommended", "evidence": [ { "id": "A0AAF6Z556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556" } ] } ], "protein_names": [ { "name": "Gamma-secretase subunit PEN-2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z556", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSENEN", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556", "locus": { "chromosome": "18", "start_pos": 46460717, "end_pos": 46458839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018593", "url": "https://www.ensembl.org/id/ENSBTAG00000018593" } ] } } ], "crossref": [ { "id": "A0AAF6Z556", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z556", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16318:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16318:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10251", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10251", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z556", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z556-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPSHQAHPVELPEDACARRCLTKKTTISRETWGISRKSPWLKVAKGPRPEEVKTPLGQDLGLAPDPRKTGPSATMNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFIVPAYTEQSQIKGYVWRSAVGFFLWVIVLSTWITIFQIYRPRWGALGDYLSFTIPLGTP", "length": 176, "header": "tr|A0AAF6Z556-1|A0AAF6Z556_BOVIN Isoform 1 of Gamma-secretase subunit PEN-2 OS=Bos taurus OX=9913 GN=PSENEN PE=3 SV=1 CANONICAL=A0AAF6Z556-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z556-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556/entry", "sequence": { "sequence": "MPPSHQAHPVELPEDACARRCLTKKTTISRETWGISRKSPWLKVAKGPRPEEVKTPLGQDLGLAPDPRKTGPSATMNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFIVPAYTEQSQIKGYVWRSAVGFFLWVIVLSTWITIFQIYRPRWGALGDYLSFTIPLGTP", "length": 176, "header": "tr|A0AAF6Z556-1|A0AAF6Z556_BOVIN Isoform 1 of Gamma-secretase subunit PEN-2 OS=Bos taurus OX=9913 GN=PSENEN PE=3 SV=1 CANONICAL=A0AAF6Z556-1" }, "locus": { "chromosome": "18", "start_pos": 46460583, "end_pos": 46459038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024745.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024745.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024745.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024745.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z556", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z556", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z556" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z575-1", "uniprot_ac": "A0AAF6Z575", "uniprot_id": "A0AAF6Z575_BOVIN", "mass": { "chemical_mass": 47304.0, "monoisotopic_mass": 47304.0 }, "refseq": { "ac": "XP_005203052", "name": "S100P-binding protein isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203052" }, "gene_names": [ { "name": "S100PBP", "type": "recommended", "evidence": [ { "id": "A0AAF6Z575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575" } ] }, { "name": "S100PBP", "type": "synonym", "evidence": [ { "id": "XP_005203052", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203052" } ] } ], "protein_names": [ { "name": "S100P-binding protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575/entry#names_and_taxonomy" } ] }, { "name": "S100P-binding protein isoform X4", "type": "synonym", "evidence": [ { "id": "XP_005203052", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203052" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z575", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100PBP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575", "locus": { "chromosome": "2", "start_pos": 120817208, "end_pos": 120848832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018067", "url": "https://www.ensembl.org/id/ENSBTAG00000018067" } ] } } ], "crossref": [ { "id": "A0AAF6Z575", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z575", "database": "AlphaFoldDB", "categories": [] }, { "id": "539983", "url": "https://www.ncbi.nlm.nih.gov/gene/539983", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14455", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14455", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14455:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14455:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15427", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15427", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203052", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203052", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z575", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z575-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMCSLVPSEQSSGTSLLPKDNAPFSWSSLDEDELDDSLLELSDGEDDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDDSRNVEKGEKGSQIPLDTPQEKDSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVTVAPFDPTVCDVALDKDKTYVSEVTSRVTEKPSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPSSNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPNTGSSRRNGSYKSSFEMKLPVSSSSSKQDVLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQVHHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRLPDFPYGPFVSSHQQ", "length": 423, "header": "tr|A0AAF6Z575-1|A0AAF6Z575_BOVIN Isoform 1 of S100P-binding protein OS=Bos taurus OX=9913 GN=S100PBP PE=4 SV=1 CANONICAL=A0AAF6Z575-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z575-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575/entry", "sequence": { "sequence": "MMCSLVPSEQSSGTSLLPKDNAPFSWSSLDEDELDDSLLELSDGEDDGHFSFTEEQIQELLKDDDLSNEHFPWGGGLPSDDSRNVEKGEKGSQIPLDTPQEKDSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVTVAPFDPTVCDVALDKDKTYVSEVTSRVTEKPSSLGEEMREDDLSPNESTLCTESEGISPDNSASDGPPLPSSNSNFQHTVSDKNMSDSKKATPVFSQILDHSETPNTGSSRRNGSYKSSFEMKLPVSSSSSKQDVLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFSPSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQVHHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWVDRNKRSHHRFQRLPDFPYGPFVSSHQQ", "length": 423, "header": "tr|A0AAF6Z575-1|A0AAF6Z575_BOVIN Isoform 1 of S100P-binding protein OS=Bos taurus OX=9913 GN=S100PBP PE=4 SV=1 CANONICAL=A0AAF6Z575-1" }, "locus": { "chromosome": "2", "start_pos": 120842505, "end_pos": 120817769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024053.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024053.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024053.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024053.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 132, "start_aa": "Thr", "end_pos": 132, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr132", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z575", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z575", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z575" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 132 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 264, "end_pos": 266 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z5Y5-1", "uniprot_ac": "A0AAF6Z5Y5", "uniprot_id": "A0AAF6Z5Y5_BOVIN", "mass": { "chemical_mass": 44243.0, "monoisotopic_mass": 44243.0 }, "refseq": { "ac": "XP_005217192", "name": "filamin-binding LIM protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217192" }, "gene_names": [ { "name": "FBLIM1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ] }, { "name": "FBLIM1", "type": "synonym", "evidence": [ { "id": "XP_005217192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217192" } ] } ], "protein_names": [ { "name": "Filamin-binding LIM protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z5Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5/entry#names_and_taxonomy" } ] }, { "name": "filamin-binding LIM protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217192" } ] } ], "function": [ { "annotation": "Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ADZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADZ3#function" }, { "database": "UniProtKB", "id": "ARBA00054134", "url": "https://www.uniprot.org/uniprotkb/ARBA00054134#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBLIM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5", "locus": { "chromosome": "16", "start_pos": 51777677, "end_pos": 51802788, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018725", "url": "https://www.ensembl.org/id/ENSBTAG00000018725" } ] } } ], "crossref": [ { "id": "A0AAF6Z5Y5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z5Y5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09372", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09372", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767833", "url": "https://www.ncbi.nlm.nih.gov/gene/767833", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24207:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24207:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217192", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217192", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ADZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ADZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGAGLNTGDLSLPRKIQIPAPPEAETMASKPEKRVASSVFITLVPPRRDEAVVEEVRRAACEAWPGRPWESAPTKAPGAGSVGKLRSWMPPGRAAAPGPAVPPQLSNGGCSLPPPPLDVDDALPDLDLLPPPPPPPAADLPPPDEEPHSAMGASLISDLEQLHLPPPPPPPQALVEGPPLQPRPSHLKPAEEELPPPPEEPVSFPEREASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRVCRRQLAGQSFYQKDGRPLCEPCYQDTLEKCGKCGEVVREHIIRALGQAFHPSCFTCVTCARRIGDESFALDSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRVLLSVEPTDQGCYPLNNRLFCKPCHVKRSAAGCC", "length": 405, "header": "tr|A0AAF6Z5Y5-1|A0AAF6Z5Y5_BOVIN Isoform 1 of Filamin-binding LIM protein 1 OS=Bos taurus OX=9913 GN=FBLIM1 PE=4 SV=1 CANONICAL=A0AAF6Z5Y5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z5Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5/entry", "sequence": { "sequence": "MSGAGLNTGDLSLPRKIQIPAPPEAETMASKPEKRVASSVFITLVPPRRDEAVVEEVRRAACEAWPGRPWESAPTKAPGAGSVGKLRSWMPPGRAAAPGPAVPPQLSNGGCSLPPPPLDVDDALPDLDLLPPPPPPPAADLPPPDEEPHSAMGASLISDLEQLHLPPPPPPPQALVEGPPLQPRPSHLKPAEEELPPPPEEPVSFPEREASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRVCRRQLAGQSFYQKDGRPLCEPCYQDTLEKCGKCGEVVREHIIRALGQAFHPSCFTCVTCARRIGDESFALDSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRVLLSVEPTDQGCYPLNNRLFCKPCHVKRSAAGCC", "length": 405, "header": "tr|A0AAF6Z5Y5-1|A0AAF6Z5Y5_BOVIN Isoform 1 of Filamin-binding LIM protein 1 OS=Bos taurus OX=9913 GN=FBLIM1 PE=4 SV=1 CANONICAL=A0AAF6Z5Y5-1" }, "locus": { "chromosome": "16", "start_pos": 51802589, "end_pos": 51779032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024926.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024926.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024926.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024926.4" } ] } }, { "isoform_ac": "A0AAF7ADZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADZ3/entry", "sequence": { "sequence": "MASKPEKRVASSVFITLVPPRRDEAVVEEVRRAACEAWPGRPWESAPTKAPGAGSVGKLRSWMPPGRAAAPGPAVPPQLSNGDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRVCRRQLAGQSFYQKDGRPLCEPCYQDTLEKCGKCGEVVREHIIRALGQAFHPSCFTCVTCARRIGDESFALDSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRVLLSVEPTDQGCYPLNNRLFCKPCHVKRSAAGCC", "length": 275, "header": "tr|A0AAF7ADZ3-1|A0AAF7ADZ3_BOVIN Computationally mapped isoform of Filamin-binding LIM protein 1 OS=Bos taurus OX=9913 GN=FBLIM1 PE=4 SV=1 CANONICAL=A0AAF6Z5Y5-1" }, "locus": { "chromosome": "16", "start_pos": 51798875, "end_pos": 51779032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076589.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076589.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067709.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067709.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of integrin activation", "id": "GO:0033623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033623", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" }, { "name": "filamin binding", "id": "GO:0031005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z5Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z5Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Y5" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 213, "end_pos": 274, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z6F6-1", "uniprot_ac": "A0AAF6Z6F6", "uniprot_id": "A0AAF6Z6F6_BOVIN", "mass": { "chemical_mass": 19662.0, "monoisotopic_mass": 19662.0 }, "refseq": {}, "gene_names": [ { "name": "OOEP", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" } ] } ], "protein_names": [ { "name": "Oocyte expressed protein", "type": "synonym", "evidence": [ { "id": "A0AAF6Z6F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6F6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OOEP", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6", "locus": { "chromosome": "9", "start_pos": 12764531, "end_pos": 12766525, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019600", "url": "https://www.ensembl.org/id/ENSBTAG00000019600" } ] } } ], "crossref": [ { "id": "A0AAF6Z6F6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z6F6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12795", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12795", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR031952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19447", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19447", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19447:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19447:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z6F6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVDNAGDYEARGDRLLGFPLPSPRVRIRPWWFPAQELRNPLVFFLEAWLADLIFGPDRALVPEMEWMSQALLMVDAVDAGNLVEVTVFARPAVQRQVKSVLLSQASVHREQRARDPRFRASSPRNDTASTPLPPWRRSLKPSIFPYPAEKMEQLEEFLKAQAPGPQVPQHPVA", "length": 173, "header": "tr|A0AAF6Z6F6-1|A0AAF6Z6F6_BOVIN Isoform 1 of Oocyte expressed protein OS=Bos taurus OX=9913 GN=OOEP PE=3 SV=1 CANONICAL=A0AAF6Z6F6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z6F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6/entry", "sequence": { "sequence": "MVDNAGDYEARGDRLLGFPLPSPRVRIRPWWFPAQELRNPLVFFLEAWLADLIFGPDRALVPEMEWMSQALLMVDAVDAGNLVEVTVFARPAVQRQVKSVLLSQASVHREQRARDPRFRASSPRNDTASTPLPPWRRSLKPSIFPYPAEKMEQLEEFLKAQAPGPQVPQHPVA", "length": 173, "header": "tr|A0AAF6Z6F6-1|A0AAF6Z6F6_BOVIN Isoform 1 of Oocyte expressed protein OS=Bos taurus OX=9913 GN=OOEP PE=3 SV=1 CANONICAL=A0AAF6Z6F6-1" }, "locus": { "chromosome": "9", "start_pos": 12766440, "end_pos": 12765535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026114.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026114.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026114.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026114.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6F6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6F6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6F6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" } ], "pmid": "" }, { "name": "subcortical maternal complex", "id": "GO:0106333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106333", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6F6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z6F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6F6" }, { "id": "PF16005", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16005" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KH-like RNA-binding", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 112, "start_aa": "Ile", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z6G5-1", "uniprot_ac": "A0AAF6Z6G5", "uniprot_id": "A0AAF6Z6G5_BOVIN", "mass": { "chemical_mass": 71387.0, "monoisotopic_mass": 71387.0 }, "refseq": {}, "gene_names": [ { "name": "KIAA2013", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5" } ] } ], "protein_names": [ { "name": "KIAA2013 ortholog", "type": "synonym", "evidence": [ { "id": "A0AAF6Z6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6G5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA2013", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5", "locus": { "chromosome": "16", "start_pos": 41759432, "end_pos": 41753812, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019388", "url": "https://www.ensembl.org/id/ENSBTAG00000019388" } ] } } ], "crossref": [ { "id": "A0AAF6Z6G5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z6G5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31386", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31386", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31386:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31386:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z6G5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLVLLLWFAGSGARRAAGGLQLLPWPHGEPGAAEPSACLEAATHAWRSLRERGEAVLLGPGVPSLVANGFLALDVVANRLWVTPGEREPAVAPDFVPFVQLRPLSALPEAGESVLLLREGLLRRVRCLQLGTSGPGPAAAGPGPASASGLLTGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPRAFTSTLEKVGDHQFLLYSGRSPPVPTGLVHLVVVAAKKLVDRLQVAPRTQLDETVLWVVHVSGPLNPQVLKSKAAKELKVLQDLARKEMLELLEMPAAELLQDHQRLWAQLFSPASQLCWSSLTCNLCGMTGVEMKKITDAHTPSGLTVNLTLYYMLSCSPAPLLSPDLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLWDLWRLTLQKRGCKGLVRAGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQLVKIYACEAGCLDEPVELTSAPQGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPFFRNKEDPSV", "length": 651, "header": "tr|A0AAF6Z6G5-1|A0AAF6Z6G5_BOVIN Isoform 1 of KIAA2013 ortholog OS=Bos taurus OX=9913 GN=KIAA2013 PE=4 SV=1 CANONICAL=A0AAF6Z6G5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z6G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5/entry", "sequence": { "sequence": "MWLQQRLKGLPGLLSSSWARRLLCLLGLLVLLLWFAGSGARRAAGGLQLLPWPHGEPGAAEPSACLEAATHAWRSLRERGEAVLLGPGVPSLVANGFLALDVVANRLWVTPGEREPAVAPDFVPFVQLRPLSALPEAGESVLLLREGLLRRVRCLQLGTSGPGPAAAGPGPASASGLLTGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPRAFTSTLEKVGDHQFLLYSGRSPPVPTGLVHLVVVAAKKLVDRLQVAPRTQLDETVLWVVHVSGPLNPQVLKSKAAKELKVLQDLARKEMLELLEMPAAELLQDHQRLWAQLFSPASQLCWSSLTCNLCGMTGVEMKKITDAHTPSGLTVNLTLYYMLSCSPAPLLSPDLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLWDLWRLTLQKRGCKGLVRAGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQLVKIYACEAGCLDEPVELTSAPQGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPFFRNKEDPSV", "length": 651, "header": "tr|A0AAF6Z6G5-1|A0AAF6Z6G5_BOVIN Isoform 1 of KIAA2013 ortholog OS=Bos taurus OX=9913 GN=KIAA2013 PE=4 SV=1 CANONICAL=A0AAF6Z6G5-1" }, "locus": { "chromosome": "16", "start_pos": 41759199, "end_pos": 41753989, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025834.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025834.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025834.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025834.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 110, "start_aa": "Thr", "end_pos": 110, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr110", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 224, "start_aa": "Thr", "end_pos": 224, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr224", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6G5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6G5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 110, 224 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 380, "end_pos": 382 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z6Q1-1", "uniprot_ac": "A0AAF6Z6Q1", "uniprot_id": "A0AAF6Z6Q1_BOVIN", "mass": { "chemical_mass": 97333.0, "monoisotopic_mass": 97333.0 }, "refseq": {}, "gene_names": [ { "name": "TBC1D2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 2A", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1", "locus": { "chromosome": "8", "start_pos": 63314767, "end_pos": 63357767, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019550", "url": "https://www.ensembl.org/id/ENSBTAG00000019550" } ] } } ], "crossref": [ { "id": "A0AAF6Z6Q1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z6Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGAQESPAESGSSVPWSEEPAGSAKVPEVSLSEESEGCTRPLEATPPKLCGYLSKFGGKGPIRGWKSRWFFFDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGTFEIKTPNRIITLKAATKQAMLYWLQQLQMKRWEFHNSLPALPAAHDAALAGNGPALRLELEQEEEEEEAFLCPVKTPTDLVGVAAAWQPVHARPLALQNISLKHLGTEIQNTMCNIRGNKQTQGANHRPPGEDSPLIEETQREEQPSPPGPGAPGKDPANSLKSSLTTSLIRKAKSQSNTFPLFSEGLMRNRTAQEKVLALEQQVLMLTKELKAQKELVKILHKALEAAQQEKRVSSAYLAAAQDKDRLELVRHKVRQIAELGRRVEALERERESLAQTASLQEQEIRELQQHVQLLLDKNQAKQQVICKLSEKVTQDFMKAPEEADRDFLSQQEKMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLMKCAYLQAQNCQVESKYLAGLRRLQEALGVEAGECSELLRQLIQEALQWEASEASADSVVLSPSTISEYDEYGFLTVPNYEVEDLRLLAKIQALEVHSHHLLAHEAVERPLRERWATLGELAPSAELKQLLRAGVPHEHRPRVWRWLIRLRVQHLQAPGCYQALLSRGQACKHSAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLDEEESAFWCLVAIVETIMPADYYSKTLLASQVDQRVLQDLLLEKLPRLMAHLGQRHVDLSFITFNWFLVVFADSLISNILLQVWDAFLYEGIKVVFRYALAIFKYNEEALLRLQDSLEIYQYLHFFTKTICDSR", "length": 857, "header": "tr|A0AAF6Z6Q1-1|A0AAF6Z6Q1_BOVIN Isoform 1 of TBC1 domain family member 2A OS=Bos taurus OX=9913 GN=TBC1D2 PE=4 SV=1 CANONICAL=A0AAF6Z6Q1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z6Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1/entry", "sequence": { "sequence": "MEGAQESPAESGSSVPWSEEPAGSAKVPEVSLSEESEGCTRPLEATPPKLCGYLSKFGGKGPIRGWKSRWFFFDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGTFEIKTPNRIITLKAATKQAMLYWLQQLQMKRWEFHNSLPALPAAHDAALAGNGPALRLELEQEEEEEEAFLCPVKTPTDLVGVAAAWQPVHARPLALQNISLKHLGTEIQNTMCNIRGNKQTQGANHRPPGEDSPLIEETQREEQPSPPGPGAPGKDPANSLKSSLTTSLIRKAKSQSNTFPLFSEGLMRNRTAQEKVLALEQQVLMLTKELKAQKELVKILHKALEAAQQEKRVSSAYLAAAQDKDRLELVRHKVRQIAELGRRVEALERERESLAQTASLQEQEIRELQQHVQLLLDKNQAKQQVICKLSEKVTQDFMKAPEEADRDFLSQQEKMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLMKCAYLQAQNCQVESKYLAGLRRLQEALGVEAGECSELLRQLIQEALQWEASEASADSVVLSPSTISEYDEYGFLTVPNYEVEDLRLLAKIQALEVHSHHLLAHEAVERPLRERWATLGELAPSAELKQLLRAGVPHEHRPRVWRWLIRLRVQHLQAPGCYQALLSRGQACKHSAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLDEEESAFWCLVAIVETIMPADYYSKTLLASQVDQRVLQDLLLEKLPRLMAHLGQRHVDLSFITFNWFLVVFADSLISNILLQVWDAFLYEGIKVVFRYALAIFKYNEEALLRLQDSLEIYQYLHFFTKTICDSR", "length": 857, "header": "tr|A0AAF6Z6Q1-1|A0AAF6Z6Q1_BOVIN Isoform 1 of TBC1 domain family member 2A OS=Bos taurus OX=9913 GN=TBC1D2 PE=4 SV=1 CANONICAL=A0AAF6Z6Q1-1" }, "locus": { "chromosome": "8", "start_pos": 63357744, "end_pos": 63315771, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026052.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026052.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026052.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026052.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 46, "start_aa": "Thr", "end_pos": 46, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr46", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ], "pmid": "" }, { "name": "anchoring junction", "id": "GO:0070161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070161", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 672, "end_pos": 674, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 144, "start_aa": "Pro", "end_aa": "Trp", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q1" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 622, "end_pos": 814, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 46 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 211, "end_pos": 213 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 672, "end_pos": 674 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A5Q1-1", "uniprot_ac": "A0AAF7A5Q1", "uniprot_id": "A0AAF7A5Q1_BOVIN", "mass": { "chemical_mass": 99777.0, "monoisotopic_mass": 99777.0 }, "refseq": {}, "gene_names": [ { "name": "RHBDF1", "type": "recommended", "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ] } ], "protein_names": [ { "name": "Inactive rhomboid protein", "type": "recommended", "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1/entry#names_and_taxonomy" } ] }, { "name": "Rhomboid family member", "type": "synonym", "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1/entry#names_and_taxonomy" } ] }, { "name": "Rhomboid veinlet-like protein", "type": "synonym", "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1/entry#names_and_taxonomy" } ] }, { "name": "iRhom", "type": "synonym", "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q4#function" }, { "database": "UniProtKB", "id": "ARBA00002661", "url": "https://www.uniprot.org/uniprotkb/ARBA00002661#function" }, { "database": "UniProtKB", "id": "RU369051", "url": "https://www.uniprot.org/uniprotkb/RU369051#function" }, { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHBDF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1", "locus": { "chromosome": "25", "start_pos": 121331, "end_pos": 128195, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019805", "url": "https://www.ensembl.org/id/ENSBTAG00000019805" } ] } } ], "crossref": [ { "id": "A0AAF7A5Q1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A5Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "529167", "url": "https://www.ncbi.nlm.nih.gov/gene/529167", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051512", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051512", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45965", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45965", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45965:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45965:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01694", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z6Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEARRDSSSSLQHKKPPWLKLDIPAVVPPAAEEPSFLQVGPGQRGLRVQPVQCPHWDPVAQPLRRQAFLRSVSMPAEPARVPSPHQEPRRPVLQRQMSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIVDPLARGRAFRLADDAADGPSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQRRSFTPASFLEEDTADFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWERAPEQVDLTGGALDRSELERSHLMLPLERGWRKQKEGGAAAPQPKVRLRQEVVSTAGQRRGQRIAMPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGVAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIHAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAPDLAGQKRRYGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH", "length": 879, "header": "tr|A0AAF7A5Q1-1|A0AAF7A5Q1_BOVIN Isoform 1 of Inactive rhomboid protein OS=Bos taurus OX=9913 GN=RHBDF1 PE=3 SV=1 CANONICAL=A0AAF7A5Q1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z6Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6Q4/entry", "sequence": { "sequence": "MGEARRDSSSSLQHKKPPWLKLDIPAVVPPAAEEPSFLQEPRRPVLQRQMSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIVDPLARGRAFRLADDAADGPSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQRRSFTPASFLEEDTADFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWERAPEQVDLTGGALDRSELERSHLMLPLERGWRKQKEGGAAAPQPKVRLRQEVVSTAGQRRGQRIAMPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGVAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIHAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAPDLAGQKRRYGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH", "length": 831, "header": "tr|A0AAF6Z6Q4-1|A0AAF7A5Q1_BOVIN Computationally mapped isoform of Inactive rhomboid protein OS=Bos taurus OX=9913 GN=RHBDF1 PE=3 SV=1 CANONICAL=A0AAF7A5Q1-1" }, "locus": { "chromosome": "25", "start_pos": 128173, "end_pos": 121564, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026388.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026388.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026388.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026388.5" } ] } }, { "isoform_ac": "A0AAF7A5Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1/entry", "sequence": { "sequence": "MGEARRDSSSSLQHKKPPWLKLDIPAVVPPAAEEPSFLQVGPGQRGLRVQPVQCPHWDPVAQPLRRQAFLRSVSMPAEPARVPSPHQEPRRPVLQRQMSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIVDPLARGRAFRLADDAADGPSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRAQRRSFTPASFLEEDTADFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWERAPEQVDLTGGALDRSELERSHLMLPLERGWRKQKEGGAAAPQPKVRLRQEVVSTAGQRRGQRIAMPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGVAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIHAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAPDLAGQKRRYGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGVLHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIVFQLVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH", "length": 879, "header": "tr|A0AAF7A5Q1-1|A0AAF7A5Q1_BOVIN Isoform 1 of Inactive rhomboid protein OS=Bos taurus OX=9913 GN=RHBDF1 PE=3 SV=1 CANONICAL=A0AAF7A5Q1-1" }, "locus": { "chromosome": "25", "start_pos": 128173, "end_pos": 121564, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085540.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085540.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063017.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063017.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 206, "start_aa": "Thr", "end_pos": 206, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr206", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of protein secretion", "id": "GO:0050709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050709", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" }, { "name": "regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0042058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042058", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" }, { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 607, "end_pos": 609, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" }, { "id": "PF12595", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12595" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Inactive rhomboid protein 1/2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 308, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF7A5Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5Q1" }, { "id": "PF01694", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S54 rhomboid", "eco_id": "ECO_0000259", "start_pos": 675, "end_pos": 811, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 206 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 405, "end_pos": 407 }, { "start_pos": 607, "end_pos": 609 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z6T7-1", "uniprot_ac": "A0AAF6Z6T7", "uniprot_id": "A0AAF6Z6T7_BOVIN", "mass": { "chemical_mass": 53462.0, "monoisotopic_mass": 53462.0 }, "refseq": {}, "gene_names": [ { "name": "PTOV1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" } ] } ], "protein_names": [ { "name": "Prostate tumor-overexpressed gene 1 protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z6T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7#function" }, { "database": "UniProtKB", "id": "RU369088", "url": "https://www.uniprot.org/uniprotkb/RU369088#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTOV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7", "locus": { "chromosome": "18", "start_pos": 56210293, "end_pos": 56202717, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030578", "url": "https://www.ensembl.org/id/ENSBTAG00000030578" } ] } } ], "crossref": [ { "id": "A0AAF6Z6T7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z6T7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR021394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12433", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12433", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12433:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12433:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11232", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11232", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6T7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRPRRAPHRSGAGGPLGGRGRPLRPFTARAARSRSWPASPRGPQPPRIRARSAPPMQGARVFGALGPIGPSSPGLALGGLAVGEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRALPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRVMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNAIRQVITTRKQAVGPGGVAGPVQIVNNKFLAWSGVMEWQEPRPEPHSRSKRWLPSHIYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEVRVLMLLYSSEKKIFIGLIPHDQSNFVNGIRRVIANQQQVLQRNLEQEQQQRGPLGGFWPGAGCGVPHPVLLYAPHPPPLSDASEQGPLGTVPARRDGGPRPEMSPRTAPHPVRFPNKVF", "length": 479, "header": "tr|A0AAF6Z6T7-1|A0AAF6Z6T7_BOVIN Isoform 1 of Prostate tumor-overexpressed gene 1 protein OS=Bos taurus OX=9913 GN=PTOV1 PE=3 SV=1 CANONICAL=A0AAF6Z6T7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z6T7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7/entry", "sequence": { "sequence": "MVRPRRAPHRSGAGGPLGGRGRPLRPFTARAARSRSWPASPRGPQPPRIRARSAPPMQGARVFGALGPIGPSSPGLALGGLAVGEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRALPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRVMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNAIRQVITTRKQAVGPGGVAGPVQIVNNKFLAWSGVMEWQEPRPEPHSRSKRWLPSHIYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEVRVLMLLYSSEKKIFIGLIPHDQSNFVNGIRRVIANQQQVLQRNLEQEQQQRGPLGGFWPGAGCGVPHPVLLYAPHPPPLSDASEQGPLGTVPARRDGGPRPEMSPRTAPHPVRFPNKVF", "length": 479, "header": "tr|A0AAF6Z6T7-1|A0AAF6Z6T7_BOVIN Isoform 1 of Prostate tumor-overexpressed gene 1 protein OS=Bos taurus OX=9913 GN=PTOV1 PE=3 SV=1 CANONICAL=A0AAF6Z6T7-1" }, "locus": { "chromosome": "18", "start_pos": 56210290, "end_pos": 56202871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026147.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026147.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026147.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026147.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6T7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z6T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6T7" }, { "id": "PF11232", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11232" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mediator complex subunit Med25 PTOV", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 238, "start_aa": "Asn", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z704-1", "uniprot_ac": "A0AAF6Z704", "uniprot_id": "A0AAF6Z704_BOVIN", "mass": { "chemical_mass": 29691.0, "monoisotopic_mass": 29691.0 }, "refseq": {}, "gene_names": [ { "name": "RPL10A", "type": "recommended", "evidence": [ { "id": "A0AAF6Z704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704" } ] } ], "protein_names": [ { "name": "Ribosomal protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z704", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704#function" }, { "database": "UniProtKB", "id": "ARBA00034092", "url": "https://www.uniprot.org/uniprotkb/ARBA00034092#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z704", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL10A", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704", "locus": { "chromosome": "23", "start_pos": 9428500, "end_pos": 9425859, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019494", "url": "https://www.ensembl.org/id/ENSBTAG00000019494" } ] } } ], "crossref": [ { "id": "A0AAF6Z704", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z704", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00403", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00403", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00687", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00687", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z704", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z704-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SCYPRSSAPLDALVGKETLRAEAPGVLAPASLRGISCQASACGPGVRVGAPSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 267, "header": "tr|A0AAF6Z704-1|A0AAF6Z704_BOVIN Isoform 1 of Ribosomal protein OS=Bos taurus OX=9913 GN=RPL10A PE=3 SV=1 CANONICAL=A0AAF6Z704-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z704-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704/entry", "sequence": { "sequence": "SCYPRSSAPLDALVGKETLRAEAPGVLAPASLRGISCQASACGPGVRVGAPSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY", "length": 267, "header": "tr|A0AAF6Z704-1|A0AAF6Z704_BOVIN Isoform 1 of Ribosomal protein OS=Bos taurus OX=9913 GN=RPL10A PE=3 SV=1 CANONICAL=A0AAF6Z704-1" }, "locus": { "chromosome": "23", "start_pos": 9428466, "end_pos": 9426058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025963.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025963.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025963.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025963.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z704", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z704", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z704" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z716-1", "uniprot_ac": "A0AAF6Z716", "uniprot_id": "A0AAF6Z716_BOVIN", "mass": { "chemical_mass": 44841.0, "monoisotopic_mass": 44841.0 }, "refseq": {}, "gene_names": [ { "name": "KDM8", "type": "recommended", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ] } ], "protein_names": [ { "name": "Bifunctional peptidase and arginyl-hydroxylase JMJD5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716/entry#names_and_taxonomy" } ] }, { "name": "1.14.11.73", "type": "synonym", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716/entry#names_and_taxonomy" } ] }, { "name": "JmjC domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716/entry#names_and_taxonomy" } ] }, { "name": "Jumonji C domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716/entry#names_and_taxonomy" } ] }, { "name": "L-arginine (3R)-hydroxylase KDM8", "type": "synonym", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KDM8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716", "locus": { "chromosome": "25", "start_pos": 24804236, "end_pos": 24778510, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019530", "url": "https://www.ensembl.org/id/ENSBTAG00000019530" } ] } } ], "crossref": [ { "id": "A0AAF6Z716", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z716", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR041667", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041667", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12461:SF106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461:SF106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24472", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24472", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "56744", "url": "https://www.rhea-db.org/rhea/56744", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z716-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPSTLWETLQALLPHTKEELKLELGEKVEGSVLMLLQEAAELFLGGQRRECLQTCEVLLDYSWEKLNTGPWQHVDKDWRRVYAFGCLLKAVCLCEPPGDAASVAAALKACDMGLLMGAAILGDILLKVAAVLQKYLLSGKRPAPGPSQEPPGTKKARNDHVPIPDVTTERTVPRLHCPSLQYFKKHFLVPGRPVILEGVANHWPCMKKWSLEYIQEVAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIREEPKDIGYLAQHQLFDQIPELKQDISIPDYCCLGDGEEEEITINAWFGPQGTVSPLHQDPQQNFLAQVMGRKYIRLYSPQESEALYPHDTHLLHNTSQVDVENPDLEKFPSGDWVSGWLQEVQRPFCYHEEKRLICWKTMF", "length": 395, "header": "tr|A0AAF6Z716-1|A0AAF6Z716_BOVIN Isoform 1 of Bifunctional peptidase and arginyl-hydroxylase JMJD5 OS=Bos taurus OX=9913 GN=KDM8 PE=4 SV=1 CANONICAL=A0AAF6Z716-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z716-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716/entry", "sequence": { "sequence": "MAGPSTLWETLQALLPHTKEELKLELGEKVEGSVLMLLQEAAELFLGGQRRECLQTCEVLLDYSWEKLNTGPWQHVDKDWRRVYAFGCLLKAVCLCEPPGDAASVAAALKACDMGLLMGAAILGDILLKVAAVLQKYLLSGKRPAPGPSQEPPGTKKARNDHVPIPDVTTERTVPRLHCPSLQYFKKHFLVPGRPVILEGVANHWPCMKKWSLEYIQEVAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIREEPKDIGYLAQHQLFDQIPELKQDISIPDYCCLGDGEEEEITINAWFGPQGTVSPLHQDPQQNFLAQVMGRKYIRLYSPQESEALYPHDTHLLHNTSQVDVENPDLEKFPSGDWVSGWLQEVQRPFCYHEEKRLICWKTMF", "length": 395, "header": "tr|A0AAF6Z716-1|A0AAF6Z716_BOVIN Isoform 1 of Bifunctional peptidase and arginyl-hydroxylase JMJD5 OS=Bos taurus OX=9913 GN=KDM8 PE=4 SV=1 CANONICAL=A0AAF6Z716-1" }, "locus": { "chromosome": "25", "start_pos": 24803232, "end_pos": 24790460, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026023.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026023.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026023.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026023.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "histone H3K36 demethylase activity", "id": "GO:0051864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051864", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "endopeptidase activity", "id": "GO:0004175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "aminopeptidase activity", "id": "GO:0004177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004177", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "peptidyl-arginine 3-dioxygenase activity", "id": "GO:0106157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106157", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "G2/M transition of mitotic cell cycle", "id": "GO:0000086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "circadian regulation of gene expression", "id": "GO:0032922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032922", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" }, { "name": "protein destabilization", "id": "GO:0031648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z716", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "56744", "name": "", "equation": "L-arginyl-[protein] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JP61-1", "A0AAF6Z716-1" ], "evidence": [ { "id": "56744", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56744" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z716", "gene_name": "KDM8", "activity": [ { "ec_number": "1.14.11.73", "activity": "L-arginyl-[protein] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + succinate + CO2.", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ] }, { "ec_number": "1.14.11.73", "activity": "", "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" } ] } ] }, { "uniprot_ac": "Q1JP61", "gene_name": "KDM8", "activity": [ { "ec_number": "3.4.-.-", "activity": "", "evidence": [ { "id": "Q1JP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP61" } ] }, { "ec_number": "1.14.11.73", "activity": "L-arginyl-[protein] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + succinate + CO2.", "evidence": [ { "id": "Q1JP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP61" } ] }, { "ec_number": "1.14.11.73", "activity": "", "evidence": [ { "id": "Q1JP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP61" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" }, { "id": "PF13621", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13621" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cupin-like", "eco_id": "ECO_0000259", "start_pos": 185, "end_pos": 365, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z716" }, { "id": "PF24472", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24472" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DM8", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 127, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.11.73", "ec_name": "L-arginyl-[protein] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + succinate + CO2.", "evidence": [ { "id": "1.14.11.73", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.73" }, { "id": "1.14.11.73", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.11.73" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 349, "end_pos": 351 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z723-1", "uniprot_ac": "A0AAF6Z723", "uniprot_id": "A0AAF6Z723_BOVIN", "mass": { "chemical_mass": 22471.0, "monoisotopic_mass": 22471.0 }, "refseq": {}, "gene_names": [ { "name": "SNRNP25", "type": "recommended", "evidence": [ { "id": "A0AAF6Z723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723" } ] } ], "protein_names": [ { "name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "type": "recommended", "evidence": [ { "id": "A0AAF6Z723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z723", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNRNP25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723", "locus": { "chromosome": "25", "start_pos": 120817, "end_pos": 118409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019804", "url": "https://www.ensembl.org/id/ENSBTAG00000019804" } ] } } ], "crossref": [ { "id": "A0AAF6Z723", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z723", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17058", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17058", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14942", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14942", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14942:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14942:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z723", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z723-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPPAPRRWGYRSGPGACAIASVAWSRCAGEAGWKPGALEEPRVVARPEPQDDEEDEEEALPHSEAVDVFQEGLAMVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLRQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 199, "header": "tr|A0AAF6Z723-1|A0AAF6Z723_BOVIN Isoform 1 of U11/U12 small nuclear ribonucleoprotein 25 kDa protein OS=Bos taurus OX=9913 GN=SNRNP25 PE=4 SV=1 CANONICAL=A0AAF6Z723-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z723-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723/entry", "sequence": { "sequence": "MAPPPAPRRWGYRSGPGACAIASVAWSRCAGEAGWKPGALEEPRVVARPEPQDDEEDEEEALPHSEAVDVFQEGLAMVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLRQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK", "length": 199, "header": "tr|A0AAF6Z723-1|A0AAF6Z723_BOVIN Isoform 1 of U11/U12 small nuclear ribonucleoprotein 25 kDa protein OS=Bos taurus OX=9913 GN=SNRNP25 PE=4 SV=1 CANONICAL=A0AAF6Z723-1" }, "locus": { "chromosome": "25", "start_pos": 120616, "end_pos": 118608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026387.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026387.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026387.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026387.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z723", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z723", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z723" }, { "id": "PF18036", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18036" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SNRNP25 ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 199, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z733-1", "uniprot_ac": "A0AAF6Z733", "uniprot_id": "A0AAF6Z733_BOVIN", "mass": { "chemical_mass": 143172.0, "monoisotopic_mass": 143172.0 }, "refseq": {}, "gene_names": [ { "name": "DHX9", "type": "recommended", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ], "protein_names": [ { "name": "ATP-dependent RNA helicase A", "type": "recommended", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733/entry#names_and_taxonomy" } ] }, { "name": "DEAH box protein 9", "type": "synonym", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733/entry#names_and_taxonomy" } ] }, { "name": "Nuclear DNA helicase II", "type": "synonym", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733", "locus": { "chromosome": "16", "start_pos": 63937888, "end_pos": 63896685, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019821", "url": "https://www.ensembl.org/id/ENSBTAG00000019821" } ] } } ], "crossref": [ { "id": "cd17972", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17972", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18791", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19854", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19854", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19855", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19855", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934:SF119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934:SF119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04408", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z733-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVRVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINELKSEEVPAVGVAPPTPSATDSSDTTAEDGGVPGNLGGPLPPHLTLQAENNSGGGGSGYVPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQIGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVIEPYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIVQELNLEIVPIPEDPSVPVALNLGKLAQFEPSQRQNPVGVVPWSPPQSNWNPWTSSNIDEGPLAYATPEQISMDLKNELMYQLEQDRDLQAVLQERELLPVKKFESEILEAISQNPVVIIRGATGCGKTTQVPQFILDDCIQNDRAAECNIVVTQHLNHFFCLSQPRRISAVSVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTFPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGAETRISMAQLNEKETPFELIEALLLYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPSGVTKIILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTISAATCFPEPFISEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEECLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQLVLVDDWIRLQISHEAAACITALRAAMEALVVEVTKQPGIISQLDPVNERMLNTIRQISRPSAAGINLMIGTTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGLGGYGTGGYGGGGGYGGRGGYSGGGYGGGSNSFRGSYVGGGGGVGGGGGGFRGLSRGGYRGMSGGDYRGESGGGYRGSGGFQRGGGRGGYGGGYFGQGRGGGGY", "length": 1297, "header": "tr|A0AAF6Z733-1|A0AAF6Z733_BOVIN Isoform 1 of ATP-dependent RNA helicase A OS=Bos taurus OX=9913 GN=DHX9 PE=3 SV=1 CANONICAL=A0AAF6Z733-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z733-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733/entry", "sequence": { "sequence": "MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVRVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINELKSEEVPAVGVAPPTPSATDSSDTTAEDGGVPGNLGGPLPPHLTLQAENNSGGGGSGYVPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQIGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVIEPYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIVQELNLEIVPIPEDPSVPVALNLGKLAQFEPSQRQNPVGVVPWSPPQSNWNPWTSSNIDEGPLAYATPEQISMDLKNELMYQLEQDRDLQAVLQERELLPVKKFESEILEAISQNPVVIIRGATGCGKTTQVPQFILDDCIQNDRAAECNIVVTQHLNHFFCLSQPRRISAVSVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTFPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGAETRISMAQLNEKETPFELIEALLLYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPSGVTKIILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTISAATCFPEPFISEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEECLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQLVLVDDWIRLQISHEAAACITALRAAMEALVVEVTKQPGIISQLDPVNERMLNTIRQISRPSAAGINLMIGTTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGLGGYGTGGYGGGGGYGGRGGYSGGGYGGGSNSFRGSYVGGGGGVGGGGGGFRGLSRGGYRGMSGGDYRGESGGGYRGSGGFQRGGGRGGYGGGYFGQGRGGGGY", "length": 1297, "header": "tr|A0AAF6Z733-1|A0AAF6Z733_BOVIN Isoform 1 of ATP-dependent RNA helicase A OS=Bos taurus OX=9913 GN=DHX9 PE=3 SV=1 CANONICAL=A0AAF6Z733-1" }, "locus": { "chromosome": "16", "start_pos": 63937362, "end_pos": 63900304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026409.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026409.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026409.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026409.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 89, "start_aa": "Thr", "end_pos": 89, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "cellular response to exogenous dsRNA", "id": "GO:0071360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071360", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "protein localization to cytoplasmic stress granule", "id": "GO:1903608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903608", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "DNA-templated viral transcription", "id": "GO:0039695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039695", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of RNA export from nucleus", "id": "GO:0046833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046833", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of response to cytokine stimulus", "id": "GO:0060760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060760", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RISC complex assembly", "id": "GO:0070922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070922", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "CRD-mediated mRNA stabilization", "id": "GO:0070934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070934", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of cytoplasmic translation", "id": "GO:2000767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000767", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of fibroblast proliferation", "id": "GO:0048146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048146", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "miRNA-mediated post-transcriptional gene silencing", "id": "GO:0035195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035195", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "DNA-templated transcription termination", "id": "GO:0006353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006353", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of viral transcription", "id": "GO:0050434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050434", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "alternative mRNA splicing, via spliceosome", "id": "GO:0000380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "regulation of mRNA processing", "id": "GO:0050684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050684", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "id": "GO:1900152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900152", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 26, "go_terms": [ { "name": "DNA replication origin binding", "id": "GO:0003688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003688", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "regulatory region RNA binding", "id": "GO:0001069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001069", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "triplex DNA binding", "id": "GO:0045142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045142", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "importin-alpha family protein binding", "id": "GO:0061676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061676", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RISC complex binding", "id": "GO:1905172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905172", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "single-stranded 3'-5' DNA helicase activity", "id": "GO:1990518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990518", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "sequence-specific mRNA binding", "id": "GO:1990825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990825", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "siRNA binding", "id": "GO:0035197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "nucleoside triphosphate diphosphatase activity", "id": "GO:0047429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047429", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "3'-5' RNA helicase activity", "id": "GO:0034458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034458", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RNA stem-loop binding", "id": "GO:0035613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035613", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "3'-5' DNA/RNA helicase activity", "id": "GO:0033679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033679", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "G-quadruplex unwinding activity", "id": "GO:0160225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160225", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "perichromatin fibrils", "id": "GO:0005726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005726", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "nuclear stress granule", "id": "GO:0097165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097165", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RISC complex", "id": "GO:0016442", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016442", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "RISC-loading complex", "id": "GO:0070578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070578", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" }, { "name": "CRD-mediated mRNA stability complex", "id": "GO:0070937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070937", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z733", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1176, "end_pos": 1178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 751, "end_pos": 753, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" }, { "id": "PS50137", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50137" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DRBM", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 71, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 395, "end_pos": 571, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 643, "end_pos": 816, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.4.13", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13" }, { "id": "3.6.4.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.13" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 89 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1176, "end_pos": 1178 }, { "start_pos": 123, "end_pos": 125 }, { "start_pos": 172, "end_pos": 174 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 274, "end_pos": 276 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 751, "end_pos": 753 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7C4-1", "uniprot_ac": "A0AAF6Z7C4", "uniprot_id": "A0AAF6Z7C4_BOVIN", "mass": { "chemical_mass": 16972.0, "monoisotopic_mass": 16972.0 }, "refseq": {}, "gene_names": [ { "name": "YPEL", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4" } ] }, { "name": "YPEL2", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4" } ] } ], "protein_names": [ { "name": "Protein yippee-like", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7C4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YPEL", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z7C4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7C4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z7C4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TAFTCVFRCFPCDPSCGSASWATPEFTPGSAAPMVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 152, "header": "tr|A0AAF6Z7C4-1|A0AAF6Z7C4_BOVIN Isoform 1 of Protein yippee-like OS=Bos taurus OX=9913 GN=YPEL PE=3 SV=1 CANONICAL=A0AAF6Z7C4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z7C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4/entry", "sequence": { "sequence": "TAFTCVFRCFPCDPSCGSASWATPEFTPGSAAPMVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD", "length": 152, "header": "tr|A0AAF6Z7C4-1|A0AAF6Z7C4_BOVIN Isoform 1 of Protein yippee-like OS=Bos taurus OX=9913 GN=YPEL PE=3 SV=1 CANONICAL=A0AAF6Z7C4-1" }, "locus": { "chromosome": "19", "start_pos": 10362442, "end_pos": 10323197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026389.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026389.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026389.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026389.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7C4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7C4" }, { "id": "PS51792", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51792" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Yippee", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 149, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7F8-1", "uniprot_ac": "A0AAF6Z7F8", "uniprot_id": "A0AAF6Z7F8_BOVIN", "mass": { "chemical_mass": 51155.0, "monoisotopic_mass": 51155.0 }, "refseq": {}, "gene_names": [ { "name": "LOC139029563", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8" } ] } ], "protein_names": [ { "name": "Zinc finger protein 475", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC139029563", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z7F8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7F8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026319", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026319", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13555", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13555", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13555:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13555:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13913", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13913", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z7F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEREEEKRVSTLQQSFHHSKEPTFLINQAVLFGESHSSFLPEIERDNRGEKIKTNPRKNRPGTVILSKQSSRRIMSGSQPRPPVIPSRRPGFRVCYICGREFGSQSLGIHEPQCLEKWRVENSKLPKHLRRPEPSKPPPFSGSGSYSLQAANEAAFQSSQAQLLPCETCGRTFLPDRLLVHQRSCKQKVEGPRAPSLDRSDDLAGLKKVSSGITTRPRTVICYICGREFGTLSLPIHEPKCLEKWKVENDRLPREFRQPLPQKPQPLLTGQPKHAGPRQGQLVSCPNCSQTFAPDRLPVHQRSCKAQPSGPKVQDLTLGSRGGLKESTNPKPQRNMAAPPVTDKPTMIRRPPTIVCYICGREYGTKSIAIHEPQCLKKWHNENNLLPKELRRPEPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCNICGRTFLPDRLIVHQRSCKPKVAK", "length": 454, "header": "tr|A0AAF6Z7F8-1|A0AAF6Z7F8_BOVIN Isoform 1 of Zinc finger protein 475 OS=Bos taurus OX=9913 GN=LOC139029563 PE=4 SV=2 CANONICAL=A0AAF6Z7F8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z7F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8/entry", "sequence": { "sequence": "MEREEEKRVSTLQQSFHHSKEPTFLINQAVLFGESHSSFLPEIERDNRGEKIKTNPRKNRPGTVILSKQSSRRIMSGSQPRPPVIPSRRPGFRVCYICGREFGSQSLGIHEPQCLEKWRVENSKLPKHLRRPEPSKPPPFSGSGSYSLQAANEAAFQSSQAQLLPCETCGRTFLPDRLLVHQRSCKQKVEGPRAPSLDRSDDLAGLKKVSSGITTRPRTVICYICGREFGTLSLPIHEPKCLEKWKVENDRLPREFRQPLPQKPQPLLTGQPKHAGPRQGQLVSCPNCSQTFAPDRLPVHQRSCKAQPSGPKVQDLTLGSRGGLKESTNPKPQRNMAAPPVTDKPTMIRRPPTIVCYICGREYGTKSIAIHEPQCLKKWHNENNLLPKELRRPEPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCNICGRTFLPDRLIVHQRSCKPKVAK", "length": 454, "header": "tr|A0AAF6Z7F8-1|A0AAF6Z7F8_BOVIN Isoform 1 of Zinc finger protein 475 OS=Bos taurus OX=9913 GN=LOC139029563 PE=4 SV=2 CANONICAL=A0AAF6Z7F8-1" }, "locus": { "chromosome": "7", "start_pos": 31668510, "end_pos": 31639246, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026489.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026489.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026489.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026489.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7F8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7F8" }, { "id": "PS52027", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52027" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2HC/C3H-type", "eco_id": "ECO_0000259", "start_pos": 91, "end_pos": 120, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 287, "end_pos": 289 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7G1-1", "uniprot_ac": "A0AAF6Z7G1", "uniprot_id": "A0AAF6Z7G1_BOVIN", "mass": { "chemical_mass": 46107.0, "monoisotopic_mass": 46107.0 }, "refseq": {}, "gene_names": [ { "name": "RPL7", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL30", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L7", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1#function" }, { "database": "UniProtKB", "id": "ARBA00045415", "url": "https://www.uniprot.org/uniprotkb/ARBA00045415#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z7G1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7G1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01657", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01657", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11524", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11524", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11524:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11524:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLIRGQIPLAEAWAAGGRVLFLESRTGCDSGVPAPSGGGRGGGKRLDPTMPRAPVRVTLQRRGVGRLQVAVDVAHHARRLLVALGVDVPEHQQRPASGELEREEAAQAAAGARNEAHLAGHALLLGPHQPARSGQHERPKHFESDHEELHHDVHRDVPGEPQEKKKKVPAVPETLKKKRKNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 406, "header": "tr|A0AAF6Z7G1-1|A0AAF6Z7G1_BOVIN Isoform 1 of Large ribosomal subunit protein uL30 OS=Bos taurus OX=9913 GN=RPL7 PE=3 SV=1 CANONICAL=A0AAF6Z7G1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z7G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1/entry", "sequence": { "sequence": "MPLIRGQIPLAEAWAAGGRVLFLESRTGCDSGVPAPSGGGRGGGKRLDPTMPRAPVRVTLQRRGVGRLQVAVDVAHHARRLLVALGVDVPEHQQRPASGELEREEAAQAAAGARNEAHLAGHALLLGPHQPARSGQHERPKHFESDHEELHHDVHRDVPGEPQEKKKKVPAVPETLKKKRKNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 406, "header": "tr|A0AAF6Z7G1-1|A0AAF6Z7G1_BOVIN Isoform 1 of Large ribosomal subunit protein uL30 OS=Bos taurus OX=9913 GN=RPL7 PE=3 SV=1 CANONICAL=A0AAF6Z7G1-1" }, "locus": { "chromosome": "14", "start_pos": 36629162, "end_pos": 36624428, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026826.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026826.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026826.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026826.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1" }, { "id": "PF08079", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08079" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL30 N-terminal eukaryota", "eco_id": "ECO_0000259", "start_pos": 172, "end_pos": 243, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7G1" }, { "id": "PF00327", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00327" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL30-like ferredoxin-like fold", "eco_id": "ECO_0000259", "start_pos": 248, "end_pos": 298, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7L1-1", "uniprot_ac": "A0AAF6Z7L1", "uniprot_id": "A0AAF6Z7L1_BOVIN", "mass": { "chemical_mass": 35851.0, "monoisotopic_mass": 35851.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ubiquitin thioesterase OTU", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1#function" }, { "database": "UniProtKB", "id": "RU367104", "url": "https://www.uniprot.org/uniprotkb/RU367104#function" }, { "database": "UniProtKB", "id": "ARBA00059047", "url": "https://www.uniprot.org/uniprotkb/ARBA00059047#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1", "locus": {} } ], "crossref": [ { "id": "A0AAF6Z7L1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7L1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22745", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22745", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13312", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13312", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13312:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13312:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02338", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02338", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDCGNKSPLRSVGFAALRPGWTKNNAYVFLRREGLSSRTRVRELQGQIAAITGISPGCQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIVEEDQNRPKTSPAFTKYGAPSYVRETLPVLARMAVPADNSCLFTSVYYVVEGGVLNPACAPEMRRFIAQIVASDPDFYSEAILGKTNEEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLHLVFPDPDTPPLTIFSSYDDIVLVQALELADEARKKRQFTDVNRFTLRCMVCQKGLTGQAEARDHAKETGHTNFGEV", "length": 321, "header": "tr|A0AAF6Z7L1-1|A0AAF6Z7L1_BOVIN Isoform 1 of Ubiquitin thioesterase OTU OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6Z7L1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z7L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1/entry", "sequence": { "sequence": "MLDCGNKSPLRSVGFAALRPGWTKNNAYVFLRREGLSSRTRVRELQGQIAAITGISPGCQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIVEEDQNRPKTSPAFTKYGAPSYVRETLPVLARMAVPADNSCLFTSVYYVVEGGVLNPACAPEMRRFIAQIVASDPDFYSEAILGKTNEEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLHLVFPDPDTPPLTIFSSYDDIVLVQALELADEARKKRQFTDVNRFTLRCMVCQKGLTGQAEARDHAKETGHTNFGEV", "length": 321, "header": "tr|A0AAF6Z7L1-1|A0AAF6Z7L1_BOVIN Isoform 1 of Ubiquitin thioesterase OTU OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAF6Z7L1-1" }, "locus": { "chromosome": "16", "start_pos": 4872957, "end_pos": 4869826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027017.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027017.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027017.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027017.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "K48-linked deubiquitinase activity", "id": "GO:1990380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "protein K63-linked deubiquitination", "id": "GO:0070536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070536", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "protein K48-linked deubiquitination", "id": "GO:0071108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071108", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "negative regulation of retrograde protein transport, ER to cytosol", "id": "GO:1904153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904153", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "protein K29-linked deubiquitination", "id": "GO:0035523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035523", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "protein K27-linked deubiquitination", "id": "GO:1990167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990167", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "protein K33-linked deubiquitination", "id": "GO:1990168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990168", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" }, { "name": "protein K11-linked deubiquitination", "id": "GO:0035871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035871", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7L1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z7L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7L1" }, { "id": "PS50802", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50802" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OTU", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 247, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7N5-1", "uniprot_ac": "A0AAF6Z7N5", "uniprot_id": "A0AAF6Z7N5_BOVIN", "mass": { "chemical_mass": 16407.0, "monoisotopic_mass": 16407.0 }, "refseq": {}, "gene_names": [ { "name": "PFDN2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ] } ], "protein_names": [ { "name": "Prefoldin subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5#function" }, { "database": "UniProtKB", "id": "ARBA00024667", "url": "https://www.uniprot.org/uniprotkb/ARBA00024667#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PFDN2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5", "locus": { "chromosome": "3", "start_pos": 8389749, "end_pos": 8376916, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020152", "url": "https://www.ensembl.org/id/ENSBTAG00000020152" } ] } } ], "crossref": [ { "id": "A0AAF6Z7N5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7N5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13303", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13303", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENGGRAGKSSGSGTGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQKIIETLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS", "length": 152, "header": "tr|A0AAF6Z7N5-1|A0AAF6Z7N5_BOVIN Isoform 1 of Prefoldin subunit 2 OS=Bos taurus OX=9913 GN=PFDN2 PE=3 SV=1 CANONICAL=A0AAF6Z7N5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z7N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5/entry", "sequence": { "sequence": "MAENGGRAGKSSGSGTGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQKIIETLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS", "length": 152, "header": "tr|A0AAF6Z7N5-1|A0AAF6Z7N5_BOVIN Isoform 1 of Prefoldin subunit 2 OS=Bos taurus OX=9913 GN=PFDN2 PE=3 SV=1 CANONICAL=A0AAF6Z7N5-1" }, "locus": { "chromosome": "3", "start_pos": 8388745, "end_pos": 8376927, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026841.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026841.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026841.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026841.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of cytoskeleton organization", "id": "GO:0051495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051495", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" }, { "name": "negative regulation of amyloid fibril formation", "id": "GO:1905907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905907", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" }, { "name": "prefoldin complex", "id": "GO:0016272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016272", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" }, { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7N5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z7Y5-1", "uniprot_ac": "A0AAF6Z7Y5", "uniprot_id": "A0AAF6Z7Y5_BOVIN", "mass": { "chemical_mass": 17176.0, "monoisotopic_mass": 17176.0 }, "refseq": { "ac": "XP_015313666", "name": "apolipoprotein C-II isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313666" }, "gene_names": [ { "name": "APOC2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ] }, { "name": "APOC2", "type": "synonym", "evidence": [ { "id": "XP_015313666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313666" } ] } ], "protein_names": [ { "name": "Apolipoprotein C-II", "type": "recommended", "evidence": [ { "id": "A0AAF6Z7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5/entry#names_and_taxonomy" } ] }, { "name": "Apo-CII", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5/entry#names_and_taxonomy" } ] }, { "name": "ApoC-II", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5/entry#names_and_taxonomy" } ] }, { "name": "Apolipoprotein C2", "type": "synonym", "evidence": [ { "id": "A0AAF6Z7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5/entry#names_and_taxonomy" } ] }, { "name": "apolipoprotein C-II isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015313666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313666" } ] } ], "function": [ { "annotation": "Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5#function" }, { "database": "UniProtKB", "id": "RU368054", "url": "https://www.uniprot.org/uniprotkb/RU368054#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "APOC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5", "locus": { "chromosome": "18", "start_pos": 52657197, "end_pos": 52654626, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020558", "url": "https://www.ensembl.org/id/ENSBTAG00000020558" } ] } } ], "crossref": [ { "id": "A0AAF6Z7Y5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z7Y5", "database": "AlphaFoldDB", "categories": [] }, { "id": "618039", "url": "https://www.ncbi.nlm.nih.gov/gene/618039", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16566", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16566", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16566:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16566:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015313666", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313666", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPPPQLSPSHPCSPVGQDFGRGVEVGVEGWISRAIKPFSAHLELLRTAARVWSPDAMGTRYFLVGFLILLVLGFEVQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPAVDEKIRDIYSKSTAAVTTYAGIITDQVFSVLSGKD", "length": 158, "header": "tr|A0AAF6Z7Y5-1|A0AAF6Z7Y5_BOVIN Isoform 1 of Apolipoprotein C-II OS=Bos taurus OX=9913 GN=APOC2 PE=3 SV=1 CANONICAL=A0AAF6Z7Y5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z7Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5/entry", "sequence": { "sequence": "MPPPPQLSPSHPCSPVGQDFGRGVEVGVEGWISRAIKPFSAHLELLRTAARVWSPDAMGTRYFLVGFLILLVLGFEVQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPAVDEKIRDIYSKSTAAVTTYAGIITDQVFSVLSGKD", "length": 158, "header": "tr|A0AAF6Z7Y5-1|A0AAF6Z7Y5_BOVIN Isoform 1 of Apolipoprotein C-II OS=Bos taurus OX=9913 GN=APOC2 PE=3 SV=1 CANONICAL=A0AAF6Z7Y5-1" }, "locus": { "chromosome": "18", "start_pos": 52657039, "end_pos": 52654825, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027393.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027393.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027393.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027393.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "high-density lipoprotein particle", "id": "GO:0034364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" }, { "name": "very-low-density lipoprotein particle", "id": "GO:0034361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034361", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" }, { "name": "chylomicron", "id": "GO:0042627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" }, { "name": "low-density lipoprotein particle", "id": "GO:0034362", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034362", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z7Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z809-1", "uniprot_ac": "A0AAF6Z809", "uniprot_id": "A0AAF6Z809_BOVIN", "mass": { "chemical_mass": 47954.0, "monoisotopic_mass": 47954.0 }, "refseq": {}, "gene_names": [ { "name": "ASS1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ] } ], "protein_names": [ { "name": "Argininosuccinate synthase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809/entry#names_and_taxonomy" } ] }, { "name": "6.3.4.5", "type": "synonym", "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809/entry#names_and_taxonomy" } ] }, { "name": "Citrulline--aspartate ligase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809", "locus": { "chromosome": "11", "start_pos": 100822222, "end_pos": 100770227, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020747", "url": "https://www.ensembl.org/id/ENSBTAG00000020747" } ] } } ], "crossref": [ { "id": "A0AAF6Z809", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z809", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01999", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01999", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11587", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11587", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11587:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11587:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00764", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00764", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10932", "url": "https://www.rhea-db.org/rhea/10932", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z809-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ATF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ATF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NT42", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NT42-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDLMEYAKQHGIPVPVTPKNPWSMDENLMHIRGLQETDLAQLGSDTLSSNLFLSYQNQAPPGLYTKTQDPAKAPNSPDMLEIEFKKGVPVKVTNVGDGTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPVDATGFININSLRLKEYHRLQNKVTAK", "length": 426, "header": "tr|A0AAF6Z809-1|A0AAF6Z809_BOVIN Isoform 1 of Argininosuccinate synthase OS=Bos taurus OX=9913 GN=ASS1 PE=3 SV=1 CANONICAL=A0AAF6Z809-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z809-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809/entry", "sequence": { "sequence": "MSGKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDLMEYAKQHGIPVPVTPKNPWSMDENLMHIRGLQETDLAQLGSDTLSSNLFLSYQNQAPPGLYTKTQDPAKAPNSPDMLEIEFKKGVPVKVTNVGDGTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPVDATGFININSLRLKEYHRLQNKVTAK", "length": 426, "header": "tr|A0AAF6Z809-1|A0AAF6Z809_BOVIN Isoform 1 of Argininosuccinate synthase OS=Bos taurus OX=9913 GN=ASS1 PE=3 SV=1 CANONICAL=A0AAF6Z809-1" }, "locus": { "chromosome": "11", "start_pos": 100822004, "end_pos": 100777947, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027649.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027649.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027649.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027649.4" } ] } }, { "isoform_ac": "A0AAF7ATF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ATF7/entry", "sequence": { "sequence": "MGPGLTMSGKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDLMEYAKQHGIPVPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNSPDMLEIEFKKGVPVKVTNVGDGTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPVDATGFININSLRLKEYHRLQNKVTAK", "length": 418, "header": "tr|A0AAF7ATF7-1|A0AAF7ATF7_BOVIN Computationally mapped isoform of Argininosuccinate synthase OS=Bos taurus OX=9913 GN=ASS1 PE=3 SV=1 CANONICAL=A0AAF6Z809-1" }, "locus": { "chromosome": "11", "start_pos": 100822004, "end_pos": 100770473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071866.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071866.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074521.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074521.2" } ] } }, { "isoform_ac": "A0ABI0NT42-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT42/entry", "sequence": { "sequence": "MRAETRPAPPTAAAAGHPANIGQKEDFEEARKKALKLGAKKVFIEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDLMEYAKQHGIPVPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNSPDMLEIEFKKGVPVKVTNVGDGTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPVDATGFININSLRLKEYHRLQNKVTAK", "length": 395, "header": "tr|A0ABI0NT42-1|A0ABI0NT42_BOVIN Computationally mapped isoform of Argininosuccinate synthase OS=Bos taurus OX=9913 GN=ASS1 PE=3 SV=1 CANONICAL=A0AAF6Z809-1" }, "locus": { "chromosome": "11", "start_pos": 100822004, "end_pos": 100770211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154703.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154703.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106350.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106350.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "amino acid binding", "id": "GO:0016597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016597", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "argininosuccinate synthase activity", "id": "GO:0004055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004055", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of nitric oxide biosynthetic process", "id": "GO:0045429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045429", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "aspartate metabolic process", "id": "GO:0006531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006531", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "urea cycle", "id": "GO:0000050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000050", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "citrulline metabolic process", "id": "GO:0000052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000052", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "argininosuccinate metabolic process", "id": "GO:0000053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000053", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "L-arginine biosynthetic process", "id": "GO:0006526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006526", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "cellular response to laminar fluid shear stress", "id": "GO:0071499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071499", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" }, { "name": "negative regulation of leukocyte cell-cell adhesion", "id": "GO:1903038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903038", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z809", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10932", "name": "", "equation": "L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z809-1", "P14568-1" ], "evidence": [ { "id": "10932", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10932" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6Z809", "gene_name": "ASS1", "activity": [ { "ec_number": "6.3.4.5", "activity": "L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ] }, { "ec_number": "6.3.4.5", "activity": "", "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" } ] } ] }, { "uniprot_ac": "P14568", "gene_name": "ASS1", "activity": [ { "ec_number": "6.3.4.5", "activity": "L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+).", "evidence": [ { "id": "P14568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14568" } ] }, { "ec_number": "6.3.4.5", "activity": "", "evidence": [ { "id": "P14568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14568" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" }, { "id": "PF20979", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20979" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arginosuccinate synthase C-terminal", "eco_id": "ECO_0000259", "start_pos": 211, "end_pos": 416, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z809" }, { "id": "PF00764", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00764" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arginosuccinate synthase-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 170, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.4.5", "ec_name": "L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.3.4.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.5" }, { "id": "6.3.4.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z870-1", "uniprot_ac": "A0AAF6Z870", "uniprot_id": "A0AAF6Z870_BOVIN", "mass": { "chemical_mass": 40491.0, "monoisotopic_mass": 40491.0 }, "refseq": {}, "gene_names": [ { "name": "SLC16A13", "type": "recommended", "evidence": [ { "id": "A0AAF6Z870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870" } ] } ], "protein_names": [ { "name": "Monocarboxylate transporter 13", "type": "recommended", "evidence": [ { "id": "A0AAF6Z870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 16 member 13", "type": "synonym", "evidence": [ { "id": "A0AAF6Z870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z870", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870#function" }, { "database": "UniProtKB", "id": "ARBA00059080", "url": "https://www.uniprot.org/uniprotkb/ARBA00059080#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z870", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC16A13", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870", "locus": { "chromosome": "19", "start_pos": 26824916, "end_pos": 26821869, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020853", "url": "https://www.ensembl.org/id/ENSBTAG00000020853" } ] } } ], "crossref": [ { "id": "A0AAF6Z870", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z870", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17423", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17423", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11360", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11360:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z870", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z870-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYRAEPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGKGNKISRWAMAAVFYHGGCRGELI", "length": 385, "header": "tr|A0AAF6Z870-1|A0AAF6Z870_BOVIN Isoform 1 of Monocarboxylate transporter 13 OS=Bos taurus OX=9913 GN=SLC16A13 PE=3 SV=1 CANONICAL=A0AAF6Z870-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z870-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870/entry", "sequence": { "sequence": "MAYRAEPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEPAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPAVMTGGILTALGMLLASFATSLTHLYLSIGLLSGSGWALTFTPTLACLSRYFSRRRSLAMGLALTGVGLSSFAFAPLFQWLLNHYAWRGALLLVSALSLHLVACGALLRPLSLAEDPVVGGPGAQITSLLRHGPFLRYTVALTLINTGYFIPYVHLVAHLRDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVILALYPVAEAPTGLVALTMAYGFTSGALTPVAFSVLPELVGTGKIYCGLGLVQMVESIGGLLGAPLSGKGNKISRWAMAAVFYHGGCRGELI", "length": 385, "header": "tr|A0AAF6Z870-1|A0AAF6Z870_BOVIN Isoform 1 of Monocarboxylate transporter 13 OS=Bos taurus OX=9913 GN=SLC16A13 PE=3 SV=1 CANONICAL=A0AAF6Z870-1" }, "locus": { "chromosome": "19", "start_pos": 26823912, "end_pos": 26821970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027786.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027786.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027786.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027786.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z870", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z870", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z870", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z870" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 385, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8C2-1", "uniprot_ac": "A0AAF6Z8C2", "uniprot_id": "A0AAF6Z8C2_BOVIN", "mass": { "chemical_mass": 52017.0, "monoisotopic_mass": 52017.0 }, "refseq": {}, "gene_names": [ { "name": "ACP1", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ], "protein_names": [ { "name": "Low molecular weight phosphotyrosine protein phosphatase", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.2", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2/entry#names_and_taxonomy" } ] }, { "name": "Low molecular weight cytosolic acid phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8C2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACP1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2", "locus": { "chromosome": "8", "start_pos": 112748923, "end_pos": 112764437, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020498", "url": "https://www.ensembl.org/id/ENSBTAG00000020498" } ] } } ], "crossref": [ { "id": "A0AAF6Z8C2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8C2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11717", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11717:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11717:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01451", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01451", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "15017", "url": "https://www.rhea-db.org/rhea/15017", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z8C2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRA8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRA8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2A9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2A9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2A9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H9GW34", "url": "https://www.uniprot.org/uniprotkb/H9GW34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H9GW34-1", "url": "https://www.uniprot.org/uniprotkb/H9GW34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTALKDAQQQTIPETQLLPFPPKTDPPQRDSRGPGAARGQERPAPTPLLTRDPEPGPLLRPGAVDRARAEDGRCRGSASGRGPLWAAHTWAGEAAVGGAHLGQVRGRSTRSRRGSTASYGLAVRGRARPRARNQPVVDERAAHGRRARRGPSAAIPPGGGGAPGLGRREWTRPRGRPSRAGGGSLTRAHLSALQGPEGTERAPSRPRRAGFALRLREPLQPGATPSPAPAVTRRPEPRSSPAPSPLRWLSAPPRRPLPHGLQVARGSASSRGAGPDCASAKPPARPGGRRRTTQAHGRAARSAHAPRRKRSDVITGRLCASGKMAEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNISDNWVIDSGAVSDWNVGRSPDPRAVSCLRNHGINTAHKARQVTKEDFVTFDYILCMDESNLRDLNRKSNQVKNCRAKIELLGSYDPQKQLIIEDPYYGNDADFETVYQQCVRCCRAFLEKVR", "length": 481, "header": "tr|A0AAF6Z8C2-1|A0AAF6Z8C2_BOVIN Isoform 1 of Low molecular weight phosphotyrosine protein phosphatase OS=Bos taurus OX=9913 GN=ACP1 PE=3 SV=1 CANONICAL=A0AAF6Z8C2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2/entry", "sequence": { "sequence": "MTALKDAQQQTIPETQLLPFPPKTDPPQRDSRGPGAARGQERPAPTPLLTRDPEPGPLLRPGAVDRARAEDGRCRGSASGRGPLWAAHTWAGEAAVGGAHLGQVRGRSTRSRRGSTASYGLAVRGRARPRARNQPVVDERAAHGRRARRGPSAAIPPGGGGAPGLGRREWTRPRGRPSRAGGGSLTRAHLSALQGPEGTERAPSRPRRAGFALRLREPLQPGATPSPAPAVTRRPEPRSSPAPSPLRWLSAPPRRPLPHGLQVARGSASSRGAGPDCASAKPPARPGGRRRTTQAHGRAARSAHAPRRKRSDVITGRLCASGKMAEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNISDNWVIDSGAVSDWNVGRSPDPRAVSCLRNHGINTAHKARQVTKEDFVTFDYILCMDESNLRDLNRKSNQVKNCRAKIELLGSYDPQKQLIIEDPYYGNDADFETVYQQCVRCCRAFLEKVR", "length": 481, "header": "tr|A0AAF6Z8C2-1|A0AAF6Z8C2_BOVIN Isoform 1 of Low molecular weight phosphotyrosine protein phosphatase OS=Bos taurus OX=9913 GN=ACP1 PE=3 SV=1 CANONICAL=A0AAF6Z8C2-1" }, "locus": { "chromosome": "8", "start_pos": 112764238, "end_pos": 112749783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027314.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027314.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027314.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027314.5" } ] } }, { "isoform_ac": "A0ABI0NRA8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRA8/entry", "sequence": { "sequence": "DERAAHGRRARRGPSAAIPPGGGGAPGLGRREWTRPRGRPSRAGGGSLTRAHLSALQGPEGTERAPSRPRRAGFALRLREPLQPGATPSPAPAVTRRPEPRSSPAPSPLRWLSAPPRRPLPHGLQVARGSASSRGAGPDCASAKPPARPGGRRRTTQAHGRAARSAHAPRRKRSDVITGRLCASGKMAEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNISDNWRIDSAATSTYELGNPPDFRGQACMRKHGIPMSHVARQVTKEDFVTFDYILCMDESNLRATTPTLRPSTSSACGAAGPSWRRCADRPSRCGPGSSPQAVCPVSTVSPFRAKAAALSSVDSLFPT", "length": 349, "header": "tr|A0ABI0NRA8-1|A0ABI0NRA8_BOVIN Computationally mapped isoform of Low molecular weight phosphotyrosine protein phosphatase OS=Bos taurus OX=9913 GN=ACP1 PE=3 SV=1 CANONICAL=A0AAF6Z8C2-1" }, "locus": { "chromosome": "8", "start_pos": 112763827, "end_pos": 112749662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139669.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139669.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105113.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105113.1" } ] } }, { "isoform_ac": "A0ABI0P2A9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2A9/entry", "sequence": { "sequence": "MAEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNISDNWRIDSAATSTGSLTVALFLTGTWAGHQIQEL", "length": 70, "header": "tr|A0ABI0P2A9-1|A0ABI0P2A9_BOVIN Computationally mapped isoform of Acid phosphatase 1 OS=Bos taurus OX=9913 GN=ACP1 PE=4 SV=1 CANONICAL=A0AAF6Z8C2-1" }, "locus": { "chromosome": "8", "start_pos": 112763269, "end_pos": 112758631, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140284.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140284.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104668.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104668.1" } ] } }, { "isoform_ac": "H9GW34-1", "url": "https://www.uniprot.org/uniprotkb/H9GW34/entry", "sequence": { "sequence": "MTALKDAQQQTIPETQLLPFPPKTDPPQRDSRGPGAARGQERPAPTPLLTRDPEPGPLLRPGAVDRARAEDGRCRGSASGRGPLWAAHTWAGEAAVGGAHLGQVRGRSTRSRRGSTASYGLAVRGRARPRARNQPVVDERAAHGRRARRGPSAAIPPGGGGAPGLGRREWTRPRGRPSRAGGGSLTRAHLSALQGPEGTERAPSRPRRAGFALRLREPLQPGATPSPAPAVTRRPEPRSSPAPSPLRWLSAPPRRPLPHGLQVARGSASSRGAGPDCASAKPPARPGGRRRTTQAHGRAARSAHAPRRKRSDVITGRLCASGKMAEQVTKSVLFVCLGNICRSPIAEAVFRKLVTDQNISDNWRIDSAATSTYELGNPPDFRGQACMRKHGIPMSHVARQVTKEDFVTFDYILCMDESNLRDLNRKSNQVKNCRAKIELLGSYDPQKQLIIEDPYYGNDADFETVYQQCVRCCRAFLEKVR", "length": 481, "header": "tr|H9GW34-1|H9GW34_BOVIN Computationally mapped isoform of Low molecular weight phosphotyrosine protein phosphatase OS=Bos taurus OX=9913 GN=ACP1 PE=3 SV=1 CANONICAL=A0AAF6Z8C2-1" }, "locus": { "chromosome": "8", "start_pos": 112764238, "end_pos": 112749783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050657.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050657.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047327.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047327.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 224, "start_aa": "Thr", "end_pos": 224, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr224", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 46, "start_aa": "Thr", "end_pos": 46, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr46", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8C2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "acid phosphatase activity", "id": "GO:0003993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003993", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8C2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ], "pmid": "" }, { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8C2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "15017", "name": "", "equation": "a phosphate monoester + H2O = an alcohol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z8C2-1", "F1MUZ7-1", "E1B8A0-1", "A0AAF6Z8S7-1", "P09487-1", "A6H730-1", "P19111-1", "P11064-1", "A0A3Q1MCB1-1", "Q0P5F0-1", "A0A3Q1LSG5-1", "A0AAA9T5N9-1", "A0A3Q1N8V6-1", "A6H757-1" ], "evidence": [ { "id": "15017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15017" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LSG5", "gene_name": "LOC100125266", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] } ] }, { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MCB1", "gene_name": "", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A0AAF6Z8S7", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A6H757", "gene_name": "ACP6", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1B8A0", "gene_name": "ACP5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "E1B8A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8A0" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "E1B8A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8A0" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MUZ7", "gene_name": "ACP7", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1MUZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUZ7" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "F1MUZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUZ7" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "P19111", "gene_name": "ALPI", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P19111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19111" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P19111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19111" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0P5F0", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q0P5F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F0" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q0P5F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F0" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" }, { "id": "SM00226", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00226" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphotyrosine protein phosphatase I", "eco_id": "ECO_0000259", "start_pos": 330, "end_pos": 479, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.2", "ec_name": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "3.1.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2" }, { "id": "3.1.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.2" } ] }, { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 46, 224 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 358, "end_pos": 360 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8I1-1", "uniprot_ac": "A0AAF6Z8I1", "uniprot_id": "A0AAF6Z8I1_BOVIN", "mass": { "chemical_mass": 27609.0, "monoisotopic_mass": 27609.0 }, "refseq": {}, "gene_names": [ { "name": "PSMA5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ] } ], "protein_names": [ { "name": "Proteasome subunit alpha type-5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1#function" }, { "database": "UniProtKB", "id": "ARBA00003876", "url": "https://www.uniprot.org/uniprotkb/ARBA00003876#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMA5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1", "locus": { "chromosome": "3", "start_pos": 34033681, "end_pos": 34012388, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020641", "url": "https://www.ensembl.org/id/ENSBTAG00000020641" } ] } } ], "crossref": [ { "id": "A0AAF6Z8I1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03753", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03753", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10584", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10584", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGERAAGVASARAAGRVALVVWRCGGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI", "length": 256, "header": "tr|A0AAF6Z8I1-1|A0AAF6Z8I1_BOVIN Isoform 1 of Proteasome subunit alpha type-5 OS=Bos taurus OX=9913 GN=PSMA5 PE=3 SV=1 CANONICAL=A0AAF6Z8I1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1/entry", "sequence": { "sequence": "MGERAAGVASARAAGRVALVVWRCGGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI", "length": 256, "header": "tr|A0AAF6Z8I1-1|A0AAF6Z8I1_BOVIN Isoform 1 of Proteasome subunit alpha type-5 OS=Bos taurus OX=9913 GN=PSMA5 PE=3 SV=1 CANONICAL=A0AAF6Z8I1-1" }, "locus": { "chromosome": "3", "start_pos": 34033516, "end_pos": 34012587, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027507.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027507.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027507.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027507.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "pmid": "" }, { "name": "proteasome core complex, alpha-subunit complex", "id": "GO:0019773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019773", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8I1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8I1" }, { "id": "SM00948", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00948" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Proteasome alpha-type subunits", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 45, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 226, "end_pos": 228 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8P9-1", "uniprot_ac": "A0AAF6Z8P9", "uniprot_id": "A0AAF6Z8P9_BOVIN", "mass": { "chemical_mass": 22708.0, "monoisotopic_mass": 22708.0 }, "refseq": {}, "gene_names": [ { "name": "PLAC9", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9" } ] } ], "protein_names": [ { "name": "Placenta associated 9", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8P9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLAC9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9", "locus": { "chromosome": "28", "start_pos": 35166730, "end_pos": 35179137, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020939", "url": "https://www.ensembl.org/id/ENSBTAG00000020939" } ] } } ], "crossref": [ { "id": "A0AAF6Z8P9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8P9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR027941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37355:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37355:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z8P9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VALLETATCWSVKWAHNGSLGLRFHHPLLCSSPGGGEGAQSAAPSWGDAQPGTSPLRSRGLWRGRARWSQKARSRPGILAGTASISSQAGRRDPGEGGEGGRRQKRRCAPPAGRMRLLLCALAGLALLRAPGAFAADEPFIPSRGDSAQSTGCDTYMAVHSRLDVIEETVEKTVEHLEAEVKGLLGQLEELAWNLPPGPFSPIPDLLGDGDDRF", "length": 214, "header": "tr|A0AAF6Z8P9-1|A0AAF6Z8P9_BOVIN Isoform 1 of Placenta associated 9 OS=Bos taurus OX=9913 GN=PLAC9 PE=4 SV=1 CANONICAL=A0AAF6Z8P9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8P9/entry", "sequence": { "sequence": "VALLETATCWSVKWAHNGSLGLRFHHPLLCSSPGGGEGAQSAAPSWGDAQPGTSPLRSRGLWRGRARWSQKARSRPGILAGTASISSQAGRRDPGEGGEGGRRQKRRCAPPAGRMRLLLCALAGLALLRAPGAFAADEPFIPSRGDSAQSTGCDTYMAVHSRLDVIEETVEKTVEHLEAEVKGLLGQLEELAWNLPPGPFSPIPDLLGDGDDRF", "length": 214, "header": "tr|A0AAF6Z8P9-1|A0AAF6Z8P9_BOVIN Isoform 1 of Placenta associated 9 OS=Bos taurus OX=9913 GN=PLAC9 PE=4 SV=1 CANONICAL=A0AAF6Z8P9-1" }, "locus": { "chromosome": "28", "start_pos": 35179107, "end_pos": 35167509, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027890.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027890.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027890.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027890.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8S8-1", "uniprot_ac": "A0AAF6Z8S8", "uniprot_id": "A0AAF6Z8S8_BOVIN", "mass": { "chemical_mass": 17800.0, "monoisotopic_mass": 17800.0 }, "refseq": {}, "gene_names": [ { "name": "IL2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ] } ], "protein_names": [ { "name": "Interleukin-2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8/entry#names_and_taxonomy" } ] }, { "name": "IL-2", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8#function" }, { "database": "UniProtKB", "id": "RU363134", "url": "https://www.uniprot.org/uniprotkb/RU363134#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8", "locus": { "chromosome": "17", "start_pos": 35222747, "end_pos": 35217965, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020883", "url": "https://www.ensembl.org/id/ENSBTAG00000020883" } ] } } ], "crossref": [ { "id": "A0AAF6Z8S8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48487", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48487", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48487:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48487:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00715", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00715", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ATMYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSRMHTFDFYVPKVNATELKHLKCLLEELKLLEEVLNLAPSKNLNPREIKDSMDNIKRIVLELQGSETRFTCEYDDATVNAVEFLNKWITFCQSIYSTMT", "length": 157, "header": "tr|A0AAF6Z8S8-1|A0AAF6Z8S8_BOVIN Isoform 1 of Interleukin-2 OS=Bos taurus OX=9913 GN=IL2 PE=3 SV=1 CANONICAL=A0AAF6Z8S8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8/entry", "sequence": { "sequence": "ATMYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSRMHTFDFYVPKVNATELKHLKCLLEELKLLEEVLNLAPSKNLNPREIKDSMDNIKRIVLELQGSETRFTCEYDDATVNAVEFLNKWITFCQSIYSTMT", "length": 157, "header": "tr|A0AAF6Z8S8-1|A0AAF6Z8S8_BOVIN Isoform 1 of Interleukin-2 OS=Bos taurus OX=9913 GN=IL2 PE=3 SV=1 CANONICAL=A0AAF6Z8S8-1" }, "locus": { "chromosome": "17", "start_pos": 35222473, "end_pos": 35218006, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027819.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027819.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027819.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027819.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "leukocyte activation involved in immune response", "id": "GO:0002366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002366", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" }, { "name": "interleukin-2-mediated signaling pathway", "id": "GO:0038110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038110", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" }, { "name": "positive regulation of interleukin-17 production", "id": "GO:0032740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032740", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via STAT", "id": "GO:0097696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097696", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" }, { "name": "interleukin-2 receptor binding", "id": "GO:0005134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005134", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8W4-1", "uniprot_ac": "A0AAF6Z8W4", "uniprot_id": "A0AAF6Z8W4_BOVIN", "mass": { "chemical_mass": 24646.0, "monoisotopic_mass": 24646.0 }, "refseq": {}, "gene_names": [ { "name": "COA8", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase assembly factor 8", "type": "synonym", "evidence": [ { "id": "A0AAF6Z8W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4", "locus": { "chromosome": "21", "start_pos": 68223503, "end_pos": 68196002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021199", "url": "https://www.ensembl.org/id/ENSBTAG00000021199" } ] } } ], "crossref": [ { "id": "A0AAF6Z8W4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8W4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31107:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31107:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10231", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10231", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6B9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6B9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6B9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPRRPAKRLVTALCRAFSGRGCQLAPKRGAERRDAAPSRVSRFCPPRKSRHDWIGPPDKYSNLRPIHFYIPENESPLEQKLRELRQETQEWNQQFWADQNLTFHKEKEEFVRSRLKAKGLDLRTASGQKATLNAEEMAEFYKEFLSKNFQKHMYYNRGNPAVAVHEAVLMRSDCDAKVLFTVSDGAMVVRPWVFKKHLTTHSNTCSQGLVQA", "length": 213, "header": "tr|A0AAF6Z8W4-1|A0AAF6Z8W4_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 8 OS=Bos taurus OX=9913 GN=COA8 PE=3 SV=1 CANONICAL=A0AAF6Z8W4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4/entry", "sequence": { "sequence": "MAPRRPAKRLVTALCRAFSGRGCQLAPKRGAERRDAAPSRVSRFCPPRKSRHDWIGPPDKYSNLRPIHFYIPENESPLEQKLRELRQETQEWNQQFWADQNLTFHKEKEEFVRSRLKAKGLDLRTASGQKATLNAEEMAEFYKEFLSKNFQKHMYYNRGNPAVAVHEAVLMRSDCDAKVLFTVSDGAMVVRPWVFKKHLTTHSNTCSQGLVQA", "length": 213, "header": "tr|A0AAF6Z8W4-1|A0AAF6Z8W4_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 8 OS=Bos taurus OX=9913 GN=COA8 PE=3 SV=1 CANONICAL=A0AAF6Z8W4-1" }, "locus": { "chromosome": "21", "start_pos": 68222499, "end_pos": 68196032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028246.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028246.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028246.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028246.4" } ] } }, { "isoform_ac": "A0ABI0P6B9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6B9/entry", "sequence": { "sequence": "TLPCDARVRRAAMAPRRPAKRLVTALCRAFSGRGCQLAPKRGAERRDAAPSRVSRFCPPRKSRHDWIGPPDKYSNLRPIHFYIPENESPLEQKLRELRQETQEWNQQFWADQNLTFHKEKEEFVRSRLKAKGLDLRTASGQKATLNAEEMAEFYKEFLSKNFQKHMYYNRDWYKRNFAITFFMGKVALERIWNKLRPKQKKTSS", "length": 204, "header": "tr|A0ABI0P6B9-1|A0ABI0P6B9_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 8 OS=Bos taurus OX=9913 GN=COA8 PE=3 SV=1 CANONICAL=A0AAF6Z8W4-1" }, "locus": { "chromosome": "21", "start_pos": 68222587, "end_pos": 68195994, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150217.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150217.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106711.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106711.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ], "pmid": "" }, { "name": "response to reactive oxygen species", "id": "GO:0000302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000302", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway", "id": "GO:0097193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8W4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z8Z7-1", "uniprot_ac": "A0AAF6Z8Z7", "uniprot_id": "A0AAF6Z8Z7_BOVIN", "mass": { "chemical_mass": 22330.0, "monoisotopic_mass": 22330.0 }, "refseq": {}, "gene_names": [ { "name": "CSF3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ] } ], "protein_names": [ { "name": "Granulocyte colony-stimulating factor", "type": "recommended", "evidence": [ { "id": "A0AAF6Z8Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7#function" }, { "database": "UniProtKB", "id": "ARBA00024794", "url": "https://www.uniprot.org/uniprotkb/ARBA00024794#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSF3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7", "locus": { "chromosome": "19", "start_pos": 40332907, "end_pos": 40330599, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021462", "url": "https://www.ensembl.org/id/ENSBTAG00000021462" } ] } } ], "crossref": [ { "id": "A0AAF6Z8Z7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z8Z7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10511", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10511", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10511:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10511:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPSAQSPMKLMVLQLLLWHSALWTVHEATPLGPARSLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQSLQLTSCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLAEP", "length": 204, "header": "tr|A0AAF6Z8Z7-1|A0AAF6Z8Z7_BOVIN Isoform 1 of Granulocyte colony-stimulating factor OS=Bos taurus OX=9913 GN=CSF3 PE=3 SV=2 CANONICAL=A0AAF6Z8Z7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7/entry", "sequence": { "sequence": "MAEPSAQSPMKLMVLQLLLWHSALWTVHEATPLGPARSLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQSLQLTSCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLAEP", "length": 204, "header": "tr|A0AAF6Z8Z7-1|A0AAF6Z8Z7_BOVIN Isoform 1 of Granulocyte colony-stimulating factor OS=Bos taurus OX=9913 GN=CSF3 PE=3 SV=2 CANONICAL=A0AAF6Z8Z7-1" }, "locus": { "chromosome": "19", "start_pos": 40332104, "end_pos": 40330624, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028610.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028610.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028610.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028610.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 163, "start_aa": "Thr", "end_pos": 163, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr163", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "granulocyte colony-stimulating factor signaling pathway", "id": "GO:0038158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038158", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "positive regulation of myeloid cell differentiation", "id": "GO:0045639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045639", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" }, { "name": "granulocyte colony-stimulating factor receptor binding", "id": "GO:0005130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005130", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z8Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Z7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 163 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z967-1", "uniprot_ac": "A0AAF6Z967", "uniprot_id": "A0AAF6Z967_BOVIN", "mass": { "chemical_mass": 11035.0, "monoisotopic_mass": 11035.0 }, "refseq": { "ac": "XP_005202944", "name": "C-C motif chemokine 20 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202944" }, "gene_names": [ { "name": "CCL20", "type": "recommended", "evidence": [ { "id": "A0AAF6Z967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ] }, { "name": "CCL20", "type": "synonym", "evidence": [ { "id": "XP_005202944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202944" } ] } ], "protein_names": [ { "name": "C-C motif chemokine", "type": "recommended", "evidence": [ { "id": "A0AAF6Z967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967/entry#names_and_taxonomy" } ] }, { "name": "C-C motif chemokine 20 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202944" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCL20", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967", "locus": { "chromosome": "2", "start_pos": 115951540, "end_pos": 115948297, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021326", "url": "https://www.ensembl.org/id/ENSBTAG00000021326" } ] } } ], "crossref": [ { "id": "A0AAF6Z967", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z967", "database": "AlphaFoldDB", "categories": [] }, { "id": "281666", "url": "https://www.ncbi.nlm.nih.gov/gene/281666", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015:SF108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015:SF108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005202944", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202944", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z967-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMCSSKNLLLAALMSVLLLHFCSKSEAASNFDCCLRYTERILHPSILVGFTQQLANEACDINAVVFYTRKKLAVCADPKKKWVKQVVHMLSQRVKRM", "length": 97, "header": "tr|A0AAF6Z967-1|A0AAF6Z967_BOVIN Isoform 1 of C-C motif chemokine OS=Bos taurus OX=9913 GN=CCL20 PE=3 SV=1 CANONICAL=A0AAF6Z967-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z967-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967/entry", "sequence": { "sequence": "MMCSSKNLLLAALMSVLLLHFCSKSEAASNFDCCLRYTERILHPSILVGFTQQLANEACDINAVVFYTRKKLAVCADPKKKWVKQVVHMLSQRVKRM", "length": 97, "header": "tr|A0AAF6Z967-1|A0AAF6Z967_BOVIN Isoform 1 of C-C motif chemokine OS=Bos taurus OX=9913 GN=CCL20 PE=3 SV=1 CANONICAL=A0AAF6Z967-1" }, "locus": { "chromosome": "2", "start_pos": 115951495, "end_pos": 115948496, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028430.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028430.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028430.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028430.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "pmid": "" }, { "name": "calcium-mediated signaling", "id": "GO:0019722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "pmid": "" }, { "name": "CCR6 chemokine receptor binding", "id": "GO:0031731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031731", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z967", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z967" }, { "id": "SM00199", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chemokine interleukin-8-like", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 90, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9C3-1", "uniprot_ac": "A0AAF6Z9C3", "uniprot_id": "A0AAF6Z9C3_BOVIN", "mass": { "chemical_mass": 83987.0, "monoisotopic_mass": 83987.0 }, "refseq": {}, "gene_names": [ { "name": "FBXL5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ] } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 5", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3", "locus": { "chromosome": "6", "start_pos": 110760351, "end_pos": 110806130, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021214", "url": "https://www.ensembl.org/id/ENSBTAG00000021214" } ] } } ], "crossref": [ { "id": "A0AAF6Z9C3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9C3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12109", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12109", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22118", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22118", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012312", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012312", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01814", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01814", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAARARPRASSGRAARARAPTGRAHAQGGAPPLPRGEGVYGEAAAAAAEAAAAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTKDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKFFKYSVDEKSDKEAEVSEQSTGITHLPPEVMVSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPAAELDTEPDEEWVKSRRDESRAFQEWDEDADIDESEESGEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTTHESGLLKTSTSKVTSTTWKNKDITMQSFKQSACLHDVTNKDIGEEVDNEHPWTKPISSDDFTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFSCPSSACYSKDIVGLRTSVCWQQHCASPAFAYCGHSYCCTGTALRTMSALPESSALCRKAPRTRLLREKDLIYSGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE", "length": 750, "header": "tr|A0AAF6Z9C3-1|A0AAF6Z9C3_BOVIN Isoform 1 of F-box/LRR-repeat protein 5 OS=Bos taurus OX=9913 GN=FBXL5 PE=4 SV=1 CANONICAL=A0AAF6Z9C3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z9C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3/entry", "sequence": { "sequence": "MAAAARARPRASSGRAARARAPTGRAHAQGGAPPLPRGEGVYGEAAAAAAEAAAAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTKDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKFFKYSVDEKSDKEAEVSEQSTGITHLPPEVMVSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPAAELDTEPDEEWVKSRRDESRAFQEWDEDADIDESEESGEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTTHESGLLKTSTSKVTSTTWKNKDITMQSFKQSACLHDVTNKDIGEEVDNEHPWTKPISSDDFTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFSCPSSACYSKDIVGLRTSVCWQQHCASPAFAYCGHSYCCTGTALRTMSALPESSALCRKAPRTRLLREKDLIYSGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE", "length": 750, "header": "tr|A0AAF6Z9C3-1|A0AAF6Z9C3_BOVIN Isoform 1 of F-box/LRR-repeat protein 5 OS=Bos taurus OX=9913 GN=FBXL5 PE=4 SV=1 CANONICAL=A0AAF6Z9C3-1" }, "locus": { "chromosome": "6", "start_pos": 110805931, "end_pos": 110761070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028266.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028266.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028266.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028266.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" }, { "name": "iron-sulfur cluster binding", "id": "GO:0051536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051536", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular iron ion homeostasis", "id": "GO:0006879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z9C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9C3" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 261, "end_pos": 307, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 571, "end_pos": 573 }, { "start_pos": 691, "end_pos": 693 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9I0-1", "uniprot_ac": "A0AAF6Z9I0", "uniprot_id": "A0AAF6Z9I0_BOVIN", "mass": { "chemical_mass": 20453.0, "monoisotopic_mass": 20453.0 }, "refseq": { "ac": "XP_024842876", "name": "transmembrane protein 138 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842876" }, "gene_names": [ { "name": "TMEM138", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0" } ] }, { "name": "TMEM138", "type": "synonym", "evidence": [ { "id": "XP_024842876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842876" } ] } ], "protein_names": [ { "name": "Transmembrane protein 138", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 138 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024842876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842876" } ] } ], "function": [ { "annotation": "Required for ciliogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9I0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0#function" }, { "database": "UniProtKB", "id": "ARBA00003709", "url": "https://www.uniprot.org/uniprotkb/ARBA00003709#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9I0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM138", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0", "locus": { "chromosome": "29", "start_pos": 39888005, "end_pos": 39867808, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021604", "url": "https://www.ensembl.org/id/ENSBTAG00000021604" } ] } } ], "crossref": [ { "id": "A0AAF6Z9I0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9I0", "database": "AlphaFoldDB", "categories": [] }, { "id": "514277", "url": "https://www.ncbi.nlm.nih.gov/gene/514277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13306:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13306:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14935", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14935", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842876", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842876", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9I0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQTSNYSLVLSLQFLLLSYDLFVNSFSELLRMAPVIQLVLFIIQDIAILFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNCFVWTDGLQTLFVFQRLAAVLYCYFYKRTAVRLGDPRFYQDSLWLRMEFMQVRSGCTGAGGPRGAIPR", "length": 176, "header": "tr|A0AAF6Z9I0-1|A0AAF6Z9I0_BOVIN Isoform 1 of Transmembrane protein 138 OS=Bos taurus OX=9913 GN=TMEM138 PE=3 SV=1 CANONICAL=A0AAF6Z9I0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z9I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0/entry", "sequence": { "sequence": "MLQTSNYSLVLSLQFLLLSYDLFVNSFSELLRMAPVIQLVLFIIQDIAILFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNCFVWTDGLQTLFVFQRLAAVLYCYFYKRTAVRLGDPRFYQDSLWLRMEFMQVRSGCTGAGGPRGAIPR", "length": 176, "header": "tr|A0AAF6Z9I0-1|A0AAF6Z9I0_BOVIN Isoform 1 of Transmembrane protein 138 OS=Bos taurus OX=9913 GN=TMEM138 PE=3 SV=1 CANONICAL=A0AAF6Z9I0-1" }, "locus": { "chromosome": "29", "start_pos": 39887095, "end_pos": 39869937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028789.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028789.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028789.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028789.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9I0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0" } ], "pmid": "" }, { "name": "vacuolar membrane", "id": "GO:0005774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005774", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9I0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9I0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9I0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9T9-1", "uniprot_ac": "A0AAF6Z9T9", "uniprot_id": "A0AAF6Z9T9_BOVIN", "mass": { "chemical_mass": 39663.0, "monoisotopic_mass": 39663.0 }, "refseq": {}, "gene_names": [ { "name": "FSTL3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ] } ], "protein_names": [ { "name": "Follistatin-related protein 3", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9/entry#names_and_taxonomy" } ] }, { "name": "Follistatin-like protein 3", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FSTL3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9", "locus": { "chromosome": "7", "start_pos": 43285838, "end_pos": 43279201, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003018", "url": "https://www.ensembl.org/id/ENSBTAG00000003018" } ] } } ], "crossref": [ { "id": "A0AAF6Z9T9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09289", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09289", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21333", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21333", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTTMRKAQQTHSSWVTGQLVSQTHGDTSNSKPRARLPGGAPAPHQLPPTSRATLPRAPPSPRPAPAGPPRPARSPRDLYRARRPRAGSGAAAALSAARPPAARASDAGVAAVSAFAMRPRAPGPLWPLPWGALAWAVGFVGSLGSGDPAPGGVCWLQQGREATCSLVLKTDVSQAECCASGNIDTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCEGVECGPGKACRMLGGRPRCECAPDCTGLPARLQVCGSDGATYRDECELRAARCRGHPDLRVMYRGRCRKSCAHVVCLRPQSCVVDQTGSAHCVVCRAAPCPAPSSPGQELCGNNNVTYLSSCHLRQATCFLGRSIGVRHPGSCAGTPEPLDPESEEEENFV", "length": 378, "header": "tr|A0AAF6Z9T9-1|A0AAF6Z9T9_BOVIN Isoform 1 of Follistatin-related protein 3 OS=Bos taurus OX=9913 GN=FSTL3 PE=4 SV=1 CANONICAL=A0AAF6Z9T9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z9T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9/entry", "sequence": { "sequence": "MQTTMRKAQQTHSSWVTGQLVSQTHGDTSNSKPRARLPGGAPAPHQLPPTSRATLPRAPPSPRPAPAGPPRPARSPRDLYRARRPRAGSGAAAALSAARPPAARASDAGVAAVSAFAMRPRAPGPLWPLPWGALAWAVGFVGSLGSGDPAPGGVCWLQQGREATCSLVLKTDVSQAECCASGNIDTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCEGVECGPGKACRMLGGRPRCECAPDCTGLPARLQVCGSDGATYRDECELRAARCRGHPDLRVMYRGRCRKSCAHVVCLRPQSCVVDQTGSAHCVVCRAAPCPAPSSPGQELCGNNNVTYLSSCHLRQATCFLGRSIGVRHPGSCAGTPEPLDPESEEEENFV", "length": 378, "header": "tr|A0AAF6Z9T9-1|A0AAF6Z9T9_BOVIN Isoform 1 of Follistatin-related protein 3 OS=Bos taurus OX=9913 GN=FSTL3 PE=4 SV=1 CANONICAL=A0AAF6Z9T9-1" }, "locus": { "chromosome": "7", "start_pos": 43284741, "end_pos": 43279218, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028801.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028801.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028801.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028801.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of cell-cell adhesion", "id": "GO:0022409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022409", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "negative regulation of activin receptor signaling pathway", "id": "GO:0032926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032926", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "negative regulation of osteoclast differentiation", "id": "GO:0045671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045671", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "activin binding", "id": "GO:0048185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048185", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" }, { "name": "fibronectin binding", "id": "GO:0001968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001968", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 286, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6Z9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9T9" }, { "id": "PS51364", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51364" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TB", "eco_id": "ECO_0000259", "start_pos": 153, "end_pos": 212, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 332, "end_pos": 334 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9U4-1", "uniprot_ac": "A0AAF6Z9U4", "uniprot_id": "A0AAF6Z9U4_BOVIN", "mass": { "chemical_mass": 34820.0, "monoisotopic_mass": 34820.0 }, "refseq": {}, "gene_names": [ { "name": "CLDN5", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4" } ] } ], "protein_names": [ { "name": "Claudin 5", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9U4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLDN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4", "locus": { "chromosome": "17", "start_pos": 72734245, "end_pos": 72736405, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022020", "url": "https://www.ensembl.org/id/ENSBTAG00000022020" } ] } } ], "crossref": [ { "id": "A0AAF6Z9U4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9U4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z9U4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSAETRTAVPPAPAAHYPATRLPWAQLFLLLRLPAVPAIGCGQMAARGLAARGRGRAGRGAESAPEPSKGKPLQTRPQTRGCTAVPRGLETERVSRARPEAPGRRARVSPPAMGSAALEILGLVLCLVGWVGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSPEVQAARALTVGAVLLALVALFVTLAGAQCTTCVAPGPAKARVALTGGALYALCGLLALVPLCWFANIVVREFYDPTVPMSQKYELGAALYIGWAASALLMCGGGLVCCGAWVCTGRPDFSFPVKYSASRRPTATGDYDKKNYV", "length": 331, "header": "tr|A0AAF6Z9U4-1|A0AAF6Z9U4_BOVIN Isoform 1 of Claudin 5 OS=Bos taurus OX=9913 GN=CLDN5 PE=3 SV=1 CANONICAL=A0AAF6Z9U4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z9U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4/entry", "sequence": { "sequence": "MGSAETRTAVPPAPAAHYPATRLPWAQLFLLLRLPAVPAIGCGQMAARGLAARGRGRAGRGAESAPEPSKGKPLQTRPQTRGCTAVPRGLETERVSRARPEAPGRRARVSPPAMGSAALEILGLVLCLVGWVGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSPEVQAARALTVGAVLLALVALFVTLAGAQCTTCVAPGPAKARVALTGGALYALCGLLALVPLCWFANIVVREFYDPTVPMSQKYELGAALYIGWAASALLMCGGGLVCCGAWVCTGRPDFSFPVKYSASRRPTATGDYDKKNYV", "length": 331, "header": "tr|A0AAF6Z9U4-1|A0AAF6Z9U4_BOVIN Isoform 1 of Claudin 5 OS=Bos taurus OX=9913 GN=CLDN5 PE=3 SV=1 CANONICAL=A0AAF6Z9U4-1" }, "locus": { "chromosome": "17", "start_pos": 72736078, "end_pos": 72735086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029418.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029418.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029418.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029418.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9U4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9U4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9U4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9U4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9Y0-1", "uniprot_ac": "A0AAF6Z9Y0", "uniprot_id": "A0AAF6Z9Y0_BOVIN", "mass": { "chemical_mass": 17110.0, "monoisotopic_mass": 17110.0 }, "refseq": {}, "gene_names": [ { "name": "RNASEK", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0" } ] } ], "protein_names": [ { "name": "Ribonuclease K", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNASEK", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0", "locus": { "chromosome": "19", "start_pos": 26804385, "end_pos": 26802415, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021932", "url": "https://www.ensembl.org/id/ENSBTAG00000021932" } ] } } ], "crossref": [ { "id": "A0AAF6Z9Y0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9Y0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056552", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056552", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31733", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31733", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23489", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23489", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEPGGHAPRSHSQLYVLRSSSPQVQLFFQLLRPSSHRFPTWPISRPSLTPFFMASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYNLYEQVSYNCFIAASLYLLLGGFSFCQVRLNKRKEYMVR", "length": 151, "header": "tr|A0AAF6Z9Y0-1|A0AAF6Z9Y0_BOVIN Isoform 1 of Ribonuclease K OS=Bos taurus OX=9913 GN=RNASEK PE=3 SV=1 CANONICAL=A0AAF6Z9Y0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z9Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0/entry", "sequence": { "sequence": "MVEPGGHAPRSHSQLYVLRSSSPQVQLFFQLLRPSSHRFPTWPISRPSLTPFFMASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYNLYEQVSYNCFIAASLYLLLGGFSFCQVRLNKRKEYMVR", "length": 151, "header": "tr|A0AAF6Z9Y0-1|A0AAF6Z9Y0_BOVIN Isoform 1 of Ribonuclease K OS=Bos taurus OX=9913 GN=RNASEK PE=3 SV=1 CANONICAL=A0AAF6Z9Y0-1" }, "locus": { "chromosome": "19", "start_pos": 26804138, "end_pos": 26802614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029239.4", "url": "https://www.ensembl.org/id/ENSBTAT00000029239.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029239.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029239.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Y0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z9Z6-1", "uniprot_ac": "A0AAF6Z9Z6", "uniprot_id": "A0AAF6Z9Z6_BOVIN", "mass": { "chemical_mass": 20418.0, "monoisotopic_mass": 20418.0 }, "refseq": { "ac": "XP_005211977", "name": "NPC intracellular cholesterol transporter 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211977" }, "gene_names": [ { "name": "NPC2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ] }, { "name": "HE1", "type": "synonym", "evidence": [ { "id": "XP_005211977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211977" } ] }, { "name": "NPC2", "type": "synonym", "evidence": [ { "id": "XP_005211977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211977" } ] } ], "protein_names": [ { "name": "NPC intracellular cholesterol transporter 2", "type": "recommended", "evidence": [ { "id": "A0AAF6Z9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6/entry#names_and_taxonomy" } ] }, { "name": "Epididymal secretory protein E1", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6/entry#names_and_taxonomy" } ] }, { "name": "NPC intracellular cholesterol transporter 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005211977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211977" } ] }, { "name": "Niemann Pick type C2 protein homolog", "type": "synonym", "evidence": [ { "id": "A0AAF6Z9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6#function" }, { "database": "UniProtKB", "id": "ARBA00045538", "url": "https://www.uniprot.org/uniprotkb/ARBA00045538#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPC2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6", "locus": { "chromosome": "10", "start_pos": 85774963, "end_pos": 85783571, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021955", "url": "https://www.ensembl.org/id/ENSBTAG00000021955" } ] } } ], "crossref": [ { "id": "A0AAF6Z9Z6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z9Z6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00916", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00916", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "280815", "url": "https://www.ncbi.nlm.nih.gov/gene/280815", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11306:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11306:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211977", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "39747", "url": "https://www.rhea-db.org/rhea/39747", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRLLGWVWRVLRAARLSLGPFVEWAGVAWGRGQGAGLDKTRPLTTLSHQPMFWSQHIPGGSWVGVIKEVNVSPCPTQPCKLHRGQSYSVNVTFTSNTQSQSSKAVVHGIVMGIPVPFPIPESDGCKSGIRCPIEKDKTYNYVNKLPVKNEYPSIKVVVEWELTDDKNQRFFCWQIPIEVEA", "length": 182, "header": "tr|A0AAF6Z9Z6-1|A0AAF6Z9Z6_BOVIN Isoform 1 of NPC intracellular cholesterol transporter 2 OS=Bos taurus OX=9913 GN=NPC2 PE=3 SV=1 CANONICAL=A0AAF6Z9Z6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z9Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6/entry", "sequence": { "sequence": "MLRLLGWVWRVLRAARLSLGPFVEWAGVAWGRGQGAGLDKTRPLTTLSHQPMFWSQHIPGGSWVGVIKEVNVSPCPTQPCKLHRGQSYSVNVTFTSNTQSQSSKAVVHGIVMGIPVPFPIPESDGCKSGIRCPIEKDKTYNYVNKLPVKNEYPSIKVVVEWELTDDKNQRFFCWQIPIEVEA", "length": 182, "header": "tr|A0AAF6Z9Z6-1|A0AAF6Z9Z6_BOVIN Isoform 1 of NPC intracellular cholesterol transporter 2 OS=Bos taurus OX=9913 GN=NPC2 PE=3 SV=1 CANONICAL=A0AAF6Z9Z6-1" }, "locus": { "chromosome": "10", "start_pos": 85783372, "end_pos": 85775734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029271.4", "url": "https://www.ensembl.org/id/ENSBTAT00000029271.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029271.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029271.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 77, "start_aa": "Thr", "end_pos": 77, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "lysosomal lumen", "id": "GO:0043202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "cholesterol transfer activity", "id": "GO:0120020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "cholesterol efflux", "id": "GO:0033344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033344", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" }, { "name": "lysosome to ER cholesterol transport", "id": "GO:0090120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090120", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z9Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39747", "name": "", "equation": "cholesterol(in) = cholesterol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "39747", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39747" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6Z9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9Z6" }, { "id": "SM00737", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00737" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MD-2-related lipid-recognition", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 178, "start_aa": "Trp", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 77 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZAD2-1", "uniprot_ac": "A0AAF6ZAD2", "uniprot_id": "A0AAF6ZAD2_BOVIN", "mass": { "chemical_mass": 55990.0, "monoisotopic_mass": 55990.0 }, "refseq": {}, "gene_names": [ { "name": "IQCD", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2" } ] } ], "protein_names": [ { "name": "Dynein regulatory complex subunit 10", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2/entry#names_and_taxonomy" } ] }, { "name": "IQ domain-containing protein D", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2#function" }, { "database": "UniProtKB", "id": "ARBA00003029", "url": "https://www.uniprot.org/uniprotkb/ARBA00003029#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IQCD", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2", "locus": { "chromosome": "17", "start_pos": 61199806, "end_pos": 61225586, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001806", "url": "https://www.ensembl.org/id/ENSBTAG00000001806" } ] } } ], "crossref": [ { "id": "A0AAF6ZAD2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZAD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31598", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31598", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31598:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31598:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZAD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALDVLTVAPLYQGPDINKIRLIAQTTKKSTIPPKALTPARSKLTTIETKRIMSVLDETIHKVELVSLLSHAASESKTSEGMLGPDIAKAVREHEDLCQALLDRVSYLQEEERKLQEAEDFEDEAWFRERLFAMDLQKSQLPPLMQEIKESTKNVVRLLLSNPQAASLLQAQTLGRSKEAQCFIDSLVELRGFLFEKLLTSPMEARDKIQFIQDITRRNRRHQEIIDTLENELAACVRNRNAEVEKENFVIQELKNHLHQVLRFSENSLLRTKQEAEKQQKADFRASQARVATVQQEILVLQSQFYNLVMENRDTEQALRKKKYKVETEIENWIQKYDSEMSEKQDEYEELDIIHKEEQLQLEELKKRHDVLVEEFSQIQAEREILTKKRLEDEQEMVRMVRAATLIQALWKGYLVRSMLKSKKKKRGKGKGEKKGKGKGKGKKFVMEKAMAPHSSTLAWKIPWTEEPGGLQSMGFRRVRHD", "length": 482, "header": "tr|A0AAF6ZAD2-1|A0AAF6ZAD2_BOVIN Isoform 1 of Dynein regulatory complex subunit 10 OS=Bos taurus OX=9913 GN=IQCD PE=3 SV=1 CANONICAL=A0AAF6ZAD2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZAD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2/entry", "sequence": { "sequence": "MALDVLTVAPLYQGPDINKIRLIAQTTKKSTIPPKALTPARSKLTTIETKRIMSVLDETIHKVELVSLLSHAASESKTSEGMLGPDIAKAVREHEDLCQALLDRVSYLQEEERKLQEAEDFEDEAWFRERLFAMDLQKSQLPPLMQEIKESTKNVVRLLLSNPQAASLLQAQTLGRSKEAQCFIDSLVELRGFLFEKLLTSPMEARDKIQFIQDITRRNRRHQEIIDTLENELAACVRNRNAEVEKENFVIQELKNHLHQVLRFSENSLLRTKQEAEKQQKADFRASQARVATVQQEILVLQSQFYNLVMENRDTEQALRKKKYKVETEIENWIQKYDSEMSEKQDEYEELDIIHKEEQLQLEELKKRHDVLVEEFSQIQAEREILTKKRLEDEQEMVRMVRAATLIQALWKGYLVRSMLKSKKKKRGKGKGEKKGKGKGKGKKFVMEKAMAPHSSTLAWKIPWTEEPGGLQSMGFRRVRHD", "length": 482, "header": "tr|A0AAF6ZAD2-1|A0AAF6ZAD2_BOVIN Isoform 1 of Dynein regulatory complex subunit 10 OS=Bos taurus OX=9913 GN=IQCD PE=3 SV=1 CANONICAL=A0AAF6ZAD2-1" }, "locus": { "chromosome": "17", "start_pos": 61212168, "end_pos": 61200810, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029527.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029527.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029526.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029526.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZAD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAD2" }, { "id": "PF27661", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27661" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DRC9/10 N-terminal", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 202, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZAM5-1", "uniprot_ac": "A0AAF6ZAM5", "uniprot_id": "A0AAF6ZAM5_BOVIN", "mass": { "chemical_mass": 28999.0, "monoisotopic_mass": 28999.0 }, "refseq": {}, "gene_names": [ { "name": "LENG1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5" } ] } ], "protein_names": [ { "name": "Leukocyte receptor cluster member 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LENG1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5", "locus": { "chromosome": "18", "start_pos": 63249596, "end_pos": 63238454, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023333", "url": "https://www.ensembl.org/id/ENSBTAG00000023333" } ] } } ], "crossref": [ { "id": "A0AAF6ZAM5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZAM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22093", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22093", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22093:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22093:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10197", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10197", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZAM5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEARAREEEKERERRVLLAQQEARTEFLRKKARHQNWLPALEAAEAGAPGSSGPVDLFRELLEEGKAVTKGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPRQGGPASGPGPDERIKSRLDPLREMQKHLGKKRKHSGDSGGHSTKEKAAPEKQRPKGPPSLEQLRADRLRREAAERARAEALLARVGGTAAPEEQPEEVDERRRRPTPRSRMSSRSRSS", "length": 255, "header": "tr|A0AAF6ZAM5-1|A0AAF6ZAM5_BOVIN Isoform 1 of Leukocyte receptor cluster member 1 OS=Bos taurus OX=9913 GN=LENG1 PE=4 SV=1 CANONICAL=A0AAF6ZAM5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZAM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5/entry", "sequence": { "sequence": "MNILPKKSWHVRNKDNVARVRRDEARAREEEKERERRVLLAQQEARTEFLRKKARHQNWLPALEAAEAGAPGSSGPVDLFRELLEEGKAVTKGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPRQGGPASGPGPDERIKSRLDPLREMQKHLGKKRKHSGDSGGHSTKEKAAPEKQRPKGPPSLEQLRADRLRREAAERARAEALLARVGGTAAPEEQPEEVDERRRRPTPRSRMSSRSRSS", "length": 255, "header": "tr|A0AAF6ZAM5-1|A0AAF6ZAM5_BOVIN Isoform 1 of Leukocyte receptor cluster member 1 OS=Bos taurus OX=9913 GN=LENG1 PE=4 SV=1 CANONICAL=A0AAF6ZAM5-1" }, "locus": { "chromosome": "18", "start_pos": 63249453, "end_pos": 63238480, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031738.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031738.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031685.5", "url": "https://www.ensembl.org/id/ENSBTAP00000031685.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAM5" }, { "id": "SM01083", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01083" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBF1-interacting co-repressor CIR N-terminal", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 44, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZAU7-1", "uniprot_ac": "A0AAF6ZAU7", "uniprot_id": "A0AAF6ZAU7_BOVIN", "mass": { "chemical_mass": 14537.0, "monoisotopic_mass": 14537.0 }, "refseq": {}, "gene_names": [ { "name": "TCTA", "type": "recommended", "evidence": [ { "id": "A0AAF6ZAU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7" } ] } ], "protein_names": [ { "name": "T cell leukemia translocation altered", "type": "synonym", "evidence": [ { "id": "A0AAF6ZAU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be required for cellular fusion during osteoclastogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7#function" }, { "database": "UniProtKB", "id": "ARBA00003045", "url": "https://www.uniprot.org/uniprotkb/ARBA00003045#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCTA", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7", "locus": { "chromosome": "22", "start_pos": 50697897, "end_pos": 50700975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022632", "url": "https://www.ensembl.org/id/ENSBTAG00000022632" } ] } } ], "crossref": [ { "id": "A0AAF6ZAU7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZAU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR016560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR32267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32267:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32267:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15128", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15128", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZAU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPWSGQSLQALPATVLGALGALGSEFLREWEAQDMRVTLFKLLLFWLVLSLLSIQLAWGFYGSTVTGLYHRPVPLTWADNCSDTHRQPVAFLDVFLPPGLGGQNGSTPDGSTHFPSWETAANEPLKTHRE", "length": 132, "header": "tr|A0AAF6ZAU7-1|A0AAF6ZAU7_BOVIN Isoform 1 of T cell leukemia translocation altered OS=Bos taurus OX=9913 GN=TCTA PE=3 SV=1 CANONICAL=A0AAF6ZAU7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZAU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7/entry", "sequence": { "sequence": "MAEPWSGQSLQALPATVLGALGALGSEFLREWEAQDMRVTLFKLLLFWLVLSLLSIQLAWGFYGSTVTGLYHRPVPLTWADNCSDTHRQPVAFLDVFLPPGLGGQNGSTPDGSTHFPSWETAANEPLKTHRE", "length": 132, "header": "tr|A0AAF6ZAU7-1|A0AAF6ZAU7_BOVIN Isoform 1 of T cell leukemia translocation altered OS=Bos taurus OX=9913 GN=TCTA PE=3 SV=1 CANONICAL=A0AAF6ZAU7-1" }, "locus": { "chromosome": "22", "start_pos": 50700776, "end_pos": 50699139, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030664.4", "url": "https://www.ensembl.org/id/ENSBTAT00000030664.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030636.3", "url": "https://www.ensembl.org/id/ENSBTAP00000030636.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of osteoclast differentiation", "id": "GO:0045671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045671", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7" } ], "pmid": "" }, { "name": "osteoclast fusion", "id": "GO:0072675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072675", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZAU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZBB9-1", "uniprot_ac": "A0AAF6ZBB9", "uniprot_id": "A0AAF6ZBB9_BOVIN", "mass": { "chemical_mass": 15507.0, "monoisotopic_mass": 15507.0 }, "refseq": { "ac": "XP_010802022", "name": "cilia- and flagella-associated protein 144 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802022" }, "gene_names": [ { "name": "CFAP144", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9" } ] }, { "name": "CFAP144", "type": "synonym", "evidence": [ { "id": "XP_010802022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802022" } ] }, { "name": "FAM183A", "type": "synonym", "evidence": [ { "id": "XP_010802022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802022" } ] } ], "protein_names": [ { "name": "Cilia and flagella associated protein 144", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9/entry#names_and_taxonomy" } ] }, { "name": "cilia- and flagella-associated protein 144 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010802022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802022" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBB9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP144", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZBB9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZBB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "782130", "url": "https://www.ncbi.nlm.nih.gov/gene/782130", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33865", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33865", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33865:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33865:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010802022", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802022", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBB9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGHQKEKAIADEVHQNQILRELYLKELRTQKLYTQYHVNPLRKVHTIARKPMSWHDNLEEPADARFLNLIHHAAQGPRKKYPETQTEGQEIGWDSEPLGLARKSTRGHTSGDWDLSQVQVPTRQGLPPSPQASF", "length": 135, "header": "tr|A0AAF6ZBB9-1|A0AAF6ZBB9_BOVIN Isoform 1 of Cilia and flagella associated protein 144 OS=Bos taurus OX=9913 GN=CFAP144 PE=3 SV=1 CANONICAL=A0AAF6ZBB9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZBB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9/entry", "sequence": { "sequence": "MAGHQKEKAIADEVHQNQILRELYLKELRTQKLYTQYHVNPLRKVHTIARKPMSWHDNLEEPADARFLNLIHHAAQGPRKKYPETQTEGQEIGWDSEPLGLARKSTRGHTSGDWDLSQVQVPTRQGLPPSPQASF", "length": 135, "header": "tr|A0AAF6ZBB9-1|A0AAF6ZBB9_BOVIN Isoform 1 of Cilia and flagella associated protein 144 OS=Bos taurus OX=9913 GN=CFAP144 PE=3 SV=1 CANONICAL=A0AAF6ZBB9-1" }, "locus": { "chromosome": "3", "start_pos": 102860315, "end_pos": 102852142, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033276.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033276.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033194.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033194.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBB9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBB9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZBD7-1", "uniprot_ac": "A0AAF6ZBD7", "uniprot_id": "A0AAF6ZBD7_BOVIN", "mass": { "chemical_mass": 27380.0, "monoisotopic_mass": 27380.0 }, "refseq": { "ac": "XP_005212640", "name": "serine/arginine-rich splicing factor 7 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212640" }, "gene_names": [ { "name": "SRSF7", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ] }, { "name": "SFRS7", "type": "synonym", "evidence": [ { "id": "XP_005212640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212640" } ] }, { "name": "SRSF7", "type": "synonym", "evidence": [ { "id": "XP_005212640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212640" } ] } ], "protein_names": [ { "name": "Serine/arginine-rich splicing factor 7", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7/entry#names_and_taxonomy" } ] }, { "name": "Splicing factor, arginine/serine-rich 7", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7/entry#names_and_taxonomy" } ] }, { "name": "serine/arginine-rich splicing factor 7 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212640" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRSF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7", "locus": { "chromosome": "11", "start_pos": 21086083, "end_pos": 21091537, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014891", "url": "https://www.ensembl.org/id/ENSBTAG00000014891" } ] } } ], "crossref": [ { "id": "A0AAF6ZBD7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZBD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12646", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12646", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507066", "url": "https://www.ncbi.nlm.nih.gov/gene/507066", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48038:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48038:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212640", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212640", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSVSLRRSRSASLRRSRSGSIKGSRYFQSRSRSRSRSRSLSRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERVD", "length": 238, "header": "tr|A0AAF6ZBD7-1|A0AAF6ZBD7_BOVIN Isoform 1 of Serine/arginine-rich splicing factor 7 OS=Bos taurus OX=9913 GN=SRSF7 PE=3 SV=1 CANONICAL=A0AAF6ZBD7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZBD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7/entry", "sequence": { "sequence": "MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSVSLRRSRSASLRRSRSGSIKGSRYFQSRSRSRSRSRSLSRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERVD", "length": 238, "header": "tr|A0AAF6ZBD7-1|A0AAF6ZBD7_BOVIN Isoform 1 of Serine/arginine-rich splicing factor 7 OS=Bos taurus OX=9913 GN=SRSF7 PE=3 SV=1 CANONICAL=A0AAF6ZBD7-1" }, "locus": { "chromosome": "11", "start_pos": 21091431, "end_pos": 21086328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033124.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033124.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033048.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033048.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" }, { "name": "negative regulation of mRNA splicing, via spliceosome", "id": "GO:0048025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048025", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" }, { "id": "PS50158", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC-type", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 119, "start_aa": "Arg", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBD7" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 84, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZBG6-1", "uniprot_ac": "A0AAF6ZBG6", "uniprot_id": "A0AAF6ZBG6_BOVIN", "mass": { "chemical_mass": 35056.0, "monoisotopic_mass": 35056.0 }, "refseq": {}, "gene_names": [ { "name": "SOD1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ] } ], "protein_names": [ { "name": "Superoxide dismutase [Cu-Zn]", "type": "recommended", "evidence": [ { "id": "A0AAF6ZBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6/entry#names_and_taxonomy" } ] }, { "name": "1.15.1.1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6#function" }, { "database": "UniProtKB", "id": "RU000393", "url": "https://www.uniprot.org/uniprotkb/RU000393#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SOD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZBG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZBG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00305", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00305", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00080", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00080", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "20696", "url": "https://www.rhea-db.org/rhea/20696", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85007", "url": "https://www.rhea-db.org/rhea/85007", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZBG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVSTCETQKRQRQDQSQLSLINICGQRDFISSRRATYIPPCPTFVYCNPQITPFRGESLGGGCFFFPPRIQVLLRVFTQPQGGEGRRRLSDGLPTPPLGSAPPSGPPRGHPVAGERAESAGGDWLRARLGGARPSSPIKVRRRASLGFASACVLRRRFLYLVGASLAVRAGEPFPRVMATKAVCVLKGDGPVQGTIHFEAKGDTVVVTGSITGLTEGDHGFHVHQFGDNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTADKNGVAIVDIVDPLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGSRLACGVIGIAK", "length": 330, "header": "tr|A0AAF6ZBG6-1|A0AAF6ZBG6_BOVIN Isoform 1 of Superoxide dismutase [Cu-Zn] OS=Bos taurus OX=9913 GN=SOD1 PE=3 SV=1 CANONICAL=A0AAF6ZBG6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZBG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6/entry", "sequence": { "sequence": "MSVSTCETQKRQRQDQSQLSLINICGQRDFISSRRATYIPPCPTFVYCNPQITPFRGESLGGGCFFFPPRIQVLLRVFTQPQGGEGRRRLSDGLPTPPLGSAPPSGPPRGHPVAGERAESAGGDWLRARLGGARPSSPIKVRRRASLGFASACVLRRRFLYLVGASLAVRAGEPFPRVMATKAVCVLKGDGPVQGTIHFEAKGDTVVVTGSITGLTEGDHGFHVHQFGDNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTADKNGVAIVDIVDPLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGSRLACGVIGIAK", "length": 330, "header": "tr|A0AAF6ZBG6-1|A0AAF6ZBG6_BOVIN Isoform 1 of Superoxide dismutase [Cu-Zn] OS=Bos taurus OX=9913 GN=SOD1 PE=3 SV=1 CANONICAL=A0AAF6ZBG6-1" }, "locus": { "chromosome": "1", "start_pos": 3833735, "end_pos": 3824934, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032452.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032452.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032384.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032384.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ], "pmid": "" }, { "name": "superoxide dismutase activity", "id": "GO:0004784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004784", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20696", "name": "", "equation": "2 superoxide + 2 H(+) = H2O2 + O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BHL1-1", "A0AAF6ZBG6-1", "P00442-1", "E1BMU2-1", "P41976-1", "F1MNQ4-1", "E1BE86-1" ], "evidence": [ { "id": "20696", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20696" } ] }, { "id": "85007", "name": "", "equation": "hydrogen sulfide + 2 O2 = sulfate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00442-1", "E1BE86-1", "A0AAF6ZBG6-1", "F1MNQ4-1" ], "evidence": [ { "id": "85007", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85007" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZBG6", "gene_name": "SOD1", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "A0AAF6ZBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "A0AAF6ZBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" } ] } ] }, { "uniprot_ac": "E1BE86", "gene_name": "CCS", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "E1BE86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE86" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "E1BE86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE86" } ] } ] }, { "uniprot_ac": "E1BHL1", "gene_name": "SOD2", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "E1BHL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHL1" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "E1BHL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHL1" } ] } ] }, { "uniprot_ac": "E1BMU2", "gene_name": "CYGB", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "E1BMU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMU2" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "E1BMU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMU2" } ] } ] }, { "uniprot_ac": "F1MNQ4", "gene_name": "", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "F1MNQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNQ4" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "F1MNQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNQ4" } ] } ] }, { "uniprot_ac": "P00442", "gene_name": "SOD1", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P00442", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00442" } ] }, { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "P00442", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00442" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "P00442", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00442" } ] } ] }, { "uniprot_ac": "P41976", "gene_name": "SOD2", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "P41976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41976" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "P41976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P41976" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZBG6" }, { "id": "PF00080", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Superoxide dismutase copper/zinc binding", "eco_id": "ECO_0000259", "start_pos": 193, "end_pos": 326, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.15.1.1", "ec_name": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "1.15.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1" }, { "id": "1.15.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.15.1.1" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 263, "end_pos": 265 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCA1-1", "uniprot_ac": "A0AAF6ZCA1", "uniprot_id": "A0AAF6ZCA1_BOVIN", "mass": { "chemical_mass": 55144.0, "monoisotopic_mass": 55144.0 }, "refseq": {}, "gene_names": [ { "name": "FSCN2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ] } ], "protein_names": [ { "name": "Fascin", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FSCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1", "locus": { "chromosome": "19", "start_pos": 51236231, "end_pos": 51242016, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024932", "url": "https://www.ensembl.org/id/ENSBTAG00000024932" } ] } } ], "crossref": [ { "id": "A0AAF6ZCA1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23345", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23345", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23349", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23349", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR008999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10551:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10551:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQMWVLEPDPGEGTAVLFRSSHLGRYLSAEEDGRVACEAERPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGTEDQLSCFATAITPAELWTVHLAIHPQAHLLSVSRRRYAHLCPQEDEIAADSNTPWGVDALVTLIFQNRQYCLKSCDSRYLRSDGRLVWEPEARARYTLEFKAGKLAFKDCDGHYLAPVGPAGTLRAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDEELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSENTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVAGEDEEFTLKLINRPILVLRGLDGFVCHRRGSNQLDTNRSVYDVFHLSFSDGAYQIRGRGGGFWHTGSHGSVCSDGERAEDFLFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGVALWEY", "length": 493, "header": "tr|A0AAF6ZCA1-1|A0AAF6ZCA1_BOVIN Isoform 1 of Fascin OS=Bos taurus OX=9913 GN=FSCN2 PE=3 SV=1 CANONICAL=A0AAF6ZCA1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZCA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1/entry", "sequence": { "sequence": "MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQMWVLEPDPGEGTAVLFRSSHLGRYLSAEEDGRVACEAERPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGTEDQLSCFATAITPAELWTVHLAIHPQAHLLSVSRRRYAHLCPQEDEIAADSNTPWGVDALVTLIFQNRQYCLKSCDSRYLRSDGRLVWEPEARARYTLEFKAGKLAFKDCDGHYLAPVGPAGTLRAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDEELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSENTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVAGEDEEFTLKLINRPILVLRGLDGFVCHRRGSNQLDTNRSVYDVFHLSFSDGAYQIRGRGGGFWHTGSHGSVCSDGERAEDFLFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGVALWEY", "length": 493, "header": "tr|A0AAF6ZCA1-1|A0AAF6ZCA1_BOVIN Isoform 1 of Fascin OS=Bos taurus OX=9913 GN=FSCN2 PE=3 SV=1 CANONICAL=A0AAF6ZCA1-1" }, "locus": { "chromosome": "19", "start_pos": 51241982, "end_pos": 51236271, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034735.5", "url": "https://www.ensembl.org/id/ENSBTAT00000034735.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034620.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034620.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 126, "start_aa": "Thr", "end_pos": 126, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr126", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCA1" }, { "id": "PF06268", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fascin-like", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 133, "start_aa": "Asp", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 126 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 406, "end_pos": 408 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCB4-1", "uniprot_ac": "A0AAF6ZCB4", "uniprot_id": "A0AAF6ZCB4_BOVIN", "mass": { "chemical_mass": 39587.0, "monoisotopic_mass": 39587.0 }, "refseq": { "ac": "XP_005213600", "name": "leukocyte cell-derived chemotaxin 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213600" }, "gene_names": [ { "name": "CNMD", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" } ] }, { "name": "CHM-I", "type": "synonym", "evidence": [ { "id": "XP_005213600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213600" } ] }, { "name": "CNMD", "type": "synonym", "evidence": [ { "id": "XP_005213600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213600" } ] }, { "name": "LECT1", "type": "synonym", "evidence": [ { "id": "XP_005213600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213600" } ] } ], "protein_names": [ { "name": "Leukocyte cell-derived chemotaxin 1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4/entry#names_and_taxonomy" } ] }, { "name": "Chondromodulin", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4/entry#names_and_taxonomy" } ] }, { "name": "leukocyte cell-derived chemotaxin 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005213600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213600" } ] } ], "function": [ { "annotation": "Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4#function" }, { "database": "UniProtKB", "id": "ARBA00045928", "url": "https://www.uniprot.org/uniprotkb/ARBA00045928#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNMD", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4", "locus": { "chromosome": "12", "start_pos": 11087040, "end_pos": 11051526, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025502", "url": "https://www.ensembl.org/id/ENSBTAG00000025502" } ] } } ], "crossref": [ { "id": "A0AAF6ZCB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "281683", "url": "https://www.ncbi.nlm.nih.gov/gene/281683", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14064:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14064:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213600", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213600", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGTSGPQARAQGASQASWCPAPAAAVMTENSDKVPIALVGPDDVEFCSPPAYAAVTVKPSSPARLLKVGAVVLISGAVLLLLGAIGAFYFWKGSDNHIYNVHYTMSINGKLQDGSMEIDAGNNLETFKMGSGAEEAVEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVGTMTKQSISSELEGKIMPVKYEENSLIWVAGDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQRERRELVRKIVTTTTTRRLRSGPQGTPAPGRPNNGTRPSVQEDAEPFNPDNPYHQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYHPWPYNYQGCRSACRVIMPCSWWVARILGMV", "length": 361, "header": "tr|A0AAF6ZCB4-1|A0AAF6ZCB4_BOVIN Isoform 1 of Leukocyte cell-derived chemotaxin 1 OS=Bos taurus OX=9913 GN=CNMD PE=3 SV=1 CANONICAL=A0AAF6ZCB4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZCB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4/entry", "sequence": { "sequence": "MPGTSGPQARAQGASQASWCPAPAAAVMTENSDKVPIALVGPDDVEFCSPPAYAAVTVKPSSPARLLKVGAVVLISGAVLLLLGAIGAFYFWKGSDNHIYNVHYTMSINGKLQDGSMEIDAGNNLETFKMGSGAEEAVEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVGTMTKQSISSELEGKIMPVKYEENSLIWVAGDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQRERRELVRKIVTTTTTRRLRSGPQGTPAPGRPNNGTRPSVQEDAEPFNPDNPYHQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYHPWPYNYQGCRSACRVIMPCSWWVARILGMV", "length": 361, "header": "tr|A0AAF6ZCB4-1|A0AAF6ZCB4_BOVIN Isoform 1 of Leukocyte cell-derived chemotaxin 1 OS=Bos taurus OX=9913 GN=CNMD PE=3 SV=1 CANONICAL=A0AAF6ZCB4-1" }, "locus": { "chromosome": "12", "start_pos": 11086491, "end_pos": 11051650, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035859.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035859.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035726.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035726.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 263, "start_aa": "Thr", "end_pos": 263, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr263", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 57, "start_aa": "Thr", "end_pos": 57, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr57", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" } ], "pmid": "" }, { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" } ], "pmid": "" }, { "name": "cartilage development", "id": "GO:0051216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCB4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCB4" }, { "id": "PS50869", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50869" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRICHOS", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 228, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 57, 263 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 271, "end_pos": 273 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCN3-1", "uniprot_ac": "A0AAF6ZCN3", "uniprot_id": "A0AAF6ZCN3_BOVIN", "mass": { "chemical_mass": 32644.0, "monoisotopic_mass": 32644.0 }, "refseq": {}, "gene_names": [ { "name": "ISOC1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3" } ] } ], "protein_names": [ { "name": "Isochorismatase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ISOC1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3", "locus": { "chromosome": "7", "start_pos": 24956654, "end_pos": 24993778, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000341", "url": "https://www.ensembl.org/id/ENSBTAG00000000341" } ] } } ], "crossref": [ { "id": "A0AAF6ZCN3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26960", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26960", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAEPAVPALPGGGGAGAGAPSGTVPVLFCFSVFARPAAVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKIHCWTTGLSGKEVQK", "length": 301, "header": "tr|A0AAF6ZCN3-1|A0AAF6ZCN3_BOVIN Isoform 1 of Isochorismatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=ISOC1 PE=3 SV=1 CANONICAL=A0AAF6ZCN3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZCN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3/entry", "sequence": { "sequence": "MAAAEPAVPALPGGGGAGAGAPSGTVPVLFCFSVFARPAAVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKIHCWTTGLSGKEVQK", "length": 301, "header": "tr|A0AAF6ZCN3-1|A0AAF6ZCN3_BOVIN Isoform 1 of Isochorismatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=ISOC1 PE=3 SV=1 CANONICAL=A0AAF6ZCN3-1" }, "locus": { "chromosome": "7", "start_pos": 24993714, "end_pos": 24956866, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035645.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035645.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035516.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035516.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3" }, { "id": "PF26960", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26960" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ISOC1 N-terminal ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 100, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCN3" }, { "id": "PF00857", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00857" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Isochorismatase-like", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 263, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCQ2-1", "uniprot_ac": "A0AAF6ZCQ2", "uniprot_id": "A0AAF6ZCQ2_BOVIN", "mass": { "chemical_mass": 25947.0, "monoisotopic_mass": 25947.0 }, "refseq": {}, "gene_names": [ { "name": "ALKBH7", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ] } ], "protein_names": [ { "name": "RNA demethylase ALKBH7, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2/entry#names_and_taxonomy" } ] }, { "name": "Alkylated DNA repair protein alkB homolog 7", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2/entry#names_and_taxonomy" } ] }, { "name": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity. In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. Involved in fatty acid metabolism.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2#function" }, { "database": "UniProtKB", "id": "ARBA00094242", "url": "https://www.uniprot.org/uniprotkb/ARBA00094242#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALKBH7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2", "locus": { "chromosome": "7", "start_pos": 18073869, "end_pos": 18076811, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025540", "url": "https://www.ensembl.org/id/ENSBTAG00000025540" } ] } } ], "crossref": [ { "id": "A0AAF6ZCQ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR027450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21052", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21052", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21052:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21052:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13532", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "54576", "url": "https://www.rhea-db.org/rhea/54576", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85431", "url": "https://www.rhea-db.org/rhea/85431", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SLFFFFNFSNQDPNKVQALPLVDKSGWVRGSGAAVLSRLQDAAVVRPGFLSTAEEETLSRELEPELRRRRYEYDHWDAAIHGFRETEKSRWSEASRAILRRVQAAAFGPGQTLLSSVHVLDLEPQGYIKPHVDSIKFCGSTIAGLSLLSPSVMRLVHTQEPGEWLELLLEPGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGEPGQLPPAC", "length": 231, "header": "tr|A0AAF6ZCQ2-1|A0AAF6ZCQ2_BOVIN Isoform 1 of RNA demethylase ALKBH7, mitochondrial OS=Bos taurus OX=9913 GN=ALKBH7 PE=3 SV=1 CANONICAL=A0AAF6ZCQ2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZCQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2/entry", "sequence": { "sequence": "SLFFFFNFSNQDPNKVQALPLVDKSGWVRGSGAAVLSRLQDAAVVRPGFLSTAEEETLSRELEPELRRRRYEYDHWDAAIHGFRETEKSRWSEASRAILRRVQAAAFGPGQTLLSSVHVLDLEPQGYIKPHVDSIKFCGSTIAGLSLLSPSVMRLVHTQEPGEWLELLLEPGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGEPGQLPPAC", "length": 231, "header": "tr|A0AAF6ZCQ2-1|A0AAF6ZCQ2_BOVIN Isoform 1 of RNA demethylase ALKBH7, mitochondrial OS=Bos taurus OX=9913 GN=ALKBH7 PE=3 SV=1 CANONICAL=A0AAF6ZCQ2-1" }, "locus": { "chromosome": "7", "start_pos": 18076738, "end_pos": 18073939, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035929.4", "url": "https://www.ensembl.org/id/ENSBTAT00000035929.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035795.3", "url": "https://www.ensembl.org/id/ENSBTAP00000035795.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" }, { "name": "regulation of lipid storage", "id": "GO:0010883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010883", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" }, { "name": "regulation of mitochondrial membrane permeability involved in programmed necrotic cell death", "id": "GO:1902445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902445", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" }, { "name": "oxidative RNA demethylation", "id": "GO:0035513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035513", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" }, { "name": "tRNA demethylase activity", "id": "GO:1990984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990984", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54576", "name": "", "equation": "an N(1)-methyladenosine in tRNA + 2-oxoglutarate + O2 = an adenosine in tRNA + formaldehyde + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6RQT4-1", "Q2M2S8-1" ], "evidence": [ { "id": "54576", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54576" } ] }, { "id": "85431", "name": "", "equation": "N(2)-dimethylguanosine in tRNA + 2 2-oxoglutarate + 2 O2 = guanosine in tRNA + 2 formaldehyde + 2 succinate + 2 CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2M2S8-1" ], "evidence": [ { "id": "85431", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85431" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F6RQT4", "gene_name": "ALKBH1", "activity": [ { "ec_number": "1.14.11.51", "activity": "an N(6)-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO2.", "evidence": [ { "id": "F6RQT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RQT4" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F6RQT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RQT4" } ] }, { "ec_number": "1.14.11.33", "activity": "a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2.", "evidence": [ { "id": "F6RQT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RQT4" } ] }, { "ec_number": "1.14.11.33", "activity": "", "evidence": [ { "id": "F6RQT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RQT4" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F6RQT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RQT4" } ] }, { "ec_number": "1.14.11.51", "activity": "", "evidence": [ { "id": "F6RQT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RQT4" } ] } ] }, { "uniprot_ac": "Q2M2S8", "gene_name": "ALKBH7", "activity": [ { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "Q2M2S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2M2S8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCQ2" }, { "id": "PF13532", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13532" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-ketoglutarate-dependent dioxygenase AlkB-like", "eco_id": "ECO_0000259", "start_pos": 85, "end_pos": 213, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZCW2-1", "uniprot_ac": "A0AAF6ZCW2", "uniprot_id": "A0AAF6ZCW2_BOVIN", "mass": { "chemical_mass": 68890.0, "monoisotopic_mass": 68890.0 }, "refseq": {}, "gene_names": [ { "name": "SLC22A17", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" } ] } ], "protein_names": [ { "name": "Solute carrier family 22 member 17", "type": "recommended", "evidence": [ { "id": "A0AAF6ZCW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2/entry#names_and_taxonomy" } ] }, { "name": "24p3 receptor", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2/entry#names_and_taxonomy" } ] }, { "name": "Lipocalin-2 receptor", "type": "synonym", "evidence": [ { "id": "A0AAF6ZCW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2#function" }, { "database": "UniProtKB", "id": "ARBA00054975", "url": "https://www.uniprot.org/uniprotkb/ARBA00054975#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC22A17", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2", "locus": { "chromosome": "10", "start_pos": 21578551, "end_pos": 21572374, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016467", "url": "https://www.ensembl.org/id/ENSBTAG00000016467" } ] } } ], "crossref": [ { "id": "A0AAF6ZCW2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZCW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17445", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17445", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPRVATGTPEPNGGGGSKIDSTVEITPSPNGQVGTLGDAVPTEQLQGEREREREREGEGHAGGDGMGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGLASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRLATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLALLGLWDCKHPPFPALWAQPRNPSRDLNEAAITTFSVLGLFSSQAAGILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLQQPPPNRCDHVPLLATPNPAL", "length": 651, "header": "tr|A0AAF6ZCW2-1|A0AAF6ZCW2_BOVIN Isoform 1 of Solute carrier family 22 member 17 OS=Bos taurus OX=9913 GN=SLC22A17 PE=3 SV=2 CANONICAL=A0AAF6ZCW2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZCW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2/entry", "sequence": { "sequence": "MAPRVATGTPEPNGGGGSKIDSTVEITPSPNGQVGTLGDAVPTEQLQGEREREREREGEGHAGGDGMGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGLASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRLATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLALLGLWDCKHPPFPALWAQPRNPSRDLNEAAITTFSVLGLFSSQAAGILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLQQPPPNRCDHVPLLATPNPAL", "length": 651, "header": "tr|A0AAF6ZCW2-1|A0AAF6ZCW2_BOVIN Isoform 1 of Solute carrier family 22 member 17 OS=Bos taurus OX=9913 GN=SLC22A17 PE=3 SV=2 CANONICAL=A0AAF6ZCW2-1" }, "locus": { "chromosome": "10", "start_pos": 21578210, "end_pos": 21572527, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036406.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036406.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036264.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036264.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" } ], "pmid": "" }, { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZCW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZCW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCW2" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 611, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 145, "end_pos": 147 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZDH4-1", "uniprot_ac": "A0AAF6ZDH4", "uniprot_id": "A0AAF6ZDH4_BOVIN", "mass": { "chemical_mass": 31279.0, "monoisotopic_mass": 31279.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Secreted frizzled related protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZDH4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZDH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07443", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07443", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR015526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11309", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11309", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11309:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11309:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFGWSLSSAPQKTEPQTPRKCVLWKRRHERHPFEGSAPFSLPLFCMELTYKIEAAGAVLLRTGSHDSSCGVPEAGFVTEFLPGNM", "length": 284, "header": "tr|A0AAF6ZDH4-1|A0AAF6ZDH4_BOVIN Isoform 1 of Secreted frizzled related protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6ZDH4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZDH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4/entry", "sequence": { "sequence": "MGGGRWAAAGALLALAAGLLAAGSASEYDYVSFQSDIGAYQSGRFYTKPPQCVDIPADLRLCHNVGYKRMVLPNLLEHETMAEVKQQASSWVPLLNKNCHIGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFGWSLSSAPQKTEPQTPRKCVLWKRRHERHPFEGSAPFSLPLFCMELTYKIEAAGAVLLRTGSHDSSCGVPEAGFVTEFLPGNM", "length": 284, "header": "tr|A0AAF6ZDH4-1|A0AAF6ZDH4_BOVIN Isoform 1 of Secreted frizzled related protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6ZDH4-1" }, "locus": { "chromosome": "27", "start_pos": 36255096, "end_pos": 36248621, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039787.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039787.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039575.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039575.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 43, "go_terms": [ { "name": "positive regulation of smoothened signaling pathway", "id": "GO:0045880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of bone remodeling", "id": "GO:0046851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046851", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of epithelial cell proliferation", "id": "GO:0050680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050680", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "hematopoietic stem cell differentiation", "id": "GO:0060218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060218", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to prostaglandin E stimulus", "id": "GO:0071380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071380", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of fibroblast proliferation", "id": "GO:0048147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048147", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to BMP stimulus", "id": "GO:0071773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071773", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:1902043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902043", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "osteoblast differentiation", "id": "GO:0001649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to starvation", "id": "GO:0009267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "regulation of neuron projection development", "id": "GO:0010975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to estradiol stimulus", "id": "GO:0071392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071392", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of osteoblast proliferation", "id": "GO:0033689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033689", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to interleukin-1", "id": "GO:0071347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071347", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to estrogen stimulus", "id": "GO:0071391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071391", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "ureteric bud development", "id": "GO:0001657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001657", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of fibroblast apoptotic process", "id": "GO:2000270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000270", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of fibroblast apoptotic process", "id": "GO:2000271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000271", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "regulation of midbrain dopaminergic neuron differentiation", "id": "GO:1904956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904956", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to vitamin D", "id": "GO:0071305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071305", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cellular response to X-ray", "id": "GO:0071481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071481", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "regulation of cell cycle process", "id": "GO:0010564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010564", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of ossification", "id": "GO:0030279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030279", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "dorsal/ventral axis specification", "id": "GO:0009950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009950", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of epithelial to mesenchymal transition", "id": "GO:0010719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010719", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "dopaminergic neuron differentiation", "id": "GO:0071542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071542", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of androgen receptor signaling pathway", "id": "GO:0060766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060766", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "positive regulation of non-canonical Wnt signaling pathway", "id": "GO:2000052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000052", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "negative regulation of B cell differentiation", "id": "GO:0045578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045578", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "frizzled binding", "id": "GO:0005109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005109", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "Wnt-protein binding", "id": "GO:0017147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017147", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDH4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDH4" }, { "id": "PS50038", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FZ", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 163, "start_aa": "Thr", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZDJ1-1", "uniprot_ac": "A0AAF6ZDJ1", "uniprot_id": "A0AAF6ZDJ1_BOVIN", "mass": { "chemical_mass": 70353.0, "monoisotopic_mass": 70353.0 }, "refseq": {}, "gene_names": [ { "name": "IFT70B", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 30", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1#function" }, { "database": "UniProtKB", "id": "RU367070", "url": "https://www.uniprot.org/uniprotkb/RU367070#function" }, { "database": "UniProtKB", "id": "ARBA00002105", "url": "https://www.uniprot.org/uniprotkb/ARBA00002105#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT70B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1", "locus": { "chromosome": "2", "start_pos": 19328351, "end_pos": 19259244, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027694", "url": "https://www.ensembl.org/id/ENSBTAG00000027694" } ] } } ], "crossref": [ { "id": "A0AAF6ZDJ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZDJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20931", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20931", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20931:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20931:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLGGEPIPDGEFTAVVYRLIRDARYAEAVQLLGGELQRSPRSRAGLSLLGYCYYRLQEFALAAECYEQLRQLHPELEQYRLYQAQALYKACLYPEATRVSFLLLDNPTYHNRVLRLQAAIKYSEGDLPGARSLVEQLLSEGGEDSGGENELDGQVNLGCLLYKEGHYEAACSKFSAALQASGYRPDLSYNLALAYFSSRQYASALKHIVEIIEHGIRQHPELGVGMTTEGIDVRSVGNTLVLHQTALVEAFNLKAAIEYQLRNYEAAQETLTDMPPRAEEELDPVTLHNQALMNMDARPTEGFEKLQFLLQQIPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFVKLDGLAGMLTEQLRRLTKQVQEARHNKDDEAIKKAENEYDDTLEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKHYDNILKVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYDDPDKKIYHFCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKHMIVLRDSVIQECVHF", "length": 614, "header": "tr|A0AAF6ZDJ1-1|A0AAF6ZDJ1_BOVIN Isoform 1 of Tetratricopeptide repeat protein 30 OS=Bos taurus OX=9913 GN=IFT70B PE=3 SV=1 CANONICAL=A0AAF6ZDJ1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZDJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1/entry", "sequence": { "sequence": "MAGLGGEPIPDGEFTAVVYRLIRDARYAEAVQLLGGELQRSPRSRAGLSLLGYCYYRLQEFALAAECYEQLRQLHPELEQYRLYQAQALYKACLYPEATRVSFLLLDNPTYHNRVLRLQAAIKYSEGDLPGARSLVEQLLSEGGEDSGGENELDGQVNLGCLLYKEGHYEAACSKFSAALQASGYRPDLSYNLALAYFSSRQYASALKHIVEIIEHGIRQHPELGVGMTTEGIDVRSVGNTLVLHQTALVEAFNLKAAIEYQLRNYEAAQETLTDMPPRAEEELDPVTLHNQALMNMDARPTEGFEKLQFLLQQIPFPPETFGNLLLLYCKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFVKLDGLAGMLTEQLRRLTKQVQEARHNKDDEAIKKAENEYDDTLEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKHYDNILKVSAIVLANLCVSYIMTSQNEEAEELMRKIEKEEEQLSYDDPDKKIYHFCIVNLVIGTLYCAKGNYDFGISRVIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKHMIVLRDSVIQECVHF", "length": 614, "header": "tr|A0AAF6ZDJ1-1|A0AAF6ZDJ1_BOVIN Isoform 1 of Tetratricopeptide repeat protein 30 OS=Bos taurus OX=9913 GN=IFT70B PE=3 SV=1 CANONICAL=A0AAF6ZDJ1-1" }, "locus": { "chromosome": "2", "start_pos": 19327585, "end_pos": 19259443, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039896.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039896.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039681.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039681.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "axonemal microtubule", "id": "GO:0005879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1" } ], "pmid": "" }, { "name": "intraciliary transport particle B", "id": "GO:0030992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 595, "end_pos": 597, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 595, "end_pos": 597 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZDZ2-1", "uniprot_ac": "A0AAF6ZDZ2", "uniprot_id": "A0AAF6ZDZ2_BOVIN", "mass": { "chemical_mass": 24021.0, "monoisotopic_mass": 24021.0 }, "refseq": {}, "gene_names": [ { "name": "LOC617402", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2" } ] } ], "protein_names": [ { "name": "Cystatin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC617402", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZDZ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZDZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47393:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47393:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZDZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGNRACGSLVPKAYLTRGGNWDIPPPHPQLNFPSGDNGRIREEELGRGPGGQQSTVRGRAVLDGELRRRPPKHSASRTTLDNMFWKLPLLLGLLALGPHVCSWMFEDIGKTGQEFSMCVEFAIHHFNEHQPDENAYKLLWVRRSQHKKFSLTYLMDLHLGRTICKKHDEDIDNCPLQEGPEGKKVNCTFIVDSRPLYTKFTLLNSTCQQI", "length": 211, "header": "tr|A0AAF6ZDZ2-1|A0AAF6ZDZ2_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC617402 PE=3 SV=1 CANONICAL=A0AAF6ZDZ2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZDZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2/entry", "sequence": { "sequence": "MRGNRACGSLVPKAYLTRGGNWDIPPPHPQLNFPSGDNGRIREEELGRGPGGQQSTVRGRAVLDGELRRRPPKHSASRTTLDNMFWKLPLLLGLLALGPHVCSWMFEDIGKTGQEFSMCVEFAIHHFNEHQPDENAYKLLWVRRSQHKKFSLTYLMDLHLGRTICKKHDEDIDNCPLQEGPEGKKVNCTFIVDSRPLYTKFTLLNSTCQQI", "length": 211, "header": "tr|A0AAF6ZDZ2-1|A0AAF6ZDZ2_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC617402 PE=3 SV=1 CANONICAL=A0AAF6ZDZ2-1" }, "locus": { "chromosome": "13", "start_pos": 42116108, "end_pos": 42111682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039366.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039366.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039161.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039161.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZDZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDZ2" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 209, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 }, { "start_pos": 205, "end_pos": 207 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZEI4-1", "uniprot_ac": "A0AAF6ZEI4", "uniprot_id": "A0AAF6ZEI4_BOVIN", "mass": { "chemical_mass": 57399.0, "monoisotopic_mass": 57399.0 }, "refseq": {}, "gene_names": [ { "name": "KRT27", "type": "recommended", "evidence": [ { "id": "A0AAF6ZEI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4" } ] } ], "protein_names": [ { "name": "Keratin 27", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZE34", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE34#function" }, { "database": "UniProtKB", "id": "ARBA00037136", "url": "https://www.uniprot.org/uniprotkb/ARBA00037136#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT27", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4", "locus": { "chromosome": "19", "start_pos": 40963732, "end_pos": 40982772, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030548", "url": "https://www.ensembl.org/id/ENSBTAG00000030548" } ] } } ], "crossref": [ { "id": "A0AAF6ZEI4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZEI4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF120", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF120", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZE34", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZE34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZEI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZEI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTSDELTNNILLWVAEFTKKHPDNVYIKVHETVSVGHLPSELTSRNKQGSLDTMSVRFSSASRRLGSCGGAGSVRLSGGGAGFGVGSTGSVPGFGSGFTCAFGGSSSAGSYSGGLGGGSASCTAFTGNEHGLLSGNEKVTLQNLNDRLASYLDHVCTLEEANADLEQKIKGWYEKYGPGSGRQLAYDCSKYFSVTEDLKRQIISVTTCNASIALQNENARLTADDFRLKYENELALNQSVEADINGLHRVMEELTLCTSDLEIQCEALSEELTCLKKNHQEEMKVMQGAAGGNVNVEINAAPGVDLTVLLNNMRAEYEDLAEQNREDAEAWFNEKSTSLHQQISDDAGAATAARNELMELKRNLQTLEIELQSLMAMKHSYECSLAETESNYCHQLQQIQEQIGATEDQLQQIRMETEGQKLEHERLLDVKIFLEKEIEMYCKLIDGEGRKSKSTYCKSEGRGPKNSENQVKDSKEEAVVKTVVGELDQLGSVLSLRVHSVEEKSSKISNITMEQRLPSKVPQ", "length": 524, "header": "tr|A0AAF6ZEI4-1|A0AAF6ZEI4_BOVIN Isoform 1 of Keratin 27 OS=Bos taurus OX=9913 GN=KRT27 PE=4 SV=1 CANONICAL=A0AAF6ZEI4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZE34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE34/entry", "sequence": { "sequence": "MNTSDELTNNILLWVAEFTKKHPDNVYIKVHETVSVGHLPSELTSRNKQGSLDTMSVRFSSASRRLGSCGGAGSVRLSGGGAGFGVGSTGSVPGFGSGFTCAFGGSSSAGSYSGGLGGGSASCTAFTGNEHGLLSGNEKVTMQNLNDRLASYLDNVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFTVIDDLRNQIISATTSNANIVLQNDNARLTADDFRLKFENEQALHQSVDADVSSLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARNELTEMKRNLQTLEIELQSLLATKHSLECSLTETEGNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCRLIDGEDGSCAKSKGYGGPGHQIKDPSKATVVKTIVEEIDPRGKVLSSRVHSVEEKSTKVNNVKSEQRVPS", "length": 514, "header": "tr|A0AAF6ZE34-1|A0AAF6ZEI4_BOVIN Computationally mapped isoform of Keratin 27 OS=Bos taurus OX=9913 GN=KRT27 PE=4 SV=1 CANONICAL=A0AAF6ZEI4-1" }, "locus": { "chromosome": "19", "start_pos": 40982687, "end_pos": 40977112, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043127.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043127.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040718.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040718.2" } ] } }, { "isoform_ac": "A0AAF6ZEI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4/entry", "sequence": { "sequence": "MNTSDELTNNILLWVAEFTKKHPDNVYIKVHETVSVGHLPSELTSRNKQGSLDTMSVRFSSASRRLGSCGGAGSVRLSGGGAGFGVGSTGSVPGFGSGFTCAFGGSSSAGSYSGGLGGGSASCTAFTGNEHGLLSGNEKVTLQNLNDRLASYLDHVCTLEEANADLEQKIKGWYEKYGPGSGRQLAYDCSKYFSVTEDLKRQIISVTTCNASIALQNENARLTADDFRLKYENELALNQSVEADINGLHRVMEELTLCTSDLEIQCEALSEELTCLKKNHQEEMKVMQGAAGGNVNVEINAAPGVDLTVLLNNMRAEYEDLAEQNREDAEAWFNEKSTSLHQQISDDAGAATAARNELMELKRNLQTLEIELQSLMAMKHSYECSLAETESNYCHQLQQIQEQIGATEDQLQQIRMETEGQKLEHERLLDVKIFLEKEIEMYCKLIDGEGRKSKSTYCKSEGRGPKNSENQVKDSKEEAVVKTVVGELDQLGSVLSLRVHSVEEKSSKISNITMEQRLPSKVPQ", "length": 524, "header": "tr|A0AAF6ZEI4-1|A0AAF6ZEI4_BOVIN Isoform 1 of Keratin 27 OS=Bos taurus OX=9913 GN=KRT27 PE=4 SV=1 CANONICAL=A0AAF6ZEI4-1" }, "locus": { "chromosome": "19", "start_pos": 40982687, "end_pos": 40964077, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043126.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043126.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040717.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040717.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEI4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZEI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEI4" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 138, "end_pos": 453, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 210, "end_pos": 212 }, { "start_pos": 238, "end_pos": 240 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 511, "end_pos": 513 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZEA8-1", "uniprot_ac": "A0AAF6ZEA8", "uniprot_id": "A0AAF6ZEA8_BOVIN", "mass": { "chemical_mass": 33879.0, "monoisotopic_mass": 33879.0 }, "refseq": {}, "gene_names": [ { "name": "AK4", "type": "recommended", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "name": "AK3L1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] } ], "protein_names": [ { "name": "Adenylate kinase 4, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry#names_and_taxonomy" } ] }, { "name": "2.7.4.10", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry#names_and_taxonomy" } ] }, { "name": "2.7.4.6", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry#names_and_taxonomy" } ] }, { "name": "AK 4", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry#names_and_taxonomy" } ] }, { "name": "Adenylate kinase 3-like", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry#names_and_taxonomy" } ] }, { "name": "GTP:AMP phosphotransferase AK4", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8#function" }, { "database": "UniProtKB", "id": "ARBA00045931", "url": "https://www.uniprot.org/uniprotkb/ARBA00045931#function" } ] }, { "annotation": "Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8#function" }, { "database": "HAMAP", "id": "MF_03170", "url": "https://hamap.expasy.org/signature/MF_03170" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AK4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8", "locus": { "chromosome": "3", "start_pos": 80160692, "end_pos": 80252581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030674", "url": "https://www.ensembl.org/id/ENSBTAG00000030674" } ] } } ], "crossref": [ { "id": "A0AAF6ZEA8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZEA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01428", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01428", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00406", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00406", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "11600", "url": "https://www.rhea-db.org/rhea/11600", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "12973", "url": "https://www.rhea-db.org/rhea/12973", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "13749", "url": "https://www.rhea-db.org/rhea/13749", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "18113", "url": "https://www.rhea-db.org/rhea/18113", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "23100", "url": "https://www.rhea-db.org/rhea/23100", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24036", "url": "https://www.rhea-db.org/rhea/24036", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25094", "url": "https://www.rhea-db.org/rhea/25094", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25098", "url": "https://www.rhea-db.org/rhea/25098", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25237", "url": "https://www.rhea-db.org/rhea/25237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "27678", "url": "https://www.rhea-db.org/rhea/27678", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "27682", "url": "https://www.rhea-db.org/rhea/27682", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "27686", "url": "https://www.rhea-db.org/rhea/27686", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "27690", "url": "https://www.rhea-db.org/rhea/27690", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29863", "url": "https://www.rhea-db.org/rhea/29863", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44640", "url": "https://www.rhea-db.org/rhea/44640", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79855", "url": "https://www.rhea-db.org/rhea/79855", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79859", "url": "https://www.rhea-db.org/rhea/79859", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79863", "url": "https://www.rhea-db.org/rhea/79863", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79867", "url": "https://www.rhea-db.org/rhea/79867", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79871", "url": "https://www.rhea-db.org/rhea/79871", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79875", "url": "https://www.rhea-db.org/rhea/79875", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZEA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDSMNEGPYSKPPFSSIVHALPGTVTASRKSPSSETDAQGGGESPREPRVSEAGAEETKFPGLLRGRCPGCQFGLPLLSEAMASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKANTEVGDMAKQYIEKGLLVPDHVITRLMLLELENRRGEHWLLDGFPRTLVQAEALDRLCDLDLVITLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGMDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPVQSKEAY", "length": 305, "header": "tr|A0AAF6ZEA8-1|A0AAF6ZEA8_BOVIN Isoform 1 of Adenylate kinase 4, mitochondrial OS=Bos taurus OX=9913 GN=AK4 PE=3 SV=1 CANONICAL=A0AAF6ZEA8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZEA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8/entry", "sequence": { "sequence": "MTDSMNEGPYSKPPFSSIVHALPGTVTASRKSPSSETDAQGGGESPREPRVSEAGAEETKFPGLLRGRCPGCQFGLPLLSEAMASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKANTEVGDMAKQYIEKGLLVPDHVITRLMLLELENRRGEHWLLDGFPRTLVQAEALDRLCDLDLVITLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGMDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPVQSKEAY", "length": 305, "header": "tr|A0AAF6ZEA8-1|A0AAF6ZEA8_BOVIN Isoform 1 of Adenylate kinase 4, mitochondrial OS=Bos taurus OX=9913 GN=AK4 PE=3 SV=1 CANONICAL=A0AAF6ZEA8-1" }, "locus": { "chromosome": "3", "start_pos": 80252382, "end_pos": 80161992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043366.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043366.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040941.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040941.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "AMP kinase activity", "id": "GO:0004017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004017", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "nucleoside triphosphate adenylate kinase activity", "id": "GO:0046899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "nucleoside diphosphate kinase activity", "id": "GO:0004550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004550", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ADP biosynthetic process", "id": "GO:0006172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006172", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "AMP metabolic process", "id": "GO:0046033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046033", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "ATP metabolic process", "id": "GO:0046034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046034", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" }, { "name": "GTP metabolic process", "id": "GO:0046039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046039", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEA8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11600", "name": "", "equation": "CMP + ATP = CDP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1N2W6-1", "F1MUF5-1" ], "evidence": [ { "id": "11600", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11600" } ] }, { "id": "12973", "name": "", "equation": "AMP + ATP = 2 ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LVZ0-1", "A4IFD0-1", "Q0VCP1-1", "A0AAF6ZEA8-1", "P00570-1", "A5PJA1-1", "P08166-1", "A0AAA9SPL6-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "12973", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12973" } ] }, { "id": "13749", "name": "", "equation": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZEA8-1", "A0A3Q1LVZ0-1", "P08760-1" ], "evidence": [ { "id": "13749", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13749" } ] }, { "id": "18113", "name": "", "equation": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFD0-1", "Q3T0Q4-1", "A0AAF6ZEA8-1", "P00570-1", "Q2KIW9-1", "A0A3Q1LVZ0-1", "P52175-1", "Q0VCP1-1", "A0AAA9SPL6-1", "F1N2W6-1", "F1N6T4-1", "F1MUF5-1", "A0AAA9TUI5-1" ], "evidence": [ { "id": "18113", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18113" } ] }, { "id": "23100", "name": "", "equation": "dAMP + ATP = dADP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "23100", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23100" } ] }, { "id": "24036", "name": "", "equation": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "A0A3Q1LVZ0-1", "Q0VCP1-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "24036", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24036" } ] }, { "id": "25094", "name": "", "equation": "dCMP + ATP = dCDP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1N2W6-1", "F1MUF5-1" ], "evidence": [ { "id": "25094", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25094" } ] }, { "id": "25098", "name": "", "equation": "UDP + ATP = UTP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "P00570-1", "Q2KIW9-1", "F1MUF5-1", "P52175-1", "Q3T0Q4-1", "A0AAA9TUI5-1", "F1N6T4-1" ], "evidence": [ { "id": "25098", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25098" } ] }, { "id": "25237", "name": "", "equation": "CDP + ATP = CTP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "F1MUF5-1", "P52175-1", "Q3T0Q4-1", "A0AAA9TUI5-1", "F1N6T4-1" ], "evidence": [ { "id": "25237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25237" } ] }, { "id": "27678", "name": "", "equation": "dCDP + ATP = dCTP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "F1MUF5-1", "P52175-1", "F1N6T4-1" ], "evidence": [ { "id": "27678", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27678" } ] }, { "id": "27682", "name": "", "equation": "dTDP + ATP = dTTP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "F1MUF5-1", "P52175-1", "Q3T0Q4-1", "F1N6T4-1" ], "evidence": [ { "id": "27682", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27682" } ] }, { "id": "27686", "name": "", "equation": "GDP + ATP = GTP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "P00570-1", "Q2KIW9-1", "F1MUF5-1", "P52175-1", "Q3T0Q4-1", "A0AAA9TUI5-1", "F1N6T4-1" ], "evidence": [ { "id": "27686", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27686" } ] }, { "id": "27690", "name": "", "equation": "dGDP + ATP = dGTP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "P00570-1", "Q2KIW9-1", "F1MUF5-1", "F1N6T4-1" ], "evidence": [ { "id": "27690", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27690" } ] }, { "id": "29863", "name": "", "equation": "GTP + AMP = GDP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08760-1", "Q0VCP1-1", "P08166-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "F1MUF5-1" ], "evidence": [ { "id": "29863", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29863" } ] }, { "id": "44640", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TUI5-1", "A4IFD0-1", "Q3T0Q4-1", "A0AAF6ZEA8-1", "P00570-1", "P52175-1", "Q2KIW9-1", "A0A3Q1LVZ0-1", "Q0VCP1-1", "A0AAA9SPL6-1", "F1N2W6-1", "F1N6T4-1" ], "evidence": [ { "id": "44640", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44640" } ] }, { "id": "79855", "name": "", "equation": "GTP + CMP = CDP + GDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "F1MUF5-1" ], "evidence": [ { "id": "79855", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79855" } ] }, { "id": "79859", "name": "", "equation": "CDP + GTP = CTP + GDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "A0A3Q1LVZ0-1", "Q0VCP1-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "79859", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79859" } ] }, { "id": "79863", "name": "", "equation": "GTP + UDP = UTP + GDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "79863", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79863" } ] }, { "id": "79867", "name": "", "equation": "dTDP + GTP = dTTP + GDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "79867", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79867" } ] }, { "id": "79871", "name": "", "equation": "dADP + GTP = dATP + GDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "A0A3Q1LVZ0-1", "Q0VCP1-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "79871", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79871" } ] }, { "id": "79875", "name": "", "equation": "dCDP + GTP = dCTP + GDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00570-1", "A0A3Q1LVZ0-1", "Q0VCP1-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1MUF5-1" ], "evidence": [ { "id": "79875", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79875" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVZ0", "gene_name": "AK4", "activity": [ { "ec_number": "2.7.4.10", "activity": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] }, { "ec_number": "2.7.4.10", "activity": "", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] } ] }, { "uniprot_ac": "A0AAA9SPL6", "gene_name": "AK8", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] } ] }, { "uniprot_ac": "A0AAA9TUI5", "gene_name": "NME6", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0AAA9TUI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI5" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0AAA9TUI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI5" } ] } ] }, { "uniprot_ac": "A0AAF6ZEA8", "gene_name": "AK4", "activity": [ { "ec_number": "2.7.4.10", "activity": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "ec_number": "2.7.4.10", "activity": "", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] } ] }, { "uniprot_ac": "A4IFD0", "gene_name": "Ak5", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "F1MUF5", "gene_name": "AK9", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] }, { "ec_number": "2.7.4.4", "activity": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] }, { "ec_number": "2.7.4.4", "activity": "", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] } ] }, { "uniprot_ac": "F1N2W6", "gene_name": "CMPK2", "activity": [ { "ec_number": "2.7.4.14", "activity": "UMP + ATP = UDP + ADP.", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ] }, { "ec_number": "2.7.4.14", "activity": "", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ] } ] }, { "uniprot_ac": "F1N6T4", "gene_name": "NME4", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "F1N6T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "F1N6T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T4" } ] } ] }, { "uniprot_ac": "P00570", "gene_name": "AK1", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.4", "activity": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.4", "activity": "", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] } ] }, { "uniprot_ac": "P08166", "gene_name": "AK2", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "P08166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08166" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "P08166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08166" } ] } ] }, { "uniprot_ac": "P08760", "gene_name": "AK3", "activity": [ { "ec_number": "2.7.4.10", "activity": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "P08760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08760" } ] }, { "ec_number": "2.7.4.10", "activity": "", "evidence": [ { "id": "P08760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08760" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "Q0VCP1", "gene_name": "AK4", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] }, { "ec_number": "2.7.4.4", "activity": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] }, { "ec_number": "2.7.4.4", "activity": "", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] } ] }, { "uniprot_ac": "Q2KIW9", "gene_name": "CMPK1", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q2KIW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW9" } ] }, { "ec_number": "2.7.4.14", "activity": "UMP + ATP = UDP + ADP.", "evidence": [ { "id": "Q2KIW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW9" } ] }, { "ec_number": "2.7.4.14", "activity": "", "evidence": [ { "id": "Q2KIW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW9" } ] } ] }, { "uniprot_ac": "Q3T0Q4", "gene_name": "NME2", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" }, { "id": "PF05191", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Adenylate kinase active site lid", "eco_id": "ECO_0000259", "start_pos": 208, "end_pos": 243, "start_aa": "Arg", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.4.10", "ec_name": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "2.7.4.10", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10" }, { "id": "2.7.4.10", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.4.10" } ] }, { "ec_number": "2.7.4.6", "ec_name": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "2.7.4.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6" }, { "id": "2.7.4.6", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.4.6" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZEM0-1", "uniprot_ac": "A0AAF6ZEM0", "uniprot_id": "A0AAF6ZEM0_BOVIN", "mass": { "chemical_mass": 49787.0, "monoisotopic_mass": 49787.0 }, "refseq": {}, "gene_names": [ { "name": "KRT25", "type": "recommended", "evidence": [ { "id": "A0AAF6ZEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ] } ], "protein_names": [ { "name": "Keratin, type I cytoskeletal 25", "type": "recommended", "evidence": [ { "id": "A0AAF6ZEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0/entry#names_and_taxonomy" } ] }, { "name": "Cytokeratin-25", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0/entry#names_and_taxonomy" } ] }, { "name": "Keratin-25", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0/entry#names_and_taxonomy" } ] }, { "name": "Type I inner root sheath-specific keratin-K25irs1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Plays a role in the cytoskeleton organization.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0#function" }, { "database": "UniProtKB", "id": "ARBA00045325", "url": "https://www.uniprot.org/uniprotkb/ARBA00045325#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0", "locus": { "chromosome": "19", "start_pos": 40945832, "end_pos": 40954058, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030542", "url": "https://www.ensembl.org/id/ENSBTAG00000030542" } ] } } ], "crossref": [ { "id": "A0AAF6ZEM0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZEM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF160", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF160", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZEM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPDFYSVVDCGSRRASPRPTTGSLRLSSGGASFGAGNACSMPGIGSSFSCAFGGSSSGGNALGGNPCAGFTVNEGGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIEDLKNQIIASTTSNANAVLQIDNARLTADDFRLKYENELALHQSVESDVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHKEEMQVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQITEDVGATTSARNELTEMKRNLQTLEIELQSLLATKHSLECSLTETEGNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIGGDDGACKSGGYKSKDYGAGNVGNQMKDPVKAIVVKKVLEEVDQRSKILTPRLHSLEEKSQSN", "length": 454, "header": "tr|A0AAF6ZEM0-1|A0AAF6ZEM0_BOVIN Isoform 1 of Keratin, type I cytoskeletal 25 OS=Bos taurus OX=9913 GN=KRT25 PE=4 SV=1 CANONICAL=A0AAF6ZEM0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZEM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0/entry", "sequence": { "sequence": "MTPDFYSVVDCGSRRASPRPTTGSLRLSSGGASFGAGNACSMPGIGSSFSCAFGGSSSGGNALGGNPCAGFTVNEGGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIEDLKNQIIASTTSNANAVLQIDNARLTADDFRLKYENELALHQSVESDVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHKEEMQVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQITEDVGATTSARNELTEMKRNLQTLEIELQSLLATKHSLECSLTETEGNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIGGDDGACKSGGYKSKDYGAGNVGNQMKDPVKAIVVKKVLEEVDQRSKILTPRLHSLEEKSQSN", "length": 454, "header": "tr|A0AAF6ZEM0-1|A0AAF6ZEM0_BOVIN Isoform 1 of Keratin, type I cytoskeletal 25 OS=Bos taurus OX=9913 GN=KRT25 PE=4 SV=1 CANONICAL=A0AAF6ZEM0-1" }, "locus": { "chromosome": "19", "start_pos": 40953962, "end_pos": 40946114, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043116.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043116.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040707.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040707.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "pmid": "" }, { "name": "hair cycle", "id": "GO:0042633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042633", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEM0" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 83, "end_pos": 398, "start_aa": "Glu", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZFF4-1", "uniprot_ac": "A0AAF6ZFF4", "uniprot_id": "A0AAF6ZFF4_BOVIN", "mass": { "chemical_mass": 44082.0, "monoisotopic_mass": 44082.0 }, "refseq": {}, "gene_names": [ { "name": "LAMP1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ] } ], "protein_names": [ { "name": "Lysosome-associated membrane glycoprotein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4/entry#names_and_taxonomy" } ] }, { "name": "CD107 antigen-like family member A", "type": "synonym", "evidence": [ { "id": "A0AAF6ZFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAMP1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4", "locus": { "chromosome": "12", "start_pos": 86605278, "end_pos": 86593170, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010242", "url": "https://www.ensembl.org/id/ENSBTAG00000010242" } ] } } ], "crossref": [ { "id": "A0AAF6ZFF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZFF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11506", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11506", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11506:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11506:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01299", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01299", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPGGARRRPLLLLLFGLVHGASAVFVVKNGNGTACIMADFSATFLTSYDTRSGPQNKSFELPAGAEVSNSSSCGKENASDSSLVITFGRGHTLTLIFTRNATRYEVQLMRFAYNLSDTDTFPNSSSTGVKTVESATDIKADINKTYRCVSETQVNMDNVTVTLRDAAIQAYLSSSNFSREETRCEQDLPTPTTPPQPAPTPAPASPAVFRYNVSGSNGTCLLASMGLQLNVTYRRVDNKTVTREFNVNPNKTTFGGNCSATLATLELHSENLLLLALQFVMNESSSRVFLQGVQLNLTLPDAKEGSFTATNSSLRALQATAGNSYKCNAEQRLRVTSSFSLNMFRVWLQAFRVDGDKFGPVEECQLDENSMLIPIAVGGALAGLVLIVLLAYLIGRKRSHAGYQTI", "length": 408, "header": "tr|A0AAF6ZFF4-1|A0AAF6ZFF4_BOVIN Isoform 1 of Lysosome-associated membrane glycoprotein 1 OS=Bos taurus OX=9913 GN=LAMP1 PE=3 SV=1 CANONICAL=A0AAF6ZFF4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZFF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4/entry", "sequence": { "sequence": "MAAPGGARRRPLLLLLFGLVHGASAVFVVKNGNGTACIMADFSATFLTSYDTRSGPQNKSFELPAGAEVSNSSSCGKENASDSSLVITFGRGHTLTLIFTRNATRYEVQLMRFAYNLSDTDTFPNSSSTGVKTVESATDIKADINKTYRCVSETQVNMDNVTVTLRDAAIQAYLSSSNFSREETRCEQDLPTPTTPPQPAPTPAPASPAVFRYNVSGSNGTCLLASMGLQLNVTYRRVDNKTVTREFNVNPNKTTFGGNCSATLATLELHSENLLLLALQFVMNESSSRVFLQGVQLNLTLPDAKEGSFTATNSSLRALQATAGNSYKCNAEQRLRVTSSFSLNMFRVWLQAFRVDGDKFGPVEECQLDENSMLIPIAVGGALAGLVLIVLLAYLIGRKRSHAGYQTI", "length": 408, "header": "tr|A0AAF6ZFF4-1|A0AAF6ZFF4_BOVIN Isoform 1 of Lysosome-associated membrane glycoprotein 1 OS=Bos taurus OX=9913 GN=LAMP1 PE=3 SV=1 CANONICAL=A0AAF6ZFF4-1" }, "locus": { "chromosome": "12", "start_pos": 86604565, "end_pos": 86593419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045121.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045121.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042536.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042536.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 202, "start_aa": "Thr", "end_pos": 202, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr202", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "establishment of protein localization to organelle", "id": "GO:0072594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072594", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "Golgi to lysosome transport", "id": "GO:0090160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090160", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell degranulation", "id": "GO:0043323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043323", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "lysosomal lumen acidification", "id": "GO:0007042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007042", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "regulation of organelle transport along microtubule", "id": "GO:1902513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902513", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "granzyme-mediated programmed cell death signaling pathway", "id": "GO:0140507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140507", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "autolysosome", "id": "GO:0044754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044754", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "phagolysosome membrane", "id": "GO:0061474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061474", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "cytolytic granule membrane", "id": "GO:0101004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101004", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" }, { "name": "ion channel inhibitor activity", "id": "GO:0008200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008200", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" }, { "id": "PF01299", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01299" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lysosome-associated membrane glycoprotein 2-like luminal", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 175, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFF4" }, { "id": "PF21222", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lysosome-associated membrane glycoprotein 2-like transmembrane", "eco_id": "ECO_0000259", "start_pos": 375, "end_pos": 406, "start_aa": "Ile", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 202 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 116, "end_pos": 118 }, { "start_pos": 125, "end_pos": 127 }, { "start_pos": 145, "end_pos": 147 }, { "start_pos": 160, "end_pos": 162 }, { "start_pos": 178, "end_pos": 180 }, { "start_pos": 214, "end_pos": 216 }, { "start_pos": 219, "end_pos": 221 }, { "start_pos": 232, "end_pos": 234 }, { "start_pos": 240, "end_pos": 242 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 313, "end_pos": 315 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 58, "end_pos": 60 }, { "start_pos": 71, "end_pos": 73 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZFN1-1", "uniprot_ac": "A0AAF6ZFN1", "uniprot_id": "A0AAF6ZFN1_BOVIN", "mass": { "chemical_mass": 22565.0, "monoisotopic_mass": 22565.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112443481", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1" } ] } ], "protein_names": [ { "name": "Cathelicidin 4", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112443481", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZFN1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZFN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10206:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10206:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00666", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00666", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQQQGLRQVHLRPWEEGRDGASQEDSWLNLCIRAQAEHKRRVLHLGGGRLGTMQTQRASLSLGRWSLWLLLLGLVVPSASAQALSYREAVLRAVDQLNELSSEANLYRLLELDPPPKDNEDLGTRKPVSFTVKETVCPRTIQQPAEQCDFKEKGRVKQCVGTVTLDPSNDQFDLNCNELQSVILPWKWPWWPWRRG", "length": 197, "header": "tr|A0AAF6ZFN1-1|A0AAF6ZFN1_BOVIN Isoform 1 of Cathelicidin 4 OS=Bos taurus OX=9913 GN=LOC112443481 PE=3 SV=1 CANONICAL=A0AAF6ZFN1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZFN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1/entry", "sequence": { "sequence": "MKQQQGLRQVHLRPWEEGRDGASQEDSWLNLCIRAQAEHKRRVLHLGGGRLGTMQTQRASLSLGRWSLWLLLLGLVVPSASAQALSYREAVLRAVDQLNELSSEANLYRLLELDPPPKDNEDLGTRKPVSFTVKETVCPRTIQQPAEQCDFKEKGRVKQCVGTVTLDPSNDQFDLNCNELQSVILPWKWPWWPWRRG", "length": 197, "header": "tr|A0AAF6ZFN1-1|A0AAF6ZFN1_BOVIN Isoform 1 of Cathelicidin 4 OS=Bos taurus OX=9913 GN=LOC112443481 PE=3 SV=1 CANONICAL=A0AAF6ZFN1-1" }, "locus": { "chromosome": "22", "start_pos": 51587643, "end_pos": 51586226, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044788.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044788.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042250.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042250.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZFV1-1", "uniprot_ac": "A0AAF6ZFV1", "uniprot_id": "A0AAF6ZFV1_BOVIN", "mass": { "chemical_mass": 24458.0, "monoisotopic_mass": 24458.0 }, "refseq": {}, "gene_names": [ { "name": "LYSET", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ] } ], "protein_names": [ { "name": "Lysosomal enzyme trafficking factor", "type": "recommended", "evidence": [ { "id": "A0AAF6ZFV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 251", "type": "synonym", "evidence": [ { "id": "A0AAF6ZFV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYSET", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1", "locus": { "chromosome": "21", "start_pos": 57813378, "end_pos": 57810490, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031885", "url": "https://www.ensembl.org/id/ENSBTAG00000031885" } ] } } ], "crossref": [ { "id": "A0AAF6ZFV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZFV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR028024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31925", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31925", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31925:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31925:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRASGPSRKPRVWQHPGRRAGGPTRTGGWPCSPFSQPVTPGDFFYGGFFSEMPKPPDYSELSDSLTLAVGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQHPEEPLEGTTWTHSLKTRLLSLPFWFWTVVFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT", "length": 214, "header": "tr|A0AAF6ZFV1-1|A0AAF6ZFV1_BOVIN Isoform 1 of Lysosomal enzyme trafficking factor OS=Bos taurus OX=9913 GN=LYSET PE=3 SV=1 CANONICAL=A0AAF6ZFV1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZFV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1/entry", "sequence": { "sequence": "MRASGPSRKPRVWQHPGRRAGGPTRTGGWPCSPFSQPVTPGDFFYGGFFSEMPKPPDYSELSDSLTLAVGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQHPEEPLEGTTWTHSLKTRLLSLPFWFWTVVFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT", "length": 214, "header": "tr|A0AAF6ZFV1-1|A0AAF6ZFV1_BOVIN Isoform 1 of Lysosomal enzyme trafficking factor OS=Bos taurus OX=9913 GN=LYSET PE=3 SV=1 CANONICAL=A0AAF6ZFV1-1" }, "locus": { "chromosome": "21", "start_pos": 57812071, "end_pos": 57810689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045223.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045223.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042633.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042633.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 39, "start_aa": "Thr", "end_pos": 39, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr39", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ], "pmid": "" }, { "name": "Golgi cisterna", "id": "GO:0031985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031985", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ], "pmid": "" }, { "name": "regulation of vesicle-mediated transport", "id": "GO:0060627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060627", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ], "pmid": "" }, { "name": "lysosomal transport", "id": "GO:0007041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007041", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 39 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZG02-1", "uniprot_ac": "A0AAF6ZG02", "uniprot_id": "A0AAF6ZG02_BOVIN", "mass": { "chemical_mass": 49424.0, "monoisotopic_mass": 49424.0 }, "refseq": { "ac": "XP_005208717", "name": "glutaryl-CoA dehydrogenase, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208717" }, "gene_names": [ { "name": "GCDH", "type": "recommended", "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ] }, { "name": "GCDH", "type": "synonym", "evidence": [ { "id": "XP_005208717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208717" } ] } ], "protein_names": [ { "name": "Glutaryl-CoA dehydrogenase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02/entry#names_and_taxonomy" } ] }, { "name": "1.3.8.6", "type": "synonym", "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02/entry#names_and_taxonomy" } ] }, { "name": "glutaryl-CoA dehydrogenase, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208717" } ] } ], "function": [ { "annotation": "Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02#function" }, { "database": "UniProtKB", "id": "ARBA00054820", "url": "https://www.uniprot.org/uniprotkb/ARBA00054820#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCDH", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02", "locus": { "chromosome": "7", "start_pos": 12657307, "end_pos": 12664100, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016211", "url": "https://www.ensembl.org/id/ENSBTAG00000016211" } ] } } ], "crossref": [ { "id": "A0AAF6ZG02", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZG02", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01151", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01151", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506310", "url": "https://www.ncbi.nlm.nih.gov/gene/506310", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42807", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42807", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42807:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42807:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02770", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02770", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208717", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208717", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13389", "url": "https://www.rhea-db.org/rhea/13389", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZG02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRGVYAQLLNRGPGLRVFRSWSSATAQTEKGEKTQSRSAKRKDPWLRPSRPEFDWRDPLLLEEQLTADEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGMLGPTIQGYSCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMYPIYAYGSEEQKQKYLPRLAKGELLGCFGLTEPNHGSDPSGMETRARHNPSSRSYILSGSKTWITNSPVADLLIVWARCEDSCIRGFLLEKGMRGLSTPRIEGKFSLRASSTGMIIMDDVEVPEENVLPGVSGLAGPFGCLNNARYGITWGVLGAAEFCLHTARQYTLDRIQFGVPLAKNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHVMNLESVNTYEGTHDIHALILGRAITGIQAFVAGK", "length": 445, "header": "tr|A0AAF6ZG02-1|A0AAF6ZG02_BOVIN Isoform 1 of Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=GCDH PE=3 SV=1 CANONICAL=A0AAF6ZG02-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZG02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02/entry", "sequence": { "sequence": "MALRGVYAQLLNRGPGLRVFRSWSSATAQTEKGEKTQSRSAKRKDPWLRPSRPEFDWRDPLLLEEQLTADEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGMLGPTIQGYSCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMYPIYAYGSEEQKQKYLPRLAKGELLGCFGLTEPNHGSDPSGMETRARHNPSSRSYILSGSKTWITNSPVADLLIVWARCEDSCIRGFLLEKGMRGLSTPRIEGKFSLRASSTGMIIMDDVEVPEENVLPGVSGLAGPFGCLNNARYGITWGVLGAAEFCLHTARQYTLDRIQFGVPLAKNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHVMNLESVNTYEGTHDIHALILGRAITGIQAFVAGK", "length": 445, "header": "tr|A0AAF6ZG02-1|A0AAF6ZG02_BOVIN Isoform 1 of Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=GCDH PE=3 SV=1 CANONICAL=A0AAF6ZG02-1" }, "locus": { "chromosome": "7", "start_pos": 12663922, "end_pos": 12657779, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045996.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045996.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043333.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043333.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glutaryl-CoA dehydrogenase activity", "id": "GO:0004361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004361", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "L-lysine catabolic process to acetyl-CoA via saccharopine", "id": "GO:0033512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033512", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation using acyl-CoA dehydrogenase", "id": "GO:0033539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033539", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "pmid": "" }, { "name": "L-lysine catabolic process to acetyl-CoA via L-pipecolate", "id": "GO:0033514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033514", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG02", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13389", "name": "", "equation": "glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZG02-1", "Q2KHZ9-1" ], "evidence": [ { "id": "13389", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13389" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZG02", "gene_name": "GCDH", "activity": [ { "ec_number": "1.3.8.6", "activity": "glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2.", "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ] }, { "ec_number": "1.3.8.6", "activity": "", "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" } ] } ] }, { "uniprot_ac": "Q2KHZ9", "gene_name": "GCDH", "activity": [ { "ec_number": "1.3.8.6", "activity": "glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2.", "evidence": [ { "id": "Q2KHZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ9" } ] }, { "ec_number": "1.3.8.6", "activity": "", "evidence": [ { "id": "Q2KHZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" }, { "id": "PF00441", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00441" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA dehydrogenase/oxidase C-terminal", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 435, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" }, { "id": "PF02771", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02771" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA dehydrogenase/oxidase N-terminal", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 179, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG02" }, { "id": "PF02770", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02770" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA oxidase/dehydrogenase middle", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 276, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.3.8.6", "ec_name": "glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2.", "evidence": [ { "id": "1.3.8.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.6" }, { "id": "1.3.8.6", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.8.6" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZG10-1", "uniprot_ac": "A0AAF6ZG10", "uniprot_id": "A0AAF6ZG10_BOVIN", "mass": { "chemical_mass": 30874.0, "monoisotopic_mass": 30874.0 }, "refseq": { "ac": "XP_005210131", "name": "ciliary microtubule inner protein 2B isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210131" }, "gene_names": [ { "name": "FAM166B", "type": "recommended", "evidence": [ { "id": "A0AAF6ZG10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10" } ] }, { "name": "CIMIP2B", "type": "synonym", "evidence": [ { "id": "XP_005210131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210131" } ] }, { "name": "FAM166B", "type": "synonym", "evidence": [ { "id": "XP_005210131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210131" } ] } ], "protein_names": [ { "name": "Ciliary microtubule inner protein 2B", "type": "recommended", "evidence": [ { "id": "A0AAF6ZG10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10/entry#names_and_taxonomy" } ] }, { "name": "ciliary microtubule inner protein 2B isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005210131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210131" } ] } ], "function": [ { "annotation": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10#function" }, { "database": "UniProtKB", "id": "ARBA00035003", "url": "https://www.uniprot.org/uniprotkb/ARBA00035003#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM166B", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZG10", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZG10", "database": "AlphaFoldDB", "categories": [] }, { "id": "507810", "url": "https://www.ncbi.nlm.nih.gov/gene/507810", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22146:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22146:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10629", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10629", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005210131", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210131", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZG10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZG10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTFIPGLNPQNPHYIPGYTGHCPLLRFSMGQTYGQMTGQLLRGSPGLAWPPAHRTLLPPIQPPRSPEPRRRSLPVRPGHERLSSSMVPGYTGSDTGFVPQAQFIFAKNCSQVWAEALNGFTQRNGGQGSQELPKEAKGEKDVEKDQEPKPEVEKEPELGQEAEQASPYSMDDRDPRKFFMSGFTGYVPRARFLFGSSFPVLSNQALQEFGEMKSPGRSQKDPKHLPALSRTYPQHLGLLPKYGGYVPGYKFQFGRTYGHLTQDALGLSTLQKQLLV", "length": 278, "header": "tr|A0AAF6ZG10-1|A0AAF6ZG10_BOVIN Isoform 1 of Ciliary microtubule inner protein 2B OS=Bos taurus OX=9913 GN=FAM166B PE=3 SV=1 CANONICAL=A0AAF6ZG10-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZG10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10/entry", "sequence": { "sequence": "MASTFIPGLNPQNPHYIPGYTGHCPLLRFSMGQTYGQMTGQLLRGSPGLAWPPAHRTLLPPIQPPRSPEPRRRSLPVRPGHERLSSSMVPGYTGSDTGFVPQAQFIFAKNCSQVWAEALNGFTQRNGGQGSQELPKEAKGEKDVEKDQEPKPEVEKEPELGQEAEQASPYSMDDRDPRKFFMSGFTGYVPRARFLFGSSFPVLSNQALQEFGEMKSPGRSQKDPKHLPALSRTYPQHLGLLPKYGGYVPGYKFQFGRTYGHLTQDALGLSTLQKQLLV", "length": 278, "header": "tr|A0AAF6ZG10-1|A0AAF6ZG10_BOVIN Isoform 1 of Ciliary microtubule inner protein 2B OS=Bos taurus OX=9913 GN=FAM166B PE=3 SV=1 CANONICAL=A0AAF6ZG10-1" }, "locus": { "chromosome": "8", "start_pos": 59787483, "end_pos": 59785618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046106.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046106.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043432.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043432.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "axonemal microtubule", "id": "GO:0005879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005879", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZG10", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZG10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZG10" }, { "id": "PF10629", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10629" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ciliary microtubule inner protein 2A-C-like", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 43, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGH9-1", "uniprot_ac": "A0AAF6ZGH9", "uniprot_id": "A0AAF6ZGH9_BOVIN", "mass": { "chemical_mass": 20804.0, "monoisotopic_mass": 20804.0 }, "refseq": {}, "gene_names": [ { "name": "DENR", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9" } ] } ], "protein_names": [ { "name": "Density-regulated protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENR", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9", "locus": { "chromosome": "29", "start_pos": 7664316, "end_pos": 7666635, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068852", "url": "https://www.ensembl.org/id/ENSBTAG00000068852" } ] } } ], "crossref": [ { "id": "A0AAF6ZGH9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11607", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11607", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12789", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12789", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12789:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12789:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZGH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQITHFESFTVESVHYQQSLFFSPLQYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 182, "header": "tr|A0AAF6ZGH9-1|A0AAF6ZGH9_BOVIN Isoform 1 of Density-regulated protein OS=Bos taurus OX=9913 GN=DENR PE=3 SV=1 CANONICAL=A0AAF6ZGH9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZGH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9/entry", "sequence": { "sequence": "MQITHFESFTVESVHYQQSLFFSPLQYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK", "length": 182, "header": "tr|A0AAF6ZGH9-1|A0AAF6ZGH9_BOVIN Isoform 1 of Density-regulated protein OS=Bos taurus OX=9913 GN=DENR PE=3 SV=1 CANONICAL=A0AAF6ZGH9-1" }, "locus": { "chromosome": "17", "start_pos": 52761130, "end_pos": 52750801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045998.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045998.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043335.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043335.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translational initiation", "id": "GO:0002183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002183", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGH9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZGH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGH9" }, { "id": "PS50296", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50296" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUI1", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 166, "start_aa": "Val", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGR2-1", "uniprot_ac": "A0AAF6ZGR2", "uniprot_id": "A0AAF6ZGR2_BOVIN", "mass": { "chemical_mass": 50534.0, "monoisotopic_mass": 50534.0 }, "refseq": {}, "gene_names": [ { "name": "SPATA2L", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2" } ] } ], "protein_names": [ { "name": "Spermatosis associated 2 like", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA2L", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2", "locus": { "chromosome": "18", "start_pos": 14575594, "end_pos": 14580423, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033334", "url": "https://www.ensembl.org/id/ENSBTAG00000033334" } ] } } ], "crossref": [ { "id": "A0AAF6ZGR2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGR2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR048839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15326", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15326", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15326:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15326:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZGR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZRU6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZRU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRARRGLSQVNSPAPEETPPRTSGPKPRGGAAPSGSALLPAEKPERSGWRLAPLGADSMGSSSLSEDYRLCLERELRRGRAGVCGDPSLRAVLWHILVEDFDLHGALQDDALALLTDGLWGRADLAPALRGLARAFELLELAAVHLYLLPWRKEFTTIKTFSGGYVHVLKGALSEDLLIQSFQKMGYVRRDAHRLMVAALPPARQLVQVALGCFALRLECEILGEVLAQLGTSVLPAEELLQARRASVDVASCVAWLQQRLAREEEPPPLPRRGSPTGCQARLDLYRDVQEDEGSDEASLYGGPSPGPDSPTSELACQPRFWEQSARLWGAGGGPWEPAEVSSPTSGASEEEEPQPEAFSFLSLRRELLSRPGDLAPPHAPRSPEQASPPPIPEPPGYQMHTCLAPGALPALCCDTCRQLHAAHCAALPSCHPGHSLRTLRGNSQRRLWLQRAQVDALLYDSPAAGP", "length": 467, "header": "tr|A0AAF6ZGR2-1|A0AAF6ZGR2_BOVIN Isoform 1 of Spermatosis associated 2 like OS=Bos taurus OX=9913 GN=SPATA2L PE=3 SV=1 CANONICAL=A0AAF6ZGR2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZGR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2/entry", "sequence": { "sequence": "MRARRGLSQVNSPAPEETPPRTSGPKPRGGAAPSGSALLPAEKPERSGWRLAPLGADSMGSSSLSEDYRLCLERELRRGRAGVCGDPSLRAVLWHILVEDFDLHGALQDDALALLTDGLWGRADLAPALRGLARAFELLELAAVHLYLLPWRKEFTTIKTFSGGYVHVLKGALSEDLLIQSFQKMGYVRRDAHRLMVAALPPARQLVQVALGCFALRLECEILGEVLAQLGTSVLPAEELLQARRASVDVASCVAWLQQRLAREEEPPPLPRRGSPTGCQARLDLYRDVQEDEGSDEASLYGGPSPGPDSPTSELACQPRFWEQSARLWGAGGGPWEPAEVSSPTSGASEEEEPQPEAFSFLSLRRELLSRPGDLAPPHAPRSPEQASPPPIPEPPGYQMHTCLAPGALPALCCDTCRQLHAAHCAALPSCHPGHSLRTLRGNSQRRLWLQRAQVDALLYDSPAAGP", "length": 467, "header": "tr|A0AAF6ZGR2-1|A0AAF6ZGR2_BOVIN Isoform 1 of Spermatosis associated 2 like OS=Bos taurus OX=9913 GN=SPATA2L PE=3 SV=1 CANONICAL=A0AAF6ZGR2-1" }, "locus": { "chromosome": "18", "start_pos": 14580111, "end_pos": 14576041, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047408.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047408.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044617.2", "url": "https://www.ensembl.org/id/ENSBTAP00000044617.2" } ] } }, { "isoform_ac": "A0AAF6ZRU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRU6/entry", "sequence": { "sequence": "MHLEVCEVRCPFRVDASPEGAESSKHMGSSSLSEDYRLCLERELRRGRAGVCGDPSLRAVLWHILVEDFDLHGALQDDALALLTDGLWGRADLAPALRGLARAFELLELAAVHLYLLPWRKEFTTIKTFSGGYVHVLKGALSEDLLIQSFQKMGYVRRDAHRLMVAALPPARQLVQVALGCFALRLECEILGEVLAQLGTSVLPAEELLQARRASVDVASCVAWLQQRLAREEEPPPLPRRGSPTGCQARLDLYRDVQEDEGSDEASLYGGPSPGPDSPTSELACQPRFWEQSARLWGAGGGPWEPAEVSSPTSGASEEEEPQPEAFSFLSLRRELLSRPGDLAPPHAPRSPEQASPPPIPEPPGYQMHTCLAPGALPALCCDTCRQLHAAHCAALPSCHPGHSLRTLRGNSQRRLWLQRAQVDALLYDSPAAGP", "length": 435, "header": "tr|A0AAF6ZRU6-1|A0AAF6ZRU6_BOVIN Computationally mapped isoform of Spermatosis associated 2 like OS=Bos taurus OX=9913 GN=SPATA2L PE=3 SV=1 CANONICAL=A0AAF6ZGR2-1" }, "locus": { "chromosome": "18", "start_pos": 14580154, "end_pos": 14576041, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074595.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074595.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056772.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056772.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZGR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGR2" }, { "id": "PF21388", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21388" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spermatogenesis-associated protein 2 PUB-like", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 253, "start_aa": "Ala", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGS1-1", "uniprot_ac": "A0AAF6ZGS1", "uniprot_id": "A0AAF6ZGS1_BOVIN", "mass": { "chemical_mass": 39245.0, "monoisotopic_mass": 39245.0 }, "refseq": {}, "gene_names": [ { "name": "STAR", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" } ] } ], "protein_names": [ { "name": "Steroidogenic acute regulatory protein, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1/entry#names_and_taxonomy" } ] }, { "name": "START domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1/entry#names_and_taxonomy" } ] }, { "name": "StAR", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1#function" }, { "database": "UniProtKB", "id": "RU365007", "url": "https://www.uniprot.org/uniprotkb/RU365007#function" }, { "database": "UniProtKB", "id": "ARBA00060302", "url": "https://www.uniprot.org/uniprotkb/ARBA00060302#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STAR", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1", "locus": { "chromosome": "27", "start_pos": 33312972, "end_pos": 33321495, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033345", "url": "https://www.ensembl.org/id/ENSBTAG00000033345" } ] } } ], "crossref": [ { "id": "A0AAF6ZGS1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08905", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08905", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46489:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46489:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "39747", "url": "https://www.rhea-db.org/rhea/39747", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMKHSLQLEVFKAQKHIIWPQLQGPRPQPCQAEEAQEQPSSGTRGHSRSPQHPRQTPHLPLLPGKMLLATFKLCAGSSYRHVRSMKGLQQQAVLAIGQELNRRALGGPAPAAWINQVRRRGSLLGSQLEDPLYSDQELAYIQQGEEAMQRALGILKDQEGWKKESRQANGDEVLSKVIPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAEVAGNLVGPRDFVSVRCTKRRGSMCVLAGMATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC", "length": 350, "header": "tr|A0AAF6ZGS1-1|A0AAF6ZGS1_BOVIN Isoform 1 of Steroidogenic acute regulatory protein, mitochondrial OS=Bos taurus OX=9913 GN=STAR PE=4 SV=1 CANONICAL=A0AAF6ZGS1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZGS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1/entry", "sequence": { "sequence": "MMKHSLQLEVFKAQKHIIWPQLQGPRPQPCQAEEAQEQPSSGTRGHSRSPQHPRQTPHLPLLPGKMLLATFKLCAGSSYRHVRSMKGLQQQAVLAIGQELNRRALGGPAPAAWINQVRRRGSLLGSQLEDPLYSDQELAYIQQGEEAMQRALGILKDQEGWKKESRQANGDEVLSKVIPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAEVAGNLVGPRDFVSVRCTKRRGSMCVLAGMATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC", "length": 350, "header": "tr|A0AAF6ZGS1-1|A0AAF6ZGS1_BOVIN Isoform 1 of Steroidogenic acute regulatory protein, mitochondrial OS=Bos taurus OX=9913 GN=STAR PE=4 SV=1 CANONICAL=A0AAF6ZGS1-1" }, "locus": { "chromosome": "27", "start_pos": 33320456, "end_pos": 33314708, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047426.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047426.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044633.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044633.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" } ], "pmid": "" }, { "name": "cholesterol transfer activity", "id": "GO:0120020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39747", "name": "", "equation": "cholesterol(in) = cholesterol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "39747", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39747" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZGS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGS1" }, { "id": "PS50848", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "START", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 345, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGV0-1", "uniprot_ac": "A0AAF6ZGV0", "uniprot_id": "A0AAF6ZGV0_BOVIN", "mass": { "chemical_mass": 65772.0, "monoisotopic_mass": 65772.0 }, "refseq": {}, "gene_names": [ { "name": "CFAP210", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0" } ] } ], "protein_names": [ { "name": "Cilia and flagella associated protein 210", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGV0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP210", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0", "locus": { "chromosome": "2", "start_pos": 26643283, "end_pos": 26618858, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001090", "url": "https://www.ensembl.org/id/ENSBTAG00000001090" } ] } } ], "crossref": [ { "id": "A0AAF6ZGV0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR039986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28663:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28663:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13868", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13868", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZGV0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AGTLEMLVRFGRRSGQAKESAEMKNCEEDPVLYPPLLPTKVDLRQVTIIPHNEWERIRDSLDSLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDIEEAIYKQGERKKAIELAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFQKSKIKSDKKWEEQVKLNVEKAFKEEREKAEKQRRERVALAKDHLKQIKEHEEEEERRRKEEEKDAEEIKRQNSLYEIEMKKKQGKKKEEINESRRLFFEHLNDKHIIKAVEQQQQEEEDEKIRKFIKAKKRLTQMGKEKEAETHRLMEERRKRINNFLSKLMKEKFDNEDLIIARDIAEAEAEWEKREREKYEKNKAELKAIAEHRALVMKNKEEEERQRKIEATEQMLAILKADQIFWEHEKEKKQKADKERREVQDAHIQQMAKHKFNALQAKQAESEYCRLTEALVAEKEKEFQDYAREVIESESESTKKYIYPLVKAVQEGPGGGRGPVLVDRGGLRPSYQANDTTGVQLPFYNSPGSKYNNFQKSKGRLGFTW", "length": 552, "header": "tr|A0AAF6ZGV0-1|A0AAF6ZGV0_BOVIN Isoform 1 of Cilia and flagella associated protein 210 OS=Bos taurus OX=9913 GN=CFAP210 PE=4 SV=1 CANONICAL=A0AAF6ZGV0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZGV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0/entry", "sequence": { "sequence": "AGTLEMLVRFGRRSGQAKESAEMKNCEEDPVLYPPLLPTKVDLRQVTIIPHNEWERIRDSLDSLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDIEEAIYKQGERKKAIELAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFQKSKIKSDKKWEEQVKLNVEKAFKEEREKAEKQRRERVALAKDHLKQIKEHEEEEERRRKEEEKDAEEIKRQNSLYEIEMKKKQGKKKEEINESRRLFFEHLNDKHIIKAVEQQQQEEEDEKIRKFIKAKKRLTQMGKEKEAETHRLMEERRKRINNFLSKLMKEKFDNEDLIIARDIAEAEAEWEKREREKYEKNKAELKAIAEHRALVMKNKEEEERQRKIEATEQMLAILKADQIFWEHEKEKKQKADKERREVQDAHIQQMAKHKFNALQAKQAESEYCRLTEALVAEKEKEFQDYAREVIESESESTKKYIYPLVKAVQEGPGGGRGPVLVDRGGLRPSYQANDTTGVQLPFYNSPGSKYNNFQKSKGRLGFTW", "length": 552, "header": "tr|A0AAF6ZGV0-1|A0AAF6ZGV0_BOVIN Isoform 1 of Cilia and flagella associated protein 210 OS=Bos taurus OX=9913 GN=CFAP210 PE=4 SV=1 CANONICAL=A0AAF6ZGV0-1" }, "locus": { "chromosome": "2", "start_pos": 26643165, "end_pos": 26618935, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046952.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046952.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044199.5", "url": "https://www.ensembl.org/id/ENSBTAP00000044199.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGV0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGV0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0" } ], "pmid": "" }, { "name": "axonemal B tubule inner sheath", "id": "GO:0160112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160112", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGV0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZGV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGV0" }, { "id": "PF13868", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13868" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Trichohyalin-plectin-homology", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 488, "start_aa": "Gln", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 }, { "start_pos": 521, "end_pos": 523 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZGY2-1", "uniprot_ac": "A0AAF6ZGY2", "uniprot_id": "A0AAF6ZGY2_BOVIN", "mass": { "chemical_mass": 27305.0, "monoisotopic_mass": 27305.0 }, "refseq": {}, "gene_names": [ { "name": "IFI30", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2" } ] } ], "protein_names": [ { "name": "Gamma-interferon-inducible lysosomal thiol reductase", "type": "recommended", "evidence": [ { "id": "A0AAF6ZGY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2/entry#names_and_taxonomy" } ] }, { "name": "1.8.-.-", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2/entry#names_and_taxonomy" } ] }, { "name": "Gamma-interferon-inducible protein IP-30", "type": "synonym", "evidence": [ { "id": "A0AAF6ZGY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Lysosomal thiol reductase that can reduce protein disulfide bonds. Facilitates the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2#function" }, { "database": "UniProtKB", "id": "RU369109", "url": "https://www.uniprot.org/uniprotkb/RU369109#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFI30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2", "locus": { "chromosome": "7", "start_pos": 5054636, "end_pos": 5058251, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018349", "url": "https://www.ensembl.org/id/ENSBTAG00000018349" } ] } } ], "crossref": [ { "id": "A0AAF6ZGY2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZGY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSPLLFVLLLLLPLEVPAATRWSLLEALPEGAAPCQVGELCLQASPQKPDVPLVNVSLYYEALCPGCREFLIRELFPTWLMVLEILNVTLVPYGNAQERNVSGKWEFTCQHGERECLLNKVEACLLDQLEQKIAFLTIVCLEEMDDMEQNLKPCLQIYAPKVSADSIMECATGNRGMQLLHINAQLTDALRPPHKYVPWVVVNGEHMKDAEHLLHLVCRLYQKPDVCQLTAELSKEVHFK", "length": 242, "header": "tr|A0AAF6ZGY2-1|A0AAF6ZGY2_BOVIN Isoform 1 of Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus OX=9913 GN=IFI30 PE=3 SV=1 CANONICAL=A0AAF6ZGY2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZGY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2/entry", "sequence": { "sequence": "MASSPLLFVLLLLLPLEVPAATRWSLLEALPEGAAPCQVGELCLQASPQKPDVPLVNVSLYYEALCPGCREFLIRELFPTWLMVLEILNVTLVPYGNAQERNVSGKWEFTCQHGERECLLNKVEACLLDQLEQKIAFLTIVCLEEMDDMEQNLKPCLQIYAPKVSADSIMECATGNRGMQLLHINAQLTDALRPPHKYVPWVVVNGEHMKDAEHLLHLVCRLYQKPDVCQLTAELSKEVHFK", "length": 242, "header": "tr|A0AAF6ZGY2-1|A0AAF6ZGY2_BOVIN Isoform 1 of Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus OX=9913 GN=IFI30 PE=3 SV=1 CANONICAL=A0AAF6ZGY2-1" }, "locus": { "chromosome": "7", "start_pos": 5058228, "end_pos": 5055116, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047907.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047907.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045061.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045061.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "antigen processing and presentation of exogenous peptide antigen via MHC class I", "id": "GO:0042590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042590", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "id": "GO:0016671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016671", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGY2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZH14-1", "uniprot_ac": "A0AAF6ZH14", "uniprot_id": "A0AAF6ZH14_BOVIN", "mass": { "chemical_mass": 36314.0, "monoisotopic_mass": 36314.0 }, "refseq": {}, "gene_names": [ { "name": "RRP36", "type": "recommended", "evidence": [ { "id": "A0AAF6ZH14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ] } ], "protein_names": [ { "name": "rRNA biogenesis protein RRP36", "type": "recommended", "evidence": [ { "id": "A0AAF6ZH14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14#function" }, { "database": "UniProtKB", "id": "RU368027", "url": "https://www.uniprot.org/uniprotkb/RU368027#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RRP36", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14", "locus": { "chromosome": "23", "start_pos": 16665996, "end_pos": 16661300, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053873", "url": "https://www.ensembl.org/id/ENSBTAG00000053873" } ] } } ], "crossref": [ { "id": "A0AAF6ZH14", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZH14", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR009292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21738:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21738:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZH14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGTPAAHQQPAGSRLRCRRQAFRKGRGGSPCGGSNAISFLYTAEAMRRASSCGGAVAGSPSEAQDGGEDDGSLRNDTSHMSFEELLELQSQVGTKAYKQLVTGSSTKKQSSRPPVQKGCVADKHRPLEMSAKVRVPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLDDIRAREKELVKKQLKKHRSGEEHEKLQHLLQRMVSRSEYGVGGDSQSLLFTCLTPLISAPQEQQEMAQKERKRQQELRLALKQERRAQAQQGHRPYFLKKSEQRQLVLAEKFKELKRSKKLESFLSRKRRRNAGKDRRHLPLSKE", "length": 320, "header": "tr|A0AAF6ZH14-1|A0AAF6ZH14_BOVIN Isoform 1 of rRNA biogenesis protein RRP36 OS=Bos taurus OX=9913 GN=RRP36 PE=3 SV=1 CANONICAL=A0AAF6ZH14-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZH14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14/entry", "sequence": { "sequence": "MEGTPAAHQQPAGSRLRCRRQAFRKGRGGSPCGGSNAISFLYTAEAMRRASSCGGAVAGSPSEAQDGGEDDGSLRNDTSHMSFEELLELQSQVGTKAYKQLVTGSSTKKQSSRPPVQKGCVADKHRPLEMSAKVRVPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLDDIRAREKELVKKQLKKHRSGEEHEKLQHLLQRMVSRSEYGVGGDSQSLLFTCLTPLISAPQEQQEMAQKERKRQQELRLALKQERRAQAQQGHRPYFLKKSEQRQLVLAEKFKELKRSKKLESFLSRKRRRNAGKDRRHLPLSKE", "length": 320, "header": "tr|A0AAF6ZH14-1|A0AAF6ZH14_BOVIN Isoform 1 of rRNA biogenesis protein RRP36 OS=Bos taurus OX=9913 GN=RRP36 PE=3 SV=1 CANONICAL=A0AAF6ZH14-1" }, "locus": { "chromosome": "23", "start_pos": 16665210, "end_pos": 16661499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047039.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047039.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044278.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044278.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH14", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH14" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZH32-1", "uniprot_ac": "A0AAF6ZH32", "uniprot_id": "A0AAF6ZH32_BOVIN", "mass": { "chemical_mass": 44058.0, "monoisotopic_mass": 44058.0 }, "refseq": {}, "gene_names": [ { "name": "BABAM1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZH32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ] } ], "protein_names": [ { "name": "BRISC and BRCA1-A complex member 1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZH32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32/entry#names_and_taxonomy" } ] }, { "name": "Mediator of RAP80 interactions and targeting subunit of 40 kDa", "type": "synonym", "evidence": [ { "id": "A0AAF6ZH32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32/entry#names_and_taxonomy" } ] }, { "name": "New component of the BRCA1-A complex", "type": "synonym", "evidence": [ { "id": "A0AAF6ZH32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BABAM1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32", "locus": { "chromosome": "7", "start_pos": 5837522, "end_pos": 5843496, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012587", "url": "https://www.ensembl.org/id/ENSBTAG00000012587" } ] } } ], "crossref": [ { "id": "A0AAF6ZH32", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZH32", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21502", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21502", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR026126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15660", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15660", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15660:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15660:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZH32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZVS7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZVS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZVS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZVS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRKEAQATTFSVSGDRTPNSVWLKQERKFRHSWIRALRSFSFSGPRERILASLIPAASSHSGAMEVAEPSCPTEEEEEEEEEEEQSAEPRPRTRSNPEGAEDRALGAQTSVGSRSEGEGEAASADDGTANPPGAGPKPWQVPPPAPEVQVRTPRVNCPEKVIICLDLSEEMALPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDVVYIHNGADEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLAHPLQRPCQSHASYSLLEEDDEATEVEATV", "length": 396, "header": "tr|A0AAF6ZH32-1|A0AAF6ZH32_BOVIN Isoform 1 of BRISC and BRCA1-A complex member 1 OS=Bos taurus OX=9913 GN=BABAM1 PE=3 SV=1 CANONICAL=A0AAF6ZH32-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZH32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32/entry", "sequence": { "sequence": "MSRKEAQATTFSVSGDRTPNSVWLKQERKFRHSWIRALRSFSFSGPRERILASLIPAASSHSGAMEVAEPSCPTEEEEEEEEEEEQSAEPRPRTRSNPEGAEDRALGAQTSVGSRSEGEGEAASADDGTANPPGAGPKPWQVPPPAPEVQVRTPRVNCPEKVIICLDLSEEMALPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDVVYIHNGADEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLAHPLQRPCQSHASYSLLEEDDEATEVEATV", "length": 396, "header": "tr|A0AAF6ZH32-1|A0AAF6ZH32_BOVIN Isoform 1 of BRISC and BRCA1-A complex member 1 OS=Bos taurus OX=9913 GN=BABAM1 PE=3 SV=1 CANONICAL=A0AAF6ZH32-1" }, "locus": { "chromosome": "7", "start_pos": 5843337, "end_pos": 5837803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047445.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047445.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044652.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044652.3" } ] } }, { "isoform_ac": "A0AAF6ZVS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZVS7/entry", "sequence": { "sequence": "MEVAEPSCPTEEEEEEEEEEEQSAEPRPRTRSNPEGAEDRALGAQTSVGSRSEGEGEAASADDGTANPPGAGPKPWQVPPPAPEVQVRTPRVNCPEKVIICLDLSEEMALPKLESFNGQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDVVYIHNGADEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLAHPLQRPCQSHASYSLLEEDDEATEVEATV", "length": 257, "header": "tr|A0AAF6ZVS7-1|A0AAF6ZVS7_BOVIN Computationally mapped isoform of BRISC and BRCA1 A complex member 1 OS=Bos taurus OX=9913 GN=BABAM1 PE=4 SV=1 CANONICAL=A0AAF6ZH32-1" }, "locus": { "chromosome": "7", "start_pos": 5842407, "end_pos": 5837803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077592.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077592.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058698.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058698.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "BRISC complex", "id": "GO:0070552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070552", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "BRCA1-A complex", "id": "GO:0070531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070531", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "response to ionizing radiation", "id": "GO:0010212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "DNA repair-dependent chromatin remodeling", "id": "GO:0140861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140861", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZH32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 181, "end_pos": 183 }, { "start_pos": 189, "end_pos": 191 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZHF1-1", "uniprot_ac": "A0AAF6ZHF1", "uniprot_id": "A0AAF6ZHF1_BOVIN", "mass": { "chemical_mass": 36312.0, "monoisotopic_mass": 36312.0 }, "refseq": {}, "gene_names": [ { "name": "UBTD2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZHF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1" } ] } ], "protein_names": [ { "name": "Ubiquitin domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAF6ZHF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBTD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1", "locus": { "chromosome": "20", "start_pos": 3997791, "end_pos": 4064147, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034659", "url": "https://www.ensembl.org/id/ENSBTAG00000034659" } ] } } ], "crossref": [ { "id": "A0AAF6ZHF1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZHF1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZHF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRAVPWGGGRWGLTDAGLRRGARLHAGARGCEGVRWAPRPARDGPAPAWRGRAGGWAAAGERSGALVRSSAAAAPEEAEAAAGPDERPEVADEAPGAPMGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYESQLRLRLSTGKDLKLVVRSTDTVYHMKRRLHAAEGVEPASQRWFFSGRPLTDKMRLEELKIPKDYVVQVIMSQPLQNPTPVEN", "length": 333, "header": "tr|A0AAF6ZHF1-1|A0AAF6ZHF1_BOVIN Isoform 1 of Ubiquitin domain containing 2 OS=Bos taurus OX=9913 GN=UBTD2 PE=4 SV=1 CANONICAL=A0AAF6ZHF1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZHF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1/entry", "sequence": { "sequence": "MRRAVPWGGGRWGLTDAGLRRGARLHAGARGCEGVRWAPRPARDGPAPAWRGRAGGWAAAGERSGALVRSSAAAAPEEAEAAAGPDERPEVADEAPGAPMGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGYESQLRLRLSTGKDLKLVVRSTDTVYHMKRRLHAAEGVEPASQRWFFSGRPLTDKMRLEELKIPKDYVVQVIMSQPLQNPTPVEN", "length": 333, "header": "tr|A0AAF6ZHF1-1|A0AAF6ZHF1_BOVIN Isoform 1 of Ubiquitin domain containing 2 OS=Bos taurus OX=9913 GN=UBTD2 PE=4 SV=1 CANONICAL=A0AAF6ZHF1-1" }, "locus": { "chromosome": "20", "start_pos": 4063999, "end_pos": 3997987, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049094.3", "url": "https://www.ensembl.org/id/ENSBTAT00000049094.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046032.2", "url": "https://www.ensembl.org/id/ENSBTAP00000046032.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZHF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHF1" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 251, "end_pos": 324, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZIE2-1", "uniprot_ac": "A0AAF6ZIE2", "uniprot_id": "A0AAF6ZIE2_BOVIN", "mass": { "chemical_mass": 35792.0, "monoisotopic_mass": 35792.0 }, "refseq": { "ac": "XP_005224585", "name": "target of rapamycin complex subunit LST8 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224585" }, "gene_names": [ { "name": "MLST8", "type": "recommended", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ] }, { "name": "GBL", "type": "synonym", "evidence": [ { "id": "XP_005224585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224585" } ] }, { "name": "MLST8", "type": "synonym", "evidence": [ { "id": "XP_005224585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224585" } ] } ], "protein_names": [ { "name": "Target of rapamycin complex subunit LST8", "type": "recommended", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry#names_and_taxonomy" } ] }, { "name": "G protein beta subunit-like", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry#names_and_taxonomy" } ] }, { "name": "Mammalian lethal with SEC13 protein 8", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry#names_and_taxonomy" } ] }, { "name": "Protein GbetaL", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry#names_and_taxonomy" } ] }, { "name": "TORC subunit LST8", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry#names_and_taxonomy" } ] }, { "name": "mLST8", "type": "synonym", "evidence": [ { "id": "A0AAF6ZIE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry#names_and_taxonomy" } ] }, { "name": "target of rapamycin complex subunit LST8 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005224585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224585" } ] } ], "function": [ { "annotation": "Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy. The mTORC1 complex is inhibited in response to starvation and amino acid depletion. Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2#function" }, { "database": "UniProtKB", "id": "RU369068", "url": "https://www.uniprot.org/uniprotkb/RU369068#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MLST8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2", "locus": { "chromosome": "25", "start_pos": 1740141, "end_pos": 1736239, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009928", "url": "https://www.ensembl.org/id/ENSBTAG00000009928" } ] } } ], "crossref": [ { "id": "A0AAF6ZIE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZIE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535236", "url": "https://www.ncbi.nlm.nih.gov/gene/535236", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19842:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19842:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224585", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224585", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZIE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEITPDRTMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNVASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSSNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG", "length": 325, "header": "tr|A0AAF6ZIE2-1|A0AAF6ZIE2_BOVIN Isoform 1 of Target of rapamycin complex subunit LST8 OS=Bos taurus OX=9913 GN=MLST8 PE=3 SV=1 CANONICAL=A0AAF6ZIE2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZIE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2/entry", "sequence": { "sequence": "MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEITPDRTMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNVASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSSNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG", "length": 325, "header": "tr|A0AAF6ZIE2-1|A0AAF6ZIE2_BOVIN Isoform 1 of Target of rapamycin complex subunit LST8 OS=Bos taurus OX=9913 GN=MLST8 PE=3 SV=1 CANONICAL=A0AAF6ZIE2-1" }, "locus": { "chromosome": "25", "start_pos": 1739667, "end_pos": 1736940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053181.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053181.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048491.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048491.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "positive regulation of TOR signaling", "id": "GO:0032008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032008", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "TORC1 signaling", "id": "GO:0038202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038202", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "TORC2 signaling", "id": "GO:0038203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038203", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "TORC1 complex", "id": "GO:0031931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031931", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" }, { "name": "TORC2 complex", "id": "GO:0031932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031932", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZIE2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 197, "end_pos": 199 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 320, "end_pos": 322 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZJ25-1", "uniprot_ac": "A0AAF6ZJ25", "uniprot_id": "A0AAF6ZJ25_BOVIN", "mass": { "chemical_mass": 21847.0, "monoisotopic_mass": 21847.0 }, "refseq": {}, "gene_names": [ { "name": "NUDT16", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] } ], "protein_names": [ { "name": "U8 snoRNA-decapping enzyme", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.64", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry#names_and_taxonomy" } ] }, { "name": "IDP phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry#names_and_taxonomy" } ] }, { "name": "Inosine diphosphate phosphatase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry#names_and_taxonomy" } ] }, { "name": "Nucleoside diphosphate-linked moiety X motif 16", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry#names_and_taxonomy" } ] }, { "name": "m7GpppN-mRNA hydrolase", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25", "locus": { "chromosome": "1", "start_pos": 138548022, "end_pos": 138550417, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018749", "url": "https://www.ensembl.org/id/ENSBTAG00000018749" } ] } } ], "crossref": [ { "id": "A0AAF6ZJ25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZJ25", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31699", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31699", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31699:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31699:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "35207", "url": "https://www.rhea-db.org/rhea/35207", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "35211", "url": "https://www.rhea-db.org/rhea/35211", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67484", "url": "https://www.rhea-db.org/rhea/67484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGMRRLELSEALHLGPGWRHACHALLYAPDPGLLFGRIPLRYAVLMQMRFDGRLGFPGGFVDLRDGSLEDGLNRELGEELGEAAGAFRVERADYRSSHAGSRPRVVAHFYTKLLTLEQLTAVEMGAPRARDHGLEVGPAQDPTPPPPAPEGAGPGAGAPVYPAGWCGRPACLPGEYLYWKCTGTAAGSRPEPGTAGTWLFCTP", "length": 204, "header": "tr|A0AAF6ZJ25-1|A0AAF6ZJ25_BOVIN Isoform 1 of U8 snoRNA-decapping enzyme OS=Bos taurus OX=9913 GN=NUDT16 PE=3 SV=1 CANONICAL=A0AAF6ZJ25-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZJ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25/entry", "sequence": { "sequence": "MAGMRRLELSEALHLGPGWRHACHALLYAPDPGLLFGRIPLRYAVLMQMRFDGRLGFPGGFVDLRDGSLEDGLNRELGEELGEAAGAFRVERADYRSSHAGSRPRVVAHFYTKLLTLEQLTAVEMGAPRARDHGLEVGPAQDPTPPPPAPEGAGPGAGAPVYPAGWCGRPACLPGEYLYWKCTGTAAGSRPEPGTAGTWLFCTP", "length": 204, "header": "tr|A0AAF6ZJ25-1|A0AAF6ZJ25_BOVIN Isoform 1 of U8 snoRNA-decapping enzyme OS=Bos taurus OX=9913 GN=NUDT16 PE=3 SV=1 CANONICAL=A0AAF6ZJ25-1" }, "locus": { "chromosome": "1", "start_pos": 138550397, "end_pos": 138549026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053197.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053197.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049112.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049112.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 144, "start_aa": "Thr", "end_pos": 144, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr144", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "chloride ion binding", "id": "GO:0031404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031404", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "snoRNA binding", "id": "GO:0030515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030515", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "metalloexopeptidase activity", "id": "GO:0008235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008235", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "cobalt ion binding", "id": "GO:0050897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "phosphodiesterase decapping endonuclease activity", "id": "GO:1990174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990174", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "IDP phosphatase activity", "id": "GO:1990003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990003", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "id": "GO:0140933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140933", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nucleotide metabolic process", "id": "GO:0009117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009117", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "mRNA catabolic process", "id": "GO:0006402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006402", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "sno(s)RNA catabolic process", "id": "GO:0016077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016077", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "positive regulation of cell cycle process", "id": "GO:0090068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090068", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" }, { "name": "NAD-cap decapping", "id": "GO:0110155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110155", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "35207", "name": "", "equation": "IDP + H2O = IMP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZJ25-1", "F1MB25-1", "A1A4Q9-1", "E1BPW0-1", "O18956-1", "G5E5P3-1" ], "evidence": [ { "id": "35207", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35207" } ] }, { "id": "35211", "name": "", "equation": "dIDP + H2O = dIMP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZJ25-1", "A1A4Q9-1" ], "evidence": [ { "id": "35211", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35211" } ] }, { "id": "67484", "name": "", "equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N4I7-1", "F1MLY3-1", "A0AAF6ZJ25-1", "A1A4Q9-1", "A2VE79-1", "Q3SZL6-1", "A4FUG7-1", "A0AAA9SRY7-1", "A0AAA9TYZ1-1" ], "evidence": [ { "id": "67484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67484" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SRY7", "gene_name": "DCP2", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] } ] }, { "uniprot_ac": "A0AAA9TYZ1", "gene_name": "NUDT17", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A0AAA9TYZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ1" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A0AAA9TYZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ1" } ] } ] }, { "uniprot_ac": "A0AAF6ZJ25", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] }, { "ec_number": "3.6.1.64", "activity": "", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] } ] }, { "uniprot_ac": "A1A4Q9", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] } ] }, { "uniprot_ac": "A2VE79", "gene_name": "NUDT3", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.52", "activity": "6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.10", "activity": "[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.61", "activity": "P(1),P(6)-bis(5'-adenosyl) hexaphosphate + H2O = 2 ATP + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.52", "activity": "", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] } ] }, { "uniprot_ac": "A4FUG7", "gene_name": "NUDT17", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A4FUG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUG7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A4FUG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUG7" } ] } ] }, { "uniprot_ac": "E1BPW0", "gene_name": "ENTPD5", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "E1BPW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPW0" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "E1BPW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPW0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MLY3", "gene_name": "DCP1B", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "F1MLY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY3" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "F1MLY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY3" } ] } ] }, { "uniprot_ac": "F1N4I7", "gene_name": "DCP1A", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] } ] }, { "uniprot_ac": "G5E5P3", "gene_name": "ENTPD5", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "G5E5P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5P3" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "G5E5P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5P3" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "Q3SZL6", "gene_name": "DCP1B", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 155, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.64", "ec_name": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "3.6.1.64", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64" }, { "id": "3.6.1.64", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.64" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 144 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZJK8-1", "uniprot_ac": "A0AAF6ZJK8", "uniprot_id": "A0AAF6ZJK8_BOVIN", "mass": { "chemical_mass": 45443.0, "monoisotopic_mass": 45443.0 }, "refseq": {}, "gene_names": [ { "name": "MRPL38", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL38", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L38, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8", "locus": { "chromosome": "19", "start_pos": 55726175, "end_pos": 55721633, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022009", "url": "https://www.ensembl.org/id/ENSBTAG00000022009" } ] } } ], "crossref": [ { "id": "A0AAF6ZJK8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZJK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00866", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00866", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR008914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11362", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11362", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11362:SF133", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11362:SF133", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZJK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPWWRVVLNGSRNWRGFSTSAALSRRAAPLGPMPNEDIDVSNLERLKKYRSFDRYRRRAEREARDPHWWRTYREHFGEESDPKDTVDIGLPPPKVCRTQQLLERKRVLRELRTSVEEERASRLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAIGEDDLVPVYYGNEVTPTEAAQPPEVTYEADEGSMWTLLLTNLVSGVYLCVDGHLLEPDAEYVHWLVTNIPGSRVAEGEETCPYLPPFPARGSGFHRFAFLLFKQDKPVDFSGDTRPSPCYQLAQRTFHTFDFYKKHQDAMTPAGLAFFQCRWDDSVTHIFHQLLDMREPVFEFVRPPPYHPKQKCFPHRQPLRYLDRYRDSHEPTYGFY", "length": 388, "header": "tr|A0AAF6ZJK8-1|A0AAF6ZJK8_BOVIN Isoform 1 of Large ribosomal subunit protein mL38 OS=Bos taurus OX=9913 GN=MRPL38 PE=3 SV=1 CANONICAL=A0AAF6ZJK8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZJK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8/entry", "sequence": { "sequence": "MAAPWWRVVLNGSRNWRGFSTSAALSRRAAPLGPMPNEDIDVSNLERLKKYRSFDRYRRRAEREARDPHWWRTYREHFGEESDPKDTVDIGLPPPKVCRTQQLLERKRVLRELRTSVEEERASRLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAIGEDDLVPVYYGNEVTPTEAAQPPEVTYEADEGSMWTLLLTNLVSGVYLCVDGHLLEPDAEYVHWLVTNIPGSRVAEGEETCPYLPPFPARGSGFHRFAFLLFKQDKPVDFSGDTRPSPCYQLAQRTFHTFDFYKKHQDAMTPAGLAFFQCRWDDSVTHIFHQLLDMREPVFEFVRPPPYHPKQKCFPHRQPLRYLDRYRDSHEPTYGFY", "length": 388, "header": "tr|A0AAF6ZJK8-1|A0AAF6ZJK8_BOVIN Isoform 1 of Large ribosomal subunit protein mL38 OS=Bos taurus OX=9913 GN=MRPL38 PE=3 SV=1 CANONICAL=A0AAF6ZJK8-1" }, "locus": { "chromosome": "19", "start_pos": 55725970, "end_pos": 55721661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052019.5", "url": "https://www.ensembl.org/id/ENSBTAT00000052019.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050302.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050302.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 196, "start_aa": "Thr", "end_pos": 196, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr196", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 196 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZJT0-1", "uniprot_ac": "A0AAF6ZJT0", "uniprot_id": "A0AAF6ZJT0_BOVIN", "mass": { "chemical_mass": 21425.0, "monoisotopic_mass": 21425.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM243", "type": "recommended", "evidence": [ { "id": "A0AAF6ZJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0" } ] } ], "protein_names": [ { "name": "Transmembrane protein 243", "type": "synonym", "evidence": [ { "id": "A0AAF6ZJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZJT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM243", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0", "locus": { "chromosome": "4", "start_pos": 33248619, "end_pos": 33226960, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038283", "url": "https://www.ensembl.org/id/ENSBTAG00000038283" } ] } } ], "crossref": [ { "id": "A0AAF6ZJT0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZJT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR022564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28603:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28603:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZJT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GAPACGIGGLGRDAAWAGRVGLRQWPRVPAVGGDRGPAAQHTLAARAEGLSLPDSWHRIPAPAWIGTRALQCSQGSRACVRLETPRTYGTSGLDNRPLFGETSAKDRIINLVVGSLTSLLILVTLISAFVFPQLPPKPLNIFFAVCISLSSITACILIYWYRQGDLEPKFRNLIYYILFSIIMLCICANLYFHDVGK", "length": 197, "header": "tr|A0AAF6ZJT0-1|A0AAF6ZJT0_BOVIN Isoform 1 of Transmembrane protein 243 OS=Bos taurus OX=9913 GN=TMEM243 PE=4 SV=1 CANONICAL=A0AAF6ZJT0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZJT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJT0/entry", "sequence": { "sequence": "GAPACGIGGLGRDAAWAGRVGLRQWPRVPAVGGDRGPAAQHTLAARAEGLSLPDSWHRIPAPAWIGTRALQCSQGSRACVRLETPRTYGTSGLDNRPLFGETSAKDRIINLVVGSLTSLLILVTLISAFVFPQLPPKPLNIFFAVCISLSSITACILIYWYRQGDLEPKFRNLIYYILFSIIMLCICANLYFHDVGK", "length": 197, "header": "tr|A0AAF6ZJT0-1|A0AAF6ZJT0_BOVIN Isoform 1 of Transmembrane protein 243 OS=Bos taurus OX=9913 GN=TMEM243 PE=4 SV=1 CANONICAL=A0AAF6ZJT0-1" }, "locus": { "chromosome": "4", "start_pos": 33248152, "end_pos": 33226961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053511.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053511.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049794.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049794.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZK48-1", "uniprot_ac": "A0AAF6ZK48", "uniprot_id": "A0AAF6ZK48_BOVIN", "mass": { "chemical_mass": 17210.0, "monoisotopic_mass": 17210.0 }, "refseq": {}, "gene_names": [ { "name": "SDHAF1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZK48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48" } ] } ], "protein_names": [ { "name": "Succinate dehydrogenase complex assembly factor 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZK48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDHAF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48", "locus": { "chromosome": "18", "start_pos": 46670554, "end_pos": 46667770, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037461", "url": "https://www.ensembl.org/id/ENSBTAG00000037461" } ] } } ], "crossref": [ { "id": "A0AAF6ZK48", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZK48", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20268", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20268", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR008011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47046", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47046", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47046:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47046:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZK48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRREGAAKLGAGGGSSYGCVSPLLPPVHGRRSVPRGPAATMSRHSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHACLPRSDVLRIEYLYRRGRRQLQMLRSGHATAMGAFVRTRGPTEESNGAGAPGTLSGEGDDPRKPLDSMRTPKTPLDGR", "length": 158, "header": "tr|A0AAF6ZK48-1|A0AAF6ZK48_BOVIN Isoform 1 of Succinate dehydrogenase complex assembly factor 1 OS=Bos taurus OX=9913 GN=SDHAF1 PE=3 SV=1 CANONICAL=A0AAF6ZK48-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZK48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48/entry", "sequence": { "sequence": "MRREGAAKLGAGGGSSYGCVSPLLPPVHGRRSVPRGPAATMSRHSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHACLPRSDVLRIEYLYRRGRRQLQMLRSGHATAMGAFVRTRGPTEESNGAGAPGTLSGEGDDPRKPLDSMRTPKTPLDGR", "length": 158, "header": "tr|A0AAF6ZK48-1|A0AAF6ZK48_BOVIN Isoform 1 of Succinate dehydrogenase complex assembly factor 1 OS=Bos taurus OX=9913 GN=SDHAF1 PE=3 SV=1 CANONICAL=A0AAF6ZK48-1" }, "locus": { "chromosome": "18", "start_pos": 46668922, "end_pos": 46668449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055698.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055698.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050423.2", "url": "https://www.ensembl.org/id/ENSBTAP00000050423.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex II assembly", "id": "GO:0034553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034553", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZK48", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZK48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZK48" }, { "id": "PF05347", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Complex 1 LYR protein", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 103, "start_aa": "Arg", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZKY4-1", "uniprot_ac": "A0AAF6ZKY4", "uniprot_id": "A0AAF6ZKY4_BOVIN", "mass": { "chemical_mass": 17743.0, "monoisotopic_mass": 17743.0 }, "refseq": {}, "gene_names": [ { "name": "BSP1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ] } ], "protein_names": [ { "name": "Binder of sperm 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BSP1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZKY4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZKY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22918", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22918", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22918:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22918:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00040", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00040", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZKY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSPVTKGADGCWSVSGEQATMALQLGLFLIWAGVSVFLQLDPVNGDQDEGVSTEPTQDGPAELPEDEECVFPFVYRNRKHFDCTVHGSLFPWCSLDADYVGRWKYCAQRDYAKCVFPFIYGGKKYETCTKIGSMWMSWCSLSPNYDKDRAWKYC", "length": 156, "header": "tr|A0AAF6ZKY4-1|A0AAF6ZKY4_BOVIN Isoform 1 of Binder of sperm 1 OS=Bos taurus OX=9913 GN=BSP1 PE=3 SV=1 CANONICAL=A0AAF6ZKY4-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZKY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4/entry", "sequence": { "sequence": "MLRSPVTKGADGCWSVSGEQATMALQLGLFLIWAGVSVFLQLDPVNGDQDEGVSTEPTQDGPAELPEDEECVFPFVYRNRKHFDCTVHGSLFPWCSLDADYVGRWKYCAQRDYAKCVFPFIYGGKKYETCTKIGSMWMSWCSLSPNYDKDRAWKYC", "length": 156, "header": "tr|A0AAF6ZKY4-1|A0AAF6ZKY4_BOVIN Isoform 1 of Binder of sperm 1 OS=Bos taurus OX=9913 GN=BSP1 PE=3 SV=1 CANONICAL=A0AAF6ZKY4-1" }, "locus": { "chromosome": "18", "start_pos": 51622233, "end_pos": 51618369, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055955.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055955.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051819.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051819.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "phospholipid efflux", "id": "GO:0033700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033700", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ], "pmid": "" }, { "name": "positive regulation of sperm capacitation", "id": "GO:1902492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902492", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZKY4" }, { "id": "PS51092", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51092" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-II", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 110, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZL64-1", "uniprot_ac": "A0AAF6ZL64", "uniprot_id": "A0AAF6ZL64_BOVIN", "mass": { "chemical_mass": 70037.0, "monoisotopic_mass": 70037.0 }, "refseq": { "ac": "XP_005207622", "name": "transketolase-like protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207622" }, "gene_names": [ { "name": "TKTL2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZL64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64" } ] }, { "name": "TKTL2", "type": "synonym", "evidence": [ { "id": "XP_005207622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207622" } ] } ], "protein_names": [ { "name": "transketolase", "type": "recommended", "evidence": [ { "id": "A0AAF6ZL64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64/entry#names_and_taxonomy" } ] }, { "name": "2.2.1.1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZL64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64/entry#names_and_taxonomy" } ] }, { "name": "transketolase-like protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005207622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207622" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TKTL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64", "locus": { "chromosome": "6", "start_pos": 2171074, "end_pos": 2142353, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008947", "url": "https://www.ensembl.org/id/ENSBTAG00000008947" } ] } } ], "crossref": [ { "id": "A0AAF6ZL64", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZL64", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509186", "url": "https://www.ncbi.nlm.nih.gov/gene/509186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005207622", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207622", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZL64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZL64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSVDETAVAPPRLPRTGTWEGADMADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQTEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVAVFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTAIIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVSITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPERFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHCGVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSETAVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTIKPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNRKPSELLSIFGVSARHIIAAVKYTLMN", "length": 650, "header": "tr|A0AAF6ZL64-1|A0AAF6ZL64_BOVIN Isoform 1 of transketolase OS=Bos taurus OX=9913 GN=TKTL2 PE=3 SV=1 CANONICAL=A0AAF6ZL64-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZL64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64/entry", "sequence": { "sequence": "MPSVDETAVAPPRLPRTGTWEGADMADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQTEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVAVFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTAIIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVSITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPERFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHCGVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSETAVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTIKPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNRKPSELLSIFGVSARHIIAAVKYTLMN", "length": 650, "header": "tr|A0AAF6ZL64-1|A0AAF6ZL64_BOVIN Isoform 1 of transketolase OS=Bos taurus OX=9913 GN=TKTL2 PE=3 SV=1 CANONICAL=A0AAF6ZL64-1" }, "locus": { "chromosome": "6", "start_pos": 2171074, "end_pos": 2170964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011778.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011778.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052271.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052271.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64" } ], "pmid": "" }, { "name": "transketolase activity", "id": "GO:0004802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZL64", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZL64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZL64" }, { "id": "SM00861", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00861" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transketolase-like pyrimidine-binding", "eco_id": "ECO_0000259", "start_pos": 342, "end_pos": 506, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.2.1.1", "ec_name": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "2.2.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1" }, { "id": "2.2.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.2.1.1" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 371, "end_pos": 373 }, { "start_pos": 469, "end_pos": 471 }, { "start_pos": 500, "end_pos": 502 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZLH5-1", "uniprot_ac": "A0AAF6ZLH5", "uniprot_id": "A0AAF6ZLH5_BOVIN", "mass": { "chemical_mass": 19810.0, "monoisotopic_mass": 19810.0 }, "refseq": {}, "gene_names": [ { "name": "HBE4", "type": "recommended", "evidence": [ { "id": "A0AAF6ZLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ] } ], "protein_names": [ { "name": "Hemoglobin, beta, epsilon 4", "type": "synonym", "evidence": [ { "id": "A0AAF6ZLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HBE4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZLH5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZLH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08925", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08925", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZLH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNKRPHSEEAAQTCFWPIRITSKLPDTMVHFTTEEKAAVASLWAKVNVEVVGGESLARLLIVYPWTQRFFDSFGNLYSESAIMGNPKVKAHGRKVLNSFGNAIEHMDDLKGTFADLSELHCDKLHVDPENFRLLGNMILIVLATHFSKEFTPQMQASWQKLTNAVANALAHKYH", "length": 175, "header": "tr|A0AAF6ZLH5-1|A0AAF6ZLH5_BOVIN Isoform 1 of Hemoglobin, beta, epsilon 4 OS=Bos taurus OX=9913 GN=HBE4 PE=3 SV=1 CANONICAL=A0AAF6ZLH5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZLH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5/entry", "sequence": { "sequence": "MRNKRPHSEEAAQTCFWPIRITSKLPDTMVHFTTEEKAAVASLWAKVNVEVVGGESLARLLIVYPWTQRFFDSFGNLYSESAIMGNPKVKAHGRKVLNSFGNAIEHMDDLKGTFADLSELHCDKLHVDPENFRLLGNMILIVLATHFSKEFTPQMQASWQKLTNAVANALAHKYH", "length": 175, "header": "tr|A0AAF6ZLH5-1|A0AAF6ZLH5_BOVIN Isoform 1 of Hemoglobin, beta, epsilon 4 OS=Bos taurus OX=9913 GN=HBE4 PE=3 SV=1 CANONICAL=A0AAF6ZLH5-1" }, "locus": { "chromosome": "15", "start_pos": 48347787, "end_pos": 48346297, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053566.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053566.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052791.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052791.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ], "pmid": "" }, { "name": "oxygen carrier activity", "id": "GO:0005344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "hemoglobin complex", "id": "GO:0005833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZLH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZLH5" }, { "id": "PS01033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Globin", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 175, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZNJ0-1", "uniprot_ac": "A0AAF6ZNJ0", "uniprot_id": "A0AAF6ZNJ0_BOVIN", "mass": { "chemical_mass": 39364.0, "monoisotopic_mass": 39364.0 }, "refseq": {}, "gene_names": [ { "name": "UQCRFS1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZNJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ] } ], "protein_names": [ { "name": "Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZNJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UQCRFS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0", "locus": { "chromosome": "18", "start_pos": 997260, "end_pos": 1002304, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046786", "url": "https://www.ensembl.org/id/ENSBTAG00000046786" } ] } } ], "crossref": [ { "id": "A0AAF6ZNJ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZNJ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03470", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03470", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZNJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTGKTIALTIRTFVGNQALTNEITPHPALGPSPRPRRRGFPCWPRPLWRRGFLSAGALTSRSRALVARSRLRCGRKVVPVTGLGFGAAVAMLSVAARSGPFAPVLSATSRGVAGALRPLVQAAVPATSESPVLDLKRSVLCRESLRGQAAGRPLVASVSLNVPASVRYSHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPSYEFTSDDMVIVG", "length": 365, "header": "tr|A0AAF6ZNJ0-1|A0AAF6ZNJ0_BOVIN Isoform 1 of Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 OS=Bos taurus OX=9913 GN=UQCRFS1 PE=3 SV=1 CANONICAL=A0AAF6ZNJ0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZNJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0/entry", "sequence": { "sequence": "MTTGKTIALTIRTFVGNQALTNEITPHPALGPSPRPRRRGFPCWPRPLWRRGFLSAGALTSRSRALVARSRLRCGRKVVPVTGLGFGAAVAMLSVAARSGPFAPVLSATSRGVAGALRPLVQAAVPATSESPVLDLKRSVLCRESLRGQAAGRPLVASVSLNVPASVRYSHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPSYEFTSDDMVIVG", "length": 365, "header": "tr|A0AAF6ZNJ0-1|A0AAF6ZNJ0_BOVIN Isoform 1 of Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 OS=Bos taurus OX=9913 GN=UQCRFS1 PE=3 SV=1 CANONICAL=A0AAF6ZNJ0-1" }, "locus": { "chromosome": "18", "start_pos": 1002300, "end_pos": 997547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066053.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066053.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054196.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054196.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ], "pmid": "" }, { "name": "respiratory chain complex III", "id": "GO:0045275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045275", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ], "pmid": "" }, { "name": "quinol-cytochrome-c reductase activity", "id": "GO:0008121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008121", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZNJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNJ0" }, { "id": "PS51296", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51296" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rieske", "eco_id": "ECO_0000259", "start_pos": 278, "end_pos": 363, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZNP5-1", "uniprot_ac": "A0AAF6ZNP5", "uniprot_id": "A0AAF6ZNP5_BOVIN", "mass": { "chemical_mass": 39882.0, "monoisotopic_mass": 39882.0 }, "refseq": { "ac": "XP_005224800", "name": "THUMP domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224800" }, "gene_names": [ { "name": "THUMPD1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZNP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5" } ] }, { "name": "THUMPD1", "type": "synonym", "evidence": [ { "id": "XP_005224800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224800" } ] } ], "protein_names": [ { "name": "THUMP domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZNP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5/entry#names_and_taxonomy" } ] }, { "name": "THUMP domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005224800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224800" } ] } ], "function": [ { "annotation": "Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C).", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5#function" }, { "database": "UniProtKB", "id": "ARBA00053258", "url": "https://www.uniprot.org/uniprotkb/ARBA00053258#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THUMPD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5", "locus": { "chromosome": "25", "start_pos": 18452580, "end_pos": 18457021, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047673", "url": "https://www.ensembl.org/id/ENSBTAG00000047673" } ] } } ], "crossref": [ { "id": "A0AAF6ZNP5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZNP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11717", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11717", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524854", "url": "https://www.ncbi.nlm.nih.gov/gene/524854", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13452:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13452:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224800", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224800", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZNP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZNP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARIQQSPQPGGGKRKGKAQYVQAKRARRWDGGGPRQLEPGIQGILITCNMNERKCVEEAYSLLNEYGDDMYGPEKQFADKDQQPSGSEGEDDDVEAALKKEVGDIKASTEMRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDIYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELAGIVGSLNSENKVDLSNPQYTVVVEIIKAVCCLSVVKDYMLFRKYNLQEVVKSAKDLSQLNPKQAAQTGNGKEAKLESGDKSSQNDPAEGKNNQQVVPENSEELGPTESISETHVVNEGVAKPELASQVTEGSESNENDL", "length": 358, "header": "tr|A0AAF6ZNP5-1|A0AAF6ZNP5_BOVIN Isoform 1 of THUMP domain-containing protein 1 OS=Bos taurus OX=9913 GN=THUMPD1 PE=3 SV=1 CANONICAL=A0AAF6ZNP5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZNP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5/entry", "sequence": { "sequence": "MAARIQQSPQPGGGKRKGKAQYVQAKRARRWDGGGPRQLEPGIQGILITCNMNERKCVEEAYSLLNEYGDDMYGPEKQFADKDQQPSGSEGEDDDVEAALKKEVGDIKASTEMRLRRFQSVESGANNVVFIRTLGIEPEKLVHHILQDIYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSHMNREEVIKELAGIVGSLNSENKVDLSNPQYTVVVEIIKAVCCLSVVKDYMLFRKYNLQEVVKSAKDLSQLNPKQAAQTGNGKEAKLESGDKSSQNDPAEGKNNQQVVPENSEELGPTESISETHVVNEGVAKPELASQVTEGSESNENDL", "length": 358, "header": "tr|A0AAF6ZNP5-1|A0AAF6ZNP5_BOVIN Isoform 1 of THUMP domain-containing protein 1 OS=Bos taurus OX=9913 GN=THUMPD1 PE=3 SV=1 CANONICAL=A0AAF6ZNP5-1" }, "locus": { "chromosome": "25", "start_pos": 18456822, "end_pos": 18452697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064153.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064153.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054288.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054288.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZNP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNP5" }, { "id": "PS51165", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51165" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THUMP", "eco_id": "ECO_0000259", "start_pos": 148, "end_pos": 255, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 205, "end_pos": 207 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZNZ9-1", "uniprot_ac": "A0AAF6ZNZ9", "uniprot_id": "A0AAF6ZNZ9_BOVIN", "mass": { "chemical_mass": 24656.0, "monoisotopic_mass": 24656.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "DNA-directed RNA polymerases I and III subunit RPAC2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZNZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase I subunit D", "type": "synonym", "evidence": [ { "id": "A0AAF6ZNZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZNZ9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZNZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07029", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07029", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR008193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022905", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022905", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036603", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13946", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13946", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13946:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13946:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13656", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13656", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZNZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGIDCGLPQGGWSGEDVHNIMVSDESRIQNCMCYLAQVLELKGKPQVRTSSVGPSFLPACLPHPHASRHGAELPARPRHLRIPEAAPAMEEDQELERKMSGVKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIMKNPEVEFCGYTTTHPSESKINLRIQTRGALPAVEPFQRGLTDLMNVCQHVLDKFEASIKEYKDQKASRNEATF", "length": 221, "header": "tr|A0AAF6ZNZ9-1|A0AAF6ZNZ9_BOVIN Isoform 1 of DNA-directed RNA polymerases I and III subunit RPAC2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6ZNZ9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZNZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9/entry", "sequence": { "sequence": "MGIDCGLPQGGWSGEDVHNIMVSDESRIQNCMCYLAQVLELKGKPQVRTSSVGPSFLPACLPHPHASRHGAELPARPRHLRIPEAAPAMEEDQELERKMSGVKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIMKNPEVEFCGYTTTHPSESKINLRIQTRGALPAVEPFQRGLTDLMNVCQHVLDKFEASIKEYKDQKASRNEATF", "length": 221, "header": "tr|A0AAF6ZNZ9-1|A0AAF6ZNZ9_BOVIN Isoform 1 of DNA-directed RNA polymerases I and III subunit RPAC2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6ZNZ9-1" }, "locus": { "chromosome": "16", "start_pos": 29632070, "end_pos": 29631408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066201.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066201.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054585.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054585.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase activity", "id": "GO:0003899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003899", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase complex", "id": "GO:0000428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000428", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZNZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZNZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZNZ9" }, { "id": "PF13656", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13656" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA-directed RNA polymerase RBP11-like dimerisation", "eco_id": "ECO_0000259", "start_pos": 127, "end_pos": 200, "start_aa": "Cys", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZP66-1", "uniprot_ac": "A0AAF6ZP66", "uniprot_id": "A0AAF6ZP66_BOVIN", "mass": { "chemical_mass": 28689.0, "monoisotopic_mass": 28689.0 }, "refseq": {}, "gene_names": [ { "name": "MARCKSL1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66" } ] } ], "protein_names": [ { "name": "MARCKS-related protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66/entry#names_and_taxonomy" } ] }, { "name": "MARCKS-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAF6ZP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MARCKSL1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66", "locus": { "chromosome": "2", "start_pos": 121225407, "end_pos": 121222159, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046862", "url": "https://www.ensembl.org/id/ENSBTAG00000046862" } ] } } ], "crossref": [ { "id": "A0AAF6ZP66", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZP66", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14353:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14353:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZP66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGPAPSSGRIYIGDSAGGRRHSGAERSGAAVGAASGLGAERGCSLVSPRHPSPPNASPTPPPARPTRPNYPLRREPGAAPGAPPAEPPTMGSQSSKAPRGDVTAEEAAGASPAKVNGQENGHVKSNGDLSPKGEGESPPVNGTEEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEISACGEEGTAQEGKAAATPESQEPQAKGAEASAAAKGGDTEEAGPQAAEPSTPSGPESDPAPASEQNE", "length": 288, "header": "tr|A0AAF6ZP66-1|A0AAF6ZP66_BOVIN Isoform 1 of MARCKS-related protein OS=Bos taurus OX=9913 GN=MARCKSL1 PE=3 SV=1 CANONICAL=A0AAF6ZP66-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZP66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66/entry", "sequence": { "sequence": "MSGPAPSSGRIYIGDSAGGRRHSGAERSGAAVGAASGLGAERGCSLVSPRHPSPPNASPTPPPARPTRPNYPLRREPGAAPGAPPAEPPTMGSQSSKAPRGDVTAEEAAGASPAKVNGQENGHVKSNGDLSPKGEGESPPVNGTEEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEISACGEEGTAQEGKAAATPESQEPQAKGAEASAAAKGGDTEEAGPQAAEPSTPSGPESDPAPASEQNE", "length": 288, "header": "tr|A0AAF6ZP66-1|A0AAF6ZP66_BOVIN Isoform 1 of MARCKS-related protein OS=Bos taurus OX=9913 GN=MARCKSL1 PE=3 SV=1 CANONICAL=A0AAF6ZP66-1" }, "locus": { "chromosome": "2", "start_pos": 121224638, "end_pos": 121222967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066345.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066345.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054896.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054896.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 272, "start_aa": "Thr", "end_pos": 272, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr272", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 60, "start_aa": "Thr", "end_pos": 60, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr60", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZP66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 60, 272 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZPE1-1", "uniprot_ac": "A0AAF6ZPE1", "uniprot_id": "A0AAF6ZPE1_BOVIN", "mass": { "chemical_mass": 20890.0, "monoisotopic_mass": 20890.0 }, "refseq": {}, "gene_names": [ { "name": "DPPA3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZPE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1" } ] } ], "protein_names": [ { "name": "Developmental pluripotency associated 3", "type": "synonym", "evidence": [ { "id": "A0AAF6ZPE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZPE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPPA3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1", "locus": { "chromosome": "5", "start_pos": 101341323, "end_pos": 101333531, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046609", "url": "https://www.ensembl.org/id/ENSBTAG00000046609" } ] } } ], "crossref": [ { "id": "A0AAF6ZPE1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZPE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31577", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31577", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31577:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31577:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15549", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15549", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZPE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZPE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSSEDNPTWTLESLKTSIDDASQAMQVATQLSEMLATNLSNLTLNPSIKLPYLPEYPSQLTGQLPSEKTPHRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRVSSGLTLKDNYSSRRTLRFDQECEDSSVPVVIASLREILLMIIMRIITTQHTVIMPWNRMSHKPYSCTVLLLVILGSL", "length": 183, "header": "tr|A0AAF6ZPE1-1|A0AAF6ZPE1_BOVIN Isoform 1 of Developmental pluripotency associated 3 OS=Bos taurus OX=9913 GN=DPPA3 PE=4 SV=1 CANONICAL=A0AAF6ZPE1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZPE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPE1/entry", "sequence": { "sequence": "MDSSEDNPTWTLESLKTSIDDASQAMQVATQLSEMLATNLSNLTLNPSIKLPYLPEYPSQLTGQLPSEKTPHRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRVSSGLTLKDNYSSRRTLRFDQECEDSSVPVVIASLREILLMIIMRIITTQHTVIMPWNRMSHKPYSCTVLLLVILGSL", "length": 183, "header": "tr|A0AAF6ZPE1-1|A0AAF6ZPE1_BOVIN Isoform 1 of Developmental pluripotency associated 3 OS=Bos taurus OX=9913 GN=DPPA3 PE=4 SV=1 CANONICAL=A0AAF6ZPE1-1" }, "locus": { "chromosome": "5", "start_pos": 101340714, "end_pos": 101334485, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065996.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065996.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054822.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054822.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZQ93-1", "uniprot_ac": "A0AAF6ZQ93", "uniprot_id": "A0AAF6ZQ93_BOVIN", "mass": { "chemical_mass": 40451.0, "monoisotopic_mass": 40451.0 }, "refseq": { "ac": "XP_005206357", "name": "dnaJ homolog subfamily C member 22 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206357" }, "gene_names": [ { "name": "DNAJC22", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93" } ] }, { "name": "DNAJC22", "type": "synonym", "evidence": [ { "id": "XP_005206357", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206357" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 22", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93/entry#names_and_taxonomy" } ] }, { "name": "dnaJ homolog subfamily C member 22 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005206357", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206357" } ] } ], "function": [ { "annotation": "May function as a co-chaperone.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQ93", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93#function" }, { "database": "UniProtKB", "id": "ARBA00002080", "url": "https://www.uniprot.org/uniprotkb/ARBA00002080#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQ93", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC22", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93", "locus": { "chromosome": "5", "start_pos": 30467093, "end_pos": 30474006, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016398", "url": "https://www.ensembl.org/id/ENSBTAG00000016398" } ] } } ], "crossref": [ { "id": "A0AAF6ZQ93", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZQ93", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515215", "url": "https://www.ncbi.nlm.nih.gov/gene/515215", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44733", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44733", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44733:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44733:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005206357", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206357", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQ93", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQ93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKGLLMTYTLWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWMLPSFVAQANRAQEQRQGSGRGTPPLSLIRFVAQMIVGMYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDLKNTLGAAFLTSPIFYGRPIAILPISLAASITAQKHRRYKPSVGSETLSVRLYRLGLAYLAFTGPLVHSVLCHTAVTLSYVADTLGSFLSWFSFFPLLGRLLESVLLLPFRAWKLLVGDHGISSSYFQEWEKLYEFVHSFQDEKRQLALQVFGLSEGATNEEIHGRYRELVKTWHPDHNRYQMEEAQRRFLEIQAAYEVLRQPRKPRGSWRSNATINTFKRVLGLPWWSSG", "length": 361, "header": "tr|A0AAF6ZQ93-1|A0AAF6ZQ93_BOVIN Isoform 1 of DnaJ homolog subfamily C member 22 OS=Bos taurus OX=9913 GN=DNAJC22 PE=4 SV=1 CANONICAL=A0AAF6ZQ93-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZQ93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93/entry", "sequence": { "sequence": "MAKGLLMTYTLWAVGGPAGLHHLYLGRDSHALLWMLTLGGGGLGWLWEFWMLPSFVAQANRAQEQRQGSGRGTPPLSLIRFVAQMIVGMYFGLVALISLSFMASFYIVGLPLAVGLGVLLVAAVGNQTSDLKNTLGAAFLTSPIFYGRPIAILPISLAASITAQKHRRYKPSVGSETLSVRLYRLGLAYLAFTGPLVHSVLCHTAVTLSYVADTLGSFLSWFSFFPLLGRLLESVLLLPFRAWKLLVGDHGISSSYFQEWEKLYEFVHSFQDEKRQLALQVFGLSEGATNEEIHGRYRELVKTWHPDHNRYQMEEAQRRFLEIQAAYEVLRQPRKPRGSWRSNATINTFKRVLGLPWWSSG", "length": 361, "header": "tr|A0AAF6ZQ93-1|A0AAF6ZQ93_BOVIN Isoform 1 of DnaJ homolog subfamily C member 22 OS=Bos taurus OX=9913 GN=DNAJC22 PE=4 SV=1 CANONICAL=A0AAF6ZQ93-1" }, "locus": { "chromosome": "5", "start_pos": 30473167, "end_pos": 30468097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063126.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063126.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055590.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055590.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQ93", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZQ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ93" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 277, "end_pos": 344, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 343, "end_pos": 345 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZQF2-1", "uniprot_ac": "A0AAF6ZQF2", "uniprot_id": "A0AAF6ZQF2_BOVIN", "mass": { "chemical_mass": 51693.0, "monoisotopic_mass": 51693.0 }, "refseq": {}, "gene_names": [ { "name": "TUBG1", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ] } ], "protein_names": [ { "name": "Tubulin gamma chain", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2#function" }, { "database": "UniProtKB", "id": "ARBA00093405", "url": "https://www.uniprot.org/uniprotkb/ARBA00093405#function" }, { "database": "UniProtKB", "id": "RU000352", "url": "https://www.uniprot.org/uniprotkb/RU000352#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUBG1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2", "locus": { "chromosome": "19", "start_pos": 42683624, "end_pos": 42676139, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048152", "url": "https://www.ensembl.org/id/ENSBTAG00000048152" } ] } } ], "crossref": [ { "id": "A0AAF6ZQF2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZQF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02188", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02188", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDIFKENFDELDTSREIVQQLIDEYHAATRPDYISWGTQEQVCRW", "length": 455, "header": "tr|A0AAF6ZQF2-1|A0AAF6ZQF2_BOVIN Isoform 1 of Tubulin gamma chain OS=Bos taurus OX=9913 GN=TUBG1 PE=3 SV=1 CANONICAL=A0AAF6ZQF2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZQF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2/entry", "sequence": { "sequence": "MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDIFKENFDELDTSREIVQQLIDEYHAATRPDYISWGTQEQVCRW", "length": 455, "header": "tr|A0AAF6ZQF2-1|A0AAF6ZQF2_BOVIN Isoform 1 of Tubulin gamma chain OS=Bos taurus OX=9913 GN=TUBG1 PE=3 SV=1 CANONICAL=A0AAF6ZQF2-1" }, "locus": { "chromosome": "19", "start_pos": 42682620, "end_pos": 42676235, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064686.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064686.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055684.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055684.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "mitotic spindle microtubule", "id": "GO:1990498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990498", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "polar microtubule", "id": "GO:0005827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005827", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "pericentriolar material", "id": "GO:0000242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000242", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "gamma-tubulin complex", "id": "GO:0000930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000930", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "microtubule nucleation", "id": "GO:0007020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" }, { "name": "meiotic spindle organization", "id": "GO:0000212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000212", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZQF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" }, { "id": "SM00865", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubulin/FtsZ 2-layer sandwich", "eco_id": "ECO_0000259", "start_pos": 249, "end_pos": 393, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZQF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQF2" }, { "id": "SM00864", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00864" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubulin/FtsZ GTPase", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 247, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 380, "end_pos": 382 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZQK7-1", "uniprot_ac": "A0AAF6ZQK7", "uniprot_id": "A0AAF6ZQK7_BOVIN", "mass": { "chemical_mass": 13750.0, "monoisotopic_mass": 13750.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "40S ribosomal protein S25", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7#function" }, { "database": "UniProtKB", "id": "ARBA00045746", "url": "https://www.uniprot.org/uniprotkb/ARBA00045746#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZQK7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZQK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZQK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPKDDKKKDARKSAKKDKDPVNKSGGKAKKKKWFKGKVRDKLNKLVLFDKATYDKLCKEVPNYTLITSAVVSERPKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDS", "length": 124, "header": "tr|A0AAF6ZQK7-1|A0AAF6ZQK7_BOVIN Isoform 1 of 40S ribosomal protein S25 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6ZQK7-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZQK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7/entry", "sequence": { "sequence": "MPPKDDKKKDARKSAKKDKDPVNKSGGKAKKKKWFKGKVRDKLNKLVLFDKATYDKLCKEVPNYTLITSAVVSERPKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDS", "length": 124, "header": "tr|A0AAF6ZQK7-1|A0AAF6ZQK7_BOVIN Isoform 1 of 40S ribosomal protein S25 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAF6ZQK7-1" }, "locus": { "chromosome": "9", "start_pos": 44161477, "end_pos": 44161103, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025270.3", "url": "https://www.ensembl.org/id/ENSBTAT00000025270.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055632.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055632.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQK7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 23, "end_pos": 25 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZQP5-1", "uniprot_ac": "A0AAF6ZQP5", "uniprot_id": "A0AAF6ZQP5_BOVIN", "mass": { "chemical_mass": 39022.0, "monoisotopic_mass": 39022.0 }, "refseq": { "ac": "XP_005227719", "name": "vasopressin V2 receptor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227719" }, "gene_names": [ { "name": "AVPR2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ] }, { "name": "AVPR2", "type": "synonym", "evidence": [ { "id": "XP_005227719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227719" } ] } ], "protein_names": [ { "name": "Vasopressin V2 receptor", "type": "recommended", "evidence": [ { "id": "A0AAF6ZQP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5/entry#names_and_taxonomy" } ] }, { "name": "vasopressin V2 receptor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005227719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227719" } ] } ], "function": [ { "annotation": "G-protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5#function" }, { "database": "UniProtKB", "id": "RU046427", "url": "https://www.uniprot.org/uniprotkb/RU046427#function" }, { "database": "UniProtKB", "id": "ARBA00094505", "url": "https://www.uniprot.org/uniprotkb/ARBA00094505#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AVPR2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5", "locus": { "chromosome": "X", "start_pos": 37125019, "end_pos": 37122381, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047138", "url": "https://www.ensembl.org/id/ENSBTAG00000047138" } ] } } ], "crossref": [ { "id": "A0AAF6ZQP5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZQP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15388", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15388", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281642", "url": "https://www.ncbi.nlm.nih.gov/gene/281642", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24241:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24241:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFMASTTSAGNGSEGELLTARDPLLAQAELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAHRHGGGTHWNRPVLLAWAFSLLFSLPQLFIFAQRDVDGSGVLDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLGPGPVPRAGGPRRGCRPGSPAEGARVSAAVAKTVKMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCTWRRAPPSPGPQEESCATASSFLAKDTPS", "length": 359, "header": "tr|A0AAF6ZQP5-1|A0AAF6ZQP5_BOVIN Isoform 1 of Vasopressin V2 receptor OS=Bos taurus OX=9913 GN=AVPR2 PE=3 SV=1 CANONICAL=A0AAF6ZQP5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZQP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5/entry", "sequence": { "sequence": "MFMASTTSAGNGSEGELLTARDPLLAQAELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAHRHGGGTHWNRPVLLAWAFSLLFSLPQLFIFAQRDVDGSGVLDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLGPGPVPRAGGPRRGCRPGSPAEGARVSAAVAKTVKMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCTWRRAPPSPGPQEESCATASSFLAKDTPS", "length": 359, "header": "tr|A0AAF6ZQP5-1|A0AAF6ZQP5_BOVIN Isoform 1 of Vasopressin V2 receptor OS=Bos taurus OX=9913 GN=AVPR2 PE=3 SV=1 CANONICAL=A0AAF6ZQP5-1" }, "locus": { "chromosome": "X", "start_pos": 37124758, "end_pos": 37123207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065044.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065044.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055744.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055744.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" }, { "name": "renal water absorption", "id": "GO:0070295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070295", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" }, { "name": "positive regulation of intracellular signal transduction", "id": "GO:1902533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902533", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "vasopressin receptor activity", "id": "GO:0005000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005000", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZQP5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZQP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQP5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 313, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZRN5-1", "uniprot_ac": "A0AAF6ZRN5", "uniprot_id": "A0AAF6ZRN5_BOVIN", "mass": { "chemical_mass": 11018.0, "monoisotopic_mass": 11018.0 }, "refseq": {}, "gene_names": [ { "name": "S100A12", "type": "recommended", "evidence": [ { "id": "A0AAF6ZRN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ] } ], "protein_names": [ { "name": "Protein S100", "type": "recommended", "evidence": [ { "id": "A0AAF6ZRN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAF6ZRN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100A12", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5", "locus": { "chromosome": "3", "start_pos": 17104169, "end_pos": 17102730, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012638", "url": "https://www.ensembl.org/id/ENSBTAG00000012638" } ] } } ], "crossref": [ { "id": "A0AAF6ZRN5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZRN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZRN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FGKMTKLEDHLEGIINIFHQYSVRVGHFDTLNKRELKQLITKELPKTLQNTKDQPTIDKIFQDLDADKDGAVSFEEFVVLVSRVLKTAHIDIHKE", "length": 95, "header": "tr|A0AAF6ZRN5-1|A0AAF6ZRN5_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100A12 PE=3 SV=1 CANONICAL=A0AAF6ZRN5-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZRN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5/entry", "sequence": { "sequence": "FGKMTKLEDHLEGIINIFHQYSVRVGHFDTLNKRELKQLITKELPKTLQNTKDQPTIDKIFQDLDADKDGAVSFEEFVVLVSRVLKTAHIDIHKE", "length": 95, "header": "tr|A0AAF6ZRN5-1|A0AAF6ZRN5_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100A12 PE=3 SV=1 CANONICAL=A0AAF6ZRN5-1" }, "locus": { "chromosome": "3", "start_pos": 17104060, "end_pos": 17103318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063314.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063314.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056088.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056088.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RAGE receptor binding", "id": "GO:0050786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050786", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "id": "GO:0061844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "killing of cells of another organism", "id": "GO:0031640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZRN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRN5" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 87, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZRR0-1", "uniprot_ac": "A0AAF6ZRR0", "uniprot_id": "A0AAF6ZRR0_BOVIN", "mass": { "chemical_mass": 46115.0, "monoisotopic_mass": 46115.0 }, "refseq": {}, "gene_names": [ { "name": "BMP15", "type": "recommended", "evidence": [ { "id": "A0AAF6ZRR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0" } ] } ], "protein_names": [ { "name": "Bone morphotic protein 15", "type": "synonym", "evidence": [ { "id": "A0AAF6ZRR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRR0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BMP15", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0", "locus": { "chromosome": "X", "start_pos": 88811597, "end_pos": 88803745, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045782", "url": "https://www.ensembl.org/id/ENSBTAG00000045782" } ] } } ], "crossref": [ { "id": "A0AAF6ZRR0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZRR0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19402", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19402", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZRR0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZRR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLNTKLFKMVLLSILRILLLWGLVLFMEHRVQMTQVGQPSIAHLPEAPTLPLIQELLEEAPGKQQRKPRILGHPLRYMLELYQRSADASGHPRENRTIGATMVRLVRPLASVARPLRGSWHIQTLDFPLRPNRVAYQLVRATVVYRHQLHLTHSHLSCHVEPWVQKSPTNHFPSSGRGSSKPSLLPKAWTEMDIMEHVGQKLWNHKGRRVLRLRFVCQQPRGSEVREFWWHGTSSLDTVFLLLYFNDTQSVQKTKPLPKGLKEFTEKDPSLLLRRARQAGSIASEVPGPSREHDGPESNLCSLHPFQVSFQQLGWDHWIIAPHLYTPNYCKGVCPRVLHYGLNSPNHAIIQNLVNELVDQSVPQPSCVPYKYVPISILLIEANGSILYKEYEGMIAQSCTCR", "length": 403, "header": "tr|A0AAF6ZRR0-1|A0AAF6ZRR0_BOVIN Isoform 1 of Bone morphotic protein 15 OS=Bos taurus OX=9913 GN=BMP15 PE=3 SV=1 CANONICAL=A0AAF6ZRR0-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZRR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0/entry", "sequence": { "sequence": "MLLNTKLFKMVLLSILRILLLWGLVLFMEHRVQMTQVGQPSIAHLPEAPTLPLIQELLEEAPGKQQRKPRILGHPLRYMLELYQRSADASGHPRENRTIGATMVRLVRPLASVARPLRGSWHIQTLDFPLRPNRVAYQLVRATVVYRHQLHLTHSHLSCHVEPWVQKSPTNHFPSSGRGSSKPSLLPKAWTEMDIMEHVGQKLWNHKGRRVLRLRFVCQQPRGSEVREFWWHGTSSLDTVFLLLYFNDTQSVQKTKPLPKGLKEFTEKDPSLLLRRARQAGSIASEVPGPSREHDGPESNLCSLHPFQVSFQQLGWDHWIIAPHLYTPNYCKGVCPRVLHYGLNSPNHAIIQNLVNELVDQSVPQPSCVPYKYVPISILLIEANGSILYKEYEGMIAQSCTCR", "length": 403, "header": "tr|A0AAF6ZRR0-1|A0AAF6ZRR0_BOVIN Isoform 1 of Bone morphotic protein 15 OS=Bos taurus OX=9913 GN=BMP15 PE=3 SV=1 CANONICAL=A0AAF6ZRR0-1" }, "locus": { "chromosome": "X", "start_pos": 88810593, "end_pos": 88803944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064918.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064918.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056137.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056137.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRR0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRR0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZRR0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZRR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZRR0" }, { "id": "PS51362", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51362" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TGF-beta family profile", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 403, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 247, "end_pos": 249 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZWF9-1", "uniprot_ac": "A0AAF6ZWF9", "uniprot_id": "A0AAF6ZWF9_BOVIN", "mass": { "chemical_mass": 32425.0, "monoisotopic_mass": 32425.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112441481", "type": "recommended", "evidence": [ { "id": "A0AAF6ZWF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9" } ] } ], "protein_names": [ { "name": "Glycine N-acyltransferase-like protein", "type": "recommended", "evidence": [ { "id": "A0AAF6ZWF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.-", "type": "synonym", "evidence": [ { "id": "A0AAF6ZWF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWF9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112441481", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9", "locus": {} } ], "crossref": [ { "id": "A0AAF6ZWF9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZWF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15298:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15298:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08444", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZWF9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZWF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFHLQGPQLLQMLEKSLRKSLPESLKVYGVVFHMNQGNPFNLKALVDKWPDFKTVVIRPQEQEMADDFDHYTNTYQIYSKDLNNCQESLATSDVINWKQHLQIQSSQSSLNEVIQNLACILYVMPETARKLLPSLPETKNLPVGYGAPKAINQEMFKLSSMDPTHAALVNKFWHFGGNKRSQRFIERCIRAFPTFCLLGPEGTPASWSLMDQTGEIRMGATLPEYRGHGLISHMLAVHTRALDQLGIPVYNHTDKANKIVQKVSHNLHHIAIPHGWNQWNCEPL", "length": 284, "header": "tr|A0AAF6ZWF9-1|A0AAF6ZWF9_BOVIN Isoform 1 of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=LOC112441481 PE=3 SV=1 CANONICAL=A0AAF6ZWF9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZWF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9/entry", "sequence": { "sequence": "MFHLQGPQLLQMLEKSLRKSLPESLKVYGVVFHMNQGNPFNLKALVDKWPDFKTVVIRPQEQEMADDFDHYTNTYQIYSKDLNNCQESLATSDVINWKQHLQIQSSQSSLNEVIQNLACILYVMPETARKLLPSLPETKNLPVGYGAPKAINQEMFKLSSMDPTHAALVNKFWHFGGNKRSQRFIERCIRAFPTFCLLGPEGTPASWSLMDQTGEIRMGATLPEYRGHGLISHMLAVHTRALDQLGIPVYNHTDKANKIVQKVSHNLHHIAIPHGWNQWNCEPL", "length": 284, "header": "tr|A0AAF6ZWF9-1|A0AAF6ZWF9_BOVIN Isoform 1 of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=LOC112441481 PE=3 SV=1 CANONICAL=A0AAF6ZWF9-1" }, "locus": { "chromosome": "15", "start_pos": 82160656, "end_pos": 82145544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082080.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082080.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058372.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058372.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 203, "start_aa": "Thr", "end_pos": 203, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr203", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWF9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glycine N-acyltransferase activity", "id": "GO:0047961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047961", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZWF9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZWF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9" }, { "id": "PF08444", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08444" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycine N-acyltransferase C-terminal", "eco_id": "ECO_0000259", "start_pos": 195, "end_pos": 283, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF6ZWF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWF9" }, { "id": "PF06021", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycine N-acyltransferase N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 193, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 203 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZX18-1", "uniprot_ac": "A0AAF6ZX18", "uniprot_id": "A0AAF6ZX18_BOVIN", "mass": { "chemical_mass": 47326.0, "monoisotopic_mass": 47326.0 }, "refseq": {}, "gene_names": [ { "name": "UBE2E3", "type": "recommended", "evidence": [ { "id": "A0AAF6ZX18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18" } ] } ], "protein_names": [ { "name": "E2 ubiquitin-conjugating enzyme", "type": "recommended", "evidence": [ { "id": "A0AAF6ZX18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.23", "type": "synonym", "evidence": [ { "id": "A0AAF6ZX18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZX18", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE2E3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18", "locus": { "chromosome": "2", "start_pos": 15639653, "end_pos": 15732604, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043956", "url": "https://www.ensembl.org/id/ENSBTAG00000043956" } ] } } ], "crossref": [ { "id": "A0AAF6ZX18", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZX18", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23793", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23793", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24068", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24068", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6ZX18", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZX18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DLSLWKAEGQRETEADHLVSKSFFLPSVSKTSSCPVSSQEGQVAAFLCFRTWPSQRHPLVSNLPEQWGTTGHATQALAQAWGLRGLRWPVRWKRGVGQPGHDPSSSLWGRVVQWAASLRRRAQAGSHPAAQRPRETAPAPPPSPARAPRPRAAGASPPGPRRALCPGRARADACAPRVKGGAERPRGSAREQLAPAGRRRRAPLRQRRASGPGGRPSFPRNNFTKMSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT", "length": 432, "header": "tr|A0AAF6ZX18-1|A0AAF6ZX18_BOVIN Isoform 1 of E2 ubiquitin-conjugating enzyme OS=Bos taurus OX=9913 GN=UBE2E3 PE=3 SV=1 CANONICAL=A0AAF6ZX18-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZX18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18/entry", "sequence": { "sequence": "DLSLWKAEGQRETEADHLVSKSFFLPSVSKTSSCPVSSQEGQVAAFLCFRTWPSQRHPLVSNLPEQWGTTGHATQALAQAWGLRGLRWPVRWKRGVGQPGHDPSSSLWGRVVQWAASLRRRAQAGSHPAAQRPRETAPAPPPSPARAPRPRAAGASPPGPRRALCPGRARADACAPRVKGGAERPRGSAREQLAPAGRRRRAPLRQRRASGPGGRPSFPRNNFTKMSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT", "length": 432, "header": "tr|A0AAF6ZX18-1|A0AAF6ZX18_BOVIN Isoform 1 of E2 ubiquitin-conjugating enzyme OS=Bos taurus OX=9913 GN=UBE2E3 PE=3 SV=1 CANONICAL=A0AAF6ZX18-1" }, "locus": { "chromosome": "2", "start_pos": 15732405, "end_pos": 15640343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070217.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070217.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058709.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058709.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZX18", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZX18", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZX18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZX18" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 286, "end_pos": 432, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.23", "ec_name": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "2.3.2.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.23" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 377, "end_pos": 379 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6ZZH8-1", "uniprot_ac": "A0AAF6ZZH8", "uniprot_id": "A0AAF6ZZH8_BOVIN", "mass": { "chemical_mass": 84799.0, "monoisotopic_mass": 84799.0 }, "refseq": { "ac": "XP_005201994", "name": "angiomotin-like protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201994" }, "gene_names": [ { "name": "AMOTL2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" } ] }, { "name": "AMOTL2", "type": "synonym", "evidence": [ { "id": "XP_005201994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201994" } ] } ], "protein_names": [ { "name": "Angiomotin-like protein 2", "type": "recommended", "evidence": [ { "id": "A0AAF6ZZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8/entry#names_and_taxonomy" } ] }, { "name": "angiomotin-like protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201994" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AMOTL2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8", "locus": { "chromosome": "1", "start_pos": 134965219, "end_pos": 134947876, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000742", "url": "https://www.ensembl.org/id/ENSBTAG00000000742" } ] } } ], "crossref": [ { "id": "A0AAF6ZZH8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6ZZH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "538514", "url": "https://www.ncbi.nlm.nih.gov/gene/538514", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024646", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024646", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14826", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14826", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14826:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14826:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005201994", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZZH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQAPMEIMAPEDSQVLQQATRQEPQGQEHQGTETHLAENGLYRLCPQPGKGEELPTYEEAKAHSQYYASQQAGPWPHVGDRDPRGPPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARTPSHMSASHSFPQLARNQQGPPARGAPTAEGPEPRGPPPQYPHVMLAHETTSAVTDPRYRARGSPHFQHAEVRILQAQVPPVFLPQQQQQYQYLQQPQERHPPPHLAALSPPGVEGPASTQASLATSGSTHLAQMETVLRENARLQRDNERLQRELESTAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALSNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGTPGGGGGSGGTPELSALRLSEQLREKEEQVLALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKVTPGSLRPAKSVPSIFVAAAAGTQGWQGHSSSERQVDASAQLAAADRAPLEEPVAVAPLAAHAKHGSRDGSTQTDGPPDSLEPDSLLGCSSGQRTASLDSIATSRVQDFSDMVEILI", "length": 767, "header": "tr|A0AAF6ZZH8-1|A0AAF6ZZH8_BOVIN Isoform 1 of Angiomotin-like protein 2 OS=Bos taurus OX=9913 GN=AMOTL2 PE=3 SV=1 CANONICAL=A0AAF6ZZH8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZZH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8/entry", "sequence": { "sequence": "MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQAPMEIMAPEDSQVLQQATRQEPQGQEHQGTETHLAENGLYRLCPQPGKGEELPTYEEAKAHSQYYASQQAGPWPHVGDRDPRGPPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARTPSHMSASHSFPQLARNQQGPPARGAPTAEGPEPRGPPPQYPHVMLAHETTSAVTDPRYRARGSPHFQHAEVRILQAQVPPVFLPQQQQQYQYLQQPQERHPPPHLAALSPPGVEGPASTQASLATSGSTHLAQMETVLRENARLQRDNERLQRELESTAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALSNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGTPGGGGGSGGTPELSALRLSEQLREKEEQVLALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKVTPGSLRPAKSVPSIFVAAAAGTQGWQGHSSSERQVDASAQLAAADRAPLEEPVAVAPLAAHAKHGSRDGSTQTDGPPDSLEPDSLLGCSSGQRTASLDSIATSRVQDFSDMVEILI", "length": 767, "header": "tr|A0AAF6ZZH8-1|A0AAF6ZZH8_BOVIN Isoform 1 of Angiomotin-like protein 2 OS=Bos taurus OX=9913 GN=AMOTL2 PE=3 SV=1 CANONICAL=A0AAF6ZZH8-1" }, "locus": { "chromosome": "1", "start_pos": 134964215, "end_pos": 134950998, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077451.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077451.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060697.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060697.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 534, "start_aa": "Thr", "end_pos": 534, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr534", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" } ], "pmid": "" }, { "name": "podosome", "id": "GO:0002102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" } ], "pmid": "" }, { "name": "positive regulation of protein localization", "id": "GO:1903829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903829", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF6ZZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZH8" }, { "id": "PF12240", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Angiomotin C-terminal", "eco_id": "ECO_0000259", "start_pos": 476, "end_pos": 679, "start_aa": "Tyr", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 534 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7A422-1", "uniprot_ac": "A0AAF7A422", "uniprot_id": "A0AAF7A422_BOVIN", "mass": { "chemical_mass": 19378.0, "monoisotopic_mass": 19378.0 }, "refseq": {}, "gene_names": [ { "name": "CATHL6", "type": "recommended", "evidence": [ { "id": "A0AAF7A422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422" } ] } ], "protein_names": [ { "name": "Cathelicidin 6", "type": "synonym", "evidence": [ { "id": "A0AAF7A422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A422", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CATHL6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422", "locus": {} } ], "crossref": [ { "id": "A0AAF7A422", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7A422", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10206:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10206:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00666", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00666", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF7A422", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A422-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METQRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQFNERSSEANLYRLLELDPPPKEDDENPNIPKPVSFRVKETVCPRTSQQPAEQCDFKENGLVKQCVGTVTLDAVKGKINVTCEELQSVGRFKRFRKKFKKLFKKLSPVIPLLHLGSLHDPNPTMNMRM", "length": 171, "header": "tr|A0AAF7A422-1|A0AAF7A422_BOVIN Isoform 1 of Cathelicidin 6 OS=Bos taurus OX=9913 GN=CATHL6 PE=3 SV=1 CANONICAL=A0AAF7A422-1" }, "isoforms": [ { "isoform_ac": "A0AAF7A422-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422/entry", "sequence": { "sequence": "METQRASLSLGRWSLWLLLLGLALPSASAQALSYREAVLRAVDQFNERSSEANLYRLLELDPPPKEDDENPNIPKPVSFRVKETVCPRTSQQPAEQCDFKENGLVKQCVGTVTLDAVKGKINVTCEELQSVGRFKRFRKKFKKLFKKLSPVIPLLHLGSLHDPNPTMNMRM", "length": 171, "header": "tr|A0AAF7A422-1|A0AAF7A422_BOVIN Isoform 1 of Cathelicidin 6 OS=Bos taurus OX=9913 GN=CATHL6 PE=3 SV=1 CANONICAL=A0AAF7A422-1" }, "locus": { "chromosome": "22", "start_pos": 51665265, "end_pos": 51663088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079324.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079324.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062320.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062320.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A422", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A422", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A422" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7ABT5-1", "uniprot_ac": "A0AAF7ABT5", "uniprot_id": "A0AAF7ABT5_BOVIN", "mass": { "chemical_mass": 31153.0, "monoisotopic_mass": 31153.0 }, "refseq": {}, "gene_names": [ { "name": "PAFAH1B3", "type": "recommended", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] } ], "protein_names": [ { "name": "Platelet-activating factor acetylhydrolase IB subunit alpha1", "type": "recommended", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.47", "type": "synonym", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5/entry#names_and_taxonomy" } ] }, { "name": "PAF acetylhydrolase 29 kDa subunit", "type": "synonym", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5/entry#names_and_taxonomy" } ] }, { "name": "PAF-AH subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5#function" }, { "database": "UniProtKB", "id": "ARBA00046067", "url": "https://www.uniprot.org/uniprotkb/ARBA00046067#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAFAH1B3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5", "locus": { "chromosome": "18", "start_pos": 50982284, "end_pos": 50978685, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019787", "url": "https://www.ensembl.org/id/ENSBTAG00000019787" } ] } } ], "crossref": [ { "id": "A0AAF7ABT5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7ABT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01820", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01820", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR013830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11852", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11852", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11852:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11852:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13472", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13472", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17777", "url": "https://www.rhea-db.org/rhea/17777", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40479", "url": "https://www.rhea-db.org/rhea/40479", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "41704", "url": "https://www.rhea-db.org/rhea/41704", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ABT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRDGLACPRAPRCLGAPAAAVARETGRSRKRRTSPLRGRRGGSEGAEASGKMSGDENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAIVQLVNERQPQARVVVLGLLPRGQHPNPLREKNRRVNELVRAALAGHPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLTQDQGQGGAPLPEPSP", "length": 283, "header": "tr|A0AAF7ABT5-1|A0AAF7ABT5_BOVIN Isoform 1 of Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Bos taurus OX=9913 GN=PAFAH1B3 PE=3 SV=2 CANONICAL=A0AAF7ABT5-1" }, "isoforms": [ { "isoform_ac": "A0AAF7ABT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5/entry", "sequence": { "sequence": "MRDGLACPRAPRCLGAPAAAVARETGRSRKRRTSPLRGRRGGSEGAEASGKMSGDENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAIVQLVNERQPQARVVVLGLLPRGQHPNPLREKNRRVNELVRAALAGHPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLTQDQGQGGAPLPEPSP", "length": 283, "header": "tr|A0AAF7ABT5-1|A0AAF7ABT5_BOVIN Isoform 1 of Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Bos taurus OX=9913 GN=PAFAH1B3 PE=3 SV=2 CANONICAL=A0AAF7ABT5-1" }, "locus": { "chromosome": "18", "start_pos": 50981513, "end_pos": 50978839, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067093.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067093.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066532.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066532.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ], "pmid": "" }, { "name": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "id": "GO:0003847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003847", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ABT5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17777", "name": "", "equation": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P79106-1", "A0AAF7ABT5-1", "P68401-1", "Q28017-1", "Q29460-1", "Q3SZ16-1", "F1MGH2-1" ], "evidence": [ { "id": "17777", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17777" } ] }, { "id": "40479", "name": "", "equation": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P79106-1", "A0AAF7ABT5-1", "P68401-1", "Q0VC00-1", "Q28017-1", "Q29460-1", "Q3SZ16-1", "E1BB89-1" ], "evidence": [ { "id": "40479", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40479" } ] }, { "id": "41704", "name": "", "equation": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF7ABT5-1", "P68401-1", "Q29460-1", "Q3SZ16-1" ], "evidence": [ { "id": "41704", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41704" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF7ABT5", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] } ] }, { "uniprot_ac": "E1BB89", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] } ] }, { "uniprot_ac": "F1MGH2", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P79106", "gene_name": "PAFAH2", "activity": [ { "ec_number": "2.3.1.149", "activity": "a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine.", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] } ] }, { "uniprot_ac": "Q0VC00", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] } ] }, { "uniprot_ac": "Q28017", "gene_name": "PLA2G7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q28017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28017" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q28017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28017" } ] } ] }, { "uniprot_ac": "Q29460", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q29460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29460" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q29460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29460" } ] } ] }, { "uniprot_ac": "Q3SZ16", "gene_name": "IAH1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" }, { "id": "PF13472", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13472" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SGNH hydrolase-type esterase", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 252, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.47", "ec_name": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "3.1.1.47", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47" }, { "id": "3.1.1.47", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.47" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7ACE3-1", "uniprot_ac": "A0AAF7ACE3", "uniprot_id": "A0AAF7ACE3_BOVIN", "mass": { "chemical_mass": 35459.0, "monoisotopic_mass": 35459.0 }, "refseq": {}, "gene_names": [ { "name": "PIH1D1", "type": "recommended", "evidence": [ { "id": "A0AAF7ACE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ] } ], "protein_names": [ { "name": "PIH1 domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF7ACE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3#function" }, { "database": "UniProtKB", "id": "ARBA00046233", "url": "https://www.uniprot.org/uniprotkb/ARBA00046233#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIH1D1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3", "locus": { "chromosome": "18", "start_pos": 55903419, "end_pos": 55910639, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016526", "url": "https://www.ensembl.org/id/ENSBTAG00000016526" } ] } } ], "crossref": [ { "id": "A0AAF7ACE3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7ACE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR012981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22997:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22997:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ACE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSASQPSLSQTFFHGLRGSLPEGTWRAMADSKMLVPELNDAETMGAETSRFEELLLQASKELQQAQTSRPESTQIQPQPGFCIKTNSAEGKVFINICHSPSIPPPADLTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFFRRMQNSDFLRELVITIAREGLEDKYGLQLNPEWRILKNRPFLGSISQQNIRSQQRPRIQELGNLHTPSSPRPEAGPEKPHLSLWLEAPDLLLAEIDLPKLDGALGLSLEVGENRLVMGGPQQLYHLDTYIPLRINCDESKAAFHQKRKQLMVAMPLLSVPS", "length": 318, "header": "tr|A0AAF7ACE3-1|A0AAF7ACE3_BOVIN Isoform 1 of PIH1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=PIH1D1 PE=3 SV=1 CANONICAL=A0AAF7ACE3-1" }, "isoforms": [ { "isoform_ac": "A0AAF7ACE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3/entry", "sequence": { "sequence": "MLSASQPSLSQTFFHGLRGSLPEGTWRAMADSKMLVPELNDAETMGAETSRFEELLLQASKELQQAQTSRPESTQIQPQPGFCIKTNSAEGKVFINICHSPSIPPPADLTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFFRRMQNSDFLRELVITIAREGLEDKYGLQLNPEWRILKNRPFLGSISQQNIRSQQRPRIQELGNLHTPSSPRPEAGPEKPHLSLWLEAPDLLLAEIDLPKLDGALGLSLEVGENRLVMGGPQQLYHLDTYIPLRINCDESKAAFHQKRKQLMVAMPLLSVPS", "length": 318, "header": "tr|A0AAF7ACE3-1|A0AAF7ACE3_BOVIN Isoform 1 of PIH1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=PIH1D1 PE=3 SV=1 CANONICAL=A0AAF7ACE3-1" }, "locus": { "chromosome": "18", "start_pos": 55910440, "end_pos": 55903503, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077462.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077462.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066767.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066767.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "positive regulation of glucose mediated signaling pathway", "id": "GO:1902661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902661", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "box C/D snoRNP assembly", "id": "GO:0000492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000492", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "snoRNA localization", "id": "GO:0048254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048254", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "id": "GO:1901838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901838", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "TORC1 complex assembly", "id": "GO:1905669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905669", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "R2TP complex", "id": "GO:0097255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097255", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "pre-snoRNP complex", "id": "GO:0070761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070761", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" }, { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ACE3", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7ACE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" }, { "id": "PF08190", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08190" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIH1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 213, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF7ACE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACE3" }, { "id": "PF18201", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18201" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIH1D1/2/3 CS-like", "eco_id": "ECO_0000259", "start_pos": 243, "end_pos": 313, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF6Z4Z6-1", "uniprot_ac": "A0AAF6Z4Z6", "uniprot_id": "A0AAF6Z4Z6_BOVIN", "mass": { "chemical_mass": 12574.0, "monoisotopic_mass": 12574.0 }, "refseq": {}, "gene_names": [ { "name": "FXYD7", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6" } ] } ], "protein_names": [ { "name": "FXYD domain-containing ion transport regulator", "type": "recommended", "evidence": [ { "id": "A0AAF6Z4Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FXYD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6", "locus": { "chromosome": "18", "start_pos": 45877888, "end_pos": 45868746, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018326", "url": "https://www.ensembl.org/id/ENSBTAG00000018326" } ] } } ], "crossref": [ { "id": "A0AAF6Z4Z6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF6Z4Z6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14132:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14132:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6Z4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATQVPTKVPQDPDPFYYDYDTVQTVGMTLATILFLLGILIILSKCDPFLSFPRHLQFPYWLLSIPLCPVSLFCSLSLLTGKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV", "length": 115, "header": "tr|A0AAF6Z4Z6-1|A0AAF6Z4Z6_BOVIN Isoform 1 of FXYD domain-containing ion transport regulator OS=Bos taurus OX=9913 GN=FXYD7 PE=3 SV=1 CANONICAL=A0AAF6Z4Z6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6/entry", "sequence": { "sequence": "MATQVPTKVPQDPDPFYYDYDTVQTVGMTLATILFLLGILIILSKCDPFLSFPRHLQFPYWLLSIPLCPVSLFCSLSLLTGKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV", "length": 115, "header": "tr|A0AAF6Z4Z6-1|A0AAF6Z4Z6_BOVIN Isoform 1 of FXYD domain-containing ion transport regulator OS=Bos taurus OX=9913 GN=FXYD7 PE=3 SV=1 CANONICAL=A0AAF6Z4Z6-1" }, "locus": { "chromosome": "18", "start_pos": 45877434, "end_pos": 45868821, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024386.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024386.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024386.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024386.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "monoatomic ion transport", "id": "GO:0006811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006811", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6" } ], "pmid": "" }, { "name": "regulation of monoatomic ion transport", "id": "GO:0043269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043269", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ion channel regulator activity", "id": "GO:0099106", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099106", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4Z6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AP66-1", "uniprot_ac": "A0AAF7AP66", "uniprot_id": "A0AAF7AP66_BOVIN", "mass": { "chemical_mass": 93284.0, "monoisotopic_mass": 93284.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC8C", "type": "recommended", "evidence": [ { "id": "A0AAF7AP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66" } ] } ], "protein_names": [ { "name": "Volume-regulated anion channel subunit LRRC8C", "type": "recommended", "evidence": [ { "id": "A0AAF7AP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66/entry#names_and_taxonomy" } ] }, { "name": "Leucine-rich repeat-containing protein 8C", "type": "synonym", "evidence": [ { "id": "A0AAF7AP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC8C", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66", "locus": { "chromosome": "3", "start_pos": 53554083, "end_pos": 53649957, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000900", "url": "https://www.ensembl.org/id/ENSBTAG00000000900" } ] } } ], "crossref": [ { "id": "A0AAF7AP66", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AP66", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66320", "url": "https://www.rhea-db.org/rhea/66320", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66324", "url": "https://www.rhea-db.org/rhea/66324", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66328", "url": "https://www.rhea-db.org/rhea/66328", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SL63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AP66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLFKSRNMIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPSQNQSSVSNVSQAVASTTPLPPPKPSPSNPVTVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMSRSNTTQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLKEYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE", "length": 811, "header": "tr|A0AAF7AP66-1|A0AAF7AP66_BOVIN Isoform 1 of Volume-regulated anion channel subunit LRRC8C OS=Bos taurus OX=9913 GN=LRRC8C PE=3 SV=1 CANONICAL=A0AAF7AP66-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL63/entry", "sequence": { "sequence": "MQDKIICLPKRVQPSQNQSSVSNVSQAVASTTPLPPPKPSPSNPVTVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMSRSNTTQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLKEYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE", "length": 756, "header": "tr|A0AAA9SL63-1|A0AAF7AP66_BOVIN Computationally mapped isoform of Volume-regulated anion channel subunit LRRC8C OS=Bos taurus OX=9913 GN=LRRC8C PE=3 SV=1 CANONICAL=A0AAF7AP66-1" }, "locus": { "chromosome": "3", "start_pos": 53557789, "end_pos": 53555522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094860.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094860.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085927.1" } ] } }, { "isoform_ac": "A0AAF7AP66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66/entry", "sequence": { "sequence": "MSLFKSRNMIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPSQNQSSVSNVSQAVASTTPLPPPKPSPSNPVTVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMSRSNTTQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLKEYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE", "length": 811, "header": "tr|A0AAF7AP66-1|A0AAF7AP66_BOVIN Isoform 1 of Volume-regulated anion channel subunit LRRC8C OS=Bos taurus OX=9913 GN=LRRC8C PE=3 SV=1 CANONICAL=A0AAF7AP66-1" }, "locus": { "chromosome": "3", "start_pos": 53649808, "end_pos": 53555522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085971.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085971.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072625.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072625.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "monoatomic ion transmembrane transport", "id": "GO:0034220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034220", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP66", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 540, "end_pos": 542, "annotation": "n_glycosylation_sequon" }, { "start_pos": 560, "end_pos": 562, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29823", "name": "", "equation": "chloride(in) = chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN01-1", "Q5E9B7-1", "Q9XSA7-1", "P35071-1", "P35526-1" ], "evidence": [ { "id": "29823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29823" } ] }, { "id": "66320", "name": "", "equation": "2',3'-cGAMP(out) = 2',3'-cGAMP(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "66320", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66320" } ] }, { "id": "66324", "name": "", "equation": "iodide(out) = iodide(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B7-1", "Q9XSA7-1" ], "evidence": [ { "id": "66324", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66324" } ] }, { "id": "66328", "name": "", "equation": "taurine(out) = taurine(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "66328", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66328" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] }, { "uniprot_ac": "Q5E9B7", "gene_name": "CLIC1", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] } ] }, { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP66" }, { "id": "PF12534", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12534" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRC8 pannexin-like TM region", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 346, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 200, "end_pos": 202 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 313, "end_pos": 315 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 540, "end_pos": 542 }, { "start_pos": 560, "end_pos": 562 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0S1-1", "uniprot_ac": "F1N0S1", "uniprot_id": "F1N0S1_BOVIN", "mass": { "chemical_mass": 98004.0, "monoisotopic_mass": 98004.0 }, "refseq": {}, "gene_names": [ { "name": "ASAP3", "type": "recommended", "evidence": [ { "id": "F1N0S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ] } ], "protein_names": [ { "name": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "F1N0S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S1/entry#names_and_taxonomy" } ] }, { "name": "Development and differentiation-enhancing factor-like 1", "type": "synonym", "evidence": [ { "id": "F1N0S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Promotes cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N7N1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7N1#function" }, { "database": "UniProtKB", "id": "ARBA00054302", "url": "https://www.uniprot.org/uniprotkb/ARBA00054302#function" }, { "database": "UniProtKB", "id": "A0AAA9RSA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSA9#function" }, { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASAP3", "url": "https://www.uniprot.org/uniprotkb/F1N0S1", "locus": { "chromosome": "2", "start_pos": 129418172, "end_pos": 129367157, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012263", "url": "https://www.ensembl.org/id/ENSBTAG00000012263" } ] } } ], "crossref": [ { "id": "F1N0S1", "url": "https://alphafold.ebi.ac.uk/entry/F1N0S1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012263", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012263", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07640", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07640", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13251", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13251", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17900", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17900", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N7N1", "url": "https://www.orthodb.org/?gene=A0A3Q1N7N1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0S1", "url": "https://www.orthodb.org/?gene=F1N0S1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45854", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45854", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45854:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45854:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16746", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16746", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N7N1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7N1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7N1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0S1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPRALGARPRRPHLAPAMPEQLSVAEFLAVTAEDLSSPAGAAAFAAKMPRCRGAALAREEMLEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDTLLKGQLRDGRQDSKKQLEKAWKDYEAKMARLEKERDRARVIGGSTGEVAQDTQRERRVFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGLKAAQSLSPFIEKLAVSVHTLRQAQEEELQKLTQLRDSLRGTLQLESREQQESLSRKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPGSGPGPWGAAGLDGEPQDLTKLLIAEVKSRPGNGQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRIQSLTLDLLGPSELLLALNIGNTRFNEVMEAQLPSHGGPKPSAESDMSARRDYIVAKYVEHRFARRSTPEPQRLCTAICNRDLLSVLEAFANGQDFGQPLPGPEGQAPGELALHLAVRVANQASLPLVDFIIQNGGHLDAKAADGNSALHCAVFYNQLDCLKLLLKGRASVATVNEAGETALDIARRKQHKECENLLEQAQAGTLTFPLHLDYAWGISTEPGSDSEEDEEEKRCALKPPAQARWTSGRLDISNKTYETITSLGPAAPKSQSEDCPPPLPVKNLSRTMAQGRVGHASGDRSEIPSLSSESLGASENLSSPASSSSSLTSPVEPGGPNETLPSSEEGPCEPQGPSRPSLTSGISPAEMYPPVRFSSESTRSYRRGGGAWKSVAQPGSLYPEGT", "length": 898, "header": "tr|F1N0S1-1|F1N0S1_BOVIN Isoform 1 of Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ASAP3 PE=4 SV=5 CANONICAL=F1N0S1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N7N1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7N1/entry", "sequence": { "sequence": "MGPRALGARMLEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDTLLKGQLRDGRQDSKKQLEKAWKDYEAKMARLEKERDRARVIGGSTGEVAQDTQRERRVFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGLKAAQSLSPFIEKLAVSVHTLRQAQEEELQKLTQLRDSLRGTLQLESREESLSRKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPGSGPGPWGAAGLDGEPQDLTKLLIAEVKSRPGNGQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRIQSLTLDLLGPSELLLALNIGNTRFNEVMEAQLPSHGGPKPSAESDMSARRDYIVAKYVEHRFARRSTPEPQRLCTAICNRDLLSVLEAFANGQDFGQPLPGPEGQAPGELALHLAVRVANQASLPLVDFIIQNGGHLDAKAADGNSALHCAVFYNQLDCLKLLLKGRASVATVNEAGETALDIARRKQHKECENLLEQAQAGTLTFPLHLDYAWGISTEPGSDSEEDEEEKRCALKPPAQARWTSGRLDISNKTYETITSLGPAAPKSQSEDCPPPLPVKNLSRTMAQGRVGHASGDRSEIPSLSSESLGASENLSSPASSSSSLTSPVEPGGPNETLPSSEEGPCEPQGPSRPSLTSGISPAEMYPPVRFSSESTRSYRRGGGAWKSVAQPGSLYPEGT", "length": 844, "header": "tr|A0A3Q1N7N1-1|F1N0S1_BOVIN Computationally mapped isoform of Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ASAP3 PE=4 SV=3 CANONICAL=F1N0S1-1" }, "locus": { "chromosome": "2", "start_pos": 129415692, "end_pos": 129367309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077197.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077197.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066789.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066789.3" } ] } }, { "isoform_ac": "A0AAA9RSA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSA9/entry", "sequence": { "sequence": "MSAGGETEMLEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDTLLKGQLRDGRQDSKKQLEKAWKDYEAKMARLEKERDRARVIGGSTGEVAQDTQRERRVFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGLKAAQSLSPFIEKLAVSVHTLRQAQEEELQKLTQLRDSLRGTLQLESREESLSRKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPGSGPGPWGAAGLDGEPQDLTKLLIAEVKSRPGNGQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRIQSLTLDLLGPSELLLALNIGNTRFNEVMEAQLPSHGGPKPSAESDMSARRDYIVAKYVEHRFARRSTPEPQRLCTAICNRDLLSVLEAFANGQDFGQPLPGPEGQAPGELALHLAVRVANQASLPLVDFIIQNGGHLDAKAADGNSALHCAVFYNQLDCLKLLLKGRASVATVNEAGETALDIARRKQHKECENLLEQAQAGTLTFPLHLDYAWGISTEPGSDSEEDEEEKRCALKPPAQARWTSGRLDISNKTYETITSLGPAAPKSQSEDCPPPLPVKNLSRTMAQGRVGHASGDRSEIPSLSSESLGASENLSSPASSSSSLTSPVEPGGPNETLPSSEEGPCEPQGPSRPSLTSGISPAEMYPPVRFSSESTRSYRRGGGAWKSVAQPGSLYPEGT", "length": 843, "header": "tr|A0AAA9RSA9-1|F1N0S1_BOVIN Computationally mapped isoform of Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ASAP3 PE=4 SV=1 CANONICAL=F1N0S1-1" }, "locus": { "chromosome": "2", "start_pos": 129415692, "end_pos": 129381136, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115729.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115729.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075391.1" } ] } }, { "isoform_ac": "F1N0S1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1/entry", "sequence": { "sequence": "MGPRALGARPRRPHLAPAMPEQLSVAEFLAVTAEDLSSPAGAAAFAAKMPRCRGAALAREEMLEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLVQNLNNIVSFPLDTLLKGQLRDGRQDSKKQLEKAWKDYEAKMARLEKERDRARVIGGSTGEVAQDTQRERRVFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGLKAAQSLSPFIEKLAVSVHTLRQAQEEELQKLTQLRDSLRGTLQLESREQQESLSRKNSGGGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPGSGPGPWGAAGLDGEPQDLTKLLIAEVKSRPGNGQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRIQSLTLDLLGPSELLLALNIGNTRFNEVMEAQLPSHGGPKPSAESDMSARRDYIVAKYVEHRFARRSTPEPQRLCTAICNRDLLSVLEAFANGQDFGQPLPGPEGQAPGELALHLAVRVANQASLPLVDFIIQNGGHLDAKAADGNSALHCAVFYNQLDCLKLLLKGRASVATVNEAGETALDIARRKQHKECENLLEQAQAGTLTFPLHLDYAWGISTEPGSDSEEDEEEKRCALKPPAQARWTSGRLDISNKTYETITSLGPAAPKSQSEDCPPPLPVKNLSRTMAQGRVGHASGDRSEIPSLSSESLGASENLSSPASSSSSLTSPVEPGGPNETLPSSEEGPCEPQGPSRPSLTSGISPAEMYPPVRFSSESTRSYRRGGGAWKSVAQPGSLYPEGT", "length": 898, "header": "tr|F1N0S1-1|F1N0S1_BOVIN Isoform 1 of Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ASAP3 PE=4 SV=5 CANONICAL=F1N0S1-1" }, "locus": { "chromosome": "2", "start_pos": 129415692, "end_pos": 129367309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016266.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016266.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016266.8", "url": "https://www.ensembl.org/id/ENSBTAP00000016266.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" }, { "name": "regulation of stress fiber assembly", "id": "GO:0051492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051492", "evidence": [ { "database": "UniProtKB", "id": "F1N0S1", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 750, "end_pos": 752, "annotation": "n_glycosylation_sequon" }, { "start_pos": 779, "end_pos": 781, "annotation": "n_glycosylation_sequon" }, { "start_pos": 812, "end_pos": 814, "annotation": "n_glycosylation_sequon" }, { "start_pos": 833, "end_pos": 835, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0S1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 898, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0S1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0S1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" }, { "id": "PS50115", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arf-GAP", "eco_id": "ECO_0000259", "start_pos": 446, "end_pos": 568, "start_aa": "Lys", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S1" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 322, "end_pos": 414, "start_aa": "Gly", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 389, "end_pos": 391 }, { "start_pos": 750, "end_pos": 752 }, { "start_pos": 779, "end_pos": 781 }, { "start_pos": 812, "end_pos": 814 }, { "start_pos": 833, "end_pos": 835 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N064-1", "uniprot_ac": "F1N064", "uniprot_id": "F1N064_BOVIN", "mass": { "chemical_mass": 58026.0, "monoisotopic_mass": 58026.0 }, "refseq": {}, "gene_names": [ { "name": "ETV3", "type": "recommended", "evidence": [ { "id": "F1N064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ] } ], "protein_names": [ { "name": "ETS translocation variant 3", "type": "recommended", "evidence": [ { "id": "F1N064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N064/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NFR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFR3#function" }, { "database": "UniProtKB", "id": "ARBA00025214", "url": "https://www.uniprot.org/uniprotkb/ARBA00025214#function" }, { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETV3", "url": "https://www.uniprot.org/uniprotkb/F1N064", "locus": { "chromosome": "3", "start_pos": 13743098, "end_pos": 13730577, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008649", "url": "https://www.ensembl.org/id/ENSBTAG00000008649" } ] } } ], "crossref": [ { "id": "F1N064", "url": "https://alphafold.ebi.ac.uk/entry/F1N064", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008649", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008649", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538995", "url": "https://www.ncbi.nlm.nih.gov/gene/538995", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538995", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538995", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NFR3", "url": "https://www.orthodb.org/?gene=A0A3Q1NFR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N064", "url": "https://www.orthodb.org/?gene=F1N064", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NFR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N064-1", "url": "https://www.uniprot.org/uniprotkb/F1N064-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNGRNPSRRVKMKAGCSVVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTGSSRFHFPPLDTHSPTSDVQPGRFSASSLTASGQESSNGIDRKVELSELEDGPAADWRRGVDLMSSRSAVGGGIGHQKRKPDIMLPLFSRPGMYPDPHSPFAVSPIPGRGGVLHVPVSPALPLTPTIFSYSPSPGLSPFTSSSRFSFSPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQAHPEEPSQFSIKLQPPPIGRKNRERVESSEEAAPVPVPTLTPVPPRIKVEPALEKAPESLRQSAREKEERSQEEGTVPGRTTEEEKSTIFARPAAPPVWPSVPISTPSEEPLEVSEDSEDRPGKEPGAPEKKEDALMPPKLRLKRRWNDDPEALSKNGKFLWNGSGPRGLATAAADA", "length": 521, "header": "tr|F1N064-1|F1N064_BOVIN Isoform 1 of ETS translocation variant 3 OS=Bos taurus OX=9913 GN=ETV3 PE=3 SV=4 CANONICAL=F1N064-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NFR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFR3/entry", "sequence": { "sequence": "MKAGCSVVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTGSSRFHFPPLDTHSPTSDVQPGRFSASSLTASGQESSNGIDRKVELSELEDGPAADWRRGVDLMSSRSAVGGGIGHQKRKPDIMLPLFSRPGMYPDPHSPFAVSPIPGRGGVLHVPVSPALPLTPTIFSYSPSPGLSPFTSSSRFSFSPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQAHPEEPSQFSIKLQPPPIGRKNRERVESSEEAAPVPVPTLTPVPPRIKVEPALEKAPESLRQSAREKEERSQEEGTVPGRTTEEEKSTIFARPAAPPVWPSVPISTPSEEPLEVSEDSEDRPGKEPGAPEKKEDALMPPKLRLKRRWNDDPEALSKNGKFLWNGSGPRGLATAAADA", "length": 509, "header": "tr|A0A3Q1NFR3-1|F1N064_BOVIN Computationally mapped isoform of ETS translocation variant 3 OS=Bos taurus OX=9913 GN=ETV3 PE=3 SV=3 CANONICAL=F1N064-1" }, "locus": { "chromosome": "3", "start_pos": 13742094, "end_pos": 13732606, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078485.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078485.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070528.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070528.3" } ] } }, { "isoform_ac": "F1N064-1", "url": "https://www.uniprot.org/uniprotkb/F1N064/entry", "sequence": { "sequence": "MGNGRNPSRRVKMKAGCSVVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTGSSRFHFPPLDTHSPTSDVQPGRFSASSLTASGQESSNGIDRKVELSELEDGPAADWRRGVDLMSSRSAVGGGIGHQKRKPDIMLPLFSRPGMYPDPHSPFAVSPIPGRGGVLHVPVSPALPLTPTIFSYSPSPGLSPFTSSSRFSFSPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQAHPEEPSQFSIKLQPPPIGRKNRERVESSEEAAPVPVPTLTPVPPRIKVEPALEKAPESLRQSAREKEERSQEEGTVPGRTTEEEKSTIFARPAAPPVWPSVPISTPSEEPLEVSEDSEDRPGKEPGAPEKKEDALMPPKLRLKRRWNDDPEALSKNGKFLWNGSGPRGLATAAADA", "length": 521, "header": "tr|F1N064-1|F1N064_BOVIN Isoform 1 of ETS translocation variant 3 OS=Bos taurus OX=9913 GN=ETV3 PE=3 SV=4 CANONICAL=F1N064-1" }, "locus": { "chromosome": "3", "start_pos": 13742094, "end_pos": 13730956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011404.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011404.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011404.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011404.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538995", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538995", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "RNA polymerase II transcription repressor complex", "id": "GO:0090571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090571", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "cellular response to granulocyte macrophage colony-stimulating factor stimulus", "id": "GO:0097011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097011", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" }, { "name": "DEAD/H-box RNA helicase binding", "id": "GO:0017151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017151", "evidence": [ { "database": "UniProtKB", "id": "F1N064", "url": "https://www.uniprot.org/uniprotkb/F1N064" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 507, "end_pos": 509, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N064" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 128, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 507, "end_pos": 509 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N155-1", "uniprot_ac": "F1N155", "uniprot_id": "F1N155_BOVIN", "mass": { "chemical_mass": 69314.0, "monoisotopic_mass": 69314.0 }, "refseq": { "ac": "XP_024853672", "name": "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853672" }, "gene_names": [ { "name": "CLPX", "type": "recommended", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "name": "CLPX", "type": "synonym", "evidence": [ { "id": "XP_024853672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853672" } ] } ], "protein_names": [ { "name": "ATP-dependent clpX-like chaperone, mitochondrial", "type": "recommended", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.10", "type": "synonym", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024853672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853672" } ] }, { "name": "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "type": "synonym", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NHS6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHS6#function" }, { "database": "UniProtKB", "id": "ARBA00058714", "url": "https://www.uniprot.org/uniprotkb/ARBA00058714#function" }, { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLPX", "url": "https://www.uniprot.org/uniprotkb/F1N155", "locus": { "chromosome": "10", "start_pos": 12093199, "end_pos": 12129491, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008386", "url": "https://www.ensembl.org/id/ENSBTAG00000008386" } ] } } ], "crossref": [ { "id": "F1N155", "url": "https://alphafold.ebi.ac.uk/entry/F1N155", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008386", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008386", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19497", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19497", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100138870", "url": "https://www.ncbi.nlm.nih.gov/gene/100138870", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138870", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138870", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NHS6", "url": "https://www.orthodb.org/?gene=A0A3Q1NHS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N155", "url": "https://www.orthodb.org/?gene=F1N155", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48102:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48102:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07724", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07724", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26040", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26040", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024853672", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853672", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NHS6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NHS6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N155-1", "url": "https://www.uniprot.org/uniprotkb/F1N155-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGCGACTCGAAAARIFSSSLVSAQRGISCSRIHIPVLGRLGTFETQLLRRAPFRAFTETPAYFASRDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASVQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS", "length": 633, "header": "tr|F1N155-1|F1N155_BOVIN Isoform 1 of ATP-dependent clpX-like chaperone, mitochondrial OS=Bos taurus OX=9913 GN=CLPX PE=4 SV=2 CANONICAL=F1N155-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NHS6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHS6/entry", "sequence": { "sequence": "MSGCGACTCGAAAARIFSSSLVSAQRGISCSRIHIPVLGRLGTFETQLLRRAPFRAFTETPAYFASRDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELLQIAGISPHGNALGASVQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS", "length": 619, "header": "tr|A0A3Q1NHS6-1|F1N155_BOVIN Computationally mapped isoform of ATP-dependent clpX-like chaperone, mitochondrial OS=Bos taurus OX=9913 GN=CLPX PE=4 SV=2 CANONICAL=F1N155-1" }, "locus": { "chromosome": "10", "start_pos": 12129292, "end_pos": 12094203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078764.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078764.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071529.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071529.2" } ] } }, { "isoform_ac": "F1N155-1", "url": "https://www.uniprot.org/uniprotkb/F1N155/entry", "sequence": { "sequence": "MSGCGACTCGAAAARIFSSSLVSAQRGISCSRIHIPVLGRLGTFETQLLRRAPFRAFTETPAYFASRDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASVQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS", "length": 633, "header": "tr|F1N155-1|F1N155_BOVIN Isoform 1 of ATP-dependent clpX-like chaperone, mitochondrial OS=Bos taurus OX=9913 GN=CLPX PE=4 SV=2 CANONICAL=F1N155-1" }, "locus": { "chromosome": "10", "start_pos": 12129292, "end_pos": 12094203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011038.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011038.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011038.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011038.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100138870", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138870", "resource": "KEGG Pathway" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "peptidase activator activity", "id": "GO:0016504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016504", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "ATP-dependent peptidase activity", "id": "GO:0004176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004176", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "mitochondrial endopeptidase Clp complex", "id": "GO:0009841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009841", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ATP metabolic process", "id": "GO:0046034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046034", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" }, { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "F1N155", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-9838035", "name": "CLPXP binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838035", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838035" } ] }, { "id": "R-BTA-9838289", "name": "CLPXP degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838289", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838289" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LS03", "gene_name": "", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1LYU1", "gene_name": "PDK1", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1LYU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLI6", "gene_name": "ALAS1", "activity": [ { "ec_number": "2.3.1.37", "activity": "succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA.", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] }, { "ec_number": "2.3.1.37", "activity": "", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7MB35", "gene_name": "PDHA1", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MTT7", "gene_name": "ECI1", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MXW5", "gene_name": "OXSM", "activity": [ { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2.", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N206", "gene_name": "DLD", "activity": [ { "ec_number": "1.8.1.4", "activity": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+).", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N338", "gene_name": "HADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MWN1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N0R5", "gene_name": "HSPD1", "activity": [ { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P00829", "gene_name": "ATP5F1B", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out).", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P11966", "gene_name": "PDHB", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P20000", "gene_name": "ALDH2", "activity": [ { "ec_number": "1.2.1.3", "activity": "acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+).", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] } ] }, { "uniprot_ac": "P20004", "gene_name": "ACO2", "activity": [ { "ec_number": "4.2.1.3", "activity": "citrate = D-threo-isocitrate.", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] }, { "ec_number": "4.2.1.3", "activity": "", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] } ] }, { "uniprot_ac": "P22600", "gene_name": "FECH", "activity": [ { "ec_number": "4.98.1.1", "activity": "heme b + 2 H(+) = protoporphyrin IX + Fe(2+).", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] }, { "ec_number": "4.98.1.1", "activity": "", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q02337", "gene_name": "BDH1", "activity": [ { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] }, { "ec_number": "1.1.1.30", "activity": "", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] } ] }, { "uniprot_ac": "Q04467", "gene_name": "IDH2", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "Q04467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q04467" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "Q04467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q04467" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0NXR6", "gene_name": "ACAD8", "activity": [ { "ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q148N0", "gene_name": "OGDH", "activity": [ { "ec_number": "1.2.4.2", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29RK1", "gene_name": "CS", "activity": [ { "ec_number": "2.3.3.1", "activity": "oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+).", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] }, { "ec_number": "2.3.3.1", "activity": "", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] } ] }, { "uniprot_ac": "Q29RZ0", "gene_name": "ACAT1", "activity": [ { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] }, { "ec_number": "2.3.1.9", "activity": "", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KHU4", "gene_name": "CLPP", "activity": [ { "ec_number": "3.4.21.92", "activity": "Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).", "evidence": [ { "id": "Q2KHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU4" } ] }, { "ec_number": "3.4.21.92", "activity": "", "evidence": [ { "id": "Q2KHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU4" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q32LG3", "gene_name": "MDH2", "activity": [ { "ec_number": "1.1.1.37", "activity": "(S)-malate + NAD(+) = oxaloacetate + NADH + H(+).", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] }, { "ec_number": "1.1.1.37", "activity": "", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3MHX5", "gene_name": "SUCLG2", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] }, { "ec_number": "6.2.1.4", "activity": "itaconate + GTP + CoA = itaconyl-CoA + GDP + phosphate.", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] }, { "ec_number": "6.2.1.4", "activity": "", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N155-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 633, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N155-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N155" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" }, { "id": "PS51902", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51902" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ClpX-type ZB", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 146, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.4.10", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.10", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10" }, { "id": "3.6.4.10", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.10" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 461, "end_pos": 463 }, { "start_pos": 541, "end_pos": 543 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0M7-1", "uniprot_ac": "F1N0M7", "uniprot_id": "F1N0M7_BOVIN", "mass": { "chemical_mass": 114243.0, "monoisotopic_mass": 114243.0 }, "refseq": { "ac": "XP_024847593", "name": "beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847593" }, "gene_names": [ { "name": "B4GALNT3", "type": "recommended", "evidence": [ { "id": "F1N0M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ] }, { "name": "B4GALNT3", "type": "synonym", "evidence": [ { "id": "XP_024847593", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847593" } ] } ], "protein_names": [ { "name": "Beta-1,4-N-acetylgalactosaminyltransferase", "type": "recommended", "evidence": [ { "id": "F1N0M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M7/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.244", "type": "synonym", "evidence": [ { "id": "F1N0M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M7/entry#names_and_taxonomy" } ] }, { "name": "beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024847593", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847593" } ] } ], "function": [ { "annotation": "Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2E0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E0#function" }, { "database": "UniProtKB", "id": "RU364016", "url": "https://www.uniprot.org/uniprotkb/RU364016#function" }, { "database": "UniProtKB", "id": "F1N0M7", "url": "https://www.uniprot.org/uniprotkb/F1N0M7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0M7", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "B4GALNT3", "url": "https://www.uniprot.org/uniprotkb/F1N0M7", "locus": { "chromosome": "5", "start_pos": 107434016, "end_pos": 107337704, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008553", "url": "https://www.ensembl.org/id/ENSBTAG00000008553" } ] } } ], "crossref": [ { "id": "F1N0M7", "url": "https://alphafold.ebi.ac.uk/entry/F1N0M7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008553", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008553", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527026", "url": "https://www.ncbi.nlm.nih.gov/gene/527026", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VDPHLQF", "url": "https://omabrowser.org/oma/group/VDPHLQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0M7", "url": "https://www.orthodb.org/?gene=F1N0M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12369:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12369:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07691", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07691", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024847593", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847593", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20493", "url": "https://www.rhea-db.org/rhea/20493", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S2E0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2E0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0M7", "url": "https://www.uniprot.org/uniprotkb/F1N0M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0M7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0M7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGPRAARLRLLLRPVKLLRRRFRLLLLLAVVSVGLWTLYLELAASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPNLQFYRPQRLGPKDPGSARGGSGNSSYLKWNKPVPWLSEFRGRVNLHVFEDWCGSSVQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGEIQFAIAADDNAEFWLSRDDQVSGLRLLASVGKTGKEWTAPGEFAKFRSQISKPVSLAAARRYYFEVLHKQNDQGTDHVEVAWRRNDPGAKFSIIDSASLSLFTNETLLRMDEVDHIPQTAASHVRSPDPLPTDEQPPVDMLRPDPRDALYRVPLIPKAQLRHVLPDCPYKPSYLVDGLPLQRYQGLRFIHLSFVYPNDYTRLSHMETQNKCFYQENAYYQDRLSFQDYIKIDQPQKQGPEQPAGFEDGLLEESQYGEAAEDTPAPDGQNARMPVGKSGPPTAPRKDAPDRRLRNLRRLLARAQEGLAAPPPWQNSTASLPVRPSTTPAQPADKKARKPSLKPHQAPQHPDKWPPGPLAGHSPPAKRPRPAGASPGKMLGRSQWLNQVESYIAEQRRGDRMEPPDPRRGWPEDQDVVVAGAGQEGQTEGEAEGEDEGEDEEDVSEVLEYLSMFDPVVNWEQTFSAHDLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRIRGRYQLQRIVNIEKRQDHLRGGRYLLELELLEQGQRLVRLSEFVSTRGWQGADAVGGKEAEALNLQGLVWSPHDFQRHGPGARAPEPKLCWPQGFSWNHRAVVHFIVPVKNQARWVQQFIRDMETLSQVTSDPHFNIIITDYSSEDMDIETALKQSKLRSYQYMKLSGNFERSAGLQAGVDLVKDPHSIIFLCDLHIHFPAGIIDTIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLEVERLSLRNFFHYFHSKRGMWNRRQMKTP", "length": 1003, "header": "tr|F1N0M7-1|F1N0M7_BOVIN Isoform 1 of Beta-1,4-N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=B4GALNT3 PE=3 SV=3 CANONICAL=F1N0M7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2E0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E0/entry", "sequence": { "sequence": "MREDEDRGSAQAVHCALMGEEVTTFPREGYGSWRELAKALASRNIPAVDPNLQFYRPQRLGPKDPGSARGGSGNSSYLKWNKPVPWLSEFRGRVNLHVFEDWCGSSVQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGEIQFAIAADDNAEFWLSRDDQVSGLRLLASVGKTGKEWTAPGEFAKFRSQISKPVSLAAARRYYFEVLHKQNDQGTDHVEVAWRRNDPGAKFSIIDSASLSLFTNETLLRMDEVDHIPQTAASHVRSPDPLPTDEQPPVDMLRPDPRDALYRVPLIPKAQLRHVLPDCPYKPSYLVDGLPLQRYQGLRFIHLSFVYPNDYTRLSHMETQNKCFYQENAYYQDRLSFQDYIKIDQPQKQGPEQPAGFEDGLLEESQYGEAAEDTPAPDGQNARMPVGKSGPPTAPRKDAPDRRLRNLRRLLARAQEGLAAPPPWQNSTASLPVRPSTTPAQPADKKARKPSLKPHQAPQHPDKWPPGPLAGHSPPAKRPRPAGASPGKMLGRSQWLNQVESYIAEQRRGDRMEPPDPRRGWPEDQDVVVAGAGQEGQTEGEAEGEDEGEDEEDVSEVLEYLSMFDPVVNWEQTFSAHDLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRIRGRYQLQRIVNIEKRQDHLRGGRYLLELELLEQGQRLVRLSEFVSTRGWQGADAVGGKEAEALNLQGLVWSPHDFQRHGPGARAPEPKLCWPQGFSWNHRAVVHFIVPVKNQARWVQQFIRDMETLSQVTSDPHFNIIITDYSSEDMDIETALKQSKLRSYQYMKLSGNFERSAGLQAGVDLVKDPHSIIFLCDLHIHFPAGIIDTIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLEVERLSLRNFFHYFHSKRGMWNRRQMKTP", "length": 975, "header": "tr|A0AAA9S2E0-1|F1N0M7_BOVIN Computationally mapped isoform of Beta-1,4-N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=B4GALNT3 PE=3 SV=1 CANONICAL=F1N0M7-1" }, "locus": { "chromosome": "5", "start_pos": 107433580, "end_pos": 107360842, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105353.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105353.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079204.1" } ] } }, { "isoform_ac": "F1N0M7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0M7/entry", "sequence": { "sequence": "MGGPRAARLRLLLRPVKLLRRRFRLLLLLAVVSVGLWTLYLELAASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPNLQFYRPQRLGPKDPGSARGGSGNSSYLKWNKPVPWLSEFRGRVNLHVFEDWCGSSVQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGEIQFAIAADDNAEFWLSRDDQVSGLRLLASVGKTGKEWTAPGEFAKFRSQISKPVSLAAARRYYFEVLHKQNDQGTDHVEVAWRRNDPGAKFSIIDSASLSLFTNETLLRMDEVDHIPQTAASHVRSPDPLPTDEQPPVDMLRPDPRDALYRVPLIPKAQLRHVLPDCPYKPSYLVDGLPLQRYQGLRFIHLSFVYPNDYTRLSHMETQNKCFYQENAYYQDRLSFQDYIKIDQPQKQGPEQPAGFEDGLLEESQYGEAAEDTPAPDGQNARMPVGKSGPPTAPRKDAPDRRLRNLRRLLARAQEGLAAPPPWQNSTASLPVRPSTTPAQPADKKARKPSLKPHQAPQHPDKWPPGPLAGHSPPAKRPRPAGASPGKMLGRSQWLNQVESYIAEQRRGDRMEPPDPRRGWPEDQDVVVAGAGQEGQTEGEAEGEDEGEDEEDVSEVLEYLSMFDPVVNWEQTFSAHDLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRIRGRYQLQRIVNIEKRQDHLRGGRYLLELELLEQGQRLVRLSEFVSTRGWQGADAVGGKEAEALNLQGLVWSPHDFQRHGPGARAPEPKLCWPQGFSWNHRAVVHFIVPVKNQARWVQQFIRDMETLSQVTSDPHFNIIITDYSSEDMDIETALKQSKLRSYQYMKLSGNFERSAGLQAGVDLVKDPHSIIFLCDLHIHFPAGIIDTIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLEVERLSLRNFFHYFHSKRGMWNRRQMKTP", "length": 1003, "header": "tr|F1N0M7-1|F1N0M7_BOVIN Isoform 1 of Beta-1,4-N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=B4GALNT3 PE=3 SV=3 CANONICAL=F1N0M7-1" }, "locus": { "chromosome": "5", "start_pos": 107433580, "end_pos": 107337757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011275.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011275.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011275.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011275.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1M021-1", "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase", "gene_name": "B4galnt3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGRPAGHSAMGSPRVALLMLLLRPIKLLRRRFRLLLLLAVVSVGLWTLYLELVASAQVGGNPLNHRYSSWRELAKALASRNIPAVDPNLQFYRPQQPSLKDQGIARSRSRNSSYLKWNKPVPWLSEFQGHANLHVFEDWCGSSIQQLRSNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSRDDQVSGLQLLASVGKTGKEWTAPGEFGKFQSQISKPVSLSASLRYYFEVLHKQNDEGTDHVEVAWRRNDPGAMFTIIDSPYLSLFTNETILRMDEVGHIPQTAASHVGSPNSPPQDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQESAYDQDRSGFQEYIKMDTPGKQGPEQPAGLEDGLLEESQYEEAPGEIPTSRDRNAGTQGRKQKTTSAPGLGVTDYHLRKLLARTQNGPLAPLSKQNSTATFPSRTKDNPVRQPEKRTGKTSPMPSRDLGDKVARRNLPVIQRARPTGDGPGKTLEQSQWLNQVESFIAEQRRGDRMEPPTPSRGWHAQEDVVIAADQEGEVEEEEEGEDEEEDMNEVFEYVPVFDPVVNWGQTFSAQNLDFQALRTDWIDLNCNTSGNLLLPEQEALEVTRVFLRKLSQRTRGRYQLQRIVNVEKRQDRLRGGRYLLELELLEGQRLVRLSEYVSTRGWRGGDPAGREDTEARNLQGLVWSPRSHHRQVSNAQDPEPKLCWPQGFSWNHRAVVHFIVPVKNQARWVQQFIRDMESLSQVTGDSRFSVIVTDYSSEDMNVEMALKRSRLRSYQYLKLNGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGIIDTIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDKIGGMNTKEFRDRWGGEDWELLDRILQAGLEVERLSLRNFFHHFHSKRGMWNRRQMKMP", "length": 999 }, "evidence": [ { "id": "F1N0M7", "url": "https://omabrowser.org/oma/group/F1N0M7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QYH1-1", "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase", "gene_name": "b4galnt3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMLNFLPVRKFKRNGRYIVFGAVLTVALLAAYLEFRATNEWSSSEVTIRGESVVWAKAAAAQRSVKEDHFSENQEKDKWTPKNTQQTWRTEYKGQANLHVFDDWCGSSIAQLRKNLHYPLYPHSRTTVKKLAVSPSWTNYGLRIFGYIHPYTDGDFLFALASDDNSEFWLSDDDNPDNLKLIAYVGKTGREWTAPGEYGKYASQISDLVPLQANKKYFFELIHKQNGEGTDHVEVAWQLKVTGSGFAIIDSKFISLYTNESSLRAGDVSHIPQTAASHVTPPPRSLQTPPHGVDMLRPDPRDSFHQIPLLDQVRLHGVLPDCIYNPSYIIKGYPLVRYQGLQFVYLTYVYPNDYTRLTHMESENKCFYRANPYYMERYGFSNYIQMDVPEKEELSLKFKGDSMFGKAANIGRNKDKDFQKSRENGEKQQIDGMEKKKKVLSDYGDDYDDYSMNRRRKLFSVQKHSVIRRKRNDGELNIRNEQENQPKEIQKLPEEAHNEPQPRRKKKRRLPQQQNLEDQQHPQNAPSEVKSYNQGVKQAYTVDKIPEQQNPERFQEKTQRRFKEKHLQADGSMVKNDRIHRLKAHYVNSSNVNPNPAIVRDVPIEKVREAIDLKEKSIKKPAMLNEVEIEHPESNGMDNRKVFLGEHVYKARKNSSNVVELKKHRVKNATYEYLHGGEVKADAMKKPKYREQKVDRVVVVDNRIVEYNNKAHNNIAVLQKPHQNMLYNQTSEHKDQAFNNRWGHANEDRNGVEKPIQDNAMHVKETEDNGDEEDAWVNQGLSEEEDYELVHRPAFDVEVKWNQTFHAKLLDLHSMRSDWIDLKCNVSGNLMLSESEALSVVDAFMKELNKKYPRQFSLDRIVNVEKKPDYNRGSRYLLELDLLEASGRHLRLGQYVFVKRTDDWGSQRKQKPQDTKLQLCNPYTFYWNPTATVHFIIPVKNQARWVKQFISDMEEIYRITGDQNFNIIITDYESTDMNIEEELLNSYIPRYQYLRLSGNFERSAGLQAGIDLITDDNSIVFLCDLHIHFPPGFIDTVRKHCVERRMAFAPIVMRLNCGATPQEPDGYWEVNGFGLLGIYKSDLDRIGGMNTKEFTDRWGGEDWELLDRILQGGLEVERLYLRNFFHYFHSKRGMWNRRTLRNT", "length": 1143 }, "evidence": [ { "id": "F1N0M7", "url": "https://omabrowser.org/oma/group/F1N0M7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6L8S8-1", "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase 3", "gene_name": "B4galnt3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSPRAALLMLLLRPIKLLRRRFRLLLLLAVVSVGLWTLYLELVASAQAGGNPLNHRYGSWRELAKALASRNIPAVDPNLQFYRPQRLSLKDQEIARSRSRNSSYLKWNKPVPWLSEFRGHANLHVFEDWCGSSIQQLRNNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSRDDQVSGLQLLASVGKTGKEWTAPGEFGKFQSQISKPVSLSASLRYYFEVLHKQNDEGTDHVEVAWRRNDPGAKFTIIDSPFLSLFTNETILRMDEVGHIPQTAASHVGSSNTPPRDEQPPADMLRPDPRDTLFRVPLIAKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQESAYDQDRSSFQEYIKMDKPEKHGPEQPAGLEDGLLEESQYEDVPEEIPTSQDQNTGIQGRKQKTISTPGLGVTDYHLRKLLARSQSGPVAPLSKQNSTTAFPTRTSNIPVQRPEKSPVPSRDLSHSDQGARRNLPLIQRARPTGDRPGKTLEQSQWLNQVESFIAEQRRGDRIEPPTPSRGWRPEEDVVIAADQEGEVEEEEEGEDEEEDMSEVFEYVPMFDPVVNWGQTFSAQNLDFQALRTDWIDLNCNTSGNLLLPEQEALEVTRVFLRKLSQRTRGRYQLQRIVNVEKRQDRLRGGRYFLELELLDGQRLVRLSEYVSTRGWRGGDHPGREDTEARNLQGLVWSPRNRHRHVLNAQDPEPKLCWPQGFSWNHRAVVHFIVPVKNQARWVQQFIRDMESLSQVTGDAHFSIIITDYSSEDMDVEMALKRSRLRSYQYLKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGIIDTIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDKIGGMNTKEFRDRWGGEDWELLDRILQAGLEVERLSLRNFFHHFHSKRGMWNRRQMKMP", "length": 986 }, "evidence": [ { "id": "F1N0M7", "url": "https://omabrowser.org/oma/group/F1N0M7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6L9W6-1", "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase 3", "gene_name": "B4GALNT3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGSWRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSNSSYLKWNKPVPWLSEFRGRANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSASHRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQTAASHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLPLQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGLEQPGFEENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLRSLRKLLAQPREGLLAPFSKRNSTASFPGRTSHIPVQQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKNLPQMRGPRPRPAGDSPRKTQWLNQVESYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQEGQVEGEEEGEEEEEEEDMSEVFEYVPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTSGNLLLPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQRVVRLSEYVSARGWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGFSWSHRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKRSKLRSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGKMAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDRILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMKTL", "length": 998 }, "evidence": [ { "id": "F1N0M7", "url": "https://omabrowser.org/oma/group/F1N0M7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "F1N0M7", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity", "id": "GO:0033842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033842", "evidence": [ { "database": "UniProtKB", "id": "F1N0M7", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ], "pmid": "" }, { "name": "acetylgalactosaminyltransferase activity", "id": "GO:0008376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008376", "evidence": [ { "database": "UniProtKB", "id": "F1N0M7", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20493", "name": "", "equation": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0M7-1", "G3X7L4-1" ], "evidence": [ { "id": "20493", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20493" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1N0M7", "gene_name": "B4GALNT3", "activity": [ { "ec_number": "2.4.1.244", "activity": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+).", "evidence": [ { "id": "F1N0M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ] }, { "ec_number": "2.4.1.244", "activity": "", "evidence": [ { "id": "F1N0M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" } ] } ] }, { "uniprot_ac": "G3X7L4", "gene_name": "B4GALNT4", "activity": [ { "ec_number": "2.4.1.244", "activity": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+).", "evidence": [ { "id": "G3X7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X7L4" } ] }, { "ec_number": "2.4.1.244", "activity": "", "evidence": [ { "id": "G3X7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X7L4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0M7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1003, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0M7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0M7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M7" }, { "id": "PS51820", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51820" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PA14", "eco_id": "ECO_0000259", "start_pos": 117, "end_pos": 278, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00017IP", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G00193HL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00230CO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00279YF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00318OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00372ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00470UO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00582VL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00624KQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00636QL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00645SW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00740UU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00743WU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00805TZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00915XC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00979HB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01158PQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01323LL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01414CL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01510MQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01522FD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02057LB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02310VX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02473HY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02670IJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G02872OI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02915XR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03165SD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03319HQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03834RX", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G03855LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03921DY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03944IG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04048YA", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G04062VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04077XA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04152JO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04348PK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04423MO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04506OA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04622LK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04699RP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04705FR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G04706FE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04743RS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04846SY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G04893EC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04895YD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05081RC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05151WT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05187WH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05309HX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05377HJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05395ZW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05428SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05611SB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05763EW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G05786ES", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G05947LR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06070KG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06100NA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G06216UH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G06578MY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06585BR", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G06635WE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06673TD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G06729UK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G07015TW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07098TP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07123BN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07292LK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07907HC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07982BU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08009LH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G08061ME", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08070PH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08185DV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08211PB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G08492JZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08627LE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G08820NR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08979EC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09150LP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09255AF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09343IK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09419PO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09482NW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09511OW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09513RD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G09605DV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09670SR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09826WW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09852PG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10056LU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10223RO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10224GU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10235QZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10258MC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10330XJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G10435LQ", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G10716SX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10835DD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11146NT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G11278YL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11542JY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11762BM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11846US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11907PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11960UF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12034WA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12061IK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12133DL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12243WN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12266SO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12524BD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12878NK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12906ZR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12951NT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13151XE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13363OF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13439WS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13454LA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13515ZY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13545DP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13667MS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13715AS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G13781GJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13785QH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13836YR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13849RQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13964RX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13968YX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14066AX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14068WV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14238UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14281OH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14358WN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14383IU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14510SZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14695KF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14942ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15192BD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15591FI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15688CE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15719NX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G15859AU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16042LM", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G16058FI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16122GW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16230QU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16316CS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16402DK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16433RL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16523AO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16578NV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16705KA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16733YD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16943PO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17107VB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17160IJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17172ZR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17274VA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17344FG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17724EN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17762ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17766PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17964DY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17964XN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17968CJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17996ZO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18125MC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18422UF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18583QC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18604DH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18640IS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18641OW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18676RO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18806VU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18871XZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18960KY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19019TY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19106CR", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G19271GD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19483RZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19517HH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G19868AX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19962XN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20170YB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20173ZW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G20214UH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G20532UQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G20830HU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20956ZK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21007OV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21118MX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21203TW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21256CQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21266OX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21456NQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21495CG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G21519PO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21586RO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21627CA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21695CC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21927IY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21969ZB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22021IQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22246QW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G22406UE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22432GF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22487WN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G22525ER", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22699CC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G22927MQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23408TM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G23416CI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23416VJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23484GM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23581SB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G23614TN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23626NI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23647WB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24338MH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G24366XJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24374US", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G24413UY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G24529GI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24596WC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G24812WY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24867FR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24870CO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G24875YE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G24954RW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25350TT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25423CA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25461TF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25473LQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G25495SR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25741AM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25781GZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25835MT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26021BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26134IV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26265RM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26315ZA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G26640MK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26814OZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26822XQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26881SV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G27121CS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27129QJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27169KC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27259XX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27262AE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27281KS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27669RW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27776PG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27983PC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28090UW", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G28298VW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28502IW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28629HE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G28663QF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G28878FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28882QV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28936HJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G28974LC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29026MS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29159AI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29377XJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29434RB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29574TI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29676WX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29870RM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G30129GW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30229OR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G30303UZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30372WK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G30471GP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30526TI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30542PN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30553TG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30553WH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30615JE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30626EL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G30723RE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30724LC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G30857WQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30928KF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31186LT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G31390DC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31515BE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31735XJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G31859DB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32283ZK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32375YW", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G32659RY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32699RJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32952DG", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G32981ZX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33122OO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G33287EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33405HJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33415VV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33460HH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33522ME", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G33576LI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G33612TW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33720LK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33721WT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33909XJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33912SR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34068FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34259YJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34293SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34330HT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G34383AG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G34394KR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G34612DX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G34631OW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G34815RA", "type": "N-linked", "subtype": "Alditol-reduced" }, { "glytoucan_ac": "G34838RM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34875RO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34905OT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35179MW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G35194OT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35245OK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35380EO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G35429JB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35438GZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35524PN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35675LO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35698OP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35808UX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36042WR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36171JA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36606ZN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36608LK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36712XC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36898CO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36977EW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36978FH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37106KN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37180VK", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G37200YF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37276TY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G37344VM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G37385TT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37476QB", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G37552GO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37565XR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G37649DI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37689LY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37817YS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37884CG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37919OJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G38113WG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G38115KZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G38141KL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G38217AM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38371WW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38373BD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38540KX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38567BT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38625SV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38817ZQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38867AF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39218IL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39298CN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G39323NG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G39379ZG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39437XQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39473HX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39540XG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39570CO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39794DN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39846LH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40000FH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40065EM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40096SL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G40138ED", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40309II", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G40786FB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41182NJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G41191PN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41343RT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41563EN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41708PN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42042EG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G42133YG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42205PU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42482KG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42525DE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G42605KJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42779AL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42841BX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G43000DM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G43091XE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43265RC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G43346PX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43507KQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43523KB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43749GH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43767FS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44089VB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44152CO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44770ZI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44799JP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44904UE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44946WH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44988YY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45048TZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G45061BH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45264AM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45441OP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45640DX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45656VV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45661AN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G45681QN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G45705HF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45719AB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45747TC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45849QU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G46062IG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46068IJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G46108US", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G46170RN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46195GB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G46224CH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46374MQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46511PG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46604MY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46675IY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G46764NJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46799MV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46945LQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47206MY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47206OM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G47216WH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47253EY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47407FC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G47497WE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G47562LV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47788QH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47822QX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47909VC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48103NH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48185FI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48698GX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48714ZW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48757CJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48774NH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48876AB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49024AU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49071WQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49129IG", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G49168NM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49353CV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49353WO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49382OI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49596EV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49664YG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49743VF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49747JY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G49872TN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49928PT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49963FN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50076JD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50458XA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50531NJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50573QG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50709EY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G50943ZX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51170KR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52144RR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52358FD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G52622YD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52676LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52776UT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53347XD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53386CI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53479GY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53605PF", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G53675DS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53808AO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53859QY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53933HU", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G53950KA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53985AY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54042WO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54076UX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54311AW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54323TO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54370BN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G54386YN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54411WK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54499PQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54552DT", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G54587HN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54764AV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54884LT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54956ME", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54974KE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G55041IW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55065WV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55250XM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55402UT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55953GF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G56175MM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56271TF", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G56364PT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G56408DR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56553LA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56721EV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56852BX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57084IU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57250WI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G57415BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57710XG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57741SS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G57787IU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57887UL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G58403SV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58576YF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58599KY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G58768FH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58807XI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58808TX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58932AD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58971UG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59029AQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G59065YH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59149SL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59231NT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G59361OW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59456VR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59741XZ", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G59752BW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G59783ST", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59877NF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59984BF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60255MW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60284TU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60359JC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60532CM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60631GY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G60653VD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60837AI", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G60963AS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61049GY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61431VC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G61718TK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61800QD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62034LF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62608YY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62848AR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62866HT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62883YA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62955ZH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G62997JW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63065KG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G63074CQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63136MB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G63185SB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G63240YA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63585HN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63714PL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63770IR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64186MJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G64379QQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64550WP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64660QV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64803AP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64823DM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65030KC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G65117HG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65239SF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65282FW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65302CF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65464PI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65645WO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65697SK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65796FM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G65937DK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65981EG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66254YL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66261HZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66281YY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G66474IG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66655HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66828DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66866LE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G66924VF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G67045LB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G67385FR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G67534LV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G67549HD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G67887EF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G68045UG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68059HB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68060HU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68259WQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68560PY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G68603JE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68651MF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68679LW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68758PE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68873AT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68955EJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G69044AJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69113LL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69118IP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69121YI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69532KY", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G69627PQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G69704YD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G69749VJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G69905CP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69985ZX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G70187MS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70236BB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G70332AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70355HG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G70374KJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70439DD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G70497TX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G70859XP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70881GL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71156OO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71296WI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71320DE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71332MU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71496TN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71550UL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71673XZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71695GS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71815IQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71857KQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72018SI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72082VM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72221XM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72231RH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G72260GO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72406BE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72460OS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72687PY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G73119DN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73271AZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73418FX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73518FM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G73609FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73717KI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G73763NQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73839CW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73946HM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G74364UH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G74438AB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74503BE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74639KZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74683SL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74716XL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74782AW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74807KC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75107JX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75318VB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75333EX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75359HS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G75465ST", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75671DO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75734VP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75794LV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75853FN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76136FD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76225JQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76436VC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76505NV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77104ED", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77174TF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77198CF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G77384FE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77396HT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77639OD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77643ZX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G77889NO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78097CL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78295SU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78342SP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78509TX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78580RN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78627AJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78742VP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G78813BX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78890OB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78944YP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79210AT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79344MI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79369FE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79538ZU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79561SK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G79643VQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79803HS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79985AQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79996DQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G80019MD", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G80202YF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80295DJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G80487YW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G80514ZZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G80570FW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G80804PR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80962OX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81153QC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81332EX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G81358TE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81599LG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81699VA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81796XK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81819VG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G81914RV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81915YU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81923ER", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82110HP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82312JY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82420AC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82458BB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G82503FV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82577CR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G82639GQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G82805YZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82841UV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G83062JW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G83644CC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83875GK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G83945MQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84068IS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G84135ZM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G84165BQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84167AV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G84287MH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G84329MX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G84331AQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G84362IY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84495HF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84504LI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84517LG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G84692YW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84791TM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85180ML", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85401TI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85417QF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85458AY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85471HV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85542KD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85856NQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85891FA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G86102AA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G86504RY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86566MF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G86606NT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86912SJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87030DQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87206PT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87217OF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87485GH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87656FV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87773EB", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G88315CV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G88417ED", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88461FF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88814KX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88948CY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88972LX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88992QY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89096IL", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G89264TR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G89285QP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89398CR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G89498BT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89911NQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89941FZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90052RE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90065BD", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G90081OR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90175OT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90182FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90192ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90238QO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G90712YJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G90745FS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90754EO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90764JW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90873EK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91114LN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91337ZP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G91658LT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91817JL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G91883RB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92021FW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92101NE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92219PK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92337QR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92413DG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92597HN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92712BL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G92738VX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G92779QW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92814GV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92918FJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93132NV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93198UO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G93215WE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G93310KW", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G93438EY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G93446UA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G93470MW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G93746CY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93839ET", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93857UP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G93906VI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93994MR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G94096QV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G94166QX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G94296FS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G94366XH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G94423NC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G94490EL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G94776IJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94926TV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G94946LG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95473VJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95658PH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95710IM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G95788IL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G95940WS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G95997CK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96063MG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G96079QX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96081GH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G96644ZT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96931TH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96932XT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97088QZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97549FZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G97764XA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97790WL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G97832IV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97948YW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G98066UT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98078SH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G98117HW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G98121YG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98549NZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98608RK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98698LY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98716RB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G98855LF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99009ZZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99225RS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99390JL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99501KJ", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G99714FV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99897FQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99935CU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G99954GW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99969SS", "type": "N-linked", "subtype": "Hybrid" } ], "enzyme_annotation": [ { "ec_number": "2.4.1.244", "ec_name": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+).", "evidence": [ { "id": "2.4.1.244", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.244" }, { "id": "2.4.1.244", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.244" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 285, "end_pos": 287 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 663, "end_pos": 665 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N153-1", "uniprot_ac": "F1N153", "uniprot_id": "F1N153_BOVIN", "mass": { "chemical_mass": 186281.0, "monoisotopic_mass": 186281.0 }, "refseq": { "ac": "XP_010819654", "name": "THO complex subunit 2 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819654" }, "gene_names": [ { "name": "THOC2", "type": "recommended", "evidence": [ { "id": "F1N153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ] }, { "name": "THOC2", "type": "synonym", "evidence": [ { "id": "XP_010819654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819654" } ] } ], "protein_names": [ { "name": "THO complex subunit 2", "type": "recommended", "evidence": [ { "id": "F1N153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N153/entry#names_and_taxonomy" } ] }, { "name": "THO complex subunit 2 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_010819654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819654" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THOC2", "url": "https://www.uniprot.org/uniprotkb/F1N153", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000008388", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008388", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507738", "url": "https://www.ncbi.nlm.nih.gov/gene/507738", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N153", "url": "https://www.orthodb.org/?gene=F1N153", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21597", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21597", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21597:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21597:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11262", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11262", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010819654", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819654", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N153-1", "url": "https://www.uniprot.org/uniprotkb/F1N153-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAATVVVPVEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGNITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIVEAKQIVRKLTMVVLSSDKIDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQSIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVSALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKEKMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKIQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSVSKSDESSTEDTDKSRERSQCGVKAVNKASSATPKGNSSNGNSGSNSSKTVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNVESKSTQEKEREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDITEPEREQKRRKIDTHPSPSHSSTVKMVYFQVTAILPKVPLGSENYASSPVISIHFLQDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGGDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR", "length": 1625, "header": "tr|F1N153-1|F1N153_BOVIN Isoform 1 of THO complex subunit 2 OS=Bos taurus OX=9913 GN=THOC2 PE=3 SV=4 CANONICAL=F1N153-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A7/entry", "sequence": { "sequence": "MAAATVVVPVEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGNITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIVEAKQIVRKLTMVVLSSDKIDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQSIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVSALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKEKMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKIQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSVSKSDESSTEDTDKSRERSQCGVKAVNKASSATPKGNSSNGNSGSNSSKTVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNVESKSTQEKEREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDITEPEREQKRRKIDTHPSPSHSSTVKVTAILPKVPLGSENYASSPVISIHFLQDSLIELKESSAKITQKTKRYI", "length": 1473, "header": "tr|A0AAA9S7A7-1|F1N153_BOVIN Computationally mapped isoform of THO complex subunit 2 OS=Bos taurus OX=9913 GN=THOC2 PE=3 SV=1 CANONICAL=F1N153-1" }, "locus": { "chromosome": "X", "start_pos": 8083076, "end_pos": 7980985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102375.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102375.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079195.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079195.1" } ] } }, { "isoform_ac": "A0AAA9SJ75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ75/entry", "sequence": { "sequence": "MAAATVVVPVEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGNITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIVEAKQIVRKLTMVVLSSDKIDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQSIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVSALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKEKMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKIQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSVSKSDESSTEDTDKSRERSQCGVKAVNKASSATPKGNSSNGNSGSNSSKTVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNVESKSTQEKEREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDITEPEREQKRRKIDTHPSPSHSSTVKVTAILPKVPLGSENYASSPVISIHFLQDSLIELKESSAKV", "length": 1465, "header": "tr|A0AAA9SJ75-1|F1N153_BOVIN Computationally mapped isoform of THO complex subunit 2 OS=Bos taurus OX=9913 GN=THOC2 PE=3 SV=1 CANONICAL=F1N153-1" }, "locus": { "chromosome": "X", "start_pos": 8083076, "end_pos": 7981377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088245.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088245.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086313.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086313.1" } ] } }, { "isoform_ac": "F1N153-1", "url": "https://www.uniprot.org/uniprotkb/F1N153/entry", "sequence": { "sequence": "MAAATVVVPVEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGNITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIVEAKQIVRKLTMVVLSSDKIDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQSIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVSALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKEKMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKIQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSVSKSDESSTEDTDKSRERSQCGVKAVNKASSATPKGNSSNGNSGSNSSKTVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNVESKSTQEKEREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDITEPEREQKRRKIDTHPSPSHSSTVKMVYFQVTAILPKVPLGSENYASSPVISIHFLQDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGGDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR", "length": 1625, "header": "tr|F1N153-1|F1N153_BOVIN Isoform 1 of THO complex subunit 2 OS=Bos taurus OX=9913 GN=THOC2 PE=3 SV=4 CANONICAL=F1N153-1" }, "locus": { "chromosome": "X", "start_pos": 8083076, "end_pos": 7973387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011040.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011040.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011040.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011040.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "THO complex", "id": "GO:0000347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000347", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" }, { "name": "THO complex part of transcription export complex", "id": "GO:0000445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000445", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" }, { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" }, { "name": "poly(A)+ mRNA export from nucleus", "id": "GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1N153", "url": "https://www.uniprot.org/uniprotkb/F1N153" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1010, "end_pos": 1012, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1252, "end_pos": 1254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1261, "end_pos": 1263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1473, "end_pos": 1475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1536, "end_pos": 1538, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1563, "end_pos": 1565, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 787, "end_pos": 789, "annotation": "n_glycosylation_sequon" }, { "start_pos": 971, "end_pos": 973, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N153" }, { "id": "PF16134", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16134" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THO complex subunit 2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 418, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N153" }, { "id": "PF11262", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THO complex subunitTHOC2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 873, "end_pos": 1173, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N153" }, { "id": "PF11732", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11732" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THO complex subunitTHOC2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 568, "end_pos": 643, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1010, "end_pos": 1012 }, { "start_pos": 1252, "end_pos": 1254 }, { "start_pos": 1261, "end_pos": 1263 }, { "start_pos": 1473, "end_pos": 1475 }, { "start_pos": 1536, "end_pos": 1538 }, { "start_pos": 1563, "end_pos": 1565 }, { "start_pos": 186, "end_pos": 188 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 529, "end_pos": 531 }, { "start_pos": 787, "end_pos": 789 }, { "start_pos": 971, "end_pos": 973 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0V7-1", "uniprot_ac": "F1N0V7", "uniprot_id": "F1N0V7_BOVIN", "mass": { "chemical_mass": 75595.0, "monoisotopic_mass": 75595.0 }, "refseq": { "ac": "NP_001095400", "name": "RNA polymerase II-associated protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095400" }, "gene_names": [ { "name": "RPAP3", "type": "recommended", "evidence": [ { "id": "F1N0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0V7" } ] }, { "name": "RPAP3", "type": "synonym", "evidence": [ { "id": "NP_001095400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095400" } ] } ], "protein_names": [ { "name": "RNA polymerase II-associated protein 3", "type": "recommended", "evidence": [ { "id": "F1N0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0V7/entry#names_and_taxonomy" } ] }, { "name": "RNA polymerase II-associated protein 3", "type": "synonym", "evidence": [ { "id": "NP_001095400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095400" } ] } ], "function": [ { "annotation": "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.", "evidence": [ { "database": "UniProtKB", "id": "F1MFU5", "url": "https://www.uniprot.org/uniprotkb/F1MFU5#function" }, { "database": "UniProtKB", "id": "ARBA00056798", "url": "https://www.uniprot.org/uniprotkb/ARBA00056798#function" }, { "database": "UniProtKB", "id": "A0AAA9SL80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL80#function" }, { "database": "UniProtKB", "id": "F1N0V7", "url": "https://www.uniprot.org/uniprotkb/F1N0V7#function" }, { "database": "UniProtKB", "id": "A0AAA9STZ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0V7", "url": "https://www.uniprot.org/uniprotkb/F1N0V7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPAP3", "url": "https://www.uniprot.org/uniprotkb/F1N0V7", "locus": { "chromosome": "5", "start_pos": 32648548, "end_pos": 32589529, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018690", "url": "https://www.ensembl.org/id/ENSBTAG00000018690" } ] } } ], "crossref": [ { "id": "F1N0V7", "url": "https://alphafold.ebi.ac.uk/entry/F1N0V7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018690", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018690", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510621", "url": "https://www.ncbi.nlm.nih.gov/gene/510621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510621", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510621", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MFU5", "url": "https://www.orthodb.org/?gene=F1MFU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0V7", "url": "https://www.orthodb.org/?gene=F1N0V7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46423:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46423:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13877", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13877", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095400", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SL80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFU5", "url": "https://www.uniprot.org/uniprotkb/F1MFU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFU5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0V7", "url": "https://www.uniprot.org/uniprotkb/F1N0V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0V7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0V7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTSKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKVKESSKKTKDENAKNRIKSYDYEAWAKLDVDSILDELDKEESTHDSVSQESESEEDGIHVDSQKALALKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALNRSYTKAYARRGAARFALQKLEDAKKDYEKVLELEPNNFEATNELRKINQALTSKEDSYPGETDTMVKSDEGEKKQIEEQQNKQQAVSEKDRGNAFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAVLLDGSYSKAFARRGTARTFLGKLSEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVIKPIDNLPHLGSTKPLKKVIIEETGNLIQTVDVRDSTATVAAAECNPVTLASVTATTGMTNKNTSQDDLLPTSDVPKAKVLKIEEISDTSALHSHVNLKKDVCQSLSEKIPTEVDKAPAQFIRTVLPPVPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEKEKPSLIFEILQRLSELRRFDMAVMFMSESEKKITRVLFNHIDKSGLNDNSVEELKKRYGG", "length": 665, "header": "tr|F1N0V7-1|F1N0V7_BOVIN Isoform 1 of RNA polymerase II-associated protein 3 OS=Bos taurus OX=9913 GN=RPAP3 PE=3 SV=2 CANONICAL=F1N0V7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL80/entry", "sequence": { "sequence": "MNVIPSGAGSFWLPAWTQVPWERKDDGDWSVKTLHAVMASTSKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKVKESSKKTKDENAKNRIKSYDYEAWAKLDVDSILDELDKEESTHDSVSQESESEEDGIHVDSQKALALKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALNRSYTKAYARRGAARFALQKLEDAKKDYEKVLELEPNNFEATNELRKINQALTSKEDSYPGETDTMVKSDEGEKKQIEEQQNKQQAVSEKDRGNAFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAVLLDGSYSKAFARRGTARTFLGKLSEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVIKPIDNLPHLGSTKPLKKVIIEETGNLIQTVDVRDSTATVAAAECNPVTLASVTATTGMTNKNTSQDDLLPTSDVPKAKVLKIEEISDTSALHSHVNLKKDVCQSLSEKIPTEVDKAPAQFIRTVLPPVPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEKEKPSLIFEILQRLSELRRFDMAVMFMSESEKKITRVLFNHIDKSGLNDNSVEELKKRYGG", "length": 702, "header": "tr|A0AAA9SL80-1|F1N0V7_BOVIN Computationally mapped isoform of RNA polymerase II-associated protein 3 OS=Bos taurus OX=9913 GN=RPAP3 PE=3 SV=1 CANONICAL=F1N0V7-1" }, "locus": { "chromosome": "5", "start_pos": 32627524, "end_pos": 32590060, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093178.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093178.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083400.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083400.1" } ] } }, { "isoform_ac": "A0AAA9STZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ0/entry", "sequence": { "sequence": "MASTSKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKVKESSKKTKDENAKNRIKSYDYEAWAKLDVDSILDELDKEESTHDSVSQESESEEDGIHVDSQKALALKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALNRSYTKAYARRGAARFALQKLEDAKKDYEKVLELEPNNFEATNELRKINQALTSKEDSYPGETDTMVKSDEGEKKQIEEQQNKQQAVSEKDRGNAFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAVLLDGSYSKAFARRGTARTFLGKLSEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVIKPIDNLPHLGSTKPLKKVIIEETGNLIQTVDVRDSTATVAAAECNPVTLASVTATTGMTNKNTSQDDLLPTSDVPKAKVLKIEEISDTSALHSHVNLKKDVCQSLSEKIPTEVDKAPAQFIRTVLPPVPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEKEKPSLIFEILQRLSELRRFDMAVMFMSESEKKNRRGSGM", "length": 644, "header": "tr|A0AAA9STZ0-1|F1N0V7_BOVIN Computationally mapped isoform of RNA polymerase II-associated protein 3 OS=Bos taurus OX=9913 GN=RPAP3 PE=3 SV=1 CANONICAL=F1N0V7-1" }, "locus": { "chromosome": "5", "start_pos": 32648497, "end_pos": 32593984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088523.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088523.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087468.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087468.1" } ] } }, { "isoform_ac": "F1MFU5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFU5/entry", "sequence": { "sequence": "MASTSKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKVKESSKKTKDENAKNRIKSYDYEAWAKLDVDSILDELDKEESTHDSVSQESESEEDGIHVDSQKALALKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALNRSYTKAYARRGAARFALQKLEDAKKDYEKVLELEPNNFEATNELRKINQALTSKEDSYPGETDTMVKSDEGEKKQIEEQQNKQQAVSEKDRGNAFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAVLLDGSYSKAFARRGTARTFLGKLSEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQTVDVRDSTATVAAAECNPVTLASVTATTGMTNKNTSQDDLLPTSDVPKAKVLKIEEISDTSALHSHVNLKKDVCQSLSEKIPTEVDKAPAQFIRTVLPPVPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEKEKPSLIFEILQRLSELRRFDMAVMFMSESEKKITRVLFNHIDKSGLNDNSVEELKKRYGG", "length": 631, "header": "tr|F1MFU5-1|F1MFU5_BOVIN Computationally mapped isoform of RNA polymerase II-associated protein 3 OS=Bos taurus OX=9913 GN=RPAP3 PE=3 SV=4 CANONICAL=F1N0V7-1" }, "locus": { "chromosome": "5", "start_pos": 32627524, "end_pos": 32593984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054570.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054570.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048352.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048352.4" } ] } }, { "isoform_ac": "F1N0V7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0V7/entry", "sequence": { "sequence": "MASTSKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKVKESSKKTKDENAKNRIKSYDYEAWAKLDVDSILDELDKEESTHDSVSQESESEEDGIHVDSQKALALKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALNRSYTKAYARRGAARFALQKLEDAKKDYEKVLELEPNNFEATNELRKINQALTSKEDSYPGETDTMVKSDEGEKKQIEEQQNKQQAVSEKDRGNAFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAVLLDGSYSKAFARRGTARTFLGKLSEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVIKPIDNLPHLGSTKPLKKVIIEETGNLIQTVDVRDSTATVAAAECNPVTLASVTATTGMTNKNTSQDDLLPTSDVPKAKVLKIEEISDTSALHSHVNLKKDVCQSLSEKIPTEVDKAPAQFIRTVLPPVPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEKEKPSLIFEILQRLSELRRFDMAVMFMSESEKKITRVLFNHIDKSGLNDNSVEELKKRYGG", "length": 665, "header": "tr|F1N0V7-1|F1N0V7_BOVIN Isoform 1 of RNA polymerase II-associated protein 3 OS=Bos taurus OX=9913 GN=RPAP3 PE=3 SV=2 CANONICAL=F1N0V7-1" }, "locus": { "chromosome": "5", "start_pos": 32627524, "end_pos": 32593984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024878.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024878.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024878.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024878.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510621", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510621", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "R2TP complex", "id": "GO:0097255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097255", "evidence": [ { "database": "UniProtKB", "id": "F1N0V7", "url": "https://www.uniprot.org/uniprotkb/F1N0V7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0V7", "url": "https://www.uniprot.org/uniprotkb/F1N0V7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0V7" }, { "id": "PF13877", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13877" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RNA-polymerase II-associated protein 3-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 546, "end_pos": 636, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 479, "end_pos": 481 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBA0-1", "uniprot_ac": "E1BBA0", "uniprot_id": "E1BBA0_BOVIN", "mass": { "chemical_mass": 170668.0, "monoisotopic_mass": 170668.0 }, "refseq": { "ac": "XP_024850994", "name": "arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850994" }, "gene_names": [ { "name": "ARAP3", "type": "recommended", "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ] }, { "name": "FCHSD1", "type": "recommended", "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ] }, { "name": "ARAP3", "type": "synonym", "evidence": [ { "id": "XP_024850994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850994" }, { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ] } ], "protein_names": [ { "name": "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0/entry#names_and_taxonomy" } ] }, { "name": "Centaurin-delta-3", "type": "synonym", "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0/entry#names_and_taxonomy" } ] }, { "name": "arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024850994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850994" } ] } ], "function": [ { "annotation": "Promotes actin polymerization mediated by SNX9 and WASL.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1W0#function" }, { "database": "UniProtKB", "id": "ARBA00058334", "url": "https://www.uniprot.org/uniprotkb/ARBA00058334#function" }, { "database": "UniProtKB", "id": "F1N6Q6", "url": "https://www.uniprot.org/uniprotkb/F1N6Q6#function" }, { "database": "UniProtKB", "id": "A0ABI0NV50", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV50#function" }, { "database": "UniProtKB", "id": "A0AAA9TYE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYE0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARAP3", "url": "https://www.uniprot.org/uniprotkb/E1BBA0", "locus": { "chromosome": "7", "start_pos": 52747027, "end_pos": 52771933, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015938", "url": "https://www.ensembl.org/id/ENSBTAG00000015938" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000049248", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049248", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04385", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04385", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11895", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11895", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13253", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13253", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13254", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13254", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17902", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17902", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112447442", "url": "https://www.ncbi.nlm.nih.gov/gene/112447442", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "529296", "url": "https://www.ncbi.nlm.nih.gov/gene/529296", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112447442", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112447442", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N6Q6", "url": "https://www.orthodb.org/?gene=F1N6Q6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15735", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15735", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15735:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15735:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45899", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45899", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45899:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45899:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00611", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00611", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024850994", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJ14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJ14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKD1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1W0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1W0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NV50", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NV50-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBA0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q6", "url": "https://www.uniprot.org/uniprotkb/F1N6Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q6-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPQDLDIAVWLALVHLEQYADAFRQQGLATAGAARGLGHGELRQLGVNATGHRKRILRLLQAGTAEGPPDPQPESAMEPSHSPAPPAQPTKPVPKPRTVFGGLSGSATTQRPGLGPAVWRPEASKSPEPSLSPRSPTVPPRSSSEQPSASNTVEMMPNAIYFGLDLRGGAQTAQDMAPDSSQTAAPTPALRPTTGTVHIMDPGCLYYGVQPVGVPGAPDRREGRGVCQERAEHRLSRPDLEAREDAGYASLELPGDSTLSLPTLDTETNDDLISPYASFSSTADRPTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRHCADCGASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGSLPPGEGLHPDTTPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVAGPNLLKNMTQLLCVEAFEGEEPWTPSALDGSFPSLLPPDPSPGVYNEVVVPATYSSFLYCGPISNKAGPPPPRRGRDAPPRLWCVLGAALEMFVSESSPEPLHLIQPQDVVCLGVNPPPTDPGDLDRFPFSFELILTGGRIQHFGTDGADSLEAWTSALGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTTLAPGLWMSGFGLLRGDHLFLCPASGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQAEGRLDFSAWNTAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLKLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKEVIGCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDPDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVFIEQQLPDNCVTLKVSPTLTAEELTNQVLEIRGTAAGTDLWVTFEIREHGELERPLHPKERVLEQALQWCQLPEPCSASLLLRKVSLAHAGCLFTGIRRESPRVGLLRCREEPPRLLGNRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEDAKVYLGIRKKFKPPTPWGFTLMLEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELTEDISTSFSTPRERTAKPETALPSQRSFDQYLLSKAGPQAWEERPPEPPPGPPSKSSPQTHGSLEEQLLQELSSLILRKGETTTDLGSPSQPSSPQPPSPNGLPTQTPGFPTQTPCTSSLPRSQPLT", "length": 1548, "header": "tr|E1BBA0-1|E1BBA0_BOVIN Isoform 1 of Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=4 CANONICAL=E1BBA0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJ14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ14/entry", "sequence": { "sequence": "MAAPQDLDIAVWLALVHLEQYADAFRQQGLATAGAARGLGHGELRQLGVNATGHRKRILRLLQAGTAEGPPDPQPESAMEPSHSPAPPAQPTKPVPKPRTVFGGLSGSATTQRPGLGPAVWRPEASKSPEPSLSPRSPTVPPRSSSEQPSASNTVEMMPNAIYFGLDLRGGAQTAQDMAPDSSQTAAPTPALRPTTGTVHIMDPGCLYYGVQPVGVPGAPDRREGRGVCQERAEHRLSRPDLEAREDAGYASLELPGDSTLSLPTLDTETNDDLISPYASFSSTADRPTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRHCADCGASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGSLPPGEGLHPDTTPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVAGPNLLKNMTQLLCVEAFEGEEPWTPSALDGSFPSLLPPDPSPGVYNEVVVPATYSSFLYCGPISNKAGPPPPRRGRDAPPRLWCVLGAALEMFVSESSPEPLHLIQPQDVVCLGVNPPPTDPGDLDRFPFSFELILTGGRIQHFGTDGADSLEAWTSALGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTTLAPGLWMSGFGLLRGDHLFLCPASGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQAEGRLDFSAWNTAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLKLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKEVIGCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDPDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVFIEQQLPDNCVTLKVSPTLTAEELTNQVLEIRGTAAGTDLWVTFEIREHGELERPLHPKERVLEQALQWCQLPEPCSASLLLRKVSLAHAGCLFTGIRRESPRVGLLRCREEPPRLLGNRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEDAKVYLGIRKKFKPPTPWGFTLMLEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELTEDISTSFSTPRERTAKPETALPSQRSFDQYLLSKAGPQAWEERPPEPPPGPPSKSSPQTHGSLEEQLLQELSSLILRKGETTTDLGSPSQPSSPQPPSPNGLPTQTPGFPTQTPCTSSLPRSQPLT", "length": 1535, "header": "tr|A0A3Q1LJ14-1|E1BBA0_BOVIN Computationally mapped isoform of Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=2 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52771916, "end_pos": 52748031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084139.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084139.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059252.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059252.2" } ] } }, { "isoform_ac": "A0A3Q1LKD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD1/entry", "sequence": { "sequence": "MEPSHSPAPPAQPTKPVPKPRTVFGGLSGSATTQRPGLGPAVWRPEASKSPEPSLSPRSPTVPPRSSSEQPSASNTVEMMPNAIYFGLDLRGGAQTAQDMAPDSSQTAAPTPALRPTTGTVHIMDPGCLYYGVQPVGVPGAPDRREGRGVCQERAEHRLSRPDLEAREDAGYASLELPGDSTLSLPTLDTETNDDLISPYASFSSTADRPTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRHCADCGASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGSLPPGEGLHPDTTPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVAGPNLLKNMTQLLCVEAFEGEEPWTPSALDGSFPSLLPPDPSPGVYNEVVVPATYSSFLYCGPISNKAGPPPPRRGRDAPPRLWCVLGAALEMFVSESSPEPLHLIQPQDVVCLGVNPPPTDPGDLDRFPFSFELILTGGRIQHFGTDGADSLEAWTSALGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTTLAPGLWMSGFGLLRGDHLFLCPASGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQAEGRLDFSAWNTAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLKLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKEVIGCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDPDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVFIEQQLPDNCVTLKVSPTLTAEELTNQVLEIRGTAAGTDLWVTFEIREHGELERPLHPKERVLEQALQWCQLPEPCSASLLLRKVSLAHAGCLFTGIRRESPRVGLLRCREEPPRLLGNRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEDAKVYLGIRKKFKPPTPWGFTLMLEKMHLYLSCTDEDEMWDWTTSILKAQRRLHNRRTLSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELTEDISTSFSTPRERTAKPETALPSQRSFDQYLLSKAGPQAWEERPPEPPPGPPSKSSPQTHGSLEEQLLQELSSLILRKGETTTDLGSPSQPSSPQPPSPNGLPTQTPGFPTQTPCTSSLPRSQPLT", "length": 1424, "header": "tr|A0A3Q1LKD1-1|E1BBA0_BOVIN Computationally mapped isoform of Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=1 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52771682, "end_pos": 52748031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086753.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086753.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056980.1" } ] } }, { "isoform_ac": "A0AAA9S1W0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1W0/entry", "sequence": { "sequence": "MQPPPRKVKPAQEVKLRFLEQLSILQTRQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRMVFGAWRCLLDATVAGGQARLQASDRYRDLAGGTGRSAKEQVLRKGAENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGLFHTRTSLQKLSTKLSAQSAQYSQQLRAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELLEHLRDPLTSLSRTELEAAEMALEHARHGRQATSQVSWEQDLELFLQEPGVFSPTPPQQFQPAGNDQVCVLELEGGAGGVAGQSGLEKEVQRWTSRAARDYKIQHHGHRVLQRLEQRRQQVPEREAPGIEQRLQEVRENIRRAQVSQVKGAARLALLQGAGLDVQHWLKPAMTQAQDEVEQERRLSEARLSQRDFSPTAEDVELSDFEECEETGELFEEPAPAALATRPLPCPAHVVFGYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFADLSFPESSRDSDNPLGAEPTAFLARALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGHVGVFPSLLVEELLGPPGPSELSDPEQMLPSPSPPSFSPPAPTSAVDGSPAPVLPGDPDLDCPGSLDMMAPRLRPMRPPPPPPAKAPDPGHPDPLT", "length": 690, "header": "tr|A0AAA9S1W0-1|E1BBA0_BOVIN Computationally mapped isoform of Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=1 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52744832, "end_pos": 52734837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079870.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079870.1" } ] } }, { "isoform_ac": "A0AAA9TYE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYE0/entry", "sequence": { "sequence": "MQPPPRKVKPAQEVKLRFLEQLSILQTRQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRMVFGAWRCLLDATVAGGQARLQASDRYRDLAGGTGRSAKEQVLRKGAENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGLFHTRTSLQKLSTKLSAQSAQYSQQLRAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELLEHLRDPLTSLSRTELEAAEMALEHARHGRQATSQVSWEQDLELFLQEPGVFSPTPPQQFQPAGNDQVCVLELEGGAGGVAGQSGLEKEVQRWTSRAARDYKIQHHGHRERRLSEARLSQRDFSPTAEDVELSDFEECEETGELFEEPAPAALATRPLPCPAHVVFGYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFADLSFPESSRDSDNPLGAEPTAFLARALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGHVGVFPSLLVEELLGPPGPSELSDPEQMLPSPSPPSFSPPAPTSAVDGSPAPVLPGDPDLDCPGSLDMMAPRLRPMRPPPPPPAKAPDPGHPDPLT", "length": 618, "header": "tr|A0AAA9TYE0-1|E1BBA0_BOVIN Computationally mapped isoform of Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=1 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52744832, "end_pos": 52734837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130410.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130410.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103369.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103369.1" } ] } }, { "isoform_ac": "A0ABI0NV50-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV50/entry", "sequence": { "sequence": "MWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLVKPAQEVKLRFLEQLSILQTRQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRMVFGAWRCLLDATVAGGQARLQASDRYRDLAGGTGRSAKEQVLRKGAENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGLFHTRTSLQKLSTKLSAQSAQYSQQLRAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELLEHLRDPLTSLSRTELEAAEMALEHARHGRQATSQVSWEQDLELFLQEPGVFSPTPPQQFQPAGNDQVCVLELEGGAGGVAGQSGLEKEVQRWTSRAARDYKIQHHGHRVLQRLEQRRQQVPEREAPGIEQRLQEVRENIRRAQVSQVKGAARLALLQGAGLDVQHWLKPAMTQAQDEVEQERRLSEARLSQRDFSPTAEDVELSDFEECEETGELFEEPAPAALATRPLPCPAHVVFGYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFADLSFPESSRDSDNPLGAEPTAFLARALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGHVGVFPSLLVEELLGPPGPSELSDPEQMLPSPSPPSFSPPAPTSAVDGSPAPVLPGDPDLDCPGSLDMMAPRLRPMRPPPPPPAKAPDPGHPDPLT", "length": 741, "header": "tr|A0ABI0NV50-1|A0ABI0NV50_BOVIN Computationally mapped isoform of F-BAR and double SH3 domains protein 1 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=1 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52749505, "end_pos": 52734837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137232.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137232.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104457.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104457.1" } ] } }, { "isoform_ac": "E1BBA0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBA0/entry", "sequence": { "sequence": "MAAPQDLDIAVWLALVHLEQYADAFRQQGLATAGAARGLGHGELRQLGVNATGHRKRILRLLQAGTAEGPPDPQPESAMEPSHSPAPPAQPTKPVPKPRTVFGGLSGSATTQRPGLGPAVWRPEASKSPEPSLSPRSPTVPPRSSSEQPSASNTVEMMPNAIYFGLDLRGGAQTAQDMAPDSSQTAAPTPALRPTTGTVHIMDPGCLYYGVQPVGVPGAPDRREGRGVCQERAEHRLSRPDLEAREDAGYASLELPGDSTLSLPTLDTETNDDLISPYASFSSTADRPTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRHCADCGASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGSLPPGEGLHPDTTPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVAGPNLLKNMTQLLCVEAFEGEEPWTPSALDGSFPSLLPPDPSPGVYNEVVVPATYSSFLYCGPISNKAGPPPPRRGRDAPPRLWCVLGAALEMFVSESSPEPLHLIQPQDVVCLGVNPPPTDPGDLDRFPFSFELILTGGRIQHFGTDGADSLEAWTSALGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTTLAPGLWMSGFGLLRGDHLFLCPASGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQAEGRLDFSAWNTAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLKLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKEVIGCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDPDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVFIEQQLPDNCVTLKVSPTLTAEELTNQVLEIRGTAAGTDLWVTFEIREHGELERPLHPKERVLEQALQWCQLPEPCSASLLLRKVSLAHAGCLFTGIRRESPRVGLLRCREEPPRLLGNRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEDAKVYLGIRKKFKPPTPWGFTLMLEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELTEDISTSFSTPRERTAKPETALPSQRSFDQYLLSKAGPQAWEERPPEPPPGPPSKSSPQTHGSLEEQLLQELSSLILRKGETTTDLGSPSQPSSPQPPSPNGLPTQTPGFPTQTPCTSSLPRSQPLT", "length": 1548, "header": "tr|E1BBA0-1|E1BBA0_BOVIN Isoform 1 of Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Bos taurus OX=9913 GN=ARAP3 PE=4 SV=4 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52771916, "end_pos": 52748031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021198.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021198.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021198.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021198.7" } ] } }, { "isoform_ac": "F1N6Q6-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q6/entry", "sequence": { "sequence": "MWAGLPRVPESSRCLGRSGDAAAAPKSEAGPGGEASLPGAAEHPSDPAAERGRPTGGYQALQKLAGPFLKREGHRSGEMDSRMVFGAWRCLLDATVAGGQARLQASDRYRDLAGGTGRSAKEQVLRKGAENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGLFHTRTSLQKLSTKLSAQSAQYSQQLRAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELLEHLRDPLTSLSRTELEAAEMALEHARHGRQATSQVSWEQDLELFLQEPGVFSPTPPQQFQPAGNDQVCVLELEGGAGGVAGQSGLEKEVQRWTSRAARDYKIQHHGHRVLQRLEQRRQQVPEREAPGIEQRLQEVRENIRRAQVSQVKGAARLALLQGAGLDVQHWLKPAMTQAQDEVEQERRLSEARLSQRDFSPTAEDVELSDFEECEETGELFEEPAPAALATRPLPCPAHVVFGYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFADLSFPESSRDSDNPLGAEPTAFLARALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGHVGVFPSLLVEELLGPPGPSELSDPEQMLPSPSPPSFSPPAPTSAVDGSPAPVLPGDPDLDCPGSLDMMAPRLRPMRPPPPPPAKAPDPGHPDPLT", "length": 694, "header": "tr|F1N6Q6-1|F1N6Q6_BOVIN Computationally mapped isoform of F-BAR and double SH3 domains protein 1 OS=Bos taurus OX=9913 GN=FCHSD1 PE=4 SV=4 CANONICAL=E1BBA0-1" }, "locus": { "chromosome": "7", "start_pos": 52744890, "end_pos": 52734837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021194.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021194.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021194.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021194.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 189, "start_aa": "Thr", "end_pos": 189, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr189", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 747, "start_aa": "Thr", "end_pos": 747, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr747", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:112447442", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112447442", "resource": "KEGG Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate binding", "id": "GO:0005547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005547", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4-bisphosphate binding", "id": "GO:0043325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043325", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "positive regulation of supramolecular fiber organization", "id": "GO:1902905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902905", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "positive regulation of cytoskeleton organization", "id": "GO:0051495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051495", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "membrane organization", "id": "GO:0061024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061024", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "regulation of actin filament polymerization", "id": "GO:0030833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030833", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" }, { "name": "neuromuscular synaptic transmission", "id": "GO:0007274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007274", "evidence": [ { "database": "UniProtKB", "id": "E1BBA0", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1371, "end_pos": 1373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 634, "end_pos": 636, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" }, { "id": "PS50115", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arf-GAP", "eco_id": "ECO_0000259", "start_pos": 482, "end_pos": 613, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 289, "end_pos": 381, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" }, { "id": "PS50200", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-associating", "eco_id": "ECO_0000259", "start_pos": 1121, "end_pos": 1214, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 911, "end_pos": 1092, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA0" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 68, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 189, 747 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1371, "end_pos": 1373 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 634, "end_pos": 636 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBZ3-1", "uniprot_ac": "E1BBZ3", "uniprot_id": "E1BBZ3_BOVIN", "mass": { "chemical_mass": 109379.0, "monoisotopic_mass": 109379.0 }, "refseq": { "ac": "XP_005201745", "name": "polyhomeotic-like protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201745" }, "gene_names": [ { "name": "PHC3", "type": "recommended", "evidence": [ { "id": "E1BBZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ] }, { "name": "PHC3", "type": "synonym", "evidence": [ { "id": "XP_005201745", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201745" } ] } ], "protein_names": [ { "name": "Polyhomeotic homolog 3", "type": "synonym", "evidence": [ { "id": "E1BBZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3/entry#names_and_taxonomy" } ] }, { "name": "polyhomeotic-like protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201745", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201745" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHC3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3", "locus": { "chromosome": "1", "start_pos": 97272236, "end_pos": 97196014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013938", "url": "https://www.ensembl.org/id/ENSBTAG00000013938" } ] } } ], "crossref": [ { "id": "E1BBZ3", "url": "https://alphafold.ebi.ac.uk/entry/E1BBZ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09577", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09577", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534916", "url": "https://www.ncbi.nlm.nih.gov/gene/534916", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BBZ3", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BBZ3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038603", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534916", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534916", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DRHAVQX", "url": "https://omabrowser.org/oma/group/DRHAVQX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LM05", "url": "https://www.orthodb.org/?gene=A0A3Q1LM05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBA7", "url": "https://www.orthodb.org/?gene=A0A3Q1MBA7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBZ3", "url": "https://www.orthodb.org/?gene=E1BBZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12247:SF88", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12247:SF88", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21319", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21319", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559580", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4570464", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8939243", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939243", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8943724", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005201745", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201745", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM05", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM05-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUV4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBA7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF63", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF63-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 1012, "header": "tr|E1BBZ3-1|E1BBZ3_BOVIN Isoform 1 of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=4 CANONICAL=E1BBZ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LM05-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM05/entry", "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 943, "header": "tr|A0A3Q1LM05-1|E1BBZ3_BOVIN Computationally mapped isoform of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=2 CANONICAL=E1BBZ3-1" }, "locus": { "chromosome": "1", "start_pos": 97271655, "end_pos": 97196214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071538.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071538.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057841.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057841.2" } ] } }, { "isoform_ac": "A0A3Q1LUV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUV4/entry", "sequence": { "sequence": "VLSARFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 996, "header": "tr|A0A3Q1LUV4-1|E1BBZ3_BOVIN Computationally mapped isoform of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=2 CANONICAL=E1BBZ3-1" }, "locus": { "chromosome": "1", "start_pos": 97271655, "end_pos": 97198704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066397.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066397.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059023.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059023.2" } ] } }, { "isoform_ac": "A0A3Q1MBA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBA7/entry", "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 996, "header": "tr|A0A3Q1MBA7-1|E1BBZ3_BOVIN Computationally mapped isoform of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=2 CANONICAL=E1BBZ3-1" }, "locus": { "chromosome": "1", "start_pos": 97271655, "end_pos": 97196214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073548.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073548.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067954.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067954.2" } ] } }, { "isoform_ac": "A0A3Q1MD83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD83/entry", "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPAQLGIFSYPPSR", "length": 973, "header": "tr|A0A3Q1MD83-1|E1BBZ3_BOVIN Computationally mapped isoform of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=1 CANONICAL=E1BBZ3-1" }, "locus": { "chromosome": "1", "start_pos": 97266226, "end_pos": 97196214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066794.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066794.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066792.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066792.1" } ] } }, { "isoform_ac": "A0A3Q1MF63-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF63/entry", "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 910, "header": "tr|A0A3Q1MF63-1|E1BBZ3_BOVIN Computationally mapped isoform of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=2 CANONICAL=E1BBZ3-1" }, "locus": { "chromosome": "1", "start_pos": 97271655, "end_pos": 97196214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069915.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069915.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072824.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072824.2" } ] } }, { "isoform_ac": "E1BBZ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3/entry", "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNPGTSSVSTTNSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPSSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLAMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTTQLNLSSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESEDCVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSVPSVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKRRPVLDNQVINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDAVPSAMTTRLRRQSERERERELRDVRMRKMPENSGLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 1012, "header": "tr|E1BBZ3-1|E1BBZ3_BOVIN Isoform 1 of Polyhomeotic homolog 3 OS=Bos taurus OX=9913 GN=PHC3 PE=4 SV=4 CANONICAL=E1BBZ3-1" }, "locus": { "chromosome": "1", "start_pos": 97271655, "end_pos": 97196214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018519.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018519.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018519.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018519.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 146, "start_aa": "Thr", "end_pos": 146, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr146", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 650, "start_aa": "Thr", "end_pos": 650, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr650", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534916", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534916", "resource": "KEGG Pathway" }, { "id": "R-BTA-2559580", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559580", "resource": "Reactome", "description": "Oxidative Stress Induced Senescence" }, { "id": "R-BTA-3108214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "resource": "Reactome", "description": "SUMOylation of DNA damage response and repair proteins" }, { "id": "R-BTA-3899300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "resource": "Reactome", "description": "SUMOylation of transcription cofactors" }, { "id": "R-BTA-4551638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "resource": "Reactome", "description": "SUMOylation of chromatin organization proteins" }, { "id": "R-BTA-4570464", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "resource": "Reactome", "description": "SUMOylation of RNA binding proteins" }, { "id": "R-BTA-8939243", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939243", "resource": "Reactome", "description": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" }, { "id": "R-BTA-8943724", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8943724", "resource": "Reactome", "description": "Regulation of PTEN gene transcription" }, { "id": "R-BTA-8953750", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "resource": "Reactome", "description": "Transcriptional Regulation by E2F6" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G4B4-1", "protein_name": "Polyhomeotic homolog 3", "gene_name": "Phc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEAEFKDHSTAMESEPSSGTSVSTTASSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLMSRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQKLGVLSSSQNGPPKSAGQTQSLTICHNKTTVTSSKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPSQDPPPSQHCIPLPNHGLSPASSNAQSQQHCSPIQSHPPPLTVSPSQAQSAQQSVVVSPPPAHSPSQSPTIIIHPQALVQPHPLVSSALHTGPNLQQATADQVQSTAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPTSHQQYSTLQSSPIPIATPPQMSASPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEERPEESDECARMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPTHVSAPAPPLLMPAASTRSSSTSLASSTPSLENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVVNSVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPEGAAREHILRQLPITYPSAEEDLASRDDPVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLLKEDHLMSTMNMKLGPALKICARINSLKDS", "length": 995 }, "evidence": [ { "id": "E1BBZ3", "url": "https://omabrowser.org/oma/group/E1BBZ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LJU0-1", "protein_name": "Polyhomeotic homolog 3", "gene_name": "PHC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEAEFKDHSTAMDSEPNSGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPPTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTNQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYPPIQPHPLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQNPTQDPPPSQHCIPLQNHGLPPAPSSAQSQHCSPIQSHPPPLTMSPSQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGSNLQQSTANQVQPTAQLNLPSHLPLPASPVVHIGPVQQSTLVSPGQQIVSPTSHQQYSALQSSPIPIATPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPSASVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGREDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMPSSIPNVENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEHPVKKRPILDNQMINSVCVQPELQNNAKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFTLSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPLTYPSAEEDLASHEDSVPSAMTTRLRRQSERERERELRDVRMRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 995 }, "evidence": [ { "id": "E1BBZ3", "url": "https://omabrowser.org/oma/group/E1BBZ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8CHP6-1", "protein_name": "Polyhomeotic-like protein 3", "gene_name": "Phc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSEPSSGTSVSTTASSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSILSASPAPAQLMNRSQTSSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQKLGVLSSSQNGSPKSAGQTQSLTICHNKTTVTSSKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPPKVSHHQLLLQQQQQQIQPITLQSPSQDPPPSQHCIPLPNHGLSPAPSNAQPQHCSPVQSHPPPLTVSPNQAQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQTGPNLQQAAADQVQSTAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQMVSPTSHQQYSALQSSPIPIATPPQMSASPPAQLPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECARMDRTPPPPTLSPAAVTVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPTHASAPAPPLLIPAASTRSSSTSLASSTPSLENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVVNSVCVQPELQNNTKHADNSSDTEIEDMMAEETLEEMDSELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPEGAAREHILRQLPITYPSAEEDVASHEDPVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLLKEDHLMSAMNMKLGPALKICARINSLKDS", "length": 981 }, "evidence": [ { "id": "E1BBZ3", "url": "https://omabrowser.org/oma/group/E1BBZ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NDX5-1", "protein_name": "Polyhomeotic-like protein 3", "gene_name": "PHC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLILQQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPSPLTVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTANQVQATAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVINSVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDSVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES", "length": 983 }, "evidence": [ { "id": "E1BBZ3", "url": "https://omabrowser.org/oma/group/E1BBZ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" }, { "name": "PRC1 complex", "id": "GO:0035102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035102", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 706, "end_pos": 708, "annotation": "n_glycosylation_sequon" }, { "start_pos": 789, "end_pos": 791, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" }, { "start_pos": 860, "end_pos": 862, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" }, { "id": "PS51024", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FCS-type", "eco_id": "ECO_0000259", "start_pos": 805, "end_pos": 839, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ3" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 948, "end_pos": 1012, "start_aa": "Trp", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 146, 650 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 227, "end_pos": 229 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 706, "end_pos": 708 }, { "start_pos": 789, "end_pos": 791 }, { "start_pos": 842, "end_pos": 844 }, { "start_pos": 860, "end_pos": 862 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB27-1", "uniprot_ac": "E1BB27", "uniprot_id": "E1BB27_BOVIN", "mass": { "chemical_mass": 108911.0, "monoisotopic_mass": 108911.0 }, "refseq": { "ac": "NP_001179558", "name": "disks large-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179558" }, "gene_names": [ { "name": "DLGAP1", "type": "recommended", "evidence": [ { "id": "E1BB27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ] }, { "name": "DLGAP1", "type": "synonym", "evidence": [ { "id": "NP_001179558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179558" } ] } ], "protein_names": [ { "name": "DLG associated protein 1", "type": "synonym", "evidence": [ { "id": "E1BB27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB27/entry#names_and_taxonomy" } ] }, { "name": "discs, large homolog-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179558" } ] }, { "name": "disks large-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179558", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179558" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DLGAP1", "url": "https://www.uniprot.org/uniprotkb/E1BB27", "locus": { "chromosome": "24", "start_pos": 37577937, "end_pos": 38242626, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005372", "url": "https://www.ensembl.org/id/ENSBTAG00000005372" } ] } } ], "crossref": [ { "id": "E1BB27", "url": "https://alphafold.ebi.ac.uk/entry/E1BB27", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005372", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005372", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526435", "url": "https://www.ncbi.nlm.nih.gov/gene/526435", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526435", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526435", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LP85", "url": "https://www.orthodb.org/?gene=A0A3Q1LP85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MV08", "url": "https://www.orthodb.org/?gene=A0A3Q1MV08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N626", "url": "https://www.orthodb.org/?gene=A0A3Q1N626", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NFM4", "url": "https://www.orthodb.org/?gene=A0A3Q1NFM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BB27", "url": "https://www.orthodb.org/?gene=E1BB27", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12353:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12353:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03359", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03359", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6794361", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6794361", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179558", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV08", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV08-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N626", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N626", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N626-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N626-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB27-1", "url": "https://www.uniprot.org/uniprotkb/E1BB27-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGLSGSRSHHHGVTCDSACDSLSHHADRKPYLLSPVEHHPADHPYYTQRTSFQAECVGPFSDPLASSTFPRRHYTSQQELKDECALVPRTLATKANRIPANLLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSKGSVNGGKASPDETQTVRYGKRSKSKERRPEPKPRNNTSPGWWSSDDNLDGDMCIYHSPSGVMTMGRCPDRSASQYFMEAYNTISEQAVKASRSNNDVKCSTCANLPVTLDAPLLKKSAWSSTLTVSRAREVYQKASVNMDQAMVKSESCQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNATTVTTTAAMATVTAEDRKKDHFKKNRCLSIGIQVDDAEEPEKTGGNKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPVARQFSRDASTSTVSIQGSGNHYHACAVDEDFDADFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEEILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL", "length": 977, "header": "tr|E1BB27-1|E1BB27_BOVIN Isoform 1 of DLG associated protein 1 OS=Bos taurus OX=9913 GN=DLGAP1 PE=3 SV=2 CANONICAL=E1BB27-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP85/entry", "sequence": { "sequence": "MDLKTLKLFNSQLRCGWLLYIWNRAFMAHLRVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTGVIKLSSAVEVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNATTVTTTAAMATVTAEDRKKDHFKKNRCLSIGIQVDDAEEPEKTGGNKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPVARQFSRDASTSTVSIQGSGNHYHACAVDEDFDADFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEEILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL", "length": 699, "header": "tr|A0A3Q1LP85-1|E1BB27_BOVIN Computationally mapped isoform of DLG associated protein 1 OS=Bos taurus OX=9913 GN=DLGAP1 PE=3 SV=2 CANONICAL=E1BB27-1" }, "locus": { "chromosome": "24", "start_pos": 37871462, "end_pos": 37578074, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070987.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070987.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058725.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058725.2" } ] } }, { "isoform_ac": "A0A3Q1MV08-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV08/entry", "sequence": { "sequence": "MIDLFKAEWVSSVCVQVSRNGRIDQSKLKRLQGHLCQVAFVKLKAVWSRKAVLPAAKKMQRSRVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNATTVTTTAAMATVTAEDRKKDHFKKNRCLSIGIQVDDAEEPEKTGGNKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPVARQFSRDASTSTVSIQGSGNHYHACAVDEDFDADFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEEILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKVEQCRFCMVHLKTCTNTGQSK", "length": 673, "header": "tr|A0A3Q1MV08-1|E1BB27_BOVIN Computationally mapped isoform of DLG associated protein 1 OS=Bos taurus OX=9913 GN=DLGAP1 PE=3 SV=2 CANONICAL=E1BB27-1" }, "locus": { "chromosome": "24", "start_pos": 37870990, "end_pos": 37581181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084157.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084157.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074600.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074600.2" } ] } }, { "isoform_ac": "A0A3Q1N626-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N626/entry", "sequence": { "sequence": "MIDLFKAEWVSSVCVQVSRNGRIDQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTGVIKLSSAVEVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNATTVTTTAAMATVTAEDRKKDHFKKNRCLSIGIQVDDAEEPEKTGGNKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPVARQFSRDASTSTVSIQGSGNHYHACAVDEDFDADFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEEILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL", "length": 693, "header": "tr|A0A3Q1N626-1|E1BB27_BOVIN Computationally mapped isoform of DLG associated protein 1 OS=Bos taurus OX=9913 GN=DLGAP1 PE=3 SV=2 CANONICAL=E1BB27-1" }, "locus": { "chromosome": "24", "start_pos": 37870990, "end_pos": 37578074, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076645.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076645.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065845.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065845.2" } ] } }, { "isoform_ac": "A0A3Q1NFM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM4/entry", "sequence": { "sequence": "MNLLFHKDILFGISANKVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNATTVTTTAAMATVTAEDRKKDHFKKNRCLSIGIQVDDAEEPEKTGGNKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPVARQFSRDASTSTVSIQGSGNHYHACAVDEDFDADFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEEILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKVEQCRFCMVHLKTCTNTGQSK", "length": 627, "header": "tr|A0A3Q1NFM4-1|E1BB27_BOVIN Computationally mapped isoform of DLG associated protein 1 OS=Bos taurus OX=9913 GN=DLGAP1 PE=3 SV=2 CANONICAL=E1BB27-1" }, "locus": { "chromosome": "24", "start_pos": 37837002, "end_pos": 37581181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068097.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068097.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070464.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070464.2" } ] } }, { "isoform_ac": "E1BB27-1", "url": "https://www.uniprot.org/uniprotkb/E1BB27/entry", "sequence": { "sequence": "MKGLSGSRSHHHGVTCDSACDSLSHHADRKPYLLSPVEHHPADHPYYTQRTSFQAECVGPFSDPLASSTFPRRHYTSQQELKDECALVPRTLATKANRIPANLLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSKGSVNGGKASPDETQTVRYGKRSKSKERRPEPKPRNNTSPGWWSSDDNLDGDMCIYHSPSGVMTMGRCPDRSASQYFMEAYNTISEQAVKASRSNNDVKCSTCANLPVTLDAPLLKKSAWSSTLTVSRAREVYQKASVNMDQAMVKSESCQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNATTVTTTAAMATVTAEDRKKDHFKKNRCLSIGIQVDDAEEPEKTGGNKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPVARQFSRDASTSTVSIQGSGNHYHACAVDEDFDADFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEEILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL", "length": 977, "header": "tr|E1BB27-1|E1BB27_BOVIN Isoform 1 of DLG associated protein 1 OS=Bos taurus OX=9913 GN=DLGAP1 PE=3 SV=2 CANONICAL=E1BB27-1" }, "locus": { "chromosome": "24", "start_pos": 37876428, "end_pos": 37578074, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007067.8", "url": "https://www.ensembl.org/id/ENSBTAT00000007067.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007067.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007067.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526435", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526435", "resource": "KEGG Pathway" }, { "id": "R-BTA-6794361", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6794361", "resource": "Reactome", "description": "Neurexins and neuroligins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signaling", "id": "GO:0023052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023052", "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "pmid": "" }, { "name": "postsynaptic specialization", "id": "GO:0099572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099572", "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "E1BB27", "url": "https://www.uniprot.org/uniprotkb/E1BB27" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 883, "end_pos": 885, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB27-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 977, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB27-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB27" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 588, "end_pos": 590 }, { "start_pos": 621, "end_pos": 623 }, { "start_pos": 883, "end_pos": 885 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B777-1", "uniprot_ac": "E1B777", "uniprot_id": "E1B777_BOVIN", "mass": { "chemical_mass": 46141.0, "monoisotopic_mass": 46141.0 }, "refseq": { "ac": "NP_001193205", "name": "WAS/WASL-interacting protein family member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193205" }, "gene_names": [ { "name": "WIPF2", "type": "recommended", "evidence": [ { "id": "E1B777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B777" } ] }, { "name": "WIPF2", "type": "synonym", "evidence": [ { "id": "NP_001193205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193205" } ] } ], "protein_names": [ { "name": "WAS/WASL interacting protein family member 2", "type": "synonym", "evidence": [ { "id": "E1B777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B777/entry#names_and_taxonomy" } ] }, { "name": "WAS/WASL-interacting protein family member 2", "type": "synonym", "evidence": [ { "id": "NP_001193205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193205" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B777", "url": "https://www.uniprot.org/uniprotkb/E1B777" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WIPF2", "url": "https://www.uniprot.org/uniprotkb/E1B777", "locus": { "chromosome": "19", "start_pos": 40526914, "end_pos": 40511307, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038126", "url": "https://www.ensembl.org/id/ENSBTAG00000038126" } ] } } ], "crossref": [ { "id": "E1B777", "url": "https://alphafold.ebi.ac.uk/entry/E1B777", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038126", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038126", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616849", "url": "https://www.ncbi.nlm.nih.gov/gene/616849", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616849", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616849", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DNTDCSA", "url": "https://omabrowser.org/oma/group/DNTDCSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPA0", "url": "https://www.orthodb.org/?gene=A0A3Q1LPA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B777", "url": "https://www.orthodb.org/?gene=E1B777", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF02205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193205", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B777", "url": "https://www.uniprot.org/uniprotkb/E1B777", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B777-1", "url": "https://www.uniprot.org/uniprotkb/E1B777-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPIPPPPPPPPGPPPPPTFHQANTEPPKLSRDEQRGRGALLQDICKGTKLKKVTNVNDRSAPILEKPKGSSGGYGSGAAALQAKGGLFQGGVPKLRPVGAKDSSENLAGKPVLQVPSSRAAAPRPPGTTAIGRPQDDTDSSRASLPELPRTQRPSLPDLSRPNPTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSNKAAAYNREKPLPPTPGQRLHPGREGPSAPPPVKPPPSPVNVRSGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPARGLAPPPPTSASPSSQSNRPPPPTRDPPSRGAAPPPPPPMIRNGARDAPPPPPPYRVHGSEPLSRGKPPPPPSRTPAGPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPQPPILR", "length": 439, "header": "tr|E1B777-1|E1B777_BOVIN Isoform 1 of WAS/WASL interacting protein family member 2 OS=Bos taurus OX=9913 GN=WIPF2 PE=4 SV=1 CANONICAL=E1B777-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPA0/entry", "sequence": { "sequence": "MPIPPPPPPPPGPPPPPTFHQANTEPPKLSRDEQRGRGALLQDICKGTKLKKVTNVNDRSAPILETPPPPPPMIRNGARDAPPPPPPYRVHGSEPLSRGKPPPPPSRTPAGPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPQPPILR", "length": 181, "header": "tr|A0A3Q1LPA0-1|E1B777_BOVIN Computationally mapped isoform of WAS/WASL interacting protein family member 2 OS=Bos taurus OX=9913 GN=WIPF2 PE=4 SV=2 CANONICAL=E1B777-1" }, "locus": { "chromosome": "19", "start_pos": 40526657, "end_pos": 40511378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068851.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068851.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058831.2" } ] } }, { "isoform_ac": "E1B777-1", "url": "https://www.uniprot.org/uniprotkb/E1B777/entry", "sequence": { "sequence": "MPIPPPPPPPPGPPPPPTFHQANTEPPKLSRDEQRGRGALLQDICKGTKLKKVTNVNDRSAPILEKPKGSSGGYGSGAAALQAKGGLFQGGVPKLRPVGAKDSSENLAGKPVLQVPSSRAAAPRPPGTTAIGRPQDDTDSSRASLPELPRTQRPSLPDLSRPNPTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSNKAAAYNREKPLPPTPGQRLHPGREGPSAPPPVKPPPSPVNVRSGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPARGLAPPPPTSASPSSQSNRPPPPTRDPPSRGAAPPPPPPMIRNGARDAPPPPPPYRVHGSEPLSRGKPPPPPSRTPAGPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPQPPILR", "length": 439, "header": "tr|E1B777-1|E1B777_BOVIN Isoform 1 of WAS/WASL interacting protein family member 2 OS=Bos taurus OX=9913 GN=WIPF2 PE=4 SV=1 CANONICAL=E1B777-1" }, "locus": { "chromosome": "19", "start_pos": 40526657, "end_pos": 40511378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013695.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013695.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013695.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013695.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 212, "start_aa": "Thr", "end_pos": 212, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr212", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 300, "start_aa": "Thr", "end_pos": 300, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr300", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616849", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616849", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8TF74-1", "protein_name": "WAS/WASL-interacting protein family member 2", "gene_name": "WIPF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPLPPILR", "length": 440 }, "evidence": [ { "id": "E1B777", "url": "https://omabrowser.org/oma/group/E1B777/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1B777", "url": "https://www.uniprot.org/uniprotkb/E1B777" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B777-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 439, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B777-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B777" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 212, 300 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 270, "end_pos": 272 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8H2-1", "uniprot_ac": "E1B8H2", "uniprot_id": "E1B8H2_BOVIN", "mass": { "chemical_mass": 52511.0, "monoisotopic_mass": 52511.0 }, "refseq": { "ac": "NP_001180140", "name": "cerebral cavernous malformations 2 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180140" }, "gene_names": [ { "name": "CCM2", "type": "recommended", "evidence": [ { "id": "E1B8H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H2" } ] }, { "name": "CCM2", "type": "synonym", "evidence": [ { "id": "NP_001180140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180140" } ] } ], "protein_names": [ { "name": "CCM2 scaffold protein", "type": "synonym", "evidence": [ { "id": "E1B8H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H2/entry#names_and_taxonomy" } ] }, { "name": "CCM2 scaffolding protein", "type": "synonym", "evidence": [ { "id": "NP_001180140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180140" } ] }, { "name": "cerebral cavernous malformations 2 protein", "type": "synonym", "evidence": [ { "id": "NP_001180140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180140" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8H2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCM2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2", "locus": { "chromosome": "4", "start_pos": 76550183, "end_pos": 76604039, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008090", "url": "https://www.ensembl.org/id/ENSBTAG00000008090" } ] } } ], "crossref": [ { "id": "E1B8H2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8H2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008090", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008090", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13166", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13166", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13516", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13516", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506450", "url": "https://www.ncbi.nlm.nih.gov/gene/506450", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506450", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506450", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LKTXDSS", "url": "https://omabrowser.org/oma/group/LKTXDSS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQ70", "url": "https://www.orthodb.org/?gene=A0A3Q1LQ70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8H2", "url": "https://www.orthodb.org/?gene=E1B8H2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21642", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21642", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21642:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21642:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16545", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16545", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180140", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV56", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV56-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3N3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3N3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8H2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8H2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8H2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHSNCRQRGRNQNSSREIPPQTDFPTGYPMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 476, "header": "tr|E1B8H2-1|E1B8H2_BOVIN Isoform 1 of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=2 CANONICAL=E1B8H2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ70/entry", "sequence": { "sequence": "SAQLPQGFLGGILAPWAEEARRPLQEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 469, "header": "tr|A0A3Q1LQ70-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=2 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76600972, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062304.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062304.2" } ] } }, { "isoform_ac": "A0A3Q1LV56-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV56/entry", "sequence": { "sequence": "MHSNCRQRGRNQNSSREIPPQTDFPTGYPMENENVLSCELCPRSELPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 489, "header": "tr|A0A3Q1LV56-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76587286, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074674.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074674.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059141.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059141.2" } ] } }, { "isoform_ac": "A0AAA9RTW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW1/entry", "sequence": { "sequence": "MLGQREGEHLTIFFNQIRSEQRRMHSNCRQRGRNQNSSREIPPQTDFPTGYPMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 499, "header": "tr|A0AAA9RTW1-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76593370, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097316.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097316.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076520.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076520.1" } ] } }, { "isoform_ac": "A0AAA9S3N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3N3/entry", "sequence": { "sequence": "MEEEGKKGKKREGEHLTIFFNQIRSEQRRMHSNCRQRGRNQNSSREIPPQTDFPTGYPMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 505, "header": "tr|A0AAA9S3N3-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76603468, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080547.1" } ] } }, { "isoform_ac": "A0AAA9SB52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB52/entry", "sequence": { "sequence": "MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 453, "header": "tr|A0AAA9SB52-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76603468, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132076.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132076.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082600.1" } ] } }, { "isoform_ac": "A0AAA9SMN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN2/entry", "sequence": { "sequence": "LSPKPRLSTWPSRRPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 457, "header": "tr|A0AAA9SMN2-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76602896, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091044.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091044.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084025.1" } ] } }, { "isoform_ac": "A0AAA9SWN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN7/entry", "sequence": { "sequence": "MAADLKSWRRSCSSEGQEDGLKAGQARSGPPRRAWVVPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 480, "header": "tr|A0AAA9SWN7-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76603922, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113072.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113072.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089734.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089734.1" } ] } }, { "isoform_ac": "A0AAA9TL73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL73/entry", "sequence": { "sequence": "MRKTRLDEAQAGIKIAGRNIDNLRYADDTTLMAPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 476, "header": "tr|A0AAA9TL73-1|E1B8H2_BOVIN Computationally mapped isoform of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=1 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76596063, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097746.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097746.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097695.1" } ] } }, { "isoform_ac": "E1B8H2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8H2/entry", "sequence": { "sequence": "MHSNCRQRGRNQNSSREIPPQTDFPTGYPMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKEPYETEASTFSFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRATSSTSTSTSNGNRAAGSSDDQSVPSEGDEWDRMISDISNDIEALGCSMDQDSA", "length": 476, "header": "tr|E1B8H2-1|E1B8H2_BOVIN Isoform 1 of CCM2 scaffold protein OS=Bos taurus OX=9913 GN=CCM2 PE=3 SV=2 CANONICAL=E1B8H2-1" }, "locus": { "chromosome": "4", "start_pos": 76587286, "end_pos": 76550420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033632.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033632.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033542.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033542.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506450", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506450", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZT10-1", "protein_name": "CCM2 scaffold protein", "gene_name": "Ccm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSRCSPHPLSPLSPPVCPQHLVFYLRPRLTGILQSSCLRITFLVQPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLALPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDKAKRSHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAEGSRGLSAGSLSESAVGPVEACCLVIMATESKVAAEELCSLLSQVFQIVYTESTIDFLDRAIFDGASTPTHHLSVHSDDSSTKVDMKDSYDADASTFCFPDSGDVGGLPPLPFCMQASPHSKTVSESELSTSATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCISLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSTSTTNGNRTTGSPDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA", "length": 489 }, "evidence": [ { "id": "E1B8H2", "url": "https://omabrowser.org/oma/group/E1B8H2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AA01-1", "protein_name": "CCM2 scaffolding protein", "gene_name": "CCM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "GAVAVGCSHHAHQPTSWRAVFLWSCCPPTFFREQRSNSSGWQEPGIVSPFKRVFLKGEKGRDKKAQEKVTERRPLHTVVVSLPDRVEPDILLNDYIEKEVKYLGQLTSVPGYLNPSSRTEILHLIDNAKRAHQLPGQLTQEHDAVISLSAYNIKLVWRDGEDLILRVPIHDIASVSYIRDDSAHLVVLKTAQDPGISPSQSLSAESSKALTSGSLSESGVVPVEACCLVVLATENKVTAEELCSLLSQVFQIVYTESTIDFLDRAIFDGASTPTRHMSLHSDDSSTKVDVKESYETEASTVSFPETLDAGDNSPSSFLTQQSPHIKTISESELSTTATELLQDYMMTLRTKLSSQEIQQFAMLLHEYRNGASIHEFCINLKQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRTLSTTSNSTTNGNGAAGSSDDQSVPSEEDEWDRMISHISNDIEALGCSMDRDSS", "length": 486 }, "evidence": [ { "id": "E1B8H2", "url": "https://omabrowser.org/oma/group/E1B8H2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1ST61-1", "protein_name": "CCM2 scaffold protein", "gene_name": "CCM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHGSSRQRGRNQDSSREIAAHTGFPTGCSVENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVISLSAYNVKLAWRDGEDTILRVPIHDIAAVSYVRDDASHLVVLKTAQDPGISPSQSLCAESSRGLTTGSLSESGVGPVEACCLVILAAESKVAAEELCSLLGQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDLKEPYETEASTFTFPECAHAGGVSPLSFCMQTAPHAKTVSESELSATAAELLQDYMLTLRTKLSSQEIQQFAALLHEYRDGASVHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYRRTMSSTSTSTSNGNRAAGSSDDQSAPSEGDEWDRMISDISNDIEALGCSMDPDSA", "length": 476 }, "evidence": [ { "id": "E1B8H2", "url": "https://omabrowser.org/oma/group/E1B8H2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6DRP4-1", "protein_name": "Cerebral cavernous malformations protein 2 homolog", "gene_name": "ccm2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEDVKKVKKPGIVSPFKRVFLKGEKGRDKKALEKSTERRALHTFSLSLPDHRIDPDILLNDYIEKEVKYLGQLTSVPGYLNPSSRTEVLQLIDNARKSHQLAGQLTSEQDAVVSLSAYNVKLVWRDGEDIILRVPIHDIAAVSYIRDDSLHLVVLKTAQEPGGSPCHSTEMSKSPTLSSLSESGAVLVEVCCLLVLAVDNKAAAEELCLLLSQVFQIVYTESTIDFLDRAIFDGATTPTRHLSIYSEDSSSKVDVKDVFEAEASTFSFQSSLEAGHSSSPSPTSAPASPQTKTASESELSTTAAELLQDYMTTLRTKLSSKEIQQFATLLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRYKRTTSSASDSTTNGNGAAGGSDEGTATSEGDEWDRMISDISNDIEALGSSMDQDGVPS", "length": 455 }, "evidence": [ { "id": "E1B8H2", "url": "https://omabrowser.org/oma/group/E1B8H2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8K2Y9-1", "protein_name": "Cerebral cavernous malformations protein 2 homolog", "gene_name": "Ccm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLALPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDKAKRSHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVIMATESKVAAEELCSLLSQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKDSYDADASTFCFPDSGDVGGLPPLPFCMQTSPHSKTVSESELSTSATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCISLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSTSTINGNRTTGSPDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA", "length": 453 }, "evidence": [ { "id": "E1B8H2", "url": "https://omabrowser.org/oma/group/E1B8H2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BSQ5-1", "protein_name": "Cerebral cavernous malformations 2 protein", "gene_name": "CCM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA", "length": 444 }, "evidence": [ { "id": "E1B8H2", "url": "https://omabrowser.org/oma/group/E1B8H2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vasculogenesis", "id": "GO:0001570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001570", "evidence": [ { "database": "UniProtKB", "id": "E1B8H2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "E1B8H2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1B8H2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1B8H2", "url": "https://www.uniprot.org/uniprotkb/E1B8H2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAW6-1", "uniprot_ac": "E1BAW6", "uniprot_id": "E1BAW6_BOVIN", "mass": { "chemical_mass": 56748.0, "monoisotopic_mass": 56748.0 }, "refseq": { "ac": "NP_001098727", "name": "DNA-binding protein Ikaros", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727" }, "gene_names": [ { "name": "IKZF1", "type": "recommended", "evidence": [ { "id": "E1BAW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ] }, { "name": "IKZF1", "type": "synonym", "evidence": [ { "id": "NP_001098727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727" } ] } ], "protein_names": [ { "name": "DNA-binding protein Ikaros", "type": "synonym", "evidence": [ { "id": "NP_001098727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727" } ] }, { "name": "IKAROS family zinc finger 1 (Ikaros)", "type": "synonym", "evidence": [ { "id": "NP_001098727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727" } ] }, { "name": "IKAROS family zinc finger 1", "type": "synonym", "evidence": [ { "id": "E1BAW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW6/entry#names_and_taxonomy" } ] }, { "name": "KAROS family zinc finger 1 (Ikaros)", "type": "synonym", "evidence": [ { "id": "NP_001098727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727" } ] }, { "name": "zinc finger protein, subfamily 1A, 1 (Ikaros)", "type": "synonym", "evidence": [ { "id": "NP_001098727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IKZF1", "url": "https://www.uniprot.org/uniprotkb/E1BAW6", "locus": { "chromosome": "4", "start_pos": 5505166, "end_pos": 5599848, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014016", "url": "https://www.ensembl.org/id/ENSBTAG00000014016" } ] } } ], "crossref": [ { "id": "E1BAW6", "url": "https://alphafold.ebi.ac.uk/entry/E1BAW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014016", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014016", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541154", "url": "https://www.ncbi.nlm.nih.gov/gene/541154", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541154", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541154", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LR66", "url": "https://www.orthodb.org/?gene=A0A3Q1LR66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRY3", "url": "https://www.orthodb.org/?gene=A0A3Q1LRY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGE7", "url": "https://www.orthodb.org/?gene=A0A3Q1MGE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAW6", "url": "https://www.orthodb.org/?gene=E1BAW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47034:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47034:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9940951", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098727", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRY3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGE7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U193", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U193", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U193-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U193-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAW6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCRCEQDAQSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 515, "header": "tr|E1BAW6-1|E1BAW6_BOVIN Isoform 1 of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=1 CANONICAL=E1BAW6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR66/entry", "sequence": { "sequence": "MQRAAARADNPRTMDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 532, "header": "tr|A0A3Q1LR66-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=2 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5599768, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068783.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068783.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059480.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059480.2" } ] } }, { "isoform_ac": "A0A3Q1LRY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY3/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLVAYGADGFRDFHAIIPNSFSPGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 497, "header": "tr|A0A3Q1LRY3-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=2 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075867.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075867.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059776.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059776.2" } ] } }, { "isoform_ac": "A0A3Q1MGE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGE7/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLVAYGADGFRDFHAIIPNSFSRERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 452, "header": "tr|A0A3Q1MGE7-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=2 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071166.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071166.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073329.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073329.2" } ] } }, { "isoform_ac": "A0A3Q1MIX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIX7/entry", "sequence": { "sequence": "MDADEGQDMSQVSAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 479, "header": "tr|A0A3Q1MIX7-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=2 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086046.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086046.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074287.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074287.2" } ] } }, { "isoform_ac": "A0AAA9SF91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF91/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 474, "header": "tr|A0AAA9SF91-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=1 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089029.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089029.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082512.1" } ] } }, { "isoform_ac": "A0AAA9SNS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS1/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 509, "header": "tr|A0AAA9SNS1-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=1 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127786.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127786.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085543.1" } ] } }, { "isoform_ac": "A0AAA9SXL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL0/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLVAYGADGFRDFHAIIPNSFSPGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 539, "header": "tr|A0AAA9SXL0-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=1 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124260.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124260.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090093.1" } ] } }, { "isoform_ac": "A0AAA9SYF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYF7/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 376, "header": "tr|A0AAA9SYF7-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=2 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114276.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114276.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088375.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088375.2" } ] } }, { "isoform_ac": "A0AAA9U193-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U193/entry", "sequence": { "sequence": "MDADEGQDMSQVSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 432, "header": "tr|A0AAA9U193-1|E1BAW6_BOVIN Computationally mapped isoform of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=2 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5584730, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104291.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104291.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103530.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103530.2" } ] } }, { "isoform_ac": "E1BAW6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAW6/entry", "sequence": { "sequence": "MCRCEQDAQSGKESPPVSDTPDDSDEPMPVPEDLSTTSGGQQSSKSERGLAGNVKVETQSDEENGRACEVNGEECAEDLRMLDASGEKMNGSHSVQGSKALSGAGGIRLPNGKLKCDVCGIICIGPNVLMVHKRSHTERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLQSMGLPGTLYPVIKEETNHSEMAEDLCKMGSDRSLVLDRLASNVAKRKSSMPQKFVGDKCLSELPYDGSASYEKENEMMQTHVMDQAINNAISYLGAESLRPLVQTPPGSSDVVPVLSPMYQLHKPHGEGPARSNHSAQDGAVENLLLLSKAKSASSEREASPSNSCQDSTDTESNTEEQRGGLIYLTNHINPHARNGLSIKEEHAAYDVLRAASEGPPDALRVIGTSGEALKVYRCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS", "length": 515, "header": "tr|E1BAW6-1|E1BAW6_BOVIN Isoform 1 of IKAROS family zinc finger 1 OS=Bos taurus OX=9913 GN=IKZF1 PE=3 SV=1 CANONICAL=E1BAW6-1" }, "locus": { "chromosome": "4", "start_pos": 5576723, "end_pos": 5506170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018632.3", "url": "https://www.ensembl.org/id/ENSBTAT00000018632.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018632.2", "url": "https://www.ensembl.org/id/ENSBTAP00000018632.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541154", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541154", "resource": "KEGG Pathway" }, { "id": "R-BTA-9940951", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "resource": "Reactome", "description": "Interaction of NuRD complexes with transcription factors" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "lymphocyte differentiation", "id": "GO:0030098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030098", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BAW6", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAW6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 515, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAW6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAW6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 168, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 241, "end_pos": 243 }, { "start_pos": 358, "end_pos": 360 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAY5-1", "uniprot_ac": "E1BAY5", "uniprot_id": "E1BAY5_BOVIN", "mass": { "chemical_mass": 82375.0, "monoisotopic_mass": 82375.0 }, "refseq": { "ac": "NP_001192596", "name": "F-box only protein 30", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192596" }, "gene_names": [ { "name": "FBXO30", "type": "recommended", "evidence": [ { "id": "E1BAY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAY5" } ] }, { "name": "FBXO30", "type": "synonym", "evidence": [ { "id": "NP_001192596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192596" } ] } ], "protein_names": [ { "name": "F-box only protein 30", "type": "recommended", "evidence": [ { "id": "E1BAY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAY5/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 30", "type": "synonym", "evidence": [ { "id": "NP_001192596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192596" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR86#function" }, { "database": "UniProtKB", "id": "ARBA00057742", "url": "https://www.uniprot.org/uniprotkb/ARBA00057742#function" }, { "database": "UniProtKB", "id": "E1BAY5", "url": "https://www.uniprot.org/uniprotkb/E1BAY5#function" }, { "database": "UniProtKB", "id": "A0A3Q1M360", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M360#function" }, { "database": "UniProtKB", "id": "A0A3Q1MP30", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP30#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAY5", "url": "https://www.uniprot.org/uniprotkb/E1BAY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO30", "url": "https://www.uniprot.org/uniprotkb/E1BAY5", "locus": { "chromosome": "9", "start_pos": 83069104, "end_pos": 83085562, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005376", "url": "https://www.ensembl.org/id/ENSBTAG00000005376" } ] } } ], "crossref": [ { "id": "E1BAY5", "url": "https://alphafold.ebi.ac.uk/entry/E1BAY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005376", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005376", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22174", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22174", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539435", "url": "https://www.ncbi.nlm.nih.gov/gene/539435", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539435", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539435", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SSWQVKE", "url": "https://omabrowser.org/oma/group/SSWQVKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M360", "url": "https://www.orthodb.org/?gene=A0A3Q1M360", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAY5", "url": "https://www.orthodb.org/?gene=E1BAY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15933", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15933", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15933:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15933:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15965", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15965", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M360", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M360", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M360-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M360-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP30", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAY5", "url": "https://www.uniprot.org/uniprotkb/E1BAY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAY5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHACKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLETCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSEPREQISVKPSVSEIPHTNGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLSTSLCASLNEMNEEQKAREGLQNRNQKDQDHLYEDEMGAVGGIDHKDTSQNAQLEQNGSSDLLCDFNASSYGTSALCNGFPLEDICAQVIEQNQDLHTDSKQSNLTNGECVASGGSSEPSSSLLVAAQVREVIPPNALPNGTVQHILVPDDDEDLCWKKVDLGDLRNVDVLSFSHPPSFKFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADVYHVDFGTQTFSLPSTILATDTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRPMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDHHLRSFGVQPSVSTVLVEPARNCVLGLHSDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVDEWKFADILSMADHLKKCSYNIVEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 745, "header": "tr|E1BAY5-1|E1BAY5_BOVIN Isoform 1 of F-box only protein 30 OS=Bos taurus OX=9913 GN=FBXO30 PE=4 SV=1 CANONICAL=E1BAY5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR86/entry", "sequence": { "sequence": "MESVSYLAFAAGLAIMEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHACKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLETCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSEPREQISVKPSVSEIPHTNGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLSTSLCASLNEMNEEQKAREGLQNRNQKDQDHLYEDEMGAVGGIDHKDTSQNAQLEQNGSSDLLCDFNASSYGTSALCNGFPLEDICAQVIEQNQDLHTDSKQSNLTNGECVASGGSSEPSSSLLVAAQVREVIPPNALPNGTVQHILVPDDDEDLCWKKVDLGDLRNVDVLSFSHPPSFKFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADVYHVDFGTQTFSLPSTILATDTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRPMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDHHLRSFGVQPSVSTVLVEPARNCVLGLHSDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVDEWKFADILSMADHLKKCSYNIVEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 760, "header": "tr|A0A3Q1LR86-1|E1BAY5_BOVIN Computationally mapped isoform of F-box only protein 30 OS=Bos taurus OX=9913 GN=FBXO30 PE=4 SV=1 CANONICAL=E1BAY5-1" }, "locus": { "chromosome": "9", "start_pos": 83081072, "end_pos": 83070997, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085637.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085637.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057546.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057546.2" } ] } }, { "isoform_ac": "A0A3Q1M360-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M360/entry", "sequence": { "sequence": "MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHACKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLETCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSEPREQISVKPSVSEIPHTNGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLSTSLCASLNEMNEEQKAREGLQNRNQKDQDHLYEDEMGAVGGIDHKDTSQNAQLEQNGSSDLLCDFNASSYGTSALCNGFPLEDICAQVIEQNQDLHTDSKQSNLTNGECVASGGSSEPSSSLLVAAQVREVIPPNALPNGTVQHILVPDDDEDLCWKKVDLGDLRNVDVLSFSHPPSFKFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADVYHVDFGTQTFSLPSTILATDTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRPMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDHHLRSFGVQPSVSTVLVEPARNCVLGLHSDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVDEWKFADILSMADHLKKCSYNIVEKREEAIPLPCMNLIFGEKKIQSTLHIWISMDSIKGWKMFGKKKFHEIPKNTT", "length": 765, "header": "tr|A0A3Q1M360-1|E1BAY5_BOVIN Computationally mapped isoform of F-box only protein 30 OS=Bos taurus OX=9913 GN=FBXO30 PE=4 SV=2 CANONICAL=E1BAY5-1" }, "locus": { "chromosome": "9", "start_pos": 83076606, "end_pos": 83070108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081154.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081154.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064507.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064507.2" } ] } }, { "isoform_ac": "A0A3Q1MP30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP30/entry", "sequence": { "sequence": "MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHACKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLETCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSEPREQISVKPSVSEIPHTNGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLSTSLCASLNEMNEEQKAREGLQNRNQKDQDHLYEDEMGAVGGIDHKDTSQNAQLEQNGSSDLLCDFNASSYGTSALCNGFPLEDICAQVIEQNQDLHTDSKQSNLTNGECVASGGSSEPSSSLLVAAQVREVIPPNALPNGTVQHILVPDDDEDLCWKKVDLGDLRNVDVLSFSHPPSFKFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADVYHVDFGTQTFSLPSTILATDTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRPMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDHHLRSFGVQPSVSTVLVEPARNCVLGLHSDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKEFDIWREENTVDPSYLDIHGFNQRMENVWKKKIP", "length": 712, "header": "tr|A0A3Q1MP30-1|E1BAY5_BOVIN Computationally mapped isoform of F-box only protein 30 OS=Bos taurus OX=9913 GN=FBXO30 PE=4 SV=1 CANONICAL=E1BAY5-1" }, "locus": { "chromosome": "9", "start_pos": 83076606, "end_pos": 83070130, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073663.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073663.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071410.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071410.2" } ] } }, { "isoform_ac": "E1BAY5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAY5/entry", "sequence": { "sequence": "MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHACKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLETCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSEPREQISVKPSVSEIPHTNGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLSTSLCASLNEMNEEQKAREGLQNRNQKDQDHLYEDEMGAVGGIDHKDTSQNAQLEQNGSSDLLCDFNASSYGTSALCNGFPLEDICAQVIEQNQDLHTDSKQSNLTNGECVASGGSSEPSSSLLVAAQVREVIPPNALPNGTVQHILVPDDDEDLCWKKVDLGDLRNVDVLSFSHPPSFKFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADVYHVDFGTQTFSLPSTILATDTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRPMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDHHLRSFGVQPSVSTVLVEPARNCVLGLHSDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVDEWKFADILSMADHLKKCSYNIVEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 745, "header": "tr|E1BAY5-1|E1BAY5_BOVIN Isoform 1 of F-box only protein 30 OS=Bos taurus OX=9913 GN=FBXO30 PE=4 SV=1 CANONICAL=E1BAY5-1" }, "locus": { "chromosome": "9", "start_pos": 83076606, "end_pos": 83070997, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007075.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007075.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007075.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007075.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539435", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539435", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ASK2-1", "protein_name": "F-box only protein 30", "gene_name": "FBXO30", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEACPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSEPREQISVKSSVSEIPHTNGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLSSSLCTSPNEINEEQNSRESLKDQDHLYADEIGAVGGIDHNDTSQNAQSEQNGSSDLLCDLDASSYGSSALCNGFPLEDICTQVIEQNQNLHGDSKQNNLTNGECVASDGISEPSSSLSVAAQLREVIPANALPNGTVQHILMPDDDEGDLCWRKVDLGDLRNMDVLSFNHPPSFKFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMVDVYHIDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPSVSTVLVEPARNCVLGLHNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKKCSYNIVEKREEAVPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 741 }, "evidence": [ { "id": "E1BAY5", "url": "https://omabrowser.org/oma/group/E1BAY5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XGI2-1", "protein_name": "F-box only protein 30", "gene_name": "FBXO30", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEHQQHLHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKAEEHRILCPLERVPCLNSGFGCPFVVARNKIADHLEVCPASVVCCTMEWNRWPVSYADRKSYENLSKDVDEVEQLDMALALQDQRMLLESLKVATMMSKAADQMSESREQTSVKTNAPDTVCSNGLIPVDEESYGALYQATVETTRSLAAALDILNTATRDISMLNSRLCASPQEMKEDTEIKEQASNGIIQDSKSDREYPDEENTGAVGGITFDSLHQNSQMEQNGSSDICYDAIQNRDLNLNLTNSSLLCNGFHVENECSKVLDQNEDLGVSNSKSFSVANGECTASHDDEALQSCSSFPVTSQLKEVIPSDHLVNGNVNHMLLPHNANEEEILERQVEQERLRNVDVFSIMRHRSYKFLWSAPKEDKAVDTSDLEITEDPMGLQGIDLITAALLFCLGDSPGGRGISESRTVDVYRVDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLEYVARYQTKQRSMFTFVCGQLFRRNEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPSISTVLVEPAKSCLIGLHNDHLSSLPFEVLQHIANFLDGFSLCQLSRVSRLMRDVCGSLLQARGMVILLWEKRKYPDGSSSWQIKEKVWRFSTAFCTVNEWKFADIVSMADHLKKCSYNAVERREEAVPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 756 }, "evidence": [ { "id": "E1BAY5", "url": "https://omabrowser.org/oma/group/E1BAY5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HXS5-1", "protein_name": "F-box only protein 30", "gene_name": "Fbxo30", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEEEVQQHSHCVNCISRRCMTRPEPGIACDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSNFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKISEPREQISVKSSVQEIPCTNGLVSVDEESYGALYQATVETTRSLAAALDILNSATRDIGMLNTSLSATTDEMDENNRESFQERNLKSQDHLYEEEMGAVGGVDHNGISQNAQSEQNGSSDLLCDLSTSSLGTAALCNGFPLENMCSQIKEQDQKFPGDSIDNNIENGECAAADGTSEPSSSLLVAAQLREVIPFSALPDSTFQHILMTDEDDDEDLYWKKVDLGDVKDVDDSPFSHAPSFKFLSNSWYIPKEDKAVDTSDLEVAEDPMDLQGIDLITAALLFCLGDSPGGRGISDSRMVDVYHIDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPCVSTVLEEPSRNCVLGLRSDHLSSLPFEVLQHIAGFLDGFSLCQLACVSRLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKTCSYNVIEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 745 }, "evidence": [ { "id": "E1BAY5", "url": "https://omabrowser.org/oma/group/E1BAY5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5XI67-1", "protein_name": "F-box only protein 30", "gene_name": "Fbxo30", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEEVQQHSHCVNCVSRRCMTRPEPGVSCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSNFGCPFTLARNKVAEHLEMCPASVVCCTMEWNRWPVSYSDRKSYESLSRDADEVSQLDMALALQDQRMLLESLKVATMMSKATGKISKPREQISVNSSVQEVPRANGLVSADEESYGALYEATVETTRSLAAALDILNSATRDIGMLNTSLQGTTNEMDEESNRESSQDRNAKDQDHLDEGEIGAVGGIDYTGTSQNAQAEQNGSSDLLCNLNTSSYDTSALCNGFPLEKMCTQVKDQDQNFHGDSTESNITNGDCVEADGTSEPPSSLLVAEQLKEGSALPDSTYQHILMPDEDDDEDLCWKKDLGDSKDVNGSPLSHATSFKFLSNSWYIPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMVDVYHVDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPCVSTALEEPSRNCVLGLRSDHLSSLPFEVLQHIAGFLDGFSLCQLACVSRLMRDICGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVNDWKFADILSMADHLKKCSYNVIEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 742 }, "evidence": [ { "id": "E1BAY5", "url": "https://omabrowser.org/oma/group/E1BAY5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BJL1-1", "protein_name": "F-box only protein 30", "gene_name": "Fbxo30", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEEVQQHSHCMNCVSRRCMTRPEPGVSCDLIGCPLVCGAVFHSCKADEHRLLCPFERVACLNRNFGCPFTLARNKVAEHLEMCPASVVCCTMEWNRWPVSYSDRKSYESLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKISEPREQISVKSSVQEIPRTNGLVSVDEESYGALYQATVETTRSLAAALDILNSATRDIGMLNTSLHATANEMDEENNKESFQDKNLKDQDHLDEGEIGAVGGVDYSGTSQNAQAEQNGSSDLLCDLNPSSNGTSALCNGFPLEKMCIQVKGQDQNFHGDSTESNITNGDCVEADGTSEPSSSLVVPEQLREISPFSALPDSTFQQILMPDEDDEKDLCWKKVDLGDLKDVNGSPFSHAPSFKFLSNSWYIPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMTDVYHVDFGTQTFSLPSAILATNTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSTQGAKIIHDRHLRSFGVQPCVSTVLEEPSRNCVLGLRSDHLSSLPFEVLQHIAGFLDGFSLCQLACVSRLMRDVCGSLLQSRGMVILQWGKKKYPEGNSSWQIKEKVWRFSTAFCSVNDWKFADILSMADHLKNCSYNVIEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 746 }, "evidence": [ { "id": "E1BAY5", "url": "https://omabrowser.org/oma/group/E1BAY5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TB52-1", "protein_name": "F-box only protein 30", "gene_name": "FBXO30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSKPREQISVKSSVPEIPHANGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLNTSVPNDMDEQQNARESLEDQNLKDQDHLYEEEIGAVGGIDYNDTNQNAQSEQNGSSDLLCDLNTSSYDTSALCNGFPLENICTQVIDQNQNLHGDSKQSNLTNGDCVASSDGTSKPSSSLAVAAQLREIIPSSALPNGTVQHILMPDDEGEGELCWKKVDLGDVKNVDVLSFSHAPSFNFLSNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMADIYHIDVGTQTFSLPSAILATSTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSIQGAKIIHDRHLRSFGVQPCVSTVLVEPARNCVLGLHNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCMCVTRELTKEGRSLRSVLKPVL", "length": 745 }, "evidence": [ { "id": "E1BAY5", "url": "https://omabrowser.org/oma/group/E1BAY5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAY5", "url": "https://www.uniprot.org/uniprotkb/E1BAY5" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BAY5", "url": "https://www.uniprot.org/uniprotkb/E1BAY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 670, "end_pos": 672, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAY5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 745, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAY5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAY5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 314, "end_pos": 316 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 670, "end_pos": 672 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBC1-1", "uniprot_ac": "E1BBC1", "uniprot_id": "E1BBC1_BOVIN", "mass": { "chemical_mass": 115026.0, "monoisotopic_mass": 115026.0 }, "refseq": { "ac": "XP_002694361", "name": "FHF complex subunit HOOK-interacting protein 1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694361" }, "gene_names": [ { "name": "FHIP1A", "type": "recommended", "evidence": [ { "id": "E1BBC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC1" } ] }, { "name": "FHIP1A", "type": "synonym", "evidence": [ { "id": "XP_002694361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694361" } ] } ], "protein_names": [ { "name": "FHF complex subunit HOOK interacting protein 1A", "type": "synonym", "evidence": [ { "id": "E1BBC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC1/entry#names_and_taxonomy" } ] }, { "name": "FHF complex subunit HOOK-interacting protein 1A", "type": "synonym", "evidence": [ { "id": "XP_002694361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694361" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBC1", "url": "https://www.uniprot.org/uniprotkb/E1BBC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FHIP1A", "url": "https://www.uniprot.org/uniprotkb/E1BBC1", "locus": { "chromosome": "17", "start_pos": 6100573, "end_pos": 6243342, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025263", "url": "https://www.ensembl.org/id/ENSBTAG00000025263" } ] } } ], "crossref": [ { "id": "E1BBC1", "url": "https://alphafold.ebi.ac.uk/entry/E1BBC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025263", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025263", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528939", "url": "https://www.ncbi.nlm.nih.gov/gene/528939", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045669", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045669", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528939", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528939", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RMPSLVQ", "url": "https://omabrowser.org/oma/group/RMPSLVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBC1", "url": "https://www.orthodb.org/?gene=E1BBC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21705", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21705", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21705:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21705:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19311", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19311", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19314", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19314", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694361", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694361", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC1", "url": "https://www.uniprot.org/uniprotkb/E1BBC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMSSVATESKIQRAVSLQGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDEASAVQNYVEHMLFLLIEEQARDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKMEQLKMYEMLITQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEGKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSVVAHHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEGWHCLLRDDWLLLPPLVQFMNSLEFCNAVIQVAHPLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLETFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLILRYLIPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSQCRRDSPGPAEQLLPEASPPSACIVEYGKALDISYLQYLWEAHSNILRCMRDCRVWSALYDGDSPNPEACCLGPPEERAPGATSPVLRLPQQVPGTPMPPLAPGKEKSHTELEWDDSYDTGISSGTGGGSPGPYEDAENASPPVPVDPPKHIQEMKKNAILLFKGAYIEESDFQDDVMVYRLCAEKDAEDVHGSQEHSARPPAQTQVQGAPLNNGPLPGPEPETESEEENGRDDSAVLHGVSRDPARANEPEVTPEATPESAAPSPKAEPSAQPTAAVPEGEDFMAQYDQIIKELGSSTEGLMEQDLALPDALLVTKEPEGEKDESQGGEEEEGKKDPEEEDDDDFDSFIAEAPPAETPPSPFGARDDAAFASHRPARTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDLSDPSTETPTKDPVQDTSRTGSGKNFLDGPPKVLQPFLTNRAKVVGAPPSLPPPVRDTMLAAALFPEFLKELAALAQEHSILCCRILGDPDDACW", "length": 1040, "header": "tr|E1BBC1-1|E1BBC1_BOVIN Isoform 1 of FHF complex subunit HOOK interacting protein 1A OS=Bos taurus OX=9913 GN=FHIP1A PE=3 SV=3 CANONICAL=E1BBC1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD0/entry", "sequence": { "sequence": "MAARRSSKGTPRRGFLFSHPFRLSPRSQQQPLPPDCPPIPTLQLTPAAPSGGFPSLSRVVKILEKHDPLKNTQAKYGSIPPDEASAVQNYVEHMLFLLIEEQARDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKMEQLKMYEMLITQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEGKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSVVAHHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEGWHCLLRDDWLLLPPLVQFMNSLEFCNAVIQVAHPLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLETFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLILRYLIPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSQCRRDSPGPAEQLLPEASPPSACIVEYGKALDISYLQYLWEAHSNILRCMRDCRVWSALYDGDSPNPEACCLGPPEERAPGATSPVLRLPQQVPGTPMPPLAPGKEKSHTELEWDDSYDTGISSGTGGGSPGPYEDAENASPPVPVDPPKHIQEMKKNAILLFKGAYIEESDFQDDVMVYRLCAEKDAEDVHGSQEHSARPPAQTQVQGAPLNNGPLPGPEPETESEEENGRDDSAVLHGVSRDPARANEPEVTPEATPESAAPSPKAEPSAQPTAAVPEGEDFMAQYDQIIKELGSSTEGLMEQDLALPDALLVTKEPEGEKDESQGGEEEEGKKDPEEEDDDDFDSFIAEAPPAETPPSPFGARDDAAFASHRPARTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDLSDPSTETPTKDPVQDTSRTGSGKNFLDGPPKVLQPFLTNRAKVVGAPPSLPPPVRDTMLAAALFPEFLKELAALAQEHSILCCRILGDPDDACW", "length": 1063, "header": "tr|A0A3Q1LRD0-1|E1BBC1_BOVIN Computationally mapped isoform of FHF complex subunit HOOK interacting protein 1A OS=Bos taurus OX=9913 GN=FHIP1A PE=3 SV=1 CANONICAL=E1BBC1-1" }, "locus": { "chromosome": "17", "start_pos": 6210244, "end_pos": 6101577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081700.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081700.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059558.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059558.2" } ] } }, { "isoform_ac": "E1BBC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC1/entry", "sequence": { "sequence": "MMSSVATESKIQRAVSLQGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDEASAVQNYVEHMLFLLIEEQARDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKMEQLKMYEMLITQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEGKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSVVAHHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEGWHCLLRDDWLLLPPLVQFMNSLEFCNAVIQVAHPLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLETFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLILRYLIPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSQCRRDSPGPAEQLLPEASPPSACIVEYGKALDISYLQYLWEAHSNILRCMRDCRVWSALYDGDSPNPEACCLGPPEERAPGATSPVLRLPQQVPGTPMPPLAPGKEKSHTELEWDDSYDTGISSGTGGGSPGPYEDAENASPPVPVDPPKHIQEMKKNAILLFKGAYIEESDFQDDVMVYRLCAEKDAEDVHGSQEHSARPPAQTQVQGAPLNNGPLPGPEPETESEEENGRDDSAVLHGVSRDPARANEPEVTPEATPESAAPSPKAEPSAQPTAAVPEGEDFMAQYDQIIKELGSSTEGLMEQDLALPDALLVTKEPEGEKDESQGGEEEEGKKDPEEEDDDDFDSFIAEAPPAETPPSPFGARDDAAFASHRPARTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDLSDPSTETPTKDPVQDTSRTGSGKNFLDGPPKVLQPFLTNRAKVVGAPPSLPPPVRDTMLAAALFPEFLKELAALAQEHSILCCRILGDPDDACW", "length": 1040, "header": "tr|E1BBC1-1|E1BBC1_BOVIN Isoform 1 of FHF complex subunit HOOK interacting protein 1A OS=Bos taurus OX=9913 GN=FHIP1A PE=3 SV=3 CANONICAL=E1BBC1-1" }, "locus": { "chromosome": "17", "start_pos": 6220375, "end_pos": 6101577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018468.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018468.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018468.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018468.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528939", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528939", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GM32-1", "protein_name": "FHF complex subunit HOOK interacting protein 1A", "gene_name": "Fhip1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMSSVSTESKLQQAVSLKGVDPETCMIVFKNHWAQVVLAILQVVKILEKHDPLKNIQAKYGSIPPDEASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVCENIMEKLFLWSLRREFTDETKLEQLKMYEMLVTQSYQPLLHHKPILKPLMMLLSSCSGTATPAVEGKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVANHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPALVQFMNSLEFCNAVIQVAHPLIRTQLVSYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLVPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCASGITLTLGNQERDYILWSKCMHDGSGPEEQPLPETPCSPSSPPPPPQPAPAACIVEYGKALDISYLQYLWEAHTNILHCMRDCRVWSALYDGDSPDPETFLQSLSEESRENSSHPEARLSQQCIRTSGQTKDKSQSELEWDDSYDTGISSGADVGSPGPYDDVETPAPPAPIDPPKHIQEMKKNAILLFKGSYIEESDFQDDVMVYRLCAEKDAEDTREPQGATTDPPAEAQPKAQPEAQSLPTSNGPLFSPNPEAESKPGRESSDLCQNMFSEAKPESEPGVALDSDSELTVPTFEAEPQSDSPVASTEGEDFIAQYDQIIQELDSGTEGLTEQSVPASEPSLLTHADEGRTECKAEEEEEDDDFDSLMADTPAEEAAPSPFGVGEDTATFTSRHPTRTQGTPFTGPFLSVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDMSDMTPVALTKDPIQEISRPESDKTLTDGPPRVLQPFLGNRAQMTKAPPNLPLPVKNTMLAAALFPEFLKELAALAQEHSILCYKILGDLEDSCC", "length": 1050 }, "evidence": [ { "id": "E1BBC1", "url": "https://omabrowser.org/oma/group/E1BBC1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LUW6-1", "protein_name": "FHF complex subunit HOOK interacting protein 1A", "gene_name": "FHIP1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMTSVATESKLQQAVSLQGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPSDEASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKMEQLKMYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTATPAVEGKLVVLLSQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVAQHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPPLVQFMNSLEFCNAVIQVAHPLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLIPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSKCTQDSPGPMEQRLPETLSPSACIVEAGRALDISYLQYLWEAHTNILRCMRDCRVWSARYDGDSPDPEALGPGPPVPLEERAPRSTSPALSQRPVLRTPGPPLALGKDRSHVELEWDDSYDTGISSGADGGSPGPSEDAENSGPPAPVEPPKHIQEMKKNAILLFKGAYIEEADFQDDVMVYRLCSEKDAEEARSSQEGGARPPTQAQTEVQSPTAHNGPLPGAQPETDSEEERGRDESDALQSVAKEPERDQVPEVVPGPDPELVPHSPQAEHDAHLATTNPEGEDFIAQYDQIIKELDSGTEGSMEQCFSSPDPLLLTKEPEGEQDQRKGDEEEGPREPEEEEEDDDFDSFIAETPAAETQPFPFGARDEATGGSHRPLRTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASMERDFAGLLIQAQQYLLFRVDLSDPSPEAPTKDPVQDASRTASGKNFLDGPPRVLQPFLTHRAKLAGAPPSLPGPVRNTMLAAALFPEFLKELAALAQEHSILCCKVLGDLDDSCC", "length": 1044 }, "evidence": [ { "id": "E1BBC1", "url": "https://omabrowser.org/oma/group/E1BBC1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q05DH4-1", "protein_name": "FHF complex subunit HOOK-interacting protein 1A", "gene_name": "FHIP1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMSSVSTESKLQQAVSLQGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDEASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVSENIMEKLFLWSLRREFTDETKIEQLKMYEMLVTQSHQPLLHHKPILKPLMMLLSSCSGTTTPTVEEKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGSVGQQARDALLFIMSLSAENTMVAHHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEEWHCLLKDDWLLLPSLVQFMNSLEFCNAVIQVAHPLIRNQLVNYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLHQHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLIPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCSSGITLTLGNQERDYILWSKCMHDTSGPVERPFPEAFSESACIVEYGKALDISYLQYLWEAHTNILRCMRDCRVWSALYDGDSPDPEMFLQSLTEEGSVSSACPVFGLPQQLPRKTGPQLAPRKDKSQTELEWDDSYDTGISSGADVGSPGPYDDLEVSGPPAPIDPPKHIQEMKKNALLLFKGSYIEESDFQDDVMVYRLCAEKDSEDMKDSQEEAARPPAEAQAEVQSVPINNGPLLSTQPETDSEEEWNRDNSDPFHSEPKEPKQEREPEAAPESNSELASPAPEAEHSSNLTAAHPESEELIAQYDQIIKELDSGAEGLMEQNYPTPDPLLLTKEEEGKEESKGEKEKEGKKELEDEEDDFDSFIAEMPAVETVPSPFVGRDEAAFASRHPVRTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDMSDMTPAALTKDPIQEASRTGSGKNLLDGPPRVLQPFLTHRTKVAEAPPNLPLPVRNPMLAAALFPEFLKELAALAQEHSILCYKILGDFEDSCC", "length": 1040 }, "evidence": [ { "id": "E1BBC1", "url": "https://omabrowser.org/oma/group/E1BBC1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q505K2-1", "protein_name": "FHF complex subunit HOOK-interacting protein 1A", "gene_name": "Fhip1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMSSVSTESKLQQAVSLKGVDPETCMIVFKNHWAQVVKILEKHDPLKNTQAKYGSIPPDEASAVQNYVEHMLFLLIEEQAKDAAMGPILEFVVCENIMEKLFLWSLRREFTDETKLEQLKMYEMLVTQSYQPLLHHKPILKPLMMLLSSCSGTATPAVEGKLVVLLNQLCSILAKDPSILELFFHTSEDQGAANFLIFSLLIPFIHREGTVGQQARDALLFIMSLSAENSMVANHIVENTYFCPVLATGLSGLYSSLPTKLEEKGEDWHCILKDDWLLLPALVQFMNSLEFCNAVIQVAHPLIRTQLVSYIYNGFLVPVLAPALHKVTVEEVMTTTAYLDLFLRSISEPALLEIFLRFILLHRHENVHILDTLTSRINTPFRLCVVSLALFRTLIGLHCEDVMLQLVLRYLVPCNHMMLSQRWAVKERDCYSVSAAKLLALTPVCCASGITLTLGNQERDYILWSKCMHDGSGSEEQLLPETPCSPSSPSPPPPPAPAACIVEYGKALDISYLQYLWEAHTNILHCMRDCRVWSALYDGDSPDPETFLQSLSEESRENSGHPEARLPQQSVRTSGQTKDKSQSELEWDDSYDTGISSGADVGSPGPDDEVETPAPPAPIDPPKHIQEMKKNAILLFKGSYIEESDFQDDVMVYRLCAEKDTEDTTEPQKDTSEPQGDTLEPLEDTSEQQEDTSEQLEDTSELQEDTAEPQGDTADPTAEAQPKLQPEAQSLPTSNGPLSSPDPETESQPSRESSDLCQNTFSEAKPENEPGVALALDSELIATTFEAEPQSELAVVSTESEDFIAQYDQIIQELDSGTEGLTEQSIPISEPSLLTQQEERREECKEEEDDDFDSLMAATPAVEAGSSPFGVGEDTAFSSRHPVRTQSTPFTGPFISVVLSKLENMLENSLHVNLLLIGIITQLASYPQPLLRSFLLNTNMVFQPSVRSLYQVLASVKNKIEQFASVERDFPGLLIQAQQYLLFRVDMSDMAPAALTKDPIQEISRPESDKTLLDGPPRVLQPFLGNRAKVTRAPPNLPLPVKNTMLAAALFPEFLKELAALAQEHSILCYKILGDFEDSCC", "length": 1081 }, "evidence": [ { "id": "E1BBC1", "url": "https://omabrowser.org/oma/group/E1BBC1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VQK0-1", "protein_name": "FHIP family protein CG3558", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MWLRQSSGGGVASVGHVGPLRQRPIDAATDCDPRACYDSFCKHWQQAFEIIQHSAPPSHDDVLGVVSHLDYMVTLLLVELHHCNKVSLPAAEASGPPAAPCLEFLLSENLLDKLYEWACTTGRYANAVRLEQLKLYELLVSHSRHQLLCHEPFLRPLLKILASSQGEIFPPDLEKRLVILLNQLCVVLMQNVHLLDLFFFSAQTQVQEQILNGNVAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDALLLCMALSQKNSNIGTYIAQYSSICPLLVTGLGGLYSRLPNSIEISSIDWHRITPDDVTEIPELTLFMNALEFCNAVVQVAHEMIKQQLLDFMYQGFIVPVLGPAILQTNIDSQISAMSYLDLILRSITEPGLLRAFVRFLLDTEKFDGERILDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLELLLKFMLPGKHVPISHRHKINKIDPYLNSSEFFLELSPDVMKRARDLARPKSVHEPVVSELTPLPSLPSPVMSKTIGANWNYYGVHTGDSLYANIQAYLFEAHWRIAQCQKDCLKWANSYRYQKWPRHGQGRVHAHALELARQFFSEFGGGPIAANETGEKQLDSLQSIGESSGYESFKWRPADEESEATDTTVATTASEADMDHNSSSLSSVLGASGKRESWRTSNSNRNELILTDLDFSEDLFAQGTVSLGPFLNAIWGKLQTFTSNSLYVNLHLTGLITRLAWYPLPLIHSLLLRSDIAITSDTPSFHQVLRILKQQIDAELPVTEDSLEIIDVARSSLIDREFRLANARKGNEGSPMHHSQQQQMVTNSGQQQGQLRSAYATLSAATPVQATPTSAYDPFKRSDNKRRSISKSITSMFSRKSASTSTAPPNGSSASSGLSQIYAFFTGAASNLVGNNASNDGRGISQAQTSAGTCETSLSTQPPAGASRTGANATSTAASGSNSSIAGSTLTLSAQSNTTTHSASTLHGLDGGPSTGGFNSEPASLDSVASMGIIASTSGTERSRDLALCAVLMDEWLKELAAIAQEQSVVLVTEQGSL", "length": 1041 }, "evidence": [ { "id": "E1BBC1", "url": "https://omabrowser.org/oma/group/E1BBC1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein localization to perinuclear region of cytoplasm", "id": "GO:1905719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905719", "evidence": [ { "database": "UniProtKB", "id": "E1BBC1", "url": "https://www.uniprot.org/uniprotkb/E1BBC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 604, "end_pos": 606 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7U8-1", "uniprot_ac": "E1B7U8", "uniprot_id": "E1B7U8_BOVIN", "mass": { "chemical_mass": 84395.0, "monoisotopic_mass": 84395.0 }, "refseq": { "ac": "NP_001179250", "name": "leucine-rich repeat-containing protein 36", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179250" }, "gene_names": [ { "name": "LRRC36", "type": "recommended", "evidence": [ { "id": "E1B7U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7U8" } ] }, { "name": "LRRC36", "type": "synonym", "evidence": [ { "id": "NP_001179250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179250" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 36", "type": "synonym", "evidence": [ { "id": "E1B7U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7U8/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 36", "type": "synonym", "evidence": [ { "id": "NP_001179250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179250" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7U8", "url": "https://www.uniprot.org/uniprotkb/E1B7U8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC36", "url": "https://www.uniprot.org/uniprotkb/E1B7U8", "locus": { "chromosome": "18", "start_pos": 34997794, "end_pos": 34936751, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001838", "url": "https://www.ensembl.org/id/ENSBTAG00000001838" } ] } } ], "crossref": [ { "id": "E1B7U8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7U8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001838", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001838", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512403", "url": "https://www.ncbi.nlm.nih.gov/gene/512403", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512403", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVVPNDM", "url": "https://omabrowser.org/oma/group/HVVPNDM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSK0", "url": "https://www.orthodb.org/?gene=A0A3Q1LSK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7U8", "url": "https://www.orthodb.org/?gene=E1B7U8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23311:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23311:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179250", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7U8", "url": "https://www.uniprot.org/uniprotkb/E1B7U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7U8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7U8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEQWELDEEGIRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKSLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVYMLQTLEKLDDRAVRESERKAAKLHFSQLGNSENFLLEVEKSSREKTVKNCVTNESTASKVSTDSDNRIETDSNKGLFIPFPNREIKDSLTSTSATQGSVIPDQKLDPFLLGTQMQEVARREMPSENNQEDEIRRYSPHQMTVRSPEKMAKEGYRISFLDNKSSGSSPEKDLIPKPDTYQLTHDASLGKRLDVGDSSQIHPYQLPSDVGLENYDSHYSQNLSLHGSIGKRPQRNKNYREYSTKPSNNMKATTSHSCGDLLTSLSNPDSSTGRLLKLSSDLYAATHFNSDPALVVNVEQQLATSLSDLTQAHGSFPNNSILGDSLRTLLLPTGTSENRENLTKRSLSPSRRGFRRKENILATLNTKHGFRDATGSEPLSSDLGSLHGLPGNHSPPVSARTSHVATVLRQLLELVDKHWNGSGSLLLNKKFLGPARDLLLTLVVPAPSQQWCRSHPEDTSKAFHRREMELKETGQLVPNDMEGLKQKLVRVLEENLILSEKVQRLEEGATTSIVSGHPSHTYDDLLRKNQQLNMQVSCLNQELAQLKKLEETVTLLHESQRSLVVTNEYLLQQLNKEQKGYSGKALLPPEKSHHLGRSSPFGKSTLSSSSPVAHDMGQYLIQTVSDSVPEPSLWS", "length": 754, "header": "tr|E1B7U8-1|E1B7U8_BOVIN Isoform 1 of Leucine rich repeat containing 36 OS=Bos taurus OX=9913 GN=LRRC36 PE=4 SV=1 CANONICAL=E1B7U8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSK0/entry", "sequence": { "sequence": "MLRPRFLPPDDRAVRESERKAAKLHFSQLGNSENFLLEVEKSSREKTVKNCVTNESTASKVSTDSDNRIETDSNKGLFIPFPNREIKDSLTSTSATQGSVIPDQKLDPFLLGTQMQEVARREMPSENNQEDEIRRYSPHQMTVRSPEKMAKEGYRISFLDNKSSGSSPEKDLIPKPDTYQLTHDASLGKRLDVGDSSQIHPYQLPSDVGLENYDSHYSQNLSLHGSIGKRPQRNKNYREYSTKPSNNMKATTSHSCGDLLTSLSNPDSSTGRLLKLSSDLYAATHFNSDPALVVNVEQQLATSLSDLTQAHGSFPNNSILGDSLRTLLLPTGTSENRENLTKRSLSPSRRGFRRKENILATLNTKHGFRDATGSEEGLKQKLVRVLEENLILSEKVQRLEEGATTSIVSGHPSHTYDDLLRKNQQLNMQVSCLNQELAQLKKLEETVTLLHESQRSLVVTNEYLLQQLNKEQKGYSGKALLPPEKSHHLGRSSPFGKSTLSSSSPVAHDMGQYLIQTVSDSVPEPSLWS", "length": 529, "header": "tr|A0A3Q1LSK0-1|E1B7U8_BOVIN Computationally mapped isoform of Leucine rich repeat containing 36 OS=Bos taurus OX=9913 GN=LRRC36 PE=4 SV=2 CANONICAL=E1B7U8-1" }, "locus": { "chromosome": "18", "start_pos": 34997704, "end_pos": 34952421, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078012.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078012.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059997.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059997.2" } ] } }, { "isoform_ac": "E1B7U8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7U8/entry", "sequence": { "sequence": "MAEQWELDEEGIRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKSLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVYMLQTLEKLDDRAVRESERKAAKLHFSQLGNSENFLLEVEKSSREKTVKNCVTNESTASKVSTDSDNRIETDSNKGLFIPFPNREIKDSLTSTSATQGSVIPDQKLDPFLLGTQMQEVARREMPSENNQEDEIRRYSPHQMTVRSPEKMAKEGYRISFLDNKSSGSSPEKDLIPKPDTYQLTHDASLGKRLDVGDSSQIHPYQLPSDVGLENYDSHYSQNLSLHGSIGKRPQRNKNYREYSTKPSNNMKATTSHSCGDLLTSLSNPDSSTGRLLKLSSDLYAATHFNSDPALVVNVEQQLATSLSDLTQAHGSFPNNSILGDSLRTLLLPTGTSENRENLTKRSLSPSRRGFRRKENILATLNTKHGFRDATGSEPLSSDLGSLHGLPGNHSPPVSARTSHVATVLRQLLELVDKHWNGSGSLLLNKKFLGPARDLLLTLVVPAPSQQWCRSHPEDTSKAFHRREMELKETGQLVPNDMEGLKQKLVRVLEENLILSEKVQRLEEGATTSIVSGHPSHTYDDLLRKNQQLNMQVSCLNQELAQLKKLEETVTLLHESQRSLVVTNEYLLQQLNKEQKGYSGKALLPPEKSHHLGRSSPFGKSTLSSSSPVAHDMGQYLIQTVSDSVPEPSLWS", "length": 754, "header": "tr|E1B7U8-1|E1B7U8_BOVIN Isoform 1 of Leucine rich repeat containing 36 OS=Bos taurus OX=9913 GN=LRRC36 PE=4 SV=1 CANONICAL=E1B7U8-1" }, "locus": { "chromosome": "18", "start_pos": 34997704, "end_pos": 34936769, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002402.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002402.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002402.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002402.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512403", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512403", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GH65-1", "protein_name": "Leucine rich repeat containing 36", "gene_name": "Lrrc36", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEQWDLDEECLRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVYTLQMLEKLDDRAVRDSERRAAKLHFSQLGSSENFLLEVEKSSREKTMKNCVTDEGPASHVSSEVDTRMETDSNKGLFISFPNREIKDSLASICATQGSGTPAQKLDVFPLETQMQEATRRETSDLHQEDGLELRHYSPHQGTVRSPEKMTRDGYRVSFLDTKSSGSSPVKDLIPKPDAYPCTHDASLGKRLDVGDSNQILPCQLPSGVCLDHYDNHYSQTLCLHGSLVKRPQKGKYYREYSTKPSNDKKAASSLSCGDLLTSLSNPDCSTGRPLKLSSDLYATTRFNSDHALLANVEQQLSSLGDFAPAPGSFPSNPALGNSLRTLLLPPGTPENREIPTKRSLSPSRRGFKRKDNILANLNLKRGFQDATGSEVQPFSSDLGSLHGLSGNRSPPISARTPHVATVLRQLLELVDKHWNGSGSLLLNKKFLGPARDLLLSLVVPAPPQQWHRSLLDDKTGRALHWRETELKEAGQLVPSDVESLKQKLVKVLEENLILSEKIQQLEGAAATSVVSGHPSHTHDDLLHKNQQLTIQVACLNQELTQLKRLEETVALLHESQRSLVVTNEYLLQQLNKEQKGYSGKSLLPPEKTHPLGRLSPFGKSTLSSSSPTVHNTGQYLIQSVSEADPEPSLWS", "length": 757 }, "evidence": [ { "id": "E1B7U8", "url": "https://omabrowser.org/oma/group/E1B7U8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q1X8D7-1", "protein_name": "Leucine-rich repeat-containing protein 36", "gene_name": "LRRC36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEQWELDEEGIRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVYTLQTLEKLDDRTVREGERKAAKLHFSQLGNSENFLLEVEKSSREKTMKNCVTGESSASKVSANVDSRIEMDSNKGLFIPFPNREIKDSLSTSATQGNGTRDQKLDTFPLGTQTQEVARREMPSDNHQEDEFRHYSPRQSTVRSPEKMTREGYQVSFLDNKSSGSSPEKELIPKPDTFHLTHDASLSKCLDVGDSSQIHPYQLPSDVGLENYDSCYSQTLSLHGSLGKRPQRSKNYQEYSIKPSNDIKTTASHSCGDLLTSLSNPDSSTGRLLKLSSDLYATTHFNSDPAVLVNVEQQLSTSLDDLTPAHGSVPNNAVLGNRTTPLRTLLLSPGTSEHRKIFTKRSLSPSKRGFKWKDNILANLNLKHGFQDATGSEPLSSDLGSLHGLAGNHSPPISARTPHVATVLRQLLELVDKHWNGSGSLLLNKKFLGPARDLLLSLVVPAPSQPRCCSHPEDTMKAFCRRELELKEAAQLVPNDMESLKQKLVRVLEENLILSEKIQQLEEGAAISIVSGQQSHTYDDLLHKNQQLTMQVACLNQELAQLKKLEKTVAILHESQRSLVVTNEYLLQQLNKEPKGYSGKALLPPEKGHHLGRSSPFGKSTLSSSSPVAHETGQYLIQSVLDAAPEPGL", "length": 754 }, "evidence": [ { "id": "E1B7U8", "url": "https://omabrowser.org/oma/group/E1B7U8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3V0M2-1", "protein_name": "Leucine-rich repeat-containing protein 36", "gene_name": "Lrrc36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEQWDLDEECLRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVYTLQTLEKLDDRAVRDSERRAAKLHFSQLGNSENFLLEVEKSSREKTMKNCVTDEGPASHVSPEVDARMETDANKGLFIPFPNREIKDSLTSICAAQGSGTPAQKLDVFPLGTQMQEATRRETSDLHQEDELRLYPPPQSTVRSPEKMTRDGYRVSFLDTKSSGSSPEKDLIPKPDAYPCTHDASLGKRLDVGDSNQILPCQLPSEVCLDHYGNQYSQTLCLHGSLVKRAQKGKNYREHSIKPSQDKKATTSHPCGDLLTSLSNPDSSTGRLLRLSSDLYATTHFNSDPALLANVEQQLSSLRDFTPAPGSFPSSPALGNSLRTLLLPPGTPENREIPTKRSLSPSRRGFKRKDGILANPSLKRGFQDATGSEAQPLSSDLGSLHGLSGNHSPPISARTPHVATVLRQLLELVDKHWNGSGSLLLDKKFLGPARDLLLSLVVPAPSQQWRRSKLDDKAGKALCWRETELKEAGLLVPNDVESLKQKLVKVLEENLVLSEKIQQLEGTAATSIVSGHPSHTHDELLRKNQQLTIQVACLTQELTQLKRLEETVALLHESQRSLVVTNEYLLQQLHKEQKGYSGKSLLPPEKSHPLGRSSPFGKSTLSSSSPMVHDTGQYLIQSVSEADPEPSLWS", "length": 755 }, "evidence": [ { "id": "E1B7U8", "url": "https://omabrowser.org/oma/group/E1B7U8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7U8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 754, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7U8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7U8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 175, "end_pos": 177 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 511, "end_pos": 513 }, { "start_pos": 539, "end_pos": 541 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA11-1", "uniprot_ac": "E1BA11", "uniprot_id": "E1BA11_BOVIN", "mass": { "chemical_mass": 130580.0, "monoisotopic_mass": 130580.0 }, "refseq": {}, "gene_names": [ { "name": "FAM184A", "type": "recommended", "evidence": [ { "id": "E1BA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA11" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 184 member A", "type": "synonym", "evidence": [ { "id": "E1BA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA11/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA11", "url": "https://www.uniprot.org/uniprotkb/E1BA11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM184A", "url": "https://www.uniprot.org/uniprotkb/E1BA11", "locus": { "chromosome": "9", "start_pos": 32077696, "end_pos": 31932666, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015467", "url": "https://www.ensembl.org/id/ENSBTAG00000015467" } ] } } ], "crossref": [ { "id": "E1BA11", "url": "https://alphafold.ebi.ac.uk/entry/E1BA11", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR039478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MCKKVAQ", "url": "https://omabrowser.org/oma/group/MCKKVAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR18870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18870:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18870:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15665", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15665", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LTB7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4I1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4I1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4I1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA55-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN13", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN13-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NX15", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NX15-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA11", "url": "https://www.uniprot.org/uniprotkb/E1BA11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA11-1", "url": "https://www.uniprot.org/uniprotkb/E1BA11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATPGMSWQQHYYGGSAAKFVPSPAAGQQAGHCMDYSQDMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLRYH", "length": 1116, "header": "tr|E1BA11-1|E1BA11_BOVIN Isoform 1 of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=3 CANONICAL=E1BA11-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB7/entry", "sequence": { "sequence": "MDYSQDMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1107, "header": "tr|A0A3Q1LTB7-1|E1BA11_BOVIN Computationally mapped isoform of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=2 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32076692, "end_pos": 31953403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074516.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074516.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060303.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060303.2" } ] } }, { "isoform_ac": "A0A3Q1M4I1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4I1/entry", "sequence": { "sequence": "MRWLDGITDSVGVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1099, "header": "tr|A0A3Q1M4I1-1|E1BA11_BOVIN Computationally mapped isoform of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=2 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32076692, "end_pos": 32000608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086650.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086650.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068493.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068493.2" } ] } }, { "isoform_ac": "A0A3Q1MA55-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA55/entry", "sequence": { "sequence": "MGHGSLGVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1094, "header": "tr|A0A3Q1MA55-1|E1BA11_BOVIN Computationally mapped isoform of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=2 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32076692, "end_pos": 31932829, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066389.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066389.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067478.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067478.2" } ] } }, { "isoform_ac": "A0A3Q1MN13-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN13/entry", "sequence": { "sequence": "MATPGMSWQQHYYGGSAAKFVPSPAAGQQAGHCMDYSQDMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1084, "header": "tr|A0A3Q1MN13-1|E1BA11_BOVIN Computationally mapped isoform of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=3 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32076692, "end_pos": 31953304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079537.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079537.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073249.3", "url": "https://www.ensembl.org/id/ENSBTAP00000073249.3" } ] } }, { "isoform_ac": "A0AAA9SFA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA8/entry", "sequence": { "sequence": "MATPGMSWQQHYYGGSAAKFVPSPAAGQQAGHCMDYSQDMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1056, "header": "tr|A0AAA9SFA8-1|E1BA11_BOVIN Computationally mapped isoform of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=1 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32076692, "end_pos": 31953304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105880.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105880.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082294.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082294.1" } ] } }, { "isoform_ac": "A0ABI0NX15-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX15/entry", "sequence": { "sequence": "MELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLRYH", "length": 268, "header": "tr|A0ABI0NX15-1|A0ABI0NX15_BOVIN Computationally mapped isoform of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=1 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32075893, "end_pos": 32060223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143512.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143512.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104151.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104151.1" } ] } }, { "isoform_ac": "E1BA11-1", "url": "https://www.uniprot.org/uniprotkb/E1BA11/entry", "sequence": { "sequence": "MATPGMSWQQHYYGGSAAKFVPSPAAGQQAGHCMDYSQDMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLRRKIQVLEASLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKCQQDHSASVNKGQEKAEELHRMEVEALNKTLEELRLERKKLVEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQIALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKNLQSRLEGEVAQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEELENKLHSANQEIGRLQEMVSKSEQGLGSAEGLIASLQDSQERLQNELDLTKGRLKETKDALLNVESKLEQERRQHEETLAAMKEEEKLQVDRMAHDLEMKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALESHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNQQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENINALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEVNAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLMEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLMKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLRYH", "length": 1116, "header": "tr|E1BA11-1|E1BA11_BOVIN Isoform 1 of Family with sequence similarity 184 member A OS=Bos taurus OX=9913 GN=FAM184A PE=4 SV=3 CANONICAL=E1BA11-1" }, "locus": { "chromosome": "9", "start_pos": 32075893, "end_pos": 31953304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020593.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020593.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020593.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020593.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1037, "start_aa": "Thr", "end_pos": 1037, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1037", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3, "start_aa": "Thr", "end_pos": 3, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PFG2-1", "protein_name": "Family with sequence similarity 184 member A", "gene_name": "FAM184A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATPGMSWQQQHGYGGGSAPGAGKFSSGSAPSGLGAEHSPDLHFKMSKKIAQLTKVIYALNTKNDEHEAAIQALKDAHEEEIQQILAETREKILQYKSKVAEEMDLKRKIQVLEESLEDHKKMKHQALTEFEAYKDRVEDMQLCAEAQHVQRVVTMSREVEEIRKKFEERLRSFIQLQVQYEKDKRSALEDLRAAHRLEIQELLKTQQNQNATLSKGQEKLEELHRLELEDLNNKVEELRLERKKLIEDYEGKLSKAQSFYEHELDSLKRSQLFTAESLHACKEKEVELRKEFQNQESILRKNLGKLKTELQMVQDEAASLREKCQKLQVALSTAENNVQVLQKQLDDVKEEEMSLLSKHKEVESELAAARERLQQQATDLVLKASHIGMLQATQMTQEVTIRDLESEKSRLKEKLSQLEEERNLLQSKTQSLDERQRQQILALEKKVNEARETQREYYEKELVKLQARLEGEAAQLKEAHSKTLEELAWKHHTAIEAAHSNANKDKKKLQMELEQQFEKEKLHLEDDKNQLRQQLENLREELTTKLTSANQEVCRLQDLVRKSEQGLGTAEGHISSLQEAQEILQKELELTRARLRETTDSLYNVEGELDQERQQHEVMIAAMREEEKFKVDRMARDLEIKWTENLRQECNKLREELRLQHEEDKKAAMTQLLQLKEREKNAARDGWQKKVEDLLDQISLLKQNLEMQLSQSQSSLQQLQAQFSQERQRLTQEIQELEEEHQQRHKSLQEAHILAFQNMEETKEQEQKELEERLQQKHSEELQALKETHKQAMEGFKLEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDQLRHNHQQELLAAKMELERSIELGRRQEKEFLCRISDLQDELRHRDHHIAELDKEILHLHDNISALTKELEFKGKEVLRIRSESNQQIRMHEQDLSKKHEKELDVLTADHIREKQSMLADFNKTQELLKEINSALQVSLEEMEEKYKNRESRPEDLQLISELKDLIAERDQLIKKLIEDKKFYQLELVNRETNYNKVFNASPNVGVINPLVKQKKKNDKSTNRFVSVPNLSALESSGVGNGHPNRLDPIPNSPIHDIEFNSSKPLPQPIPPKEPKTFLSPPQTDASPVASPDPQRQEWLARYFTF", "length": 1141 }, "evidence": [ { "id": "E1BA11", "url": "https://omabrowser.org/oma/group/E1BA11/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A480JNE4-1", "protein_name": "Family with sequence similarity 184 member A", "gene_name": "FAM184A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATPGMSWQQHYYGGSAAGAAKFPPSPAAAHQAGHSMDYSQDLHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSRVTEELDLKRKIQVLEASLEDHVKMKQAALAEFEAYKHRIEDMQLCAEAQHVQRIVTMSREVEEIRRKFEERLRSFGQLQVQFEKDKRLALEDLRTAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVEALNQTLEELRLERKKLIEDYEGKLHKAQSFYEHELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLRDKCQKLQLALVTAENNVQVLQKQLDDAKEGEMALLSRHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSKANERLSQLEEERAFLQSKTQSLDEEQKQQILELEKKVNEAKKTQQEYYEMELKDLQNRLEGEMAQLNEAHSKTLEELAWKHHMAIEAVHSNVIRDKKKLQMELEEQYKKEKLNLEEDKNQLQQELENLKEEMEDKLNSANQEIGRLQDIVSKSEQGLGSAEGLIASLQDSQDRLQNELELTKGRLRETKDALLNVEGELEQERQQHEEILAAMKEEEKLRVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKEREKNAAKDSWQKKVEDLLNQISLLKQNLEMQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHMCRITDLQDEVRHREHHISDLDKEVQHLHENISALTKELEFKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMIAELKAMLTERDQVIKKLIEDNKFYQLELINRETNFNKVFNSSPTVGVINPLTKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKEPKTFLSPPQSEASPAASPDPQRQEWFARYFTF", "length": 1143 }, "evidence": [ { "id": "E1BA11", "url": "https://omabrowser.org/oma/group/E1BA11/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZS46-1", "protein_name": "Family with sequence similarity 184, member A", "gene_name": "Fam184a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATPGMSWQHHYYGGSSSGPAKFTTSPAAAQLAGHNMDYSQDMHLKMSKKIAQLTKVIYALNTKNDEHDSAIQALKDAHEEEIQQILAETREKILLYKSRVTEELDLKRKIQVLEASLEDHVKMKQEALKEFEAYKRRVEDMQLCAEAQHVQRIVTMSREVEEIRKKFEERLRSFGQLQVQFENDKQSALEELRTTHRLEVQELLRSQEDHSASMNLGQEKAEELHRREVEALNNTLEELRLEKKELIEEYEGKLSKAQLFYERELDNLKRSQLFTAESLQASRDKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEASSLLDKCQKLQMALATAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQEQASDLVRKASHIGMLQATQMTQEVTIKDLESEKSRAHERLCQLEKERAFLQSRTQSLDEEQKQQELEMEKKVNEVKRTQQEYYEMELKNLQTRLEGEVAQLNETHGKTLEELAWKHHMAIEAVHSNASRDKIKLQTELEEQHKKEKLSLEEDKNQLQLELENLKQALGDKLTSANQEIDRLQDLVRKSEQGLGSAEGLIASLQDSQERLQSELDLTKGRLKETKDALLNVEAELQQERHEHEQTLATMKEEEKLRVDRMAHDLEIKWTENLRQECSKLRQELKLQHEEDKKCAMSQLLQLKEREKTAARDSWQKKVEDLLNQRHSLGEALHKSINNISLLKQNLELQLCQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALETHLQQKHSAELQSLKDAHRESMEGFRVEMEQELQTLRFELEDEGKAMLASLRSELNHQHATSIDLLRHSHHQELAAAKMELERSIDISRRQSKEHMCRISDLQDELRHREHHITDLDKEVQHLHESISTLTKELELKGKEILRIRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEDMEEKYLMRESRPEDLQMIAELKSLLTERDQVIKKLIQKKKNDKSPANRFVSVPNLSALESGGMGNGHPTRLEPIPNSPAHDVEFNSNKPLPQPLPPKEPKTFLSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1122 }, "evidence": [ { "id": "E1BA11", "url": "https://omabrowser.org/oma/group/E1BA11/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9PW83-1", "protein_name": "Family with sequence similarity 184, member A", "gene_name": "Fam184a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATPGMSWQHHYYGSSTSGPAKFATSPAAAQLAGHNMDYSQDMHLKMSKKIAQLTKVIYALNTRNDEHDAAIQALKDAHEEEIQQILAETREKILLYKSKVTEELDLRRKIQVLEASLEDHMKMKQEALTEFEAYKRRVEDMQLCAEAQHVQRIVTMSREVEEIRKKFEERLRSFGQLQVQFENDKQAALEDLRTTHRLEVQELLKSQQNHSSSVKLGQEKAEGLHRMEVEALNNTVKELRLEKKQLIEEYEGKLSKAQVFYERELDNLKRSQLFTAESLQASRDKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEASSLLDKCQKLQMALATAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQEQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRANERLCQLEEERAFLQSRTQSLDEEQKQQVLELEKKVNEAKRTQQEYYEMELKNLQNRLEGEVAQLNEAHGKTLEELARKHHMAIEAVHSNASRDKIKLQTELEEQYKKEKLSLEEDKNQLQLELESLKQALGDKLTSANQEIGRLQDLVRKSEQGLGSAEGLISSLQDSQERLQSELDLTKGRLKETKDALLNVEAELQQERHEHEQTLATMKEEEKLRVDRMAHDLEIKWTENLRQECSKLRQELRLQHEEDKKSAMSQLLQLKEREKNAARDSWQKKVEDLLNQISLLKQNLELQLCQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALETHLQQKHSAELQSLKDAHRESMEGFRVEMEQELQTLRFELEDEGKAMLASLRSELNHQHAASIDLLRHSHHQELAAAKMELERSIDISRRQSKEHMCRISDLQEELRHREHHITDLDKEVQHLHENINTLTKELELKGKEILRVRSESNQQMRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEDMEEKYLMRESRPEDIQMIAELKSLITERDQVIKKLIEDNKFYQLELVNRETNFNKIFNTSPTVGVINPLAKQKKKNDKSAANRFVSVPNLSALESSGMGNGHPTRLEPIPNSPAHDVEFNSNKPLPQPLPPKEPKTFLSPPQSEASPVASPDPQRQEWFARYFTF", "length": 1143 }, "evidence": [ { "id": "E1BA11", "url": "https://omabrowser.org/oma/group/E1BA11/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5SPS1-1", "protein_name": "Protein FAM184A isoform X1", "gene_name": "fam184ab", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATGAGWQHYYNPAGSASTGKYNSTSTSTSTSTSFPSGLTLEYTQDLHLKMSKKIAQLTKVIYALNTKNDEHEAAIQTLKEAHEEEVQQILSETREKIMQYKSKISDEMDLKRRIQSLEESMELHERMKRQALDEFETYRQRVEDMQLCTEAQHTQRVVSMSREVEEMRRSFEEKLRSFAQLQSQFEQEKRQALEELRSGHRQEVQELLRSHQSQNANYSKDQEKLGQLHKAEVDSLNERVEELKQDKKRLVEEYEAKLNKAQAFYERELEAMKRTQQMTAENLLAWKKTEAELRKEFQAQEAALQKTLGKLRSELQRVQDEARESREKSHKLQASLMTAENNIKELHKQLEEVTKDAEIVEIRQREGECELEASRDRVQQQATEILLKASQIGSLQATQMTHEAVIRDLESEKSRLKDKVLRLEEERGALQNKCQTLDDRQRQQIVTLEKSLREEKQIYEKELMNLRAKYEDDTAHFKESHSRALEELSRKHRASLENIQSLSEKEKNRLLSDMEDQFNKERTSLEEQKRILREELDSLREELTAKLNMANNEVSRLQELVKQGEQTLGSSEGHISNLKDAQKKLLEELDATRARLRETSNLLTALQGEMETQKQQHDAKLISIKEEEKLKMDKMALELELKWTETLRQECKKLREELREDHEEDKRSALTQLAQNKDQELCSARESWQRKVEDLLEQISLLKQSLEMQLSQSQHSLQQLQAQFSQEREHLGQQLEEMEMEHQHRQQRLQEAHCCAIQDMQEARKHDLKALEERLRQQHHMELQTLREAHRQNIETLKQQSEQELQTLRFELEDEGKAMLASLRSELNHLHASAIEHMRQTHQQETAAAKQELENALEQSRVQERELLSRISDLQEEVSRRKKHIADLDHEIHTLNENISTLTKELELKGKEVLKIRSEANQQIRAHEQDLCKKHEREMAELNALHHRETQNMLSDFNKAQELLKDKISALQILLEGTEDKFRNRESRPEDLQTIAELKDMVAEREALVKKLVDDKKFYQLELVNRETSFNKIFNANPNVGVINPLVKQKRKNDKSATRFSSSANLRANVEASGTGSGQPQPNRLEPLPNSPIHQLEPNASKPLSLPTPLTEPKKVTSPPEGEESALTSPDPQRQEWFAQYFSF", "length": 1145 }, "evidence": [ { "id": "E1BA11", "url": "https://omabrowser.org/oma/group/E1BA11/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8NB25-1", "protein_name": "Protein FAM184A", "gene_name": "FAM184A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF", "length": 1140 }, "evidence": [ { "id": "E1BA11", "url": "https://omabrowser.org/oma/group/E1BA11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "E1BA11", "url": "https://www.uniprot.org/uniprotkb/E1BA11" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "E1BA11", "url": "https://www.uniprot.org/uniprotkb/E1BA11" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "E1BA11", "url": "https://www.uniprot.org/uniprotkb/E1BA11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1033, "end_pos": 1035, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1064, "end_pos": 1066, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1095, "end_pos": 1097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 956, "end_pos": 958, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA11" }, { "id": "PF15665", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15665" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein FAM184A/B N-terminal", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 264, "start_aa": "Val", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 3, 1037 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1033, "end_pos": 1035 }, { "start_pos": 1064, "end_pos": 1066 }, { "start_pos": 1095, "end_pos": 1097 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 956, "end_pos": 958 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCR9-1", "uniprot_ac": "E1BCR9", "uniprot_id": "E1BCR9_BOVIN", "mass": { "chemical_mass": 63366.0, "monoisotopic_mass": 63366.0 }, "refseq": { "ac": "XP_002698391", "name": "pantothenate kinase 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698391" }, "gene_names": [ { "name": "PANK1", "type": "recommended", "evidence": [ { "id": "E1BCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ] }, { "name": "PANK1", "type": "synonym", "evidence": [ { "id": "XP_002698391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698391" } ] } ], "protein_names": [ { "name": "pantothenate kinase", "type": "recommended", "evidence": [ { "id": "E1BCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR9/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.33", "type": "synonym", "evidence": [ { "id": "E1BCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR9/entry#names_and_taxonomy" } ] }, { "name": "pantothenate kinase 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698391" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PANK1", "url": "https://www.uniprot.org/uniprotkb/E1BCR9", "locus": { "chromosome": "26", "start_pos": 11247532, "end_pos": 11345780, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010442", "url": "https://www.ensembl.org/id/ENSBTAG00000010442" } ] } } ], "crossref": [ { "id": "E1BCR9", "url": "https://alphafold.ebi.ac.uk/entry/E1BCR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010442", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010442", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd24135", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd24135", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535887", "url": "https://www.ncbi.nlm.nih.gov/gene/535887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535887", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535887", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NEDYEIH", "url": "https://omabrowser.org/oma/group/NEDYEIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LU79", "url": "https://www.orthodb.org/?gene=A0A3Q1LU79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCR9", "url": "https://www.orthodb.org/?gene=E1BCR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12280", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12280", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12280:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12280:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03630", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03630", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196783", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196783", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002698391", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698391", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16373", "url": "https://www.rhea-db.org/rhea/16373", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LU79", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU79-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCR9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKLGGGGQDWACSVAGTGLGGEEASFEVARLGQRGKAGSGGPGWGCAGIPNSAPGAGMLQAGAGGPALEGQGVEEVGTPEGGGEERPARHPPAPALRLLNRKPQGGSGEIKTSENDLQRGRLSRGPRAAPPASGMGDHGGQPERSAPHAPGTPAGVGAAAVNGLLHNGFHPSRLCSRGPPGGGDAAPPRLPLQPELQPQPPPPQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHKFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRTIADLQLHKLDELDCLIQGLLYVDSIGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMPDDQ", "length": 591, "header": "tr|E1BCR9-1|E1BCR9_BOVIN Isoform 1 of pantothenate kinase OS=Bos taurus OX=9913 GN=PANK1 PE=3 SV=2 CANONICAL=E1BCR9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU79-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU79/entry", "sequence": { "sequence": "MKLINGKKQTFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHKFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRTIADLQLHKLDELDCLIQGLLYVDSIGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMPDDQ", "length": 373, "header": "tr|A0A3Q1LU79-1|E1BCR9_BOVIN Computationally mapped isoform of pantothenate kinase OS=Bos taurus OX=9913 GN=PANK1 PE=3 SV=1 CANONICAL=E1BCR9-1" }, "locus": { "chromosome": "26", "start_pos": 11301957, "end_pos": 11248536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069419.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069419.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060893.1" } ] } }, { "isoform_ac": "A0AAA9TJP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJP9/entry", "sequence": { "sequence": "MKLINGKKQTFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHKFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRTIADLQLHKLDELDCLIQGLLYVDSIGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMPDDQ", "length": 314, "header": "tr|A0AAA9TJP9-1|E1BCR9_BOVIN Computationally mapped isoform of pantothenate kinase OS=Bos taurus OX=9913 GN=PANK1 PE=3 SV=1 CANONICAL=E1BCR9-1" }, "locus": { "chromosome": "26", "start_pos": 11301957, "end_pos": 11248536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102527.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102527.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097373.1" } ] } }, { "isoform_ac": "E1BCR9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR9/entry", "sequence": { "sequence": "MLKLGGGGQDWACSVAGTGLGGEEASFEVARLGQRGKAGSGGPGWGCAGIPNSAPGAGMLQAGAGGPALEGQGVEEVGTPEGGGEERPARHPPAPALRLLNRKPQGGSGEIKTSENDLQRGRLSRGPRAAPPASGMGDHGGQPERSAPHAPGTPAGVGAAAVNGLLHNGFHPSRLCSRGPPGGGDAAPPRLPLQPELQPQPPPPQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHKFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRTIADLQLHKLDELDCLIQGLLYVDSIGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMPDDQ", "length": 591, "header": "tr|E1BCR9-1|E1BCR9_BOVIN Isoform 1 of pantothenate kinase OS=Bos taurus OX=9913 GN=PANK1 PE=3 SV=2 CANONICAL=E1BCR9-1" }, "locus": { "chromosome": "26", "start_pos": 11303502, "end_pos": 11248536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050296.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050296.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047024.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047024.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:535887", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535887", "resource": "KEGG Pathway" }, { "id": "R-BTA-196783", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196783", "resource": "Reactome", "description": "Coenzyme A biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "pmid": "" }, { "name": "pantothenate kinase activity", "id": "GO:0004594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004594", "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "coenzyme A biosynthetic process", "id": "GO:0015937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015937", "evidence": [ { "database": "UniProtKB", "id": "E1BCR9", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16373", "name": "", "equation": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DA5-1", "E1BCR9-1", "F1MX42-1" ], "evidence": [ { "id": "16373", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16373" } ] }, { "id": "R-BTA-199203", "name": "PANK1/3 phosphorylate PanK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-196820" ], "output_participant_list": [], "enzyme_list": [ "Q08DA5-1", "E1BCR9-1" ], "evidence": [ { "id": "R-BTA-199203", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-199203" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-196820", "participant_name": "PanK [cytosol]", "crossref": [ { "id": "29032", "database": "ChEBI", "url": "" }, { "id": "C00864", "database": "KEGG Gene", "url": "" }, { "id": "PANTOTHENATE", "database": "AraCyc", "url": "" }, { "id": "C00864", "database": "COMPOUND", "url": "" }, { "id": "Vitamin_B5", "database": "Wikipedia", "url": "" }, { "id": "167945", "database": "PubChem Compound", "url": "" }, { "id": "79-83-4", "database": "CAS", "url": "" }, { "id": "ZINC000005356910", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1BCR9", "gene_name": "PANK1", "activity": [ { "ec_number": "2.7.1.33", "activity": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+).", "evidence": [ { "id": "E1BCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ] }, { "ec_number": "2.7.1.33", "activity": "", "evidence": [ { "id": "E1BCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR9" } ] } ] }, { "uniprot_ac": "F1MX42", "gene_name": "PANK2", "activity": [ { "ec_number": "2.7.1.33", "activity": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+).", "evidence": [ { "id": "F1MX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX42" } ] }, { "ec_number": "2.7.1.33", "activity": "", "evidence": [ { "id": "F1MX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX42" } ] } ] }, { "uniprot_ac": "Q08DA5", "gene_name": "PANK3", "activity": [ { "ec_number": "2.7.1.33", "activity": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+).", "evidence": [ { "id": "Q08DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA5" } ] }, { "ec_number": "2.7.1.33", "activity": "", "evidence": [ { "id": "Q08DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCR9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 591, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCR9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCR9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.33", "ec_name": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+).", "evidence": [ { "id": "2.7.1.33", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.33" }, { "id": "2.7.1.33", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.33" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 290, "end_pos": 292 }, { "start_pos": 321, "end_pos": 323 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9X1-1", "uniprot_ac": "E1B9X1", "uniprot_id": "E1B9X1_BOVIN", "mass": { "chemical_mass": 199854.0, "monoisotopic_mass": 199854.0 }, "refseq": { "ac": "XP_024836579", "name": "retinoic acid-induced protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836579" }, "gene_names": [ { "name": "RAI1", "type": "recommended", "evidence": [ { "id": "E1B9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X1" } ] }, { "name": "RAI1", "type": "synonym", "evidence": [ { "id": "XP_024836579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836579" } ] } ], "protein_names": [ { "name": "Retinoic acid induced 1", "type": "synonym", "evidence": [ { "id": "E1B9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X1/entry#names_and_taxonomy" } ] }, { "name": "retinoic acid-induced protein 1", "type": "synonym", "evidence": [ { "id": "XP_024836579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836579" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9X1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAI1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1", "locus": { "chromosome": "19", "start_pos": 34648144, "end_pos": 34732552, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004768", "url": "https://www.ensembl.org/id/ENSBTAG00000004768" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004768", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004768", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528972", "url": "https://www.ncbi.nlm.nih.gov/gene/528972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528972", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528972", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B9X1", "url": "https://www.orthodb.org/?gene=E1B9X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14955", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14955", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14955:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14955:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836579", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9X1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9X1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSFRERCGFHGKQQTYQQTSQETSRLENYRQPSQAGLSCDRQRLLTKDYYGPQPFPGYEGGGGTPATARAGKGLSSPQAPPGRPAFAGYTVQDGSPYPGRYSGEEGLQAWGGPQPPPPQPQPLPGGVGKYDENLMKKTVVPPSRQYPEQGAQLPFRTHALHVQQQLPQPPPSLAYPKLQRQKPQSDLASPLPFSQGSHFPQQSQSFPTSSTYSSSGQAGGQGAHSYKSCTAPSAQPHDRPLTANASLAPGQRVPNLHAYQSSRLSYDPQKQQQQQQALQSRHHAQESLHYQNLAKYQHYGQQGPGYCQPDATVRTPEQYYQTFSPSSGHSPARSVGRSPSYSSTPSPLMPNLENFPYNQQPLGPGAFPAGLTDHSHFMPLLNPSPTDAASSVDTQAANCKALQKDKLPESLLSDLSLHSLTALTSQVENISNTVQQLLLSKAAGPQKKGLKSLVARTPEQHKSQHCSPEGSGYSAEPAGTPLSEPLSSTPQSTHAEPPEADYLSGSEDPLERSFLYCSQARGSPARVHGGSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSSLPLDSFSKLVAGERDCPRLLLSALAQEDLASEILGLQEAISEKADKAWAEAPGLAKDTGKPPFSLENHSACLDPVAKGAWPRPGEPEALPEALQLDKGSSAKDFSPGLFEDPSVGFTTPDPKKTAGPLSFGAKPTLGAAASDPTVAFDCFPDTTSAGSADGTHPFAWPEENLGDACPRWGLHPGELTKGLEQGGKATDSASQDGTREASACLGFQEEVPPGEKAAVPRDSQQETAGGVKEEAGGLLQCPEVSKADRWLDDSRHCCSAADFGDLPLLPAPGRKEDLEAEEYSSLCELLGSPEQRPGLQDALSPKAPLLCGKEEVEEVLDPKAGWGSPCPLSGDSVILLGPTVGAESKVQSWFESSLSHMKPEEEGPEGVLAPGDSAAVTPEASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPALPKDLLLPESCTGPPQGQMEGAGAPGRGISEGLPRMCTRSFTALSEPRTPGPPGLPTTPAPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSLDAPGKDQRSMILRSRSRAQEAFHSKRRRPSESRLPNCRAAKKLLANNHLPTTFKVAGSPQKEGRVGQRARVPKPGASGKLSDRPLHTLKRKSAFMAPVPTKKRNLVLRSGGLGGDVKEEGAEGSPTLFKRMTSPKKAKPTKGNGEPTAKPPPLETPDTGLKLASRASFQGAMKTKVLPPRKGRGLKLEAIVQKITSPSLKKFACRAPGAPPGNPVSPSLPEKERGLKSAGGSLLGAEEGLLNVSPGQKFPAALGAEPLCRNPTNRSLKGKLVNSKKLSLTDGFKTEAFTSPEALLPGGTALAPKKRSRKGRTGALGLPKGSLEKRPHLGPALLLTPRDRANGTQGGSEDSSGVGGKKPKTEELGLAAQPPEGRPCQPQTRAQKQPGHANYSSYSKRKRLTRGRAKSTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRADSRTPAFSPFVRVEKQGAFTTVCTVVNSPGEEPQPQRKPSSSSSSCSLDAAGASLATLPGGSIPPPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRLEGTCEEASLPLERTLKGFECPAAASSAATTTTGKPPRPDGPADPAKQGSLRTSARGLSRRLQSCYCCDGRGDGSEEAAPADKSRKHECSKEPPAEPGGDTQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVALDMTCSSCQEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCPKHKRLPL", "length": 1885, "header": "tr|E1B9X1-1|E1B9X1_BOVIN Isoform 1 of Retinoic acid induced 1 OS=Bos taurus OX=9913 GN=RAI1 PE=4 SV=2 CANONICAL=E1B9X1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT0/entry", "sequence": { "sequence": "MQSFRERCGFHGKQQTYQQTSQETSRLENYRQPSQAGLSCDRQRLLTKDYYGPQPFPGYEGGGGTPATARAGKGLSSPQAPPGRPAFAGYTVQDGSPYPGRYSGEEGLQAWGGPQPPPPQPQPLPGGVGKYDENLMKKTVVPPSRQYPEQGAQLPFRTHALHVQQQLPQPPPSLAYPKLQRQKPQSDLASPLPFSQGSHFPQQSQSFPTSSTYSSSGQAGGQGAHSYKSCTAPSAQPHDRPLTANASLAPGQRVPNLHAYQSSRLSYDPQKQQQQQQALQSRHHAQESLHYQNLAKYQHYGQQGPGYCQPDATVRTPEQYYQTFSPSSGHSPARSVGRSPSYSSTPSPLMPNLENFPYNQQPLGPGAFPAGLTDHSHFMPLLNPSPTDAASSVDTQAANCKALQKDKLPESLLSDLSLHSLTALTSQVENISNTVQQLLLSKAAGPQKKGLKSLVARTPEQHKSQHCSPEGSGYSAEPAGTPLSEPLSSTPQSTHAEPPEADYLSGSEDPLERSFLYCSQARGSPARVHGGSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSSLPLDSFSKLVAGERDCPRLLLSALAQEDLASEILGLQEAISEKADKAWAEAPGLAKDTGKPPFSLENHSACLDPVAKGAWPRPGEPEALPEALQLDKGSSAKDFSPGLFEDPSVGFTTPDPKKTAGPLSFGAKPTLGAAASDPTVAFDCFPDTTSAGSADGTHPFAWPEENLGDACPRWGLHPGELTKGLEQGGKATDSASQDGTREASACLGFQEEVPPGEKAAVPRDSQQETAGGVKEEAGGLLQCPEVSKADRWLDDSRHCCSAADFGDLPLLPAPGRKEDLEAEEYSSLCELLGSPEQRPGLQDALSPKAPLLCGKEEVEEVLDPKAGWGSPCPLSGDSVILLGPTVGAESKVQSWFESSLSHMKPEEEGPEGVLAPGDSAAVTPEASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPALPKDLLLPESCTGPPQGQMEGAGAPGRGISEGLPRMCTRSFTALSEPRTPGPPGLPTTPAPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSLDAPGKDQRSMILRSRSRAQEAFHSKRRRPSESRLPNCRAAKKLLANNHLPTTFKVAGSPQKEGRVGQRARVPKPGASGKLSDRPLHTLKRKSAFMAPVPTKKRNLVLRSGGLGGDVKEEGAEGSPTLFKRMTSPKKAKPTKGNGEPTAKPPPLETPDTGLKLASRASFQGAMKTKVLPPRKGRGLKLEAIVQKITSPSLKKFACRAPGAPPGNPVSPSLPEKERGLKSAGGSLLGAEEGLLNVSPGQKFPAALGAEPLCRNPTNRSLKGKLVNSKKLSLTDGFKTEAFTSPEALLPGGTALAPKKRSRKGRTGALGLPKGSLEKRPHLGPALLLTPRDRANGTQGGSEDSSGVGGKKPKTEELGLAAQPPEGRPCQPQTRAQKQPGHANYSSYSKRKRLTRGRAKSTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRADSRTPAFSPFVRVEKQGAFTTVCTVVNSPGEEPQPQRKPSSSSSSCSLDAAGASLATLPGGSIPPPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRLEGTCEEASLPLERTLKGFECPAAASSAATTTTGKPPRPDGPADPAKQGSLRTSARGLSRRLQSCYCCDGRGDGSEEAAPADKSRKHECSKEPPAEPGGDTQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVALDMVRGQSRRVGPRVLQAGRQAFFPVLRCGPDRPSHK", "length": 1867, "header": "tr|A0A3Q1LXT0-1|E1B9X1_BOVIN Computationally mapped isoform of Retinoic acid induced 1 OS=Bos taurus OX=9913 GN=RAI1 PE=4 SV=1 CANONICAL=E1B9X1-1" }, "locus": { "chromosome": "19", "start_pos": 34650990, "end_pos": 34648144, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077709.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077709.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060344.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060344.2" } ] } }, { "isoform_ac": "E1B9X1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1/entry", "sequence": { "sequence": "MQSFRERCGFHGKQQTYQQTSQETSRLENYRQPSQAGLSCDRQRLLTKDYYGPQPFPGYEGGGGTPATARAGKGLSSPQAPPGRPAFAGYTVQDGSPYPGRYSGEEGLQAWGGPQPPPPQPQPLPGGVGKYDENLMKKTVVPPSRQYPEQGAQLPFRTHALHVQQQLPQPPPSLAYPKLQRQKPQSDLASPLPFSQGSHFPQQSQSFPTSSTYSSSGQAGGQGAHSYKSCTAPSAQPHDRPLTANASLAPGQRVPNLHAYQSSRLSYDPQKQQQQQQALQSRHHAQESLHYQNLAKYQHYGQQGPGYCQPDATVRTPEQYYQTFSPSSGHSPARSVGRSPSYSSTPSPLMPNLENFPYNQQPLGPGAFPAGLTDHSHFMPLLNPSPTDAASSVDTQAANCKALQKDKLPESLLSDLSLHSLTALTSQVENISNTVQQLLLSKAAGPQKKGLKSLVARTPEQHKSQHCSPEGSGYSAEPAGTPLSEPLSSTPQSTHAEPPEADYLSGSEDPLERSFLYCSQARGSPARVHGGSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSSLPLDSFSKLVAGERDCPRLLLSALAQEDLASEILGLQEAISEKADKAWAEAPGLAKDTGKPPFSLENHSACLDPVAKGAWPRPGEPEALPEALQLDKGSSAKDFSPGLFEDPSVGFTTPDPKKTAGPLSFGAKPTLGAAASDPTVAFDCFPDTTSAGSADGTHPFAWPEENLGDACPRWGLHPGELTKGLEQGGKATDSASQDGTREASACLGFQEEVPPGEKAAVPRDSQQETAGGVKEEAGGLLQCPEVSKADRWLDDSRHCCSAADFGDLPLLPAPGRKEDLEAEEYSSLCELLGSPEQRPGLQDALSPKAPLLCGKEEVEEVLDPKAGWGSPCPLSGDSVILLGPTVGAESKVQSWFESSLSHMKPEEEGPEGVLAPGDSAAVTPEASLAQKPNKPAVPEAPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRAPALPKDLLLPESCTGPPQGQMEGAGAPGRGISEGLPRMCTRSFTALSEPRTPGPPGLPTTPAPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSLDAPGKDQRSMILRSRSRAQEAFHSKRRRPSESRLPNCRAAKKLLANNHLPTTFKVAGSPQKEGRVGQRARVPKPGASGKLSDRPLHTLKRKSAFMAPVPTKKRNLVLRSGGLGGDVKEEGAEGSPTLFKRMTSPKKAKPTKGNGEPTAKPPPLETPDTGLKLASRASFQGAMKTKVLPPRKGRGLKLEAIVQKITSPSLKKFACRAPGAPPGNPVSPSLPEKERGLKSAGGSLLGAEEGLLNVSPGQKFPAALGAEPLCRNPTNRSLKGKLVNSKKLSLTDGFKTEAFTSPEALLPGGTALAPKKRSRKGRTGALGLPKGSLEKRPHLGPALLLTPRDRANGTQGGSEDSSGVGGKKPKTEELGLAAQPPEGRPCQPQTRAQKQPGHANYSSYSKRKRLTRGRAKSTTSSPCKGRAKRRRQQQVLPLDPAEPEIRLKYISSCKRLRADSRTPAFSPFVRVEKQGAFTTVCTVVNSPGEEPQPQRKPSSSSSSCSLDAAGASLATLPGGSIPPPRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCLPKKKPKLKEKVRLEGTCEEASLPLERTLKGFECPAAASSAATTTTGKPPRPDGPADPAKQGSLRTSARGLSRRLQSCYCCDGRGDGSEEAAPADKSRKHECSKEPPAEPGGDTQEHWVHEACAVWTGGVYLVAGKLFGLQEAMKVALDMTCSSCQEAGATIGCCHKGCLHTYHYPCASDAGCIFIEENFSLKCPKHKRLPL", "length": 1885, "header": "tr|E1B9X1-1|E1B9X1_BOVIN Isoform 1 of Retinoic acid induced 1 OS=Bos taurus OX=9913 GN=RAI1 PE=4 SV=2 CANONICAL=E1B9X1-1" }, "locus": { "chromosome": "19", "start_pos": 34662047, "end_pos": 34650995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006264.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006264.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006264.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006264.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 345, "start_aa": "Thr", "end_pos": 345, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr345", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 387, "start_aa": "Thr", "end_pos": 387, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr387", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 65, "start_aa": "Thr", "end_pos": 65, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr65", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 914, "start_aa": "Thr", "end_pos": 914, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr914", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:528972", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528972", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B9X1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B9X1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "E1B9X1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1" } ], "pmid": "" }, { "name": "circadian regulation of gene expression", "id": "GO:0032922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032922", "evidence": [ { "database": "UniProtKB", "id": "E1B9X1", "url": "https://www.uniprot.org/uniprotkb/E1B9X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1361, "end_pos": 1363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1383, "end_pos": 1385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1460, "end_pos": 1462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1508, "end_pos": 1510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1872, "end_pos": 1874, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 65, 345, 387, 914 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1361, "end_pos": 1363 }, { "start_pos": 1383, "end_pos": 1385 }, { "start_pos": 1460, "end_pos": 1462 }, { "start_pos": 1508, "end_pos": 1510 }, { "start_pos": 1872, "end_pos": 1874 }, { "start_pos": 245, "end_pos": 247 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 631, "end_pos": 633 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B944-1", "uniprot_ac": "E1B944", "uniprot_id": "E1B944_BOVIN", "mass": { "chemical_mass": 117398.0, "monoisotopic_mass": 117398.0 }, "refseq": {}, "gene_names": [ { "name": "IQCH", "type": "recommended", "evidence": [ { "id": "E1B944", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B944" } ] } ], "protein_names": [ { "name": "IQ motif containing H", "type": "synonym", "evidence": [ { "id": "E1B944", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B944/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B944", "url": "https://www.uniprot.org/uniprotkb/E1B944" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IQCH", "url": "https://www.uniprot.org/uniprotkb/E1B944", "locus": { "chromosome": "10", "start_pos": 14332278, "end_pos": 14212548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013638", "url": "https://www.ensembl.org/id/ENSBTAG00000013638" } ] } } ], "crossref": [ { "id": "E1B944", "url": "https://alphafold.ebi.ac.uk/entry/E1B944", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013638", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013638", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B944", "url": "https://www.orthodb.org/?gene=E1B944", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14465:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14465:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZ30", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1W1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1W1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1W1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1W1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B944", "url": "https://www.uniprot.org/uniprotkb/E1B944", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B944-1", "url": "https://www.uniprot.org/uniprotkb/E1B944-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQEKENQDPVGSILIQVHEDLYELREKLTKFPLEEKGGALDIQNLETAIKRTEMGLKIHIEKYLNVVHQHVLTTPIDYNLYSSHASKWLFPAVLDQKTFIFPLESEGKLWRPQKEHSSFPHAFPRIKVKAQKLIKGSTISSLTVLPASHRTDPYFTPVPVLQADANKGVLSMIERGLIPATARITFQNPPIVPRAATLHHFDEGRKILATAPFAAPQRTESIPEEMKTVSLKRQRSKWKGRKSRGYHDKKAMKATAPSKTQKSPWDYDFFIYNGVVDKTAPDFLAFKEHFSLSWGSIFSLLEHIEKFLKDYAIPEVKIKANSLVTLLPEFELKNKLTRYDLLSVLENPVDIQMMLNLPGQRYKGQDGKTEAAMKIQATWKCYKARKYFLSYRRQKWASGVIAIAWLLHCHKTRLRKLLKESRERHLENFRIRAKHLAANWNRIRTSRRTIIHIPSLGYSQPVRQNIADFNTEQNTQLGRLCDILDAKVSVIYICSHRMNDELLLYYNKILSLQAAVKSGNLEDRSDLRDRFKIITPEAINIFTKQHMCLATHLMYSPKAIKRIKNLIQGKEAYIVSGLLHRDDLAVADMLNIPILGSEPELAHFYSTKSGSKRVFENANVPVPPGIYNIYSHQKIIEQVSQLVIDHLEIQRWLFKADYEFGGNGTAFCDIPSHLKCYNWILKESQRYSREDWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAYPPSESITNVTVDMLIEPNGEIRLLSTGDQFHAEGPFISSGTTVPQTSVDPQVLSSLCLQIGKACKMKNVIGHFSIDLMTFIDPSTMEQQVWATGLNLSYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFAPKKDKKMNNLNVHKGPSQATSRYAVMSTQLRHESLSLFFHYVFLHMCKAHGIGYNIEDRQGTIFILFENLKRDRLGMLTIGEDLQGVLMTFARNLFIIHQEISAPNMQGETNFKAAIDDLEAILGVTEENKLRFEENLQSKHKTLSKPDK", "length": 1026, "header": "tr|E1B944-1|E1B944_BOVIN Isoform 1 of IQ motif containing H OS=Bos taurus OX=9913 GN=IQCH PE=4 SV=5 CANONICAL=E1B944-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ30/entry", "sequence": { "sequence": "MAQEKENQDPVGSILIQVHEDLYELREKLTKFPLEEKGGALDIQNLETAIKRTEMGLKIHIEKYLNVVHQHVLTTPIDYNLYSSHASKWLFPAVLDQKTFIFPLESEGKLWRPQKEHSSFPHAFPRIKGKTGLNIKIMQDPESIHHRAAVNATYGISLPYINQRKAS", "length": 167, "header": "tr|A0A3Q1LZ30-1|E1B944_BOVIN Computationally mapped isoform of IQ motif containing H OS=Bos taurus OX=9913 GN=IQCH PE=4 SV=2 CANONICAL=E1B944-1" }, "locus": { "chromosome": "10", "start_pos": 14140688, "end_pos": 14103373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070827.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070827.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062876.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062876.2" } ] } }, { "isoform_ac": "A0ABI0P1W1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1W1/entry", "sequence": { "sequence": "MAQEKENQDPVGSILIQVHEDLYELREKLTKFPLEEKGGALDIQNLETAIKRTEMGLKIHIEKYLNVVHQHVLTTPIDYNLYSSHASKWLFPAVLDQKTFIFPLESEGKLWRPQKEHSSFPHAFPRIKGKTGLNIKIMQDPESIHHRAAVNATYGISLPYINQRKASVKAQKLIKGSTISSLTVLPASHRTDPYFTPVPVLQADANKGVLSMIERGLIPATARITFQNPPIVPRAATLHHFDEGRKILATAPFAAPQRTESIPEEMKTVSLKRQRSKWKGRKSRGYHDKKAMKATAPSKTQKSPWDYDFFIYNGVVDKTAPDFLAFKEHFSLSWGSIFSLLEHIEKFLKDYAIPEVKIKANSLVTLLPEFELKNKLTRYDLLSVLENPVDIQMMLNLPGQRYKGQDGKTEAAMKIQATWKCYKARKYFLSYRRQKWASGVIAIAWLLHCHKTRLRKLLKESRERHLENFRIRAKHLAANWNRIRTSRRTIIHIPSLGYSQPVRQNIADFNTEQNTQLGRLCDILDAKVSVIYICSHRMNDELLLYYNKILSLQAAVKSGNLEDRSDLRDRFKIITPEAINIFTIIEQVSQLVIDHLEIQRWLFKADYEFGGNGTAFCDIPSHLKCYNWILKESQRYSREDWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAYPPSESITNVTVDMLIEPNGEIRLLSTGDQFHAEGPFISSGTTVPQTSVDPQVLSSLCLQIGKACKMKNVIGHFSIDLMTFIDPSTMEQQVWATGLNLSYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFAPKKDKKMNNLNVHKGPSQATSRYAVMSTQLRHESLSLFFHYVFLHMCKAHGIGYNIEDRQGTIFILFENLKRDRLGMLTIGEDLQGVLMTFARNLFIIHQEISAPNMQGETNFKAAIDDLEAILGVTEENKLRFEENLQSKH", "length": 966, "header": "tr|A0ABI0P1W1-1|A0ABI0P1W1_BOVIN Computationally mapped isoform of IQ motif containing H OS=Bos taurus OX=9913 GN=IQCH PE=4 SV=1 CANONICAL=E1B944-1" }, "locus": { "chromosome": "10", "start_pos": 14332249, "end_pos": 14103373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150744.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150744.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106697.1" } ] } }, { "isoform_ac": "E1B944-1", "url": "https://www.uniprot.org/uniprotkb/E1B944/entry", "sequence": { "sequence": "MAQEKENQDPVGSILIQVHEDLYELREKLTKFPLEEKGGALDIQNLETAIKRTEMGLKIHIEKYLNVVHQHVLTTPIDYNLYSSHASKWLFPAVLDQKTFIFPLESEGKLWRPQKEHSSFPHAFPRIKVKAQKLIKGSTISSLTVLPASHRTDPYFTPVPVLQADANKGVLSMIERGLIPATARITFQNPPIVPRAATLHHFDEGRKILATAPFAAPQRTESIPEEMKTVSLKRQRSKWKGRKSRGYHDKKAMKATAPSKTQKSPWDYDFFIYNGVVDKTAPDFLAFKEHFSLSWGSIFSLLEHIEKFLKDYAIPEVKIKANSLVTLLPEFELKNKLTRYDLLSVLENPVDIQMMLNLPGQRYKGQDGKTEAAMKIQATWKCYKARKYFLSYRRQKWASGVIAIAWLLHCHKTRLRKLLKESRERHLENFRIRAKHLAANWNRIRTSRRTIIHIPSLGYSQPVRQNIADFNTEQNTQLGRLCDILDAKVSVIYICSHRMNDELLLYYNKILSLQAAVKSGNLEDRSDLRDRFKIITPEAINIFTKQHMCLATHLMYSPKAIKRIKNLIQGKEAYIVSGLLHRDDLAVADMLNIPILGSEPELAHFYSTKSGSKRVFENANVPVPPGIYNIYSHQKIIEQVSQLVIDHLEIQRWLFKADYEFGGNGTAFCDIPSHLKCYNWILKESQRYSREDWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAYPPSESITNVTVDMLIEPNGEIRLLSTGDQFHAEGPFISSGTTVPQTSVDPQVLSSLCLQIGKACKMKNVIGHFSIDLMTFIDPSTMEQQVWATGLNLSYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFAPKKDKKMNNLNVHKGPSQATSRYAVMSTQLRHESLSLFFHYVFLHMCKAHGIGYNIEDRQGTIFILFENLKRDRLGMLTIGEDLQGVLMTFARNLFIIHQEISAPNMQGETNFKAAIDDLEAILGVTEENKLRFEENLQSKHKTLSKPDK", "length": 1026, "header": "tr|E1B944-1|E1B944_BOVIN Isoform 1 of IQ motif containing H OS=Bos taurus OX=9913 GN=IQCH PE=4 SV=5 CANONICAL=E1B944-1" }, "locus": { "chromosome": "10", "start_pos": 14332275, "end_pos": 14103373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018126.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018126.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018126.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018126.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1B944", "url": "https://www.uniprot.org/uniprotkb/E1B944" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 754, "end_pos": 756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B944-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1026, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B944-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B944" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B944", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B944" }, { "id": "PF24923", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IQCH-like ATP-grasp", "eco_id": "ECO_0000259", "start_pos": 600, "end_pos": 866, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 664, "end_pos": 666 }, { "start_pos": 754, "end_pos": 756 }, { "start_pos": 842, "end_pos": 844 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC55-1", "uniprot_ac": "E1BC55", "uniprot_id": "E1BC55_BOVIN", "mass": { "chemical_mass": 193889.0, "monoisotopic_mass": 193889.0 }, "refseq": { "ac": "XP_015331050", "name": "uncharacterized protein KIAA1671 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331050" }, "gene_names": [ { "name": "KIAA1671", "type": "recommended", "evidence": [ { "id": "E1BC55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC55" } ] }, { "name": "KIAA1671", "type": "synonym", "evidence": [ { "id": "XP_015331050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331050" } ] } ], "protein_names": [ { "name": "KIAA1671", "type": "synonym", "evidence": [ { "id": "E1BC55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC55/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein KIAA1671 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015331050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331050" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC55", "url": "https://www.uniprot.org/uniprotkb/E1BC55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA1671", "url": "https://www.uniprot.org/uniprotkb/E1BC55", "locus": { "chromosome": "17", "start_pos": 65282650, "end_pos": 65153148, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044022", "url": "https://www.ensembl.org/id/ENSBTAG00000044022" } ] } } ], "crossref": [ { "id": "ENSBTAG00000044022", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044022", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533883", "url": "https://www.ncbi.nlm.nih.gov/gene/533883", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533883", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ADQSGHC", "url": "https://omabrowser.org/oma/group/ADQSGHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC55", "url": "https://www.orthodb.org/?gene=E1BC55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22042", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22042", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22042:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22042:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015331050", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331050", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFH5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFH5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKC0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKC0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC55", "url": "https://www.uniprot.org/uniprotkb/E1BC55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC55-1", "url": "https://www.uniprot.org/uniprotkb/E1BC55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRVEVGSISSLTGVPGLGELSKEEALTRTYFRQAGDAPGPPSTLLLEGKSPLRSPVRLLPLPRLAPKPFSKEKAADVTPLWPSLARPSPAGGLSQDVASGRLNEKMPGLAGQEAGSGDRPRNVSLFPKAAISQPMPNPVIFESNKAGPALGKGACEANAGMSQGPASAPRPEVAAKPAPPARKPVGSLPRPASLPQDSRTVATPEDTGPKEPLSKASSVEDAGGTAPEPPRPRPKRRPVSAIFTESIQTPKPGPSGVAAVGKLPPTPPEKTWVRRPRPLSVDLTARFESREALARKVADEATAGPTAQQRGPERPDPEPRVDRECLVKAEAPPHDPDSDFLQVAQKIQERKERLLLKQGEMGSLRTAGGPARVTPTSAQGLGEEKAKLDREPEKAAKDPQSPLPRPGKGQDMAEVRSREAAGETRVGGEQTPRGGVKNRIGLFGEEGASALAAGFESPPATPESPAIPPEPEKAGVSVQERIKGWATESSEAKPELRRRVVQTRPLSADLTKLFSSAASSNEVRYEKCLELSGELPREPREKPKDRHGVEGTSVTRSPWKPGLPREKPRQTERKDSFDRVPGGARGESAVGARSPSEGTPDDDGSFQTVWATVFENHVEKHTITAPSGRSPWATTPADLANVSEPRSRLLGPRSSFPQTTALKREWLEDPDLERGGGTAFSSGEPRQHRVSSLLGRHPGGEKGSHHPFLKLPESAPAPERVEPRYDVVHAVGERAHSEAVLTAPEEKALTLRSSRSRPPPSQEVTHAMTPADPKCRPEGQVGSVQRAGLIWEARGTREVSGPKPEFHREPKDTHGGSCPSPRWTGGVAVSWHKAAVGLSEGRGTEPSPEAASARTTLEAQHPGTEGAGIQPGERAPPRGAPPEPLPRARDEADDSRVQLQADVLGQTGPLAMAGSQEPEARRRRVSPGDQRLDRWRRRTLPHDVKFDEFSLLPPEHSSRAEPRGDHLSPTAPGALGKPQLLPGREGTGQGSPGTSLDWVLPAAKQGSPVEPKATFFAVTYQIPDTQKAKNVVRPGPENWTEPSRKAAPPLSPLSYTPTSVPLNREELLETVGGKNRALGREREHTSFPKPTEHPASLGDRILGSPGERISDADAVWVRRGPEGGGGFQNGWKDSGNKTSPGGAPQTPPAFRSPPKASELLVRRKTEAVSETFPGKAKAGYRSSVLDIDALMAEYQRPPAGSPREAQEWMAGSPAELRGSDPERPGPQDEADQRRRSLKERPEAEAPQRQASFAETSPGSTPGSGKYLAETPGAATHKVSSPLWGAPHSAPPEKNPGASSGPAAGPRKKGSGIPEDEKKTFVSKHHSAKCQHPSAESKPATAWVDPGGGASVQPKSSPADQRKGTPRKPPGRGEESGVVPWADHLRDLGRSPLDVKRAYSEKGPPLKIREGLSIMQEARERRQEQPKGRPSLPRESAEARDTKTGLCRQESGNRDSQKVSPRDLGRERALPDNEPPLRQVSPATVGPRRSHSFCKDRRSGPFVDQLKQCFSRRTPEAKDTDTLVQETDSQYGTWPDQRQSGESLAPESPSPDSSAASAWKQPPSSRLSSLSSQTEVTSAGDQHDCSREQRSTSVDRSSTDLESTDGMEGPPPPDACPAKKVDDFPFIDQTSVLDSSALKTRVQLSKRSRRRAPTAHSLRRSRTSEPDGRSAWEEEADSAWMFRDSTEEKSPRKEESDEEERTPRAERTPVSRPQRMPVFPGVDPAALKAQLYKRPDSPNETPGWAPQPKTPKSPFQPGVLGSRVLPSSMEKDERSEEPSPQWLKELKSKKRQSLYENQA", "length": 1800, "header": "tr|E1BC55-1|E1BC55_BOVIN Isoform 1 of KIAA1671 OS=Bos taurus OX=9913 GN=KIAA1671 PE=4 SV=3 CANONICAL=E1BC55-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT0/entry", "sequence": { "sequence": "MDYLGDKLTVAQSHVTQWMGTVRRSFQEALNLVTSTVGPERAGGEPSGRTPFKRTSSFRHLASRSRESFRRFSARSQQRFSSLRKRQPDSEPPDLDQLKQCFSRRTPEAKDTDTLVQETDSQYGTWPDQRQSGESLAPESPSPDSSAASAWKQPPSSRLSSLSSQTEVTSAGDQHDCSREQRSTSVDRSSTDLESTDGMEGPPPPDACPAKKVDDFPFIDQTSVLDSSALKTRVQLSKRSRRRAPTAHSLRRSRTSEPDGRSAWEEEADSAWMFRDSTEEKSPRKEESDEEERTPRAERTPVSRPQRMPVFPGVDPAALKAQLYKRPDSPNETPGWAPQPKTPKSPFQPGVLGSRVLPSSMEKDERSEEPSPQWLKELKSKKRQSLYENQA", "length": 391, "header": "tr|A0A3Q1LZT0-1|E1BC55_BOVIN Computationally mapped isoform of KIAA1671 OS=Bos taurus OX=9913 GN=KIAA1671 PE=4 SV=1 CANONICAL=E1BC55-1" }, "locus": { "chromosome": "17", "start_pos": 65282643, "end_pos": 65223250, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069434.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069434.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062853.1" } ] } }, { "isoform_ac": "A0A3Q1MFH5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH5/entry", "sequence": { "sequence": "MATRVEVGSISSLTGVPGLGELSKEEALTRTYFRQAGDAPGPPSTLLLEGKSPLRSPVRLLPLPRLAPKPFSKEKAADVTPLWPSLARPSPAGGLSQDVASGRLNEKMPGLAGQEAGSGDRPRNVSLFPKAAISQPMPNPVIFESNKAGPALGKGACEANAGMSQGPASAPRPEVAAKPAPPARKPVGSLPRPASLPQDSRTVATPEDTGPKEPLSKASSVEDAGGTAPEPPRPRPKRRPVSAIFTESIQTPKPGPSGVAAVGKLPPTPPEKTWVRRPRPLSVDLTARFESREALARKVADEATAGPTAQQRGPERPDPEPRVDRECLVKAEAPPHDPDSDFLQVAQKIQERKERLLLKQGEMGSLRTAGGPARVTPTSAQGLGEEKAKLDREPEKAAKDPQSPLPRPGKGQDMAEVRSREAAGETRVGGEQTPRGGVKNRIGLFGEEGASALAAGFESPPATPESPAIPPEPEKAGVSVQERIKGWATESSEAKPELRRRVVQTRPLSADLTKLFSSAASSNEVRYEKCLELSGELPREPREKPKDRHGVEGTSVTRSPWKPGLPREKPRQTERKDSFDRVPGGARGESAVGARSPSEGTPDDDGSFQTVWATVFENHVEKHTITAPSGRSPWATTPADLANVSEPRSRLLGPRSSFPQTTALKREWLEDPDLERGGGTAFSSGEPRQHRVSSLLGRHPGGEKGSHHPFLKLPESAPAPERVEPRYDVVHAVGERAHSEAVLTAPEEKALTLRSSRSRPPPSQEVTHAMTPADPKCRPEGQVGSVQRAGLIWEARGTREVSGPKPEFHREPKDTHGGSCPSPRWTGGVAVSWHKAAVGLSEGRGTEPSPEAASARTTLEAQHPGTEGAGIQPGERAPPRGAPPEPLPRARDEADDSRVQLQADVLGQTGPLAMAGSQEPEARRRRVSPGDQRLDRWRRRTLPHDVKFDEFSLLPPEHSSRAEPRGDHLSPTAPGALGKPQLLPGREGTGQGSPGTSLDWVLPAAKQGSPVEPKATFFAVTYQIPDTQKAKNVVRPGPENWTEPSRKAAPPLSPLSYTPTSVPLNREELLETVGGKNRALGREREHTSFPKPTEHPASLGDRILGSPGERISDADAVWVRRGPEGGGGFQNGWKDSGNKTSPGGAPQTPPAFRSPPKASELLVRRKTEAVSETFPGKAKAGYRSSVLDIDALMAEYQRPPAGSPREAQEWMAGSPAELRGSDPERPGPQDEADQRRRSLKERPEAEAPQRQASFAETSPGSTPGSGKYLAETPGAATHKVSSPLWGAPHSAPPEKNPGASSGPAAGPRKKGSGIPEDEKKTFVSKHHSAKCQHPSAESKPATAWVDPGGGASVQPKSSPADQRKGTPRKPPGRGEESGVVPWADHLRDLGRSPLDVKRAYSEKGPPLKIREGLSIMQEARERRQEQPKGRPSLPRESAEARDTKTGLCRQESGNRDSQKDQLKQCFSRRTPEAKDTDTLVQETDSQYGTWPDQRQSGESLAPESPSPDSSAASAWKQPPSSRLSSLSSQTEVTSAGDQHDCSREQRSTSVDRSSTDLESTDGMEGPPPPDACPAKKVDDFPFIDQTSVLDSSALKTRVQLSKRSRRRAPTAHSLRRSRTSEPDGRSAWEEEADSAWMFRDSTEEKSPRKEESDEEERTPRAERTPVSRPQRMPVFPGVDPAALKAQLYKRPDSPNETPGWAPQPKTPKSPFQPGVLGSRVLPSSMEKDERSEEPSPQWLKELKSKKRQSLYENQA", "length": 1755, "header": "tr|A0A3Q1MFH5-1|E1BC55_BOVIN Computationally mapped isoform of KIAA1671 OS=Bos taurus OX=9913 GN=KIAA1671 PE=4 SV=1 CANONICAL=E1BC55-1" }, "locus": { "chromosome": "17", "start_pos": 65282643, "end_pos": 65155160, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071852.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071852.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069882.1" } ] } }, { "isoform_ac": "A0ABI0NKC0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKC0/entry", "sequence": { "sequence": "MEYYYCPSLLKLLQYLWDQLKQCFSRRTPEAKDTDTLVQETDSQYGTWPDQRQSGESLAPESPSPDSSAASAWKQPPSSRLSSLSSQTEVTSAGDQHDCSREQRSTSVDRSSTDLESTDGMEGPPPPDACPAKKVDDFPFIDQTSVLDSSALKTRVQLSKRSRRRAPTAHSLRRSRTSEPDGRSAWEEEADSAWMFRDSTEEKSPRKEESDEEERTPRAERTPVSRPQRMPVFPGVDPAALKAQLYKRPDSPNETPGWAPQPKTPKSPFQPGVLGSRVLPSSMEKDERSEEPSPQWLKELKSKKRQSLYENQA", "length": 313, "header": "tr|A0ABI0NKC0-1|A0ABI0NKC0_BOVIN Computationally mapped isoform of KIAA1671 OS=Bos taurus OX=9913 GN=KIAA1671 PE=4 SV=1 CANONICAL=E1BC55-1" }, "locus": { "chromosome": "17", "start_pos": 65282643, "end_pos": 65189600, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073056.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073056.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105121.1" } ] } }, { "isoform_ac": "E1BC55-1", "url": "https://www.uniprot.org/uniprotkb/E1BC55/entry", "sequence": { "sequence": "MATRVEVGSISSLTGVPGLGELSKEEALTRTYFRQAGDAPGPPSTLLLEGKSPLRSPVRLLPLPRLAPKPFSKEKAADVTPLWPSLARPSPAGGLSQDVASGRLNEKMPGLAGQEAGSGDRPRNVSLFPKAAISQPMPNPVIFESNKAGPALGKGACEANAGMSQGPASAPRPEVAAKPAPPARKPVGSLPRPASLPQDSRTVATPEDTGPKEPLSKASSVEDAGGTAPEPPRPRPKRRPVSAIFTESIQTPKPGPSGVAAVGKLPPTPPEKTWVRRPRPLSVDLTARFESREALARKVADEATAGPTAQQRGPERPDPEPRVDRECLVKAEAPPHDPDSDFLQVAQKIQERKERLLLKQGEMGSLRTAGGPARVTPTSAQGLGEEKAKLDREPEKAAKDPQSPLPRPGKGQDMAEVRSREAAGETRVGGEQTPRGGVKNRIGLFGEEGASALAAGFESPPATPESPAIPPEPEKAGVSVQERIKGWATESSEAKPELRRRVVQTRPLSADLTKLFSSAASSNEVRYEKCLELSGELPREPREKPKDRHGVEGTSVTRSPWKPGLPREKPRQTERKDSFDRVPGGARGESAVGARSPSEGTPDDDGSFQTVWATVFENHVEKHTITAPSGRSPWATTPADLANVSEPRSRLLGPRSSFPQTTALKREWLEDPDLERGGGTAFSSGEPRQHRVSSLLGRHPGGEKGSHHPFLKLPESAPAPERVEPRYDVVHAVGERAHSEAVLTAPEEKALTLRSSRSRPPPSQEVTHAMTPADPKCRPEGQVGSVQRAGLIWEARGTREVSGPKPEFHREPKDTHGGSCPSPRWTGGVAVSWHKAAVGLSEGRGTEPSPEAASARTTLEAQHPGTEGAGIQPGERAPPRGAPPEPLPRARDEADDSRVQLQADVLGQTGPLAMAGSQEPEARRRRVSPGDQRLDRWRRRTLPHDVKFDEFSLLPPEHSSRAEPRGDHLSPTAPGALGKPQLLPGREGTGQGSPGTSLDWVLPAAKQGSPVEPKATFFAVTYQIPDTQKAKNVVRPGPENWTEPSRKAAPPLSPLSYTPTSVPLNREELLETVGGKNRALGREREHTSFPKPTEHPASLGDRILGSPGERISDADAVWVRRGPEGGGGFQNGWKDSGNKTSPGGAPQTPPAFRSPPKASELLVRRKTEAVSETFPGKAKAGYRSSVLDIDALMAEYQRPPAGSPREAQEWMAGSPAELRGSDPERPGPQDEADQRRRSLKERPEAEAPQRQASFAETSPGSTPGSGKYLAETPGAATHKVSSPLWGAPHSAPPEKNPGASSGPAAGPRKKGSGIPEDEKKTFVSKHHSAKCQHPSAESKPATAWVDPGGGASVQPKSSPADQRKGTPRKPPGRGEESGVVPWADHLRDLGRSPLDVKRAYSEKGPPLKIREGLSIMQEARERRQEQPKGRPSLPRESAEARDTKTGLCRQESGNRDSQKVSPRDLGRERALPDNEPPLRQVSPATVGPRRSHSFCKDRRSGPFVDQLKQCFSRRTPEAKDTDTLVQETDSQYGTWPDQRQSGESLAPESPSPDSSAASAWKQPPSSRLSSLSSQTEVTSAGDQHDCSREQRSTSVDRSSTDLESTDGMEGPPPPDACPAKKVDDFPFIDQTSVLDSSALKTRVQLSKRSRRRAPTAHSLRRSRTSEPDGRSAWEEEADSAWMFRDSTEEKSPRKEESDEEERTPRAERTPVSRPQRMPVFPGVDPAALKAQLYKRPDSPNETPGWAPQPKTPKSPFQPGVLGSRVLPSSMEKDERSEEPSPQWLKELKSKKRQSLYENQA", "length": 1800, "header": "tr|E1BC55-1|E1BC55_BOVIN Isoform 1 of KIAA1671 OS=Bos taurus OX=9913 GN=KIAA1671 PE=4 SV=3 CANONICAL=E1BC55-1" }, "locus": { "chromosome": "17", "start_pos": 65282643, "end_pos": 65155160, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061095.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061095.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053768.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053768.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1262, "start_aa": "Thr", "end_pos": 1262, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1262", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 268, "start_aa": "Thr", "end_pos": 268, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr268", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 308, "start_aa": "Thr", "end_pos": 308, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr308", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 376, "start_aa": "Thr", "end_pos": 376, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr376", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 378, "start_aa": "Thr", "end_pos": 378, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr378", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 463, "start_aa": "Thr", "end_pos": 463, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr463", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:533883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533883", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZ88-1", "protein_name": "KIAA1671 homolog", "gene_name": "Kiaa1671", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATRVEVGSIASLRAGPAGLGDIGREETLKRTYFCQTGDLPGASSTRIRSAKNPLQAHLFPLPIAPKPFLKDQVPERKASVKSSWSGGATQPRPSAQAAEEEAKEDLAKTMPSLAGEGADRGEALQNGPSVPNKATFLRSGPSTMGLFETTKAGPGLGKGTGEGSREASPRATQTSPLSARPEVATKPALPARKPPVTLPRPTSLSQDTGSAISQGEAGRAQPLPKAHSVEDPADQAPEAKPVRRRPLSAVFSEYLQPLKPGSGGVAVTGKVPPTPPEKTWVRKPRPLSVDLTSIFESGDTLLRKVTREQSTAERQGPERPGVEPRGNVESPARVDGTPRDPDAEFQELSKRLHARKEKMVLKQTDTDSPRAPRARATPGDDQSPQQEEAMPEQQWEKVQESPSPRPERGLGLTEVKGERLDQEASARTERKPAGSVRKRFSLFGEDSAGALAVVPEPSPVTPESPSSASTVSTASTVPEPSRAGVNVQARIKGWSVERAGEEKPEVWRRASQARPLPADLTKPFSRSASSSEIGYEKCATLGGELPGERREKLKERHGLDRPSATKSPWKSEASQKSRQTELKDASDQDPDRCWSARSVGGASPSEVSPEDDGSFQKVWATVFEHHVERHTVADQAGCCLSATPPFDVADTPDPRPKPENWPGKEPPGVTDERDRSRWSDRADLGMLGRPALVDVALRPYPTPVPGRHPMEERHSRSVPRHLESPPVSQRVQPKYDVMHASGERAHSEAVSTVPEEKAVTLHSGRSRLSLPARQLSQEVNPSYLDSSLQGSGGAVQRASQLWEARGKEGSRSKLDCQQPGDGFGGSCQSSKWAGVGVTNWHSSAVVSKDLGTAQRGQSWSVFSDLPSRASIEPRDSQVQAGIDSLSQQKGPLMVASEDNPRLAQVAQPEVRMWRSNPSEPRVDRLRRRTLPHDVKFDPFSLLGPESSSERQQRPADGLTFPTCALKRPHQQAQTQGGTPDASQGRTFLVEKLGPSAEPAATFFAVTYQVPDIQKAKSVVKPGPENVSEPSRKTPPPPSPRSVVSALPSPGREELWSPASSKGYAKGREYEEVRNLSKHPKSTDQPASAGDRTLDPSRERIIDVDALRFHRESEDDAVKYRNLGASSGEDASQTPLVLRRPRSLLMRRRTEVISETFPGKMRDGYRSSVLDLDSLMAEYKEQLSRSPSKAQEQQDSPTEPSGSPQERSGWPKEAEWRRRSLKEAPQSDGVGVGQQTGPSVKVLHSPGPSKQPAEPLGVAMATKSGLPLWAPPQSASGENCPSPSSVPAGSRRKSPGIAELESKPSSSEHQGTKRRQGSVKSQELGSGDPVSPRSPPSDRKKGTPRRSTVQGVEGNGVQWGTPPHDSVWSPMDIKRACSEKGPPARVREGLSVMQDARERRGEQSRGKPDLPAETPKVAEGPCQRDTRRLEGPKLPLQNLERRDGRQDGQQPLGQVSPVASVPRRSHSFCKDKRNSLLVNQLKQCFSRRAPEAKDTDTLVQEADSQYGTWAAQHQNGGSFGPETPSPDSSAASAGKQPPGSHLSSYTESTSVEQHDSSRDRRSSSVDRSSSELESTDGPEGPPPSDVCPAEGEDDFSFIHQTSVLDSSALKTRVQLSKRSRRRAPISHSLRRSQFSESESRSPLEEESHSAWMFKDSTEEKSPRRDESDEEPPRVERTPVGHPQRMPVFPGMDPAVLKAQLPKRSEVDSPGESLSWTPQPKTPKSPFQPGVLGSRVLPSSAEREERSEERSPQWLKELKSKKRQSLYENQA", "length": 1770 }, "evidence": [ { "id": "E1BC55", "url": "https://omabrowser.org/oma/group/E1BC55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BRV5-1", "protein_name": "Uncharacterized protein KIAA1671", "gene_name": "Kiaa1671", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDYYYCPSLLKLLRYLWNQLKQCFSRRAPEAKDTDTLVQEADSQYGTWADQHQNGGSFGPESPSPDSSAASVGKQPPGSHLSSYTESTSVEQRDSSRDRRSSSVDRSSSELESTDGPEGPPPSDVCPAQEDDFSFIHQTSVLDSSALKTRVQLSKRSRRRAPISHSLRRSQFSESESRSPLEEESHSTWMFKDSTEEKSPRRDESDEEPPRVERTPVSHPQRMPVFPGMDPAVLKAQLPKRSEVDSPGDSLSWTPQPKSPKSPFHPGVLGSRVLPPSTEKEERSEECSPQWLKELKSKKRQSLYENQA", "length": 308 }, "evidence": [ { "id": "E1BC55", "url": "https://omabrowser.org/oma/group/E1BC55/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BY89-1", "protein_name": "Uncharacterized protein KIAA1671", "gene_name": "KIAA1671", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATRVEVGSITPLTAVPGLGEMGKEETLTRTYFLQAGEASGAPPARILEAKSPLRSPARLLPLPRLAPKPFSKEQDVKSPVPSLRPSSTGPSPSGGLSEEPAAKDLDNRMPGLVGQEVGSGEGPRTSSPLFNKAVFLRPSSSTMILFETTKSGPALGKAVSEGAEEAKLGVSGSRPEVAAKPALPTQKPAGTLPRSAPLSQDTKPPVPQEEAGQDHPPSKASSVEDTARPLVEPRPRLKRRPVSAIFTESIQPQKPGPGAAATVGKVPPTPPEKTWVRKPRPLSMDLTARFENKEALLRKVADEGSGPTAGDMAGLERPRAASKLDRDCLVKAEAPLHDPDLDFLEVAKKIRERKEKMLSKPEMGSPRALVGGSSGVTPSNDQSPWEEKAKLDPEPEKAAESPSPRLGRGLELAEVKSRVADGEAAAGGEWASRRSVRKCISLFREDSTLALAVGSESPLATPASPSAAPEPEKGVVSVQERIRGWTAESSEAKPEVRRRTFQARPLSADLTKLFSSSASSNEVKYEKSAELSGEFPKEPREKQKEGHSLDGACIPRSPWKPGTLRDKSRQTEQKVSSNQDPDSCRGGSSVEAPCPSDVTPEDDRSFQTVWATVFEHHVERHTVADQSGRCLSTTPPGDMAHARVSEPRPRPEMGSWLGRDPPDMTKLKKENSRGFDNPETEKLGPTTLLNGELRPYHTPLRDKYPLSENHNNNTFLKHLENPPTSQRIEPRYDIVHAVGERVHSEAISPAPEEKAVTLRSLRSWLSLKDRQLSQEVTPADLECGLEGQAGSVQRASLIWEARGMPEASGPKFGGNCPFPKWTGGAVVSSHKATVAVSEEHCAPGATSVRAIKAAIWESQHEGPEGARSKPGVGARGPPQGCPLDPLSRATNGPSDSQARTHPDAFAVQKGPFIVAAREGDPGPAQVPQPAVRMRKAGAMDQRMDRWRRRTLPPNVKFDTFSSLVPEDSPHVGHRRTDYVSPTASALRKPQLSHYRVETQEVNPGASRDQTSPAVKQGSPVEPKATFFAVTYQIPNTQKAKGVVLSGAESLLEHSRKITPPSSPHSLTSTLVSLGHEEALEMAGSKNWMKGREHENASILKTLKPTDRPSSLGAWSLDPFNGRIIDVDALWSHRGSEDGPRPQSNWKESANKMSPSGGAPQTTPTLRSRPKDLPVRRKTDVISDTFPGKIRDGYRSSVLDIDALMAEYQELSLKVPGEAQERRSPTVEPSTLPRERPVQLGGVEQRRRSLKEMPDTGGLWKPASSAEINHSFTPGLGKQLAETLETAMGTKSSPPFWALPPSAPSERYPGGSPIPADPRKKTGFAEDDRKAFASKHHVAKCQNYLAESKPSGREDPGSGVRVSPKSPPTDQKKGTPRKSTGRGEEDSVAQWGDHPRDCGRVPLDIKRAYSEKGPPANIREGLSIMHEARERRREQPKGRPSLTGENLEAKMGPCWWESGTGDSHKVLPRDLEKEDAPQEKERPLQQVSPVASVPWRSHSFCKDRRSGPFVDQLKQCFSRQPTEPKDTDTLVHEAGSQYGTWTEQCQSGESLATESPDSSATSTRKQPPSSRLSSLSSQTEPTSAGDQYDCSRDQRSTSVDHSSTDLESTDGMEGPPPPDACPEKRVDDFSFIDQTSVLDSSALKTRVQLSKRSRRRAPISHSLRRSRFSESESRSPLEDETDNTWMFKDSTEEKSPRKEESDEEETASKAERTPVSHPQRMPAFPGMDPAVLKAQLHKRPEVDSPGETPSWAPQPKSPKSPFQPGVLGSRVLPSSMDKDERSDEPSPQWLKELKSKKRQSLYENQV", "length": 1806 }, "evidence": [ { "id": "E1BC55", "url": "https://omabrowser.org/oma/group/E1BC55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E1BC55", "url": "https://www.uniprot.org/uniprotkb/E1BC55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1040, "end_pos": 1042, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1138, "end_pos": 1140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1740, "end_pos": 1742, "annotation": "n_glycosylation_sequon" }, { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC55" }, { "id": "SM01319", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01319" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tankyrase 1-binding protein C-terminal", "eco_id": "ECO_0000259", "start_pos": 1622, "end_pos": 1791, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 268, 308, 376, 378, 463, 1262 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1040, "end_pos": 1042 }, { "start_pos": 1138, "end_pos": 1140 }, { "start_pos": 124, "end_pos": 126 }, { "start_pos": 1740, "end_pos": 1742 }, { "start_pos": 643, "end_pos": 645 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B792-1", "uniprot_ac": "E1B792", "uniprot_id": "E1B792_BOVIN", "mass": { "chemical_mass": 75173.0, "monoisotopic_mass": 75173.0 }, "refseq": { "ac": "XP_024839117", "name": "chloride channel protein ClC-Ka isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839117" }, "gene_names": [ { "name": "CLCNKA", "type": "recommended", "evidence": [ { "id": "E1B792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ] }, { "name": "CLCNKA", "type": "synonym", "evidence": [ { "id": "XP_024839117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839117" } ] } ], "protein_names": [ { "name": "Chloride voltage-gated channel Ka", "type": "synonym", "evidence": [ { "id": "E1B792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B792/entry#names_and_taxonomy" } ] }, { "name": "chloride channel protein ClC-Ka isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839117", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839117" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLCNKA", "url": "https://www.uniprot.org/uniprotkb/E1B792", "locus": {} } ], "crossref": [ { "id": "E1B792", "url": "https://alphafold.ebi.ac.uk/entry/E1B792", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034674", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034674", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03683", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03683", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04591", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04591", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538145", "url": "https://www.ncbi.nlm.nih.gov/gene/538145", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "5TQQ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5TQQ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "5TR1", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=5TR1&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR001807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538145", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538145", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVCCIHP", "url": "https://omabrowser.org/oma/group/EVCCIHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M042", "url": "https://www.orthodb.org/?gene=A0A3Q1M042", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B792", "url": "https://www.orthodb.org/?gene=E1B792", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45720", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45720", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45720:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45720:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00005tqq", "url": "https://www.rcsb.org/structure/pdb_00005tqq", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00005tr1", "url": "https://www.rcsb.org/structure/pdb_00005tr1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5TQQ", "url": "https://www.rcsb.org/structure/5TQQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5TR1", "url": "https://www.rcsb.org/structure/5TR1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024839117", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839117", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34923", "url": "https://www.rhea-db.org/rhea/34923", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66324", "url": "https://www.rhea-db.org/rhea/66324", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "75383", "url": "https://www.rhea-db.org/rhea/75383", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M042", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M042", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M042-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M042-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B792-1", "url": "https://www.uniprot.org/uniprotkb/E1B792-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEELVGLRERSSGNPVTLQELWGPCPRVRRGIRGGLDWLKRKLFCVGEDWYFLTVLGVLMALISFTMSFTVGRVVRAHKWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPFSGGSGIPELKTILSGVVLEDYLDIKNFGAKAVGLTCTLASGSTIFLGKVGPFVHLSVMIAAYLGRVRAKATGESENKSKRNEMLVAGAAVGVATVFAAPFSGVLFCIEVVSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVEVPFDLPEIFFFVALGAICGVASCAYLFCQRKFLGFVKTNPVLSKLMATSKPLYSALAALVLASVTYPPGAGRFMASRLSMREYLDSLLDHNSWALLTRNASPPWPVEPDPQNLWFEWYHPQFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIFGAAIGRLLGEALSVAFPEGIVAGGVTNPIMPGGYALAGAAAFSGAVTHSISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPWIRGRKISSHRVTVEHFMNRAITTLAKDTPQEEVVKVVTSTDMAEYPLVASTESQTLVGTMRRAQLVQALQAEPPSWAPGQQRCLQDILAEGCPVEPVTLKLSPETSLHQAHNLFELLNLQSLFVTSQGRAVGFVSWVELEKAISKLTNPPAPK", "length": 687, "header": "tr|E1B792-1|E1B792_BOVIN Isoform 1 of Chloride voltage-gated channel Ka OS=Bos taurus OX=9913 GN=CLCNKA PE=1 SV=1 CANONICAL=E1B792-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M042-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M042/entry", "sequence": { "sequence": "GLDWLKRKLFCVGEDWYFLTVLGVLMALISFTMSFTVGRVVRGSGIPELKTILSGVVLEDYLDIKNFGAKAVGLTCTLASGSTIFLGKVGPFVHLSVMIAAYLGRVRAKATGESENKSKRNEMLVAGAAVGVATVFAAPFSGVLFCIEVVSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVEVPFDLPEIFFFVALGAICGVASCAYLFCQRKFLGFVKTNPVLSKLMATSKPLYSALAALVLASVTYPPGAGRFMASRLSMREYLDSLLDHNSWALLTRNASPPWPVEPDPQNLWFEWYHPQFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIFGAAIGRLLGEALSVAFPEGIVAGGVTNPIMPGGYALAGAAAFSGAVTHSISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPWIRGRKISSHRVTVEHFMNRAITTLAKDTPQEEVVKVVTSTDMAEYPLVASTESQTLVGTMRRAQLVQALQAEPPSWAPGQQRCLQDILAEGCPVEPVTLKLSPETSLHQAHNLFELLNLQSLFVTSQGRAVGFVSWVELEKAISKLTNPPAPK", "length": 610, "header": "tr|A0A3Q1M042-1|E1B792_BOVIN Computationally mapped isoform of Chloride voltage-gated channel Ka OS=Bos taurus OX=9913 GN=CLCNKA PE=1 SV=2 CANONICAL=E1B792-1" }, "locus": { "chromosome": "2", "start_pos": 136048617, "end_pos": 136037551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076715.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076715.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062985.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062985.2" } ] } }, { "isoform_ac": "E1B792-1", "url": "https://www.uniprot.org/uniprotkb/E1B792/entry", "sequence": { "sequence": "MEELVGLRERSSGNPVTLQELWGPCPRVRRGIRGGLDWLKRKLFCVGEDWYFLTVLGVLMALISFTMSFTVGRVVRAHKWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPFSGGSGIPELKTILSGVVLEDYLDIKNFGAKAVGLTCTLASGSTIFLGKVGPFVHLSVMIAAYLGRVRAKATGESENKSKRNEMLVAGAAVGVATVFAAPFSGVLFCIEVVSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVEVPFDLPEIFFFVALGAICGVASCAYLFCQRKFLGFVKTNPVLSKLMATSKPLYSALAALVLASVTYPPGAGRFMASRLSMREYLDSLLDHNSWALLTRNASPPWPVEPDPQNLWFEWYHPQFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIFGAAIGRLLGEALSVAFPEGIVAGGVTNPIMPGGYALAGAAAFSGAVTHSISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPWIRGRKISSHRVTVEHFMNRAITTLAKDTPQEEVVKVVTSTDMAEYPLVASTESQTLVGTMRRAQLVQALQAEPPSWAPGQQRCLQDILAEGCPVEPVTLKLSPETSLHQAHNLFELLNLQSLFVTSQGRAVGFVSWVELEKAISKLTNPPAPK", "length": 687, "header": "tr|E1B792-1|E1B792_BOVIN Isoform 1 of Chloride voltage-gated channel Ka OS=Bos taurus OX=9913 GN=CLCNKA PE=1 SV=1 CANONICAL=E1B792-1" }, "locus": { "chromosome": "2", "start_pos": 136049304, "end_pos": 136037551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049019.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049019.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045967.2", "url": "https://www.ensembl.org/id/ENSBTAP00000045967.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure of a CLC chloride ion channel by cryo-electron microscopy.", "journal": "Nature", "date": "2017", "authors": "Park Eunyong, Campbell Ernest B, MacKinnon Roderick", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "reference": [ { "type": "PubMed", "id": "28002411", "url": "https://glygen.org/publication/PubMed/28002411" } ] } ], "pathway": [ { "id": "bta:538145", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538145", "resource": "KEGG Pathway" }, { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [ { "uniprot_canonical_ac": "P51801-1", "protein_name": "Chloride channel protein ClC-Kb", "gene_name": "CLCNKB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK", "length": 687 }, "evidence": [ { "id": "E1B792", "url": "https://omabrowser.org/oma/group/E1B792/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WUB7-1", "protein_name": "Chloride channel protein ClC-Ka", "gene_name": "Clcnka", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEELVGLREGSSGKPVTLQELWGPCPRIRRGIRGGLEWLKERLFRAREDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPVALLSFSSGFSQSITPFSGGSGLPELKTMLSGVVLENYLDIKNFGAKVVGLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKAVGDTESKAKEVEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLAVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGILSCVYLFCQRNFLRFIKTNRYTSKLLATSKPSYAALVALVLASVTYPPGVGRFMASRLSMAEHLHSLFDNNSWALMTRNASPPWPSEPDPQNLWFEWYHPRFTIFGTLAFFLIMKFWMLILATTIPMPAGYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGGEVYPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANVISQNLQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNSNLTTLAKDMPLEEVVKVVTSTDVSQYPLVETRESQTLVGIVERTHLVQALQTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHRLFELLTLQALFVTSRGRAVGSVSWVELKKAISTLINPPAPK", "length": 687 }, "evidence": [ { "id": "E1B792", "url": "https://omabrowser.org/oma/group/E1B792/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "pmid": "" }, { "name": "chloride channel complex", "id": "GO:0034707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "pmid": "" }, { "name": "voltage-gated chloride channel activity", "id": "GO:0005247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005247", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chloride transport", "id": "GO:0006821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006821", "evidence": [ { "database": "UniProtKB", "id": "E1B792", "url": "https://www.uniprot.org/uniprotkb/E1B792" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29823", "name": "", "equation": "chloride(in) = chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN01-1", "Q5E9B7-1", "Q9XSA7-1", "P35071-1", "P35526-1" ], "evidence": [ { "id": "29823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29823" } ] }, { "id": "34923", "name": "", "equation": "nitrate(in) = nitrate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B7-1", "Q9XSA7-1" ], "evidence": [ { "id": "34923", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34923" } ] }, { "id": "66324", "name": "", "equation": "iodide(out) = iodide(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B7-1", "Q9XSA7-1" ], "evidence": [ { "id": "66324", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66324" } ] }, { "id": "75383", "name": "", "equation": "bromide(in) = bromide(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B7-1", "Q9XSA7-1" ], "evidence": [ { "id": "75383", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75383" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] }, { "uniprot_ac": "Q5E9B7", "gene_name": "CLIC1", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] } ] }, { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B792-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 687, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B792-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B792" }, { "pdb_id": "5tqq", "pdb_chain": "a/b", "start_pos": 27, "end_pos": 687, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/5tqq.pdb", "url_external": "https://www.rcsb.org/structure/5tqq" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 }, { "start_pos": 373, "end_pos": 375 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA82-1", "uniprot_ac": "E1BA82", "uniprot_id": "E1BA82_BOVIN", "mass": { "chemical_mass": 118716.0, "monoisotopic_mass": 118716.0 }, "refseq": { "ac": "NP_001178205", "name": "ubiquitin-associated protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178205" }, "gene_names": [ { "name": "UBAP2", "type": "recommended", "evidence": [ { "id": "E1BA82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA82" } ] }, { "name": "UBAP2", "type": "synonym", "evidence": [ { "id": "NP_001178205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178205" } ] } ], "protein_names": [ { "name": "Ubiquitin associated protein 2", "type": "synonym", "evidence": [ { "id": "E1BA82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA82/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-associated protein 2", "type": "synonym", "evidence": [ { "id": "NP_001178205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178205" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA82", "url": "https://www.uniprot.org/uniprotkb/E1BA82" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBAP2", "url": "https://www.uniprot.org/uniprotkb/E1BA82", "locus": { "chromosome": "8", "start_pos": 75335468, "end_pos": 75454071, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000695", "url": "https://www.ensembl.org/id/ENSBTAG00000000695" } ] } } ], "crossref": [ { "id": "E1BA82", "url": "https://alphafold.ebi.ac.uk/entry/E1BA82", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000695", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14277", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14277", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506577", "url": "https://www.ncbi.nlm.nih.gov/gene/506577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SPSIDEC", "url": "https://omabrowser.org/oma/group/SPSIDEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0X9", "url": "https://www.orthodb.org/?gene=A0A3Q1M0X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BA82", "url": "https://www.orthodb.org/?gene=E1BA82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16308", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16308", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16308:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16308:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12478", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12478", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28540", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28540", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178205", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M482", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M482", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M482-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M482-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA82", "url": "https://www.uniprot.org/uniprotkb/E1BA82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA82-1", "url": "https://www.uniprot.org/uniprotkb/E1BA82-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTSVSSDRSRGAREKPQISATQATQLQKQVVQATAEQMRLAQVIFDKNDSEFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINVLLEGNSDTTSWETVGGKKKNFGKESSENKENREKRSEREVSRGRGNNNRKVRGGNRGREFRGEENGIDCNQGDKPSDRGKRARGRGFGRGRGRGAGRFSTQGMGTFNPADYSDSPSIDGCGTKPVVWEAAQNGADEGTELASDAQNVAQNLSNKNSFGIKGAWKNSVEEWTAEDWTEDLSETKVFTSSSVPAENHVTPGQSVDLVALLQKPVPPSQAPEVNSFETSQQQSFGQALVFTNSQHNNQMAPGTGSSDAVNSYPPQSLSSVLGSGFGELAPSKMANITSSQILDQLKAPSLGQFTTTSSSQQSSTSSPTTTSSWDLKPPASQSSVLSHFDFKSQPEPSPVLSQLSQRQQHQTQAVTVPPPGLESFPSQVKLREAAPRDSSTSTVNKLLQLPSMTVENIAVSAHQPQPKHIKLPKSRRIPPASKIPASAVEMPGSADVTGLNVQFGALEFGSEPSLSEFGSSASSENSSQIPISLYSKSLSDSLNTSLPMTSAVQNSTYTTSVITSSSLTSSSLSSTSPVTTSSSYDQSSVHNRIAYQSSVSPSESAPGTVTNGHGGSRSQQTVDTTSSVPAPKTTDPPSALPSVASLPSTTSCAPLLPPASQHTATLPSLSQPGDLSSSPLSQLSSSLSSHQSSLASTHMPLSASTSHTHASVDSAPSLQPSATFSTAATSASSAVSSGLSLPSGMNTVSSLCLGNAPGSAPSSSARAAPLMTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFATPPALANRDGSLTNNPYSGDVTKFGRGDSASPAPPTTLAQPQQSQSQAHHTAQQPFLSPALPPGYSYTGLPYYTGVPSAFQYGPTMFVPPASAKQHGVSLSTPSTPFQQASGYGQHSYGTGYDDLTPGTAAGDYSKGGYGGSSQTQNKAAGSGPGKGVSATSSTSGLPDMTGSVYNKTQTFDKQGFHAGTPPPFGLPSALGSTGPLAPGAAPGYAPPPFLHILPAHQQAPSQLLHHHLPQDAQSGSGQRNQPSSLQPKSQASKPAYGNSPYWTN", "length": 1137, "header": "tr|E1BA82-1|E1BA82_BOVIN Isoform 1 of Ubiquitin associated protein 2 OS=Bos taurus OX=9913 GN=UBAP2 PE=4 SV=3 CANONICAL=E1BA82-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0X9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X9/entry", "sequence": { "sequence": "MMTSVSSDRSRGAREKPQISATQATQLQKQVVQATAEQMRLAQVIFDKNDSEFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINVLLEGNSDTTSWETVGGKKKNFGKESSENKENREKRSEREVSRGRGNNNRKVRGGNRGREFRGEENGIDCNQGDKPSDRGKRARGRGFGRGRGRGAGRFSTQGMGTFNPADYSDSPSIDGCGTKPVVWEAAQNGADEGTGAWKNSVEEWTAEDWTEDLSETKVFTSSSVPAENHVTPGQSVDLVALLQKPVPPSQAPEVNSFETSQQQSFGQALVFTNSQHNNQMAPGTGSSDAVNSYPPQSLDDLMADLSVTNPSKNLAKLKSSVLGSGFGELAPSKMANITSSQILDQLKAPSLGQFTTTSSSQQSSTSSPTTTSSWDLKPPASQSSVLSHFDFKSQPEPSPVLSQLSQRQQHQTQAVTVPPPGLESFPSQVKLREAAPRDSSTSTVNKLLQLPSMTVENIAVSAHQPQPKHIKLPKSRRIPPASKIPASAVEMPGSADVTGLNVQFGALEFGSEPSLSEFGSSASSENSSQIPISLYSKSLSDSLNTSLPMTSAVQNSTYTTSVITSSSLTSSSLSSTSPVTTSSSYDQSSVHNRIAYQSSVSPSESAPGTVTNGHGGSRSQQTVDTTSSVPAPKTTDPPSALPSVASLPSTTSCAPLLPPASQHTATLPSLSQPGDLSSSPLSQLSSSLSSHQSSLASTHMPLSASTSHTHASVDSAPSLQPSATFSTAATSASSAVSSGLSLPSGMNTVSSLCLGNAPGSAPSSSARAAPLMTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFATPPALANRDGSLTNNPYSGDVTKFGRGDSASPAPPTTLAQPQQSQSQAHHTAQQPFLSPALPPGYSYTGLPYYTGVPSAFQYGPTMFVPPASAKQHGVSLSTPSTPFQQASGYGQHSYGTGYDDLTPGTAAGDYSKGGYGGSSQTQNKAAGSGPGKGVSATSSTSGLPDMTGSVYNKTQTFDKQGFHAGTPPPFGLPSALGSTGPLAPGAAPGYAPPPFLHILPAHQQAPSQLLHHHLPQDAQSGSGQRNQPSSLQPKSQASKPAYGNSPYWTN", "length": 1135, "header": "tr|A0A3Q1M0X9-1|E1BA82_BOVIN Computationally mapped isoform of Ubiquitin associated protein 2 OS=Bos taurus OX=9913 GN=UBAP2 PE=4 SV=2 CANONICAL=E1BA82-1" }, "locus": { "chromosome": "8", "start_pos": 75422823, "end_pos": 75336302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082948.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082948.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061666.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061666.2" } ] } }, { "isoform_ac": "A0A3Q1M482-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M482/entry", "sequence": { "sequence": "MMTSVSSDRSRGAREKPQISATQATQLQKQVVQATAEQMRLAQVIFDKNDSEFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINVLLEGNSDTDLGVAEGEGQEDSQPKAWDIAKCSLGGRCTTTPVENHCLRIMLVNPAVVFEWTFNPADYSDSPSIDGCGTKPVVWEAAQNGADEGTGAWKNSVEEWTAEDWTEDLSETKVFTSSSVPAENHVTPGQSVDLVALLQKPVPPSQAPEVNSFETSQQQSFGQALVFTNSQHNNQMAPGTGSSDAVNSYPPQSLSSVLGSGFGELAPSKMANITSSQILDQLKAPSLGQFTTTSSSQQSSTSSPTTTSSWDLKPPASQSSVLSHFDFKSQPEPSPVLSQLSQRQQHQTQAVTVPPPGLESFPSQVKLREAAPRDSSTSTVNKLLQLPSMTVENIAVSAHQPQPKHIKLPKSRRIPPASKIPASAVEMPGSADVTGLNVQFGALEFGSEPSLSEFGSSASSENSSQIPISLYSKSLSDSLNTSLPMTSAVQNSTYTTSVITSSSLTSSSLSSTSPVTTSSSYDQSSVHNRIAYQSSVSPSESAPGTVTNGHGGSRSQQTVDTTSSVPAPKTTDPPSALPSVASLPSTTSCAPLLPPASQHTATLPSLSQPGDLSSSPLSQLSSSLSSHQSSLASTHMPLSASTSHTHASVDSAPSLQPSATFSTAATSASSAVSSGLSLPSGMNTVSSLCLGNAPGSAPSSSARAAPLMTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFATPPALANRDGSLTNNPYSGDVTKFGRGDSASPAPPTTLAQPQQSQSQAHHTAQQPFLSPALPPGYSYTGLPYYTGVPSAFQYGPTMFVPPASAKQHGVSLSTPSTPFQQASGYGQHSYGTGYDDLTPGTAAGDYSKGGYGGSSQTQNKAAGSGPGKGVSATSSTSGLPDMTGSVYNKTQTFDKQGFHAGTPPPFGLPSALGSTGPLAPGAAPGYAPPPFLHILPAHQQAPSQLLHHHLPQDAQSGSGQRNQPSSLQPKSQASKPAYGNSPYWTN", "length": 1071, "header": "tr|A0A3Q1M482-1|E1BA82_BOVIN Computationally mapped isoform of Ubiquitin associated protein 2 OS=Bos taurus OX=9913 GN=UBAP2 PE=4 SV=2 CANONICAL=E1BA82-1" }, "locus": { "chromosome": "8", "start_pos": 75422823, "end_pos": 75336302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070963.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070963.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064610.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064610.2" } ] } }, { "isoform_ac": "E1BA82-1", "url": "https://www.uniprot.org/uniprotkb/E1BA82/entry", "sequence": { "sequence": "MMTSVSSDRSRGAREKPQISATQATQLQKQVVQATAEQMRLAQVIFDKNDSEFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINVLLEGNSDTTSWETVGGKKKNFGKESSENKENREKRSEREVSRGRGNNNRKVRGGNRGREFRGEENGIDCNQGDKPSDRGKRARGRGFGRGRGRGAGRFSTQGMGTFNPADYSDSPSIDGCGTKPVVWEAAQNGADEGTELASDAQNVAQNLSNKNSFGIKGAWKNSVEEWTAEDWTEDLSETKVFTSSSVPAENHVTPGQSVDLVALLQKPVPPSQAPEVNSFETSQQQSFGQALVFTNSQHNNQMAPGTGSSDAVNSYPPQSLSSVLGSGFGELAPSKMANITSSQILDQLKAPSLGQFTTTSSSQQSSTSSPTTTSSWDLKPPASQSSVLSHFDFKSQPEPSPVLSQLSQRQQHQTQAVTVPPPGLESFPSQVKLREAAPRDSSTSTVNKLLQLPSMTVENIAVSAHQPQPKHIKLPKSRRIPPASKIPASAVEMPGSADVTGLNVQFGALEFGSEPSLSEFGSSASSENSSQIPISLYSKSLSDSLNTSLPMTSAVQNSTYTTSVITSSSLTSSSLSSTSPVTTSSSYDQSSVHNRIAYQSSVSPSESAPGTVTNGHGGSRSQQTVDTTSSVPAPKTTDPPSALPSVASLPSTTSCAPLLPPASQHTATLPSLSQPGDLSSSPLSQLSSSLSSHQSSLASTHMPLSASTSHTHASVDSAPSLQPSATFSTAATSASSAVSSGLSLPSGMNTVSSLCLGNAPGSAPSSSARAAPLMTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFATPPALANRDGSLTNNPYSGDVTKFGRGDSASPAPPTTLAQPQQSQSQAHHTAQQPFLSPALPPGYSYTGLPYYTGVPSAFQYGPTMFVPPASAKQHGVSLSTPSTPFQQASGYGQHSYGTGYDDLTPGTAAGDYSKGGYGGSSQTQNKAAGSGPGKGVSATSSTSGLPDMTGSVYNKTQTFDKQGFHAGTPPPFGLPSALGSTGPLAPGAAPGYAPPPFLHILPAHQQAPSQLLHHHLPQDAQSGSGQRNQPSSLQPKSQASKPAYGNSPYWTN", "length": 1137, "header": "tr|E1BA82-1|E1BA82_BOVIN Isoform 1 of Ubiquitin associated protein 2 OS=Bos taurus OX=9913 GN=UBAP2 PE=4 SV=3 CANONICAL=E1BA82-1" }, "locus": { "chromosome": "8", "start_pos": 75422823, "end_pos": 75336302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000930.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000930.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000930.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000930.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 285, "start_aa": "Thr", "end_pos": 285, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr285", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506577", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0U1RRQ3-1", "protein_name": "Ubiquitin-associated protein 2", "gene_name": "Ubap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIVAEVLGKNHRCQQHTQHSHRNKWYSCTDLLTLLELSLATAEQMRLAQVIFDKNDSDFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINTLLEGSSDTTSWETVGGKKKNFGRESSENKENREKRTEREASRGRGNNNRKGRGGSRGREFKGEENGVDCSQGDKPSERGKRTRGRGFGRGRGRGAGRLSAQSMGTFNPADYSESMSTDGCGTKLVVWEAAQNGTDEGPEGLAKPHSISQELPSKSSYGLKGAWKNSVEEWTAEDWTEDLSETKVFTASSAPADNHVPPGQSIDLVALLHKPAPPTQAAEVNSFETSQQQGFGQALVFTNSQHNNPTAPGTASSTPASSYSPQSLSSVLGSGFGELAQSKMVNISNSQILDKLKPPGLSPFPAASSTQQNDNASPPATTAAWDLKPSAPQPSVLSHLDFKSQPEPSPVLSQLSQRQQQQNQAVSVPPPGLESFPSQTKHRESAPGDGPSTVNRLLQLPTMAVENIVSAHQPQPKHIKLPKRRIPPASKVPVSAVEMPGSADITGLNVQFGALEFGSEPSLSEFGSTASASENSSQLPISLYPKSLSEPLNASFPMTSAVQNPTYTTSVITSSTLTSSSVSSTSPVTTCSSYDQSSVHTRIAYQSPASPADAAPGSVANGHGGGRSQHTVDTTSSVPAPKKTDPSALPSVSSLPSPSSCTALLPPSSQHTATLPALTPGELSSSPLSQLSSSLSSHQSSLSSTHATRSTSTPHTHASVESTPSSAAFSAATSAPSAPSSGVALPGSMSTVSSLCLGGTTVSAPSSSTRATALVTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFAAPTALASRDGNLANNPYSGDVTKFGRGDSASPAPPTTPAQAQQSQSQTHHTAQQPFLNPALPPGYSYTGLPYYTGVPGAFQYGPTMFVPPTSAKQHGVTLSTPPTPFQQASGYGQHAYSAGYDDLTQGTAAGDYTKGGYGGSSQAPNKSAGSGPSKGVSVSSGTGLPDMTGSVYNKTQTFDKQGFHTGTPPPFSLPSALGSTGPLAPGAAPGYAPAPFLHIMPAHQQPHSQLLHHHLPQDAPSGSGQRSQPSSLQPKSQASKPTYGNSPYWTN", "length": 1135 }, "evidence": [ { "id": "E1BA82", "url": "https://omabrowser.org/oma/group/E1BA82/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T6F2-1", "protein_name": "Ubiquitin-associated protein 2", "gene_name": "UBAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMTSVSSDHCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQVIFDKNDSDFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINILLEGNSDTTSWETVGCKKKNFAKENSENKENREKKSEKESSRGRGNNNRKGRGGNRGREFRGEENGIDCNQVDKPSDRGKRARGRGFGRGRGRGAGRFSTQGMGTFNPADYSDSTSTDVCGTKLVVWEAAQNGADEGTELASNTHNIAQDLSNKSSYGLKGAWKNSVEEWTTEDWTEDLSETKVFTASSAPAENHILPGQSIDLVALLQKPVPHSQASEANSFETSQQQGFGQALVFTNSQHNNQMAPGTGSSTAVNSCSPQSLSSVLGSGFGELAPPKMANITSSQILDQLKAPSLGQFTTTPSTQQNSTSHPTTTTSWDLKPPTSQSSVLSHLDFKSQPEPSPVLSQLSQRQQHQSQAVTVPPPGLESFPSQAKLRESTPGDSPSTVNKLLQLPSTTIENISVSVHQPQPKHIKLAKRRIPPASKIPASAVEMPGSADVTGLNVQFGALEFGSEPSLSEFGSAPSSENSNQIPISLYSKSLSEPLNTSLSMTSAVQNSTYTTSVITSCSLTSSSLNSASPVAMSSSYDQSSVHNRIPYQSPVSSSESAPGTIMNGHGGGRSQQTLDTPKTTGPPSALPSVSSLPSTTSCTALLPSTSQHTGDLTSSPLSQLSSSLSSHQSSLSAHAALSSSTSHTHASVESASSHQSSATFSTAATSVSSSASSGASLSSSMNTANSLCLGGTPASASSSSSRAAPLVTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPVDYYGIPFAAPTALASRDGSLANNPYPGDVTKFGRGDSASPAPATTPAQPQQSQSQTHHTAQQPFVNPALPPGYSYTGLPYYTGMPSAFQYGPTMFVPPASAKQHGVNLSTPTPPFQQASGYGQHGYSTGYDDLTQGTAAGDYSKGGYAGSSQAPNKSAGSGPGKGVSVSSSTTGLPDMTGSVYNKTQTFDKQGFHAGTPPPFSLPSVLGSTGPLASGAAPGYAPPPFLHILPAHQQPHSQLLHHHLPQDAQSGSGQRSQPSSLQPKSQASKPAYGNSPYWTN", "length": 1119 }, "evidence": [ { "id": "E1BA82", "url": "https://omabrowser.org/oma/group/E1BA82/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91VX2-1", "protein_name": "Ubiquitin-associated protein 2", "gene_name": "Ubap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMTSVSNDRCRGAREKPQMPTAHAAQSQKQVVQATAEQMRLAQVIFDKNDSDFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINILLEGNSDTTSWETVGGKKKNFGRESSENKENREKRTEREASRGRGTNNRKGRGGNRVREFKGEENGIDCSQGDKPAERGKRARGRGFGRGRGRGTGRFSAQSMGTFNPADYSESMSTDGCGTKLAVWEAAQNGTDEGPEGLAKSHSMSQEPPSKSSYGLKGAWKNSVEEWTTEDWTEDLSETKVFTASSAPAENHVTPGHSIDLVALLHKPAPPTQATEVNSFETSQQQGFGQALVFTNSQHNNQMAPGTANSTSASSYSPQSLSSVLGSGFGELPQSNMVNISNSQILDKLKPPGLSPFPAASSAQQNDTASPPATTAAWDLKPSAPQPSVLSRLDFKSQPEPSPVLSQLSQRQQHQTQAVSVPPPGLESFSSLAKPRESTAGDGPSTVSRLLQLPNMTVENIVSAHQPQPKHIKLPKRRVPPASKVPVSAVEMPGSSDVTGLNVQFGALEFGSEPSLSEFGSAASASENSNQIPISLYPKSLSEPLNASFPMTSAVQSSTYTTSVVTSSTLTSSALSSTSPVTTSSSYDQSSVHTRIAYQSSASPPDSAPGSVANGHGGGRSQHTVDTTSSVPAPKKTDPSALPSVSTLPGPASCTALLPSSAQHTATLPSLTPAAAELSSSPLSQLSSSLSGHQNSMTSAHATRSTSTPHTHASVESTASSAAFSAAATSAPSAPSSGVVLPGSMSTVSSLCLGGTTVSVPSSSTRATALVTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPMDYYGIPFAAPTALASRDGNLANNPYSGDVTKFGRGDSASPAPPTTPAQAQQSQSQTHHTAQQPFLNPGLPPGYSYTGLPYYTGVPSAFQYGPTMFVPPTSAKQHGVALSTPPTPFQQASGYGQHAYSTGYDDLTQGTAAGDYTKGGYGGSSQAPNKSTGSGPGKGVSVSSGTGLPDMTGSVYNKTQTFDKQGFHAGTPPPFSLPSALGSTGPLAPAAAPGYAPAPFLHIMPAHQQPHSQLLHHHLQQDAPSGSGQRSQPSSLQPKSQASKPTYGSAPYWTN", "length": 1132 }, "evidence": [ { "id": "E1BA82", "url": "https://omabrowser.org/oma/group/E1BA82/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BA82", "url": "https://www.uniprot.org/uniprotkb/E1BA82" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BA82", "url": "https://www.uniprot.org/uniprotkb/E1BA82" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "E1BA82", "url": "https://www.uniprot.org/uniprotkb/E1BA82" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "hematopoietic stem cell homeostasis", "id": "GO:0061484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061484", "evidence": [ { "database": "UniProtKB", "id": "E1BA82", "url": "https://www.uniprot.org/uniprotkb/E1BA82" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 560, "end_pos": 562, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA82-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1137, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA82-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA82" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA82" }, { "id": "PS50030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 92, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 285 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 238, "end_pos": 240 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 560, "end_pos": 562 }, { "start_pos": 578, "end_pos": 580 }, { "start_pos": 589, "end_pos": 591 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBE5-1", "uniprot_ac": "E1BBE5", "uniprot_id": "E1BBE5_BOVIN", "mass": { "chemical_mass": 58186.0, "monoisotopic_mass": 58186.0 }, "refseq": { "ac": "NP_001180108", "name": "interleukin-21 receptor precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180108" }, "gene_names": [ { "name": "IL21R", "type": "recommended", "evidence": [ { "id": "E1BBE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBE5" } ] }, { "name": "IL21R", "type": "synonym", "evidence": [ { "id": "NP_001180108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180108" } ] } ], "protein_names": [ { "name": "Interleukin 21 receptor", "type": "synonym", "evidence": [ { "id": "E1BBE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBE5/entry#names_and_taxonomy" } ] }, { "name": "interleukin-21 receptor precursor", "type": "synonym", "evidence": [ { "id": "NP_001180108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180108" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBE5", "url": "https://www.uniprot.org/uniprotkb/E1BBE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL21R", "url": "https://www.uniprot.org/uniprotkb/E1BBE5", "locus": { "chromosome": "25", "start_pos": 25006402, "end_pos": 24966488, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019567", "url": "https://www.ensembl.org/id/ENSBTAG00000019567" } ] } } ], "crossref": [ { "id": "E1BBE5", "url": "https://alphafold.ebi.ac.uk/entry/E1BBE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019567", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019567", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617967", "url": "https://www.ncbi.nlm.nih.gov/gene/617967", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617967", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617967", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGWAAPL", "url": "https://omabrowser.org/oma/group/CGWAAPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBE5", "url": "https://www.orthodb.org/?gene=E1BBE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23037:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-9020958", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020958", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001180108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180108", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1Z6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBE5", "url": "https://www.uniprot.org/uniprotkb/E1BBE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBE5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCAWAATLLLLMLQGTWGCSNLVCYTDYIETITCILDTWARHPDSLTLTWHDTYGELEDEVTSCSLLRSTHNATHVEYTCHMNVFRLMADDFFNVSMTDPSGNYSQECGSFIVAASIKPSPPFNVTVNFSGYYNVSWSSSSSFSPSDRVYALKDKLQYELRYRKVGEPWAQSPGRKLISEDSRSVFLLPLEFHSGSSYELQVRAGPQPGSTFQGTWSEWSDPVVFHTQPEERKGDLYLHLVPIPLILVCLIFVFLGLKVPWRPWEKVWLQVSSPKPFFQPLYVGHSGDFKKWVGTPFTASSLELRPWSPGVHLALEMCSPCPPQGVVKGLVPTELPEPTDLVEADGVPEPGSWGPVPSTAGSLGSSVYSQEKDRLYGLVSIDTVTVVDAEGLCGWPCTCGDDGYPALNLDTGLEPGPDTEDRLLSTGTTILSCGCVSAGGPMRPGSLLDRLRLSHEDEADWTPGPSDSEAGSPPVGLDMNTFDSGFADSDCGSPVESDFSSPRDEEPPRSYLRQWVVMAPPPTPPGSQAS", "length": 531, "header": "tr|E1BBE5-1|E1BBE5_BOVIN Isoform 1 of Interleukin 21 receptor OS=Bos taurus OX=9913 GN=IL21R PE=4 SV=1 CANONICAL=E1BBE5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z6/entry", "sequence": { "sequence": "MPCAWAATLLLLMLQGTWGCSNLVCYTDYIETITCILDTWARHPDSLTLTWHDTYGELEDEVTSCSLLRSTHNATHVEYTCHMNVFRLMADDFFNVSMTDPSGNYSQECGSFIVAASIKPSPPFNVTVNFSGYYNVSWSSSSSFSPSDRVYALKDKLQYELRYRKVGEPWAQSPGRKLISEDSRSVFLLPLEFHSGSSYELQVRAGPQPGSTFQGTWSEWSDPVVFHTQPEERKGDLYLHLVPIPLILVCLIFVFLGLKVPWRPWEKVWLQVSSPKPFFQPLYVGHSGDFKKWVGTPFTASSLELRPWSPGVHLALEMCSPCPPQGVVKGLVPTELPEPTDLVEADGVPEPGSWGPVPSTAGSLGSSVYSQEKDRLYGLVSIDTVTVVDAEGLCGWPCTCGDDGYPALNLDTGLEPGPDTEDRLLSTGTTILSCGCVSAGGPMRPGSLLDRLRLSHEDEADWTPGPSDSEAGSPPVGLDMNTFDSGFADSDCGSPVESDFSSPRDEEPPRSYLRQRILGHLGSPNKL", "length": 527, "header": "tr|A0A3Q1M1Z6-1|E1BBE5_BOVIN Computationally mapped isoform of Interleukin 21 receptor OS=Bos taurus OX=9913 GN=IL21R PE=4 SV=1 CANONICAL=E1BBE5-1" }, "locus": { "chromosome": "25", "start_pos": 25006357, "end_pos": 24987052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080914.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080914.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064004.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064004.2" } ] } }, { "isoform_ac": "E1BBE5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBE5/entry", "sequence": { "sequence": "MPCAWAATLLLLMLQGTWGCSNLVCYTDYIETITCILDTWARHPDSLTLTWHDTYGELEDEVTSCSLLRSTHNATHVEYTCHMNVFRLMADDFFNVSMTDPSGNYSQECGSFIVAASIKPSPPFNVTVNFSGYYNVSWSSSSSFSPSDRVYALKDKLQYELRYRKVGEPWAQSPGRKLISEDSRSVFLLPLEFHSGSSYELQVRAGPQPGSTFQGTWSEWSDPVVFHTQPEERKGDLYLHLVPIPLILVCLIFVFLGLKVPWRPWEKVWLQVSSPKPFFQPLYVGHSGDFKKWVGTPFTASSLELRPWSPGVHLALEMCSPCPPQGVVKGLVPTELPEPTDLVEADGVPEPGSWGPVPSTAGSLGSSVYSQEKDRLYGLVSIDTVTVVDAEGLCGWPCTCGDDGYPALNLDTGLEPGPDTEDRLLSTGTTILSCGCVSAGGPMRPGSLLDRLRLSHEDEADWTPGPSDSEAGSPPVGLDMNTFDSGFADSDCGSPVESDFSSPRDEEPPRSYLRQWVVMAPPPTPPGSQAS", "length": 531, "header": "tr|E1BBE5-1|E1BBE5_BOVIN Isoform 1 of Interleukin 21 receptor OS=Bos taurus OX=9913 GN=IL21R PE=4 SV=1 CANONICAL=E1BBE5-1" }, "locus": { "chromosome": "25", "start_pos": 25001495, "end_pos": 24987052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026072.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026072.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026072.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026072.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 524, "start_aa": "Thr", "end_pos": 524, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr524", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617967", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617967", "resource": "KEGG Pathway" }, { "id": "R-BTA-9020958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020958", "resource": "Reactome", "description": "Interleukin-21 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AE50-1", "protein_name": "Interleukin 21 receptor", "gene_name": "IL21R", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLCGWAAPLLLLLLQGAWGCSDLVCYTDYLHTVTCVLETWTLHPSALTLTWQDLYGEMEEEVTSCSLRLSTRNATHAEYTCHMDVFQFMADDIFSINMTDQSGNHSQECGSFVLANSIKPSPPFNVTVTFSGHYNISWSSDYNVFALKGKLQYELRYRKLGDPWAQSPGRKLISVDSRSVSLLPLEFHKGSSYELQLRAGPQPDSSFQGTWSEWSDPVIFHTQPEEMKRNWYPHLLLILILVCPVLVFLGLKIHLPWRLWKKVWVQVPSPEPFFQPLYVGHSGDFKRWVGTPFPPSSLELRSWSVGVPSILEMHSQCPAQRAAKGLAPMELPEPADLVEADGVPEPGSWDPAPSTASTLGGSAYSQERDRPYGKLSIETVTVRDAEGPCAWPCTCGDDDSYPALNLEPGSGTEDPLLDPEATFLSCGCVSARGSVGLGGPAGSVLARVKPSPEDEAGWAPGPPWGDGPPRGVSDSEAGSPPAGLDMDTFDSGFADSDCGSPVECDFSSPRDEGPPRSYLRQWVVMSPPLAESGPQAS", "length": 537 }, "evidence": [ { "id": "E1BBE5", "url": "https://omabrowser.org/oma/group/E1BBE5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3Q2UB88-1", "protein_name": "Interleukin 21 receptor", "gene_name": "IL21R", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLQCEEASHLQGTVPMGQLGHPVRTKMRNKLWLQSISFFLLFQYSTCHENLTCFVDYVQTLSCLLRNDLGASPYNITATWVDEDDPENTVAACSLLELSRNANHTEYVCTVDMTELLADIRVQVDATEIADRQHVISIGFYMKDNIRPQPPFNLTAVFTEGYNISWETIHQNPLFYLLNGELEYQLRYKRRADTWETQKIKSVPEDKRTVVILPQEFQGNTEYEFQVRARPRGGTGYFGFWSEWSSRLTLKTSPAAVTQRAGMGWMLFFVVAMVITASITAFLAKQQSLWKKIACIPDPSAFFKPLYLMYNGDFKKWVGTSHMKMTIDLFEWEIVPSEVLEVFSMRPSNCTSQEEIRELKNDLPCKPCVSCLTTPVQDSLLSSVNSSSVTPDRSYGHLSIDTVTVADEFTPCNCQCNCNRMYKEQKHNGDEDSAEESGYPKVNIDDEDRRPSSALHLSDLSSQDKILASGSMSTDHLRTTGAPGHQKVEGALEGGMGSILEALCLHPNQWDLENPASLPSPDGESVSYSEGSCDFFPRGARPGGSYPMICLDLDTIDSGFVDSDCGSPVDFEFEQNSQTNAESVPLEQEGEDFPRSYVKQWISCHADSPASGTQTD", "length": 616 }, "evidence": [ { "id": "E1BBE5", "url": "https://omabrowser.org/oma/group/E1BBE5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9HBE5-1", "protein_name": "Interleukin-21 receptor", "gene_name": "IL21R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS", "length": 538 }, "evidence": [ { "id": "E1BBE5", "url": "https://omabrowser.org/oma/group/E1BBE5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JHX3-1", "protein_name": "Interleukin-21 receptor", "gene_name": "Il21r", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRGPVAALLLLILHGAWSCLDLTCYTDYLWTITCVLETRSPNPSILSLTWQDEYEELQDQETFCSLHRSGHNTTHIWYTCHMRLSQFLSDEVFIVNVTDQSGNNSQECGSFVLAESIKPAPPLNVTVAFSGRYDISWDSAYDEPSNYVLRGKLQYELQYRNLRDPYAVRPVTKLISVDSRNVSLLPEEFHKDSSYQLQVRAAPQPGTSFRGTWSEWSDPVIFQTQAGEPEAGWDPHMLLLLAVLIIVLVFMGLKIHLPWRLWKKIWAPVPTPESFFQPLYREHSGNFKKWVNTPFTASSIELVPQSSTTTSALHLSLYPAKEKKFPGLPGLEEQLECDGMSEPGHWCIIPLAAGQAVSAYSEERDRPYGLVSIDTVTVGDAEGLCVWPCSCEDDGYPAMNLDAGRESGPNSEDLLLVTDPAFLSCGCVSGSGLRLGGSPGSLLDRLRLSFAKEGDWTADPTWRTGSPGGGSESEAGSPPGLDMDTFDSGFAGSDCGSPVETDEGPPRSYLRQWVVRTPPPVDSGAQSS", "length": 529 }, "evidence": [ { "id": "E1BBE5", "url": "https://omabrowser.org/oma/group/E1BBE5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BBE5", "url": "https://www.uniprot.org/uniprotkb/E1BBE5" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BBE5", "url": "https://www.uniprot.org/uniprotkb/E1BBE5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "E1BBE5", "url": "https://www.uniprot.org/uniprotkb/E1BBE5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "E1BBE5", "url": "https://www.uniprot.org/uniprotkb/E1BBE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBE5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 531, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBE5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBE5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 524 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 125, "end_pos": 127 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 135, "end_pos": 137 }, { "start_pos": 73, "end_pos": 75 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A4FUB0-1", "uniprot_ac": "A4FUB0", "uniprot_id": "CE034_BOVIN", "mass": { "chemical_mass": 72812.0, "monoisotopic_mass": 72812.0 }, "refseq": { "ac": "NP_001076895", "name": "uncharacterized protein C5orf34 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076895" }, "gene_names": [ { "name": "C20H5orf34", "type": "recommended", "evidence": [ { "id": "A4FUB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUB0" } ] }, { "name": "C20H5orf34", "type": "synonym", "evidence": [ { "id": "NP_001076895", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076895" } ] }, { "name": "C5orf34", "type": "synonym", "evidence": [ { "id": "NP_001076895", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076895" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C5orf34 homolog", "type": "recommended", "evidence": [ { "id": "A4FUB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUB0/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C5orf34 homolog", "type": "synonym", "evidence": [ { "id": "NP_001076895", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076895" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A4FUB0", "url": "https://www.uniprot.org/uniprotkb/A4FUB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A4FUB0", "locus": {} } ], "crossref": [ { "id": "A4FUB0", "url": "https://alphafold.ebi.ac.uk/entry/A4FUB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514072", "url": "https://www.ncbi.nlm.nih.gov/gene/514072", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514072", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514072", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TAVISWC", "url": "https://omabrowser.org/oma/group/TAVISWC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M213", "url": "https://www.orthodb.org/?gene=A0A3Q1M213", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MV26", "url": "https://www.orthodb.org/?gene=A0A3Q1MV26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A4FUB0", "url": "https://www.orthodb.org/?gene=A4FUB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34531", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34531", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34531:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34531:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15016", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15016", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22834", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22834", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001076895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076895", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M213", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M213", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M213-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M213-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV26", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV26-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4FUB0", "url": "https://www.uniprot.org/uniprotkb/A4FUB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4FUB0-1", "url": "https://www.uniprot.org/uniprotkb/A4FUB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEVQMVLYEDDSVQVQYIDGSRLQLSPCGSEFLFEKAPPVSAHPLQQPERIRQRTHFVISAYREQLQRALDFRNSFATCPFLSESIIPSEMKTRILIDVSEVRWPSLDTGDGMTYMQSGTVRISSLDGHAYLCLPKSQHEFTVHFLCKVSQKPDSSIEVSEKNNKGKKDKQVEKAGKICTRGSLSGQRLKNKENELYHQIMKSEEPSEKSCVNGAKGREVLSSPHPKDTCIYTWVKQCWSVASCPEEWKYPLSLALHFHDKISSMSGIDADITQKRMLTSDVSEERGKEVSVLPRALLLSCPAPHLHRWNFSDSLSQKQFGEEEYSYHELVKVVWYKGVTYRLTHKHMNSIEIYPGDGSVFKSEGAYLGNYFTYYSIREESEEREEKTYAVNNLPPDRPGSPFSVCSLIKQATRILQHCAKMRLSLSHNYRVCCWKMVPGINDSSVLPLLLRESFVPGVGRFLAYSDDKVHAIFLDGITLTLNWNFGSFIEKRQVNRGLTLGWCKLTFPDGQNQLIQIQHPRPYERYVTTVISWCRRLTQISQQEIPIHPSSSVPEESWSVASELEKIQKFNLLLESSGVLNQTSNKKNKQSLDRCKPKSSETLLKEVNEKSVSVALKKTSEILQDIDNLLSNSKW", "length": 638, "header": "sp|A4FUB0-1|CE034_BOVIN Isoform 1 of Uncharacterized protein C5orf34 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A4FUB0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M213-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M213/entry", "sequence": { "sequence": "MAAEVQMVLYEDDSVQVQYIDGSRLQLSPCGSEFLFEKAPPVSAHPLQQPERIRQRTHFVISAYREQLQRALDFRNSFATCPFLSESIIPSEMKTRILIDVSEVRWPSLDTGDGMTYMQSGTVRISSLDGHAYLCLPKSQHEFTVHFLCKVSQKPDSSIEVSEKNNKGKKDKQVEKAGKICTRGSLSGQRLKNKENELYHQIMKSEEPSEKSCVNGAKGREVLSSPHPKDTCIYTWVKQCWSVASCPEEWKYPLSLALHFHDKISSMSGIDADITQKRMLTSDVSEERGKEVSVLPRALLLSCPAPHLHRWNFSDSLSQKQFGEEEYSYHELVKVVWYKGVTYRLTHKHMNSIEIYPGDGSVFKSEGAYLGNYFTYYSIREESEEREEKTYAVNNLPPDRPGSPFSVCSLIKQATRILQHCAKMRLSLSHNYRVCCWKMVPGINDSSVLPLLLRESFVPGVGRFLAYSDDKVHAIFLDGITLTLNWNFGSFIEKRQVNRGLTLGWCKLTFPDGQNQLIQIQHPRPYERYVTTVISWCRRLTQISQQEIPIHPSSSVPEESWSVASELEKIQKFNSLK", "length": 577, "header": "tr|A0A3Q1M213-1|CE034_BOVIN Computationally mapped isoform of Uncharacterized protein C5orf34 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A4FUB0-1" }, "locus": { "chromosome": "20", "start_pos": 31329803, "end_pos": 31304261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070891.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070891.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064024.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064024.2" } ] } }, { "isoform_ac": "A0A3Q1MV26-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV26/entry", "sequence": { "sequence": "MAAEVQMVLYEDDSVQVQYIDGSRLQLSPCGSEFLFEKAPPVSAHPLQQPERIRQRTHFVISAYREQLQRALDFRNSFATCPFLSESIIPSEMKTRILIDVSEVRWPSLDTGDGMTYMQSGTVRISSLDGHAYLCLPKSQHEFTVHFLCKVSQKPDSSIEVSEKNNKGKKDKQVEKAGKICTRGSLSGQRLKNKENELYHQIMKSEEPSEKSCVNGAKGREVLSSPHPKDTCIYTWVKQCWSVASCPEEWKYPLSLALHFHDKISSMSGIDADITQKRMLTSDVSEERGKEVSVLPRALLLSCPAPHLHRWNFSDSLSQKQFGEEEYSYHELVKVVWYKGVTYRLTHKHMNSIEIYPGDGSVFKSEGAYLGNYFTYYSIREESEEREEKTYAVNNLPPDRPGSPFSVCSLIKQATRILQHCAKMRLSLSHNYRVCCWKMVPGINDSSVLPLLLRESFVPGVGRFLAYSDDKVHAIFLDGITLTLNWNFGSFIEKRQVNRGLTLGWCKLTFPDGQNQLIQIQHPRPYERYVTTVISWCRRLTQISQQEIPIHPSSSVPEESWSVASELEKIQKFNLLLESSGVLNQTSNKKNKQSLDRCKPKSSETLLKEVNEKSVSVALKKTSEILQDIDNLLSNSK", "length": 637, "header": "tr|A0A3Q1MV26-1|CE034_BOVIN Computationally mapped isoform of Uncharacterized protein C5orf34 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A4FUB0-1" }, "locus": { "chromosome": "20", "start_pos": 31330856, "end_pos": 31304261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082919.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082919.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058741.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058741.2" } ] } }, { "isoform_ac": "A0AAA9S7G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G9/entry", "sequence": { "sequence": "MAAEVQMVLYEDDSVQVQYIDGSRLQLSPCGSEFLFEKAPPVSAHPLQQPERIRQRTHFVISAYRRILIDVSEVRWPSLDTGDGMTYMQSGTVRISSLDGHAYLCLPKSQHEFTVHFLCKVSQKPDSSIEVSEKNNKGKKDKQVEKAGKICTRGSLSGQRLKNKENELYHQIMKSEEPSEKSCVNGAKGREVLSSPHPKDTCIYTWVKQCWSVASCPEEWKYPLSLALHFHDKISSMSGIDADITQKRMLTSDVSEERGKEVSVLPRALLLSCPAPHLHRWNFSDSLSQKQFGEEEYSYHELVKVVWYKGVTYRLTHKHMNSIEIYPGDGSVFKSEGAYLGNYFTYYSIREESEEREEKTYAVNNLPPDRPGSPFSVCSLIKQATRILQHCAKMRLSLSHNYRVCCWKMVPGINDSSVLPLLLRESFVPGVGRFLAYSDDKVHAIFLDGITLTLNWNFGSFIEKRQVNRGLTLGWCKLTFPDGQNQLIQIQHPRPYERYVTTVISWCRRLTQISQQEIPIHPSSSVPEESWSVASELEKIQKFNLLLESSGVLNQTSNKKNKQSLDRCKPKSSETLLKEVNEKSVSVALKKTSEILQDIDNLLSNSKW", "length": 608, "header": "tr|A0AAA9S7G9-1|CE034_BOVIN Computationally mapped isoform of Uncharacterized protein C5orf34 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A4FUB0-1" }, "locus": { "chromosome": "20", "start_pos": 31330857, "end_pos": 31304261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098802.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098802.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081179.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081179.1" } ] } }, { "isoform_ac": "A4FUB0-1", "url": "https://www.uniprot.org/uniprotkb/A4FUB0/entry#A4FUB0-1", "sequence": { "sequence": "MAAEVQMVLYEDDSVQVQYIDGSRLQLSPCGSEFLFEKAPPVSAHPLQQPERIRQRTHFVISAYREQLQRALDFRNSFATCPFLSESIIPSEMKTRILIDVSEVRWPSLDTGDGMTYMQSGTVRISSLDGHAYLCLPKSQHEFTVHFLCKVSQKPDSSIEVSEKNNKGKKDKQVEKAGKICTRGSLSGQRLKNKENELYHQIMKSEEPSEKSCVNGAKGREVLSSPHPKDTCIYTWVKQCWSVASCPEEWKYPLSLALHFHDKISSMSGIDADITQKRMLTSDVSEERGKEVSVLPRALLLSCPAPHLHRWNFSDSLSQKQFGEEEYSYHELVKVVWYKGVTYRLTHKHMNSIEIYPGDGSVFKSEGAYLGNYFTYYSIREESEEREEKTYAVNNLPPDRPGSPFSVCSLIKQATRILQHCAKMRLSLSHNYRVCCWKMVPGINDSSVLPLLLRESFVPGVGRFLAYSDDKVHAIFLDGITLTLNWNFGSFIEKRQVNRGLTLGWCKLTFPDGQNQLIQIQHPRPYERYVTTVISWCRRLTQISQQEIPIHPSSSVPEESWSVASELEKIQKFNLLLESSGVLNQTSNKKNKQSLDRCKPKSSETLLKEVNEKSVSVALKKTSEILQDIDNLLSNSKW", "length": 638, "header": "sp|A4FUB0-1|CE034_BOVIN Isoform 1 of Uncharacterized protein C5orf34 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A4FUB0-1" }, "locus": { "chromosome": "20", "start_pos": 31330857, "end_pos": 31304261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009815.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009815.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009815.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009815.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514072", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514072", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YQS1-1", "protein_name": "Chromosome 5 open reading frame 34", "gene_name": "C5orf34", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAERLMVLYGDDSVEVHYADGARLLLSPCGSEYLYEEALPAAAHPLQPAESTRQRVPFVLSAYREQILRALDFRNTFSSRPYLPSRIISPERKRIIFSDIVEVRWPDPVSADLTRCIKNGSVKISSVDGYAHLYLSELQQEFTVEFLCKVSQPFAKSANQPSHFSPKNSNYETEDQYGKSSKNSVPEMSSKQVRIDNKNNEDGHAEGKYREATKPNNQRDRGGVPLFYTNCTSEYTWVTQRWSVSSCPEEWKYPLSLALMCHSLHTAKNVLKTCEENDRTSIGADVSTDPKTYEAVSRLPAALPVSCRAPHLHRWSFCDFFLQRNEDSEQYSYPQLIQIVWCEGVFYRFIHGRRNITEIYPGDESLLKSEGDFLGNYFVHYAIQKGIKKREEKMYSVNSLPPDVPGSQYSVSSIITAATKMLQYCYKTKLSLIHNYHLCCWKMVPETDGREMLPVLLYEKVIHGTGRLLVYSDHKVHAAFWDGISLNMVWDFSSCYKKIQVNEDVGWCKLTTPDGVQQLIQIRHPGIYERYIRTVIGWCRSLNESKETPELTTHTVTEENWCADAELEKIQRFNFLLDNSNVLEGTSAAKNNLSIRKTESGSGPEEMSEGHVLEALQNTSRIIQDIESLLASAGK", "length": 636 }, "evidence": [ { "id": "A4FUB0", "url": "https://omabrowser.org/oma/group/A4FUB0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3UJC8-1", "protein_name": "Uncharacterized protein C5orf34 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGMAAEVRMVLYEDDSVQVHYACGSTLQLSPCGSEFLFEKALPPSTHPLEQPERIRQRTHFVISNYREQLQRALDFRNSSATCPFLSESIIPPERKKHIFIDFSEVEWPSLDRDDCIMYSESGVVKITSLDGHAYLCLPRSQHEFTVHFLCKVSQRPDSSGILSETQNQDPKNKLVEKTRKVCRCGNLSEQTLRNKENEPPYQILKSKNASVNTCCVNDSEGRGELPSLGTNHRCVYAWVKQAWSVAACPEAWKHPLSLALRFYNKVRAASEIDADFPASSIVTSDCPEERGTEVSVLPRALLLSCPAPHMHRWTFCDSLLQRQPDAEDFSYPELVKVVWYKGVTYRLTHKNVNSIEIFPGDGSVFKSEGAHFGNYFTYYPSQEESEKREEKTYSVNNLPPDRPGNFFSVRSLIKQATRILQHCAKIRLSLSHNYRVCCWKMAPGVSVSTILPVLLKESLIPGVGRFLAYSDDKVHAVFLDGVTVTLNWHLSSSAEKKQVDQGLSFGWCRLTFPDGQDQLIPTEHPGAYERYVTSVISWCRGLTQTSPRQVPTHLSPALKENWSVASELEKIQKFNWLLENSGVLNLTSSKNEQCSGHCKSGSSETLLEATNEERVSVALKRTSEILQDIDRLLSLSRK", "length": 639 }, "evidence": [ { "id": "A4FUB0", "url": "https://omabrowser.org/oma/group/A4FUB0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYM1-1", "protein_name": "Uncharacterized protein C5orf34 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTAAEVRMVLYEDDSVQVNYADGSTLQLSPCGSEFLFEKAPPPSTHPLEQPERIRQRTHFVISNYREQLQRALDFRNSSATCPFLSESIIPSERKKRVFIDFSEVEWPSPDRDDCITYSESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVSQKPDSSVMPPETKNRVPKEELVGKTRNVCRSGRLSGQRLRNKENEPPRQLLTSKNASANIHCVSETEGREELPSPGTKRRYVHVWVKQSWSAASCPEEWKYPLSLGLRFYNKVPAASAADAEVPVSGIVTSDNPEERGTGVSVLPRALLLSCSAPHMHRWNFCDSLLQRQSDAEEYSYPELIKVVWYKGVTYRLTHKNVNSIEIFPGDGSVFKSEGTHFGNYFTYSSQDNSGKREEKTYSVNNLPPDRPGNLYSVRSLIKQATRILQHCAKIRLSLSHNYRVCCWRMAPGVNVSSILPVLLKESLIPGVGRFLAYSDDKVHAVFLDGVTLTLNWDLSSSAEKTQVDQGLRLRWCRLTFPDGQDQLIQTEHPGVYERYVTSVVTWCRRLTQTSSRHVSPRLSPVPEENWSVASELEKIQKFNWLLENSGVLNLTSGKKNEQCSSDHCKPGSSETLPEATNEESVSVALKRTSEVLQDIDYLLSLTRK", "length": 640 }, "evidence": [ { "id": "A4FUB0", "url": "https://omabrowser.org/oma/group/A4FUB0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96MH7-1", "protein_name": "Uncharacterized protein C5orf34", "gene_name": "C5orf34", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAELRMILYEDDSVQVQYVDGSTLQLSPCGSEFLFEKSPPVSAHPLEQPERIRQRTHFVISTYREQLQRALDFRNSSATCPFLSETIIPSERKKHIFIDITEVRWPSLDTDGTMIYMESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVSQKSDSSAVLSETNNKAPKDKLVEKTGKICIRGNLPGQRLKNKENEFHCQIMKSKETLKKMSCVNGTEGREELPSPGTKHTCVYTWVKQCWSVAACPEEWKYPLSLALHFHNKISNMSKIDAHITQSRFLTSDISEERGKVVSVLPRALSLSCPVPHLHRWNFCDSLLQRQSDEYSYPELVKMVWYKGVTYRLTHQNMNSIEIYSGDGSVFKSEGAYFGNYFTYYSIQEGSGKREEKTYSVNNLPPDRPGSPFTVGSLIKQATRILQHCVKMRLSLSHNYRICCWKMVPGINDSNILPLVLKESLIPSVGRFLAYSDDKVHAIFLDGITLTLNWNFSSPIEKRQVNQGLNLGWCKLTFPDGQEQLIQIEHPEPYERYVTTVTSWCRRLTQTSPREMPTHSSSSVLQENWSVASELEKIQKFNLLLENSGILNQISNKKNEQQSFDHYKPGSSETLLGEVNENRVSIALKKTSEILHDIDCLLSNSKK", "length": 638 }, "evidence": [ { "id": "A4FUB0", "url": "https://omabrowser.org/oma/group/A4FUB0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 584, "end_pos": 586, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A4FUB0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 638, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A4FUB0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A4FUB0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 312, "end_pos": 314 }, { "start_pos": 444, "end_pos": 446 }, { "start_pos": 584, "end_pos": 586 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QQ68-1", "uniprot_ac": "A6QQ68", "uniprot_id": "F228B_BOVIN", "mass": { "chemical_mass": 31760.0, "monoisotopic_mass": 31760.0 }, "refseq": { "ac": "NP_001098965", "name": "protein FAM228B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098965" }, "gene_names": [ { "name": "FAM228B", "type": "recommended", "evidence": [ { "id": "A6QQ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ68" } ] }, { "name": "FAM228B", "type": "synonym", "evidence": [ { "id": "NP_001098965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098965" } ] } ], "protein_names": [ { "name": "Protein FAM228B", "type": "recommended", "evidence": [ { "id": "A6QQ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ68/entry#names_and_taxonomy" } ] }, { "name": "UPF0638 protein B", "type": "synonym", "evidence": [ { "id": "NP_001098965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098965" } ] }, { "name": "protein FAM228B", "type": "synonym", "evidence": [ { "id": "NP_001098965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098965" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQ68", "url": "https://www.uniprot.org/uniprotkb/A6QQ68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM228B", "url": "https://www.uniprot.org/uniprotkb/A6QQ68", "locus": { "chromosome": "11", "start_pos": 74947565, "end_pos": 74990076, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030864", "url": "https://www.ensembl.org/id/ENSBTAG00000030864" } ] } } ], "crossref": [ { "id": "A6QQ68", "url": "https://alphafold.ebi.ac.uk/entry/A6QQ68", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030864", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030864", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100125925", "url": "https://www.ncbi.nlm.nih.gov/gene/100125925", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100125925", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125925", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KVCSYKK", "url": "https://omabrowser.org/oma/group/KVCSYKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2B8", "url": "https://www.orthodb.org/?gene=A0A3Q1M2B8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QQ68", "url": "https://www.orthodb.org/?gene=A6QQ68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28584", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28584", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28584:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28584:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098965", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2B8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDJ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ68", "url": "https://www.uniprot.org/uniprotkb/A6QQ68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ68-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSYENDPITDKLPKLKSSREWLEPQPLSFMEVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 264, "header": "sp|A6QQ68-1|F228B_BOVIN Isoform 1 of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B8/entry", "sequence": { "sequence": "MLFTKEANFLVFLGNLLFGATMKSYENDPITDKLPKLKSSREWLEPQPLSFMEELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 262, "header": "tr|A0A3Q1M2B8-1|F228B_BOVIN Computationally mapped isoform of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "locus": { "chromosome": "11", "start_pos": 74973391, "end_pos": 74947857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066406.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066406.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063918.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063918.1" } ] } }, { "isoform_ac": "A0AAA9SDJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ9/entry", "sequence": { "sequence": "AFLQEGYPSYIFFIRPIFQKHLSAIVPPRHLCQNHYCKKRDGRSPTVYSEGRSKRPKEAFSGNFVVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 297, "header": "tr|A0AAA9SDJ9-1|F228B_BOVIN Computationally mapped isoform of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "locus": { "chromosome": "11", "start_pos": 74982270, "end_pos": 74947857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101892.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101892.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081902.1" } ] } }, { "isoform_ac": "A0AAA9SVM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM8/entry", "sequence": { "sequence": "SHTRKHLSAIVPPRHLCQNHYCKKRDGRSPTVYSEGRSKRPKEAFSGNFVVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 282, "header": "tr|A0AAA9SVM8-1|F228B_BOVIN Computationally mapped isoform of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "locus": { "chromosome": "11", "start_pos": 74989142, "end_pos": 74947857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111965.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111965.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087237.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087237.1" } ] } }, { "isoform_ac": "A0AAA9TQ67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ67/entry", "sequence": { "sequence": "MSEPGIKLSHGPAQGSRVEGKTAWGNHLSHQLQTPLLFIYIPLLSILARRLPKLHIFYKAYFPETPVSHCPSSSSVSKPLLQEKGRKKPNSVFRGKVQKAKGGLFWKLCVFLGNLLFGATMKSYENDPITDKLPKLKSSREWLEPQPLSFMEVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 384, "header": "tr|A0AAA9TQ67-1|F228B_BOVIN Computationally mapped isoform of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "locus": { "chromosome": "11", "start_pos": 74982403, "end_pos": 74947857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099169.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099169.1" } ] } }, { "isoform_ac": "A0AAA9TXX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXX6/entry", "sequence": { "sequence": "RKSKALPALNRKGRDLGLRSVPVGETLNQGSCLDGARPEESSAGRKRASLGGSAPWPIFQKHLSAIVPPRHLCQNHYCKKRDGRSPTVYSEGRSKRPKEAFSGNFVVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 338, "header": "tr|A0AAA9TXX6-1|F228B_BOVIN Computationally mapped isoform of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "locus": { "chromosome": "11", "start_pos": 74990074, "end_pos": 74947857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109801.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109801.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102344.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102344.1" } ] } }, { "isoform_ac": "A6QQ68-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ68/entry#A6QQ68-1", "sequence": { "sequence": "MKSYENDPITDKLPKLKSSREWLEPQPLSFMEVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF", "length": 264, "header": "sp|A6QQ68-1|F228B_BOVIN Isoform 1 of Protein FAM228B OS=Bos taurus OX=9913 GN=FAM228B PE=2 SV=1 CANONICAL=A6QQ68-1" }, "locus": { "chromosome": "11", "start_pos": 74973328, "end_pos": 74947857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043656.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043656.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041212.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041212.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100125925", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125925", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U276-1", "protein_name": "Uncharacterized protein", "gene_name": "FAM228", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNVRPLLYWKPVLRGELRSSSTINASPQAMRTADSSETIPQATSSPPAAELSQQKLCQRYPTAPARSNTANTFDCSRFFGKTNTSRFWLTQKDFYHVKAAPDESTDIITSAQSILDRENYFVKEVDRYLRHHDFLNLRKKEILYKKWLEDVSEPLLWKIEDKMDSQSREEIQKRREEQLSLYLNYCKKKGYVALEAYDPSEYDPLFLKTCTDCWKVSIPALQDPLLKTVQKKFIETSIIKQCETGRPCSTRELQKLPLLPLGRQHMDAIEWLKVPYTYIASELHRTRRLRVVDHHKDSENR", "length": 301 }, "evidence": [ { "id": "A6QQ68", "url": "https://omabrowser.org/oma/group/A6QQ68/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "M0R8F7-1", "protein_name": "Family with sequence similarity 228, member B", "gene_name": "Fam228b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKNRNPDDTVTDTFPKLKSSKEWLEPQSLSFMEALAKEDTDAAVQSILYRENYIMKELDKYLHHYDFLNTRRKEMLYKKWVERVADPLQKKIIEKVGSHKNIKKRRRQELDNFLKHSNKKGNAFIEHYDPKEYDPFYMSKEDPNFLKVVLPPFRDPLKKAQYDKDDEKRTLLQCETGKIYTMKEFKEIEKAQLHSRFPSISNSRQSMTPNKWLKVPMSYIESEFCKRSRFKVKMNFNASSFDLRPLKRVPNFLEYREEEMMIIYKL", "length": 266 }, "evidence": [ { "id": "A6QQ68", "url": "https://omabrowser.org/oma/group/A6QQ68/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C875-1", "protein_name": "Protein FAM228B", "gene_name": "FAM228B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKNVDSDDLVTGTLPKLKSSKEWLEPKPLCFMEVLAKEDTEAAIQSILYKENSVIKELDKYLQHHAFLNARRKEMLYKRWVDCVADPLQKKIIEKVCSHKKIKKRRQGELDGFLKHVNKKGNAFIEHYDPKEYDPFYMSKKDPNFLKVTIPPFHDPLKKAQYDKDNEKRTLLQCETGKIYSIKEFKEVEKVQLHSRFPQISNSRHFITPNEWLKLPTRYIESEFCRRRRLKVKVNFNDCSFDLKPLARAPYLLESQEEEKTVIYKNKGSSFLEREPLCYQEGNNPSAKEAISEGYFSSLSLSQEREEDQDGSPSPRLGLLKLEL", "length": 324 }, "evidence": [ { "id": "A6QQ68", "url": "https://omabrowser.org/oma/group/A6QQ68/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q497Q6-1", "protein_name": "Protein FAM228B", "gene_name": "Fam228b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTMKNRSQDDMVTGTLPKLKSSKEWLEPQSLSFMEALAKEDTDAAVQSILYRENYIMKELDKYLHHQDFLNTRRKEMLYKKWVERVADPLQKKIIEKVHSHKNIKKRRRQELDNFLKHSNKKGNAFIEHYDPKEYDPFYMSKEDPNFLKVIMPPFRDPLKKAQYDQDDEKRTLLQCETGKIYTMKEFKEIEKAQLHSRFPSISNSRQSMTPNGWLKVPMSYIESEFCKKSR", "length": 232 }, "evidence": [ { "id": "A6QQ68", "url": "https://omabrowser.org/oma/group/A6QQ68/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQ68-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQ68-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQ68" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 236, "end_pos": 238 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QQ66-1", "uniprot_ac": "A6QQ66", "uniprot_id": "ERIC2_BOVIN", "mass": { "chemical_mass": 16239.0, "monoisotopic_mass": 16239.0 }, "refseq": { "ac": "NP_001095756", "name": "glutamate-rich protein 2 isoform 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095756" }, "gene_names": [ { "name": "ERICH2", "type": "recommended", "evidence": [ { "id": "A6QQ66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ66" } ] }, { "name": "ERICH2", "type": "synonym", "evidence": [ { "id": "NP_001095756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095756" } ] } ], "protein_names": [ { "name": "Glutamate-rich protein 2", "type": "recommended", "evidence": [ { "id": "A6QQ66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ66/entry#names_and_taxonomy" } ] }, { "name": "glutamate-rich protein 2 isoform 4", "type": "synonym", "evidence": [ { "id": "NP_001095756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095756" } ] }, { "name": "glutamate-rich protein 2", "type": "synonym", "evidence": [ { "id": "NP_001095756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095756" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQ66", "url": "https://www.uniprot.org/uniprotkb/A6QQ66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ERICH2", "url": "https://www.uniprot.org/uniprotkb/A6QQ66", "locus": { "chromosome": "2", "start_pos": 25661936, "end_pos": 25694212, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051169", "url": "https://www.ensembl.org/id/ENSBTAG00000051169" } ] } } ], "crossref": [ { "id": "A6QQ66", "url": "https://alphafold.ebi.ac.uk/entry/A6QQ66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615113", "url": "https://www.ncbi.nlm.nih.gov/gene/615113", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615113", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615113", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DEESFCN", "url": "https://omabrowser.org/oma/group/DEESFCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3B8", "url": "https://www.orthodb.org/?gene=A0A3Q1M3B8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUQ2", "url": "https://www.orthodb.org/?gene=A0A3Q1MUQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QQ66", "url": "https://www.orthodb.org/?gene=A6QQ66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21520", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21520", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21520:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21520:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001095756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095756", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3B8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUQ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5X1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ66", "url": "https://www.uniprot.org/uniprotkb/A6QQ66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ66-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 142, "header": "sp|A6QQ66-1|ERIC2_BOVIN Isoform 1 of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=1 CANONICAL=A6QQ66-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3B8/entry", "sequence": { "sequence": "MSTLPMLRVRGPQAGKRRRTERGRRLPISASNLTQFLPRTPSGPALEPANFSDRSRFGLWRPTTAQAAHEKESSRQDICCKEKVMIEPNEGMSEKEVSSKNIKNKISSNNTKNRISSKSISNKQIETNLQSKLWSSSFLKASTGEMSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 287, "header": "tr|A0A3Q1M3B8-1|ERIC2_BOVIN Computationally mapped isoform of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=2 CANONICAL=A6QQ66-1" }, "locus": { "chromosome": "2", "start_pos": 25694077, "end_pos": 25661993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081311.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081311.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067989.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067989.2" } ] } }, { "isoform_ac": "A0A3Q1MUQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUQ2/entry", "sequence": { "sequence": "MSTLPMLRVRGPQAGKRRRTERGRRLPISASNLTQFLPRTPSGPALEPANFSDRSRFGLWRPTTAQAAHEKEVSSKNIKNKISSNNTKNRISSKSISNKQIETNLQSKLWSSSFLKASTGEMSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 263, "header": "tr|A0A3Q1MUQ2-1|ERIC2_BOVIN Computationally mapped isoform of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=2 CANONICAL=A6QQ66-1" }, "locus": { "chromosome": "2", "start_pos": 25694077, "end_pos": 25661993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077251.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077251.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074356.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074356.2" } ] } }, { "isoform_ac": "A0AAA9TUM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM3/entry", "sequence": { "sequence": "MIEPNEGMSDPAFHMMYSAHKLNNRVTIYSLDVLLSQFGTNQSVVPCPVLLLLLDLHTDFSGGRKEVSSKNIKNKISSNNTKNRISSKSISNKQIETNLQSKLWSSSFLKASTGEMSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 257, "header": "tr|A0AAA9TUM3-1|ERIC2_BOVIN Computationally mapped isoform of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=1 CANONICAL=A6QQ66-1" }, "locus": { "chromosome": "2", "start_pos": 25684895, "end_pos": 25661993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088916.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088916.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100274.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100274.1" } ] } }, { "isoform_ac": "A0AAF6ZGB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGB2/entry", "sequence": { "sequence": "MIEPNEGMSEKEVSSKNIKNKISSNNTKNRISSKSISNKQIETNLQSKLWSSSFLKASTGEMSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 203, "header": "tr|A0AAF6ZGB2-1|ERIC2_BOVIN Computationally mapped isoform of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=1 CANONICAL=A6QQ66-1" }, "locus": { "chromosome": "2", "start_pos": 25684895, "end_pos": 25661993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046636.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046636.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043915.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043915.4" } ] } }, { "isoform_ac": "A0AAF7A5X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5X1/entry", "sequence": { "sequence": "MSTLPMLRVRGPQAGKRRRTERGRRLPISASNLTQFLPRTPSGPALEPANFSDRSRFGLWRPTTAQAAHEKESSRQDICCKGEMSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 225, "header": "tr|A0AAF7A5X1-1|ERIC2_BOVIN Computationally mapped isoform of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=1 CANONICAL=A6QQ66-1" }, "locus": { "chromosome": "2", "start_pos": 25694077, "end_pos": 25661993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086313.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086313.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063244.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063244.2" } ] } }, { "isoform_ac": "A6QQ66-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ66/entry#A6QQ66-1", "sequence": { "sequence": "MSKNVVIAEQEKNNEHCPEDINDKLSESTDDDGEDTSDEDKEEDSNPNKDTHAPLELMTEFLRAEMGHDYHLAKKLCQMILIYEPENPEAKEFFSLIEEMLLMEKAQNLEEDDDESEEDNSESEGESTEDPSEESSDECEDG", "length": 142, "header": "sp|A6QQ66-1|ERIC2_BOVIN Isoform 1 of Glutamate-rich protein 2 OS=Bos taurus OX=9913 GN=ERICH2 PE=2 SV=1 CANONICAL=A6QQ66-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615113", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615113", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L162-1", "protein_name": "Glutamate-rich protein 2", "gene_name": "ERICH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METVNEPETGEVSKDAVIVKQEKNNEYCLQDIDDKLSESAEDDGEDDTNDEDDDEDSNPKKNTQAPLELMAEFLRAEMAREYQLAKKLCQMILIYEPENPEAKEFFTLIEEMLLMEKTQNHEQDGENSDEDSSGESKGESDEELSDESSDEGEDGS", "length": 156 }, "evidence": [ { "id": "A6QQ66", "url": "https://omabrowser.org/oma/group/A6QQ66/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQ66-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQ66-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQ66" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7E2-1", "uniprot_ac": "E1B7E2", "uniprot_id": "E1B7E2_BOVIN", "mass": { "chemical_mass": 247359.0, "monoisotopic_mass": 247359.0 }, "refseq": {}, "gene_names": [ { "name": "DOCK3", "type": "recommended", "evidence": [ { "id": "E1B7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ] } ], "protein_names": [ { "name": "Dedicator of cytokinesis 3", "type": "synonym", "evidence": [ { "id": "E1B7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7E2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DOCK3", "url": "https://www.uniprot.org/uniprotkb/E1B7E2", "locus": { "chromosome": "22", "start_pos": 49386097, "end_pos": 49710099, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001874", "url": "https://www.ensembl.org/id/ENSBTAG00000001874" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001874", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001874", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08695", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08695", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11704", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11704", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12048", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12048", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45653", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45653", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45653:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45653:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14429", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14429", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16172", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16172", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20422", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23554", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23554", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M4Z4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN16", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN16-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MT94", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MT94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MT94-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MT94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0U1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0U1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0U1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7E2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7E2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGHPASPLRRAEPRRRREPSSEAVRDEAAAREQRGRTGGEPSPASTRTAGPPAEPHGPDVAAAASRTACEGCAAHCPAPPDLPRLGSRCATAGPAAVLAALSPGRRARGAAPGPAMWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2173, "header": "tr|E1B7E2-1|E1B7E2_BOVIN Isoform 1 of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=4 CANONICAL=E1B7E2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Z4/entry", "sequence": { "sequence": "MYLTDKEKNRVKPSIITVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2031, "header": "tr|A0A3Q1M4Z4-1|E1B7E2_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=2 CANONICAL=E1B7E2-1" }, "locus": { "chromosome": "22", "start_pos": 49665433, "end_pos": 49387101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087176.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087176.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064911.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064911.2" } ] } }, { "isoform_ac": "A0A3Q1ML51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML51/entry", "sequence": { "sequence": "MRGHPASPLRRAEPRRRREPSSEAVRDEAAAREQRGRTGGEPSPASTRTAGPPAEPHGPDVAAAASRTACEGCAAHCPAPPDLPRLGSRCATAGPAAVLAALSPGRRARGAAPGPAMWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2132, "header": "tr|A0A3Q1ML51-1|E1B7E2_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=2 CANONICAL=E1B7E2-1" }, "locus": { "chromosome": "22", "start_pos": 49688433, "end_pos": 49387101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079970.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079970.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071681.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071681.2" } ] } }, { "isoform_ac": "A0A3Q1MN16-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN16/entry", "sequence": { "sequence": "MYLTDKEKNRVKPSIITVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2018, "header": "tr|A0A3Q1MN16-1|E1B7E2_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=2 CANONICAL=E1B7E2-1" }, "locus": { "chromosome": "22", "start_pos": 49665433, "end_pos": 49387101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078542.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078542.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072604.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072604.2" } ] } }, { "isoform_ac": "A0A3Q1MT94-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MT94/entry", "sequence": { "sequence": "MYLTDKEKNRVKPSIITVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2053, "header": "tr|A0A3Q1MT94-1|E1B7E2_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=2 CANONICAL=E1B7E2-1" }, "locus": { "chromosome": "22", "start_pos": 49665433, "end_pos": 49387101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085032.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085032.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073482.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073482.2" } ] } }, { "isoform_ac": "A0A3Q1N0U1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0U1/entry", "sequence": { "sequence": "MRGHPASPLRRAEPRRRREPSSEAVRDEAAAREQRGRTGGEPSPASTRTAGPPAEPHGPDVAAAASRTACEGCAAHCPAPPDLPRLGSRCATAGPAAVLAALSPGRRARGAAPGPAMWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2164, "header": "tr|A0A3Q1N0U1-1|E1B7E2_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=2 CANONICAL=E1B7E2-1" }, "locus": { "chromosome": "22", "start_pos": 49688433, "end_pos": 49387101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085534.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085534.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062397.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062397.2" } ] } }, { "isoform_ac": "E1B7E2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7E2/entry", "sequence": { "sequence": "MRGHPASPLRRAEPRRRREPSSEAVRDEAAAREQRGRTGGEPSPASTRTAGPPAEPHGPDVAAAASRTACEGCAAHCPAPPDLPRLGSRCATAGPAAVLAALSPGRRARGAAPGPAMWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTARPRHGESCRIPVPHHFFLSLKSLTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSVLDVLQSLTELKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAGEYVSCLLSLLRQMCDTHYQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSTKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEERPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPEYVDVLQMDRVPDRVKSFYRVNNVRRFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHPGDAEKIAQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNVVMLGDSSMGEAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTHRDRPSSAMYPAAILENGQLPNFQRALFQQVVGACKPCSDPNLSVAEKAVPAAPSSWSLDSGAREAQPFLSAHTGCILAPPVPPRSLLHGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEVPARTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREEAERPRGLHRKASLPPGSTKEEQARMAWEHSRGEQ", "length": 2173, "header": "tr|E1B7E2-1|E1B7E2_BOVIN Isoform 1 of Dedicator of cytokinesis 3 OS=Bos taurus OX=9913 GN=DOCK3 PE=3 SV=4 CANONICAL=E1B7E2-1" }, "locus": { "chromosome": "22", "start_pos": 49688433, "end_pos": 49387101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002440.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002440.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002440.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002440.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "E1B7E2", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1124, "end_pos": 1126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1355, "end_pos": 1357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1831, "end_pos": 1833, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1929, "end_pos": 1931, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2025, "end_pos": 2027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" }, { "start_pos": 669, "end_pos": 671, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" }, { "id": "PS51650", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51650" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2 DOCK-type", "eco_id": "ECO_0000259", "start_pos": 537, "end_pos": 715, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" }, { "id": "PS51651", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51651" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DOCKER", "eco_id": "ECO_0000259", "start_pos": 1330, "end_pos": 1737, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7E2" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 183, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1124, "end_pos": 1126 }, { "start_pos": 1355, "end_pos": 1357 }, { "start_pos": 1831, "end_pos": 1833 }, { "start_pos": 1929, "end_pos": 1931 }, { "start_pos": 2025, "end_pos": 2027 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 586, "end_pos": 588 }, { "start_pos": 669, "end_pos": 671 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B703-1", "uniprot_ac": "E1B703", "uniprot_id": "E1B703_BOVIN", "mass": { "chemical_mass": 107946.0, "monoisotopic_mass": 107946.0 }, "refseq": {}, "gene_names": [ { "name": "PRPF40B", "type": "recommended", "evidence": [ { "id": "E1B703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B703" } ] } ], "protein_names": [ { "name": "Pre-mRNA-processing factor 40 homolog B", "type": "recommended", "evidence": [ { "id": "E1B703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B703/entry#names_and_taxonomy" } ] }, { "name": "Huntingtin yeast partner C", "type": "synonym", "evidence": [ { "id": "E1B703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B703/entry#names_and_taxonomy" } ] }, { "name": "Huntingtin-interacting protein C", "type": "synonym", "evidence": [ { "id": "E1B703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B703/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in pre-mRNA splicing.", "evidence": [ { "database": "UniProtKB", "id": "E1B703", "url": "https://www.uniprot.org/uniprotkb/E1B703#function" }, { "database": "UniProtKB", "id": "ARBA00058987", "url": "https://www.uniprot.org/uniprotkb/ARBA00058987#function" }, { "database": "UniProtKB", "id": "A0A3Q1M587", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M587#function" }, { "database": "UniProtKB", "id": "A0A3Q1NKH6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B703", "url": "https://www.uniprot.org/uniprotkb/E1B703" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRPF40B", "url": "https://www.uniprot.org/uniprotkb/E1B703", "locus": { "chromosome": "5", "start_pos": 30202308, "end_pos": 30240842, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016589", "url": "https://www.ensembl.org/id/ENSBTAG00000016589" } ] } } ], "crossref": [ { "id": "E1B703", "url": "https://alphafold.ebi.ac.uk/entry/E1B703", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016589", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016589", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513782", "url": "https://www.ncbi.nlm.nih.gov/gene/513782", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M587", "url": "https://www.orthodb.org/?gene=A0A3Q1M587", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKH6", "url": "https://www.orthodb.org/?gene=A0A3Q1NKH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B703", "url": "https://www.orthodb.org/?gene=E1B703", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11864", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11864", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11864:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11864:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01846", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01846", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M587", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M587", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M587-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M587-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKH6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKH6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B703", "url": "https://www.uniprot.org/uniprotkb/E1B703", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B703-1", "url": "https://www.uniprot.org/uniprotkb/E1B703-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYLMALTSPWLNMVESRSSCNMDFTSETFTQSVPDSGPRPPAAPAPFPPGPPMMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGIMPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQTLVKQEAAGKQQQPQALQPQPPQPQPDPPPVPPGPTLLPTGLLEPEPGGSEDCAVSEAAQPLEQGFLQQPEEGPSSSAGQHQPPQQEEEESKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQNMDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYPAVSTDIRFANMLGQPGKAAGLSLLWPGFLPCQSLCTPTPWSCPQPYPQALGSCRRQAPLPPSPTGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRLRRREAAFRSMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLETECQHLHSKGRKHGRKGKKHHRKRSHSPSGSESGDEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGSPSSRLLLGSDHGLRKAKKPKKKTKKRRHKSNSPESETDPEEKAAKESDEKEPEQDKDRDLRRAELPNRSPAFGVKKEKTGWDTSESELSEGELERRRRTLLQQLDDHQ", "length": 956, "header": "tr|E1B703-1|E1B703_BOVIN Isoform 1 of Pre-mRNA-processing factor 40 homolog B OS=Bos taurus OX=9913 GN=PRPF40B PE=3 SV=4 CANONICAL=E1B703-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M587-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M587/entry", "sequence": { "sequence": "MSVPDSGPRPPAAPAPFPPGPPMMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGIMPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQSKESRWTRPKDLDDLEALVKQEAAGKQQQPQALQPQPPQPQPDPPPVPPGPTLLPTGLLEPEPGGSEDCAVSEAAQPLEQGFLQQPEEGPSSSAGQHQPPQQEEEESKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQNMDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYPAVSTDIRFANMLGQPGKAAGLSLLWPGFLPCQSLCTPTPWSCPQPYPQALGSCRRQAPLPPSPTGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRLRRREAAFRSMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLETECQHLHSKGRKHGRKGKKHHRKRSHSPSGSESGDEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGSPSSRLLLGSDHGLRKAKKPKKKTKKRRHKSNSPESETDPEEKAAKESDEKEPEQDKDRDLRRAELPNRSPAFGVKKEKTGWDTSESELSEGELERRRRTLLQQLDDHQ", "length": 942, "header": "tr|A0A3Q1M587-1|E1B703_BOVIN Computationally mapped isoform of Pre-mRNA-processing factor 40 homolog B OS=Bos taurus OX=9913 GN=PRPF40B PE=3 SV=2 CANONICAL=E1B703-1" }, "locus": { "chromosome": "5", "start_pos": 30223068, "end_pos": 30203312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077702.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077702.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068795.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068795.2" } ] } }, { "isoform_ac": "A0A3Q1NKH6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH6/entry", "sequence": { "sequence": "MMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGIMPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQTLVKQEAAGKQQQPQALQPQPPQPQPDPPPVPPGPTLLPTGLLEPEPGGSEDCAVSEAAQPLEQGFLQQPEEGPSSSAGQHQPPQQEEEESKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQNMDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYPAVSTDIRFANMLGQPGKAAGLSLLWPGFLPCQSLCTPTPWSCPQPYPQALGSCRRQAPLPPSPTGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRLRRREAAFRSMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLETECQHLHSKGRKHGRKGKKHHRKRSHSPSGSESGDEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGSPSSRLLLGSDHGLRKAKKPKKKTKKRRHKSNSPESETDPEEKAAKESDEKEPEQDKDRDLRRAELPNRSPAFGVKKEKTGWDTSESELSEGELERRRRTLLQQLDDHQ", "length": 899, "header": "tr|A0A3Q1NKH6-1|E1B703_BOVIN Computationally mapped isoform of Pre-mRNA-processing factor 40 homolog B OS=Bos taurus OX=9913 GN=PRPF40B PE=3 SV=2 CANONICAL=E1B703-1" }, "locus": { "chromosome": "5", "start_pos": 30223068, "end_pos": 30203312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074031.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074031.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072844.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072844.2" } ] } }, { "isoform_ac": "E1B703-1", "url": "https://www.uniprot.org/uniprotkb/E1B703/entry", "sequence": { "sequence": "MYLMALTSPWLNMVESRSSCNMDFTSETFTQSVPDSGPRPPAAPAPFPPGPPMMPPPFMPPPGIPPPFPPMGLPPMSQRPPAIPPMPPGIMPPMLPPMGAPPPLTQIPGMVPPMMPGMLMPAVPVTAATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPWKEYKSDTGKPYYYNNQTLVKQEAAGKQQQPQALQPQPPQPQPDPPPVPPGPTLLPTGLLEPEPGGSEDCAVSEAAQPLEQGFLQQPEEGPSSSAGQHQPPQQEEEESKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNAYKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGELEVWAVVPERDRKEVYDDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDHQLQNMDKEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQTFLDELHETGQLHSMSTWMELYPAVSTDIRFANMLGQPGKAAGLSLLWPGFLPCQSLCTPTPWSCPQPYPQALGSCRRQAPLPPSPTGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVISFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRLRRREAAFRSMLRQAVPALELGTAWEEVRERFVCDSAFEQITLESERIRLFREFLQVLETECQHLHSKGRKHGRKGKKHHRKRSHSPSGSESGDEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVESGGAALGGRGSPSSRLLLGSDHGLRKAKKPKKKTKKRRHKSNSPESETDPEEKAAKESDEKEPEQDKDRDLRRAELPNRSPAFGVKKEKTGWDTSESELSEGELERRRRTLLQQLDDHQ", "length": 956, "header": "tr|E1B703-1|E1B703_BOVIN Isoform 1 of Pre-mRNA-processing factor 40 homolog B OS=Bos taurus OX=9913 GN=PRPF40B PE=3 SV=4 CANONICAL=E1B703-1" }, "locus": { "chromosome": "5", "start_pos": 30240801, "end_pos": 30203312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022067.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022067.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022067.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022067.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1B703", "url": "https://www.uniprot.org/uniprotkb/E1B703" } ], "pmid": "" }, { "name": "nuclear matrix", "id": "GO:0016363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "database": "UniProtKB", "id": "E1B703", "url": "https://www.uniprot.org/uniprotkb/E1B703" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA cis splicing, via spliceosome", "id": "GO:0045292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045292", "evidence": [ { "database": "UniProtKB", "id": "E1B703", "url": "https://www.uniprot.org/uniprotkb/E1B703" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 915, "end_pos": 917, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B703-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 956, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B703-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B703" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B703" }, { "id": "PS51676", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51676" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FF", "eco_id": "ECO_0000259", "start_pos": 312, "end_pos": 366, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B703" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 144, "end_pos": 177, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 915, "end_pos": 917 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAG3-1", "uniprot_ac": "E1BAG3", "uniprot_id": "E1BAG3_BOVIN", "mass": { "chemical_mass": 91711.0, "monoisotopic_mass": 91711.0 }, "refseq": {}, "gene_names": [ { "name": "TXNDC16", "type": "recommended", "evidence": [ { "id": "E1BAG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" } ] } ], "protein_names": [ { "name": "Thioredoxin domain containing 16", "type": "synonym", "evidence": [ { "id": "E1BAG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAG3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAG3", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TXNDC16", "url": "https://www.uniprot.org/uniprotkb/E1BAG3", "locus": { "chromosome": "10", "start_pos": 11709091, "end_pos": 11623049, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010399", "url": "https://www.ensembl.org/id/ENSBTAG00000010399" } ] } } ], "crossref": [ { "id": "E1BAG3", "url": "https://alphafold.ebi.ac.uk/entry/E1BAG3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010399", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010399", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02961", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02961", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536075", "url": "https://www.ncbi.nlm.nih.gov/gene/536075", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536075", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536075", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRRTLMG", "url": "https://omabrowser.org/oma/group/CRRTLMG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M6P4", "url": "https://www.orthodb.org/?gene=A0A3Q1M6P4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAG3", "url": "https://www.orthodb.org/?gene=E1BAG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22699", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22699", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22699:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22699:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13848", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13848", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24508", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24508", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24509", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24509", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24510", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24510", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M6P4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6P4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZF6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAG3", "url": "https://www.uniprot.org/uniprotkb/E1BAG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAG3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMPSSFSVFRAGISFVMMCIFYTSAVDSPELSPQTFFSTLQPGKATLVYFCQAESPRTSMFLEELNEAAKPLQDYGISVAKVNCVTEETSRYCGSEKDLIKAYLFRGNIPLREFPTDTLFDVDAILAHVLFALLFNEVKYITTLGDLQNIENALKGKRNIAFSYVRAIGTPEHRAVMEAAFVYGTTYQFVLTTEIAVLESIGPEDIEYPHLYFFYCKQVLDLTQPCRRILMKQSLTTLNIHRFIKTMEAPLLTEVAGDPTQVSTVHLQLGLPLVFIVGQQATYEADRTTAEWVAWRLLGKAGVLLLLRDSLEVDIPHDTNVIIRRAEEDTQVEFLALSHIDLIVFHLESTMNVEEMVKYEDMAELNIEIQDDEVEETVYRDRKRQLPLELTLELTEETFHATVTASDSIVLFYAGWQAVSMAFLQSYIDVAIKLKGTSTMLLARVNCADWSHVCTEQNVTEFPVVKMYKEGQNPVSYTGMLGTEDLLKFIQLNRISCPVNITSVQEAEEYLNGELYKDLISYSSMSVLGLFSPTMTRAKEEFTEAGSYLKGYVTTGIYSEEDVLRLSSKYTVTLPALLLARHKEGKIESIPLVNVHVHDIVQIITNASLETFPEITVENLPTYLRLQKPLLILFSDGGIDLQHEKTILRLAKKKYLDSVTPCWLNLKKTPVGRGVLQAYFGTLPPLPLLVVVNLHSGGHVFAFPSDQAVTKQNLLLWLKKLEAGLESPIKVLPAQEWKPPLPAYDFLSMMDAAASEHLARKVPECIKETDMHESDKEQPDDKSAITEESIGTSKMKHSSRSSWLEEIKKPLSSP", "length": 814, "header": "tr|E1BAG3-1|E1BAG3_BOVIN Isoform 1 of Thioredoxin domain containing 16 OS=Bos taurus OX=9913 GN=TXNDC16 PE=4 SV=3 CANONICAL=E1BAG3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6P4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6P4/entry", "sequence": { "sequence": "MMPSSFSVFRAGISFVMMCIFYTSAVDSPELSPQTFFSTLQPGKATLVYFCQAESPRTSMFLEELNEAAKPLQDYGISVAKVNCVTEETSRYCGSEKDLIKAYLFSPFGASVYAVRKGGRRKPCWDSCFFPVFLPTTELFKVSLSIRGNIPLREFPTDTLFDVDAILAHVLFALLFNEVKYITTLGDLQNIENALKGKRNIAFSYVRAIGTPEHRAVMEAAFVYGTTYQFVLTTEIAVLESIGPEDIEYPHLYFFYCKQVLDLTQPCRRILMKQSLTTLNIHRFIKTMEAPLLTEVAGDPTQVSTVHLQLGLPLVFIVGQQATYEADRTTAEWVAWRLLGKAGVLLLLRDSLEVDIPHDTNVIIRRAEEDTQVEFLALSHIDLIVFHLESTMNVEEMVKYEDMAELNIEIQDDEVEETVYRDRKRQLPLELTLELTEETFHATVTASDSIVLFYAGWQAVSMAFLQSYIDVAIKLKGTSTMLLARVNCADWSHVCTEQNVTEFPVVKMYKEGQNPVSYTGMLGTEDLLKFIQLNRISCPVNITSVQEAEEYLNGELYKDLISYSSMSVLGLFSPTMTRAKEEFTEAGSYLKGYVTTGIYSEEDVLRLSSKYTVTLPALLLARHKEGKIESIPLVNVHVHDIVQIITNASLETFPEITVENLPTYLRLQKPLLILFSDGGIDLQHEKTILRLAKKKYLDSVTPCWLNLKKTPVGRGVLQAYFGTLPPLPLLVVVNLHSGGHVFAFPSDQAVTKQNLLLWLKKLEAGLESPIKVLPAQEWKPPLPAYDFLSMMDAAASEHLARKVPECIKETDMHESDKEQPDDKSAITEESIGTSKMKHSSRSSWLEEIKKPLRHDNQEL", "length": 859, "header": "tr|A0A3Q1M6P4-1|E1BAG3_BOVIN Computationally mapped isoform of Thioredoxin domain containing 16 OS=Bos taurus OX=9913 GN=TXNDC16 PE=4 SV=2 CANONICAL=E1BAG3-1" }, "locus": { "chromosome": "10", "start_pos": 11707571, "end_pos": 11624344, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069909.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069909.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069424.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069424.2" } ] } }, { "isoform_ac": "A0A3Q1MZF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZF6/entry", "sequence": { "sequence": "MMPSSFSVFRAGISFVMMCIFYTSAVDSPELSPQTFFSTLQPGKATLVYFCQAESPRTSMFLEELNEAAKPLQDYGISVAKVNCVTEETSRYCGSEKDLIKAYLFRGNIPLREFPTDTLFDVDAILAHVLFALLFNEVKYITTLGDLQNIENALKGKRNIAFSYVRAIGTPEHRAVMEAAFVYGTTYQFVLTTEIAVLESIGPEDIEYPHLYFFYCKQVLDLTQPCRRILMKQSLTTLNIHRFIKTMEAPLLTEVAGDPTQVSTVHLQLGLPLVFIVGQQATYEADRTTAEWVAWRLLGKAGVLLLLRDSLEVDIPHDTNVIIRRAEEDTQVEFLALSHIDLIVFHLESTMNVEEMVKYEDMAELNIEIQDDEVEETVYRDRKRQLPLELTLELTEETFHATVTASDSIVLFYAGWQAVSMAFLQSYIDVAIKLKGTSTMLLARVNCADWSHVCTEQNVTEFPVVKMYKEGQNPVSYTGMLGTEDLLKFIQLNRISCPVNITSVQEAEEYLNGELYKDLISYSSMSVLGLFSPTMTRAKEEFTEAGSYLKGYVTTGIYSEEDVLRLSSKYTVTLPALLLARHKEGKIESIPLVNVHVHDIVQIITNASLETFPEITVENLPTYLRLQKPLLILFSDGGIDLQHEKTILRLAKKKYLDSVTPCWLNLKKTPVGRGVLQAYFGTLPPLPLLVVVNLHSGGHVFAFPSDQAVTKQNLLLWLKKLEAGLESPIKVLPAQEWKPPLPAYDFLSMMDAAASEHLARKVPECIKETDMHESDKEQPDDKSAITEESIGTSKMKHSSRSSWLEEIKKPLRHDNQEL", "length": 818, "header": "tr|A0A3Q1MZF6-1|E1BAG3_BOVIN Computationally mapped isoform of Thioredoxin domain containing 16 OS=Bos taurus OX=9913 GN=TXNDC16 PE=4 SV=1 CANONICAL=E1BAG3-1" }, "locus": { "chromosome": "10", "start_pos": 11707571, "end_pos": 11624344, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084670.1", "url": "https://www.ensembl.org/id/ENSBTAT00000084670.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061603.1" } ] } }, { "isoform_ac": "E1BAG3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAG3/entry", "sequence": { "sequence": "MMPSSFSVFRAGISFVMMCIFYTSAVDSPELSPQTFFSTLQPGKATLVYFCQAESPRTSMFLEELNEAAKPLQDYGISVAKVNCVTEETSRYCGSEKDLIKAYLFRGNIPLREFPTDTLFDVDAILAHVLFALLFNEVKYITTLGDLQNIENALKGKRNIAFSYVRAIGTPEHRAVMEAAFVYGTTYQFVLTTEIAVLESIGPEDIEYPHLYFFYCKQVLDLTQPCRRILMKQSLTTLNIHRFIKTMEAPLLTEVAGDPTQVSTVHLQLGLPLVFIVGQQATYEADRTTAEWVAWRLLGKAGVLLLLRDSLEVDIPHDTNVIIRRAEEDTQVEFLALSHIDLIVFHLESTMNVEEMVKYEDMAELNIEIQDDEVEETVYRDRKRQLPLELTLELTEETFHATVTASDSIVLFYAGWQAVSMAFLQSYIDVAIKLKGTSTMLLARVNCADWSHVCTEQNVTEFPVVKMYKEGQNPVSYTGMLGTEDLLKFIQLNRISCPVNITSVQEAEEYLNGELYKDLISYSSMSVLGLFSPTMTRAKEEFTEAGSYLKGYVTTGIYSEEDVLRLSSKYTVTLPALLLARHKEGKIESIPLVNVHVHDIVQIITNASLETFPEITVENLPTYLRLQKPLLILFSDGGIDLQHEKTILRLAKKKYLDSVTPCWLNLKKTPVGRGVLQAYFGTLPPLPLLVVVNLHSGGHVFAFPSDQAVTKQNLLLWLKKLEAGLESPIKVLPAQEWKPPLPAYDFLSMMDAAASEHLARKVPECIKETDMHESDKEQPDDKSAITEESIGTSKMKHSSRSSWLEEIKKPLSSP", "length": 814, "header": "tr|E1BAG3-1|E1BAG3_BOVIN Isoform 1 of Thioredoxin domain containing 16 OS=Bos taurus OX=9913 GN=TXNDC16 PE=4 SV=3 CANONICAL=E1BAG3-1" }, "locus": { "chromosome": "10", "start_pos": 11708590, "end_pos": 11624344, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013728.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013728.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013728.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013728.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536075", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536075", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQK4-1", "protein_name": "Thioredoxin domain containing 16", "gene_name": "Txndc16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNQSTSGSSITSGVRTQQVKKTDKSPGTRIQPQLTMSSGLRVFRAGVALVLMCNFYTSTEDSLPELSPQQYFSSLQPGKASLAYFCQDGSLSNSLFLEELKEAIRPLQDYGISVAKVTCVKEEASRYCGEEESLMKAYLFRGSILLREFPTDILFDVNAIIAHVLFALLFNEVKYITTLEDLHSIENSLKGKSNMIFSYVEAIGTPEHRAVMEAAFVYGTSYQFALTTEIALLEDVGSENIEHAHLYFFHCKVVSDVTEHCRRTLMGPPLAAVEVHKFVKTMEAPLLTEVAEDPQLVSTIHLQLGLPLVFIISQRATHEADRRTAEWVAWQLLGKAGVLLLMRDSADVNIPQHANVAFRRAEKDAPVEFQVLNDVELIISHVKNNLYFEEIQEDEGEDMEGPDLAVEDDEVAGTVYRDRKRPLPLGLLVELTEETFNTTVMASDTLVLFYATWHAVSMAFLQSYTDVAVKLKGRSTILLTRINCADWSDVCTKQNVTAFPMVKLYKEGESPVSYAGMLGSKDLLTFIQLNKISSPVNIASIQEAEKYLRGELYKDLFSFSSVSVLGLFTPAMTSAKECFQKAGKQLRGSVLTGVYSEDDAWILSNKYATTLPALLLARPKEGRIESVPLDTTPVQDMVQILANAPLEAFPEITVENLPTYLRFQRPLLILFSDGSINPQYRNIVLALVRQKQLDLFTPCWLNLKNTPVGRGVLKAYFGRLPTLPQLLLVNLHSGGQVYAFPSSQPLTEQSLVLWLKNSQAGLENPIILSAQEWSPPLPAFDFLSMMDVPTSRAPTKKVLECQKEAEVQERAGQQPGDKSTTRREPVEVLRIKHWNRSNRPKESREPFHHDKEL", "length": 853 }, "evidence": [ { "id": "E1BAG3", "url": "https://omabrowser.org/oma/group/E1BAG3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FC06-1", "protein_name": "Thioredoxin domain-containing protein 16", "gene_name": "txndc16", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MCTVYLVTFVFILTAEQCFSKLMEDSGQNLMERMQTGKTSFIYFGNHVNPTIELFIEQLQMSADALEDYGIAVVMVNCSKDDIAKYCTGEKLLTKAYLFRGSEVLRSFDIDTVFDVNAIVSHVLFSVLFNEVLYVHTPAELLGVESAAKQNSDIVVGHIPVLGLPEHRALMETAFVYGTKYQFVQTTGSLVLKRMGVVNPSSSQARLWFLHCKSVSLQSDPCPSTAMSKPINTINIHTFLQLMEAPLVTEAVTDPSEVDVVHIHLSVPVLYLFSQPQTQHLDRDTAQTVALQLRGEVGVVLIHRDNPKVKTPLKYNAAYRLPQEDVKYFTLSAPEEVVKLFKETLLQKDKTEDEEEDDEHWSDLDILDDEVSESVYRDRDLMLDLEPVTELTADTFQTAIKQNEITVVLFYFKWDAVCMAFIQSYVEVAEAVEDVNGVELAAVDCGEWTDICRDQNITSFPTVLIYCPKAAAAQPYRGMMGTKSLQRFILLSLVSTPVHLSSSAEVMSFLEGDLYRKYVYLTPVRVLGLFSSMQDMGVSSFEEAARLLRGETIIGLFAHKEAAKWVEGLSVNLPALLVSHGPALPHQVFSLPSSLATDHVKLIQRVELERFPELTVENLPWYLELEKPLLLLFIGKEESTESTRSLAEINQLLGSGQLDFFLPCWIHLGRTPVGRSILEKYLGFVPPLPSLVISQIKTGGEVFLFPSERPLKAENILRWIHDVEDRHEQPAGLIPDVKWGPPVPFFDFLAIMDQEAPTYAAQKAPKTKNGGRENHKEQNHVTPNQSQGPHPSANPQAPRRHSEL", "length": 804 }, "evidence": [ { "id": "E1BAG3", "url": "https://omabrowser.org/oma/group/E1BAG3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7TN22-1", "protein_name": "Thioredoxin domain-containing protein 16", "gene_name": "Txndc16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMSSGFSVFRAGVALVLMCSFYKSTEDSLPELTPQQYFSTLQPGKASLVYFCQVGSLSNSVFLEELKEAVKPLQDYGISVAKVTCVEEEASRYCGEEEGLMKAYLFRGNILLREFPTDILFDVNAIIAHVLFALLFNEVKYITTLEDLHSIENSLKGKSNMIFSYVEAIGTPEHRAVMEAAFVYGTSYQFALTTEIALLENIGSESIEHAHLYFFHCKLVLDLTEHCRRTLMEQPLTTLNIHVFVKTMNAPLLMEVAEDPQQVSTVHLQLGLPLVFIISQRATQEADRRTAEWVAWHLLGKAGVLLLLRDSMDVNIPQHANVAFRRAEKDVPVEFLVLNDVELIISHVKNNMHIEEIQEDEGEDMEGPDLAVEDDEVAGTVYRDRKKPLPLELSVELTEETFNTTVMTSDSIVLFYATWHAVSMAFLQSYIDVAIKLKGRSTILLTRINCADWSDICTKQNVTAFPVVKLYKEGESPVSYAGMLATKDLLKFIQLNKISCPVNIASIQEAEKYLRGELYKDLPSSASVSVLGLFSPAMASAKELFREAGKQLRGSVITGIYSEDDVWILSNKYATTLPALLLARPKEGRIESVPLDTTLVQDMAQILANALLEAFPEITVENLPTYLRFQRPLLLLFSGGSINPQYRNTILALVRQKQLDSFTPCWLNLKNTPVGRGILKAYFGRLPPLPQLLLVNLHSGGQVYAFPSSQSVTEQSLVLWLKHLQAGLENPITVLSAQEWKPPLPAFDFLNMMDAPTSQAPTKKVLECQKEAEVQESAELQPGDRSTARREPVEMLRIKRWNTANWPKDTQEPFHHDKEL", "length": 820 }, "evidence": [ { "id": "E1BAG3", "url": "https://omabrowser.org/oma/group/E1BAG3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2K2-1", "protein_name": "Thioredoxin domain-containing protein 16", "gene_name": "TXNDC16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSGFNVFRVGISFVIMCIFYMPTVNSLPELSPQKYFSTLQPGKASLAYFCQADSPRTSVFLEELNEAVRPLQDYGISVAKVNCVKEEISRYCGKEKDLMKAYLFKGNILLREFPTDTLFDVNAIVAHVLFALLFSEVKYITNLEDLQNIENALKGKANIIFSYVRAIGIPEHRAVMEAAFVYGTTYQFVLTTEIALLESIGSEDVEYAHLYFFHCKLVLDLTQQCRRTLMEQPLTTLNIHLFIKTMKAPLLTEVAEDPQQVSTVHLQLGLPLVFIVSQQATYEADRRTAEWVAWRLLGKAGVLLLLRDSLEVNIPQDANVVFKRAEEGVPVEFLVLHDVDLIISHVENNMHIEEIQEDEDNDMEGPDIDVQDDEVAETVFRDRKRKLPLELTVELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQEAEEYLSGELYKDLILYSSVSVLGLFSPTMKTAKEDFSEAGNYLKGYVITGIYSEEDVLLLSTKYAASLPALLLARHTEGKIESIPLASTHAQDIVQIITDALLEMFPEITVENLPSYFRLQKPLLILFSDGTVNPQYKKAILTLVKQKYLDSFTPCWLNLKNTPVGRGILRAYFDPLPPLPLLVLVNLHSGGQVFAFPSDQAIIEENLVLWLKKLEAGLENHITILPAQEWKPPLPAYDFLSMIDAATSQRGTRKVPKCMKETDVQENDKEQHEDKSAVRKEPIETLRIKHWNRSNWFKEAEKSFRRDKELGCSKVN", "length": 825 }, "evidence": [ { "id": "E1BAG3", "url": "https://omabrowser.org/oma/group/E1BAG3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "E1BAG3", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 606, "end_pos": 608, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAG3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 814, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAG3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAG3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" }, { "id": "PF24508", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24508" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TXNDC16 N-terminal", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 130, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BAG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" }, { "id": "PF24509", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24509" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TXNDC16 second thioredoxin-like", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 250, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BAG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" }, { "id": "PF24510", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24510" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TXNDC16 third thioredoxin-like", "eco_id": "ECO_0000259", "start_pos": 251, "end_pos": 341, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BAG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAG3" }, { "id": "PF00085", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin", "eco_id": "ECO_0000259", "start_pos": 392, "end_pos": 491, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 458, "end_pos": 460 }, { "start_pos": 500, "end_pos": 502 }, { "start_pos": 606, "end_pos": 608 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAL9-1", "uniprot_ac": "E1BAL9", "uniprot_id": "E1BAL9_BOVIN", "mass": { "chemical_mass": 38444.0, "monoisotopic_mass": 38444.0 }, "refseq": { "ac": "XP_024833567", "name": "aspartate beta-hydroxylase domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833567" }, "gene_names": [ { "name": "ASPHD2", "type": "recommended", "evidence": [ { "id": "E1BAL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL9" } ] }, { "name": "ASPHD2", "type": "synonym", "evidence": [ { "id": "XP_024833567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833567" } ] } ], "protein_names": [ { "name": "Aspartate beta-hydroxylase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "E1BAL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL9/entry#names_and_taxonomy" } ] }, { "name": "aspartate beta-hydroxylase domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_024833567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833567" } ] } ], "function": [ { "annotation": "May function as 2-oxoglutarate-dependent dioxygenase.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M733", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M733#function" }, { "database": "UniProtKB", "id": "ARBA00059268", "url": "https://www.uniprot.org/uniprotkb/ARBA00059268#function" }, { "database": "UniProtKB", "id": "A0AAA9TY06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY06#function" }, { "database": "UniProtKB", "id": "E1BAL9", "url": "https://www.uniprot.org/uniprotkb/E1BAL9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAL9", "url": "https://www.uniprot.org/uniprotkb/E1BAL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASPHD2", "url": "https://www.uniprot.org/uniprotkb/E1BAL9", "locus": { "chromosome": "17", "start_pos": 66118672, "end_pos": 66099076, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037832", "url": "https://www.ensembl.org/id/ENSBTAG00000037832" } ] } } ], "crossref": [ { "id": "E1BAL9", "url": "https://alphafold.ebi.ac.uk/entry/E1BAL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037832", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037832", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541223", "url": "https://www.ncbi.nlm.nih.gov/gene/541223", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007803", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007803", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541223", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541223", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HIPSKDC", "url": "https://omabrowser.org/oma/group/HIPSKDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M733", "url": "https://www.orthodb.org/?gene=A0A3Q1M733", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAL9", "url": "https://www.orthodb.org/?gene=E1BAL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46332", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46332", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46332:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46332:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833567", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M733", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M733", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M733-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M733-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL9", "url": "https://www.uniprot.org/uniprotkb/E1BAL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLEWLVAWGWSLDGLRDCIAAGIQSVRDCDTTAAVSVACLLALFVWYCYHVGREQPRAYASVNALMQGPDAAGLQNGFVYCQSAECVRCSHSEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSRPSIQKPEVFFLPDLPTAPYFSREAQKHDVELLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWVTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACLSVLSPGTVITEHYGPTNIRVRCHLGLKTPSGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGPAEDGPRAVFMVDLWHPHVAAAERQALDFIFAPGR", "length": 343, "header": "tr|E1BAL9-1|E1BAL9_BOVIN Isoform 1 of Aspartate beta-hydroxylase domain-containing protein 2 OS=Bos taurus OX=9913 GN=ASPHD2 PE=3 SV=3 CANONICAL=E1BAL9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M733-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M733/entry", "sequence": { "sequence": "MSLEWLVAWGWSLDGLRDCIAAGIQSVRDCDTTAAVSVACLLALFVWYCYHVGREQPRAYASVNALMQGPDAAGLQNGFVYCQSAECVRCSHSEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSRPSIQKPEVFFLPDLPTAPYFSREAQKHDVELLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWVTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACLSVLSPGTVITEHYGPTNIRVRCHLGLKTPSGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEEVQIHFVPDAPWPRIKVKFQEDSILVHTVVLTADHPLFPIMPIPATLDASAPRREAFS", "length": 365, "header": "tr|A0A3Q1M733-1|E1BAL9_BOVIN Computationally mapped isoform of Aspartate beta-hydroxylase domain-containing protein 2 OS=Bos taurus OX=9913 GN=ASPHD2 PE=3 SV=2 CANONICAL=E1BAL9-1" }, "locus": { "chromosome": "17", "start_pos": 66118147, "end_pos": 66099275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082662.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082662.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064204.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064204.2" } ] } }, { "isoform_ac": "A0AAA9TY06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY06/entry", "sequence": { "sequence": "MSLEWLVAWGWSLDGLRDCIAAGIQSVRDCDTTAAVSVACLLALFVWYCYHVGREQPRAYASVNALMQGPDAAGLQNGFVYCQSAECVRCSHSEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSRPSIQKPEVFFLPDLPTAPYFSREAQKHDVELLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWVTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACLSVLSPGTVITEHYGPTNIRVRCHLGLKTPSGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEEVQIHFVPDAPWPRIKVKFQEDSILVHTVVLTADHPLFPIMPIPATLDASP", "length": 358, "header": "tr|A0AAA9TY06-1|E1BAL9_BOVIN Computationally mapped isoform of Aspartate beta-hydroxylase domain-containing protein 2 OS=Bos taurus OX=9913 GN=ASPHD2 PE=3 SV=1 CANONICAL=E1BAL9-1" }, "locus": { "chromosome": "17", "start_pos": 66113264, "end_pos": 66099275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133639.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133639.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103539.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103539.1" } ] } }, { "isoform_ac": "E1BAL9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL9/entry", "sequence": { "sequence": "MSLEWLVAWGWSLDGLRDCIAAGIQSVRDCDTTAAVSVACLLALFVWYCYHVGREQPRAYASVNALMQGPDAAGLQNGFVYCQSAECVRCSHSEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSRPSIQKPEVFFLPDLPTAPYFSREAQKHDVELLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWVTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACLSVLSPGTVITEHYGPTNIRVRCHLGLKTPSGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGPAEDGPRAVFMVDLWHPHVAAAERQALDFIFAPGR", "length": 343, "header": "tr|E1BAL9-1|E1BAL9_BOVIN Isoform 1 of Aspartate beta-hydroxylase domain-containing protein 2 OS=Bos taurus OX=9913 GN=ASPHD2 PE=3 SV=3 CANONICAL=E1BAL9-1" }, "locus": { "chromosome": "17", "start_pos": 66106183, "end_pos": 66099275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055936.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055936.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052498.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052498.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541223", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541223", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BSD3-1", "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "ASPHD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPLVWLPDWSCSLDGLRDFIAAGIQSFRDCDGGALLAVGCLLLLFVWYCYHVGREQPRAYPAVNALMQGAEANGVQNGFVYCHAPECARCSPHDGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRPSIQKPEVFFLPDLPTAPYFSRDAQKHDVEVLERNFQTILCEFESLYKAFSNCSLPQGWKMNSTPSGEWFTFYLVNQGMCVPRNCRRCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVIAEHYGPTNIRIRCHLGLKTPSNCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGPPEEGPRVVFMVDLWHPNVAAAERQALDFIFAPGR", "length": 343 }, "evidence": [ { "id": "E1BAL9", "url": "https://omabrowser.org/oma/group/E1BAL9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RG81-1", "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "ASPHD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLEWLVAWGWSLDGLRDCIATGIQSVRDCDTTAVVTVACLLVLFVWYCYHVGREQPRPYVSVNALMQGPDANGLQNGFVYCQSPECVRCSHNGGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRPSIQKPEVFFLPDLPTTPYFSRDAQKHDVELLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWVTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPGGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR", "length": 343 }, "evidence": [ { "id": "E1BAL9", "url": "https://omabrowser.org/oma/group/E1BAL9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HTB6-1", "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "Asphd2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWLEWLVAWSWSLDGLRDCIATGIQSVRDCDSTAVVTVACLLVMFVWYCYHVGREQPRPHVSVNSLLQGVDASVLQNGSMYCQSPECVRCMHHDGLNQKLYHNLQEYAKRYSWSGMGRIHKAIREQGRYLSSQPSIQKPEVFFLPDLPTTPYFSRDAQKHDVELLERNFQAILCEFETLYKAFSNCSLPQGWKVNSTPSGEWFTFDFVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPSGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR", "length": 343 }, "evidence": [ { "id": "E1BAL9", "url": "https://omabrowser.org/oma/group/E1BAL9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5HZW3-1", "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "Asphd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLEWLVAWSWSLDGLRDCIATGIQSVRDCDGTAVITVACLLVLFVWYCYHVGREQPRPHVSVNSLLQGVDANGLQNGSMYCQSPECVRCTHHDGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSQPSIQKPEVFFLPDLPTTPYFPRDAQKHDVELLERNFQAILCEFEALYKAFSNCSLPQGWKVNSTPSGEWFTFDFVSQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHTSFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR", "length": 343 }, "evidence": [ { "id": "E1BAL9", "url": "https://omabrowser.org/oma/group/E1BAL9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ICH7-1", "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "ASPHD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVWAPLGPPRTDCLTLLHTPSKDSPKMSLEWLVAWSWSLDGLRDCIATGIQSVRDCDTTAVITVACLLVLFVWYCYHVGREQPRPYVSVNSLMQAADANGLQNGYVYCQSPECVRCTHNEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRPSIQKPEVFFLPDLPTTPYFSRDAQKHDVEVLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWFTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHAAFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR", "length": 369 }, "evidence": [ { "id": "E1BAL9", "url": "https://omabrowser.org/oma/group/E1BAL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80VP9-1", "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "Asphd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWLEWLVAWSWSLDGLRDCIATGIQSVRDCDGTAVITVACLLILFVWYCYHVGREQPRPHVSVNSLLQGVDANGLQNGSMYCQSPECARCTHHEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSQPSIQKPEVFFLPDLPTTPYFSRDAQKHDVELLERNFQAILCEFETLYKAFSNCSLPQGWKVNSTPSGEWFTFDFVSQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR", "length": 343 }, "evidence": [ { "id": "E1BAL9", "url": "https://omabrowser.org/oma/group/E1BAL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BAL9", "url": "https://www.uniprot.org/uniprotkb/E1BAL9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dioxygenase activity", "id": "GO:0051213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051213", "evidence": [ { "database": "UniProtKB", "id": "E1BAL9", "url": "https://www.uniprot.org/uniprotkb/E1BAL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL9" }, { "id": "PF05118", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aspartyl/asparaginy/proline hydroxylase", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 325, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 }, { "start_pos": 195, "end_pos": 197 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBF9-1", "uniprot_ac": "E1BBF9", "uniprot_id": "E1BBF9_BOVIN", "mass": { "chemical_mass": 25006.0, "monoisotopic_mass": 25006.0 }, "refseq": { "ac": "XP_005206975", "name": "FGFR1 oncogene partner 2 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206975" }, "gene_names": [ { "name": "FGFR1OP2", "type": "recommended", "evidence": [ { "id": "E1BBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF9" } ] }, { "name": "FGFR1OP2", "type": "synonym", "evidence": [ { "id": "XP_005206975", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206975" } ] } ], "protein_names": [ { "name": "FGFR1 onco partner 2", "type": "synonym", "evidence": [ { "id": "E1BBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF9/entry#names_and_taxonomy" } ] }, { "name": "FGFR1 oncogene partner 2 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005206975", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206975" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBF9", "url": "https://www.uniprot.org/uniprotkb/E1BBF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FGFR1OP2", "url": "https://www.uniprot.org/uniprotkb/E1BBF9", "locus": { "chromosome": "5", "start_pos": 82845014, "end_pos": 82857476, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004532", "url": "https://www.ensembl.org/id/ENSBTAG00000004532" } ] } } ], "crossref": [ { "id": "E1BBF9", "url": "https://alphafold.ebi.ac.uk/entry/E1BBF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004532", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004532", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532881", "url": "https://www.ncbi.nlm.nih.gov/gene/532881", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KYRQHTE", "url": "https://omabrowser.org/oma/group/KYRQHTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M7M7", "url": "https://www.orthodb.org/?gene=A0A3Q1M7M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBF9", "url": "https://www.orthodb.org/?gene=E1BBF9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12186", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12186", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12186:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12186:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05769", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05769", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005206975", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206975", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7M7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7M7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7M7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBF9", "url": "https://www.uniprot.org/uniprotkb/E1BBF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBF9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHTKELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKEDVSESTSLSALVTSSDLSLRKS", "length": 215, "header": "tr|E1BBF9-1|E1BBF9_BOVIN Isoform 1 of FGFR1 onco partner 2 OS=Bos taurus OX=9913 GN=FGFR1OP2 PE=3 SV=2 CANONICAL=E1BBF9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M7M7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7M7/entry", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHTKIDMVHRNSSEGFFLGASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKEDVSESTSLSALVTSSDLSLRKS", "length": 253, "header": "tr|A0A3Q1M7M7-1|E1BBF9_BOVIN Computationally mapped isoform of FGFR1 onco partner 2 OS=Bos taurus OX=9913 GN=FGFR1OP2 PE=3 SV=1 CANONICAL=E1BBF9-1" }, "locus": { "chromosome": "5", "start_pos": 82857474, "end_pos": 82846018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074676.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074676.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064387.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064387.1" } ] } }, { "isoform_ac": "E1BBF9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF9/entry", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHTKELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKEDVSESTSLSALVTSSDLSLRKS", "length": 215, "header": "tr|E1BBF9-1|E1BBF9_BOVIN Isoform 1 of FGFR1 onco partner 2 OS=Bos taurus OX=9913 GN=FGFR1OP2 PE=3 SV=2 CANONICAL=E1BBF9-1" }, "locus": { "chromosome": "5", "start_pos": 82857474, "end_pos": 82846018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005959.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005959.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005959.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005959.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VJ49-1", "protein_name": "FGFR1 onco partner 2", "gene_name": "FGFR1OP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALSKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERILQLEQENKGLREILQITRESFLNLRKDDVSESTSLSALVTNSDLSLRKS", "length": 215 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MD82-1", "protein_name": "FGFR1 oncogene partner 2 isoform X1", "gene_name": "Fgfr1op2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALSKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRSSREGVFLDASRRILEAPQHGLERRHLEANQNELQAHADQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLSALVTNSDLSLRKS", "length": 253 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ZKJ4-1", "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "FGFR1OP2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKMSCTIEKALADAKALVERLREHDNAAEALIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPSIIMKLKEQHSKELQVHVDQITEMAAVMRKAIEIDDKHGCKEQERIIQLEQENKGLREILQITRESFLNLKKEDASESTSLSGLVTSSDLSLRKS", "length": 217 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6TA25-1", "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "Fgfr1op2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALSKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNSCEGFFLDASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLSALVTNSDLSLRKS", "length": 253 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7T338-1", "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "fgfr1op2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTCTLEKVLADAKSLVERLRDHDSAAEILIEQTTLLNKRVEAMKQYQEEIEVLNQVARHRPRSTLVMGIQQENRQIRELQQENKELHTSLEEHQSALELIMSKYREQVFRLLMASKKEDPTIVTQLREQHTNEMQAHIEKINEMATVMRKAIEVDEGRLCEDEERIKRLELENSGLRELLGISREAFLLLKRDDTSDSTSLSPLLTSTDISLRKS", "length": 215 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CRA9-1", "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "Fgfr1op2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALSKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNSCEGFFLDASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLSALVTNSDLSLRKS", "length": 253 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVK5-1", "protein_name": "FGFR1 oncogene partner 2", "gene_name": "FGFR1OP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNKSEGFFLDASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLSALVTNSDLSLRKS", "length": 253 }, "evidence": [ { "id": "E1BBF9", "url": "https://omabrowser.org/oma/group/E1BBF9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBF9", "url": "https://www.uniprot.org/uniprotkb/E1BBF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BBF9", "url": "https://www.uniprot.org/uniprotkb/E1BBF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "E1BBF9", "url": "https://www.uniprot.org/uniprotkb/E1BBF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A5PKC7-1", "uniprot_ac": "A5PKC7", "uniprot_id": "CX049_BOVIN", "mass": { "chemical_mass": 56415.0, "monoisotopic_mass": 56415.0 }, "refseq": { "ac": "NP_001092664", "name": "uncharacterized protein CXorf49 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092664" }, "gene_names": [ { "name": "MGC152340", "type": "recommended", "evidence": [ { "id": "A5PKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKC7" } ] }, { "name": "MGC152340", "type": "synonym", "evidence": [ { "id": "NP_001092664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092664" } ] } ], "protein_names": [ { "name": "Uncharacterized protein CXorf49 homolog", "type": "recommended", "evidence": [ { "id": "A5PKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKC7/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein CXorf49 homolog", "type": "synonym", "evidence": [ { "id": "NP_001092664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092664" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A5PKC7", "url": "https://www.uniprot.org/uniprotkb/A5PKC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A5PKC7", "locus": {} } ], "crossref": [ { "id": "A5PKC7", "url": "https://alphafold.ebi.ac.uk/entry/A5PKC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048569", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048569", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785476", "url": "https://www.ncbi.nlm.nih.gov/gene/785476", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785476", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785476", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ALNPCPG", "url": "https://omabrowser.org/oma/group/ALNPCPG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8K9", "url": "https://www.orthodb.org/?gene=A0A3Q1M8K9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A5PKC7", "url": "https://www.orthodb.org/?gene=A5PKC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31866", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31866", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31866:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31866:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092664", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8K9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8K9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8K9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8K9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A5PKC7", "url": "https://www.uniprot.org/uniprotkb/A5PKC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A5PKC7-1", "url": "https://www.uniprot.org/uniprotkb/A5PKC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSDDEVLVWGPGFGSECGEQTSGLEAGSTAPRGPGPDPGPEPGAPQSGEGEGGDGFPDPEGFESEREVLEAGGPVLLGCEGRPGSPADDTGYVVQLSDESVAAILRQLADLDLLGIRRHMSPESHGVGDVSPLRDVEARPGSRGAAAQRCGEAARAEAGPRWVGRPRAGRAWGNPKRSTNVAVDRQWPPSVSPARLFSDSESSDECSEIQPMRVSIYPKDGGQAKLNSPKDPRDTPRHSNVQGRETLPNVPGTCLSSAPRGLISVVERQGKQGDAEQETISPPKKIQSVLWGKGGSLPSFPGVAAAAATAAAATGRLPRPSPRRKRVQEKKSLGGVSKPALGRTFPSWGRGISATPLDPATFPPISGIPLLGRSQKYASVPWGAKESKHTGAGKKSVARRARELVAATAVSGEDNDPNRDPVPKGQLATDRPWPSCPRVHHGEPSTANLSIRGGQDSGNSKPVAMNKGEVMPRGPGPSGDQKPADHHPRLKRRQQPPRRQGCPRCLVLQKEIDDLKEQLASMQYLAEKFRIL", "length": 534, "header": "sp|A5PKC7-1|CX049_BOVIN Isoform 1 of Uncharacterized protein CXorf49 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A5PKC7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8K9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8K9/entry", "sequence": { "sequence": "MSSSDDEVLVWGPGFGSECGEQTSGLEAGSTAPRGPGPDPGPEPGAPQSGEGEGGDGFPDPEGFESEREVLEAGGPVLLGCEGRPGSPADDTGYVVQLSDESVAAILRQLADLDLLGIRRHMSPESHGVGDVSPLRDVEARPGSRGAAAQRCGEAARAEAGPRWVGRPRAGRAWGNPKRSTNVAVDRQWPPSVSPARLFSDSESSDECSEIQPMRVSIYPKDGGQAKLNSPKDPRDTPRHSNVQGRETLPNVPGTCLSSAPRGLISVVERQGKQGDAEQETISPPKKIQSVLWGKGGSLPSFPGVAAAAATAAAATGRLPRPSPRRKRVQEKKSLGGVSKPALGRTFPSWGRGISATPLDPATFPPISGIPLLGRSQKYASVPWGAKESKHTGAGKKSVARRARELVAATAVSGEDNDPNRDPVPKGQLATDRPWPSCPRVHHGEPSTANLSIRGGQDSGNSKPVAMNKGEVMPRGPGPSGDQKPADHHPRLKRRQQPPRRQGCPRHLFMPLPVAASMQYLAEKFRIL", "length": 528, "header": "tr|A0A3Q1M8K9-1|CX049_BOVIN Computationally mapped isoform of Uncharacterized protein CXorf49 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A5PKC7-1" }, "locus": { "chromosome": "NKLS02000966.1", "start_pos": 91808, "end_pos": 88207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070591.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070591.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070253.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070253.1" } ] } }, { "isoform_ac": "A5PKC7-1", "url": "https://www.uniprot.org/uniprotkb/A5PKC7/entry#A5PKC7-1", "sequence": { "sequence": "MSSSDDEVLVWGPGFGSECGEQTSGLEAGSTAPRGPGPDPGPEPGAPQSGEGEGGDGFPDPEGFESEREVLEAGGPVLLGCEGRPGSPADDTGYVVQLSDESVAAILRQLADLDLLGIRRHMSPESHGVGDVSPLRDVEARPGSRGAAAQRCGEAARAEAGPRWVGRPRAGRAWGNPKRSTNVAVDRQWPPSVSPARLFSDSESSDECSEIQPMRVSIYPKDGGQAKLNSPKDPRDTPRHSNVQGRETLPNVPGTCLSSAPRGLISVVERQGKQGDAEQETISPPKKIQSVLWGKGGSLPSFPGVAAAAATAAAATGRLPRPSPRRKRVQEKKSLGGVSKPALGRTFPSWGRGISATPLDPATFPPISGIPLLGRSQKYASVPWGAKESKHTGAGKKSVARRARELVAATAVSGEDNDPNRDPVPKGQLATDRPWPSCPRVHHGEPSTANLSIRGGQDSGNSKPVAMNKGEVMPRGPGPSGDQKPADHHPRLKRRQQPPRRQGCPRCLVLQKEIDDLKEQLASMQYLAEKFRIL", "length": 534, "header": "sp|A5PKC7-1|CX049_BOVIN Isoform 1 of Uncharacterized protein CXorf49 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A5PKC7-1" }, "locus": { "chromosome": "NKLS02000966.1", "start_pos": 91808, "end_pos": 88207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086001.1", "url": "https://www.ensembl.org/id/ENSBTAT00000086001.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068571.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068571.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A5PKC7", "url": "https://www.uniprot.org/uniprotkb/A5PKC7" } ], "site_lbl": "Ser123" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A5PKC7", "url": "https://www.uniprot.org/uniprotkb/A5PKC7" } ], "site_lbl": "Ser87" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785476", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785476", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1B0GWI6-1", "protein_name": "Uncharacterized protein CXorf49C", "gene_name": "CXorf49C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSTDEVSVCRAGLGPEGGEQAGAHTASPGAPRGDGHGRDLNFGGQRSGKGKGKGESGFTDPESFSFESESELIEQGRVVLWGQEGRPGTPVDDQAGGGDYSFYLADEPATIMPPSSVQGHPSPEGATAKGSTDIWADLEVGPSWRGALSPSPGEWQQASAGPLHLSVPGPGPAWENPERGSKSRLSFQVDPQQPSAEGPAGLNTDDSDSADESSDLPVIRVIISTKEGSQAKPGSPKKPGDTCGRRSFHRRESYLQVQGPLLISPPRRLTPVVERPAVGELDVPSLKKMQSMVWGKRGVRPSCSGAAVRGPLPRGTLGRKVAQEKKSLEGAPELALRGAFPAWGQRLSAVPPDPASFPPVSGVGLLGKSVRPKEPKHSSPGKKPAGRKTRESQAAAREDNDPNRDEVPRAQLPTQKPELISLSVRRGEYSSGDPNIRAPQVLGTSQPSAFTLRRLVPRCHASSGDWQPPVHPPRPERQQQPPGAQGCPRCILLQREIEDLRDQLAAMQFLTDKFQDL", "length": 518 }, "evidence": [ { "id": "A5PKC7", "url": "https://omabrowser.org/oma/group/A5PKC7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3KR64-1", "protein_name": "Uncharacterized protein CXorf49 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSPEEQSVPGDDFNEESTDPNKNLSLVSGPADSNEGEIRLPSPKGSNLPLVSQQDTSEAPSVVLWTGGCWPDSLVSEEERLGSPEDEKMDGLDFLSQPSVETEQQVANPETPGAKEQPSSESFCAETETGSNRRAPQASGSEEAKAASAATFLPKGLEQSRAWVSPRKSTTSRMLISENVHHPPSEPELSEELNEVQMMRVTICLKDGNHGNQAKNSGPAETGDLARHSNVQTRESFMRMPSSLLTTTRGLTSGMERQTSKELEPFSSKKKQGILWGKGGSKSNYAEAAAGVGALPKAGPRKKMTQKKKPLWDASAVTLGKAFHQWGQRLKSAPAEPATFPPISGVGLPGRSNKCSLLPLRPKQCKNFYTGKRSGAKRTKELQLVAKEDTDSTRDPGSQVQFPTCRAEPPCQSVHQEFSSGDINTRSLQDPGNSQSSGLSQRGILSKKSTPSGDQEEPVGPPAPDSEILQLHGTQGCPRCPELQKEIEDLRKQLSALQAVGEKFQTHST", "length": 510 }, "evidence": [ { "id": "A5PKC7", "url": "https://omabrowser.org/oma/group/A5PKC7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D454-1", "protein_name": "Uncharacterized protein CXorf49 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSSEEQSVPGDDFYEESGDLNTGLSLVLRPAKSNEGESSLSSPKGSKLTLVSQLEASENPSVVLWAGEYCPDSLVPEEERVGSPMDEKVVGLDFLSQPSVETTATGQQVTNLETKGAREHPSPESVCAETEAGSIRRAPQASEEAKFAASAGTFFPKGLEQSRSWVTPRKSTTSRMVIGENVHHPTSEPEPLDELNEVQMMRVTICLKDGNHGNQAKNSGPAETGDLARHSNVQTRDSFMRMPSSLLVSTTRGLTSGVERQASKEPEPFSSKKKQGTLWGKGGSKSSYPEAAAGIGALPKASPRKKMAQKKKPLWDASAVTLGRAFHQWGQRLKSAPAEPATFPPISGVGLPGRSNKCSLLPLRPKQCKNLYTGKRSGAKKTKELQLVAKEDTDSTRDPSSQVQFPTHRAEPPCQSVHQEFNSGDINARSLQDAGNSQSSALNQRGIMSKKSVLSGDQEEPVGLPAPDSEILQLPGTQGCPRCPELQKEIEDLRKQLSALQAVSEKFQTHLS", "length": 513 }, "evidence": [ { "id": "A5PKC7", "url": "https://omabrowser.org/oma/group/A5PKC7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A5PKC7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 534, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A5PKC7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A5PKC7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 87, 123 ], "sequon_annotation_sites": [ { "start_pos": 450, "end_pos": 452 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC22-1", "uniprot_ac": "E1BC22", "uniprot_id": "E1BC22_BOVIN", "mass": { "chemical_mass": 17668.0, "monoisotopic_mass": 17668.0 }, "refseq": { "ac": "NP_001179967", "name": "cytosolic iron-sulfur assembly component 2B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179967" }, "gene_names": [ { "name": "CIAO2B", "type": "recommended", "evidence": [ { "id": "E1BC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC22" } ] }, { "name": "CIAO2B", "type": "synonym", "evidence": [ { "id": "NP_001179967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179967" } ] }, { "name": "FAM96B", "type": "synonym", "evidence": [ { "id": "NP_001179967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179967" } ] } ], "protein_names": [ { "name": "Cytosolic iron-sulfur assembly component 2B", "type": "recommended", "evidence": [ { "id": "E1BC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC22/entry#names_and_taxonomy" } ] }, { "name": "Mitotic spindle-associated MMXD complex subunit MIP18", "type": "synonym", "evidence": [ { "id": "E1BC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC22/entry#names_and_taxonomy" } ] }, { "name": "cytosolic iron-sulfur assembly component 2B", "type": "synonym", "evidence": [ { "id": "NP_001179967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179967" } ] }, { "name": "family with sequence similarity 96 member B", "type": "synonym", "evidence": [ { "id": "NP_001179967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179967" } ] } ], "function": [ { "annotation": "Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.", "evidence": [ { "database": "UniProtKB", "id": "E1BC22", "url": "https://www.uniprot.org/uniprotkb/E1BC22#function" }, { "database": "UniProtKB", "id": "ARBA00055145", "url": "https://www.uniprot.org/uniprotkb/ARBA00055145#function" }, { "database": "UniProtKB", "id": "A0A3Q1M9E3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9E3#function" }, { "database": "UniProtKB", "id": "A0AAA9TFA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFA9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC22", "url": "https://www.uniprot.org/uniprotkb/E1BC22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIAO2B", "url": "https://www.uniprot.org/uniprotkb/E1BC22", "locus": { "chromosome": "18", "start_pos": 34635125, "end_pos": 34637599, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013931", "url": "https://www.ensembl.org/id/ENSBTAG00000013931" } ] } } ], "crossref": [ { "id": "E1BC22", "url": "https://alphafold.ebi.ac.uk/entry/E1BC22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013931", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013931", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614585", "url": "https://www.ncbi.nlm.nih.gov/gene/614585", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002744", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002744", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614585", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614585", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12377:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12377:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01883", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01883", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179967", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9E3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9E3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9E3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC22", "url": "https://www.uniprot.org/uniprotkb/E1BC22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC22-1", "url": "https://www.uniprot.org/uniprotkb/E1BC22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGGGGMGGGLLENANPLIYERSGDRPVSAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS", "length": 163, "header": "tr|E1BC22-1|E1BC22_BOVIN Isoform 1 of Cytosolic iron-sulfur assembly component 2B OS=Bos taurus OX=9913 GN=CIAO2B PE=3 SV=2 CANONICAL=E1BC22-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9E3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9E3/entry", "sequence": { "sequence": "MELQVRVREVPKRSEPFRGRQASLGNCPAYGAGFSEEMMPGSISFGSSVLQPYPAVPSTLPARTSAPFSVPLLEALGMFPGPGGELMVATVPPIPQVEQEQRRVSLALPRHHATPHSRSPEVRRRRGSACLRSPAAVPRWWAAAAWGAVSWRTLTPSSTSALGTGQCPRARRTSRFQTASTRARSSISTAAGRGGGGRFSGAWDAGDEVTLCSRCSCVRAGHSGGGFSVGKGAESSFLHLAHLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS", "length": 357, "header": "tr|A0A3Q1M9E3-1|E1BC22_BOVIN Computationally mapped isoform of Cytosolic iron-sulfur assembly component 2B OS=Bos taurus OX=9913 GN=CIAO2B PE=3 SV=1 CANONICAL=E1BC22-1" }, "locus": { "chromosome": "18", "start_pos": 34637400, "end_pos": 34635243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066614.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066614.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065061.1" } ] } }, { "isoform_ac": "A0AAA9TFA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFA9/entry", "sequence": { "sequence": "MELQVEQEQRRVSLALPRHHATPHSRSPEVRRRRGSACLRSPAAVPRWWAAAAWGAVSWRTLTPSSTSALGTGQCPRARRTSRFQTASTRARSSISTAAGRGGGGRFSGAWDAGDEVTLCSRCSCVRAGHSGGGFSVGKGAESSFLHLAHLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS", "length": 265, "header": "tr|A0AAA9TFA9-1|E1BC22_BOVIN Computationally mapped isoform of Cytosolic iron-sulfur assembly component 2B OS=Bos taurus OX=9913 GN=CIAO2B PE=3 SV=1 CANONICAL=E1BC22-1" }, "locus": { "chromosome": "18", "start_pos": 34637400, "end_pos": 34635243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121491.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121491.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094838.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094838.1" } ] } }, { "isoform_ac": "E1BC22-1", "url": "https://www.uniprot.org/uniprotkb/E1BC22/entry", "sequence": { "sequence": "MVGGGGMGGGLLENANPLIYERSGDRPVSAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS", "length": 163, "header": "tr|E1BC22-1|E1BC22_BOVIN Isoform 1 of Cytosolic iron-sulfur assembly component 2B OS=Bos taurus OX=9913 GN=CIAO2B PE=3 SV=2 CANONICAL=E1BC22-1" }, "locus": { "chromosome": "18", "start_pos": 34636984, "end_pos": 34635243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018509.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018509.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018509.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018509.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614585", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614585", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic [4Fe-4S] assembly targeting complex", "id": "GO:0097361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097361", "evidence": [ { "database": "UniProtKB", "id": "E1BC22", "url": "https://www.uniprot.org/uniprotkb/E1BC22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "E1BC22", "url": "https://www.uniprot.org/uniprotkb/E1BC22" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "E1BC22", "url": "https://www.uniprot.org/uniprotkb/E1BC22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC22" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC22" }, { "id": "PF01883", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01883" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIP18 family-like", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 118, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA40-1", "uniprot_ac": "E1BA40", "uniprot_id": "E1BA40_BOVIN", "mass": { "chemical_mass": 46888.0, "monoisotopic_mass": 46888.0 }, "refseq": { "ac": "NP_001178184", "name": "SH2 domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178184" }, "gene_names": [ { "name": "SH2D5", "type": "recommended", "evidence": [ { "id": "E1BA40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA40" } ] }, { "name": "SH2D5", "type": "synonym", "evidence": [ { "id": "NP_001178184", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178184" } ] } ], "protein_names": [ { "name": "SH2 domain-containing protein 5", "type": "recommended", "evidence": [ { "id": "E1BA40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA40/entry#names_and_taxonomy" } ] }, { "name": "SH2 domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001178184", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178184" } ] } ], "function": [ { "annotation": "May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.", "evidence": [ { "database": "UniProtKB", "id": "E1BA40", "url": "https://www.uniprot.org/uniprotkb/E1BA40#function" }, { "database": "UniProtKB", "id": "ARBA00056636", "url": "https://www.uniprot.org/uniprotkb/ARBA00056636#function" }, { "database": "UniProtKB", "id": "A0A3Q1M9G0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9G0#function" }, { "database": "UniProtKB", "id": "A0AAA9S8M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA40", "url": "https://www.uniprot.org/uniprotkb/E1BA40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH2D5", "url": "https://www.uniprot.org/uniprotkb/E1BA40", "locus": { "chromosome": "2", "start_pos": 131914889, "end_pos": 131901690, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001082", "url": "https://www.ensembl.org/id/ENSBTAG00000001082" } ] } } ], "crossref": [ { "id": "E1BA40", "url": "https://alphafold.ebi.ac.uk/entry/E1BA40", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001082", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001082", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00173", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00173", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13157", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13157", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789769", "url": "https://www.ncbi.nlm.nih.gov/gene/789769", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789769", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789769", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDCGPEG", "url": "https://omabrowser.org/oma/group/QDCGPEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BA40", "url": "https://www.orthodb.org/?gene=E1BA40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15832", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15832", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15832:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15832:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178184", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9G0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9G0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA40", "url": "https://www.uniprot.org/uniprotkb/E1BA40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA40-1", "url": "https://www.uniprot.org/uniprotkb/E1BA40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKAGAGGRRASDCGPAPQRPRCITKFAQYVGSFPVDDLDPQESVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYATWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERARPEPCPEPVGDAPLKPVPGPGGPPGLVREPFGRDQLSQNVNALVSFRRLPAEGSGGSGKELLESASRGGTRHLRLGNPYCSPTLVRKKAIRSKVLRSGAYRACTYETQLQLSAREALPAAWEAWPRGPGGPSCLVESEGSLTENIWAFAGISRTSALALLRRDVLGAFLLWPEPGANGQWCLSVRTQCGVVPHQVFRNHVGRYCVEHLPAEFPSLEALVEHHAGTERSLFCSLDMGRLNPGYEEQDCGPSGQPPRTLRPLGHAKSEAELQGLG", "length": 428, "header": "tr|E1BA40-1|E1BA40_BOVIN Isoform 1 of SH2 domain-containing protein 5 OS=Bos taurus OX=9913 GN=SH2D5 PE=4 SV=2 CANONICAL=E1BA40-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9G0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9G0/entry", "sequence": { "sequence": "MQKAGAGGRRASDCGPAPQRPRCITKFAQYVGSFPVDDLDPQESVWLVQQQLWALKVLLMAHALRRILYATWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERARPEPCPEPVGDAPLKPVPGPGGPPGLVREPFGRDQLSQNVNALVSFRRLPAEGSGGSGKELLESASRGGTRHLRLGNPYCSPTLVRKKAIRSKVLRSGAYRACTYETQLQLSAREALPAAWEAWPRGPGGPSCLVESEGSLTENIWAFAGISRTSALALLRRDVLGAFLLWPEPGANGQWCLSVRTQCGVVPHQVFRNHVGRYCVEHLPAEFPSLEALVEHHAGTERSLFCSLDMGRLNPGYEEQDCGPSGQPPRTLRPLGHAKSEAELQGLG", "length": 403, "header": "tr|A0A3Q1M9G0-1|E1BA40_BOVIN Computationally mapped isoform of SH2 domain-containing protein 5 OS=Bos taurus OX=9913 GN=SH2D5 PE=4 SV=3 CANONICAL=E1BA40-1" }, "locus": { "chromosome": "2", "start_pos": 131913885, "end_pos": 131907373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069596.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069596.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065081.3", "url": "https://www.ensembl.org/id/ENSBTAP00000065081.3" } ] } }, { "isoform_ac": "A0AAA9S8M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M0/entry", "sequence": { "sequence": "MGQSGERFKEPPLHPSGKPAALGTMQKAGAGGRRASDCGPAPQRPRCITKFAQYVGSFPVDDLDPQESVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYATWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERARPEPCPEPVGDAPLKPVPGPGGPPGLVREPFGRDQLSQNVNALVSFRRLPAEGSGGSGKELLESASRGGTRHLRLGNPYCSPTLVRKKAIRSKVLRSGAYRACTYETQLQLSAREALPAAWEAWPRGPGGPSCLVESEGSLTENIWAFAGISRTSALALLRRDVLGAFLLWPEPGANGQWCLSVRTQCGVVPHQVFRNHVGRYCVEHLPAEFPSLEALVEHHAGTERSLFCSLDMGRLNPGYEEQDCGPSGQPPRTLRPLGHAKSEAELQGLG", "length": 452, "header": "tr|A0AAA9S8M0-1|E1BA40_BOVIN Computationally mapped isoform of SH2 domain-containing protein 5 OS=Bos taurus OX=9913 GN=SH2D5 PE=4 SV=1 CANONICAL=E1BA40-1" }, "locus": { "chromosome": "2", "start_pos": 131913885, "end_pos": 131901783, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107765.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107765.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081615.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081615.1" } ] } }, { "isoform_ac": "E1BA40-1", "url": "https://www.uniprot.org/uniprotkb/E1BA40/entry", "sequence": { "sequence": "MQKAGAGGRRASDCGPAPQRPRCITKFAQYVGSFPVDDLDPQESVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYATWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERARPEPCPEPVGDAPLKPVPGPGGPPGLVREPFGRDQLSQNVNALVSFRRLPAEGSGGSGKELLESASRGGTRHLRLGNPYCSPTLVRKKAIRSKVLRSGAYRACTYETQLQLSAREALPAAWEAWPRGPGGPSCLVESEGSLTENIWAFAGISRTSALALLRRDVLGAFLLWPEPGANGQWCLSVRTQCGVVPHQVFRNHVGRYCVEHLPAEFPSLEALVEHHAGTERSLFCSLDMGRLNPGYEEQDCGPSGQPPRTLRPLGHAKSEAELQGLG", "length": 428, "header": "tr|E1BA40-1|E1BA40_BOVIN Isoform 1 of SH2 domain-containing protein 5 OS=Bos taurus OX=9913 GN=SH2D5 PE=4 SV=2 CANONICAL=E1BA40-1" }, "locus": { "chromosome": "2", "start_pos": 131913885, "end_pos": 131907373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001431.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001431.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001431.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001431.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789769", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789769", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A096MJ64-1", "protein_name": "SH2 domain-containing protein 5", "gene_name": "Sh2d5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRAGAGARRASDCGPAPYRPRCIAKFAQYVGSFPVDDLDTQESVCLVQQHLWALQDCSRRRAVILKFSLQGLKIYSGEGEVLLMAHALKRILYATWNPAACQFAFVARNPRSPASKLFCHLFVGSQPGEINILYLLLCRSFQLAYLLQHPEERAQPEPSLVPGGDMSLKPLCSPGVAPALVREPFSRDQLSQNVHALVSFRRLPAEGLLGSNGKELPEPEGRGGTRHIRLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGSPSCLVENEGSLTENIWAFAGLSRSCALALLRRDVHGAFLLWPEPGTSGQWSLSVRTQCGVVSHQVFRNHLGRYCLEHLPAEFPSLEALVESHAGMERSLFCPLSMGRLNPTYEEQDSGPEGRFPRTLRPLSHAKSEAELQGLG", "length": 429 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A3L7I8M5-1", "protein_name": "SH2 domain-containing protein 5", "gene_name": "Sh2d5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQRAGAGARRASDCGPAPYRPRCIAKFAQYVGSFPVEDLDTQEGVYLVQQQLWALQDCSRRRAVILKFSLQGLKVYSGEGEVLLMAHALKRILYATWCPAACQFAFVARNPRSPASKLYCHLFVGSQPGEVHILYLLLCRSFQLAYLLQHPEERAQPEPCLGPMGDMSPKPLCSPGTPPVLVREPFSRDQLSQNVHALVSFRRVPAEGLLGGSGKELPEPEGRGGPRHTRLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRSPGGPSCLVENEGSLTENIWAFAGLSKPCALALLRRDVHGAFLLWPEPGTSDQWSLSVRTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVESHAGMERSLFCPLSMGRLNPTYEEQDCGPEGRLPRTLRPLSHAKSEAELQGLG", "length": 429 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZNL1-1", "protein_name": "SH2 domain containing 5", "gene_name": "SH2D5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKKKMTANGRGPDPAPPPPRARGIAKSAEYVGSFMVEELELQQHVGQLEEQLRALKDCPRRRSVVLRFSLQGLKVYGDDGETLLMAHALRRILYSTCLHAERQFAFVARNPHSPPSTLFCHLFVSPVGEVHVLHLLLCRSFQLCYLQAHPELQAAEPDPPVLLRETLNPEEVSRNVNALLSLRRLPALGPLGAGHVFAQHLLQERRVEAEGRAVGWRPGNPYCSPVLVRKKAIRSKVLRSGAYRDCGAESQLQQREGGIGFGALKEDPGGQERDLGPDTHPPPSAPSGWESRGMRGLVLLPDTEAALAESVWAFAGIARASGIALLRGDVPGAFLLRPEPGATPRWCLWVHTPCGVVPYCVLRTQQGRFCVEHSHAEFRSMPALLAHYSAVPGGCFCRLSVGRCNPGYEQRDEDGPALVQHERG", "length": 424 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1Q5B0-1", "protein_name": "SH2 domain-containing protein 5 isoform 1", "gene_name": "sh2d5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFKRQTPQPGSVWNMGETAGREHGTVTRSAEYIGSFPVDDSCLDDQIQQLHTQLKSLKNCKSKRTVSLRFSVKGVKVYDEDETTLLMAHAMCRVSLSTARPSDAQFAFASHNPGNSDAQLYCHLFRARHARAAQFLNLLLCRCFQLYFLEKHPEEAQEECSGKKPSRAPSLLNQGFPLSVSALVSFRRAPTQGLLPGAKLFSQQSTEQVSSPEEGPTSSPTIVRKMAIRTKELRSGAYRSFTFTPLKQRHLQDKLSAPQEKEQATAKACMSRAPSLAETEEALAQAVWCWAGVSSDCSSSLLADDVLGAFLLCPHPKKPNRGSLIVRFSSGLVTYAIKNSKGKFRLEKCHTDFESLAALMEHYTEFGDELECSLSCARVNHCYDWEEMVNKGSRLLQDNKKGTFKCRSWV", "length": 410 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SU08-1", "protein_name": "SH2 domain-containing protein 5", "gene_name": "SH2D5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQKAGAGGRRASDCGPAPHRPRCITKFAQYVGSFPVDDLDTQERVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYTTWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCLGPAGDVALKPLSCPGGPSGLVREPFGRDQLSQNVNALVSFRRLPAEGPGGSGKELPESESRGGARHTRLGNPYCSPTLVRKKAIRSKVIRSGAYRACTYETQLQLSAREAFPALWEAWPRGPGSPSCLVESEGSLTENIWAFAGISRPSALALLRRDVLGAFLLWPEPGANGQWCLSVRTQCGVVPHQVFRNHLGRYCVEHLPAEFPSLEALVEHHAGTERSLFCSLDMGRLNPN", "length": 396 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6ZV89-1", "protein_name": "SH2 domain-containing protein 5", "gene_name": "SH2D5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQESVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQGLG", "length": 423 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8JZW5-1", "protein_name": "SH2 domain-containing protein 5", "gene_name": "Sh2d5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRAGAGARRASDCGPAPYRPRCIAKLAQYVGSFPVDDLDTQESVGLVQQQLWALQDCSRRRAVILKFSLQGLKIYSGEGEVLLMAHALKRILYATWYPAACQFAFIARNPRSPSSKLFCHLFVGSQPGEVHILYLLLCRSFQLAYLLQHPEERAQSEPCLAPVGDLSLKPLCSPGVPPALVREPFSRDQLSQNVHALVSFRRLPAEGLLGSNGKELPESEGRGGTRHIRLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGPSCLVENEGSLTENIWAFAGLSRSCALSLLRRDVHGAFLLWPEPGTSDQWSLSVRTQCGVVPHQVFRNHLGRFCLEHLPAEFPSLEALVESHAGVERSLFCPLSMGRLNPTYEEQDCGTEGRFPRTLRPLSHAKSEAELQGLG", "length": 429 }, "evidence": [ { "id": "E1BA40", "url": "https://omabrowser.org/oma/group/E1BA40/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "E1BA40", "url": "https://www.uniprot.org/uniprotkb/E1BA40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA40-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 428, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA40-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA40" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA40" }, { "id": "PS01179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PID", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 146, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BA40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA40" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 301, "end_pos": 397, "start_aa": "Trp", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9S5-1", "uniprot_ac": "E1B9S5", "uniprot_id": "E1B9S5_BOVIN", "mass": { "chemical_mass": 86927.0, "monoisotopic_mass": 86927.0 }, "refseq": { "ac": "NP_001180002", "name": "myotubularin-related protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180002" }, "gene_names": [ { "name": "MTMR10", "type": "recommended", "evidence": [ { "id": "E1B9S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S5" } ] }, { "name": "MTMR10", "type": "synonym", "evidence": [ { "id": "NP_001180002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180002" } ] } ], "protein_names": [ { "name": "Myotubularin-related protein 10", "type": "recommended", "evidence": [ { "id": "E1B9S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S5/entry#names_and_taxonomy" } ] }, { "name": "Inactive phosphatidylinositol 3-phosphatase 10", "type": "synonym", "evidence": [ { "id": "E1B9S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S5/entry#names_and_taxonomy" } ] }, { "name": "myotubularin-related protein 10", "type": "synonym", "evidence": [ { "id": "NP_001180002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180002" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9S5", "url": "https://www.uniprot.org/uniprotkb/E1B9S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTMR10", "url": "https://www.uniprot.org/uniprotkb/E1B9S5", "locus": { "chromosome": "21", "start_pos": 27438000, "end_pos": 27474950, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014422", "url": "https://www.ensembl.org/id/ENSBTAG00000014422" } ] } } ], "crossref": [ { "id": "E1B9S5", "url": "https://alphafold.ebi.ac.uk/entry/E1B9S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014422", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014422", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13346", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13346", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615443", "url": "https://www.ncbi.nlm.nih.gov/gene/615443", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615443", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615443", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M9U6", "url": "https://www.orthodb.org/?gene=A0A3Q1M9U6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9S5", "url": "https://www.orthodb.org/?gene=E1B9S5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10807", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10807", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10807:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10807:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12578", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12578", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9U6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9U6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9S5", "url": "https://www.uniprot.org/uniprotkb/E1B9S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9S5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9S5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSLKPPRPTFRSYLLPPPQTDDKINSEPKIKKLEPVLLPGEIVVNEVNFVRKCIASDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEHDVPLTCIEQIVTLNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSASKANGAPLGAGGGGSQKTPLFETYSDWDREVKRTGASGWRVCSINEGYMISTCLPEYFVVPSSLADQDLKVFSHSFVGRRMPFWCWSHSNGSALVRTALIRDVLQQRKIEQRICNAITKSHPQRNDVYKSDLDKTLPNIQDIQVAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHAAELVYVLESKRLSVVLQEEEGRDLSCIIASLVQVMLDPYFRTITGFQSLIQKEWVMAGYPFLDRCNHLKRSEKEAPVFLLFLDTTWQLLEQCPAAFEFSETYLAVLHDSTRVALFGTFLFNSPHQRVQQSTEFAISKNIQLGDEKGLKFPSVWDWSLQFTPKDRTLFHNPFYIGKSTPCVQNGSVKSFKRTKKSYSSTLRGMPASLKNGIISEEELRPRRNSLILQVKPAPLETRDSQDWGAERFFQERASRPADLHGTILPHLSGAHIKLWKLCYFRWVPEAQIQHGGFITAFHKLSLLADEVDVLSRALRQPRGGPMPAPGPELAPSRLYFCAGGPHDAPGTPDFLSSSFPFSPVGNLCRRSISGTPLSKFLSGAKIWLSTETLANED", "length": 764, "header": "tr|E1B9S5-1|E1B9S5_BOVIN Isoform 1 of Myotubularin-related protein 10 OS=Bos taurus OX=9913 GN=MTMR10 PE=3 SV=2 CANONICAL=E1B9S5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9U6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U6/entry", "sequence": { "sequence": "MFSLKPPRPTFRSYLLPPPQTDDKINSEPKIKKLEPVLLPGEIVVNEVNFVRKCIASDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEHDVPLTCIEQIVTLNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSGLSLWSHLRKYLFYSRFTSKANGAPLGAGGGGSQKTPLFETYSDWDREVKRTGASGWRVCSINEGYMISTCLPEYFVVPSSLADQDLKVFSHSFVGRRMPFWCWSHSNGSALVRTALIRDVLQQRKIEQRICNAITKSHPQRNDVYKSDLDKTLPNIQDIQVAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHAAELVYVLESKRLSVVLQEEEGRDLSCIIASLVQVMLDPYFRTITGFQSLIQKEWVMAGYPFLDRCNHLKRSEKEAPVFLLFLDTTWQLLEQCPAAFEFSETYLAVLHDSTRVALFGTFLFNSPHQRVQQSTEFAISKNIQLGDEKGLKFPSVWDWSLQFTPKDRTLFHNPFYIGKSTPCVQNGSVKSFKRTKKSYSSTLRGMPASLKNGIISEEELRPRRNSLILQVKPAPLETRDSQDWGAERFFQERASRPADLHGTILPHLSGAHIKLWKLCYFRWVPEAQIQHGGFITAFHKLSLLADEVDVLSRALRQPRGGPMPAPGPELAPSRLYFCAGGPHDAPGTPDFLSSSFPFSPVGNLCRRSISGTPLSKFLSGAKIWLSTETLANED", "length": 781, "header": "tr|A0A3Q1M9U6-1|E1B9S5_BOVIN Computationally mapped isoform of Myotubularin-related protein 10 OS=Bos taurus OX=9913 GN=MTMR10 PE=3 SV=2 CANONICAL=E1B9S5-1" }, "locus": { "chromosome": "21", "start_pos": 27474751, "end_pos": 27438640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066960.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066960.2" } ] } }, { "isoform_ac": "E1B9S5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9S5/entry", "sequence": { "sequence": "MFSLKPPRPTFRSYLLPPPQTDDKINSEPKIKKLEPVLLPGEIVVNEVNFVRKCIASDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEHDVPLTCIEQIVTLNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSASKANGAPLGAGGGGSQKTPLFETYSDWDREVKRTGASGWRVCSINEGYMISTCLPEYFVVPSSLADQDLKVFSHSFVGRRMPFWCWSHSNGSALVRTALIRDVLQQRKIEQRICNAITKSHPQRNDVYKSDLDKTLPNIQDIQVAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHAAELVYVLESKRLSVVLQEEEGRDLSCIIASLVQVMLDPYFRTITGFQSLIQKEWVMAGYPFLDRCNHLKRSEKEAPVFLLFLDTTWQLLEQCPAAFEFSETYLAVLHDSTRVALFGTFLFNSPHQRVQQSTEFAISKNIQLGDEKGLKFPSVWDWSLQFTPKDRTLFHNPFYIGKSTPCVQNGSVKSFKRTKKSYSSTLRGMPASLKNGIISEEELRPRRNSLILQVKPAPLETRDSQDWGAERFFQERASRPADLHGTILPHLSGAHIKLWKLCYFRWVPEAQIQHGGFITAFHKLSLLADEVDVLSRALRQPRGGPMPAPGPELAPSRLYFCAGGPHDAPGTPDFLSSSFPFSPVGNLCRRSISGTPLSKFLSGAKIWLSTETLANED", "length": 764, "header": "tr|E1B9S5-1|E1B9S5_BOVIN Isoform 1 of Myotubularin-related protein 10 OS=Bos taurus OX=9913 GN=MTMR10 PE=3 SV=2 CANONICAL=E1B9S5-1" }, "locus": { "chromosome": "21", "start_pos": 27474751, "end_pos": 27438640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019182.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019182.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019182.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019182.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615443", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615443", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S5" }, { "id": "PS51339", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51339" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myotubularin phosphatase", "eco_id": "ECO_0000259", "start_pos": 210, "end_pos": 650, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 279, "end_pos": 281 }, { "start_pos": 556, "end_pos": 558 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A7YW81-1", "uniprot_ac": "A7YW81", "uniprot_id": "TM234_BOVIN", "mass": { "chemical_mass": 15020.0, "monoisotopic_mass": 15020.0 }, "refseq": { "ac": "NP_001099124", "name": "transmembrane protein 234 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099124" }, "gene_names": [ { "name": "TMEM234", "type": "recommended", "evidence": [ { "id": "A7YW81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YW81" } ] }, { "name": "TMEM234", "type": "synonym", "evidence": [ { "id": "NP_001099124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099124" } ] } ], "protein_names": [ { "name": "Transmembrane protein 234", "type": "recommended", "evidence": [ { "id": "A7YW81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YW81/entry#names_and_taxonomy" } ] }, { "name": "UPF0546 membrane protein C1orf91 homolog", "type": "synonym", "evidence": [ { "id": "NP_001099124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099124" } ] }, { "name": "transmembrane protein 234 precursor", "type": "synonym", "evidence": [ { "id": "NP_001099124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099124" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YW81", "url": "https://www.uniprot.org/uniprotkb/A7YW81" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM234", "url": "https://www.uniprot.org/uniprotkb/A7YW81", "locus": { "chromosome": "2", "start_pos": 121311470, "end_pos": 121305656, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009163", "url": "https://www.ensembl.org/id/ENSBTAG00000009163" } ] } } ], "crossref": [ { "id": "A7YW81", "url": "https://alphafold.ebi.ac.uk/entry/A7YW81", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009163", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009163", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100126052", "url": "https://www.ncbi.nlm.nih.gov/gene/100126052", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018908", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018908", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100126052", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100126052", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LGEWYAE", "url": "https://omabrowser.org/oma/group/LGEWYAE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7YW81", "url": "https://www.orthodb.org/?gene=A7YW81", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28668", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28668", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28668:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28668:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001099124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099124", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC09", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YW81", "url": "https://www.uniprot.org/uniprotkb/A7YW81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YW81-1", "url": "https://www.uniprot.org/uniprotkb/A7YW81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATLGQVLALVLVAALWGGTQPLLKRASSRLQQVHERTWARQLLQEMKTLFLNPEYLMPFSLNQCGSLLYYLTLASTDLTLAVPISNSLAIIFTLIVGKVLGEDIGGKRAFAGMVLTVAGITLCITSSVTKTQGQPSAL", "length": 140, "header": "sp|A7YW81-1|TM234_BOVIN Isoform 1 of Transmembrane protein 234 OS=Bos taurus OX=9913 GN=TMEM234 PE=2 SV=1 CANONICAL=A7YW81-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC09/entry", "sequence": { "sequence": "MAATLGKRAPPLPWLPDRYPKFISYTPSPPNPDPCYKPEPGLQDPSPRLRGACPTRQSHTGRRKAKKGCRGGGARMGGRRRAKAVRWGGGGCHSYLHPGQVLALVLVAALWGGTQPLLKRASSRLQQVHERTWARQLLQEMKTLFLNPEYLMPFSLNQCGSLLYYLTLASTDLTLAVPISNSLAIIFTLIVGKVLGEDIGGKRAFAGMVLTVAGITLCITSSVTKTQGQPSAL", "length": 233, "header": "tr|A0A3Q1MC09-1|TM234_BOVIN Computationally mapped isoform of Transmembrane protein 234 OS=Bos taurus OX=9913 GN=TMEM234 PE=2 SV=1 CANONICAL=A7YW81-1" }, "locus": { "chromosome": "2", "start_pos": 121310794, "end_pos": 121306106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071491.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071491.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066262.1" } ] } }, { "isoform_ac": "A0AAA9THA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA2/entry", "sequence": { "sequence": "MAATLDLTLAVPISNSLAIIFTLIVGKVLGEDIGGKRAFAGMVLTVAGITLCITSSVTKTQGQPSAL", "length": 67, "header": "tr|A0AAA9THA2-1|TM234_BOVIN Computationally mapped isoform of Transmembrane protein 234 OS=Bos taurus OX=9913 GN=TMEM234 PE=2 SV=1 CANONICAL=A7YW81-1" }, "locus": { "chromosome": "2", "start_pos": 121310794, "end_pos": 121306106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129804.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129804.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095600.1" } ] } }, { "isoform_ac": "A0AAA9TIK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK0/entry", "sequence": { "sequence": "MDRSWPCSKIGFCGDRTAVSAPRIGPCPSPDPHGNTFNTEELTIPAVTRGKQQRQVLALVLVAALWGGTQPLLKRASSRLQQVHERTWARQLLQEMKTLFLNPEYLMPFSLNQCGSLLYYLTLASTDLTLAVPISNSLAIIFTLIVGKVLGEDIGGKRAFAGMVLTVAGITLCITSSVTKTQGQPSAL", "length": 188, "header": "tr|A0AAA9TIK0-1|TM234_BOVIN Computationally mapped isoform of Transmembrane protein 234 OS=Bos taurus OX=9913 GN=TMEM234 PE=2 SV=1 CANONICAL=A7YW81-1" }, "locus": { "chromosome": "2", "start_pos": 121310794, "end_pos": 121305855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090609.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090609.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098134.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098134.1" } ] } }, { "isoform_ac": "A7YW81-1", "url": "https://www.uniprot.org/uniprotkb/A7YW81/entry#A7YW81-1", "sequence": { "sequence": "MAATLGQVLALVLVAALWGGTQPLLKRASSRLQQVHERTWARQLLQEMKTLFLNPEYLMPFSLNQCGSLLYYLTLASTDLTLAVPISNSLAIIFTLIVGKVLGEDIGGKRAFAGMVLTVAGITLCITSSVTKTQGQPSAL", "length": 140, "header": "sp|A7YW81-1|TM234_BOVIN Isoform 1 of Transmembrane protein 234 OS=Bos taurus OX=9913 GN=TMEM234 PE=2 SV=1 CANONICAL=A7YW81-1" }, "locus": { "chromosome": "2", "start_pos": 121310794, "end_pos": 121306106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012078.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012078.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012078.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012078.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100126052", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100126052", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1Z7W3-1", "protein_name": "Transmembrane protein 234 homolog", "gene_name": "Dmel\\CG12929", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLDIAAQLLAVGLLWGVTNPFIRLGSQGIESVGDTGSKWRNFVQEARTIGSRWRYWIPFGLNQCGSALYVWTLQRASITVAVPVANSLSFAFTAITGYALGEKLPGRKVILGTLLVCCGSILMIYDKILQEQAQHQLNITFH", "length": 142 }, "evidence": [ { "id": "A7YW81", "url": "https://omabrowser.org/oma/group/A7YW81/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "B8A4M2-1", "protein_name": "Transmembrane protein 234 isoform 1 precursor", "gene_name": "tmem234", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVSTSEVFCLLLVAILWGGTNPFLKKGTEGIEEVQKKNKLLQFLAELKFLFLNFKYLVPFLLNQSGSLVFYFTLASTDLSLAVPVVNSLTFLFTLLMGKVLGEEFGGKGAIMGMLLIMCGVTVCVLSSVSETHGIGARNISET", "length": 143 }, "evidence": [ { "id": "A7YW81", "url": "https://omabrowser.org/oma/group/A7YW81/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54ZG7-1", "protein_name": "Transmembrane protein 234 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDTYNIISLLLVGFIWGGTNPLIKRGSEGVSKVKKDNFLSQIIYEFVYLWTRPSYTIPMLINLSGSVVFFYTLSKVDISLVVPISNSLTFLFTSLMGMLLGEKVLHFKSYLGMIFVLAGVTICVSSKF", "length": 128 }, "evidence": [ { "id": "A7YW81", "url": "https://omabrowser.org/oma/group/A7YW81/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8R1E7-1", "protein_name": "Transmembrane protein 234", "gene_name": "Tmem234", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASWGQVLALVLVAALWGGTQPLLKRASSGLEQVRERTWAWQLLQEIKALFGNTEYLMPFLLNQSGSLLYYLTLASTDLTLAVPICNSLAIVFTLIVGKVLGEDIGGKEAVAGMVLTITGITVCITSSVSKTQGQPSHS", "length": 140 }, "evidence": [ { "id": "A7YW81", "url": "https://omabrowser.org/oma/group/A7YW81/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WY98-1", "protein_name": "Transmembrane protein 234", "gene_name": "TMEM234", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASLGQVLALVLVAALWGGTQPLLKRASAGLQRVHEPTWAQQLLQEMKTLFLNTEYLMPFLLNQCGSLLYYLTLASTDLTLAVPICNSLAIIFTLIVGKALGEDIGGKRAVAGMVLTVIGISLCITSSVPWTAELQLHGKGQLQTLSQKCKREASGTQSERFG", "length": 164 }, "evidence": [ { "id": "A7YW81", "url": "https://omabrowser.org/oma/group/A7YW81/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A7YW81", "url": "https://www.uniprot.org/uniprotkb/A7YW81" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YW81-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 140, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YW81-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YW81" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B893-1", "uniprot_ac": "E1B893", "uniprot_id": "E1B893_BOVIN", "mass": { "chemical_mass": 75536.0, "monoisotopic_mass": 75536.0 }, "refseq": { "ac": "XP_024834846", "name": "protein Smaug homolog 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834846" }, "gene_names": [ { "name": "SAMD4B", "type": "recommended", "evidence": [ { "id": "E1B893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ] }, { "name": "SAMD4B", "type": "synonym", "evidence": [ { "id": "XP_024834846", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834846" } ] } ], "protein_names": [ { "name": "Sterile alpha motif domain containing 4B", "type": "synonym", "evidence": [ { "id": "E1B893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B893/entry#names_and_taxonomy" } ] }, { "name": "protein Smaug homolog 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024834846", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834846" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAMD4B", "url": "https://www.uniprot.org/uniprotkb/E1B893", "locus": { "chromosome": "18", "start_pos": 49091910, "end_pos": 49063544, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009785", "url": "https://www.ensembl.org/id/ENSBTAG00000009785" } ] } } ], "crossref": [ { "id": "E1B893", "url": "https://alphafold.ebi.ac.uk/entry/E1B893", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009785", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009785", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09557", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09557", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509172", "url": "https://www.ncbi.nlm.nih.gov/gene/509172", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509172", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509172", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PFGDHAP", "url": "https://omabrowser.org/oma/group/PFGDHAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B893", "url": "https://www.orthodb.org/?gene=E1B893", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12515:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12515:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26034", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26034", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834846", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834846", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC91", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B893-1", "url": "https://www.uniprot.org/uniprotkb/E1B893-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEDRLASGFRTRPEPTYHSRQGSDEWGGPAELGPGDAGPAWQDKPPRENGHVPFHPPSSVPPAINSIGSNANAGLPCQIHPSPLKRSMSLIPTSPQTPGEWPSPEELGARAVFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAATAATTSTAKDGGRGEPPLPGAEPPLALPGTDKGSETNDPPAAESYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLSHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGISPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI", "length": 695, "header": "tr|E1B893-1|E1B893_BOVIN Isoform 1 of Sterile alpha motif domain containing 4B OS=Bos taurus OX=9913 GN=SAMD4B PE=3 SV=3 CANONICAL=E1B893-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC91/entry", "sequence": { "sequence": "MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEDRLASGFRTRPEPTYHSRQGSDEWGGPAELGPGDAGPAWQDKPPRENGHVPFHPPSSVPPAINSIGSNANAGLPCQIHPSPLKRSMSLIPTSPQTPGEWPSPEELGARAVFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAATAATTSTAKDGGRGEPPLPGAEPPLALPGTDKGSETNDPPAAESYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLSHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGISPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGGIGDELRVEGDVREAVAVLDSADHSRPGNTVAQNLAPAALPLRPAPLGPPVLGKHDGAHLSGKVR", "length": 751, "header": "tr|A0A3Q1MC91-1|E1B893_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 4B OS=Bos taurus OX=9913 GN=SAMD4B PE=3 SV=1 CANONICAL=E1B893-1" }, "locus": { "chromosome": "18", "start_pos": 49090906, "end_pos": 49063743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068763.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068763.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071713.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071713.2" } ] } }, { "isoform_ac": "E1B893-1", "url": "https://www.uniprot.org/uniprotkb/E1B893/entry", "sequence": { "sequence": "MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEDRLASGFRTRPEPTYHSRQGSDEWGGPAELGPGDAGPAWQDKPPRENGHVPFHPPSSVPPAINSIGSNANAGLPCQIHPSPLKRSMSLIPTSPQTPGEWPSPEELGARAVFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAATAATTSTAKDGGRGEPPLPGAEPPLALPGTDKGSETNDPPAAESYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLSHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGISPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI", "length": 695, "header": "tr|E1B893-1|E1B893_BOVIN Isoform 1 of Sterile alpha motif domain containing 4B OS=Bos taurus OX=9913 GN=SAMD4B PE=3 SV=3 CANONICAL=E1B893-1" }, "locus": { "chromosome": "18", "start_pos": 49084218, "end_pos": 49063743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006301.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006301.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006301.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006301.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 457, "start_aa": "Thr", "end_pos": 457, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr457", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509172", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509172", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1W2Q6J6-1", "protein_name": "Sterile alpha motif domain containing 4B", "gene_name": "Samd4b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMFRDQVGILASWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRTRPEPSYHSRQGSDEWGGPAELAPGEAGSGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLIPTSPQAPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATPTAKDGGRGEPLLPGAEPPLTHPGSDKGTEAKDPPAAENYPPPPAPAPSDSSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALDMQSYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDFDESCCPEPDSEH", "length": 692 }, "evidence": [ { "id": "E1B893", "url": "https://omabrowser.org/oma/group/E1B893/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5PRF9-1", "protein_name": "Protein Smaug homolog 2", "gene_name": "SAMD4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRSRPEPSYHSRQGSDEWGGPAELGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLIPTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI", "length": 694 }, "evidence": [ { "id": "E1B893", "url": "https://omabrowser.org/oma/group/E1B893/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80XS6-1", "protein_name": "Protein Smaug homolog 2", "gene_name": "Samd4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMFRDQVGILASWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRTRPEPSYHSRQGSDEWGGPAELAPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLIPTSPQAPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLWNALQELQQIIITPIKAYSVLQATPTAKDEGRGEPLLPGAEPPLTHPGSDKGTEAKDPPAAENYPPPPAPAPSDSSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALDMQSYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI", "length": 687 }, "evidence": [ { "id": "E1B893", "url": "https://omabrowser.org/oma/group/E1B893/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" }, { "name": "translation repressor activity", "id": "GO:0030371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030371", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of mRNA stability", "id": "GO:0043488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043488", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA poly(A) tail shortening", "id": "GO:0000289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000289", "evidence": [ { "database": "UniProtKB", "id": "E1B893", "url": "https://www.uniprot.org/uniprotkb/E1B893" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B893-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 695, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B893-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B893" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 457 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 340, "end_pos": 342 }, { "start_pos": 496, "end_pos": 498 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9H1-1", "uniprot_ac": "E1B9H1", "uniprot_id": "E1B9H1_BOVIN", "mass": { "chemical_mass": 71720.0, "monoisotopic_mass": 71720.0 }, "refseq": {}, "gene_names": [ { "name": "TINAGL1", "type": "recommended", "evidence": [ { "id": "E1B9H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ] } ], "protein_names": [ { "name": "Tubulointerstitial nephritis antigen like 1", "type": "synonym", "evidence": [ { "id": "E1B9H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TINAGL1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1", "locus": { "chromosome": "2", "start_pos": 122142701, "end_pos": 122154279, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013235", "url": "https://www.ensembl.org/id/ENSBTAG00000013235" } ] } } ], "crossref": [ { "id": "E1B9H1", "url": "https://alphafold.ebi.ac.uk/entry/E1B9H1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013235", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013235", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02620", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02620", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9H1", "url": "https://www.orthodb.org/?gene=E1B9H1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MCV8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCV8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9H1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGGLSRWCLFHSPAVKSPLAPGPTFGRQGIAQWGGPKLGTPPPPNLPLSAQAPRPHREAHRAVLPRVSRPLNVSTSVGAGPLRERLPAETRQGESRAHDPFPQVPASGVTAGRFQVRTRWGPSLPPPAGAARPAGRYKKRSRPAQLSSLDFECPAAVAGSGEAEAREAAGLSPHPSPGGTMWRRPLGLLLLLLLLLAGELGVGARRGRRRRELAPALHRRGIRDAGGRYCQEQDLCCRGRADDCALPYLGVTCYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHKGRIYPVLGTYWDNCNRCTCHEKERWECDQEPCLVDEDMIEAINHGDYGWRAGNHSAFWGMTLDEGIRYRLGTVRPSSFVANMNEIHTVLGPGEVLPRTFEASEKWPNLIHDPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMSPVLSPQNLLSCDTHNQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGHGRDEAVPAPPCMMHSRAMGRGKRQATARCPNSYVHANDIYQVTPAYRLGSNEKEIMKELMENGPVQALMEVHEDFFLYQSGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPAWGERGHFRIVRGANECDIESFVLGVWGRVGMEDMGHH", "length": 650, "header": "tr|E1B9H1-1|E1B9H1_BOVIN Isoform 1 of Tubulointerstitial nephritis antigen like 1 OS=Bos taurus OX=9913 GN=TINAGL1 PE=3 SV=2 CANONICAL=E1B9H1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCV8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCV8/entry", "sequence": { "sequence": "MWRRPLGLLLLLLLLLAGELGVGARRGRRRRELAPALHRRGIRDAGGRYCQEQDLCCRGRADDCALPYLGVTCYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHKGRIYPVLGTYWDNCNRCWRAGNHSAFWGMTLDEGIRYRLGTVRPSSFVANMNEIHTVLGPGEVLPRTFEASEKWPNLIHDPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMSPVLSPQNLLSCDTHNQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGHGRDEAVPAPPCMMHSRAMGRGKRQATARCPNSYVHANDIYQVTPAYRLGSNEKEIMKELMENGPVQALMEVHEDFFLYQSGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPAWGERGHFRIVRGANECDIESFVLGVWGRVGMEDMGHH", "length": 438, "header": "tr|A0A3Q1MCV8-1|E1B9H1_BOVIN Computationally mapped isoform of Tubulointerstitial nephritis antigen like 1 OS=Bos taurus OX=9913 GN=TINAGL1 PE=3 SV=1 CANONICAL=E1B9H1-1" }, "locus": { "chromosome": "2", "start_pos": 122152411, "end_pos": 122143070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086097.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086097.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068217.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068217.2" } ] } }, { "isoform_ac": "E1B9H1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1/entry", "sequence": { "sequence": "MGGGLSRWCLFHSPAVKSPLAPGPTFGRQGIAQWGGPKLGTPPPPNLPLSAQAPRPHREAHRAVLPRVSRPLNVSTSVGAGPLRERLPAETRQGESRAHDPFPQVPASGVTAGRFQVRTRWGPSLPPPAGAARPAGRYKKRSRPAQLSSLDFECPAAVAGSGEAEAREAAGLSPHPSPGGTMWRRPLGLLLLLLLLLAGELGVGARRGRRRRELAPALHRRGIRDAGGRYCQEQDLCCRGRADDCALPYLGVTCYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHKGRIYPVLGTYWDNCNRCTCHEKERWECDQEPCLVDEDMIEAINHGDYGWRAGNHSAFWGMTLDEGIRYRLGTVRPSSFVANMNEIHTVLGPGEVLPRTFEASEKWPNLIHDPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMSPVLSPQNLLSCDTHNQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGHGRDEAVPAPPCMMHSRAMGRGKRQATARCPNSYVHANDIYQVTPAYRLGSNEKEIMKELMENGPVQALMEVHEDFFLYQSGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPAWGERGHFRIVRGANECDIESFVLGVWGRVGMEDMGHH", "length": 650, "header": "tr|E1B9H1-1|E1B9H1_BOVIN Isoform 1 of Tubulointerstitial nephritis antigen like 1 OS=Bos taurus OX=9913 GN=TINAGL1 PE=3 SV=2 CANONICAL=E1B9H1-1" }, "locus": { "chromosome": "2", "start_pos": 122154056, "end_pos": 122143070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038022.5", "url": "https://www.ensembl.org/id/ENSBTAT00000038022.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037841.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037841.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 524, "start_aa": "Thr", "end_pos": 524, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr524", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "pmid": "" }, { "name": "laminin binding", "id": "GO:0043236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043236", "evidence": [ { "database": "UniProtKB", "id": "E1B9H1", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9H1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 650, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9H1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9H1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H1" }, { "id": "PS50958", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50958" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SMB", "eco_id": "ECO_0000259", "start_pos": 233, "end_pos": 281, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25, 524 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Y4-1", "uniprot_ac": "F1N0Y4", "uniprot_id": "F1N0Y4_BOVIN", "mass": { "chemical_mass": 64270.0, "monoisotopic_mass": 64270.0 }, "refseq": { "ac": "XP_024857459", "name": "protein CBFA2T1 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857459" }, "gene_names": [ { "name": "RUNX1T1", "type": "recommended", "evidence": [ { "id": "F1N0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ] }, { "name": "RUNX1T1", "type": "synonym", "evidence": [ { "id": "XP_024857459", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857459" } ] } ], "protein_names": [ { "name": "RUNX1 partner transcriptional co-repressor 1", "type": "synonym", "evidence": [ { "id": "F1N0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4/entry#names_and_taxonomy" } ] }, { "name": "protein CBFA2T1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024857459", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857459" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RUNX1T1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4", "locus": { "chromosome": "14", "start_pos": 72458757, "end_pos": 72301295, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017339", "url": "https://www.ensembl.org/id/ENSBTAG00000017339" } ] } } ], "crossref": [ { "id": "F1N0Y4", "url": "https://alphafold.ebi.ac.uk/entry/F1N0Y4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017339", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017339", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538628", "url": "https://www.ncbi.nlm.nih.gov/gene/538628", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538628", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538628", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HDMIATE", "url": "https://omabrowser.org/oma/group/HDMIATE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N242", "url": "https://www.orthodb.org/?gene=G3N242", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10379:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10379:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07531", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07531", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024857459", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857459", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBK5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBK5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDD5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDD5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T181", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T181", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T181-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T181-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Y4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N242", "url": "https://www.uniprot.org/uniprotkb/G3N242", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N242-1", "url": "https://www.uniprot.org/uniprotkb/G3N242-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPDRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 576, "header": "tr|F1N0Y4-1|F1N0Y4_BOVIN Isoform 1 of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=3 CANONICAL=F1N0Y4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBK5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK5/entry", "sequence": { "sequence": "MVGLSGPVQYRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 583, "header": "tr|A0A3Q1MBK5-1|F1N0Y4_BOVIN Computationally mapped isoform of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=1 CANONICAL=F1N0Y4-1" }, "locus": { "chromosome": "14", "start_pos": 72453446, "end_pos": 72301650, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083693.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083693.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067659.1" } ] } }, { "isoform_ac": "A0A3Q1MDD5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD5/entry", "sequence": { "sequence": "MISVKRNTWRALSLVIGDCRKKGNFEYCQDRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 603, "header": "tr|A0A3Q1MDD5-1|F1N0Y4_BOVIN Computationally mapped isoform of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=1 CANONICAL=F1N0Y4-1" }, "locus": { "chromosome": "14", "start_pos": 72453446, "end_pos": 72327700, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071803.1", "url": "https://www.ensembl.org/id/ENSBTAT00000071803.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072155.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072155.1" } ] } }, { "isoform_ac": "A0AAA9SHH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH3/entry", "sequence": { "sequence": "MVGLSGPVQYRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 560, "header": "tr|A0AAA9SHH3-1|F1N0Y4_BOVIN Computationally mapped isoform of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=1 CANONICAL=F1N0Y4-1" }, "locus": { "chromosome": "14", "start_pos": 72453446, "end_pos": 72301650, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097158.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097158.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081943.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081943.1" } ] } }, { "isoform_ac": "A0AAA9T181-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T181/entry", "sequence": { "sequence": "MLLAVCSLSLRAGQRLLSGVVSVYTGLNSHWKDRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 606, "header": "tr|A0AAA9T181-1|F1N0Y4_BOVIN Computationally mapped isoform of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=1 CANONICAL=F1N0Y4-1" }, "locus": { "chromosome": "14", "start_pos": 72453446, "end_pos": 72339743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090597.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090597.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090324.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090324.1" } ] } }, { "isoform_ac": "F1N0Y4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4/entry", "sequence": { "sequence": "MPDRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 576, "header": "tr|F1N0Y4-1|F1N0Y4_BOVIN Isoform 1 of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=3 CANONICAL=F1N0Y4-1" }, "locus": { "chromosome": "14", "start_pos": 72453446, "end_pos": 72341196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023058.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023058.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023058.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023058.6" } ] } }, { "isoform_ac": "G3N242-1", "url": "https://www.uniprot.org/uniprotkb/G3N242/entry", "sequence": { "sequence": "MSQSEVLNRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGSSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 581, "header": "tr|G3N242-1|G3N242_BOVIN Computationally mapped isoform of RUNX1 partner transcriptional co-repressor 1 OS=Bos taurus OX=9913 GN=RUNX1T1 PE=3 SV=3 CANONICAL=F1N0Y4-1" }, "locus": { "chromosome": "14", "start_pos": 72453446, "end_pos": 72359264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064358.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064358.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055947.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055947.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 266, "start_aa": "Thr", "end_pos": 266, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr266", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 567, "start_aa": "Thr", "end_pos": 567, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr567", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538628", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538628", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0G0-1", "protein_name": "RUNX1 partner transcriptional co-repressor 1", "gene_name": "Runx1t1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNTKRRCGGRAAGRLARSPPEGNLRGRAGGGGAGRGVGAAPQRSRADKSQGSEDVTCYRELLLAARGNLHLKITEGEGEDLPFVVLGEEEAAALASLLSPNTSAIQTGTRGDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSGSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGETPAVSSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 686 }, "evidence": [ { "id": "F1N0Y4", "url": "https://omabrowser.org/oma/group/F1N0Y4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A1D5P838-1", "protein_name": "RUNX1 translocation partner 1", "gene_name": "RUNX1T1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPDRTEKHSTMPDSPVDVKTQSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPNHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGNSSSSHSRQQSPVNPDPVTLESHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMAELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGETPAVSSSVTPSSGAGSPIDTPPAATPRSTTPGTPSTIEATPR", "length": 577 }, "evidence": [ { "id": "F1N0Y4", "url": "https://omabrowser.org/oma/group/F1N0Y4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1U9K3-1", "protein_name": "RUNX1 partner transcriptional co-repressor 1", "gene_name": "RUNX1T1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPDRTEKHSTMPDSPVDVKTPSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITSERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 577 }, "evidence": [ { "id": "F1N0Y4", "url": "https://omabrowser.org/oma/group/F1N0Y4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0AB32T784-1", "protein_name": "Protein CBFA2T1 isoform X1", "gene_name": "runx1t1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVGISTSFQSPPPPGTIWEMLLQSNERGFMRQKWLGDVCRLGMVYAGLTVSSDDRTEKRSTMPDSPADVKTQSRLTPPTMPPPPTTQGAPRTSSFTPTALTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELVHCARLAKQNPAQYLAQHEQLLLDTSTTSPVDSSELLMDVNENGKRRTPDRTKENGFEREPLHPEHPNKRPCTISPGQRFSPSNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPNHRELRDRPRPLGMHGSSTRQEEVIDHRLTDREWAEEWKHLDHVRKLLNCIMDMVEKTRRSLTVLRRCQETDREELNYWIRRYSDAEDLKKTSSTSTSQSRQQSPASQEGNALEVHRELLHRPVSGYVPEEIWKKAEEAVNEVKRQAMSELQKAVSEAERKAHEMISTERAKMERTVAEARRQAAEDALSVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHVCGQTLQAQQQGETPATVSSSATPSSGAGSPADTPSAAATPRSATPGTPSTVENTPR", "length": 635 }, "evidence": [ { "id": "F1N0Y4", "url": "https://omabrowser.org/oma/group/F1N0Y4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q06455-1", "protein_name": "Protein CBFA2T1", "gene_name": "RUNX1T1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MISVKRNTWRALSLVIGDCRKKGNFEYCQDRTEKHSTMPDSPVDVKTQSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 604 }, "evidence": [ { "id": "F1N0Y4", "url": "https://omabrowser.org/oma/group/F1N0Y4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61909-1", "protein_name": "Protein CBFA2T1", "gene_name": "Runx1t1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGDTPAVSSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR", "length": 577 }, "evidence": [ { "id": "F1N0Y4", "url": "https://omabrowser.org/oma/group/F1N0Y4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" }, { "name": "nuclear matrix", "id": "GO:0016363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y4", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" }, { "id": "PS50865", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MYND-type", "eco_id": "ECO_0000259", "start_pos": 487, "end_pos": 523, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y4" }, { "id": "PS51119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TAFH", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 188, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 266, 567 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8P8-1", "uniprot_ac": "E1B8P8", "uniprot_id": "E1B8P8_BOVIN", "mass": { "chemical_mass": 91577.0, "monoisotopic_mass": 91577.0 }, "refseq": { "ac": "XP_010813414", "name": "NTPase KAP family P-loop domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010813414" }, "gene_names": [ { "name": "NKPD1", "type": "recommended", "evidence": [ { "id": "E1B8P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P8" } ] }, { "name": "NKPD1", "type": "synonym", "evidence": [ { "id": "XP_010813414", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010813414" } ] } ], "protein_names": [ { "name": "NTPase KAP family P-loop domain containing 1", "type": "synonym", "evidence": [ { "id": "E1B8P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P8/entry#names_and_taxonomy" } ] }, { "name": "NTPase KAP family P-loop domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010813414", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010813414" } ] } ], "function": [ { "annotation": "May play a role in vesicular transport during the biogenesis of melanosomes.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MDQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDQ9#function" }, { "database": "UniProtKB", "id": "ARBA00055456", "url": "https://www.uniprot.org/uniprotkb/ARBA00055456#function" }, { "database": "UniProtKB", "id": "A0AAA9S9U2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U2#function" }, { "database": "UniProtKB", "id": "A0AAF6YQJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQJ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8P8", "url": "https://www.uniprot.org/uniprotkb/E1B8P8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NKPD1", "url": "https://www.uniprot.org/uniprotkb/E1B8P8", "locus": { "chromosome": "18", "start_pos": 52806783, "end_pos": 52826341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020074", "url": "https://www.ensembl.org/id/ENSBTAG00000020074" } ] } } ], "crossref": [ { "id": "E1B8P8", "url": "https://alphafold.ebi.ac.uk/entry/E1B8P8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14944", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14944", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512261", "url": "https://www.ncbi.nlm.nih.gov/gene/512261", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "789234", "url": "https://www.ncbi.nlm.nih.gov/gene/789234", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011646", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011646", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789234", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789234", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RQREWHC", "url": "https://omabrowser.org/oma/group/RQREWHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8P8", "url": "https://www.orthodb.org/?gene=E1B8P8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12817:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12817:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22674", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22674", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22674:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22674:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07693", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07693", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010813414", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010813414", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9U2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4L9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YQJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY80", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY80-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8P8", "url": "https://www.uniprot.org/uniprotkb/E1B8P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8P8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8P8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHQHYTVHFAKGALPPRIATERYFLDPELGHRKGRCHQRCHDPAAPGAHRSCQPTPQACRQPAYHDHQGGRGGCRRGPQPPTQQQQQQRRQPQPPPPQPLQQRLCSVHGVQKGPPATTTAPAQPATAPQPPPNSLTATSTLATGGPALPYAAGTLLEPSRPTDARPLPAPAACGCFTSYSSDILTEDDVYCSCLAKTLCHVPVPVTVGFYAPFGCRLHMMLDKITALMQQEAAQREAEELEHVQWRPRPVQGWAFPKLLWYLVFLRPIITEVHLRRKNVKFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRHQYGALPFSVYSVLGTKAATTQGFRQREWQCRHRVCLALLALLAVLSLGVGLLYLSVGARSLSHRATNSSLLRVFGGAATTLSGSGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGSMKGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVQSRDDLLYREMTRKLRPLGGAGARGGEGAQLLEVQTQAGGEREQSRIDAEAARRIREALFCLHDERDCLYEYVPDNVVSMRRIVNTVPITVRLLQQQQGDFGGPSPRQAVAWVVLANQWPCRLSWALQCLEDRQQAGGAPEARARLWDVFSDHSRELHTMTKPLQNVLDLDGDPELFERFLGADFPFTVAEAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPARDSPHAANGANHAPGPARAGHPAGHSPVHASEAHHPRDWAQGGKPRPMA", "length": 828, "header": "tr|E1B8P8-1|E1B8P8_BOVIN Isoform 1 of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=3 CANONICAL=E1B8P8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDQ9/entry", "sequence": { "sequence": "MADPALFEFLHTEMVAELWAQDPDPGPGGQKTSLLVLEGMGFRVGQALGERLPRETLTFREELDILKFLCKDLWVAVFHKQMDSLRTNHQGTYVLQDNSFPLLVRMASGLQYLEEAPKFLAFTCGLLRGTLSTLGVKSLVTASVAALPASSGGITRLDSAGLCHSLPEVGPRPSCTSTTPSTLPRVPCPPGLPPSATSWTQSWGTEKDAVIRGAMTQRHLVPTGLVSQPHRHAGSRPTTTTRGGAVAVAGVPSPPPSSSSSRGGSPSPHLPSPCSSVSALFTGSRRGHLQPPLPPRSRPPPPSHPPTHSPRPAPWPPAAQPCPTQPAPSWSPAGPRTPGPCPPPQPAAASPPTAPTS", "length": 357, "header": "tr|A0A3Q1MDQ9-1|E1B8P8_BOVIN Computationally mapped isoform of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=1 CANONICAL=E1B8P8-1" }, "locus": { "chromosome": "18", "start_pos": 52826123, "end_pos": 52810366, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085476.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085476.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066984.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066984.2" } ] } }, { "isoform_ac": "A0AAA9S9U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U2/entry", "sequence": { "sequence": "MADPALFEFLHTEMVAELWAQDPDPGPGGQKTSLLVLEGMGFRVGQALGERLPRETLTFREELDILKFLCKDLWVAVFHKQMDSLRTNHQGTYVLQDNSFPLLVRMASGLQYLEEAPKFLAFTCGLLRGTLSTLGVKSLVTASVAALPAWPRITEDWGPSWHDLSHTCH", "length": 169, "header": "tr|A0AAA9S9U2-1|E1B8P8_BOVIN Computationally mapped isoform of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=1 CANONICAL=E1B8P8-1" }, "locus": { "chromosome": "18", "start_pos": 52826123, "end_pos": 52817278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128792.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128792.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078913.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078913.1" } ] } }, { "isoform_ac": "A0AAA9T4L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4L9/entry", "sequence": { "sequence": "MADPALFEFLHTEMVAELWAQDPDPGPGAAPGDANLQGRAGHPQVPVQRPVGGCVPQADGQPPYQPPGDLRPAGQQLPPPCSDGLGSAVPGGSAQVPGLHLRPPAWHPQHPGRQEPGHRLRGSPARL", "length": 127, "header": "tr|A0AAA9T4L9-1|E1B8P8_BOVIN Computationally mapped isoform of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=1 CANONICAL=E1B8P8-1" }, "locus": { "chromosome": "18", "start_pos": 52826123, "end_pos": 52817013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108923.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108923.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091456.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091456.1" } ] } }, { "isoform_ac": "A0AAF6YQJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQJ0/entry", "sequence": { "sequence": "MADPALFEFLHTEMVAELWAQDPDPGPGGQKTSLLVLEGMGFRVGQALGERLPRETLTFREELDILKFLCKDLWVAVFHKQMDSLRTNHQVQAPLRLPGTLLCPQGTYVLQDNSFPLLVRMASGLQYLEEAPKFLAFTCGLLRGTLSTLGVKSLVTASVAALPACKFQVVIQKL", "length": 174, "header": "tr|A0AAF6YQJ0-1|E1B8P8_BOVIN Computationally mapped isoform of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=1 CANONICAL=E1B8P8-1" }, "locus": { "chromosome": "18", "start_pos": 52826123, "end_pos": 52816985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009288.4", "url": "https://www.ensembl.org/id/ENSBTAT00000009288.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009288.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009288.3" } ] } }, { "isoform_ac": "A0ABI0NY80-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY80/entry", "sequence": { "sequence": "MHQHYTVHFAKGALPPRIATERYFLDPELGHRKDILTEDDVYCSCLAKTLCHVPVPVTVGFYAPFGCRLHMMLDKITALMQQEAAQREAEELEHVQWRPRPVQGWAFPKLLWYLVFLRPIITEVHLRRKNVKFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRHQYGALPFSVYSVLGTKAATTQGFRQREWQCRHRVCLALLALLAVLSLGVGLLYLSVGARSLSHRATNSSLLRVFGGAATTLSGSGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGSMKGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVQSRDDLLYREMTRKLRPLGGAGARGGEGAQLLEVQTQAGGEREQSRIDAEAARRIREALFCLHDERDCLYEYVPDNVVSMRRIVNTVPITVRLLQQQQGDFGGPSPRQAVAWVVLANQWPCRLSWALQCLEDRQQAGGAPEARARLWDVFSDHSRELHTMTKPLQNVLDLDGDPELFERFLGADFPFTVAEAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPARDSPHAANGANHAPGPARAGHPAGHSPVHASEAHHPRDWAQGGKPRPMA", "length": 680, "header": "tr|A0ABI0NY80-1|A0ABI0NY80_BOVIN Computationally mapped isoform of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=1 CANONICAL=E1B8P8-1" }, "locus": { "chromosome": "18", "start_pos": 52813596, "end_pos": 52807080, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151489.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151489.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105157.1" } ] } }, { "isoform_ac": "E1B8P8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8P8/entry", "sequence": { "sequence": "MHQHYTVHFAKGALPPRIATERYFLDPELGHRKGRCHQRCHDPAAPGAHRSCQPTPQACRQPAYHDHQGGRGGCRRGPQPPTQQQQQQRRQPQPPPPQPLQQRLCSVHGVQKGPPATTTAPAQPATAPQPPPNSLTATSTLATGGPALPYAAGTLLEPSRPTDARPLPAPAACGCFTSYSSDILTEDDVYCSCLAKTLCHVPVPVTVGFYAPFGCRLHMMLDKITALMQQEAAQREAEELEHVQWRPRPVQGWAFPKLLWYLVFLRPIITEVHLRRKNVKFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRHQYGALPFSVYSVLGTKAATTQGFRQREWQCRHRVCLALLALLAVLSLGVGLLYLSVGARSLSHRATNSSLLRVFGGAATTLSGSGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGSMKGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVQSRDDLLYREMTRKLRPLGGAGARGGEGAQLLEVQTQAGGEREQSRIDAEAARRIREALFCLHDERDCLYEYVPDNVVSMRRIVNTVPITVRLLQQQQGDFGGPSPRQAVAWVVLANQWPCRLSWALQCLEDRQQAGGAPEARARLWDVFSDHSRELHTMTKPLQNVLDLDGDPELFERFLGADFPFTVAEAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPARDSPHAANGANHAPGPARAGHPAGHSPVHASEAHHPRDWAQGGKPRPMA", "length": 828, "header": "tr|E1B8P8-1|E1B8P8_BOVIN Isoform 1 of NTPase KAP family P-loop domain containing 1 OS=Bos taurus OX=9913 GN=NKPD1 PE=4 SV=3 CANONICAL=E1B8P8-1" }, "locus": { "chromosome": "18", "start_pos": 52813596, "end_pos": 52807080, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053125.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053125.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052685.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052685.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 206, "start_aa": "Thr", "end_pos": 206, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr206", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:789234", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789234", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZR21-1", "protein_name": "NTPase, KAP family P-loop domain containing 1", "gene_name": "Nkpd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQKNYNVHFTKNARAPNEQHFLDPELGHQKGCCRQCYQDLVATHTHGPYQLSPQAHWQQTYRSHRGGSGCRRCPQPLILQRQRQQQKRQPPSFPPSPQRQRLCPVRGAQKGSPAIAAARMGPASAPQPATSSPTAVPPTASSGPALPSAAGALLEPSEPTEARPLPAPAACGSFTSYGADILTEDDVYCSCLAKTLCHVPVPVTVGFYAPFGCRLHLMLDKIMTLMQQEAAQRESEELQRVQWQPRPVRGWGVPQLLWFLVFLQPVITELHLRRRNVRFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRHHYGALPFSVYSVLGNKPCGPRDGLCQREWHCRRRVCLALLALLAALCLGVGLLYLSLGGHAPGHAERGVLKALGGAATTLSGSGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGNMKGTADNGYLFLNRTVTLPFSVPVMGRRTKLQFLHDAVRSRDDLLFRELTIKLQPQSPGVLGAGEGTQLLAVETQADTERTQGRVDAEAARRIQEALCCLHDEGDCLYEYVPDNVVSMRRIVNTVPITVRLLQQQQHQQPDRVGPTPRHAVAWVVLANQWPCRLSWVLQCLEDRQQAGGAPEGRARLWDVFCDNSRELHTMTKALQNVLDLDGDPELFERFLGTDFPFTVADAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPSRDGPQAGPRATIAAGTSQAGQGSGHSREAHQTRDRTHGVKPRPMA", "length": 824 }, "evidence": [ { "id": "E1B8P8", "url": "https://omabrowser.org/oma/group/E1B8P8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0VF94-1", "protein_name": "NTPase KAP family P-loop domain-containing protein 1", "gene_name": "Nkpd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQQEAAQRESEELQRVQWQPRRVRGWGVPKLLWFLVFLQPVITELHLRRRNVRFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRHHYGALPFSVYSVLGNKPCGPRDGLCQREWHCRRRVCLALLALLAALCLGVGLLYLSLGGHAPGHGERGVLKALGGAATTLSGSGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGNMKGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVRSRDDLLFRELTIKLQPQSPGNLGAGEGTQLLAVETQGDAERTQGRVDAEAARRIQEALCCLHDEGDCLYEYVPDNVVSMRRIVNTVPITVRLLQQQQQQQPDRVGPTPRHAVAWVVLANQWPCRLSWVLQCLEDRQQAGGAPEGRSRLWDVFCDNSRELHTMTKALQNVLDLDGDPELFERFLGTDFPFTVAEAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPSQDGPQASPRAIIAAGTSHAGQGSGHSKEAHQTRDRTHGGKPRPMA", "length": 599 }, "evidence": [ { "id": "E1B8P8", "url": "https://omabrowser.org/oma/group/E1B8P8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q17RQ9-1", "protein_name": "NTPase KAP family P-loop domain-containing protein 1", "gene_name": "NKPD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQQEAAQRESEELQHVQWRPRAVSGWGVPQLLWYLVFLQPIITEVHLRRRNVQFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRRHYGALPFSVYSVLGNKPATRQDCCQSEWHCRRRVCLGLLALLAALGLGVGLLYLSLGGHALGHGSPSGSLLKVFGGAATTLSGSGLLMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRRRLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGNMKGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVQSRDDLLYREMTRKPWLPGDAGGESAQLLAVQAQAGTERGQGRIDDEAARRIQEALFCLHDERDCLYEYVPDNVVSMRRIVNTVPITVRLLQQQQQQGDFGGPTPRQAVAWVVLANQWPCRLSWALQCLEDRQQTGGAPEGRARLWDVFRDNSRELHTMTKALQNVLDLDGDPELFERFLGADFPFTVAEAQSLLRCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPTRDTPHAAHRANSASRAPPSGRASGQAGEGHHTGDLAHRGKLWPVACALFRPGQSSPGGP", "length": 610 }, "evidence": [ { "id": "E1B8P8", "url": "https://omabrowser.org/oma/group/E1B8P8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B8P8", "url": "https://www.uniprot.org/uniprotkb/E1B8P8" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1B8P8", "url": "https://www.uniprot.org/uniprotkb/E1B8P8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Golgi vesicle transport", "id": "GO:0048193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193", "evidence": [ { "database": "UniProtKB", "id": "E1B8P8", "url": "https://www.uniprot.org/uniprotkb/E1B8P8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8P8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 828, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8P8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8P8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P8" }, { "id": "PF07693", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07693" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KAP NTPase", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 643, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 206 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 378, "end_pos": 380 }, { "start_pos": 525, "end_pos": 527 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBW2-1", "uniprot_ac": "E1BBW2", "uniprot_id": "E1BBW2_BOVIN", "mass": { "chemical_mass": 108191.0, "monoisotopic_mass": 108191.0 }, "refseq": { "ac": "XP_002684801", "name": "coiled-coil domain-containing protein 191 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684801" }, "gene_names": [ { "name": "CCDC191", "type": "recommended", "evidence": [ { "id": "E1BBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW2" } ] }, { "name": "CCDC191", "type": "synonym", "evidence": [ { "id": "XP_002684801", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684801" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 191", "type": "synonym", "evidence": [ { "id": "E1BBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW2/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 191 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002684801", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684801" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBW2", "url": "https://www.uniprot.org/uniprotkb/E1BBW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC191", "url": "https://www.uniprot.org/uniprotkb/E1BBW2", "locus": { "chromosome": "1", "start_pos": 58636236, "end_pos": 58735219, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004975", "url": "https://www.ensembl.org/id/ENSBTAG00000004975" } ] } } ], "crossref": [ { "id": "E1BBW2", "url": "https://alphafold.ebi.ac.uk/entry/E1BBW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004975", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004975", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532832", "url": "https://www.ncbi.nlm.nih.gov/gene/532832", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR052270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532832", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532832", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NRWKQFT", "url": "https://omabrowser.org/oma/group/NRWKQFT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGB2", "url": "https://www.orthodb.org/?gene=A0A3Q1MGB2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N1F4", "url": "https://www.orthodb.org/?gene=A0A3Q1N1F4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBW2", "url": "https://www.orthodb.org/?gene=E1BBW2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22028:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22028:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002684801", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684801", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGB2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGB2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1F4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW2", "url": "https://www.uniprot.org/uniprotkb/E1BBW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLAPQDRSSSRKRTGLNRWKQITRKPSPTKPVFDPDNVEHWIKRVEKASEFAVSQVFSAGNSNLSRRLWGQLVDLETLEQIEDHEEVYAEAQELVNDWLDTKLKPELASDGDNDAEDTVSSIRPVPEASGHLKYDRFDDLCGYLEEEDESTTVQKFIDHLLHKDVVDSGILEDLGMNENQDKKWQKDPRLTMEMRHKQVKENRLRREKELERQRIEKTLKKSAFLEAQYLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVEEAWKIEKKKQENAPKIPEKGTFQSVHILLDEEKMAKERKKKLKELLIQTFKENHQCQKRYFSAWHKLILDHRIKLGKAGTLSDWKLQLKVLRAWRDYTRSQKLGRETQAIENYLREENRKQQLATEHNRKQVLQHHFTEWQHWHRAEILKRELAVTKEETRKKMNELLEAASLGKLSANMSSSIGLLEEATAMEDPPRNGEVAAVPALWEKPPSGSSGCLPSCHLRRPTKSILQVPLQKAPLDTSDSKPHKGPGDEPSQQPGNKKKFRTSSWKAEPVCMGHFCNRHIFQQQLIEKQKKKLQEQQKTILELKENQRLAEVRRAAGHTHPQSCQLSNPGEDEWERTCQVLPNSPVASPGTEGSRSDSRNSLSGPRRNPRQMMAPHPILKAMEERAVQRAERRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLEKKREEKRLKKMKELEKQKRIKRNQQLEAIAKEHYERVLLRKKGLEPWKRLKMQSMQNLQVAKEHHSLTLQRKCLLTWFQWSQESLAKKMAQADQFYSQILLRRVIRSWLQHLIDLDEEVRKLCIHFLQKKIFRAWRDMVREARVDSQNKHQIAVEHSDRRILWIMFQTWKKFAKFTKEEREKEERREQLRRKVAEILPDFQMFTLL", "length": 913, "header": "tr|E1BBW2-1|E1BBW2_BOVIN Isoform 1 of Coiled-coil domain containing 191 OS=Bos taurus OX=9913 GN=CCDC191 PE=4 SV=2 CANONICAL=E1BBW2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGB2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGB2/entry", "sequence": { "sequence": "MLLAPQDRSSSRKRTGLNRWKQITRKPSPTKPVFDPDNVEHWIKRVEKASEFAVSQVFSAGNSNLSRRLWGQLVDLETLEQIEDHEEVYAEAQELVNDWLDTKLKPELASDGDNDAEDTVSSIRPVPEASGHLKYDRFDDLCGYLEEEDESTTVQKFIDHLLHKDVVDSGILEDLGMNENQDKKWQKDPRLTMEMRHKQVKENRLRREKELERQRIEKTLKKSAFLEAQYLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVEEAWKIEKKKQENAPKIPEKGTFQSVHILLDEEKMAKERKKKLKELLIQTFKENHQCQKRYFSAWHKLILDHRIKLGKAGTLSDWKLQLKVLRAWRDYTRSQKLGRETQAIENYLREENRKQQLATEHNRKQVLQHHFTEWQHWHRAEILKRELAVTKEETRKKMNELLEAASLGKLSANMSSSIGLLEEATAMEDPPRNGEVAAVPALWEKPPSGSSGCLPSCHLRRPTKSILQVPLQKAPLDTSDSKPHKGPGDEPSQQPGNKKKFRTSSWKAEPVCMGHFCNRHIFQQQLIEKQKKKLQEQQKTILELKENQRLAEVRRAAGHTHPQSCQLSNPGEDEWERTCQVLPNSPVASPGTEGSRSDSRNSLSGPRRNPRQMMAPHPILKAMEERAVQRAERRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLEKKREEKRLKKMVAKEHHSLTLQRKCLLTWFQWSQESLAKKMAQADQFYSQILLRRVIRSWLQHLIDLDEEVRKLCIHFLQKKIFRAWRDMVREARVDSQNKHQIAVEHSDRRILWIMFQTWKKFAKFTKEEREKEERREQLRRKVAEILPDFQMFTLL", "length": 865, "header": "tr|A0A3Q1MGB2-1|E1BBW2_BOVIN Computationally mapped isoform of Coiled-coil domain containing 191 OS=Bos taurus OX=9913 GN=CCDC191 PE=4 SV=1 CANONICAL=E1BBW2-1" }, "locus": { "chromosome": "1", "start_pos": 58735020, "end_pos": 58637240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080195.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080195.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070212.1" } ] } }, { "isoform_ac": "A0A3Q1N1F4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1F4/entry", "sequence": { "sequence": "MLLAPQDRSSSRKRTGLNRWKQITRKPSPTKPVFDPDNVEHWIKRVEKASEFAVSQVFSAGNSNLSRRLWGQLVDLETLEQIEDHEEVYAEAQELVNDWLDTKLKPELASDGDNDAEDTVSSIRPVPEASGHLKYDRFDDLCGYLEEEDESTTVQKFIDHLLHKDVVDSGILEDLGMNENQDKKWQKDPRLTMEMRHKQVKENRLRREKELERQRIEKTLKKSAFLEAQYLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVEEAWKIEKKKQENAPKIPEKGTFQSVHILLDEEKMAKERKKKLKELLIQTFKENHQCQKRYFSAWHKLILDHRIKLGKAGTLSDWKLQLKVLRAWRDYTRSQKLGRETQAIENYLREENRKQQLATEHNRKQVLQHHFTEWQHWHRAEILKRELAVTKEETRKKMNELLEAASLGKLSANMSSSIGLLEEATAMEDPPRNGEVAAVPALWEKPPSGSSGCLPSCHLRRPTKSILQVPLQKAPLDTSDSKPHKGPGDEPSQQPGNKKKFRTSSWKAEPVCMGHFCNRHIFQQQLIEKQKKKLQEQQKTILELKENQRLAEVRRAAGHTHPQSCQLSNPGEDEWERTCQVLPNSPVASPGTEGSRSDSRNSLSGPRRNPRQMMAPHPILKAMEERAVQRAERRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLEKKREEKRLKKMKELEKQKRIKRNQQLEAIAKEHYERVLLRKKGLEPWKRLKMQSMQNLQVAKEHHSLTLQRKCLLTWFQWSQESLAKKMAQADQFYSQILLRRVIRSWLQHLIDLDEEVRKLCIHFLQKKIFRAWRDMVREARVDSQNKHQIAVEHSDSCQKQTERLTEAAA", "length": 879, "header": "tr|A0A3Q1N1F4-1|E1BBW2_BOVIN Computationally mapped isoform of Coiled-coil domain containing 191 OS=Bos taurus OX=9913 GN=CCDC191 PE=4 SV=1 CANONICAL=E1BBW2-1" }, "locus": { "chromosome": "1", "start_pos": 58735020, "end_pos": 58648217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071943.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071943.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062874.1" } ] } }, { "isoform_ac": "E1BBW2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW2/entry", "sequence": { "sequence": "MLLAPQDRSSSRKRTGLNRWKQITRKPSPTKPVFDPDNVEHWIKRVEKASEFAVSQVFSAGNSNLSRRLWGQLVDLETLEQIEDHEEVYAEAQELVNDWLDTKLKPELASDGDNDAEDTVSSIRPVPEASGHLKYDRFDDLCGYLEEEDESTTVQKFIDHLLHKDVVDSGILEDLGMNENQDKKWQKDPRLTMEMRHKQVKENRLRREKELERQRIEKTLKKSAFLEAQYLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVEEAWKIEKKKQENAPKIPEKGTFQSVHILLDEEKMAKERKKKLKELLIQTFKENHQCQKRYFSAWHKLILDHRIKLGKAGTLSDWKLQLKVLRAWRDYTRSQKLGRETQAIENYLREENRKQQLATEHNRKQVLQHHFTEWQHWHRAEILKRELAVTKEETRKKMNELLEAASLGKLSANMSSSIGLLEEATAMEDPPRNGEVAAVPALWEKPPSGSSGCLPSCHLRRPTKSILQVPLQKAPLDTSDSKPHKGPGDEPSQQPGNKKKFRTSSWKAEPVCMGHFCNRHIFQQQLIEKQKKKLQEQQKTILELKENQRLAEVRRAAGHTHPQSCQLSNPGEDEWERTCQVLPNSPVASPGTEGSRSDSRNSLSGPRRNPRQMMAPHPILKAMEERAVQRAERRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLEKKREEKRLKKMKELEKQKRIKRNQQLEAIAKEHYERVLLRKKGLEPWKRLKMQSMQNLQVAKEHHSLTLQRKCLLTWFQWSQESLAKKMAQADQFYSQILLRRVIRSWLQHLIDLDEEVRKLCIHFLQKKIFRAWRDMVREARVDSQNKHQIAVEHSDRRILWIMFQTWKKFAKFTKEEREKEERREQLRRKVAEILPDFQMFTLL", "length": 913, "header": "tr|E1BBW2-1|E1BBW2_BOVIN Isoform 1 of Coiled-coil domain containing 191 OS=Bos taurus OX=9913 GN=CCDC191 PE=4 SV=2 CANONICAL=E1BBW2-1" }, "locus": { "chromosome": "1", "start_pos": 58735020, "end_pos": 58637240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006550.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006550.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006550.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006550.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532832", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532832", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JUG8-1", "protein_name": "Coiled-coil domain containing 191", "gene_name": "Ccdc191", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPGRSSSGMSDPCLAIKWRNYNSQHHLKAVWEETRLSLLWPKSRPAPAKMLLAPQGGFASKKRMELSRWKRLSRKLNLKSSFEPDNVGHWIKRVEKASEFAISNTYSTRNADLPGRFWRQAVDLATCEQTEYHDDVYEEAQELVNEWLDNKLKQELASDGEGESTVLSSPPVPDAHGHLKYDRFDDLCGYLEEEEESATVQKFIEHLLHKEVVASEVVEELGMKENQGKRQQKDPRLTMEMRHKQVKENRLRREKQLESQRVESALKKAAFLEAQCLVQEEKKRKALLAKKEKEEIQREMVKLRREILERRHTVEEAWKTEKKRQEESSQRNAERKMMKSAHIHLGEEKVAKERKRELREILIRTFKENQQCQKRYFSAWHKLILDHRIKLGKAGTLSDWKLQLKVLRAWRDHTRSQKLERETKALENDLREENRKQQLATEFNRKQVLRYCFGGWQRWHGSEVIKRELALAKEQTRKKMDELLKAASLGKLNSKGSSGIGLLAEAPAVVDPAVGSGEVTIMSPLWEKPPVENSGCTLSHSPERTTKGNFQGTLPDVSQNTPGTKQAKTAAGETSEQPGSREDPGTTTQEADAVCVGHFRCHHVYQQQLIEKQKKKLEEQQKTIQKLKANQWLAEARQASERTTAATGGHSCSQSNLRGAGDLQGTCQRLLNSSVPSLRCKDSRADSRKPLSPSKRTLKQPTAPHPLLKAMEERAIQRAERRQILAERKKKQEEDKLAQLKSQEEERQKKDAEEKEAQLERKREEKRLKKMKELEKQKRIQRSQELEAVAKGHYEKTLLRKRGLEPWKRLRVQSKQNTEVAEEHHSLTSQRKCLLSWLQYSQERLATMTAKADQFYSQLLCRRVIRGWLQYVSDVEEEVRKLCVYLLQKKTFKAWLSTVKELEMESQKKLKVAAEHCDRKILRVTLEMWKAFVKLTKEDRVREERRDQLRRKVAEILPDFQMLVPS", "length": 967 }, "evidence": [ { "id": "E1BBW2", "url": "https://omabrowser.org/oma/group/E1BBW2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XVT0-1", "protein_name": "Coiled-coil domain containing 191", "gene_name": "CCDC191", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPRGTVGRRAAMALPGRRSRLFRWRRLSAPTGPQATFGSDSTEYWMKRVEQASEYAVSEAFSLQKLRYPQGLCDPAARLETVEQLQEHDEACMEARELLSNWAKSKLQLQLTSDGEAEVGSVLENPTAPLKYTRFDDLYSYLEHELESSSVQEYLQHLLQSEAVNCGIVENLRLEDIKGKQKPADPRITMEIRHKQVKENRLRHQKALELQRQEKALRKAILCEAKLQIQEEDRRKALEAKKEEEEIRREMVKLRKEMAEKRQTMAEAWRMEQKRQEKSQKLSMQEVSINVSPPMDPKKEEQEKEKQRRAQELLSRIHTNKQRCMQRHFSAWFRLILEHRIKMEKARALADWKCQQKVLRAWRNYTWAQKVEQETQQLEFHLQDQNRKNQLSAEHNQRRLLRCCFLAWQHWSQAEADKRELQLKREETKRKMAKLLAAVSGEMGKSGLNRTLEVSKSETAKVNQHQVLQQDELTKTCLIQEEPDQSRDHSCGDAAHTSPSYRKPKFAWQITLKHAALSAQDQVMYRNEIAGLPKQFQAPSPKTAPPYSSCFEHHHTFQQHLIEEQKQQLQKQQELILELQENQRLSRAKEEAVQATAASQAPDSASETREKKLKSRKQSRYQNTTPLSLPVSPEPKNTKAATQGKRPSSQPTHPIVKAMEERAIQRTERRRKLEEAKQRREEEKLAQLKAEEEARQRKEAEEREAQQEKRREEKRQQKLKELEKQRRLEKEQQLQKKARDHYEKALLRKLGMVPWKKLREQAKENLMVAQTHHCLSLQRKCLMSWFQHTQERLMKKVSWAEDFFSHTLIRWCFRRWLKYRDYLSTLEEKANTLHAVCLKRKCFWAWFDLTMEEKSTLREKLKIATDHCNKRLMLDAFKAWRQYPLLMKKEREREERRNQLRRRVAEILPDFQT", "length": 915 }, "evidence": [ { "id": "E1BBW2", "url": "https://omabrowser.org/oma/group/E1BBW2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SP97-1", "protein_name": "Coiled-coil domain containing 191", "gene_name": "CCDC191", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLTPQERSSSKKGTGLNRWKQFTRKPSPTKPMFDPDNMEHWIKRVEKASEFAVSNLSRRPWGQIIDLETPEQIEDRDEVYAEAQELVNDWLDTKLKQELASDGEGDAEDTELSSPPFPEVNGHLKYDKFDDLCGYLEEEEESTTVQKFIDHLLHKDVVDSRMLEDLGMNENQDKKQQKDPHLTMEMRHKQVKENRLRREKELERQKIEKTLKKSAFLEAHFLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVEEAWKIEKKKQDENSPKNPEKGVFQSVHILDAENIAKERKKKLKKLLIQTFKEDCECQKRYFSAWHKLILDHRIKLGKAGTLSDWKVQLKVLRAWRDYTRSQKLGRETQAMENDLREENRKQQLAAEYNRKQVLRHHFTEWQHWHRAEILKRELAITKEETRKKMNELLKAALLGKLSATVSSSSNLLEATAMEDPSRNEEVPLQNVPLDTSDDKPHKTLDLGPFQQPGNKKLRTSSQKAEPIRMGYFHNRHIFQQQLIEKQKKKLQEQQKTILELKKNQQLAEVPQAVGHGDARSCLLSNPREDEQERTCQRLSNSPVESPGTEHGRSESRNSLSGPRRNPRQLMAPHPILKAMEERAVQRAERRRILAERKKKQEEEKLAQLKAQEEERQKREAEEKEAKLEKKREKKRLKKMKELEKQERIKRNQQLDTIAKEHYKKVLLRKKGLEPWKRLRMQSKQNIQVAIEHHSLTLQRKCLLTWFQWSQESLARKIAQADQFYYQILLRRVTRSWLQYLIDLEEEVRKLCVHFLQKKVFRAWYNLVREAKIDSQNKHKIAVEHSDRRILQITFQTWRKFAKFTKEERGKEERREQLRRKVAEILPDFRMFTPL", "length": 870 }, "evidence": [ { "id": "E1BBW2", "url": "https://omabrowser.org/oma/group/E1BBW2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "J3QQ27-1", "protein_name": "Coiled-coil domain containing 191", "gene_name": "Ccdc191", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELSRWKRLSRKLNLKRVEKASEFAISNTCSTRNADLPGRFWRQAVDLATCEETEYHDDVYEEAQELVNDWLDNKLKQELASDGEGESTVLSSPPVPDAHDHLKYDKFDDLCGYLEEEEESATVQKFIEHLLHKEVVASEMVEELGMEENQDKRQQKDPRLTMEMRHKQVKENRLRREKQLESQRMADALKKAAFLEAQSLVQEEKRRKALLAKKEKEDIQREMVKLRREILERRHTVEEAWKTEKKRQEEISQKNSEGKMMESTHIHLDEEKVAKERKRKLRETLIQTFKENQQCQKRYFSAWHKLILDHRIKLGKAGTLSDWKLQLKVLRAWRDHTRSRKLERETKALENDLREENRKQQLATEFNRKHVLRYCFGEWQRWHGSEVIKRELALAKEQTRKKMDELLKAASLGKLSSKGSSGIGLVAEAVAVMDPAVGSGEVTILSPLWERPPVESSGCTLSHSPERTTKGNCQGPLPDVSGSTPGTEQCKAVAAETSEQPGSCERPGTTRQEAEAACVRHFHRSHVYQQQLIEKQKKKLEQQQKTIQKLKENQRLAEARWAAKRAPAVTEGQNCLQSDPRGARDPQGTCQRLLKCEDSRTDCRKPLSASRRTLKQPTAPHPLLKAMEERAIQRAERRQILAEKKKKQEEDKLAQLKAQEEERQKKDAEEKEAQLERKREERRLKKMKELEKQKRIKRIQELEAVAKGHYERVLLRKKGLEPWKRLRMQSKHNIEVAEKYHSLALQRKCLLNWFQYSQETLAMKTAKADQFYSQLLYRRSIRSWLQYVSDLEKEVRRLCTYLLQKKIFKAWLTTVRELKMDSQRKLKVATEHCDRKILMLTLEMWKAFVKLTKEERVKEERRDHLRRKVSEILPDFQMLVPP", "length": 883 }, "evidence": [ { "id": "E1BBW2", "url": "https://omabrowser.org/oma/group/E1BBW2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NCU4-1", "protein_name": "Coiled-coil domain-containing protein 191", "gene_name": "CCDC191", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLAPQGRSFSKKRMGLNRWKRFTRKPSPKPTFGPDSVEHWIKRVEKASEFAVSNAFFTRNSDLPRSPWGQITDLKTSEQIEDHDEIYAEAQELVNDWLDTKLKQELASEEEGDAKNTVSSVTIMPEANGHLKYDKFDDLCGYLEEEEESTTVQKFIDHLLHKNVVDSAMMEDLGRKENQDKKQQKDPRLTMEMRHKQVKENRLRREKELEYQRIEKTLKKSAFLEAQCLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVKAAWKIEKKRQEENSQNSSEKVMFQSTHILPDEEKMVKERKRKLKEVLIQTFKENQQCQKRYFAAWHKLILDHRIKLGKAGTLSDWKIQLKVLRAWRDYTRFQKLERETQALENDLREENRKQQLATEYNRKQVLRHCFTEWQHWHGAELLKRELALTKEETRKKMDALLQAASLGKLSANGLSGISLPEEATAMVGPPVKNGQETAVPPLWEKPPLGSSGCMLSPPLGRTTTGNLQGSLQNVSLSAPGNKQHKTLGAEPSQQPGSNETLRTTSQKAEPLCLGHFHNRHVFQQQLIEKQKKKLQEQQKTILELKKNLQLAEAQWAAEHALAVTEAQSHLLSKPREEEPRTCQMLVNSPVASPGTEGRSDSRNSLSGLRRKPKQLMTPHPILKAMEERAIQRAECRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLERKREEKRLKKMKELEKQKRIKRNQQLEAIAKEHYERVLLRKKGLEPWKRLRMQSKQNIQVAEEHYSLFLQRKYMLTWFQRSQESLARKMAQADQFYSQILLKRVIQSWLQYVIDLQEEVRKFCVHFLQKKIFRAWFNMVREVKIDSQGKHEIAAEHSDRRILWITLRTWKKFVKFMKEERVKEERRQQLRRKVVEILPDFQVPGRYHELYQQSDTWSLSKTSLVNE", "length": 936 }, "evidence": [ { "id": "E1BBW2", "url": "https://omabrowser.org/oma/group/E1BBW2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBW2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 913, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBW2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBW2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 448, "end_pos": 450 }, { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A7MB76-1", "uniprot_ac": "A7MB76", "uniprot_id": "TPC13_BOVIN", "mass": { "chemical_mass": 46547.0, "monoisotopic_mass": 46547.0 }, "refseq": { "ac": "NP_001095410", "name": "trafficking protein particle complex subunit 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410" }, "gene_names": [ { "name": "TRAPPC13", "type": "recommended", "evidence": [ { "id": "A7MB76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB76" } ] }, { "name": "C20H5orf44", "type": "synonym", "evidence": [ { "id": "NP_001095410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410" } ] }, { "name": "TRAPPC13", "type": "synonym", "evidence": [ { "id": "NP_001095410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 13", "type": "recommended", "evidence": [ { "id": "A7MB76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB76/entry#names_and_taxonomy" } ] }, { "name": "UPF0533 protein C5orf44 homolog", "type": "synonym", "evidence": [ { "id": "NP_001095410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410" } ] }, { "name": "trafficking protein particle complex 13", "type": "synonym", "evidence": [ { "id": "NP_001095410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410" } ] }, { "name": "trafficking protein particle complex subunit 13", "type": "synonym", "evidence": [ { "id": "NP_001095410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410" } ] } ], "function": [ { "annotation": "Component of the multisubunit TRAPP (transport protein particle) III complex (By similarity). As a component of TRAPPIII complex, participates in the activation of RAB1 and RAB43, but not RAB11A, RAB11B, nor RAB19 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A7MB76", "url": "https://www.uniprot.org/uniprotkb/A7MB76#function" }, { "database": "UniProtKB", "id": "A5PLN9", "url": "https://www.uniprot.org/uniprotkb/A5PLN9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB76", "url": "https://www.uniprot.org/uniprotkb/A7MB76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC13", "url": "https://www.uniprot.org/uniprotkb/A7MB76", "locus": { "chromosome": "20", "start_pos": 13903927, "end_pos": 13938339, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016900", "url": "https://www.ensembl.org/id/ENSBTAG00000016900" } ] } } ], "crossref": [ { "id": "A7MB76", "url": "https://alphafold.ebi.ac.uk/entry/A7MB76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016900", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016900", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511108", "url": "https://www.ncbi.nlm.nih.gov/gene/511108", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511108", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511108", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YLCVHNG", "url": "https://omabrowser.org/oma/group/YLCVHNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB76", "url": "https://www.orthodb.org/?gene=A7MB76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13134:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13134:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095410", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGC7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z358", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z358", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z358-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z358-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB76", "url": "https://www.uniprot.org/uniprotkb/A7MB76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB76-1", "url": "https://www.uniprot.org/uniprotkb/A7MB76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQSGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNSVNQAGECVTTFGSRAYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES", "length": 417, "header": "sp|A7MB76-1|TPC13_BOVIN Isoform 1 of Trafficking protein particle complex subunit 13 OS=Bos taurus OX=9913 GN=TRAPPC13 PE=2 SV=1 CANONICAL=A7MB76-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGC7/entry", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQSGEKMYFRKFFKFQVLKPLDVKTKFYNAETDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNSVNQAGECVTTFGSRAYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCRSSVSSSIKMGLLPTHNTHRHIPVICSYWIFVECNEESHALHLNWAVAHTEHFKF", "length": 381, "header": "tr|A0A3Q1MGC7-1|TPC13_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 13 OS=Bos taurus OX=9913 GN=TRAPPC13 PE=2 SV=2 CANONICAL=A7MB76-1" }, "locus": { "chromosome": "20", "start_pos": 13938073, "end_pos": 13905861, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082584.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082584.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073304.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073304.2" } ] } }, { "isoform_ac": "A0AAA9SYD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD3/entry", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQSGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNSVNQAGECVTTFGSRAYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCRSSVSSSIKMGLLPTHNTHRHIPVICSYWIFVECNEESHALHLNWAVAHTEHFKF", "length": 387, "header": "tr|A0AAA9SYD3-1|TPC13_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 13 OS=Bos taurus OX=9913 GN=TRAPPC13 PE=2 SV=1 CANONICAL=A7MB76-1" }, "locus": { "chromosome": "20", "start_pos": 13938073, "end_pos": 13905861, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113209.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113209.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089102.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089102.1" } ] } }, { "isoform_ac": "A0AAF6Z358-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z358/entry", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQSGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNSVNQAGECVTTFGSRAYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES", "length": 418, "header": "tr|A0AAF6Z358-1|TPC13_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 13 OS=Bos taurus OX=9913 GN=TRAPPC13 PE=2 SV=1 CANONICAL=A7MB76-1" }, "locus": { "chromosome": "20", "start_pos": 13938073, "end_pos": 13904075, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022480.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022480.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022480.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022480.6" } ] } }, { "isoform_ac": "A7MB76-1", "url": "https://www.uniprot.org/uniprotkb/A7MB76/entry#A7MB76-1", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQSGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNSVNQAGECVTTFGSRAYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES", "length": 417, "header": "sp|A7MB76-1|TPC13_BOVIN Isoform 1 of Trafficking protein particle complex subunit 13 OS=Bos taurus OX=9913 GN=TRAPPC13 PE=2 SV=1 CANONICAL=A7MB76-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511108", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511108", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YM10-1", "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "TRAPPC13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDVNQPKQEHLLALKVMRLTKPTLFTNIPVTCEERDLPGNLFNQLMKDDPSTVKGAEALMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASTAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNTVDSAGESESTFGSRTYLQPMDTRQYLYCLKPKQEFAEKAGVIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLETIPDTVNLEEPFDITCKITNCSSERTMDLVLEMCNTNSIHWCGVSGRQLGKLHPSSSLRLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSSKVKQES", "length": 418 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A5PLN9-1", "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "TRAPPC13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMRDDPSTVNGAEVLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNMTTSPMFMEKVSLEPSIMYNVTELNSVSQAGECVSTFGSRAYLQPMDTRQYLYCLKPKNEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERTMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVSSAIKVES", "length": 417 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O82263-1", "protein_name": "Trafficking protein particle complex subunit-like protein", "gene_name": "TRAPPC13", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSATQTQTHGPHSLAFRVMRLCKPSFHVDPPLRIDPFDLLAGEDFSDDPSSASLFRRHVSSADAVDSDLSYRNRFLLNHPTDPIGLSGLLLLPQSFGAIYLGETFCSYISVNNSSTSEVRDVTIKAEIQTERQRILLLDTSKSPVESIRTGGRYDFIVEHDVKELGAHTLVCSALYNDADGERKYLPQFFKFVVANPLSVRTKVRVVKETTFLEACIENHTKANLFMDQVDFEPAKQWSAVRLQNEDSTEDPPTSGLSGLIPKPPVIIRSGGGIHNYLYKLNPSADVSGQTKFQGSNILGKFQITWRTNLGEPGRLQTQQILGAPVSRKEINMRVVEVPAVIHLNRPFRAYLNLTNQTDRQLGPFEVSLSQDETQLEKPVGINGLQTLMLPRIEAFGSNDFQLNLIASKLGVQKIAGITALDTREKKTYELVPDMEIFVETD", "length": 442 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q3TIR1-1", "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "Trappc13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMKDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQGGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVTELNSVTQAGECISTFGSRGYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSERMMDLVLEMCNTNSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSAAVEVEA", "length": 417 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q55EX6-1", "protein_name": "Trafficking protein particle complex subunit 13 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKENHLLNLKVMRLSKPNIPTINPILCEKQDLPYETMSTSIDSTSLSMGSVNSSGSNDNNQLIGNNGNPINMEGLGVTSMLQLQSGVIYLGEMFCCYISLNNHSPYQVRNVFLKVELQTTSSRIPLLDSEQQSVPTFNPGFSSDFVVQREVKESGVNILVCAVNYTTPEGEQKKFRKYFKFQVLNPLVLKTRIHNLPNVVFLEACLENATQGSLFIESILFEPIEHFNSKDISFENSLDDNNNLDNNNNNLENDNNLNNLEFKLNEKGLIENTDELLENIKLTTSDNIVFLKQGCSRQYLFQITPKDIENVESKNSLPLGRLDITWRSYFGEIGRLKTAAIQRKLNQEDIECSLINIPDKIKLEKPFSVIAKLSNKSNRILYPQFMLVRNKMDGIKINSHLPKLDPIQPNSIIQVEIEMFPLKPGMQQIIGLAIKLLDPPVIGITPTTSSSQQQQPISKPTLGQVLQQTQQSQIQQQQQQQNQQLQPPKNFYEFNAVDTWVEFADSKLVDI", "length": 511 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5M887-1", "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "Trappc13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVNPPKQEHLLALKVMRLTKPTLFTNIPVTCEEKDLPGDLFNQLMKDDPSTVNGAEILMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASNAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQGGEKMYFRKFFKFQVLKPLDVKTKFYNAESDLSSVTDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVTELNSVNQAGECVSTFGSRGYLQPMDTRQYLYCLKPKKEFAEKAGIIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEAIPDTVNLEEPFHITCKITNCSSERTMDLVLEMCNTTSIHWCGISGRQLGKLHPSSSLCLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSAAVEVEA", "length": 418 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PBY7-1", "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "trappc13", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDVNQAKQEHLLALKVMRLTKPTLFTNMPVTCEDRDLPGDLFLRLMKDDPSTVKGAETLILGEMLTLPQNFGNIFLGETFSSYISVHNDSSQVVKDILVKADLQTSSQRLNLSASNSAVSELKPECCIDDVIHHEVKEIGTHILVCAVSYTTQTGEKLYFRKFFKFQVLKPLDVKTKFYNAETDEVFLEAQIQNITTSPMFMEKVSLEPSMMYNVTELNNVASGDESSESTFGKMSYLQPLDTRQYLYCLKPKPEFAEKAGVIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLEFIPDTVDLEEPFDITCKITNCSERTMDLLLEMCNTRSVHWCGVSGRQLGKLSPSASLSIPLKLLSSVQGLQSISGLRLTDTFLKRTYEYDDIAQVCVVCPYTSPES", "length": 412 }, "evidence": [ { "id": "A7MB76", "url": "https://omabrowser.org/oma/group/A7MB76/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "TRAPPIII protein complex", "id": "GO:1990072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990072", "evidence": [ { "database": "UniProtKB", "id": "A7MB76", "url": "https://www.uniprot.org/uniprotkb/A7MB76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB76-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 417, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB76-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB76" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B764-1", "uniprot_ac": "E1B764", "uniprot_id": "E1B764_BOVIN", "mass": { "chemical_mass": 48813.0, "monoisotopic_mass": 48813.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1B764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B764/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B764", "url": "https://www.uniprot.org/uniprotkb/E1B764" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B764", "locus": {} } ], "crossref": [ { "id": "E1B764", "url": "https://alphafold.ebi.ac.uk/entry/E1B764", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049932", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049932", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000055058", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000055058", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11738:SF179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11738:SF179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MLE9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B764", "url": "https://www.uniprot.org/uniprotkb/E1B764", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B764-1", "url": "https://www.uniprot.org/uniprotkb/E1B764-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRAAWSSQRGSLGGLAESWGLVGTPGEPASDFLPGTLPKPTIWAEPGSVVPSGTPVTIWCQGTLETQVFHLDKEGTSVPWDRQKPPGPGDKAQLAIPQMTEQHAGSYRCYYSTPTGWSEGSDRLELVVTGSYSKPSLSALPSPVVTLGGSVTLQCDSHQGFNRFLLTKEGEDESSRTLDGQRAPNWQTQALFSVGPVTPGHRWMFRCYGFYRDTPQVWSAPSDPLELLVSGLSGKPSLLTSQGPVITSGQNLTLQCRSDVSYARFALSKEGGQDLPQRPARRPQEGLSQADFPLGPVSTVQGGRYRCYGGHGLSSEWSAPSEPLELLVAGEEPADRPSLSVRPGPTVAPGENVTLLCQSGNRTDTFLLFKEGRAVPGRVLLEPCDLSPRGTYRCYGSLSTDPYLLSQPSEPLALVVSGEAQSVQQEASVLLGASSGGAQGAHGPGSSPGSATSRLGHQGP", "length": 461, "header": "tr|E1B764-1|E1B764_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B764-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE9/entry", "sequence": { "sequence": "PRRELSVLLHWGLVGTPGEPASDFLPGTLPKPTIWAEPGSVVPSGTPVTIWCQGTLETQVFHLDKEGTSVPWDRQKPPGPGDKAQLAIPQMTEQHAGSYRCYYSTPTGWSEGSDRLELVVTGSYSKPSLSALPSPVVTLGGSVTLQCDSHQGFNRFLLTKEGEDESSRTLDGQRAPNWQTQALFSVGPVTPGHRWMFRCYGFYRDTPQVWSAPSDPLELLVSGEESHPEPIHLCRQDNLPGSLLPGELCTETGSGRGETLRNRDCAEGPERPTESRSEPGPAPAPPSSLQDGSETDPPSRCGRAPRWPPGRM", "length": 312, "header": "tr|A0A3Q1MLE9-1|E1B764_BOVIN Computationally mapped isoform of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=3 CANONICAL=E1B764-1" }, "locus": { "chromosome": "NKLS02000591.1", "start_pos": 230975, "end_pos": 228586, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084309.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084309.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072513.3", "url": "https://www.ensembl.org/id/ENSBTAP00000072513.3" } ] } }, { "isoform_ac": "E1B764-1", "url": "https://www.uniprot.org/uniprotkb/E1B764/entry", "sequence": { "sequence": "MGRAAWSSQRGSLGGLAESWGLVGTPGEPASDFLPGTLPKPTIWAEPGSVVPSGTPVTIWCQGTLETQVFHLDKEGTSVPWDRQKPPGPGDKAQLAIPQMTEQHAGSYRCYYSTPTGWSEGSDRLELVVTGSYSKPSLSALPSPVVTLGGSVTLQCDSHQGFNRFLLTKEGEDESSRTLDGQRAPNWQTQALFSVGPVTPGHRWMFRCYGFYRDTPQVWSAPSDPLELLVSGLSGKPSLLTSQGPVITSGQNLTLQCRSDVSYARFALSKEGGQDLPQRPARRPQEGLSQADFPLGPVSTVQGGRYRCYGGHGLSSEWSAPSEPLELLVAGEEPADRPSLSVRPGPTVAPGENVTLLCQSGNRTDTFLLFKEGRAVPGRVLLEPCDLSPRGTYRCYGSLSTDPYLLSQPSEPLALVVSGEAQSVQQEASVLLGASSGGAQGAHGPGSSPGSATSRLGHQGP", "length": 461, "header": "tr|E1B764-1|E1B764_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B764-1" }, "locus": { "chromosome": "NKLS02000591.1", "start_pos": 232328, "end_pos": 229337, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055877.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055877.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052395.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052395.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 199, "start_aa": "Thr", "end_pos": 199, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr199", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 347, "start_aa": "Thr", "end_pos": 347, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr347", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B764", "url": "https://www.uniprot.org/uniprotkb/E1B764" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1B764", "url": "https://www.uniprot.org/uniprotkb/E1B764" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B764" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 130, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 199, 347 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 252, "end_pos": 254 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 362, "end_pos": 364 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8Q9-1", "uniprot_ac": "E1B8Q9", "uniprot_id": "E1B8Q9_BOVIN", "mass": { "chemical_mass": 119858.0, "monoisotopic_mass": 119858.0 }, "refseq": { "ac": "NP_001193049", "name": "importin-8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193049" }, "gene_names": [ { "name": "IPO8", "type": "recommended", "evidence": [ { "id": "E1B8Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ] }, { "name": "IPO8", "type": "synonym", "evidence": [ { "id": "NP_001193049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193049" } ] } ], "protein_names": [ { "name": "Importin 8", "type": "synonym", "evidence": [ { "id": "E1B8Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9/entry#names_and_taxonomy" } ] }, { "name": "importin-8", "type": "synonym", "evidence": [ { "id": "NP_001193049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193049" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IPO8", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9", "locus": { "chromosome": "5", "start_pos": 78920921, "end_pos": 78855639, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014106", "url": "https://www.ensembl.org/id/ENSBTAG00000014106" } ] } } ], "crossref": [ { "id": "E1B8Q9", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Q9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014106", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014106", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523408", "url": "https://www.ncbi.nlm.nih.gov/gene/523408", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058669", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058669", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523408", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523408", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNFEYRS", "url": "https://omabrowser.org/oma/group/KNFEYRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIF3", "url": "https://www.orthodb.org/?gene=A0A3Q1MIF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8Q9", "url": "https://www.orthodb.org/?gene=E1B8Q9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10997:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10997:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08506", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08506", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5578749", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5578749", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193049", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIF3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIF3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Q9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSEHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKYDFPGHWPAVVDKIDYYLQSQSSGSWLGSLLCLYQLVKTYEYKKAEEREPLIAAMQIFLPRIQQQIMQLLPDSSHYSVLIQKQILKIFYALVQYALPLQLVNNQTMTAWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGIVHSVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLADILLKKSLFKDQMELLLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVDLAKKSLIEDKEMPVKVEAALALQSLISNQTQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEVTQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHGISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTNTLLSNPKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPVTVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDHSKADKANIEENEEISSDEEETNVTAQAMQSNNGRGEDEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLMAPLSEDQRRALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTMPTNN", "length": 1037, "header": "tr|E1B8Q9-1|E1B8Q9_BOVIN Isoform 1 of Importin 8 OS=Bos taurus OX=9913 GN=IPO8 PE=3 SV=2 CANONICAL=E1B8Q9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIF3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIF3/entry", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSEHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRYKKAEEREPLIAAMQIFLPRIQQQIMQLLPDSSHYSVLIQKQILKIFYALVQYALPLQLVNNQTMTAWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGIVHSVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLADILLKKSLFKDQMELLLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVDLAKKSLIEDKEMPVKVEAALALQSLISNQTQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEVTQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHGISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTNTLLSNPKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPVTVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDHSKADKANIEENEEISSDEEETNVTAQAMQSNNGRGEDEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLMAPLSEDQRRALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTMPTNN", "length": 984, "header": "tr|A0A3Q1MIF3-1|E1B8Q9_BOVIN Computationally mapped isoform of Importin 8 OS=Bos taurus OX=9913 GN=IPO8 PE=3 SV=1 CANONICAL=E1B8Q9-1" }, "locus": { "chromosome": "5", "start_pos": 78920463, "end_pos": 78855928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077888.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077888.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074084.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074084.1" } ] } }, { "isoform_ac": "A0AAA9SX75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX75/entry", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSEHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKYDFPGHWPAVVDKIDYYLQSQSSGSWLGSLLCLYQLVKTYEYKKAEEREPLIAAMQIFLPRIQQQIMQLLPDSSHYSVLIQKQILKIFYALVQETLQIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGIVHSVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLADILLKKSLFKDQMELLLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVDLAKKSLIEDKEMPVKVEAALALQSLISNQTQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEVTQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHGISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTNTLLSNPKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPVTVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDHSKADKANIEENEEISSDEEETNVTAQAMQSNNGRGEDEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLMAPLSEDQRRALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTMPTNN", "length": 1007, "header": "tr|A0AAA9SX75-1|E1B8Q9_BOVIN Computationally mapped isoform of Importin 8 OS=Bos taurus OX=9913 GN=IPO8 PE=3 SV=1 CANONICAL=E1B8Q9-1" }, "locus": { "chromosome": "5", "start_pos": 78920463, "end_pos": 78855928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097560.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097560.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087893.1" } ] } }, { "isoform_ac": "E1B8Q9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9/entry", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSEHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKYDFPGHWPAVVDKIDYYLQSQSSGSWLGSLLCLYQLVKTYEYKKAEEREPLIAAMQIFLPRIQQQIMQLLPDSSHYSVLIQKQILKIFYALVQYALPLQLVNNQTMTAWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGIVHSVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLADILLKKSLFKDQMELLLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVDLAKKSLIEDKEMPVKVEAALALQSLISNQTQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEVTQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHGISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTNTLLSNPKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPVTVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDHSKADKANIEENEEISSDEEETNVTAQAMQSNNGRGEDEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLMAPLSEDQRRALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTMPTNN", "length": 1037, "header": "tr|E1B8Q9-1|E1B8Q9_BOVIN Isoform 1 of Importin 8 OS=Bos taurus OX=9913 GN=IPO8 PE=3 SV=2 CANONICAL=E1B8Q9-1" }, "locus": { "chromosome": "5", "start_pos": 78920463, "end_pos": 78855928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018760.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018760.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018760.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018760.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523408", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523408", "resource": "KEGG Pathway" }, { "id": "R-BTA-5578749", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5578749", "resource": "Reactome", "description": "Transcriptional regulation by small RNAs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K6J6-1", "protein_name": "Importin 8", "gene_name": "Ipo8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAETELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEVIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRVIIRHDFPGHWPAVVDKIDYYLKSPNSGNWLGSLLCLYQLVKTYEYKKAEEREPLLAAMQIFLPRIQQQILQLLPDASHYSVLLQKQILKIFYALVQYALPLQLVNHQTMTTWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVTRLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYIAPRVLQQALNYLNQGVVHAVTWKQMKPHMQNISEDVIFSVMCYKDEDEELWQEDPYEYIRVKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQIELFLQNHVFPLILSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIEDLEMPVKVEAALALQSLISNQTQAKEYMKPYVRFIMQELLHIVKETESDDVTNVIQKLICEYSHDMASIAVDITQHLAEIFGKVLQSDEYEEIEDKTVMAMGILHTIDTILTVVEDHPEIIQQLENICLRIIDLVLQKHVIEFYEEILSLAYNLTCHAISPQMWQLLGILFEVFQQDCFEYFTDMMPLLHNYVTVDTNALLSNPKHLEVLFTMCRKVLCGESGEDAECYAAKLLEVIILQCKGRGIDQCIPLFIQLVLERLTRGVKTSELRTMCLQVAIAALYYSPELLFHTLERVQLPHNPGPVTSQFINQWMSDTDYFLGHHDRKMCIIGLSVLLELQNRPPAVDAVAAQILPSILFLFLGLKQVCATRQTVNRENHSKAEKADIEENEEISSEEEEETSVNAQAMQSQICRGEEEEDDDWDEEVVEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLVAPLSEDQKRKLQEVYTLAEHRRTLAGQFHI", "length": 1009 }, "evidence": [ { "id": "E1B8Q9", "url": "https://omabrowser.org/oma/group/E1B8Q9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8D0N8A8-1", "protein_name": "Importin 8", "gene_name": "IPO8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKYDFPGHWPAVVDKIDYYLQSQSSGSWLGSLLCLYQLVKTYEYKKAEEREPLIAAMQIFLPRIQQQIMQLLPDSSHYSVLLQKQILKIFYALVQYALPLQLVNNQTMTAWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGIVHSVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLADILLKKSLFKDQMELLLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVDLAKKSLIEDKEMPVKVEAALALQSLISNQTQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEVTQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHGISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTSTLLSNPKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPVTVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVAQIVPSILFLFLGLKQVCATRQLVNREDRSKVEKTDMEENEEISSDEEETNVTAQAMQSNNGRGEDEEEDDDDWDEEVLEETALEGFSTPLDLDSSVDEYQFFTQALLTVQNRDAAWYQLLMAPLSEDQRRALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTMPTNN", "length": 1037 }, "evidence": [ { "id": "E1B8Q9", "url": "https://omabrowser.org/oma/group/E1B8Q9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A5WW24-1", "protein_name": "Importin-8", "gene_name": "ipo8", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDPNRIIQALKGTIDPNLRLAAENELNQSYKIINFAPTLLQIIVSEQVEFPVRQAAAIYLKNMVSQYWQDREPTLGEVVFPFNIHENDRGQIRENMVEAIIRCPESIRAQLTVCLRAIIKHDFPGRWTGVVDKINLYLQSQNSGSWYGSLLALYQLVKNYEFKKAEERDPLLAAMQIFLPRLQQLITQLLSDATFISVLIQKQILKIFHALVQLINNTVMTHWMEILRTVVDRDVPAIWFSECLRGGFQETLEADEDDRPELIWWKCKKWALHILTRIFERYGSPGNVTKEYVEFADFFLKTYALGIQQVLLKVMEQHRQRQYVSPRVLQQTLSFMTQGVSHSLTWRQMKPHMQTITHELVFPLMCYKDEDERLWQEDPYEYIRMKFNVYDDHVSPATAAQTLLCTAARKRKEVLPQMMEFCHQILVDPSADPRRTDGALHVIGTLAQPLLKKRVYRDQMELMLQNYVFPLLNSNLAYLRARSCWVLHSFSPLKFHNELVLRNAVELVKHNLVEDKEMPVKVEAAIALQTLVRNQEQAKVYIRPFIRPVMQELLHIIKETENDDLTGVIQKMICEYSEEVTVIAVDMTQNLAEIFSKILQSEEYEESEDKTVMALGILSTIDTILTVMGDRKEISQQLEGICLQVIGLVLQKPIIGMAEFYEEILSLAFGLTCYCISPQMWQLLGVLYDVFQHDCFDYFTDMMPLLHNYVTVDTNMLLSDPKYLEVIYTMCKKVLTSDAGEDPECHAAKLLEVIILQCRGRGIDQCIPLFVEAVLERLTRGVKSSELRTMCLQVVIAALYYNPTLLIHTLENIRFPHSPEPITAQFINQWMNDTEFFLGLHDRKMCVIGLSILMELPSRPAVLEEVVGQIVPSVLLLFLGLKHIYASRVLNKPEQFGRAQGSEEEENEEIPSDEDEVGEKGVALQPSVAPTGNDNEDDDDEDDDEYWDDEGLEGTPLEEYSTPLDCDNGEDEYQFFTASLLRVQSSDAGWYQSLTSPLNEDQRKQLQEIYNLAQQRRSTGVKGL", "length": 1024 }, "evidence": [ { "id": "E1B8Q9", "url": "https://omabrowser.org/oma/group/E1B8Q9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O15397-1", "protein_name": "Importin-8", "gene_name": "IPO8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKHDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLPRIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQYALPLQLVNNQTMTTWMEIFRTIIDRTVPPETLHIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGVVHSITWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQMELFLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIEDKEMPVKVEAALALQSLISNQIQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEITQQLENICLRIIDLVLQKHVIEFYEEILSLAYSLTCHSISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTDTLLSNAKHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPITVQFINQWMNDTDCFLGHHDRKMCIIGLSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDRSKAEKADMEENEEISSDEEETNVTAQAMQSNNGRGEDEEEEDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALITVQSRDAAWYQLLMAPLSEDQRTALQEVYTLAEHRRTVAEAKKKIEQQGGFTFENKGVLSAFNFGTVPSNN", "length": 1037 }, "evidence": [ { "id": "E1B8Q9", "url": "https://omabrowser.org/oma/group/E1B8Q9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TMY7-1", "protein_name": "Importin-8", "gene_name": "Ipo8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLNRIIQALKGTIDPKLRIAAETELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEVIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRVIIRHDFPGHWPAVVDKIDYYLQSPNSGSWLGSLLCLYQLVKTYEYKKAEEREPLLAAMQIFLPRIQQQILQLLPDASHYSVLLQKQILKIFYALVQYALPLQLVNHQTMTTWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYIAPRVLQQAFNYLNQGVVHAVTWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQIELFLQNHVFPLLMSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIEDEEMPVKVEAALALQSLISNQAQAKEHMKPYVRFIMQELLHIVRETENDDVTNVIQKLICEYSQDVASIAVDTTQHLAEIFGKVLQSDEYEEIEDKTVMAMGILHTIDTILTVVEDHPEIIQQLENICLRIIDLVLQKHVIEFYEEILSLAYNLTCHTISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTVDTNALLSNPKHLEVLFTMCRKVLCGEAGEDAECYAAKLLEVIILQCKGRGIDQCIPLFIQLVLERLTRGVKTSELRTMCLQVAIAALYYSPELLFHTLEQVQLPHNPGPVTSQFINQWMNDTDYFLGHHDRKMCIIGLSVLLELQNRPPAVDAVAAQILPSILFLFLGLKQVCATRQTVNRENHSKAEKVDIEENEEISSEEEEETSVSAQAMQSQIGRSEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDAAWYQLLVAPLSEDQKRKLQEVYTLAEHRRTLAAGQFHI", "length": 1010 }, "evidence": [ { "id": "E1B8Q9", "url": "https://omabrowser.org/oma/group/E1B8Q9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" }, { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q9", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 528, "end_pos": 530, "annotation": "n_glycosylation_sequon" }, { "start_pos": 823, "end_pos": 825, "annotation": "n_glycosylation_sequon" }, { "start_pos": 909, "end_pos": 911, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Q9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1037, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Q9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Q9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q9" }, { "id": "PS50166", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50166" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Importin N-terminal", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 102, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 223, "end_pos": 225 }, { "start_pos": 27, "end_pos": 29 }, { "start_pos": 281, "end_pos": 283 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 528, "end_pos": 530 }, { "start_pos": 823, "end_pos": 825 }, { "start_pos": 909, "end_pos": 911 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B898-1", "uniprot_ac": "E1B898", "uniprot_id": "E1B898_BOVIN", "mass": { "chemical_mass": 57625.0, "monoisotopic_mass": 57625.0 }, "refseq": {}, "gene_names": [ { "name": "KRT86", "type": "recommended", "evidence": [ { "id": "E1B898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B898" } ] } ], "protein_names": [ { "name": "Keratin 86", "type": "synonym", "evidence": [ { "id": "E1B898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B898/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B898", "url": "https://www.uniprot.org/uniprotkb/E1B898" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT86", "url": "https://www.uniprot.org/uniprotkb/E1B898", "locus": { "chromosome": "5", "start_pos": 27585435, "end_pos": 27592813, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013720", "url": "https://www.ensembl.org/id/ENSBTAG00000013720" } ] } } ], "crossref": [ { "id": "E1B898", "url": "https://alphafold.ebi.ac.uk/entry/E1B898", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013720", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013720", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MKM0", "url": "https://www.orthodb.org/?gene=A0A3Q1MKM0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B898", "url": "https://www.orthodb.org/?gene=E1B898", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MKM0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKM0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B898", "url": "https://www.uniprot.org/uniprotkb/E1B898", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B898-1", "url": "https://www.uniprot.org/uniprotkb/E1B898-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTSHGWYGRSRSPAFLRPPFQRRLPPESLPCPQRNTMTCGSYRALPAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSVCGGFRAGYCGRSFGYRSGGVGGLSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFYQNRQCCESNLEPLFNGYIETLRREAECVEADSGRLSSELNSLQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAHYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRTIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASGAAPAVTTSVCSAPCSGNVVVGTSDACGPCSRVGGSILGCKKC", "length": 523, "header": "tr|E1B898-1|E1B898_BOVIN Isoform 1 of Keratin 86 OS=Bos taurus OX=9913 GN=KRT86 PE=3 SV=2 CANONICAL=E1B898-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MKM0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKM0/entry", "sequence": { "sequence": "MTCGSYRALPAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSVCGGFRAGYCGRSFGYRSGGVGGLSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFYQNRQCCESNLEPLFNGYIETLRREAECVEADSGRLSSELNSLQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAHYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRTIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRWVLSSRGGVVCGDLCASGAAPAVTTSVCSAPCSGNVVVGTSDACGPCSRVGGSILGCKKC", "length": 476, "header": "tr|A0A3Q1MKM0-1|E1B898_BOVIN Computationally mapped isoform of Keratin 86 OS=Bos taurus OX=9913 GN=KRT86 PE=3 SV=1 CANONICAL=E1B898-1" }, "locus": { "chromosome": "5", "start_pos": 27577313, "end_pos": 27570750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081840.1", "url": "https://www.ensembl.org/id/ENSBTAT00000081840.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072104.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072104.1" } ] } }, { "isoform_ac": "E1B898-1", "url": "https://www.uniprot.org/uniprotkb/E1B898/entry", "sequence": { "sequence": "MSTSHGWYGRSRSPAFLRPPFQRRLPPESLPCPQRNTMTCGSYRALPAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSVCGGFRAGYCGRSFGYRSGGVGGLSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFYQNRQCCESNLEPLFNGYIETLRREAECVEADSGRLSSELNSLQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAHYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRTIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASGAAPAVTTSVCSAPCSGNVVVGTSDACGPCSRVGGSILGCKKC", "length": 523, "header": "tr|E1B898-1|E1B898_BOVIN Isoform 1 of Keratin 86 OS=Bos taurus OX=9913 GN=KRT86 PE=3 SV=2 CANONICAL=E1B898-1" }, "locus": { "chromosome": "5", "start_pos": 27592757, "end_pos": 27586005, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018307.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018307.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018307.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018307.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "E1B898", "url": "https://www.uniprot.org/uniprotkb/E1B898" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "E1B898", "url": "https://www.uniprot.org/uniprotkb/E1B898" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "E1B898", "url": "https://www.uniprot.org/uniprotkb/E1B898" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "E1B898", "url": "https://www.uniprot.org/uniprotkb/E1B898" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B898-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 523, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B898-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B898" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B898" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 143, "end_pos": 454, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 363, "end_pos": 365 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7C7-1", "uniprot_ac": "E1B7C7", "uniprot_id": "E1B7C7_BOVIN", "mass": { "chemical_mass": 30151.0, "monoisotopic_mass": 30151.0 }, "refseq": {}, "gene_names": [ { "name": "GZMK", "type": "recommended", "evidence": [ { "id": "E1B7C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ] } ], "protein_names": [ { "name": "Granzyme K", "type": "synonym", "evidence": [ { "id": "E1B7C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GZMK", "url": "https://www.uniprot.org/uniprotkb/E1B7C7", "locus": { "chromosome": "20", "start_pos": 24073111, "end_pos": 24095186, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005164", "url": "https://www.ensembl.org/id/ENSBTAG00000005164" } ] } } ], "crossref": [ { "id": "E1B7C7", "url": "https://alphafold.ebi.ac.uk/entry/E1B7C7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLR2", "url": "https://www.orthodb.org/?gene=A0A3Q1MLR2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7C7", "url": "https://www.orthodb.org/?gene=E1B7C7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MLR2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLR2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7C7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSNCCFLTCIQVSQVYETGSHHSALAGTYMTPECFNMEIIGGREVSPHSRPFMASLQYGGDHICGGVLIHPQWVLTAAHCHLRFAKSQSSKVVLGAHSLSKNEASKQTFEIKKFIRFPGFALAPKSNDIMLVKLHTAAILNRHVQLLHPRAKNDIKAGTKCQVVGWGATDPEGLSLSDTLREVTVTVISRKTCNSRDYYNHSPVITRTMLCAGDARGQKDSCQGDSGGPLVCKGAFHALVSGGPKCGDAKKPGIYILLTRKFQAWIKSNLAPSHAD", "length": 278, "header": "tr|E1B7C7-1|E1B7C7_BOVIN Isoform 1 of Granzyme K OS=Bos taurus OX=9913 GN=GZMK PE=4 SV=2 CANONICAL=E1B7C7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLR2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLR2/entry", "sequence": { "sequence": "MVPELWLLTQVYETGSHHSALAGTYMTPECFNMEIIGGREVSPHSRPFMASLQYGGDHICGGVLIHPQWVLTAAHCHLRFAKSQSSKVVLGAHSLSKNEASKQTFEIKKFIRFPGFALAPKSNDIMLVKLHTAAILNRHVQLLHPRAKNDIKAGTKCQVVGWGATDPEGLSLSDTLREVTVTVISRKTCNSRDYYNHSPVITRTMLCAGDARGQKDSCQGDSGGPLVCKGAFHALVSGGPKCGDAKKPGIYILLTRKFQAWIKSNLAPSHAD", "length": 272, "header": "tr|A0A3Q1MLR2-1|E1B7C7_BOVIN Computationally mapped isoform of Granzyme K OS=Bos taurus OX=9913 GN=GZMK PE=4 SV=2 CANONICAL=E1B7C7-1" }, "locus": { "chromosome": "20", "start_pos": 24095045, "end_pos": 24073473, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071556.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071556.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071999.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071999.2" } ] } }, { "isoform_ac": "E1B7C7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C7/entry", "sequence": { "sequence": "MSSSNCCFLTCIQVSQVYETGSHHSALAGTYMTPECFNMEIIGGREVSPHSRPFMASLQYGGDHICGGVLIHPQWVLTAAHCHLRFAKSQSSKVVLGAHSLSKNEASKQTFEIKKFIRFPGFALAPKSNDIMLVKLHTAAILNRHVQLLHPRAKNDIKAGTKCQVVGWGATDPEGLSLSDTLREVTVTVISRKTCNSRDYYNHSPVITRTMLCAGDARGQKDSCQGDSGGPLVCKGAFHALVSGGPKCGDAKKPGIYILLTRKFQAWIKSNLAPSHAD", "length": 278, "header": "tr|E1B7C7-1|E1B7C7_BOVIN Isoform 1 of Granzyme K OS=Bos taurus OX=9913 GN=GZMK PE=4 SV=2 CANONICAL=E1B7C7-1" }, "locus": { "chromosome": "20", "start_pos": 24091269, "end_pos": 24073473, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006807.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006807.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006807.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006807.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "glycosaminoglycan binding", "id": "GO:0005539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005539", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "positive regulation of release of cytochrome c from mitochondria", "id": "GO:0090200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090200", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "zymogen activation", "id": "GO:0031638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031638", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "opsonization", "id": "GO:0008228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008228", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "granzyme-mediated programmed cell death signaling pathway", "id": "GO:0140507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140507", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "complement activation, GZMK pathway", "id": "GO:0160257", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160257", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" }, { "name": "symbiont cell surface", "id": "GO:0106139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106139", "evidence": [ { "database": "UniProtKB", "id": "E1B7C7", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7C7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 278, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7C7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7C7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C7" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 273, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B735-1", "uniprot_ac": "E1B735", "uniprot_id": "E1B735_BOVIN", "mass": { "chemical_mass": 75636.0, "monoisotopic_mass": 75636.0 }, "refseq": { "ac": "NP_001192484", "name": "xaa-Pro aminopeptidase 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192484" }, "gene_names": [ { "name": "XPNPEP2", "type": "recommended", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] }, { "name": "XPNPEP2", "type": "synonym", "evidence": [ { "id": "NP_001192484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192484" } ] } ], "protein_names": [ { "name": "Xaa-Pro aminopeptidase 2", "type": "recommended", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735/entry#names_and_taxonomy" } ] }, { "name": "3.4.11.9", "type": "synonym", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735/entry#names_and_taxonomy" } ] }, { "name": "Membrane-bound aminopeptidase P", "type": "synonym", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735/entry#names_and_taxonomy" } ] }, { "name": "xaa-Pro aminopeptidase 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192484" } ] } ], "function": [ { "annotation": "Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735#function" }, { "database": "UniProtKB", "id": "ARBA00054204", "url": "https://www.uniprot.org/uniprotkb/ARBA00054204#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XPNPEP2", "url": "https://www.uniprot.org/uniprotkb/E1B735", "locus": { "chromosome": "X", "start_pos": 13802300, "end_pos": 13775781, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010345", "url": "https://www.ensembl.org/id/ENSBTAG00000010345" } ] } } ], "crossref": [ { "id": "E1B735", "url": "https://alphafold.ebi.ac.uk/entry/E1B735", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010345", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010345", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01085", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01085", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504822", "url": "https://www.ncbi.nlm.nih.gov/gene/504822", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032416", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032416", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504822", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504822", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LTHFRYT", "url": "https://omabrowser.org/oma/group/LTHFRYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM34", "url": "https://www.orthodb.org/?gene=A0A3Q1MM34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B735", "url": "https://www.orthodb.org/?gene=E1B735", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43763:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43763:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192484", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM34", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B735-1", "url": "https://www.uniprot.org/uniprotkb/E1B735-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWARWGGHPWLVLLCAYAWGHPKSLDQREDVRNCSSSPPYLPVTAVNTTAQLTALRQQMYTQNLSAYIVPDTDAHMSEYIGEYDQRRAWITGFTGSAGVAVVTMEKASLWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPVGARVGVDPFLFSINSWESYDKALQDSDRELVSITVNLVDLVWGSERPPVPSEPIYALQEAFTGSTWQEKVAGIRSQMQKHHKAPTAVLLSALDETAWLFNLRGSDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLQYLNSSCTGPLCVQVEDYGQVRDSVQAYTSGDVKVWIGTSYTSYGLYEVIPKEKLLEDTYSPVMVTKAVKNSKEQTLLRASHVRDAVAVIRYLVWLEKNVPQGTVDEFSGAEQLEKFRGEEEFFSGSSFETISASGLNAALAHYSPTKELHRKLSSDEIYLVDSGGQYWDGTTDVTRTVHWGTPSAFQKEAYTRVLIGNIDLSRLVFPAATSGRMVEAFARKALWDVGLNYGHGTGHGIGNFLCVHEWPVGFQSSNIAMAKGMFTSIEPGYYLDGEFGIRLEDVALVVEAKTKYPGTYLTFEVVSLVPYDRNLIDVSLLSPEQLQYLNRYYQIIREKVGPELQRRQLQEEFSWLQWHTEPLTARAAPTASLAPLVTVSALAILGWSV", "length": 673, "header": "tr|E1B735-1|E1B735_BOVIN Isoform 1 of Xaa-Pro aminopeptidase 2 OS=Bos taurus OX=9913 GN=XPNPEP2 PE=3 SV=1 CANONICAL=E1B735-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MM34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM34/entry", "sequence": { "sequence": "MRVSKSCPGRSSPDVRALGPASRSLQSQDTWDTCACCAHRVAVVTMEKASLWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPVGARVGVDPFLFSINSWESYDKALQDSDRELVSITVNLVDLVWGSERPPVPSEPIYALQEAFTGSTWQEKVAGIRSQMQKHHKAPTAVLLSALDETAWLFNLRGSDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLQYLNSSCTGPLCVQVEDYGQVRDSVQAYTSGDVKVWIGTSYTSYGLYEVIPKEKLLEDTYSPVMVTKAVKNSKEQTLLRASHVRDAVAVIRYLVWLEKNVPQGTVDEFSGAEQLEKFRGEEEFFSGSSFETISASGLNAALAHYSPTKELHRKLSSDEIYLVDSGGQYWDGTTDVTRTVHWGTPSAFQKEAYTRVLIGNIDLSRLVFPAATSGRMVEAFARKALWDVGLNYGHGTGHGIGNFLCVHEWPVGFQSSNIAMAKGMFTSIEPGYYLDGEFGIRLEDVALVVEAKTKYPGTYLTFEVVSLVPYDRNLIDVSLLSPEQLQYLNRYYQIIREKVGPELQRRQLQEEFSWLQWHTEPLTARAAPTASLAPLVTVSALAILGWSV", "length": 614, "header": "tr|A0A3Q1MM34-1|E1B735_BOVIN Computationally mapped isoform of Xaa-Pro aminopeptidase 2 OS=Bos taurus OX=9913 GN=XPNPEP2 PE=3 SV=2 CANONICAL=E1B735-1" }, "locus": { "chromosome": "X", "start_pos": 13801667, "end_pos": 13780067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077798.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077798.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070431.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070431.2" } ] } }, { "isoform_ac": "E1B735-1", "url": "https://www.uniprot.org/uniprotkb/E1B735/entry", "sequence": { "sequence": "MAWARWGGHPWLVLLCAYAWGHPKSLDQREDVRNCSSSPPYLPVTAVNTTAQLTALRQQMYTQNLSAYIVPDTDAHMSEYIGEYDQRRAWITGFTGSAGVAVVTMEKASLWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPVGARVGVDPFLFSINSWESYDKALQDSDRELVSITVNLVDLVWGSERPPVPSEPIYALQEAFTGSTWQEKVAGIRSQMQKHHKAPTAVLLSALDETAWLFNLRGSDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLQYLNSSCTGPLCVQVEDYGQVRDSVQAYTSGDVKVWIGTSYTSYGLYEVIPKEKLLEDTYSPVMVTKAVKNSKEQTLLRASHVRDAVAVIRYLVWLEKNVPQGTVDEFSGAEQLEKFRGEEEFFSGSSFETISASGLNAALAHYSPTKELHRKLSSDEIYLVDSGGQYWDGTTDVTRTVHWGTPSAFQKEAYTRVLIGNIDLSRLVFPAATSGRMVEAFARKALWDVGLNYGHGTGHGIGNFLCVHEWPVGFQSSNIAMAKGMFTSIEPGYYLDGEFGIRLEDVALVVEAKTKYPGTYLTFEVVSLVPYDRNLIDVSLLSPEQLQYLNRYYQIIREKVGPELQRRQLQEEFSWLQWHTEPLTARAAPTASLAPLVTVSALAILGWSV", "length": 673, "header": "tr|E1B735-1|E1B735_BOVIN Isoform 1 of Xaa-Pro aminopeptidase 2 OS=Bos taurus OX=9913 GN=XPNPEP2 PE=3 SV=1 CANONICAL=E1B735-1" }, "locus": { "chromosome": "X", "start_pos": 13801667, "end_pos": 13776127, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013664.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013664.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013664.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013664.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:504822", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504822", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "B1AVD1-1", "protein_name": "Xaa-Pro aminopeptidase 2", "gene_name": "Xpnpep2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQAYWQCYPWLVLLCACAWSYPEPKYLGREDVRNCSTSPERLPVTAVNTTMRLAALRQQMETWNLSAYIIPDTDAHMSEYIGKPDKRREWISGFTGSAGTAVVTMGKAAVWTDSRYWTQAERQMDCNWELHKEVSISSIVAWILAEVPDGQNVGFDPFLFSVDSWKNYDQGFQDSSRHLLSVTTNLVDVAWGSERPPVPSQPIYALPKEFTGSTWQEKVSAVRSYMEHHAKTPTGVLLSALDETAWLFNLRSSDIPYNPFFYSYALLTNSSIRLFVNKSRFSLETLQYLNTNCTLPMCVQLEDYSQVRDSVKAYASGDVKILIGVSYTTYGVYEVIPKEKLVTDTYSPVMLIKAVKNSKEQALLKSSHVRDAVAVIQYLVWLEKNVPKGTVDEFSGAEYIDELRRNENFSSGPSFETISASGLNAALAHYSPTKELHRKLSSDEMYLVDSGGQYWDGTTDITRTVHWGTPTAFQKEAYTRVLMGNIDLSRLVFPAATSGRVIEAFARRALWEVGLNYGHGTGHGIGNFLCVHEWPVGFQYNNIAMAKGMFTSIEPGYYHDGEFGIRLEDVALVVEAKTKYPGDYLTFELVSFVPYDRNLIDVRLLSPEQLQYLNRYYQTIRENVGPELQRRQLLEEFAWLEQHTEPLSARAPHIISWTSLWVASALAILSWSS", "length": 674 }, "evidence": [ { "id": "E1B735", "url": "https://omabrowser.org/oma/group/E1B735/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O43895-1", "protein_name": "Xaa-Pro aminopeptidase 2", "gene_name": "XPNPEP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV", "length": 674 }, "evidence": [ { "id": "E1B735", "url": "https://omabrowser.org/oma/group/E1B735/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6ZM25-1", "protein_name": "3.4.11.9", "gene_name": "xpnpep2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRTHSQDRDTCVPLSHSVCGLAWSRWSKMSSSGWILAVCLVVLGGEGHAVQAKERSGSERNCSANPPYLPPTAVNTTLRLRNIRASMIPLNISAYIIPATDAHLSEYIAPRDARLAWMSGFTGSAGTAVITQNKAVLWTDSRYWIQAQRQMDCNWELQQDSSIRSITNWLILEVPEGDQVGFDPFLFSVDTFDIYNTNLAPADLILKSISDNLVDKIWTDRPPLPPDNPTRLPDSVIERTWPMKVEQIRAQIIDNPYKPTAVLLSALDETAWLFNLRGNDVPYNPFFYSYTLLSMDDIWLFVHTERITEELKVYLNASCYQSLCVHLLEYSSVRTYLQSYLQRPNVRVWVGTEYTNQALYELITPEDKLLTSTYSPVLTTKAVKDMTEQRILKEAHVRDAVAVMQLLLWLEKKVPEGAETEITAALYADQCRSKQKNSRGPSFETISASGPNAALAHYSPSNDTARKLTVDEMYLVDSGGQYLDGTTDITRTVHWGKPTDFQKEAYTRVLMGNIEISRTIFPAGTRGVYMEMLGRRALWEVGLNYGHGTGHGVGNYFGVHEWPVGFQSNNIPFQEGMFTSIEPGYYKENDFGIRIEDIAVTVPASTKHSSKYLTFETVSLVPYDRNLIDTSLLNLEQLHWLNSYYETIRSLVGPELQKQGLKEEYDWMMKHTAPFLIAGASAVVSSITLFCTVLPSVLLYNLL", "length": 703 }, "evidence": [ { "id": "E1B735", "url": "https://omabrowser.org/oma/group/E1B735/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q95333-1", "protein_name": "Xaa-Pro aminopeptidase 2", "gene_name": "XPNPEP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQACWGCYPWLVLICACAWGHPKSLNQREDVRNCSTSPPYLPVTAVNTTAQLTALREQMLTQNLSAYIIPDTDAHMSEYIGECDQRRAWITGFIGSAGIAVVTERKAALWTDSRYWTQAERQMDCNWELHKEVSTGHIVTWLLTEIPVGGRVGFDPFLFSIDSWESYDVALQDADRELVSITVNLVDLVWGSERPPLPNAPIYALQEAFAGSTWQEKVSNIRSQMQKHHERPTAVLLSALDETAWLFNLRSSDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLQYLNSSCNSSMCVQLEDYSQIRDSIQAYTSGDVKIWIGTRYTSYGLYEVIPKEKLVEDDYSPVMITKAVKNSREQALLKASHVRDAVAVIRYLAWLEKNVPTGTVDEFSGAKRVEEFRGEEEFFSGPSFETISASGLNAALAHYSPTKELHRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLVFPAATSGRVVEAFARKALWDVGLNYGHGTGHGIGNFLCVHEWPVGFQYGNIPMAEGMFTSIEPGYYQDGEFGIRLEDVALVVEAKTKYPGTYLTFEVVSLVPYDRKLIDVSLLSPEQLQYLNRYYQAIREKVGPELQRRGLLEELSWLQRHTEPLSARAAPTTSLGSLMTVSALAILGWSV", "length": 673 }, "evidence": [ { "id": "E1B735", "url": "https://omabrowser.org/oma/group/E1B735/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q99MA2-1", "protein_name": "Xaa-Pro aminopeptidase 2", "gene_name": "Xpnpep2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQAYWQCYPWLVLLCACAWSYPGPESLGREDVRDCSTNPPRLPVTAVNTTMRLAALRQQMEKSNLSAYIIPDTDAHMSEYIGKHDERRAWISGFTGSAGTAVVTKKKAAVWTDSRYWTQAERQMDCNWELHKEVSISSIVAWILAEVPDGENVGFDPFLFSVGSWENYDQELQDSNRHLLSITTNLVDVAWGSERPPVPSQPIYALPKEFTGSTWQEKVSAIRSYMQNHTMAPTGVLLSALDETAWLFNLRSSDIPYNPFFYSYTLLTDSSIRLFVNKSRFSLETLQYLNTNCTLPMCVQLEDYSQIRDGVKAYASGNVKILIGISYTTYGVYDVIPKEKLVTETYSPVMLIKAVKNSKEQALLKASHVRDAVAVIQYLVWLEKNVPKGTVDEFSGAEHIDQLRRNENFSSGPSFETISASGLNAALAHYSPTKELHRKLSLDEMYLVDSGGQYWDGTTDITRTVHWGTPTAFQKEAYTRVLMGNIDLSRLVFPAATSGRVVEAFARRALWEVGLNYGHGTGHGIGNFLCVHEWPVGFQYNNMAMAKGMFTSIEPGYYQDGEFGIRLEDVALVVEAKTKYPGTYLTFELVSFVPYDRNLIDVSLLSPEQLQYLNRYYQTIRENIGPELQRRQLLEEFAWLERHTEPLSASAPHTTSLASMWVASALAILSWSC", "length": 674 }, "evidence": [ { "id": "E1B735", "url": "https://omabrowser.org/oma/group/E1B735/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "pmid": "" }, { "name": "metalloaminopeptidase activity", "id": "GO:0070006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070006", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "E1B735", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2197633" ], "enzyme_list": [ "F1MLP3-1", "A0A3Q1LSG5-1", "P09487-1", "E1B735-1", "A0AAA9S718-1", "F1MNM2-1", "F1MPH8-1", "A0A140T891-1", "A0A3Q1MCB1-1", "E1BJE3-1" ], "evidence": [ { "id": "R-BTA-8940388", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8940388" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2197633", "participant_name": "PI [extracellular region]", "crossref": [ { "id": "57880", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T891", "gene_name": "VNN1", "activity": [ { "ec_number": "3.5.1.92", "activity": "(R)-pantetheine + H2O = cysteamine + (R)-pantothenate.", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] }, { "ec_number": "3.5.1.92", "activity": "", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] } ] }, { "uniprot_ac": "A0A3Q1LSG5", "gene_name": "LOC100125266", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] } ] }, { "uniprot_ac": "A0A3Q1MCB1", "gene_name": "", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] } ] }, { "uniprot_ac": "A0AAA9S718", "gene_name": "SMCO3", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] } ] }, { "uniprot_ac": "E1B735", "gene_name": "XPNPEP2", "activity": [ { "ec_number": "3.4.11.9", "activity": "Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] }, { "ec_number": "3.4.11.9", "activity": "", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] } ] }, { "uniprot_ac": "E1BJE3", "gene_name": "LOC516378", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "E1BJE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE3" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "E1BJE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE3" } ] } ] }, { "uniprot_ac": "F1MLP3", "gene_name": "BST1", "activity": [ { "ec_number": "3.2.2.6", "activity": "NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+).", "evidence": [ { "id": "F1MLP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP3" } ] }, { "ec_number": "3.2.2.6", "activity": "", "evidence": [ { "id": "F1MLP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP3" } ] } ] }, { "uniprot_ac": "F1MNM2", "gene_name": "GPLD1", "activity": [ { "ec_number": "3.1.4.50", "activity": "[protein]-C-terminal carboxyl phosphoethanolamide-(1-radyl-2-octadecanoyl)-GPI(deacylinositol-H7) + H2O = [protein]-C-terminal carboxyl phosphoethanolamide-glycosylinositol (deacylinositol-H7) + 1-radyl-2-octadecanoyl-sn-glycero-3-phosphate + H(+).", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] }, { "ec_number": "3.1.4.50", "activity": "", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] } ] }, { "uniprot_ac": "F1MPH8", "gene_name": "LOC528262", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1MPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPH8" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F1MPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPH8" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B735-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 673, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B735-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B735" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" }, { "id": "PF01321", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01321" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Creatinase N-terminal", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 183, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" }, { "id": "PF00557", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00557" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M24", "eco_id": "ECO_0000259", "start_pos": 364, "end_pos": 574, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" }, { "id": "PF16188", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M24 C-terminal", "eco_id": "ECO_0000259", "start_pos": 584, "end_pos": 647, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.11.9", "ec_name": "Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.", "evidence": [ { "id": "3.4.11.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.11.9" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC95-1", "uniprot_ac": "E1BC95", "uniprot_id": "E1BC95_BOVIN", "mass": { "chemical_mass": 52846.0, "monoisotopic_mass": 52846.0 }, "refseq": {}, "gene_names": [ { "name": "BIVM", "type": "recommended", "evidence": [ { "id": "E1BC95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC95" } ] } ], "protein_names": [ { "name": "Basic immunoglobulin-like variable motif-containing protein", "type": "recommended", "evidence": [ { "id": "E1BC95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC95/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC95", "url": "https://www.uniprot.org/uniprotkb/E1BC95" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BIVM", "url": "https://www.uniprot.org/uniprotkb/E1BC95", "locus": { "chromosome": "12", "start_pos": 79076215, "end_pos": 79030045, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048674", "url": "https://www.ensembl.org/id/ENSBTAG00000048674" } ] } } ], "crossref": [ { "id": "E1BC95", "url": "https://alphafold.ebi.ac.uk/entry/E1BC95", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048674", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048674", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532455", "url": "https://www.ncbi.nlm.nih.gov/gene/532455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR060383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532455", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532455", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HCLMAFQ", "url": "https://omabrowser.org/oma/group/HCLMAFQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPG6", "url": "https://www.orthodb.org/?gene=A0A3Q1MPG6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16171:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16171:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MPG6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPG6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC95", "url": "https://www.uniprot.org/uniprotkb/E1BC95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC95-1", "url": "https://www.uniprot.org/uniprotkb/E1BC95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNVAEAEGADDSGNGEHKSERRSPEESLQGAVQSFCTRASGEPLGPRGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPNPARSCLSDSTSLSAANNSSRYIGISASTSDIIYNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNLKHKSGNGKKQVSKKKTSDKKGRHQREWPQYSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLVSCWNFLYSTMGAGKWFRQINDHFRVKGCSYVLYKPHGKNKTAGETASGALSKLTHGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAYSRGPLTPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRLSWQRFGLWNFPFGTIRQESQPPMHAHGIAKSESEDNISKKQHGRLGRSFSTGFHQDSTWKKMSSIHERRNSGYHGYSDYEGND", "length": 467, "header": "tr|E1BC95-1|E1BC95_BOVIN Isoform 1 of Basic immunoglobulin-like variable motif-containing protein OS=Bos taurus OX=9913 GN=BIVM PE=3 SV=3 CANONICAL=E1BC95-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPG6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPG6/entry", "sequence": { "sequence": "MPNVAEAEGADDSGNGEHKSERRSPEESLQGAVQSFCTRASGEPLGPRGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPNPARSCLSDSTSLSAANNSSRYIGISASTSDIIYNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNLKHKSGNGKKQVSKKKTSDKKGRHQREWPQYSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLVSCWNFLYSTMGAGNLPPITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFRVKGCSYVLYKPHGKNKTAGETASGALSKLTHGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAYSRGPLTPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRLSWQRFGLWNFPFGTIRQESQPPMHAHGIAKSESEDNISKKQHGRLGRSFSTGFHQDSTWKKMSSIHERRNSGYHGYSDYEGND", "length": 502, "header": "tr|A0A3Q1MPG6-1|E1BC95_BOVIN Computationally mapped isoform of Basic immunoglobulin-like variable motif-containing protein OS=Bos taurus OX=9913 GN=BIVM PE=3 SV=1 CANONICAL=E1BC95-1" }, "locus": { "chromosome": "12", "start_pos": 79074571, "end_pos": 79039893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084918.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084918.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073804.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073804.1" } ] } }, { "isoform_ac": "E1BC95-1", "url": "https://www.uniprot.org/uniprotkb/E1BC95/entry", "sequence": { "sequence": "MPNVAEAEGADDSGNGEHKSERRSPEESLQGAVQSFCTRASGEPLGPRGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPNPARSCLSDSTSLSAANNSSRYIGISASTSDIIYNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNLKHKSGNGKKQVSKKKTSDKKGRHQREWPQYSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLVSCWNFLYSTMGAGKWFRQINDHFRVKGCSYVLYKPHGKNKTAGETASGALSKLTHGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAYSRGPLTPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRLSWQRFGLWNFPFGTIRQESQPPMHAHGIAKSESEDNISKKQHGRLGRSFSTGFHQDSTWKKMSSIHERRNSGYHGYSDYEGND", "length": 467, "header": "tr|E1BC95-1|E1BC95_BOVIN Isoform 1 of Basic immunoglobulin-like variable motif-containing protein OS=Bos taurus OX=9913 GN=BIVM PE=3 SV=3 CANONICAL=E1BC95-1" }, "locus": { "chromosome": "12", "start_pos": 79074571, "end_pos": 79039893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061115.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061115.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053713.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053713.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532455", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532455", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AHA7-1", "protein_name": "Basic immunoglobulin-like variable motif-containing protein", "gene_name": "BIVM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPNVAEAERADASGNGECRSERRSPDENLQAATSSFCTRTPGEPLGPKGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPHSTRPSCLPDNTSLSAGNHSSRFVGSPTGTSEIIYKEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNLKHKSGNVKKQISKKKTSDKKGRHQREWPQYSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLISCWNFLYSTMGAGSLPAITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFHVKGCSYVLYKPHGKNKTAGETASGALSKLTHGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAFSRGPLSPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRLHWQRFGLWNFPFGTIRQESQPPPHAQGIAKSESEDNISKKQHGRLGRSFSASFHQDSTWKKMSSIHERRNSGYQGYSDYDGND", "length": 503 }, "evidence": [ { "id": "E1BC95", "url": "https://omabrowser.org/oma/group/E1BC95/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XU40-1", "protein_name": "Basic immunoglobulin-like variable motif-containing protein", "gene_name": "BIVM", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPHISEDEKENGSGNNGNTEKKPGKESSEASLRDPIKSYCISDASTVSLVSRGDGHYPWGCPVTHTREKFYTICSDYAFLNRVTSICKSPSASVNACLSGSAALNVGNNTPSLLGIQTGASEIIYSEDANLETLSGSLGKLPLAWEIDKSEFNSVTANHKNKAGNMKKQVAKKKSSDKKSKQYKECPQLSALEDVKERKVLDLRRWYCISRPQYKTSCGISSLVSCWNFLYSTLGAGSLPPITQEEALHILGFQPPFEEIRFGPFTGNTTLMRWFRQINDHFHIKGCSYVLYKPHGKNKTAGETAVGALAKLTRGLKDESMAYIYHCQNHYFCPIGFEATPVKASKAGRVLQQEVEYWILIGEPSRKHPTIHCKRWTDIVTDLNTQNPEYLDIRHLERGLQHRKTKKVGGNLHCIIAFQRLNWQRFGPWNIPFGSVRQDKQSQTQGQGIAKSESEDNISKKQHGRLGRSFSAGFHQESTWKKSSLRERRNSGYQSYNDYDGDD", "length": 503 }, "evidence": [ { "id": "E1BC95", "url": "https://omabrowser.org/oma/group/E1BC95/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A204-1", "protein_name": "Basic immunoglobulin-like variable motif-containing protein", "gene_name": "Bivm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPNITEAGKATDSGRDEYRSENKSPEENLQGALPSFYANASGTPVGPRGDGHYPSSCPVTHTREKVYAICSDYAFLNQATSVYKTPSPARSACLPDNTSLSAGNSTRYIGIPTSTSEIIYNEDNNLENLPTSMGKLPLAWEIDKSEFDGVTTNLKHKSGNAKKQISKKKTSDKKGRYQRECLHYSPLDDVKQRKVLDLRRWYCISRPQYKTSCGISSLISCWNFLYSIMGAGNLPPITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFHVKGCSYVLYKPHGKNKTAGETAPGALSKLTQGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAFSKGPLSPQEVEYWILIGESSRKHPAIHCKRWADIVTDLNTQNPEFLDIRHLERGLQFRKTKKVGGNLHCIIAFQRLSWQRFGFWNFPFGTITQESQPPTHVLGIAKSESEDNISKKQYGRLGRSFSASFHQDSAWKKVSGIHERRNSGYHSYRDYNGND", "length": 502 }, "evidence": [ { "id": "E1BC95", "url": "https://omabrowser.org/oma/group/E1BC95/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86UB2-1", "protein_name": "Basic immunoglobulin-like variable motif-containing protein", "gene_name": "BIVM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPNVAETERSNDSGNGEHKSERKSPEENLQGAVKSFCTSASGAPLGPKGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPNPSRSPCLPDSTSLSAGNNSSRYIGIPTSTSEIIYNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNSKHKSGNAKKQVSKRKTSDKKGRYQKECPQHSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLISCWNFLYSTMGAGNLPPITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFHVKGCSYVLYKPHGKNKTAGETASGALSKLTRGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAFSRGPLSPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRLNWQRFGLWNFPFGTIRQESQPPTHAQGIAKSESEDNISKKQHGRLGRSFSASFHQDSAWKKMSSIHERRNSGYQGYSDYDGND", "length": 503 }, "evidence": [ { "id": "E1BC95", "url": "https://omabrowser.org/oma/group/E1BC95/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CBX9-1", "protein_name": "Basic immunoglobulin-like variable motif-containing protein", "gene_name": "Bivm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPNATEAGKATDPGHGEHTSENKSPEEGLQGAVPSFYTSASEAPIAPRGDGHYPSSCPVTHTREKIYAICSDYAFLNQATSVYKTPSLTRSACLPDNTSLSAGNTTRYIGISTSTSEIIYNEENNLENLSTGMGKLPLAWEIDKSEFDGVTTNLIHKSGNVKKQFSKKKTSDKKGRHQRECLHYSPLDDVKQRKVLDLRRWYCISRPQYKTSCGISSLISCWNFLYSIMGAGNLPPITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFHVKGCSYVLYKPHGKNKTAGETAPGALSKLTRGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAFSRGPLSSQEVEYWILIGESSRKHPAIHCKRWADIVTDLNTQNPEFLDIRHLERGLQFRKTKKVGGNLHCIIAFQRLSWQRFGFWNFPFGTITQESQHPTHVPGIAKSESEDNISKKQHGRLGRSFSASFHQDSAWKNMSSIHERRNSGYHSFRDYNGND", "length": 502 }, "evidence": [ { "id": "E1BC95", "url": "https://omabrowser.org/oma/group/E1BC95/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BC95", "url": "https://www.uniprot.org/uniprotkb/E1BC95" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA endonuclease activity", "id": "GO:0004520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004520", "evidence": [ { "database": "UniProtKB", "id": "E1BC95", "url": "https://www.uniprot.org/uniprotkb/E1BC95" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "E1BC95", "url": "https://www.uniprot.org/uniprotkb/E1BC95" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 104, "end_pos": 106 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 258, "end_pos": 260 }, { "start_pos": 420, "end_pos": 422 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAY7-1", "uniprot_ac": "E1BAY7", "uniprot_id": "E1BAY7_BOVIN", "mass": { "chemical_mass": 210597.0, "monoisotopic_mass": 210597.0 }, "refseq": {}, "gene_names": [ { "name": "FER1L6", "type": "recommended", "evidence": [ { "id": "E1BAY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ] } ], "protein_names": [ { "name": "Fer-1-like protein 6", "type": "recommended", "evidence": [ { "id": "E1BAY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAY7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Calcium/phospholipid-binding protein which is essential for proper development of skeletal and cardiac muscle.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NDE6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDE6#function" }, { "database": "UniProtKB", "id": "ARBA00094315", "url": "https://www.uniprot.org/uniprotkb/ARBA00094315#function" }, { "database": "UniProtKB", "id": "A0A3Q1MUE1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE1#function" }, { "database": "UniProtKB", "id": "A0A3Q1N594", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N594#function" }, { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FER1L6", "url": "https://www.uniprot.org/uniprotkb/E1BAY7", "locus": { "chromosome": "14", "start_pos": 15864227, "end_pos": 16037622, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013537", "url": "https://www.ensembl.org/id/ENSBTAG00000013537" } ] } } ], "crossref": [ { "id": "ENSBTAG00000013537", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013537", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04011", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04011", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04017", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04017", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04018", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04018", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04037", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04037", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUE1", "url": "https://www.orthodb.org/?gene=A0A3Q1MUE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N594", "url": "https://www.orthodb.org/?gene=A0A3Q1N594", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NDE6", "url": "https://www.orthodb.org/?gene=A0A3Q1NDE6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAY7", "url": "https://www.orthodb.org/?gene=E1BAY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12546", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12546", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12546:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12546:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08150", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08150", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08151", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08151", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MUE1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUE1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N594", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N594", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N594-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N594-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NDE6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NDE6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKPSKAKKGMFGLKLKKKKNKAEKGLILANKGAQDDQAEAETPQEGPSHQEGLGGDLISDNTSITPVPSSPPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVIIEVGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQLHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDVLKPNPKTSDAEEQIEKNLLIPQGFPSERPWARFYVRLYKAEGLPKVNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTTVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDIVLATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQELNEGFGEGVSYRGRILVEIAVEILSGGSQESKFSKALKEFKLSPKDKDGKSSKGVSKDKGDKTDDGKPQQASDKTNSTEVEVEPFDVPPEIVPEKHEEFLLFGAFFEATMIDRRIGDKPISFEVSIGNFGNLIDGGLHHRSRKKSADSAEEDTLPLLHEGEGDAAHDAAIPLVSTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFVSSWGDQTFRLHWSNMLEKMADLLEEGIEEVKELIKISEEAPEEKMKMVLSDFISQSSAFISEAEKKPKMLNQTNLDKKRLTLCWQELEAIAKEAKGLTQQQKKKLSLEEMIQTAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPVRDQMGQHCGKIKTHFLKLPGKRPAGWSVQAKIDVYLWLGSTKHSSTILSNLPAGYEAEMSSKAAGIHHPPANLLYQDRHVFQLRAHVYQARGLIAADSNGLSDPFAKVTFLSHCQTTKVIPETLSPTWNQMLLFNDLVLHGDQKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPASGLQGLPPFDPPDVTQIYPVPASIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECAGRGVKSCVIQSYKNNPNFNVQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKSREPLSLTSQVGGAQVGKDISDSSVATEPSETLSSVQEEPKDHVFVDIEPPPTVVPDSAQVQAANLIDIPDSSPMLEPEHKPAAQEPPKDGKAKDSRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKEKESNSKEQKGNTEAKPDEVVVNIDSPKKKKDKILKKKPKEDEIPNLAVLQIYDGDLESEFNNFEDWVKTFDLLRGKSMEDDQGLDGDRVVGKFKGSFCIYKSLEDSSIEDSGQLRIQQGIPPNHPIKVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDLIGTDDLIGETRIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRPGEIQIGNQVFSGKTTFTKEDTDETVESYEHLALRVLHSWENIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPEDMPQPGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKREHIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLTKFENASEENMISIFQQKRVRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLDKPNRPNTSFSWFVSPFKCLYHLIWRNYKKYIIIGFILIILIIFLVLFIYTLPGAISQRIVGGS", "length": 1869, "header": "tr|E1BAY7-1|E1BAY7_BOVIN Isoform 1 of Fer-1-like protein 6 OS=Bos taurus OX=9913 GN=FER1L6 PE=3 SV=4 CANONICAL=E1BAY7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUE1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE1/entry", "sequence": { "sequence": "MEKPSKAKKGMFGLKLKKKKNKAEKGLILANKGAQDDQAEAETPQEGPSHQEGLGGDLISDNTSITPVPSSPPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVIIEVGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQLHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDVLKPNPKTSDAEEQIEKNLLIPQGFPSERPWARFYVRLYKAEGLPKVNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTTVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDIVLATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQELNEGFGEGVSYRGRILVEIAVEILSGGSQESKFSKALKEFKLSPKDKDGKSSKGVSKDKGDKTDDGKPQQASDKTNSTEVEVEPFDVPPEIVPEKHEEFLLFGAFFEATMIDRRIGDKPISFEVSIGNFGNLIDGGLHHRSRKKSADSAEEDTLPLLHEGEGDAAHDAAIPLVSTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFVSSWGDQTFRLHWSNMLEKMADLLEAIAKEAKGLTQQQKKKLSLEEMIQTAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPVRDQMGQHCGKIKTHFLKLPGKRPAGWSVQAKIDVYLWLGSTKHSSTILSNLPAGYEAEMSSKAAGIHHPPANLLYQDRHVFQLRAHVYQARGLIAADSNGLSDPFAKVTFLSHCQTTKVIPETLSPTWNQMLLFNDLVLHGDQKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPASGLQGLPPFDPPDVTQIYPVPASIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECAGRGVKSCVIQSYKNNPNFNVQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKSREPLSLTSQVGGAQVGKDISDSSVATEPSETLSSVQEEPKDHVFVDIEPPPTVVPDSAQVQAANLIDIPDSSPMLEPEHKPAAQEPPKDGKAKDSRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKEKESNSKEQKGNTEAKPDEVVVNIDSPKKKKDKILKKKPKEDEIPNLAVLQIYDGDLESEFNNFEDWVKTFDLLRGKSMEDDQGLDGDRVVGKFKGSFCIYKSLEDSSIEDSGQLRIQQGIPPNHPIKVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDLIGTDDLIGETRIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRPGEIQIGNQVFSGKTTFTKEDTDETVESYEHLALRVLHSWENIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPEDMPQPGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKREHIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLTKFENASEENMISIFQQKRVRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLDKPNRPNTSFSWFVSPFKCLYHLIWRNYKKYIIIGFILIILIIFLVLFIYTLPGAISQRIVGGS", "length": 1805, "header": "tr|A0A3Q1MUE1-1|E1BAY7_BOVIN Computationally mapped isoform of Fer-1-like protein 6 OS=Bos taurus OX=9913 GN=FER1L6 PE=3 SV=2 CANONICAL=E1BAY7-1" }, "locus": { "chromosome": "14", "start_pos": 16037505, "end_pos": 15865231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082202.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082202.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058468.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058468.2" } ] } }, { "isoform_ac": "A0A3Q1N594-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N594/entry", "sequence": { "sequence": "MLSLFGLRYRSHGSFHPEETRKGMFGLKLKKKKNKAEKGLILANKGAQDDQAEAETPQEGPSHQEGLGGDLISDNTSITPVPSSPPKRRNDNSSRRQNQELSLTCSIAITITEARQLVGENIDPVVIIEVGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQLHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDVLKPNPKTSDAEEQIEKNLLIPQGFPSERPWARFYVRLYKAEGLPKVNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTTVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDIVLATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQELNEGFGEGVSYRGRILVEIAVEILSGGSQESKFSKALKEFKLSPKDKDGKSSKGVSKDKGDKTDDGKPQQASDKTNSTEVEVEPFDVPPEIVPEKHEEFLLFGAFFEATMIDRRIGDKPISFEVSIGNFGNLIDGGLHHRSRKKSADSAEEDTLPLLHEGEGDAAHDAAIPLVSTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFVSSWGDQTFRLHWSNMLEKMADLLEEGIEEVKELIKISEEAPEEKMKMVLSDFISQSSAFISEAEKKPKMLNQTNLDKKRLTLCWQELEAIAKEAKGLTQQQKKKLSLEEMIQTAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPVRDQMGQHCGKIKTHFLKLPGKRPAGWSVQAKIDVYLWLGSTKHSSTILSNLPAGYEAEMSSKAAGIHHPPANLLYQDRHVFQLRAHVYQARGLIAADSNGLSDPFAKVTFLSHCQTTKVIPETLSPTWNQMLLFNDLVLHGDQKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPASGLQGLPPFDPPDVTQIYPVPASIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECAGRGVKSCVIQSYKNNPNFNVQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKSREPLSLTSQVGGAQVGKDISDSSVATEPSETLSSVQEEPKDHVFVDIEPPPTVVPDSAQVQAANLIDIPDSSPMLEPEHKPAAQEPPKDGKAKDSRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKEKESNSKEQKGNTEAKPDEVVVNIDSPKKKKDKILKKKPKEDEIPNLAVLQIYDGDLESEFNNFEDWVKTFDLLRGKSMEDDQGLDGDRVVGKFKGSFCIYKSLEDSSIEDSGQLRIQQGIPPNHPIKVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDLIGTDDLIGETRIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRPGEIQIGNQVFSGKTTFTKEDTDETVESYEHLALRVLHSWENIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPEDMPQPGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKREHIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLTKFENASEENMISIFQQKRVRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLDKPNRPNTSFSWFVSPFKCLYHLIWRNYKKYIIIGFILIILIIFLVLFIYTLPGAISQRIVGGS", "length": 1881, "header": "tr|A0A3Q1N594-1|E1BAY7_BOVIN Computationally mapped isoform of Fer-1-like protein 6 OS=Bos taurus OX=9913 GN=FER1L6 PE=3 SV=2 CANONICAL=E1BAY7-1" }, "locus": { "chromosome": "14", "start_pos": 16000277, "end_pos": 15865231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072924.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072924.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065282.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065282.2" } ] } }, { "isoform_ac": "A0A3Q1NDE6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDE6/entry", "sequence": { "sequence": "MEKPSKAKYRSHGSFHPEETRKGMFGLKLKKKKNKAEKGLILANKGAQDDQAEAETPQEGPSHQEGLGGDLISDNTSITPVPSSPPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVIIEVGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQLHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDVLKPNPKTSDAEEQIEKNLLIPQGFPSERPWARFYVRLYKAEGLPKVNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTTVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDIVLATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQELNEGFGEGVSYRGRILVEIAVEILSGGSQESKFSKALKEFKLSPKDKDGKSSKGVSKDKGDKTDDGKPQQASDKTNSTEVEVEPFDVPPEIVPEKHEEFLLFGAFFEATMIDRRIGDKPISFEVSIGNFGNLIDGGLHHRSRKKSADSAEEDTLPLLHEGEGDAAHDAAIPLVSTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFVSSWGDQTFRLHWSNMLEKMADLLEEGIEEVKELIKISEEAPEEKMKMVLSDFISQSSAFISEAEKKPKMLNQTNLDKKRLTLCWQELEAIAKEAKGLTQQQKKKLSLEEMIQTAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPVRDQMGQHCGKIKTHFLKLPGKRPAGWSVQAKIDVYLWLGSTKHSSTILSNLPAGYEAEMSSKAAGIHHPPANLLYQDRHVFQLRAHVYQARGLIAADSNGLSDPFAKVTFLSHCQTTKVIPETLSPTWNQMLLFNDLVLHGDQKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPASGLQGLPPFDPPDVTQIYPVPASIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECAGRGVKSCVIQSYKNNPNFNVQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKSREPLSLTSQVGGAQVGKDISDSSVATEPSETLSSVQEEPKDHVFVDIEPPPTVVPDSAQVQAANLIDIPDSSPMLEPEHKPAAQEPPKDGKAKDSRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKEKESNSKEQKGNTEAKPDEVVVNIDSPKKKKDKILKKKPKEDEIPNLAVLQIYDGDLESEFNNFEDWVKTFDLLRGKSMEDDQGLDGDRVVGKFKGSFCIYKSLEDSSIEDSGQLRIQQGIPPNHPIKVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDLIGTDDLIGETRIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRPGEIQIGNQVFSGKTTFTKEDTDETVESYEHLALRVLHSWENIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPEDMPQPGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKREHIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLTKFENASEENMISIFQQKRVRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLDKPNRPNTSFSWFVSPFKCLYHLIWRNYKKYIIIGFILIILIIFLVLFIYTLPGAISQRIVGGS", "length": 1882, "header": "tr|A0A3Q1NDE6-1|E1BAY7_BOVIN Computationally mapped isoform of Fer-1-like protein 6 OS=Bos taurus OX=9913 GN=FER1L6 PE=3 SV=2 CANONICAL=E1BAY7-1" }, "locus": { "chromosome": "14", "start_pos": 16037505, "end_pos": 15865231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069510.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069510.2" } ] } }, { "isoform_ac": "E1BAY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAY7/entry", "sequence": { "sequence": "MEKPSKAKKGMFGLKLKKKKNKAEKGLILANKGAQDDQAEAETPQEGPSHQEGLGGDLISDNTSITPVPSSPPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVIIEVGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQLHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCDKWALLTDPGDIRTGTKGYLKCDISVTGKGDVLKPNPKTSDAEEQIEKNLLIPQGFPSERPWARFYVRLYKAEGLPKVNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQTGRTTVQKNCADPVWHEQVVFKEMFPPLCRRVKIQVWDEGSMNDIVLATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQELNEGFGEGVSYRGRILVEIAVEILSGGSQESKFSKALKEFKLSPKDKDGKSSKGVSKDKGDKTDDGKPQQASDKTNSTEVEVEPFDVPPEIVPEKHEEFLLFGAFFEATMIDRRIGDKPISFEVSIGNFGNLIDGGLHHRSRKKSADSAEEDTLPLLHEGEGDAAHDAAIPLVSTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFVSSWGDQTFRLHWSNMLEKMADLLEEGIEEVKELIKISEEAPEEKMKMVLSDFISQSSAFISEAEKKPKMLNQTNLDKKRLTLCWQELEAIAKEAKGLTQQQKKKLSLEEMIQTAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNKRVAYARIAAKDLLYSPVRDQMGQHCGKIKTHFLKLPGKRPAGWSVQAKIDVYLWLGSTKHSSTILSNLPAGYEAEMSSKAAGIHHPPANLLYQDRHVFQLRAHVYQARGLIAADSNGLSDPFAKVTFLSHCQTTKVIPETLSPTWNQMLLFNDLVLHGDQKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPASGLQGLPPFDPPDVTQIYPVPASIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQVLIECAGRGVKSCVIQSYKNNPNFNVQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKSREPLSLTSQVGGAQVGKDISDSSVATEPSETLSSVQEEPKDHVFVDIEPPPTVVPDSAQVQAANLIDIPDSSPMLEPEHKPAAQEPPKDGKAKDSRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKEKESNSKEQKGNTEAKPDEVVVNIDSPKKKKDKILKKKPKEDEIPNLAVLQIYDGDLESEFNNFEDWVKTFDLLRGKSMEDDQGLDGDRVVGKFKGSFCIYKSLEDSSIEDSGQLRIQQGIPPNHPIKVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSVLIYDHDLIGTDDLIGETRIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFRPGEIQIGNQVFSGKTTFTKEDTDETVESYEHLALRVLHSWENIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPEDMPQPGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKREHIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKSAKACDLTKFENASEENMISIFQQKRVRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLDKPNRPNTSFSWFVSPFKCLYHLIWRNYKKYIIIGFILIILIIFLVLFIYTLPGAISQRIVGGS", "length": 1869, "header": "tr|E1BAY7-1|E1BAY7_BOVIN Isoform 1 of Fer-1-like protein 6 OS=Bos taurus OX=9913 GN=FER1L6 PE=3 SV=4 CANONICAL=E1BAY7-1" }, "locus": { "chromosome": "14", "start_pos": 16037505, "end_pos": 15865231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025707.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025707.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025707.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025707.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "plasma membrane organization", "id": "GO:0007009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007009", "evidence": [ { "database": "UniProtKB", "id": "E1BAY7", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1379, "end_pos": 1381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1747, "end_pos": 1749, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1812, "end_pos": 1814, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 668, "end_pos": 670, "annotation": "n_glycosylation_sequon" }, { "start_pos": 957, "end_pos": 959, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAY7" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 194, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1379, "end_pos": 1381 }, { "start_pos": 1747, "end_pos": 1749 }, { "start_pos": 1812, "end_pos": 1814 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 468, "end_pos": 470 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 668, "end_pos": 670 }, { "start_pos": 957, "end_pos": 959 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7Q4-1", "uniprot_ac": "E1B7Q4", "uniprot_id": "E1B7Q4_BOVIN", "mass": { "chemical_mass": 151777.0, "monoisotopic_mass": 151777.0 }, "refseq": { "ac": "NP_001192956", "name": "WD repeat-containing protein 19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192956" }, "gene_names": [ { "name": "WDR19", "type": "recommended", "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ] }, { "name": "WDR19", "type": "synonym", "evidence": [ { "id": "NP_001192956", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192956" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 19", "type": "recommended", "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4/entry#names_and_taxonomy" } ] }, { "name": "Intraflagellar transport 144 homolog", "type": "synonym", "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 19", "type": "synonym", "evidence": [ { "id": "NP_001192956", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192956" } ] } ], "function": [ { "annotation": "As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport.", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4#function" }, { "database": "UniProtKB", "id": "ARBA00053638", "url": "https://www.uniprot.org/uniprotkb/ARBA00053638#function" }, { "database": "UniProtKB", "id": "A0A3Q1MXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD0#function" } ] }, { "annotation": "Report provides evidence that naturally occurring variation, a synonymous variant (BTA6:58373887C>T, rs474302732) in WDR19 is associated with reduced semen quality and fertility. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001192956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192956" }, { "database": "PubMed", "id": "32407316", "url": "https://glygen.org/publication/PubMed/32407316" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR19", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4", "locus": { "chromosome": "6", "start_pos": 58428624, "end_pos": 58350006, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014512", "url": "https://www.ensembl.org/id/ENSBTAG00000014512" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014512", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014512", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533633", "url": "https://www.ncbi.nlm.nih.gov/gene/533633", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533633", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533633", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NDMLTHT", "url": "https://omabrowser.org/oma/group/NDMLTHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MXD0", "url": "https://www.orthodb.org/?gene=A0A3Q1MXD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7Q4", "url": "https://www.orthodb.org/?gene=E1B7Q4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14920:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14920:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15911", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15911", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5610787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192956", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRVFSLLEKTWLGTPIQFTWQKTSGNYLAVTGADHIVKIFDRHGQKRSEINLSGNCVTMDWDKDGDILAVIAEKSSCIYLWDANTNKTSQLDSGLRDQLSFLLWSKFGSFLAVGTVKGNLLIYNHQTSRKIPVIGKHTKKITCGCWNAENMLALGGEDKMITVSNQEGDTIRQIPVRSEPSDMQFSMMKTDDRTSTAESTISVVVGKKTLFLFNLNEPDNPIDLEFQQHYGNIVCYSWYGDGYIMIGFSRGTFVVISTHIREIGQEIFQARDHKDSLTSIAVSQTLNKAATCGDNCIKIHDLAELKDMYAIVNLDDEHKGLSTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDVEYLGTVASVCLYSDYASALFEGKVQLHLIESEMLDTQEERETRLFPAVDDKCRILCHALTGDFLIYGTDTGVIQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGYVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGSKVILAGGTKVPFSHKPLLLYNGELTCQTQSGKINNIYLSTHRFLDTLKDVGPHELRQVLTQTLMLKRFPDAWELCKILNDQAAWNELARACLHHMEVEFAIRVYRTIGNVGMVMSLEQIKGIEDYNLLAGHLAMFSDDFNLAQDLYLASSCPVAALEMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYANALAHYEKGITGDNKEHDEVCLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVSIVRETQSLEGAKLVARFFLQLGDYGSAIQFLVISKCNNEAFTLAQQHNKMEIYADIIGSENTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYSRALKHFLKCPSSEDNAAIEMAIETVGQAKDELLTSQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVRIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFGFAAMLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCEFLLPECELLCPGCKNNIPYCIATGRHMLKDDWAVCPHCDFPALYSEFKVMLSTESTCPMCSERLNLDQLKKTSDCTQYLRTEVEQ", "length": 1342, "header": "tr|E1B7Q4-1|E1B7Q4_BOVIN Isoform 1 of WD repeat-containing protein 19 OS=Bos taurus OX=9913 GN=WDR19 PE=4 SV=3 CANONICAL=E1B7Q4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD0/entry", "sequence": { "sequence": "MKRVFSLLEKTWLGTPIQFTWQKTSGNYLAVTGADHIVKIFDRHGQKRSEINLSGNCVTMDWDKDGDILAVIAEKSSCIYLWDANTNKTSQLDSGLRDQLSFLLWSKFGSFLAVGTVKGNLLIYNHQTSRKIPVIGKHTKKITCGCWNAENMLALGGEDKMITVSNQEGDTIRQIPVRSEPSDMQFSMMKTDDRTSTAESTISVVVGKKTLFLFNLNEPDNPIDLEFQQHYGNIVCYSWYGDGYIMIGFSRGTFVVISTHIREIGQEIFQARDHKDSLTSIAVSQTLNKAATCGDNCIKIHDLAELKDMYAIVNLDDEHKGLSTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDVEYLGTVASVCLYSDYASALFEGKVQLHLTGVIQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGYVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGSKVILAGGTKVPFSHKPLLLYNGELTCQTQSGKINNIYLSTHRFLDTLKDVGPHELRQVLTQTLMLKRFPDAWELCKILNDQAAWNELARACLHHMEVEFAIRVYRTIGNVGMVMSLEQIKGIEDYNLLAGHLAMFSDDFNLAQDLYLASSCPVAALEMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYANALAHYEKGITGDNKEHDEVCLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVSIVRETQSLEGAKLVARFFLQLGDYGSAIQFLVISKCNNEAFTLAQQHNKMEIYADIIGSENTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYSRALKHFLKCPSSEDNAAIEMAIETVGQAKDELLTSQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVRIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFGFAAMLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCEFLLPECELLCPGCKNNIPYCIATGRHMLKDDWAVCPHCDFPALYSEFKVMLSTESTCPMCSERLNLDQLKKTSDCTQYLRTEVEQ", "length": 1301, "header": "tr|A0A3Q1MXD0-1|E1B7Q4_BOVIN Computationally mapped isoform of WD repeat-containing protein 19 OS=Bos taurus OX=9913 GN=WDR19 PE=4 SV=2 CANONICAL=E1B7Q4-1" }, "locus": { "chromosome": "6", "start_pos": 58422158, "end_pos": 58350077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069073.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069073.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060351.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060351.2" } ] } }, { "isoform_ac": "A0AAA9SHW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHW9/entry", "sequence": { "sequence": "MKRVFSLLEKTWLGTPIQFTWQKTSGNYLAVTGADHIVKIFDRHGQKRSEINLSGNCVTMDWDKDGDILAVIAEKSSCIYLWDANTNKTSQLDSGLRDQLSFLLWSKFGSFLAVGTVKGNLLIYNHQTSRKIPVIGKHTKKITCGCWNAENMLALGGEDKMITVSNQEGDTIRQIPVRSEPSDMQFSMMKTDDRTSTAESTISVVVGKKTLFLFNLNEPDNPIDLEFQQHYGNIVCYSWYGDGYIMIGFSRGTFVVISTHIREIGQEIFQARDHKDSLTSIAVSQTLNKAATCGDNCIKIHDLAELKDMYAIVNLDDEHKGLSTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDVEYLGTVASVCLYSDYASALFEGKVQLHLIESEMLDTQEERETRLFPAVDDKCRILCHALTGDFLIYGTDTGVIQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGYVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGSKVILAGGTKVPFSHKPLLLYNGELTCQTQSGKINNIYLSTHRFLDTLKDVGPHELRQVLTQTLMLKRFPDAWELCKILNDQAAWNELARACLHHMEVEFAIRVYRTIGNVGMVMSLEQIKGIEDYNLLAGHLAMFSDDFNLAQDLYLASSCPVAALESLQSCPSLCDPLDCTCQAPLSMGFSRQEYWSGLSCPPAGDLPDPGVEPTSLMHLNATHLHWQMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYANALAHYEKGITGDNKEHDEVCLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVSIVRETQSLEGAKLVARFFLQLGDYGSAIQFLVISKCNNEAFTLAQQHNKMEIYADIIGSENTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYSRALKHFLKCPSSEDNAAIEMAIETVGQAKDELLTSQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVRIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFGFAAMLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCEFLLPECELLCPGCKNNIPYCIATGRHMLKDDWAVCPHCDFPALYSEFKVMLSTESTCPMCSERLNLDQLKKTSDCTQYLRTEVEQ", "length": 1404, "header": "tr|A0AAA9SHW9-1|E1B7Q4_BOVIN Computationally mapped isoform of WD repeat-containing protein 19 OS=Bos taurus OX=9913 GN=WDR19 PE=4 SV=1 CANONICAL=E1B7Q4-1" }, "locus": { "chromosome": "6", "start_pos": 58422158, "end_pos": 58350077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135777.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135777.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083341.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083341.1" } ] } }, { "isoform_ac": "E1B7Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4/entry", "sequence": { "sequence": "MKRVFSLLEKTWLGTPIQFTWQKTSGNYLAVTGADHIVKIFDRHGQKRSEINLSGNCVTMDWDKDGDILAVIAEKSSCIYLWDANTNKTSQLDSGLRDQLSFLLWSKFGSFLAVGTVKGNLLIYNHQTSRKIPVIGKHTKKITCGCWNAENMLALGGEDKMITVSNQEGDTIRQIPVRSEPSDMQFSMMKTDDRTSTAESTISVVVGKKTLFLFNLNEPDNPIDLEFQQHYGNIVCYSWYGDGYIMIGFSRGTFVVISTHIREIGQEIFQARDHKDSLTSIAVSQTLNKAATCGDNCIKIHDLAELKDMYAIVNLDDEHKGLSTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDVEYLGTVASVCLYSDYASALFEGKVQLHLIESEMLDTQEERETRLFPAVDDKCRILCHALTGDFLIYGTDTGVIQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGYVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGSKVILAGGTKVPFSHKPLLLYNGELTCQTQSGKINNIYLSTHRFLDTLKDVGPHELRQVLTQTLMLKRFPDAWELCKILNDQAAWNELARACLHHMEVEFAIRVYRTIGNVGMVMSLEQIKGIEDYNLLAGHLAMFSDDFNLAQDLYLASSCPVAALEMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYANALAHYEKGITGDNKEHDEVCLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVSIVRETQSLEGAKLVARFFLQLGDYGSAIQFLVISKCNNEAFTLAQQHNKMEIYADIIGSENTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYSRALKHFLKCPSSEDNAAIEMAIETVGQAKDELLTSQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVRIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFGFAAMLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCEFLLPECELLCPGCKNNIPYCIATGRHMLKDDWAVCPHCDFPALYSEFKVMLSTESTCPMCSERLNLDQLKKTSDCTQYLRTEVEQ", "length": 1342, "header": "tr|E1B7Q4-1|E1B7Q4_BOVIN Isoform 1 of WD repeat-containing protein 19 OS=Bos taurus OX=9913 GN=WDR19 PE=4 SV=3 CANONICAL=E1B7Q4-1" }, "locus": { "chromosome": "6", "start_pos": 58422158, "end_pos": 58350077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019294.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019294.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019294.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019294.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility.", "journal": "PLoS genetics", "date": "2020-05", "authors": "Hiltpold Maya, Niu Guanglin, Kadri Naveen Kumar, Crysnanto Danang, Fang Zih-Hua, Spengeler Mirjam, Schmitz-Hsu Fritz, Fuerst Christian, Schwarzenbacher Hermann, Seefried Franz R, Seehusen Frauke, Witschi Ulrich, Schnieke Angelika, Fries Ruedi, Bollwein Heinrich, Flisikowski Krzysztof, Pausch Hubert", "evidence": [ { "database": "RefSeq", "id": "NP_001192956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192956" } ], "reference": [ { "type": "PubMed", "id": "32407316", "url": "https://glygen.org/publication/PubMed/32407316" } ] } ], "pathway": [ { "id": "bta:533633", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533633", "resource": "KEGG Pathway" }, { "id": "R-BTA-5610787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "resource": "Reactome", "description": "Hedgehog 'off' state" }, { "id": "R-BTA-5620924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "resource": "Reactome", "description": "Intraflagellar transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A1ZBM3-1", "protein_name": "Outer segment 6", "gene_name": "Oseg6", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSFEKILYKYEEPHGIGDVYFIWQKALLATTGTDGSVALYNRQGQLVQRIILSGLCSGFAWDQEGDLLGIITSGSPNITLWDYNSQEKISVETGLRDPLTCILWSKQQQLLAVGTGRGNLAIYNHSSGKRPTPVLGKHSKRITCGAWSAQNLLALGSEDKSFSLSNEDGDTVRVVQLRDAPTDMYFAEMANDERIAGDNAISMIIGKRTLFLYYLPEPENPTELGFQSRYGSLMQHKWFGDGYILLGFSNGHVVAISTHPKDVGQELWQVKNHKDSLTGLAYCPTLDIVASCGDDSIKIHSITNLQETERIITVPDHAGVQMIDWSPDGQLLAVTTNHGTVYIYVTKLPHLFAVSAPRIVLLSSLAEVSIYVYAPDKTKSLPFRLPLEGEPTFMAVGPYNFATGIEKHVWFYDLGKSLGEEPRPLSERDFPRSVESMKLNADYCAALCPPQLILQAIAADNPNCKDKLQAVFPTALPNMPSDAVITCFALSQELLIFATDIGHLVFYSLEKWDSCTIYRHSMGIRQLFMDIEGTKVIFIDDHSQGYVFLPVVEEALLIPDIPKQCLGCLWDLTQPNIFISYDARIVNTHVFVRHSVQGTHTLMVGESKLNPGQFPLLLCGGEMALHIDGGQYATQSLSTHVVNPSNSQAANLQMLLKLRNYDEAYKLCKQMNQSSAWREFGEQAISDLEPDIAIRAYRQLGDAALVNALSELRYVEDLDMLIGCCCTLLAQYDQAKEHMLKGVYTRAALDLCRDLLQWDQALLLAHKNDPQEVPYIAREYAQQLEFNGNYTDALYHYEKGYKEDLINSKETETDALMDSSPEYEEHVRLCKMGIARTSIRAGDFRRGIQYAVELEDQQLLFDCAELLATVGHLTEAAGLYERGGFYDEACGHYIALKMWNKANNILPKVKSTKLHAAYAKAKENDGHYEEAIRSYRIAGDLDACVRIYLDHLCDPHAASEIVLESRSMDSAKLLAKFYQKIGDVEQALQFLVICGCVEEAFALAQRHNKLRRHGELLERYENAKSSDYLALAHYFEGEKYTLLAGKYYFLAREFTKALRFLLKASAFNNEEQVSLSLAIDCVATSNNEQLATQLIEFLLGEVDGVPKDPRYLFRLYMARKHYKDAAKTAVIIANQEQIAGNYKSARDLLYSMYQELRRNNLSVTAEMRHQFILLHRYTLVRIHVKLGNHLLAAKLLVQVAACISQFPEHIIPILTSTVIECHRAGLKKSAFTYASTLMRPDYRNQLDPRYAKKIESIVRKAPKGIKQLRDEIDGETMECPICDSNLANMEVTCYSCKTTLPICIATGQHIIKQLMTSCPQCDFLCFRAEMENILSENGECPMCGENVAPEQLLDVEDIRPYILAAS", "length": 1366 }, "evidence": [ { "id": "E1B7Q4", "url": "https://omabrowser.org/oma/group/E1B7Q4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1LV01-1", "protein_name": "WD repeat-containing protein 19", "gene_name": "Wdr19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKRVFSLLEKTWLGAPIQFAWQKSSGNYLAVTGADSVVKIFDRHGQKRSEISLPGNCVAMDWDKDGDILAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKIGSFLAVGTIKGNLLIYNHQTSRKIPVLGKHTKKITCGCWNTENLLALGGEDRMITVSNQEGDTIRQTPVKSEPSDIKFSTSKTDERISSAESTISAVVGKKMLFLFHLNEPDNPVDLEFQQAYGNIVCYSWYGDGYIMIGFSRGTFLAISTHFPEVGQEIFKTRDHKDNLTSVALSQTLNKAATCGDNCIKIHDLTELRDMYAIINLDDENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACHTRIAYLTSLLEVTVANLIEGEPPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENVVKKLKDVEYLGTVASICLHSDYAAALFEGKIQLHLIENEMLDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGIIQYFFIEDWQFVNDYRHPVGVKKLFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGSKVILAGGTKLPFSHKPLLLYNGELTCQTQSGKINSIYLSTHSFLDSVKDTEPPDLRQMLMQTLMLKRFPDAWDICKMLNDRTSWSELARACLHHMEVEFAIRVSRTMGDVGTVMSLEQIKGIEDYNLLAGHLAMFTNDFNLAQDLYLASNCPVAALEMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYVNALAHYEKGITGDNKEHDEVCLAGVAQMSIRMGDIRRGANQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGQYYDRAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVSIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVLSKCNNEAFTLAQQHNKMEIYADIIGAEDTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVKIHVKSGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFSFAAMLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCQFLLPECELLCPGCKNNIPYCIATGRHMLKDDWTMCPHCGFPALYSEFKILLNSESTCPMCSERLNSSQLKKITDCTQYLRTETE", "length": 1341 }, "evidence": [ { "id": "E1B7Q4", "url": "https://omabrowser.org/oma/group/E1B7Q4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LLZ8-1", "protein_name": "WD repeat-containing protein 19", "gene_name": "WDR19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKRVFTLLEKTWLGTPIWFTWQKTSGNYLAVTGADHIVKIFDRHGQQRSEINLSGNCVAMDWDKDGDILAVIAEKSSYIYLWDANTNKTSQLDSGMRDQMSFLLWSKFGSFLAVGTVKGNLLIYNRQTSRKIPVLGKHTKRITCGCWNAENMLALGGEDKMITVSNQEGDTIRQTPVRSEPSDMQFSMMKTDDRTSAAESTISVVVGKKTLFLFNLSEPDNPIDLEFQQQYGNIVCYSWYGDGYIMIGFSRGIFVVISTHVREIGQEIFQARDHKDSLTSIAVSQTLNKAATCGDNCIKIHDLADLKDMYAIINLDDENKGLGTLSWTEDGQLLALSTQSGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPVTVSVHVEPNFVAVGLYHLAVGMNNRAWFYVLEENAVKKLKDMEYLGTVASICLHSDYAAALFEGKVQLHLIESEVLDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGVIQYFYIEDWQFVNDYRHPVGVKKIFPDPNGTRLVFIDEKSEGFVYCPVKDATYEIPDFPPTIKGVLWENWPVDKGVFIAYDDDKVYTYVFHKDTIQGSKVILAGGTKVPFSHKPLLLYNGELTCQTQSGKINNIYLSTHSFLESLKDMGTNERRQMLTQTLMLKRFPDAWEVCKILNDHAAWNELARACLYHMEVEFAIRVYRTIGNVGMVMSLEQIKGIEDCHLLAGHLAMFTSDFNLAQDLYLASSCPVAALEMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYVNALAHYEKGITGDNKEHDEVCLAGIAQMSIRMGDIRRGVSQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRCKNWAKVGELLPHVSSPKIHLQFAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVRIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYVDVIGSGDTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYARALKHFLKCPNSEDNAALEMAIETVGQAKDDVLTSQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKAQKIKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFSFAATLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCEFLLPECELLCPGCKNNIPYCIATGRHMLKDDWTVCPHCDFPALYSEFKRMLNTERTCPMCSERLNLAQLKKISDYTQYLQTEVEQ", "length": 1342 }, "evidence": [ { "id": "E1B7Q4", "url": "https://omabrowser.org/oma/group/E1B7Q4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UGF1-1", "protein_name": "WD repeat-containing protein 19", "gene_name": "Wdr19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRVFSLLEKSWLGAPIQFAWQKSSGNYLAVTGADYIVKIFDRHGQKRSEISLPGNCVTMDWDKDGDILAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKIGSFLAVGTIKGNLLIYNHQTSRKIPVLGKHTKKITCGCWNSENLLALGGEDKMITVSNQEGDTIRQTPVKSEPSDIKFSMSKTDERISSAENTISAVVGKKMLFLFHLNEPDNPVDLEFQQAYGNIVCYSWYGDGYIMIGFSRGTFLAISTHFPEVGQEIFKARDHKDNLTSVALSQTLNKAATCGDNCIKIHDLTELRDMYAIINLDDENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACHTRIAYLTSLLEVTVANLIEGEPPITVSVDVEPTFVAVGLYHLAVGMNNRAWFYVLGENVVKKLKDVEYLGTVASICLHSDYAAALFEGKIQLHLIENEMLDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGIIHYFFIEDWQFVNDYRHPVGVKKLFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYAFHKDTIQGSKVILAGSTKLPFSHKPLLLYNGELTCQTQSGKINSIYLSTHSFLGSMKDTEPTDLRQMLTQTLLLKRFSDAWDICKMLNDRTSWSELAKACLHHMEVEFAIRVSRTMGDVGTVMSLEQIKGIEDYNLLAGHLAMFTNDFNLAQDLYLASNCPVAALEMRRDLQHWDSALQLAKRLAPDQIPFISKEYAIQLEFTGDYVNALAHYEKGITGDNKEHDEVCLAGVAQMSIRMGDIRRGANQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGQYYDRAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWNSVIRIYLDHLNNPEKAVSIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVLSKCNNEAFTLAQQHNKMEIYADIIGAEDTTNEDYQSIALYFEGEKRHFQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLMGESDGMPKDAKYLFRLYMALKQYREAARTAIIIAREEQSAGNYRNAHDVLFSMYAELKAQKIKIPSEMATNLMILHSYILVKIHVKSGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFSFAAMLMRPEYRNKIDAKYKKKIEAMVRRPDTSETEEATTPCPFCQFLLPECELLCPGCKNNIPYCIATGRHMLKDDWTMCPHCGFPALYSEFKILLNSESTCPMCSERLNSSQLKKITDCSQYLRTEME", "length": 1341 }, "evidence": [ { "id": "E1B7Q4", "url": "https://omabrowser.org/oma/group/E1B7Q4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NEZ3-1", "protein_name": "WD repeat-containing protein 19", "gene_name": "WDR19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWYGDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKIQDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEYLGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLLPECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPALYSELKIMLNTESTCPMCSERLNAAQLKKISDCTQYLRTEEEL", "length": 1342 }, "evidence": [ { "id": "E1B7Q4", "url": "https://omabrowser.org/oma/group/E1B7Q4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "intraciliary retrograde transport", "id": "GO:0035721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035721", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "protein localization to non-motile cilium", "id": "GO:0097499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097499", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "protein localization to ciliary membrane", "id": "GO:1903441", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903441", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q4", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1004, "end_pos": 1006, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1182, "end_pos": 1184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" }, { "id": "PF24762", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24762" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF140/IFT172/WDR19 TPR", "eco_id": "ECO_0000259", "start_pos": 664, "end_pos": 1045, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" }, { "id": "PF23145", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT121-like zinc finger", "eco_id": "ECO_0000259", "start_pos": 1275, "end_pos": 1320, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" }, { "id": "PF15911", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15911" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WDR19 WD40 repeat", "eco_id": "ECO_0000259", "start_pos": 361, "end_pos": 635, "start_aa": "Ile", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q4" }, { "id": "PF23389", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23389" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WDR19 first beta-propeller", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 341, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1004, "end_pos": 1006 }, { "start_pos": 1182, "end_pos": 1184 }, { "start_pos": 525, "end_pos": 527 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAH7-1", "uniprot_ac": "E1BAH7", "uniprot_id": "E1BAH7_BOVIN", "mass": { "chemical_mass": 59453.0, "monoisotopic_mass": 59453.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112442669", "type": "recommended", "evidence": [ { "id": "E1BAH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAH7" } ] } ], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "E1BAH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAH7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N1L4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1L4#function" }, { "database": "UniProtKB", "id": "ARBA00003327", "url": "https://www.uniprot.org/uniprotkb/ARBA00003327#function" }, { "database": "UniProtKB", "id": "E1BAH7", "url": "https://www.uniprot.org/uniprotkb/E1BAH7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAH7", "url": "https://www.uniprot.org/uniprotkb/E1BAH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112442669", "url": "https://www.uniprot.org/uniprotkb/E1BAH7", "locus": {} } ], "crossref": [ { "id": "E1BAH7", "url": "https://alphafold.ebi.ac.uk/entry/E1BAH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040229", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040229", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000052160", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052160", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "112442669", "url": "https://www.ncbi.nlm.nih.gov/gene/112442669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262:SF248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262:SF248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N1L4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1L4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1L4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAH7", "url": "https://www.uniprot.org/uniprotkb/E1BAH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAH7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHSCCSPCCQPTCCEPSCCQPCCPPVCCQTTCCRTTCLKPTYVTTCCQPTCCESSCCRPCCPPTCYQSSENTCCRTTCCKPTCVTTCCQPACGGSSSCQPCCPPACCQTTCCRTTCLKPTCVTTCCQPTCCEPSCCRPCCPPTCYQSSENTCCRTSCCKPTCVTTCCQHNCGGSSCCQPCCLPIRCQTTCCRTTCLKPICVTTCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCGSSSGGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCQDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPCCLPIRCQTTCCRTTCLKPTCVSSCCQPTCCEPSCCRPCCPPTCYQTSENSCCRTTCCKPTCVTTCCQPNCGRSSCCQPCCLPIRCQTTCCRTTCLKPTCVSSCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCGSSSGGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCRDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPSCC", "length": 564, "header": "tr|E1BAH7-1|E1BAH7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC112442669 PE=3 SV=4 CANONICAL=E1BAH7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N1L4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1L4/entry", "sequence": { "sequence": "MTHSCCSPCCQPTCCEPSCCQPCCPPVCCQTTCCRTTCLKPTYVTTCCQPTCCESSCCRPCCPPTCYQSSENTCCRTTCCKPTCVTTCCQPACGGSSSCQPCCPPACCQTTCCRTTCLKPTCVTTCCQPTCCEPSCCRPCCPPTCYQSSENTCCRTSCCKPTCVTTCCQHNCGGSSCCQPCCLPIRCQTTCCRTTCLKPICVTTCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCGSSSGGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCQDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPSCC", "length": 334, "header": "tr|A0A3Q1N1L4-1|E1BAH7_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC112442669 PE=3 SV=2 CANONICAL=E1BAH7-1" }, "locus": { "chromosome": "19", "start_pos": 41469975, "end_pos": 41469692, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084386.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084386.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062975.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062975.2" } ] } }, { "isoform_ac": "E1BAH7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAH7/entry", "sequence": { "sequence": "MTHSCCSPCCQPTCCEPSCCQPCCPPVCCQTTCCRTTCLKPTYVTTCCQPTCCESSCCRPCCPPTCYQSSENTCCRTTCCKPTCVTTCCQPACGGSSSCQPCCPPACCQTTCCRTTCLKPTCVTTCCQPTCCEPSCCRPCCPPTCYQSSENTCCRTSCCKPTCVTTCCQHNCGGSSCCQPCCLPIRCQTTCCRTTCLKPICVTTCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCGSSSGGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCQDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPCCLPIRCQTTCCRTTCLKPTCVSSCCQPTCCEPSCCRPCCPPTCYQTSENSCCRTTCCKPTCVTTCCQPNCGRSSCCQPCCLPIRCQTTCCRTTCLKPTCVSSCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCGSSSGGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCRDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPSCC", "length": 564, "header": "tr|E1BAH7-1|E1BAH7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC112442669 PE=3 SV=4 CANONICAL=E1BAH7-1" }, "locus": { "chromosome": "19", "start_pos": 41452554, "end_pos": 41434987, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002201.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002201.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002201.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002201.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BAH7", "url": "https://www.uniprot.org/uniprotkb/E1BAH7" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "E1BAH7", "url": "https://www.uniprot.org/uniprotkb/E1BAH7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAH7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 564, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAH7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAH7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QQF6-1", "uniprot_ac": "A6QQF6", "uniprot_id": "SBSN_BOVIN", "mass": { "chemical_mass": 56854.0, "monoisotopic_mass": 56854.0 }, "refseq": { "ac": "NP_001098467", "name": "suprabasin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098467" }, "gene_names": [ { "name": "SBSN", "type": "recommended", "evidence": [ { "id": "A6QQF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQF6" } ] }, { "name": "SBSN", "type": "synonym", "evidence": [ { "id": "NP_001098467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098467" } ] } ], "protein_names": [ { "name": "Suprabasin", "type": "recommended", "evidence": [ { "id": "A6QQF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQF6/entry#names_and_taxonomy" } ] }, { "name": "suprabasin precursor", "type": "synonym", "evidence": [ { "id": "NP_001098467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098467" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQF6", "url": "https://www.uniprot.org/uniprotkb/A6QQF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SBSN", "url": "https://www.uniprot.org/uniprotkb/A6QQF6", "locus": { "chromosome": "18", "start_pos": 46186098, "end_pos": 46190848, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015915", "url": "https://www.ensembl.org/id/ENSBTAG00000015915" } ] } } ], "crossref": [ { "id": "A6QQF6", "url": "https://alphafold.ebi.ac.uk/entry/A6QQF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015915", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015915", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540452", "url": "https://www.ncbi.nlm.nih.gov/gene/540452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540452", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540452", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THHAFGQ", "url": "https://omabrowser.org/oma/group/THHAFGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQF6", "url": "https://www.orthodb.org/?gene=A6QQF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23243:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23243:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098467", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4M0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4M0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5K0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5K0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZB15", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZB15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQF6", "url": "https://www.uniprot.org/uniprotkb/A6QQF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQF6-1", "url": "https://www.uniprot.org/uniprotkb/A6QQF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHLASLLSSCSLLLLLGALPGWAANNDPIEKVIEGINRGLSSAEREVGKALEGINNGITQAGREVEKVFNGLSSMGNQAGKELEKGVQGLNRGLDKVAHGINNGVGHTGKEAEKLAHGVNHAAGQVGKEADTVIQGVPHGVNQAGSDAGRFGQGAHHATGQAGKEAEKFGQGAHHAAGQFGNEAEKFGQGAHHAAGQFGNEAEKFGQGVHHAAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHGAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHGAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGKDVHYAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQFGKEAEKFGQGAHHAAEQAGKQAGKVAQGVHDGVNQAGKEAEKLGHGVNHAAGQAGKEAEKLGQGVHHAAGQAGKQEDRLQQNVHNGVNQAGKEANQLLNDGHPGGSTTQHGGAATTTLTSGASVNKPFMALSVLWKSVTSIIP", "length": 557, "header": "sp|A6QQF6-1|SBSN_BOVIN Isoform 1 of Suprabasin OS=Bos taurus OX=9913 GN=SBSN PE=2 SV=1 CANONICAL=A6QQF6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N4M0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4M0/entry", "sequence": { "sequence": "MHLASLLSSCSLLLLLGALPGWAANNDPIEKVIEGINRGLSSAEREVGKALEGINNGITQAGREVEKVFNGLSSMGNQAGKELEKGVQGLNRGLDKVAHGINNGVGHTGKEAEKLAHGVNHAAGQVGKEADTVIQGVPHGVNQAGSDAGRFGQGAHHATGQAGKEAEKFGQGAHHAAGQFGNEAEKFGQGAHHAAGQFGNEAEKFGQGVHHAAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHGAGQFGNEAEKFGQGVHHAAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGKDVHYAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGAHHAAEQAGKQAGKVAQGVHDGVNQAGKEAEKLGHGVNHAAGQAGKEAEKLGQGVHHAAGQAGKQEDRLQQNVHNGVNQAGKEANQLLNDGHPGGSTTQHGGAATTTLTSGASVNKPFMALSVLWKSVTSIIP", "length": 503, "header": "tr|A0A3Q1N4M0-1|SBSN_BOVIN Computationally mapped isoform of Suprabasin OS=Bos taurus OX=9913 GN=SBSN PE=2 SV=2 CANONICAL=A6QQF6-1" }, "locus": { "chromosome": "18", "start_pos": 46190724, "end_pos": 46186280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064793.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064793.2" } ] } }, { "isoform_ac": "A0AAA9S5K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5K0/entry", "sequence": { "sequence": "MHLASLLSSCSLLLLLGALPGWAANNDPIEKVIEGINRGLSSAEREVGKALEGINNGITQAGREVEKVFNGLSSMGNQAGKELEKGVQGLNRGLDKVAHGINNGVGHTGKEAEKLAHGVNHAAGQVGKEADTVIQGVPHGVNQAGSDAGRFGQGAHHATGQAGKEAEKFGQGAHHAAGQFGNEAEKFGQGAHHAAGQFGNEAEKFGQGVHHAAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGKDVHYAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQFGKEAEKFGQGAHHAAEQAGKQAGKVAQGVHDGVNQAGKEAEKLGHGVNHAAGQAGKEAEKLGQGVHHAAGQAGKQEDRLQQNVHNGVNQAGKEANQLLNDGHPGGSTTQHGGAATTTLTSGASVNKPFMALSVLWKSVTSIIP", "length": 521, "header": "tr|A0AAA9S5K0-1|SBSN_BOVIN Computationally mapped isoform of Suprabasin OS=Bos taurus OX=9913 GN=SBSN PE=2 SV=1 CANONICAL=A6QQF6-1" }, "locus": { "chromosome": "18", "start_pos": 46190724, "end_pos": 46186280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115419.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115419.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080482.1" } ] } }, { "isoform_ac": "A0AAF6ZB15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB15/entry", "sequence": { "sequence": "MHLASLLSSCSLLLLLGALPGWAANNDPIEKVIEGINRGLSSAEREVGKALEGINNGITQAGREVEKVFNGLSSMGNQAGKELEKGVQGLNRGLDKVAHGINNGVGHTGKEAEKLAHGVNHAAGQVGKEADTVIQGVPHGVNQAGSDAGRFGQGAHHATGQAGKEAEKFGQGAHHAAGQFGNEAEKFGQGAHHAAGQFGNEAEKFGQGVHHAAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHGAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGKDVHYAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQFGKEAEKFGQGAHHAAEQAGKQAGKVAQGVHDGVNQAGKEAEKLGHGVNHAAGQAGKEAEKLGQGVHHAAGQAGKQEDRLQQNVHNGVNQAGKEANQLLNDGHPGGSTTQHGGAATTTLTSGASVNKPFMALSVLWKSVTSIIP", "length": 539, "header": "tr|A0AAF6ZB15-1|SBSN_BOVIN Computationally mapped isoform of Suprabasin OS=Bos taurus OX=9913 GN=SBSN PE=2 SV=1 CANONICAL=A6QQF6-1" }, "locus": { "chromosome": "18", "start_pos": 46190724, "end_pos": 46186280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032236.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032236.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032173.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032173.5" } ] } }, { "isoform_ac": "A6QQF6-1", "url": "https://www.uniprot.org/uniprotkb/A6QQF6/entry#A6QQF6-1", "sequence": { "sequence": "MHLASLLSSCSLLLLLGALPGWAANNDPIEKVIEGINRGLSSAEREVGKALEGINNGITQAGREVEKVFNGLSSMGNQAGKELEKGVQGLNRGLDKVAHGINNGVGHTGKEAEKLAHGVNHAAGQVGKEADTVIQGVPHGVNQAGSDAGRFGQGAHHATGQAGKEAEKFGQGAHHAAGQFGNEAEKFGQGAHHAAGQFGNEAEKFGQGVHHAAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHGAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHGAGQFGNEAEKFGQGVHHAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGKDVHYAAGQAGKEGEKIVQGVQHGVNQAGKEAEKFGQGVHHAAGQFGKEAEKFGQGAHHAAEQAGKQAGKVAQGVHDGVNQAGKEAEKLGHGVNHAAGQAGKEAEKLGQGVHHAAGQAGKQEDRLQQNVHNGVNQAGKEANQLLNDGHPGGSTTQHGGAATTTLTSGASVNKPFMALSVLWKSVTSIIP", "length": 557, "header": "sp|A6QQF6-1|SBSN_BOVIN Isoform 1 of Suprabasin OS=Bos taurus OX=9913 GN=SBSN PE=2 SV=1 CANONICAL=A6QQF6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540452", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540452", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0L4P5-1", "protein_name": "Suprabasin", "gene_name": "Sbsn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHLVNLLSSCCLLALLGALPARAAHEDPIEKAIEGFSRGLSNAEKEVGKALEGINNGITQAGREVERIFDGLSNMGSQAGKTVEHGLDKVAHGINSGVEHAGKEADRLAHGVNHAAGQVGKETNKIIHHGVNQGGSEAGRLGQGAHHAFGQGGSEAEKFGQGVHHAFGQGGREAEKFGQGVHHALGQGGREAEKFGQGAHHAFGQGGSETEKFGQGVHHAFGQGGREAEKFGQGAHHAFGQGGSEAEKFGQGVHHAFGQGGREAEKFGQGVHHAFGQGGSEAEKFGQGVHHAFGQGGSEAEKFGQGVHHAFGQGGSEAEKFGQGVHHAFGQGGSEAEKFGQGVHHAFGQGGREAEKFGQGIHHAFGQGGREGGKLVQGANQGLSHAAKEAQQFGHGHGHGYYAAGQTWQEGDKVMYPGVNQAGEEMERFGQGIHHTIEQAGKEAEKVAHGVQTGVNQAGKEAEKVAHGVQTGVNQAGKEAEKVAHGVQTGVNQAGKEAEKVAHGVQTGVNQAGKEAEKVAHGVQTGVNQAGKEAEKVAHGVQTGVNQAGKEAQRVGQGVNHAAGQAGKEAEKLGQGVHHAAGQAGKEMNRLQQDVHNGVNQASKEANQLLNGPHQGQSGYGGQHGGAAITTAVSGASVNKPFINFPALWRVSAACFSVPLNSLPIALLAVSILLDRLSLCRDHVTCSPSSALAFRHPLAAFGHFPVPTNKHQLTEIISRALEHPGAREGGDAETIPHVSPPIPSG", "length": 745 }, "evidence": [ { "id": "A6QQF6", "url": "https://omabrowser.org/oma/group/A6QQF6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UWP8-1", "protein_name": "Suprabasin", "gene_name": "SBSN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHLARLVGSCSLLLLLGALSGWAASDDPIEKVIEGINRGLSNAEREVGKALDGINSGITHAGREVEKVFNGLSNMGSHTGKELDKGVQGLNHGMDKVAHEINHGIGQAGKEAEKLGHGVNNAAGQVGKEADKLIHHGVHHGANQAGSEAGKFGQGVDNAAGQAGNEAGRFGQGVHHAAGQAGNEAGRFGQGVHHAAGQAGNEAGRFGQGAHHGLSEGWKETEKFGQGIHHAAGQVGKEAEKFGQGAHHAAGQAGNEAGRFGQGVHHGLSEGWKETEKFGQGVHHTAGQVGKEAEKFGQGAHHAAGQAGNEAGRFGQGAHHAAGQAGNEAGRFGQGVHHGLSEGWKETEKFGQGVHHAASQFGKETEKLGHGVHHGVNEAWKEAEKFGQGVHHAASQVGKEEDRVVQGLHHGVSQAGREAGQFGHDIHHTAGQAGKEGDIAVHGVQPGVHEAGKEAGQFGQGVHHTLEQAGKEADKAVQGFHTGVHQAGKEAEKLGQGVNHAADQAGKEVEKLGQGAHHAAGQAGKELQNAHNGVNQASKEANQLLNGNHQSGSSSHQGGATTTPLASGASVNTPFINLPALWRSVANIMP", "length": 590 }, "evidence": [ { "id": "A6QQF6", "url": "https://omabrowser.org/oma/group/A6QQF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CIT9-1", "protein_name": "Suprabasin", "gene_name": "Sbsn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYLVSLLSSCCLLVLLGTLPARAAHEDPVEKVIEGFSRGLSNAEREVGKALEGINNGITQAGREVEKIFGELSNMGSQAGKNVEHGLDKVAHDINNGIGHAGKEAEKFAHGVNHAAGQVGKETNKIIHHGVSQGGSEAGKFGQGSHHAFGQGGNVANKLGHETHHAFGQGGNVAHKLGHETHHAFGQGGNVADKLGHGGNVADKLGHGTHHAFGQGGNVADKLGHETHHAFGQGGNVADKLGHGTHHAFGQGGNVADKLGHETHHAFGQGGNVAEKLGHETHHAFGQGGNMADKFGQGAHHAFGQGGNMADKFGQGAHHAFGQGGNMADKFGQGAHHAFGQGGNMADKFGQGAHHAFGQGGNMADKFGQGAHHAFGQGGNMADKFGQGAHHAFGQGRDMAETFDQGAHHAFGQGGREGGRLVQGAGQGLSHAAKEAQQFGHGHGHGYYAAGQTWQEGDKVIHPGVSQAGEEMEQFGQGVRHTIKQAEKEAEKVAHGVQNGVNQAQKEAEKVAHGVQNGVNQAQKEAEKVAHGVQNGVNQAQKEAEKVAHGVQTGVNQAGKETQRVGQGVQTGFNQGQKEAEKVAHGVQTGVNQAGKETQKAGQGVNYAAGQAEKEAEKLGQGVHHAAGQEMNRLQQDVHNGVNQPSKEANQLLNGSHQGQGGYGGQHGGAATTTVVSGASVNKPFINFPALWRSIAATMP", "length": 700 }, "evidence": [ { "id": "A6QQF6", "url": "https://omabrowser.org/oma/group/A6QQF6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VA86-1", "protein_name": "Circumsporozoite protein", "gene_name": "Dmel\\CG9682", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKIIVVGILLVISLVGHETNAKSVANTLANQIGQDASDFGNELGQEVIQYGQEAANSGLKYGEAAENASSGWELGMDGSIFGHELGDEGNLLGQEVSNSAINFGHQVSQEAEEAASAELKAMASQSANQSSKKSVSKRDLTSSNENPSVTCACTCSTDGAASKVGNKVAESAGKAAHDVAGGAGNVASSVAGAAGTIAHDAAGAASSVASDAGHIFHDAGKVGGDIGNAAGNVAGSAANAAGNVASSVAGAAGTIAHDAAGAASSVASDAGHIFHDAGKVGGDIGSAAGNVAGDASNAAGDVAHDAANAAGSVAGSAANAAGDVANAAGNVAGDAANAAGDVAHAAGNAAGDVANAAGNVAGNASNAAGDVASAAGNVAGSVANAAGNVAGDAANAAGDVANAAGNVAGDVANAAGNVAGDVANAAGNVAGDVANAAGNVAGDVANAAGNVAHDASNIFHSIF", "length": 463 }, "evidence": [ { "id": "A6QQF6", "url": "https://omabrowser.org/oma/group/A6QQF6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A6QQF6", "url": "https://www.uniprot.org/uniprotkb/A6QQF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQF6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 557, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQF6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQF6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7Y3-1", "uniprot_ac": "E1B7Y3", "uniprot_id": "E1B7Y3_BOVIN", "mass": { "chemical_mass": 70064.0, "monoisotopic_mass": 70064.0 }, "refseq": { "ac": "NP_001179982", "name": "kelch-like protein 17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179982" }, "gene_names": [ { "name": "KLHL17", "type": "recommended", "evidence": [ { "id": "E1B7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ] }, { "name": "PLEKHN1", "type": "recommended", "evidence": [ { "id": "E1B7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ] }, { "name": "KLHL17", "type": "synonym", "evidence": [ { "id": "NP_001179982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179982" } ] }, { "name": "PLEKHN1", "type": "synonym", "evidence": [ { "id": "E1B7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ] } ], "protein_names": [ { "name": "Kelch-like protein 17", "type": "recommended", "evidence": [ { "id": "E1B7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3/entry#names_and_taxonomy" } ] }, { "name": "Actinfilin", "type": "synonym", "evidence": [ { "id": "E1B7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3/entry#names_and_taxonomy" } ] }, { "name": "kelch-like 17", "type": "synonym", "evidence": [ { "id": "NP_001179982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179982" } ] }, { "name": "kelch-like protein 17", "type": "synonym", "evidence": [ { "id": "NP_001179982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179982" } ] } ], "function": [ { "annotation": "Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function.", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3#function" }, { "database": "UniProtKB", "id": "ARBA00055422", "url": "https://www.uniprot.org/uniprotkb/ARBA00055422#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL17", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3", "locus": { "chromosome": "16", "start_pos": 51498246, "end_pos": 51513194, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013813", "url": "https://www.ensembl.org/id/ENSBTAG00000013813" } ] } } ], "crossref": [ { "id": "E1B7Y3", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Y3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013813", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013813", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13323", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13323", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18246", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18246", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615476", "url": "https://www.ncbi.nlm.nih.gov/gene/615476", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615476", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615476", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRNCWEP", "url": "https://omabrowser.org/oma/group/RRNCWEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N4N7", "url": "https://www.orthodb.org/?gene=A0A3Q1N4N7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7Y3", "url": "https://www.orthodb.org/?gene=E1B7Y3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BMJ2", "url": "https://www.orthodb.org/?gene=E1BMJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412:SF475", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF475", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46882", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46882", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46882:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46882:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179982", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4N7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4N7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4N7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Y3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMJ2", "url": "https://www.uniprot.org/uniprotkb/E1BMJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMJ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BMJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPRSERPAGRTQSPEHGSPGPAPEAPPPPPPPQPPAPEAERARPRQARPTAPMEGTMQLLSREGHAVSHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCGDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVAMLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 643, "header": "tr|E1B7Y3-1|E1B7Y3_BOVIN Isoform 1 of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=1 CANONICAL=E1B7Y3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N4N7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4N7/entry", "sequence": { "sequence": "MQPRSERPAGRTQSPEHGSPGPAPEAPPPPPPPQPPAPEAERARPRQARPTAPMEGTMQLLSREGHAVSHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCGDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVAMLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKSAATATHGEQPLRPSGP", "length": 621, "header": "tr|A0A3Q1N4N7-1|E1B7Y3_BOVIN Computationally mapped isoform of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=2 CANONICAL=E1B7Y3-1" }, "locus": { "chromosome": "16", "start_pos": 51512948, "end_pos": 51506447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064814.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064814.2" } ] } }, { "isoform_ac": "A0AAA9SW09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW09/entry", "sequence": { "sequence": "MQPRSERPAGRTQSPEHGSPGPAPEAPPPPPPPQPPAPEAERARPRQARPTAPMEGTMQLLSREGHAVSHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCGDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVAMLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKEDGARKLAGLFGTEAGADRDTTADKIFHYIPGTNIPGLQSQQEILEQPFLSVFKEGRRRAAVRSLGSVVHYAKVQLRFQHSQNVSDCYLELFPSHLYFQAHGPEGLTFQGLLPLMELSVCPLEGSREHAFQITGPLPAPLLVLCPSQAELGRWLYHLEKQIALVGGVPRCPPEPLQHRLTRLRTASGRQVMGSAICASRVKLQHLPSQEQWDRLLVLYPTSLAIFSEEADGLCFKGELPLSAIHINLEEREKQIRSFLIEGRLINTIRVVCASYEDYSHWLLCLQTVCQEDRASPPLGPESLPGLRAPTQVVASGRGSLSSDARTSWDSGCPAPASTCTSHSLPESSAPSTAGCPARPPLEQANPGCTSIGGHRAKLRRGGSSRSPRNKARAERPGPAALLHLDLTKLSLDGGTEAPDHSLETPHSPLYADPYTPPATSHRKITDVQNLDEFLSAMQSTLGPEPSSPFCSIPVSEPVSDSSCGLSGPHLLSEKAVPRARASRHHRASIKGWGPRPPDSPQLVSPEKEASPDPSPPPPDGVPRPGYGSSQDKALSPSQRRGPRGAPEPEQGLIQWI", "length": 1179, "header": "tr|A0AAA9SW09-1|E1B7Y3_BOVIN Computationally mapped isoform of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=1 CANONICAL=E1B7Y3-1" }, "locus": { "chromosome": "16", "start_pos": 51512948, "end_pos": 51499250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125256.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125256.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089507.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089507.1" } ] } }, { "isoform_ac": "A0AAA9TUK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK3/entry", "sequence": { "sequence": "MSISASQGPVWGDWRGLGWPCARAEAPCWHLGALRQRHHVQGQGCAGPCLTQALHGMPPDLTSPREDGARKLAGLFGTEAGADRDTTADKIFHYIPGTNIPGLQSQQEILEQPFLSVFKEGRRRAAVRSLGSVVHYAKVQLRFQHSQNVSDCYLELFPSHLYFQAHGPEGLTFQGLLPLMELSVCPLEGSREHAFQITGPLPAPLLVLCPSQAELGRWLYHLEKQIALVGGVPRCPPEPLQHRLTRLRTASGRQVMGSAICASRVKLQHLPSQEQWDRLLVLYPTSLAIFSEEADGLCFKGELPLSAIHINLEEREKQIRSFLIEGRLINTIRVVCASYEDYSHWLLCLQTVCQEDRASPPLGPESLPGLRAPTQVVASGRGSLSSDARTSWDSGCPAPASTCTSHSLPESSAPSTAGCPARPPLEQANPGCTSIGGHRAKLRRGGSSRSPRNKARAERPGPAALLHLDLTKLSLDGGTEAPDHSLETPHSPLYADPYTPPATSHRKITDVQNLDEFLSAMQSTLGPEPSSPFCSIPVSEPVSDSSCGLSGPHLLSEKAVPRARASRHHRASIKGWGPRPPDSPQLVSPEKEASPDPSPPPPDGVPRPGYGSSQDKALSPSQRRGPRGAPEPEQGLIQWI", "length": 640, "header": "tr|A0AAA9TUK3-1|E1B7Y3_BOVIN Computationally mapped isoform of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=1 CANONICAL=E1B7Y3-1" }, "locus": { "chromosome": "16", "start_pos": 51507293, "end_pos": 51499250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115184.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115184.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100796.1" } ] } }, { "isoform_ac": "A0AAA9TZH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZH4/entry", "sequence": { "sequence": "MQPRSERPAGRTQSPEHGSPGPAPEAPPPPPPPQPPAPEAERARPRQARPTAPMEGTMQLLSREGHAVSHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCGDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFALRRDFRSGHRRVLRPCDQHLAAGGVHGHEAQLPGCGCPAWAPVCSWWLRWGLLPQQVSRSPGVYSAERYDPLTGTWTSIAAMSTRRRYVRVAMLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 602, "header": "tr|A0AAA9TZH4-1|E1B7Y3_BOVIN Computationally mapped isoform of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=1 CANONICAL=E1B7Y3-1" }, "locus": { "chromosome": "16", "start_pos": 51512948, "end_pos": 51507944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102124.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102124.1" } ] } }, { "isoform_ac": "E1B7Y3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3/entry", "sequence": { "sequence": "MQPRSERPAGRTQSPEHGSPGPAPEAPPPPPPPQPPAPEAERARPRQARPTAPMEGTMQLLSREGHAVSHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCGDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVAMLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 643, "header": "tr|E1B7Y3-1|E1B7Y3_BOVIN Isoform 1 of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=1 CANONICAL=E1B7Y3-1" }, "locus": { "chromosome": "16", "start_pos": 51512948, "end_pos": 51507944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018351.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018351.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018351.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018351.3" } ] } }, { "isoform_ac": "E1BMJ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BMJ2/entry", "sequence": { "sequence": "MGNSHCVPQAPRRLRASFSRKPSLKGNREDGARKLAGLFGTEAGADRDTTADKIFHYIPGTNIPGLQSQQEILEQPFLSVFKEGRRRAAVRSLGSVVHYAKVQLRFQHSQNVSDCYLELFPSHLYFQAHGPEGLTFQGLLPLMELSVCPLEGSREHAFQITGPLPAPLLVLCPSQAELGRWLYHLEKQIALVGGVPRCPPEPLQHRLTRLRTASGRQVMGSAICASRVKLQHLPSQEQWDRLLVLYPTSLAIFSEEADGLCFKGELPLSAIHINLEEREKQIRSFLIEGRLINTIRVVCASYEDYSHWLLCLQTVCQEDRASPPLGPESLPGLRAPTQVVASGRGSLSSDARTSWDSGCPAPASTCTSHSLPESSAPSTAGCPARPPLEQANPGCTSIGGHRAKLRRGGSSRSPRNKARAERPGPAALLHLDLTKLSLDGGTEAPDHSLETPHSPLYADPYTPPATSHRKITDVQNLDEFLSAMQSTLGPEPSSPFCSIPVSEPVSDSSCGLSGPHLLSEKAVPRARASRHHRASIKGWGPRPPDSPQLVSPEKEASPDPSPPPPDGVPRPGYGSSQDKALSPSQRRGPRGAPEPEQGLIQWI", "length": 603, "header": "tr|E1BMJ2-1|E1B7Y3_BOVIN Computationally mapped isoform of Kelch-like protein 17 OS=Bos taurus OX=9913 GN=KLHL17 PE=4 SV=3 CANONICAL=E1B7Y3-1" }, "locus": { "chromosome": "16", "start_pos": 51506478, "end_pos": 51499250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019320.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019320.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019320.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019320.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615476", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615476", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0B4KEU3-1", "protein_name": "BTB domain-containing protein", "gene_name": "Dm.CG15097", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFLPVKSNHSGEASGNNEDVTTTSNNSTQTPSDLSPPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVLECFHLERGLVQTTNLXPLASITESFAAAAASGTSNGNSTINGIGSGGVIPSSSGVGGTLTVPSRAEAAAFTANIALSSSAPSASSTLRRHRRDTPGLAESRRANSNASSSGSESGSTSGASGSGGGKPPATAXSWSMSRRF", "length": 743 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A0A8M2B929-1", "protein_name": "Kelch-like protein 17", "gene_name": "klhl17", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMEGGMQLLNRDGHSISHNSKRHYHDSFVSMNRMRQRGLLCDIVLHVANKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDNLNVPSEEEVYRAVLSWVKHDIDGRRQHVPRLMKCVRLPLLTRDFLMSNVDTELLVRHHSECKDLLIEALKYHLMPEQRGVLSNSRTRPRRCEGASPVLFAVGGGSLFAIHGDCEAYDTRTDRWHMVASMSTRRARVGVAAIGNKLYAVGGYDGTSDLATVESYDPVTNAWQPEVSMGTRRSCLGVAVLHGLLYAAGGYDGASCLNSAERYDPLTSTWTSIAAMSTRRRYVRVATLDGSLYAVGGYDSSSHLATVEKYDPQSNAWTAIANMLSRRSSAGVAVLEGMLYVAGGNDGTSCLNSVERYNPKTNTWEGVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRSNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 591 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A9J7FBJ5-1", "protein_name": "Kelch-like protein 17 isoform X1", "gene_name": "Klhl17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPATEAERARPRQARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAIGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYPLHPAGAPWVYCLPTDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWETVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 649 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NVA2-1", "protein_name": "Kelch-like protein 17", "gene_name": "KLHL17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEGGVQLLNRDGHSISHNSKRHYHDAFVCMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVDSRRQHVPRLMKCVRLPLLSRDFLMSNVDTELLVRHHSECKDLLIEALKYHLMPEQRGVLSNSRTRPRRCEGASTVLFAVGGGSLFAIHGDCEAYDTRTDRWHMVASMSTRRARVGVAAIGNKLYAVGGYDGTSDLATVESYDPVTNSWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLEGNLYAVGGYDSSSHLATVEKYEPQINTWTPIANMLSRRSSAGVAVLEGMLYVAGGNDGTSCLNSVERYNPKTNTWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 590 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6TDP3-1", "protein_name": "Kelch-like protein 17", "gene_name": "Klhl17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 640 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6TDP4-1", "protein_name": "Kelch-like protein 17", "gene_name": "KLHL17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQPRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 642 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K430-1", "protein_name": "Kelch-like protein 17", "gene_name": "Klhl17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL", "length": 640 }, "evidence": [ { "id": "E1B7Y3", "url": "https://omabrowser.org/oma/group/E1B7Y3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cardiolipin binding", "id": "GO:1901612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901612", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y3", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Y3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 643, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Y3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Y3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y3" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 160, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCH4-1", "uniprot_ac": "E1BCH4", "uniprot_id": "E1BCH4_BOVIN", "mass": { "chemical_mass": 40334.0, "monoisotopic_mass": 40334.0 }, "refseq": {}, "gene_names": [ { "name": "DUSP11", "type": "recommended", "evidence": [ { "id": "E1BCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ] } ], "protein_names": [ { "name": "RNA/RNP complex-1-interacting phosphatase", "type": "recommended", "evidence": [ { "id": "E1BCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH4/entry#names_and_taxonomy" } ] }, { "name": "Dual specificity protein phosphatase 11", "type": "synonym", "evidence": [ { "id": "E1BCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH4/entry#names_and_taxonomy" } ] }, { "name": "Phosphatase that interacts with RNA/RNP complex 1", "type": "synonym", "evidence": [ { "id": "E1BCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4#function" }, { "database": "UniProtKB", "id": "ARBA00054725", "url": "https://www.uniprot.org/uniprotkb/ARBA00054725#function" }, { "database": "UniProtKB", "id": "A0A3Q1N7C4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7C4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DUSP11", "url": "https://www.uniprot.org/uniprotkb/E1BCH4", "locus": { "chromosome": "11", "start_pos": 10864268, "end_pos": 10848281, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033255", "url": "https://www.ensembl.org/id/ENSBTAG00000033255" } ] } } ], "crossref": [ { "id": "E1BCH4", "url": "https://alphafold.ebi.ac.uk/entry/E1BCH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17665", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17665", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N7C4", "url": "https://www.orthodb.org/?gene=A0A3Q1N7C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCH4", "url": "https://www.orthodb.org/?gene=E1BCH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10367:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10367:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N7C4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7C4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7C4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQWHHVGGHWGQDRVFSGYSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLKKSFEKHLAPEECFSPLDLFNKIQEQNEELGLIIDLTYTRRYYKPEELPENFPYLKIYTVGHQVPDDDTIFKFKNAVNGFLRENKDNDRLIGVHCTHGVNRTGYLICRYLIDVEGMRPDDAIELFSRCRGHCLERQNYIDDLRNGPIRKNWDSSVSRTRGFEDSTHMMEPVFTATKPVNRRPKHNIHQTQGYPEPRHFHTWTQDLQQSERGGNGNPLQCSCLENPRDRGAWWAAVYGVAQSRTRLKRLSCSSSSRDLQGESSFLFANINSSFCFLSALPHLERIYLIRIV", "length": 347, "header": "tr|E1BCH4-1|E1BCH4_BOVIN Isoform 1 of RNA/RNP complex-1-interacting phosphatase OS=Bos taurus OX=9913 GN=DUSP11 PE=3 SV=2 CANONICAL=E1BCH4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N7C4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7C4/entry", "sequence": { "sequence": "GWMACRLDGREWKDYLPVGQRMPGTRFIAFKVPLKKSFEKHLAPEECFSPLDLFNKIQEQNEELGLIIDLTYTRRYYKPEELPENFPYLKIYTVGHQVPDDDTIFKFKNAVNGFLRENKDNDRLIGVHCTHGVNRTGYLICRYLIDVEGMRPDDAIELFSRCRGHCLERQNYIDDLRNGPIRKNWDSSVSRTRGFEDSTHMMEPVFTATKPVNRRPKHNIHQTQGYPEPRHFHTWTQDLQQSERYLCFPFKFSRNWNIYQRCHVPPPGPPGEDYFQRRYSWNVKPSAGQGGPNKRFSPGSYYRVPYSAYYRWTK", "length": 314, "header": "tr|A0A3Q1N7C4-1|E1BCH4_BOVIN Computationally mapped isoform of RNA/RNP complex-1-interacting phosphatase OS=Bos taurus OX=9913 GN=DUSP11 PE=3 SV=2 CANONICAL=E1BCH4-1" }, "locus": { "chromosome": "11", "start_pos": 10863971, "end_pos": 10849735, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073996.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073996.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066554.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066554.2" } ] } }, { "isoform_ac": "A0AAA9SAR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR8/entry", "sequence": { "sequence": "MSQWHHVGGHWGQDRVFSGYSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLKKSFEKHLAPEECFSPLDLFNKIQEQNEELGLIIDLTYTRRYYKPEELPENFPYLKIYTVGHQVPDDDTIFKFKNAVNGFLRENKDNGEFFSLPEFWYAFQ", "length": 158, "header": "tr|A0AAA9SAR8-1|E1BCH4_BOVIN Computationally mapped isoform of RNA/RNP complex-1-interacting phosphatase OS=Bos taurus OX=9913 GN=DUSP11 PE=3 SV=1 CANONICAL=E1BCH4-1" }, "locus": { "chromosome": "11", "start_pos": 10855232, "end_pos": 10848391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120591.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120591.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082439.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082439.1" } ] } }, { "isoform_ac": "E1BCH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCH4/entry", "sequence": { "sequence": "MSQWHHVGGHWGQDRVFSGYSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLKKSFEKHLAPEECFSPLDLFNKIQEQNEELGLIIDLTYTRRYYKPEELPENFPYLKIYTVGHQVPDDDTIFKFKNAVNGFLRENKDNDRLIGVHCTHGVNRTGYLICRYLIDVEGMRPDDAIELFSRCRGHCLERQNYIDDLRNGPIRKNWDSSVSRTRGFEDSTHMMEPVFTATKPVNRRPKHNIHQTQGYPEPRHFHTWTQDLQQSERGGNGNPLQCSCLENPRDRGAWWAAVYGVAQSRTRLKRLSCSSSSRDLQGESSFLFANINSSFCFLSALPHLERIYLIRIV", "length": 347, "header": "tr|E1BCH4-1|E1BCH4_BOVIN Isoform 1 of RNA/RNP complex-1-interacting phosphatase OS=Bos taurus OX=9913 GN=DUSP11 PE=3 SV=2 CANONICAL=E1BCH4-1" }, "locus": { "chromosome": "11", "start_pos": 10863477, "end_pos": 10848391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047256.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047256.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044476.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044476.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" }, { "name": "phosphoprotein phosphatase activity", "id": "GO:0004721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004721", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" }, { "name": "polynucleotide 5'-phosphatase activity", "id": "GO:0004651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004651", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1BCH4", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCH4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 347, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCH4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCH4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 197, "start_aa": "Phe", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BCH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH4" }, { "id": "PS50054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 208, "start_aa": "Phe", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 326, "end_pos": 328 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCC1-1", "uniprot_ac": "E1BCC1", "uniprot_id": "E1BCC1_BOVIN", "mass": { "chemical_mass": 82901.0, "monoisotopic_mass": 82901.0 }, "refseq": { "ac": "XP_002687609", "name": "rho GTPase-activating protein 9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687609" }, "gene_names": [ { "name": "ARHGAP9", "type": "recommended", "evidence": [ { "id": "E1BCC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ] }, { "name": "ARHGAP9", "type": "synonym", "evidence": [ { "id": "XP_002687609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687609" } ] } ], "protein_names": [ { "name": "Rho GTPase activating protein 9", "type": "synonym", "evidence": [ { "id": "E1BCC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC1/entry#names_and_taxonomy" } ] }, { "name": "rho GTPase-activating protein 9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687609" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP9", "url": "https://www.uniprot.org/uniprotkb/E1BCC1", "locus": { "chromosome": "5", "start_pos": 55993413, "end_pos": 55984054, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018403", "url": "https://www.ensembl.org/id/ENSBTAG00000018403" } ] } } ], "crossref": [ { "id": "E1BCC1", "url": "https://alphafold.ebi.ac.uk/entry/E1BCC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018403", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018403", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04403", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04403", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12143", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12143", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13233", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13233", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507960", "url": "https://www.ncbi.nlm.nih.gov/gene/507960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507960", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507960", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N7J9", "url": "https://www.orthodb.org/?gene=A0A3Q1N7J9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCC1", "url": "https://www.orthodb.org/?gene=E1BCC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23176:SF103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23176:SF103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687609", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687609", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7J9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7J9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7J9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLTTMLSGRWWPSTWGNLGLGSRSPSRGSQLCALYAFTYTGADGRQVSLAEGDRFLLLRKTNSDWWLARRLGAPSTSRPVFVPAAYMIEESSPSHSPTTITPSQSLWTHGPKLLPGSLEEMNLCQEPPGRAQATSEQPPPLPPKMCRSVSVTNLRPSLLKPFREGPSGRSLSQENLLTKTDANVARPQTLMSKAPVYCNLVDLRRCPRSPPSSPSCPPLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRHTRTRETNPSSMEGTQTLNRDNGILQPQAKDEESGPKTSELFDSQGSPYLCRRTSQLDPGKPSSLQCPRPLPTVLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLAGNSLVFYREPPPTAPATAWGPAGSRPESSVDLRGAALAHGRHLSSRRHVLHIRTVPGHEFLLQSDQEAELRAWHSALRAVIERLDRENPLEGRLSGSGPAELEELSPGEDEEEESEPVSKSLLRIGGRRSSSRCPETAEQNRVRNKLKRLIAKRPPLQTLQERGLLRDQVFGCQLESLCQREGDTVPSFVRLCVAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAITSDGRYMFPEQPGQEGRLDLDSAEWDDIHVITGALKLFLRELPQPLVPSLLLPDFRAAVALTESEQCLSQIQELISSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPVAHVLYPGQVVQLMLTNFTRVFP", "length": 745, "header": "tr|E1BCC1-1|E1BCC1_BOVIN Isoform 1 of Rho GTPase activating protein 9 OS=Bos taurus OX=9913 GN=ARHGAP9 PE=4 SV=4 CANONICAL=E1BCC1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N7J9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7J9/entry", "sequence": { "sequence": "MVLTTMLSGRWWPSTWGNLGLGSRSPSRGSQLCALYAFTYTGADGRQVSLAEGDRFLLLRKTNSDWWLARRLGAPSTSRPVFVPAAYMIEESSPSHSPTTITPSQSLWTHGPKLLPGSLEEMNLCQEPPGRAQATSEQPPPLPPKMCRSVSVTNLRPSLLKPFREGPSGRSLSQENLLTKTDANVARPQTLMSKAPVYCNLVDLRRCPRSPPSSPSCPPLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRHTRTRETNPSSMEGTQTLNRDNGILQPQAKDEESGPKTSELFDSQGSPYLCRRTSQLDPGKPSSLQCPRPLPTVLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLAGNSLVFYREPPPTAPATAWGPAGSRPESSVDLRGAALAHGRHLSSRRHVLHIRTVPGHEFLLQSDQEAELRAWHSALRAVIERLDRENPLEGRLSGSGPAELEELSPGEDEEEESEPVSKSLLRIGGRRSSSRCPETAEQNRVRNKLKRLIAKRPPLQTLQERGLLRDQVFGCQLESLCQREGDTVPSFVRLCVAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAITSDGRYMFPEQPGQEGRLDLDSAEWDDIHVITGALKLFLRELPQPLVPSLLLPDFRAAVG", "length": 654, "header": "tr|A0A3Q1N7J9-1|E1BCC1_BOVIN Computationally mapped isoform of Rho GTPase activating protein 9 OS=Bos taurus OX=9913 GN=ARHGAP9 PE=4 SV=2 CANONICAL=E1BCC1-1" }, "locus": { "chromosome": "5", "start_pos": 55992242, "end_pos": 55985209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068575.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068575.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066711.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066711.2" } ] } }, { "isoform_ac": "E1BCC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1/entry", "sequence": { "sequence": "MVLTTMLSGRWWPSTWGNLGLGSRSPSRGSQLCALYAFTYTGADGRQVSLAEGDRFLLLRKTNSDWWLARRLGAPSTSRPVFVPAAYMIEESSPSHSPTTITPSQSLWTHGPKLLPGSLEEMNLCQEPPGRAQATSEQPPPLPPKMCRSVSVTNLRPSLLKPFREGPSGRSLSQENLLTKTDANVARPQTLMSKAPVYCNLVDLRRCPRSPPSSPSCPPLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRHTRTRETNPSSMEGTQTLNRDNGILQPQAKDEESGPKTSELFDSQGSPYLCRRTSQLDPGKPSSLQCPRPLPTVLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLAGNSLVFYREPPPTAPATAWGPAGSRPESSVDLRGAALAHGRHLSSRRHVLHIRTVPGHEFLLQSDQEAELRAWHSALRAVIERLDRENPLEGRLSGSGPAELEELSPGEDEEEESEPVSKSLLRIGGRRSSSRCPETAEQNRVRNKLKRLIAKRPPLQTLQERGLLRDQVFGCQLESLCQREGDTVPSFVRLCVAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAITSDGRYMFPEQPGQEGRLDLDSAEWDDIHVITGALKLFLRELPQPLVPSLLLPDFRAAVALTESEQCLSQIQELISSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPVAHVLYPGQVVQLMLTNFTRVFP", "length": 745, "header": "tr|E1BCC1-1|E1BCC1_BOVIN Isoform 1 of Rho GTPase activating protein 9 OS=Bos taurus OX=9913 GN=ARHGAP9 PE=4 SV=4 CANONICAL=E1BCC1-1" }, "locus": { "chromosome": "5", "start_pos": 55992409, "end_pos": 55985209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024486.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024486.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024486.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024486.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 377, "start_aa": "Thr", "end_pos": 377, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr377", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507960", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507960", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate binding", "id": "GO:0005547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005547", "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCC1", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 739, "end_pos": 741, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCC1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 745, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCC1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCC1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 333, "end_pos": 446, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BCC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 537, "end_pos": 744, "start_aa": "Cys", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BCC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 93, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BCC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC1" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 226, "end_pos": 254, "start_aa": "Trp", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 377 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 341, "end_pos": 343 }, { "start_pos": 739, "end_pos": 741 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB14-1", "uniprot_ac": "E1BB14", "uniprot_id": "E1BB14_BOVIN", "mass": { "chemical_mass": 37254.0, "monoisotopic_mass": 37254.0 }, "refseq": { "ac": "NP_001179276", "name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179276" }, "gene_names": [ { "name": "GNB3", "type": "recommended", "evidence": [ { "id": "E1BB14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ] }, { "name": "GNB3", "type": "synonym", "evidence": [ { "id": "NP_001179276", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179276" } ] } ], "protein_names": [ { "name": "G protein subunit beta 3", "type": "synonym", "evidence": [ { "id": "E1BB14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB14/entry#names_and_taxonomy" } ] }, { "name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "type": "synonym", "evidence": [ { "id": "NP_001179276", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179276" } ] } ], "function": [ { "annotation": "Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NGS8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGS8#function" }, { "database": "UniProtKB", "id": "ARBA00045289", "url": "https://www.uniprot.org/uniprotkb/ARBA00045289#function" } ] }, { "annotation": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14#function" }, { "database": "UniProtKB", "id": "ARBA00002002", "url": "https://www.uniprot.org/uniprotkb/ARBA00002002#function" }, { "database": "UniProtKB", "id": "A0AAA9ST18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST18#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNB3", "url": "https://www.uniprot.org/uniprotkb/E1BB14", "locus": { "chromosome": "5", "start_pos": 103602567, "end_pos": 103610294, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016043", "url": "https://www.ensembl.org/id/ENSBTAG00000016043" } ] } } ], "crossref": [ { "id": "E1BB14", "url": "https://alphafold.ebi.ac.uk/entry/E1BB14", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016043", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016043", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513340", "url": "https://www.ncbi.nlm.nih.gov/gene/513340", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513340", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513340", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VYSHETI", "url": "https://omabrowser.org/oma/group/VYSHETI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NGS8", "url": "https://www.orthodb.org/?gene=A0A3Q1NGS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BB14", "url": "https://www.orthodb.org/?gene=E1BB14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296041", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202040", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202040", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381676", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381771", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392451", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392451", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392851", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392851", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-400042", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-400042", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086398", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418217", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418217", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418592", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418592", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418597", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-428930", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428930", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432040", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432040", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-456926", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-456926", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-500657", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-500657", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6814122", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8964315", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964315", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8964616", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964616", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9009391", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9856530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-997272", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179276", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGS8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB14-1", "url": "https://www.uniprot.org/uniprotkb/E1BB14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEMEQLRQEAEQLKKQIADARKACADTTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFRLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTTYAHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340, "header": "tr|E1BB14-1|E1BB14_BOVIN Isoform 1 of G protein subunit beta 3 OS=Bos taurus OX=9913 GN=GNB3 PE=3 SV=1 CANONICAL=E1BB14-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGS8/entry", "sequence": { "sequence": "MLTNFLQLVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFRLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTTYAHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 315, "header": "tr|A0A3Q1NGS8-1|E1BB14_BOVIN Computationally mapped isoform of G protein subunit beta 3 OS=Bos taurus OX=9913 GN=GNB3 PE=3 SV=2 CANONICAL=E1BB14-1" }, "locus": { "chromosome": "5", "start_pos": 103606777, "end_pos": 103603060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082648.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082648.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071051.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071051.2" } ] } }, { "isoform_ac": "A0AAA9ST18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST18/entry", "sequence": { "sequence": "MVVGGGRRCGWPGRRQETKEPPLKPSAMGEMEQLRQEAEQLKKQIADARKACADTTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFRLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTTYAHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 367, "header": "tr|A0AAA9ST18-1|E1BB14_BOVIN Computationally mapped isoform of G protein subunit beta 3 OS=Bos taurus OX=9913 GN=GNB3 PE=3 SV=1 CANONICAL=E1BB14-1" }, "locus": { "chromosome": "5", "start_pos": 103610095, "end_pos": 103603060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104863.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104863.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087261.1" } ] } }, { "isoform_ac": "E1BB14-1", "url": "https://www.uniprot.org/uniprotkb/E1BB14/entry", "sequence": { "sequence": "MGEMEQLRQEAEQLKKQIADARKACADTTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFRLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTTYAHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340, "header": "tr|E1BB14-1|E1BB14_BOVIN Isoform 1 of G protein subunit beta 3 OS=Bos taurus OX=9913 GN=GNB3 PE=3 SV=1 CANONICAL=E1BB14-1" }, "locus": { "chromosome": "5", "start_pos": 103608671, "end_pos": 103603060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021348.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021348.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021348.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021348.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513340", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513340", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296041", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "resource": "Reactome", "description": "Activation of G protein gated Potassium channels" }, { "id": "R-BTA-202040", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202040", "resource": "Reactome", "description": "G-protein activation" }, { "id": "R-BTA-381676", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "resource": "Reactome", "description": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion" }, { "id": "R-BTA-381771", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381771", "resource": "Reactome", "description": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)" }, { "id": "R-BTA-392170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392170", "resource": "Reactome", "description": "ADP signalling through P2Y purinoceptor 12" }, { "id": "R-BTA-392451", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392451", "resource": "Reactome", "description": "G beta:gamma signalling through PI3Kgamma" }, { "id": "R-BTA-392851", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392851", "resource": "Reactome", "description": "Prostacyclin signalling through prostacyclin receptor" }, { "id": "R-BTA-400042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-400042", "resource": "Reactome", "description": "Adrenaline,noradrenaline inhibits insulin secretion" }, { "id": "R-BTA-4086398", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "resource": "Reactome", "description": "Ca2+ pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-418217", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418217", "resource": "Reactome", "description": "G beta:gamma signalling through PLC beta" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-418592", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418592", "resource": "Reactome", "description": "ADP signalling through P2Y purinoceptor 1" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-418597", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418597", "resource": "Reactome", "description": "G alpha (z) signalling events" }, { "id": "R-BTA-420092", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "resource": "Reactome", "description": "Glucagon-type ligand receptors" }, { "id": "R-BTA-428930", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428930", "resource": "Reactome", "description": "Thromboxane signalling through TP receptor" }, { "id": "R-BTA-432040", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432040", "resource": "Reactome", "description": "Vasopressin regulates renal water homeostasis via Aquaporins" }, { "id": "R-BTA-456926", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-456926", "resource": "Reactome", "description": "Thrombin signalling through proteinase activated receptors (PARs)" }, { "id": "R-BTA-500657", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-500657", "resource": "Reactome", "description": "Presynaptic function of Kainate receptors" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" }, { "id": "R-BTA-8964315", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964315", "resource": "Reactome", "description": "G beta:gamma signalling through BTK" }, { "id": "R-BTA-8964616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964616", "resource": "Reactome", "description": "G beta:gamma signalling through CDC42" }, { "id": "R-BTA-9009391", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9009391", "resource": "Reactome", "description": "Extra-nuclear estrogen signaling" }, { "id": "R-BTA-9717207", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "resource": "Reactome", "description": "Sensory perception of sweet, bitter, and umami (glutamate) taste" }, { "id": "R-BTA-9856530", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856530", "resource": "Reactome", "description": "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells" }, { "id": "R-BTA-997272", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "resource": "Reactome", "description": "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P7Z5-1", "protein_name": "G protein subunit beta 3", "gene_name": "GNB3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGEMEQMKQEAEQLKKQIADARKACADTTLAQIVSGVEVVGRIQMRTRRTLRGHLAKIYAMHWSTDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKTREGNVKVSRELSAHTGYLSCCRFLDDNSIVTSSGDTTCALWDIETGQQKTVFLGHTGDCMSLAVSPDFKLFISGACDATAKLWDVREGTCRQTFSGHESDINAICFFPNGEAICTGSDDATCRLFDLRADQELIVYSHESIICGITSVAFSRSGRLLLAGYDDFNCNIWDSLKAERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2MA36-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1", "gene_name": "Gnb3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEMEQLRQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SLU8-1", "protein_name": "G protein subunit beta 3", "gene_name": "GNB3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEMEQLRQEAEQLKKQIADARKACADTTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTTYSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKCERVGTLSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P16520-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "gene_name": "GNB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P52287-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "gene_name": "Gnb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEMEQLKQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSLKCERVGVLSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61011-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "gene_name": "Gnb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEMEQLRQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSQESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSLKCERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6DH55-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a", "gene_name": "gnb3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGEMEQLRKEAEKLKDDITAARKTVQDLTLQDHVAGTAVVGRVQLKTRKTLRGHLAKIYAMHWGTDSKLCVSASQDGKLIVWDSYTTNKVHAIPLKSSWVMTCSYAPSGNMVACGGLDNMCSIYNLKAKDGNVKVMRELAAHTGYLSCCRFLSDSEIITSSGDCTCVLWDIETGSQKTVFAGHLGDCMSLAVSPDFNTFISGACDFTAKLWDIREGQCRQTFGGHESDINAIGFFPNGNAVITGSDDASCKLYDLRSDQELITYQDSSIMCGVTSIAPSLSGRLILAGYDDFNCNIWDSLKSERVGVLSGHDNRVSCIGVTPDGMACCTGSWDSFLKIWN", "length": 340 }, "evidence": [ { "id": "E1BB14", "url": "https://omabrowser.org/oma/group/E1BB14/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of cholesterol metabolic process", "id": "GO:0090181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090181", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of glucose metabolic process", "id": "GO:0010906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010906", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of phospholipid metabolic process", "id": "GO:1903725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903725", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of fat cell differentiation", "id": "GO:0045598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045598", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of triglyceride metabolic process", "id": "GO:0090207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090207", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "regulation of hormone metabolic process", "id": "GO:0032350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032350", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "heterotrimeric G-protein complex", "id": "GO:0005834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005834", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase binding", "id": "GO:0051020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051020", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" }, { "name": "signaling receptor complex adaptor activity", "id": "GO:0030159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030159", "evidence": [ { "database": "UniProtKB", "id": "E1BB14", "url": "https://www.uniprot.org/uniprotkb/E1BB14" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8U2-1", "uniprot_ac": "E1B8U2", "uniprot_id": "THUM2_BOVIN", "mass": { "chemical_mass": 55225.0, "monoisotopic_mass": 55225.0 }, "refseq": { "ac": "NP_001179151", "name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179151" }, "gene_names": [ { "name": "THUMPD2", "type": "recommended", "evidence": [ { "id": "E1B8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ] }, { "name": "THUMPD2", "type": "synonym", "evidence": [ { "id": "NP_001179151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179151" } ] } ], "protein_names": [ { "name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "type": "recommended", "evidence": [ { "id": "E1B8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U2/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.-", "type": "synonym", "evidence": [ { "id": "E1B8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U2/entry#names_and_taxonomy" } ] }, { "name": "THUMP domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179151" }, { "id": "E1B8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U2/entry#names_and_taxonomy" } ] }, { "name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "type": "synonym", "evidence": [ { "id": "NP_001179151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179151" } ] } ], "function": [ { "annotation": "Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome (PubMed:37283053). This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2#function" }, { "database": "PubMed", "id": "37283053", "url": "https://glygen.org/publication/PubMed/37283053" }, { "database": "UniProtKB", "id": "Q9BTF0", "url": "https://www.uniprot.org/uniprotkb/Q9BTF0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THUMPD2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2", "locus": { "chromosome": "11", "start_pos": 22040726, "end_pos": 22080776, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004722", "url": "https://www.ensembl.org/id/ENSBTAG00000004722" } ] } } ], "crossref": [ { "id": "E1B8U2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8U2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004722", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004722", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11715", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11715", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509460", "url": "https://www.ncbi.nlm.nih.gov/gene/509460", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509460", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509460", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QWTSAVM", "url": "https://omabrowser.org/oma/group/QWTSAVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJK3", "url": "https://www.orthodb.org/?gene=A0A3Q1NJK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8U2", "url": "https://www.orthodb.org/?gene=E1B8U2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14911:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14911:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00078", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00078", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179151", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "83423", "url": "https://www.rhea-db.org/rhea/83423", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NJK3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVVPGGPSSRPAVGAQFFCTAGRGLEPFLMREVRERLAATQVEYISGKVFFTTCSDLNMLKQLKSAERLFLLIKKQLPFPVSSVSKGKILNELQRLINDDPESWLNAISIWKNLLELDAKKEKLSHKNANPLKRKVGEDDITAKKLKTEQIQELQETKECQLEKQIEEKILEQGNFITEGEKFQKLQDDVTEAVDTRNQTNLTFRVSCRCSGAVAKTLTAQEVGRVIGIALMKQFGWKADLRNPNLEIFIHLSDVYSVLGIPVFRVPLACRAYIKTAGLRSTIAWAMASLAEIKAGAVVLDPMCGLGTILLEAAKEWPHVYYVGADVSDSQLSGAYDNLRAAGLRDKIELLQVSVIELPLPSESVDIIISDIPFGKKFKLGKDIKRMLQEMERVLRVGGTIVLLLSEDHHRHLKGGEASSGPLNSQGGHTEEPGGEERLTPAEKAAVSEPVSSPFAASNQGRLDRMPPLGSLVPVDCYRVSLGKTDALISKYKKSHSPGR", "length": 501, "header": "sp|E1B8U2-1|THUM2_BOVIN Isoform 1 of U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 OS=Bos taurus OX=9913 GN=THUMPD2 PE=1 SV=3 CANONICAL=E1B8U2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NJK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJK3/entry", "sequence": { "sequence": "MAVVPGGPSSRPAVGAQFFCTAGRGLEPFLMREVRERLAATQVEYISGKVFFTTCSDLNMLKQLKSAERLFLLIKKQLPFPVSSVSKGKILNELQRLINDDPESWLNAISIWKNLLELDAKKEKLSHKNANPLKRKVGEDDITAKKLKTEQIQELQETKECQLEKQIEEKILEQGNFITEGEKFQKLQDDVTEAVDTRNQTNLTFRVSCRCSGAVAKTLTAQEVGRVIGIALMKQFGWKADLRNPNLEIFIHLSDVYSVLGIPVFRVPLACRAYIKTAGLRSTIAWAMASLAEIKHVYYVGADVSDSQLSGAYDNLRAAGLRDKIELLQVSVIELPLPSESVDIIISDIPFGKKFKLGKDIKRMLQEMERVLRVGGTIVLLLSEDHHRHLKGGEASSGPLNSQGGHTEEPGGEERLTPAEKAAVSEPVSSPFAASNQGRLDRMPPLGSLVPVDCYRVSLGKTDALISKYKKSHSPGR", "length": 477, "header": "tr|A0A3Q1NJK3-1|THUM2_BOVIN Computationally mapped isoform of U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 OS=Bos taurus OX=9913 GN=THUMPD2 PE=1 SV=1 CANONICAL=E1B8U2-1" }, "locus": { "chromosome": "11", "start_pos": 22080766, "end_pos": 22041354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076632.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076632.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072361.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072361.1" } ] } }, { "isoform_ac": "A0AAA9S1C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C7/entry", "sequence": { "sequence": "MAVVPGGPSSRPAVGAQFFCTAGRGLEPFLMREVRERLAATQVEYISGKVFFTTCSDLNMLKQLKSAERLFLLIKKQLPFPVSSVSKGKILNELQRLINDDPESWLNAISIWKNLLELDAKKEKLSHKNANPLKRKVGEDDITAKKLKTEQIQELQETKECQLEKQIEEKILEQGNFITEGEKFQKLQDDVTEAVDTRNQTNLTFRVSCRCSGAVAKTLTAQEVGRVIGIALMKQFGWKADLRNPNLEIFIHLSDVYSVLGIPVFRVPLACRAYIKTAGLRSTIAWAMASLAEIKHVYYVGADVSDSQLSGAYDNLRAAGLRDKIELLQVSVIESIMRNAGLEEAQAGIKIAGRNINNLRYADDTTLMAESEEKLKSLLMKVKEESEKVGLKLNIQKTKIMASGPITSWEIDGETVETVSDFIFLGSKITADGDCSHEIERRLLLGRKVMTNLDSILKSRDITLPTKVHLVKAMVFPVFMYGCESW", "length": 486, "header": "tr|A0AAA9S1C7-1|THUM2_BOVIN Computationally mapped isoform of U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 OS=Bos taurus OX=9913 GN=THUMPD2 PE=1 SV=1 CANONICAL=E1B8U2-1" }, "locus": { "chromosome": "11", "start_pos": 22080766, "end_pos": 22054699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091707.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091707.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077115.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077115.1" } ] } }, { "isoform_ac": "E1B8U2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U2/entry#E1B8U2-1", "sequence": { "sequence": "MAVVPGGPSSRPAVGAQFFCTAGRGLEPFLMREVRERLAATQVEYISGKVFFTTCSDLNMLKQLKSAERLFLLIKKQLPFPVSSVSKGKILNELQRLINDDPESWLNAISIWKNLLELDAKKEKLSHKNANPLKRKVGEDDITAKKLKTEQIQELQETKECQLEKQIEEKILEQGNFITEGEKFQKLQDDVTEAVDTRNQTNLTFRVSCRCSGAVAKTLTAQEVGRVIGIALMKQFGWKADLRNPNLEIFIHLSDVYSVLGIPVFRVPLACRAYIKTAGLRSTIAWAMASLAEIKAGAVVLDPMCGLGTILLEAAKEWPHVYYVGADVSDSQLSGAYDNLRAAGLRDKIELLQVSVIELPLPSESVDIIISDIPFGKKFKLGKDIKRMLQEMERVLRVGGTIVLLLSEDHHRHLKGGEASSGPLNSQGGHTEEPGGEERLTPAEKAAVSEPVSSPFAASNQGRLDRMPPLGSLVPVDCYRVSLGKTDALISKYKKSHSPGR", "length": 501, "header": "sp|E1B8U2-1|THUM2_BOVIN Isoform 1 of U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 OS=Bos taurus OX=9913 GN=THUMPD2 PE=1 SV=3 CANONICAL=E1B8U2-1" }, "locus": { "chromosome": "11", "start_pos": 22080766, "end_pos": 22041354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006195.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006195.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006195.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006195.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing.", "journal": "Nucleic acids research", "date": "2023-08-11", "authors": "Wang Can, Ulryck Nathalie, Herzel Lydia, Pythoud Nicolas, Kleiber Nicole, Gu\u00e9rineau Vincent, Jactel Vincent, Moritz Chlo\u00e9, Bohnsack Markus T, Carapito Christine, Touboul David, Bohnsack Katherine E, Graille Marc", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "reference": [ { "type": "PubMed", "id": "37283053", "url": "https://glygen.org/publication/PubMed/37283053" } ] } ], "pathway": [ { "id": "bta:509460", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509460", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KA02-1", "protein_name": "THUMP domain containing 2", "gene_name": "Thumpd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAGADPGSEPAGGAQFFCTAGRGLEPFLMREVRARLEATQVEYISGKVFFTTCSDLPSMKKLKSAERLFLLIKKQLPITVSSLHRGRLLNEMQRFINDDPGSWLKAISLWRKLLDHDTNGEKVSQGDANPLKRKAGENDSITPKKLKLEEMQVVDKSHGESQQDQPQGPLEQGETLARTDELQEQRLHRASETAAHAQSPEDLTFRISCRCSGSIRKVVTGQEAGRVAGLALMRQFGWKADLRKPDLEIFMHLSDAYSVVGIPLLRVPLASRTYLQTAGLRSTIAWAMASIAEIKAGALVLDPMCGLGTILVEAAEEWPDVFYVGADVSDSQLLGACDNLKAAGLAHRIELLKGSVADLPLPAQSVDVIISDIPFGKKFKLGKDIKSILQEMERWPLWRKGTEYPAGEGDHPGCAVGIVKRCLPTEVAAEGVLHVDGVMILLLSEDHHRRLTDCGGSSMPPTSQGNVSDPEMKMLLNPDRTGAPDTASPSQKASSLQSLGRPLPCGSLVPVESFKVSLGKTDAFICKYKKASASGLSPSRCHEPGAHPEVAAMQGSPGLQDSICPGAPSAQPLPVGMAKNTAVR", "length": 586 }, "evidence": [ { "id": "E1B8U2", "url": "https://omabrowser.org/oma/group/E1B8U2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287B0I2-1", "protein_name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "gene_name": "THUMPD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVTEDLHFGPAAGTRFFCTASRGLEPFLLREVRTRLRATQVEYISGKVFFTTCCDLNMLKRLKSAERLFLLIKKQFPFNVSSVSKGQIFNEMEKLINDDPENWLNTLSIWKNLLEFDAKEEELSQKDVNSLKRKVGEDDNTIAKKVKTEQVQEIHENKECQREKQTEETLEQGNCITQREELQEEELQNDAVEAVDTPTKGKHLTFRVSCRCSGAIAKTFTTQEIGRVIGIALKKQFGWKVDLRNPNLEIFIHLSDIYSVVGIPVFRVPLASRAYIKTAGLRSTIAWAMASLAEIKAGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGASDNLKAAGLKDKIELLKGSVIELPLPSESVDIIISDIPFGKKFKLGKDIKSILQEMERVLHVGGTIVLLLSGDHLRRLKGCEESSVSLCPKGSRTDEPGSEECLNPEEKAAVPEPAWSSLEASNQEHLDRMPPFGSLVPVECYKVSLGKPDAFIYKYKKSHSPGQ", "length": 504 }, "evidence": [ { "id": "E1B8U2", "url": "https://omabrowser.org/oma/group/E1B8U2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z076-1", "protein_name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "gene_name": "THUMPD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGARYFCTAGRGLEPFLAREVRARLGATEVDYVLGKVFFTTAAEPGELKELKSGERLFLLLKKCVPLSVSRNKGKMLHEIKSLLTEEPKSCLDVIATWRKLRSHEGKKDEASQENRSPHKRKPEEEINIASKRQKTEQVREIASEECQAGAGENCVVSEEESDQDCQAESKASLEGPTRSSIEKPIENEKQNFSFRVSCRCSGAIAKILTSQEIGRAVGIALRKQFGWQADLRAPDLEIFLHLNDIHSVVGIPLFRLPLANREYIKTAGLRSTVAWAMASLAEISVGAFVLDPMCGLGTILLEAAKEWPEACYWGTDTSDSQLEGASVNIKAAGLDDKIELFKASVKALPLPSESFDAVISDIPFGKKFKITKDIQLLPDILQEMERVLRVGGIIVLLLNQDLRKRMDGIAKTVENESLNAIADGAGETTAVKALNNDGNSSSLGAGIEEPVLSCGQMRFGSLVPDGIYEVSLGKTDAFIYKYKKISTAGNK", "length": 494 }, "evidence": [ { "id": "E1B8U2", "url": "https://omabrowser.org/oma/group/E1B8U2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9BTF0-1", "protein_name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "gene_name": "THUMPD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQVEYISGKVFFTTCSDLNMLKKLKSAERLFLLIKKQFPLIISSVSKGKIFNEMQRLINEDPGSWLNAISIWKNLLELDAKKEKLSQRDDNQLKRKVGENEIIAKKLKIEQMQKIEENRDCQLEKQIKEETLEQRDFTTKSEKFQEEEFQNDIEKAIDTHNQNDLTFRVSCRCSGTIGKAFTAQEVGKVIGIAIMKHFGWKADLRNPQLEIFIHLNDIYSVVGIPVFRVSLASRAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDIKSILQEMERVLHVGGTIVLLLSEDHHRRLTDCKESNIPFNSKDSHTDEPGIKKCLNPEEKTGAFKTASTSFEASNHKFLDRMSPFGSLVPVECYKVSLGKTDAFICKYKKSHSSGL", "length": 503 }, "evidence": [ { "id": "E1B8U2", "url": "https://omabrowser.org/oma/group/E1B8U2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZB3-1", "protein_name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "gene_name": "Thumpd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVAQADPGSDPAGGARFFCTAGRGLEPFLMREVRARLEATQVEYISGKVFFTTCSDLPSMKKLKSAERLFVLIKKQLPIAVSSLHKGKILNEMQRFVNDDPGSWLEAISLWKKLLEHDPKREKVSQRDANPLKRKAGENETIIAKKLKVEEKQEVAKDHGESQEDKLLQGSPEQGEAVTRTELQDHRLNSTTEKAADAQDQEDLTFRVSCRCTGNVRKVITGQEAGRVIGLALMRQFGWKADLRNPNIEIFMHLSDAYSVVGIPLLRMPLASRTYIQTAGLRSTIAWAMASIAEIKAGALVLDPMCGLGTILVEAAEEWPDVFYMGADMSDAQLLGACDNLKAAGLTDRIELLKSSVTDLPLPSQSTDVIISDIPFGKKFKLGKDIKSILQEMERVLRVGGAMVLLLSEDHHRHLTDCGGSSIPLTSKGHIAEPEMKTLSNPDRTGAPDTASPSQRASSVQCLGRMRPCGSLVPVESFKVSLGKTDAFICKYKKAQASGLSSAECHEPGAHTEMAAMQESPSLQDSL", "length": 528 }, "evidence": [ { "id": "E1B8U2", "url": "https://omabrowser.org/oma/group/E1B8U2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "tRNA (guanine) methyltransferase activity", "id": "GO:0016423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016423", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "snRNA methyltransferase activity", "id": "GO:0106346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106346", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "U6 snRNA (guanine-N(2))-methyltransferase activity", "id": "GO:0160230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160230", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "RNA methyltransferase activity", "id": "GO:0008173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008173", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "tRNA methyltransferase complex", "id": "GO:0043527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043527", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "E1B8U2", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "83423", "name": "", "equation": "guanosine in U6 snRNA + S-adenosyl-L-methionine = N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B8U2-1" ], "evidence": [ { "id": "83423", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83423" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1B8U2", "gene_name": "THUMPD2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "E1B8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8U2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 501, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8U2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8U2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U2" }, { "id": "PRU00529", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00529" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THUMP", "eco_id": "ECO_0000255", "start_pos": 149, "end_pos": 264, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 199, "end_pos": 201 }, { "start_pos": 202, "end_pos": 204 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A8E4L3-1", "uniprot_ac": "A8E4L3", "uniprot_id": "CH082_BOVIN", "mass": { "chemical_mass": 24262.0, "monoisotopic_mass": 24262.0 }, "refseq": { "ac": "NP_001103654", "name": "UPF0598 protein C8orf82 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103654" }, "gene_names": [ { "name": "C14H8orf82", "type": "recommended", "evidence": [ { "id": "A8E4L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E4L3" } ] }, { "name": "C14H8orf82", "type": "synonym", "evidence": [ { "id": "NP_001103654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103654" } ] } ], "protein_names": [ { "name": "UPF0598 protein C8orf82 homolog", "type": "recommended", "evidence": [ { "id": "A8E4L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E4L3/entry#names_and_taxonomy" } ] }, { "name": "UPF0598 protein C8orf82 homolog", "type": "synonym", "evidence": [ { "id": "NP_001103654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103654" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8E4L3", "url": "https://www.uniprot.org/uniprotkb/A8E4L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A8E4L3", "locus": {} } ], "crossref": [ { "id": "A8E4L3", "url": "https://alphafold.ebi.ac.uk/entry/A8E4L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046031", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046031", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618766", "url": "https://www.ncbi.nlm.nih.gov/gene/618766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618766", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618766", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI14", "url": "https://www.orthodb.org/?gene=A0A452DI14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A8E4L3", "url": "https://www.orthodb.org/?gene=A8E4L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31449", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31449", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31449:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31449:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001103654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103654", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI14", "url": "https://www.uniprot.org/uniprotkb/A0A452DI14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI14-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8E4L3", "url": "https://www.uniprot.org/uniprotkb/A8E4L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8E4L3-1", "url": "https://www.uniprot.org/uniprotkb/A8E4L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWAMSGALRPWALILARSPGARTYAGGGGVSYTQGQSPEPRTREYFYYVDHQGQLFLDDSRMKNFTTCFKDPQFLVMFFSRLRPNRSGRYEAYFPFLSLCGRERNFLRCEDRPVVFTHLLAAGPAPQRLSYCGGGEALAVPFEPARLLPLATNGRLYHPAPERAGGVGLVRSALAFELSACFEYAPGAPELPSHVRWQGRRFALTMDLAPLLLAAPPP", "length": 218, "header": "sp|A8E4L3-1|CH082_BOVIN Isoform 1 of UPF0598 protein C8orf82 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A8E4L3-1" }, "isoforms": [ { "isoform_ac": "A0A452DI14-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI14/entry", "sequence": { "sequence": "MKTLCANKVRMDTSESVASHSFQWQRGSYQQPVAGVGTRVDLFLDDSRMKNFTTCFKDPQFLVMFFSRLRPNRSGRYEAYFPFLSLCGRERNFLRCEDRPVVFTHLLAAGPAPQRLSYCGGGEALAVPFEPARLLPLATNGRLYHPAPERAGGVGLVRSALAFELSACFEYAPGAPELPSHVRWQGRRFALTMDLAPLLLAAPPP", "length": 205, "header": "tr|A0A452DI14-1|CH082_BOVIN Computationally mapped isoform of UPF0598 protein C8orf82 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A8E4L3-1" }, "locus": { "chromosome": "14", "start_pos": 418386, "end_pos": 416135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006544.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006544.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006544.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006544.6" } ] } }, { "isoform_ac": "A0AAA9SL85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL85/entry", "sequence": { "sequence": "MWAMSGALRPWALILARSPGARTYAGGGGVSYTQGQSPEPRTREYFYYVDHQGQLFLDDSRMKNFTTCFKGTDAPSTPSLFLRERLL", "length": 87, "header": "tr|A0AAA9SL85-1|CH082_BOVIN Computationally mapped isoform of UPF0598 protein C8orf82 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A8E4L3-1" }, "locus": { "chromosome": "14", "start_pos": 417718, "end_pos": 416921, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105147.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105147.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084668.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084668.1" } ] } }, { "isoform_ac": "A0AAA9SYZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ7/entry", "sequence": { "sequence": "MTSGRFRRRRRMWAMSGALRPWALILARSPGARTYAGGGGVSYTQGQSPEPRTREYFYYVDHQGQVGGGGVFTVRQPGLPGRAGNTRTRGYGPKGLGPQRTTSRAWLRPAGFASPGPASPAAAPDLEALAVASTIHTRKQLREPMRKKWHISLETKREEGRGAERACQLRESVLEELFLDDSRMKNFTTCFKDPQFLVMFFSRLRPNRSGRYEAYFPFLSLCGRERNFLRCEDRPVVFTHLLAAGPAPQRLSYCGGGEALAVPFEPARLLPLATNGRLYHPAPERAGGVGLVRSALAFELSACFEYAPGAPELPSHVRWQGRRFALTMDLAPLLLAAPPP", "length": 340, "header": "tr|A0AAA9SYZ7-1|CH082_BOVIN Computationally mapped isoform of UPF0598 protein C8orf82 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A8E4L3-1" }, "locus": { "chromosome": "14", "start_pos": 418386, "end_pos": 416888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089084.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089084.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088598.1" } ] } }, { "isoform_ac": "A8E4L3-1", "url": "https://www.uniprot.org/uniprotkb/A8E4L3/entry#A8E4L3-1", "sequence": { "sequence": "MWAMSGALRPWALILARSPGARTYAGGGGVSYTQGQSPEPRTREYFYYVDHQGQLFLDDSRMKNFTTCFKDPQFLVMFFSRLRPNRSGRYEAYFPFLSLCGRERNFLRCEDRPVVFTHLLAAGPAPQRLSYCGGGEALAVPFEPARLLPLATNGRLYHPAPERAGGVGLVRSALAFELSACFEYAPGAPELPSHVRWQGRRFALTMDLAPLLLAAPPP", "length": 218, "header": "sp|A8E4L3-1|CH082_BOVIN Isoform 1 of UPF0598 protein C8orf82 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A8E4L3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618766", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618766", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A8E4L3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A8E4L3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A8E4L3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 64, "end_pos": 66 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6H7I7-1", "uniprot_ac": "A6H7I7", "uniprot_id": "F110D_BOVIN", "mass": { "chemical_mass": 28738.0, "monoisotopic_mass": 28738.0 }, "refseq": { "ac": "NP_001092673", "name": "protein FAM110D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673" }, "gene_names": [ { "name": "FAM110D", "type": "recommended", "evidence": [ { "id": "A6H7I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I7" } ] }, { "name": "FAM110D", "type": "synonym", "evidence": [ { "id": "NP_001092673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673" } ] }, { "name": "GRRP1", "type": "synonym", "evidence": [ { "id": "NP_001092673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673" }, { "id": "A6H7I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I7" } ] } ], "protein_names": [ { "name": "Protein FAM110D", "type": "recommended", "evidence": [ { "id": "A6H7I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I7/entry#names_and_taxonomy" } ] }, { "name": "Glycine/arginine-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001092673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673" } ] }, { "name": "glycine/arginine rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001092673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673" } ] }, { "name": "protein FAM110D", "type": "synonym", "evidence": [ { "id": "NP_001092673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6H7I7", "url": "https://www.uniprot.org/uniprotkb/A6H7I7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM110D", "url": "https://www.uniprot.org/uniprotkb/A6H7I7", "locus": { "chromosome": "2", "start_pos": 126935591, "end_pos": 126939832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013131", "url": "https://www.ensembl.org/id/ENSBTAG00000013131" } ] } } ], "crossref": [ { "id": "A6H7I7", "url": "https://alphafold.ebi.ac.uk/entry/A6H7I7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013131", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013131", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "787384", "url": "https://www.ncbi.nlm.nih.gov/gene/787384", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787384", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787384", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGCQRAW", "url": "https://omabrowser.org/oma/group/YGCQRAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIM8", "url": "https://www.orthodb.org/?gene=A0A452DIM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6H7I7", "url": "https://www.orthodb.org/?gene=A6H7I7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14758", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14758", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14758:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14758:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIM8", "url": "https://www.uniprot.org/uniprotkb/A0A452DIM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H7I7", "url": "https://www.uniprot.org/uniprotkb/A6H7I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H7I7-1", "url": "https://www.uniprot.org/uniprotkb/A6H7I7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLASPSTPSRGRTPSAVERLEADKAKYVKTHQVIARRQEPALRGGPGPLTPHTCNELGPPPSPRTPRPARRGSGRRLPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGSPRDVASSSAGSSERPAAPGGWTAPQDAPEAAGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGADASPQPGTSPPPGSGDASDWTSSEGGADRRDGAEGGGSAAAGSERDGRPQVSVVERNARVIQWLYGCQRARGPPRESEV", "length": 270, "header": "sp|A6H7I7-1|F110D_BOVIN Isoform 1 of Protein FAM110D OS=Bos taurus OX=9913 GN=FAM110D PE=2 SV=1 CANONICAL=A6H7I7-1" }, "isoforms": [ { "isoform_ac": "A0A452DIM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIM8/entry", "sequence": { "sequence": "MQRSQGAPANCSQFLHYLPASSGLWSTVLPSSAKMLLASPSTPSRGRTPSAVERLEADKAKYVKTHQVIARRQEPALRGGPGPLTPHTCNELGPPPSPRTPRPARRGSGRRLPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGSPRDVASSSAGSSERPAAPGGWTAPQDAPEAAGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGADASPQPGTSPPPGSGDASDWTSSEGGADRRDGAEGGGSAAAGSERDGRPQVSVVERNARVIQWLYGCQRARGPPRESEV", "length": 304, "header": "tr|A0A452DIM8-1|F110D_BOVIN Computationally mapped isoform of Protein FAM110D OS=Bos taurus OX=9913 GN=FAM110D PE=2 SV=1 CANONICAL=A6H7I7-1" }, "locus": { "chromosome": "2", "start_pos": 126939754, "end_pos": 126937058, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017456.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017456.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017456.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017456.6" } ] } }, { "isoform_ac": "A6H7I7-1", "url": "https://www.uniprot.org/uniprotkb/A6H7I7/entry#A6H7I7-1", "sequence": { "sequence": "MLLASPSTPSRGRTPSAVERLEADKAKYVKTHQVIARRQEPALRGGPGPLTPHTCNELGPPPSPRTPRPARRGSGRRLPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGSPRDVASSSAGSSERPAAPGGWTAPQDAPEAAGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGADASPQPGTSPPPGSGDASDWTSSEGGADRRDGAEGGGSAAAGSERDGRPQVSVVERNARVIQWLYGCQRARGPPRESEV", "length": 270, "header": "sp|A6H7I7-1|F110D_BOVIN Isoform 1 of Protein FAM110D OS=Bos taurus OX=9913 GN=FAM110D PE=2 SV=1 CANONICAL=A6H7I7-1" }, "locus": { "chromosome": "2", "start_pos": 126937867, "end_pos": 126937058, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095511.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095511.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076641.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 8, "start_aa": "Thr", "end_pos": 8, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:787384", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787384", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZKU0-1", "protein_name": "Family with sequence similarity 110 member D", "gene_name": "FAM110D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQRPQGAPANCSQLLNHLPTSSGLWGTVLPSSSKMLLASPSTPARGRTPSAVERLEADKAKYVKTHQVIARRQEPALRGAPGPLTPHPCNELGPPPSPRTPRSARRGSGRRLPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGSPRDVASSSPGSTERPAAPGGWVAPQEAPETAGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGADASPQPGTSPLPGSGDTSDWTSSDGGADRRDCAEGGGSEAADSTRDGRPQVSVVERNARVIQWLYGCQRARGPPRESEV", "length": 304 }, "evidence": [ { "id": "A6H7I7", "url": "https://omabrowser.org/oma/group/A6H7I7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YXH8-1", "protein_name": "Family with sequence similarity 110 member D", "gene_name": "FAM110D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSPPGRGEGRGKNNPWAGSVPCGFLQFTALPEGRGGRNLPGSELTLTLSPLTEGAGRTLLCPIPVGSGRTPRKGITVPGSCGSELSLLLAAGGNRSRGDRPALCAGPGPWLSAAAEHSFGVPIPHRVGRRAMVPLGSTPRAVCTSGRDVSPLRLLNRGPESLRAQLAGGSGGRTPSAVERLEADKVKYVKSQQVINSRQEPALRGCSPCCSPRGRRLLALQRCHELCHGSDLSCDGSRKAPCPSSPVPRRGGGSRRLLRPDSLVIYRQKRDCPVINKENTKGYGLVRRLFQGPLRDKPPSSPSAQGSDKAPESPMLWVSMEQAEDVRTPGAGGSSSSTVPMPDSPVPQPPEAPSLAQPPASPSPSKPALGLRLSLPLSEKERFFNYCGLDRAMVEGLGKERFVPAGWDAASARLHGSCEWEPSQASGCSGEDAGPGEEEPDTRLCSAISVVERNARVIKWLYGCQRAWAAAKESTV", "length": 477 }, "evidence": [ { "id": "A6H7I7", "url": "https://omabrowser.org/oma/group/A6H7I7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZKX3-1", "protein_name": "Family with sequence similarity 110, member D", "gene_name": "Fam110d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLASPTTPSRGRTPSAVERLEADKAKYVKTHQVIVRRQEPALRGGSGPLTPHPCNELGASASPRTPGPARRGSGRRQPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGATRDAAPSSPAPTERPGAPAGWAGSPDTPEATGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGAEHSPQVATSPPPGSGDTSDWTSSDRDAGSPDCAGGGGGSEAAGSARDGRPTVSVVERNARVIQWLYGCQRARAPPRESEV", "length": 271 }, "evidence": [ { "id": "A6H7I7", "url": "https://omabrowser.org/oma/group/A6H7I7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80X91-1", "protein_name": "Protein FAM110D", "gene_name": "Fam110d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLSSPTTPSRGRTPSAVERLEADKAKYVKTHQVIVRRQEPALRGGPGPLTPHPCNELGASASPRTPGPARRGSGRRQPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGATRDAAPSSPAPTERPGAPAGWAGSPDTPEATGKRAVCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGAEHGPQVATSPPPGSGDTSDWTSSDRDAGSPDCAGGGGGSEAAGSARDGRPTVSVVERNARVIQWLYGCQRARAPPRESEV", "length": 271 }, "evidence": [ { "id": "A6H7I7", "url": "https://omabrowser.org/oma/group/A6H7I7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TAY7-1", "protein_name": "Protein FAM110D", "gene_name": "FAM110D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLAPPSTPSRGRTPSAVERLEADKAKYVKTHQVIARRQEPALRGSPGPLTPHPCNELGPPASPRTPRPVRRGSGRRLPRPDSLIFYRQKRDCKASVNKENAKGQGLVRRLFLGAPRDAAPSSPASTERPAASGGWAAPQDAPEAAGKRALCPTCSLPLSEKERFFNYCGLERALVEVLGAERFSPQSWGADASPQAGTSPPPGSGDASDWTSSDRGVDSPGGAGGGGGSEAAGSARDRRPPVSVVERNARVIQWLYGCQRARGPPRESEV", "length": 271 }, "evidence": [ { "id": "A6H7I7", "url": "https://omabrowser.org/oma/group/A6H7I7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6H7I7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 270, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6H7I7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6H7I7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 8 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AHM4-1", "uniprot_ac": "A0AAF7AHM4", "uniprot_id": "A0AAF7AHM4_BOVIN", "mass": { "chemical_mass": 76038.0, "monoisotopic_mass": 76038.0 }, "refseq": {}, "gene_names": [ { "name": "BCNT2", "type": "recommended", "evidence": [ { "id": "A0AAF7AHM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4" } ] } ], "protein_names": [ { "name": "Bucentaur-2", "type": "synonym", "evidence": [ { "id": "A0AAF7AHM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCNT2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4", "locus": { "chromosome": "18", "start_pos": 2763275, "end_pos": 2799656, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030600", "url": "https://www.ensembl.org/id/ENSBTAG00000030600" } ] } } ], "crossref": [ { "id": "A0AAF7AHM4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AHM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009805", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009805", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000015427", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015427", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09076", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09076", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIN9", "url": "https://www.orthodb.org/?gene=A0A452DIN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MS40", "url": "https://www.orthodb.org/?gene=F1MS40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23227", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23227", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23227:SF85", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23227:SF85", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A452DIN9", "url": "https://www.uniprot.org/uniprotkb/A0A452DIN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIN9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AHM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AHM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS40", "url": "https://www.uniprot.org/uniprotkb/F1MS40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS40-1", "url": "https://www.uniprot.org/uniprotkb/F1MS40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEFKSEDFSVSKEDEDYAPSGGECHEDAVNELVKEGEMGAEEETQKTKGTKRKAESILARKRKHSGLSPQHEEEEDANRESGGSISEKEDVAAEQEKGAESEDAREEEEEEMLASSIGDVEPKSEVPPSTQVKTGEENKEMASSKVVKTEEQEKPKEPEEVKVTKVFDIAGEKVRFLRRQGRPGMSPEHEPPRSEGGQHATGEEQRSVTNTSSKNESTKRKWKRRANVVVTGEESKLRCCKEEYCIGTWNVRSMNPGKLDVVKQEMERINIDILGISELKWTGMGELNSDDHYIYYCGQQSLRRNGVAIIVNKRVRNAVIGCNLKNDRMISVRFQGKPFNLTVIQVYAPTPYAPEPEVYRFYEDLQHLLEITPKIDVLFIIGDWNAKVGSQEIPRITGKFGLGVQNEAGRRLIEFCYQNRLVIANTLFQQHKRRLYTWTSPDGRYRDQIDYIICRQRWRSSVQSAKTRPGADCGSDHKLLIAKFRLKLKIIPKTTRPFRGTNEVGETSQEAKSVFKQTEKGKPQANVPSNVSSVPGGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGTEAEALVLWSPDVKRGLLGKDPDAGKARRQLEEGTVEHEMVAWHHQLSGREFEQTRGDDE", "length": 680, "header": "tr|A0AAF7AHM4-1|A0AAF7AHM4_BOVIN Isoform 1 of Bucentaur-2 OS=Bos taurus OX=9913 GN=BCNT2 PE=1 SV=1 CANONICAL=A0AAF7AHM4-1" }, "isoforms": [ { "isoform_ac": "A0A452DIN9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIN9/entry", "sequence": { "sequence": "MEEFKSEDFSVSKEDEDYAPSGGECHEDAVNELVKEGEMGAEEETQKTKGTKRKAESILARKRKHSGLSPQHEEEEDANRESGGSISEKEDVAAEQEKGAESEDAREEEEEEMLASSIGDVEPKSEVPPSTQVKTGEENKEMASSKVVKTEEQEKPKEPEEVKVTKVFDIAGEKVRFLRRQGRPGMSPEHEPPRSEGGQHATGEEQRSVTNTSSKNESTKRKWKRRANVVVTGEESKLRCCKEEYCIGTWNVRSMNPGKLDVVKQEMERINIDILGISELKWTGMGELNSDDHYIYYCGQQSLRRNGVAIIVNKRVRNAVIGCNLKNDRMISVRFQGKPFNLTVIQVYAPTPYAPEPEVYRFYEDLQHLLEITPKIDVLFIIGDWNAKVGSQEIPRITGKFGLGVQNEAGRRLIEFCYQNRLVIANTLFQQHKRRLYTWTSPDGRYRDQIDYIICRQRWRSSVQSAKTRPGADCGSDHKLLIAKFRLKLKIIPKTTRPFRGTNEVGETSQEAKSVFKQTEKGKPQANVPSNVSSVPGGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGPGSKRHCVHWCAVTPATEV", "length": 639, "header": "tr|A0A452DIN9-1|A0AAF7AHM4_BOVIN Computationally mapped isoform of Bucentaur-2 OS=Bos taurus OX=9913 GN=BCNT2 PE=1 SV=2 CANONICAL=A0AAF7AHM4-1" }, "locus": { "chromosome": "18", "start_pos": 2799457, "end_pos": 2767411, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020504.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020504.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020504.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020504.6" } ] } }, { "isoform_ac": "A0AAF7AHM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4/entry", "sequence": { "sequence": "MEEFKSEDFSVSKEDEDYAPSGGECHEDAVNELVKEGEMGAEEETQKTKGTKRKAESILARKRKHSGLSPQHEEEEDANRESGGSISEKEDVAAEQEKGAESEDAREEEEEEMLASSIGDVEPKSEVPPSTQVKTGEENKEMASSKVVKTEEQEKPKEPEEVKVTKVFDIAGEKVRFLRRQGRPGMSPEHEPPRSEGGQHATGEEQRSVTNTSSKNESTKRKWKRRANVVVTGEESKLRCCKEEYCIGTWNVRSMNPGKLDVVKQEMERINIDILGISELKWTGMGELNSDDHYIYYCGQQSLRRNGVAIIVNKRVRNAVIGCNLKNDRMISVRFQGKPFNLTVIQVYAPTPYAPEPEVYRFYEDLQHLLEITPKIDVLFIIGDWNAKVGSQEIPRITGKFGLGVQNEAGRRLIEFCYQNRLVIANTLFQQHKRRLYTWTSPDGRYRDQIDYIICRQRWRSSVQSAKTRPGADCGSDHKLLIAKFRLKLKIIPKTTRPFRGTNEVGETSQEAKSVFKQTEKGKPQANVPSNVSSVPGGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGTEAEALVLWSPDVKRGLLGKDPDAGKARRQLEEGTVEHEMVAWHHQLSGREFEQTRGDDE", "length": 680, "header": "tr|A0AAF7AHM4-1|A0AAF7AHM4_BOVIN Isoform 1 of Bucentaur-2 OS=Bos taurus OX=9913 GN=BCNT2 PE=1 SV=1 CANONICAL=A0AAF7AHM4-1" }, "locus": { "chromosome": "18", "start_pos": 2799457, "end_pos": 2765577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072376.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072376.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069228.2" } ] } }, { "isoform_ac": "F1MS40-1", "url": "https://www.uniprot.org/uniprotkb/F1MS40/entry", "sequence": { "sequence": "MEEFKSEDFSVSKEDEDYAPSGGECHEDAVNELVKEGEMGAEEETQKTKGTKRKAESILARKRKHSGLSPQHEEEEDANRESGGSISEKEDVAAEQEKGAESEDAREEEEEEMLASSIGDVEPKSEVPPSTQVKTGEENKEMASSKVVKTEEQEKPKEPEEVKVTKVFDIAGEKVRFLRRQGRPGMSPEHEPPRSEGGQHATGEEQRSVTNTSSKNESTKRKWKRRANVVVTGEESKLRCCKEEYCIGTWNVRSMNPGKLDVVKQEMERINIDILGISELKWTGMGELNSDDHYIYYCGQQSLRRNGVAIIVNKRVRNAVIGCNLKNDRMISVRFQGKPFNLTVIQVYAPTPYAPEPEVYRFYEDLQHLLEITPKIDVLFIIGDWNAKVGSQEIPRITGKFGLGVQNEAGRRLIEFCYQNRLVIANTLFQQHKRRLYTWTSPDGRYRDQIDYIICRQRWRSSVQSAKTRPGADCGSDHKLLIAKFRLKLKIIPKTTRPFRGTNEVGETSQEAKSVFKQTEKGKPQANVPSNVSSVPGGSGVSKEVGETSQEGKSVFKQNEKEEPQSSVPSAVPSLPAGSGPENCDLEKNQDCSN", "length": 594, "header": "tr|F1MS40-1|A0AAF7AHM4_BOVIN Computationally mapped isoform of Bucentaur-2 OS=Bos taurus OX=9913 GN=BCNT2 PE=1 SV=3 CANONICAL=A0AAF7AHM4-1" }, "locus": { "chromosome": "18", "start_pos": 2799457, "end_pos": 2763310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132947.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132947.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082713.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHM4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 531, "end_pos": 533, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AHM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHM4" }, { "id": "PF03372", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Endonuclease/exonuclease/phosphatase", "eco_id": "ECO_0000259", "start_pos": 248, "end_pos": 478, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 211, "end_pos": 213 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 531, "end_pos": 533 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A5D7J1-1", "uniprot_ac": "A5D7J1", "uniprot_id": "LYRM9_BOVIN", "mass": { "chemical_mass": 9302.0, "monoisotopic_mass": 9302.0 }, "refseq": { "ac": "NP_001181958", "name": "LYR motif-containing protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958" }, "gene_names": [ { "name": "LYRM9", "type": "recommended", "evidence": [ { "id": "A5D7J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J1" } ] }, { "name": "C19H17orf108", "type": "synonym", "evidence": [ { "id": "NP_001181958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958" } ] }, { "name": "LYRM9", "type": "synonym", "evidence": [ { "id": "NP_001181958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958" } ] } ], "protein_names": [ { "name": "LYR motif-containing protein 9", "type": "recommended", "evidence": [ { "id": "A5D7J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J1/entry#names_and_taxonomy" } ] }, { "name": "LYR motif-containing protein 9", "type": "synonym", "evidence": [ { "id": "NP_001181958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958" } ] }, { "name": "UPF0631 protein C17orf108 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958" } ] }, { "name": "UPF0631 protein HSD24 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A5D7J1", "url": "https://www.uniprot.org/uniprotkb/A5D7J1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYRM9", "url": "https://www.uniprot.org/uniprotkb/A5D7J1", "locus": { "chromosome": "19", "start_pos": 19487741, "end_pos": 19503201, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033298", "url": "https://www.ensembl.org/id/ENSBTAG00000033298" } ] } } ], "crossref": [ { "id": "A5D7J1", "url": "https://alphafold.ebi.ac.uk/entry/A5D7J1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033298", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615250", "url": "https://www.ncbi.nlm.nih.gov/gene/615250", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615250", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615250", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A5D7J1", "url": "https://www.orthodb.org/?gene=A5D7J1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47061", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47061", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47061:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47061:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181958", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJF5", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJF5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A5D7J1", "url": "https://www.uniprot.org/uniprotkb/A5D7J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A5D7J1-1", "url": "https://www.uniprot.org/uniprotkb/A5D7J1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPLPGAELVQTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNKYKKQN", "length": 78, "header": "sp|A5D7J1-1|LYRM9_BOVIN Isoform 1 of LYR motif-containing protein 9 OS=Bos taurus OX=9913 GN=LYRM9 PE=3 SV=1 CANONICAL=A5D7J1-1" }, "isoforms": [ { "isoform_ac": "A0A452DJF5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF5/entry", "sequence": { "sequence": "MQGLLTCCQSPEERPQDTAVPPTFVLVGLLGDEPSAGLMPSLSSGARFHGDQASIHTGSNTPASQSARSWGPGQSIGCMPRSDAVHFPGTEVWRMAPLPGAELVQTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNKYKKQN", "length": 172, "header": "tr|A0A452DJF5-1|LYRM9_BOVIN Computationally mapped isoform of LYR motif-containing protein 9 OS=Bos taurus OX=9913 GN=LYRM9 PE=3 SV=1 CANONICAL=A5D7J1-1" }, "locus": {} }, { "isoform_ac": "A0AAA9SZV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZV7/entry", "sequence": { "sequence": "MAPLPGAELVQTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNKLRLIPAPDQQLPSSRRP", "length": 90, "header": "tr|A0AAA9SZV7-1|LYRM9_BOVIN Computationally mapped isoform of LYR motif-containing protein 9 OS=Bos taurus OX=9913 GN=LYRM9 PE=3 SV=1 CANONICAL=A5D7J1-1" }, "locus": { "chromosome": "19", "start_pos": 19492782, "end_pos": 19490753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110708.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110708.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089656.1" } ] } }, { "isoform_ac": "A0AAA9TF83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF83/entry", "sequence": { "sequence": "MAPLPGAELVQTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNKVSPWLVSTLKLG", "length": 85, "header": "tr|A0AAA9TF83-1|LYRM9_BOVIN Computationally mapped isoform of LYR motif-containing protein 9 OS=Bos taurus OX=9913 GN=LYRM9 PE=3 SV=1 CANONICAL=A5D7J1-1" }, "locus": { "chromosome": "19", "start_pos": 19492782, "end_pos": 19490866, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088643.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088643.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095655.1" } ] } }, { "isoform_ac": "A5D7J1-1", "url": "https://www.uniprot.org/uniprotkb/A5D7J1/entry#A5D7J1-1", "sequence": { "sequence": "MAPLPGAELVQTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNKYKKQN", "length": 78, "header": "sp|A5D7J1-1|LYRM9_BOVIN Isoform 1 of LYR motif-containing protein 9 OS=Bos taurus OX=9913 GN=LYRM9 PE=3 SV=1 CANONICAL=A5D7J1-1" }, "locus": { "chromosome": "19", "start_pos": 19492782, "end_pos": 19489995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055200.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055200.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048935.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048935.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615250", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615250", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A5D7J1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 78, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A5D7J1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A5D7J1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB63-1", "uniprot_ac": "E1BB63", "uniprot_id": "E1BB63_BOVIN", "mass": { "chemical_mass": 67327.0, "monoisotopic_mass": 67327.0 }, "refseq": {}, "gene_names": [ { "name": "CLEC4F", "type": "recommended", "evidence": [ { "id": "E1BB63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB63" } ] } ], "protein_names": [ { "name": "C-type lectin domain family 4 member F", "type": "synonym", "evidence": [ { "id": "E1BB63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB63/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB63", "url": "https://www.uniprot.org/uniprotkb/E1BB63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC4F", "url": "https://www.uniprot.org/uniprotkb/E1BB63", "locus": { "chromosome": "11", "start_pos": 13585192, "end_pos": 13568334, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004560", "url": "https://www.ensembl.org/id/ENSBTAG00000004560" } ] } } ], "crossref": [ { "id": "E1BB63", "url": "https://alphafold.ebi.ac.uk/entry/E1BB63", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004560", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BB63", "url": "https://www.orthodb.org/?gene=E1BB63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RVQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB63", "url": "https://www.uniprot.org/uniprotkb/E1BB63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB63-1", "url": "https://www.uniprot.org/uniprotkb/E1BB63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQMWFKKLHFPTAGSQRGRELFWRMKEAETRADQVHFCTENQNVSLSSQGLDPVAVVPAAPRMPRRLQATLASLGVFLVSCLVVLFIVDPYHSVRVAEFQEAVQLFKGHMENSSTWSVEIQLLTCRVDNVSSQIQMLGGDLESASADIQMLKGLLKDASALSFQTQLLRSSLEETTSKIQKLQGDLEEANGSNSQIQGSFKSSLENTSIELLVLSRGLENANTEIQVLKAGLETANAEVRLANSSLKNVNAQIHVLRGDLDSVSDLRAHHQVLRSSLESTTAEMQRLKGSLQNANALNSQTQTFVRGSLDNTSAQIQVLRSHLERAGGEIHLLKRDLENVTAQTQTASSHLEQTDAEMRVLKTELESAIALSSKIQVLNGLLRNASQEIQTLKQGMKDAAALQSQTQMLERSLQEARTEIQTLRKDLGNTKTLRTTIQEQQRSLESFRTALASQEQLQRNHNQLFQLFLQGWKFYSGSLYYFSSAKKTWQEAEQFCVSHGAHLASVTSEEEKTFLIQFTSSVYHWIGLTDHGTEGHWRWTDGTAFDRARSRAFWAENQPDNWQHGIGQSEDCVQMQQKWNDISCSTLCRWICKKPMVQL", "length": 599, "header": "tr|E1BB63-1|E1BB63_BOVIN Isoform 1 of C-type lectin domain family 4 member F OS=Bos taurus OX=9913 GN=CLEC4F PE=4 SV=4 CANONICAL=E1BB63-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVQ7/entry", "sequence": { "sequence": "MKEAETRADQVHFCTENQNVSLSSQGLDPVAVVPAAPRMPRRLQATLASLGVFLVSCLVVLFIVEFLGDNHTGQFLKERDYPYHSVRVAEFQEAVQLFKGHMENSSTWSVEIQLLTCRVDNVSSQIQMLGGDLESASADIQMLKGLLKDASALSFQTQLLRSSLEETTSKIQKLQGDLEEANGSNSQIQGSFKSSLENTSIELLVLSRGLENANTEIQVLKAGLETANAEVRLANSSLKNVNAQIHVLRGDLDSVSDLRAHHQVLRSSLESTTAEMQRLKGSLQNANALNSQTQTFVRGSLDNTSAQIQVLRSHLERAGGEIHLLKRDLENVTAQTQTASSHLEQTDAEMRVLKTELESAIALSSKIQVLNGLLRNASQEIQTLKQGMKDAAALQSQTQMLERSLQEARTEIQTLRKDLGNTKTLRTTIQEQQRSLESFRTALASQEQLQRNHNQLFQLFLQGWKFYSGSLYYFSSAKKTWQEAEQFCVSHGAHLASVTSEEEKTFLIQFTSSVYHWIGLTDHGTEGHWRWTDGTAFDRARSRAFWAENQPDNWQHGIGQSEDCVQMQQKWNDISCSTLCRWICKKPMVQL", "length": 591, "header": "tr|A0AAA9RVQ7-1|E1BB63_BOVIN Computationally mapped isoform of C-type lectin domain family 4 member F OS=Bos taurus OX=9913 GN=CLEC4F PE=4 SV=2 CANONICAL=E1BB63-1" }, "locus": { "chromosome": "11", "start_pos": 13584188, "end_pos": 13572498, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110598.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110598.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076426.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076426.2" } ] } }, { "isoform_ac": "E1BB63-1", "url": "https://www.uniprot.org/uniprotkb/E1BB63/entry", "sequence": { "sequence": "MQMWFKKLHFPTAGSQRGRELFWRMKEAETRADQVHFCTENQNVSLSSQGLDPVAVVPAAPRMPRRLQATLASLGVFLVSCLVVLFIVDPYHSVRVAEFQEAVQLFKGHMENSSTWSVEIQLLTCRVDNVSSQIQMLGGDLESASADIQMLKGLLKDASALSFQTQLLRSSLEETTSKIQKLQGDLEEANGSNSQIQGSFKSSLENTSIELLVLSRGLENANTEIQVLKAGLETANAEVRLANSSLKNVNAQIHVLRGDLDSVSDLRAHHQVLRSSLESTTAEMQRLKGSLQNANALNSQTQTFVRGSLDNTSAQIQVLRSHLERAGGEIHLLKRDLENVTAQTQTASSHLEQTDAEMRVLKTELESAIALSSKIQVLNGLLRNASQEIQTLKQGMKDAAALQSQTQMLERSLQEARTEIQTLRKDLGNTKTLRTTIQEQQRSLESFRTALASQEQLQRNHNQLFQLFLQGWKFYSGSLYYFSSAKKTWQEAEQFCVSHGAHLASVTSEEEKTFLIQFTSSVYHWIGLTDHGTEGHWRWTDGTAFDRARSRAFWAENQPDNWQHGIGQSEDCVQMQQKWNDISCSTLCRWICKKPMVQL", "length": 599, "header": "tr|E1BB63-1|E1BB63_BOVIN Isoform 1 of C-type lectin domain family 4 member F OS=Bos taurus OX=9913 GN=CLEC4F PE=4 SV=4 CANONICAL=E1BB63-1" }, "locus": { "chromosome": "11", "start_pos": 13584188, "end_pos": 13571917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005991.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005991.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005991.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005991.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BB63", "url": "https://www.uniprot.org/uniprotkb/E1BB63" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "E1BB63", "url": "https://www.uniprot.org/uniprotkb/E1BB63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "E1BB63", "url": "https://www.uniprot.org/uniprotkb/E1BB63" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BB63", "url": "https://www.uniprot.org/uniprotkb/E1BB63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB63" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 475, "end_pos": 593, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9U5-1", "uniprot_ac": "E1B9U5", "uniprot_id": "E1B9U5_BOVIN", "mass": { "chemical_mass": 67389.0, "monoisotopic_mass": 67389.0 }, "refseq": { "ac": "NP_001178212", "name": "fucose-1-phosphate guanylyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178212" }, "gene_names": [ { "name": "FPGT", "type": "recommended", "evidence": [ { "id": "E1B9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ] }, { "name": "FPGT", "type": "synonym", "evidence": [ { "id": "NP_001178212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178212" } ] } ], "protein_names": [ { "name": "Fucose-1-phosphate guanylyltransferase", "type": "synonym", "evidence": [ { "id": "E1B9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U5/entry#names_and_taxonomy" } ] }, { "name": "fucose-1-phosphate guanylyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001178212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178212" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FPGT", "url": "https://www.uniprot.org/uniprotkb/E1B9U5", "locus": { "chromosome": "3", "start_pos": 70600177, "end_pos": 70608484, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038480", "url": "https://www.ensembl.org/id/ENSBTAG00000038480" } ] } } ], "crossref": [ { "id": "E1B9U5", "url": "https://alphafold.ebi.ac.uk/entry/E1B9U5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038480", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038480", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138313", "url": "https://www.ncbi.nlm.nih.gov/gene/100138313", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138313", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138313", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DMIAYRE", "url": "https://omabrowser.org/oma/group/DMIAYRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9U5", "url": "https://www.orthodb.org/?gene=E1B9U5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15045", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15045", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15045:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15045:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07959", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07959", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6787639", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6787639", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178212", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAESAPAGESLREATQRRLLRFSELRGKSMAAGEFWDIVAITAADEKQELAYKQQLSEKLKKKELPLGVQYHVFVDPAGAKIGNGGSTLCALRCLEKLYGDKWNSFTILLIHSGGYSQRLPSASALGKIFTALPFGSPIYQMLELKLAMYIDFPSHMNPGILITCADDIELYSIGESEFIRFDKPGFTALAHPSSLTVGTTHGVFVLEPCNHLEYRDLEYRSCHRFLHKPSVEEMYEFDAVCRPRNFFQQEFAGSDIPSLKLEPEYVYTDSLFYMDHKTAKKLLAFYEKIGTLHCEIDAYGDFLQALGPGATVEYTKNTSNVTKEESELVDMRQRIFHLLKGTPLNVVVLNNSKFYHIGTTEEYLFHFTADSSLKSELGLQSIAFSLFPSIPECSTNKPCIIQSILDSTCSVTPGSVVEYSRLGPDVSVEENCIISGAYVKTTAVLPAYSFVCSLSLKMNGHLKYSTMACGVQDNLKKNVKTLSDVKLLQFFGVCFLSCLDIWNLKVTEELFSGNKTCLSLWNARIFPVCSSLSDSVTTSLKMLNAVQSKSAFSLNNYKLLSIEEMLFYKDIEDMITYREQIFLEITLNRKQSDLETSY", "length": 600, "header": "tr|E1B9U5-1|E1B9U5_BOVIN Isoform 1 of Fucose-1-phosphate guanylyltransferase OS=Bos taurus OX=9913 GN=FPGT PE=4 SV=2 CANONICAL=E1B9U5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ4/entry", "sequence": { "sequence": "MEAESAPAGESLREATQRRLLRFSELRGKSMAAGEFWDIVAITAADEKQELAYKQQLSEKLKKKELPLGVQYHVFVDPAGAKIGMFMAMEDQPFVPFDVWKSFMEINGILLPSY", "length": 114, "header": "tr|A0AAA9RWQ4-1|E1B9U5_BOVIN Computationally mapped isoform of Fucose-1-phosphate guanylyltransferase OS=Bos taurus OX=9913 GN=FPGT PE=4 SV=1 CANONICAL=E1B9U5-1" }, "locus": { "chromosome": "3", "start_pos": 70608293, "end_pos": 70605290, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133427.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133427.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077873.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077873.1" } ] } }, { "isoform_ac": "A0AAA9T9K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K6/entry", "sequence": { "sequence": "MEAESAPAGESLREATQRRLLRFSELRGKSMAAGEFWDIVAITAADEKQELAYKQQLSEKLKKKELPLGVQYHVFVDPAGAKIGGYSQRLPSASALGKIFTALPFGSPIYQMLELKLAMYIDFPSHMNPGILITCADDIELYSIGESEFIRFDKPGFTALAHPSSLTVGTTHGVFVLEPCNHLEYRDLEYRSCHRFLHKPSVEEMYEFDAVCRPRNFFQQEFAGSDIPSLKLEPEYVYTDSLFYMDHKTAKKLLAFYEKIGTLHCEIDAYGDFLQALGPGATVEYTKNTSNVTKEESELVDMRQRIFHLLKGTPLNVVVLNNSKFYHIGTTEEYLFHFTADSSLKSELGLQSIAFSLFPSIPECSTNKPCIIQSILDSTCSVTPGSVVEYSRLGPDVSVEENCIISGAYVKTTAVLPAYSFVCSLSLKMNGHLKYSTMACGVQDNLKKNVKTLSDVKLLQFFGVCFLSCLDIWNLKVTEELFSGNKTCLSLWNARIFPVCSSLSDSVTTSLKMLNAVQSKSAFSLNNYKLLSIEEMLFYKDIEDMITYREQIFLEITLNRKQSDLETSY", "length": 569, "header": "tr|A0AAA9T9K6-1|E1B9U5_BOVIN Computationally mapped isoform of Fucose-1-phosphate guanylyltransferase OS=Bos taurus OX=9913 GN=FPGT PE=4 SV=1 CANONICAL=E1B9U5-1" }, "locus": { "chromosome": "3", "start_pos": 70608293, "end_pos": 70601769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134586.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134586.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094680.1" } ] } }, { "isoform_ac": "A0AAA9TNR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR7/entry", "sequence": { "sequence": "MEAESAPAGESLREATQRRLLRFSELRGKSMAAGEFWDIVAITAADEKQELAYKQQLSEKLKKKELPLGVQYHVFVDPAGAKIGNGGSTLCALRCLEKLYGDKWNSFTILLIHSASFHRYQNALLTNPVLSKVYWIQHVLHLAQLWSIPDWGLMFQLRKIASLVVLMSK", "length": 169, "header": "tr|A0AAA9TNR7-1|E1B9U5_BOVIN Computationally mapped isoform of Fucose-1-phosphate guanylyltransferase OS=Bos taurus OX=9913 GN=FPGT PE=4 SV=1 CANONICAL=E1B9U5-1" }, "locus": { "chromosome": "3", "start_pos": 70608293, "end_pos": 70602242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125264.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125264.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100007.1" } ] } }, { "isoform_ac": "E1B9U5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U5/entry", "sequence": { "sequence": "MEAESAPAGESLREATQRRLLRFSELRGKSMAAGEFWDIVAITAADEKQELAYKQQLSEKLKKKELPLGVQYHVFVDPAGAKIGNGGSTLCALRCLEKLYGDKWNSFTILLIHSGGYSQRLPSASALGKIFTALPFGSPIYQMLELKLAMYIDFPSHMNPGILITCADDIELYSIGESEFIRFDKPGFTALAHPSSLTVGTTHGVFVLEPCNHLEYRDLEYRSCHRFLHKPSVEEMYEFDAVCRPRNFFQQEFAGSDIPSLKLEPEYVYTDSLFYMDHKTAKKLLAFYEKIGTLHCEIDAYGDFLQALGPGATVEYTKNTSNVTKEESELVDMRQRIFHLLKGTPLNVVVLNNSKFYHIGTTEEYLFHFTADSSLKSELGLQSIAFSLFPSIPECSTNKPCIIQSILDSTCSVTPGSVVEYSRLGPDVSVEENCIISGAYVKTTAVLPAYSFVCSLSLKMNGHLKYSTMACGVQDNLKKNVKTLSDVKLLQFFGVCFLSCLDIWNLKVTEELFSGNKTCLSLWNARIFPVCSSLSDSVTTSLKMLNAVQSKSAFSLNNYKLLSIEEMLFYKDIEDMITYREQIFLEITLNRKQSDLETSY", "length": 600, "header": "tr|E1B9U5-1|E1B9U5_BOVIN Isoform 1 of Fucose-1-phosphate guanylyltransferase OS=Bos taurus OX=9913 GN=FPGT PE=4 SV=2 CANONICAL=E1B9U5-1" }, "locus": { "chromosome": "3", "start_pos": 70608293, "end_pos": 70601769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055149.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055149.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049353.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049353.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 414, "start_aa": "Thr", "end_pos": 414, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr414", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100138313", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138313", "resource": "KEGG Pathway" }, { "id": "R-BTA-6787639", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6787639", "resource": "Reactome", "description": "GDP-fucose biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0C0-1", "protein_name": "Fucose-1-phosphate guanylyltransferase", "gene_name": "Fpgt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METLREATLRKLRRFSELRGKPVAAGEFWDVVAITAADEKQELAYKQQLSEKLRRKELPLGVQYHVFPDPAGTKIGNGGSTLCSLQCLESLYGDEWNSFKVLLIHSGGYSQRLPNASALGKIFTALPLGEPIYQMLELKLAMYVDFPSHMKPGVLVTCADDIELYSVGDCQYIAFDQPGFTALAHPSSLAVGTTHGVFVLHSASSLQHGDLEYRQCHRFLHKPTIENMHQFNAVQRQGSFAQQDFPGGDTACLPLHTEYVYTDSLFYMDHKSAKKLLDFYKSVDQLNCEIDAYGDFLQALGPGATAEYTRNTSHVTKEDSQLLDMRQKIFHLLKGTPLNVVVLNNSRFYHIGTTQEYLLHFTSDSTLRSELGLQSIAFSVSPSVPESSNETACIIHSILDSGCCVAPGSVVEYSRLGPEVSIGENCIVSSSVLANTAVPAYSFVCSLSVRTNGLLEYSTMVFSVQDNLKGSVKTLEDIKALQFFGVCFLSCLDIWNLKATEKLFSGSKRNLSLWTARIFPVCPSLSESVTASLGMLSAVRSHSPFSLSNFKLMSIQEMLVYKDVQDMLAYREQIFLEINSNKKQSDLEKS", "length": 590 }, "evidence": [ { "id": "E1B9U5", "url": "https://omabrowser.org/oma/group/E1B9U5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8D1BV64-1", "protein_name": "Fucose-1-phosphate guanylyltransferase", "gene_name": "FPGT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAASAPLGVSLQEATQRRLRRFSELRGKPVAAGEFWDIVAITAADEKQELAYKQQLSEKLKKKELPLGVQYLVFVDPAGAKIGNGGSTLCALRCLEKLYGDQWNSFTILLIHSGGYSQRLPNASALGKIFTALPFGSPIYQMLELKLAMYIDFPSHMNPGILVTCADDIELYSIGESEFIRFDKPGFTALAHPSSLTVGTTHGVFVLEPFNRLEYRDLEYRCCHRFLHKPSIEMMYKFDAVCRPGNFSQQDFGGGDTPSLKLDPEYVYTDSVFYMDHKTAKKLLAFYEKIDTLNCEIDAYGDFLQALGPGATVEYTRNTSNVTKEESELVDMRQRIFHLLKGTPLNVIVLNNSKFYHIGTTKEYLFHFTSDSSLKSELGLQSIAFSIFPAIPEYSGNKSCIIQSILDSRCSLAPGSVVEYSRLGPDVSVGENCIISGSHIITRAILPAYSFVCSLSLKINGHIKYSTMACGVQDNLKKNVKTLSDVKLLQFFGVSLLSCLDVWNLEVTEELFSGNKTCLSLWNARIFPVCSSLSDSVIASLKMLNAVQSKSVFSLNNYKLLSIEEMLVYKDVEDMITYREQIFLEIALNRKQSVLETS", "length": 599 }, "evidence": [ { "id": "E1B9U5", "url": "https://omabrowser.org/oma/group/E1B9U5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1QSV4-1", "protein_name": "2.7.7.30", "gene_name": "fpgt", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTERGNVYLQKSTKDKIEKFNKMRGKAVKSEEFWDLVVITAMDEDQRSAYEIQITDKLERKELPLGINYHVFADPPGCKIGNGGSTLHSLQCLHDKYGKSLSGFKVILIHAGGFSQRLPNASALGKIFTAFPLGNPLYQMLELKLAMYVDFPSHMKPGMLVTCSDDIELYSIPDQEFVVFDKPGFTALAHPSSLSIGTTHGVFVLEPAEVPTISDMQYRTCSQFLHKPTIERMRKSNAICKRKEEEFVYTDSTYYIDHSTAMTLLHIFSEISPLTCEVDAYGDFLQALGRRASVDYTENTANVTKKEKGLVEIRRKIFHRLKGTALNVILLNNSKFYHVGTTEEYLFHLTADPCLRAELGLMASAFSSFILEKTRVCVMHSILHPSVSVSEGSVVEYCRLDANVYVGSRSIISGSWIGTDLKVPSDTFMHSLSVNLDGSTGFVTVAFGVLDDLKKNVPRPADMKALSLFKRSLEDCVGLWGLCLEKVRFSGDASVCSLWNACIFPVCSDLKDSFQMSLKMVKALDGGNTFTLPKNTKLTSLQETLQSKNLEEMLKYRKGLYEDILRVNLSNSL", "length": 573 }, "evidence": [ { "id": "E1B9U5", "url": "https://omabrowser.org/oma/group/E1B9U5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G5E8F4-1", "protein_name": "Fucose-1-phosphate guanylyltransferase", "gene_name": "Fpgt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLREATLRKLRRFSELRGKPVAAGEFWDVVAITAADEKQELAYKQQLSEKLKKRELPLGVQYHVFPDPAGTKIGNGGSTLCSLECLESLCGDKWNSLKVLLIHSGGYSQRLPNASALGKIFTALPLGEPIYQMLELKLAMYVDFPSNMRPGVLVTCADDIELYSVGDSEYIAFDQPGFTALAHPSSLAVGTTHGVFVLHSDSSLQHGDLEYRQCYQFLHKPTIENMHRFNAVHRQRSFGQQNLSGGDTDCLPLHTEYVYTDSLFYMDHKSAKKLLDFYKSEGPLNCEIDAYGDFLQALGPGATAEYTRNTSHVTKEESQLLDMRQKIFHLLKGTPLNVVVLNNSRFYHIGTLQEYLLHFTSDSALKTELGLQSIAFSVSPSVPERSSGTACVIHSIVDSGCCVAPGSVVEYSRLGPEVSIGENCIISSSVIAKTVVPAYSFLCSLSVKINGHLKYSTMVFGMQDNLKNSVKTLEDIKALQFFGVCFLSCLDIWNLKATEKLFSGNKMNLSLWTACIFPVCSSLSESATASLGMLSAVRNHSPFNLSDFNLLSIQEMLVYKDVQDMLAYREHIFLEISSNKNQSDLEKS", "length": 590 }, "evidence": [ { "id": "E1B9U5", "url": "https://omabrowser.org/oma/group/E1B9U5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O14772-1", "protein_name": "Fucose-1-phosphate guanylyltransferase", "gene_name": "FPGT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRAVRRGLREGGAMAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAMYIDFPLNMNPGILVTCADDIELYSIGEFEFIRFDKPGFTALAHPSSLTIGTTHGVFVLDPFDDLKHRDLEYRSCHRFLHKPSIEKMYQFNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAFYEKIGTLSCEIDAYGDFLQALGPGATVEYTRNTSNVIKEESELVEMRQRIFHLLKGTSLNVVVLNNSKFYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDIPECSGKTSCIIQSILDSRCSVAPGSVVEYSRLGPDVSVGENCIISGSYILTKAALPAHSFVCSLSLKMNRCLKYATMAFGVQDNLKKSVKTLSDIKLLQFFGVCFLSCLDVWNLKVTEELFSGNKTCLSLWTARIFPVCSSLSDSVITSLKMLNAVKNKSAFSLNSYKLLSIEEMLIYKDVEDMITYREQIFLEISLKSSLM", "length": 607 }, "evidence": [ { "id": "E1B9U5", "url": "https://omabrowser.org/oma/group/E1B9U5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54NH4-1", "protein_name": "Fucose-1-phosphate guanylyltransferase", "gene_name": "fpgt", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMELGFENDIDLLNQYQTIQSRKTKDYKKFLEIKQENKNQHLDIISSFWDVIVITAIDSLQKEYYEQVLKEKMNQNQIPSFIPYVVISDPVGEKIGCGGSTLYVLKTLSTIFGDDKIKNMKILLLHAGGYSKRLPNHSTTGKIFASIPCTLGMGGNNNNNNDDEDESKLQACSMLEIKLIILIDIPKRMKPGVFLACSDDIELFESNEMSFNSSEDGTFIALSQPGTLDIGVGHGVFILDDVNQYKPNQLNSCRKFIHKPSKEKMKNENAILSNGLVLMDSCYYFDHKVFSILLNYYNQNNPINCEIDAYSDFLQPLGKSAEPNYFQVKSNVTKFLPHLPKEREKIYNFLNSNKCKLEMIPMSPSAFIHIGTCHEYIEHFTINFPKLGFKNLIFSEIGSGINNNNNNNSVILHSILLNNLNTIINDNSVIEYCNFKGINKLSIGNRCIVSDLEFENSNEQQQQQQQQQQQQQQQQQTLSSSNYSIEIPSNSFIQTLSISCNRYVTIFFGIDDDLKSTTNPKLFGIPLKDYNLNSINTSDDNNNNNSLWNAPLFPISNISPKDSLLKTLNSLQKTKQTNFFSNNEQQPQQQQQSYYSIEQCLNEKDLSKQFIRRSNLTNEILNLKNKK", "length": 627 }, "evidence": [ { "id": "E1B9U5", "url": "https://omabrowser.org/oma/group/E1B9U5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "pmid": "" }, { "name": "transferase activity, transferring phosphorus-containing groups", "id": "GO:0016772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016772", "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "pmid": "" }, { "name": "fucose-1-phosphate guanylyltransferase activity", "id": "GO:0047341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047341", "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "GDP-L-fucose biosynthetic process", "id": "GO:0042350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042350", "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "pmid": "" }, { "name": "GDP-L-fucose salvage", "id": "GO:0042352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042352", "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "pmid": "" }, { "name": "L-fucose metabolic process", "id": "GO:0042354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042354", "evidence": [ { "database": "UniProtKB", "id": "E1B9U5", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9U5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 600, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9U5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9U5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U5" }, { "id": "PF07959", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07959" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GDP-fucose pyrophosphorylase", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 532, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 414 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 319, "end_pos": 321 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 516, "end_pos": 518 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8Z7-1", "uniprot_ac": "E1B8Z7", "uniprot_id": "E1B8Z7_BOVIN", "mass": { "chemical_mass": 25375.0, "monoisotopic_mass": 25375.0 }, "refseq": { "ac": "NP_001179309", "name": "max dimerization protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179309" }, "gene_names": [ { "name": "MXD1", "type": "recommended", "evidence": [ { "id": "E1B8Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ] }, { "name": "MXD1", "type": "synonym", "evidence": [ { "id": "NP_001179309", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179309" } ] } ], "protein_names": [ { "name": "MAX dimerization protein 1", "type": "synonym", "evidence": [ { "id": "E1B8Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7/entry#names_and_taxonomy" } ] }, { "name": "max dimerization protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179309", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179309" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MXD1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7", "locus": { "chromosome": "11", "start_pos": 68282676, "end_pos": 68259733, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001042", "url": "https://www.ensembl.org/id/ENSBTAG00000001042" } ] } } ], "crossref": [ { "id": "E1B8Z7", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Z7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001042", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001042", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18931", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18931", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514626", "url": "https://www.ncbi.nlm.nih.gov/gene/514626", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514626", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514626", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SSTHNEM", "url": "https://omabrowser.org/oma/group/SSTHNEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUI0", "url": "https://www.orthodb.org/?gene=A0A3Q1LUI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8Z7", "url": "https://www.orthodb.org/?gene=E1B8Z7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179309", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUI0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Z7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRSKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESNRHTTLSLLTKAKLHIKKLEDCDRKAIHQIDQLQREQRHLKRQLEKLGIERIRMDSTGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSCSSVSDSDERGSMQSLGSDEGYSSSSVKRIKLQDSHKTTCLGL", "length": 222, "header": "tr|E1B8Z7-1|E1B8Z7_BOVIN Isoform 1 of MAX dimerization protein 1 OS=Bos taurus OX=9913 GN=MXD1 PE=4 SV=1 CANONICAL=E1B8Z7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUI0/entry", "sequence": { "sequence": "MGNSGSMRLAVFLNNEQLECSLHLLRTEEAEHGYASMLPYNNKDRDALKRRSKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESNRHTTLSLLTKAKLHIKKLEDCDRKAIHQIDQLQREQRHLKRQLEKLGIERIRMDSTGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSCSSVSDSDERGSMQSLGSDEGYSSSSVKRIKLQDSHKTTCLGL", "length": 226, "header": "tr|A0A3Q1LUI0-1|A0A3Q1LUI0_BOVIN Computationally mapped isoform of MAX dimerization protein 1 OS=Bos taurus OX=9913 GN=MXD1 PE=4 SV=1 CANONICAL=E1B8Z7-1" }, "locus": { "chromosome": "11", "start_pos": 68281132, "end_pos": 68260486, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071951.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071951.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060792.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060792.1" } ] } }, { "isoform_ac": "A0AAA9RZ81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ81/entry", "sequence": { "sequence": "MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRSKSKKNNSSSRRAHLRLCLEKLKGLVPLGPESNRHTTLSLLTKAKLHIKKLEDCDRKAIHQIDQLQREQRHLKRQLEKLGIERIRMDSTGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSCSSVSDSDERGSMQSLGSDEGYSSSSVKRIKLQDSHKTTCLGL", "length": 212, "header": "tr|A0AAA9RZ81-1|E1B8Z7_BOVIN Computationally mapped isoform of MAX dimerization protein 1 OS=Bos taurus OX=9913 GN=MXD1 PE=4 SV=1 CANONICAL=E1B8Z7-1" }, "locus": { "chromosome": "11", "start_pos": 68281132, "end_pos": 68259932, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135474.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135474.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077947.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077947.1" } ] } }, { "isoform_ac": "E1B8Z7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7/entry", "sequence": { "sequence": "MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRSKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESNRHTTLSLLTKAKLHIKKLEDCDRKAIHQIDQLQREQRHLKRQLEKLGIERIRMDSTGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSCSSVSDSDERGSMQSLGSDEGYSSSSVKRIKLQDSHKTTCLGL", "length": 222, "header": "tr|E1B8Z7-1|E1B8Z7_BOVIN Isoform 1 of MAX dimerization protein 1 OS=Bos taurus OX=9913 GN=MXD1 PE=4 SV=1 CANONICAL=E1B8Z7-1" }, "locus": { "chromosome": "11", "start_pos": 68281132, "end_pos": 68259932, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001384.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001384.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001384.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001384.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514626", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514626", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2BFZ1-1", "protein_name": "Max dimerization protein 1", "gene_name": "mxd1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTAIEKLQMLIEAAEYLDRREREAEHGYASMLPFTSNKERDGLKRKIKSKKNCSSRSTHNEMEKNRRAHLRLCLERLKSLVPLGPESNRHTTLSLLMRAKEHIKRLEDSERKAQHTIDQLQREQRHLRRRLEQLGVERTRMDSMGSTISSDKSDSDQEEVDVDVEGTDYLLGDLEWSTSSVSDSDERGSLRSSCSDEGYSSASLRRLANSQENSLVLACSL", "length": 221 }, "evidence": [ { "id": "E1B8Z7", "url": "https://omabrowser.org/oma/group/E1B8Z7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1LRY0-1", "protein_name": "Max dimerization protein 1", "gene_name": "Mxd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATAVGMNIQLLLEAADYLERREREAEHGYASMLPYSSKDRDAFKRRNKPKKNSTSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRRLEKLGAERTRMDSVGSVVSSERSDSDREELDVDVDVDVDVDVDVDVESTDYLNGDLGWSSSVSDSDERGSMQSLGSDEGYSSASVKRAKLQDGHKAGPGL", "length": 232 }, "evidence": [ { "id": "E1B8Z7", "url": "https://omabrowser.org/oma/group/E1B8Z7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SLC7-1", "protein_name": "MAX dimerization protein 1", "gene_name": "MXD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRSKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESNRHTTLSLLTKAKLHIKKLEDCDRRAIHQIDQLQREQRHLKRQLEKLGIERIRMDSTGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSSSIQRIKLQDNHQTCLGL", "length": 221 }, "evidence": [ { "id": "E1B8Z7", "url": "https://omabrowser.org/oma/group/E1B8Z7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q05195-1", "protein_name": "Max dimerization protein 1", "gene_name": "MXD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL", "length": 221 }, "evidence": [ { "id": "E1B8Z7", "url": "https://omabrowser.org/oma/group/E1B8Z7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z7", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Z7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 222, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Z7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Z7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z7" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 108, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 53, "end_pos": 55 }, { "start_pos": 54, "end_pos": 56 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBI5-1", "uniprot_ac": "E1BBI5", "uniprot_id": "E1BBI5_BOVIN", "mass": { "chemical_mass": 119144.0, "monoisotopic_mass": 119144.0 }, "refseq": { "ac": "NP_001192485", "name": "zinc finger and BTB domain-containing protein 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192485" }, "gene_names": [ { "name": "ZBTB11", "type": "recommended", "evidence": [ { "id": "E1BBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ] }, { "name": "ZBTB11", "type": "synonym", "evidence": [ { "id": "NP_001192485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192485" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 11", "type": "recommended", "evidence": [ { "id": "E1BBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBI5/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 11", "type": "synonym", "evidence": [ { "id": "NP_001192485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192485" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9S0W7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0W7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB11", "url": "https://www.uniprot.org/uniprotkb/E1BBI5", "locus": { "chromosome": "1", "start_pos": 46028911, "end_pos": 46058876, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013460", "url": "https://www.ensembl.org/id/ENSBTAG00000013460" } ] } } ], "crossref": [ { "id": "E1BBI5", "url": "https://alphafold.ebi.ac.uk/entry/E1BBI5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013460", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013460", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18202", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18202", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538545", "url": "https://www.ncbi.nlm.nih.gov/gene/538545", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538545", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538545", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYAFIMH", "url": "https://omabrowser.org/oma/group/RYAFIMH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBI5", "url": "https://www.orthodb.org/?gene=E1BBI5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S0W7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0W7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSEESYQAILRYLTNECEPYAPGTEGNVKRKIRKAAACYVVRDGTLYYQRRQRHRKTFAELEVVLQPERRRGLIEAAHLGPGGTHHTQHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDASEMLEELGLDLESGEESNESEDDLSNFTSPPTTASKPVKKKPVSKHELVFVDTRGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLQEQSGGTAPPVANNTGTTTTLSTELGDCEIVLLMNGELPEQNGELGQQPEPQVSSQAEATASPVGCVTDSHPEMESVDLVTKNNQTELETLNSREDSTVSSTHPKPSQENVISSSPGNTDTGNDTAAEDICAEDISEHRQDLDPSSKDEENLAEPTALMDQSPDDDTYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAIPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEEASHKCGECGMFFQRRYALIKHILKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPTSSSSSSASNEASGSSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEQCGRKFTQLREYRRHMNNHGGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQEQENNGPQELETVVVTGETMEALEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHISETE", "length": 1052, "header": "tr|E1BBI5-1|E1BBI5_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 11 OS=Bos taurus OX=9913 GN=ZBTB11 PE=4 SV=2 CANONICAL=E1BBI5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0W7/entry", "sequence": { "sequence": "MSSEESYQAILRYLTNECEPYAPGTEGNVKRKIRKAAACYVVRDGTLYYQRRQRHRKTFAELEVVLQPERRRGLIEAAHLGPGGTHHTQHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDASEMLEELGLDLESGEESNESEDDLSNFTSPPTTASKPVKKKPVSKHELVFVDTRGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLQEQSGGTAPPVANNTGTTTTLSTELGDCEIVLLMNGELPEQNGELGQQPEPQVSSQAEATASPVGCVTDSHPEMESVDLVTKNNQTELETLNSREDSTVSSTHPKPSQENVISSSPGNTDTGNDTAAEDICAEDISEHRQDLDPSSKDEENLAEPTALMDQSPDDDTYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAIPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEEASHKCGECGMFFQRRYALIKHILKHERARDYKCPVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEQCGRKFTQLREYRRHMNNHGGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQEQENNGPQELETVVVTGETMEALEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHISETE", "length": 970, "header": "tr|A0AAA9S0W7-1|E1BBI5_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 11 OS=Bos taurus OX=9913 GN=ZBTB11 PE=4 SV=1 CANONICAL=E1BBI5-1" }, "locus": { "chromosome": "1", "start_pos": 46058280, "end_pos": 46028952, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112275.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112275.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079511.1" } ] } }, { "isoform_ac": "E1BBI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI5/entry", "sequence": { "sequence": "MSSEESYQAILRYLTNECEPYAPGTEGNVKRKIRKAAACYVVRDGTLYYQRRQRHRKTFAELEVVLQPERRRGLIEAAHLGPGGTHHTQHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDASEMLEELGLDLESGEESNESEDDLSNFTSPPTTASKPVKKKPVSKHELVFVDTRGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLQEQSGGTAPPVANNTGTTTTLSTELGDCEIVLLMNGELPEQNGELGQQPEPQVSSQAEATASPVGCVTDSHPEMESVDLVTKNNQTELETLNSREDSTVSSTHPKPSQENVISSSPGNTDTGNDTAAEDICAEDISEHRQDLDPSSKDEENLAEPTALMDQSPDDDTYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAIPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEEASHKCGECGMFFQRRYALIKHILKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPTSSSSSSASNEASGSSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEQCGRKFTQLREYRRHMNNHGGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQEQENNGPQELETVVVTGETMEALEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHISETE", "length": 1052, "header": "tr|E1BBI5-1|E1BBI5_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 11 OS=Bos taurus OX=9913 GN=ZBTB11 PE=4 SV=2 CANONICAL=E1BBI5-1" }, "locus": { "chromosome": "1", "start_pos": 46058280, "end_pos": 46028952, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017903.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017903.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017903.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017903.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538545", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538545", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XRC7-1", "protein_name": "Zinc finger and BTB domain-containing protein 11", "gene_name": "ZBTB11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSEESYLAILRYLTNEREPYAPGTEGNAKRKIRKAAACYVVRGGTLYYQRRQRDQQRFAELEVVLQAERRARLIRAAHLAPDGAHRTRLQTWQGLSQKYWWRGILKQVKDYIKECSKCQEKLDRSRSLSDPSEMLEELGLDVKSHEDSNETDDEVSNAASIPAASPKPVKKKPIAKHELVFVDSKGLVKQSSSKHCLSVLNQLNQQRLSNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVTSHEAVVDLSGFCKSSFLPLLEFAYTSELTFDFCSMAELAMLARHLLMSEVLEICENVHKQMEEKQITVYQKGDIQTVESTRNLAEQTAVQMPPVDGAEQPLPVELTASEVTATVNGAPSSLEPEEKGEPQPGILPPGPVEASADDLPKPVEQSEAIENGVKTVESISNSPTSARQPEPSVVEAMNTESPLEKETDENENCKVSAETISEDSSEMLKEKHGRQSREQSLSASPPESLASSQDDTYKSKLRQRSVSEGGYIRLHKGIEKKLQNRKTNPKSAIQQVAMKLVQRGKKMKQPKRETTENNEVEAQHKCTECGMVFQRRYALIMHTLKHERSKDYKCPLCKKEFQYGASLRAHLVRHTRKTEVNAAADGVEETGVSSVKGRTKREFICDICGRTLPKLYSLRIHMLKHTGVKPHACKVCGKTFTYKHGLKMHLALHEVQKQFKCDLCEKSFVTKRSLQEHMSIHTGESKYLCTICGKSFHRASGLSKHIKKHQPKPEVRGYQCTQCEKSFYEARDLRQHMNKHLDVKPFQCQFCGKCYSWKKDWYSHVKSHSVTDPYRCNVCGKEFYEKALYRRHVKKATHGKKGRAKQNLERVCEHCGRKFTQLREYRRHMNNHQGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCNEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAISILAADMQEQETEISVGGEEIETVVVTGDTLEAIEAVATTEQCTSVSTLSDQSIMQVVNYVLAQQQGQKMAEVTQAMETVEVEVAHVTETE", "length": 1045 }, "evidence": [ { "id": "E1BBI5", "url": "https://omabrowser.org/oma/group/E1BBI5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZDP9-1", "protein_name": "Zinc finger and BTB domain-containing protein 11", "gene_name": "Zbtb11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRQGLIEAAHLGPGGTHHTRHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDASEMLEELGLDLESGEESNESEDDLSNFTSPPTTASKTSKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAVLARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLAAHNGAATPPGPRNEATTTLSSDLGHCEIVLLVNGEVPETEQNGEPGQQPAPQVSAEAEASVSPAGCIPNPPTEMGAASLATESNQPELESAVVREDGGVASVPPKISEENVINTSQEDSDIGNDTSPEDTCTKDFSDHSQSSGQPLKDEETLIEATEKTDSGQDDDTYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAISKSAVQQVAQKLVQRGKKMKQPKRDAKESAEETPHKCGECGMVFPRRYAFIMHTLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPTSSSSNSTSNEASGASSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYFCSVCGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQEQESSGPQELETVVVTGETMEVLEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHMPEAE", "length": 1052 }, "evidence": [ { "id": "E1BBI5", "url": "https://omabrowser.org/oma/group/E1BBI5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RAC1-1", "protein_name": "Zinc finger and BTB domain-containing protein 11", "gene_name": "zbtb11", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSEESYLAIQRYLTDEREPYAPGTHGNTKRKIRKAAACYIVRNGILYYQRRQKGLDEFTELEVVLTADRRKELITEAHITSGGEHLNQQQTWEIISQKYWWRGVLKQVKDCIKECIHCQTKQEKGRNNTEDAPKQTARQVRQKISSACASEEEDDEIHEDLEEEQSTTVDKHELVFVDSKGIVKQFLQKHGQTMLDKLNLQRMNNEFCDITLIIEGEEYRAHKAVLASCSDYFYELFVEKGAVSSHEAVVDLSGFSKASFLPLLDFAYTSNLTFNFCVMAEVATLARHLLMAEVLQICESVHKKVEEQKLMVYQRGDIHTVLPNQPASTQPITPTAAETYVVTMQSDGTAEAGQSLAVITSEIGTAESLALLAGATVDGETMTVVTHSGQAGSAESLAMVAHSGQAEEGETMTLVTHSGQAGSGESLAVVQACWSVEEPQVGDTPVVQSMQTGAFLISVDPGKTGASEIVHLAAAAPPAVQDEPQASKPIHQTEPPAAAPQPSPAPLKRRPGRPPKVKQQEPPPPLPSEDEPMEMEGVEDDEKQEDECIDPNKRYLRKRSVREGGYVRLHMGLETEEEEKITSPPAKIPQKGLAKRGRPVQSAKKNPETEFSETNLEAAPNAIVTSAKEPEPVIVEQPETVEEGALPGDPEGAVEGEHACNECGMVFQRRYTLIMHALKHEKARIFKCSICNKEFQYAASLRAHLARHKHQKSQRASLTRAMATEDSQGSDDQARFRTRREFVCDICGKTMPKLYSLRIHMLNHTGVRPHSCKVCGKSFATKHSLKMHRALHDSLKRFHCTVCEKSFVTKRSLEEHTSIHTGESKYLCTTCGASFHRASGLSKHLKKHQPKPEVRSFHCSHCDKSFFEAKDLQQHMNKHLGLKPFQCQVCGKCYSWKKDWYSHVKSHSVAEPFRCNVCGKEFFEKALFRRHVKKATHGKKGRVKQNLERECEHCGRKFTQLREYRRHMNNHQGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPLCQEAHIDARTLRKHITKFHGDQLPGKIMLEKDTLQFHNQGTQVEHAVSILSSELPPELQPPQPPATEEIETVLITEETVEAVQAMNDGAAVTTLSDQSIMQVVNYVLAQQAAVKVEEAPEIIQTMEVEVAHVAEVE", "length": 1146 }, "evidence": [ { "id": "E1BBI5", "url": "https://omabrowser.org/oma/group/E1BBI5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G5E8B9-1", "protein_name": "Zinc finger and BTB domain-containing protein 11", "gene_name": "Zbtb11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRQGLIEAAHLGPGGTHHTRHQTWHDLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDASEMLEELGLDLDSGEESNESEDDLSNFTSPPSTASKSSKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAVLARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLAAHNGTTTPPGTRNEATTTLSGELGHCEIVLLVNGELPEAEQNGEPEQQPAPQASPEAEASVSPVEGIPEPHPEMGTASLAKESNQPESAVTREDGIVASVHPKISKENVTNASQEDSDTGNDTSPEDIGAKDCPDHSQSPGQPSKDEDTLTEATEKTDSGPDDDTYRSRLRQRSVNEGGYIRLHKGMEKKLQKRKAISKSAVQQVAQKLVQRGKKMKQPKRDAKESTEETAHKCGECGMVFPRRYAFIMHTLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKEAPTSSSSNSTSTEASGGSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYFCSICGKSFHRGSGLSKHLKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVEHAVSILTADMQEQESSGPQELETVVVTGETMEVLEAVAATEECPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVEVEVAHMPEAE", "length": 1050 }, "evidence": [ { "id": "E1BBI5", "url": "https://omabrowser.org/oma/group/E1BBI5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O95625-1", "protein_name": "Zinc finger and BTB domain-containing protein 11", "gene_name": "ZBTB11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRRDLIEAAHLGPGGTHHTRHQTWHYLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDVSEMLEELGLDLESGEESNESEDDLSNFTSSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQNGEVGRQPEPQVSSEAESALSSVGCIADSHPEMESVDLITKNNQTELETSNNRENNTVSNIHPKLSKENVISSSPEDSGMGNDISAEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTYRSRLRQRSVNEGAYIRLHKGMEKKLQKRKAVPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEASHKCGECGMVFQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHFKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEKCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHAVSILTAGMQEQESSGPQELETVVVTGETMEALEAVAATEEYPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVKVEVAHISGGE", "length": 1053 }, "evidence": [ { "id": "E1BBI5", "url": "https://omabrowser.org/oma/group/E1BBI5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BBI5", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBI5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1052, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBI5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBI5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 282, "start_aa": "Cys", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBI5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 568, "end_pos": 595, "start_aa": "His", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 158, "end_pos": 160 }, { "start_pos": 346, "end_pos": 348 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 456, "end_pos": 458 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B783-1", "uniprot_ac": "E1B783", "uniprot_id": "E1B783_BOVIN", "mass": { "chemical_mass": 96381.0, "monoisotopic_mass": 96381.0 }, "refseq": { "ac": "NP_001192789", "name": "tetratricopeptide repeat protein 13 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192789" }, "gene_names": [ { "name": "TTC13", "type": "recommended", "evidence": [ { "id": "E1B783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B783" } ] }, { "name": "TTC13", "type": "synonym", "evidence": [ { "id": "NP_001192789", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192789" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 13", "type": "synonym", "evidence": [ { "id": "E1B783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B783/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 13 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192789", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192789" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B783", "url": "https://www.uniprot.org/uniprotkb/E1B783" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC13", "url": "https://www.uniprot.org/uniprotkb/E1B783", "locus": { "chromosome": "28", "start_pos": 3633670, "end_pos": 3714489, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010367", "url": "https://www.ensembl.org/id/ENSBTAG00000010367" } ] } } ], "crossref": [ { "id": "E1B783", "url": "https://alphafold.ebi.ac.uk/entry/E1B783", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010367", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010367", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519575", "url": "https://www.ncbi.nlm.nih.gov/gene/519575", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519575", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519575", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEMALYT", "url": "https://omabrowser.org/oma/group/KEMALYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B783", "url": "https://www.orthodb.org/?gene=E1B783", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44523:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44523:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192789", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B783", "url": "https://www.uniprot.org/uniprotkb/E1B783", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B783-1", "url": "https://www.uniprot.org/uniprotkb/E1B783-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAGCCCGGCWGGAVAAADAARSVLVLLLLGVLSAGPGPGALATEHYSPLSLLKQELQHRQQQEAPAGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSPPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLHEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPAQSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKIAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSSPRCLKKL", "length": 858, "header": "tr|E1B783-1|E1B783_BOVIN Isoform 1 of Tetratricopeptide repeat domain 13 OS=Bos taurus OX=9913 GN=TTC13 PE=4 SV=1 CANONICAL=E1B783-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K3/entry", "sequence": { "sequence": "MAPAGCCCGGCWGGAVAAADAARSVLVLLLLGVLSAGPGPGALATEHYSPLSLLKQELQHRQQQEAPAGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSPPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLHEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPAQSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKIAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSSPRCLKKL", "length": 805, "header": "tr|A0AAA9S4K3-1|E1B783_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 13 OS=Bos taurus OX=9913 GN=TTC13 PE=4 SV=1 CANONICAL=E1B783-1" }, "locus": { "chromosome": "28", "start_pos": 3714384, "end_pos": 3634347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125729.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125729.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077064.1" } ] } }, { "isoform_ac": "A0AAA9SQB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB1/entry", "sequence": { "sequence": "MAPAGCCCGGCWGGAVAAADAARSVLVLLLLGVLSAGPGPGALATEHYSPLSLLKQELQHRQQQEAPAGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSPPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLHEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPAQSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKIAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSSPRCLKKL", "length": 827, "header": "tr|A0AAA9SQB1-1|E1B783_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 13 OS=Bos taurus OX=9913 GN=TTC13 PE=4 SV=1 CANONICAL=E1B783-1" }, "locus": { "chromosome": "28", "start_pos": 3714384, "end_pos": 3634347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120555.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120555.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087556.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087556.1" } ] } }, { "isoform_ac": "E1B783-1", "url": "https://www.uniprot.org/uniprotkb/E1B783/entry", "sequence": { "sequence": "MAPAGCCCGGCWGGAVAAADAARSVLVLLLLGVLSAGPGPGALATEHYSPLSLLKQELQHRQQQEAPAGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSPPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLHEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPAQSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKIAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSSPRCLKKL", "length": 858, "header": "tr|E1B783-1|E1B783_BOVIN Isoform 1 of Tetratricopeptide repeat domain 13 OS=Bos taurus OX=9913 GN=TTC13 PE=4 SV=1 CANONICAL=E1B783-1" }, "locus": { "chromosome": "28", "start_pos": 3714384, "end_pos": 3634347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013692.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013692.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013692.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013692.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519575", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519575", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1SSC7-1", "protein_name": "Tetratricopeptide repeat domain 13", "gene_name": "Ttc13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPAGCGCGCSGSLGAAVVRPLLLLLGALACARATEHYSPLSLLKQELQHRQQQEAPAGGGCPQSGDWADQYPECESSFLNFHESDCELRGSAPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLVGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVIALEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNRNQPTAMLYKGLTFFHRGLLKEAIEAFKEALKQKVDFIDAYKSLGQAYRELGNFDAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLRVKYLREYSRYLHAHLDTPLTEYNIDSDLPGSFKDHWAKNLPFLIDGYEEQPGLQPHIRDVLHQNFEGYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVHRTWTNSKVRMNGKTRLLQWRDMFDIAVKWRRIADPDQPVLWLDQMPAPSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLTLSAEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKIAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSTPRCLKKL", "length": 844 }, "evidence": [ { "id": "E1B783", "url": "https://omabrowser.org/oma/group/E1B783/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F4JS25-1", "protein_name": "Suppressor of RPS4-RLD 1", "gene_name": "SRFR1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATATATSERFELAKHCSSRNWSKAIRVLDSLLAKESSILDICNRAFCYNQLELHKHVIKDCDKALLLEPFAIQAFILKGRALLALGRKQEAVLVLEQGYKSALQQTADVKQLLELEELLKDARREIDGILKSHATESPQETPAYHSEKSDEKSDKLDNHESGASSNGNSHESSSELGEQSKIVSFSKVASKASKQSDGNSDLCNGSVYKEKENGKCGSQINGYYESCKPCNGSDLHDNLAESSDRFGELSINGNKISIKSSKMSHKAEARCGISDESRKNKKYTIARISGTHSISVDFRLSRGIAQVNEGNYTKAISIFDKVLKEEPTYPEALIGRGTAYAFQRELESAIADFTKAIQSNPAASEAWKRRGQARAALGEYVEAVEDLTKALVFEPNSPDVLHERGIVNFKSKDFTAAVKDLSICLKQEKDNKSAYTYLGLAFASLGEYKKAEEAHLKSIQLDSNYLEAWLHLAQFYQELADHCKALECIEQVLQVDNRVWKAYHLRGLVFHGLGEHRKAIQELSIGLSIENTIECLYLRGSCYHAVGEYRDAVKDYDATVDVELDAVEKFVLQCLAFYQKELALYTASKVSSEFLCFDIDGDIDPMFKEYWCKRLHPKNVCEKVYRQPPLRESLKKGKLKKQDLAITKQKANILRFADLIGKRIQYDCPGFLPNKRQHRMAGLAVIEIAQKVSKAWRIEWRNSTKGTTKNGKKNRRRERTNILSQNRGGAGCSSSSFSETSTGYASLEDRSSGRSILSWQDVYSPAVRWRQISEPCDPVVWVNKLSEEFNSGFGSHTPMVLGQAKVVRYFPNYERTLTLAKSIIKDKLSVRSKKDKVIDLSKDEKIEKIMRAETCDELHNIVGEDFWVATWCDSTGSEGKRLEGTRITCIQKPGRLGYDFSIRTPCTPARWSDFDEEMTSAWEALCTAYCGENYGSTELDALETVRDAILRMTYYWYNFMPLARGTAVTGFVVLLGLLLAANMEFTETIPKGLQIDWEAILNVEPGSFVDSVKSWLYPSLKINTSWRDHTEISSAFSTTGAVVAALSTYND", "length": 1052 }, "evidence": [ { "id": "E1B783", "url": "https://omabrowser.org/oma/group/E1B783/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q75JW7-1", "protein_name": "Tetratricopeptide-like helical domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MINNSPPINIKSENIYQYQIQSIEYYNNEKYVECMNILNKLIELNTNDIIALCNRATCNYKLELYKHCIKDCEVILCKEPNNKIALLRKAKALKQLSNYDIELVNSLRKKANNSWGYLSVTIDDNDDGDDNNINSNINNINNNNNNNNNKNISISSPKTTTTSSIFISTSPPPYLSQQSQQQFHTMTIREQQQQQQQFLQEQQMLIYQEQQQQFLQEQQEMIDDLLSSPPLSLSEIHQKQHIQGDGNNIGEEEEDEEEEGEEGGIIVKSDSMEELNKLLEQLSTENIATLISQGNTFVNAGQYEEAIELFTMIIDNNPLVPSLYLGRGTSNAFLGQLNEAINDFSRAIELDNTSSDAYKRRGQSKVAKSMEQEALEDFNQAVAFDKEDDYDIYYNRGLLHYQMRNYERALKDFKKVTSIEPSHKLAWNRIGLCLNVNGYPMEAYQAFTEALRIDPYFEASHTNIGQCWKDLGKFDPSYQSFTKALEICPNYSNALHLRGLLFFNSGRHLDAIKDWNLFLKLYGSGGANSSGSNIKTGNHYSGGGGGGGGGEELSSIIDVRQFRGIVNQSIGAFRKAVADYDQILQTNPLHNCFYQREIALWTHHHLNTPLSTFNIDRFINCYLKTFQCQRIPNTSLTCNSISLGFQLQSSFNQSVADVEICHQLNNEQLSLFKEAKRIGEMLQYNCDGFLTNSRQKLQCGLSVIEMAQTLKKLWLSGNKKSSVFQLDGKSSSVSTKKHTFSWRDLYDIGVKWRQISEPNDPVWWGDLLSPEQFKEGFGSHTPIITGQCKVVRYYPMFEKSFEIMKLLLPIQHPSLISNQTILDQLESATTCKDLYKLIKKDFFVVTPCYSRSNENKVMEGTRLTLQYIHPEGYEFAIRTPSTPYRWEQYSQELDIIWDQLIDKVFIYQNIINSKEDLIDNSSSSSSSSPSPSPSNQESILLDEISDLILCLSFYWYNFMPLSRGSAALGFTTLLGLFLSLDIAITSSIPKNQQPDWEAILRPTTTSFISVIKPWLYPARSKFNLQTTSLVSSQFNTIKKMIQVLNNSNQY", "length": 1050 }, "evidence": [ { "id": "E1B783", "url": "https://omabrowser.org/oma/group/E1B783/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8NBP0-1", "protein_name": "Tetratricopeptide repeat protein 13", "gene_name": "TTC13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQHRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPSVSETFPTLRSMIEVLNTDSSPRCLKKL", "length": 860 }, "evidence": [ { "id": "E1B783", "url": "https://omabrowser.org/oma/group/E1B783/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B783-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 858, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B783-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B783" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC63-1", "uniprot_ac": "E1BC63", "uniprot_id": "E1BC63_BOVIN", "mass": { "chemical_mass": 123769.0, "monoisotopic_mass": 123769.0 }, "refseq": {}, "gene_names": [ { "name": "WDR72", "type": "recommended", "evidence": [ { "id": "E1BC63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC63" } ] } ], "protein_names": [ { "name": "WD repeat domain 72", "type": "synonym", "evidence": [ { "id": "E1BC63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC63/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC63", "url": "https://www.uniprot.org/uniprotkb/E1BC63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR72", "url": "https://www.uniprot.org/uniprotkb/E1BC63", "locus": { "chromosome": "10", "start_pos": 56779264, "end_pos": 56554695, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021876", "url": "https://www.ensembl.org/id/ENSBTAG00000021876" } ] } } ], "crossref": [ { "id": "E1BC63", "url": "https://alphafold.ebi.ac.uk/entry/E1BC63", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021876", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021876", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BC63", "url": "https://www.orthodb.org/?gene=E1BC63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44099:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44099:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23123", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23123", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC63", "url": "https://www.uniprot.org/uniprotkb/E1BC63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC63-1", "url": "https://www.uniprot.org/uniprotkb/E1BC63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSSLQAVALWGKKAPPHSITAIMITDDQQMIVTGSQEGQLCLWNLSSELKISAKELLFGHSASVMCLARARDFSKQPFVVSAAENGEMCVWNVTNGQCVEKAILPYRHTAICYYHCSARMTEGWLLCCGEYQDVLIIDAKSLVIIHTFVSSQSPDWINCICIVHSMTIQDSLLAVSVAGELKVWDLSSSINSIQEKQDVYEKESKFLDSLNCRAIRFCTYTERLLLVVFSKCWKVYDYCDFSLLWTEVSGSGQFFAGGEVLAAHRIIIWTEDGHSYIYQLLNSGLSKSIYPADGTLLKETIYPHLLCSTSVQENKLDQSLPFVMGYINERKEPFYKILFSGEVSGRITLWHIPDVPVSKFDGSPREIPITTTWTLQDNFDKHSTTSQTISDYFSGFKDENETVVVTSSEYVPSLDKLICGCEDGTIFITQALNAAKAGLLEGGSLLKGSLPQKVLKGHHHSVTSLLYPHGLSSKLDQSWLVSGDQDSWVILWNIFTEEILHKFFLQAGLVTSLLMSPENFKLRSYQVICCVCSDHSVALLHLEGRRCLLSARKHLFPVRMIKWHPVENFLVVGCADDSVYIWEIETGTLERHETGERAKIILNCCDDSQLPKPESILPVASETHKHKSVEQRSSSLSQFGPIPCPGLQVESSCKVADAKSFSGPFNVLLVKTKWSNIGFHILLFDLESLLELLLPTPIRDVDPSNSFYCSEILRRAKSTVEKTTLTLKRNKTVCGPLSTEVHAKPVGESPAQGDNTIKLSEENDGVKKQKKIKSFKKMHPKQSRKVDANLTIDTAKLLLSCLLPWGVDKELDNLCIKHLNILKLQGPVSLGLAANEDHFSLMLPGWDLYNTEMKKDYSKVNLFSRKVLDLSDKYTSTFPNHSGMPKGLENNSDSLQESNTIVYLLSKLFLVNKLVNMPLELAYGMDSAFKIESVHNKMKSPGNDILNISSFYSYLRNGKSESHLPEADVSLLKLISCWRDQSVQVTEAIQAVLLAEVQKHMKTLRKTPVNSEPESVAKNGDYEMMQMLPKIEWAKEPELQCTTDTFPPQTPVSSVKHDSNSNSANFQDTEDMPDRCVLEESESPGKRKHHLWIEKVCSCKLC", "length": 1103, "header": "tr|E1BC63-1|E1BC63_BOVIN Isoform 1 of WD repeat domain 72 OS=Bos taurus OX=9913 GN=WDR72 PE=4 SV=4 CANONICAL=E1BC63-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y9/entry", "sequence": { "sequence": "MLTHSSILATEIPWIKELHGLQPMGLQDSFTMRSSLQAVALWGKKAPPHSITAIMITDDQQMIVTGSQEGQLCLWNLSSELKISAKELLFGHSASVMCLARARDFSKQPFVVSAAENGEMCVWNVTNGQCVEKAILPYRHTAICYYHCSARMTEGWLLCCGEYQDVLIIDAKSLVIIHTFVSSQSPDWINCICIVHSMTIQEDSLLAVSVAGELKVWDLSSSINSIQEKQDVYEKESKFLDSLNCRAIRFCTYTERLLLVVFSKCWKVYDYCDFSLLWTEVSGSGQFFAGGEVLAAHRIIIWTEDGHSYIYQLLNRWAQMETAYKTFSGLSKSIYPADGTLLKETIYPHLLCSTSVQENKSLPFVMGYINERKEPFYKILFSGEVSGRITLWHIPDVPVSKFDGSPREIPITTTWTLQDNFDKHSTTSQTISDYFSGFKDENETVVVTSSEYVPSLDKLICGCEDGTIFITQALNAAKAGLLEGGSLLKGSLPQKVLKGHHHSVTSLLYPHGLSSKLDQSWLVSGDQDSWVILWNIFTEEILHKFFLQAGLVTSLLMSPENFKLRSYQVICCVCSDHSVALLHLEGRRCLLSARKHLFPVRMIKWHPVENFLVVGCADDSVYIWEIETGTLERHETGERAKIILNCCDDSQLPKPESILPVASETHKHKSVEQRSSSLSQFGPIPCPGLQVESSCKVADAKSFSGPFNVLLVKTKWSNIGFHILLFDLESLLELLLPTPIRDVDPSNSFYCSEILRRAKSTVEKTTLTLKRNKTVCGPLSTEVHAKPVGESPAQGDNTIKLSEENDGVKKQKKIKSFKKMHPKQSRKVDANLTIDTAKLLLSCLLPWGVDKELDNLCIKHLNILKLQGPVSLGLAANEDHFSLMLPGWDLYNTEMKKDYSKVNLFSRKVLDLSDKYTSTFPNHSGMPKGLENNSDSLQESNTIVYLLSKLFLVNKLVNMPLELAYGMDSAFKIESVHNKMKSPGNDILNISSFYSYLRNGKSESHLPEADVSLLKLISCWRDQSVQVTEAIQAVLLAEVQKHMKTLRKTPVNSEPESVAKNGDYEMMQMLPKIEWAKEPELQCTTDTFPPQTPVSSVKHDSNSNSANFQDTEDMPDRCVLEESESPGKRKHHLWIEKVCSCKLC", "length": 1144, "header": "tr|A0AAA9S4Y9-1|E1BC63_BOVIN Computationally mapped isoform of WD repeat domain 72 OS=Bos taurus OX=9913 GN=WDR72 PE=4 SV=1 CANONICAL=E1BC63-1" }, "locus": { "chromosome": "10", "start_pos": 56778260, "end_pos": 56582061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101294.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101294.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078912.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078912.1" } ] } }, { "isoform_ac": "E1BC63-1", "url": "https://www.uniprot.org/uniprotkb/E1BC63/entry", "sequence": { "sequence": "MRSSLQAVALWGKKAPPHSITAIMITDDQQMIVTGSQEGQLCLWNLSSELKISAKELLFGHSASVMCLARARDFSKQPFVVSAAENGEMCVWNVTNGQCVEKAILPYRHTAICYYHCSARMTEGWLLCCGEYQDVLIIDAKSLVIIHTFVSSQSPDWINCICIVHSMTIQDSLLAVSVAGELKVWDLSSSINSIQEKQDVYEKESKFLDSLNCRAIRFCTYTERLLLVVFSKCWKVYDYCDFSLLWTEVSGSGQFFAGGEVLAAHRIIIWTEDGHSYIYQLLNSGLSKSIYPADGTLLKETIYPHLLCSTSVQENKLDQSLPFVMGYINERKEPFYKILFSGEVSGRITLWHIPDVPVSKFDGSPREIPITTTWTLQDNFDKHSTTSQTISDYFSGFKDENETVVVTSSEYVPSLDKLICGCEDGTIFITQALNAAKAGLLEGGSLLKGSLPQKVLKGHHHSVTSLLYPHGLSSKLDQSWLVSGDQDSWVILWNIFTEEILHKFFLQAGLVTSLLMSPENFKLRSYQVICCVCSDHSVALLHLEGRRCLLSARKHLFPVRMIKWHPVENFLVVGCADDSVYIWEIETGTLERHETGERAKIILNCCDDSQLPKPESILPVASETHKHKSVEQRSSSLSQFGPIPCPGLQVESSCKVADAKSFSGPFNVLLVKTKWSNIGFHILLFDLESLLELLLPTPIRDVDPSNSFYCSEILRRAKSTVEKTTLTLKRNKTVCGPLSTEVHAKPVGESPAQGDNTIKLSEENDGVKKQKKIKSFKKMHPKQSRKVDANLTIDTAKLLLSCLLPWGVDKELDNLCIKHLNILKLQGPVSLGLAANEDHFSLMLPGWDLYNTEMKKDYSKVNLFSRKVLDLSDKYTSTFPNHSGMPKGLENNSDSLQESNTIVYLLSKLFLVNKLVNMPLELAYGMDSAFKIESVHNKMKSPGNDILNISSFYSYLRNGKSESHLPEADVSLLKLISCWRDQSVQVTEAIQAVLLAEVQKHMKTLRKTPVNSEPESVAKNGDYEMMQMLPKIEWAKEPELQCTTDTFPPQTPVSSVKHDSNSNSANFQDTEDMPDRCVLEESESPGKRKHHLWIEKVCSCKLC", "length": 1103, "header": "tr|E1BC63-1|E1BC63_BOVIN Isoform 1 of WD repeat domain 72 OS=Bos taurus OX=9913 GN=WDR72 PE=4 SV=4 CANONICAL=E1BC63-1" }, "locus": { "chromosome": "10", "start_pos": 56778260, "end_pos": 56582252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061231.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061231.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053754.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053754.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BC63", "url": "https://www.uniprot.org/uniprotkb/E1BC63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "E1BC63", "url": "https://www.uniprot.org/uniprotkb/E1BC63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" }, { "start_pos": 731, "end_pos": 733, "annotation": "n_glycosylation_sequon" }, { "start_pos": 790, "end_pos": 792, "annotation": "n_glycosylation_sequon" }, { "start_pos": 881, "end_pos": 883, "annotation": "n_glycosylation_sequon" }, { "start_pos": 891, "end_pos": 893, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" }, { "start_pos": 948, "end_pos": 950, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC63-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1103, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC63-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC63" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC63" }, { "id": "PF12894", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12894" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Anaphase-promoting complex subunit 4-like WD40", "eco_id": "ECO_0000259", "start_pos": 529, "end_pos": 597, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BC63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC63" }, { "id": "PF23123", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23123" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WDR72-like alpha-solenoid", "eco_id": "ECO_0000259", "start_pos": 868, "end_pos": 1085, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 401, "end_pos": 403 }, { "start_pos": 45, "end_pos": 47 }, { "start_pos": 731, "end_pos": 733 }, { "start_pos": 790, "end_pos": 792 }, { "start_pos": 881, "end_pos": 883 }, { "start_pos": 891, "end_pos": 893 }, { "start_pos": 93, "end_pos": 95 }, { "start_pos": 948, "end_pos": 950 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9S2-1", "uniprot_ac": "E1B9S2", "uniprot_id": "E1B9S2_BOVIN", "mass": { "chemical_mass": 36011.0, "monoisotopic_mass": 36011.0 }, "refseq": { "ac": "NP_001179080", "name": "ankyrin repeat and SOCS box protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179080" }, "gene_names": [ { "name": "ASB7", "type": "recommended", "evidence": [ { "id": "E1B9S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ] }, { "name": "ASB7", "type": "synonym", "evidence": [ { "id": "NP_001179080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179080" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box protein 7", "type": "recommended", "evidence": [ { "id": "E1B9S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S2/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box protein 7", "type": "synonym", "evidence": [ { "id": "NP_001179080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179080" } ] } ], "function": [ { "annotation": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as LZTS1, PSRC1 and SUV39H1. The ECS(ASB7) complex acts as a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1: ASB7 is recruited to heterochromatin by CBX5 (HP1 alpha), where it associates with SUV39H1, promoting the ubiquitin-proteasome-mediated degradation of SUV39H1. During mitosis, ASB7 is phosphorylated and inactivated, allowing SUV39H1 activity. The ECS(ASB7) complex also plays a role in spindle dynamics and genome integrity by targeting the mitotic progression protein PSRC1 for proteasomal degradation in a cell cycle-dependent manner. Also participates in meiosis by mediating the proper attachment between kinetochores and microtubules.", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2#function" }, { "database": "UniProtKB", "id": "ARBA00094274", "url": "https://www.uniprot.org/uniprotkb/ARBA00094274#function" }, { "database": "UniProtKB", "id": "A0AAA9S750", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S750#function" }, { "database": "UniProtKB", "id": "A0AAA9TA37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA37#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB7", "url": "https://www.uniprot.org/uniprotkb/E1B9S2", "locus": { "chromosome": "21", "start_pos": 5969897, "end_pos": 6023292, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010514", "url": "https://www.ensembl.org/id/ENSBTAG00000010514" } ] } } ], "crossref": [ { "id": "E1B9S2", "url": "https://alphafold.ebi.ac.uk/entry/E1B9S2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010514", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010514", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03726", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03726", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507483", "url": "https://www.ncbi.nlm.nih.gov/gene/507483", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507483", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507483", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CNGWTLL", "url": "https://omabrowser.org/oma/group/CNGWTLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9S2", "url": "https://www.orthodb.org/?gene=E1B9S2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S750", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S750", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S750-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S750-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9S2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9S2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 318, "header": "tr|E1B9S2-1|E1B9S2_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 7 OS=Bos taurus OX=9913 GN=ASB7 PE=3 SV=1 CANONICAL=E1B9S2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S750-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S750/entry", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTSGDTEAQKRDLLTQVQPAY", "length": 291, "header": "tr|A0AAA9S750-1|E1B9S2_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box protein 7 OS=Bos taurus OX=9913 GN=ASB7 PE=3 SV=1 CANONICAL=E1B9S2-1" }, "locus": { "chromosome": "21", "start_pos": 6012981, "end_pos": 5971431, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120547.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120547.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081031.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081031.1" } ] } }, { "isoform_ac": "A0AAA9SYY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYY7/entry", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGGQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 116, "header": "tr|A0AAA9SYY7-1|E1B9S2_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box protein 7 OS=Bos taurus OX=9913 GN=ASB7 PE=3 SV=1 CANONICAL=E1B9S2-1" }, "locus": { "chromosome": "21", "start_pos": 6012981, "end_pos": 5970901, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089498.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089498.1" } ] } }, { "isoform_ac": "A0AAA9TA37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA37/entry", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTMCLDFLHLLQSRQHIIYNRWYAEAGL", "length": 298, "header": "tr|A0AAA9TA37-1|E1B9S2_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box protein 7 OS=Bos taurus OX=9913 GN=ASB7 PE=3 SV=1 CANONICAL=E1B9S2-1" }, "locus": { "chromosome": "21", "start_pos": 6012981, "end_pos": 5979177, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120361.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120361.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093740.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093740.1" } ] } }, { "isoform_ac": "E1B9S2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9S2/entry", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 318, "header": "tr|E1B9S2-1|E1B9S2_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 7 OS=Bos taurus OX=9913 GN=ASB7 PE=3 SV=1 CANONICAL=E1B9S2-1" }, "locus": { "chromosome": "21", "start_pos": 6012981, "end_pos": 5970901, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013884.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013884.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013884.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013884.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507483", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507483", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZVT6-1", "protein_name": "Ankyrin repeat and SOCS box protein 7", "gene_name": "Asb7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVRILLDHSANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQDVTNSVSPLGLGRRLSCSVCPASMETSISLDKQHPDKAGHGSVLL", "length": 314 }, "evidence": [ { "id": "E1B9S2", "url": "https://omabrowser.org/oma/group/E1B9S2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F2Z5S9-1", "protein_name": "Ankyrin repeat and SOCS box protein 7", "gene_name": "ASB7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 318 }, "evidence": [ { "id": "E1B9S2", "url": "https://omabrowser.org/oma/group/E1B9S2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H597-1", "protein_name": "Ankyrin repeat and SOCS box protein 7", "gene_name": "Asb7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 318 }, "evidence": [ { "id": "E1B9S2", "url": "https://omabrowser.org/oma/group/E1B9S2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q91ZU0-1", "protein_name": "Ankyrin repeat and SOCS box protein 7", "gene_name": "Asb7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQDVTRQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 318 }, "evidence": [ { "id": "E1B9S2", "url": "https://omabrowser.org/oma/group/E1B9S2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H672-1", "protein_name": "Ankyrin repeat and SOCS box protein 7", "gene_name": "ASB7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI", "length": 318 }, "evidence": [ { "id": "E1B9S2", "url": "https://omabrowser.org/oma/group/E1B9S2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" }, { "name": "regulation of heterochromatin organization", "id": "GO:0120261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120261", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" }, { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1B9S2", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9S2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 318, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9S2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9S2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9S2" }, { "id": "PS50225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000259", "start_pos": 273, "end_pos": 313, "start_aa": "Arg", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 192, "end_pos": 194 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B738-1", "uniprot_ac": "E1B738", "uniprot_id": "E1B738_BOVIN", "mass": { "chemical_mass": 76004.0, "monoisotopic_mass": 76004.0 }, "refseq": { "ac": "NP_001179508", "name": "SHC SH2 domain-binding protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179508" }, "gene_names": [ { "name": "SHCBP1", "type": "recommended", "evidence": [ { "id": "E1B738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B738" } ] }, { "name": "SHCBP1", "type": "synonym", "evidence": [ { "id": "NP_001179508", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179508" } ] } ], "protein_names": [ { "name": "SHC SH2 domain-binding protein 1", "type": "recommended", "evidence": [ { "id": "E1B738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B738/entry#names_and_taxonomy" } ] }, { "name": "SHC SH2 domain-binding protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179508", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179508" } ] } ], "function": [ { "annotation": "May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.", "evidence": [ { "database": "UniProtKB", "id": "E1B738", "url": "https://www.uniprot.org/uniprotkb/E1B738#function" }, { "database": "UniProtKB", "id": "ARBA00060052", "url": "https://www.uniprot.org/uniprotkb/ARBA00060052#function" }, { "database": "UniProtKB", "id": "A0AAA9S859", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S859#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B738", "url": "https://www.uniprot.org/uniprotkb/E1B738" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHCBP1", "url": "https://www.uniprot.org/uniprotkb/E1B738", "locus": { "chromosome": "18", "start_pos": 14881869, "end_pos": 14921740, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033441", "url": "https://www.ensembl.org/id/ENSBTAG00000033441" } ] } } ], "crossref": [ { "id": "E1B738", "url": "https://alphafold.ebi.ac.uk/entry/E1B738", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033441", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033441", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523367", "url": "https://www.ncbi.nlm.nih.gov/gene/523367", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523367", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523367", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FLCESQD", "url": "https://omabrowser.org/oma/group/FLCESQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B738", "url": "https://www.orthodb.org/?gene=E1B738", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14695:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14695:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179508", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S859", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S859", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S859-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S859-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B738", "url": "https://www.uniprot.org/uniprotkb/E1B738", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B738-1", "url": "https://www.uniprot.org/uniprotkb/E1B738-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGLLAGGGLGSEAMAPEPELPGWATDEELERLEKGLFENEDSCSDCSDRAKPGSSLQSFVPEGKTHFPEMFQTSQLLFYERFRAYQDYILADCKASEVKEFTAEFLEKVLEPSGWRAVWQTNVFEVLVEVTDVDFAALKAVVRLADPYLCESQVSAFTLECMKELLDLKEYRLPLQELWVVFDDSGLFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYQNLLTQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGIRPNGRKITHVVSSTMMTGLLQSLLRDRLCPEPCKEEIEIQFHSDPLSAINASYEGDTVIVCPGHYVVHGAFSIADSIELEGYGLPDDIVIEKKGKGDTFVDCTGADIKISSMKFVQHDAVEGILIIHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSKCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNVIHNNEGYGVVLVKPTIFSDLQEDAQDETEENKALKVQTSGEADVAERVDLEELIQCATGKMELYARAELSEQVEGNCEIVNELVAASTQKGQMKKKRLSELGITQADDNLMSQEMFVSIVGNQFKWNGKGSFGTFLF", "length": 674, "header": "tr|E1B738-1|E1B738_BOVIN Isoform 1 of SHC SH2 domain-binding protein 1 OS=Bos taurus OX=9913 GN=SHCBP1 PE=4 SV=1 CANONICAL=E1B738-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S859-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S859/entry", "sequence": { "sequence": "MRQEGGPGEQGPRGHRRKDYGAGVLDGLFENEDSCSDCSDRAKPGSSLQSFVPEGKTHFPEMFQTSQLLFYERFRAYQDYILADCKASEVKEFTAEFLEKVLEPSGWRAVWQTNVFEVLVEVTDVDFAALKAVVRLADPYLCESQVSAFTLECMKELLDLKEYRLPLQELWVVFDDSGLFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYQNLLTQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGIRPNGRKITHVVSSTMMTGLLQSLLRDRLCPEPCKEEIEIQFHSDPLSAINASYEGDTVIVCPGHYVVHGAFSIADSIELEGYGLPDDIVIEKKGKGDTFVDCTGADIKISSMKFVQHDAVEGILIIHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSKCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNVIHNNEGYGVVLVKPTIFSDLQEDAQDETEENKALKVQTSGEADVAERVDLEELIQCATGKMELYARAELSEQVEGNCEIVNELVAASTQKGQMKKKRLSELGITQADDNLMSQEMFVSIVGNQFKWNGKGSFGTFLF", "length": 664, "header": "tr|A0AAA9S859-1|E1B738_BOVIN Computationally mapped isoform of SHC SH2 domain-binding protein 1 OS=Bos taurus OX=9913 GN=SHCBP1 PE=4 SV=1 CANONICAL=E1B738-1" }, "locus": { "chromosome": "18", "start_pos": 14921691, "end_pos": 14882291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119562.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119562.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078338.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078338.1" } ] } }, { "isoform_ac": "E1B738-1", "url": "https://www.uniprot.org/uniprotkb/E1B738/entry", "sequence": { "sequence": "MAEGLLAGGGLGSEAMAPEPELPGWATDEELERLEKGLFENEDSCSDCSDRAKPGSSLQSFVPEGKTHFPEMFQTSQLLFYERFRAYQDYILADCKASEVKEFTAEFLEKVLEPSGWRAVWQTNVFEVLVEVTDVDFAALKAVVRLADPYLCESQVSAFTLECMKELLDLKEYRLPLQELWVVFDDSGLFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYQNLLTQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGIRPNGRKITHVVSSTMMTGLLQSLLRDRLCPEPCKEEIEIQFHSDPLSAINASYEGDTVIVCPGHYVVHGAFSIADSIELEGYGLPDDIVIEKKGKGDTFVDCTGADIKISSMKFVQHDAVEGILIIHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSKCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNVIHNNEGYGVVLVKPTIFSDLQEDAQDETEENKALKVQTSGEADVAERVDLEELIQCATGKMELYARAELSEQVEGNCEIVNELVAASTQKGQMKKKRLSELGITQADDNLMSQEMFVSIVGNQFKWNGKGSFGTFLF", "length": 674, "header": "tr|E1B738-1|E1B738_BOVIN Isoform 1 of SHC SH2 domain-binding protein 1 OS=Bos taurus OX=9913 GN=SHCBP1 PE=4 SV=1 CANONICAL=E1B738-1" }, "locus": { "chromosome": "18", "start_pos": 14919115, "end_pos": 14882291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047558.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047558.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044758.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044758.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523367", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523367", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K2J0-1", "protein_name": "SHC SH2 domain-binding protein 1", "gene_name": "Shcbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADDLQAGVVLEPDAMVPPRPELAAEEEPASWKEGLFQDTDPCSDCGYHANPGATVKTLMPEGKILFPQIIQTNELLFYERFRAYQDYILADCKASEVKEFTVSFLEKVLEPSGWWAVWHTNVFEVLVEVTNVDFAALKAVVKLAEPCIYESKLSTFTLANVKELLDLKEFHLPLQELWVVSDDSHEVHQMALAIEHVRFFYKNIWRSWDEEEEDEYDYFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSSCNSDSEQENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGTRQNGQKVIHVVSSTMKTGLLRSLFRDRFCEESCKEETEIQFHSDLLSGINACYDGDTVIVCPGHYVVHGTCCIADSIELEGYGPPDDIIIEKRGKGDTFVDCTGMDVKISGVKFIQHDSVEGILIIHHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNGIHHCKEGILIKDFLDEHYDIPKISMINNVIHNNEGYGVVLVKPTIFCDLLEHAQDETNDNTVQKNKEADVTEGLDLEEMLQCVSNKMEPYATADFNEQAKGNCEIINELLAISMQKGRMKKRLSELGIVQADDDLMSQEMFIEIVGNQFKWNGKGSFGTFLY", "length": 668 }, "evidence": [ { "id": "E1B738", "url": "https://omabrowser.org/oma/group/E1B738/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZUM9-1", "protein_name": "SHC SH2 domain-binding protein 1", "gene_name": "SHCBP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGLGLPGGSEAGLQEGAEEAKPAPTQEDEDACSDYGSRDKPGSALGRAVPDGSVLFPDIFRTDHLLFYERFKAYQDYILADCKASEVKEFTAEYLEKVLEPSGWQAVWRTNVFEVLVEVVDVEYSALKAVVQLCEPFLCESQVSTFTLECMQELLELKERRIPLQELWVVYDESGDFDQTALAVEHVRFFYECIWRTWDEEEEDDFDYFVRCVEPRLRLHYDILEHRVPSGLVADYHNYLSQCEELYRKFLNVRNNISSSDSDSEMENVSMVEGLKLYEKVEHLKQKLKLIENPLLRYVFGYQKYSGLQAKGQRPTGIKITHVVSSTVMASLLQSLIRDKLCPESCGEELEIQFHNDPLAAVNACYEGDTVIICPGHYVVDGMFCIADSIEIEGYGLPDDIVIEKQGKGDNFVDCTGANIKISNLKLVQHDAVEGILNVHQGKTTLENCVLQCETTGITVRTSAELLMKNSDLYGAKGAGVEIYPGSTCTLLDNGIHHCKEGILIKNFLDEHFDIPKISMANNMIHNNEGYGVVLVKPTVASDVKDASAEGTTGYAQSTQSSDERAHEEGFREELPECVADELELYKQAEISEGNHEIVSELGAASAKKSQMHRKRLSELGITEADDNLMSQEMFVSIVGNQFKWNGKGSFGTFLF", "length": 657 }, "evidence": [ { "id": "E1B738", "url": "https://omabrowser.org/oma/group/E1B738/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I3N1-1", "protein_name": "SHC SH2 domain-binding protein 1", "gene_name": "Shcbp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGELPGSSLLEPGVMVPASAALAAEEDPASRQEGLFQDADPCSDHSCHTEPDATEQTLVPEGKIIFPQIIQTNELLFYERFRAYQDYILADCKASEVKEFTISFLEKALEPSGWWAVWHTNVFEVLVEVTNVDFSALKAVVRLAEPCIYESKLSTFTLANVKELLDLKEFQLPLQELWVVSDGSHESHQMALAIEHVRFFYKNIWRSWDEEEEDEYDYFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSDCHSDSEQENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGPRENSQKVTHVVSSTMKTGLLRSLFRDRFSEEPCKEETEIQFHSDLLSAVNACHEGDTVIICPGHYVVHGTCSIADSIELEGYGLPDDIVIEKKGKGDTFVDCTGMDVKISSIKFIQHDSVEGILIIHHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNEIHHCKEGILIKDFLDEHYDIPKISMINNIIHNNEGYGVVLVKPTIFCDLQENAQDETAGNTTQKNREAGATEGLDLEEMLQCVANKMELSSTADFSEQAKGNCEIINELLATSMQKGRMKKRLSELGIIQADDNIMSQEMFIEIMGNQFKWNGKGSFGTFLY", "length": 668 }, "evidence": [ { "id": "E1B738", "url": "https://omabrowser.org/oma/group/E1B738/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8NEM2-1", "protein_name": "SHC SH2 domain-binding protein 1", "gene_name": "SHCBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFMPEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWHTNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWVVFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNEGYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCARTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFKWNGKGSFGTFLF", "length": 672 }, "evidence": [ { "id": "E1B738", "url": "https://omabrowser.org/oma/group/E1B738/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VIP0-1", "protein_name": "Protein nessun dorma", "gene_name": "nesd", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEVFTFEKSYLERLKEAEAVLSWEGAVMPASQVRSEWKSYVELKIEPAGWQAIWKIPRVICEDLKLRYPTIVYGYVEQVIFDELKAVFVVTAVQDSDVHLPESNEVSLVELWPTVQQENAALNVDTTAECIDRLRFFYTHVWMPWDKDYDDDRDWVQQHLQARIQLVCDLSKNRLPRPLALHMRTLLAEAKYIQQRLDYLELDLSDAESDDEAVELNDSVAEPARKQSKAGSANGCLNVSSLPVTDLMCLHLRMAIIRSEFEILENPEMRRAYSELQSNSLKRLRCSSGRTRQSEDLLVERNSISHVVTLPGKLQQQLELLKLAQTLVKPESKVQLSNTLQDVLSICQSNDDILLSPGEHTIKFLEHLNDNGSLRGLTQPEAILSPAADLSLLPVVCSSDEDSTLLVIDGDYTLSELVLDCRHVRRGILLRNGTLTMRGCRLLGDGSSSTQEGIVCMPGASVELKSCLIENFAVGVSMRPKSSAELGSVQFKTCKTGLELLEKSASVNLQGSKCSFENCALGILADGFVLGEQRTEKVLVLNKFSELQRYNEDNLLGNCSFYNCKKNVRVFNESGQLLAQRSHQQLLEDELGGENKENIQLV", "length": 602 }, "evidence": [ { "id": "E1B738", "url": "https://omabrowser.org/oma/group/E1B738/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z179-1", "protein_name": "SHC SH2 domain-binding protein 1", "gene_name": "Shcbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADDLRAGGVLEPIAMVPPRPDLAAEKEPASWKEGLFLDADPCSDQGYHANPGATVKTLIPEGKTPFPRIIQTNELLFYERFRAYQDYILADCKASEVKEFTVSFLEKVLEPSGWWAVWHTNVFEVLVEVTNVDFPSLKAVVRLAEPCIYESKLSTFTLANVKELLDLKEFHLPLQELWVVSDDSHEFHQMALAIEHVRFFYKHIWRSWDEEEEDEYDYFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQGKGTRQNGQKVIHVVSSTMKTGLLRSLFKDRFCEESCKEETEIKFHSDLLSGINACYDGDTVIICPGHYVVHGTCSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGMDVKISGIKFIQHDSVEGILIIHHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNGIHHCKEGILIKDFLDEHYDIPKISMINNVIHNNEGYGVVLVKPTIFCDLQENTQDEINDNMVQKNKEADVTEGLDLEEMLQCVASKMEPYATADFNEQAKGNCEIINELLAISMQKGRMKKRLSELGITQADDNIMSQEMFIEIMGNQFKWNGKGSFGTFLY", "length": 668 }, "evidence": [ { "id": "E1B738", "url": "https://omabrowser.org/oma/group/E1B738/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1B738", "url": "https://www.uniprot.org/uniprotkb/E1B738" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "E1B738", "url": "https://www.uniprot.org/uniprotkb/E1B738" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "E1B738", "url": "https://www.uniprot.org/uniprotkb/E1B738" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B738-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 674, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B738-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B738" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B738" }, { "id": "PF13229", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13229" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Right handed beta helix", "eco_id": "ECO_0000259", "start_pos": 434, "end_pos": 548, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B738" }, { "id": "PF23762", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23762" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SHC SH2", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 310, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 281, "end_pos": 283 }, { "start_pos": 376, "end_pos": 378 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB72-1", "uniprot_ac": "E1BB72", "uniprot_id": "E1BB72_BOVIN", "mass": { "chemical_mass": 31728.0, "monoisotopic_mass": 31728.0 }, "refseq": {}, "gene_names": [ { "name": "RAD1", "type": "recommended", "evidence": [ { "id": "E1BB72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ] } ], "protein_names": [ { "name": "Cell cycle checkpoint protein RAD1", "type": "recommended", "evidence": [ { "id": "E1BB72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB72/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72#function" }, { "database": "UniProtKB", "id": "ARBA00055414", "url": "https://www.uniprot.org/uniprotkb/ARBA00055414#function" }, { "database": "UniProtKB", "id": "A0AAA9S953", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S953#function" }, { "database": "UniProtKB", "id": "A0ABI0NV97", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV97#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAD1", "url": "https://www.uniprot.org/uniprotkb/E1BB72", "locus": { "chromosome": "20", "start_pos": 39236701, "end_pos": 39227867, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019209", "url": "https://www.ensembl.org/id/ENSBTAG00000019209" } ] } } ], "crossref": [ { "id": "E1BB72", "url": "https://alphafold.ebi.ac.uk/entry/E1BB72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019209", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019209", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00577", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00577", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BB72", "url": "https://www.orthodb.org/?gene=E1BB72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10870:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10870:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-176187", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5685938", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685938", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5693607", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69473", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S953", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S953", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S953-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S953-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NV97", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NV97-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB72-1", "url": "https://www.uniprot.org/uniprotkb/E1BB72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLLTQRIPDENDYCLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFRVQEESVTFRINLTVLLDCLSIFGSSPVPGTFTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMELFHCNETQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPDSSS", "length": 281, "header": "tr|E1BB72-1|E1BB72_BOVIN Isoform 1 of Cell cycle checkpoint protein RAD1 OS=Bos taurus OX=9913 GN=RAD1 PE=3 SV=2 CANONICAL=E1BB72-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S953-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S953/entry", "sequence": { "sequence": "MPLLTQRIPDENDYCLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFRVQEESVTFRINLTVLLDCLSIFGSSPVPVFVSIAGTFTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMELFHCNETQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPDS", "length": 285, "header": "tr|A0AAA9S953-1|E1BB72_BOVIN Computationally mapped isoform of Cell cycle checkpoint protein RAD1 OS=Bos taurus OX=9913 GN=RAD1 PE=3 SV=1 CANONICAL=E1BB72-1" }, "locus": { "chromosome": "20", "start_pos": 39234620, "end_pos": 39228578, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114427.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114427.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082599.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082599.1" } ] } }, { "isoform_ac": "A0ABI0NV97-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV97/entry", "sequence": { "sequence": "MPLLTQRIPDENDYCLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFRVQEESVTFRINLTVLLDCLSIFGSSPVPGTFTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMELFHCNETQVNRSVGCHLVMKYMIRNEDGQICFVEYYCCPDEEVPDS", "length": 256, "header": "tr|A0ABI0NV97-1|A0ABI0NV97_BOVIN Computationally mapped isoform of Cell cycle checkpoint protein RAD1 OS=Bos taurus OX=9913 GN=RAD1 PE=3 SV=1 CANONICAL=E1BB72-1" }, "locus": { "chromosome": "20", "start_pos": 39234620, "end_pos": 39228578, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147795.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147795.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104146.1" } ] } }, { "isoform_ac": "E1BB72-1", "url": "https://www.uniprot.org/uniprotkb/E1BB72/entry", "sequence": { "sequence": "MPLLTQRIPDENDYCLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFRVQEESVTFRINLTVLLDCLSIFGSSPVPGTFTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMELFHCNETQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPDSSS", "length": 281, "header": "tr|E1BB72-1|E1BB72_BOVIN Isoform 1 of Cell cycle checkpoint protein RAD1 OS=Bos taurus OX=9913 GN=RAD1 PE=3 SV=2 CANONICAL=E1BB72-1" }, "locus": { "chromosome": "20", "start_pos": 39234629, "end_pos": 39228578, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025568.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025568.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025568.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025568.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-176187", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "resource": "Reactome", "description": "Activation of ATR in response to replication stress" }, { "id": "R-BTA-5685938", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685938", "resource": "Reactome", "description": "HDR through Single Strand Annealing (SSA)" }, { "id": "R-BTA-5693607", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "resource": "Reactome", "description": "Processing of DNA double-strand break ends" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" }, { "id": "R-BTA-69473", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "resource": "Reactome", "description": "G2/M DNA damage checkpoint" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "meiotic recombination checkpoint signaling", "id": "GO:0051598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051598", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" }, { "name": "checkpoint clamp complex", "id": "GO:0030896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030896", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BB72", "url": "https://www.uniprot.org/uniprotkb/E1BB72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB72-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 281, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB72-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB72" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 25, "end_pos": 27 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8F6-1", "uniprot_ac": "E1B8F6", "uniprot_id": "E1B8F6_BOVIN", "mass": { "chemical_mass": 103951.0, "monoisotopic_mass": 103951.0 }, "refseq": {}, "gene_names": [ { "name": "PEX6", "type": "recommended", "evidence": [ { "id": "E1B8F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ] } ], "protein_names": [ { "name": "Peroxisomal ATPase PEX6", "type": "recommended", "evidence": [ { "id": "E1B8F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F6/entry#names_and_taxonomy" } ] }, { "name": "Peroxin-6", "type": "synonym", "evidence": [ { "id": "E1B8F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F6/entry#names_and_taxonomy" } ] }, { "name": "Peroxisomal biogenesis factor 6", "type": "synonym", "evidence": [ { "id": "E1B8F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6#function" }, { "database": "UniProtKB", "id": "ARBA00057209", "url": "https://www.uniprot.org/uniprotkb/ARBA00057209#function" }, { "database": "UniProtKB", "id": "A0AAA9S9G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PEX6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6", "locus": { "chromosome": "23", "start_pos": 16575504, "end_pos": 16625004, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005532", "url": "https://www.ensembl.org/id/ENSBTAG00000005532" } ] } } ], "crossref": [ { "id": "E1B8F6", "url": "https://alphafold.ebi.ac.uk/entry/E1B8F6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005532", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005532", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19481", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19481", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057605", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057605", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8F6", "url": "https://www.orthodb.org/?gene=E1B8F6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23077", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23077", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23077:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23077:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25394", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25394", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25395", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25395", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T137", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T137", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T137-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T137-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8F6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8F6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALAVLRVLEPFPTETPALAVLLPPGGPWPAAGLGLVLALRPAGESPAGPALLVAALEGPGAGTEEQGPGPPQLLVSRALLQLLALGSGAWVRARPVRRPPSLGWALLGTSSGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRAKLGPEAENSSRLPLPPVVSSFAASGTVRRLRGVLGGTGDALGVSRSCLRSLSLFQGEWVWVTRAGESSNTSQPHLATVQVLEPRWNLSERLGPGSGQPGEPLADGLALVPATLAFNLGCDPLDVGELKIQRYLEGSSTPEDKGSCSVLPGPPFAKELHIEIVSSPHYSTNGNYDHVLYRHFQTPRAVQEGDVLCVPTVGQVEILEASPEKLPRWQEMFFKVKRTVGEAPDGQARAYLADSAHTSLYLVGSTLSLVPRLPSGDSTPWSSLSPPGLEALVTELCTALKPRLQPGGALLTGTGSVLLRGPPGSGKTTAVAAACSRLGLHLLKVPCSSLCADSSGAVETKLQAAFSRARRCRPVVLLLTAVDLLGRDRDGLGEDARVVATLRHLLLDEDPLASCPPLMVVATTSRAQDLPADVQTAFPHELEVPVLAEAQRLSVLRALTAHLPLGQEVNLAQLARRCAGFVVGDLFALLTHSSRAACTRIKNSGWAGGLSEEDEGELCAAGFPLLAEDFGQALEQLQAAHSQAIGAPRIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLRCVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPNRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGVNEDRASQLRVLSAITRKFRLEPSVSLVDVLDHCPPQLTGADLYSLCSDAMTAALKRRVRDLEEGLEPGSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC", "length": 981, "header": "tr|E1B8F6-1|E1B8F6_BOVIN Isoform 1 of Peroxisomal ATPase PEX6 OS=Bos taurus OX=9913 GN=PEX6 PE=3 SV=2 CANONICAL=E1B8F6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G0/entry", "sequence": { "sequence": "MALAVLRVLEPFPTETPALAVLLPPGGPWPAAGLGLVLALRPAGESPAGPALLVAALEGPGAGTEEQGPGPPQLLVSRALLQLLALGSGAWVRARPVRRPPSLGWALLGTSSGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRAKLGPEAENSSRLPLPPVVSSFAASGTVRRLRGVLGGTGDALGVSRSCLRSLSLFQGEWVWVTRAGESSNTSQPHLATVQVLEPRWNLSERLGPGSGQPGEPLADGLALVPATLAFNLGCDPLDVGELKIQRYLEGSSTPEDKGSCSVLPGPPFAKELHIEIVSSPHYSTNGNYDHVLYRHFQTPRAVQEGDVLCVPTVGQVEILEASPEKLPRWQEMFFKVKRTVGEAPDGQARAYLADSAHTSLYLVGSTLSLVPRLPSGDSTPWSSLSPPGLEALVTELCTALKPRLQPGGALLTGTGSVLLRGPPGSGKTTAVAAACSRLGLHLLKVPCSSLCADSSGAVETKLQAAFSRARRCRPVVLLLTAVDLLGRDRDGLGEDARVVATLRHLLLDEDPLASCPPLMVVATTSRAQDLPADVQTAFPHELEVPVLAEAQRLSVLRALTAHLPLGQEVNLAQLARRCAGFVVGDLFALLTHSSRAACTRIKNSGWAGGLSEEDEGELCAAGFPLLAEDFGQALEQLQAAHSQAIGAPRIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPNRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGVNEDRASQLRVLSAITRKFRLEPSVSLVDVLDHCPPQLTGADLYSLCSDAMTAALKRRVRDLEEGLEPGSSALLLTMEDLLQAAHSQAIGAPRIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAA", "length": 1061, "header": "tr|A0AAA9S9G0-1|E1B8F6_BOVIN Computationally mapped isoform of Peroxisomal ATPase PEX6 OS=Bos taurus OX=9913 GN=PEX6 PE=3 SV=1 CANONICAL=E1B8F6-1" }, "locus": { "chromosome": "23", "start_pos": 16624941, "end_pos": 16577201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135374.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135374.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081925.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081925.1" } ] } }, { "isoform_ac": "A0AAA9T137-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T137/entry", "sequence": { "sequence": "MALAVLRVLEPFPTETPALAVLLPPGGPWPAAGLGLVLALRPAGESPAGPALLVAALEGPGAGTEEQGPGPPQLLVSRALLQLLALGSGAWVRARPVRRPPSLGWALLGTSSGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRAKLGPEAENSSRLPLPPVVSSFAASGTVRRLRGVLGGTGDALGVSRSCLRSLSLFQGEWVWVTRAGESSNTSQPHLATVQVLEPRWNLSERLGPGSGQPGEPLADGLALVPATLAFNLGCDPLDVGELKIQRYLEGSSTPEDKGSCSVLPGPPFAKELHIEIVSSPHYSTNGNYDHVLYRHFQTPRAVQEGDVLCVPTVGQVEILEASPEKLPRWQEMFFKVKRTVGEAPDGQARAYLADSAHTSLYLVGSTLSLVPRLPSGDSTPWSSLSPPGLEALVTELCTALKPRLQPGGALLTGTGSVLLRGPPGSGKTTAVAAACSRLGLHLLKVPCSSLCADSSGAVETKLQAAFSRARRCRPVVLLLTAVDLLGRDRDGLGEDARVVATLRHLLLDEDPLASCPPLMVVATTSRAQDLPADVQTAFPHELEVPVLAEAQRLSVLRALTAHLPLGQEVNLAQLARRCAGFVVGDLFALLTHSSRAACTRIKNSGWAGGLSEEDEGELCAAGFPLLAEDFGQALEQLQAAHSQAIGAPRIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPNRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRSRELGPAAHHGGPAAGRGPAAALGQRAGVAPVQAHPTQVCRLLGAPCSLGPAHRGSRRSGRPKANARPPECCLPPGNPLVLSAIRSPR", "length": 951, "header": "tr|A0AAA9T137-1|E1B8F6_BOVIN Computationally mapped isoform of Peroxisomal ATPase PEX6 OS=Bos taurus OX=9913 GN=PEX6 PE=3 SV=1 CANONICAL=E1B8F6-1" }, "locus": { "chromosome": "23", "start_pos": 16624941, "end_pos": 16611076, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107404.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107404.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091414.1" } ] } }, { "isoform_ac": "E1B8F6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8F6/entry", "sequence": { "sequence": "MALAVLRVLEPFPTETPALAVLLPPGGPWPAAGLGLVLALRPAGESPAGPALLVAALEGPGAGTEEQGPGPPQLLVSRALLQLLALGSGAWVRARPVRRPPSLGWALLGTSSGPGLGPRVGPLLVRRGETLPVPGPRVLETRPALQGLLGPGTRLAVTELRGRAKLGPEAENSSRLPLPPVVSSFAASGTVRRLRGVLGGTGDALGVSRSCLRSLSLFQGEWVWVTRAGESSNTSQPHLATVQVLEPRWNLSERLGPGSGQPGEPLADGLALVPATLAFNLGCDPLDVGELKIQRYLEGSSTPEDKGSCSVLPGPPFAKELHIEIVSSPHYSTNGNYDHVLYRHFQTPRAVQEGDVLCVPTVGQVEILEASPEKLPRWQEMFFKVKRTVGEAPDGQARAYLADSAHTSLYLVGSTLSLVPRLPSGDSTPWSSLSPPGLEALVTELCTALKPRLQPGGALLTGTGSVLLRGPPGSGKTTAVAAACSRLGLHLLKVPCSSLCADSSGAVETKLQAAFSRARRCRPVVLLLTAVDLLGRDRDGLGEDARVVATLRHLLLDEDPLASCPPLMVVATTSRAQDLPADVQTAFPHELEVPVLAEAQRLSVLRALTAHLPLGQEVNLAQLARRCAGFVVGDLFALLTHSSRAACTRIKNSGWAGGLSEEDEGELCAAGFPLLAEDFGQALEQLQAAHSQAIGAPRIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLRCVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPNRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGVNEDRASQLRVLSAITRKFRLEPSVSLVDVLDHCPPQLTGADLYSLCSDAMTAALKRRVRDLEEGLEPGSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC", "length": 981, "header": "tr|E1B8F6-1|E1B8F6_BOVIN Isoform 1 of Peroxisomal ATPase PEX6 OS=Bos taurus OX=9913 GN=PEX6 PE=3 SV=2 CANONICAL=E1B8F6-1" }, "locus": { "chromosome": "23", "start_pos": 16624941, "end_pos": 16611213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007275.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007275.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007275.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007275.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein import into peroxisome matrix, translocation", "id": "GO:0016561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016561", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein unfolding", "id": "GO:0043335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043335", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein targeting to peroxisome", "id": "GO:0006625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006625", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein import into peroxisome matrix, receptor recycling", "id": "GO:0016562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016562", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "peroxisome organization", "id": "GO:0007031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007031", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein import into peroxisome matrix", "id": "GO:0016558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016558", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ubiquitin-modified protein reader activity", "id": "GO:0140036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140036", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "protein transporter activity", "id": "GO:0140318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140318", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B8F6", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8F6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 981, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8F6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8F6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F6" }, { "id": "SM00382", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AAA+ ATPase", "eco_id": "ECO_0000259", "start_pos": 462, "end_pos": 597, "start_aa": "Gly", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 250, "end_pos": 252 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8R9-1", "uniprot_ac": "E1B8R9", "uniprot_id": "E1B8R9_BOVIN", "mass": { "chemical_mass": 49612.0, "monoisotopic_mass": 49612.0 }, "refseq": { "ac": "NP_001179828", "name": "5-phosphohydroxy-L-lysine phospho-lyase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179828" }, "gene_names": [ { "name": "PHYKPL", "type": "recommended", "evidence": [ { "id": "E1B8R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R9" } ] }, { "name": "AGXT2L2", "type": "synonym", "evidence": [ { "id": "NP_001179828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179828" } ] }, { "name": "PHYKPL", "type": "synonym", "evidence": [ { "id": "NP_001179828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179828" } ] } ], "protein_names": [ { "name": "5-phosphohydroxy-L-lysine phospho-lyase", "type": "synonym", "evidence": [ { "id": "NP_001179828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179828" }, { "id": "E1B8R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R9/entry#names_and_taxonomy" } ] }, { "name": "alanine-glyoxylate aminotransferase 2-like 2", "type": "synonym", "evidence": [ { "id": "NP_001179828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179828" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8R9", "url": "https://www.uniprot.org/uniprotkb/E1B8R9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHYKPL", "url": "https://www.uniprot.org/uniprotkb/E1B8R9", "locus": { "chromosome": "7", "start_pos": 39286822, "end_pos": 39312396, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013628", "url": "https://www.ensembl.org/id/ENSBTAG00000013628" } ] } } ], "crossref": [ { "id": "E1B8R9", "url": "https://alphafold.ebi.ac.uk/entry/E1B8R9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013628", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013628", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00610", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00610", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537241", "url": "https://www.ncbi.nlm.nih.gov/gene/537241", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005814", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005814", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537241", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537241", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "REGLNQH", "url": "https://omabrowser.org/oma/group/REGLNQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8R9", "url": "https://www.orthodb.org/?gene=E1B8R9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45688", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45688", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45688:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45688:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00202", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00202", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-71064", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71064", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179828", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T285", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T285", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T285-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T285-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8R9", "url": "https://www.uniprot.org/uniprotkb/E1B8R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8R9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAADQRGKAATLALRRRLLSNSCRLFFPEDPIKIVRGQGQYMYDEQGAEYIDCINNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEKLCVFYFLNSGSEANDLALRLARQYTGHWDVVVLDHAYHGHLSSLIDISPYKFRDLDGQKEWVHVAPLPDTYRGPYREDHPNPAVAYASEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFPEVAGHIRRAGGVFVADEIQVGFGRVGKHFWAFQLQGEDFVPDIVTMGKSIGNGHPVACVATTQAVARAFEATGVEYFNTFGGSPVSCAVGLAVLDVLEKEQLQAHAACVGSFLMELLGQQKAKHPILGDIRGVGLFIGVDLIKDEATRMPATEEADYVVSRLKENYILLSTDGPGRNVLKFKPPMCFSLDNARHVVAKLDAILTDMEAKVRSCETLRLHS", "length": 450, "header": "tr|E1B8R9-1|E1B8R9_BOVIN Isoform 1 of 5-phosphohydroxy-L-lysine phospho-lyase OS=Bos taurus OX=9913 GN=PHYKPL PE=3 SV=1 CANONICAL=E1B8R9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X3/entry", "sequence": { "sequence": "VQRQRRGGGAYDVRTSGAEPADLSSAGSRPAPEPTAPETLRHSACGRRSLPAPPPQRLIHPRSCSRASGKTSPSGGPLSGPGAGQTVTQEGIKSPDERSEANDLALRLARQYTGHWDVVVLDHAYHGHLSSLIDISPYKFRDLDGQKEWVHVAPLPDTYRGPYREDHPNPAVAYASEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFPEVAGHIRRAGGVFVADEIQVGFGRVGKHFWAFQLQGEDFVPDIVTMGKSIGNGHPVACVATTQAVARAFEATGVEYFNTFGGSPVSCAVGLAVLDVLEKEQLQAHAACVGSFLMELLGQQKAKHPILGDIRGVGLFIGVDLIKDEATRMPATEEADYVVSRLKENYILLSTDGPGRNVLKFKPPMCFSLDNARHVVAKLDAILTDMEAKVRSCETLRLHS", "length": 435, "header": "tr|A0AAA9S9X3-1|E1B8R9_BOVIN Computationally mapped isoform of 5-phosphohydroxy-L-lysine phospho-lyase OS=Bos taurus OX=9913 GN=PHYKPL PE=3 SV=1 CANONICAL=E1B8R9-1" }, "locus": { "chromosome": "7", "start_pos": 39312061, "end_pos": 39287525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109978.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109978.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080223.1" } ] } }, { "isoform_ac": "A0AAA9T285-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T285/entry", "sequence": { "sequence": "MAADQRGKAATLALRRRLLSNSCRLFFPEDPIKIVRGQGQYMYDEQGAEYIDCINNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEKLCVFYFLNSGSEANDLALRLARQYTGHWDVVVLDHAYHGHLSSLIDISPYKFRDLDGQKEWVHVAPLPDTYRGPYREDHPNPAVAYASEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFPEVAGHIRRAGGVFVADEIQVGFGRVGKHFWAFQLQGEDFVPDIVTMGKSIGNGHPVACVATTQAVARAFEATGVEYFNTFGGSPVSCAVGLAVLDVLEKEQLQAHAACVGSFLMELLGQQKAKHPILGDIRGVGLFIGVDLIKDEATRMPATEEADYVVSSPCLLSAEAHPPACPPVLAGSLRTQELRMISGKEGASSSAKPDCLHLATTPLCTTPPAPCSFFS", "length": 454, "header": "tr|A0AAA9T285-1|E1B8R9_BOVIN Computationally mapped isoform of 5-phosphohydroxy-L-lysine phospho-lyase OS=Bos taurus OX=9913 GN=PHYKPL PE=3 SV=1 CANONICAL=E1B8R9-1" }, "locus": { "chromosome": "7", "start_pos": 39312120, "end_pos": 39289139, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122344.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122344.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090526.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090526.1" } ] } }, { "isoform_ac": "E1B8R9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R9/entry", "sequence": { "sequence": "MAADQRGKAATLALRRRLLSNSCRLFFPEDPIKIVRGQGQYMYDEQGAEYIDCINNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEKLCVFYFLNSGSEANDLALRLARQYTGHWDVVVLDHAYHGHLSSLIDISPYKFRDLDGQKEWVHVAPLPDTYRGPYREDHPNPAVAYASEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFPEVAGHIRRAGGVFVADEIQVGFGRVGKHFWAFQLQGEDFVPDIVTMGKSIGNGHPVACVATTQAVARAFEATGVEYFNTFGGSPVSCAVGLAVLDVLEKEQLQAHAACVGSFLMELLGQQKAKHPILGDIRGVGLFIGVDLIKDEATRMPATEEADYVVSRLKENYILLSTDGPGRNVLKFKPPMCFSLDNARHVVAKLDAILTDMEAKVRSCETLRLHS", "length": 450, "header": "tr|E1B8R9-1|E1B8R9_BOVIN Isoform 1 of 5-phosphohydroxy-L-lysine phospho-lyase OS=Bos taurus OX=9913 GN=PHYKPL PE=3 SV=1 CANONICAL=E1B8R9-1" }, "locus": { "chromosome": "7", "start_pos": 39312120, "end_pos": 39287525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018115.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018115.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018115.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018115.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537241", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537241", "resource": "KEGG Pathway" }, { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-71064", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71064", "resource": "Reactome", "description": "Lysine catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BCJ7-1", "protein_name": "5-phosphohydroxy-L-lysine phospho-lyase", "gene_name": "PHYKPL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAADPREKAATLALRRRLLSNSCKLFFPEDPIKIVRGQGQYMYDEEGAEYIDCINNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEKLCVFYFLNSGSEANDLALRLARQYTGHWDVVVLDHAYHGHLSSLIDISPYKFRDLDGQKEWVHVAPLPDTYRGLYREDHPNPAVAYASEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIVPPAGFFPEVAEHIHKAGGVFVADEIQVGFGRVGKHFWAFQLQGEDFVPDIVTMGKSIGNGHPVACVATTQAVARAFEATGVEYFNTFGGSPVSCAVGLAVLDVLEKEQLQAHAACVGSFLMELLRQQKAKHPILGDIRGVGLFIGVDLIKDEATRMPATEEADYVVSRLKENYILLSTDGPGRNVLKFKPPMCFSLDNARHVVAKLDTILTDMEEKVRSCKTLRRVL", "length": 450 }, "evidence": [ { "id": "E1B8R9", "url": "https://omabrowser.org/oma/group/E1B8R9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8J8XD81-1", "protein_name": "5-phosphohydroxy-L-lysine phospho-lyase", "gene_name": "Phykpl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAADRRAKAATLDLRRRLLSSSCRLFFPENPVKIIRGQGQYLYDEQGREYLDCINNVAHVGHCHPTVVQAAHEQNLVLNTNSRYLHDNIVDYAQRLSETLPEKLSVFYFLNSGSEANDLALRLARQYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLDGQKEWVHVAPLPDTYRGPYREDHPDPAGAYASEVKHVISSAQKKGRKIAAFFAESLPSVSGQIIPPAGYFSQVAEHIRRAGGLFVADEIQVGFGRVGKHFWAFQLEGEDFVPDIVTMGKSIGNGHPVACLATTQAVSRAFEATGVEYFNTFGGNPVSCAVGLAVLDVLKTEQLQAHATNVGSFLMEHLSQQKAKHPIIGDVRGTGLFIGVDLIKDETLRTPATEEAEYLVSRLKENYILLSTDGPGRNILKFKPPMCFSLDNAQHVVAKLDDILTDMEEKVRSCETLRIKHPPGSTGPGCRAAAGSRPSNLEQGNLVIKSAP", "length": 481 }, "evidence": [ { "id": "E1B8R9", "url": "https://omabrowser.org/oma/group/E1B8R9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YK70-1", "protein_name": "5-phosphohydroxy-L-lysine phospho-lyase", "gene_name": "PHYKPL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRRAQRSRQETLTLRRQLIGSSCKLFYPNDPLKIVKARGQYMYDENGRQYLDCINNVAHVGHCHPDVVKAAHEQNQLLNTNSRYLHDNLTDYAERLSEKLPEKLCTFYFLNSGSEANDLALRMARQFTKHEDVIVLDHAYHGHLTSLIDISPYKFRNLEGQKEWVHVAPVPDTYRGLYREDHEDPATAYATEVKNIIERAHKKGREIAAFFAESLPSVGGQIIPPEGYFQKVAEHVHKAGGVFVADEIQVGFGRVGKHFWAFQLQGEEFIPDIVTMGKPIGNGHPIACVATTKEIAEAFAATGVEYFNTFGGNPVSCAIGLAVLDVIEKEQLQIHATEVGNFLMKLLTEQKVKHPIIGDVRGSGLFIGVDLIKDQAKRTPATEEAEYLITRLKEEYILLSTDGPGRNVLKFKPPMCFTMEDAKFVVDTIDKLLTDMEKEHMNQEKTSTGST", "length": 451 }, "evidence": [ { "id": "E1B8R9", "url": "https://omabrowser.org/oma/group/E1B8R9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q1ZXC3-1", "protein_name": "Aminotransferase class-III", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MITRGVIKNIKTTSVLINNSIKSTQCSFSSKVNYDEIYKKHLKISEKKFNKKEIIQTIKDNTLFSWNPTEAAANKALIMEKGEGVYFYDTDGKKYIDFNSQAMCSNLGHTVPEEVIKAIEEQLRSAAYAYPCSIVTPIKAKLSMLLADLFPGDINHFYYTSGGAESNETAMRMARLFTGRHKILARYRSYHGATLGAMTLTGDPRRWNSEPGASGVVHFMDPYPYSFKWGETEEQITEISLKYLRETISYEGAKNIAAIFIEPVTGTNGILKPPKGYLEGIRKICDETGILMVCDEVMNGFGRTGEMFGFMNSQEEVIPDIVTMAKGINGAYLPLGAVGCRDRIADHFKVNPIGIGSTYNSHPVTLASAYAALQYFLKNRVLDNVKTLEPVMKKHMEQLKQRHPTVKGYRSLGLFGIVELQKNSNGDPFIEYNGPPHPAMTKLSSDFVENGLYTLCRWSSFFTNPPLTINEKELKEGFEILDKSLTNLDKHFEK", "length": 494 }, "evidence": [ { "id": "E1B8R9", "url": "https://omabrowser.org/oma/group/E1B8R9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8IUZ5-1", "protein_name": "5-phosphohydroxy-L-lysine phospho-lyase", "gene_name": "PHYKPL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEQLCVFYFLNSGSEANDLALRLARHYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLDGQKEWVHVAPLPDTYRGPYREDHPNPAMAYANEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFGRVGKHFWAFQLQGKDFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATGVEYFNTFGGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQKIKHPIVGDVRGVGLFIGVDLIKDEATRTPATEEAAYLVSRLKENYVLLSTDGPGRNILKFKPPMCFSLDNARQVVAKLDAILTDMEEKVRSCETLRLQP", "length": 450 }, "evidence": [ { "id": "E1B8R9", "url": "https://omabrowser.org/oma/group/E1B8R9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R1K4-1", "protein_name": "5-phosphohydroxy-L-lysine phospho-lyase", "gene_name": "Phykpl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAADTRAKAVTLDLRRRLLSSSCRLFFPEDPVKIIRGQGQYLYDEQGREYLDCINNVAHVGHCHPTVVQAAHEQNLVLNTNSRYLHDNIVDYAQRLSETLPEQLSVFYFLNSGSEANDLALRLARQYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLGGQKEWVHVAPLPDTYRGPYREDHPNPAEAYANEVKHVISSAQQKGRKIAAFFAESLPSVSGQIIPPAGYFSQVAEHIHRAGGLFVADEIQVGFGRIGKHFWAFQLEGEDFVPDIVTMGKSIGNGHPVACMATTQAVSRAFEATGVEYFNTFGGNPVSCAVGLAVLDVLKTEQLQAHATNVGSFLLEHLTQQKAKHPIIGDVRGTGLFIGVDLIKDETLRTPATEEAEYLVSRLKENYILLSIDGPGKNILKFKPPMCFNVDNAQHVVAKLDDILTDMEEKVRSCETLRIKHPPEDTHPTQILLTRQQD", "length": 467 }, "evidence": [ { "id": "E1B8R9", "url": "https://omabrowser.org/oma/group/E1B8R9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "E1B8R9", "url": "https://www.uniprot.org/uniprotkb/E1B8R9" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1B8R9", "url": "https://www.uniprot.org/uniprotkb/E1B8R9" } ], "pmid": "" }, { "name": "lyase activity", "id": "GO:0016829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016829", "evidence": [ { "database": "UniProtKB", "id": "E1B8R9", "url": "https://www.uniprot.org/uniprotkb/E1B8R9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8R9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 450, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8R9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8R9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7X4-1", "uniprot_ac": "E1B7X4", "uniprot_id": "E1B7X4_BOVIN", "mass": { "chemical_mass": 38767.0, "monoisotopic_mass": 38767.0 }, "refseq": { "ac": "NP_001341256", "name": "SERTA domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341256" }, "gene_names": [ { "name": "SERTAD4", "type": "recommended", "evidence": [ { "id": "E1B7X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X4" } ] }, { "name": "SERTAD4", "type": "synonym", "evidence": [ { "id": "NP_001341256", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341256" } ] } ], "protein_names": [ { "name": "SERTA domain containing 4", "type": "synonym", "evidence": [ { "id": "E1B7X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X4/entry#names_and_taxonomy" } ] }, { "name": "SERTA domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001341256", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341256" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7X4", "url": "https://www.uniprot.org/uniprotkb/E1B7X4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERTAD4", "url": "https://www.uniprot.org/uniprotkb/E1B7X4", "locus": { "chromosome": "16", "start_pos": 73094210, "end_pos": 73105682, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010850", "url": "https://www.ensembl.org/id/ENSBTAG00000010850" } ] } } ], "crossref": [ { "id": "E1B7X4", "url": "https://alphafold.ebi.ac.uk/entry/E1B7X4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010850", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010850", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614583", "url": "https://www.ncbi.nlm.nih.gov/gene/614583", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614583", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614583", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSHQVDY", "url": "https://omabrowser.org/oma/group/CSHQVDY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7X4", "url": "https://www.orthodb.org/?gene=E1B7X4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14272", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14272", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14272:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14272:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001341256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341256", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7X4", "url": "https://www.uniprot.org/uniprotkb/E1B7X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7X4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7X4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGLSPPGPAQAPLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSCSHKTISIFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIIMQNNWCFPACSFNGASAQEWFMAQDCPYRKRPRMAKEECEKFHACCLYQECGGHYLNLPLSVNANVGSASTTASSSSPSSSSSSSPPLPLPSCSQQVDFDIGSAPVYKGDGQIPASEIFVTNVRSLGVQEKAKLNDEKVNDDTNRDGGPLSHGPVGNDLAFEGKGQFYDYFETGYNEKSNVSESWKKSLRKKEPSPSNKLCCSKGSKI", "length": 352, "header": "tr|E1B7X4-1|E1B7X4_BOVIN Isoform 1 of SERTA domain containing 4 OS=Bos taurus OX=9913 GN=SERTAD4 PE=4 SV=1 CANONICAL=E1B7X4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE4/entry", "sequence": { "sequence": "MPHHHHPQGLDNAAAVGRWGGKDGGCQERAFARKRKSYLRLSEMTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGLSPPGPAQAPLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSCSHKTISIFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIIMQNNWCFPACSFNGASAQEWFMAQDCPYRKRPRMAKEECEKFHACCLYQECGGHYLNLPLSVNANVGSASTTASSSSPSSSSSSSPPLPLPSCSQQVDFDIGSAPVYKGDGQIPASEIFVTNVRSLGVQEKAKLNDEKVNDDTNRDGGPLSHGPVGNDLAFEGKGQFYDYFETGYNEKSNVSESWKKSLRKKEPSPSNKLCCSKGSKI", "length": 395, "header": "tr|A0AAA9SAE4-1|E1B7X4_BOVIN Computationally mapped isoform of SERTA domain containing 4 OS=Bos taurus OX=9913 GN=SERTAD4 PE=4 SV=1 CANONICAL=E1B7X4-1" }, "locus": { "chromosome": "16", "start_pos": 73105022, "end_pos": 73095963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083061.1" } ] } }, { "isoform_ac": "E1B7X4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7X4/entry", "sequence": { "sequence": "MTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGLSPPGPAQAPLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSCSHKTISIFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIIMQNNWCFPACSFNGASAQEWFMAQDCPYRKRPRMAKEECEKFHACCLYQECGGHYLNLPLSVNANVGSASTTASSSSPSSSSSSSPPLPLPSCSQQVDFDIGSAPVYKGDGQIPASEIFVTNVRSLGVQEKAKLNDEKVNDDTNRDGGPLSHGPVGNDLAFEGKGQFYDYFETGYNEKSNVSESWKKSLRKKEPSPSNKLCCSKGSKI", "length": 352, "header": "tr|E1B7X4-1|E1B7X4_BOVIN Isoform 1 of SERTA domain containing 4 OS=Bos taurus OX=9913 GN=SERTAD4 PE=4 SV=1 CANONICAL=E1B7X4-1" }, "locus": { "chromosome": "16", "start_pos": 73100342, "end_pos": 73095963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014402.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014402.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014402.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014402.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614583", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614583", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M1PS78-1", "protein_name": "SERTA domain-containing protein 4 isoform X1", "gene_name": "sertad4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALVLSMNPFCEPETESPPPIFQPIWESEHCSKSCVSNPSPPGGEPQGLMEEPHYRRAPDHVMNRVAVSRISYFKRKFVEDEEPVLSFRSYCHTQVSPVLEERAHILRLSLEKLRFMDDPESFLRRSVLINNLLRRLRNEILLQSDWCFPSGPTTTPCPLQTPAANTSLSPPALQPCITPPGSYRKRLRLMRKEGPECVPACCCLYAAGRYLQLPLSVYEREVYSNSHPSSSTSSSSSSSSSVRFPQLMEDEDEEDSDDEEEDSVCPVLAMCQAETREQNRTWDSLRSQSHRDDKILEKEREKGKERVKGGEVSQRWLSDTIGTRHHGTLARAHIRGK", "length": 338 }, "evidence": [ { "id": "E1B7X4", "url": "https://omabrowser.org/oma/group/E1B7X4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Z9C3-1", "protein_name": "SERTA domain containing 4", "gene_name": "SERTAD4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTLVLPMQRLGRPSAAEGTADLAAYRALWEPPACGRPGPAAPGPGPGPAPVAAGPPAAGSHYRGISNPAAASKIAYFKRKYVEEEDFHPPLSSCAHKTISVFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIVMQNNWCFSACSFGAASPQEWFVPQDCPYRKRLRMAKEEYEKLHTCCFYQECGSHYLNLPYSVNASTENTSSSSPSSSSSPISLPSCSQQVDYDIGSAPSYRSDEQIPASEIFVTNARPHANQDKAKFTDEKGGDEPERDDVPLNCEPVRGTHAFECKGKFYDYFETGCNDKSDVSESWKKSLRKKESLPSNKMCCSKGSKI", "length": 345 }, "evidence": [ { "id": "E1B7X4", "url": "https://omabrowser.org/oma/group/E1B7X4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LNP9-1", "protein_name": "SERTA domain containing 4", "gene_name": "Sertad4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "KNGQGVWAGCGERFVRCSPCHGRAARVGSGLRAGAARAAPRAEAERGRRQGGRGRGAPRSGRAEGGGERACQVPSRPGGIQQSQARKSAGKWQTGLTGFSRSSPDTAAHFHNRLRRRRDLRGPRPPRTGPRRQGPGGAWAAAAARRTAAAGAQGARFCEPIVSEGAAEIAGYHTLWEADSYGGASPPGPAHVPSQGDRGAGPQLAGSHYRGISNPVSTPKVTYFKRKYAEEEELPTPLSSCSHKTISIFEERAHILYMSLEKLRFIDDPEVYLRRSVLINNLMKRIHGEIVMQNSWYLPACSLSGTSAQEWFLAQDCPYRKRPRVAKQEWEKFHTCCFYQECGGHCLNLPLSVSDGVGSASAAAVASPASSSSSPSTSSPSSPSSSSSSLSSPLPLPSCSHHVDFDVGSAPIYKSQVPASEIFVTNVRSLGVQEKIKFNSDGKVSHETSRDGNALGQEPVGNDLDFECKGQFYDYFETGYTERNRMSESWKKSLRKKELSPSNKLCCSRGGKM", "length": 513 }, "evidence": [ { "id": "E1B7X4", "url": "https://omabrowser.org/oma/group/E1B7X4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A7DTG3-1", "protein_name": "SERTA domain-containing protein 4", "gene_name": "Sertad4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGASPPGPAPVPSQGDRGASSHLAGSHYRGIPNPISTPKVTYFKRKYAEDEDLHPPLSSCSHKTISIFEERAHILYMSLEKLRFIDDPEVYLRRSVLINNLMKRIHGEIVMQNSWCLPACSLGGTPAQEWFLAQDCPYRKRPRVAKEEWEKIHTCCFYQECGGHCLNLPLSVNTSVGSTSAAAVASAASSSSSPSTSSSSSPSSSSSPSPSPSSSSSSSSSSPLPLPSCSHHVDFDIGSAPIYKSQIPASEIFVTNIRSLGVQEKVKFNNDGKVSHETSRDGDALGQEPVGNDLDFECKGQFYDYFETGYNERNRVSESWKKSLRKKELSPSSKLCCNRGGKM", "length": 377 }, "evidence": [ { "id": "E1B7X4", "url": "https://omabrowser.org/oma/group/E1B7X4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3LUP4-1", "protein_name": "SERTA domain containing 4", "gene_name": "SERTAD4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGPSPPGPAQAPLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSCSHKTISIFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIIMQNNWCFPACSFNGASAQEWFMAQDCPYRKRPRMAKEECEKFHACCFYQECGGHYLNLPLSVNANVGSASSSSSSSSSSSPSPPPPLPSCSHQVDFDVGSTPLYKGDGQIPANEIFVTNARSLGVQEKAKLNDEKADDDTSRDGGPLNHEPVGHDLAFECKGQFYDYFETGYNEKNNVSESWKKSIRKKEPSPSNKLCCSKGSKI", "length": 349 }, "evidence": [ { "id": "E1B7X4", "url": "https://omabrowser.org/oma/group/E1B7X4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9NUC0-1", "protein_name": "SERTA domain-containing protein 4", "gene_name": "SERTAD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGPSPPGPAQAPLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSCSHKTISIFEERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIIMQNNWCFPACSFNGTSAQEWFMAQDCPYRKRPRMAKEECEKFHACCFYQECGGHYLNLPLSVNANVGSASTAASSPSASSSSSSSSSSPPLPLPSCSRQVDFDVGSASIYKSDGQIPANEIFVTNVRSLGVQEKAKLNDEKANDDTNRDGGPLSHEPVGNDLAFECKGQFYDYFETGYNERNNVNESWKKSLRKKEASPPSNKLCCSKGSKI", "length": 356 }, "evidence": [ { "id": "E1B7X4", "url": "https://omabrowser.org/oma/group/E1B7X4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7X4", "url": "https://www.uniprot.org/uniprotkb/E1B7X4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7X4", "url": "https://www.uniprot.org/uniprotkb/E1B7X4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X4" }, { "id": "PS51053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SERTA", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 147, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 324, "end_pos": 326 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8U7-1", "uniprot_ac": "E1B8U7", "uniprot_id": "E1B8U7_BOVIN", "mass": { "chemical_mass": 40047.0, "monoisotopic_mass": 40047.0 }, "refseq": { "ac": "NP_001192921", "name": "RCC1 domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192921" }, "gene_names": [ { "name": "RCCD1", "type": "recommended", "evidence": [ { "id": "E1B8U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U7" } ] }, { "name": "RCCD1", "type": "synonym", "evidence": [ { "id": "NP_001192921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192921" } ] } ], "protein_names": [ { "name": "RCC1 domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1B8U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U7/entry#names_and_taxonomy" } ] }, { "name": "RCC1 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001192921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192921" } ] } ], "function": [ { "annotation": "Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.", "evidence": [ { "database": "UniProtKB", "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7#function" }, { "database": "UniProtKB", "id": "ARBA00054503", "url": "https://www.uniprot.org/uniprotkb/ARBA00054503#function" }, { "database": "UniProtKB", "id": "A0AAA9TSX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSX0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RCCD1", "url": "https://www.uniprot.org/uniprotkb/E1B8U7", "locus": { "chromosome": "21", "start_pos": 21704343, "end_pos": 21712970, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018642", "url": "https://www.ensembl.org/id/ENSBTAG00000018642" } ] } } ], "crossref": [ { "id": "E1B8U7", "url": "https://alphafold.ebi.ac.uk/entry/E1B8U7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018642", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018642", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531926", "url": "https://www.ncbi.nlm.nih.gov/gene/531926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531926", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531926", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PSWSMEI", "url": "https://omabrowser.org/oma/group/PSWSMEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8U7", "url": "https://www.orthodb.org/?gene=E1B8U7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46849:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46849:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00415", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00415", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9629569", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629569", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192921", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEERRGTWFGFGFCGFGQALGSGLGRQVHSPEPLRTPGGSLGVCRVSASWSYTAFVTRGGQVQLSGAAGGTADGCTDAWASEELLVLLRAGPGAGAELQAWAPGSAMRGDPLWSQAVQEAEHGPSRDETQAGLLPLLPCARAYVSPRPPFYRPLAPTLRARRLELGAEHALLLDAAGQVFSWGAGRHGQLGHGTLEAEPEPRLLEALQGLRMAEVAAGGWHSVCLSETGDIYIWGWNESGQLALPTKSLAEDGKTTAGEASGLEEDGSEVKRGSAGEDGAPAPFIAVQPFPALLDLSPGSEAVKVSCGSRHTAVLTRTGELYTWGWGKYGQLGHKDTTTLDRPCRVEYFVDKQLQVRTVSCGPWNTYVYAVEKEKS", "length": 377, "header": "tr|E1B8U7-1|E1B8U7_BOVIN Isoform 1 of RCC1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=RCCD1 PE=4 SV=3 CANONICAL=E1B8U7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE5/entry", "sequence": { "sequence": "MDEERRGTWFGFGFCGFGQALGSGLGRQVHSPEPLRTPGGSLGVCRVSASWSYTAFVTRGGQVQLSGAAGGTADGCTDAWASEELLVLLRAGPGAGAELQAWAPGSAMRGDPLWSQAVQEAEHGPSRDETQAGLLPLLPCARAYVSPRPPFYRPLAPTLRARRLELGAEHALLLDAAGQVFSWGAGRHGQLGHGTLEAEPEPRLLEALQGLRMAEVAAGGWHSVCLSASGLEEDGSEVKRGSAGEDGAPAPFIAVQPFPALLDLSPGSEAVKVSCGSRHTAVLTRTGELYTWGWGKYGQLGHKDTTTLDRPCRVEYFVDKQLQVRTVSCGPWNTYVYAVEKEKS", "length": 344, "header": "tr|A0AAA9SAE5-1|E1B8U7_BOVIN Computationally mapped isoform of RCC1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=RCCD1 PE=4 SV=1 CANONICAL=E1B8U7-1" }, "locus": { "chromosome": "21", "start_pos": 21711411, "end_pos": 21705843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111989.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111989.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080876.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080876.1" } ] } }, { "isoform_ac": "A0AAA9TSX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSX0/entry", "sequence": { "sequence": "MMHLEFSLLPLSVLLPACVRAAAASRKGSSETISPDSCPNPPSRRPRQPGRSQPRALRGMDEERRGTWFGFGFCGFGQALGSGLGRQVHSPEPLRTPGGSLGVCRVSASWSYTAFVTRGGQVQLSGAAGGTADGCTDAWASEELLVLLRAGPGAGAELQAWAPGSAMRGDPLWSQAVQEAEHGPSRDETQAGLLPLLPCARAYVSPRPPFYRPLAPTLRARRLELGAEHALLLDAAGQVFSWGAGRHGQLGHGTLEAEPEPRLLEALQGLRMAEVAAGGWHSVCLSETGDIYIWGWNESGQLALPTKSLAEDGKTTAGEASGLEEDGSEVKRGSAGEDGAPAPFIAVQPFPALLDLSPGSEAVKVSCGSRHTAVLTRTGELYTWGWGKYGQLGHKDTTTLDRPCRVEYFVDKQLQVRTVSCGPWNTYVYAVEKEKS", "length": 436, "header": "tr|A0AAA9TSX0-1|E1B8U7_BOVIN Computationally mapped isoform of RCC1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=RCCD1 PE=4 SV=1 CANONICAL=E1B8U7-1" }, "locus": { "chromosome": "21", "start_pos": 21711922, "end_pos": 21705843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097718.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097718.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100442.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100442.1" } ] } }, { "isoform_ac": "E1B8U7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U7/entry", "sequence": { "sequence": "MDEERRGTWFGFGFCGFGQALGSGLGRQVHSPEPLRTPGGSLGVCRVSASWSYTAFVTRGGQVQLSGAAGGTADGCTDAWASEELLVLLRAGPGAGAELQAWAPGSAMRGDPLWSQAVQEAEHGPSRDETQAGLLPLLPCARAYVSPRPPFYRPLAPTLRARRLELGAEHALLLDAAGQVFSWGAGRHGQLGHGTLEAEPEPRLLEALQGLRMAEVAAGGWHSVCLSETGDIYIWGWNESGQLALPTKSLAEDGKTTAGEASGLEEDGSEVKRGSAGEDGAPAPFIAVQPFPALLDLSPGSEAVKVSCGSRHTAVLTRTGELYTWGWGKYGQLGHKDTTTLDRPCRVEYFVDKQLQVRTVSCGPWNTYVYAVEKEKS", "length": 377, "header": "tr|E1B8U7-1|E1B8U7_BOVIN Isoform 1 of RCC1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=RCCD1 PE=4 SV=3 CANONICAL=E1B8U7-1" }, "locus": { "chromosome": "21", "start_pos": 21711411, "end_pos": 21705843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024803.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024803.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024803.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024803.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 58, "start_aa": "Thr", "end_pos": 58, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr58", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531926", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531926", "resource": "KEGG Pathway" }, { "id": "R-BTA-9629569", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629569", "resource": "Reactome", "description": "Protein hydroxylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5K1URH4-1", "protein_name": "RCC1 domain-containing protein 1", "gene_name": "RCCD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGERPGAWFGFGFCGFGQALGSGRGRQVYSPEPLEVPGASLDVCRVSASWSYTATVTRGGRLELSGSVSGSAGGCRDAWASEALLVVLRAGTGSDSGAELQAWAPGSSLRGEPLWAQTVVLEVERKDGPGGDETQAGPLPLLPCASAYVSPQPPFYRPLAPTLRARRLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEREPRVLEALQGLPMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPARSLAEDGKTITGDAPGLNEDGSEAKRATEGEDGGPTPFIAVQPFPALLDLPLGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHKDTTSLDRPCRVEYFVDKQLQVRTVSCGPWNTYVFAVEKEKSRHM", "length": 385 }, "evidence": [ { "id": "E1B8U7", "url": "https://omabrowser.org/oma/group/E1B8U7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LYV3-1", "protein_name": "RCC1 domain containing 1", "gene_name": "Rccd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEKRQGAWFGFGFCGFGQALGSGNGQHAVHSPEPLHAADDVCQVSASWSYTALVTRGGRVELSGSVSCAADGCRDVWASEGLLVVQRNKSGSGTELQAWVPGSALQGEPLWVQNLASGAKAQGEDEPGSEPRMGTLPLLPCARAYMTPQPPFCQPLAPELRVRQLQLGAEHALLLCEAGQVFSWGGGRHGQLGHGSLEAELEPRLLEALQGLRMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRSGTEKKTVREEELNDDGLRGEEAALADVGAPAHFIAIQPFPALLDLPLGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHKDSTSSDQPCRVEYFVERQLEVRAVTCGPWNTYVYAVERENI", "length": 376 }, "evidence": [ { "id": "E1B8U7", "url": "https://omabrowser.org/oma/group/E1B8U7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6NED2-1", "protein_name": "RCC1 domain-containing protein 1", "gene_name": "RCCD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS", "length": 376 }, "evidence": [ { "id": "E1B8U7", "url": "https://omabrowser.org/oma/group/E1B8U7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BTU7-1", "protein_name": "RCC1 domain-containing protein 1", "gene_name": "Rccd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEKRHGAWFGFGFCGFGQALGSGNSHHSVYSPEPLHASDDICQVSAGWSYTALVTRGGRVELSGSVSGAADGCRDVWASEELLVLLRNKGGSSTEVQAWVPGSALQGEPLWVQNLVSGAKGQGEDEPSRESRMGTLPLLPCARAYVTPEPPFCQPLAPELRVRQLELGAEHVLLLCAAGQVFSWGAGRHGQLGHGTLEAELEPRLLEALQGLRMAKVAAGGWHSVCLSETGDIYIWGWNESGQLALPTRSGTENKAEREEATELNEDGLKEELAVADAGAPAHFIAIQPFPALLDLPLGSDAVMASCGSRHTAVVTRTGELYTWGWGKYGQLGHKDSTSLDRPCCVEYFVERQLEVRAVTCGPWNTYVYAMERDKS", "length": 377 }, "evidence": [ { "id": "E1B8U7", "url": "https://omabrowser.org/oma/group/E1B8U7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "E1B8U7", "url": "https://www.uniprot.org/uniprotkb/E1B8U7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 58 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBQ1-1", "uniprot_ac": "E1BBQ1", "uniprot_id": "E1BBQ1_BOVIN", "mass": { "chemical_mass": 110618.0, "monoisotopic_mass": 110618.0 }, "refseq": { "ac": "XP_024848218", "name": "protein FAM186B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848218" }, "gene_names": [ { "name": "FAM186B", "type": "recommended", "evidence": [ { "id": "E1BBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1" } ] }, { "name": "FAM186B", "type": "synonym", "evidence": [ { "id": "XP_024848218", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848218" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 186 member B", "type": "synonym", "evidence": [ { "id": "E1BBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1/entry#names_and_taxonomy" } ] }, { "name": "protein FAM186B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024848218", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848218" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBQ1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM186B", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1", "locus": { "chromosome": "5", "start_pos": 30250542, "end_pos": 30224142, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019283", "url": "https://www.ensembl.org/id/ENSBTAG00000019283" } ] } } ], "crossref": [ { "id": "E1BBQ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BBQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019283", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019283", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505861", "url": "https://www.ncbi.nlm.nih.gov/gene/505861", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR049144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TMTVHSR", "url": "https://omabrowser.org/oma/group/TMTVHSR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBQ1", "url": "https://www.orthodb.org/?gene=E1BBQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33590", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33590", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33590:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33590:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20865", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20865", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20870", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20870", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848218", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848218", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBQ1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBQ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKDKPPQLVTPASVKAIISRIEAAQLTRAQENISSQLSEILDNVNCVINRFQEELGYDFKKKAKPPQPQQKGKNRFILLEKISSFSEDAKTKEKNLYEILHWLGDWGDSLTYEIKNRKSEEEEEALDEWIEVMEKVLPLSLIATKGGIESLISLCSTLIEGQRKGAQMSKHTFWQDWQEQSPQKAISCPQPLSPEQMLQDKHTTCVKVSEVKSMLQELLDSTMFNQGEVRAIRYMSAVVENLNKALILQHKENRSLEAKYRHLKIEMTKELSNQKLYFQKSLQVLESKRDALLKQIDILGGKYHDLLLIKHALEFQLKKIQSAGGQAEDLVRVLVEFPDPDKKEALPKKDTVMEETQQEPKKEEQFSPCSPSPMAMAWDSGAMPSPDQPLSTMTVDSRIADVYRSKDAESLQPVLPSSMDHMFPKKWERLSAESPGDRAKDQDFFQEVAWEKEGLQIKSHFQKQLSLERSRKLALESKAEAREEELSWERRRQQWQQEEEMWLQRQERWALLEQEHEEKLRQWEAEEAAREQRLRLDQEPRGPWREPEQPGEDAERMIFVPIIRWKDSEDASLAPPPSRAQSARQGRRPCVPRSPKAQQPIPRNQRSMSSAEFTQKPQAHRLPVKPKKSASFPVTGTSPRRVTQPPVHIAPVTRKEKVYHIDVEAQRRNLRLLTEEDTLGLPHYLHGKALELTTTTMELNALKLWCLFHKYICYRHFQSLRQDVINHIQVVREAGASYKAQNLFLFLENVDHLQKLQLQVWTDKQKDLEEKRRGCLSSMATMFPKLQEWNVNLHTPVVISPKSRKSKPPPFLLRHIHSSSPFCKRSQELFKTKHQPRVPQQMARQQGNQMEAMWKIDVAASSYPIEKKTPTSLSWDQLGGFPDIPRLLALDVQSSFHKSLMSLKARASVTQRKEEEEPPEESAELVHKKSNESFPGTLRSQKDRDNPSPIPCLSQ", "length": 956, "header": "tr|E1BBQ1-1|E1BBQ1_BOVIN Isoform 1 of Family with sequence similarity 186 member B OS=Bos taurus OX=9913 GN=FAM186B PE=4 SV=2 CANONICAL=E1BBQ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAE7/entry", "sequence": { "sequence": "MEKDKPPQLVTPASVKAIISRIEAAQLTRAQENISSQLSEILDNVNCVINRFQEELGYDFKKKAKPPQPQQKGKNRFILLEKISSFSEDAKTKEKNLYEILHWLGDWVSKHTFWQDWQEQSPQKAISCPQPLSPEQMLQDKHTTCVKVSEVKSMLQELLDSTMFNQGEVRAIRYMSAVVENLNKALILQHKENRSLEAKYRHLKIEMTKELSNQKLYFQKSLQVLESKRDALLKQIDILGGKYHDLLLIKHALEFQLKKIQSAGGQAEDLVRVLVEFPDPDKKEALPKKDTVMEETQQEPKKEEQFSPCSPSPMAMAWDSGAMPSPDQPLSTMTVDSRIADVYRSKDAESLQPVLPSSMDHMFPKKWERLSAESPGDRAKDQDFFQEVAWEKEGLQIKSHFQKQLSLERSRKLALESKAEAREEELSWERRRQQWQQEEEMWLQRQERWALLEQEHEEKLRQWEAEEAAREQRLRLDQEPRGPWREPEQPGEDAERMIFVPIIRWKDSEDASLAPPPSRAQSARQGRRPCVPRSPKAQQPIPRNQRSMSSAEFTQKPQAHRLPVKPKKSASFPVTGTSPRRVTQPPVHIAPVTRKEKVYHIDVEAQRRNLRLLTEEDTLGLPHYLHGKALELTTTTMELNALKLWCLFHKYICYRHFQSLRQDVINHIQVVREAGASYKAQNLFLFLENVDHLQKLQLQVWTDKQKDLEEKRRGCLSSMATMFPKLQEWNVNLHTPVVISPKSRKSKPPPFLLRHIHSSSPFCKRSQELFKTKHQPRVPQQMARQQGNQMEAMWKIDVAASSYPIEKKTPTSLSWDQLGGFPDIPRLLALDVQSSFHKSLMSLKARASVTQRKEEEEPPEESAELVHKKSNESFPGTLRSQKDRDNPSPIPCLSQ", "length": 895, "header": "tr|A0AAA9SAE7-1|E1BBQ1_BOVIN Computationally mapped isoform of Family with sequence similarity 186 member B OS=Bos taurus OX=9913 GN=FAM186B PE=4 SV=1 CANONICAL=E1BBQ1-1" }, "locus": { "chromosome": "5", "start_pos": 30249538, "end_pos": 30233506, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134836.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134836.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080409.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080409.1" } ] } }, { "isoform_ac": "E1BBQ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1/entry", "sequence": { "sequence": "MEKDKPPQLVTPASVKAIISRIEAAQLTRAQENISSQLSEILDNVNCVINRFQEELGYDFKKKAKPPQPQQKGKNRFILLEKISSFSEDAKTKEKNLYEILHWLGDWGDSLTYEIKNRKSEEEEEALDEWIEVMEKVLPLSLIATKGGIESLISLCSTLIEGQRKGAQMSKHTFWQDWQEQSPQKAISCPQPLSPEQMLQDKHTTCVKVSEVKSMLQELLDSTMFNQGEVRAIRYMSAVVENLNKALILQHKENRSLEAKYRHLKIEMTKELSNQKLYFQKSLQVLESKRDALLKQIDILGGKYHDLLLIKHALEFQLKKIQSAGGQAEDLVRVLVEFPDPDKKEALPKKDTVMEETQQEPKKEEQFSPCSPSPMAMAWDSGAMPSPDQPLSTMTVDSRIADVYRSKDAESLQPVLPSSMDHMFPKKWERLSAESPGDRAKDQDFFQEVAWEKEGLQIKSHFQKQLSLERSRKLALESKAEAREEELSWERRRQQWQQEEEMWLQRQERWALLEQEHEEKLRQWEAEEAAREQRLRLDQEPRGPWREPEQPGEDAERMIFVPIIRWKDSEDASLAPPPSRAQSARQGRRPCVPRSPKAQQPIPRNQRSMSSAEFTQKPQAHRLPVKPKKSASFPVTGTSPRRVTQPPVHIAPVTRKEKVYHIDVEAQRRNLRLLTEEDTLGLPHYLHGKALELTTTTMELNALKLWCLFHKYICYRHFQSLRQDVINHIQVVREAGASYKAQNLFLFLENVDHLQKLQLQVWTDKQKDLEEKRRGCLSSMATMFPKLQEWNVNLHTPVVISPKSRKSKPPPFLLRHIHSSSPFCKRSQELFKTKHQPRVPQQMARQQGNQMEAMWKIDVAASSYPIEKKTPTSLSWDQLGGFPDIPRLLALDVQSSFHKSLMSLKARASVTQRKEEEEPPEESAELVHKKSNESFPGTLRSQKDRDNPSPIPCLSQ", "length": 956, "header": "tr|E1BBQ1-1|E1BBQ1_BOVIN Isoform 1 of Family with sequence similarity 186 member B OS=Bos taurus OX=9913 GN=FAM186B PE=4 SV=2 CANONICAL=E1BBQ1-1" }, "locus": { "chromosome": "5", "start_pos": 30249538, "end_pos": 30233506, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025675.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025675.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025675.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025675.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3Z420-1", "protein_name": "Family with sequence similarity 186, member B", "gene_name": "Fam186b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKDNPPHLVTPTSVKAIISKIETAQLIRTQEDISTQLSDILDNVNCAINRFQEELGYDLKERAKPHQPEQKGKKRFILLEKLAAFSDDAKAKEKHLYEILHWLGEWGDSLTYEIKDRSSEEDEALDEWIEVMEKVLPLSLMATKGGIESLISLCSTLIEDQKKMTQRYKHNFWQDWHEKSPQNKEQGIPVPPSPEQMLQDKNTAHLNVSEVRSMLQELLDSTMFNKGEVKAIRYMSAVVENLNKALTLQHKENKSLETKYKYLQVEKNKELSTQRLHFQKSIQVLESKRDALLKQVKILGDKYHHLLMLKHTLEFQLNIAQPASGPEEPTKHFIHYLEPPEKEPLPGQGTALEKEKQEPKEKGQAVSALFSSPLTKAWHSGTTPAAPKPIFGTDTDSRVRDVFVDRTEALEPVLLHSEVPQIPTQWEKLGDMKDKDQGDHIQEEGAQSKSLSPGSIRRRLLESHMGHWEEELNWETRRQQWLQEEEMWLQRQKKWALLEQEHQEKVRQWEAEAAARQQWQRLTQPEEEKPSPRKEQKASSEMIFTTTSRWKSLKKSESTPTPHCRAQSAHQSRSYILASPHTQQPGQGTQRTLGSAEFLQRPPTRQVSAKPKKSTSLPVTGTSILRRVSQVSLQQAPGTPKDKVYHIDMEAQLKNLQVLGGSESEVALPQYLRSKALEVIAIAMDLSILRLQYLCKKYIQYRRFQSLRLEMIKHIGAIRQTRVTSKAQNLYLFLENIDHQQSLRLQAWADKQRDLEERHQECLHTMVAMFPKLQQEWNVHLSVPVLTHVKPVKSKSSSVLLQRVRSSHSTTKHRPPPKPRESVPLPITGQQGSQMEAIWKADVASSSHPIEKKTPTNMCWEQLGGYPDIPRLLVVDEHPSCPRSSVSFKARSFSASSVQRKEGQEPSEELAGPVCKMSSQSLPGSICTKQEGSGSSSTHSIP", "length": 943 }, "evidence": [ { "id": "E1BBQ1", "url": "https://omabrowser.org/oma/group/E1BBQ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D4ADP4-1", "protein_name": "Family with sequence similarity 186, member B", "gene_name": "Fam186b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKDDPTHLVTPTSVKAIISKIETAQLIRTQEDISAQLSDILDNVNCAINRFQEELGYDLKEKVRPHQPEQKGRKRFILLEKIASFSKDAIAKEKHLYEILHWLGEWGDSLTYEIKNGRSSEEDDALDEWIEVMEKVLPLSLMATKGGIESLISLCSTLIEDQKKRTQMYKHNFWQDWHEKSPQKEEQGLRPEPPSPEQMLQDRNTTRLKVSEVRSMLQELLDSTLFNKGEVRAIRYMSAVVENLNKALVLQHKENRTLETKYKHLQVEMNKELSTQRLHFQKSIQVLESKRDALLNQVKVLGDKYHNLLMIKHALEFQLKMVQTNPEEPIMSFVDGIELPEKETLPEVGTALRKKQQESKKEGWGLSALSPCLLTKAWDSGTTPAAQKPPSGVAADSRTEDAVADHSESLEPVLLHSEVPQIPMQWEKLVEKEGKDQGDHTQGKEGVQSKSLSPGSTRRMLVESHTGHWEEELNWETRRQQWVQEEEMWLRRQKKWALLEQEHQEKVRQWEAEAAARQQWQRLTQPEEEKQSPRKEQKASSEKRIFTTTSRWKNLEKSESPTAPPHCRAQSARHLLTPPHAQQQGPGMQKTPCSVETPRARQVSAKPKKCASFPITGTSIRRVTRTSSQKALGTPKDKVYHIDMEAQLKNLQILGSSESELLLPQYLHSKALEVTSMAMELNTLRLQSLCKKYIHYRRFQSLRQEVIKHIGALRQTRVTYKAQNLYVFLENIDRLQSLRLQAWTDKQKDLEERYQECLHTMAAMFPKLQQEWNIHLNVPVLTSVKPLKSKSSPILLQRVRSSHSTTKQPPPKHRDSVPLRIASQQGSQMEAIWKADVASSSHPIEKKIPTSLSWEQLGGHPDIPRLLAADEHTSYPRSSASFKPRSFSASSIQRKECQEPSEEPAELVRKVSCQSLPESLQSQKDRVAPVPTPNPSL", "length": 938 }, "evidence": [ { "id": "E1BBQ1", "url": "https://omabrowser.org/oma/group/E1BBQ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IYM0-1", "protein_name": "Protein FAM186B", "gene_name": "FAM186B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKDDPPQLVTPTSVKAIILRIEAAQLTRAQEDISTQLSDILDNVNCVINRFQEELGYDLKENAKSQQRDPKGKKRFILLEKIASFSKDAMMKEKHLYDILRWLGDWGDTLTYEIGPRKSEEEAAALDEWIEVTEKVLPLSLIATKRGIESLTALCSTLIEGQKKRSQVSKRTFWQGWQGRSPQTSPSHPQPLSPEQMLQDQHTMNTKASEVTSMLQELLDSTMFSKGEVRAIRYMATVVENLNKALILQHKENRSLETKYRHLQMQATKELSSQRLHFQQFMEVLESRRDALLKQVEILGGRYHDLLLMKQALEFQLKKAQNATGQAEDLAEVSVDSPGPSERETLPRKETVMEESQQEPMKEEQLFSPLPPSPMAMIRDSGAIAAGHQPLSTMTVRSRVADVFGSKDTESLEPVLLPLVDRRFPKKWERPVAESLGHKDKDQEDYFQKGGLQIKFHCSKQLSLESSRQVTSESQEEPWEEEFGREMRRQLWLEEEEMWQQRQKKWALLEQEHQEKLRQWNLEDLAREQQRRWVQLEKEQESPRREPEQLGEDVERRIFTPTSRWRDLEKAELSLVPAPSRTQSAHQSRRPHLPMSPSTQQPALGKQRPMSSVEFTYRPRTRRVPTKPKKSASFPVTGTSIRRLTWPSLQISPANIKKKVYHMDMEAQRKNLQLLSEESELRLPHYLRSKALELTTTTMELGALRLQYLCHKYIFYRRLQSLRQEAINHVQIMKETEASYKAQNLYIFLENIDRLQSLRLQAWTDKQKGLEEKHRECLSSMVTMFPKLQLEWNVHLNIPEVTSPKPKKCKLPAASPRHIRPSGPTYKQPFLSRHRACVPLQMARQQGKQMEAVWKTEVASSSYAIEKKTPASLPRDQLRGHPDIPRLLTLDV", "length": 893 }, "evidence": [ { "id": "E1BBQ1", "url": "https://omabrowser.org/oma/group/E1BBQ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 932, "end_pos": 934, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBQ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 956, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBQ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBQ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1" }, { "id": "PF20865", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM186A/B C-terminal", "eco_id": "ECO_0000259", "start_pos": 657, "end_pos": 892, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ1" }, { "id": "PF20870", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20870" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM186A/B N-terminal", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 255, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 932, "end_pos": 934 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCB3-1", "uniprot_ac": "E1BCB3", "uniprot_id": "E1BCB3_BOVIN", "mass": { "chemical_mass": 28309.0, "monoisotopic_mass": 28309.0 }, "refseq": {}, "gene_names": [ { "name": "EBPL", "type": "recommended", "evidence": [ { "id": "E1BCB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" } ] } ], "protein_names": [ { "name": "EBP like", "type": "synonym", "evidence": [ { "id": "E1BCB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCB3", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EBPL", "url": "https://www.uniprot.org/uniprotkb/E1BCB3", "locus": { "chromosome": "12", "start_pos": 19203457, "end_pos": 19234405, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018410", "url": "https://www.ensembl.org/id/ENSBTAG00000018410" } ] } } ], "crossref": [ { "id": "E1BCB3", "url": "https://alphafold.ebi.ac.uk/entry/E1BCB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018410", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018410", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007905", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007905", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCB3", "url": "https://www.orthodb.org/?gene=E1BCB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14207:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14207:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LU36", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCB3", "url": "https://www.uniprot.org/uniprotkb/E1BCB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCB3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHAGGELGAAAGGSLLLCASLLAVGCALGLRLGRGRGAADRGLLAWLCFNALVHFALEGPYVYLSMVGNITHSDALIASLCGSDGKESACNAGYLGSIPGSGRSPGEGHDNPLQYSCLEHSMDRGAWWATVTWKEYGKADARWLYFDPTIVSVEILTVVLGGSLALVLVYAIVKEKHYRHFVQITLCVCELYGGWMTFCPDWLMGSPNLNTNSWLYFWVYLVFFNGVWVLIPGLLLWQSWVELKKMHHKGSNSRKKFQ", "length": 258, "header": "tr|E1BCB3-1|E1BCB3_BOVIN Isoform 1 of EBP like OS=Bos taurus OX=9913 GN=EBPL PE=3 SV=2 CANONICAL=E1BCB3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU36/entry", "sequence": { "sequence": "VLRGAAGREAEAFFRPTPSPRSPASSPRSPASSPRRPVFPLPARGAIPVQVRTVCAGSRKHARGRGAGRRGGRLAAAVRLAAGGGLRAGPAPGPGSGGGGPRAARLALLQRPGAFRAGKEYGKADARWLYFDPTIVSVEILTVVLGGSLALVLVYAIVKEKHYRHFVQITLCVCELYGGWMTFCPDWLMGSPNLNTNSWLYFWVYLVFFNGVWVLIPGLLLWQSWVELKKMHHKGSNSRKKFQ", "length": 243, "header": "tr|A0A3Q1LU36-1|A0A3Q1LU36_BOVIN Computationally mapped isoform of EBP like OS=Bos taurus OX=9913 GN=EBPL PE=3 SV=2 CANONICAL=E1BCB3-1" }, "locus": { "chromosome": "12", "start_pos": 19233067, "end_pos": 19203878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067559.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067559.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064013.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064013.2" } ] } }, { "isoform_ac": "A0AAA9SBU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU0/entry", "sequence": { "sequence": "MSWLSCKESACQCRRQVPSLGQEDSSGEKRQPTPVEQRSLVGYSLWSGKDSDTTEQLNSNTEGPYVYLSMVGNITHSDALIASLWKEYGKADARWLYFDPTIVSVEILTVVLGGSLALVLVYAIVKEKHYRHFVQITLCVCELYGGWMTFCPDWLMGSPNLNTNSWLYFWVYLVFFNGVWVLIPGLLLWQSWVELKKMHHKGSNSRKKFQ", "length": 210, "header": "tr|A0AAA9SBU0-1|E1BCB3_BOVIN Computationally mapped isoform of EBP like OS=Bos taurus OX=9913 GN=EBPL PE=3 SV=1 CANONICAL=E1BCB3-1" }, "locus": { "chromosome": "12", "start_pos": 19234206, "end_pos": 19203878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098372.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098372.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080963.1" } ] } }, { "isoform_ac": "A0AAA9T6Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y3/entry", "sequence": { "sequence": "MHAGGELGAAAGGSLLLCASLLAVGCALGLRLGRGRGAADRGLLAWLCFNALVHFALEGPYVYLSMVGNITHSDALIASLCISYRSPCACVNCMAGG", "length": 97, "header": "tr|A0AAA9T6Y3-1|E1BCB3_BOVIN Computationally mapped isoform of EBP like OS=Bos taurus OX=9913 GN=EBPL PE=3 SV=1 CANONICAL=E1BCB3-1" }, "locus": { "chromosome": "12", "start_pos": 19232886, "end_pos": 19204066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114430.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114430.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094528.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094528.1" } ] } }, { "isoform_ac": "E1BCB3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCB3/entry", "sequence": { "sequence": "MHAGGELGAAAGGSLLLCASLLAVGCALGLRLGRGRGAADRGLLAWLCFNALVHFALEGPYVYLSMVGNITHSDALIASLCGSDGKESACNAGYLGSIPGSGRSPGEGHDNPLQYSCLEHSMDRGAWWATVTWKEYGKADARWLYFDPTIVSVEILTVVLGGSLALVLVYAIVKEKHYRHFVQITLCVCELYGGWMTFCPDWLMGSPNLNTNSWLYFWVYLVFFNGVWVLIPGLLLWQSWVELKKMHHKGSNSRKKFQ", "length": 258, "header": "tr|E1BCB3-1|E1BCB3_BOVIN Isoform 1 of EBP like OS=Bos taurus OX=9913 GN=EBPL PE=3 SV=2 CANONICAL=E1BCB3-1" }, "locus": { "chromosome": "12", "start_pos": 19232886, "end_pos": 19203878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024496.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024496.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024496.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024496.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BCB3", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BCB3", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sterol metabolic process", "id": "GO:0016125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016125", "evidence": [ { "database": "UniProtKB", "id": "E1BCB3", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cholestenol delta-isomerase activity", "id": "GO:0047750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047750", "evidence": [ { "database": "UniProtKB", "id": "E1BCB3", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCB3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCB3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCB3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB3" }, { "id": "PS51751", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51751" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EXPERA", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 236, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B882-1", "uniprot_ac": "E1B882", "uniprot_id": "E1B882_BOVIN", "mass": { "chemical_mass": 313740.0, "monoisotopic_mass": 313740.0 }, "refseq": { "ac": "XP_059739914", "name": "matrix-remodeling-associated protein 5 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739914" }, "gene_names": [ { "name": "MXRA5", "type": "recommended", "evidence": [ { "id": "E1B882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B882" } ] }, { "name": "MXRA5", "type": "synonym", "evidence": [ { "id": "XP_059739914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739914" } ] } ], "protein_names": [ { "name": "Matrix remodeling associated 5", "type": "synonym", "evidence": [ { "id": "E1B882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B882/entry#names_and_taxonomy" } ] }, { "name": "matrix-remodeling-associated protein 5 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059739914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739914" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B882", "url": "https://www.uniprot.org/uniprotkb/E1B882" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MXRA5", "url": "https://www.uniprot.org/uniprotkb/E1B882", "locus": { "chromosome": "X", "start_pos": 138541052, "end_pos": 138511660, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022150", "url": "https://www.ensembl.org/id/ENSBTAG00000022150" } ] } } ], "crossref": [ { "id": "ENSBTAG00000022150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786844", "url": "https://www.ncbi.nlm.nih.gov/gene/786844", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786844", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786844", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B882", "url": "https://www.orthodb.org/?gene=E1B882", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739914", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739914", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B882", "url": "https://www.uniprot.org/uniprotkb/E1B882", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B882-1", "url": "https://www.uniprot.org/uniprotkb/E1B882-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLWAHRSGGSRLPTNRCAGMAHPDEMPMTWARWRALSMVLILLWGRPHVALACPHPCACYVPSEVHCTFRSLASVPAGISPHVERINLGFNSIQALSETSFTGLTKLELLMIHGNDIPSIPDGALRDLISLQVFKFSYNKLRVITGETLQGLWNLVRLHMDHNQIEFIHPEAFRGLTSLRLLHLEGNLLRQLHPATFSTFAFLDYFRLSTVRHLYLAENAISTLPTGMLQNMPLLENLYLHGNPWACDCDMTWFLQWDAKTKGVLKCKKDKAYEGGQLCSTCFSPKKWHGQELQKLRDVRCQKPSIESPLRQNRSRSSEDDQDEDEGADHPFSPDGFQFPAWNVSVNMSDEHGNTVHLVCDIKKPTDVYRLHLNQTDPQEIEINATVALDFECPMTRQNYEKLWKLIAYYSEVPVKLHREPALGKDPRLGYQYRQDADDDSTLYYTGVRAHVLAEPEWVTQPSIELQLNRRLSSAKLVVLSYSSRHALVMSAKDARLSPSRSWVMIEPGRAVQRAQTVLEGSACQLSCNVRASESPSISWVLPDGSVVKAPMEDRDGRFSVLTSGWLKIRSTQPSDAGLYQCIARVRDETDRMLYRVLVQPPVIQPPDAYTVTIQKNPGEPVTLPCQALAVPEAQISWILPNKRMLNAMANASHAYVLADGTLSIPKVQGSDSGYYRCVAVNQRGSDHFTVGVQVSKKGSRGSPKRRGRPGGRTLSGGRGGIVEDEGGSGMGDEENTSKTVLHPQDQEALIRATDDASGGGKKTRKGRRKLKPWKHPTKEPETNVAEGRRVFESRRRVNVAKKQINPERWADILARVRGRSLPKGTEGPQVITVRAPSLMRQEVTSPLPAVAPGSVSPVQTTSSSEESSGDMFVFGEEEQASSAVSSPRTIPLQPGHDGVVHSEPRVTGTRSEEFIDEDSSEKTVGATPTEVDSNQTPATTLASVLYESSTLQTLEMEHKEPTEENVATDSWSTLHVGSVPEATSPEDESPMDAVPLAESETVTYFYPDLGTNSQPAEKTVKEQASTRFTPTPASWVAEARTSEPLEDPTLGDPSIPVETHLQEQTDSPQLVETGLSTPGHPLTPEGMKETSQTLQEEGTLETHPTDSRSIKGNGQAVHLTTPLDSTLEVVNSVTDFQHPRESMPGVVFGKDMTTAPVTTPAQKDTSPSALTTHPSRKRPNGRRRFRPHKFRHRHKQTPHTTFAPTDAFSPPPTQVPEAKTPSLQVASSLVPTTWVNSAVGTAGRLDTEEHAESVSRGSPHRKQGKKRNRHRYITSTLSSAASVSKPSFSPEDKHRISFPLSSQAALSPTTVSFTTGDPREITGMGAYSTASISKTYSASDRFQETVPVTREPASDGQETKNHGVTDLRDYQTHGLVPGDSVTHAASPSVAEVSPARGFKEVSLTSPFPKTTSWDPPGATQLGVEHTDPPVTSPSEALTESPSVRESADLGEFSPSAAVSTLFQPQRAAPSTTLPVLKVEASSSLAETTVRDQGGRETTHTTVRSEIGPQSRVSTPTPLEEPESPFPPTTLMSSTETTAEPTPPLPSGTSPAWKASKHHVTFHYVGTPETKAPSVNNEVTQHLSKAHQLSTPSSKQDRFTLTPEEALRKEAFDGTMKNMLPHVPDSPDEAGRVPVFHQPARVPATPIPPRGTMRPPHTVTQSPFRYSVTFQPPRHLTRKPGVTAYPSRVWPEGRHATTPRSPSYPTTPVVVLWPGSKPSVPGTVTGQGADRFQGNSRSFANNHLPDLRRDPVGKLPNSRAPPLPGGRFPFFINRTLSFPQLGGTPKPQGPSSPAPALRDRKVNVGPHTRIHSQSIFHMDLGPPAPPILHPPRTTAPPSMNVQTIPPGSSTRSSVPFTTSSVPPSRSFHHGSTKLFSAGGLPASKFWTLGEKPQIVTKSPQSVTVTVETDVTFPCEATGKPKPFVTWTKLSTGALMTPNTRLQRFEVLKNGTFVIRSVQVQDRGQYVCTAKNLHGADRMVVLLAVTAQQPQILASHYKDVTVYLGDTIAMECLAKGTPVPQISWVFPDGRVWQTVSPVEGRVTLHENRTLSIKEASFQDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKAENISLPPGLSIHIHCTARAAPLPSVRWVLRDGTQIRPSQFVHGNLFVFPNGTLYIRNLAPQDSGRYECVAANLVGSARRTVQLTVQRAAANARITGTSPQRTDVRYGGTLRLDCSASGDPWPRIVWRLPSKRMIDALFSFDTRIKAFANGTLVVKSVTDKDAGDYLCVARNKVGDDFVALKVNVVMKAAKIQHKEANDHRVLYGGDLKVDCLATGLPNPEISWSLPDGSLVNSFMQADDSGGRAKRYVVFHNGTLYFNEVGPREEGDYTCFAENQVGKDEMRVRVKVVSEPAAIRNKTYSVIHVPYGDVVTVACEAQGEPTPRVTWLSPTHRLIPASSDKYQVYQDGTLLIQKAQRSDSGNYTCVVRNSAGEDRKTVWIHVHVQPPTINGYPEAITTVREVAPGGSRKLIDCRAEGVPAPRVLWAFPEGVVLPAPYYGNRITIHRNGTLDIKSLRMSDSVQLACIGRNEGGEARLVVQLTVLEPLEKPVFHDPVSEKITAMAGHTISLNCSAAGTPTPTLLWVLPNGTELRSGQRLHRFFHKGDGRLHISGLSSEDAGAYRCVASNSAGHTERLVSLKVGLKPETNKRYNNLVSIVNGETLRLPCVPPGARGMRLSWTLPSGVVLDGPQVRGRFALWENGTLTVRDASVFDRGTYVCNADGEHGPSVVSIPVIVIAYPPRITSEPTPVIYARPGSIVKMNCMAMGIPKAEISWELPDKSHLTAGTQPRVYGNRFLHPQGSLTVQQATQRDAGFYKCTAKNLLGSDSKTTYVHIY", "length": 2867, "header": "tr|E1B882-1|E1B882_BOVIN Isoform 1 of Matrix remodeling associated 5 OS=Bos taurus OX=9913 GN=MXRA5 PE=4 SV=3 CANONICAL=E1B882-1" }, "isoforms": [ { "isoform_ac": "E1B882-1", "url": "https://www.uniprot.org/uniprotkb/E1B882/entry", "sequence": { "sequence": "MLWAHRSGGSRLPTNRCAGMAHPDEMPMTWARWRALSMVLILLWGRPHVALACPHPCACYVPSEVHCTFRSLASVPAGISPHVERINLGFNSIQALSETSFTGLTKLELLMIHGNDIPSIPDGALRDLISLQVFKFSYNKLRVITGETLQGLWNLVRLHMDHNQIEFIHPEAFRGLTSLRLLHLEGNLLRQLHPATFSTFAFLDYFRLSTVRHLYLAENAISTLPTGMLQNMPLLENLYLHGNPWACDCDMTWFLQWDAKTKGVLKCKKDKAYEGGQLCSTCFSPKKWHGQELQKLRDVRCQKPSIESPLRQNRSRSSEDDQDEDEGADHPFSPDGFQFPAWNVSVNMSDEHGNTVHLVCDIKKPTDVYRLHLNQTDPQEIEINATVALDFECPMTRQNYEKLWKLIAYYSEVPVKLHREPALGKDPRLGYQYRQDADDDSTLYYTGVRAHVLAEPEWVTQPSIELQLNRRLSSAKLVVLSYSSRHALVMSAKDARLSPSRSWVMIEPGRAVQRAQTVLEGSACQLSCNVRASESPSISWVLPDGSVVKAPMEDRDGRFSVLTSGWLKIRSTQPSDAGLYQCIARVRDETDRMLYRVLVQPPVIQPPDAYTVTIQKNPGEPVTLPCQALAVPEAQISWILPNKRMLNAMANASHAYVLADGTLSIPKVQGSDSGYYRCVAVNQRGSDHFTVGVQVSKKGSRGSPKRRGRPGGRTLSGGRGGIVEDEGGSGMGDEENTSKTVLHPQDQEALIRATDDASGGGKKTRKGRRKLKPWKHPTKEPETNVAEGRRVFESRRRVNVAKKQINPERWADILARVRGRSLPKGTEGPQVITVRAPSLMRQEVTSPLPAVAPGSVSPVQTTSSSEESSGDMFVFGEEEQASSAVSSPRTIPLQPGHDGVVHSEPRVTGTRSEEFIDEDSSEKTVGATPTEVDSNQTPATTLASVLYESSTLQTLEMEHKEPTEENVATDSWSTLHVGSVPEATSPEDESPMDAVPLAESETVTYFYPDLGTNSQPAEKTVKEQASTRFTPTPASWVAEARTSEPLEDPTLGDPSIPVETHLQEQTDSPQLVETGLSTPGHPLTPEGMKETSQTLQEEGTLETHPTDSRSIKGNGQAVHLTTPLDSTLEVVNSVTDFQHPRESMPGVVFGKDMTTAPVTTPAQKDTSPSALTTHPSRKRPNGRRRFRPHKFRHRHKQTPHTTFAPTDAFSPPPTQVPEAKTPSLQVASSLVPTTWVNSAVGTAGRLDTEEHAESVSRGSPHRKQGKKRNRHRYITSTLSSAASVSKPSFSPEDKHRISFPLSSQAALSPTTVSFTTGDPREITGMGAYSTASISKTYSASDRFQETVPVTREPASDGQETKNHGVTDLRDYQTHGLVPGDSVTHAASPSVAEVSPARGFKEVSLTSPFPKTTSWDPPGATQLGVEHTDPPVTSPSEALTESPSVRESADLGEFSPSAAVSTLFQPQRAAPSTTLPVLKVEASSSLAETTVRDQGGRETTHTTVRSEIGPQSRVSTPTPLEEPESPFPPTTLMSSTETTAEPTPPLPSGTSPAWKASKHHVTFHYVGTPETKAPSVNNEVTQHLSKAHQLSTPSSKQDRFTLTPEEALRKEAFDGTMKNMLPHVPDSPDEAGRVPVFHQPARVPATPIPPRGTMRPPHTVTQSPFRYSVTFQPPRHLTRKPGVTAYPSRVWPEGRHATTPRSPSYPTTPVVVLWPGSKPSVPGTVTGQGADRFQGNSRSFANNHLPDLRRDPVGKLPNSRAPPLPGGRFPFFINRTLSFPQLGGTPKPQGPSSPAPALRDRKVNVGPHTRIHSQSIFHMDLGPPAPPILHPPRTTAPPSMNVQTIPPGSSTRSSVPFTTSSVPPSRSFHHGSTKLFSAGGLPASKFWTLGEKPQIVTKSPQSVTVTVETDVTFPCEATGKPKPFVTWTKLSTGALMTPNTRLQRFEVLKNGTFVIRSVQVQDRGQYVCTAKNLHGADRMVVLLAVTAQQPQILASHYKDVTVYLGDTIAMECLAKGTPVPQISWVFPDGRVWQTVSPVEGRVTLHENRTLSIKEASFQDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKAENISLPPGLSIHIHCTARAAPLPSVRWVLRDGTQIRPSQFVHGNLFVFPNGTLYIRNLAPQDSGRYECVAANLVGSARRTVQLTVQRAAANARITGTSPQRTDVRYGGTLRLDCSASGDPWPRIVWRLPSKRMIDALFSFDTRIKAFANGTLVVKSVTDKDAGDYLCVARNKVGDDFVALKVNVVMKAAKIQHKEANDHRVLYGGDLKVDCLATGLPNPEISWSLPDGSLVNSFMQADDSGGRAKRYVVFHNGTLYFNEVGPREEGDYTCFAENQVGKDEMRVRVKVVSEPAAIRNKTYSVIHVPYGDVVTVACEAQGEPTPRVTWLSPTHRLIPASSDKYQVYQDGTLLIQKAQRSDSGNYTCVVRNSAGEDRKTVWIHVHVQPPTINGYPEAITTVREVAPGGSRKLIDCRAEGVPAPRVLWAFPEGVVLPAPYYGNRITIHRNGTLDIKSLRMSDSVQLACIGRNEGGEARLVVQLTVLEPLEKPVFHDPVSEKITAMAGHTISLNCSAAGTPTPTLLWVLPNGTELRSGQRLHRFFHKGDGRLHISGLSSEDAGAYRCVASNSAGHTERLVSLKVGLKPETNKRYNNLVSIVNGETLRLPCVPPGARGMRLSWTLPSGVVLDGPQVRGRFALWENGTLTVRDASVFDRGTYVCNADGEHGPSVVSIPVIVIAYPPRITSEPTPVIYARPGSIVKMNCMAMGIPKAEISWELPDKSHLTAGTQPRVYGNRFLHPQGSLTVQQATQRDAGFYKCTAKNLLGSDSKTTYVHIY", "length": 2867, "header": "tr|E1B882-1|E1B882_BOVIN Isoform 1 of Matrix remodeling associated 5 OS=Bos taurus OX=9913 GN=MXRA5 PE=4 SV=3 CANONICAL=E1B882-1" }, "locus": { "chromosome": "X", "start_pos": 138540048, "end_pos": 138512185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029882.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029882.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029877.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029877.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1032, "start_aa": "Thr", "end_pos": 1032, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1032", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1542, "start_aa": "Thr", "end_pos": 1542, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1542", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2610, "start_aa": "Thr", "end_pos": 2610, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2610", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:786844", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786844", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to transforming growth factor beta", "id": "GO:0071559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071559", "evidence": [ { "database": "UniProtKB", "id": "E1B882", "url": "https://www.uniprot.org/uniprotkb/E1B882" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1B882", "url": "https://www.uniprot.org/uniprotkb/E1B882" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1773, "end_pos": 1775, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1949, "end_pos": 1951, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2046, "end_pos": 2048, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2095, "end_pos": 2097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2143, "end_pos": 2145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2242, "end_pos": 2244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2345, "end_pos": 2347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2389, "end_pos": 2391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2454, "end_pos": 2456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2539, "end_pos": 2541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2602, "end_pos": 2604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2619, "end_pos": 2621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2732, "end_pos": 2734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 651, "end_pos": 653, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 935, "end_pos": 937, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B882" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 499, "end_pos": 584, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1032, 1542, 2610 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1773, "end_pos": 1775 }, { "start_pos": 1949, "end_pos": 1951 }, { "start_pos": 2046, "end_pos": 2048 }, { "start_pos": 2095, "end_pos": 2097 }, { "start_pos": 2143, "end_pos": 2145 }, { "start_pos": 2242, "end_pos": 2244 }, { "start_pos": 2345, "end_pos": 2347 }, { "start_pos": 2389, "end_pos": 2391 }, { "start_pos": 2454, "end_pos": 2456 }, { "start_pos": 2539, "end_pos": 2541 }, { "start_pos": 2602, "end_pos": 2604 }, { "start_pos": 2619, "end_pos": 2621 }, { "start_pos": 2732, "end_pos": 2734 }, { "start_pos": 313, "end_pos": 315 }, { "start_pos": 343, "end_pos": 345 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 651, "end_pos": 653 }, { "start_pos": 736, "end_pos": 738 }, { "start_pos": 935, "end_pos": 937 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B960-1", "uniprot_ac": "E1B960", "uniprot_id": "E1B960_BOVIN", "mass": { "chemical_mass": 71882.0, "monoisotopic_mass": 71882.0 }, "refseq": {}, "gene_names": [ { "name": "CDH3", "type": "recommended", "evidence": [ { "id": "E1B960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ] }, { "name": "ZFP90", "type": "recommended", "evidence": [ { "id": "E1B960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ] }, { "name": "ZFP90", "type": "synonym", "evidence": [ { "id": "E1B960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ] } ], "protein_names": [ { "name": "Zinc finger protein 90", "type": "recommended", "evidence": [ { "id": "E1B960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B960/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cadherins are calcium-dependent cell adhesion proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG24#function" }, { "database": "UniProtKB", "id": "RU004357", "url": "https://www.uniprot.org/uniprotkb/RU004357#function" }, { "database": "UniProtKB", "id": "A0AAA9T300", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T300#function" }, { "database": "UniProtKB", "id": "A0AAA9T6Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Z9#function" }, { "database": "UniProtKB", "id": "A0AAA9TSI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI3#function" }, { "database": "UniProtKB", "id": "E1BGT1", "url": "https://www.uniprot.org/uniprotkb/E1BGT1#function" } ] }, { "annotation": "Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960#function" }, { "database": "UniProtKB", "id": "ARBA00056474", "url": "https://www.uniprot.org/uniprotkb/ARBA00056474#function" }, { "database": "UniProtKB", "id": "A0AAA9SES3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES3#function" }, { "database": "UniProtKB", "id": "A0AAA9SDY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY3#function" }, { "database": "UniProtKB", "id": "A0ABI0P7F0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7F0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFP90", "url": "https://www.uniprot.org/uniprotkb/E1B960", "locus": { "chromosome": "18", "start_pos": 35904830, "end_pos": 35875679, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007488", "url": "https://www.ensembl.org/id/ENSBTAG00000007488" } ] } } ], "crossref": [ { "id": "E1B960", "url": "https://alphafold.ebi.ac.uk/entry/E1B960", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007488", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007488", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000033248", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033248", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100139934", "url": "https://www.ncbi.nlm.nih.gov/gene/100139934", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "281063", "url": "https://www.ncbi.nlm.nih.gov/gene/281063", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281063", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281063", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EPVCTYT", "url": "https://omabrowser.org/oma/group/EPVCTYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BGT1", "url": "https://www.orthodb.org/?gene=E1BGT1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027:SF446", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027:SF446", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SES3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SES3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T300", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T300", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T300-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T300-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7F0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7F0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B960-1", "url": "https://www.uniprot.org/uniprotkb/E1B960-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGT1", "url": "https://www.uniprot.org/uniprotkb/E1BGT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGT1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGT1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSKMESLTFKDVAVNFTQEEWHHVDAAQRRLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWIAEGEIQRPVCPDWKTRPEAKSSHLQQSISKVSLSTDELSHTTGEDAWDLSGQLERHKENWKRHLGPDSSTQKKIITPEETCEQNTFGENCRLNTDLITQLNIPPGSSECDTLGSNLGHNSDLLNQNNILAKKKPYKCNKCRKAFIHRSSLTKHEKTHKGDGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSNNYSIDFKHSSSLTQDESNVPEVKSYHCNACGEDFSHIADFSDHQRIHTGDKNPYDCEQAFSQQPISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECKECGRAFRKKTNLHDHQRIHTGEKPYACKECGKNFSRSSALTKHMRIHTRNKL", "length": 629, "header": "tr|E1B960-1|E1B960_BOVIN Isoform 1 of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=4 CANONICAL=E1B960-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY3/entry", "sequence": { "sequence": "MLSKMTLSLGALPGDPGMAPRPPTARHQESLTFKDVAVNFTQEEWHHVDAAQRRLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWIAEGEIQRPVCPDWKTRPEAKSSHLQQSISKVSLSTDELSHTTGEDAWDLSGQLERHKENWKRHLGPDSSTQKKIITPEETCEQNTFGENCRLNTDLITQLNIPPGSSECDTLGSNLGHNSDLLNQNNILAKKKPYKCNKCRKAFIHRSSLTKHEKTHKGDGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSNNYSIDFKHSSSLTQDESNVPEVKSYHCNACGEDFSHIADFSDHQRIHTGDKNPYDCEQAFSQQPISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECKECGRAFRKKTNLHDHQRIHTGEKPYACKECGKNFSRSSALTKHMRIHTRNKL", "length": 652, "header": "tr|A0AAA9SDY3-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=1 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 35903826, "end_pos": 35875760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112671.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112671.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084344.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084344.1" } ] } }, { "isoform_ac": "A0AAA9SES3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES3/entry", "sequence": { "sequence": "MGPRPRSPEPQQATLSLGALPGDPGMAPRPPTARHQESLTFKDVAVNFTQEEWHHVDAAQRRLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWIAEGEIQRPVCPDWKTRPEAKSSHLQQSISKVSLSTDELSHTTGEDAWDLSGQLERHKENWKRHLGPDSSTQKKIITPEETCEQNTFGENCRLNTDLITQLNIPPGSSECDTLGSNLGHNSDLLNQNNILAKKKPYKCNKCRKAFIHRSSLTKHEKTHKGDGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSNNYSIDFKHSSSLTQDESNVPEVKSYHCNACGEDFSHIADFSDHQRIHTGDKNPYDCEQAFSQQPISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECKECGRAFRKKTNLHDHQRIHTGEKPYACKECGKNFSRSSALTKHMRIHTRNKL", "length": 660, "header": "tr|A0AAA9SES3-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=1 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 35903826, "end_pos": 35882981, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128955.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128955.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082342.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082342.1" } ] } }, { "isoform_ac": "A0AAA9SG24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG24/entry", "sequence": { "sequence": "MRVRPLWASLPSCQLTTATKSVQAQVYWLPRAASEPCRAGFGEAEVTLEARGAELEPGQALGKVVFTDCPGQESALLTDDDFIVLNDETVQERKALKISPPAPVLRRRKREWVVPPISVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGIFAIEKETGWLLLNKPLDREKIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDVFRGSVLEGVLPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKDPNDLMFTVHRSTGTISVISSGLDRERVPEYTLTIHATDMDGDGSSTTAMAIVEILDANDNAPVFDPQKYEARVPENTVSHEVQRLTVTDLDAPNSPAWRATYRIVGGDNGDHFTITTDPESNQGILTTQKGLDFEAKTQHTLYVEVINEVPFVVKLPTSTATVVVLVEDVNEPPVFVPPSKVIEIQEGISTGEPICAYTARDPDKGSQKISYHILRDPAGWLAMDPDSGQVTAAGVLDREDEQFVRNNIYEVMVLATDDGSPPTTGTGTLLLTLMDINDHGPVPEPRQITICNQSPVPQVLNITDKDLSPHTAPFQAQLTHDSDVYWTAEVNEKGDAVALSLKKFLKQGEYDVHLSLSDHGNKEQLTVIRATVCDCHGNMVTCRDPWTWGFLLPILGAALALLLLLLVLLFLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPSFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLNEWGSRFKKLADMYGGGQDD", "length": 832, "header": "tr|A0AAA9SG24-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=1 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 36014872, "end_pos": 35953555, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125746.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125746.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081419.1" } ] } }, { "isoform_ac": "A0AAA9T300-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T300/entry", "sequence": { "sequence": "MGLRGGPLASLLLRFFLLLQAQVYWLPRAASEPCRAGFGEAEVTLEARGAELEPGQALGKVVFTDCPGQESALLTDDDFIVLNDETVQERKALKISPPAPVLRRRKREWVVPPISVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGIFAIEKETGWLLLNKPLDREKIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDVFRGSVLEGVLPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKDPNDLMFTVHRSTGTISVISSGLDRERVPEYTLTIHATDMDGDGSSTTAMAIVEILDANDNAPVFDPQKGLDFEAKTQHTLYVEVINEVPFVVKLPTSTATVVVLVEDVNEPPVFVPPSKVIEIQEGISTGEPICAYTARDPDKGSQKISYHILRDPAGWLAMDPDSGQVTAAGVLDREDEQFVRNNIYEVMVLATDDGSPPTTGTGTLLLTLMDINDHGPVPEPRQITICNQSPVPQVLNITDKDLSPHTAPFQAQLTHDSDVYWTAEVNEKGDAVALSLKKFLKQGEYDVHLSLSDHGNKEQLTVIRATVCDCHGNMVTCRDPWTWGFLLPILGAALALLLLLLVLLFLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPSFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLNEWGSRFKKLADMYGGGQDD", "length": 767, "header": "tr|A0AAA9T300-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=1 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 36014872, "end_pos": 35970301, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109040.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109040.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090865.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090865.1" } ] } }, { "isoform_ac": "A0AAA9T6Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Z9/entry", "sequence": { "sequence": "MDSRGRNPKTCLSRTWLRLKSDASKEEGLTAKLITSRGSRLPCCEDAQAALWSGLRRTEASCQQFQLASHAQVYWLPRAASEPCRAGFGEAEVTLEARGAELEPGQALGKVVFTDCPGQESALLTDDDFIVLNDETVQERKALKISPPAPVLRRRKREWVVPPISVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGIFAIEKETGWLLLNKPLDREKIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDVFRGSVLEGVLPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKDPNDLMFTVHRSTGTISVISSGLDRERVPEYTLTIHATDMDGDGSSTTAMAIVEILDANDNAPVFDPQKYEARVPENTVSHEVQRLTVTDLDAPNSPAWRATYRIVGGDNGDHFTITTDPESNQGILTTQKGLDFEAKTQHTLYVEVINEVPFVVKLPTSTATVVVLVEDVNEPPVFVPPSKVIEIQEGISTGEPICAYTARDPDKGSQKISYHILRDPAGWLAMDPDSGQVTAAGVLDREDEQFVRNNIYEVMVLATDDGSPPTTGTGTLLLTLMDINDHGPVPEPRQITICNQSPVPQVLNITDKDLSPHTAPFQAQLTHDSDVYWTAEVNEKGDAVALSLKKFLKQGEYDVHLSLSDHGNKEQLTVIRATVCDCHGNMVTCRDPWTWGFLLPILGAALALLLLLLVLLFLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPSFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLNEWGSRFKKLADMYGGGQDD", "length": 879, "header": "tr|A0AAA9T6Z9-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=2 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 36014872, "end_pos": 35898300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132052.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132052.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093667.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093667.2" } ] } }, { "isoform_ac": "A0AAA9TSI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSI3/entry", "sequence": { "sequence": "MNAAPLFPAGFRCISTSFSHSSRKAQRPFSSRAAKAEEGAQVYWLPRAASEPCRAGFGEAEVTLEARGAELEPGQALGKVVFTDCPGQESALLTDDDFIVLNDETVQERKALKISPPAPVLRRRKREWVVPPISVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGIFAIEKETGWLLLNKPLDREKIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDVFRGSVLEGVLPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKDPNDLMFTVHRSTGTISVISSGLDRERVPEYTLTIHATDMDGDGSSTTAMAIVEILDANDNAPVFDPQKYEARVPENTVSHEVQRLTVTDLDAPNSPAWRATYRIVGGDNGDHFTITTDPESNQGILTTQKGLDFEAKTQHTLYVEVINEVPFVVKLPTSTATVVVLVEDVNEPPVFVPPSKVIEIQEGISTGEPICAYTARDPDKGSQKISYHILRDPAGWLAMDPDSGQVTAAGVLDREDEQFVRNNIYEVMVLATDDGSPPTTGTGTLLLTLMDINDHGPVPEPRQITICNQSPVPQVLNITDKDLSPHTAPFQAQLTHDSDVYWTAEVNEKGDAVALSLKKFLKQGEYDVHLSLSDHGNKEQLTVIRATVCDCHGNMVTCRDPWTWGFLLPILGAALALLLLLLVLLFLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPSFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLNEWGSRFKKLADMYGGGQDD", "length": 848, "header": "tr|A0AAA9TSI3-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=1 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 36014872, "end_pos": 35969733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113287.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113287.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101566.1" } ] } }, { "isoform_ac": "A0ABI0P7F0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7F0/entry", "sequence": { "sequence": "MWSDRNGQPQESLTFKDVAVNFTQEEWHHVDAAQRRLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWIAEGEIQRPVCPDWKTRPEAKSSHLQQSISKVSLSTDELSHTTGEDAWDLSGQLERHKENWKRHLGPDSSTQKKIITPEETCEQNTFGENCRLNTDLITQLNIPPGSSECDTLGSNLGHNSDLLNQNNILAKKKPYKCNKCRKAFIHRSSLTKHEKTHKGDGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSNNYSIDFKHSSSLTQDESNVPEVKSYHCNACGEDFSHIADFSDHQRIHTGDKNPYDCEQAFSQQPISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECKECGRAFRKKTNLHDHQRIHTGEKPYACKECGKNFSRSSALTKHMRIHTRNKL", "length": 634, "header": "tr|A0ABI0P7F0-1|A0ABI0P7F0_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=1 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 35903826, "end_pos": 35814747, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150900.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150900.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107749.1" } ] } }, { "isoform_ac": "E1B960-1", "url": "https://www.uniprot.org/uniprotkb/E1B960/entry", "sequence": { "sequence": "MLSKMESLTFKDVAVNFTQEEWHHVDAAQRRLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWIAEGEIQRPVCPDWKTRPEAKSSHLQQSISKVSLSTDELSHTTGEDAWDLSGQLERHKENWKRHLGPDSSTQKKIITPEETCEQNTFGENCRLNTDLITQLNIPPGSSECDTLGSNLGHNSDLLNQNNILAKKKPYKCNKCRKAFIHRSSLTKHEKTHKGDGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSNNYSIDFKHSSSLTQDESNVPEVKSYHCNACGEDFSHIADFSDHQRIHTGDKNPYDCEQAFSQQPISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECKECGRAFRKKTNLHDHQRIHTGEKPYACKECGKNFSRSSALTKHMRIHTRNKL", "length": 629, "header": "tr|E1B960-1|E1B960_BOVIN Isoform 1 of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=4 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 35903826, "end_pos": 35875760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032517.7", "url": "https://www.ensembl.org/id/ENSBTAT00000032517.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032448.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032448.6" } ] } }, { "isoform_ac": "E1BGT1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGT1/entry", "sequence": { "sequence": "MGLRGGPLASLLLRFFLLLQAQVYWLPRAASEPCRAGFGEAEVTLEARGAELEPGQALGKVVFTDCPGQESALLTDDDFIVLNDETVQERKALKISPPAPVLRRRKREWVVPPISVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGIFAIEKETGWLLLNKPLDREKIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDVFRGSVLEGVLPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKDPNDLMFTVHRSTGTISVISSGLDRERVPEYTLTIHATDMDGDGSSTTAMAIVEILDANDNAPVFDPQKYEARVPENTVSHEVQRLTVTDLDAPNSPAWRATYRIVGGDNGDHFTITTDPESNQGILTTQKGLDFEAKTQHTLYVEVINEVPFVVKLPTSTATVVVLVEDVNEPPVFVPPSKVIEIQEGISTGEPICAYTARDPDKGSQKISYHILRDPAGWLAMDPDSGQVTAAGVLDREDEQFVRNNIYEVMVLATDDGSPPTTGTGTLLLTLMDINDHGPVPEPRQITICNQSPVPQVLNITDKDLSPHTAPFQAQLTHDSDVYWTAEVNEKGDAVALSLKKFLKQGEYDVHLSLSDHGNKEQLTVIRATVCDCHGNMVTCRDPWTWGFLLPILGAALALLLLLLVLLFLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPSFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLNEWGSRFKKLADMYGGGQDD", "length": 829, "header": "tr|E1BGT1-1|E1B960_BOVIN Computationally mapped isoform of Zinc finger protein 90 OS=Bos taurus OX=9913 GN=ZFP90 PE=3 SV=3 CANONICAL=E1B960-1" }, "locus": { "chromosome": "18", "start_pos": 36014872, "end_pos": 35970301, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045591.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045591.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042970.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042970.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281063", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281063", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-418990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "resource": "Reactome", "description": "Adherens junctions interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LL01-1", "protein_name": "Cadherin 3", "gene_name": "Cdh3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHRGTLWCNYILGIVCLEGRMLGSHLHQVCWLRSVVSESYREDFIREAGVTLEVGGTDLEPSQALEKEALAGHEVLGADSGGIITLNRETVQGGKGVMNSPPSRILRRRKREWVMPPISVPENGKGPFPQRLNQLKSNKDRGTKLFYSITGPGADSPPEGVFTIEKETGWLLLNMPLDREKIVKYELFGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVPEGVMPGTSVMQVTATDEDDAINTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAEAVVQILDTNDNAPEFQPQKYEAWVPENAVGHEVQRLTVTDLDSPNSPAWRATYHIVGGDDGDHFTVATHPETNQGILTTKKGLDFEAQNQHTLYIEVTNEASFAVKLPTATATVVVHVEDVNEAPVFVPPSKVIEAQEGISIGELVCVYTAQDPDKEEQKISYSILRDPASWLAVDPDSGQITAAGILDREDEQFVKNDIYEVMVLATDNGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTMIRATVCDCHGQVLNDCPRPWKGGFILPVLGAVLALLTLLLALLLLVRKKRKVKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYNYLTEWGSRFKKLADMYGGGEDD", "length": 834 }, "evidence": [ { "id": "E1B960", "url": "https://omabrowser.org/oma/group/E1B960/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P10287-1", "protein_name": "Cadherin-3", "gene_name": "Cdh3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLSGPHAFLLLLLQVCWLRSVVSEPYRAGFIGEAGVTLEVEGTDLEPSQVLGKVALAGQGMHHADNGDIIMLTRGTVQGGKDAMHSPPTRILRRRKREWVMPPIFVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGVFTIEKESGWLLLHMPLDREKIVKYELYGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVLEGVMPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISSGLDREKVPEYRLTVQATDMDGEGSTTTAEAVVQILDANDNAPEFEPQKYEAWVPENEVGHEVQRLTVTDLDVPNSPAWRATYHIVGGDDGDHFTITTHPETNQGVLTTKKGLDFEAQDQHTLYVEVTNEAPFAVKLPTATATVVVHVKDVNEAPVFVPPSKVIEAQEGISIGELVCIYTAQDPDKEDQKISYTISRDPANWLAVDPDSGQITAAGILDREDEQFVKNNVYEVMVLATDSGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSPNSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTMIRATVCDCHGQVFNDCPRPWKGGFILPILGAVLALLTLLLALLLLVRKKRKVKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVVPTFIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQDYNYLNEWGSRFKKLADMYGGGEDD", "length": 822 }, "evidence": [ { "id": "E1B960", "url": "https://omabrowser.org/oma/group/E1B960/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P22223-1", "protein_name": "Cadherin-3", "gene_name": "CDH3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD", "length": 829 }, "evidence": [ { "id": "E1B960", "url": "https://omabrowser.org/oma/group/E1B960/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "catenin complex", "id": "GO:0016342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016342", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "hair follicle maturation", "id": "GO:0048820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048820", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "retina homeostasis", "id": "GO:0001895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001895", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "positive regulation of melanin biosynthetic process", "id": "GO:0048023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048023", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "positive regulation of keratinocyte proliferation", "id": "GO:0010838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010838", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "negative regulation of timing of catagen", "id": "GO:0051796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051796", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "cell-cell junction assembly", "id": "GO:0007043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007043", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "adherens junction organization", "id": "GO:0034332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034332", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "cell-cell adhesion mediated by cadherin", "id": "GO:0044331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044331", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1B960", "url": "https://www.uniprot.org/uniprotkb/E1B960" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 610, "end_pos": 612, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B960-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 629, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B960-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B960" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B960" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 230, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B960" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 79, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 610, "end_pos": 612 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9V5-1", "uniprot_ac": "E1B9V5", "uniprot_id": "E1B9V5_BOVIN", "mass": { "chemical_mass": 118643.0, "monoisotopic_mass": 118643.0 }, "refseq": {}, "gene_names": [ { "name": "CATSPERB", "type": "recommended", "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" } ] } ], "protein_names": [ { "name": "Cation channel sperm associated auxiliary subunit beta", "type": "synonym", "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9V5", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CATSPERB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5", "locus": { "chromosome": "21", "start_pos": 56298198, "end_pos": 56413423, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018709", "url": "https://www.ensembl.org/id/ENSBTAG00000018709" } ] } } ], "crossref": [ { "id": "E1B9V5", "url": "https://alphafold.ebi.ac.uk/entry/E1B9V5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018709", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018709", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14705", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14705", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14705:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14705:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15149", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15149", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21548", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22830", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22830", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1300642", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300642", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SEX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9V5", "url": "https://www.uniprot.org/uniprotkb/E1B9V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9V5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9V5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FQSEVEFTTKEFLSVFTSAGLAPSLEIINSTYTGVFHFNLTLYSDRVYWLIDIPRENITKNTDIAAVEEWLVRITLQYGLNIYTTEGTLLDTVREPILHWKLGTMMKKRTIQRLYPHVVDLKTTKCPCANDVALLGFVMNTTFDGVYIGLSFSGFWDYDDTQWYNLTDMVYSQVGEEHKQLSVVDMVLTNHFLVILTSLGLFISGDLRYPSSSVLMLSRVDFCGFERVDYIKGKLWYNERCFANRELFEVDYVTITFDRNRTLSEANSCFYSKEPFLEWLPCLPPVPKGTKTILSTVITFLVDQEQSSAVYLFHNQKNTIVSVRILKHNKPDLIQKFPPFSFPSSFSSPVGMIFHPRSHFLYAYGNQVWLSIDGGNTFDLIADFHDDIIKNTYHSFYTSDITLVSQSGKVYLTKAGLGKYSKIGSISDKVFTLYYDHMGFIHKLTPDHFEAGGSLAAFGNSKGIFGQAFDMGFDTALAPQYLTLNEMIFYAYVPKNEPKDRVHTKQFYDIHFGKLIHSRKTGTAYIRKVFQHNTPEGFLSSVIAELIDPFGIEEVNESSCLSSSLSISEAGNHSYKLSLQLQSKYNDISDEKTVVIPGYSSFLITTILDNENALAVATMPEIVPHNMTFQKDSWFLYNFGKRNGQTWNIYAKPCNYWFQQHDDSLSLSVLKYIDLGKSHTLKMKVIPNTKRKTLEIPLLQVIVGNPNLLEVKVEGYFDETDITLISLHLFGYFQGSTSLEFIVWGASTECYVTTFVPMLKSSCSYLKSMHHIPSETIPLEDWMSGVYVNSQGFNMIKVLPINYRPPSNMGIAIPLTDHFYHADPSKPIPRNLFYKSKRSGKFKQCANATTRKECNCTNDQKFSYAVAFSDCREKVPRFKFPVIQYPVSLQVYSEDGNFPVETPYLVTVTEVNNRENWNLRHTVPENVKKMKAYLESILSVPVYNPLGLNLSIKGSELFHFRVSVVPGVSFCNLVEEFQIYVDEVPLPFPGHTLIAVAAAVLLGGLIFIAFMFQIRNIHPWDTFKKLIRRNNVNPTNITAN", "length": 1040, "header": "tr|E1B9V5-1|E1B9V5_BOVIN Isoform 1 of Cation channel sperm associated auxiliary subunit beta OS=Bos taurus OX=9913 GN=CATSPERB PE=4 SV=4 CANONICAL=E1B9V5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX5/entry", "sequence": { "sequence": "LGKYSKIGSISDKVFTLYYDHMGFIHKLTPDHFEAGGSLAAFGNSKGIFGQAFDMGFDTALAPQYLTLNEMIFYAYVPKNEPKDRVHTKQFYDIHFGKLIHSRKTGTAYIRKVFQHNTPEGFLSSVIAELIDPFGIEEVNESSCLSSSLSISEAGNHSYKLSLQLQSVISSFQDSDIEKTVVIPGYSSFLITTILDNENALAVATMPEIVPHNMTFQKDSWFLYNFGKRNGQTWNIYAKPCNYWFQQHDDSLSLSVLKYIDLGKSHTLKMKVIPNTKLLRTLEIPLLQVIVGNPNLLEVKVEGYFDETDSYIMEVSTASKTLHQGSTSLEFIVWGASTECYVTTFVPMLKSSCSYLKSMHHIPSETIPLEDWMSGVYVNSQGFNMIKVLPINYRPPSNMGIAIPLTDHFYHADPSKPIPRNLFYKSKRSGKFKQCANATTRKECNCTNDQKFSYAVAFSDCREKVPRFKFPVIQYPVSLQVYSEDGNFPVETPYLVTVTEVNNRENWNLRHTVPENVKKMKAYLESILSVPVYNPLGLNLSIKGSELFHFRVSVVPGVSFCNLVEEFQIYVDEVPLPFPGHTLIAVAAAVLLGGLIFIAFMFQIRNIHPWDTFKKLIRRNNLVHR", "length": 625, "header": "tr|A0AAA9SEX5-1|E1B9V5_BOVIN Computationally mapped isoform of Cation channel sperm associated auxiliary subunit beta OS=Bos taurus OX=9913 GN=CATSPERB PE=4 SV=1 CANONICAL=E1B9V5-1" }, "locus": { "chromosome": "21", "start_pos": 56342579, "end_pos": 56298201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132939.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132939.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084702.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084702.1" } ] } }, { "isoform_ac": "E1B9V5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9V5/entry", "sequence": { "sequence": "FQSEVEFTTKEFLSVFTSAGLAPSLEIINSTYTGVFHFNLTLYSDRVYWLIDIPRENITKNTDIAAVEEWLVRITLQYGLNIYTTEGTLLDTVREPILHWKLGTMMKKRTIQRLYPHVVDLKTTKCPCANDVALLGFVMNTTFDGVYIGLSFSGFWDYDDTQWYNLTDMVYSQVGEEHKQLSVVDMVLTNHFLVILTSLGLFISGDLRYPSSSVLMLSRVDFCGFERVDYIKGKLWYNERCFANRELFEVDYVTITFDRNRTLSEANSCFYSKEPFLEWLPCLPPVPKGTKTILSTVITFLVDQEQSSAVYLFHNQKNTIVSVRILKHNKPDLIQKFPPFSFPSSFSSPVGMIFHPRSHFLYAYGNQVWLSIDGGNTFDLIADFHDDIIKNTYHSFYTSDITLVSQSGKVYLTKAGLGKYSKIGSISDKVFTLYYDHMGFIHKLTPDHFEAGGSLAAFGNSKGIFGQAFDMGFDTALAPQYLTLNEMIFYAYVPKNEPKDRVHTKQFYDIHFGKLIHSRKTGTAYIRKVFQHNTPEGFLSSVIAELIDPFGIEEVNESSCLSSSLSISEAGNHSYKLSLQLQSKYNDISDEKTVVIPGYSSFLITTILDNENALAVATMPEIVPHNMTFQKDSWFLYNFGKRNGQTWNIYAKPCNYWFQQHDDSLSLSVLKYIDLGKSHTLKMKVIPNTKRKTLEIPLLQVIVGNPNLLEVKVEGYFDETDITLISLHLFGYFQGSTSLEFIVWGASTECYVTTFVPMLKSSCSYLKSMHHIPSETIPLEDWMSGVYVNSQGFNMIKVLPINYRPPSNMGIAIPLTDHFYHADPSKPIPRNLFYKSKRSGKFKQCANATTRKECNCTNDQKFSYAVAFSDCREKVPRFKFPVIQYPVSLQVYSEDGNFPVETPYLVTVTEVNNRENWNLRHTVPENVKKMKAYLESILSVPVYNPLGLNLSIKGSELFHFRVSVVPGVSFCNLVEEFQIYVDEVPLPFPGHTLIAVAAAVLLGGLIFIAFMFQIRNIHPWDTFKKLIRRNNVNPTNITAN", "length": 1040, "header": "tr|E1B9V5-1|E1B9V5_BOVIN Isoform 1 of Cation channel sperm associated auxiliary subunit beta OS=Bos taurus OX=9913 GN=CATSPERB PE=4 SV=4 CANONICAL=E1B9V5-1" }, "locus": { "chromosome": "21", "start_pos": 56413423, "end_pos": 56298216, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024903.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024903.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024903.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024903.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1300642", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300642", "resource": "Reactome", "description": "Sperm Motility And Taxes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "E1B9V5", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E1B9V5", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1036, "end_pos": 1038, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" }, { "start_pos": 855, "end_pos": 857, "annotation": "n_glycosylation_sequon" }, { "start_pos": 949, "end_pos": 951, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9V5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1040, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9V5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9V5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" }, { "id": "PF22831", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22831" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CATSPERB Ig-like", "eco_id": "ECO_0000259", "start_pos": 658, "end_pos": 761, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" }, { "id": "PF22830", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22830" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CATSPERB head", "eco_id": "ECO_0000259", "start_pos": 477, "end_pos": 652, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" }, { "id": "PF21548", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21548" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cation channel sperm-associated auxiliary subunit beta 2nd", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 451, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" }, { "id": "PF21541", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21541" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cation channel sperm-associated auxiliary subunit beta N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 91, "start_aa": "Phe", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V5" }, { "id": "PF15149", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15149" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cation channel sperm-associated protein subunit beta C-terminal", "eco_id": "ECO_0000259", "start_pos": 763, "end_pos": 1020, "start_aa": "Cys", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1036, "end_pos": 1038 }, { "start_pos": 140, "end_pos": 142 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 556, "end_pos": 558 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 626, "end_pos": 628 }, { "start_pos": 847, "end_pos": 849 }, { "start_pos": 855, "end_pos": 857 }, { "start_pos": 949, "end_pos": 951 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7S0-1", "uniprot_ac": "E1B7S0", "uniprot_id": "E1B7S0_BOVIN", "mass": { "chemical_mass": 58281.0, "monoisotopic_mass": 58281.0 }, "refseq": { "ac": "NP_001178224", "name": "zinc finger protein 513", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178224" }, "gene_names": [ { "name": "ZNF513", "type": "recommended", "evidence": [ { "id": "E1B7S0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ] }, { "name": "ZNF513", "type": "synonym", "evidence": [ { "id": "NP_001178224", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178224" } ] } ], "protein_names": [ { "name": "Zinc finger protein 513", "type": "recommended", "evidence": [ { "id": "E1B7S0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S0/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 513", "type": "synonym", "evidence": [ { "id": "NP_001178224", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178224" } ] } ], "function": [ { "annotation": "Transcriptional regulator that plays a role in retinal development and maintenance.", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0#function" }, { "database": "UniProtKB", "id": "ARBA00053347", "url": "https://www.uniprot.org/uniprotkb/ARBA00053347#function" }, { "database": "UniProtKB", "id": "A0AAA9SIK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF513", "url": "https://www.uniprot.org/uniprotkb/E1B7S0", "locus": { "chromosome": "11", "start_pos": 72287407, "end_pos": 72283322, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019518", "url": "https://www.ensembl.org/id/ENSBTAG00000019518" } ] } } ], "crossref": [ { "id": "E1B7S0", "url": "https://alphafold.ebi.ac.uk/entry/E1B7S0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019518", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019518", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138621", "url": "https://www.ncbi.nlm.nih.gov/gene/100138621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050688", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050688", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138621", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138621", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SICGYSC", "url": "https://omabrowser.org/oma/group/SICGYSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7S0", "url": "https://www.orthodb.org/?gene=E1B7S0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178224", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEEEGDRNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPTRGPGEARGERPGPACQLCGGPTGEGPCCGAGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCAPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVSPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRNCGQELEEGEGSRLGAATCGRCMRGETGGSASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPPVLSSRGPTALGATSSRALHTDSP", "length": 542, "header": "tr|E1B7S0-1|E1B7S0_BOVIN Isoform 1 of Zinc finger protein 513 OS=Bos taurus OX=9913 GN=ZNF513 PE=3 SV=1 CANONICAL=E1B7S0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK3/entry", "sequence": { "sequence": "MMGSVPEGESTSSLPSSVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEEEGDRNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPTRGPGEARGERPGPACQLCGGPTGEGPCCGAGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCAPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVSPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRNCGQELEEGEGSRLGAATCGRCMRGETGGSASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKTDQKPPSPSSPAGQGAPH", "length": 510, "header": "tr|A0AAA9SIK3-1|E1B7S0_BOVIN Computationally mapped isoform of Zinc finger protein 513 OS=Bos taurus OX=9913 GN=ZNF513 PE=3 SV=1 CANONICAL=E1B7S0-1" }, "locus": { "chromosome": "11", "start_pos": 72286557, "end_pos": 72283749, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085153.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085153.1" } ] } }, { "isoform_ac": "E1B7S0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S0/entry", "sequence": { "sequence": "MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEEEGDRNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPTRGPGEARGERPGPACQLCGGPTGEGPCCGAGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCAPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVSPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRNCGQELEEGEGSRLGAATCGRCMRGETGGSASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPPVLSSRGPTALGATSSRALHTDSP", "length": 542, "header": "tr|E1B7S0-1|E1B7S0_BOVIN Isoform 1 of Zinc finger protein 513 OS=Bos taurus OX=9913 GN=ZNF513 PE=3 SV=1 CANONICAL=E1B7S0-1" }, "locus": { "chromosome": "11", "start_pos": 72286439, "end_pos": 72283504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025999.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025999.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025999.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025999.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 129, "start_aa": "Thr", "end_pos": 129, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr129", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 234, "start_aa": "Thr", "end_pos": 234, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr234", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 239, "start_aa": "Thr", "end_pos": 239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr239", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 256, "start_aa": "Thr", "end_pos": 256, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr256", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100138621", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138621", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KXF2-1", "protein_name": "Zinc finger protein 513", "gene_name": "znf513b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPRRKQSNPQPVKLGAEDGVAAGNKESLVLESDFLLGQELGFGENDYRIVGFERDSDSVAADMGMPVYGFSDEDCSSYNRLGIESDFEDPRDTESEREEMAPEAAFAPYLSCRQCGQLLGDPLSGLYCLQCGETDRQDRSLEPTHPADNTLENLNHSRSDGNTSKTFSCKLCSFSSRYSNHLKRHMKTHNGEKPYQCPHCVYASAQLVNLQRHVRTHTGEKPYKCQFCTFACNSLGNLKRHQRMHTQEKELSCAHCDFRASNSHSLKKHTKSHKEDKTTALTEESVVSDLTLHISSDPDFLQNYDHHHNHHLPSHLPPPALLHNEGLSGESDPLPELLFPFSCRVCGAVLDDEEATAPQICSKCTLDMLSKSSPDKDDKLFPCTSCPFVTQYPNHLARHMKTHSGEKPYKCPQCSYASAHFDNLKRHHRVHTGEKPYKCRVCDYACGNLANLKRHERIHSGSKPFQCSVCSYSCNQSMNLKRHMLRHTGEKPFKCQHCGYTTGHWDNYKRHQKKHGHAGGEGWIKMQLPEKEDEEEEEGEM", "length": 541 }, "evidence": [ { "id": "E1B7S0", "url": "https://omabrowser.org/oma/group/E1B7S0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5FWU5-1", "protein_name": "Zinc finger protein 513", "gene_name": "Znf513", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRRKQSHPQPVKCEGVKVDTEDSFDEGPGALVLESDLLLGQDLEFEEEEEEEEGDGHNDQLMGFERDSEGDSQGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHTGPPTPPCPTCGFRCCAPRPTRPPSPTEQEGTMPRRSEDALILPDLSLHVPPGGTSFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGTAMCGRCMRGESGGGGSGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSAPEGWAPPHSPPSVLSTRGSAALGATGSRALHTDSP", "length": 541 }, "evidence": [ { "id": "E1B7S0", "url": "https://omabrowser.org/oma/group/E1B7S0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PD29-1", "protein_name": "Zinc finger protein 513", "gene_name": "Znf513", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRRKQSHPQPVKCEGVKVDTEDSFDEGPGALVLESDLLLGQDLEFEEEEEEDEGDGHNDQLMGFERDSEGDSQGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPPLPPRLLYSCRLCAFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHTGPPTPPCPTCGFRCCAPRPTRPPSPTEQEGTMPRRSEDALILPDLSLHVPPGGASFLPDCGQLRGEGESLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGVATGGPQGPGDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSAPEGWAPPHSPPSVLSTRGPAALGATGSRALHSDSP", "length": 541 }, "evidence": [ { "id": "E1B7S0", "url": "https://omabrowser.org/oma/group/E1B7S0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N8E2-1", "protein_name": "Zinc finger protein 513", "gene_name": "ZNF513", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEGDGNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPLLPPRLLYSCRLCTFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGGASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPSVLSSRGPPALGTAGSRAVHTDSS", "length": 541 }, "evidence": [ { "id": "E1B7S0", "url": "https://omabrowser.org/oma/group/E1B7S0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1B7S0", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7S0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 542, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7S0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7S0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7S0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 151, "end_pos": 178, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 129, 234, 239, 256 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 455, "end_pos": 457 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC83-1", "uniprot_ac": "E1BC83", "uniprot_id": "E1BC83_BOVIN", "mass": { "chemical_mass": 125580.0, "monoisotopic_mass": 125580.0 }, "refseq": { "ac": "NP_001179138", "name": "regulator of G-protein signaling protein-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179138" }, "gene_names": [ { "name": "RGSL1", "type": "recommended", "evidence": [ { "id": "E1BC83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC83" } ] }, { "name": "RGSL1", "type": "synonym", "evidence": [ { "id": "NP_001179138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179138" } ] }, { "name": "RGSL2", "type": "synonym", "evidence": [ { "id": "NP_001179138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179138" } ] } ], "protein_names": [ { "name": "Regulator of G protein signaling like 1", "type": "synonym", "evidence": [ { "id": "E1BC83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC83/entry#names_and_taxonomy" } ] }, { "name": "regulator of G-protein signaling like 2", "type": "synonym", "evidence": [ { "id": "NP_001179138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179138" } ] }, { "name": "regulator of G-protein signaling protein-like", "type": "synonym", "evidence": [ { "id": "NP_001179138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179138" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC83", "url": "https://www.uniprot.org/uniprotkb/E1BC83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGSL1", "url": "https://www.uniprot.org/uniprotkb/E1BC83", "locus": { "chromosome": "16", "start_pos": 63603943, "end_pos": 63544117, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018220", "url": "https://www.ensembl.org/id/ENSBTAG00000018220" } ] } } ], "crossref": [ { "id": "E1BC83", "url": "https://alphafold.ebi.ac.uk/entry/E1BC83", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018220", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018220", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509065", "url": "https://www.ncbi.nlm.nih.gov/gene/509065", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509065", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509065", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEKMDSM", "url": "https://omabrowser.org/oma/group/MEKMDSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC83", "url": "https://www.orthodb.org/?gene=E1BC83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47079", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47079", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47079:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47079:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179138", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC83", "url": "https://www.uniprot.org/uniprotkb/E1BC83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC83-1", "url": "https://www.uniprot.org/uniprotkb/E1BC83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNAEIIGSTNLIILLEDEIFADFFNTFLSLPVFGQTPFYTVENSQWGLWPEIPHDLIAKYKGLLTWLEKYRLPFFCKANLCFHYILCQEFISFIKSPEGGEELVDFWILVEKILSIDEMDLEVRNHYLSLLFVLKATHLQESSRVVTLCNMNIKALLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHAKTVMAKEESCQALMQEYETRLYSICYTHEGGLPLNMNIKKAHQPQKHYSSRKIKRKMWHLIDCGSWSLEMDTNPDTNTVPPPELDSQDKVVIQKPFPKEASSKDRIISSPEKDVLYARKSNVKKKAKSHLHMEGLFETAFSTHLRTVTPIINYSSHVTIKKAVKQNLSLGYTHWALCADACAGSPFRDHLKKLNLKVEIQLLDLWQDLHHFLCVLMSNRKTGKAIFRHMLGNRICELYLNEQIGPCLPLKSQTIEGLKEMLPSGDVNPWIPRTQKEICKILSPWYTEFLDEEDYWFLVFTTQSRLIRTKWHKKESISKEDIILLYKRFEESLELSQGLANMEEMESMQWQKIATEDLKQGGSLRVERKSPVFLADIEKMAFEELCYKYPKVAIEKISEDYKIYCEKVPHIDFTVEIFREPKMVLPSKRRMSFFKRANVRKPSIRPRNLTEVLLNTQHLEFFREFLRERRAETPLQFLVAIQKISVETNEKIYNSLFENVIKTFFHGKNSPEQMLQCNAPLIKEVSLMHHVSTTTLLMLQGFVMRSLEEKWFKDYQELFPPQPLEKEAEIPIASPKKPSKTAVYLQESQKRGWLKMISFIRSFCNYRRFMSHPHKRQELEDYLHLEVHNKENFSTAPNISGRPMPNPSVRSTDHENGDIVLMKRRVFGHRIIIINYAVNDFYFFSEMEKFNDLVSSARVLQVNRAYNENDVILMKSKISIILKLYLHADVPPRLRVNISDAQKDAILTAISDGRLDRSIFHGAIMSVFPIIMYFWKRFCAWKAIQSYFQYMGKKFKDIIISPKPVYKHPPWSGGDQAILRFTLCRGIEWLRPQPRDAAGSSVQNSSSSIFTQSRHAISAMQLCPVPGPKLPSTKKERK", "length": 1075, "header": "tr|E1BC83-1|E1BC83_BOVIN Isoform 1 of Regulator of G protein signaling like 1 OS=Bos taurus OX=9913 GN=RGSL1 PE=4 SV=3 CANONICAL=E1BC83-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIX0/entry", "sequence": { "sequence": "MDHDTSTKRCSRPLWLFLSFLFQVFGQTPFYTVENSQWGLWPEIPHDLIAKYKGLLTWLEKYRLPFFCKANLCFHYILCQEFISFIKSPEGAKMMRWQKADQWLLEKCIGGVRGMWRFYTYLKGSAGEELVDFWILVEKILSIDEMDLEVRNHYLSLLFVLKATHLQESSRVVTLCNMNIKALLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHAKTVMAKEESCQALMQEYETRLYSICYTHEGGLPLNMNIKKAHQPQKHYSSRKIKRKMWHLIDCGSWSLEMDTNPDTNTVPPPELDSQDKVVIQKPFPKEASSKDRIISSPEKDVLYARKSNVKKKAKSHLHMEGLFETAFSTHLRTVTPIINYSSHVTIKKAVKQNLSLGYTHWALCADACAGSPFRDHLKKLNLKVEIQLLDLWQDLHHFLCVLMSNRKTGKAIFRHMLGNRICELYLNEQIGPCLPLKSQTIEGLKEMLPSGDVNPWIPRTQKEICKILSPWYTEFLDEEDYWFLVFTTQSRLIRTKWHKKESISKEDIILLYKRFEESLELSQGLANMEEMESMQWQKIATEDLKQGGSLRVERKSPVFLADIEKMAFEELCYKYPKVAIEKISEDYKIYCEKVPHIDFTVEIFREPKMVLPSKRRMSFFKRANVRKPSIRPRNLTEVLLNTQHLEFFREFLRERRAETPLQFLVAIQKISVETNEKIYNSLFENVIKTFFHGKNSPEQMLQCNAPLIKEVSLMHHVSTTTLLMLQGFVMRSLEEKWFKDYQELFPPQPLEKEAEIPIASPKKPSKTAVYLQESQKRGWLKMISFIRSFCNYRRFMSHPHKRQELEDYLHLEVHNKENFSTAPNISGRPMPNPSVRSTDHENGDIVLMKRRVFGHRIIIINYAVNDFYFFSEMEKFNDLVSSARVLQVNRAYNENDVILMKSKISIILKLYLHADVPPRLRVNISDAQKDAILTAISDGRLDRSIFHGAIMSVFPIIMYFWKRFCAWKAIQSYFQYMGKKFKDIIISPKPVYKHPPWSGGDQAILRFTLCRGIEWLRPQPRDAAGSSVQNCP", "length": 1069, "header": "tr|A0AAA9SIX0-1|E1BC83_BOVIN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Bos taurus OX=9913 GN=RGSL1 PE=4 SV=1 CANONICAL=E1BC83-1" }, "locus": { "chromosome": "16", "start_pos": 63600809, "end_pos": 63551117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082494.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082494.1" } ] } }, { "isoform_ac": "A0AAA9SPJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ6/entry", "sequence": { "sequence": "MDHDTSTKRCSRPLWLFLSFLFQVFGQTPFYTVENSQWGLWPEIPHDLIAKYKGLLTWLEKYRLPFFCKANLCFHYILCQEFISFIKSPEGGEELVDFWILVEKILSIDEMDLEVRNHYLSLLFVLKATHLQESSRVVTLCNMNIKALLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHAKTVMAKEESCQALMQEYETRLYSICYTHEGGLPLNMNIKKAHQPQKHYSSRKIKRKMWHLIDCGSWSLEMDTNPDTNTVPPPELDSQDKVVIQKPFPKEASSKDRIISSPEKDVLYARKSNVKKKAKSHLHMEGLFETAFSTHLRTVTPIINYSSHVTIKKAVKQNLSLGYTHWALCADACAGSPFRDHLKKLNLKVEIQLLDLWQDLHHFLCVLMSNRKTGKAIFRHMLGNRICELYLNEQIGPCLPLKSQTIEGLKEMLPSGDVNPWIPRTQKEICKILSPWYTEFLDEEDYWFLVFTTQSRLIRTKWHKKESISKEDIILLYKRFEESLELSQGLANMEEMESMQWQKIATEDLKQGGSLRVERKSPVFLADIEKMAFEELCYKYPKVAIEKISEDYKIYCEKVPHIDFTVEIFREPKMVLPSKRRMSFFKRANVRKPSIRPRNLTEVLLNTQHLEFFREFLRERRAETPLQFLVAIQKISVETNEKIYNSLFENVIKTFFHGKNSPEQMLQCNAPLIKEVSLMHHVSTTTLLMLQGFVMRSLEEKWFKDYQELFPPQPLEKEAEIPIASPKKPSKTAVYLQESQKRGWLKMISFIRSFCNYRRFMSHPHKRQELEDYLHLEVHNKENFSTAPNISGRPMPNPSVRSTDHENGDIVLMKRRVFGHRIIIINYAVNDFYFFSEMEKFNDLVSSARVLQVNRAYNENDVILMKSKISIILKLYLHADVPPRLRVNISDAQKDAILTAISDGRLDRSIFHGAIMSVFPIIMYFWKRFCAWKAIQSYFQYMGKKFKDIIISPKPVYKHPPWSGGDQAILRFTLCRGIEWLRPQPRDAAGSSVQNSSSSIFTQSRHAISAMQLCPVPGPKLPSTKKERK", "length": 1066, "header": "tr|A0AAA9SPJ6-1|E1BC83_BOVIN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Bos taurus OX=9913 GN=RGSL1 PE=4 SV=1 CANONICAL=E1BC83-1" }, "locus": { "chromosome": "16", "start_pos": 63602939, "end_pos": 63551117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097197.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097197.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087275.1" } ] } }, { "isoform_ac": "A0AAA9TI97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI97/entry", "sequence": { "sequence": "MDHDTSTKRCSRPLWLFLSFLFQVFGQTPFYTVENSQWGLWPEIPHDLIAKYKGLLTWLEKYRLPFFCKANLCFHYILCQEFISFIKSPEGAKMMRWQKADQWLLEKCIGGVRGMWRFYTYLKGSAGEELVDFWILVEKILSIDEMDLEVRNHYLSLLFVLKATHLQESSRVVTLCNMNIKALLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHAKTVMAKEESCQALMQEYETRLYSICYTHEGGLPLNMNIKKAHQPQKHYSSRKIKRKMWHLIDCGSWSLEMDTNPDTNTVPPPELDSQDKVVIQKPFPKEASSKDRIISSPEKDVLYARKSNVKKKAKSHLHMEGLFETAFSTHLRTVTPIINYSSHVTIKKAVKQNLSLGYTHWALCADACAGSPFRDHLKKLNLKVEIQLLDLWQDLHHFLCVLMSNRKTGKAIFRHMLGNRICELYLNEQIGPCLPLKSQTIEGLKEMLPSGDVNPWIPRTQKEICKILSPWYTEFLDEEDYWFLVFTTQSRLIRTKWHKKESISKEDIILLYKRFEESLELSQGLANMEEMESMQWQKIATEDLKQGGSLRVERKSPVFLADFTVEIFREPKMVLPSKRRMSFFKRANVRKPSIRPRNLTEVLLNTQHLEFFREFLRERRAETPLQFLVAIQKISVETNEKIYNSLFENVIKTFFHGKNSPEQMLQCNAPLIKEVSLMHHVSTTTLLMLQGFVMRSLEEKWFKDYQELFPPQPLEKEAEIPIASPKKPSKTAVYLQESQKRGWLKMISFIRSFCNYRRFMSHPHKRQELEDYLHLEVHNKENFSTAPNISGRPMPNPSVRSTDHENGDIVLMKRRVFGHRIIIINYAVNDFYFFSEMEKFNDLVSSARVLQVNRAYNENDVILMKSKISIILKLYLHADVPPRLRVNISDAQKDAILTAISDGRLDRSIFHGAIMSVFPIIMYFWKRFCAWKAIQSYFQYMGKKFKDIIISPKPVYKHPPWSGGDQAILRFTLCRGIEWLRPQPRDAAGSSVQNSSSSIFTQSRHAISAMQLCPVPGPKLPSTKKERK", "length": 1065, "header": "tr|A0AAA9TI97-1|E1BC83_BOVIN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Bos taurus OX=9913 GN=RGSL1 PE=4 SV=1 CANONICAL=E1BC83-1" }, "locus": { "chromosome": "16", "start_pos": 63602939, "end_pos": 63551117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098018.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098018.1" } ] } }, { "isoform_ac": "A0AAA9TLT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLT5/entry", "sequence": { "sequence": "MDHDTSTKRCSRPLWLFLSFLFQVFGQTPFYTVENSQWGLWPEIPHDLIAKYKGLLTWLEKYRLPFFCKANLCFHYILCQEFISFIKSPEGAKMMRWQKADQWLLEKCIGGVRGMWRFYTYLKGSAGEELVDFWILVEKILSIDEMDLEVRNHYLSLLFVLKATHLQESSRVVTLCNMNIKALLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHAKTVMAKEESCQALMQEYETRLYSICYTHEGGLPLNMNIKKAHQPQKHYSSRKIKRKMWHLIDCGSWSLEMDTNPDTNTVPPPELDSQDKVVIQKPFPKEASSKDRIISSPEKDVLYARKSNVKKKAKSHLHMEGLFETAFSTHLRTVTPIINYSSHVTIKKAVKQNLSLGYTHWALCADACAGSPFRDHLKKLNLKVEIQLLDLWQDLHHFLCVLMSNRKTGKAIFRHMLGNRICELYLNEQIGPCLPLKSQTIEGLKEMLPSGDVNPWIPRTQKEICKILSPWYTEFLDEEDYWFLVFTTQSRLIRTKWHKKESISKEDIILLYKRFEESLELSQGLANMEEMESMQWQKIATEDLKQGGSLRVERKSPVFLADIEKMAFEELCYKYPKVAIEKISEDYKIYCEKVPHIDFTVEIFREPKMVLPSKRRMSFFKRANVRKPSIRPRNLTEVLLNTQHLEFFREFLRERRAETPLQFLVAIQKISVETNEKIYNSLFENVIKTFFHGKNSPEQMLQCNAPLIKEVSLMHHVSTTTLLMLQGFVMRSLEEKWFKDYQELFPPQPLEKEAEIPIASPKKPSKTAVYLQESQKRGWLKMISFIRSFCNYRRFMSHPHKRQELEDYLHLEVHNKENFSTAPNISGRPMPNPSVRSTDHENGDIVLMKRRVFGHRIIIINYAVNDFYFFSEMEKFNDLVSSARVLQVNRAYNENDVILMKSKISIILKLYLHADVPPRLRVNISDAQKDAILTAISDGRLDRSIFHGAIMSVFPIIMYFWKRFCAWKAIQSYFQYMGKKFKDIIISPKPVYKHPPWSGGDQAILRFTLCRGIEWLRPQPRDAAGSSVQNSSSSIFTQSRHAISAMQLCPVPGPKLPSTKKERK", "length": 1101, "header": "tr|A0AAA9TLT5-1|E1BC83_BOVIN Computationally mapped isoform of Regulator of G protein signaling like 1 OS=Bos taurus OX=9913 GN=RGSL1 PE=4 SV=1 CANONICAL=E1BC83-1" }, "locus": { "chromosome": "16", "start_pos": 63602939, "end_pos": 63551117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102730.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102730.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098189.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098189.1" } ] } }, { "isoform_ac": "E1BC83-1", "url": "https://www.uniprot.org/uniprotkb/E1BC83/entry", "sequence": { "sequence": "MSNAEIIGSTNLIILLEDEIFADFFNTFLSLPVFGQTPFYTVENSQWGLWPEIPHDLIAKYKGLLTWLEKYRLPFFCKANLCFHYILCQEFISFIKSPEGGEELVDFWILVEKILSIDEMDLEVRNHYLSLLFVLKATHLQESSRVVTLCNMNIKALLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHAKTVMAKEESCQALMQEYETRLYSICYTHEGGLPLNMNIKKAHQPQKHYSSRKIKRKMWHLIDCGSWSLEMDTNPDTNTVPPPELDSQDKVVIQKPFPKEASSKDRIISSPEKDVLYARKSNVKKKAKSHLHMEGLFETAFSTHLRTVTPIINYSSHVTIKKAVKQNLSLGYTHWALCADACAGSPFRDHLKKLNLKVEIQLLDLWQDLHHFLCVLMSNRKTGKAIFRHMLGNRICELYLNEQIGPCLPLKSQTIEGLKEMLPSGDVNPWIPRTQKEICKILSPWYTEFLDEEDYWFLVFTTQSRLIRTKWHKKESISKEDIILLYKRFEESLELSQGLANMEEMESMQWQKIATEDLKQGGSLRVERKSPVFLADIEKMAFEELCYKYPKVAIEKISEDYKIYCEKVPHIDFTVEIFREPKMVLPSKRRMSFFKRANVRKPSIRPRNLTEVLLNTQHLEFFREFLRERRAETPLQFLVAIQKISVETNEKIYNSLFENVIKTFFHGKNSPEQMLQCNAPLIKEVSLMHHVSTTTLLMLQGFVMRSLEEKWFKDYQELFPPQPLEKEAEIPIASPKKPSKTAVYLQESQKRGWLKMISFIRSFCNYRRFMSHPHKRQELEDYLHLEVHNKENFSTAPNISGRPMPNPSVRSTDHENGDIVLMKRRVFGHRIIIINYAVNDFYFFSEMEKFNDLVSSARVLQVNRAYNENDVILMKSKISIILKLYLHADVPPRLRVNISDAQKDAILTAISDGRLDRSIFHGAIMSVFPIIMYFWKRFCAWKAIQSYFQYMGKKFKDIIISPKPVYKHPPWSGGDQAILRFTLCRGIEWLRPQPRDAAGSSVQNSSSSIFTQSRHAISAMQLCPVPGPKLPSTKKERK", "length": 1075, "header": "tr|E1BC83-1|E1BC83_BOVIN Isoform 1 of Regulator of G protein signaling like 1 OS=Bos taurus OX=9913 GN=RGSL1 PE=4 SV=3 CANONICAL=E1BC83-1" }, "locus": { "chromosome": "16", "start_pos": 63602939, "end_pos": 63544117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044259.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044259.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041768.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041768.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509065", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509065", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LJ40-1", "protein_name": "Regulator of G-protein signaling like 1", "gene_name": "Rgsl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESGWNPAATSLCAHILFLTNPCQEEHGNMSNAEIICSTNLIILLEDETFADFFNTFLSLPVFGQTPFYNVELSQWSLWPEIPYDLITKYKGLLTWLEKYRLPFFCKTNLCFYYILCQELISFVKSPEGAKMMRWKMADQWLLEKCIAGVRGMWRFCSYLKGSAGEELLDFWVLAEKILSIDETDEYLKDYYLSLLLVLKATHLQEGSRVVTLCNMDIKSLLNLSIWHPNQSTTRREILSHMQKVALFKIQSYWLPNFYTHAKMTMANEEACHGLLQEYETRLCSVCCTHAGGLPLNMSIKKSHRSQKKYSSKKAKKKMWHLNNPIFWPLETDPKPEVPTKAPEEMSLPERVVLQKPSLGEDSSKETVVHPLCKDLQNAKKPIVKKKSKIQLHMEGLLETTFSNHLRTSTPMINHAAPLVVKKSLKRSLSFGYTHWALCADACAGSPFRYHLKKMNLKAEVQLLDLWQDLQHFVSVLMTNRQNGNALFRHVLGNRICELYLNEQIGPPLPLKPQTLQGLKKLLPSGEVNPWIPKAQREICKMLSSRYDEFLMEEDYWFLVFTTQTRFIKARWYKREAINKEEHVLLYKRLQESLLLSQALANIQEIDSIQWQKVATENLRQGGSLQVELTTPVFLQDTSKMSFKDLSFKNPKLAIEKMSEDYKIYCERVPPTDFTVEIIKQPRVSYSQRKISFAKRSVIRKPSMRPRNMTEILLNNAHLEYFREFLKDRKSENPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPPEEILQCDAPFVKEVVNTRHITTTTLLMLQGIIMKSVEEKWFKEYQDLFPPRPVEVEPVETHVVPRKPSKTITTHLHDSQKRGWIKMISFIKSFCKYRRFVTNAKNLQELTDFIYLEMYNNKENFSSSPTPSARHTPIYPSARNTEPENGEIALVKRRIFGHRIITINFAVNDIYFFSEMEKFNDLVTSAHMLQVNKAYNENDIVLMRSKLNIILKLYLISDLPPKLRVNISESQKDIIFSAITEGHLDRTIFHGAIMSVFPVVMYFWKRFCSWKATRSYIEYIGKKFEDGRNPPKSVYKYPPWSGGDHTVLRFSLLRGIEWFRPQHPRDVLTNSLQNYQKYPKKKKRKNNHAKSRTEVDDSLSASQY", "length": 1138 }, "evidence": [ { "id": "E1BC83", "url": "https://omabrowser.org/oma/group/E1BC83/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A5PLK6-1", "protein_name": "Regulator of G protein signaling protein-like", "gene_name": "RGSL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK", "length": 1076 }, "evidence": [ { "id": "E1BC83", "url": "https://omabrowser.org/oma/group/E1BC83/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "H3BL40-1", "protein_name": "Regulator of G-protein signaling like 1", "gene_name": "Rgsl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNADIICSTNLIILLEDETFADFFNTFLSLPVFGQTPFYNVEKSQWSLWPEVPYDLIAKYKGLLTWLEKYRLPFFCKTNLCFYYILSQELVSFLKSPEGGEELLDFWILAEKILSIDETDKYLKDYYLSLLLVLKATHLQEGSRVVTLCNMDIKSLLNLSIWHPNQSTTRREILSHMQKVALFKIQSYWLPNFYTHAKMTMANEEACHGLMQEYETRLYSVCCAHAGGLPLNMSIKKSRHSQKKYSSKKAKKKIWHLNNPILWPLETDAKPEVPTKPQEELSLPERVVLQKTSLGEDSSKETIIHSLCKDLQNAKKPIVKKKSKIQLHMEGFLETAFTNHLRSSTPIINHAAPLVVKKSLKRSLSFGYTHWALCADACAGSPFRFHLKKMNLKVEVQLLDLWQDLQHFISVLMNNRQNGNALFRHMLGNRICELYLNEQIGPPLPLKPQTLQGLKKLLPSGEVNPWIPKAQREICKVLSPWYDEFLMEEDYWFLIFTTQTRFAKARWHKRETISKEEHILLYKRLQESLVLSQALASMQEIDSMQWQKVATENLRQGGSLQVELTTPVFLQDISKMSFKDLSFKNPKLAIEKMSEDYKIYCEKVPPTAFTVEIIRQPKYSYSQRKTSFVKKSVVRKPSMRPRNLTEVLLNNAHLEYFKEFLKDRKSESPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPAEEILQCDAPFIKEIANVRHITTTTLLMLQGYVMKSVEEKWFKEYQDLFPPRSVEFEFVEAQAVPRKPSKSTTHLHDSQKRGWIKMIAFIKSFCNYRRFIADANNRQELADFIYLEMFNNKENFSTSPATSARHTPVNLSARNAEQENGDTVLVKRRIFGHRIITINFAVNDMYLFSEMERFNDLVSSAHMLQINRAYNENDIILMRSKLNIIVKLYLVSDLPPKLKVNISESQKDIIISAITEGHLDRTIFHGAIMSIFPVIMYFWKRFCNWKATRSYVEYLGKKFEDGRNPPKSVYKYPPWSGGEHTVLRFSLLRGVEWFRPQHPRDAVPSSLQPYQKYPTTKKRRSNQAKAKADMDGPLTLSQY", "length": 1073 }, "evidence": [ { "id": "E1BC83", "url": "https://omabrowser.org/oma/group/E1BC83/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1041, "end_pos": 1043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 645, "end_pos": 647, "annotation": "n_glycosylation_sequon" }, { "start_pos": 829, "end_pos": 831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 835, "end_pos": 837, "annotation": "n_glycosylation_sequon" }, { "start_pos": 934, "end_pos": 936, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC83" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 645, "end_pos": 702, "start_aa": "Asn", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1041, "end_pos": 1043 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 645, "end_pos": 647 }, { "start_pos": 829, "end_pos": 831 }, { "start_pos": 835, "end_pos": 837 }, { "start_pos": 934, "end_pos": 936 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QQL5-1", "uniprot_ac": "A6QQL5", "uniprot_id": "CMIP6_BOVIN", "mass": { "chemical_mass": 32740.0, "monoisotopic_mass": 32740.0 }, "refseq": { "ac": "NP_001094753", "name": "ciliary microtubule inner protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094753" }, "gene_names": [ { "name": "C11H2orf73", "type": "recommended", "evidence": [ { "id": "A6QQL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQL5" } ] }, { "name": "CIMIP6", "type": "recommended", "evidence": [ { "id": "A6QQL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQL5" } ] }, { "name": "C11H2orf73", "type": "synonym", "evidence": [ { "id": "NP_001094753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094753" } ] }, { "name": "CIMIP6", "type": "synonym", "evidence": [ { "id": "NP_001094753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094753" } ] } ], "protein_names": [ { "name": "Ciliary microtubule inner protein 6", "type": "recommended", "evidence": [ { "id": "A6QQL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQL5/entry#names_and_taxonomy" } ] }, { "name": "ciliary microtubule inner protein 6", "type": "synonym", "evidence": [ { "id": "NP_001094753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094753" } ] }, { "name": "uncharacterized protein C2orf73 homolog", "type": "synonym", "evidence": [ { "id": "NP_001094753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094753" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQL5", "url": "https://www.uniprot.org/uniprotkb/A6QQL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIMIP6", "url": "https://www.uniprot.org/uniprotkb/A6QQL5", "locus": {} } ], "crossref": [ { "id": "A6QQL5", "url": "https://alphafold.ebi.ac.uk/entry/A6QQL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006861", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006861", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782317", "url": "https://www.ncbi.nlm.nih.gov/gene/782317", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782317", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782317", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RNDFQKP", "url": "https://omabrowser.org/oma/group/RNDFQKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQL5", "url": "https://www.orthodb.org/?gene=A6QQL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35087", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35087", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35087:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35087:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15667", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15667", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094753", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SLR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQL5", "url": "https://www.uniprot.org/uniprotkb/A6QQL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQL5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGKEDKQQQHKIEDAGILYVTEKEEFKHEKKPGKSIQHSKPCVGRGRVYYAKFINTNVRTCNEPVPYIDVKKEPENQGDWWPHGKGLENPFQPPYDTKSTQRSDFKKPTCPLVSPVKHSKLQKPSYGIVPLVSPDASAELQRNFKEHISFIHQYDARKTPNEPIRGKRHGVFVQTEIKPGSRPTVPERTEVLLNASGSCSSEQSKKTEKGNSAESKMISPGLCRQNSQELLETKTHLSETDIRVAANASLRRPEKREKTAKVFQIAVVNALLTRHDPLSPPIKSQDKSG", "length": 290, "header": "sp|A6QQL5-1|CMIP6_BOVIN Isoform 1 of Ciliary microtubule inner protein 6 OS=Bos taurus OX=9913 GN=CIMIP6 PE=2 SV=1 CANONICAL=A6QQL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR0/entry", "sequence": { "sequence": "LEAKNDEIELHKIEDAGILYVTEKEEFKHEKKPGKSIQHSKPCVGRGRVYYAKFINTNVRTCNEPVPYIDVKKEPENQGDWWPHGKGLENPFQPPYDTKSTQRSDFKKPTCPLVSPVKHSKLQKPSYGIVPLVSPDASAELQRNFKEHISFIHQYDARKTPNEPIRGKRHGVFVQTEIKPGSRPTVPERTEVLLNASGSCSSEQSKKTEKGNSAESKMISPGLCRQNSQELLETKTHLSETDIRVAANASLRRPEKREKTAKVFQIAVVNALLTRHDPLSPPIKSQDKSG", "length": 290, "header": "tr|A0AAA9SLR0-1|CMIP6_BOVIN Computationally mapped isoform of Ciliary microtubule inner protein 6 OS=Bos taurus OX=9913 GN=CIMIP6 PE=2 SV=1 CANONICAL=A6QQL5-1" }, "locus": { "chromosome": "11", "start_pos": 37061553, "end_pos": 37038798, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096209.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096209.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086188.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086188.1" } ] } }, { "isoform_ac": "A6QQL5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL5/entry#A6QQL5-1", "sequence": { "sequence": "MEGKEDKQQQHKIEDAGILYVTEKEEFKHEKKPGKSIQHSKPCVGRGRVYYAKFINTNVRTCNEPVPYIDVKKEPENQGDWWPHGKGLENPFQPPYDTKSTQRSDFKKPTCPLVSPVKHSKLQKPSYGIVPLVSPDASAELQRNFKEHISFIHQYDARKTPNEPIRGKRHGVFVQTEIKPGSRPTVPERTEVLLNASGSCSSEQSKKTEKGNSAESKMISPGLCRQNSQELLETKTHLSETDIRVAANASLRRPEKREKTAKVFQIAVVNALLTRHDPLSPPIKSQDKSG", "length": 290, "header": "sp|A6QQL5-1|CMIP6_BOVIN Isoform 1 of Ciliary microtubule inner protein 6 OS=Bos taurus OX=9913 GN=CIMIP6 PE=2 SV=1 CANONICAL=A6QQL5-1" }, "locus": { "chromosome": "11", "start_pos": 37061553, "end_pos": 37035313, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009010.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009010.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009010.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009010.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782317", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782317", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QLI1-1", "protein_name": "Chromosome 3 C2orf73 homolog", "gene_name": "C3H2orf73", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTSELRYRRQHKIEDAGIPYITEKKEEINDEKKPGKSIQHSKPCVRRGRVCYAKFINTNARTCNEPVPYMDPKNEPENQGDWWSHGKGLENPFQPPYDTKSTQRSDFQKPACPLVSPVKHSKLQKPSYGIVPLASLDTSAECQKNFIERISFIHQYDARKTPNEPIRGKRHGVFVQTEIKPGSRPIVPKRTEVLLNAPGLCSSEWSQKTEKGNSAESKMISPGLCRQNSQELLETKTHLSETDVREAANACPRSPERREKIADPYQITAVNALLTSHAPLNPPGKCQDKSG", "length": 292 }, "evidence": [ { "id": "A6QQL5", "url": "https://omabrowser.org/oma/group/A6QQL5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A4P5-1", "protein_name": "Similar to human chromosome 2 open reading frame 73", "gene_name": "Cimip6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGEEKQQQHKIEDADIACVTEKKEEIKNEKSPEESTQQSKPCVDRRRVNYAKFIYTNARTYNDPVPYIDNKGPEKQRKWWFHDEAPTYVSQPSYDTNSIQRSDFQKPACPLVLPVKHSKMQKPSYGIVPLTSLDVSEEHEDNFVEYISFIHQYDSRRTPNEPIRGKRHGTFVQRKIKPETMPIAPKGPEVLLNTPGSGSSEQPQKTDKGNSSGDNVTSPRLCQKNSQELLET", "length": 233 }, "evidence": [ { "id": "A6QQL5", "url": "https://omabrowser.org/oma/group/A6QQL5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SPV6-1", "protein_name": "Ciliary microtubule inner protein 6", "gene_name": "Cimip6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGEEKQQQHKTEDDGIACVAERKVEIKNEKSPGKSTQHPKPCVDRRRVNYAKFIHTNARTYNEPVPYIDNKGPEKQRKWWFHNEAPKHVSQPSYDTKSVQRSDFQKPACPLVLPVKHSRMQKPSCGIVPLTSLDVSGEHENNFVEYISFIHQYDARRTPNEPIKGKKHGTFVQREIKLGAMPIVPKAPEVLLNTLESGSSEQPQKTDKGNSSGDKVTSPGLCQQNSQELLET", "length": 233 }, "evidence": [ { "id": "A6QQL5", "url": "https://omabrowser.org/oma/group/A6QQL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N5S3-1", "protein_name": "Ciliary microtubule inner protein 6", "gene_name": "CIMIP6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEKEDKHQQHKIEDAAITYVSENEEIKHEEKPGKSIHHSKSHVGRGRIYYAKFINTNARTYNEPFPYIDPKKGPEIQGDWWSHGKALEPVFLPPYDSKSTQRSDFQKPSCPLVLPVKHSKMQKPSCGIVPLASPGTSAELQNNFIEYISFIHQYDARKTPNEPLQGKRHGAFVQREIKPGSRPTVPKGAEVLLNTPGSRSSEQSKKTEKGNSAESRMISPGLCQQNSQELLEPKTHLSETDVRQAAKACPSTPESREKTSGATQTTVGDALFTRHKPLNPPIKKSE", "length": 287 }, "evidence": [ { "id": "A6QQL5", "url": "https://omabrowser.org/oma/group/A6QQL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A6QQL5", "url": "https://www.uniprot.org/uniprotkb/A6QQL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQL5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 248, "end_pos": 250 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B823-1", "uniprot_ac": "E1B823", "uniprot_id": "E1B823_BOVIN", "mass": { "chemical_mass": 15250.0, "monoisotopic_mass": 15250.0 }, "refseq": { "ac": "XP_024843404", "name": "prostate and testis expressed protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843404" }, "gene_names": [ { "name": "PATE2", "type": "recommended", "evidence": [ { "id": "E1B823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B823" } ] }, { "name": "PATE2", "type": "synonym", "evidence": [ { "id": "XP_024843404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843404" } ] } ], "protein_names": [ { "name": "Prostate and testis expressed 2", "type": "synonym", "evidence": [ { "id": "E1B823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B823/entry#names_and_taxonomy" } ] }, { "name": "prostate and testis expressed protein 2", "type": "synonym", "evidence": [ { "id": "XP_024843404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843404" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B823", "url": "https://www.uniprot.org/uniprotkb/E1B823" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PATE2", "url": "https://www.uniprot.org/uniprotkb/E1B823", "locus": { "chromosome": "29", "start_pos": 29193124, "end_pos": 29198311, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033375", "url": "https://www.ensembl.org/id/ENSBTAG00000033375" } ] } } ], "crossref": [ { "id": "E1B823", "url": "https://alphafold.ebi.ac.uk/entry/E1B823", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033375", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033375", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100294754", "url": "https://www.ncbi.nlm.nih.gov/gene/100294754", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100294754", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100294754", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR47884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47884:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47884:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024843404", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843404", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B823", "url": "https://www.uniprot.org/uniprotkb/E1B823", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B823-1", "url": "https://www.uniprot.org/uniprotkb/E1B823-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEINQGLPQATAHDQSPRMSVLFLLHIVIVVCMSKGEFYEHMKEPSTMCYKCKKYHLGICYEAMRSCTLKYKQTCAVENIYVLTRKGRSMYFYSKLSCKANCEDINFLSFEKRTELICCKHKSYCNLPEGV", "length": 131, "header": "tr|E1B823-1|E1B823_BOVIN Isoform 1 of Prostate and testis expressed 2 OS=Bos taurus OX=9913 GN=PATE2 PE=4 SV=3 CANONICAL=E1B823-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK5/entry", "sequence": { "sequence": "MEINQGLPQATAHDQSPRMSVLFLLHIVIVVCMSKGEFYEHMKGRSMYFYSKLSCKANCEDINFLSFEKRTELICCKHKSYCNLPEGV", "length": 88, "header": "tr|A0AAA9SMK5-1|E1B823_BOVIN Computationally mapped isoform of Prostate and testis expressed 2 OS=Bos taurus OX=9913 GN=PATE2 PE=4 SV=1 CANONICAL=E1B823-1" }, "locus": { "chromosome": "29", "start_pos": 29194606, "end_pos": 29193261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109717.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109717.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085180.1" } ] } }, { "isoform_ac": "E1B823-1", "url": "https://www.uniprot.org/uniprotkb/E1B823/entry", "sequence": { "sequence": "MEINQGLPQATAHDQSPRMSVLFLLHIVIVVCMSKGEFYEHMKEPSTMCYKCKKYHLGICYEAMRSCTLKYKQTCAVENIYVLTRKGRSMYFYSKLSCKANCEDINFLSFEKRTELICCKHKSYCNLPEGV", "length": 131, "header": "tr|E1B823-1|E1B823_BOVIN Isoform 1 of Prostate and testis expressed 2 OS=Bos taurus OX=9913 GN=PATE2 PE=4 SV=3 CANONICAL=E1B823-1" }, "locus": { "chromosome": "29", "start_pos": 29194606, "end_pos": 29193261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047477.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047477.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044683.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044683.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100294754", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100294754", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B823", "url": "https://www.uniprot.org/uniprotkb/E1B823" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B823-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 131, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B823-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B823" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B823" }, { "id": "PF00021", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UPAR/Ly6", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 127, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA85-1", "uniprot_ac": "E1BA85", "uniprot_id": "E1BA85_BOVIN", "mass": { "chemical_mass": 66309.0, "monoisotopic_mass": 66309.0 }, "refseq": { "ac": "XP_059730635", "name": "protein Atg16l2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730635" }, "gene_names": [ { "name": "ATG16L2", "type": "recommended", "evidence": [ { "id": "E1BA85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ] }, { "name": "ATG16L2", "type": "synonym", "evidence": [ { "id": "XP_059730635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730635" } ] } ], "protein_names": [ { "name": "Protein Atg16l2", "type": "recommended", "evidence": [ { "id": "E1BA85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA85/entry#names_and_taxonomy" } ] }, { "name": "APG16-like 2", "type": "synonym", "evidence": [ { "id": "E1BA85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA85/entry#names_and_taxonomy" } ] }, { "name": "Autophagy-related protein 16-2", "type": "synonym", "evidence": [ { "id": "E1BA85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA85/entry#names_and_taxonomy" } ] }, { "name": "protein Atg16l2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059730635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730635" } ] } ], "function": [ { "annotation": "May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85#function" }, { "database": "UniProtKB", "id": "ARBA00053879", "url": "https://www.uniprot.org/uniprotkb/ARBA00053879#function" }, { "database": "UniProtKB", "id": "A0ABI0P4Z1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Z1#function" }, { "database": "UniProtKB", "id": "A0AAA9TWB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWB9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATG16L2", "url": "https://www.uniprot.org/uniprotkb/E1BA85", "locus": { "chromosome": "15", "start_pos": 52368682, "end_pos": 52351638, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019059", "url": "https://www.ensembl.org/id/ENSBTAG00000019059" } ] } } ], "crossref": [ { "id": "E1BA85", "url": "https://alphafold.ebi.ac.uk/entry/E1BA85", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019059", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019059", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22887", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22887", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511036", "url": "https://www.ncbi.nlm.nih.gov/gene/511036", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511036", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511036", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BA85", "url": "https://www.orthodb.org/?gene=E1BA85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19878", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19878", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19878:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19878:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08614", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08614", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059730635", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4Z1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA85-1", "url": "https://www.uniprot.org/uniprotkb/E1BA85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGPGVLGAPAARWKRHIVRQLRQRDRTQKALFLELVPAYNRLLEKAELLARFSEELQPEPDDVTLSVHQGPWEKESHQGLSPAALRVKWQEEVEGLRLVCGEMAYQVVEKSATLGTLESQLEERQSRLAALKARVEQLEEVRAKKAGQVHARRALNEEQRAAYEALRARVGHQEAALRRLEEEARDLLERLVQHKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISESPDTLGDGIREEAETLVVAAKPGSLESEAGEKWKRPFSFKKRRGHSIGGAPEQRYQSIPVYVTTRLPTQAHDVLDAHLSEVSAVRFGPNSSLLATGGADRLILLWNVVGGHLKANQTLEGAGGSITSVDFDPSGSQLLAATYNKAAQLWKVGEAQSKETLSGHTDKVTAAKFKLTRHQAVTGSRDRTVKEWDLCRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPRCTQVIPVQGRVTSLSLSHDQLHLLSCSRDDTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSWDGALYIWNVDTGKLESSLRGPHSAAVNAVAWCYSGNHVVSVDQARKVVLWH", "length": 595, "header": "tr|E1BA85-1|E1BA85_BOVIN Isoform 1 of Protein Atg16l2 OS=Bos taurus OX=9913 GN=ATG16L2 PE=3 SV=2 CANONICAL=E1BA85-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX6/entry", "sequence": { "sequence": "MEGPGVLGAPAARWKRHIVRQLRQRDRTQKALFLELVPAYNRLLEKAELLARFSEELQPEPDDVTLSVHQGPWEKESHQGLSPAALRVKWQEEVEGLRLVCGEMAYQVVEKSATLGTLESQLEERQSRLAALKARVEQLEEVRAKKAGQVHARRALNEEQRAAYEALRARVGHQEAALRRLEEEARDLLERLVQHKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISESPDTLGDGIREEAETLVVAAKPGSLESEAGEKWKRPFRSASATSLTMSRCVDVVKGLLDFKKRRGHSIGGAPEQRYQSIPVYVTTRLPTQAHDVLDAHLSEVSAVRFGPNSSLLATGGADRLILLWNVVGGHLKANQTLEGAGGSITSVDFDPSGSQLLAATYNKAAQLWKVGEAQSKETLSGHTDKVTAAKFKLTRHQAVTGSRDRTVKEWDLCRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSSIRVFSNESALHMRWPKYWSFSFSISPSSEHPGLNSFGWTGWISLESKGLSRVFSNTTVPTQSPLFSQKEPKSPASGLNGL", "length": 568, "header": "tr|A0AAA9SMX6-1|E1BA85_BOVIN Computationally mapped isoform of Protein Atg16l2 OS=Bos taurus OX=9913 GN=ATG16L2 PE=3 SV=1 CANONICAL=E1BA85-1" }, "locus": { "chromosome": "15", "start_pos": 52365821, "end_pos": 52351651, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121998.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121998.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087702.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087702.1" } ] } }, { "isoform_ac": "A0AAA9TWB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWB9/entry", "sequence": { "sequence": "MEGPGVLGAPAARWKRHIVRQLRQRDRTQKALFLELVPAYNRLLEKAELLARFSEELQPEPDDVTLSVHQGPWEKESHQGLSPAALRVKWQEEVEGLRLVCGEMAYQVVEKSATLGTLESQLEERQSRLAALKARVEQLEEVRAKKAGQVHARRALNEEQRAAYEALRARVGHQEAALRRLEEEARDLLERLVQHKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISESPDTLGDGIREEAETLVVAAKPGSLESEAGEKWKRPFRSASATSLTMSRCVDVVKGLLDFKKRRGHSIGGAPEQRYQSIPVYVTTRLPTQAHDVLDAHLSEVSAVRFGPNSSLLATGGADRLILLWNVVGGHLKANQTLEGAGGSITSVDFDPSGSQLLAATYNKAAQLWKVGEAQSKETLSGHTDKVTAAKFKLTRHQAVTGSRDRTVKEWDLCRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPRCTQVIPVQGRVTSLSLSHDQLHLLSCSRDDTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSWDGALYIWNVDTGKLESSLRGPHSAAVNAVAWCYSGNHVHLGNGEASGWRHMETQAWFQSLPYRAGAERSDQETAGRKAQRQQRAVVLEPWTFLLCSKIVLVLGPSLQVPRVD", "length": 677, "header": "tr|A0AAA9TWB9-1|E1BA85_BOVIN Computationally mapped isoform of Protein Atg16l2 OS=Bos taurus OX=9913 GN=ATG16L2 PE=3 SV=1 CANONICAL=E1BA85-1" }, "locus": { "chromosome": "15", "start_pos": 52367678, "end_pos": 52351651, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099202.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099202.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101475.1" } ] } }, { "isoform_ac": "A0ABI0P4Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Z1/entry", "sequence": { "sequence": "MEGPGVLGAPAARWKRHIVRQLRQRDRTQKALFLELVPAYNRLLEKAELLARFSEELQPEPDDVTLSVHQGPWEKESHQGLSPAALRVKWQEEVEGLRLVCGEMAYQVVEKSATLGTLESQLEERQSRLAALKARVEQLEEVRAKKAGQVHARRALNEEQRAAYEALRARVGHQEAALRRLEEEARDLLERLVQHKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISESPDTLGDGIREEAETLVVAAKPGSLESEAGEKWKRPFRSASATSLTMSRCVDVVKGLLDFKKRRGHSIGGAPEQRYQSIPVYVTTRLPTQAHDVLDAHLSEVSAVRFGPNSSLLATGGADRLILLWNVVGGHLKANQTLEGAGGSITSVDFDPSGSQLLAATYNKAAQLWKVGEAQSKETLSGHTDKVTAAKFKLTRHQAVTGSRDRTVKEWDLCRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPRCTQVIPVQGRVTSLSLSHDQLHLLSCSRDDTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSWDGALYIWNVDTGKLESSLRGPHSAAVNAVAWCYSGNHVVSVDQARKVVLWH", "length": 616, "header": "tr|A0ABI0P4Z1-1|A0ABI0P4Z1_BOVIN Computationally mapped isoform of Protein Atg16l2 OS=Bos taurus OX=9913 GN=ATG16L2 PE=3 SV=1 CANONICAL=E1BA85-1" }, "locus": { "chromosome": "15", "start_pos": 52367161, "end_pos": 52351651, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154010.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154010.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105889.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105889.1" } ] } }, { "isoform_ac": "E1BA85-1", "url": "https://www.uniprot.org/uniprotkb/E1BA85/entry", "sequence": { "sequence": "MEGPGVLGAPAARWKRHIVRQLRQRDRTQKALFLELVPAYNRLLEKAELLARFSEELQPEPDDVTLSVHQGPWEKESHQGLSPAALRVKWQEEVEGLRLVCGEMAYQVVEKSATLGTLESQLEERQSRLAALKARVEQLEEVRAKKAGQVHARRALNEEQRAAYEALRARVGHQEAALRRLEEEARDLLERLVQHKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISESPDTLGDGIREEAETLVVAAKPGSLESEAGEKWKRPFSFKKRRGHSIGGAPEQRYQSIPVYVTTRLPTQAHDVLDAHLSEVSAVRFGPNSSLLATGGADRLILLWNVVGGHLKANQTLEGAGGSITSVDFDPSGSQLLAATYNKAAQLWKVGEAQSKETLSGHTDKVTAAKFKLTRHQAVTGSRDRTVKEWDLCRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPRCTQVIPVQGRVTSLSLSHDQLHLLSCSRDDTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSWDGALYIWNVDTGKLESSLRGPHSAAVNAVAWCYSGNHVVSVDQARKVVLWH", "length": 595, "header": "tr|E1BA85-1|E1BA85_BOVIN Isoform 1 of Protein Atg16l2 OS=Bos taurus OX=9913 GN=ATG16L2 PE=3 SV=2 CANONICAL=E1BA85-1" }, "locus": { "chromosome": "15", "start_pos": 52367161, "end_pos": 52351651, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025375.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025375.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025375.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025375.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511036", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511036", "resource": "KEGG Pathway" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "pmid": "" }, { "name": "Atg12-Atg5-Atg16 complex", "id": "GO:0034274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034274", "evidence": [ { "database": "UniProtKB", "id": "E1BA85", "url": "https://www.uniprot.org/uniprotkb/E1BA85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA85" }, { "id": "PF08614", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08614" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Autophagy-related protein 16", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 204, "start_aa": "His", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 323, "end_pos": 325 }, { "start_pos": 349, "end_pos": 351 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B848-1", "uniprot_ac": "E1B848", "uniprot_id": "E1B848_BOVIN", "mass": { "chemical_mass": 31197.0, "monoisotopic_mass": 31197.0 }, "refseq": {}, "gene_names": [ { "name": "UBALD2", "type": "recommended", "evidence": [ { "id": "E1B848", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B848" } ] } ], "protein_names": [ { "name": "UBA like domain containing 2", "type": "synonym", "evidence": [ { "id": "E1B848", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B848/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B848", "url": "https://www.uniprot.org/uniprotkb/E1B848" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBALD2", "url": "https://www.uniprot.org/uniprotkb/E1B848", "locus": { "chromosome": "19", "start_pos": 55443081, "end_pos": 55449360, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013792", "url": "https://www.ensembl.org/id/ENSBTAG00000013792" } ] } } ], "crossref": [ { "id": "E1B848", "url": "https://alphafold.ebi.ac.uk/entry/E1B848", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013792", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013792", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B848", "url": "https://www.orthodb.org/?gene=E1B848", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31993", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31993", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31993:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31993:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B848", "url": "https://www.uniprot.org/uniprotkb/E1B848", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B848-1", "url": "https://www.uniprot.org/uniprotkb/E1B848-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGSPTAPTSANGRGQAKRETVRARRPQDSNRTSAREPGPGRAERANQRRRLSAPERWDTRPRPALLFVVSAGSASRTTTLARRAARRPRVRRPRAAAASSSGGQPASRGRRARECAPAGAMSVNMDELRHQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIPNGHHHHQMQMCTPSNTPATPPNFPDALAMFSKLRASEGLQSSNSPMTAVACSPPANFSPFWASSPPSHQAAWIPPSSPTAHSFHHLHHPQPTWPPGAQQASTQQKAMAAMDGQR", "length": 288, "header": "tr|E1B848-1|E1B848_BOVIN Isoform 1 of UBA like domain containing 2 OS=Bos taurus OX=9913 GN=UBALD2 PE=3 SV=2 CANONICAL=E1B848-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQL8/entry", "sequence": { "sequence": "MLPTWQGPGGAGVVCHPWCLQGGCQLRHTSLAPALPGWSPCSGLWQKTAEMCTPSNTPATPPNFPDALAMFSKLRASEGLQSSNSPMTAVACSPPANFSPFWASSPPSHQAAWIPPSSPTAHSFHHLHHPQPTWPPGAQQASTQQKAMAAMDGQR", "length": 155, "header": "tr|A0AAA9SQL8-1|E1B848_BOVIN Computationally mapped isoform of UBA like domain containing 2 OS=Bos taurus OX=9913 GN=UBALD2 PE=3 SV=1 CANONICAL=E1B848-1" }, "locus": { "chromosome": "19", "start_pos": 55445758, "end_pos": 55444085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114313.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114313.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085242.1" } ] } }, { "isoform_ac": "E1B848-1", "url": "https://www.uniprot.org/uniprotkb/E1B848/entry", "sequence": { "sequence": "MPGSPTAPTSANGRGQAKRETVRARRPQDSNRTSAREPGPGRAERANQRRRLSAPERWDTRPRPALLFVVSAGSASRTTTLARRAARRPRVRRPRAAAASSSGGQPASRGRRARECAPAGAMSVNMDELRHQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIPNGHHHHQMQMCTPSNTPATPPNFPDALAMFSKLRASEGLQSSNSPMTAVACSPPANFSPFWASSPPSHQAAWIPPSSPTAHSFHHLHHPQPTWPPGAQQASTQQKAMAAMDGQR", "length": 288, "header": "tr|E1B848-1|E1B848_BOVIN Isoform 1 of UBA like domain containing 2 OS=Bos taurus OX=9913 GN=UBALD2 PE=3 SV=2 CANONICAL=E1B848-1" }, "locus": { "chromosome": "19", "start_pos": 55449270, "end_pos": 55444085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018321.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018321.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018321.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018321.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 193, "start_aa": "Thr", "end_pos": 193, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr193", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B848-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 288, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B848-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B848" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B848", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B848" }, { "id": "PF22566", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22566" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA-like", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 174, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 193 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 230, "end_pos": 232 }, { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBU9-1", "uniprot_ac": "E1BBU9", "uniprot_id": "E1BBU9_BOVIN", "mass": { "chemical_mass": 113066.0, "monoisotopic_mass": 113066.0 }, "refseq": { "ac": "NP_001192869", "name": "INO80 complex subunit D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192869" }, "gene_names": [ { "name": "INO80D", "type": "recommended", "evidence": [ { "id": "E1BBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ] }, { "name": "INO80D", "type": "synonym", "evidence": [ { "id": "NP_001192869", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192869" } ] } ], "protein_names": [ { "name": "INO80 complex subunit D", "type": "synonym", "evidence": [ { "id": "NP_001192869", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192869" }, { "id": "E1BBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBU9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INO80D", "url": "https://www.uniprot.org/uniprotkb/E1BBU9", "locus": { "chromosome": "2", "start_pos": 94357184, "end_pos": 94423403, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014407", "url": "https://www.ensembl.org/id/ENSBTAG00000014407" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014407", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014407", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527199", "url": "https://www.ncbi.nlm.nih.gov/gene/527199", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527199", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527199", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SWRPQNG", "url": "https://omabrowser.org/oma/group/SWRPQNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBU9", "url": "https://www.orthodb.org/?gene=E1BBU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16198:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16198:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13891", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13891", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192869", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T514", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T514", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T514-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T514-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T792", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T792", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T792-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T792-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBU9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPVHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPSAPSQQQPPQQHSHLSPLPTLKPPAPPQGVVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPAVDPPRTDRVLMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEELEDSEQASPYQVAWSIRETLRYERHTSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTLRKALLQAASREPECAGQLIQELQRAACSRASVSRTTLKEMEAAACSGTVKGEQCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVEASRIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQSDGVPVQELSDRGIGVFSTGTGASGIPSLSREVNTDLGELLNGRIVHDNFSSLELDESLLRSATLSNPPTPLAGQIQGQFSAPASVSLTSATLMSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPVMAQHLLPTPLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLVADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELLASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFTSPN", "length": 1026, "header": "tr|E1BBU9-1|E1BBU9_BOVIN Isoform 1 of INO80 complex subunit D OS=Bos taurus OX=9913 GN=INO80D PE=4 SV=3 CANONICAL=E1BBU9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STU0/entry", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPVHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPSAPSQQQPPQQHSHLSPLPTLKPPAPPQGVVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPAVDPPRTDRVLMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEELEDSEQASPYQVAWSIRETLRYERHTSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTLRKALLQAASREPECAGQLIQELQRAACSRASVSRTTLKEMEAAACSGTVKGEQCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVEASRIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQSDGVPVQELSDRGIGVFSTGTGASGIPSLSREVNTDLGELLNGRIVHDNFSSLELDESLLRSATLSNPPTPLAGQIQGQFSAPASVSLTSATLMSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPVMAQHLLPTPLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLVADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELLASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTAGGH", "length": 1012, "header": "tr|A0AAA9STU0-1|E1BBU9_BOVIN Computationally mapped isoform of INO80 complex subunit D OS=Bos taurus OX=9913 GN=INO80D PE=4 SV=1 CANONICAL=E1BBU9-1" }, "locus": { "chromosome": "2", "start_pos": 94404424, "end_pos": 94358188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114390.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114390.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087563.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087563.1" } ] } }, { "isoform_ac": "A0AAA9T514-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T514/entry", "sequence": { "sequence": "MKGPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPVHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPSAPSQQQPPQQHSHLSPLPTLKPPAPPQGVVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPAVDPPRTDRVLMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEELEDSEQASPYQVAWSIRETLRYERHTSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTLRKALLQAASREPECAGQLIQELQRAACSRASVSRTTLKEMEAAACSGTVKGEQCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVEASRIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQSDGVPVQELSDRGIGVFSTGTGASGIPSLSREVNTDLGELLNGRIVHDNFSSLELDESLLRSATLSNPPTPLAGQIQGQFSAPASVSLTSATLMSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPVMAQHLLPTPLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLVADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELLASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFTSPN", "length": 1008, "header": "tr|A0AAA9T514-1|E1BBU9_BOVIN Computationally mapped isoform of INO80 complex subunit D OS=Bos taurus OX=9913 GN=INO80D PE=4 SV=1 CANONICAL=E1BBU9-1" }, "locus": { "chromosome": "2", "start_pos": 94423204, "end_pos": 94363697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090821.1" } ] } }, { "isoform_ac": "A0AAA9T792-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T792/entry", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPVHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPSAPSQQQPPQQHSHLSPLPTLKPPAPPQGVVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPAVDPPRTDRVLMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEELEDSEQASPYQVAWSIRETLRYERHTSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTLRKALLQAASREPECAGQLIQELQRAACSRASVSRTTLKEMEAAACSGTVKGEQCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVEASRIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQSDGVPVQELSDRGIGVFSTGTGASGIPSLSREVNTDLGELLNGRIVHDNFSSLELDESLLRSATLSNPPTPLAGQIQGQFSAPASVSLTSATLMSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPVMAQHLLPTPLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLVADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELLASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTEFCSLMRQFKGFPGRKYSQSECFIADSYVAPRTFCPAENYICWRKVSVGIYIGQNIDFVSPPLNTLKTTEF", "length": 1079, "header": "tr|A0AAA9T792-1|E1BBU9_BOVIN Computationally mapped isoform of INO80 complex subunit D OS=Bos taurus OX=9913 GN=INO80D PE=4 SV=1 CANONICAL=E1BBU9-1" }, "locus": { "chromosome": "2", "start_pos": 94404424, "end_pos": 94359159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114587.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114587.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092610.1" } ] } }, { "isoform_ac": "E1BBU9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBU9/entry", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPVHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPSAPSQQQPPQQHSHLSPLPTLKPPAPPQGVVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPAVDPPRTDRVLMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEELEDSEQASPYQVAWSIRETLRYERHTSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTLRKALLQAASREPECAGQLIQELQRAACSRASVSRTTLKEMEAAACSGTVKGEQCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVEASRIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQSDGVPVQELSDRGIGVFSTGTGASGIPSLSREVNTDLGELLNGRIVHDNFSSLELDESLLRSATLSNPPTPLAGQIQGQFSAPASVSLTSATLMSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPVMAQHLLPTPLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLVADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELLASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFTSPN", "length": 1026, "header": "tr|E1BBU9-1|E1BBU9_BOVIN Isoform 1 of INO80 complex subunit D OS=Bos taurus OX=9913 GN=INO80D PE=4 SV=3 CANONICAL=E1BBU9-1" }, "locus": { "chromosome": "2", "start_pos": 94404424, "end_pos": 94363697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038286.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038286.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038101.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038101.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 937, "start_aa": "Thr", "end_pos": 937, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr937", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:527199", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527199", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5696394", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4INH3-1", "protein_name": "INO80 complex subunit Da", "gene_name": "ino80da", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKAEERRYCNSHLQVLGFIPKKERKKKQDGLEEVRSRAHVESVALNITVPSLALRDTNGLPASPPCSRLTPMPLLDSDLLDPFAFYEEDSDVEESLLQRPAQRSSSKRKASSTPVIGLRVTARDLEPDIEHFSAVTESCTLPSSPPPPPPSPPQPSQHTERPTYAPLGTVQTLLCKPAPPESASSVPLPPAGLQNQPVIWRPASPRPLSAHDCPQPRSVALRPAAFTAPPVCLLRLQHLVQLYANRQREHGDLFPHLGLDWSEDSADDEDTEELVPLLPQAWRLQERSPHQSSSSDKPLSRRARLAQLCSYLQERYKHLCRRDRAASRHSRYRYAFRKALLHAASKDPDCTAQLIQKLSRSSQTSSCSRSAAPHKYERTACTGSTKGQSCSNTALPFSRHCFQHILLNRSQQLFSSCTARFADGQQCSVPVFDITHQTPLCDEHAKKMDNFLRGDGHRRSQQQQQRRPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLLMPSLSLPTHHAHVRSPSTPELSADELPDDIANEMPDIPNDLELNQEDFSDVLPRLPDDLQDFDLFEGKNGELLPTTEEAEELVRALQAMGSYPDSLVCLSSIGELTQADGVDHRTMATVFSGSGVTPAGIGDLLNGRITSETFPNLDLLHAQTDHHFPSSPSPQPTQSSASSTSPSSGLTERTFPRAPKPDSSPPGSHYSSEHVPSPYRDHISPPHGASFQTDPPLLLEVPLSGAPGPPRTSWNNLPLSLTDPAQFGNLLTAETHLLSTALSTPPSTSHCSAILQPSSSSPSSREPKLQLPQFSAAFGHQLASHSGIPKDLQPSHSSTAPPTGFSITSATAATPPFPQSN", "length": 922 }, "evidence": [ { "id": "E1BBU9", "url": "https://omabrowser.org/oma/group/E1BBU9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A1D5P5H5-1", "protein_name": "INO80 complex subunit D", "gene_name": "INO80D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIEEVKVRHQMDTMALSLTMPTLALKMPNGLDGMSLSPPGARLPLHYLEAELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPLPAPLQQQPLQQQQHSHLPPSSALLKPTGLPQGIVCKSPQPPNTSLPMQGVAPTTHTIAQARQLSNKRPLPLLPPARAPVTDPPRTDRVLMKATAFSPHSSCMSRLQRLVKLCTRKQQLDTDLFPHLGLDWSEDSGEELEDSEQTSPYQVAWSVRESLGYERHESDDDNADDRSSRVTRLCTYFQQKYKHLCRLERAESRQKKCRHTLRKALLQAASREPERAGQLIQELRRATCARSSTSQARQRDAEPTTCSGTSKGEPCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLTMPASVSLPVEMPHIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQTDGVPVQELSDRGIGVFSTGAGAPGMQSLSREVNTDLGELLNGRIVHDNFSGLELDENLLRSATLSNPPTPLAGQIQGQFSAPANVGLTSATLISQSGLGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSFSGDNLAATFSAEMPMMAQHLLPTQLDVPLSGVVNPRTHWGSLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSHSETTQPAFATVTPNSSSVLPGLPQTSFSGMGPASAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFAVTGATATSTNNASAPFTTSN", "length": 1030 }, "evidence": [ { "id": "E1BBU9", "url": "https://omabrowser.org/oma/group/E1BBU9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZTM2-1", "protein_name": "INO80 complex subunit D", "gene_name": "Ino80d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPVDEVKVRHQMDAMAFSLTVPTLALKMPNGLDSMSLSPPGARVPLHYLETELEDPFAFNEEDDDLKKGVTVRKKLQSKLAQNRQRQRETEILKVRQEHFSTPPTPPQQHAHLSPLPTSLKPPAPPQGSVCKSPQPQSTSLPMQGVAPTTHSIAQTRQASHKRPLPLLPSSRAPVSDTPRTDRILMKATAFSPHFSCISRLQRLVKLCTQKHQLDADLFPHLGLDWSEESGEELEDSDQASPYQVAWSVRETLRQERHTSDDDDAESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQELRRAACSRDSLSQTKLKEVEPAACSGTVKGEQCTNQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVQASQIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFADVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLSQSDGVPVQGLSDRGMGVFSTGTDASGIQSLSREVNTDLGELLNGRIVHDSFSSLELDENLLHSATLSNPPTPLAGQIQGQFSAPASVGLTSATLLSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSAFSNLLGADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASPPFPTPN", "length": 1021 }, "evidence": [ { "id": "E1BBU9", "url": "https://omabrowser.org/oma/group/E1BBU9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SHE0-1", "protein_name": "INO80 complex subunit D", "gene_name": "INO80D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPLHYLETELEDPFAFNEEDDDLKKGATVKKKLQSKLAQNRQRQRETEILKVRQEHFSPPPAPSQQQPQPPQQHSHLSPLSTLKPPAPPQGLVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPVVDPPRTDQVLMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEEPEDSEQASPYQVAWSIRETLRYDRHMSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTFRKALLQAASREPECTGQLIQELQRAACSRTSLSRTKLKEVEPAACSGTVKGEQCTNKALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDSSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPASVSLPVEASQIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLTQSDGVPVQELSDRGIGVFATGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSNPPTPLAGQIQGQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELLASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFTSPN", "length": 1028 }, "evidence": [ { "id": "E1BBU9", "url": "https://omabrowser.org/oma/group/E1BBU9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q53TQ3-1", "protein_name": "INO80 complex subunit D", "gene_name": "INO80D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKNDPIDEVKVRHQMDTMAFSLTVPTLALKMPNGLDGMSLSPPGARVPLHYLETELEDPFAFNEEDDDLKKGATVRKKLQSKLAQNRQRQRETEILKVRQEHFSPPPAPSQQQPPQQHSHLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQGVAPTTHTIAQARQLSHKRPLPLLPSSRAPTVDPPRTDRILMKATAFSPHFSCISRLQRLVKLCTQKHQLDTDLFPHLGLDWSEESGEEPEDSEQASPYQVAWSIRETLRYQRHASDDDDAESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQELRRAACSRTSISRTKLREVEPAACSGTVKGEQCANKALPFTRHCFQHILLNHSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPASVSLPVEASHIRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLAQSDGVPVQELSDRGIGVFSTGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSNPPTPLAGQIQGQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPFPSPN", "length": 1027 }, "evidence": [ { "id": "E1BBU9", "url": "https://omabrowser.org/oma/group/E1BBU9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q66JY2-3", "protein_name": "INO80 complex subunit D", "gene_name": "Ino80d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYEGKHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKSEDRRYCNSHLQVLGFIPKKERKKKTDPVDEVKARHQMDAMAFSLTVPTLALKMPNGLDSMSLSPPGARVPLHYLDTELEDPFAFNEEDDDLKKGVTVRKKLQSKLAQNRQRQRETEILKVRQEHFSTPPTPPQQHTHLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQGVAPTTHSIAQIRQASHKRPLPLLPSSRAPISDAPRTDRILMKAAAFSPHLSCISRLQRLVKLCTQKRQLDADLFPHLGLDWSEESGEELEDADQASPYQVAWSIRETLRHERHTSDDDDMESRSSRVTQLCTYFQQKYKHLCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQELRRAACSRASLRQTKLKEVEPAACSGTVKGEQCTKQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMPTSVSLPVEASQMRSPSTPELSADELPDDIANEITDIPHDLELNQEDFADVLPRLPDDLQDFDFFEGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLSQSDGVPVQGLSDRGMGVFSTGTDASGIQSLSREVNTDLGELLNGRIVHDSFSSLELDENLLHSAPLSSPPTALAGQIQGQFSAPASAGLTSATLLSQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHITSPHTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSAFSNLLGADGHLLSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTATGATATSTNNASPPFPSPN", "length": 1021 }, "evidence": [ { "id": "E1BBU9", "url": "https://omabrowser.org/oma/group/E1BBU9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of DNA strand elongation", "id": "GO:0060382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060382", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "telomere maintenance", "id": "GO:0000723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "regulation of embryonic development", "id": "GO:0045995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045995", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" }, { "name": "positive regulation of telomere maintenance in response to DNA damage", "id": "GO:1904507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904507", "evidence": [ { "database": "UniProtKB", "id": "E1BBU9", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1017, "end_pos": 1019, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 724, "end_pos": 726, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBU9" }, { "id": "PF13891", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13891" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KANL2-like probable zinc-finger", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 78, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 937 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1017, "end_pos": 1019 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 473, "end_pos": 475 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 724, "end_pos": 726 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9C4-1", "uniprot_ac": "E1B9C4", "uniprot_id": "E1B9C4_BOVIN", "mass": { "chemical_mass": 59716.0, "monoisotopic_mass": 59716.0 }, "refseq": {}, "gene_names": [ { "name": "PDCD7", "type": "recommended", "evidence": [ { "id": "E1B9C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9C4" } ] } ], "protein_names": [ { "name": "Programmed cell death 7", "type": "synonym", "evidence": [ { "id": "E1B9C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9C4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9C4", "url": "https://www.uniprot.org/uniprotkb/E1B9C4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDCD7", "url": "https://www.uniprot.org/uniprotkb/E1B9C4", "locus": { "chromosome": "10", "start_pos": 12071022, "end_pos": 12082953, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039658", "url": "https://www.ensembl.org/id/ENSBTAG00000039658" } ] } } ], "crossref": [ { "id": "E1B9C4", "url": "https://alphafold.ebi.ac.uk/entry/E1B9C4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039658", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039658", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR031974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TSFWQRD", "url": "https://omabrowser.org/oma/group/TSFWQRD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9C4", "url": "https://www.orthodb.org/?gene=E1B9C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48190", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48190", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48190:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48190:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SU08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9C4", "url": "https://www.uniprot.org/uniprotkb/E1B9C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9C4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTPSLARRSLGRSVTLVPRVVCVTSSRKTLSPGTTQIPVTSQNPSVVAMALPPFFTPGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGSFPGASAPFLQPPLALQPRAPGEVSRGGGGGGGGGSFYPVPPPPLPPPPPQCRPFLGNDAGERPRPPPPGPGPPWSPRWPEAPPPSDALGDAALQRLRDRQWLEAVFGTPRRAGGSVPSRAPAGPSLGEVRARLRGALRLLRRLRDLGQALREAEADGAAWAQLHAQAQPLRAELAERLELLTQAAYVGEARRRLERVRRRRLRLRERVREREAEREAEAARAAEREQEIDRWRVQCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFEHHLQRLRKLIKKRSELYEAEERALQVMLEGEQEEERKRELEKKQRKEKEKFLLQKHEIESKLFGDPDEFPLAHLLQPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGSSIPQGWVLPPLPSNDIWATAVKLH", "length": 536, "header": "tr|E1B9C4-1|E1B9C4_BOVIN Isoform 1 of Programmed cell death 7 OS=Bos taurus OX=9913 GN=PDCD7 PE=4 SV=2 CANONICAL=E1B9C4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU08/entry", "sequence": { "sequence": "MALPPFFTPGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGSFPGASAPFLQPPLALQPRAPGEVSRGGGGGGGGGSFYPVPPPPLPPPPPQCRPFLGNDAGERPRPPPPGPGPPWSPRWPEAPPPSDALGDAALQRLRDRQWLEAVFGTPRRAGGSVPSRAPAGPSLGEVRARLRGALRLLRRLRDLGQALREAEAAYVGEARRRLERVRRRRLRLRERVREREAEREAEAARAAEREQEIDRWRVQCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFEHHLQRLRKLIKKRSELYEAEERALQVMLEGEQEEERKRELEKKQRKEKEKFLLQKHEIESKLFGDPDEFPLAHLLQPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGSSIPQGWVLPPLPSNDIWATAVKLH", "length": 458, "header": "tr|A0AAA9SU08-1|E1B9C4_BOVIN Computationally mapped isoform of Programmed cell death 7 OS=Bos taurus OX=9913 GN=PDCD7 PE=4 SV=1 CANONICAL=E1B9C4-1" }, "locus": { "chromosome": "10", "start_pos": 12082654, "end_pos": 12072058, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109830.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109830.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086600.1" } ] } }, { "isoform_ac": "E1B9C4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9C4/entry", "sequence": { "sequence": "MKTPSLARRSLGRSVTLVPRVVCVTSSRKTLSPGTTQIPVTSQNPSVVAMALPPFFTPGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGSFPGASAPFLQPPLALQPRAPGEVSRGGGGGGGGGSFYPVPPPPLPPPPPQCRPFLGNDAGERPRPPPPGPGPPWSPRWPEAPPPSDALGDAALQRLRDRQWLEAVFGTPRRAGGSVPSRAPAGPSLGEVRARLRGALRLLRRLRDLGQALREAEADGAAWAQLHAQAQPLRAELAERLELLTQAAYVGEARRRLERVRRRRLRLRERVREREAEREAEAARAAEREQEIDRWRVQCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFEHHLQRLRKLIKKRSELYEAEERALQVMLEGEQEEERKRELEKKQRKEKEKFLLQKHEIESKLFGDPDEFPLAHLLQPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGSSIPQGWVLPPLPSNDIWATAVKLH", "length": 536, "header": "tr|E1B9C4-1|E1B9C4_BOVIN Isoform 1 of Programmed cell death 7 OS=Bos taurus OX=9913 GN=PDCD7 PE=4 SV=2 CANONICAL=E1B9C4-1" }, "locus": { "chromosome": "10", "start_pos": 12082801, "end_pos": 12072058, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054198.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054198.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049812.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049812.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z1W3-1", "protein_name": "Programmed cell death 7", "gene_name": "PDCD7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQPPPPFPGRFPPPPFRAFPPQAPGPFPPPPAPFSVPAARPALPPFLLPPSSEPGPFFRGPAAPPLFPPWPSAERPPPPRDPEDEDAAQRQRDERWLAEFLARRGPPAAPPLPPGGASPELGRQLAVRALGAVSRLAALCRALRRREAEGCEEGWERERAEAEALLEGLRETVRPLREPGYLRELGRKAEKARKRRERLQRRKREARAAKEEEAARAAEREAEIDRWRAKCIQEVEEKNRERELKAAADSVLSEVRKKQADTKRMVDILGSLEKLRKLRKEAAARKGVCPPPSADEAFENQVESLRTLLKNRTELYEAEERALRVMLEGEQEEERKRELEKKQKKEREKLLQQKREIDSKLFGDPDEFPLAHLLQPFREYYLQAELSVAALIQIRHEWDQYLVPADHPEGSCIPPGWVLPTLPTNDTWATAVR", "length": 434 }, "evidence": [ { "id": "E1B9C4", "url": "https://omabrowser.org/oma/group/E1B9C4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ACM6-1", "protein_name": "Programmed cell death 7", "gene_name": "Pdcd7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALPPFFAQSRQGPPPPQPPPSAPFSCPPPPLPSPVFPPPLPQRPGPFPGASAPFLQPPIALQPRASAEASRGGGGSGGGGAFFPVPPPPLPPPPQCRPFPGPDVVERPRPPPPGPGPPWSPRWAEAPPPPDVLGDAALQRLRDRQWLEAVFGNPRRPVGPRTPRTPAGPSLGEVRARLRAALRLVRRLRSLGQSLREAEADGAAWVSLHAQAAPLRAELAERLQPLAQAAYMGEARRRLERVRRRRLRLRERARERETEREAEAAQATEREQEIDRWRMKCVQEVEEKKREQELKAAADGVLAEVRKKQSDTKRMVDILRALEKLRKLRKEAAARKGVCPPAAADETFEHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERRRELEKKQRKEKEKLLLQKREIESKLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNSIPQGWVLPPLPSNDIWATAVQLH", "length": 486 }, "evidence": [ { "id": "E1B9C4", "url": "https://omabrowser.org/oma/group/E1B9C4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N8D1-1", "protein_name": "Programmed cell death protein 7", "gene_name": "PDCD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESKLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNFVPQGWVLPPLPSNDIWATAVKLH", "length": 485 }, "evidence": [ { "id": "E1B9C4", "url": "https://omabrowser.org/oma/group/E1B9C4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VYD3-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 59 kDa protein", "gene_name": "SNRNP59", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNPANFQPPNPPFHWAPMLPPDPPRCGMFWNTKNITDQLKQLQDTLNLAKSMEKELEALKMIKDAKGSVENAVQDSGVEYLEARKMDLGQQEMLSVDAANSLMSTLRAQLEPFRFVVDENSPWEEKSAAVRLTCKMKKSIRNKLWKKRKRRCAAEMRAKEPERFEQADREADEWREKEMAKDMANRKVDEMKAIEKIKAKRERKRLEPELELALIVEEMQELRSLRIEKLKKQGHFLPEEDDKFFESVRAAVEQEENQAQSLINTETEEHVIASEENTTLTTSNKTNNDTDKDSNTNAASCERTMKAPDNGCDNISNLPVEVYHYYYGSNIDMGRLIEIRREWDAYLSAGGSRIPGHWVQPSPPANEIWASCLVNTPKRDLS", "length": 382 }, "evidence": [ { "id": "E1B9C4", "url": "https://omabrowser.org/oma/group/E1B9C4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "E1B9C4", "url": "https://www.uniprot.org/uniprotkb/E1B9C4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9C4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 536, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9C4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9C4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAA4-1", "uniprot_ac": "E1BAA4", "uniprot_id": "E1BAA4_BOVIN", "mass": { "chemical_mass": 39252.0, "monoisotopic_mass": 39252.0 }, "refseq": {}, "gene_names": [ { "name": "NOXO1", "type": "recommended", "evidence": [ { "id": "E1BAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ] } ], "protein_names": [ { "name": "NADPH oxidase organizer 1", "type": "recommended", "evidence": [ { "id": "E1BAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4#function" }, { "database": "UniProtKB", "id": "ARBA00059981", "url": "https://www.uniprot.org/uniprotkb/ARBA00059981#function" }, { "database": "UniProtKB", "id": "A0AAA9SUR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUR6#function" }, { "database": "UniProtKB", "id": "A0AAA9TEH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOXO1", "url": "https://www.uniprot.org/uniprotkb/E1BAA4", "locus": { "chromosome": "25", "start_pos": 1534526, "end_pos": 1540105, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020369", "url": "https://www.ensembl.org/id/ENSBTAG00000020369" } ] } } ], "crossref": [ { "id": "E1BAA4", "url": "https://alphafold.ebi.ac.uk/entry/E1BAA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020369", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020369", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516233", "url": "https://www.ncbi.nlm.nih.gov/gene/516233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAA4", "url": "https://www.orthodb.org/?gene=E1BAA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15706", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15706:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SUR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGARHPVCVSGAALVQTERFQQMFTFSVCWSDDTDSFIRRSWEDFRRLHKTLKETFPVEAGLLRRSDRVLPKLPADAPWLVHRSRTGRGLARLQLLEAYLRALLAAGERVSRSLELTGFFTPQPLDLEPMLPPGSLVILPTPQEPSPGPSGSPAVHTLEAQSLHCLQTFSTQDTRGQPFHAQAQEALDVLLRHPSGWWLVTNEDQQTAWFPAPYLEEAAPHQGQDGGQLLGISGPQFCAVRAYESSRADELSVPTGARVHVLEASDRGWWLCRFQGRTGLLPAVMLQRDGLGTLLSGPWLHRGADGAEGREGKAHSSPRSPQAAMLPPPVPARPPLSVIQSRCCTITRKALQQGAP", "length": 357, "header": "tr|E1BAA4-1|E1BAA4_BOVIN Isoform 1 of NADPH oxidase organizer 1 OS=Bos taurus OX=9913 GN=NOXO1 PE=4 SV=4 CANONICAL=E1BAA4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUR6/entry", "sequence": { "sequence": "MRNQLRRIGRANGGGRRSLTSCLGRKIPLESVFHGSKRGPQALWGEHGAVVVVQMFTFSVCWSDDTDSFIRRSWEDFRRLHKTLKETFPVEAGLLRRSDRVLPKLPADAPWLVHRSRTGRGLARLQLLEAYLRALLAAGERVSRSLELTGFFTPQPLDLEPMLPPGSLVILPTPQEPSPGPSGSPAVHTLEAQSLHCLQTFSTQDTRGQPFHAQAQEALDVLLRHPSGWWLVTNEDQQTAWFPAPYLEEAAPHQGQDGGQLLGISGPQFCAVRAYESSRADELSVPTGARVHVLEASDRGWWLCRFQGRTGLLPAVMLQRDGLGTLLSGPWLHRGADGAEGREGKAHSSPRSPQAAMLPPPVPARPPLSVIQSRCCTITRKALQQGAP", "length": 388, "header": "tr|A0AAA9SUR6-1|E1BAA4_BOVIN Computationally mapped isoform of NADPH oxidase organizer 1 OS=Bos taurus OX=9913 GN=NOXO1 PE=4 SV=1 CANONICAL=E1BAA4-1" }, "locus": { "chromosome": "25", "start_pos": 1538849, "end_pos": 1535123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132906.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132906.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089090.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089090.1" } ] } }, { "isoform_ac": "A0AAA9TEH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH6/entry", "sequence": { "sequence": "MPPAQCLPGQRGLHTGIQAGLQASARAAARARPQEPGARAAGAELGPGAGPGAGAGLAARVRAPGDAGVRAGDAPEARAAIPLESVFHGSKRGPQALWGEHGAVVVVQMFTFSVCWSDDTDSFIRRSWEDFRRLHKTLKETFPVEAGLLRRSDRVLPKLPADAPWLVHRSRTGRGLARLQLLEAYLRALLAAGERVSRSLELTGFFTPQPLDLEPMLPPGSLVILPTPQEPSPGPSGSPAVHTLEAQSLHCLQTFSTQDTRGQPFHAQAQEALDVLLRHPSGWWLVTNEDQQTAWFPAPYLEEAAPHQGQDGGQLLGISGPQFCAVRAYESSRADELSVPTGARVHVLEASDRGWWLCRFQGRTGLLPAVMLQRDGLGTLLSGPWLHRGADGAEGREGKAHSSPRSPQAAMLPPPVPARPPLSVIQSRCCTITRKALQQGAP", "length": 442, "header": "tr|A0AAA9TEH6-1|E1BAA4_BOVIN Computationally mapped isoform of NADPH oxidase organizer 1 OS=Bos taurus OX=9913 GN=NOXO1 PE=4 SV=1 CANONICAL=E1BAA4-1" }, "locus": { "chromosome": "25", "start_pos": 1539906, "end_pos": 1535123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118986.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118986.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095197.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095197.1" } ] } }, { "isoform_ac": "E1BAA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA4/entry", "sequence": { "sequence": "MEGARHPVCVSGAALVQTERFQQMFTFSVCWSDDTDSFIRRSWEDFRRLHKTLKETFPVEAGLLRRSDRVLPKLPADAPWLVHRSRTGRGLARLQLLEAYLRALLAAGERVSRSLELTGFFTPQPLDLEPMLPPGSLVILPTPQEPSPGPSGSPAVHTLEAQSLHCLQTFSTQDTRGQPFHAQAQEALDVLLRHPSGWWLVTNEDQQTAWFPAPYLEEAAPHQGQDGGQLLGISGPQFCAVRAYESSRADELSVPTGARVHVLEASDRGWWLCRFQGRTGLLPAVMLQRDGLGTLLSGPWLHRGADGAEGREGKAHSSPRSPQAAMLPPPVPARPPLSVIQSRCCTITRKALQQGAP", "length": 357, "header": "tr|E1BAA4-1|E1BAA4_BOVIN Isoform 1 of NADPH oxidase organizer 1 OS=Bos taurus OX=9913 GN=NOXO1 PE=4 SV=4 CANONICAL=E1BAA4-1" }, "locus": { "chromosome": "25", "start_pos": 1537093, "end_pos": 1535123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047285.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047285.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044503.5", "url": "https://www.ensembl.org/id/ENSBTAP00000044503.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 142, "start_aa": "Thr", "end_pos": 142, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr142", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" }, { "name": "NADPH oxidase complex", "id": "GO:0043020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" }, { "name": "superoxide-generating NADPH oxidase activator activity", "id": "GO:0016176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016176", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "extracellular matrix disassembly", "id": "GO:0022617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022617", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" }, { "name": "superoxide anion generation", "id": "GO:0042554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554", "evidence": [ { "database": "UniProtKB", "id": "E1BAA4", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAA4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 357, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAA4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAA4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 128, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA4" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 221, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 142 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A1A4P9-1", "uniprot_ac": "A1A4P9", "uniprot_id": "CC167_BOVIN", "mass": { "chemical_mass": 11246.0, "monoisotopic_mass": 11246.0 }, "refseq": { "ac": "NP_001073705", "name": "coiled-coil domain-containing protein 167", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705" }, "gene_names": [ { "name": "CCDC167", "type": "recommended", "evidence": [ { "id": "A1A4P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4P9" } ] }, { "name": "C23H6orf129", "type": "synonym", "evidence": [ { "id": "NP_001073705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705" } ] }, { "name": "C6orf129", "type": "synonym", "evidence": [ { "id": "NP_001073705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705" } ] }, { "name": "CCDC167", "type": "synonym", "evidence": [ { "id": "NP_001073705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 167", "type": "recommended", "evidence": [ { "id": "A1A4P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4P9/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 167", "type": "synonym", "evidence": [ { "id": "NP_001073705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705" } ] }, { "name": "transmembrane and coiled-coil domain-containing protein C6orf129 homolog", "type": "synonym", "evidence": [ { "id": "NP_001073705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A1A4P9", "url": "https://www.uniprot.org/uniprotkb/A1A4P9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC167", "url": "https://www.uniprot.org/uniprotkb/A1A4P9", "locus": { "chromosome": "23", "start_pos": 11372647, "end_pos": 11389032, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012069", "url": "https://www.ensembl.org/id/ENSBTAG00000012069" } ] } } ], "crossref": [ { "id": "A1A4P9", "url": "https://alphafold.ebi.ac.uk/entry/A1A4P9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012069", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012069", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507353", "url": "https://www.ncbi.nlm.nih.gov/gene/507353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507353", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MAIMNER", "url": "https://omabrowser.org/oma/group/MAIMNER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A1A4P9", "url": "https://www.orthodb.org/?gene=A1A4P9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31759", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31759", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31759:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31759:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073705", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YWZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4P9", "url": "https://www.uniprot.org/uniprotkb/A1A4P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4P9-1", "url": "https://www.uniprot.org/uniprotkb/A1A4P9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTKKKRENLGVALEIDGLEKKLSQCRRDLEVVNSRLCGVELSSEARRSLEKEKSSLMNKASNYEKELKLLRQENRKNMLLSVAIFLLLTVIYAYWAL", "length": 97, "header": "sp|A1A4P9-1|CC167_BOVIN Isoform 1 of Coiled-coil domain-containing protein 167 OS=Bos taurus OX=9913 GN=CCDC167 PE=4 SV=1 CANONICAL=A1A4P9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YWZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWZ7/entry", "sequence": { "sequence": "ILSHWTTREVPDIDGLEKKLSQCRRDLEVVNSRLCGVELSSEARRSLEKEKSSLMNKASNYEKELKLLRQENRKNMLLSVAIFLLLTVIYAYWAL", "length": 95, "header": "tr|A0AAF6YWZ7-1|CC167_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 167 OS=Bos taurus OX=9913 GN=CCDC167 PE=4 SV=1 CANONICAL=A1A4P9-1" }, "locus": {} }, { "isoform_ac": "A1A4P9-1", "url": "https://www.uniprot.org/uniprotkb/A1A4P9/entry#A1A4P9-1", "sequence": { "sequence": "MTKKKRENLGVALEIDGLEKKLSQCRRDLEVVNSRLCGVELSSEARRSLEKEKSSLMNKASNYEKELKLLRQENRKNMLLSVAIFLLLTVIYAYWAL", "length": 97, "header": "sp|A1A4P9-1|CC167_BOVIN Isoform 1 of Coiled-coil domain-containing protein 167 OS=Bos taurus OX=9913 GN=CCDC167 PE=4 SV=1 CANONICAL=A1A4P9-1" }, "locus": { "chromosome": "23", "start_pos": 11388973, "end_pos": 11373707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016009.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016009.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016009.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016009.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507353", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507353", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AUD4-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "CCDC167", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTKKKRENLGVALEIDGLEEKLSQCRRELEAVNSRLYGAELSPEARRSLEKEKSSLMSKASNYEKELKLLRQENRKNMLLSVVIFILLTFLYAYWTT", "length": 97 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7IER4-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "Ccdc167", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTKKKRENLGVAQEIDGLEEKLSQCRKDLEAVTSQLYRTELSPEDRRSLEKEKTTLMSKASKYEKELKLLRQENRKNMLLSVAIFILLALLYAHWTM", "length": 97 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZL03-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "CCDC167", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRRLLGEGFSSLPPPLRLALISSMRVRRRKPHYLTLLDVNIDELEEKLSLCRQSMEEVDLKLRGEKLSHEGRKSLERERNLLMTKADNYEKELSVLRKENRKNAALAVAMVLLIALIYTCWTM", "length": 123 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M027-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "Ccdc167", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKKKRENLGVAREIDGLEEKLSQCRKDLEAVTSQLHRAELSPEDRRSLEKEKNALMNKASKYEKELKLLRQENQKNMLLSVAIFIVFALLYAYWTMHESSCPPCPPCPGAQAHRWLKCCSRTSLPFSTRTSRMWIALIFRWAFPYNDKHAVRWAGRPALPALCALLVSKCLCLSRGKVASGLEQRLD", "length": 188 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5RHZ2-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "ccdc167", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTRTRTVKKEKISVASEIDRVEERKLQCKNSLERAEFRKRKQQLSDDDRLALEDEMTILNERVEKYEKDLQVLRGENRRNMMLSVALLAISALFYYTFIY", "length": 100 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D162-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "Ccdc167", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKKKRENLGVAQEIDGLEEKLSRCRKDLEAVTSQLYRAELSPEDRRSLEKEKHTLMNKASKYEKELKLLRHENRKNTLLSVAIFTVFALLYAYWTM", "length": 97 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0B6-1", "protein_name": "Coiled-coil domain-containing protein 167", "gene_name": "CCDC167", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTKKKRENLGVALEIDGLEEKLSQCRRDLEAVNSRLHSRELSPEARRSLEKEKNSLMNKASNYEKELKFLRQENRKNMLLSVAIFILLTLVYAYWTM", "length": 97 }, "evidence": [ { "id": "A1A4P9", "url": "https://omabrowser.org/oma/group/A1A4P9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A1A4P9", "url": "https://www.uniprot.org/uniprotkb/A1A4P9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A1A4P9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 97, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A1A4P9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A1A4P9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA00-1", "uniprot_ac": "E1BA00", "uniprot_id": "E1BA00_BOVIN", "mass": { "chemical_mass": 16187.0, "monoisotopic_mass": 16187.0 }, "refseq": { "ac": "XP_005225772", "name": "proline-rich acidic protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225772" }, "gene_names": [ { "name": "PRAP1", "type": "recommended", "evidence": [ { "id": "E1BA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA00" } ] }, { "name": "PRAP1", "type": "synonym", "evidence": [ { "id": "XP_005225772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225772" } ] } ], "protein_names": [ { "name": "Proline rich acidic protein 1", "type": "synonym", "evidence": [ { "id": "E1BA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA00/entry#names_and_taxonomy" } ] }, { "name": "proline-rich acidic protein 1", "type": "synonym", "evidence": [ { "id": "XP_005225772", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225772" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA00", "url": "https://www.uniprot.org/uniprotkb/E1BA00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRAP1", "url": "https://www.uniprot.org/uniprotkb/E1BA00", "locus": { "chromosome": "26", "start_pos": 25654877, "end_pos": 25658447, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013717", "url": "https://www.ensembl.org/id/ENSBTAG00000013717" } ] } } ], "crossref": [ { "id": "E1BA00", "url": "https://alphafold.ebi.ac.uk/entry/E1BA00", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013717", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512786", "url": "https://www.ncbi.nlm.nih.gov/gene/512786", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512786", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512786", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVETEDI", "url": "https://omabrowser.org/oma/group/WVETEDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BA00", "url": "https://www.orthodb.org/?gene=E1BA00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37861:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37861:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15314", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15314", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225772", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225772", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA00", "url": "https://www.uniprot.org/uniprotkb/E1BA00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA00-1", "url": "https://www.uniprot.org/uniprotkb/E1BA00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRLLLLTSLVAVLLLEAGSARIPQVRVQTKGKVGAEQDTEVWDARAVESPEKDNQLIWLLMAPKLMTTSKEQKGAKAPAETEDALGHVLGPREGPEPDWDSLFHDGPEEVLEEARPWARVLPPRQVLHGPEEDRDHIYHPREP", "length": 144, "header": "tr|E1BA00-1|E1BA00_BOVIN Isoform 1 of Proline rich acidic protein 1 OS=Bos taurus OX=9913 GN=PRAP1 PE=4 SV=1 CANONICAL=E1BA00-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH6/entry", "sequence": { "sequence": "SSPGSPEAPAGHPTPSGPSSSQSSPALLFCGLFQEPQLGHEVGPSVTWGPSGVQSLCLGLGAQIRPAPCSPGQVPALCPHDVPGNPYLDVLSHPEGRRSPWGWKRSWGIGQEALGPSPNHGPQALPRSGTLPAHGQLSCARLLLLTSLVAVLLLEAGSARIPQVRVQTKGKVGAEQDTEVWDARAVESPEKDNQLIWLLMAPKLMTTSKEQKGAKAPAETEDALGHVLGPREGPEPDWDSLFHDGPEEVLEEARPWARVLPPRQVLHGPEEDRDHIYHPREP", "length": 282, "header": "tr|A0AAA9SVH6-1|E1BA00_BOVIN Computationally mapped isoform of Proline rich acidic protein 1 OS=Bos taurus OX=9913 GN=PRAP1 PE=4 SV=1 CANONICAL=E1BA00-1" }, "locus": { "chromosome": "26", "start_pos": 25657845, "end_pos": 25654919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128741.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128741.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090474.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090474.1" } ] } }, { "isoform_ac": "E1BA00-1", "url": "https://www.uniprot.org/uniprotkb/E1BA00/entry", "sequence": { "sequence": "MRRLLLLTSLVAVLLLEAGSARIPQVRVQTKGKVGAEQDTEVWDARAVESPEKDNQLIWLLMAPKLMTTSKEQKGAKAPAETEDALGHVLGPREGPEPDWDSLFHDGPEEVLEEARPWARVLPPRQVLHGPEEDRDHIYHPREP", "length": 144, "header": "tr|E1BA00-1|E1BA00_BOVIN Isoform 1 of Proline rich acidic protein 1 OS=Bos taurus OX=9913 GN=PRAP1 PE=4 SV=1 CANONICAL=E1BA00-1" }, "locus": { "chromosome": "26", "start_pos": 25658355, "end_pos": 25654919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018224.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018224.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018224.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018224.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512786", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512786", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SAB9-1", "protein_name": "Proline rich acidic protein 1", "gene_name": "PRAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRLLLVTSLVAVLLLEAGSAPTPQALVKIKGKAGAEQDMEEAWSSGLVDPPGKDKQWEQLLQVASQEQQEGAKALAGNKDTLDRVPSPKWGPEPDRDHLYHSWPQEAQEEARPWARALPPRQVLQGPEEDRDHIYHPRGDSWEP", "length": 145 }, "evidence": [ { "id": "E1BA00", "url": "https://omabrowser.org/oma/group/E1BA00/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80XD8-1", "protein_name": "Proline-rich acidic protein 1", "gene_name": "Prap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRFLLATCLVAALLWEAGAAPAHQVPVKTKGKHVFPEQETEKVWDTRALEPLEKDNQLGPLLPEPKQKPAAAEEKRPDAMTWVETEDILSHLRSPLQGPELDLDSIDHPMSDDVQDEEVPQSRPILYRQVLQGPEEDLDHLAHSMEDS", "length": 149 }, "evidence": [ { "id": "E1BA00", "url": "https://omabrowser.org/oma/group/E1BA00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96NZ9-1", "protein_name": "Proline-rich acidic protein 1", "gene_name": "PRAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ", "length": 151 }, "evidence": [ { "id": "E1BA00", "url": "https://omabrowser.org/oma/group/E1BA00/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ES75-1", "protein_name": "Proline-rich acidic protein 1", "gene_name": "Prap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKRFLLATCLVAVLLWEAGAIPAHQVPVKTKGKHVFPEQETEKAWGTRAMEPLEKDDQLRALLPVPKQKLAATEEKHSDTMTWVETKDILSRFRNPLQGPELDLDSIYHPMSEDVQNEEVPQSRPILYRQVLHGPEEDLDHISHSLEDSGEP", "length": 152 }, "evidence": [ { "id": "E1BA00", "url": "https://omabrowser.org/oma/group/E1BA00/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8W2-1", "uniprot_ac": "E1B8W2", "uniprot_id": "E1B8W2_BOVIN", "mass": { "chemical_mass": 21041.0, "monoisotopic_mass": 21041.0 }, "refseq": { "ac": "XP_002687892", "name": "killer cell lectin-like receptor subfamily G member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687892" }, "gene_names": [ { "name": "KLRG1", "type": "recommended", "evidence": [ { "id": "E1B8W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8W2" } ] }, { "name": "KLRG1", "type": "synonym", "evidence": [ { "id": "XP_002687892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687892" } ] } ], "protein_names": [ { "name": "Killer cell lectin like receptor G1", "type": "synonym", "evidence": [ { "id": "E1B8W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8W2/entry#names_and_taxonomy" } ] }, { "name": "killer cell lectin-like receptor subfamily G member 1", "type": "synonym", "evidence": [ { "id": "XP_002687892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687892" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8W2", "url": "https://www.uniprot.org/uniprotkb/E1B8W2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLRG1", "url": "https://www.uniprot.org/uniprotkb/E1B8W2", "locus": { "chromosome": "5", "start_pos": 100946724, "end_pos": 100964344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013640", "url": "https://www.ensembl.org/id/ENSBTAG00000013640" } ] } } ], "crossref": [ { "id": "E1B8W2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8W2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013640", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013640", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100295672", "url": "https://www.ncbi.nlm.nih.gov/gene/100295672", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100295672", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295672", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCPDFWM", "url": "https://omabrowser.org/oma/group/SCPDFWM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8W2", "url": "https://www.orthodb.org/?gene=E1B8W2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47648", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47648", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47648:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47648:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687892", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687892", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8W2", "url": "https://www.uniprot.org/uniprotkb/E1B8W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8W2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8W2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDNVTYSIIKSSAARQALKDDRQQQEASSSRSPRSYHVAIALGLLSTILASMLLLQWILYRGSKCAGCPHCPDHWMGYGDHCYYFSVEKKSWNSSLEFCLAKDAHLLMFKDSKEMIELQNLLSQEFYWIGLRNSSGWRWEDGSALNISRIASNSLVQNCGTISKGGLLASSCEVDFPWVCKKVRR", "length": 186, "header": "tr|E1B8W2-1|E1B8W2_BOVIN Isoform 1 of Killer cell lectin like receptor G1 OS=Bos taurus OX=9913 GN=KLRG1 PE=4 SV=2 CANONICAL=E1B8W2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY1/entry", "sequence": { "sequence": "MTDNVTYSIIKSSAARQALKDDRQQQEASSSRSPRSYHVAIALGLLSTILASMLLLQWILYRGSKCAGCPHCPDHWMGYGDHCYYFSVEKKSWNSSLEFCLAKDAHLLMFKDSKEMEQVSREPHLLGSPFVAPWVEPTSFLGIAGSKNVPRACGQIELQNLLSQEFYWIGLRNSSGWRWEDGSALNISRIASNSLVQNCGTISKGGLLASSCEVDFPWVCKKVRR", "length": 225, "header": "tr|A0AAA9SWY1-1|E1B8W2_BOVIN Computationally mapped isoform of Killer cell lectin like receptor G1 OS=Bos taurus OX=9913 GN=KLRG1 PE=4 SV=1 CANONICAL=E1B8W2-1" }, "locus": { "chromosome": "5", "start_pos": 100964236, "end_pos": 100947728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129602.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129602.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087759.1" } ] } }, { "isoform_ac": "A0AAA9TJJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ0/entry", "sequence": { "sequence": "MTDNVTYSIIKSSAARQALKDDRQQQEASSSRSPRSYHVAIALGLLSTILASMLLLQWILYRGSKCAGCPHCPDHWMGYGDHCYYFSVEKKSWNSSLEFCLAKDAHLLMFKDSKEMIELQNLLSQEFYWIGLRNSSGWRWEDGSALNISRIASNSLVQNCGTISKGGLLASSCEVDFPWVCKKCLFAGKT", "length": 190, "header": "tr|A0AAA9TJJ0-1|E1B8W2_BOVIN Computationally mapped isoform of Killer cell lectin like receptor G1 OS=Bos taurus OX=9913 GN=KLRG1 PE=4 SV=1 CANONICAL=E1B8W2-1" }, "locus": { "chromosome": "5", "start_pos": 100964236, "end_pos": 100947275, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103471.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103471.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098508.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098508.1" } ] } }, { "isoform_ac": "E1B8W2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8W2/entry", "sequence": { "sequence": "MTDNVTYSIIKSSAARQALKDDRQQQEASSSRSPRSYHVAIALGLLSTILASMLLLQWILYRGSKCAGCPHCPDHWMGYGDHCYYFSVEKKSWNSSLEFCLAKDAHLLMFKDSKEMIELQNLLSQEFYWIGLRNSSGWRWEDGSALNISRIASNSLVQNCGTISKGGLLASSCEVDFPWVCKKVRR", "length": 186, "header": "tr|E1B8W2-1|E1B8W2_BOVIN Isoform 1 of Killer cell lectin like receptor G1 OS=Bos taurus OX=9913 GN=KLRG1 PE=4 SV=2 CANONICAL=E1B8W2-1" }, "locus": { "chromosome": "5", "start_pos": 100964236, "end_pos": 100947728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018130.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018130.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018130.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018130.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100295672", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295672", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H7R7-1", "protein_name": "Killer cell lectin-like receptor subfamily G member 1", "gene_name": "Klrg1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADSDIYCTLELPATPQVQEDSRSKLRALFRRLPLSCLVTVALGLLTVILVGLLMCQRIPCCGSKDSVCAHCPSCPNLWMRNGSHCYYFSTEKKDWNSSLEFCADKGSHLLMFLDDEEVIPFQKYLDNDFYWIGLRKTDGWRWEGGPILSLRIVSNSLIQTCGTIHKDGLQASSCEVPLRWICQKTTN", "length": 188 }, "evidence": [ { "id": "E1B8W2", "url": "https://omabrowser.org/oma/group/E1B8W2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O88713-1", "protein_name": "Killer cell lectin-like receptor subfamily G member 1", "gene_name": "Klrg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSSIYSTLELPEAPQVQDESRWKLKAVLHRPHLSRFAMVALGLLTVILMSLLMYQRILCCGSKDSTCSHCPSCPILWTRNGSHCYYFSMEKKDWNSSLKFCADKGSHLLTFPDNQGVKLFGEYLGQDFYWIGLRNIDGWRWEGGPALSLRILTNSLIQRCGAIHRNGLQASSCEVALQWICKKVLY", "length": 188 }, "evidence": [ { "id": "E1B8W2", "url": "https://omabrowser.org/oma/group/E1B8W2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q64335-1", "protein_name": "Killer cell lectin-like receptor subfamily G member 1", "gene_name": "Klrg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADNSIYSTLELPAAPRVQDDSRWKVKAVLHRPCVSYLVMVALGLLTVILMSLLLYQRTLCCGSKGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSSLKFCADKGSHLLTFPDNQGVNLFQEYVGEDFYWIGLRDIDGWRWEDGPALSLSILSNSVVQKCGTIHRCGLHASSCEVALQWICEKVLP", "length": 188 }, "evidence": [ { "id": "E1B8W2", "url": "https://omabrowser.org/oma/group/E1B8W2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96E93-1", "protein_name": "Killer cell lectin-like receptor subfamily G member 1", "gene_name": "KLRG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALGLLTAVLLSVLLYQWILCQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMSLLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPLHWVCKKCPFADQALF", "length": 195 }, "evidence": [ { "id": "E1B8W2", "url": "https://omabrowser.org/oma/group/E1B8W2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B8W2", "url": "https://www.uniprot.org/uniprotkb/E1B8W2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1B8W2", "url": "https://www.uniprot.org/uniprotkb/E1B8W2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8W2" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 79, "end_pos": 182, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 147, "end_pos": 149 }, { "start_pos": 4, "end_pos": 6 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7M5-1", "uniprot_ac": "E1B7M5", "uniprot_id": "E1B7M5_BOVIN", "mass": { "chemical_mass": 61783.0, "monoisotopic_mass": 61783.0 }, "refseq": { "ac": "NP_001192368", "name": "spermine oxidase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" }, "gene_names": [ { "name": "SMOX", "type": "recommended", "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ] }, { "name": "SMOX", "type": "synonym", "evidence": [ { "id": "NP_001192368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" } ] } ], "protein_names": [ { "name": "Spermine oxidase", "type": "recommended", "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5/entry#names_and_taxonomy" } ] }, { "name": "1.5.3.16", "type": "synonym", "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5/entry#names_and_taxonomy" } ] }, { "name": "Polyamine oxidase 1", "type": "synonym", "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5/entry#names_and_taxonomy" } ] }, { "name": "spermine oxidase", "type": "synonym", "evidence": [ { "id": "NP_001192368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" } ] } ], "function": [ { "annotation": "A novel enzyme with spermine oxidase properties in bovine liver mitochondria has been isolated and characterized.", "evidence": [ { "database": "RefSeq", "id": "NP_001192368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" }, { "database": "PubMed", "id": "25591967", "url": "https://glygen.org/publication/PubMed/25591967" } ] }, { "annotation": "Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5#function" }, { "database": "UniProtKB", "id": "ARBA00057555", "url": "https://www.uniprot.org/uniprotkb/ARBA00057555#function" } ] }, { "annotation": "Homodimeric and monomeric SMOXs are catalytically active, as revealed after gel staining for enzymatic activity. An engineered SMOX mutant deprived of all but two cysteine residues was prepared and characterized experimentally, resulting in a monomeric species. High-sensitivity differential scanning calorimetry of SMOX was compared with that of bovine serum amine oxidase, to analyse their thermal stability.", "evidence": [ { "database": "RefSeq", "id": "NP_001192368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" }, { "database": "PubMed", "id": "27295021", "url": "https://glygen.org/publication/PubMed/27295021" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMOX", "url": "https://www.uniprot.org/uniprotkb/E1B7M5", "locus": { "chromosome": "13", "start_pos": 50949831, "end_pos": 50985484, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001112", "url": "https://www.ensembl.org/id/ENSBTAG00000001112" } ] } } ], "crossref": [ { "id": "E1B7M5", "url": "https://alphafold.ebi.ac.uk/entry/E1B7M5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001112", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001112", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527211", "url": "https://www.ncbi.nlm.nih.gov/gene/527211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527211", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527211", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CITGCHS", "url": "https://omabrowser.org/oma/group/CITGCHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7M5", "url": "https://www.orthodb.org/?gene=E1B7M5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742:SF416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742:SF416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01593", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141334", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141334", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-351200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "25804", "url": "https://www.rhea-db.org/rhea/25804", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T0T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0T3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSRIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNLTQEFFRHGKPVNAESQNSVGVFTREEVRNRIRDDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHVIPSGFMRVVELLAEGIPAHVIQLGKPVRCVHWDQASSRPRGPEIEPRDEGDHNHDAGEGSQGGEEPREERQDEDEQWPVVVECEDCEVIPADHVIVTVSLGVLKRQHASFFRPGLPAEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLRFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT", "length": 555, "header": "tr|E1B7M5-1|E1B7M5_BOVIN Isoform 1 of Spermine oxidase OS=Bos taurus OX=9913 GN=SMOX PE=3 SV=1 CANONICAL=E1B7M5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0T3/entry", "sequence": { "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSRIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNLTQEFFRHGKPVNAESQNSVGVFTREEVRNRIRDDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHVIPSGFMRVVELLAEGIPAHVIQLGKPVRCVHWDQASSRPRGPEIEPRDEGDHNHDAGEGSQGGEEPREERQDEDEQWPVVVECEDCEVIPADHVIVTVSLGVLKRQHASFFRPGLPAEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLRFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAQGSSSKQLPGHLLSSKCPEQSLEPNRGSIKPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT", "length": 585, "header": "tr|A0AAA9T0T3-1|E1B7M5_BOVIN Computationally mapped isoform of Spermine oxidase OS=Bos taurus OX=9913 GN=SMOX PE=3 SV=1 CANONICAL=E1B7M5-1" }, "locus": { "chromosome": "13", "start_pos": 50963516, "end_pos": 50950520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106374.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106374.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090161.1" } ] } }, { "isoform_ac": "A0AAA9T7S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S3/entry", "sequence": { "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSRIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT", "length": 190, "header": "tr|A0AAA9T7S3-1|E1B7M5_BOVIN Computationally mapped isoform of Spermine oxidase OS=Bos taurus OX=9913 GN=SMOX PE=3 SV=1 CANONICAL=E1B7M5-1" }, "locus": { "chromosome": "13", "start_pos": 50963516, "end_pos": 50950520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130230.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130230.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094786.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094786.1" } ] } }, { "isoform_ac": "E1B7M5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M5/entry", "sequence": { "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSRIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNLTQEFFRHGKPVNAESQNSVGVFTREEVRNRIRDDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHVIPSGFMRVVELLAEGIPAHVIQLGKPVRCVHWDQASSRPRGPEIEPRDEGDHNHDAGEGSQGGEEPREERQDEDEQWPVVVECEDCEVIPADHVIVTVSLGVLKRQHASFFRPGLPAEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLRFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT", "length": 555, "header": "tr|E1B7M5-1|E1B7M5_BOVIN Isoform 1 of Spermine oxidase OS=Bos taurus OX=9913 GN=SMOX PE=3 SV=1 CANONICAL=E1B7M5-1" }, "locus": { "chromosome": "13", "start_pos": 50963516, "end_pos": 50950520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001472.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001472.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001472.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001472.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "A novel enzyme with spermine oxidase properties in bovine liver mitochondria: identification and kinetic characterization.", "journal": "Free radical biology & medicine", "date": "2015-04", "authors": "Bonaiuto Emanuela, Grancara Silvia, Martinis Pamela, Stringaro Annarita, Colone Marisa, Agostinelli Enzo, Macone Alberto, Stevanato Roberto, Vianello Fabio, Toninello Antonio, Di Paolo Maria Luisa", "evidence": [ { "database": "RefSeq", "id": "NP_001192368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" } ], "reference": [ { "type": "PubMed", "id": "25591967", "url": "https://glygen.org/publication/PubMed/25591967" } ] }, { "title": "Stability of spermine oxidase to thermal and chemical denaturation: comparison with bovine serum amine oxidase.", "journal": "Amino acids", "date": "2016-10", "authors": "Cervelli Manuela, Leonetti Alessia, Cervoni Laura, Ohkubo Shinji, Xhani Marla, Stano Pasquale, Federico Rodolfo, Polticelli Fabio, Mariottini Paolo, Agostinelli Enzo", "evidence": [ { "database": "RefSeq", "id": "NP_001192368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192368" } ], "reference": [ { "type": "PubMed", "id": "27295021", "url": "https://glygen.org/publication/PubMed/27295021" } ] } ], "pathway": [ { "id": "bta:527211", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527211", "resource": "KEGG Pathway" }, { "id": "R-BTA-141334", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141334", "resource": "Reactome", "description": "PAOs oxidise polyamines to amines" }, { "id": "R-BTA-351200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351200", "resource": "Reactome", "description": "Interconversion of polyamines" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480QKQ3-1", "protein_name": "Spermine oxidase", "gene_name": "SMOX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQSCESSGDSADDPLSCGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTNVTVLEASSRIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHGKPVNAESQNSVGVFTREEVRNRIRDDPDEPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCVHWNQASACPRGPEIEPRGEGDHNHDAGEGSQGGEEPPGERQDEDEQWPVLVECEDCEVIPADHVIVTVSLGVLKRQHASFFQPGLPTEKVVAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESRTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYQDLFQQGT", "length": 555 }, "evidence": [ { "id": "E1B7M5", "url": "https://omabrowser.org/oma/group/E1B7M5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YPI2-1", "protein_name": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase", "gene_name": "SMOX", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSCEISGDSTDDPLSSGLRRTRQPRIVVIGAGLAGLSAAKALLESGFTDVTILEATDRIGGRVQSVKLGHATFELGATWIHGSHGNPVYHLAEDNGLLEETTDGERSVGRISLYSKNGVAYHLTNNGQRIPKDVVEEFSDLYNEVYNLTQEFFQRGKPVNAESQNSVGVFTRDVVRKRVKADPDDTEAVKRLKLAMIQQYLKVESCESSSHSMDEVSLSEFGEWTEIPGAHHIIPCGFIKIVEILARSIPESVIQLRKPVKCIHWNQSVSKEIERVADHNSDLPEEDRGSNVFVECEDCEFIPADHVIVTVSLGVLKKRHESLFHPRLPEEKVMAIEKLGINTTDKIFLEFEEPFWSSECNSIQFVWEDEAESESLTYPEELWYKKICSFDVLYPPERYGHVLSGWICGEEALIMEKCDDETVAETCTEMLRKFTGQPCPGSLGNPNIPKPRRILRSSWGSNPNFRGSYSYTQVGSSGADVEKLAKPLPYAESSKTTPMQVMFSGEATHRKYYSTTHGAVLSGQREAAHLIEMYQDLLQCRS", "length": 543 }, "evidence": [ { "id": "E1B7M5", "url": "https://omabrowser.org/oma/group/E1B7M5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B8A458-1", "protein_name": "Peroxisomal N(1)-acetyl-spermine/spermidine oxidase", "gene_name": "smox", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQSCEISSDSTDDPLSSALHGHRQPRIVVIGAGLAGLAATKTLLENGFTNVTVLEASDRIGGRVQSIQHGKTTLELGATWIHGANGNPVYHLAEDNGLLEHTTEEERSVGRISLYAKNGVAHYQTNNGKRIPKDLVEEFSDLYNEVYELTQEFFQNGKPVGAESQNSVGIFTRDVVRKKIMLDPYDSESIRKLKLSMLQQYLKVESCESSSPNMDEVSLSEFGEWTEIPGAHHVIPTGFIKVVEILAQDIPSCVLHLSKPVRRVHWNCSSQDAEEFGDQVDHNQDQRPSPSPVCVECEDGERLLADHVILTASLGVLKKAHKTLFSPGLPQDKAQAIQKLGISTTDKIFLEFAEPFWSPECNSIQFVWEDEAQLESQAYPEELWYRKICSFDVLYPPERYGHMLSGWICGEEALRMERCDDETVAEICTELLRQFTGNQNIPKPRRILRSSWGSNPYIRGSYSFTRVGSSGRDVEKLAEPLPYIKNTKAPPLQVLFAGEATHRKYYSTTHGALLSGQREANRLMELYQYSCAETTKPNI", "length": 539 }, "evidence": [ { "id": "E1B7M5", "url": "https://omabrowser.org/oma/group/E1B7M5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99K82-1", "protein_name": "Spermine oxidase", "gene_name": "Smox", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDVVEEFSDLYNEVYNMTQEFFRHGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPPHVIQLGKPVRCIHWDQASAHPRGPEIEPRGEGDHNHDTGEGGQSGENPQQGRWDEDEPWPVVVECEDCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGP", "length": 555 }, "evidence": [ { "id": "E1B7M5", "url": "https://omabrowser.org/oma/group/E1B7M5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NWM0-1", "protein_name": "Spermine oxidase", "gene_name": "SMOX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT", "length": 555 }, "evidence": [ { "id": "E1B7M5", "url": "https://omabrowser.org/oma/group/E1B7M5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHN8-1", "protein_name": "Amine oxidase domain-containing protein", "gene_name": "Dmel\\CG8032", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGDKEEPVTPAPSPTEEGMANIGSAGAGDQPQTSGNNTNVKIVIIGAGMAGLSAANHLLQNGCDDFLILEARGRVGGRIVSIPLSNNQKIELGANWIHGVLGNPIFELAVQHGLVSVVNVPKPHKVVATTEDGHQVPFNILQEIYEAYVCFLRRCDEYFLCQYSPPPDIHSVGEHINYEIEIYLSGVQDPKEKRLKQSIFNCLLKRETCITGCNNMDEVDLLELGSYTELQGGNIVLPTGYSSILRPLGAQIAKQSILTKCPVKKIHWKRKKTFTGLETVDENSEDEHSDDSERTVTEVPTGEIRGASVESNTSSNCDYPAGNVRIDCEDGRVFHAAHVICTIPLGVLKNTHRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDKRDMNSSEEELASEAYLSKNWFKKIYSFAKVTDTLLLGWVSGREAEYMEKLDHEAVAEKCTEILRNFLQDPYVPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLAQPLYATPQAMKPAIVFAGEHTHSSFYSTVHGAYLSGRTAAQHLLASDEPDEIIMESDGSDLSAWIQGIALD", "length": 583 }, "evidence": [ { "id": "E1B7M5", "url": "https://omabrowser.org/oma/group/E1B7M5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "polyamine catabolic process", "id": "GO:0006598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006598", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "spermine catabolic process", "id": "GO:0046208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046208", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "polyamine oxidase activity", "id": "GO:0046592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046592", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" }, { "name": "spermine oxidase activity", "id": "GO:0052901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052901", "evidence": [ { "database": "UniProtKB", "id": "E1B7M5", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25804", "name": "", "equation": "spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B7M5-1" ], "evidence": [ { "id": "25804", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25804" } ] }, { "id": "R-BTA-141341", "name": "SMOX-3 oxidises SPN to SPM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, peroxisomal matrix", "input_participant_list": [ "R-ALL-141342" ], "output_participant_list": [ "R-ALL-141328" ], "enzyme_list": [ "E1B7M5-1" ], "evidence": [ { "id": "R-BTA-141341", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141341" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-141328", "participant_name": "3APAL [peroxisomal matrix]", "crossref": [ { "id": "58374", "database": "ChEBI", "url": "" }, { "id": "HMDB0062210", "database": "HMDB Metabolite", "url": "" }, { "id": "C02229", "database": "COMPOUND", "url": "" }, { "id": "ZINC000001529387", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-141342", "participant_name": "SPN [peroxisomal matrix]", "crossref": [ { "id": "45725", "database": "ChEBI", "url": "" }, { "id": "ZINC000001532734", "database": "ZINC", "url": "" }, { "id": "C00750", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1B7M5", "gene_name": "SMOX", "activity": [ { "ec_number": "1.5.3.16", "activity": "norspermine + O2 + H2O = norspermidine + 3-aminopropanal + H2O2.", "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ] }, { "ec_number": "1.5.3.16", "activity": "", "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7M5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 555, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7M5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7M5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M5" }, { "id": "PF01593", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amine oxidase", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 267, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.5.3.16", "ec_name": "norspermine + O2 + H2O = norspermidine + 3-aminopropanal + H2O2.", "evidence": [ { "id": "1.5.3.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.16" }, { "id": "1.5.3.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.3.16" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA70-1", "uniprot_ac": "E1BA70", "uniprot_id": "E1BA70_BOVIN", "mass": { "chemical_mass": 92315.0, "monoisotopic_mass": 92315.0 }, "refseq": {}, "gene_names": [ { "name": "AOPEP", "type": "recommended", "evidence": [ { "id": "E1BA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA70" } ] } ], "protein_names": [ { "name": "Aminopeptidase O", "type": "recommended", "evidence": [ { "id": "E1BA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA70/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates.", "evidence": [ { "database": "UniProtKB", "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70#function" }, { "database": "UniProtKB", "id": "ARBA00060332", "url": "https://www.uniprot.org/uniprotkb/ARBA00060332#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AOPEP", "url": "https://www.uniprot.org/uniprotkb/E1BA70", "locus": { "chromosome": "8", "start_pos": 81619574, "end_pos": 81197307, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000699", "url": "https://www.ensembl.org/id/ENSBTAG00000000699" } ] } } ], "crossref": [ { "id": "E1BA70", "url": "https://alphafold.ebi.ac.uk/entry/E1BA70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000699", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000699", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531757", "url": "https://www.ncbi.nlm.nih.gov/gene/531757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR014782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BA70", "url": "https://www.orthodb.org/?gene=E1BA70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46627", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46627", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46627:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46627:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01433", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01433", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09127", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09127", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T144", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T144", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T144-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T144-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA70-1", "url": "https://www.uniprot.org/uniprotkb/E1BA70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N085", "url": "https://www.uniprot.org/uniprotkb/G3N085", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N085-1", "url": "https://www.uniprot.org/uniprotkb/G3N085-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDIKLDPSRDDLPLVANTSHILVKHYVLDLDVDFESQVIGGTIVLFLESGNRFKKRSSSTEVACPSESNEACKFRMPEPCQIPVTNTKTFSSKIGYNDFVICGKGEKDTSGKDGNHDNQEQASGISSSKYCCDTGNHGSEEFLLVLDCCDLSVLKVEEVDVAAVPGIEKFTRSPKLRNQIVHEVMALPADRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIQYRTKPQGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLQEDYSSWHYYVTMPMPASTFTIAVGSWTEMKPEICSSNDVATERSFSPSEADFRYIGVCGHMEYPCRFQKASATTQKIIPHRVFAPACLKGACQETLLPLIPPCLSAAHSVLGTHPFSRLDILIVPANFSSLGMASPHIVFLSQSTLTGMSQLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWAKAQQLAPHEAREQQELRACLRWRRLQDEVQNSPEEMQVLRPNKEKTGHVSDSGSSVIRHGLNPEKVFMQVHYLKGYFLLRFLAKRLGEDTYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRPELSVGNIFRDWLESSGIPQPLQRERQALAECGLAQQVSAEVAKWVRVNRRPRKRKRKDREEVFEKLLPDQLVLLLEHLLEQKTVTPRTLQSLERIYRLSEQDAEVRHRWCELIVKHKYTKAYRDVERFLQEDQAMGIYLYGELMLSEDPRQQHLARRCFELSREQMDKSSAEVVAEMLF", "length": 812, "header": "tr|E1BA70-1|E1BA70_BOVIN Isoform 1 of Aminopeptidase O OS=Bos taurus OX=9913 GN=AOPEP PE=3 SV=4 CANONICAL=E1BA70-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T144-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T144/entry", "sequence": { "sequence": "MDIKLDPSRDDLPLVANTSHILVKHYVLDLDVDFESQVIGGTIVLFLESGNRFKKRSSSTEVACPSESNEACKFRMPEPCQIPVTNTKTFSSKIGYNDFVICGKGEKDTSGKDGNHDNQEQASGISSSKYCCDTGNHGSEEFLLVLDCCDLSVLKVEEVDVAAVPGIEKFTRSPKLRNQIVHEVMALPADRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIQYRTKPQGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLQEDYSSWHYYVTMPMPASTFTIAVGSWTEMKPEICSSNDVATERSFSPSEADFRYIGVCGHMEYPCRFQKASATTQKIIPHRVFAPACLKGACQETLLPLIPPCLSAAHSVLGTHPFSRLDILIVPANFSSLGMASPHIVFLSQSTLTGMSQLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWAKAQQLAPHEAREQQELRACLRWRRLQDEVQNSPEEMQVLRPNKEKTGHVSDSGSSVIRHGLNPEKVFMQVHYLKGYFLLRFLAKRLGEDTYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRPELSVGNIFRDWLESSGIPQPLQRERQALAECGLAQQVSAEVAKWVRVNRRPRKRKRKDREEVFEKVRHRWCELIVKHKYTKAYRDVERFLQEDQAMGIYLYGELMLSEDPRQQHLARRCFELSREQMDKSSAEVVAEMLF", "length": 773, "header": "tr|A0AAA9T144-1|E1BA70_BOVIN Computationally mapped isoform of Aminopeptidase O OS=Bos taurus OX=9913 GN=AOPEP PE=3 SV=1 CANONICAL=E1BA70-1" }, "locus": { "chromosome": "8", "start_pos": 81615170, "end_pos": 81266207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102365.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102365.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089373.1" } ] } }, { "isoform_ac": "E1BA70-1", "url": "https://www.uniprot.org/uniprotkb/E1BA70/entry", "sequence": { "sequence": "MDIKLDPSRDDLPLVANTSHILVKHYVLDLDVDFESQVIGGTIVLFLESGNRFKKRSSSTEVACPSESNEACKFRMPEPCQIPVTNTKTFSSKIGYNDFVICGKGEKDTSGKDGNHDNQEQASGISSSKYCCDTGNHGSEEFLLVLDCCDLSVLKVEEVDVAAVPGIEKFTRSPKLRNQIVHEVMALPADRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIQYRTKPQGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLQEDYSSWHYYVTMPMPASTFTIAVGSWTEMKPEICSSNDVATERSFSPSEADFRYIGVCGHMEYPCRFQKASATTQKIIPHRVFAPACLKGACQETLLPLIPPCLSAAHSVLGTHPFSRLDILIVPANFSSLGMASPHIVFLSQSTLTGMSQLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWAKAQQLAPHEAREQQELRACLRWRRLQDEVQNSPEEMQVLRPNKEKTGHVSDSGSSVIRHGLNPEKVFMQVHYLKGYFLLRFLAKRLGEDTYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRPELSVGNIFRDWLESSGIPQPLQRERQALAECGLAQQVSAEVAKWVRVNRRPRKRKRKDREEVFEKLLPDQLVLLLEHLLEQKTVTPRTLQSLERIYRLSEQDAEVRHRWCELIVKHKYTKAYRDVERFLQEDQAMGIYLYGELMLSEDPRQQHLARRCFELSREQMDKSSAEVVAEMLF", "length": 812, "header": "tr|E1BA70-1|E1BA70_BOVIN Isoform 1 of Aminopeptidase O OS=Bos taurus OX=9913 GN=AOPEP PE=3 SV=4 CANONICAL=E1BA70-1" }, "locus": { "chromosome": "8", "start_pos": 81615170, "end_pos": 81266207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000938.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000938.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000938.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000938.7" } ] } }, { "isoform_ac": "G3N085-1", "url": "https://www.uniprot.org/uniprotkb/G3N085/entry", "sequence": { "sequence": "MDIKLDPSRDDLPLVANTSHILVKHYVLDLDVDFESQVIGGTIVLFLESGNRFKKRSSSTEVACPSESNEACKFRMPEPCQIPVTNTKTFSSKIGYNDFVICGKGEKDTSGKDGNHDNQEQASGISSSKYCCDTGNHGSEEFLLVLDCCDLSVLKVEEVDVAAVPGIEKFTRSPKLRNQIVHEVMALPADRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIQYRTKPQGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLQEDYSSWHYYVTMPMPASTFTIAVGSWTEMKPEICSSNDVATERSFSPSEADFRYIGVCGHMEYPCRFQKASATTQKIIPHRVFAPACLKGACQETLLPLIPPCLSAAHSVLGTHPFSRLDILIVPANFSSLGMARPNKEKTGHVSDSGSSVIRHGLNPEKVFMQVHYLKGYFLLRFLAKRLGEDTYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRPELSVGNIFRDWLESSGIPQPLQRERQALAECGLAQQVSAEVAKWVRVNRRPRKRKRKDREEVFEKLLPDQLVLLLEHLLEQKTVTPRTLQSLERIYRLSEQDAEVRHRWCELIVKHKYTKAYRDVERFLQEDQAMGIYLYGELMLSEDPRQQHLARRCFELSREQMDKSSAEVVAEMLF", "length": 713, "header": "tr|G3N085-1|E1BA70_BOVIN Computationally mapped isoform of Aminopeptidase O OS=Bos taurus OX=9913 GN=AOPEP PE=3 SV=3 CANONICAL=E1BA70-1" }, "locus": { "chromosome": "8", "start_pos": 81615170, "end_pos": 81266207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065565.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065565.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055242.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055242.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531757", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531757", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70" } ], "pmid": "" }, { "name": "metalloaminopeptidase activity", "id": "GO:0070006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070006", "evidence": [ { "database": "UniProtKB", "id": "E1BA70", "url": "https://www.uniprot.org/uniprotkb/E1BA70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA70-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 812, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA70-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA70" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA70" }, { "id": "SM01263", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01263" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal", "eco_id": "ECO_0000259", "start_pos": 665, "end_pos": 811, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 }, { "start_pos": 440, "end_pos": 442 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QPE7-1", "uniprot_ac": "A6QPE7", "uniprot_id": "ANR65_BOVIN", "mass": { "chemical_mass": 41106.0, "monoisotopic_mass": 41106.0 }, "refseq": { "ac": "NP_001095819", "name": "ankyrin repeat domain-containing protein 65", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095819" }, "gene_names": [ { "name": "ANKRD65", "type": "recommended", "evidence": [ { "id": "A6QPE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPE7" } ] }, { "name": "ANKRD65", "type": "synonym", "evidence": [ { "id": "NP_001095819", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095819" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain-containing protein 65", "type": "recommended", "evidence": [ { "id": "A6QPE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPE7/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 65", "type": "synonym", "evidence": [ { "id": "NP_001095819", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095819" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QPE7", "url": "https://www.uniprot.org/uniprotkb/A6QPE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD65", "url": "https://www.uniprot.org/uniprotkb/A6QPE7", "locus": { "chromosome": "16", "start_pos": 51128060, "end_pos": 51125124, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039055", "url": "https://www.ensembl.org/id/ENSBTAG00000039055" } ] } } ], "crossref": [ { "id": "A6QPE7", "url": "https://alphafold.ebi.ac.uk/entry/A6QPE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039055", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039055", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "788407", "url": "https://www.ncbi.nlm.nih.gov/gene/788407", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788407", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788407", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRWGDMA", "url": "https://omabrowser.org/oma/group/TRWGDMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QPE7", "url": "https://www.orthodb.org/?gene=A6QPE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24193", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24193", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24193:SF121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24193:SF121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095819", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T151", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T151", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T151-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T151-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPE7", "url": "https://www.uniprot.org/uniprotkb/A6QPE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPE7-1", "url": "https://www.uniprot.org/uniprotkb/A6QPE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPDSCCFQMDSGVSEPGEQDLTEAGAEQELRWLDLGSEEALGAGTQGPSTPQAWGHLLQAVWKGHTGLVTQLLRQGASVEERDGAGRTPLHLAVLRGHVSLVRLLLQRGAQVGAADRAGRTPLHEAAWHGPSRVAELLLRRGAPANARCLAGLTPLHWAAALGRTLMVGHLLAAPHPGPTAADARGWTAGHWAAAGGQMAVLELLGANGGARLDSVLLVAAAAGRATALRLLLAQGAPVDARDGVGATVLGVAAGLGRRQDMEVLLEHGADPSLTDRHGRSALHRAAAGGHLLAVQLLAAWGAEVDSQDLLGLTPLHHAARGGHIEVTGHLLDRGAEINAAGWLHKTPLHLAMEHGHGPTAELLLSRGASPTLRTRWGDMAQDLWPALCGEQEES", "length": 395, "header": "sp|A6QPE7-1|ANR65_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 65 OS=Bos taurus OX=9913 GN=ANKRD65 PE=2 SV=1 CANONICAL=A6QPE7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T151-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T151/entry", "sequence": { "sequence": "MPDSCCFQMDSGVSEPGEQDLTEAGAEQELRWLDLGSEEALGAGTQGPSTPQAWGHLLQAVWKGHTGLVTQLLRQGASVEERDGAGRTPLHLAVLRGHVSLVRLLLQRGAQVGAADRAGRTPLHEAAWHGPSRVAELLLRRGAPANARCLAGLTPLHWAAALGRTLMVGHLLAAPHPGPTAADARGWTAGHWAAAGGQMAVLELLGANGGARLDSVLLVAAAAGRATALRLLLAQGAPVDARDGVGATVLGVAAGLGRRQAPLFVGFSRQEYWSGFHALLQGIFLTQGSNTHLLCFLYWHADSLPQRHLGSPHRTWRCCLSTGQTQASRTGMAALHSTGLLRVDICLPSSCWPPGEQKWILRTCWASPPCTMLPGEAT", "length": 378, "header": "tr|A0AAA9T151-1|ANR65_BOVIN Computationally mapped isoform of Ankyrin repeat domain-containing protein 65 OS=Bos taurus OX=9913 GN=ANKRD65 PE=2 SV=1 CANONICAL=A6QPE7-1" }, "locus": { "chromosome": "16", "start_pos": 51127216, "end_pos": 51125248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093922.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093922.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090289.1" } ] } }, { "isoform_ac": "A6QPE7-1", "url": "https://www.uniprot.org/uniprotkb/A6QPE7/entry#A6QPE7-1", "sequence": { "sequence": "MPDSCCFQMDSGVSEPGEQDLTEAGAEQELRWLDLGSEEALGAGTQGPSTPQAWGHLLQAVWKGHTGLVTQLLRQGASVEERDGAGRTPLHLAVLRGHVSLVRLLLQRGAQVGAADRAGRTPLHEAAWHGPSRVAELLLRRGAPANARCLAGLTPLHWAAALGRTLMVGHLLAAPHPGPTAADARGWTAGHWAAAGGQMAVLELLGANGGARLDSVLLVAAAAGRATALRLLLAQGAPVDARDGVGATVLGVAAGLGRRQDMEVLLEHGADPSLTDRHGRSALHRAAAGGHLLAVQLLAAWGAEVDSQDLLGLTPLHHAARGGHIEVTGHLLDRGAEINAAGWLHKTPLHLAMEHGHGPTAELLLSRGASPTLRTRWGDMAQDLWPALCGEQEES", "length": 395, "header": "sp|A6QPE7-1|ANR65_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 65 OS=Bos taurus OX=9913 GN=ANKRD65 PE=2 SV=1 CANONICAL=A6QPE7-1" }, "locus": { "chromosome": "16", "start_pos": 51127428, "end_pos": 51125248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056210.2", "url": "https://www.ensembl.org/id/ENSBTAT00000056210.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000051383.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 180, "start_aa": "Thr", "end_pos": 180, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr180", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:788407", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788407", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E5RJM6-1", "protein_name": "Ankyrin repeat domain-containing protein 65", "gene_name": "ANKRD65", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSQRPEPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGGGEKECEGIESTG", "length": 399 }, "evidence": [ { "id": "A6QPE7", "url": "https://omabrowser.org/oma/group/A6QPE7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QPE7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 395, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QPE7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QPE7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 180 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBC2-1", "uniprot_ac": "E1BBC2", "uniprot_id": "E1BBC2_BOVIN", "mass": { "chemical_mass": 65159.0, "monoisotopic_mass": 65159.0 }, "refseq": { "ac": "XP_005205800", "name": "transmembrane protein 209 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205800" }, "gene_names": [ { "name": "TMEM209", "type": "recommended", "evidence": [ { "id": "E1BBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC2" } ] }, { "name": "TMEM209", "type": "synonym", "evidence": [ { "id": "XP_005205800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205800" } ] } ], "protein_names": [ { "name": "Transmembrane protein 209", "type": "recommended", "evidence": [ { "id": "E1BBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC2/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 209 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005205800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205800" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBC2", "url": "https://www.uniprot.org/uniprotkb/E1BBC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM209", "url": "https://www.uniprot.org/uniprotkb/E1BBC2", "locus": { "chromosome": "4", "start_pos": 93951778, "end_pos": 93983190, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015588", "url": "https://www.ensembl.org/id/ENSBTAG00000015588" } ] } } ], "crossref": [ { "id": "E1BBC2", "url": "https://alphafold.ebi.ac.uk/entry/E1BBC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "510567", "url": "https://www.ncbi.nlm.nih.gov/gene/510567", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IRGMHLG", "url": "https://omabrowser.org/oma/group/IRGMHLG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBC2", "url": "https://www.orthodb.org/?gene=E1BBC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21780", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21780", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21780:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21780:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09786", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09786", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005205800", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205800", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC2", "url": "https://www.uniprot.org/uniprotkb/E1BBC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWPDHPLPVVEGRKEAIGVAKMQGEPNPSASLIDRTIKMRRETEARKVVLAWGLLNVSMAGMIYTEMTGKLISSYYNVTYWPLWYIELALASLFSLNALFDFWRYFKCTVAATSLVVSPEQQTLLGLKTAVVQTTPPRDLAAAQIPPSPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCITGYSPQLQGLSSGGSGSYSPGVTYSPISGYNKLASYSPSPPPPYPTTVGPVESSGLRSRYRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQQRVKLGSPDSTSPPTSPTFWNYSRSVGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGEASITSLKQAALVKAPLIPTLNTIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 581, "header": "tr|E1BBC2-1|E1BBC2_BOVIN Isoform 1 of Transmembrane protein 209 OS=Bos taurus OX=9913 GN=TMEM209 PE=4 SV=2 CANONICAL=E1BBC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E4/entry", "sequence": { "sequence": "TMQGEPNPSASLIDRTIKMRRETEARKVVLAWGLLNVSMAGMIYTEMTGKLISSYYNVTYWPLWYLALASLFSLNALFDFWRYFKCTVAATSLVVSPEQQTLLGLKTAVVQTTPPRDLAAAQIPPSPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCITGYSPQLQGLSSGGSGSYSPGVTYSPISGYNKLASYSPSPPPPYPTTVGPVESSGLRSRYRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQQRVKLGSPDSTSPPTSPTFWNYSRSVGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 517, "header": "tr|A0AAA9T1E4-1|E1BBC2_BOVIN Computationally mapped isoform of Transmembrane protein 209 OS=Bos taurus OX=9913 GN=TMEM209 PE=4 SV=1 CANONICAL=E1BBC2-1" }, "locus": { "chromosome": "4", "start_pos": 93982947, "end_pos": 93952782, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098392.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098392.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092598.1" } ] } }, { "isoform_ac": "E1BBC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC2/entry", "sequence": { "sequence": "MWPDHPLPVVEGRKEAIGVAKMQGEPNPSASLIDRTIKMRRETEARKVVLAWGLLNVSMAGMIYTEMTGKLISSYYNVTYWPLWYIELALASLFSLNALFDFWRYFKCTVAATSLVVSPEQQTLLGLKTAVVQTTPPRDLAAAQIPPSPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCITGYSPQLQGLSSGGSGSYSPGVTYSPISGYNKLASYSPSPPPPYPTTVGPVESSGLRSRYRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQQRVKLGSPDSTSPPTSPTFWNYSRSVGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGEASITSLKQAALVKAPLIPTLNTIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 581, "header": "tr|E1BBC2-1|E1BBC2_BOVIN Isoform 1 of Transmembrane protein 209 OS=Bos taurus OX=9913 GN=TMEM209 PE=4 SV=2 CANONICAL=E1BBC2-1" }, "locus": { "chromosome": "4", "start_pos": 93982843, "end_pos": 93952782, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020713.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020713.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020713.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020713.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 225, "start_aa": "Thr", "end_pos": 225, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr225", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VZE5-1", "protein_name": "Transmembrane protein 209", "gene_name": "TMEM209", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQGEPNPSASLIDRTIKMRKETEARKVVLAWGLLNVSMAGMIYTEMTGKLISSYYNVTYWPLWYIELALASLFSLNALFDFWRYFKYTVAPTSLVVSPGQQTLLGLKTAVVQTTPPRDLAATQIPSSPPPSIQGQSVLSYSPSRSPSTSPKFTTSCITGYSPQLQGLSSGGSGSYSPGVTFSPVSGYNKLASYSPSPSSSYPTTVGPVESSGLRSRYRSSPTIYNSPTDKEDYMTDLRTLDTFLRNEEEKQHRVKLGSPDSTSPSTSPTFWNYSRSVGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGEASITSLKQAALVKAPLIPTLNTIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCVYQSAINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 559 }, "evidence": [ { "id": "E1BBC2", "url": "https://omabrowser.org/oma/group/E1BBC2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1N9C5-1", "protein_name": "Transmembrane protein 209", "gene_name": "TMEM209", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTPEQSPATSLIDRTIKMRKETEARKVVLAWGLLNVSFAGMIYTEMTGKLISTYYNITYWPLWYIELAFASLFSLNALFDFWRYFKYTVAPTSLVMSPGQQTLLGLQNTAVQTTPPRELTAKKVPSSTPSPPIQGQSVLSYSPSRSPSASPKFATSCIPGYSPQLQALSNNSASYSSTIAYSPGSTYNKISNFSPSPGGSPYPTSIGPMESGGLRSRYRSSPILYNSPTGKEDYMTDLKSLDTFLRSEEEKQHRVQLGSSDSSSPSSSPTFWNYSRSMGDYAQILRKFQYQLACRSQAPSAHKDEADLSSKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQLRRMGCPELQIGEASISSLKQAALVKAPLIPTLNAIVQYLDLTPNQEYLVERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSSIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFIQTPDKPDTSNENVFCIYQSSINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNVLWIFGE", "length": 560 }, "evidence": [ { "id": "E1BBC2", "url": "https://omabrowser.org/oma/group/E1BBC2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F6P528-1", "protein_name": "Transmembrane protein 209", "gene_name": "tmem209", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTPSKEGMTSLIERTIKLRKEEQARQVVLAWAVLNMSLAGMIYTEMSGKLLSRYYNITYWPIWYIELALASLFSLNALFDFWKYFKYTMAPSTIVVSPDQHRLLGLRGSGIQASPPQKQEKKEAPVSVQSSPLQGQNVLSFSPARPSSTSPKFSPSCVSGFSPPLSSTSSGGPFSPSMSFGKVLNYSPSQSSPPYPSSLGPAENTSLRSRYRTSPSVFNSPGGKEDCIDDLKTLEKFLRSEEEKSHRSQLGSPESTSPRHSPSFWNYNRTVGDYAQSLRKFQYQPACRSQAPSAHKDDTELGSKQAAEEVWARITTSRLVTDSIDSWTAKLRNWINDTILVHLVKEMDSINSQLRRMGCPELQIGEASISSLKQAAVVKASAIPTLNAIVQYLDVTPNQEYLVERIKELAHSGCMSSFRWNGGGDLKNRKWDTDLPTDSAILMHVLCTYLDSRLPPHPKYPDGKTFTSQHFMQTPNKPDVSNENLFCIHQSSTNPPHYQLVYQGHVYSLPKGRNNLFHTILMFLYIIKTKESGMLGRVNLGLSGVNVLWIFGD", "length": 553 }, "evidence": [ { "id": "E1BBC2", "url": "https://omabrowser.org/oma/group/E1BBC2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q68FR5-1", "protein_name": "Transmembrane protein 209", "gene_name": "Tmem209", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMQGEVSPSPSLIDRTIRMRKETESRKVVLAWGLLNVSMAGMIYTEMTGKLISTYYNVTYWPLWYIELALASLFSLNALFDFWRYFKYTVAPTSLVVSPGQQTLLGLKPAVVQTTPPRDLAATQISPSPPSPSIQGQSVLSYSPSRSPSTSPKFATSCMTGYSPQLQGLSSGGLGSYSPAVTYSPVSGYSKLASFSLSPSSPYPTTVGPVESSGLRARYRSPPTAYNSPTDKEDYMTDLRTLDTFLRSEEEKQHRVKLGSPDSTSPSTSPTFWNYSRSVGDYAQTLKKFQYQLACRSQAPCANKDEADLISKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWISETILVPLVQEIESVSTQMRRMGCPELQIGEASVTSLKQAALVKAPLIPTLNAIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRRWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCVYQSAINPPHYELIYQRHVYSLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 561 }, "evidence": [ { "id": "E1BBC2", "url": "https://omabrowser.org/oma/group/E1BBC2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BRG8-1", "protein_name": "Transmembrane protein 209", "gene_name": "Tmem209", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMQGDVSPNPSLIDRTIKMRKETETRKVVLAWGLLNVSMAGMIYTEMTGKLISTYYNVTYWPLWYIELALASLFSLNALFDFWRYFKYTVAPTSLVVSPGQQALLGLKQAVVQTTPPRDLAATQISPSPPSPSIQGQSVLSYSPSRSPSTSPKFATSCMTGYSPQLQGLSSGGLGSYSPGVTYSPVSGYNKLASFSLSPSSPYPTTVGPVESSGLRARYRSPPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQHRVKLGSPDSTSPSTSPTFWNYSRSVGDYAQTLKKFQYQLACRSQAPCANKDEADLISKQAAEEVWARVTMNRQLLDHMDSWTAKFRNWISETILVPLVQEIESVSTQMRRMGCPELQIGEASVTSLKQAALVRAPLIPTLNAIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAVNPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 561 }, "evidence": [ { "id": "E1BBC2", "url": "https://omabrowser.org/oma/group/E1BBC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96SK2-1", "protein_name": "Transmembrane protein 209", "gene_name": "TMEM209", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMQGEAHPSASLIDRTIKMRKETEARKVVLAWGLLNVSMAGMIYTEMTGKLISSYYNVTYWPLWYIELALASLFSLNALFDFWRYFKYTVAPTSLVVSPGQQTLLGLKTAVVQTTPPHDLAATQIPPAPPSPSIQGQSVLSYSPSRSPSTSPKFTTSCMTGYSPQLQGLSSGGSGSYSPGVTYSPVSGYNKLASFSPSPPSPYPTTVGPVESSGLRSRYRSSPTVYNSPTDKEDYMTDLRTLDTFLRSEEEKQHRVKLGSPDSTSPSSSPTFWNYSRSMGDYAQTLKKFQYQLACRSQAPCANKDEADLSSKQAAEEVWARVAMNRQLLDHMDSWTAKFRNWINETILVPLVQEIESVSTQMRRMGCPELQIGEASITSLKQAALVKAPLIPTLNTIVQYLDLTPNQEYLFERIKELSQGGCMSSFRWNRGGDFKGRKWDTDLPTDSAIIMHVFCTYLDSRLPPHPKYPDGKTFTSQHFVQTPNKPDVTNENVFCIYQSAINPPHYELIYQRHVYNLPKGRNNMFHTLLMFLYIIKTKESGMLGRVNLGLSGVNILWIFGE", "length": 561 }, "evidence": [ { "id": "E1BBC2", "url": "https://omabrowser.org/oma/group/E1BBC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BBC2", "url": "https://www.uniprot.org/uniprotkb/E1BBC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 581, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBC2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBC2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 225 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 294, "end_pos": 296 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBP5-1", "uniprot_ac": "E1BBP5", "uniprot_id": "E1BBP5_BOVIN", "mass": { "chemical_mass": 44417.0, "monoisotopic_mass": 44417.0 }, "refseq": { "ac": "XP_010801062", "name": "V-set and immunoglobulin domain-containing protein 8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801062" }, "gene_names": [ { "name": "VSIG8", "type": "recommended", "evidence": [ { "id": "E1BBP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBP5" } ] }, { "name": "VSIG8", "type": "synonym", "evidence": [ { "id": "XP_010801062", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801062" } ] } ], "protein_names": [ { "name": "V-set and immunoglobulin domain containing 8", "type": "synonym", "evidence": [ { "id": "E1BBP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBP5/entry#names_and_taxonomy" } ] }, { "name": "V-set and immunoglobulin domain-containing protein 8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010801062", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801062" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBP5", "url": "https://www.uniprot.org/uniprotkb/E1BBP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VSIG8", "url": "https://www.uniprot.org/uniprotkb/E1BBP5", "locus": { "chromosome": "3", "start_pos": 9834567, "end_pos": 9825411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010670", "url": "https://www.ensembl.org/id/ENSBTAG00000010670" } ] } } ], "crossref": [ { "id": "E1BBP5", "url": "https://alphafold.ebi.ac.uk/entry/E1BBP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010670", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010670", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520493", "url": "https://www.ncbi.nlm.nih.gov/gene/520493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PSPIYVK", "url": "https://omabrowser.org/oma/group/PSPIYVK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBP5", "url": "https://www.orthodb.org/?gene=E1BBP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45166:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45166:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010801062", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801062", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T246", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T246", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T246-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T246-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBP5", "url": "https://www.uniprot.org/uniprotkb/E1BBP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVRGAFHLLLACLSPALLSAVRINGDGQEILYLAEGDNVRLGCPYILDPEDYGPNGLDIEWKQVNSDPSHRENVFLSYQDKTINHGNLPHLQQRVRFAASDPSQYDASITLSNLQVSDTATYECRVKKTTVATRRVIITVQARPAVPLCWSEGHFTHGNDVVLKCFANGGSPPLTYKWAKISGHTHPYRAGSYHSQHSFHSELSYHESFHSSISQVSGLNNGDLVLKDISYKDDGLYQCTVANHVGYSVCVVEVKVSDTRRIGIIIGAVLGSLLALGCLLVGIWGLVCCCCGGAGVGGGSRGAFGYGGGVGGGVGGGACGDLSNEIREDAVAPGCKASGRGNRVTHLLGYPTQNVSRSLRRKYAPQPCGGPEDVALAARPAPAAAACEAGPSPVYVQVKSAEPASSTAEGPLQSKDGLLV", "length": 421, "header": "tr|E1BBP5-1|E1BBP5_BOVIN Isoform 1 of V-set and immunoglobulin domain containing 8 OS=Bos taurus OX=9913 GN=VSIG8 PE=4 SV=1 CANONICAL=E1BBP5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T246-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T246/entry", "sequence": { "sequence": "LLGRECLISYDLTHSVKSQWIRHYHSCFSSKKAESQGSSVNCPRQPIHKAFLGSTCLTISVFFSSQFLSYQDKTINHGNLPHLQQRVRFAASDPSQYDASITLSNLQVSDTATYECRVKKTTVATRRVIITVQARPAVPLCWSEGHFTHGNDVVLKCFANGGSPPLTYKWAKISGHTHPYRAGSYHSQHSFHSELSYHESFHSSISQVSGLNNGDLVLKDISYKDDGLYQCTVANHVGYSVCVVEVKVSDTRRIGIIIGAVLGSLLALGCLLVGIWGLVCCCCGGAGVGGGSRGAFGYGGGVGGGVGGGACGDLSNEIREDAVAPGCKASGRGNRVTHLLGYPTQNVSRSLRRKYAPQPCGGPEDVALAARPAPAAAACEAGPSPVYVQVKSAEPASSTAEGPLQSKDGLLVRSWAPEVFLLLPCGHVNCGEWMDLGVC", "length": 439, "header": "tr|A0AAA9T246-1|E1BBP5_BOVIN Computationally mapped isoform of V-set and immunoglobulin domain containing 8 OS=Bos taurus OX=9913 GN=VSIG8 PE=4 SV=1 CANONICAL=E1BBP5-1" }, "locus": { "chromosome": "3", "start_pos": 9834535, "end_pos": 9829624, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090702.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090702.1" } ] } }, { "isoform_ac": "E1BBP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBP5/entry", "sequence": { "sequence": "MGVRGAFHLLLACLSPALLSAVRINGDGQEILYLAEGDNVRLGCPYILDPEDYGPNGLDIEWKQVNSDPSHRENVFLSYQDKTINHGNLPHLQQRVRFAASDPSQYDASITLSNLQVSDTATYECRVKKTTVATRRVIITVQARPAVPLCWSEGHFTHGNDVVLKCFANGGSPPLTYKWAKISGHTHPYRAGSYHSQHSFHSELSYHESFHSSISQVSGLNNGDLVLKDISYKDDGLYQCTVANHVGYSVCVVEVKVSDTRRIGIIIGAVLGSLLALGCLLVGIWGLVCCCCGGAGVGGGSRGAFGYGGGVGGGVGGGACGDLSNEIREDAVAPGCKASGRGNRVTHLLGYPTQNVSRSLRRKYAPQPCGGPEDVALAARPAPAAAACEAGPSPVYVQVKSAEPASSTAEGPLQSKDGLLV", "length": 421, "header": "tr|E1BBP5-1|E1BBP5_BOVIN Isoform 1 of V-set and immunoglobulin domain containing 8 OS=Bos taurus OX=9913 GN=VSIG8 PE=4 SV=1 CANONICAL=E1BBP5-1" }, "locus": { "chromosome": "3", "start_pos": 9832941, "end_pos": 9825545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014115.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014115.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014115.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014115.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D4A7V8-1", "protein_name": "V-set and immunoglobulin domain containing 8", "gene_name": "Vsig8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVRGAFHLLLVCLSPALLSAVRINGDGQEVLFLAEGDNVRLGCPYILDPEDYGPNGLDIEWMQVNSEPSHRENVFLTYQDKRISHGNLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYECRVKKTTMATRKVVVTVQARPAVPMCWTEGHMSKGNDVVLKCFANGGSQPLSYKWAKISGHSHPYRAGSYHSQHSFHSELSYQESFHSSINQGLSNGDLVLKGVNADDDGLYQCTVANHVGYSVCVVEVKVSDSQRVGMIVGAVLGSLLMLACLAVGIWGLICCCCGGAGAGGARGAFGYGVGGGVGGGACGDLASEIRVDAEAPGCKASGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALVPRTTSAACEAGPSPVYIKVKSAEPADCADCAQVEQRSCKDGLLV", "length": 417 }, "evidence": [ { "id": "E1BBP5", "url": "https://omabrowser.org/oma/group/E1BBP5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0DPA2-1", "protein_name": "V-set and immunoglobulin domain-containing protein 8", "gene_name": "VSIG8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVGGAFHLLLVCLSPALLSAVRINGDGQEVLYLAEGDNVRLGCPYVLDPEDYGPNGLDIEWMQVNSDPAHHRENVFLSYQDKRINHGSLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYECRVKKTTMATRKVIVTVQARPAVPMCWTEGHMTYGNDVVLKCYASGGSQPLSYKWAKISGHHYPYRAGSYTSQHSYHSELSYQESFHSSINQGLNNGDLVLKDISRADDGLYQCTVANNVGYSVCVVEVKVSDSRRIGVIIGIVLGSLLALGCLAVGIWGLVCCCCGGSGAGGARGAFGYGNGGGVGGGACGDLASEIREDAVAPGCKASGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALAPCTAAAACEAGPSPVYVKVKSAEPADCAEGPVQCKNGLLV", "length": 414 }, "evidence": [ { "id": "E1BBP5", "url": "https://omabrowser.org/oma/group/E1BBP5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P3A4-1", "protein_name": "V-set and immunoglobulin domain-containing protein 8", "gene_name": "Vsig8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVRGALHLLLVCLSPALLSAVRINGDGQEVMYLAEGDNVRLGCPYLLDPEDLGTNSLDIEWMQVNSEPSHRENVFLTYQDKRIGHGNLPHLQQRVRFAASDPSQYDASINLMNLQVSDTATYECRVKKTTMATRKVIVTVQARPAVPMCWTEGHMSKGNDVVLKCFANGGSQPLSYKWAKISGHSHPYRAGAYHSQHSFHSELSYQESFHSTINQGLGNGDLLLKGINADDDGLYQCTVANHVGYSVCVVEVKVSDSQRVGMIVGAVLGSLLMLACLALGIWGLICCCCGGGGAGGARGAFGYGVGGGVGGGACGDLASEIRVDAEAPGCKASGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALVPRTASASCEAGPSPVYIKVKSAEPADCADCAQVEQRSCKDGLLV", "length": 417 }, "evidence": [ { "id": "E1BBP5", "url": "https://omabrowser.org/oma/group/E1BBP5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBP5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 140, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 355, "end_pos": 357 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B808-1", "uniprot_ac": "E1B808", "uniprot_id": "E1B808_BOVIN", "mass": { "chemical_mass": 147590.0, "monoisotopic_mass": 147590.0 }, "refseq": {}, "gene_names": [ { "name": "NCKAP5L", "type": "recommended", "evidence": [ { "id": "E1B808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B808" } ] } ], "protein_names": [ { "name": "NCK associated protein 5 like", "type": "synonym", "evidence": [ { "id": "E1B808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B808/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B808", "url": "https://www.uniprot.org/uniprotkb/E1B808" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCKAP5L", "url": "https://www.uniprot.org/uniprotkb/E1B808", "locus": { "chromosome": "5", "start_pos": 30097261, "end_pos": 30062457, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004851", "url": "https://www.ensembl.org/id/ENSBTAG00000004851" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004851", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004851", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504364", "url": "https://www.ncbi.nlm.nih.gov/gene/504364", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504364", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504364", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SWPACGP", "url": "https://omabrowser.org/oma/group/SWPACGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3MZN5", "url": "https://www.orthodb.org/?gene=G3MZN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21740:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21740:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T2H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2H3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B808", "url": "https://www.uniprot.org/uniprotkb/E1B808", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B808-1", "url": "https://www.uniprot.org/uniprotkb/E1B808-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZN5", "url": "https://www.uniprot.org/uniprotkb/G3MZN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZN5-1", "url": "https://www.uniprot.org/uniprotkb/G3MZN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLESRAIPKNPGQGFSWAPGGAEHRSCKVTILAACVSVPAWVRRQRQPAGASLTYPQGLMSEAMDQSAGSPGNLNPGEGGDGSTEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAGSLPQIPLAPLQPPSEPPASPSLSSAEGPATPLPLGRCAGQREVCWEQQLRSGGPGPPATPPPALDALSPFLQKKAQILEVLRALEETDPLLLCSPATPWQPPGEGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGGLLHWERFLGAPGEEEGAGRPWGPGRGSPQAQGTGSGPPCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTESYLQAFLAGAACPLSGDHPGPRQPSSPDQGPPQLSKSKGLPKSAWVGGTPEANRPGFGATSEGQGSLPFLSMFMGAGDTPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCSMTPDSAQLRPPQPALSATLSPGPTVSPCYENILDLSRNTFRGPSPEPPPSPLQVPTYPQLTLEVPRVPEVLRSPGIPSSPCHPESCPYEGTQEKSSDKAGSESPHPGRRGPGSSSKKPSQGAGRRPGDPGYTPLRDRLAALGKLKTGPEGSQGPEKNGVPVKPGTEKARGAGKLGESTGDTAPPASRPPEQPEAKGALRGAVALGTSSLKQQESGLLGDPGARVYSSHSMGARVDLEPLSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPVVPPATKEPPKPDKGKGPPWADCGGTMAQPMSPAPGAADPGPGPEGRAPHSAIEEKVMKGIEENMLRLQGQERAPGTEAKHRNTSSIASWFGLKKSKLPALNRRTETTKGKEGAGGSPLRKEVKVEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGTSAGLGQGQGQLVGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSSDPKNPWPACGPRNGLVGPLQGCGKPGKPSIEPGRREEMPSEDSLAEPVTTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLEPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAAPGHRGHQTCPDGECLGRGRVGLSGSSAHHPPSPCPRTDPCEDPGPPPPVQLAKNWTFPNARAAGGSSDPFLCPPRQLEGLPRTPMALPVDGKRSLEPTRPAPAPQGPAFGCSRTPSTSDVGEEGRVASGGPPGLETSESLSDSLYDSLSSCGSQG", "length": 1417, "header": "tr|E1B808-1|E1B808_BOVIN Isoform 1 of NCK associated protein 5 like OS=Bos taurus OX=9913 GN=NCKAP5L PE=4 SV=4 CANONICAL=E1B808-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2H3/entry", "sequence": { "sequence": "MSEAMDQSAGSPGNLNPGEGGDGSTEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAGSLPQIPLAPLQPPSEPPASPSLSSAEGPATPLPLGRCAGQREVCWEQQLRSGGPGPPATPPPALDALSPFLQKKAQILEVLRALEETDPLLLCSPATPWQPPGEGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGGLLHWERFLGAPGEEEGAGRPWGPGRGSPQAQGTGSGPPCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTESYLQAFLAGAACPLSGDHPGPRQPSSPDQGPPQLSKSKGLPKSAWVGGTPEANRPGFGATSEGQGSLPFLSMFMGAGDTPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCSMTPDSAQLRPPQPALSATLSPGPTVSPCYENILDLSRNTFRGPSPEPPPSPLQVPTYPQLTLEVPRVPEVLRSPGIPSSPCHPESCPYEGTQEKSSDKAGSESPHPGRRGPGSSSKKPSQGAGRRPGDPGYTPLRDRLAALGKLKTGPEGSQGPEKNGVPVKPGTEKARGAGKLGESTGDTAPPASRPPEQPEAKGALRGAVALGTSSLKQQESGLLGDPGARVYSSHSMGARVDLEPLSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPVVPPATKEPPKPDKGKGPPWADCGGTMAQPMSPAPGAADPGPGPEGRAPHSAIEEKVMKGIEENMLRLQGQERAPGTEAKHRNTSSIASWFGLKKSKLPALNRRTETTKGKEGAGGSPLRKEVKVEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGTSAGLGQGQGQLVGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSSDPKNPWPACGPRNGLVGPLQGCGKPGKPSIEPGRREEMPSEDSLAEPVTTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLEPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAAPGHRGHQTCPDDPCEDPGPPPPVQLAKNWTFPNARAAGGSSDPFLCPPRQLEGLPRTPMGTWV", "length": 1266, "header": "tr|A0AAA9T2H3-1|E1B808_BOVIN Computationally mapped isoform of NCK associated protein 5 like OS=Bos taurus OX=9913 GN=NCKAP5L PE=4 SV=1 CANONICAL=E1B808-1" }, "locus": { "chromosome": "5", "start_pos": 30097014, "end_pos": 30081826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093995.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093995.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090834.1" } ] } }, { "isoform_ac": "A0AAA9TNT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNT9/entry", "sequence": { "sequence": "MSEAMDQSAGSPGNLNPGEGGDGSTEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAGSLPQIPLAPLQPPSEPPASPSLSSAEGPATPLPLGRCAGQREVCWEQQLRSGGPGPPATPPPALDALSPFLQKKAQILEVLRALEETDPLLLCSPATPWQPPGEGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGGLLHWERFLGAPGEEEGAGRPWGPGRGSPQAQGTGSGPPCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTESYLQAFLAGAACPLSGDHPGPRQPSSPDQGPPQLSKSKGLPKSAWVGGTPEANRPGFGATSEGQGSLPFLSMFMGAGDTPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCSMTPDSAQLRPPQPALSATLSPGPTVSPCYENILDLSRNTFRGPSPEPPPSPLQVPTYPQLTLEVPRVPEVLRSPGIPSSPCHPESCPYEGTQEKSSDKAGSESPHPGRRGPGSSSKKPSQGAGRRPGDPGYTPLRDRLAALGKLKTGPEGSQGPEKNGVPVKPGTEKARGAGKLGESTGDTAPPASRPPEQPEAKGALRGAVALGTSSLKQQESGLLGDPGARVYSSHSMGARVDLEPLSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPVVPPATKEPPKPDKGKGPPWADCGGTMAQPMSPAPGAADPGPGPEGRAPHSAIEEKVMKGIEENMLRLQGQERAPGTEAKHRNTSSIASWFGLKKSKLPALNRRTETTKGKEGAGGSPLRKEVKVEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGTSAGLGQGQGQLVGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSSDPKNPWPACGPRNGLVGPLQGCGKPGKPSIEPGRREEMPSEDSLAEPVTTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLEPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAAPGHRGHQTCPDGECLGRGRVGLSGSSAHHPPSPCPRTDPCEDPGPPPPVQLAKNWTFPNARAAGGSSDPFLCPPRQLEGLPRTPMVSMAEGEREQHWRAAGNDEG", "length": 1308, "header": "tr|A0AAA9TNT9-1|E1B808_BOVIN Computationally mapped isoform of NCK associated protein 5 like OS=Bos taurus OX=9913 GN=NCKAP5L PE=4 SV=1 CANONICAL=E1B808-1" }, "locus": { "chromosome": "5", "start_pos": 30092699, "end_pos": 30081826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090390.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090390.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100236.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100236.1" } ] } }, { "isoform_ac": "E1B808-1", "url": "https://www.uniprot.org/uniprotkb/E1B808/entry", "sequence": { "sequence": "MLESRAIPKNPGQGFSWAPGGAEHRSCKVTILAACVSVPAWVRRQRQPAGASLTYPQGLMSEAMDQSAGSPGNLNPGEGGDGSTEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAGSLPQIPLAPLQPPSEPPASPSLSSAEGPATPLPLGRCAGQREVCWEQQLRSGGPGPPATPPPALDALSPFLQKKAQILEVLRALEETDPLLLCSPATPWQPPGEGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGGLLHWERFLGAPGEEEGAGRPWGPGRGSPQAQGTGSGPPCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTESYLQAFLAGAACPLSGDHPGPRQPSSPDQGPPQLSKSKGLPKSAWVGGTPEANRPGFGATSEGQGSLPFLSMFMGAGDTPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCSMTPDSAQLRPPQPALSATLSPGPTVSPCYENILDLSRNTFRGPSPEPPPSPLQVPTYPQLTLEVPRVPEVLRSPGIPSSPCHPESCPYEGTQEKSSDKAGSESPHPGRRGPGSSSKKPSQGAGRRPGDPGYTPLRDRLAALGKLKTGPEGSQGPEKNGVPVKPGTEKARGAGKLGESTGDTAPPASRPPEQPEAKGALRGAVALGTSSLKQQESGLLGDPGARVYSSHSMGARVDLEPLSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPVVPPATKEPPKPDKGKGPPWADCGGTMAQPMSPAPGAADPGPGPEGRAPHSAIEEKVMKGIEENMLRLQGQERAPGTEAKHRNTSSIASWFGLKKSKLPALNRRTETTKGKEGAGGSPLRKEVKVEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGTSAGLGQGQGQLVGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSSDPKNPWPACGPRNGLVGPLQGCGKPGKPSIEPGRREEMPSEDSLAEPVTTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLEPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAAPGHRGHQTCPDGECLGRGRVGLSGSSAHHPPSPCPRTDPCEDPGPPPPVQLAKNWTFPNARAAGGSSDPFLCPPRQLEGLPRTPMALPVDGKRSLEPTRPAPAPQGPAFGCSRTPSTSDVGEEGRVASGGPPGLETSESLSDSLYDSLSSCGSQG", "length": 1417, "header": "tr|E1B808-1|E1B808_BOVIN Isoform 1 of NCK associated protein 5 like OS=Bos taurus OX=9913 GN=NCKAP5L PE=4 SV=4 CANONICAL=E1B808-1" }, "locus": { "chromosome": "5", "start_pos": 30093158, "end_pos": 30077858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006377.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006377.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006377.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006377.7" } ] } }, { "isoform_ac": "G3MZN5-1", "url": "https://www.uniprot.org/uniprotkb/G3MZN5/entry", "sequence": { "sequence": "MLESRAIPKNPGQGFSWAPGGAEHRSCKVTILAACVSVPAWVRRQRQPAGASLTYPQGLMSEAMDQSAGSPGNLNPGEGGDGSTEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAGSLPQIPLAPLQPPSEPPASPSLSSAEGPATPLPLGRCAGQREVCWEQQLRSGGPGPPATPPPALDALSPFLQKKAQILEVLRALEETDPLLLCSPATPWQPPGEGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGGLLHWERFLGAPGEEEGAGRPWGPGRGSPQAQGTGSGPPCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTESYLQAFLAGAACPLSGDHPGPRQPSSPDQGPPQLSKSKGLPKSAWVGGTPEANRPGFGATSEGQGSLPFLSMFMGAGDTPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCSMTPDSAQLRPPQPALSATLSPGPTVSPCYENILDLSRNTFRGPSPEPPPSPLQVPTYPQLTLEVPRVPEVLRSPGIPSSPCHPESCPYEGTQEKSSDKAGSESPHPGRRGPGSSSKKPSQGAGRRPGDPGYTPLRDRLAALGKLKTGPEGSQGPEKNGVPVKPGTEKARGAGKLGESTGDTAPPASRPPEQPEAKGALRGAVALGTSSLKQQESGLLGDPGARVYSSHSMGARVDLEPLSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPVVPPATKEPPKPDKGKGPPWADCGGTMAQPMSPAPGAADPGPGPEGRAPHSAIEEKVMKGIEENMLRLQGQERAPGTEAKHRNTSSIASWFGLKKSKLPALNRRTETTKGKEGAGGSPLRKEVKVEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGTSAGLGQGQGQLVGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSSDPKNPWPACGPRNGLVGPLQGCGKPGKPSIEPGRREEMPSEDSLAEPVTTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLEPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAAPGHRGHQTCPDDPCEDPGPPPPVQLAKNWTFPNARAAGGSSDPFLCPPRQLEGLPRTPMALPVDGKRSLEPTRPAPAPQGPAFGCSRTPSTSDVGEEGRVASGGPPGLETSESLSDSLYDSLSSCGSQG", "length": 1391, "header": "tr|G3MZN5-1|E1B808_BOVIN Computationally mapped isoform of NCK associated protein 5 like OS=Bos taurus OX=9913 GN=NCKAP5L PE=4 SV=3 CANONICAL=E1B808-1" }, "locus": { "chromosome": "5", "start_pos": 30093158, "end_pos": 30077858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064875.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064875.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055036.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055036.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" }, { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "reported site T1137 is on non-canonical isoform A0AAA9T2H3-1 which maps to canonical isoform site E1B808-1:1196", "icn3d_view": {}, "start_pos": 1196, "start_aa": "Thr", "end_pos": 1196, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1196", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" }, { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "reported site T172 is on non-canonical isoform A0AAA9T2H3-1 which maps to canonical isoform site E1B808-1:231", "icn3d_view": {}, "start_pos": 231, "start_aa": "Thr", "end_pos": 231, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr231", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" }, { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "reported site T385 is on non-canonical isoform A0AAA9T2H3-1 which maps to canonical isoform site E1B808-1:444", "icn3d_view": {}, "start_pos": 444, "start_aa": "Thr", "end_pos": 444, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr444", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" }, { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "reported site T551 is on non-canonical isoform A0AAA9T2H3-1 which maps to canonical isoform site E1B808-1:610", "icn3d_view": {}, "start_pos": 610, "start_aa": "Thr", "end_pos": 610, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr610", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504364", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504364", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K5W1-1", "protein_name": "NCK-associated protein 5-like", "gene_name": "Nckap5l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSLDWLSGRREAGSGRGAGLIGPFKALTSRGGSGTPLFLPPPTPARPRDAAMDPADQASRTQHLISPARSCSQTLTPKAMDQPAGGTGNLRPASGEDSSMELGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSTLLQQKLQLTTSSLPQIPLTPLQPPSERPASPSPNAAEGPATTLPLGHCAGPREVCWEQQLRPGGPGPPATPPPALDALSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPTGQGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGALLHWERALGGPGEEEGIRQPWASSRAPLPAQGPGAGPHCAPGSSSSSSSDEAGDPNEAPSPDTLLGVLARKQLNLGQLLGDTEISLPAFLAGATGPLSGDHPHPSAGKLSSPDPGAPQVSKSKGLPKSAWGGSAPEASRLGFGATSEGQGPLPFLSMFMGAGDAPLGSRPGHSHSSSQVKSKLQIGLPSPGDAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRSSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPSSPLPCSANPDSAQLRTSQSAVSTTLSAGPVVSPCFENILDLSRGTFRGSSTEPPPSPLQVPTYPQLTLEVPQTHEVLRSPGAPSPGLPGPCPYSSPQEKSVDRAGSESPHLSRRTPCGSSKKPGQGSGRRPGDPSHTPLRDRLAALGKLKTGPEGPLGPEKNGVPARSNTEKAKAPVRSGECPGDVSPSTRPLEQPEAKGIFRGAVALGTSSLKQQEPGLTDLGARVYSSHSMGARVDLEPISPRSCLTKVELAKSRLAGALCPQMPRTPAKVPTSAPSLGKPKSPHSSPTKLPSKSPTKVVPRPVAPLGTKEPPKPDKVKGPPWADCGTTVGQPTSPVPGPVDQSPGPEGPVPHSAIEEKVMKGIEENVLRLQGQERTPGSEAKHRNASSIASWFGLKKSKLPALNRRTEAAKNKEGAGGGSPLRKEVKTEAWKLEAESLNISKLMAKAEDLRRALEEEKAYLSRARPRPGGPATVPSPSVGQPQGQLTGMYQGADTFMQQLLNRVDGKDLPPESWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPLQGCGKPGKPISEPGRREAMPPEDNLAEPVSTAHFTACGSLTRTLDSGIGTFPPPDHSSSGTPSKNLPKTKSFRLDPPPGAPAARPPGLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAPPGHRSHQTCPDDPCEDPGPPPPVQLAKNWTFPNTRTSGSTSDPFLCPPRQLEGLPRTAMALPVDRKQSLDPSRTSMPQGPAFGGSRTPSTSDMGEEGRVASGGAPGLETSESLSDSLYDSLSSCGSQG", "length": 1405 }, "evidence": [ { "id": "E1B808", "url": "https://omabrowser.org/oma/group/E1B808/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A480HN51-1", "protein_name": "NCK associated protein 5 like", "gene_name": "NCKAP5L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSEAMDQPAESPGNPKPGEGGDDSMEPGTCQELLHRLRELEAENTALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAGSLPQIPLAPLQPPSEPPASPSLSSAEGPATSLPLGRCAGQREVCWEQQLRPGGPGPPAAPPPALDALSPFLRKKAQILEVLRALEETDPLLLCSPATPWQPTGEGPGSPEPINGELCGPPQPEPSPWAPYLLLGPGSLGGLLHWERLLGGPGEEEGAGRSWGPGRGSLQAQGTGSGPPCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTESYLQAFLAGAACPLSGDHPAPRQPSSPDPGPPQLSKSKGLPKSAWAGGTPEAHRPGFGATSEGQGPLPFLSVFMGAGDAPLGARPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGPQGLPTSPSPCVTTPDSAQLRPPQPALPTALSPGPVVSPCYENILDLSRSPFRGPSPEPPPSPLQVPTYPQLTLEVPRAPEVLRSPGVPSSPCLPESCPYESTQEKSLDKAGSESPHPGRRPPGGSSKKPGQGAGRRPGDPGFTPLRDRLAALGKLKTGPEGPQGPEKNGVQTRPGTEKARGAGRSGESPGDMVPPASRPPEPPEVKGALRGAVASGTSSLKQQEPGLLGDPGARVYSSHSMGGRVDLEPISPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHGSPTKLPSKSPTKVAPRPVGPPATKEAPKADKGKGPPWADCGGTVAQPAPPAPGPADPSPGPEGRPPHSAIEEKVMKGIEENVLRLQGQERAPSTEAKHRNTSSIASWFGLKKSKLPALNRRTEATKGKEGASGGSPLRKEVKVEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPVPGPTAGLGQVQGQLAGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVASDPKNPWPACGPRNGLVGPLQGCGKPPGKPSSEPGRREEMPSEDNLTEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLEPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLTAAPGHRGHQTCPDDPCEDPGPPPPVQLAKNWTFPNARAAGGSSDPFLCPPRPLEGLPRTPMALPVDRKQNLEPSRPAPALQGPAFGGSRTPSTSDVGEEGRVASGGPPGLETSESLSDSLYDSLSSCGSQG", "length": 1334 }, "evidence": [ { "id": "E1B808", "url": "https://omabrowser.org/oma/group/E1B808/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6GQX2-1", "protein_name": "Nck-associated protein 5-like", "gene_name": "Nckap5l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQPAGGTGKLRASAGEDDSMELSTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQVLSALLQQKLQLTANSLPQIPLTPLQPPSERPTSPAPNVSEGPATSLPSGLCAGQREVCWEQQLRPGGPGPPATPPPALDALSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPTGQGPGSPEPINGEPCGPPQPEPSPWAPYLLLGPGSLGALLHWERVLGGPGEEEGIRQPWASSRAPPSAQGPSSGPHCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLGDTETYLQAFLAGATGPLSGDQPGPGKPNSPDPGPPQVSKSKGLPKSAWGASTPEATRLGFGATSEGQGPLPFLSMFMGAGDAPLGSRPGHPHSSSQVKSKLQIGPPSPGDAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLSPQLPRSSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPGSPLPCSAMPDSAQLRPSQSTVSTALSPGPVVSPCFENILDLSRSTFRGSPPEPPPSPLQVPTYPQLTLEVPQTPEVLRSPGAPSPGLPESCPYSGPQEKSMDRAGSESPHASRRTPGGSSKKPGQGSGRRPGDPSHTPLRDRLAALGKLKTGPEGPLGPEKNGVPARSSAEKARALVRSGECAGDVPPSARPLEQPEAKGIFRGAVALGTSSLKQQEPGLTDPGARVYSSHSMGARVDLEPISPRSCLTKVELAKSRLAGALCPQMPRTPAKVPTSAPSLGKPKSPHSSPTKLPSKSPTKVVPRPVVPLGTKEPPKPDKVKGPPWADCGSTVGQPTSPVAGPADPSQGSEGPAPHSAIEEKVMKGIEENVLRLQGQERTPGSEAKHRNTSSIASWFGLKKSKLPALNRRTEATKNKDGAGGGSPLRKEVKTEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSRARPRPGGPATVPSPGLGQAQGQLAGMYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSTDPKSPWPACGPRNGLVGPLQGCGKPGKPSSEPGRREEMPSEDSLAEPVSTTHFTACGSLTRTLDSGIGTFPPPDHSSSGTPSKNLPKTKSLRLDPPPGAPPARPPGLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPGLLTAPPGHRSHQTCPDDPCEDPGPPPPVQLAKNWTFPNTRTAGSSSDPFLCPPRQLEGLPRTPMALPVDRKQSVDPSRTSTPQGPAFGGSRTPSTSDMGEEGRVASGGAPGLETSESLSDSLYDSLSSCGSQG", "length": 1323 }, "evidence": [ { "id": "E1B808", "url": "https://omabrowser.org/oma/group/E1B808/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HCH0-1", "protein_name": "Nck-associated protein 5-like", "gene_name": "NCKAP5L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEAMDQPAGGPGNPRPGEGDDGSMEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTTGSLPQIPLTPLQPPSEPPASPSLSSTEGPAAPLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDALSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPPGQGPGSPEPINGELCGPPQPEPSPWAPCLLLGPGNLGGLLHWERLLGGLGGEEDTGRPWGPSRGPPQAQGTSSGPNCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESYLQAFLAGAAGPLNGDHPGPGQSSSPDQAPPQLSKSKGLPKSAWGGGTPEAHRPGFGATSEGQGPLPFLSMFMGAGDAPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPTSEKSPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCYTTPDSTQLRPPQSALSTTLSPGPVVSPCYENILDLSRSTFRGPSPEPPPSPLQVPTYPQLTLEVPQAPEVLRSPGVPPSPCLPESYPYGSPQEKSLDKAGSESPHPGRRTPGNSSKKPSQGSGRRPGDPGSTPLRDRLAALGKLKTGPEGALGSEKNGVPARPGTEKTRGPGKSGESAGDMVPSIHRPLEQLEAKGGIRGAVALGTNSLKQQEPGLMGDPGARVYSSHSMGARVDLEPVSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPGAPLVTKESPKPDKGKGPPWADCGSTTAQSTPLVPGPTDPSQGPEGLAPHSAIEEKVMKGIEENVLRLQGQERAPGAEVKHRNTSSIASWFGLKKSKLPALNRRTEATKNKEGAGGGSPLRREVKMEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGPNTGLGQVQGQLAGMYQGADTFMQQLLNRVDGKELPSKSWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPLQGCGKPPGKPSSEPGRREEMPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLDPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLPAAPGHRGHETCPDDPCEDPGPTPPVQLAKNWTFPNTRAAGSSSDPLMCPPRQLEGLPRTPMALPVDRKRSQEPSRPSPTPQGPPFGGSRTPSTSDMAEEGRVASGGPPGLETSESLSDSLYDSLSSCGSQG", "length": 1334 }, "evidence": [ { "id": "E1B808", "url": "https://omabrowser.org/oma/group/E1B808/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1B808", "url": "https://www.uniprot.org/uniprotkb/E1B808" } ], "pmid": "" }, { "name": "microtubule plus-end", "id": "GO:0035371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035371", "evidence": [ { "database": "UniProtKB", "id": "E1B808", "url": "https://www.uniprot.org/uniprotkb/E1B808" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule depolymerization", "id": "GO:0007019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007019", "evidence": [ { "database": "UniProtKB", "id": "E1B808", "url": "https://www.uniprot.org/uniprotkb/E1B808" } ], "pmid": "" }, { "name": "microtubule bundle formation", "id": "GO:0001578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001578", "evidence": [ { "database": "UniProtKB", "id": "E1B808", "url": "https://www.uniprot.org/uniprotkb/E1B808" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1025, "end_pos": 1027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1316, "end_pos": 1318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 867, "end_pos": 869, "annotation": "n_glycosylation_sequon" }, { "start_pos": 972, "end_pos": 974, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B808" }, { "id": "PF15246", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15246" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nck-associated protein 5 C-terminal", "eco_id": "ECO_0000259", "start_pos": 939, "end_pos": 1238, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 231, 444, 610, 1196 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1025, "end_pos": 1027 }, { "start_pos": 1316, "end_pos": 1318 }, { "start_pos": 867, "end_pos": 869 }, { "start_pos": 972, "end_pos": 974 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9H2-1", "uniprot_ac": "E1B9H2", "uniprot_id": "E1B9H2_BOVIN", "mass": { "chemical_mass": 154651.0, "monoisotopic_mass": 154651.0 }, "refseq": { "ac": "XP_024849433", "name": "uncharacterized protein KIAA0232 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849433" }, "gene_names": [ { "name": "KIAA0232", "type": "recommended", "evidence": [ { "id": "E1B9H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H2" } ] }, { "name": "KIAA0232", "type": "synonym", "evidence": [ { "id": "XP_024849433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849433" } ] } ], "protein_names": [ { "name": "KIAA0232", "type": "synonym", "evidence": [ { "id": "E1B9H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H2/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein KIAA0232 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024849433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849433" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9H2", "url": "https://www.uniprot.org/uniprotkb/E1B9H2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA0232", "url": "https://www.uniprot.org/uniprotkb/E1B9H2", "locus": { "chromosome": "6", "start_pos": 113373307, "end_pos": 113323689, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019427", "url": "https://www.ensembl.org/id/ENSBTAG00000019427" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019427", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019427", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514704", "url": "https://www.ncbi.nlm.nih.gov/gene/514704", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514704", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514704", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EWALVPP", "url": "https://omabrowser.org/oma/group/EWALVPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9H2", "url": "https://www.orthodb.org/?gene=E1B9H2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17611", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17611", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17611:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17611:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15376", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15376", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024849433", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849433", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9H2", "url": "https://www.uniprot.org/uniprotkb/E1B9H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9H2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9H2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPVCAVAVDDLPSESSSSSYPGPVSVSEMSLLHALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQENDIFLGWEKGAYKKWGKSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCSRLKDLQSQQEEKIHKKLEGSPSPEAELSPTAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSAVGSYSSSSSSSTAPPASTDTPSPKDCNSEGEIIRERSGDAPPASLHERTQSGRSHSEKENRFRNGPSEERSAPPPPSKKQSRHRPDGKPRPRSWSSGSSEAGSSSSGNQGEPKASAKCVKLRHKVREIRNKKGARSGQSRLSLKRGEKAERSPHAAGSSSSSGGGGSFRQLCKRGKRPLKELGRKEAGGAEGRDLFLESRTDREYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNRQDAGDVTSAAVEELSESVHGLCISNNNIHKTYLAAGTFIDGHFVEMPAVINEDIDLAGTSFCPLPEDDKYLDDIHLSELTHFYEVDIDQSMLDPGASETTQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWADCTSSVGAEGFLLQDLGSLAQFWECCSSSSGDADGESFAGDSPVRLSPTLDSTALNPHLLAGNQELFSDINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGNENTDSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEETRSDNETLSVQFEESTQFNAEDINYVVPRVSSNYVDEELLDFLQDETCQQNSRTLGEIPTLVFQKKSKLESICGIQLEQKAENKAFETTQACSEGSPRGDGYSSGVIKDIWTKMADRNSAAPLEIESVDDELFPTDVNNYCCCLDAEAPMEPLQEPNKAVQRSEYHLWEGQKETLEKRAFVSGELSKVDGGDYTTPSKPWDVTQDKGSSFILGGVYGELRTLNSDAGWAVVPPSHAKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSLEQNDQPKSGENGLNKGFSFIFHEDLLGACGNFQVEDPGLEYPFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICDVDRTQYRAIRISPRTHFRPISASELSPGGGSESEFESERDEANVPIPSQVDAFEDPQADLKPLEEDAEKEGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQEESAGVLPAGERNPCLECSMSEPLEIDLESPEANCKIMAQCEEEINHFCSCKAGCQFPAYEDNPVSSGQLEEQFPVLNTDVHGMNRSQERQTWWEKALYSPLFPASECEECYTNAKGENGIEEYPDVKEMPSNEERLLDFNRVSSVYEAKCTAEQDAGAQPNGFHRTPRCSAGSAAEDSGSEGGGEWADPGAEALFSRTHL", "length": 1405, "header": "tr|E1B9H2-1|E1B9H2_BOVIN Isoform 1 of KIAA0232 OS=Bos taurus OX=9913 GN=KIAA0232 PE=4 SV=3 CANONICAL=E1B9H2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L3/entry", "sequence": { "sequence": "MRPVCAVAVDDLPSESSSSSYPGPVSVSEMSLLHALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQENDIFLGWEKGAYKKWGKSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCSRLKDLQSQQEEKIHKKLEGSPSPEAELSPTAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSAVGSYSSSSSSSTAPPASTDTPSPKDCNSEGEIIRERSGDAPPASLHERTQSGRSHSEKENRFRNGPSEERSAPPPPSKKQSRHRPDGKPRPRSWSSGSSEAGSSSSGNQGEPKASAKCVKLRHKVREIRNKKGARSGQSRLSLKRGEKAERSPHAAGSSSSSGGGGSFRQLCKRGKRPLKELGRKEAGGAEGRDLFLESRTDREYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNRQDAGDVTSAAVEELSESVHGLCISNNNIHKTYLAAGTFIDGHFVEMPAVINEDIDLAGTSFCPLPEDDKYLDDIHLSELTHFYEVDIDQSMLDPGASETTQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWADCTSSVGAEGFLLQDLGSLAQFWECCSSSSGDADGESFAGDSPVRLSPTLDSTALNPHLLAGNQELFSDINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGNENTDSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEETRSDNETLSVQFEESTQFNAEDINYVVPRVSSNYVDEELLDFLQDETCQQNSRTLGEIPTLVFQKKSKLESICGIQLEQKAENKAFETTQACSEGSPRGDGYSSGVIKDIWTKMADRNSAAPLEIESVDDELFPTDVNNYCCCLDAEAPMEPLQEPNKAVQRSEYHLWEGQKETLEKRAFVSGELSKVDGGDYTTPSKPWDVTQDKGSSFILGGVYGELRTLNSDAGWAVVPPSHAKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSLEQNDQPKSGENGLNKGFSFIFHEDLLGACGNFQVEDPGLEYPFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICDVDRTQYRAIRISPRTHFRPISASELSPGGGSESEFESERDEANVPIPSQVDAFEDPQADLKPLEEDAEKEGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQEESAGVLPAGERNPCLECSMSEPLEIDLESPEANCKIMAQCEEEINHFCSCKAGCQFPAYEDNPVSSGQLEEQFPVLNTDVHGMNRSQERQTWWEKALYSPLFPASECEGVFCL", "length": 1318, "header": "tr|A0AAA9T2L3-1|E1B9H2_BOVIN Computationally mapped isoform of KIAA0232 OS=Bos taurus OX=9913 GN=KIAA0232 PE=4 SV=1 CANONICAL=E1B9H2-1" }, "locus": { "chromosome": "6", "start_pos": 113372140, "end_pos": 113323888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108180.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108180.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090683.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090683.1" } ] } }, { "isoform_ac": "E1B9H2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9H2/entry", "sequence": { "sequence": "MRPVCAVAVDDLPSESSSSSYPGPVSVSEMSLLHALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQENDIFLGWEKGAYKKWGKSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCSRLKDLQSQQEEKIHKKLEGSPSPEAELSPTAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSAVGSYSSSSSSSTAPPASTDTPSPKDCNSEGEIIRERSGDAPPASLHERTQSGRSHSEKENRFRNGPSEERSAPPPPSKKQSRHRPDGKPRPRSWSSGSSEAGSSSSGNQGEPKASAKCVKLRHKVREIRNKKGARSGQSRLSLKRGEKAERSPHAAGSSSSSGGGGSFRQLCKRGKRPLKELGRKEAGGAEGRDLFLESRTDREYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNRQDAGDVTSAAVEELSESVHGLCISNNNIHKTYLAAGTFIDGHFVEMPAVINEDIDLAGTSFCPLPEDDKYLDDIHLSELTHFYEVDIDQSMLDPGASETTQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWADCTSSVGAEGFLLQDLGSLAQFWECCSSSSGDADGESFAGDSPVRLSPTLDSTALNPHLLAGNQELFSDINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGNENTDSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEETRSDNETLSVQFEESTQFNAEDINYVVPRVSSNYVDEELLDFLQDETCQQNSRTLGEIPTLVFQKKSKLESICGIQLEQKAENKAFETTQACSEGSPRGDGYSSGVIKDIWTKMADRNSAAPLEIESVDDELFPTDVNNYCCCLDAEAPMEPLQEPNKAVQRSEYHLWEGQKETLEKRAFVSGELSKVDGGDYTTPSKPWDVTQDKGSSFILGGVYGELRTLNSDAGWAVVPPSHAKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSLEQNDQPKSGENGLNKGFSFIFHEDLLGACGNFQVEDPGLEYPFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICDVDRTQYRAIRISPRTHFRPISASELSPGGGSESEFESERDEANVPIPSQVDAFEDPQADLKPLEEDAEKEGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQEESAGVLPAGERNPCLECSMSEPLEIDLESPEANCKIMAQCEEEINHFCSCKAGCQFPAYEDNPVSSGQLEEQFPVLNTDVHGMNRSQERQTWWEKALYSPLFPASECEECYTNAKGENGIEEYPDVKEMPSNEERLLDFNRVSSVYEAKCTAEQDAGAQPNGFHRTPRCSAGSAAEDSGSEGGGEWADPGAEALFSRTHL", "length": 1405, "header": "tr|E1B9H2-1|E1B9H2_BOVIN Isoform 1 of KIAA0232 OS=Bos taurus OX=9913 GN=KIAA0232 PE=4 SV=3 CANONICAL=E1B9H2-1" }, "locus": { "chromosome": "6", "start_pos": 113372303, "end_pos": 113323888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025878.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025878.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025878.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025878.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514704", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514704", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7EYH7-1", "protein_name": "Uncharacterized protein KIAA0232 homolog isoform X1", "gene_name": "Kiaa0232", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MCPVSTVVVDGLPSESTSSSYPGPVSVSDMSLLHALGPVQTWLGQELEKCGIDAMIYSRYILSLLLHDSYDYDLQEQENDILGWEKGAYKKWGRSKKKSSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCCRLKDLQSEQEEKIHKKLEGSPSPEAELSPTAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSKPCSHSSSSSSSTAPPASTDTSSPKDCNSESEAIRERSTAASIPIHEKAQSRSRHEKENKLSNGTIEEKPALYKKQIRHKPEGKIRPRSWSSGSSEAGSSSSGNQGELKASMKYVKVRHKAREIRNKKGRNGQSRLSLKHCEKAERSVHAGSSSSSSSSGSIRQLCKRGKRPAKETGRSDPGNTAVKDLYVESRNNKEYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNREDTSALTAEAVEDLSESVHGLCISNSNIHRTYLAAGTFIDGHFVEMPAVINEDIDLAGTSLCSLPEDNKYLDDIHLSELTHFYEVDIDQSMLDPGASETMQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWTDSTSSVGAEGFFLQDLGNLAQFWECCSSSSGDADGESFGGDSPVRLSPILDSTILSSHVLAGNQEPFSNINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGSEPTDSSANILGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEEARSDNETLNIQFEESTQFTAEDINYVVPRVSSDYVDEELLDFLQDEACQQNSRTLGEIPTLVFKKRSKLESVCGIQLEQKAENKNFETTQACSESSPHGDGYSSGVIKDIWTKMADRNSVAAVETERTGEELFSTDVNNYCCCLDTDAKIEALQEPSRAVQRSEYHLWEGQKENLEKRAFISSELSKVDGGDYTTPSKPWDVAQDKENTFILGGVYGELKTFNSDGEWAVVPPGHTKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSFEQNDMPKSGENGLNKGFSFIFHEDLLGACSNFQVEDPGLEYSFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICGVDRTQYRAIRISPRTHFRPISASELSPGGGSESEFESERDEANIPIPSQIDVFEDPQADLKPLEEDAEKEGHYYGKLELESGKFLPRLKKSGMEKSAQTSLDSQEEATGILPVGKQNQCLECNFNESLEINLESSAVNCKIMAQCEEEINDFCSCKAGCQFPACEDNPVSSGQLEEIGKKENEERSKIPPTTTIFLRFLFPVLNTDVQEVTRDQEKQSWWEKALYSPLFPSSECEGSVASHGSYTRRQLATHLLKGPGIPEGPSIRNECYTNAKGENGIEEYPDAKETPSREERLLDFNRVSSVYEARCTGERGSEAKPNGLHRKMCSSASSDTGDTGSEAGGEWVGPNTEELFSRTHL", "length": 1451 }, "evidence": [ { "id": "E1B9H2", "url": "https://omabrowser.org/oma/group/E1B9H2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZYT3-1", "protein_name": "KIAA0232 homolog", "gene_name": "Kiaa0232", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPVCTVVVDGLPSESTSSSYPGPVSVSDMSLLHALGPVQTWLGQELEKCGIDAMIYSRYILSLLLHDSYDYDLQEQENDILGWEKGAYKKWGRSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCCRLKDLQSEQEEKIHKKLEGSPSPEAELSPTAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSKPCSYSSSSSSSTVPPASTDPSSPKDCNSESEAVRERSSAASILTHEKAQSRSRHEENKLSHSTIEEKPALYKKQIRHKPEGKIRPRSWSSGSSEAGSSSSGNQGELKASMKYVKVRHKAREIRNKKGRNGQSRQSLKHCGKAERGVHAGSSSSSSSSSSSNGSIRQLCKRGKRPAKETGRSDSGNTAVKDLYVESRSNKEYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNREDTSALTAEAVEDLSDSVRGLCISNSNIHRTYLAAGTFIDGHFVEMPAVINEDIDLAGTSLCSLPEDNKYLDDIHLSELTHFYEVDIDQSMLDPGASETMQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWTDSTSPVGAEGFFLQDLGNLAQFWECCSSSSGDADGESFGGDSPVRLSPILDSTILSSHMLAGNQEPFSNINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGSEHTDSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEEARSDNETLNLQFEESTQFTAEDINYVVPRVSSDFVDEELLDFLQDETCQQNSRTLGEIPTLVFKKRSKLESVCGIQLEQKAESKNFETTQACGESSPHGDGYSSGVIKDIWTKMVGRSSVAAAETERAGEELFSTDVSNYCCCLDTEAKMETLQEPSRAVQRSEYHLWEGQKENVEKRAFVSSELSKVDGGDYTTPSKPWDVAQDKENTFILGGVYGELKTFNSDGEWAVVPPGHTKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSFEQNDMPKSGENGLNKGFSFIFHEDLLGACSNFQVEDPGLEYSFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICGVDRTQYRAIRISPRTHFRPISASELSPAGGSESEFESEKDEANIPIPSQVDVFEDPQADLKPLEEDAEKEGHYYGKLELESGKFLPRLKKSGMEKSAQTSLDSQEEAAGILPVGKQSQCLECNFNESLGINLESSTANCKIMTQCEEEMNGFCSCKAGCQFPACEDNPVSSGQLEEFPVLNTDVQEVTRNQEKQSWWEKALYSPLFPTSECEECYTNAKGENGIEEYPDAKETPSREERLLDFNRVSSVYEARCTGERGSETKPNGLPGKMCSSASSDAGDTGSEAGGEWVGPSREDLFSRTHL", "length": 1399 }, "evidence": [ { "id": "E1B9H2", "url": "https://omabrowser.org/oma/group/E1B9H2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QJT2-1", "protein_name": "Uncharacterized protein KIAA0232 homolog", "gene_name": "kiaa0232", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRPMSGESDGPAPERVSQAFPLSGPVSSSEMSSLQSLGPVQSWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQDQENDIFLGWEKGAAKKWGKSKRKGGTDLSLEEMKKQAAVQCLRSASDENSGIESLVEELCSKLKDIQNKQKEKEKHGIKKSDISQSPEPDESLSSKDQVEMYYEAFPPLSEKPVCLQEIMTVWNTAKACTYSSSSSSAVPQTSTDTSSPKDCTSEGEAFKDRTVDAPSSTSTTSEKAQQRRTKREKENRFHGSATGMPDDQVAPHSKRQARHRSEGRFRPRSWSSGSSEAGSSSSGNQGDQAPSCKSVRIRHKSREVSGRNKKGRSGGGQVKLALKVIDKEERKNARGNMSTTGGPPKQQQHYMKKGKRPLREIRKDANLVEAQESGGEASKKEYMEEPLWYTEPIAEYFVPLSRSKLETKYRSKEDSSNDLAMSIDVDCLSERIQGICIANSCFQRAYLAAGTFVDGHFIEMPGEGDEEASELNGIPSCPPPEDGQDLDDEHLSEFTHFYEVDLYQSILDPSASDAVQESRILSMIRQKSVERKHFEAGCVVLDGLELQGESAIRVDSLGASEAEVSITQDMENIAQVWECCSSSSLEDLEGESCPGDSPGRLSPVLDSVPFNFSKLSGAYVGSRLQEASGSSSAPNPYFSLFEVQYDSPTFSFPCDSLTGGQENVDSSSCLDPQGNKQSRLLIWTKNSAFDETEHCSNLSTRTCSPWSHSEETRSDSEQVSAPADESAQFGNEEVSCISLIPPLCLEEELLDFFQENSSHQQEETSVSAESNQPFNKKSKLESVCGIALEQDESKLYNAVVFSDVPNQQSDEYTSGIIKDIWMAIGDRDCVLTLGVKNTGEHLFSEDSTSYQCSCLDKDAKGEIIQKKAVQCSEYHLWDGQKENDGLPKNKLTKMNDGDYTAPAKPWNCNSQESTSFILGGVYGELKTLSGDREWAMIPPGDACGSLLQCAAATSSDMVTIAGADVFMNTSSCFAPGHKPLWRPIVSLGQNEQATKGTGEGLNKGFSVVFHEDLLGSCGGFRGEESGLDYPFSSFDLNNPFSQVLHVECSFEPEDMASFSPGFKPKSILCSDKEPFCPWLYGINRTQYRAIRISPRTHFRPISASELSPGGCSESDVESEKEEASIPVGQADLFDDPQADLKPLEEDAECEGPYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQEGGSTLLPITEQEICVHCEVAADSVPCSHVQSSVLLQEETSGETEPCNCVATGQIPKSGKSLDVAQDMHEFPLLNFGEQCLTNMQQEECWWQSSLCSPLFPGSQCGGSSNV", "length": 1325 }, "evidence": [ { "id": "E1B9H2", "url": "https://omabrowser.org/oma/group/E1B9H2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80U59-1", "protein_name": "Uncharacterized protein KIAA0232", "gene_name": "Kiaa0232", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPVCTVVVDGLPSESTSSSYPGPVSVSDMSLLHALGPVQTWLGQELEKCGIDAMIYSRYILSLLLHDSYDYDLQEQENDILSWEKGAYKKWGRSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCCRLKDLQSEQEEKIHKKLEGSPSPEEELSPTAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSKPCSYSSSSSSSTVPPASTDTSSPKDCNSESEAVRERSSVASVPMHEKAQSRSRHEKESKLSSSTIEEKPAFYKRQIRHKPEGKTRPRSWSSGSSEAGSSSSGNQGELKASMKYVKVRHKAREIRNRKGRNGQNRHSLKHCGKAERGVHAGSGGSSSSSSNGSIRQLCKRGKRPAKETGRSDSGNTAVKDLYVDSRNNKEYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNREDTSTLTAEAVEDLSDSVRGLCISNSNIHRTYLAAGTFIDGHFVEMPAVINEDIDLAGTSLCSLPEDNKYLDDIHLSELTHFYEVDIDQSMLDPGASETMQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWTDSTSSVGAEGFFLQDLGNLAQFWECCSSSSGDADGESFGGDSPVRLSPILDSTMLSSHILAGNQEPFSNINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGSEHADSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEEARSDNETLNIQFEESTQFTAEDINYVVPRVSSDFVDEELLDFLQDETCQQNSRTLGEIPTLVFKKRSKLESVCGIQLEQKAESKNFETTHACSESSPHGDGYSSGVIKDIWTKMVGRSSVAAVETERTGEELFSTDVNNYCCCLDTEAKMEALQEPSRAVQRSEYHLWEGQKENMEKRAFVSSELSKVDGGDYTTPSKPWDVAQDKENTFILGGVYGELKTFNSDGEWAVVPPGHTKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSFEQSDMPKRGENGVNKGFSFIFHEDLLGACSNFQVEDPGLEYSLSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICGVERTQYRAIRISPRTHFRPISASELSPGGGSESEFESEKDEASVPIPSHVDVFEDPQADLKPLEEDAEKEGHYYGKLELESGKFLPRLKKSGMEKSAQTSLDSQEEATGILPKQNQCLECNFNESLEINLESSAANCKIMTQCEEEMSEFCSCKAGCQFPACEDNPVSSGQLEEFPVLNTDVQEVTRNQEKQSWWEKALYSPLFPTSECEECYTNAKGENGIEECPDAKETPSREERLLDFNRVSSVYEARCTGERGSETKPNGLHRKMCSSASSDTGDTGSEAGGEWVGPSREELFSRTHL", "length": 1396 }, "evidence": [ { "id": "E1B9H2", "url": "https://omabrowser.org/oma/group/E1B9H2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92628-1", "protein_name": "Uncharacterized protein KIAA0232", "gene_name": "KIAA0232", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYPICTVVVDGLPSESSSSSYPGPVSVSEMSLLHALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQENDIFLGWEKGAYKKWGKSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCSRLKDLQSKQEEKIHKKLEGSPSPEAELSPPAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSKVCSYSSSSSSSTAPPASTDTSSPKDCNSESEVTKERSSEVPTTVHEKTQSKSKNEKENKFSNGTIEEKPALYKKQIRHKPEGKIRPRSWSSGSSEAGSSSSGNQGELKASMKYVKVRHKAREIRNKKGRNGQSRLSLKHGEKAERNIHTGSSSSSSSGSVKQLCKRGKRPLKEIGRKDPGSTEGKDLYMENRKDTEYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNRQDTSDLTSEAVEELSESVHGLCISNNNLHKTYLAAGTFIDGHFVEMPAVINEDIDLTGTSLCSLPEDNKYLDDIHLSELTHFYEVDIDQSMLDPGASETMQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWTDSTSSVGAEGLFLQDLGNLAQFWECCSSSSGDADGESFGGDSPVRLSPILDSTVLNSHLLAGNQELFSDINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGNENTDSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEETRSDNETLNIQFEESTQFNAEDINYVVPRVSSNYVDEELLDFLQDETCQQNSRTLGEIPTLVFKKTSKLESVCGIQLEQKTENKNFETTQVCNESPHGDGYSSGVIKDIWTKMADTNSVATVEIERTDAELFSADVNNYCCCLDAEAELETLQEPDKAVRRSEYHLWEGQKESLEKRAFASSELSNVDGGDYTTPSKPWDVAQDKENTFILGGVYGELKTFNSDGEWAVVPPSHTKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSFEQNDQPKSGENGLNKGFSFIFHEDLLGACGNFQVEDPGLEYSFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICGVDRTQYRAIRISPRTHFRPISASELSPGGGSESEFESEKDEANIPIPSQVDIFEDPQADLKPLEEDAEKEGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQEESTGILSVGKQNQCLECSMNESLEIDLESSEANCKIMAQCEEEINNFCGCKAGCQFPAYEDNPVSSGQLEEFPVLNTDIQGMNRSQEKQTWWEKALYSPLFPASECEECYTNAKGESGLEEYPDAKETPSNEERLLDFNRVSSVYEARCTGERDSGAKSDGFRGKMCSSASSTSEETGSEGGGEWVGPSEEELFSRTHL", "length": 1395 }, "evidence": [ { "id": "E1B9H2", "url": "https://omabrowser.org/oma/group/E1B9H2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1289, "end_pos": 1291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 713, "end_pos": 715, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1289, "end_pos": 1291 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 713, "end_pos": 715 }, { "start_pos": 732, "end_pos": 734 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBA7-1", "uniprot_ac": "E1BBA7", "uniprot_id": "E1BBA7_BOVIN", "mass": { "chemical_mass": 30327.0, "monoisotopic_mass": 30327.0 }, "refseq": { "ac": "XP_024850568", "name": "transmembrane protein 221", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850568" }, "gene_names": [ { "name": "TMEM221", "type": "recommended", "evidence": [ { "id": "E1BBA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA7" } ] }, { "name": "TMEM221", "type": "synonym", "evidence": [ { "id": "XP_024850568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850568" } ] } ], "protein_names": [ { "name": "Transmembrane protein 221", "type": "synonym", "evidence": [ { "id": "E1BBA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA7/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 221", "type": "synonym", "evidence": [ { "id": "XP_024850568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850568" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBA7", "url": "https://www.uniprot.org/uniprotkb/E1BBA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM221", "url": "https://www.uniprot.org/uniprotkb/E1BBA7", "locus": { "chromosome": "7", "start_pos": 5677477, "end_pos": 5663181, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025767", "url": "https://www.ensembl.org/id/ENSBTAG00000025767" } ] } } ], "crossref": [ { "id": "E1BBA7", "url": "https://alphafold.ebi.ac.uk/entry/E1BBA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025767", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025767", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506272", "url": "https://www.ncbi.nlm.nih.gov/gene/506272", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506272", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506272", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPRMHRT", "url": "https://omabrowser.org/oma/group/CPRMHRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBA7", "url": "https://www.orthodb.org/?gene=E1BBA7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36132:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36132:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024850568", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850568", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3V0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3V0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBA7", "url": "https://www.uniprot.org/uniprotkb/E1BBA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBA7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBA7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARSYGGRVLAAMVLLGIPAAVLAALGAQLLFQLQAGRAELRGPRIDGLGPELGAGPRLPEDAAGALLPLAAALSALALVLGLTCLLLAALCGHLGAEMARGPGSNRSDWFLYDCRLLRHVALGLFCCGVSVYLAALSIYALLLFEIETGAAAASILGLGALVLVAALTHTLLQAARTTRRGVHELSPPHFEDDPVCPAEVSKAGPRAQPQQGTHHWTLYSSFPKLGDSLRPMVTDTAPAVMGGGRESCLPASRMHRTLSASEGRWGEVTHEMRSILGHRPAGSGKDSTLV", "length": 291, "header": "tr|E1BBA7-1|E1BBA7_BOVIN Isoform 1 of Transmembrane protein 221 OS=Bos taurus OX=9913 GN=TMEM221 PE=4 SV=2 CANONICAL=E1BBA7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3V0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V0/entry", "sequence": { "sequence": "MARSYGGRVLAAMVLLGIPAAVLAALGAQLLFQLQAGRAELRGPRIDGLGPELGAGPRLPEDAAGALLPLAAALSALALVLGLTCLLLAALCGHLGAEMARGPGSNRSDWFLYDCRLLRHVALGLFCCGVSVYLAALSIYALLLFEIETGAAAASILGLGALVLVAALTHTLLQAARTTRRGVHELSPPHFEDDPVCPAEVSKAGPRAQPQQGTHHWTLYSSFPKLGDSLRPMVTDTAPAVMGGGRESCLPASRMHRTLSANEETEAQRGAVTHQGSHGQY", "length": 281, "header": "tr|A0AAA9T3V0-1|E1BBA7_BOVIN Computationally mapped isoform of Transmembrane protein 221 OS=Bos taurus OX=9913 GN=TMEM221 PE=4 SV=1 CANONICAL=E1BBA7-1" }, "locus": { "chromosome": "7", "start_pos": 5676473, "end_pos": 5670170, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091138.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091138.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093477.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093477.1" } ] } }, { "isoform_ac": "E1BBA7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBA7/entry", "sequence": { "sequence": "MARSYGGRVLAAMVLLGIPAAVLAALGAQLLFQLQAGRAELRGPRIDGLGPELGAGPRLPEDAAGALLPLAAALSALALVLGLTCLLLAALCGHLGAEMARGPGSNRSDWFLYDCRLLRHVALGLFCCGVSVYLAALSIYALLLFEIETGAAAASILGLGALVLVAALTHTLLQAARTTRRGVHELSPPHFEDDPVCPAEVSKAGPRAQPQQGTHHWTLYSSFPKLGDSLRPMVTDTAPAVMGGGRESCLPASRMHRTLSASEGRWGEVTHEMRSILGHRPAGSGKDSTLV", "length": 291, "header": "tr|E1BBA7-1|E1BBA7_BOVIN Isoform 1 of Transmembrane protein 221 OS=Bos taurus OX=9913 GN=TMEM221 PE=4 SV=2 CANONICAL=E1BBA7-1" }, "locus": { "chromosome": "7", "start_pos": 5675986, "end_pos": 5670170, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047511.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047511.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044714.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044714.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506272", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506272", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B9L8-1", "protein_name": "Transmembrane protein 221", "gene_name": "TMEM221", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARSYGGRVLTAMILLGIPAAVLAALGAQLLFQLQAGRAELRGPRIDGLGPELGTGPGLPEDAAGALLPLAAALAALALVLGLTCLLLAALCGHLGAEMARGPGPGRSDWFLYDCRLLRHVALGLFCCGISVYLAALSIYALLLFEIETGAAAASVLGLGALILVAVLTHTLLRAARATRRGLHELSLPQFEDDPVRPAEVSKASSGAQPQQGIHHWTPYSSCPEPGDSLRPTVTATAPATMGGGWESRLPTSHIHRTLSASEGHWEEVTHEMRNILGHRPGGSGKDSTLV", "length": 291 }, "evidence": [ { "id": "E1BBA7", "url": "https://omabrowser.org/oma/group/E1BBA7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1ADT3-1", "protein_name": "Transmembrane protein 221", "gene_name": "TMEM221", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSYPQRTLTVLLLFGTLSAAMALLASSLIFQLPAGRTSPGSGPGAVRGALPESAAAVLLPVSAVLAALCLVLNVSCLLLCLLHGYFSTELCRGQPGPERADWFLLDSRTVRHAAIGLFCCGVSVYLTALAIYMLLLFELEAGIASACILSSGIIVLLVTVTHALLRASQLSRRSRSEISHTLYENDSAQHSETPGSNLNNKSTAVPRPRPEIHREFSFPPFLEHKSQLGSPASSNLTSSGSPGAHSEKESYHLPRTHRTLSAESALLQAQGKPWNGVTHEMRNVLARKPGASGKDSTLV", "length": 300 }, "evidence": [ { "id": "E1BBA7", "url": "https://omabrowser.org/oma/group/E1BBA7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A6NGB7-1", "protein_name": "Transmembrane protein 221", "gene_name": "TMEM221", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARSYGGRVLAAMTLLGIAAAVLAALGAQLLFQLQAGRAELRGLRAEGLGQELGAGPGLPEDAAGTLLPLAAALAALVLVLGFTCLLLAALCGHLGAELARGPGPRRSDWFLYDCRLLRHVALGLFCCGISVYLAALSIYALLLFEIETGAAAASILGSGTLVLVAVLTHTLLRAARAARRGLHELSPPSFEDDLARPAEVSKASPRAQPQQGIHRRTPYSTCPEPGDPFGSMATATAPAALEGGWESSLPASRMHRTLSAGLGHWDGVTHEMRRMLGHRPGSMGKDSTLV", "length": 291 }, "evidence": [ { "id": "E1BBA7", "url": "https://omabrowser.org/oma/group/E1BBA7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "E7EXZ1-1", "protein_name": "Transmembrane protein 221", "gene_name": "tmem221", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTHSYSQRSLVILAFLGILSSIMAVLSVILIFQLQTQQAVIKDSPTFVPKDITAVLLPVSTVLSALSLTLNLSSVVVCLLHSYFATEICRGEPDTQRADWFLMDSRAVRHVTIGLFCLGVSVYLAAMSIYMVLVFEVETGIASVCVLSSGVLVLLLIIIHSLIRAARAAKHYRTDHLHTMYHNNPEQIRTSNLSIMENPRRQHSLANLPSHFINPAHMEPKSQYSTSNGPQAHSSDKDGCSGSGRTHRTLSTESGLFHAQAKPWNGVNSEMRSVLARKATIKDSTLV", "length": 287 }, "evidence": [ { "id": "E1BBA7", "url": "https://omabrowser.org/oma/group/E1BBA7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBA7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 291, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBA7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBA7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9H3-1", "uniprot_ac": "E1B9H3", "uniprot_id": "E1B9H3_BOVIN", "mass": { "chemical_mass": 101933.0, "monoisotopic_mass": 101933.0 }, "refseq": { "ac": "NP_001068766", "name": "cell cycle and apoptosis regulator protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766" }, "gene_names": [ { "name": "CCAR2", "type": "recommended", "evidence": [ { "id": "E1B9H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ] }, { "name": "CCAR2", "type": "synonym", "evidence": [ { "id": "NP_001068766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766" } ] } ], "protein_names": [ { "name": "Cell cycle and apoptosis regulator 2", "type": "synonym", "evidence": [ { "id": "E1B9H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H3/entry#names_and_taxonomy" } ] }, { "name": "cell cycle and apoptosis regulator protein 2", "type": "synonym", "evidence": [ { "id": "NP_001068766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766" } ] }, { "name": "p30 DBC protein", "type": "synonym", "evidence": [ { "id": "NP_001068766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766" } ] } ], "function": [ { "annotation": "Expression of DBC1-A was extraordinary high in calves adipose tissue, which implicated its potential key role in regulating calve adipocyte development", "evidence": [ { "database": "RefSeq", "id": "NP_001068766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766" }, { "database": "PubMed", "id": "23845782", "url": "https://glygen.org/publication/PubMed/23845782" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCAR2", "url": "https://www.uniprot.org/uniprotkb/E1B9H3", "locus": { "chromosome": "8", "start_pos": 69923010, "end_pos": 69908027, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005469", "url": "https://www.ensembl.org/id/ENSBTAG00000005469" } ] } } ], "crossref": [ { "id": "E1B9H3", "url": "https://alphafold.ebi.ac.uk/entry/E1B9H3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005469", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005469", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507114", "url": "https://www.ncbi.nlm.nih.gov/gene/507114", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507114", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507114", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDALCQQ", "url": "https://omabrowser.org/oma/group/WDALCQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9H3", "url": "https://www.orthodb.org/?gene=E1B9H3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14304", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14304", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14304:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14304:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14444", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T525", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T525-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T525-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9H3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9H3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQNARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYTVDSPVFDFLELQRRYRTLLVPSDFLAVHLSWLSAFPVSQPFSLHHPSRIQVSSEKEPAADAGAEPPPTDSDPTYSSKVLLLSSPGLEELYRCCMLFVDDMAEPRETPEHPLKQIKFLLGWKDDEAVLVGGEWSPSLDGLDPKGDPQVLVRTATRCAQAQAGIDLSACTKWWRFAEFQYLQAGPPRRLQTVVVYLPDIWTIMPTLEEWEALCQQKAAEAAPPPPEVPVETEPTEQPADGSEQAADTSKSAENPEVTAQQEVDTDLPEAPPPPLEPAVMARSRCVNLSLQSIVEDRRPKERISFEATVLAELFLEMLQRDFGYRIYKTLLSLPEKVVAPPEPEKEEAAKEEEAVKEEAKESKDEVQSEGTAAEADAPPKEDGLLPKPPSSGGEDEEKPRGEASEDLCEMALDPELLLLRDDGEEEFAGAKLEDSEVRSVASNQSEMEFSTLQDMPKELEPSAVLPVDCLLAFVYFDANWCGYLHRRDLERILLTLGLRLSAEQAKQLVSRAVSQNICQYRSLQYSRPEGPDGALPEDLLFGNLDLLPPPGKSGKPGTTPVEHKGLVSHNGSLINVGNLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLATEMQDLRARLAEAEEMARTAERQKNQLQRLLQEFRRRLTTLQLDTQRMLEKADSWVEKEEPAPSN", "length": 916, "header": "tr|E1B9H3-1|E1B9H3_BOVIN Isoform 1 of Cell cycle and apoptosis regulator 2 OS=Bos taurus OX=9913 GN=CCAR2 PE=4 SV=1 CANONICAL=E1B9H3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T525-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T525/entry", "sequence": { "sequence": "MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQNARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYTVDSPVFDFLELQRRYRTLLVPSDFLAVHLSWLSAFPVSQPFSLHHPSRIQVSSEKEPAADAGAEPPPTDSDPTYSSKVLLLSSPGLEELYRCCMLFVDDMAEPRETPEHPLKQIKFLLGWKDDEAVLVGGEWSPSLDGLDPKGDPQVLVRTATRCAQAQAGIDLSACTKWWRFAEFQYLQAGPPRRLQTVVVYLPDIWTIMPTLEEWEALCQQKAAEAAPPPPEVPVETEPTEQPADGSEQAADTSKSAENPEVTAQQEVDTDLPEAPPPPLEPAVMARSRCVNLSLQSIVEDRRPKERISFEATVLAELFLEMLQRDFGYRIYKTLLSLPEKVVAPPEPEKEEAAKEEEAVKEEAKESKDEVQSEGTAAEADAPPKEDGLLPKPPSSGGEDEEKPRGEASEDLCEMALDPELLLLRDDGEEEFGAKLEDSEVRSVASNQSEMEFSTLQDMPKELEPSAVLPVDCLLAFVYFDANWCGYLHRRDLERILLTLGLRLSAEQAKQLVSRAVSQNICQYRSLQYSRPEGPDGALPEDLLFGANWALRPPGDGGGWAAFSHFPSLSLLLALLGNLDLLPPPGKSGKPGTTPVEHKGLVSHNGSLINVGNLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLATEMQDLRARLAEAEEMARTAERQKNQLQRLLQEFRRRLTTLQLDTQRMLEKADSWVEKEEPAPSN", "length": 946, "header": "tr|A0AAA9T525-1|E1B9H3_BOVIN Computationally mapped isoform of Cell cycle and apoptosis regulator 2 OS=Bos taurus OX=9913 GN=CCAR2 PE=4 SV=1 CANONICAL=E1B9H3-1" }, "locus": { "chromosome": "8", "start_pos": 69922238, "end_pos": 69909030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092926.1" } ] } }, { "isoform_ac": "E1B9H3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9H3/entry", "sequence": { "sequence": "MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQNARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYTVDSPVFDFLELQRRYRTLLVPSDFLAVHLSWLSAFPVSQPFSLHHPSRIQVSSEKEPAADAGAEPPPTDSDPTYSSKVLLLSSPGLEELYRCCMLFVDDMAEPRETPEHPLKQIKFLLGWKDDEAVLVGGEWSPSLDGLDPKGDPQVLVRTATRCAQAQAGIDLSACTKWWRFAEFQYLQAGPPRRLQTVVVYLPDIWTIMPTLEEWEALCQQKAAEAAPPPPEVPVETEPTEQPADGSEQAADTSKSAENPEVTAQQEVDTDLPEAPPPPLEPAVMARSRCVNLSLQSIVEDRRPKERISFEATVLAELFLEMLQRDFGYRIYKTLLSLPEKVVAPPEPEKEEAAKEEEAVKEEAKESKDEVQSEGTAAEADAPPKEDGLLPKPPSSGGEDEEKPRGEASEDLCEMALDPELLLLRDDGEEEFAGAKLEDSEVRSVASNQSEMEFSTLQDMPKELEPSAVLPVDCLLAFVYFDANWCGYLHRRDLERILLTLGLRLSAEQAKQLVSRAVSQNICQYRSLQYSRPEGPDGALPEDLLFGNLDLLPPPGKSGKPGTTPVEHKGLVSHNGSLINVGNLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLATEMQDLRARLAEAEEMARTAERQKNQLQRLLQEFRRRLTTLQLDTQRMLEKADSWVEKEEPAPSN", "length": 916, "header": "tr|E1B9H3-1|E1B9H3_BOVIN Isoform 1 of Cell cycle and apoptosis regulator 2 OS=Bos taurus OX=9913 GN=CCAR2 PE=4 SV=1 CANONICAL=E1B9H3-1" }, "locus": { "chromosome": "8", "start_pos": 69922238, "end_pos": 69909030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007194.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007194.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007194.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007194.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 300, "start_aa": "Thr", "end_pos": 300, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr300", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Molecular characterization, alternative splicing and expression analysis of bovine DBC1.", "journal": "Gene", "date": "2013-09-25", "authors": "Li Mingxun, Sun Xiaomei, Hua Liushuai, Huang Yongzhen, Wang Jing, Cao Xiukai, Zhan Zhaoyang, Lan Xianyong, Chen Hong", "evidence": [ { "database": "RefSeq", "id": "NP_001068766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068766" } ], "reference": [ { "type": "PubMed", "id": "23845782", "url": "https://glygen.org/publication/PubMed/23845782" } ] } ], "pathway": [ { "id": "bta:507114", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507114", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LM55-1", "protein_name": "Cell cycle and apoptosis regulator 2", "gene_name": "Ccar2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQNARHLQSGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYAVDSPTCDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLGQPFSLHHPSRIQVSSEKEAAPDTGAEPSPEDSDPTYSSKVLLLSSPGLEEFYRCCMLFVDDMAEPRETPEHPLKQLKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSTCTKWWRFAEFQYLQPGPPRQLHTVVVYLPDVWTIMPTLEEWEALCQQKATEAAPQPQEASGEAEATEQAPDVSEQADTSKQDTETAEATTQQDVDTELPEAPPPPLEPAVMARPGCVNLSLYGIVEDRRPKERISFEVVVLAELFVEMLQRDFGYRIYKVLLSLPEKVVSPPEPEKEEAAKEDVVKEEEAVKEEAVKVSKDEVQNEGTAAEADSPLKEDGLLPKQPSAGGEEEEKARGEAAEDLCEMALDPDLLLLRDDGEEEFAGAKLEETEVRSVASNQSEMEYSSLQDMPKELDPSAVLPLDCLLAFVFFDANWCGYLHRRDLERILLTLGIRLSAEQAKQLVSRVVAQNICQYRSLQYSRAEALDDGLPEDVLFGNLDLLPPSGKSTKPGAAPTEHKGLVPHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLAAEMQELRARLAEAEETARTVERQKNQLQRQMQDFRRRLTPLHLEMQRIVEKADSWVEKEEPTPSN", "length": 922 }, "evidence": [ { "id": "E1B9H3", "url": "https://omabrowser.org/oma/group/E1B9H3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N163-1", "protein_name": "Cell cycle and apoptosis regulator protein 2", "gene_name": "CCAR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQFKRQRINPLPGGRNFSGTASTSLLGPPPGLLTPPVATELSQNARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYTVDSPICDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLHHPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYRCCMLFVDDMAEPRETPEHPLKQIKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSGCTKWWRFAEFQYLQPGPPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEAAPPTQEAQGETEPTEQAPDALEQAADTSRRNAETPEATTQQETDTDLPEAPPPPLEPAVIARPGCVNLSLHGIVEDRRPKERISFEVMVLAELFLEMLQRDFGYRVYKMLLSLPEKVVSPPEPEKEEAAKEEATKEEEAIKEEVVKEPKDEAQNEGPATESEAPLKEDGLLPKPLSSGGEEEEKPRGEASEDLCEMALDPELLLLRDDGEEEFAGAKLEDSEVRSVASNQSEMEFSSLQDMPKELDPSAVLPLDCLLAFVFFDANWCGYLHRRDLERILLTLGIRLSAEQAKQLVSRVVTQNICQYRSLQYSRQEGLDGGLPEEVLFGNLDLLPPPGKSTKPGAAPTEHKALVSHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLAAEMQELRVRLAEAEETARTAERQKSQLQRLLQELRRRLTPLQLEIQRVVEKADSWVEKEEPAPSN", "length": 923 }, "evidence": [ { "id": "E1B9H3", "url": "https://omabrowser.org/oma/group/E1B9H3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VDP4-1", "protein_name": "Cell cycle and apoptosis regulator protein 2", "gene_name": "Ccar2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQNARHLQSGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLSPYRVHLTPYTVDSPTCDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLGQPFSLHHPSRIQVSSEKEAAPDTGAEPSPEDSDPTYSSKVLLLSSPGLEEFYRCCMLFVDDMAEPRETPEHPLKQLKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSTCTKWWRFAEFQYLQPGPPRQLHTVVVYLPDVWTIMPTLEEWEALCQQKATEAAPQPHEASGEAEATEQAPDVSEQADTSKQNTETMEATTQQDVDTDLPEAPPPPLEPAVMARPRCVNLSLYGIVEDRRPKERISFEVVVLAELFVEMLQRDFGYRIYKTLLSLPEKVVSPPEPEKEEAAKEDAVKEEEAVKEEAVKVSKDEVQNEGTAAESDSPLKEDGLLPKRPSSGGEEEEKARGEAAEDLCEMALDPDLLLLRDDGEDEFAGAKLEETEVRSVASNQSEMEYSSLQDMPKELDPSTVLPLDCLLAFVFFDANWCGYLHRRDLERVLLTLGIRLSAEQAKQLVSRVVAQNICQYRSLQYSRAEVLDDGLPEDVLFGNLDLLPPSGKSTKPGAAPTEHKGLVPHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLAAEMQELRARLAEAEETARTAERQKNQLQRQMQDFRRRLTPLHLEMQRIVEKADSWVEKEEPTPSN", "length": 922 }, "evidence": [ { "id": "E1B9H3", "url": "https://omabrowser.org/oma/group/E1B9H3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "enzyme inhibitor activity", "id": "GO:0004857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "DBIRD complex", "id": "GO:0044609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044609", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:1902230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902230", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "response to UV", "id": "GO:0009411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009411", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "regulation of circadian rhythm", "id": "GO:0042752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "mitochondrial fragmentation involved in apoptotic process", "id": "GO:0043653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043653", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription elongation", "id": "GO:0032784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032784", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "positive regulation of DNA damage checkpoint", "id": "GO:2000003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000003", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1B9H3", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 672, "end_pos": 674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 799, "end_pos": 801, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9H3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 916, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9H3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9H3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H3" }, { "id": "SM01122", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01122" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DBC1/CARP1 catalytically inactive NUDIX hydrolase", "eco_id": "ECO_0000259", "start_pos": 339, "end_pos": 462, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 300 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 672, "end_pos": 674 }, { "start_pos": 799, "end_pos": 801 }, { "start_pos": 847, "end_pos": 849 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC65-1", "uniprot_ac": "E1BC65", "uniprot_id": "E1BC65_BOVIN", "mass": { "chemical_mass": 127695.0, "monoisotopic_mass": 127695.0 }, "refseq": { "ac": "XP_002697080", "name": "RNA-binding protein 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697080" }, "gene_names": [ { "name": "RBM6", "type": "recommended", "evidence": [ { "id": "E1BC65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC65" } ] }, { "name": "RBM6", "type": "synonym", "evidence": [ { "id": "XP_002697080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697080" } ] } ], "protein_names": [ { "name": "RNA binding motif protein 6", "type": "synonym", "evidence": [ { "id": "E1BC65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC65/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002697080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697080" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC65", "url": "https://www.uniprot.org/uniprotkb/E1BC65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM6", "url": "https://www.uniprot.org/uniprotkb/E1BC65", "locus": { "chromosome": "22", "start_pos": 50246633, "end_pos": 50321305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006328", "url": "https://www.ensembl.org/id/ENSBTAG00000006328" } ] } } ], "crossref": [ { "id": "E1BC65", "url": "https://alphafold.ebi.ac.uk/entry/E1BC65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006328", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006328", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12314", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12314", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12563", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12563", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100296443", "url": "https://www.ncbi.nlm.nih.gov/gene/100296443", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296443", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296443", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RNIPHAD", "url": "https://omabrowser.org/oma/group/RNIPHAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC65", "url": "https://www.orthodb.org/?gene=E1BC65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13948", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13948", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13948:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13948:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC65", "url": "https://www.uniprot.org/uniprotkb/E1BC65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC65-1", "url": "https://www.uniprot.org/uniprotkb/E1BC65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGQHGDYRGGEGHGHDFRGGDFSSSDFQSRDSSQLDFRGRDIHSGDLRDREGPPMDYRGGDGTSLDYRGRETSHMNYREREAHTGDFRGRDVPPPDFRGRGTYDLDFRGRDGARADFRGRDLSDLDFRARDQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTSDLDFRDRNTPHADFRGRHRSRTDQDFRGREGGPCVEFKDREMPSADPDILDYVQPSTQNREHSGMNVNKREESAHDHTTERPAFGIQKGEFEHSETGEGEKQGVAFDHASSPDFQNSQSPLQDQDKSQHSGGEQQSSDAGMFKEEGGLDFLGRQDTDYRSMEYCDVDHRLPGSQIFGYGQSKSFPEGKTSQDAQRDLQDQDYRTGPSEEKPSKLIRLNGVPENATKEEILNAFWTPDGMPVKDLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSLDFWYCKWCKASTGGHRSSCSFCKCPREEAKQELVTYPQPQKTSIPALSEKQASQPSRSADKESEPKKREEGQEPRLGHQKRESERYLPPRREGLTFRRDREKEPWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANIRIIKNRTGHMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIAGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDVNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGSPEEEDIKEKKPSSQGKSSSKKETSKRDSKEKKDRGVTRFQENASEGTAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPPQREELTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKERGNDRREKLQSLDSPERKRIKYSRETDSDRKPVGKEGINSSSTGGYVQQATGWRKGAGLGYGHPGLGSAEETESRMRGPNVGAPGRTSKRQSNETYRDAVRRVMFARYKELD", "length": 1120, "header": "tr|E1BC65-1|E1BC65_BOVIN Isoform 1 of RNA binding motif protein 6 OS=Bos taurus OX=9913 GN=RBM6 PE=4 SV=2 CANONICAL=E1BC65-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C5/entry", "sequence": { "sequence": "MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGQHGDYRGGEGHGHDFRGGDFSSSDFQSRDSSQLDFRGRDIHSGDLRDREGPPMDYRGGDGTSLDYRGRETSHMNYREREAHTGDFRGRDVPPPDFRGRGTYDLDFRGRDGARADFRGRDLSDLDFRARDQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTSDLDFRDRNTPHADFRGRHRSRTDQDFRGREGGPCVEFKDREMPSADPDILDYVQPSTQNREHSGMNVNKREESAHDHTTERPAFGIQKGEFEHSETGEGEKQGVAFDHASSPDFQNSQSPLQDQDKSQHSGGEQQSSDAGMFKEEGGLDFLGRQDTDYRSMEYCDVDHRLPGSQIFGYGQSKSFPEGKTSQDAQRDLQDQDYRTGPSEEKPSKLIRLNGVPENATKEEILNAFWTPDGMPVKDLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSLDFWYCKWCKASTGGHRSSCSFCKCPREEAKQELVTYPQPQKTSIPALSEKQASQPSRSADKESEPKKREEGQEPRLGHQKRESERYLPPRREGLTFRRDREKEPWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANIRIIKNRTGHMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIAGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDVNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGSPEEEDIKEKKPSSQGKSSSKKETSKRDSKEKKDRGVTRFQENASEGTAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPPQREELTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKERGNDRREKLQSLDSPERKRIKYSRETDRLKVG", "length": 1040, "header": "tr|A0AAA9T9C5-1|E1BC65_BOVIN Computationally mapped isoform of RNA binding motif protein 6 OS=Bos taurus OX=9913 GN=RBM6 PE=4 SV=1 CANONICAL=E1BC65-1" }, "locus": { "chromosome": "22", "start_pos": 50321243, "end_pos": 50246867, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123230.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123230.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095301.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095301.1" } ] } }, { "isoform_ac": "E1BC65-1", "url": "https://www.uniprot.org/uniprotkb/E1BC65/entry", "sequence": { "sequence": "MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGQHGDYRGGEGHGHDFRGGDFSSSDFQSRDSSQLDFRGRDIHSGDLRDREGPPMDYRGGDGTSLDYRGRETSHMNYREREAHTGDFRGRDVPPPDFRGRGTYDLDFRGRDGARADFRGRDLSDLDFRARDQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTSDLDFRDRNTPHADFRGRHRSRTDQDFRGREGGPCVEFKDREMPSADPDILDYVQPSTQNREHSGMNVNKREESAHDHTTERPAFGIQKGEFEHSETGEGEKQGVAFDHASSPDFQNSQSPLQDQDKSQHSGGEQQSSDAGMFKEEGGLDFLGRQDTDYRSMEYCDVDHRLPGSQIFGYGQSKSFPEGKTSQDAQRDLQDQDYRTGPSEEKPSKLIRLNGVPENATKEEILNAFWTPDGMPVKDLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSLDFWYCKWCKASTGGHRSSCSFCKCPREEAKQELVTYPQPQKTSIPALSEKQASQPSRSADKESEPKKREEGQEPRLGHQKRESERYLPPRREGLTFRRDREKEPWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANIRIIKNRTGHMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIAGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDVNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGSPEEEDIKEKKPSSQGKSSSKKETSKRDSKEKKDRGVTRFQENASEGTAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPPQREELTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKERGNDRREKLQSLDSPERKRIKYSRETDSDRKPVGKEGINSSSTGGYVQQATGWRKGAGLGYGHPGLGSAEETESRMRGPNVGAPGRTSKRQSNETYRDAVRRVMFARYKELD", "length": 1120, "header": "tr|E1BC65-1|E1BC65_BOVIN Isoform 1 of RNA binding motif protein 6 OS=Bos taurus OX=9913 GN=RBM6 PE=4 SV=2 CANONICAL=E1BC65-1" }, "locus": { "chromosome": "22", "start_pos": 50321243, "end_pos": 50246757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008300.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008300.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008300.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008300.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296443", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296443", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PAD2-1", "protein_name": "RNA binding motif protein 6", "gene_name": "RBM6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWGDHRQGNRTGSFRGSQEERFAPGWNRDYPPSLDSLAQERHSGNFSGRESLPFDIQALAGLLNPQFANREEPSFSFGARDGPRSDFRGGEGHHDFRGRDFPPSDFQSRDESQLDFRGREPPPSEYRGRDMYSGDFREREGPPMDFRGGDIPPVDYRNRETFRMNYRDREAHSMDYRGRDEPPSDFRGRGSFDLDFRGRDGSHSDFRARDVPELDYRGRDHSYSDFRNRDVPDLDFRGVGTSDLDFRNRNAPSSDFRNRHRSRSDQDFRSRDMPPPMDFSDREMPPVDQSLVDFRRNQSTIPLAEREGSGLNTGKREEPALGLERTPFGSQKGEFQHSEAPAREEESLGLGLKDNASHNFQNSRGPLPALQDQEEQPQTFANKQQQQQQLSGGEQQRSDSDLGLKGEDDLDFLGRQDTDYRNIEYRDVDHRLPACQLFDYEHGKSFSEGKPSKDSRPYKSLQDQDYRTCPEFVKPSKLIRLGGVPETATKDDILNAFRGPDGMPVKNLRLKDYSSGYDYRYVCVEFSLLEEAIGCMEANQGTLTIGGEEVTLEYTLCPEFWRCKRCKVCNVGYRSSCSYCKLPRDGNRAGSESKGGPEGEDASSEQEFTAETKLEKPEQELPVQPGSPKQPLQASDPAPQQECQPQEQEPRKRDEGRERRPSQEKRRDTDRHQELPSQREGEEATPQEGGGSRTIMLKRITRFTPPEVIVGLLAPYVRISTSNVRIMKNKAGRMGQTYGFIELDSHAEALRLLKILQNLDPPICIDGRTLEVNLATGRRRNDYGEHGDNSYYNQGRRGMRDRRGGESQRRTRAQSPSDVSTYIYDPETGNYYDPIAGTYYDPRTQREVTIDREPCSSPPENRRRRHESQERTSERKEPHSRDNRDKKEKGKNTPAKNEPGEERFFTEDVFKKPLPPSVKKDETAGLNDCGEEKFFAEDVFKKPLPPSVKKDESAARPKVVNPLIGLLGEYGGDSDNEEEEEEEEQAQWLPSPHPPAQREEQPRRAKAGDDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSNLHKQNLEIHMKIKRSEQELAYLEKREREGRYKDKGNDRREKFQQMDSPERKRFRYDRGPESDYDPRIDSNNKGNRMLQSTGWKKGFGHNQQGTTSPMEAENRKRGPGLGAQGRPNRRQSNETYRDAVRRVMFARYKELE", "length": 1180 }, "evidence": [ { "id": "E1BC65", "url": "https://omabrowser.org/oma/group/E1BC65/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2MIY9-1", "protein_name": "RNA-binding protein 6 isoform X1", "gene_name": "Rbm6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWGDSRSANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGPHGDYQGGEGPGHDFRGGDFSSSDFQSRDSAQLDFRNRDMHSGDFRDREGPPMDYRGGDGTPMDYRGRETPHMNYRDRDSHPIDFRSRDVPPSDFRGRGTYDLDFRGRDGSHADFRGRDLSDLDFRSRDQSRSDFRNRDVSDLDLRDKEGTQVDFRGRGSATTDLDFRSRDAAHSDFRGRHRSRTYQDFRGREVGPCMEFKDREMPPVDPKILDYIQPSTQEREHSGVNVNKREEPTHDHAMEMAAFGVQKGEFEHSETREGETQSGTFEHESPSDFQNSQSPVQDQDKPKLPGGEQQSSDAGLFKEEGDLDFLGRQDTDYRNIEYCDVDHRLPGSQIFGYGQNKSFPQGKMSRDAQQELQDQDYRTGPSEEKPNRLIRLSGVPKNATKEEILNAFRTSDGIPVKELQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSPDFWYCKRCKASTGGHQSSCSFCKGPKEEVKQELVSYPQPQKTSIPVPSEKQPNQPRPADKEHEFRKREEGQESRSGHQKRDSERYFPHSRREGLTFRRDREKESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVHLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGNRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPESPEEEESKEKKSTSQGKSSSKKETSKRDSKEKKDRGVTKFQESTSEGKSPPEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQAPPVQLRTAQPQQREELTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGRFKERGNDRREKLQSFDSPERKRIKYSRETDSDRNPVDKEDTDTNSKGGCAQQAAGWRKGTGLGYSHPGLGSSEETEGRMRGPGGAPGRTSKRQSNETYRDAVRRVMFARYKELD", "length": 1119 }, "evidence": [ { "id": "E1BC65", "url": "https://omabrowser.org/oma/group/E1BC65/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BC65", "url": "https://www.uniprot.org/uniprotkb/E1BC65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BC65", "url": "https://www.uniprot.org/uniprotkb/E1BC65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "E1BC65", "url": "https://www.uniprot.org/uniprotkb/E1BC65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1047, "end_pos": 1049, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1101, "end_pos": 1103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 689, "end_pos": 691, "annotation": "n_glycosylation_sequon" }, { "start_pos": 741, "end_pos": 743, "annotation": "n_glycosylation_sequon" }, { "start_pos": 863, "end_pos": 865, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC65-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1120, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC65-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC65" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC65" }, { "id": "PS50174", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000259", "start_pos": 1048, "end_pos": 1094, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BC65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC65" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 456, "end_pos": 536, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1047, "end_pos": 1049 }, { "start_pos": 1101, "end_pos": 1103 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 689, "end_pos": 691 }, { "start_pos": 741, "end_pos": 743 }, { "start_pos": 863, "end_pos": 865 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AFD7-1", "uniprot_ac": "A0AAF7AFD7", "uniprot_id": "A0AAF7AFD7_BOVIN", "mass": { "chemical_mass": 62315.0, "monoisotopic_mass": 62315.0 }, "refseq": { "ac": "XP_059738834", "name": "EH domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738834" }, "gene_names": [ { "name": "EHD1", "type": "recommended", "evidence": [ { "id": "A0AAF7AFD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ] }, { "name": "EHD1", "type": "synonym", "evidence": [ { "id": "XP_059738834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738834" } ] } ], "protein_names": [ { "name": "EH domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAF7AFD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7/entry#names_and_taxonomy" } ] }, { "name": "EH domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059738834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738834" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EHD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7", "locus": { "chromosome": "29", "start_pos": 43084378, "end_pos": 43105119, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050712", "url": "https://www.ensembl.org/id/ENSBTAG00000050712" } ] } } ], "crossref": [ { "id": "A0AAF7AFD7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AFD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00052", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00052", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09913", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09913", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511908", "url": "https://www.ncbi.nlm.nih.gov/gene/511908", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031692", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031692", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11216:SF127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11216:SF127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00350", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00350", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16880", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16880", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18150", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18150", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059738834", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738834", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AFD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLTEEPGTAASPVSSSMFSWVSKDARRKKEPELFQTVSEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPNLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPAQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDRDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE", "length": 551, "header": "tr|A0AAF7AFD7-1|A0AAF7AFD7_BOVIN Isoform 1 of EH domain-containing protein 1 OS=Bos taurus OX=9913 GN=EHD1 PE=4 SV=1 CANONICAL=A0AAF7AFD7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K8/entry", "sequence": { "sequence": "MGHVYTARSLSCFWPHSPGFAAHLIRTDVNLLARLLTRPFYVCCFSEPAENPPVLVFSPLTPSLAGAPGRAFIYSICALLLARFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPNLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPAQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDRDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE", "length": 482, "header": "tr|A0AAA9T9K8-1|A0AAF7AFD7_BOVIN Computationally mapped isoform of EH domain-containing protein 1 OS=Bos taurus OX=9913 GN=EHD1 PE=4 SV=1 CANONICAL=A0AAF7AFD7-1" }, "locus": { "chromosome": "29", "start_pos": 43100991, "end_pos": 43084617, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130432.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130432.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093550.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093550.1" } ] } }, { "isoform_ac": "A0AAF7AFD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7/entry", "sequence": { "sequence": "MSLTEEPGTAASPVSSSMFSWVSKDARRKKEPELFQTVSEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPNLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPAQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDRDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE", "length": 551, "header": "tr|A0AAF7AFD7-1|A0AAF7AFD7_BOVIN Isoform 1 of EH domain-containing protein 1 OS=Bos taurus OX=9913 GN=EHD1 PE=4 SV=1 CANONICAL=A0AAF7AFD7-1" }, "locus": { "chromosome": "29", "start_pos": 43104841, "end_pos": 43084617, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083276.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083276.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068009.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068009.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "low-density lipoprotein particle clearance", "id": "GO:0034383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034383", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "positive regulation of endocytic recycling", "id": "GO:2001137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001137", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "positive regulation of myoblast fusion", "id": "GO:1901741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901741", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "positive regulation of cholesterol storage", "id": "GO:0010886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010886", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "platelet dense tubular network membrane", "id": "GO:0031095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031095", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" }, { "name": "ciliary pocket membrane", "id": "GO:0020018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020018", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AFD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AFD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" }, { "id": "PS51718", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51718" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dynamin-type G", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 303, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF7AFD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 493, "end_pos": 528, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF7AFD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AFD7" }, { "id": "PS50031", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50031" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EH", "eco_id": "ECO_0000259", "start_pos": 461, "end_pos": 549, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBB9-1", "uniprot_ac": "E1BBB9", "uniprot_id": "E1BBB9_BOVIN", "mass": { "chemical_mass": 55872.0, "monoisotopic_mass": 55872.0 }, "refseq": { "ac": "XP_059747567", "name": "zinc finger protein 79 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747567" }, "gene_names": [ { "name": "ZNF79", "type": "recommended", "evidence": [ { "id": "E1BBB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ] }, { "name": "ZNF79", "type": "synonym", "evidence": [ { "id": "XP_059747567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747567" } ] } ], "protein_names": [ { "name": "Zinc finger protein 79", "type": "synonym", "evidence": [ { "id": "E1BBB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB9/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 79 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059747567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747567" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9TWD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF79", "url": "https://www.uniprot.org/uniprotkb/E1BBB9", "locus": { "chromosome": "11", "start_pos": 98178722, "end_pos": 98162344, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023885", "url": "https://www.ensembl.org/id/ENSBTAG00000023885" } ] } } ], "crossref": [ { "id": "E1BBB9", "url": "https://alphafold.ebi.ac.uk/entry/E1BBB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023885", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023885", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614564", "url": "https://www.ncbi.nlm.nih.gov/gene/614564", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614564", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614564", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKIMSES", "url": "https://omabrowser.org/oma/group/WKIMSES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818:SF158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818:SF158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF85", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF85", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24409", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24409", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24409:SF331", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24409:SF331", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059747567", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEEGEPPSPDPALLQEEDTEEEGMAAGLLTAGPQGSTPFSNVTVDFTQGGWRQLAPAPRDRFEEGMPENSRNLVLLGLPVSQPGMNSQLEQREGSWMLERDGLRNACPDWKIISESPPEQDISEESFQDPSVEMPSGVSEHRNSELGKSLNMRPVLSPQQRVPTEVRSHKCDTHAESFGNNAGTVKLHRVKPYTCNECGKAFSYCSSLSQHQKSHTGEKPYECNECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYKCTECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCRECGKAFSYCAAFIQHQRIHTGEKPYKCNACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNDCGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECRECGKAFRCSSAFIRHQRLHAGE", "length": 499, "header": "tr|E1BBB9-1|E1BBB9_BOVIN Isoform 1 of Zinc finger protein 79 OS=Bos taurus OX=9913 GN=ZNF79 PE=3 SV=3 CANONICAL=E1BBB9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAI9/entry", "sequence": { "sequence": "MLEEGEPPSPDPALLQEEDTEEEGMAAGLLTAGPQGSTPFSNVTVDFTQGGWRQLAPAPRDRFEEGMPENSRNLVLLGLPVSQPGMNSQLEQREGSWMLERDGLRNACPDWKIISESPPEQDISEESFQDPSVEMPSGVSEHRNSELGKSLNMRPVLSPQQRVPTEVRSHKCDTHAESFGNNAGTVKLHRVKPYTCNECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYKCTECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCRECGKAFSYCAAFIQHQRIHTGEKPYKCNACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNDCGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECRECGKAFRCSSAFIRHQRLHAGE", "length": 471, "header": "tr|A0AAA9TAI9-1|E1BBB9_BOVIN Computationally mapped isoform of Zinc finger protein 79 OS=Bos taurus OX=9913 GN=ZNF79 PE=3 SV=1 CANONICAL=E1BBB9-1" }, "locus": { "chromosome": "11", "start_pos": 98177718, "end_pos": 98162679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119045.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119045.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095012.1" } ] } }, { "isoform_ac": "A0AAA9TWD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD0/entry", "sequence": { "sequence": "MQGSTPFSNVTVDFTQGGWRQLAPAPRDRFEEGMPENSRNLVLLGLPVSQPGMNSQLEQREGSWMLERDGLRNACPDWKIISESPPEQDISEESFQDPSVEMPSGVSEHRNSELGKSLNMRPVLSPQQRVPTEVRSHKCDTHAESFGNNAGTVKLHRVKPYTCNECGKAFSYCSSLSQHQKSHTGEKPYECNECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYKCTECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCRECGKAFSYCAAFIQHQRIHTGEKPYKCNACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNDCGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECRECGKAFRCSSAFIRHQRLHAGE", "length": 466, "header": "tr|A0AAA9TWD0-1|E1BBB9_BOVIN Computationally mapped isoform of Zinc finger protein 79 OS=Bos taurus OX=9913 GN=ZNF79 PE=3 SV=1 CANONICAL=E1BBB9-1" }, "locus": { "chromosome": "11", "start_pos": 98177718, "end_pos": 98170175, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113692.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113692.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101759.1" } ] } }, { "isoform_ac": "E1BBB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBB9/entry", "sequence": { "sequence": "MLEEGEPPSPDPALLQEEDTEEEGMAAGLLTAGPQGSTPFSNVTVDFTQGGWRQLAPAPRDRFEEGMPENSRNLVLLGLPVSQPGMNSQLEQREGSWMLERDGLRNACPDWKIISESPPEQDISEESFQDPSVEMPSGVSEHRNSELGKSLNMRPVLSPQQRVPTEVRSHKCDTHAESFGNNAGTVKLHRVKPYTCNECGKAFSYCSSLSQHQKSHTGEKPYECNECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYKCTECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCRECGKAFSYCAAFIQHQRIHTGEKPYKCNACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNDCGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECRECGKAFRCSSAFIRHQRLHAGE", "length": 499, "header": "tr|E1BBB9-1|E1BBB9_BOVIN Isoform 1 of Zinc finger protein 79 OS=Bos taurus OX=9913 GN=ZNF79 PE=3 SV=3 CANONICAL=E1BBB9-1" }, "locus": { "chromosome": "11", "start_pos": 98177718, "end_pos": 98162679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032812.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032812.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032740.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032740.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614564", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614564", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RS18-1", "protein_name": "Zinc finger protein 79", "gene_name": "ZNF79", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLEEEPPSPDLMLPQEEGTEEEGMAAGLLTAGPQGSTPFSSVTVAFTQEGWRQLVPAPRDRFKEGIPEKSRNLVLLGLPVSEPGVNAQLEQRESSWMLEREGLRAACPDWKIVSESPPEQDISEDSFQDPSVDSGESDHRSSELGKGFSLRPVLSPQQRVPTEVRPRKCETHTESFRKNSDIITSHRAKPYTCNECGKAFSYCSSLSQHQKSHTGEKPYECNECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYKCSECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCSECGKAFSYCAAFIQHQRIHTGEKPYKCSACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNECGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECSECGKAFRCSSAFIRHQRLHAGE", "length": 496 }, "evidence": [ { "id": "E1BBB9", "url": "https://omabrowser.org/oma/group/E1BBB9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15937-1", "protein_name": "Zinc finger protein 79", "gene_name": "ZNF79", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLEEGVLPSPGPALPQEENTGEEGMAAGLLTAGPRGSTFFSSVTVAFAQERWRCLVSTPRDRFKEGIPGKSRSLVLLGLPVSQPGMNSQLEQREGAWMLEGEDLRSPSPGWKIISGSPPEQALSEASFQDPCVEMPPGDSDHGTSDLEKSFNLRPVLSPQQRVPVEARPRKCETHTESFKNSEILKPHRAKPYACNECGKAFSYCSSLSQHQKSHTGEKPYECSECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYRCSECEKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCSECGKAFSYCAAFIQHQRIHTGEKPYRCAACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNECGKFFSESSALIRHHIIHTGEKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECSECGKAFRCSSAFVRHQRLHAGE", "length": 498 }, "evidence": [ { "id": "E1BBB9", "url": "https://omabrowser.org/oma/group/E1BBB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BBB9", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 499, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBB9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 221, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB9" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 109, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 264, "end_pos": 266 }, { "start_pos": 320, "end_pos": 322 }, { "start_pos": 376, "end_pos": 378 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 456, "end_pos": 458 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBD1-1", "uniprot_ac": "E1BBD1", "uniprot_id": "E1BBD1_BOVIN", "mass": { "chemical_mass": 36836.0, "monoisotopic_mass": 36836.0 }, "refseq": {}, "gene_names": [ { "name": "C23H6orf15", "type": "recommended", "evidence": [ { "id": "E1BBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD1" } ] } ], "protein_names": [ { "name": "Chromosome 23 C6orf15 homolog", "type": "synonym", "evidence": [ { "id": "E1BBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBD1", "url": "https://www.uniprot.org/uniprotkb/E1BBD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C23H6orf15", "url": "https://www.uniprot.org/uniprotkb/E1BBD1", "locus": { "chromosome": "23", "start_pos": 28030854, "end_pos": 28028313, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004539", "url": "https://www.ensembl.org/id/ENSBTAG00000004539" } ] } } ], "crossref": [ { "id": "E1BBD1", "url": "https://alphafold.ebi.ac.uk/entry/E1BBD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004539", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004539", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788708", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788708", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WPSEDPW", "url": "https://omabrowser.org/oma/group/WPSEDPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBD1", "url": "https://www.orthodb.org/?gene=E1BBD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15817:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15817:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15809", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15809", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BBD1", "url": "https://www.uniprot.org/uniprotkb/E1BBD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQGCVVGKRAPLGLLLVCLHLPGLLARSIGVMEEKVPRDLGISLPLLGPSPLTGPSNAEHPQPKPAPGPNDLARAALKPNPSPPHGSQPVGGPGVQGWPRSGGLLSMDSWPSEDPWPMLAAAVEDHVGEVLPGELSYLSRVAALPVGSRPWPAGPSAHPGDPSPESSLFHRDSESRRPFRPNVLGSLGDILARSPLWALINRIRRPLLPGHPWGTLNPSTSWGGGGPGSGWGTRPMPYPVGIWGNTHQYPSTSWGNIPLYPGINQFPPRILRPPGSSWSIPAGFPSPQNPGASWSHLGQVGELAPLSWTLKGGGRAAGLTGMAPVAGGKDEVQVGSECPFIQRHRGSEKVI", "length": 351, "header": "tr|E1BBD1-1|E1BBD1_BOVIN Isoform 1 of Chromosome 23 C6orf15 homolog OS=Bos taurus OX=9913 GN=C23H6orf15 PE=4 SV=2 CANONICAL=E1BBD1-1" }, "isoforms": [ { "isoform_ac": "E1BBD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBD1/entry", "sequence": { "sequence": "MQGCVVGKRAPLGLLLVCLHLPGLLARSIGVMEEKVPRDLGISLPLLGPSPLTGPSNAEHPQPKPAPGPNDLARAALKPNPSPPHGSQPVGGPGVQGWPRSGGLLSMDSWPSEDPWPMLAAAVEDHVGEVLPGELSYLSRVAALPVGSRPWPAGPSAHPGDPSPESSLFHRDSESRRPFRPNVLGSLGDILARSPLWALINRIRRPLLPGHPWGTLNPSTSWGGGGPGSGWGTRPMPYPVGIWGNTHQYPSTSWGNIPLYPGINQFPPRILRPPGSSWSIPAGFPSPQNPGASWSHLGQVGELAPLSWTLKGGGRAAGLTGMAPVAGGKDEVQVGSECPFIQRHRGSEKVI", "length": 351, "header": "tr|E1BBD1-1|E1BBD1_BOVIN Isoform 1 of Chromosome 23 C6orf15 homolog OS=Bos taurus OX=9913 GN=C23H6orf15 PE=4 SV=2 CANONICAL=E1BBD1-1" }, "locus": { "chromosome": "23", "start_pos": 28030840, "end_pos": 28029202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005965.4", "url": "https://www.ensembl.org/id/ENSBTAT00000005965.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005965.2", "url": "https://www.ensembl.org/id/ENSBTAP00000005965.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788708", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788708", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0ZFG5-1", "protein_name": "Chromosome 7 C6orf15 homolog", "gene_name": "C6orf15", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQSRMQGGLAGSWAPLGLLLACLHLPGLFARSISVAEEKVSRDVGVNLPLPGQPSLTGPSNSEHPPPKPDLDPNDLAKASLKPDASPSFDSLLAGGSGVQRWPPSGGLPSEDSWSSEDPWPMMAAAAEDHVGEVLPEELSYLSSGFALPRGGGPVPPHSADPSAEASLLHQDSESRRLPRSNVLGARGEILARHPLWSLINRIRRPFLPGYPWGTLSPSVSWGGGGPGTGWGTRPMPYPVGSWGNSNQYPSTSWGTINRYPGISWGNILRYPGINQFPPRVLRPPGSSWSIPAGFPNPQNPGSQWS", "length": 306 }, "evidence": [ { "id": "E1BBD1", "url": "https://omabrowser.org/oma/group/E1BBD1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6UXA7-1", "protein_name": "Uncharacterized protein C6orf15", "gene_name": "C6orf15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQGRVAGSCAPLGLLLVCLHLPGLFARSIGVVEEKVSQNLGTNLPQLGQPSSTGPSNSEHPQPALDPRSNDLARVPLKLSVPASDGFPPAGGSAVQRWPPSWGLPAMDSWPPEDPWQMMAAAAEDRLGEALPEELSYLSSAAALAPGSGPLPGESSPDATGLSPKASLLHQDSESRRLPRSNSLGAGGKILSQRPPWSLIHRVLPDHPWGTLNPSVSWGGGGPGTGWGTRPMPHPEGIWGINNQPPGTSWGNINRYPGGSWGNINRYPGGSWGNINRYPGGSWGNIHLYPGINNPFPPGVLRPPGSSWNIPAGFPNPPSPRLQWG", "length": 325 }, "evidence": [ { "id": "E1BBD1", "url": "https://omabrowser.org/oma/group/E1BBD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BM15-1", "protein_name": "Uncharacterized protein C6orf15 homolog", "gene_name": "Stg", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQSHAGGSRAPLGLLLICLCLPGLFARSTGAPEEKASPHSGQPSFTSLLNPGQPQPKPDPVNNELLGVLPRLSESPQDGALPEGGSEVPNGPPFWGPPPMESWPSEDPQQGMAAVAEDQLEQMLPEALPYLSRGGRLPEASSARLRQPSLAASYPQDSEAGLQPGSSSLETEAEAFARSPFWFLIHKLLPGSSGRILRPGTSWGSGGAGTGWGTRPMPYPSGIWGSNGLVSGTSLGGRGPYPVRIWGRNGWYPLRILGGNGRYPPVGTWGGYGQYPPVGTWGGYGQYPPVGPWGGYGQYPPVGTWGANCQYPAGSRRPNCRYPAGSWGTKGQNRLPPGAKRPGSSGITP", "length": 349 }, "evidence": [ { "id": "E1BBD1", "url": "https://omabrowser.org/oma/group/E1BBD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "E1BBD1", "url": "https://www.uniprot.org/uniprotkb/E1BBD1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BBD1", "url": "https://www.uniprot.org/uniprotkb/E1BBD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0T3-1", "uniprot_ac": "F1N0T3", "uniprot_id": "F1N0T3_BOVIN", "mass": { "chemical_mass": 42593.0, "monoisotopic_mass": 42593.0 }, "refseq": { "ac": "XP_010816933", "name": "serpin B6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816933" }, "gene_names": [ { "name": "LOC617406", "type": "recommended", "evidence": [ { "id": "F1N0T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T3" } ] }, { "name": "LOC617406", "type": "synonym", "evidence": [ { "id": "XP_010816933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816933" } ] } ], "protein_names": [ { "name": "Serpin B6", "type": "recommended", "evidence": [ { "id": "F1N0T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T3/entry#names_and_taxonomy" } ] }, { "name": "serpin B6", "type": "synonym", "evidence": [ { "id": "XP_010816933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816933" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0T3", "url": "https://www.uniprot.org/uniprotkb/F1N0T3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC617406", "url": "https://www.uniprot.org/uniprotkb/F1N0T3", "locus": {} } ], "crossref": [ { "id": "F1N0T3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0T3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049906", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049906", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19565", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19565", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617406", "url": "https://www.ncbi.nlm.nih.gov/gene/617406", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617406", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617406", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSCCKFY", "url": "https://omabrowser.org/oma/group/DSCCKFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0T3", "url": "https://www.orthodb.org/?gene=F1N0T3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF204", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF204", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75205", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75205", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010816933", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816933", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0T3", "url": "https://www.uniprot.org/uniprotkb/F1N0T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0T3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0T3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDALSEANGTFALTLLKKLGEGSSENVFISPLSISSALAMVLMGARGNTAAQMCQTLSLNKSSGGGEDVHQGFQNLLSEVNRTDTQYLLRTANRLFGEKTYDFLSSFKDSCRIFYQAEMEELDFLSATEESRKHINTWVAEKTEGKIRDLLPANSVNAMTRLVLVNAIYFKGNWDTQFNKEHTKERPFRVSKNMEKPVQMMFKKSTFKSTYIGEISTQILVLPYVGKELNMVILLPSESTDLNTVEKALTYEKFVTWTKLDVMDEDEVEVFLPRFTLEESYDMECVLRDLGVTDAFEAAQADFSGMSCQQDLHLSKIVHKSFVEVTEEGTEAAAATVARITPRILRIVPRFCADHPFLFFIQHSRTGAILFCGRFCSP", "length": 378, "header": "tr|F1N0T3-1|F1N0T3_BOVIN Isoform 1 of Serpin B6 OS=Bos taurus OX=9913 GN=LOC617406 PE=3 SV=2 CANONICAL=F1N0T3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG9/entry", "sequence": { "sequence": "MAGSAQPLPLCPHLPSSAQPRPSSPGIWAPAPPSLPSLFLPCLVRVGRWGRGTGLPEAEGSGLGGGWHRAGFPFGPGGAVDVTTHLATMDALSEANGTFALTLLKKLGEGSSENVFISPLSISSALAMVLMGARGNTAAQMCQTLSLNKSSGGGEDVHQGFQNLLSEVNRTDTQYLLRTANRLFGEKTYDFLSSFKDSCRIFYQAEMEELDFLSATEESRKHINTWVAEKTEGKIRDLLPANSVNAMTRLVLVNAIYFKGNWDTQFNKEHTKERPFRVSKNMEKPVQMMFKKSTFKSTYIGEISTQILVLPYVGKELNMVILLPSESTDLNTVEKALTYEKFVTWTKLDVMDEDEVEVFLPRFTLEESYDMECVLRDLGVTDAFEAAQADFSGMSCQQDLHLSKIVHKSFVEVTEEGTEAAAATVARITPRILRIVPRFCADHPFLFFIQHSRTGAILFCGRFCSP", "length": 466, "header": "tr|A0AAA9TDG9-1|F1N0T3_BOVIN Computationally mapped isoform of Serpin B6 OS=Bos taurus OX=9913 GN=LOC617406 PE=3 SV=1 CANONICAL=F1N0T3-1" }, "locus": { "chromosome": "23", "start_pos": 50667260, "end_pos": 50648864, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130817.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130817.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096168.1" } ] } }, { "isoform_ac": "F1N0T3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0T3/entry", "sequence": { "sequence": "MDALSEANGTFALTLLKKLGEGSSENVFISPLSISSALAMVLMGARGNTAAQMCQTLSLNKSSGGGEDVHQGFQNLLSEVNRTDTQYLLRTANRLFGEKTYDFLSSFKDSCRIFYQAEMEELDFLSATEESRKHINTWVAEKTEGKIRDLLPANSVNAMTRLVLVNAIYFKGNWDTQFNKEHTKERPFRVSKNMEKPVQMMFKKSTFKSTYIGEISTQILVLPYVGKELNMVILLPSESTDLNTVEKALTYEKFVTWTKLDVMDEDEVEVFLPRFTLEESYDMECVLRDLGVTDAFEAAQADFSGMSCQQDLHLSKIVHKSFVEVTEEGTEAAAATVARITPRILRIVPRFCADHPFLFFIQHSRTGAILFCGRFCSP", "length": 378, "header": "tr|F1N0T3-1|F1N0T3_BOVIN Isoform 1 of Serpin B6 OS=Bos taurus OX=9913 GN=LOC617406 PE=3 SV=2 CANONICAL=F1N0T3-1" }, "locus": { "chromosome": "23", "start_pos": 50663424, "end_pos": 50648864, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023242.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023242.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023242.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023242.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617406", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617406", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-75205", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75205", "resource": "Reactome", "description": "Dissolution of Fibrin Clot" } ], "orthologs": [ { "uniprot_canonical_ac": "P35237-1", "protein_name": "Serpin B6", "gene_name": "SERPINB6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP", "length": 376 }, "evidence": [ { "id": "F1N0T3", "url": "https://omabrowser.org/oma/group/F1N0T3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "F1N0T3", "url": "https://www.uniprot.org/uniprotkb/F1N0T3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N0T3", "url": "https://www.uniprot.org/uniprotkb/F1N0T3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0T3", "url": "https://www.uniprot.org/uniprotkb/F1N0T3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T3" }, { "id": "SM00093", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serpin", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 378, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 60, "end_pos": 62 }, { "start_pos": 81, "end_pos": 83 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7S9-1", "uniprot_ac": "E1B7S9", "uniprot_id": "E1B7S9_BOVIN", "mass": { "chemical_mass": 30106.0, "monoisotopic_mass": 30106.0 }, "refseq": { "ac": "XP_024845830", "name": "TLC domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845830" }, "gene_names": [ { "name": "TLCD4", "type": "recommended", "evidence": [ { "id": "E1B7S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S9" } ] }, { "name": "TLCD4", "type": "synonym", "evidence": [ { "id": "XP_024845830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845830" } ] } ], "protein_names": [ { "name": "TLC domain containing 4", "type": "synonym", "evidence": [ { "id": "E1B7S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S9/entry#names_and_taxonomy" } ] }, { "name": "TLC domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "XP_024845830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845830" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7S9", "url": "https://www.uniprot.org/uniprotkb/E1B7S9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TLCD4", "url": "https://www.uniprot.org/uniprotkb/E1B7S9", "locus": { "chromosome": "3", "start_pos": 48292379, "end_pos": 48358012, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044125", "url": "https://www.ensembl.org/id/ENSBTAG00000044125" } ] } } ], "crossref": [ { "id": "E1B7S9", "url": "https://alphafold.ebi.ac.uk/entry/E1B7S9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044125", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044125", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614522", "url": "https://www.ncbi.nlm.nih.gov/gene/614522", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614522", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614522", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPVYYSH", "url": "https://omabrowser.org/oma/group/MPVYYSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7S9", "url": "https://www.orthodb.org/?gene=E1B7S9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13439", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13439", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13439:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13439:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845830", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845830", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S9", "url": "https://www.uniprot.org/uniprotkb/E1B7S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTNTILLISTCFASFFTFQIIFHVVSYWFSAKISPGFNNLNFKKKIEWNSRVVSTCHSLVVGLVGLYIFLFDEAGIADPLWGDTSLGKVNVAIASGYLVSDLLILIWYWKVIGDKYFVIHHCTALYAYHFVLNDGVLVYVGNFRLLAELSSPFVNQRWFFEALKYPKFSKANVINGILMTVVFFVVRIASIPPYYGYMYSVFGTEAYMRLGFLIQFSWISTCVVLDVMNVMWMIKISKGCIKVISLLRQEKARKSLQNGKLD", "length": 263, "header": "tr|E1B7S9-1|E1B7S9_BOVIN Isoform 1 of TLC domain containing 4 OS=Bos taurus OX=9913 GN=TLCD4 PE=4 SV=3 CANONICAL=E1B7S9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TFT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT5/entry", "sequence": { "sequence": "MDTNTILLISTCFASFFTFQIIFHVVSYWFSAKISPGFNNLNFKKKIEWNSRVVSTCHSLVVGLVGLYIFLFDEAGIADPLWGDTSLGKVNVAIASGYLVSDLLILIWYWKVIGDKYFVIHHCTALYAYHFVLLSHKGSHSQLWSSLVAQKNDGVLVYVGNFRLLAELSSPFVNQRWFFEALKYPKFSKANVINGILMTVVFFVVRIASIPPYYGYMYSVFGTEAYMRLGFLIQFSWISTCVVLDVMNVMWMIKISKGCIKVISLLRQEKARKSLQNGKLD", "length": 281, "header": "tr|A0AAA9TFT5-1|E1B7S9_BOVIN Computationally mapped isoform of TLC domain containing 4 OS=Bos taurus OX=9913 GN=TLCD4 PE=4 SV=1 CANONICAL=E1B7S9-1" }, "locus": { "chromosome": "3", "start_pos": 48334791, "end_pos": 48293383, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096141.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096141.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095879.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095879.1" } ] } }, { "isoform_ac": "E1B7S9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S9/entry", "sequence": { "sequence": "MDTNTILLISTCFASFFTFQIIFHVVSYWFSAKISPGFNNLNFKKKIEWNSRVVSTCHSLVVGLVGLYIFLFDEAGIADPLWGDTSLGKVNVAIASGYLVSDLLILIWYWKVIGDKYFVIHHCTALYAYHFVLNDGVLVYVGNFRLLAELSSPFVNQRWFFEALKYPKFSKANVINGILMTVVFFVVRIASIPPYYGYMYSVFGTEAYMRLGFLIQFSWISTCVVLDVMNVMWMIKISKGCIKVISLLRQEKARKSLQNGKLD", "length": 263, "header": "tr|E1B7S9-1|E1B7S9_BOVIN Isoform 1 of TLC domain containing 4 OS=Bos taurus OX=9913 GN=TLCD4 PE=4 SV=3 CANONICAL=E1B7S9-1" }, "locus": { "chromosome": "3", "start_pos": 48334791, "end_pos": 48293383, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060965.5", "url": "https://www.ensembl.org/id/ENSBTAT00000060965.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053163.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053163.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614522", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614522", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AN10-1", "protein_name": "TLC domain containing 4", "gene_name": "TLCD4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDTSSTLVISIVIIGFFTFQLLFHFVSSWFSAKVSPGFNNLNFKKKIEWNSRVVSTCHSLVVGVVGLYIFWFDEATIADPLWGDPSFVKVNIAVSSSYLISDLFILILYWKVIGDKYYIIHHCTALYAYYFILSEGVLAYIGNFRLLAELSTPFVNQRWFFEALSYPRVSKAYVINGVLMTAVFFVMRIASIPPLYAYIYSVLGTEAYRRLGALIQCSWISSCVVLDVMNVMWMVKISKGCIKVISLFRQEKARRSLQNGKLD", "length": 263 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M2B9S8-1", "protein_name": "TLC domain-containing protein 4 isoform X1", "gene_name": "tlcd4a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEGMSVKHLLYFSPGAWGRVAMDPFSQLILLISVVSFFFFQWLFHSVSPWASSRISPGFLKLTHKQKIEWNSRTVSTLHALLVGLFCLYILFFDEAVNQDPVWGDPTLVKINVSITTGYLISDLLLIFYYWRAIGDKFFVIHHLAALYAYYYVLGQGMLPYFANFRLLAEFSTPCVNQRWFFEVLGYPKSSRPNMANGVLMAAVFFLVRIAVMPVYYSRMCSVYGTEAFYRVSFGGRSAWIFSSICLDIMNVMWMHKIFRGCYKVLQSSRKSKAESQENGKTD", "length": 284 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZGI5-1", "protein_name": "TLC domain containing 4", "gene_name": "TLCD4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASFSNLTIGIALASFTIFQLLFHVLSSWVSTRITPGFSNLSQKRKIEWNSRTVSTFHALVVGGFCLYILLYDEAVNADHLWGDPSIVKLNIAITTGYLISDLLLIICYWKAIGDKFFVVHHLAALYAYYFVLSKGLLAYFGNFRLLAEFSTPFVNQRWFFEVLGYPKSSKANMINGVLMTVVFFVVRIAVMPMYYSRVFSSFGTEGFQRLGFAAQSAWIISSVVLDVMNLMWMAKITKGCYKVICLVGREEAKTHKNGKSD", "length": 262 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7J9G9-1", "protein_name": "TLC domain-containing protein 4", "gene_name": "LOC100772772", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEANTKLVIGIVCSSFVIFQILFHFVSYWFSAKVSPGYNSLSIEKKIEWNSRVVSTCHSLLVGTYGLYLFLFDEPTIADPLWGDPACVKLNIATASGYLVSDLLIILLNWKVIGDKFFVIHHCAALTAYFLMLRDGVLAYIANFRLLAELSSPFVNQRWFFETLKYPKFSKANVINGILMTVVFFVVRIIAIPPLYFFIYSVYGTEAFIRLGFTIQFTWITTCLILDVMNVMWMIKITKGCIKVISLIRQEKAKNSLQNGKLD", "length": 263 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4AAE5-1", "protein_name": "TLC domain containing 4", "gene_name": "Tlcd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEANTNVVIGTVCCSFVTFQLLFHFISCWFSARVSLGYNSLSTEKKIEWNSRVVSTCHSMLVGIFGLYLFFFDEATIADPLWGDPSLVKINISTASGYLISDLLIILFNWKVIGDKFFIIHHCAGLIAYYFVLKIGVLAYIANFRLLAELSSPFVNQRWFFEVLKYPKFSKVNVINGILMTVVFFIVRIIAIPPMYFYVYSVYGTEPYIRLGSVVHFVWISSCIVLDVMNIMWMIKITKGCMKVISLIRQEKAKDSLQNGKLD", "length": 263 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47153-1", "protein_name": "Topoisomerase I damage affected protein 4", "gene_name": "TDA4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNANSTTTAIGLTSPFEKLSFFPHSSNLILAHLHEIIFSFVFYQLAFSVVAPFLNKVVFRKHYTTIRDPLLKIDFNVHTVSMIQAVVSNTVLLPTLTTPMHYNVVTYTDSYSSMVSSLSAGYFIWDLTMCVRYFKLYGLEFTGHAIGSVYVMLLSLRPFCQPWIGRFLIYEASTPFVNINWFIMQCNAKSKNSIPLWFNVVNGLLLMTVFFVVRICWGSIASALLFRQMWKVRDELPKFSAVTMMSLNIFMNLLNVLWFKKMIRIAKKLAKPAPTSKLD", "length": 279 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8CGF5-1", "protein_name": "TLC domain-containing protein 4", "gene_name": "Tlcd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASTKAAVGSGAMEASTKAVICTVCSSFVVFQILFHFVSYWFSARVSSGYNSLSIDKKIEWNSRVVSTCHSLLVGIFGLYLFFFDEATITDPLWGDPTYVNINIATASGYLISDLLIILFNWKVIGDKFFIIHHCAGLTAYYFVLTTGALAYIANFRLLAELSSPFVNQRWFFEALKYPKFSKANVINGILMTVVFFIVRIISIPPMYFFLYSVYGTEPYIRFGFVIQSVWIVTCVILDVMNIMWMIKITKGCIKVISLIRQEKAKDSLQNGKLD", "length": 276 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96MV1-1", "protein_name": "TLC domain-containing protein 4", "gene_name": "TLCD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEINTKLLISVTCISFFTFQLLFYFVSYWFSAKVSPGFNSLSFKKKIEWNSRVVSTCHSLVVGIFGLYIFLFDEATKADPLWGGPSLANVNIAIASGYLISDLSIIILYWKVIGDKFFIMHHCASLYAYYLVLKNGVLAYIGNFRLLAELSSPFVNQRWFFEALKYPKFSKAIVINGILMTVVFFIVRIASMLPHYGFMYSVYGTEPYIRLGVLIQLSWVISCVVLDVMNVMWMIKISKGCIKVISHIRQEKAKNSLQNGKLD", "length": 263 }, "evidence": [ { "id": "E1B7S9", "url": "https://omabrowser.org/oma/group/E1B7S9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7S9", "url": "https://www.uniprot.org/uniprotkb/E1B7S9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B7S9", "url": "https://www.uniprot.org/uniprotkb/E1B7S9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "E1B7S9", "url": "https://www.uniprot.org/uniprotkb/E1B7S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7S9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 263, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7S9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7S9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S9" }, { "id": "PS50922", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50922" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TLC", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 246, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCG0-1", "uniprot_ac": "E1BCG0", "uniprot_id": "E1BCG0_BOVIN", "mass": { "chemical_mass": 62144.0, "monoisotopic_mass": 62144.0 }, "refseq": {}, "gene_names": [ { "name": "C3H1orf87", "type": "recommended", "evidence": [ { "id": "E1BCG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCG0" } ] } ], "protein_names": [ { "name": "Chromosome 3 C1orf87 homolog", "type": "synonym", "evidence": [ { "id": "E1BCG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCG0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCG0", "url": "https://www.uniprot.org/uniprotkb/E1BCG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C3H1orf87", "url": "https://www.uniprot.org/uniprotkb/E1BCG0", "locus": { "chromosome": "3", "start_pos": 85786695, "end_pos": 85704993, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009481", "url": "https://www.ensembl.org/id/ENSBTAG00000009481" } ] } } ], "crossref": [ { "id": "E1BCG0", "url": "https://alphafold.ebi.ac.uk/entry/E1BCG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009481", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009481", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR34830", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34830", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34830:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34830:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9THF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCG0", "url": "https://www.uniprot.org/uniprotkb/E1BCG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCG0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSVWKTPRGSNAMPEMMVKIIGSKHFRYLVEKPKIKENQNLKAETQTVLQKSVTGDAKPIGGDPPALTDPTDHQINHDPDDVKESKHQENNQKPEDNGKLLTGALSCRFLDGKVSNQANVYCISQPTGDQSLSYIHGLPRRNFRDWSLEQMARSSSDQPKDIGQRPSGTKKEDTFLLALVRRELKSLPLSSGLLDKLQKELKVLDPVSSGFLLQSQLSHLFLRLEVPLQLPTVKILCQRFSRGSSPEMVNYEKLLWFLKVAASEDTEQNKGVEDSNVKETQSSSHQSLSPASPSSIAPQDYNSQSEVNESLLEVLKMALRATKAKLNIEKLNLSFRKEDRSFSGCLPPPKVRAICGKHGLYLTLSLLETLLNHQDLGYQNEIKWENFVEWLGRASSDLSSDFPPGNKGKEISATPGHPEAPEISQGETEQMKTPEKDLKPENPPAETSAPKDILNALKIRPISQPSVSPVMKNAAEECETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLSPRKIDQALRSFCAGENMLLEPALRYLKEL", "length": 554, "header": "tr|E1BCG0-1|E1BCG0_BOVIN Isoform 1 of Chromosome 3 C1orf87 homolog OS=Bos taurus OX=9913 GN=C3H1orf87 PE=4 SV=4 CANONICAL=E1BCG0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF9/entry", "sequence": { "sequence": "MSSVWKTPRGSNAMPEMMVKIIGSKHFRYLVEKPKIKENQNLKAETQTVLQKSVTGDAKPIGGDPPALTDPTDHQINHDPDDVKESKHQENNQKPEDNGKLLTGALSCRFLDGKVRAICGKHGLYLTLSLLETLLNHQDLGYQNEIKWENFVEWLGRASSDLSSDFPPGNKGKEISATPGHPEAPEISQGETEQMKTPEKDLKPENPPAETSAPKDILNALKIRPISQPSVSPVMKNAAEECETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLSPRKIDQALRSFCAGENMLLEPALRYLKEL", "length": 317, "header": "tr|A0AAA9THF9-1|E1BCG0_BOVIN Computationally mapped isoform of Chromosome 3 C1orf87 homolog OS=Bos taurus OX=9913 GN=C3H1orf87 PE=4 SV=1 CANONICAL=E1BCG0-1" }, "locus": { "chromosome": "3", "start_pos": 85785946, "end_pos": 85706264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107384.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107384.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096306.1" } ] } }, { "isoform_ac": "E1BCG0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCG0/entry", "sequence": { "sequence": "MSSVWKTPRGSNAMPEMMVKIIGSKHFRYLVEKPKIKENQNLKAETQTVLQKSVTGDAKPIGGDPPALTDPTDHQINHDPDDVKESKHQENNQKPEDNGKLLTGALSCRFLDGKVSNQANVYCISQPTGDQSLSYIHGLPRRNFRDWSLEQMARSSSDQPKDIGQRPSGTKKEDTFLLALVRRELKSLPLSSGLLDKLQKELKVLDPVSSGFLLQSQLSHLFLRLEVPLQLPTVKILCQRFSRGSSPEMVNYEKLLWFLKVAASEDTEQNKGVEDSNVKETQSSSHQSLSPASPSSIAPQDYNSQSEVNESLLEVLKMALRATKAKLNIEKLNLSFRKEDRSFSGCLPPPKVRAICGKHGLYLTLSLLETLLNHQDLGYQNEIKWENFVEWLGRASSDLSSDFPPGNKGKEISATPGHPEAPEISQGETEQMKTPEKDLKPENPPAETSAPKDILNALKIRPISQPSVSPVMKNAAEECETWIDRFRKLENALYLCDLSNTGVLEKERARRLIHNYNLIYNLSLSPRKIDQALRSFCAGENMLLEPALRYLKEL", "length": 554, "header": "tr|E1BCG0-1|E1BCG0_BOVIN Isoform 1 of Chromosome 3 C1orf87 homolog OS=Bos taurus OX=9913 GN=C3H1orf87 PE=4 SV=4 CANONICAL=E1BCG0-1" }, "locus": { "chromosome": "3", "start_pos": 85785946, "end_pos": 85706264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012479.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012479.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012479.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012479.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 415, "start_aa": "Thr", "end_pos": 415, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr415", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E1BCG0", "url": "https://www.uniprot.org/uniprotkb/E1BCG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCG0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 554, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCG0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCG0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCG0" }, { "id": "PF17743", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17743" }, { "id": "PF20742", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20742" }, { "id": "PF20743", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20743" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF5580", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 266, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 415 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 309, "end_pos": 311 }, { "start_pos": 333, "end_pos": 335 }, { "start_pos": 521, "end_pos": 523 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBH5-1", "uniprot_ac": "E1BBH5", "uniprot_id": "E1BBH5_BOVIN", "mass": { "chemical_mass": 16695.0, "monoisotopic_mass": 16695.0 }, "refseq": { "ac": "NP_001193061", "name": "tetratricopeptide repeat protein 32", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193061" }, "gene_names": [ { "name": "TTC32", "type": "recommended", "evidence": [ { "id": "E1BBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBH5" } ] }, { "name": "TTC32", "type": "synonym", "evidence": [ { "id": "NP_001193061", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193061" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 32", "type": "synonym", "evidence": [ { "id": "E1BBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBH5/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 32", "type": "synonym", "evidence": [ { "id": "NP_001193061", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193061" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBH5", "url": "https://www.uniprot.org/uniprotkb/E1BBH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC32", "url": "https://www.uniprot.org/uniprotkb/E1BBH5", "locus": { "chromosome": "11", "start_pos": 78910954, "end_pos": 78904244, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015587", "url": "https://www.ensembl.org/id/ENSBTAG00000015587" } ] } } ], "crossref": [ { "id": "E1BBH5", "url": "https://alphafold.ebi.ac.uk/entry/E1BBH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "525750", "url": "https://www.ncbi.nlm.nih.gov/gene/525750", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525750", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525750", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEEDNSQ", "url": "https://omabrowser.org/oma/group/MEEDNSQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBH5", "url": "https://www.orthodb.org/?gene=E1BBH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47059", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47059", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47059:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47059:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193061", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TIZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBH5", "url": "https://www.uniprot.org/uniprotkb/E1BBH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBH5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGQQGQESPAALALAQAHFKKGEYAEAEALYSAYIRQCACAASEGAARGSKCSPEDLATAFNNRGQIKYFRVDFYEAMDDYTSAIEVQPSFEVPYYNRGLILYRLGYFDDALEDFKKALDLNPGFQDAVLSLKQTILDKEEKQRRNY", "length": 148, "header": "tr|E1BBH5-1|E1BBH5_BOVIN Isoform 1 of Tetratricopeptide repeat domain 32 OS=Bos taurus OX=9913 GN=TTC32 PE=4 SV=1 CANONICAL=E1BBH5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ9/entry", "sequence": { "sequence": "MDGQQGQESPAALALAQAHFKKGEYAEAEALYSAYIRQCACAASEGAARGRIL", "length": 53, "header": "tr|A0AAA9TIZ9-1|E1BBH5_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 32 OS=Bos taurus OX=9913 GN=TTC32 PE=4 SV=1 CANONICAL=E1BBH5-1" }, "locus": { "chromosome": "11", "start_pos": 78910255, "end_pos": 78904362, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092315.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092315.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096888.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096888.1" } ] } }, { "isoform_ac": "E1BBH5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBH5/entry", "sequence": { "sequence": "MDGQQGQESPAALALAQAHFKKGEYAEAEALYSAYIRQCACAASEGAARGSKCSPEDLATAFNNRGQIKYFRVDFYEAMDDYTSAIEVQPSFEVPYYNRGLILYRLGYFDDALEDFKKALDLNPGFQDAVLSLKQTILDKEEKQRRNY", "length": 148, "header": "tr|E1BBH5-1|E1BBH5_BOVIN Isoform 1 of Tetratricopeptide repeat domain 32 OS=Bos taurus OX=9913 GN=TTC32 PE=4 SV=1 CANONICAL=E1BBH5-1" }, "locus": { "chromosome": "11", "start_pos": 78910373, "end_pos": 78904362, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020704.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020704.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020704.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020704.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525750", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525750", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XGY2-1", "protein_name": "Tetratricopeptide repeat domain 32", "gene_name": "TTC32", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLREAAAGGTAELLAAAHAQFAARHFAEAEELYSRFIAGGAGRTGRDLATALNNRGQIKYLRVDFDAAMEDYTAAIQSQPAFEVPYYNRGLVLYRLGCFDEAMKDFRKVLELNPQFEDAALSLKQAILDKEEKQKRGY", "length": 138 }, "evidence": [ { "id": "E1BBH5", "url": "https://omabrowser.org/oma/group/E1BBH5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HDJ6-1", "protein_name": "Tetratricopeptide repeat protein 32", "gene_name": "Ttc32", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGPPDRESREKPAALALAQARFARGEFAEAQALYSAFIGQCASRGSKCSPEDLATAYNNRGQTKYFSVDFYEAMDDYTSAIEILPNFEVPYYNRGLIRYRLGYFDEALEDFKKVLDLNPGFQDAVLSLKQTILDKEEKQRRNAEKSY", "length": 148 }, "evidence": [ { "id": "E1BBH5", "url": "https://omabrowser.org/oma/group/E1BBH5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0RDE8-1", "protein_name": "Tetratricopeptide repeat domain 32", "gene_name": "Ttc32", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVPRGRERGESPAALAMAQARFARGDFTEARELYSAFIGQCASHRSKCSPEDLATAYNNRGQTKYFSVDFYEAMDDYTSAIEILPNFEVPYYNRGLIRYRLGYFDEAVEDFKKALDRNPAFQDAVLSLKQTILDKEEKQRRNAQKSY", "length": 148 }, "evidence": [ { "id": "E1BBH5", "url": "https://omabrowser.org/oma/group/E1BBH5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5I0X7-1", "protein_name": "Tetratricopeptide repeat protein 32", "gene_name": "TTC32", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGQRQESHATLTLAQAHFNNGEYAEAEALYSAYIRRCACAASSDESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDLNPGFQDATLSLKQTILDKEEKQRRNVAKNY", "length": 151 }, "evidence": [ { "id": "E1BBH5", "url": "https://omabrowser.org/oma/group/E1BBH5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5TYX3-1", "protein_name": "Tetratricopeptide repeat protein 32", "gene_name": "ttc32", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MENSELKILQKAHEEFNSKNYKRAEELYTQFIESCTKSRDCNGQDLAIAYNNRGQVKYLRVDFYEAMDDYTSAIHINRQFEVPLYNRGLIRYRLGFFKEAEGDFRRVLELNPDFKDAKESLNQTLLDREEKVKRGY", "length": 136 }, "evidence": [ { "id": "E1BBH5", "url": "https://omabrowser.org/oma/group/E1BBH5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9DAC7-1", "protein_name": "Tetratricopeptide repeat protein 32", "gene_name": "Ttc32", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRPGREGGESSAALATAQARFSRGEFAEARELYSAFIGQCARHGSKCSPEDLATAYNNRGQTKYFSVDFYEAMDDYTSAIEILPSFEVPYYNRGLIRYRLGYFDEALEDFKKALDLNPGFQDAVLSLKQTILDKEEKQRRNAEKSY", "length": 148 }, "evidence": [ { "id": "E1BBH5", "url": "https://omabrowser.org/oma/group/E1BBH5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 148, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBH5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9B2-1", "uniprot_ac": "E1B9B2", "uniprot_id": "E1B9B2_BOVIN", "mass": { "chemical_mass": 67675.0, "monoisotopic_mass": 67675.0 }, "refseq": { "ac": "XP_002688894", "name": "zinc finger protein 653 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688894" }, "gene_names": [ { "name": "ZNF653", "type": "recommended", "evidence": [ { "id": "E1B9B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ] }, { "name": "ZNF653", "type": "synonym", "evidence": [ { "id": "XP_002688894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688894" } ] } ], "protein_names": [ { "name": "Zinc finger protein 653", "type": "recommended", "evidence": [ { "id": "E1B9B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B2/entry#names_and_taxonomy" } ] }, { "name": "67 kDa zinc finger protein", "type": "synonym", "evidence": [ { "id": "E1B9B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B2/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein Zip67", "type": "synonym", "evidence": [ { "id": "E1B9B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 653 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002688894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688894" } ] } ], "function": [ { "annotation": "Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2#function" }, { "database": "UniProtKB", "id": "ARBA00054837", "url": "https://www.uniprot.org/uniprotkb/ARBA00054837#function" }, { "database": "UniProtKB", "id": "A0AAA9TJH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJH5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF653", "url": "https://www.uniprot.org/uniprotkb/E1B9B2", "locus": { "chromosome": "7", "start_pos": 15846116, "end_pos": 15862317, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014415", "url": "https://www.ensembl.org/id/ENSBTAG00000014415" } ] } } ], "crossref": [ { "id": "E1B9B2", "url": "https://alphafold.ebi.ac.uk/entry/E1B9B2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014415", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014415", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516232", "url": "https://www.ncbi.nlm.nih.gov/gene/516232", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516232", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516232", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CAVMEGV", "url": "https://omabrowser.org/oma/group/CAVMEGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9B2", "url": "https://www.orthodb.org/?gene=E1B9B2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46179:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46179:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688894", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688894", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TJH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9B2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9B2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAERAPEPEAEAEAEAGAGGEAAAEESAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPESDKVGNGLVAGSSDSSSSGSGSDSEEPPEGQPTKATVATAAVTPTSPAGSSGLITQEGMHIPFDVHHVESLAEQGNPLCPNPASSGPEALETVVCVPVPVQVGPGPGTLFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNMAAGSSAPGGGLGDEVPCAMMEGVAAYTQTEPEGGPPSTMDPAAMTGIETKKEKEDLCVLKKEEKEELVAPEMAELAATVPESAEPDAEADGEELEGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCERCGKRFEKLDSVKFHTLKSHPDHKPA", "length": 618, "header": "tr|E1B9B2-1|E1B9B2_BOVIN Isoform 1 of Zinc finger protein 653 OS=Bos taurus OX=9913 GN=ZNF653 PE=3 SV=2 CANONICAL=E1B9B2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TJH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJH5/entry", "sequence": { "sequence": "MAERAPEPEAEAEAEAGAGGEAAAEESAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPESDKDGDRTESNCWTGWCPGGGRCLTRPARPICWVGNGLVAGSSDSSSSGSGSDSEEPPEGQPTKATVATAAVTPTSPAGSSGLITQEGMHIPFDVHHVESLAEQGNPLCPNPASSGPEALETVVCVPVPVQVGPGPGTLFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNMAAGSSAPGGGLGDEVPCAMMEGVAAYTQTEPEGGPPSTMDPAAMTGIETKKEKEDLCVLKKEEKEELVAPEMAELAATVPESAEPDAEADGEELEGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCERCGKRFEKLDSVKFHTLKSHPDHKPA", "length": 648, "header": "tr|A0AAA9TJH5-1|E1B9B2_BOVIN Computationally mapped isoform of Zinc finger protein 653 OS=Bos taurus OX=9913 GN=ZNF653 PE=3 SV=1 CANONICAL=E1B9B2-1" }, "locus": { "chromosome": "7", "start_pos": 15862118, "end_pos": 15847120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106476.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106476.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097314.1" } ] } }, { "isoform_ac": "E1B9B2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9B2/entry", "sequence": { "sequence": "MAERAPEPEAEAEAEAGAGGEAAAEESAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPESDKVGNGLVAGSSDSSSSGSGSDSEEPPEGQPTKATVATAAVTPTSPAGSSGLITQEGMHIPFDVHHVESLAEQGNPLCPNPASSGPEALETVVCVPVPVQVGPGPGTLFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNMAAGSSAPGGGLGDEVPCAMMEGVAAYTQTEPEGGPPSTMDPAAMTGIETKKEKEDLCVLKKEEKEELVAPEMAELAATVPESAEPDAEADGEELEGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCERCGKRFEKLDSVKFHTLKSHPDHKPA", "length": 618, "header": "tr|E1B9B2-1|E1B9B2_BOVIN Isoform 1 of Zinc finger protein 653 OS=Bos taurus OX=9913 GN=ZNF653 PE=3 SV=2 CANONICAL=E1B9B2-1" }, "locus": { "chromosome": "7", "start_pos": 15862118, "end_pos": 15847120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019173.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019173.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019173.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019173.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 226, "start_aa": "Thr", "end_pos": 226, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr226", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 228, "start_aa": "Thr", "end_pos": 228, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr228", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516232", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516232", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AIY9-1", "protein_name": "Zinc finger protein 653", "gene_name": "ZNF653", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAERAPEPEAEAEAEAEAGAGGEAAAEEGAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPESDKVGNGLVAGSSDSSSSGSSSDSEEPPEGQPAKATVATAAVTPTSPVGSSGLITQEGMHIPFDVHHVENLAEQGTSLCPNPASSGPEALETVVCVPVPVQVGPGPGTLFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNVAAGSSAPGGGLGDEVPCAMMEGVAAYTQTEPPEGSQPSTTDPAAMTGIETKKEKEDLYVLKKEEKEEPMAPELAELAATVPESAEPEAEADGEELDGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCERCGKRFEKLDSVKFHTLKSHPDHKPA", "length": 621 }, "evidence": [ { "id": "E1B9B2", "url": "https://omabrowser.org/oma/group/E1B9B2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZM61-1", "protein_name": "Zinc finger protein 653", "gene_name": "Zfp653", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAERAPEPGAEAAAEEGAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSEPDSDKVGNGLAAGSSDSSSSSSSSDSEEPPETQPAKAPAAAAAVTPSSPTGSSGLITQEGVHIPFDVHHVESLAEQGTPLCQNPAGSGPEALETVVCVPVPMQVGTGPGTLFENMPQEALGEVVASCPVSGMVPGSQVIIIAGPGYDALTAEGIHLNVAAGSGTPSSSLGEEVSCAMMEGVAAYTQTEPEGTQHSTMDTTSIASIETKKDTAPCHPVEKEDLYMLKEEKEDSVAPELAELAATVPENTEAEAEVDGEELDSSEMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCDRCGKRFEKLDSVKFHTLKSHPDHKPA", "length": 615 }, "evidence": [ { "id": "E1B9B2", "url": "https://omabrowser.org/oma/group/E1B9B2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6YND2-1", "protein_name": "Zinc finger protein 653", "gene_name": "Znf653", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAERAPEPGAEAEAGAGGEAAAEEGAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSEPDSDKVGSGLVAGSSDSSSSGSSSDSEEPPETQPAKASAAAAALTPASPTGSSGLITQEGVHIPFDVHHVESLAEQGTPLCQNPAGSGPEALETVVCVPVPMQVGTGPGTLFENMPQEALGEVVASCPVSGMVPGSQVIIIAGPGYDALTAEGIRLNVAAGGGTPSSSLGEEVPCAMMEGVAAYTQTEPEGTQHSTMDTTSIASIETKKEKEDLYMLKEEKEDSVAPELAELAATVPENAEAEAEVDGEELDSSEMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCDRCGKRFEKLDSVKFHTLKSHPDHKPT", "length": 615 }, "evidence": [ { "id": "E1B9B2", "url": "https://omabrowser.org/oma/group/E1B9B2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96CK0-1", "protein_name": "Zinc finger protein 653", "gene_name": "ZNF653", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAERALEPEAEAEAEAGAGGEAAAEEGAAGRKARGRPRLTESDRARRRLESRKKYDVRRVYLGEAHGPWVDLRRRSGWSDAKLAAYLISLERGQRSGRHGKPWEQVPKKPKRKKRRRRNVNCLKNVVIWYEDHKHRCPYEPHLAELDPTFGLYTTAVWQCEAGHRYFQDLHSPLKPLSDSDPDSDKVGNGLVAGSSDSSSSGSASDSEESPEGQPVKAAAAAAAATPTSPVGSSGLITQEGVHIPFDVHHVESLAEQGTPLCSNPAGNGPEALETVVCVPVPVQVGAGPSALFENVPQEALGEVVASCPMPGMVPGSQVIIIAGPGYDALTAEGIHLNMAAGSGVPGSGLGEEVPCAMMEGVAAYTQTEPEGSQPSTMDATAVAGIETKKEKEDLCLLKKEEKEEPVAPELATTVPESAEPEAEADGEELDGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFHCPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCDRCGKRFEKLDSVKFHTLKSHPDHKPT", "length": 615 }, "evidence": [ { "id": "E1B9B2", "url": "https://omabrowser.org/oma/group/E1B9B2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "extracellular negative regulation of signal transduction", "id": "GO:1900116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900116", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "AF-2 domain binding", "id": "GO:0050682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050682", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B9B2", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9B2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 618, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9B2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9B2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 501, "end_pos": 530, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 226, 228 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 588, "end_pos": 590 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7A4-1", "uniprot_ac": "E1B7A4", "uniprot_id": "E1B7A4_BOVIN", "mass": { "chemical_mass": 29274.0, "monoisotopic_mass": 29274.0 }, "refseq": {}, "gene_names": [ { "name": "GLIPR1L2", "type": "recommended", "evidence": [ { "id": "E1B7A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7A4" } ] } ], "protein_names": [ { "name": "GLIPR1 like 2", "type": "synonym", "evidence": [ { "id": "E1B7A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7A4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7A4", "url": "https://www.uniprot.org/uniprotkb/E1B7A4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLIPR1L2", "url": "https://www.uniprot.org/uniprotkb/E1B7A4", "locus": { "chromosome": "5", "start_pos": 4926804, "end_pos": 4889686, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019260", "url": "https://www.ensembl.org/id/ENSBTAG00000019260" } ] } } ], "crossref": [ { "id": "E1B7A4", "url": "https://alphafold.ebi.ac.uk/entry/E1B7A4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019260", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019260", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TKC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7A4", "url": "https://www.uniprot.org/uniprotkb/E1B7A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7A4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7A4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEALPFSVEWYARWFPLTQTGIWKMCLCEFWLLLLGSGLKGHLLPDEEDVTFINEYVNLHNELRGNVLPRGANLRFMTWDVALSRTARAWGKKCVFERNTHLEELYMAHPKFNGIGENIWVGPENEFTASIAIRSWFEQRRKYNFEKNSCSGNCSNYLQLVWDRSYKVGCAVTPCSRIGRIKHAALFICNYAPGRGLSRRPYQRGLMCSQCDGYDRCTDFLCSKLKKINMKKIHNALNDKKMKWNTSLSLSC", "length": 252, "header": "tr|E1B7A4-1|E1B7A4_BOVIN Isoform 1 of GLIPR1 like 2 OS=Bos taurus OX=9913 GN=GLIPR1L2 PE=4 SV=4 CANONICAL=E1B7A4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TKC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC1/entry", "sequence": { "sequence": "MEALPFSVEWYARWFPLTQTGIWKMCLCEFWLLLLGSGLKGHLLPDEEDVTFINEYVNLHNELRGNVLPRGANLRFMTWDVALSRTARAWGKKCVFERNTHLEELYMAHPKFNGIGENIWVGPENEFTASIAIRSWFEQRRKYNFEKNSCSGNCSNYLQKRSVKKALS", "length": 168, "header": "tr|A0AAA9TKC1-1|E1B7A4_BOVIN Computationally mapped isoform of GLIPR1 like 2 OS=Bos taurus OX=9913 GN=GLIPR1L2 PE=4 SV=1 CANONICAL=E1B7A4-1" }, "locus": { "chromosome": "5", "start_pos": 4926646, "end_pos": 4889686, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131945.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131945.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097364.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097364.1" } ] } }, { "isoform_ac": "E1B7A4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7A4/entry", "sequence": { "sequence": "MEALPFSVEWYARWFPLTQTGIWKMCLCEFWLLLLGSGLKGHLLPDEEDVTFINEYVNLHNELRGNVLPRGANLRFMTWDVALSRTARAWGKKCVFERNTHLEELYMAHPKFNGIGENIWVGPENEFTASIAIRSWFEQRRKYNFEKNSCSGNCSNYLQLVWDRSYKVGCAVTPCSRIGRIKHAALFICNYAPGRGLSRRPYQRGLMCSQCDGYDRCTDFLCSKLKKINMKKIHNALNDKKMKWNTSLSLSC", "length": 252, "header": "tr|E1B7A4-1|E1B7A4_BOVIN Isoform 1 of GLIPR1 like 2 OS=Bos taurus OX=9913 GN=GLIPR1L2 PE=4 SV=4 CANONICAL=E1B7A4-1" }, "locus": { "chromosome": "5", "start_pos": 4926801, "end_pos": 4889686, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025642.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025642.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025642.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025642.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 173, "start_aa": "Thr", "end_pos": 173, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr173", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B7A4", "url": "https://www.uniprot.org/uniprotkb/E1B7A4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7A4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 252, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7A4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7A4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7A4" }, { "id": "SM00198", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00198" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCP", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 198, "start_aa": "Thr", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 173 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9Y2-1", "uniprot_ac": "E1B9Y2", "uniprot_id": "E1B9Y2_BOVIN", "mass": { "chemical_mass": 105988.0, "monoisotopic_mass": 105988.0 }, "refseq": { "ac": "XP_005213583", "name": "apical junction component 1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213583" }, "gene_names": [ { "name": "AJM1", "type": "recommended", "evidence": [ { "id": "E1B9Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" } ] }, { "name": "AJM1", "type": "synonym", "evidence": [ { "id": "XP_005213583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213583" } ] } ], "protein_names": [ { "name": "Apical junction component 1 homolog", "type": "synonym", "evidence": [ { "id": "E1B9Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2/entry#names_and_taxonomy" } ] }, { "name": "apical junction component 1 homolog", "type": "synonym", "evidence": [ { "id": "XP_005213583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213583" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Y2", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AJM1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2", "locus": { "chromosome": "11", "start_pos": 105935875, "end_pos": 105929232, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039708", "url": "https://www.ensembl.org/id/ENSBTAG00000039708" } ] } } ], "crossref": [ { "id": "ENSBTAG00000039708", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039708", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521846", "url": "https://www.ncbi.nlm.nih.gov/gene/521846", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521846", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521846", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEKTHDN", "url": "https://omabrowser.org/oma/group/KEKTHDN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9Y2", "url": "https://www.orthodb.org/?gene=E1B9Y2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21517:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21517:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF26649", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26649", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27982", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27982", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213583", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213583", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TKG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Y2", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Y2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRTDPPDLLVSTVYQDIKVAAPGPVSRPPPCERPMARPAAPAPFNKRHCRSFDFLEGLDGVAMEARPEAPPPEPAAPRARSRDGETRRRARSKSAPRAPPNLAPAPASPPVLPRRGREAQRTARADASPRREPAYPALRALANELHPIKLQPQRGGPGRIAPLCAAANRCAPAEPPAGPAPHVRCRLDIKPDEAVLQHAARGSRPCGPPEPAPWPRAAPQLHGLTVPGPRHVALSRTPTPSDSYCTDPRALYCDGPLPGPRDYAERRSVPFTTPPGPTQFFYTEEPEGHPGGFMASPGPPFDGYYPRPFLPEEPPGPSPRRGSGYYAGEARTFPVQEPPSRSYYGEAPRAYGPPCGPRYAPEEPRARPAARAFYTEDFGRYRNREALTRTYPHPRGSPAWGDWGPRPYRTLQVAPPPDPGPLLASWHGGTGTSPPRLATDSRHYSRSWDNILASGPRREDPLGRGRSYENLLGHEAREPRGTSPEGRRPPVVVNLSTSPRRYAALSLSETSLSEKGRVGEGPGRNWYVTPEITITDNDLRAAERPAARSWEMPGSRPRQSQPAAPDGPASGRQRSLEQLDELITDLVIDSRSPAGQALEPTSDGLGRQLRRLLDSRPSGPGGPALAPRSPPASAGSAEEPAGQGQAADASPEPSADEDDLMTCSNARCGRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSGPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPGATPPGAPARPVPAPRSPGPTVRKFAKVALAAGSPARPPPARGREPDMETLILTPPPGTAGLDQDGEAGRRAREVAFIHIQRELRLRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVASANLLDDIM", "length": 975, "header": "tr|E1B9Y2-1|E1B9Y2_BOVIN Isoform 1 of Apical junction component 1 homolog OS=Bos taurus OX=9913 GN=AJM1 PE=4 SV=2 CANONICAL=E1B9Y2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TKG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKG5/entry", "sequence": { "sequence": "MTRTDPPDLLVSTVYQDIKVAAPGPVSRPPPCERPMARPAAPAPFNKRHCRSFDFLEGLDGVAMEARPEAPPPEPAAPRARSRDGETRRRARSKSAPRAPPNLAPAPASPPVLPRRGREAQRTARADASPRREPAYPALRALANELHPIKLQPQRGGPGRIAPLCAAANRCAPAEPPAGPAPHVRCRLDIKPDEAVLQHAARGSRPCGPPEPAPWPRAAPQLHGLTVPGPRHVALSRTPTPSDSYCTDPRALYCDGPLPGPRDYAERRSVPFTTPPGPTQFFYTEEPEGHPGGFMASPGPPFDGYYPRPFLPEEPPGPSPRRGSGYYAGEARTFPVQEPPSRSYYGEAPRAYGPPCGPRYAPEEPRARPAARAFYTEDFGRYRNREALTRTYPHPRGSPAWGDWGPRPYRTLQVAPPPDPGPLLASWHGGTGTSPPRLATDSRHYSRSWDNILASGPRREDPLGRGRSYENLLGHEAREPRGTSPEGRRPPVVVNLSTSPRRYAALSLSETSLSEKGRVGEGPGRNWYVTPEITITDNDLRAAERPAARSWEMPGSRPRQSQPAAPDGPASGRQRSLEQLDELITDLVIDSRSPAGQALEPTSDGLGRQLRRLLDSRPSGPGGPALAPRSPPASAGSAEEPAGQGQAADASPEPSADEDDLMTCSNARCGRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSGPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPGATPPGAPARPVPAPRSPGPTVRKFAKVALAAGSPARPPPARGREPDMETLILTPPPGTAGLDQDGEAGRRAREVAFIHIQRELRLRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMACARAALTSQAGAGAETG", "length": 972, "header": "tr|A0AAA9TKG5-1|E1B9Y2_BOVIN Computationally mapped isoform of Apical junction component 1 homolog OS=Bos taurus OX=9913 GN=AJM1 PE=4 SV=1 CANONICAL=E1B9Y2-1" }, "locus": { "chromosome": "11", "start_pos": 105935199, "end_pos": 105931316, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090219.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090219.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098938.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098938.1" } ] } }, { "isoform_ac": "E1B9Y2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2/entry", "sequence": { "sequence": "MTRTDPPDLLVSTVYQDIKVAAPGPVSRPPPCERPMARPAAPAPFNKRHCRSFDFLEGLDGVAMEARPEAPPPEPAAPRARSRDGETRRRARSKSAPRAPPNLAPAPASPPVLPRRGREAQRTARADASPRREPAYPALRALANELHPIKLQPQRGGPGRIAPLCAAANRCAPAEPPAGPAPHVRCRLDIKPDEAVLQHAARGSRPCGPPEPAPWPRAAPQLHGLTVPGPRHVALSRTPTPSDSYCTDPRALYCDGPLPGPRDYAERRSVPFTTPPGPTQFFYTEEPEGHPGGFMASPGPPFDGYYPRPFLPEEPPGPSPRRGSGYYAGEARTFPVQEPPSRSYYGEAPRAYGPPCGPRYAPEEPRARPAARAFYTEDFGRYRNREALTRTYPHPRGSPAWGDWGPRPYRTLQVAPPPDPGPLLASWHGGTGTSPPRLATDSRHYSRSWDNILASGPRREDPLGRGRSYENLLGHEAREPRGTSPEGRRPPVVVNLSTSPRRYAALSLSETSLSEKGRVGEGPGRNWYVTPEITITDNDLRAAERPAARSWEMPGSRPRQSQPAAPDGPASGRQRSLEQLDELITDLVIDSRSPAGQALEPTSDGLGRQLRRLLDSRPSGPGGPALAPRSPPASAGSAEEPAGQGQAADASPEPSADEDDLMTCSNARCGRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSGPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPGATPPGAPARPVPAPRSPGPTVRKFAKVALAAGSPARPPPARGREPDMETLILTPPPGTAGLDQDGEAGRRAREVAFIHIQRELRLRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVASANLLDDIM", "length": 975, "header": "tr|E1B9Y2-1|E1B9Y2_BOVIN Isoform 1 of Apical junction component 1 homolog OS=Bos taurus OX=9913 GN=AJM1 PE=4 SV=2 CANONICAL=E1B9Y2-1" }, "locus": { "chromosome": "11", "start_pos": 105934240, "end_pos": 105931316, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090581.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090581.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079489.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079489.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 240, "start_aa": "Thr", "end_pos": 240, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr240", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 279, "start_aa": "Thr", "end_pos": 279, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr279", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 824, "start_aa": "Thr", "end_pos": 824, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr824", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 842, "start_aa": "Thr", "end_pos": 842, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr842", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521846", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521846", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AIR1-1", "protein_name": "Apical junction component 1 homolog", "gene_name": "AJM1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTRTDPPDILVSTVYQDIKVASAAPGDSIVCQPLARCDASMSSSLPRDPQPFNKRHCRSFDFLESLDEPLGAPPAMERPCPRPGTPEPTPGPPGRRAPPKPDPYGGRAPPPAREAPRGEPKRRARSKSAPRMKPSFTPVPIAVSASPPPARRGREALRVERGPPRAEPSPRRESHVPLRALANEVHPIKLQPQRSSVSRISPLCVGSNCFEEGPGAKVGASPHVKCRVDIKPDEAVLVHTARSLRAAQSRPELPQWPRAPRAARSLAVPGSRQVSVSRTPTPSDSYSGDPPLLPYPGEYFEADPRVLAYQTVPVPASREFREYPERGCMTFSAAGVPTKFFYAEEPVRCPSPAMPLRSSGYASYPYPVRQGPPQHFYVEDPAKAGVHTVPPRTLYVEEARGYPVQEAPSHAFYREEPRFYTPRSTPVKALYTEDARTYPALGSSARVFYAEDYGKYREREVLSRTCPPPRSTQPLHFGDWYCPERSALPYQSLQVSRFSPQPAGREAMLSSWHASYSTNPPRLGRDSQHYSKSWDNILAPAARREEALQRGRSYENLLVQEQHRALSPDERRQPVVINLSSSPKRYAALSLSESSILERVHSDSGRGPLGRSWYVTPEITITDNDIRANGTGRSERRSASWDVLDAGREQTPYAAPYAPQPVPKESGSARQRSLEQLDELITDLVIDYKPAPGHRAGDRDSLAEQLKKLLSSSAPGPPRRGEGRKVPPSVPESFRPTKEQPGPSSFGSAPRPQPSPPASGTFEKPLENCSPDLSAEEDDMMMCSNAKCRRTETMFNACLYFKSCHSCYTYYCSRHCRREDWDTHKESCVYGRVGSVCRHVLQFCRENAEVHKAFSRIAKVGYLSRGRGVLFLGFPNSGSAENFLQFGLESLLMSPTYLSLRELESYSDNLGEYARELRETGNQYDPDECFLLNVTVAVAQKVPERPSPKVQVPTVRKYAKVALASSSPEKKIPKKERDMETLILTPPPGTADIDKEGEEGRKAREVCFINIQRELRIRGVFLRHEFPAVYEQLCDFVESNKRFTPTTIYPIDKRTGKQFMCMIMAASEPRTLDWVASPNLLDDIM", "length": 1085 }, "evidence": [ { "id": "E1B9Y2", "url": "https://omabrowser.org/oma/group/E1B9Y2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2AJA9-1", "protein_name": "Apical junction component 1 homolog", "gene_name": "Ajm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRTDPPDLLVSTVYQDIKVVDPGLTSKRQPCERSVARPAAPTPFNKRHCRSFDFLEALDEPTMETHPEPPPPEPAPPRARPRDSEPRRRTRSKSAPRASQGLATAPASPPVLQRRGREAQRAVRVEGSPRREPSYPALRALANELHPIKLQPQRGGPGRIAPLCATPGRCAPPEPPSGPVPHVRCRLDIKPDEAVLQHAARSSRSCAPRETTSWARTAPQFHGLTVPGPRHVALSRTPTPSDLYCTDPRTLYCDGPLPGPRDYLEHRSQPFTTPPGPTQFFYTEEPEGYAGSFTTSPGLPFDGYCSRPYLSEEPPRPSPRRGGSYYAGEVRTFPIQEPPSRSYYGETTRAYGMPFVPRYVPEEPRAHPGARTFYTEDFGRYRERDVLARTYPHPRSSPPWADWGPRPYRTLQVMPPPAPGPLLASWHGGTGTSPPRLATDSRHYSRSWDNILAPGPRREDPLGRGRSYENLLGREVRDTRGSSPEGRRPPVVVNLSTSPRRYAALSLSETSLTEKGRAGESLGRNWYVTPEITITDNDLRSVDRPTAKGWELPGGRPRQPVSTVPEGPASSRQRSLEQLDELITDLVIDSRSPAQAPEPAAEGLGRQLRRLLDSRAAGPGGATLLAPSRSPPASAGSTEEPTGSGEAADASPEPSADEDDLMTCSNARCRRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSSPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPSAAPPGAAARPAPRTPGPTVRKFAKVALAAGSPTRPPPARGGEPDMETLILTPPPGTAGLDEEGEAGRRAREVAFIHIQRELRMRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVASANLLDDIM", "length": 974 }, "evidence": [ { "id": "E1B9Y2", "url": "https://omabrowser.org/oma/group/E1B9Y2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C9J069-1", "protein_name": "Apical junction component 1 homolog", "gene_name": "AJM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRTDPPDLLVSTVYQDIKVATPGPASKCSPCERSVARPAEPAPFNKRHCRSFDFLEALDGPAMETLPEPPPPESAVPRARTREAEPRRRARSKSAPRAPPGLTPAPASPPVLPRRGREAQRAARAEASPRREPAYPALRALANELHPIKLQPQRGGPGRVAPLCAAAGRCAPPEPPAGPAPHVRCRLDIKPDDAVLQHATRGSRSCGPTEAAHWARPAPQFHGLTVPGPRHMALSRTPTPSDSYCADPRAFYCDGPLPGPRDYAERRSLPFTTPPGPTQFFYTEEPQGFRGSFAASPGPTFDAYYPRPYPSEELSGPSPRRMGGYYAGEVRTFPIQEPPSRSYYGEAPRAYGLPYGPRYVPEEPRAHSTARPFYTEDFGRYRERDVLARTYPHPRSSPAWADWGPRPYRTLQVVPPSDPDPLLASWHGGTGTSPPRLATDSRHYSRSWDNILAPGPRREDPLGRGRSYENLLGREVREPRGVSPEGRRPPVVVNLSTSPRRYAALSLSETSLTEKGRAGEGLGRNWYVTPEITITDNDLRATERPSARAWELPGGRTRPPPHAAPDGPTSGRQRSLEQLDELITDLVIDSRPTAGQASEPAADCLGPQLRRLLDSRPAGSGAPALAPPRSPPASAGSAEEPAAPGEAADASPEPSADEDDLMTCSNARCRRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSGPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPGTAPPGTPALPAPAPRSHGPTVRKFAKVALAAGSPARPPPARSREPDMETLILTPPPGTAGLDQDGEAGRRAREVAFIHIQRELRLRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVASANLLDDIM", "length": 976 }, "evidence": [ { "id": "E1B9Y2", "url": "https://omabrowser.org/oma/group/E1B9Y2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZTF0-1", "protein_name": "Apical junction component 1 homolog", "gene_name": "Ajm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTRTDPPDLLVSTVYQDIKVVDPGLTSKRQPCERSVARPAASTPFNKRHCRSFDFLEALDEPTMETHPEPPPPEPAPPRARPRDGEPRRRTRSKSAPRVPQSLTTAPASPPVLQRRGREAQRAVRVEGSPCREPSYPALRALANELHPIKLQPQRGGPGRIAPLCATPGRCAPPESSAGPVPHVRCRLDIKPDEAVLQHAARSSRSGAPRETSSWARTVPQFHGLTVPGPRHVALSRTPTPSDLYCTDPRPLYCDGPLPGPRDYLEHRTQPFTTPPGPTQFFYTEEPEGYAGSFTASPGLPFDGYCSRPYLSEEPPRPSPRRGGSYYAGEVRTFPIQEPPSRSYYGETTRAYGLPFVPRYVPEEPRVHPGARAFYTEDFGRYRERDALARTYPHPRSSPTWADWGPRPYRTLQVMPPPAPGPLLASWHGGTGTSPPRLVTDSRHYSRSWDNILAPGPRREDPLGRGRSYENLLGREVRDTRGSSPEGRRPPVVVNLSTSPRRYAALSLSETSLTEKGRTGECLGRNWYVTPEITITDNDLRSAERPTAKGWELPGGRPRQPVPVVPEGPASSRQRSLEQLDELITDLVIDSRSPAQAPEPTAEGLGRQLRRLLDSRPAGPGGATALAPSRSPPASAGSTEEPTGSGEAAEASPEPSADEDDLMTCSNARCRRTETMFNACLYFKSCHSCYTYYCSRLCRREDWDAHKARCVYGRVGSVCRHVLQFCRDSSPVHRAFSRIARVGFLSRGRGVLFLGFPSPGSADNFLRFGLEGLLLSPTYLSLRELATHAAPLGSYARELAAAGRLYEPAECFLLSVSVAVGPGAAPPGAAARPAPRSPGPTVRKFAKVALAAGSPTRPPPARGGEPDMETLILTPPPGTAGLDEEGEAGRRAREVAFIHIQRELRLRGVFLRHEFPRVYEQLCEFVEANRRFTPTTIYPTDRRTGRPFMCMIMAASEPRALDWVASANLLDDIM", "length": 974 }, "evidence": [ { "id": "E1B9Y2", "url": "https://omabrowser.org/oma/group/E1B9Y2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B9Y2", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell junction organization", "id": "GO:0045216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045216", "evidence": [ { "database": "UniProtKB", "id": "E1B9Y2", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9Y2", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "E1B9Y2", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y2" }, { "id": "PS50865", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MYND-type", "eco_id": "ECO_0000259", "start_pos": 666, "end_pos": 709, "start_aa": "Asn", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 240, 279, 824, 842 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 495, "end_pos": 497 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBK9-1", "uniprot_ac": "E1BBK9", "uniprot_id": "E1BBK9_BOVIN", "mass": { "chemical_mass": 65964.0, "monoisotopic_mass": 65964.0 }, "refseq": {}, "gene_names": [ { "name": "SYTL1", "type": "recommended", "evidence": [ { "id": "E1BBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ] } ], "protein_names": [ { "name": "Synaptotagmin-like protein 1", "type": "recommended", "evidence": [ { "id": "E1BBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK9/entry#names_and_taxonomy" } ] }, { "name": "Exophilin-7", "type": "synonym", "evidence": [ { "id": "E1BBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYTL1", "url": "https://www.uniprot.org/uniprotkb/E1BBK9", "locus": { "chromosome": "2", "start_pos": 125932523, "end_pos": 125943055, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010253", "url": "https://www.ensembl.org/id/ENSBTAG00000010253" } ] } } ], "crossref": [ { "id": "E1BBK9", "url": "https://alphafold.ebi.ac.uk/entry/E1BBK9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010253", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010253", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04020", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04020", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08393", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08393", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527641", "url": "https://www.ncbi.nlm.nih.gov/gene/527641", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527641", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527641", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M443", "url": "https://www.orthodb.org/?gene=A0A3Q1M443", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBK9", "url": "https://www.orthodb.org/?gene=E1BBK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M443", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M443", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M443-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M443-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY21", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY21-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBK9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQRGHPAPEGPWSLPGLLMAREPEPEADGLLDLSFLTEEEQEAIAEVLKRDAHLRQLEEGRISKLRASLADPGQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKGCRSERSSPEGAGLVQPSSLGDQAGGSDVEAEAAGKETEEALEPRLSVDEGPQERFIEAEGPDVPSPRVSTKPSEQEEEPQAEEDEREAPDLEHPLVVAGEEADPEMQPPSMGEEEPQTPPAQAASEMLENGEENPGPDSSFDRMLSSSSSMSSLNSSTLSGSQMSLSGEPEAGAVQVRGSVHFALRYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTTVKKRNLNPVFNEILRYSVPQTELRGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWDSEPTWLPLQPRVPPSPDDLPSRGLLSLSLKYLPAGSEGPGLPPSGELHFWVKEVQDLIPLRSGSPDTFVQCSVLPDDSRASRQRTRVVRRSLNPMFNHTMVYDGFGPTDLRQACAELSLWDHGALGSRQLGGTRLSLGTGSSYGLQVPWMDSTREERQLWQTLLERPSRTSRSLLEGRSPQNGGGVAVKLVQRLWASPR", "length": 598, "header": "tr|E1BBK9-1|E1BBK9_BOVIN Isoform 1 of Synaptotagmin-like protein 1 OS=Bos taurus OX=9913 GN=SYTL1 PE=4 SV=4 CANONICAL=E1BBK9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M443-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M443/entry", "sequence": { "sequence": "MPQRGHPAPEGPWSLPGLLMAREPEPEADGLLDLSFLTEEEQEAIAEVLKRDAHLRQLEEGRISKLRASLADPGQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKGCRSERSSPEGAGLVQPSSLGDQAGGSDVEAEAAGKETEEALEPRLSVDEGPQERFIEAEGPDVPSPRVSTKPSEQEEEPQAEEDEREAPDLEHPLVVAGEEADPEMQPPSMGEEEPQTPPAQTQAASEMLENGEENPGPDSSFDRMLSSSSSMSSLNSSTLSGSQMSLSGEPEAGAVQVRGSVHFALRYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTTVKKRNLNPVFNEILRYSVPQTELRGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWDSEPTWLPLQPRVPPSPDDLPSRGLLSLSLKYLPAGSEGPGLPPSGELHFWVKEVQDLIPLRSGSPDTFVQCSVLPDDSRASRQRTRVVRRSLNPMFNHTMVYDGFGPTDLRQACAELSLWDHGALGSRQLGGTRLSLGTGEWGRAPRGPDAKRPGLSMWPRAGLCPFLSLVSTENWGGDGA", "length": 582, "header": "tr|A0A3Q1M443-1|A0A3Q1M443_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 1 OS=Bos taurus OX=9913 GN=SYTL1 PE=4 SV=2 CANONICAL=E1BBK9-1" }, "locus": { "chromosome": "2", "start_pos": 125940808, "end_pos": 125934521, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077895.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077895.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062994.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062994.2" } ] } }, { "isoform_ac": "A0AAA9TMG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMG4/entry", "sequence": { "sequence": "MPQRGHPAPEGPWSLPGLLMAREPEPEADGLLDLSFLTEEEQEAIAEVLKRDAHLRQLEEGRISKLRASLADPGQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKGCRSERSSPEGAGLVQPSSLGDQAGGSDVEAEAAGKETEEALEPRLSVDEGPQERFIEAEGPDVPSPRVSTKPSEQEEEPQAEEDEREAPDLEHPLVVAGEEADPEMQPPSMGEEEPQTPPAQTQAASEMLENGEENPGPDSSFDRMLSSSSSMSSLNSSTLSGSQMSLSGEPEAGAVQVRGSVHFALRYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTTVKKRNLNPVFNEILRYSVPQTELRGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWDSEPTWLPLQPRVPPSPDDLPSRGLLSLSLKYLPAGSEGPGLPPSGELHFWVKEVQDLIPLRSGSPDTFVQCSVLPDDSRASRQRTRVVRRSLNPMFNHTMVYDGFGPTDLRQACAELSLWDHGALGSRQLGGTRLSLGTGSSYGLQVPWMDSTREERQLWQTLLERPCEWVDGLLPLRTNLAPRT", "length": 586, "header": "tr|A0AAA9TMG4-1|E1BBK9_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 1 OS=Bos taurus OX=9913 GN=SYTL1 PE=4 SV=1 CANONICAL=E1BBK9-1" }, "locus": { "chromosome": "2", "start_pos": 125940808, "end_pos": 125934300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117325.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117325.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098420.1" } ] } }, { "isoform_ac": "A0ABI0NY21-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY21/entry", "sequence": { "sequence": "MPQRGHPAPEGPWSLPGLLMAREPEPEADGLLDLSFLTEEEQEAIAEVLKRDAHLRQLEEGRISKLRASLADPGQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKGCRSERSSPEGAGLVQPSSLGDQAGGSDVEAEAAGKETEEALEPRLSVDEGPQERFIEAEGPDVPSPRVSTKPSEQEEEPQAEEDEREAPDLEHPLVVAGEEADPEMQPPSMGEEEPQTPPAQAASEMLENGEENPGPDSSFDRMLSSSSSMSSLNSSTLSGSQMSLSGEPEAGAVQVRGSVHFALRYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTTVKKRNLNPVFNEILRYSVPQTELRGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWDSEPTWLPLQPRVPPSPDDLPSRGLLSLSLKYLPAGSEAQCCLMTAGPAASGQGWCDAASTPCSITPWSMMASGLLTCARPVRSSPSGTMGPWAAASWGAHASAWAPAAATGSRCPGWTPHVRRGSCGKPSWSGHVSGWMAFCPSEPTWPPGHSCLTCSTKPFFWDPHF", "length": 567, "header": "tr|A0ABI0NY21-1|A0ABI0NY21_BOVIN Computationally mapped isoform of Synaptotagmin like 1 OS=Bos taurus OX=9913 GN=SYTL1 PE=4 SV=1 CANONICAL=E1BBK9-1" }, "locus": { "chromosome": "2", "start_pos": 125940808, "end_pos": 125934251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147347.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147347.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106959.1" } ] } }, { "isoform_ac": "E1BBK9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBK9/entry", "sequence": { "sequence": "MPQRGHPAPEGPWSLPGLLMAREPEPEADGLLDLSFLTEEEQEAIAEVLKRDAHLRQLEEGRISKLRASLADPGQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKGCRSERSSPEGAGLVQPSSLGDQAGGSDVEAEAAGKETEEALEPRLSVDEGPQERFIEAEGPDVPSPRVSTKPSEQEEEPQAEEDEREAPDLEHPLVVAGEEADPEMQPPSMGEEEPQTPPAQAASEMLENGEENPGPDSSFDRMLSSSSSMSSLNSSTLSGSQMSLSGEPEAGAVQVRGSVHFALRYEPGAAELRVHVIQCQGLAAARRRRSDPYVKSYLLPDKQSKRKTTVKKRNLNPVFNEILRYSVPQTELRGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWDSEPTWLPLQPRVPPSPDDLPSRGLLSLSLKYLPAGSEGPGLPPSGELHFWVKEVQDLIPLRSGSPDTFVQCSVLPDDSRASRQRTRVVRRSLNPMFNHTMVYDGFGPTDLRQACAELSLWDHGALGSRQLGGTRLSLGTGSSYGLQVPWMDSTREERQLWQTLLERPSRTSRSLLEGRSPQNGGGVAVKLVQRLWASPR", "length": 598, "header": "tr|E1BBK9-1|E1BBK9_BOVIN Isoform 1 of Synaptotagmin-like protein 1 OS=Bos taurus OX=9913 GN=SYTL1 PE=4 SV=4 CANONICAL=E1BBK9-1" }, "locus": { "chromosome": "2", "start_pos": 125940808, "end_pos": 125932523, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013544.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013544.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013544.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013544.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527641", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527641", "resource": "KEGG Pathway" }, { "id": "R-BTA-8854214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "resource": "Reactome", "description": "TBC/RABGAPs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" }, { "name": "exocytic vesicle", "id": "GO:0070382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070382", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" }, { "name": "neurexin family protein binding", "id": "GO:0042043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042043", "evidence": [ { "database": "UniProtKB", "id": "E1BBK9", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBK9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 598, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBK9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBK9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 288, "end_pos": 407, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK9" }, { "id": "PS50916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RabBD", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 87, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 }, { "start_pos": 496, "end_pos": 498 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9U9-1", "uniprot_ac": "E1B9U9", "uniprot_id": "E1B9U9_BOVIN", "mass": { "chemical_mass": 16397.0, "monoisotopic_mass": 16397.0 }, "refseq": {}, "gene_names": [ { "name": "PTH2", "type": "recommended", "evidence": [ { "id": "E1B9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U9" } ] } ], "protein_names": [ { "name": "Tuberoinfundibular peptide of 39 residues", "type": "recommended", "evidence": [ { "id": "E1B9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U9/entry#names_and_taxonomy" } ] }, { "name": "Parathyroid hormone 2", "type": "synonym", "evidence": [ { "id": "E1B9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9U9", "url": "https://www.uniprot.org/uniprotkb/E1B9U9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTH2", "url": "https://www.uniprot.org/uniprotkb/E1B9U9", "locus": { "chromosome": "18", "start_pos": 55882631, "end_pos": 55888458, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001062", "url": "https://www.ensembl.org/id/ENSBTAG00000001062" } ] } } ], "crossref": [ { "id": "E1B9U9", "url": "https://alphafold.ebi.ac.uk/entry/E1B9U9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001062", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001062", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28585", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28585", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28585:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28585:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14980", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14980", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TPA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U9", "url": "https://www.uniprot.org/uniprotkb/E1B9U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRARRGKGAGLVGTCSSPAWGNSALRWGRNFTGVCEISRELGVRASADLGWGPVLLGDGDPPGTQEPPGAAAAAAPASCVLGPPHGLRSRPTSCGVFRLRTPGEARAGPATPQSRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP", "length": 156, "header": "tr|E1B9U9-1|E1B9U9_BOVIN Isoform 1 of Tuberoinfundibular peptide of 39 residues OS=Bos taurus OX=9913 GN=PTH2 PE=3 SV=3 CANONICAL=E1B9U9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TPA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA3/entry", "sequence": { "sequence": "MEAGIPRSHAGLGQRYLGDGDPPGTQEPPGAAAAAAPASCVLGPPHGLRSRPTSCGVFRLRTPGEARAGPATPQSRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP", "length": 116, "header": "tr|A0AAA9TPA3-1|E1B9U9_BOVIN Computationally mapped isoform of Tuberoinfundibular peptide of 39 residues OS=Bos taurus OX=9913 GN=PTH2 PE=3 SV=1 CANONICAL=E1B9U9-1" }, "locus": { "chromosome": "18", "start_pos": 55885140, "end_pos": 55882673, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122946.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122946.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100378.1" } ] } }, { "isoform_ac": "E1B9U9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U9/entry", "sequence": { "sequence": "MPRARRGKGAGLVGTCSSPAWGNSALRWGRNFTGVCEISRELGVRASADLGWGPVLLGDGDPPGTQEPPGAAAAAAPASCVLGPPHGLRSRPTSCGVFRLRTPGEARAGPATPQSRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP", "length": 156, "header": "tr|E1B9U9-1|E1B9U9_BOVIN Isoform 1 of Tuberoinfundibular peptide of 39 residues OS=Bos taurus OX=9913 GN=PTH2 PE=3 SV=3 CANONICAL=E1B9U9-1" }, "locus": { "chromosome": "18", "start_pos": 55888444, "end_pos": 55882673, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001408.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001408.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001408.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001408.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-373080", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "resource": "Reactome", "description": "Class B/2 (Secretin family receptors)" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1B9U9", "url": "https://www.uniprot.org/uniprotkb/E1B9U9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "E1B9U9", "url": "https://www.uniprot.org/uniprotkb/E1B9U9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9U9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 156, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9U9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9U9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A7MBF6-1", "uniprot_ac": "A7MBF6", "uniprot_id": "ARMD1_BOVIN", "mass": { "chemical_mass": 49442.0, "monoisotopic_mass": 49442.0 }, "refseq": { "ac": "NP_001095754", "name": "armadillo-like helical domain containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095754" }, "gene_names": [ { "name": "ARMH1", "type": "recommended", "evidence": [ { "id": "A7MBF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBF6" } ] }, { "name": "ARMH1", "type": "synonym", "evidence": [ { "id": "NP_001095754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095754" } ] }, { "name": "C3H1orf228", "type": "synonym", "evidence": [ { "id": "NP_001095754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095754" } ] } ], "protein_names": [ { "name": "Armadillo-like helical domain containing protein 1", "type": "recommended", "evidence": [ { "id": "A7MBF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBF6/entry#names_and_taxonomy" } ] }, { "name": "armadillo-like helical domain containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001095754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095754" } ] }, { "name": "uncharacterized protein C1orf228 homolog", "type": "synonym", "evidence": [ { "id": "NP_001095754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095754" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MBF6", "url": "https://www.uniprot.org/uniprotkb/A7MBF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARMH1", "url": "https://www.uniprot.org/uniprotkb/A7MBF6", "locus": { "chromosome": "3", "start_pos": 101291619, "end_pos": 101354746, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011822", "url": "https://www.ensembl.org/id/ENSBTAG00000011822" } ] } } ], "crossref": [ { "id": "A7MBF6", "url": "https://alphafold.ebi.ac.uk/entry/A7MBF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011822", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011822", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614845", "url": "https://www.ncbi.nlm.nih.gov/gene/614845", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614845", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614845", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETICECY", "url": "https://omabrowser.org/oma/group/ETICECY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MBF6", "url": "https://www.orthodb.org/?gene=A7MBF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34258:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34258:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17741", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17741", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095754", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TU33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MBF6", "url": "https://www.uniprot.org/uniprotkb/A7MBF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MBF6-1", "url": "https://www.uniprot.org/uniprotkb/A7MBF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSIKEQAAISRLLSFLQDWDNAGKVARSNILNNFIEANQGKTAPELEQEFSQGASLFLVRLTTWLRLTYMTGSPLDKLLRSIGVFLSAVSSNRYLIEFLEVGGVLTLLEILALNKIKEEDKKESIKLLQVIANSGRKYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLIHGNPKYQNQVYKGLIALLPCASPKAQQLALQTLRTAQSIIGTTHPSIVDCVLKVLCTMHLEVQYEAIELIKDLVNYDVCPALLKGLVALLIPSFKETSKLQSQIVSDSSVLELTAHLPLFLQQAAAAKAIGVLARHNTTLAEEMLHLRVIHSLMAAMGNTDHSNSQRQASLTLEYFVQLFPVVEEHVRKTMGEELYKLFLSNAENLYMNIDSIQADILAANKVNVTRVLHLSGLSYSNMSFYFGHPNEDQVAYVTHFRKEDVEEKE", "length": 442, "header": "sp|A7MBF6-1|ARMD1_BOVIN Isoform 1 of Armadillo-like helical domain containing protein 1 OS=Bos taurus OX=9913 GN=ARMH1 PE=2 SV=1 CANONICAL=A7MBF6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TU33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU33/entry", "sequence": { "sequence": "MTSIKEQAAISRLLSFLQDWDNAGKVARSNILNNFIEANQGKTAPELEQEFSQGASLFLVRLTTWLRLTYMTGSPLDKLLRSIGVFLSAVSSNRYLIEFLEVGGVLTLLEILALNKIKEEDKKESIKLLQVIANSGRKYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLIHGNPKYQNQVYKGLIALLPCASPKAQQLALQTLRTAQSIIGTTHPSIVDCVLKVLCTMHLEVQYEAIELIKDLVNYDVCPALLKGLVALLIPSFKETSKLQSQIVSDSSVLELTAHLPLFLQQAAAAKAIGVLARHNTTLAEEMLHLRVIHSLMAAMGNTDHSNSQRQASLTLEYFVQLFPVVEEHVRKTMGEELYKLFLSNAENLYMNIDSIQADILAANKVNVTRGEWGARGPGPERQRHPVSGSSPASSAAPQRPLLQQHELLLWAS", "length": 446, "header": "tr|A0AAA9TU33-1|ARMD1_BOVIN Computationally mapped isoform of Armadillo-like helical domain containing protein 1 OS=Bos taurus OX=9913 GN=ARMH1 PE=2 SV=1 CANONICAL=A7MBF6-1" }, "locus": { "chromosome": "3", "start_pos": 101338478, "end_pos": 101292623, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091668.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091668.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100899.1" } ] } }, { "isoform_ac": "A7MBF6-1", "url": "https://www.uniprot.org/uniprotkb/A7MBF6/entry#A7MBF6-1", "sequence": { "sequence": "MTSIKEQAAISRLLSFLQDWDNAGKVARSNILNNFIEANQGKTAPELEQEFSQGASLFLVRLTTWLRLTYMTGSPLDKLLRSIGVFLSAVSSNRYLIEFLEVGGVLTLLEILALNKIKEEDKKESIKLLQVIANSGRKYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLIHGNPKYQNQVYKGLIALLPCASPKAQQLALQTLRTAQSIIGTTHPSIVDCVLKVLCTMHLEVQYEAIELIKDLVNYDVCPALLKGLVALLIPSFKETSKLQSQIVSDSSVLELTAHLPLFLQQAAAAKAIGVLARHNTTLAEEMLHLRVIHSLMAAMGNTDHSNSQRQASLTLEYFVQLFPVVEEHVRKTMGEELYKLFLSNAENLYMNIDSIQADILAANKVNVTRVLHLSGLSYSNMSFYFGHPNEDQVAYVTHFRKEDVEEKE", "length": 442, "header": "sp|A7MBF6-1|ARMD1_BOVIN Isoform 1 of Armadillo-like helical domain containing protein 1 OS=Bos taurus OX=9913 GN=ARMH1 PE=2 SV=1 CANONICAL=A7MBF6-1" }, "locus": { "chromosome": "3", "start_pos": 101338478, "end_pos": 101292562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043041.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043041.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040637.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040637.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614845", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614845", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BS81-1", "protein_name": "Armadillo like helical domain containing 1", "gene_name": "ARMH1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTSIKEQAAISRLLSFLQDWDNAGRVARSHILHNFIDSNQGKTAPELEQEFSQGASLFLARLTTWLRLTYMTGSCLEKLLRSIGVFLSAVSSNRYLIEFLEVGGVLTLLEILALEKIKEEDKKESVKLLQVIANSGRKYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNPKYQNQVYKGLIALLPCASPKAQQLSLQTLRTAQSIVGTTHPSIVDGVLKVLRTMHLEVQYEAIELIKDLVNYDVCPALLKGLVALLIPSFKETSKLQPKIVDESSVLQLTGHLPLFLQQAAAAKAIGILARRNTSLAEEMLHLRVVHSLLAAMGNTDHSNSQRQASLTLEYFVQLFPVVEEHVRRSMGEELYRLFLSDAEDLYRKMDSIQADILAANKVNVTKALYLSGLSPAT", "length": 414 }, "evidence": [ { "id": "A7MBF6", "url": "https://omabrowser.org/oma/group/A7MBF6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M3J6-1", "protein_name": "Armadillo-like helical domain containing protein 1", "gene_name": "Armh1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSIKEQAAISRLLSFLQEWDNASRNLRSQILTKFIDSNEGKTGPELEQEFSQGASLFLIRLTTWLRITYMTGLDLEKILRSIGIFLSAVSSNRYLIEFLEIGGVLTLLEILGLEKIKEEDKRESVKLLQIIASTGRKYKELICESYGVRSIAEFLAKSQSEETQEEVQILLDTLLHGNPKYQNQVYKGLIALLPCGSPKAQQLALQTLRTAQSIIGATHPSIVDCVLTVLGTMHLEVQYEAIELIKDLIHYDVRLPLLKGLVALLIPSVKETSKLQANIFTESSILQVTTQLPVFLKQAAAAKTIGILARSDLKVAEELLYLRVIHSLMTAMGNTDHSNSQRLASLTLEFFVQMFPLVEEHVHKSMGEELYQLFLSNAEILYAKMDSIQADILAANKVNVSKALCLCEGTTNSCFSFFMGPGDVNEVEYVTHFEKHQPESKE", "length": 443 }, "evidence": [ { "id": "A7MBF6", "url": "https://omabrowser.org/oma/group/A7MBF6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A9P2-1", "protein_name": "Armadillo-like helical domain containing 1", "gene_name": "Armh1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSIKEQAAISRLLSFLQEWDNAGKSLRTQILTTFIETNQGKTGPELELEFSQGASLFLIRVTTWLRIIYMTGLDLEMILRSIGIFLSAVSSNRYLIEFLEIGGVLTLLEILGLEKIKEEDKKESIKLLQIIANTGRKYKELICESYGVRAIAEFLAKSKSEETQEEVQVLLDTLVHGNPKYQNQVYKGLIALLPCGSPKAQQLALQTLKTAQSIVGATHPSIVDCVLMVLSTVHLEVQYEAIELIKDLIHYDVRLPLLKGLIAMLIPPVKETSKLQARIFSDSSILQITTQLPVFLQQAAAAKTIGILARSDLNLAEEMLHLRVIHSLMSAMGNTDHSNSQRLASLTLEYFVQMFPLVEEHVRNSMGEELYQLFLSDAEILYTKIDSIQADILAANKVNVTRDSCDHINNSCISFSTSSDASNQVGGISDFEKLHSESRE", "length": 441 }, "evidence": [ { "id": "A7MBF6", "url": "https://omabrowser.org/oma/group/A7MBF6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q963-1", "protein_name": "Armadillo-like helical domain containing 1", "gene_name": "Armh1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSVKEQAAISRLLSFLQEWDNAGKGLRNQILTTFIKTNEGKTGPELELEFSQGASLFLIRVTTWLRIIYMTGLELEKILRSIGIFLSAVSSNRYLLEFLEIGGVLTLLEILGVEKINEEDKKESIKLLQIIANTGRKYKELICESYGVRAIAEFLAKSKSEETQEEVQVLLETLVHGNPKYQNQVYKGLIALLPCESPKAQRLALQTLKTAQSIVGATHPSIVDRVLTVLSTVHLEVQYEAIELIKDLIHYDVRLPLLKGLVALLMPPVKETSKLQAKIFSDSSILQTTTQLPVFLQQAAAAKTIGILARNDLNLAVELLNLRVVHGLMSAMGNTDHSNSQRLASLTLEYFVQMFPLVEEQVRKSMGDELYQLFLNDAEILYTKIDSIQADILAANKVNATTDSCECIDNSSISFSTGSNDMNQRGYTNDFEKLHSKSKE", "length": 441 }, "evidence": [ { "id": "A7MBF6", "url": "https://omabrowser.org/oma/group/A7MBF6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PIY5-1", "protein_name": "Armadillo-like helical domain containing protein 1", "gene_name": "ARMH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSIKEQAAISRLLSFLQEWDNAGKVARSHILDKFIETNQGKTAPELEQEFSQGASLFLVRLTTSLRITYMTDSCLEKLLRSIGIFLSAVSSNRYLIEFLEVGGVLTLLEILGLEKIKEEAKKESVKLLQVIANSGRTYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNPKYQNQVYKGLIALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQYEAIELIKDLVGYDVRQALLKGLVALLIPSVKEISKLQAKILSDPSVLQLTPSLPMFLQQAAAAKAIGVLARNDMSIAEELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLVAEHVRKCMGEELYQLFLSNAEDLYMKIDSIQADILAANTVNVTKALCLHGSSYSMNTLYGSRDSAQMAYLTHFEEDVESKE", "length": 440 }, "evidence": [ { "id": "A7MBF6", "url": "https://omabrowser.org/oma/group/A7MBF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A7MBF6", "url": "https://www.uniprot.org/uniprotkb/A7MBF6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A7MBF6", "url": "https://www.uniprot.org/uniprotkb/A7MBF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MBF6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 442, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MBF6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MBF6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 313, "end_pos": 315 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB75-1", "uniprot_ac": "E1BB75", "uniprot_id": "E1BB75_BOVIN", "mass": { "chemical_mass": 36944.0, "monoisotopic_mass": 36944.0 }, "refseq": { "ac": "NP_001179082", "name": "ELL-associated factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179082" }, "gene_names": [ { "name": "EAF1", "type": "recommended", "evidence": [ { "id": "E1BB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB75" } ] }, { "name": "EAF1", "type": "synonym", "evidence": [ { "id": "NP_001179082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179082" } ] } ], "protein_names": [ { "name": "ELL associated factor 1", "type": "synonym", "evidence": [ { "id": "E1BB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB75/entry#names_and_taxonomy" } ] }, { "name": "ELL-associated factor 1", "type": "synonym", "evidence": [ { "id": "NP_001179082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179082" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB75", "url": "https://www.uniprot.org/uniprotkb/E1BB75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EAF1", "url": "https://www.uniprot.org/uniprotkb/E1BB75", "locus": { "chromosome": "1", "start_pos": 152463273, "end_pos": 152450642, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019202", "url": "https://www.ensembl.org/id/ENSBTAG00000019202" } ] } } ], "crossref": [ { "id": "E1BB75", "url": "https://alphafold.ebi.ac.uk/entry/E1BB75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019202", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019202", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507577", "url": "https://www.ncbi.nlm.nih.gov/gene/507577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FRAPMKP", "url": "https://omabrowser.org/oma/group/FRAPMKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BB75", "url": "https://www.orthodb.org/?gene=E1BB75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15970", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15970", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15970:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15970:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09816", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09816", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179082", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TU70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB75", "url": "https://www.uniprot.org/uniprotkb/E1BB75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB75-1", "url": "https://www.uniprot.org/uniprotkb/E1BB75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPPLLPLGARKSLLGAGSSAVRSPQSRPPPRRVGPSSFPACAGGCRLGSPRAPERCPGSAAPPDAGAGGSGRGRARRAPGRARGPCGAMNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPPRPPQPSQPPPPPPMSFRAPTKPPAGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDSGPASPPQPCGGRPAVANGTGAARPPGSTQLMSTLRNDLQLSESGSDSDD", "length": 354, "header": "tr|E1BB75-1|E1BB75_BOVIN Isoform 1 of ELL associated factor 1 OS=Bos taurus OX=9913 GN=EAF1 PE=3 SV=2 CANONICAL=E1BB75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TU70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU70/entry", "sequence": { "sequence": "MAPPPLLPLGARKSLLGAGSSAVRSPQSRPPPRRVGPSSFPACAGGCRLGSPRAPERCPGSAAPPDAGAGGSGRGRARRAPGRARGPCGAMNGTANPLLDREEHCLRLGESFEKRPRASFHTIRCFLRLALPNASSEGHWTLLRPEPPRPLVTTERLRPHISFQLLCIPASPHPHRPTHNPIPALQELFSFPRDDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPPRPPQPSQPPPPPPMSFRAPTKPPAGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDSGPASPPQPCGGRPAVANGTGAARPPGSTQLMSTLRNDLQLSESGSDSDD", "length": 423, "header": "tr|A0AAA9TU70-1|E1BB75_BOVIN Computationally mapped isoform of ELL associated factor 1 OS=Bos taurus OX=9913 GN=EAF1 PE=3 SV=1 CANONICAL=E1BB75-1" }, "locus": { "chromosome": "1", "start_pos": 152462747, "end_pos": 152450841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118955.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118955.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100646.1" } ] } }, { "isoform_ac": "E1BB75-1", "url": "https://www.uniprot.org/uniprotkb/E1BB75/entry", "sequence": { "sequence": "MAPPPLLPLGARKSLLGAGSSAVRSPQSRPPPRRVGPSSFPACAGGCRLGSPRAPERCPGSAAPPDAGAGGSGRGRARRAPGRARGPCGAMNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPPRPPQPSQPPPPPPMSFRAPTKPPAGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDSGPASPPQPCGGRPAVANGTGAARPPGSTQLMSTLRNDLQLSESGSDSDD", "length": 354, "header": "tr|E1BB75-1|E1BB75_BOVIN Isoform 1 of ELL associated factor 1 OS=Bos taurus OX=9913 GN=EAF1 PE=3 SV=2 CANONICAL=E1BB75-1" }, "locus": { "chromosome": "1", "start_pos": 152462747, "end_pos": 152450841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025560.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025560.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025560.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025560.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507577", "resource": "KEGG Pathway" }, { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A2G7-1", "protein_name": "ELL associated factor 1", "gene_name": "Eaf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALPPLFPLGKRKSRPNTGSAAALLPQSLSRRRVDWFPAPGGRGLGSVRARELCPGSAGLRAARAGIRDCGRVRRAPIWVPGKCKAMNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPTRPPQPSQPPPPPPPMPFRAPTKPPAGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDDSSSSAGEDNGPASPPQPSHQQPYNSRPTVANGTSRPQGSAQLMNTLRNDLQLSESGSDSDD", "length": 355 }, "evidence": [ { "id": "E1BB75", "url": "https://omabrowser.org/oma/group/E1BB75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3L9Q7-1", "protein_name": "ELL associated factor 1", "gene_name": "EAF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPPPPLPLRDRKSLPGAGSSAAPLPHSCPPPRRARQDLFPAAGGHRLGSPLAPGCCPGSAAPSNSGAGSSGRGRARRAPGRARGPCGAMNGTANPLLDREEHRLRLGESFENRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPPRPPQPSQPPPPPLQPPPPPPPPPPMPFRAPTKPPAGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDNGPASPASHHQPYNSRPAVANGTGRPQGSTQLMSTLRNDLQLSESGSDSDD", "length": 365 }, "evidence": [ { "id": "E1BB75", "url": "https://omabrowser.org/oma/group/E1BB75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96JC9-1", "protein_name": "ELL-associated factor 1", "gene_name": "EAF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPTRPPQTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDNGPASPPQPSHQQPYNSRPAVANGTSRPQGSNQLMNTLRNDLQLSESGSDSDD", "length": 268 }, "evidence": [ { "id": "E1BB75", "url": "https://omabrowser.org/oma/group/E1BB75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D4C5-1", "protein_name": "ELL-associated factor 1", "gene_name": "Eaf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPARPPQPSQPPPPPPPMPFRAPTKPPAGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSAGEDNGPASPPQPSHQQPYNSRPAVANGTSRPQGSSQLMNTLRNDLQLSESGSDSDD", "length": 268 }, "evidence": [ { "id": "E1BB75", "url": "https://omabrowser.org/oma/group/E1BB75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription elongation by RNA polymerase II", "id": "GO:0006368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006368", "evidence": [ { "database": "UniProtKB", "id": "E1BB75", "url": "https://www.uniprot.org/uniprotkb/E1BB75" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "super elongation complex", "id": "GO:0032783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032783", "evidence": [ { "database": "UniProtKB", "id": "E1BB75", "url": "https://www.uniprot.org/uniprotkb/E1BB75" } ], "pmid": "" }, { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "E1BB75", "url": "https://www.uniprot.org/uniprotkb/E1BB75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription elongation factor activity", "id": "GO:0003711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003711", "evidence": [ { "database": "UniProtKB", "id": "E1BB75", "url": "https://www.uniprot.org/uniprotkb/E1BB75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB75" }, { "id": "PF09816", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09816" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transcription elongation factor Eaf N-terminal", "eco_id": "ECO_0000259", "start_pos": 106, "end_pos": 203, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 322, "end_pos": 324 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B705-1", "uniprot_ac": "E1B705", "uniprot_id": "E1B705_BOVIN", "mass": { "chemical_mass": 47533.0, "monoisotopic_mass": 47533.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ras association domain-containing protein 9", "type": "recommended", "evidence": [ { "id": "E1B705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B705/entry#names_and_taxonomy" } ] }, { "name": "PAM COOH-terminal interactor protein 1", "type": "synonym", "evidence": [ { "id": "E1B705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B705/entry#names_and_taxonomy" } ] }, { "name": "Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor", "type": "synonym", "evidence": [ { "id": "E1B705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B705/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in regulating vesicuar trafficking in cells.", "evidence": [ { "database": "UniProtKB", "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705#function" }, { "database": "UniProtKB", "id": "ARBA00053167", "url": "https://www.uniprot.org/uniprotkb/ARBA00053167#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B705", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000026966", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026966", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16133", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16133", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "E1B705", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1B705*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B705", "url": "https://www.orthodb.org/?gene=E1B705", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15286", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15286", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15286:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15286:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27976", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27976", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B705-1", "url": "https://www.uniprot.org/uniprotkb/E1B705-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSEEKEIVVWVCQEEKIVCGLTKRTTSADVIQALLEEHETTFGEKRFLLGNPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSQERDSMETLVHLIISQDHTINQQVKRMKELDLEIEKCEAKFHLDRVENNGENYVQDAYLMPSFSEVEQKLGLEYDERQMLEDLRESNGIVQLEERLTYYRKLIDKLSAEIEKEVKSVCMEINEDAEGAAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHISNADDCQLKENRGKESEVPTSNGVVSPFTQRIFNMYTNDTDSDTGISSNHSQDSETTAGDVVLLST", "length": 414, "header": "tr|E1B705-1|E1B705_BOVIN Isoform 1 of Ras association domain-containing protein 9 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B705-1" }, "isoforms": [ { "isoform_ac": "E1B705-1", "url": "https://www.uniprot.org/uniprotkb/E1B705/entry", "sequence": { "sequence": "MDSEEKEIVVWVCQEEKIVCGLTKRTTSADVIQALLEEHETTFGEKRFLLGNPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSQERDSMETLVHLIISQDHTINQQVKRMKELDLEIEKCEAKFHLDRVENNGENYVQDAYLMPSFSEVEQKLGLEYDERQMLEDLRESNGIVQLEERLTYYRKLIDKLSAEIEKEVKSVCMEINEDAEGAAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHISNADDCQLKENRGKESEVPTSNGVVSPFTQRIFNMYTNDTDSDTGISSNHSQDSETTAGDVVLLST", "length": 414, "header": "tr|E1B705-1|E1B705_BOVIN Isoform 1 of Ras association domain-containing protein 9 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B705-1" }, "locus": { "chromosome": "5", "start_pos": 15469637, "end_pos": 15468396, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101268.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101268.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089841.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089841.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "trans-Golgi network transport vesicle membrane", "id": "GO:0012510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012510", "evidence": [ { "database": "UniProtKB", "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1B705", "url": "https://www.uniprot.org/uniprotkb/E1B705" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B705" }, { "id": "PS50200", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-associating", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 98, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 386, "end_pos": 388 }, { "start_pos": 397, "end_pos": 399 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7APV1-1", "uniprot_ac": "A0AAF7APV1", "uniprot_id": "A0AAF7APV1_BOVIN", "mass": { "chemical_mass": 41336.0, "monoisotopic_mass": 41336.0 }, "refseq": { "ac": "XP_059737306", "name": "N-acetylglucosamine-6-phosphate deacetylase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737306" }, "gene_names": [ { "name": "AMDHD2", "type": "recommended", "evidence": [ { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ] }, { "name": "AMDHD2", "type": "synonym", "evidence": [ { "id": "XP_059737306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737306" } ] } ], "protein_names": [ { "name": "N-acetylglucosamine-6-phosphate deacetylase", "type": "recommended", "evidence": [ { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.25", "type": "synonym", "evidence": [ { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1/entry#names_and_taxonomy" } ] }, { "name": "N-acetylglucosamine-6-phosphate deacetylase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059737306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737306" } ] } ], "function": [ { "annotation": "Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TED9#function" }, { "database": "UniProtKB", "id": "PIRNR038994", "url": "https://www.uniprot.org/uniprotkb/PIRNR038994#function" }, { "database": "UniProtKB", "id": "A0AAA9TLX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX5#function" }, { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AMDHD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1", "locus": { "chromosome": "25", "start_pos": 2024928, "end_pos": 2018074, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001022", "url": "https://www.ensembl.org/id/ENSBTAG00000001022" } ] } } ], "crossref": [ { "id": "A0AAF7APV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7APV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00854", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00854", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521401", "url": "https://www.ncbi.nlm.nih.gov/gene/521401", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11113:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11113:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059737306", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737306", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22936", "url": "https://www.rhea-db.org/rhea/22936", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TED9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TED9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TED9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7APV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGGQGAARAPVIQFTNCRILRGGALLREDLWVRGGRILDPEKLFFEERRVADEQRDCGGCILAPGFIDVQINGGFGVDFSQASEDVGSGVALVARRILSHGVTSFCPTLVTSPLEVYHKVLPQIPVKSGGPHGAGVLGVHLEGPFISREKRGAHPEAHLRSFEADAFQDVLATYGGLDNVRIVTLAPELGHSQEVIRALTALGICVSLGHSVADLGTAEEAVQSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRHIFYGMIADGIHTNPAALRIAHRAHPKGLVLVTDAVPALGLGNGRHTLGQQEVEVDGLTAYVAGTNTLSGSIAPMDTCVRHFLQATGMWPGSRLQEVASAGEGGANQQGAGTQSDWPWSHSTQGWGPVRL", "length": 390, "header": "tr|A0AAF7APV1-1|A0AAF7APV1_BOVIN Isoform 1 of N-acetylglucosamine-6-phosphate deacetylase OS=Bos taurus OX=9913 GN=AMDHD2 PE=3 SV=2 CANONICAL=A0AAF7APV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TED9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TED9/entry", "sequence": { "sequence": "MRGGQGAARAPVIQFTNCRILRGGALLREDLWVRGGRILDPEKLFFEERRVADEQRDCGGCILAPGFIDVQINGGFGVDFSQASEDVGSGVALVARRILSHGVTSFCPTLVTSPLEVYHKVLPQIPVKSGGPHGAGVLGVHLEGPFISREKRGAHPEAHLRSFEADAFQDVLATYGGLDNVRIVTLAPELGHSQEVIRALTALGICVSLGHSVADLGTAEEAVQSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRHIFYGMIADGIHTNPAALRIAHRAHPKGLVLVTDAVPALGLGNGRHTLGQQEVEVDGLTAYVAGCSVESALEAASLHPAQLLGLEKRKGTLDFGADADFVVLDDSLHVRATYISGELVWQVEEARP", "length": 386, "header": "tr|A0AAA9TED9-1|A0AAF7APV1_BOVIN Computationally mapped isoform of N-acetylglucosamine-6-phosphate deacetylase OS=Bos taurus OX=9913 GN=AMDHD2 PE=3 SV=1 CANONICAL=A0AAF7APV1-1" }, "locus": { "chromosome": "25", "start_pos": 2024772, "end_pos": 2018273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127002.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127002.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096506.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096506.1" } ] } }, { "isoform_ac": "A0AAA9TLX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX5/entry", "sequence": { "sequence": "MRGGQGAARAPVIQFTNCRILRGGALLREDLWVRGGRILDPEKLFFEERRVADEQRDCGGCILAPGFIDVQINGGFGVDFSQASEDVGSGVALVARRILSHGVTSFCPTLVTSPLEVYHKVLPQIPVKSGGPHGAGVLGVHLEGPFISREKRGAHPEAHLRSFEADAFQDVLATYGGLDNVRIVTLAPELGHSQEVIRALTALGICVSLGHSVADLGTAEEAVQSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRHIFYGMIADGIHTNPAALRIAHRAHPKGTNTLSGSIAPMDTCVRHFLQATGCSVESALEAASLHPAQLLGLEKRKGTLDFGADADFVVLDDSLHVRATYISGELVWQVEEARP", "length": 373, "header": "tr|A0AAA9TLX5-1|A0AAF7APV1_BOVIN Computationally mapped isoform of N-acetylglucosamine-6-phosphate deacetylase OS=Bos taurus OX=9913 GN=AMDHD2 PE=3 SV=1 CANONICAL=A0AAF7APV1-1" }, "locus": { "chromosome": "25", "start_pos": 2024772, "end_pos": 2018273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116641.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116641.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097958.1" } ] } }, { "isoform_ac": "A0AAF7APV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1/entry", "sequence": { "sequence": "MRGGQGAARAPVIQFTNCRILRGGALLREDLWVRGGRILDPEKLFFEERRVADEQRDCGGCILAPGFIDVQINGGFGVDFSQASEDVGSGVALVARRILSHGVTSFCPTLVTSPLEVYHKVLPQIPVKSGGPHGAGVLGVHLEGPFISREKRGAHPEAHLRSFEADAFQDVLATYGGLDNVRIVTLAPELGHSQEVIRALTALGICVSLGHSVADLGTAEEAVQSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRHIFYGMIADGIHTNPAALRIAHRAHPKGLVLVTDAVPALGLGNGRHTLGQQEVEVDGLTAYVAGTNTLSGSIAPMDTCVRHFLQATGMWPGSRLQEVASAGEGGANQQGAGTQSDWPWSHSTQGWGPVRL", "length": 390, "header": "tr|A0AAF7APV1-1|A0AAF7APV1_BOVIN Isoform 1 of N-acetylglucosamine-6-phosphate deacetylase OS=Bos taurus OX=9913 GN=AMDHD2 PE=3 SV=2 CANONICAL=A0AAF7APV1-1" }, "locus": { "chromosome": "25", "start_pos": 2023654, "end_pos": 2018273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074115.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074115.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072880.3", "url": "https://www.ensembl.org/id/ENSBTAP00000072880.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "N-acetylglucosamine metabolic process", "id": "GO:0006044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006044", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "pmid": "" }, { "name": "N-acetylneuraminate catabolic process", "id": "GO:0019262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019262", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "pmid": "" }, { "name": "negative regulation of UDP-N-acetylglucosamine biosynthetic process", "id": "GO:0106279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106279", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "N-acetylglucosamine-6-phosphate deacetylase activity", "id": "GO:0008448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008448", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7APV1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22936", "name": "", "equation": "N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF7APV1-1", "A7MBC0-1" ], "evidence": [ { "id": "22936", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22936" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF7APV1", "gene_name": "AMDHD2", "activity": [ { "ec_number": "3.5.1.25", "activity": "N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.", "evidence": [ { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ] }, { "ec_number": "3.5.1.25", "activity": "", "evidence": [ { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ] } ] }, { "uniprot_ac": "A7MBC0", "gene_name": "AMDHD2", "activity": [ { "ec_number": "3.5.1.25", "activity": "N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.", "evidence": [ { "id": "A7MBC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBC0" } ] }, { "ec_number": "3.5.1.25", "activity": "", "evidence": [ { "id": "A7MBC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBC0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "PIRSR038994-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038994-3" }, { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "binding_site_uniprot": 143, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 143, "end_pos": 143, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR038994-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038994-3" }, { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "binding_site_uniprot": 211, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 211, "end_pos": 211, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR038994-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038994-3" }, { "id": "A0AAF7APV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7APV1" } ], "binding_site_uniprot": 232, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 232, "end_pos": 232, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.1.25", "ec_name": "N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.", "evidence": [ { "id": "3.5.1.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9I7-1", "uniprot_ac": "E1B9I7", "uniprot_id": "E1B9I7_BOVIN", "mass": { "chemical_mass": 28130.0, "monoisotopic_mass": 28130.0 }, "refseq": { "ac": "XP_005208474", "name": "DNA-binding protein RFXANK isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208474" }, "gene_names": [ { "name": "RFXANK", "type": "recommended", "evidence": [ { "id": "E1B9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ] }, { "name": "RFXANK", "type": "synonym", "evidence": [ { "id": "XP_005208474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208474" } ] } ], "protein_names": [ { "name": "DNA-binding protein RFXANK isoform X4", "type": "synonym", "evidence": [ { "id": "XP_005208474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208474" } ] }, { "name": "Regulatory factor X associated ankyrin containing protein", "type": "synonym", "evidence": [ { "id": "E1B9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9I7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RFXANK", "url": "https://www.uniprot.org/uniprotkb/E1B9I7", "locus": { "chromosome": "7", "start_pos": 4059616, "end_pos": 4065645, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001762", "url": "https://www.ensembl.org/id/ENSBTAG00000001762" } ] } } ], "crossref": [ { "id": "E1B9I7", "url": "https://alphafold.ebi.ac.uk/entry/E1B9I7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001762", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001762", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100125917", "url": "https://www.ncbi.nlm.nih.gov/gene/100125917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MI09", "url": "https://www.orthodb.org/?gene=A0A3Q1MI09", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9I7", "url": "https://www.orthodb.org/?gene=E1B9I7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24124:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24124:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208474", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208474", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI09", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9I7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9I7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHTQPAEDLSLTQQPLTPEFGDPEDPRDEAPDGSDTVVLSLFPCTPEPGNPESDAGSSSPQGNSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELSQLKEHLRKGDNLINKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE", "length": 259, "header": "tr|E1B9I7-1|E1B9I7_BOVIN Isoform 1 of Regulatory factor X associated ankyrin containing protein OS=Bos taurus OX=9913 GN=RFXANK PE=4 SV=2 CANONICAL=E1B9I7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MI09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI09/entry", "sequence": { "sequence": "MEHTQPAEDLSLTQQPLTPEFGDPEDPRDEAPDGSDTVVLSLFPCTPEPGNPESDAGSSSPQGNSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELSQLKEHLRKGDNLINKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLETLEVEIPVATCIKSGSSPGPHSYQQTRGCVPEELISPLRQTPATPRWTSPWPWDIGKCNR", "length": 270, "header": "tr|A0A3Q1MI09-1|E1B9I7_BOVIN Computationally mapped isoform of Regulatory factor X associated ankyrin containing protein OS=Bos taurus OX=9913 GN=RFXANK PE=4 SV=2 CANONICAL=E1B9I7-1" }, "locus": { "chromosome": "7", "start_pos": 4064145, "end_pos": 4059823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077838.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077838.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070348.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070348.2" } ] } }, { "isoform_ac": "A0AAA9T9L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L4/entry", "sequence": { "sequence": "MEHTQPAEDLSLTQQPLTPEFGDPEDPRDEAPDGSDTVVLSLFPCTPEPGNPESDAGSSSPQGNSLKHSTTLTNRQRGNEVSALPATLDCDNLINKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE", "length": 237, "header": "tr|A0AAA9T9L4-1|E1B9I7_BOVIN Computationally mapped isoform of Regulatory factor X associated ankyrin containing protein OS=Bos taurus OX=9913 GN=RFXANK PE=4 SV=1 CANONICAL=E1B9I7-1" }, "locus": { "chromosome": "7", "start_pos": 4064145, "end_pos": 4059764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094851.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094851.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095398.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095398.1" } ] } }, { "isoform_ac": "E1B9I7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9I7/entry", "sequence": { "sequence": "MEHTQPAEDLSLTQQPLTPEFGDPEDPRDEAPDGSDTVVLSLFPCTPEPGNPESDAGSSSPQGNSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELSQLKEHLRKGDNLINKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE", "length": 259, "header": "tr|E1B9I7-1|E1B9I7_BOVIN Isoform 1 of Regulatory factor X associated ankyrin containing protein OS=Bos taurus OX=9913 GN=RFXANK PE=4 SV=2 CANONICAL=E1B9I7-1" }, "locus": { "chromosome": "7", "start_pos": 4064145, "end_pos": 4059764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002309.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002309.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002309.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002309.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1B9I7", "url": "https://www.uniprot.org/uniprotkb/E1B9I7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N126-1", "uniprot_ac": "F1N126", "uniprot_id": "F1N126_BOVIN", "mass": { "chemical_mass": 53204.0, "monoisotopic_mass": 53204.0 }, "refseq": {}, "gene_names": [ { "name": "SMOC2", "type": "recommended", "evidence": [ { "id": "F1N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ] } ], "protein_names": [ { "name": "SPARC related modular calcium binding 2", "type": "synonym", "evidence": [ { "id": "F1N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N126/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMOC2", "url": "https://www.uniprot.org/uniprotkb/F1N126", "locus": { "chromosome": "9", "start_pos": 102803012, "end_pos": 102645195, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013176", "url": "https://www.ensembl.org/id/ENSBTAG00000013176" } ] } } ], "crossref": [ { "id": "F1N126", "url": "https://alphafold.ebi.ac.uk/entry/F1N126", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013176", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013176", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00191", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00191", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615490", "url": "https://www.ncbi.nlm.nih.gov/gene/615490", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MID9", "url": "https://www.orthodb.org/?gene=A0A3Q1MID9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N126", "url": "https://www.orthodb.org/?gene=F1N126", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12352:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12352:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10591", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10591", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16597", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16597", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LJM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MID9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MID9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MID9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MID9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4B9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4B9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N126-1", "url": "https://www.uniprot.org/uniprotkb/F1N126-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLPRLCWLPLLAALLPPAPAQKFSALTFLRVDQDKDKDCSLDCGGSAQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARRELQQVFIPECSDDGTYSQVQCHSYTGYCWCVTPNGRPIGGTAVAHKTPRCPGSINEKVPQREGTGKTDDASAPALETQPQGDEEDVASRYPTLWTEQVKSRQNKTNKNSVSSCDQEQQSALEEARQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPVRTRDLYKSRQLQGCPGAKKREFLTSVLDALSTDMVHAVSDPSSPGRLSEPDPSHTLEERVVHWYFKLLDKNNSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISLQELMGCLGATREEVKADTRKRHTPRGNAESTSNRQKVKHLPRKKQMQTFIFHRVPPPKGLSASRPVLKN", "length": 474, "header": "tr|F1N126-1|F1N126_BOVIN Isoform 1 of SPARC related modular calcium binding 2 OS=Bos taurus OX=9913 GN=SMOC2 PE=4 SV=4 CANONICAL=F1N126-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJM6/entry", "sequence": { "sequence": "MLLPRLCWLPLLAALLPPAPAQKFSALTFLRVDQDKDKDCSLDCGGSAQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARRELQQVFIPECSDDGTYSQVQCHSYTGYCWCVTPNGRPIGGTAVAHKTPRCPGSINEKVPQREGTGKTVSLQIFSVLNSDDASAPALETQPQGDEEDVASRYPTLWTEQVKSRQNKTNKNSVSSCDQEQQSALEEARQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPVRTRDLYKSRQLQGCPGAKKREFLTSVLDALSTDMVHAVSDPSSPGRLSEPDPSHTLEERVVHWYFKLLDKNNSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISLQELMGCLGATREEVKADTRKRHTPRGNAESTSNRQPRKQG", "length": 456, "header": "tr|A0A3Q1LJM6-1|F1N126_BOVIN Computationally mapped isoform of SPARC related modular calcium binding 2 OS=Bos taurus OX=9913 GN=SMOC2 PE=4 SV=1 CANONICAL=F1N126-1" }, "locus": { "chromosome": "9", "start_pos": 102801554, "end_pos": 102645377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074522.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074522.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056754.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056754.2" } ] } }, { "isoform_ac": "A0A3Q1MID9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MID9/entry", "sequence": { "sequence": "MLLPRLCWLPLLAALLPPAPAQKFSALTFLRVDQDKDKDCSLDCGGSAQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARRELQQVFIPECSDDGTYSQVQCHSYTGYCWCVTPNGRPIGGTAVAHKTPRCPGSINEKVPQREGTGKTDDASAPALETQPQGDEEDVASRYPTLWTEQVKSRQNKTNKNSVSSCDQEQQSALEEARQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPVRTRDLYKSRQLQGCPGAKKREFLTSVLDALSTDMVHAVSDPSSPGRLSEPDPSHTLEERVVHWYFKLLDKNNSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISLQELMGCLGATREEVKADTRKRHTQHLLSL", "length": 434, "header": "tr|A0A3Q1MID9-1|F1N126_BOVIN Computationally mapped isoform of SPARC related modular calcium binding 2 OS=Bos taurus OX=9913 GN=SMOC2 PE=4 SV=2 CANONICAL=F1N126-1" }, "locus": { "chromosome": "9", "start_pos": 102797879, "end_pos": 102645377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080589.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080589.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071032.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071032.2" } ] } }, { "isoform_ac": "A0AAA9T4B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4B9/entry", "sequence": { "sequence": "MLLPRLCWLPLLAALLPPAPAQKFSALTFLRVDQDKDKDCSLDCGGSAQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARRELQQVFIPECSDDGTYSQVQCHSYTGYCWCVTPNGRPIGGTAVAHKTPRCPDDASAPALETQPQGDEEDVASRYPTLWTEQVKSRQNKTNKNSVSSCDQEQQSALEEARQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPVRTRDLYKSRQLQGCPGAKKREFLTSVLDALSTDMVHAVSDPSSPGRLSEPDPSHTLEERVVHWYFKLLDKNNSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISLQELMGCLGATREEVKADTRKRHTPRGNAESTSNRQPRKQG", "length": 429, "header": "tr|A0AAA9T4B9-1|F1N126_BOVIN Computationally mapped isoform of SPARC related modular calcium binding 2 OS=Bos taurus OX=9913 GN=SMOC2 PE=4 SV=1 CANONICAL=F1N126-1" }, "locus": { "chromosome": "9", "start_pos": 102801554, "end_pos": 102645377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103526.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103526.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090571.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090571.1" } ] } }, { "isoform_ac": "A0AAA9TRQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRQ8/entry", "sequence": { "sequence": "MLLPRLCWLPLLAALLPPAPAQKFSALTFLRVDQDKDKDCSLDCGGSAQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARRELQQVFIPECSDDGTYSQVQCHSYTGYCWCVTPNGRPIGGTAVAHKTPRCPGSINEKVPQREGTGKTDDASAPALETQPQGDEEDVASRYPTLWTEQVKSRQNKTNKNSVSSCDQEQQSALEEARQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPVRTRDLYKSRQLQGCPGAKKREFLTSVLDALSTDMVHAVSDPSSPGRLSEPDPSHTLEERVVHWYFKLLDKNNSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISLQELMGCLGATREEVKADTRKRHTKEARIDDSTTGPRHVANSLTKKQLKKTKQTHSICTLYFNCKFTL", "length": 472, "header": "tr|A0AAA9TRQ8-1|F1N126_BOVIN Computationally mapped isoform of SPARC related modular calcium binding 2 OS=Bos taurus OX=9913 GN=SMOC2 PE=4 SV=1 CANONICAL=F1N126-1" }, "locus": { "chromosome": "9", "start_pos": 102801673, "end_pos": 102645377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103685.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103685.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101057.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101057.1" } ] } }, { "isoform_ac": "F1N126-1", "url": "https://www.uniprot.org/uniprotkb/F1N126/entry", "sequence": { "sequence": "MLLPRLCWLPLLAALLPPAPAQKFSALTFLRVDQDKDKDCSLDCGGSAQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARRELQQVFIPECSDDGTYSQVQCHSYTGYCWCVTPNGRPIGGTAVAHKTPRCPGSINEKVPQREGTGKTDDASAPALETQPQGDEEDVASRYPTLWTEQVKSRQNKTNKNSVSSCDQEQQSALEEARQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPVRTRDLYKSRQLQGCPGAKKREFLTSVLDALSTDMVHAVSDPSSPGRLSEPDPSHTLEERVVHWYFKLLDKNNSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISLQELMGCLGATREEVKADTRKRHTPRGNAESTSNRQKVKHLPRKKQMQTFIFHRVPPPKGLSASRPVLKN", "length": 474, "header": "tr|F1N126-1|F1N126_BOVIN Isoform 1 of SPARC related modular calcium binding 2 OS=Bos taurus OX=9913 GN=SMOC2 PE=4 SV=4 CANONICAL=F1N126-1" }, "locus": { "chromosome": "9", "start_pos": 102799123, "end_pos": 102645377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044700.6", "url": "https://www.ensembl.org/id/ENSBTAT00000044700.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042177.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042177.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of vascular wound healing", "id": "GO:0035470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035470", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell chemotaxis", "id": "GO:2001028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001028", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle", "id": "GO:0045931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045931", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" }, { "name": "positive regulation of DNA biosynthetic process", "id": "GO:2000573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000573", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" }, { "name": "positive regulation of vascular endothelial growth factor signaling pathway", "id": "GO:1900748", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900748", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" }, { "name": "positive regulation of fibroblast growth factor receptor signaling pathway", "id": "GO:0045743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045743", "evidence": [ { "database": "UniProtKB", "id": "F1N126", "url": "https://www.uniprot.org/uniprotkb/F1N126" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N126-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 474, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N126-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N126" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N126" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 346, "end_pos": 381, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N126" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 86, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N126" }, { "id": "PS51162", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51162" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thyroglobulin type-1", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 153, "start_aa": "Val", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 361, "end_pos": 363 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0L0-1", "uniprot_ac": "F1N0L0", "uniprot_id": "F1N0L0_BOVIN", "mass": { "chemical_mass": 177344.0, "monoisotopic_mass": 177344.0 }, "refseq": { "ac": "XP_024846896", "name": "E3 ubiquitin-protein ligase HECW1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846896" }, "gene_names": [ { "name": "HECW1", "type": "recommended", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ] }, { "name": "HECW1", "type": "synonym", "evidence": [ { "id": "XP_024846896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846896" } ] } ], "protein_names": [ { "name": "HECT-type E3 ubiquitin transferase", "type": "recommended", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.26", "type": "synonym", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase HECW1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024846896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846896" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HECW1", "url": "https://www.uniprot.org/uniprotkb/F1N0L0", "locus": { "chromosome": "4", "start_pos": 77538822, "end_pos": 77987317, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021216", "url": "https://www.ensembl.org/id/ENSBTAG00000021216" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021216", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021216", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08691", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08691", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514243", "url": "https://www.ncbi.nlm.nih.gov/gene/514243", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLU3", "url": "https://www.orthodb.org/?gene=A0A3Q1MLU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0L0", "url": "https://www.orthodb.org/?gene=F1N0L0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18436", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18436", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-4641258", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024846896", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846896", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLU3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLHLCSVKNLYQNRFLGLAAMASPSRNSQNRRRCKEPLRHSYNPGQYHSVAIRTGPHGAVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGSDETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAEIQDSPMNNLVASSCGEPPCDAPEPSGTPKPEQPSQGSTVGPPEIEGLELTSLVEAAAGTTEAGDDDGIVSVGPEGAGELLAPGPEDTEPALSAEELAERLDLGGEVALPGMLEDGQAPSSPGEPVAEERATESRAGGQEEEKEQMEEEEGDVSALGQGEDRLHLRASVKRKTRPCSLPVSELETVIASACGEPETPRTHYIRIHTLLHSLPSAQGGSADDDDDGAEEEATLKDASEKDALSEMDTVAAEPPPLEEDGEAPEGATPGTAPLGHSGLANGSAPDGDALPSTGSESDSSPRQGGDHSCCDASCCSPSCYSSSCYSSSCYSASCYSPSCYNGSRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSVQSPELDQESANGAGPWQDELAAPDGSMARTMEGLESPVAGPSSRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERPEEDSGSQICDPVPAGGGGGGGSDSEAESSSLDLRRDGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHDSLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVRWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE", "length": 1595, "header": "tr|F1N0L0-1|F1N0L0_BOVIN Isoform 1 of HECT-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=HECW1 PE=4 SV=4 CANONICAL=F1N0L0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU3/entry", "sequence": { "sequence": "MLLHLCSVKNLYQNRFLGLAAMASPSRNSQNRRRCKEPLRHSYNPGQYHSVAIRTGPHGAVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGSDETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAEIQDSPMNNLVASSCGEPPCDAPEPSGTPKPEQPSQGSTVGPPEIEGLELTSLVEAAAGTTEAGDDDGIVSVGPEGAGELLAPGPEDTEPALSAEELAERLDLGGEVALPGMLEDGQAPSSPGEPVAEERATESRAGGQEEEKEQMEEEEGDVSALGQGEDRLHLRASVKRKTRPCSLPVSELETVIASACGEPETPRTHYIRIHTLLHSLPSAQGGSADDDDDGAEEEATLKDASEKDALSEMDTVAAEPPPLEEDGEAPEGATPGTAPLGHSGLANGSAPDGDALPSTGSESDSSPRQGGDHSCCDASCCSPSCYSSSCYSSSCYSASCYSPSCYNGSRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSVQSPELDQESANGAGPWQDELAAPDGSMARTMEGLESPVAGPSSRREDWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERPEEDSGSQICDPVPAGGGGGGGSDSEAESSSLDLRRDGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHDSLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVRWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE", "length": 1561, "header": "tr|A0A3Q1MLU3-1|F1N0L0_BOVIN Computationally mapped isoform of HECT-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=HECW1 PE=4 SV=2 CANONICAL=F1N0L0-1" }, "locus": { "chromosome": "4", "start_pos": 77863493, "end_pos": 77539354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082498.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082498.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072040.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072040.2" } ] } }, { "isoform_ac": "F1N0L0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L0/entry", "sequence": { "sequence": "MLLHLCSVKNLYQNRFLGLAAMASPSRNSQNRRRCKEPLRHSYNPGQYHSVAIRTGPHGAVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGSDETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAEIQDSPMNNLVASSCGEPPCDAPEPSGTPKPEQPSQGSTVGPPEIEGLELTSLVEAAAGTTEAGDDDGIVSVGPEGAGELLAPGPEDTEPALSAEELAERLDLGGEVALPGMLEDGQAPSSPGEPVAEERATESRAGGQEEEKEQMEEEEGDVSALGQGEDRLHLRASVKRKTRPCSLPVSELETVIASACGEPETPRTHYIRIHTLLHSLPSAQGGSADDDDDGAEEEATLKDASEKDALSEMDTVAAEPPPLEEDGEAPEGATPGTAPLGHSGLANGSAPDGDALPSTGSESDSSPRQGGDHSCCDASCCSPSCYSSSCYSSSCYSASCYSPSCYNGSRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSVQSPELDQESANGAGPWQDELAAPDGSMARTMEGLESPVAGPSSRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERPEEDSGSQICDPVPAGGGGGGGSDSEAESSSLDLRRDGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHDSLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVRWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE", "length": 1595, "header": "tr|F1N0L0-1|F1N0L0_BOVIN Isoform 1 of HECT-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=HECW1 PE=4 SV=4 CANONICAL=F1N0L0-1" }, "locus": { "chromosome": "4", "start_pos": 77863493, "end_pos": 77539354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028268.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028268.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028268.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028268.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 627, "start_aa": "Thr", "end_pos": 627, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr627", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "pmid": "" }, { "name": "regulation of dendrite morphogenesis", "id": "GO:0048814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048814", "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N0L0", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1131, "end_pos": 1133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1309, "end_pos": 1311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1387, "end_pos": 1389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1486, "end_pos": 1488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 640, "end_pos": 642, "annotation": "n_glycosylation_sequon" }, { "start_pos": 700, "end_pos": 702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 959, "end_pos": 961, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0L0-1" ], "evidence": [ { "id": "R-BTA-4641155", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641155" } ] }, { "id": "R-BTA-4641159", "name": "DVL1 is ubiquitinated by HECW1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0L0-1" ], "evidence": [ { "id": "R-BTA-4641159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641159" } ] }, { "id": "R-BTA-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "F1N0L0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-4641260", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641260" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1N0L0", "gene_name": "HECW1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ] } ] }, { "uniprot_ac": "Q32KL2", "gene_name": "PSMB5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q32KL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q32KL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ] } ] }, { "uniprot_ac": "Q3MHN0", "gene_name": "PSMB6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q3MHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHN0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q3MHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHN0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 182, "end_pos": 318, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 1260, "end_pos": 1595, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 820, "end_pos": 853, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.26", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.26" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 627 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1131, "end_pos": 1133 }, { "start_pos": 1309, "end_pos": 1311 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 1387, "end_pos": 1389 }, { "start_pos": 1486, "end_pos": 1488 }, { "start_pos": 640, "end_pos": 642 }, { "start_pos": 700, "end_pos": 702 }, { "start_pos": 843, "end_pos": 845 }, { "start_pos": 959, "end_pos": 961 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9Q1-1", "uniprot_ac": "E1B9Q1", "uniprot_id": "E1B9Q1_BOVIN", "mass": { "chemical_mass": 63354.0, "monoisotopic_mass": 63354.0 }, "refseq": { "ac": "NP_001179398", "name": "F-box/WD repeat-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179398" }, "gene_names": [ { "name": "FBXW5", "type": "recommended", "evidence": [ { "id": "E1B9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ] }, { "name": "FBXW5", "type": "synonym", "evidence": [ { "id": "NP_001179398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179398" } ] } ], "protein_names": [ { "name": "F-box/WD repeat-containing protein 5", "type": "recommended", "evidence": [ { "id": "E1B9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1/entry#names_and_taxonomy" } ] }, { "name": "F-box and WD-40 domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "E1B9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1/entry#names_and_taxonomy" } ] }, { "name": "F-box/WD repeat-containing protein 5", "type": "synonym", "evidence": [ { "id": "NP_001179398", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179398" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXW5", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1", "locus": { "chromosome": "11", "start_pos": 105981080, "end_pos": 105985321, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010515", "url": "https://www.ensembl.org/id/ENSBTAG00000010515" } ] } } ], "crossref": [ { "id": "E1B9Q1", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010515", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010515", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22132", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22132", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517357", "url": "https://www.ncbi.nlm.nih.gov/gene/517357", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517357", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517357", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NPRDSEM", "url": "https://omabrowser.org/oma/group/NPRDSEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MN48", "url": "https://www.orthodb.org/?gene=A0A3Q1MN48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9Q1", "url": "https://www.orthodb.org/?gene=E1B9Q1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20995", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20995", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20995:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20995:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179398", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN48", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEGETPLLPDSLVYQIFLSLGPADVLAAGLACRQWQAVSRDECLWREQFYRYYQVARDVPRHPAATSWFEEFRRLYDAVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDPTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDTFALLSRVRNKPYDVFGCWLTDTSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDAGAPGTDSSRVFDLGSDGEDEESDPGPARAKGLRRLLDGFLEGRAQPPLPESTLETKVAKLLAQGHTKPPEQGRAAAGNKLLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPSGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTVRVLQAPRPRPRPFFSWFASQKH", "length": 565, "header": "tr|E1B9Q1-1|E1B9Q1_BOVIN Isoform 1 of F-box/WD repeat-containing protein 5 OS=Bos taurus OX=9913 GN=FBXW5 PE=3 SV=1 CANONICAL=E1B9Q1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MN48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN48/entry", "sequence": { "sequence": "MDEGETPLLPDSLVYQIFLSLGPADVLAAGLACRQWQAVSRDECLWREQFYRYYQVARDVPRHPAATSWFEEFRRLYDAVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDPTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLGKRGLGAGGPTTPPLTLHPLPRHLRPTPPAPPAPPLPSAPPDTFALLSRVRNKPYDVFGCWLTDTSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDAGAPGTDSSRVFDLGSDGEDEESDPGPARAKGLRRLLDGFLEGRAQPPLPESTLETKVAKLLAQGHTKPPEQGRAAAGNKLLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPSGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTVRVLQAPRPRPRPFFSWFASQKH", "length": 606, "header": "tr|A0A3Q1MN48-1|E1B9Q1_BOVIN Computationally mapped isoform of F-box/WD repeat-containing protein 5 OS=Bos taurus OX=9913 GN=FBXW5 PE=3 SV=2 CANONICAL=E1B9Q1-1" }, "locus": { "chromosome": "11", "start_pos": 105984249, "end_pos": 105981583, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078511.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078511.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072648.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072648.2" } ] } }, { "isoform_ac": "E1B9Q1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1/entry", "sequence": { "sequence": "MDEGETPLLPDSLVYQIFLSLGPADVLAAGLACRQWQAVSRDECLWREQFYRYYQVARDVPRHPAATSWFEEFRRLYDAVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDPTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDTFALLSRVRNKPYDVFGCWLTDTSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDAGAPGTDSSRVFDLGSDGEDEESDPGPARAKGLRRLLDGFLEGRAQPPLPESTLETKVAKLLAQGHTKPPEQGRAAAGNKLLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPSGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTVRVLQAPRPRPRPFFSWFASQKH", "length": 565, "header": "tr|E1B9Q1-1|E1B9Q1_BOVIN Isoform 1 of F-box/WD repeat-containing protein 5 OS=Bos taurus OX=9913 GN=FBXW5 PE=3 SV=1 CANONICAL=E1B9Q1-1" }, "locus": { "chromosome": "11", "start_pos": 105984249, "end_pos": 105981583, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013887.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013887.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013887.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013887.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517357", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517357", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "G3IHB8-1", "protein_name": "F-box/WD repeat-containing protein 5", "gene_name": "Fbxw5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDEGGMPLLPDSLIYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWSNDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDAGDQAGLPCRVFDLGGDSEEEAPDPGLHTSGSGRVKEGVRHMLDNVLDGHAQLTDCALETKVAELLAQGHTKPPECSDADTRNKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPPGSVVVDPMQPPPIAEEIDLLVFDLKTMREVKRALRAHHAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTVRVLQAPRPRPRPFFSWFASHRR", "length": 569 }, "evidence": [ { "id": "E1B9Q1", "url": "https://omabrowser.org/oma/group/E1B9Q1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4KLI9-1", "protein_name": "F-box/WD repeat-containing protein 5", "gene_name": "Fbxw5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDEGGMPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDVTSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDAGDQAGLPCRVFDLGGDTEEEATDPGLHTSGSGHVKEGLRRVFDSVLDGHGQLSDCALETKVAELLAQGHTKPPECPDADSRNKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPPGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVAFSPQEQELLLTASDDATIKAWRSPRIVRVLQAPHPRPRPFFSWFASHRR", "length": 569 }, "evidence": [ { "id": "E1B9Q1", "url": "https://omabrowser.org/oma/group/E1B9Q1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q969U6-1", "protein_name": "F-box/WD repeat-containing protein 5", "gene_name": "FBXW5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDEGGTPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAAMSWYEEFQRLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWSNDLTISLLHSADMRPYNWSYTQFSQFNKDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTVRTVMVADCSRFDSPDLLLEAGDPATSPCRIFDLGSDNEEVVAGPAPAHAKEGLRHFLDRVLEGRAQPQLSERMLETKVAELLAQGHTKPPERSATGAKSKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDIHGHIIGMGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVRRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVLQAPRPRPRTFFSWLASQRR", "length": 566 }, "evidence": [ { "id": "E1B9Q1", "url": "https://omabrowser.org/oma/group/E1B9Q1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QXW2-1", "protein_name": "F-box/WD repeat-containing protein 5", "gene_name": "Fbxw5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEGGLPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWKEQFYRYYQVARDVPRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWNNDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRTVMVADCSRFDSPDLLLDASDQAGLPCRVFDLGGDTEEEATDPGLHTSGSDHVKKGLRRVFDSVLDGHGQLSDCALETKVAELLAQGHTKPPECNDADTRNKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPPGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVAFSPQEQELLLTASDDATIKAWRSPRIVRVLQAPRPRPRPRPRPFFSWFASHRR", "length": 573 }, "evidence": [ { "id": "E1B9Q1", "url": "https://omabrowser.org/oma/group/E1B9Q1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VMI1-1", "protein_name": "F-box and WD repeat domain containing 5", "gene_name": "Fbw5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEVTFKKARLGKERLVEQSEEEERDEGSSGQDLFGWWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQEHFKASPSIPLKPGSESWRAEYKRLSMHIPFVQAQRLEPTVENNHGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQHPCSEKYAHNMKQFSWKYSQYSQFNQSDTLLLVSGVHFGSPQSTSGEIAVFYLGATESHLRCRVVNRPYDIFGTWFSDQYLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPIMSQLYKFYNRNASSVRAIMVARCPWLDESNDPLATTADQESHSSVLSPPTGDQGSTSQASGNPVSHAASILRTRSSTPEENYLPDISERRSRARLGDATIHYLDEYRTAVATTNESNDDDDEEYDSMDVQEEYDEMENSIPKYLIFSTGSTTFTPHQIGFKRIRNVFFPKKLDPGPSLKERIAAKRAAEQQQQQTPRTDPDWWDYESVKDRFDKVDKVIDLHGHIIGMALSPDHRYLYVNTRPWPKNYVITNPLEPPPIAQEIDIHVIDLMTLKRVGNMLRAHKAYTPSAECFFIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFKHSDVVNSVAFNPRDSEMLVTTSDDYTIKVWRSRAKAKEFNIPINVSESFELKPKN", "length": 656 }, "evidence": [ { "id": "E1B9Q1", "url": "https://omabrowser.org/oma/group/E1B9Q1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of centrosome duplication", "id": "GO:0010824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010824", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" }, { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" }, { "name": "regulation of cell cycle process", "id": "GO:0010564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010564", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" }, { "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q1" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 49, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B736-1", "uniprot_ac": "E1B736", "uniprot_id": "E1B736_BOVIN", "mass": { "chemical_mass": 130808.0, "monoisotopic_mass": 130808.0 }, "refseq": { "ac": "XP_024845941", "name": "LOW QUALITY PROTEIN: zinc finger SWIM domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845941" }, "gene_names": [ { "name": "ZSWIM5", "type": "recommended", "evidence": [ { "id": "E1B736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B736" } ] }, { "name": "ZSWIM5", "type": "synonym", "evidence": [ { "id": "XP_024845941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845941" } ] } ], "protein_names": [ { "name": "LOW QUALITY PROTEIN: zinc finger SWIM domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "XP_024845941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845941" } ] }, { "name": "Zinc finger SWIM-type containing 5", "type": "synonym", "evidence": [ { "id": "E1B736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B736/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B736", "url": "https://www.uniprot.org/uniprotkb/E1B736" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSWIM5", "url": "https://www.uniprot.org/uniprotkb/E1B736", "locus": { "chromosome": "3", "start_pos": 101031431, "end_pos": 100852581, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012648", "url": "https://www.ensembl.org/id/ENSBTAG00000012648" } ] } } ], "crossref": [ { "id": "E1B736", "url": "https://alphafold.ebi.ac.uk/entry/E1B736", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012648", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012648", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540778", "url": "https://www.ncbi.nlm.nih.gov/gene/540778", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540778", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540778", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR22619", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22619", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22619:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22619:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845941", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845941", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TXD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B736", "url": "https://www.uniprot.org/uniprotkb/E1B736", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B736-1", "url": "https://www.uniprot.org/uniprotkb/E1B736-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGGEREELLSPSPVSPAKRLCSWPSPQAHHPRGSPGAAGGGVGGVGGSCLPPGARPHLQPESLLDCAAKTVAEKWAYERVEERFERIPEPVQRRIVYWSFPRNEREICMYSSFQYRGGPGAGAAGGAAGASPAEEGPPPPPGAAAPAGSAPGAAVAGASPGLGSGAGVAGGGGGEGLPFRRGIRLLDSGSVENVLQVGFHLSGTVTEPATTSEPAVTYKVAISFDRCKITSVTCGCGNKDIFYCAHVVALSLYRIRRPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFLSQGGYYGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFMADPRLTLWRQQGTSMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKWNDLDICPLEDGNYGHELPNITNALPQNASHSSDSLSRPRRTVFTRAIEGRELHWQDSHLQRIISSDIYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIGCLFLTLTEACRLNDDGYLEVSDMNESRPPVYQHVPVAAGCPNSSESYLSLAMEVALMGMGQQRVMPEGLYAQDKVCRNEEQLLSRLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYRLALRAMRLPVLENSTSSGDTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIAAPTDSSTDGTLLNVALELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWACALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHYGEFIEFLSKARETFLLPQDGHLQFAQFIDNLKQIYKGKKKLMLLVRERFG", "length": 1186, "header": "tr|E1B736-1|E1B736_BOVIN Isoform 1 of Zinc finger SWIM-type containing 5 OS=Bos taurus OX=9913 GN=ZSWIM5 PE=4 SV=4 CANONICAL=E1B736-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TXD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXD3/entry", "sequence": { "sequence": "MAEGGEREELLSPSPVSPAKRLCSWPSPQAHHPRGSPGAAGGGVGGVGGSCLPPGARPHLQPESLLDCAAKTVAEKWAYERVEERFERIPEPVQRRIVYWSFPRNEREICMYSSFQYRGGPGAGAAGGAAGASPAEEGPPPPPGAAAPAGSAPGAAVAGASPGLGSGAGVAGGGGGEGLPFRRGIRLLDSGSVENVLQVGFHLSGTVTEPATTSEPAVTYKVAISFDRCKITSVTCGCGNKDIFYCAHVVALSLYRIRRPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFLSQGGYYGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFMADPRLTLWRQQGTSMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKWNDLDICPLEDGNYGHELPNITNALPQNASHSSDSLSRPRRTVFTRAIEGRELHWQDSHLQRIISSDIYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIGCLFLTLTEACRLNDDGYLEVSDMNESRPPVYQHVPVAAGCPNSSESYLSLAMEVALMGMGQQRVMPEGLYAQDKVCRNEEQLLSRLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYRLALRAMRLPVLENSTSSGDTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIAAPTDSSTDGTLLNVALELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWACALSHSLGKNELAAPDPPGGEERALRHSAFRHPSALHGDCSWTGRHPRPPQLRKAHVHRQGSPAPAAGCHHQCLH", "length": 1121, "header": "tr|A0AAA9TXD3-1|E1B736_BOVIN Computationally mapped isoform of Zinc finger SWIM-type containing 5 OS=Bos taurus OX=9913 GN=ZSWIM5 PE=4 SV=1 CANONICAL=E1B736-1" }, "locus": { "chromosome": "3", "start_pos": 101009800, "end_pos": 100852666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136011.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136011.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102110.1" } ] } }, { "isoform_ac": "E1B736-1", "url": "https://www.uniprot.org/uniprotkb/E1B736/entry", "sequence": { "sequence": "MAEGGEREELLSPSPVSPAKRLCSWPSPQAHHPRGSPGAAGGGVGGVGGSCLPPGARPHLQPESLLDCAAKTVAEKWAYERVEERFERIPEPVQRRIVYWSFPRNEREICMYSSFQYRGGPGAGAAGGAAGASPAEEGPPPPPGAAAPAGSAPGAAVAGASPGLGSGAGVAGGGGGEGLPFRRGIRLLDSGSVENVLQVGFHLSGTVTEPATTSEPAVTYKVAISFDRCKITSVTCGCGNKDIFYCAHVVALSLYRIRRPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFLSQGGYYGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFMADPRLTLWRQQGTSMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKWNDLDICPLEDGNYGHELPNITNALPQNASHSSDSLSRPRRTVFTRAIEGRELHWQDSHLQRIISSDIYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIGCLFLTLTEACRLNDDGYLEVSDMNESRPPVYQHVPVAAGCPNSSESYLSLAMEVALMGMGQQRVMPEGLYAQDKVCRNEEQLLSRLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYRLALRAMRLPVLENSTSSGDTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIAAPTDSSTDGTLLNVALELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWACALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHYGEFIEFLSKARETFLLPQDGHLQFAQFIDNLKQIYKGKKKLMLLVRERFG", "length": 1186, "header": "tr|E1B736-1|E1B736_BOVIN Isoform 1 of Zinc finger SWIM-type containing 5 OS=Bos taurus OX=9913 GN=ZSWIM5 PE=4 SV=4 CANONICAL=E1B736-1" }, "locus": { "chromosome": "3", "start_pos": 101031428, "end_pos": 100852666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033299.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033299.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033216.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033216.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 324, "start_aa": "Thr", "end_pos": 324, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr324", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540778", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540778", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B736", "url": "https://www.uniprot.org/uniprotkb/E1B736" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "E1B736", "url": "https://www.uniprot.org/uniprotkb/E1B736" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1122, "end_pos": 1124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 635, "end_pos": 637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B736-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1186, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B736-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B736" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B736" }, { "id": "PS50966", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50966" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SWIM-type", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 257, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 324 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1122, "end_pos": 1124 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 473, "end_pos": 475 }, { "start_pos": 635, "end_pos": 637 }, { "start_pos": 653, "end_pos": 655 }, { "start_pos": 771, "end_pos": 773 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCS4-1", "uniprot_ac": "E1BCS4", "uniprot_id": "E1BCS4_BOVIN", "mass": { "chemical_mass": 22305.0, "monoisotopic_mass": 22305.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM126B", "type": "recommended", "evidence": [ { "id": "E1BCS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCS4" } ] } ], "protein_names": [ { "name": "Transmembrane protein 126B", "type": "synonym", "evidence": [ { "id": "E1BCS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCS4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCS4", "url": "https://www.uniprot.org/uniprotkb/E1BCS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM126B", "url": "https://www.uniprot.org/uniprotkb/E1BCS4", "locus": { "chromosome": "29", "start_pos": 9925062, "end_pos": 9932706, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020596", "url": "https://www.ensembl.org/id/ENSBTAG00000020596" } ] } } ], "crossref": [ { "id": "E1BCS4", "url": "https://alphafold.ebi.ac.uk/entry/E1BCS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020596", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020596", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504229", "url": "https://www.ncbi.nlm.nih.gov/gene/504229", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504229", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504229", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QHYARFE", "url": "https://omabrowser.org/oma/group/QHYARFE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCS4", "url": "https://www.orthodb.org/?gene=E1BCS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16296:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16296:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TZE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCS4", "url": "https://www.uniprot.org/uniprotkb/E1BCS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "IPTYTHGQSRPSLGDAKLSKPVVIEIIEKKIECLRKEKTLNIYGTLTFGTTAAFSGMLTNFIFRHRFKVTHDVLKTYASLTALPFLSTIVSYKLLVTDALCSGNISQENCVLRSSLIGIACGVLYPTALAFSKNGRLAFKYHTVPMPPKGRVLLYWLLLCHTEIKAMVIPLILQTTFGICHGLQHYAIFESTLEKTVHED", "length": 200, "header": "tr|E1BCS4-1|E1BCS4_BOVIN Isoform 1 of Transmembrane protein 126B OS=Bos taurus OX=9913 GN=TMEM126B PE=4 SV=2 CANONICAL=E1BCS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TZE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE6/entry", "sequence": { "sequence": "MAALGREAGDDVRVAGVVPVGAAEVPKDIKIPTYTHGQSRPSLGDAKLSKPVVIEIIEKKIECLRKEKTLNIYGTLTFGTTAAFSGMLTNFIFRHRFKVTHDVLKTYASLTALPFLSTIVSYKLLVTDALCSGNISQENCVLRSSLIGIACGVLYPTALAFSKNGRLAFKYHTVPMPPKGRVLLYWLLLCHTEIKAMVIPLILQTTFGICHGLQHYAIFESTLEKTVHED", "length": 230, "header": "tr|A0AAA9TZE6-1|E1BCS4_BOVIN Computationally mapped isoform of Transmembrane protein 126B OS=Bos taurus OX=9913 GN=TMEM126B PE=4 SV=1 CANONICAL=E1BCS4-1" }, "locus": { "chromosome": "29", "start_pos": 9932507, "end_pos": 9926066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124266.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124266.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102097.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102097.1" } ] } }, { "isoform_ac": "E1BCS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCS4/entry", "sequence": { "sequence": "IPTYTHGQSRPSLGDAKLSKPVVIEIIEKKIECLRKEKTLNIYGTLTFGTTAAFSGMLTNFIFRHRFKVTHDVLKTYASLTALPFLSTIVSYKLLVTDALCSGNISQENCVLRSSLIGIACGVLYPTALAFSKNGRLAFKYHTVPMPPKGRVLLYWLLLCHTEIKAMVIPLILQTTFGICHGLQHYAIFESTLEKTVHED", "length": 200, "header": "tr|E1BCS4-1|E1BCS4_BOVIN Isoform 1 of Transmembrane protein 126B OS=Bos taurus OX=9913 GN=TMEM126B PE=4 SV=2 CANONICAL=E1BCS4-1" }, "locus": { "chromosome": "29", "start_pos": 9929052, "end_pos": 9926066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027441.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027441.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027441.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027441.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504229", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504229", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RZD2-1", "protein_name": "Complex I assembly factor TMEM126B, mitochondrial", "gene_name": "Tmem126b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASERPTGSESGDAGVVLEGNREASQDIKMALYKHGRLIPSLGDAKFGRPMIAEILEKKFESYRNDQTLNIRGTLFFGVSSSLSGVMANLVFRYSFKVKYEALRTYASLTTLPFVATAVTYKLFVTDALQSGNISQESCVLRSSLIGVACGVSYPSALAFYKNGRLAVKYHTVPVPPKGRVMLHWLLLCQTGMKAMAVPLLFQIIFGVFNGLYHYAVCEKAYARIVPDD", "length": 229 }, "evidence": [ { "id": "E1BCS4", "url": "https://omabrowser.org/oma/group/E1BCS4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HXR1-1", "protein_name": "Complex I assembly factor TMEM126B, mitochondrial", "gene_name": "Tmem126b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAASKPQACSEFGDTGVLLKEAREAPQDIKMAIYTYGQLIPSLGDAKFRPMISEIIEKQLEYYKKPTLNIYGTLYFGTTSAMSGLVANIIFRNSFKVQHEALKTCVYLTTLPFLATIITYKLFVTDALHSGNLSKENCIMRSVLIGVGCGILYPSALAFRKNGHLAVKYHSVPLPPKGRVILHWLILSQTGMKLMSAPLVFQAVFGVIHGSHHHALCEKLLGKKCA", "length": 226 }, "evidence": [ { "id": "E1BCS4", "url": "https://omabrowser.org/oma/group/E1BCS4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8IUX1-1", "protein_name": "Complex I assembly factor TMEM126B, mitochondrial", "gene_name": "TMEM126B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVFGYEAGTKPRDSGVVPVGTEEAPKVFKMAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE", "length": 230 }, "evidence": [ { "id": "E1BCS4", "url": "https://omabrowser.org/oma/group/E1BCS4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D1R1-1", "protein_name": "Complex I assembly factor TMEM126B, mitochondrial", "gene_name": "Tmem126b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASQRPSWSESKVAGVVQEGNREAPQDIKMALYKHGQLIPSLGDAKFRSPIISEIIEKKFEHYRNDKTLNIHGTLVFGTSSSLSGIMANLVFRNSFKVKYEALKTYASLTTLPVLATIVSYKLFVTDALQSGDISKESCVLRSALIGMACGVSYPSALAFYKNGRLAVKYQTVPLPPKGRVMLHWLLLCQTGMKAMAIPLFFQIVMGAFTGLHHYNICEKPRARLVPDD", "length": 230 }, "evidence": [ { "id": "E1BCS4", "url": "https://omabrowser.org/oma/group/E1BCS4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "E1BCS4", "url": "https://www.uniprot.org/uniprotkb/E1BCS4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial complex I intermediate assembly complex", "id": "GO:0160295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160295", "evidence": [ { "database": "UniProtKB", "id": "E1BCS4", "url": "https://www.uniprot.org/uniprotkb/E1BCS4" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BCS4", "url": "https://www.uniprot.org/uniprotkb/E1BCS4" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "E1BCS4", "url": "https://www.uniprot.org/uniprotkb/E1BCS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7ASK2-1", "uniprot_ac": "A0AAF7ASK2", "uniprot_id": "A0AAF7ASK2_BOVIN", "mass": { "chemical_mass": 40837.0, "monoisotopic_mass": 40837.0 }, "refseq": {}, "gene_names": [ { "name": "RARRES2", "type": "recommended", "evidence": [ { "id": "A0AAF7ASK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ] } ], "protein_names": [ { "name": "Retinoic acid receptor responder protein 2", "type": "recommended", "evidence": [ { "id": "A0AAF7ASK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2/entry#names_and_taxonomy" } ] }, { "name": "Chemerin", "type": "synonym", "evidence": [ { "id": "A0AAF7ASK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RARRES2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2", "locus": { "chromosome": "4", "start_pos": 112749683, "end_pos": 112753196, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004215", "url": "https://www.ensembl.org/id/ENSBTAG00000004215" } ] } } ], "crossref": [ { "id": "A0AAF7ASK2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7ASK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15106:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15106:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAF6YM65", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ASK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRGIPGGPSAKAGPGGRGGAAGRWRGPRRRWEETGAPPGEPDGCREEAGAAGETPRRSRGGEQERPRGAGEGKGGDLEARERGRGETPRRGGGGEGRPRGGGEECGGSAGRVKGAAPEAGVCWLLREPGPVFEATAWHLCPAGPGSPHLGLSGPREAALGQISRGGSGPQAPPTPVTRIEVRGWRAERGRRLQKRTRQGRKTLPKKTEEGPGDGGEAMWQLLLPLALGLGTMGLGRAELTTAQHRGLQVALEEFHKHPPVLWAFQVTSVDNAADTLFPAGQFVRLEFKLQQTSCRKKDWRKEDCKVKPNGRKRKCLACIKLDSKDQVLGRMVHCPIQTQVQRELDDAQDAQCSRVERAGEDPHSYYLPGQFAFIKALSP", "length": 380, "header": "tr|A0AAF7ASK2-1|A0AAF7ASK2_BOVIN Isoform 1 of Retinoic acid receptor responder protein 2 OS=Bos taurus OX=9913 GN=RARRES2 PE=4 SV=1 CANONICAL=A0AAF7ASK2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM65/entry", "sequence": { "sequence": "ECGGSAGRVKGAAPEAGVCWLLREPGPVFEATAWHLCPAGPGSPHLGLSGPREAALGQISRGGSGPQAPPTPVTRIEVRGWRAERGRRLQKRTRQGRKTLPKKTEELFPAGQFVRLEFKLQQTSCRKKDWRKEDCKVKPNGRKRKCLACIKLDSKDQVLGRMVHCPIQTQVQRELDDAQDAQCSRVERAGEDPHSYYLPGQFAFIKALSP", "length": 210, "header": "tr|A0AAF6YM65-1|A0AAF7ASK2_BOVIN Computationally mapped isoform of Retinoic acid receptor responder protein 2 OS=Bos taurus OX=9913 GN=RARRES2 PE=4 SV=1 CANONICAL=A0AAF7ASK2-1" }, "locus": { "chromosome": "4", "start_pos": 112752827, "end_pos": 112749956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005523.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005523.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005523.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005523.5" } ] } }, { "isoform_ac": "A0AAF7ASK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2/entry", "sequence": { "sequence": "MRRGIPGGPSAKAGPGGRGGAAGRWRGPRRRWEETGAPPGEPDGCREEAGAAGETPRRSRGGEQERPRGAGEGKGGDLEARERGRGETPRRGGGGEGRPRGGGEECGGSAGRVKGAAPEAGVCWLLREPGPVFEATAWHLCPAGPGSPHLGLSGPREAALGQISRGGSGPQAPPTPVTRIEVRGWRAERGRRLQKRTRQGRKTLPKKTEEGPGDGGEAMWQLLLPLALGLGTMGLGRAELTTAQHRGLQVALEEFHKHPPVLWAFQVTSVDNAADTLFPAGQFVRLEFKLQQTSCRKKDWRKEDCKVKPNGRKRKCLACIKLDSKDQVLGRMVHCPIQTQVQRELDDAQDAQCSRVERAGEDPHSYYLPGQFAFIKALSP", "length": 380, "header": "tr|A0AAF7ASK2-1|A0AAF7ASK2_BOVIN Isoform 1 of Retinoic acid receptor responder protein 2 OS=Bos taurus OX=9913 GN=RARRES2 PE=4 SV=1 CANONICAL=A0AAF7ASK2-1" }, "locus": { "chromosome": "4", "start_pos": 112753139, "end_pos": 112749956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084323.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084323.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074117.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074117.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 175, "start_aa": "Thr", "end_pos": 175, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" }, { "name": "regulation of lipid catabolic process", "id": "GO:0050994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050994", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" }, { "name": "positive regulation of chemotaxis", "id": "GO:0050921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050921", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ASK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ASK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 175 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AKB2-1", "uniprot_ac": "A0AAF7AKB2", "uniprot_id": "A0AAF7AKB2_BOVIN", "mass": { "chemical_mass": 62373.0, "monoisotopic_mass": 62373.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM184A", "type": "recommended", "evidence": [ { "id": "A0AAF7AKB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2" } ] } ], "protein_names": [ { "name": "Transmembrane protein 184A", "type": "synonym", "evidence": [ { "id": "A0AAF7AKB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AKB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM184A", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2", "locus": { "chromosome": "25", "start_pos": 41402061, "end_pos": 41394782, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004676", "url": "https://www.ensembl.org/id/ENSBTAG00000004676" } ] } } ], "crossref": [ { "id": "A0AAF7AKB2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AKB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YMX1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AKB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AKB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRQAGWVGGYRARPPPRPLLRAGPVWLASQTPPPAGRATGTPRLPLMSLAPGRRLPEAQDTRGGIAPGHGRAAGVCAQAADTRKESTSGPGLGVGSLHTEGCPEPRHAGRRICLAPLWEGRWPKPSLAAQPGAAARPHAARPQRTFALSTPHVPFLPLQMTDTPGLLGTPLAWTPPARPAGPQMERAGNGSQGPGPLFLTSPLARGVSGVFVWAALVLTGHQIYLHLRSYTVPHEQRYIIRLLFIVPVYAFDSWLSLLLLGGHQHYIYFDSVRDCYEAFVIYSFLSLCFQYLGGESAIMAEIRGKPVRTSCFHGTCCLRGMTYSIGFLRFCKQATLQFCIVKPIMALVTIVLQAFGKYHDGDFNVRSGYLYITLVYNASVSLALYALFLFYSATRELLQPFEPVLKFLTIKAVIFLSFWQGLLLAILERCGVIPEVQVIDGSTVGAGTVAAGYQNFIICIEMLFASIALRYAFTCQVYSEKTESSPAPSAPMQSISSGLKETMSPQDIVQDAIHNFSPAYQKYTQQATQEAPRPGQGSVPSPRTPTHSPDGGPGGGRKGRNVEKRMLIPAEEL", "length": 574, "header": "tr|A0AAF7AKB2-1|A0AAF7AKB2_BOVIN Isoform 1 of Transmembrane protein 184A OS=Bos taurus OX=9913 GN=TMEM184A PE=4 SV=1 CANONICAL=A0AAF7AKB2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YMX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX1/entry", "sequence": { "sequence": "MGEQSWGGQEPWPSRTPDGQMTDTPGLLGTPLAWTPPARPAGPQMERAGNGSQGPGPLFLTSPLARGVSGVFVWAALVLTGHQIYLHLRSYTVPHEQRYIIRLLFIVPVYAFDSWLSLLLLGGHQHYIYFDSVRDCYEAFVIYSFLSLCFQYLGGESAIMAEIRGKPVRTSCFHGTCCLRGMTYSIGFLRFCKQATLQFCIVKPIMALVTIVLQAFGKYHDGDFNVRSGYLYITLVYNASVSLALYALFLFYSATRELLQPFEPVLKFLTIKAVIFLSFWQGLLLAILERCGVIPEVQVIDGSTVGAGTVAAGYQNFIICIEMLFASIALRYAFTCQVYSEKTESSPAPSAPMQSISSGLKETMSPQDIVQDAIHNFSPAYQKYTQQATQEAPRPGQGSVPSPRTPTHSPDGGPGGGRKGRNVEKRMLIPAEEL", "length": 434, "header": "tr|A0AAF6YMX1-1|A0AAF7AKB2_BOVIN Computationally mapped isoform of Transmembrane protein 184A OS=Bos taurus OX=9913 GN=TMEM184A PE=4 SV=1 CANONICAL=A0AAF7AKB2-1" }, "locus": { "chromosome": "25", "start_pos": 41401549, "end_pos": 41394929, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006135.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006135.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006135.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006135.5" } ] } }, { "isoform_ac": "A0AAF7AKB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2/entry", "sequence": { "sequence": "MVRQAGWVGGYRARPPPRPLLRAGPVWLASQTPPPAGRATGTPRLPLMSLAPGRRLPEAQDTRGGIAPGHGRAAGVCAQAADTRKESTSGPGLGVGSLHTEGCPEPRHAGRRICLAPLWEGRWPKPSLAAQPGAAARPHAARPQRTFALSTPHVPFLPLQMTDTPGLLGTPLAWTPPARPAGPQMERAGNGSQGPGPLFLTSPLARGVSGVFVWAALVLTGHQIYLHLRSYTVPHEQRYIIRLLFIVPVYAFDSWLSLLLLGGHQHYIYFDSVRDCYEAFVIYSFLSLCFQYLGGESAIMAEIRGKPVRTSCFHGTCCLRGMTYSIGFLRFCKQATLQFCIVKPIMALVTIVLQAFGKYHDGDFNVRSGYLYITLVYNASVSLALYALFLFYSATRELLQPFEPVLKFLTIKAVIFLSFWQGLLLAILERCGVIPEVQVIDGSTVGAGTVAAGYQNFIICIEMLFASIALRYAFTCQVYSEKTESSPAPSAPMQSISSGLKETMSPQDIVQDAIHNFSPAYQKYTQQATQEAPRPGQGSVPSPRTPTHSPDGGPGGGRKGRNVEKRMLIPAEEL", "length": 574, "header": "tr|A0AAF7AKB2-1|A0AAF7AKB2_BOVIN Isoform 1 of Transmembrane protein 184A OS=Bos taurus OX=9913 GN=TMEM184A PE=4 SV=1 CANONICAL=A0AAF7AKB2-1" }, "locus": { "chromosome": "25", "start_pos": 41401549, "end_pos": 41394981, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070260.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070260.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070248.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070248.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AKB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AKB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 516, "end_pos": 518 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AP20-1", "uniprot_ac": "A0AAF7AP20", "uniprot_id": "A0AAF7AP20_BOVIN", "mass": { "chemical_mass": 52785.0, "monoisotopic_mass": 52785.0 }, "refseq": {}, "gene_names": [ { "name": "ETS2", "type": "recommended", "evidence": [ { "id": "A0AAF7AP20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ] } ], "protein_names": [ { "name": "Protein C-ets-2", "type": "recommended", "evidence": [ { "id": "A0AAF7AP20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcription factor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20#function" }, { "database": "UniProtKB", "id": "PIRNR001698", "url": "https://www.uniprot.org/uniprotkb/PIRNR001698#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETS2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20", "locus": { "chromosome": "1", "start_pos": 151181631, "end_pos": 151158747, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009214", "url": "https://www.ensembl.org/id/ENSBTAG00000009214" } ] } } ], "crossref": [ { "id": "A0AAF7AP20", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AP20", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08543", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08543", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016311", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016311", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045688", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045688", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YT65", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YT65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AP20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYP1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYP1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMNDFGIKNMDQVAPVASSYRGTLKRQAAFDTFDGSLLAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVDVNLQRFGMTGQVLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKNEDQYEENSHLNSVPHWINSNSLGFGVEQAPYGMQTQSYPKGGLLDGLCPASSAPSTLGPEQDFQMFPKARLNTVSVNYCSVGQDFPAGSLNLLSSASGKPRDHDSAETGGDSFESSESLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLGLSKPTMSFKDYIQDRSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED", "length": 471, "header": "tr|A0AAF7AP20-1|A0AAF7AP20_BOVIN Isoform 1 of Protein C-ets-2 OS=Bos taurus OX=9913 GN=ETS2 PE=3 SV=1 CANONICAL=A0AAF7AP20-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YT65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT65/entry", "sequence": { "sequence": "MDGSRFQISHLQPLKAFGEKPHNFVCCQKYSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVDVNLQRFGMTGQVLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKNEDQYEENSHLNSVPHWINSNSLGFGVEQAPYGMQTQSYPKGGLLDGLCPASSAPSTLGPEQDFQMFPKARLNTVSVNYCSVGQDFPAGSLNLLSSASGKPRDHDSAETGGDSFESSESLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLGLSKPTMSFKDYIQDRSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED", "length": 438, "header": "tr|A0AAF6YT65-1|A0AAF7AP20_BOVIN Computationally mapped isoform of Protein C-ets-2 OS=Bos taurus OX=9913 GN=ETS2 PE=3 SV=1 CANONICAL=A0AAF7AP20-1" }, "locus": { "chromosome": "1", "start_pos": 151179626, "end_pos": 151170869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012144.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012144.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012144.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012144.6" } ] } }, { "isoform_ac": "A0AAF7AP20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20/entry", "sequence": { "sequence": "MMNDFGIKNMDQVAPVASSYRGTLKRQAAFDTFDGSLLAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVDVNLQRFGMTGQVLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKNEDQYEENSHLNSVPHWINSNSLGFGVEQAPYGMQTQSYPKGGLLDGLCPASSAPSTLGPEQDFQMFPKARLNTVSVNYCSVGQDFPAGSLNLLSSASGKPRDHDSAETGGDSFESSESLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLGLSKPTMSFKDYIQDRSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED", "length": 471, "header": "tr|A0AAF7AP20-1|A0AAF7AP20_BOVIN Isoform 1 of Protein C-ets-2 OS=Bos taurus OX=9913 GN=ETS2 PE=3 SV=1 CANONICAL=A0AAF7AP20-1" }, "locus": { "chromosome": "1", "start_pos": 151179626, "end_pos": 151160457, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074510.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074510.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072496.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072496.2" } ] } }, { "isoform_ac": "A0ABI0NYP1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYP1/entry", "sequence": { "sequence": "MMRQAAFDTFDGSLLAVFPSLNEEQTLQEVPTGLDSISHDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVDVNLQRFGMTGQVLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKNEDQYEENSHLNSVPHWINSNSLGFGVEQAPYGMQTQSYPKGGLLDGLCPASSAPSTLGPEQDFQMFPKARLNTVSVNYCSVGQDFPAGSLNLLSSASGKPRDHDSAETGGDSFESSESLLQSWNSQSSLLDVQRVPSFESFEDDCSQSLGLSKPTMSFKDYIQDRSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED", "length": 448, "header": "tr|A0ABI0NYP1-1|A0ABI0NYP1_BOVIN Computationally mapped isoform of ETS proto-onco 2, transcription factor OS=Bos taurus OX=9913 GN=ETS2 PE=3 SV=1 CANONICAL=A0AAF7AP20-1" }, "locus": { "chromosome": "1", "start_pos": 151179626, "end_pos": 151169564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136928.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136928.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107443.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AP20", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AP20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 365, "end_pos": 445, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0AAF7AP20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AP20" }, { "id": "PS51433", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51433" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PNT", "eco_id": "ECO_0000259", "start_pos": 86, "end_pos": 171, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AI76-1", "uniprot_ac": "A0AAF7AI76", "uniprot_id": "A0AAF7AI76_BOVIN", "mass": { "chemical_mass": 62588.0, "monoisotopic_mass": 62588.0 }, "refseq": {}, "gene_names": [ { "name": "ALDH3B1", "type": "recommended", "evidence": [ { "id": "A0AAF7AI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76" } ] } ], "protein_names": [ { "name": "aldehyde dehydrogenase [NAD(P)(+)]", "type": "recommended", "evidence": [ { "id": "A0AAF7AI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76/entry#names_and_taxonomy" } ] }, { "name": "1.2.1.5", "type": "synonym", "evidence": [ { "id": "A0AAF7AI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AI76", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALDH3B1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76", "locus": { "chromosome": "29", "start_pos": 45557679, "end_pos": 45541832, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013093", "url": "https://www.ensembl.org/id/ENSBTAG00000013093" } ] } } ], "crossref": [ { "id": "A0AAF7AI76", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AI76", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07132", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07132", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR012394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029510", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029510", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43570", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43570", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43570:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43570:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF6YWT9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYK3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZF27", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZF27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZF27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZF27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AI76", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AI76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERGVWWATVHENHKESDMTEQLTHMQCGGEHSRGPTVRTYKGVIMVGCLKEASAKQRPERRESEEKEERVPTGPWQQAEDRVRQSTPLVSFRMDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKSAFEAEVSEISISQNEINLALRNLRTWMKDEKVSKNLATQLDSAFIRKEPFGLVLILSPWNYPLNLSLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSCFAVVLGGPQETGRLLEHKFDYIFFTGNPQVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAFFRCFNAGQTCVAPDYVLCSPEMQAQLVPALQSAITRFYGDDPQSSPNLGRIISQKHFQRLRGLLSCGRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREKPLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVGSSGMGNYHGKFSFDTFSHHRACLLRRPGLEKIYAIRYPPHTPRNLRVLLMAMETRSCSCTLL", "length": 561, "header": "tr|A0AAF7AI76-1|A0AAF7AI76_BOVIN Isoform 1 of aldehyde dehydrogenase [NAD(P)(+)] OS=Bos taurus OX=9913 GN=ALDH3B1 PE=3 SV=1 CANONICAL=A0AAF7AI76-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YWT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWT9/entry", "sequence": { "sequence": "MDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKATQLDSAFIRKEPFGLVLILSPWNYPLNLSLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSCFAVVLGGPQETGRLLEHKFDYIFFTGNPQVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAFFRCFNAGQTCVAPDYVLCSPEMQAQLVPALQSAITRFYGDDPQSSPNLGRIISQKHFQRLRGLLSCGRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREKPLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVGSSGMGNYHGKFSFDTFSHHRACLLRRPGLEKIYAIRYPPHTPRNLRVLLMAMETRSCSCTLL", "length": 431, "header": "tr|A0AAF6YWT9-1|A0AAF7AI76_BOVIN Computationally mapped isoform of aldehyde dehydrogenase [NAD(P)(+)] OS=Bos taurus OX=9913 GN=ALDH3B1 PE=3 SV=1 CANONICAL=A0AAF7AI76-1" }, "locus": { "chromosome": "29", "start_pos": 45556990, "end_pos": 45543094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015995.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015995.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015995.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015995.7" } ] } }, { "isoform_ac": "A0AAF6YYK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYK3/entry", "sequence": { "sequence": "MDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKSAFEAEVSEISISQNEINLALRNLRTWMKDEKVSKNLATQLDSAFIRKEPFGLVLILSPWNYPLNLSLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSCFAVVLGGPQETGRLLEHKFDYIFFTGNPQVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAFFRCFNAGQTCVAPDYVLCSPEMQAQLVPALQSAITRFYGDDPQSSPNLGRIISQKHFQRLRGLLSCGRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREKPLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVAAGWAITTASSPSTPSPTTAPACCAAPGWRRSTPSATRPTLRAT", "length": 449, "header": "tr|A0AAF6YYK3-1|A0AAF7AI76_BOVIN Computationally mapped isoform of aldehyde dehydrogenase [NAD(P)(+)] OS=Bos taurus OX=9913 GN=ALDH3B1 PE=3 SV=1 CANONICAL=A0AAF7AI76-1" }, "locus": { "chromosome": "29", "start_pos": 45556937, "end_pos": 45543094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017408.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017408.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017408.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017408.6" } ] } }, { "isoform_ac": "A0AAF6ZF27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZF27/entry", "sequence": { "sequence": "MDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKSAFEAEVSEISISQNEINLALRNLRTWMKDEKVSKNLATQLDSAFIRKEPFGLVLILSPWNYPLNLSLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSSPNLGRIISQKHFQRLRGLLSCGRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREKPLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVGSSGMGNYHGKFSFDTFSHHRACLLRRPGLEKIYAIRYPPHTPRNLRVLLMAMETRSCSCTLL", "length": 351, "header": "tr|A0AAF6ZF27-1|A0AAF7AI76_BOVIN Computationally mapped isoform of aldehyde dehydrogenase [NAD(P)(+)] OS=Bos taurus OX=9913 GN=ALDH3B1 PE=3 SV=1 CANONICAL=A0AAF7AI76-1" }, "locus": { "chromosome": "29", "start_pos": 45556990, "end_pos": 45543094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044598.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044598.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042081.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042081.4" } ] } }, { "isoform_ac": "A0AAF7AI76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76/entry", "sequence": { "sequence": "MERGVWWATVHENHKESDMTEQLTHMQCGGEHSRGPTVRTYKGVIMVGCLKEASAKQRPERRESEEKEERVPTGPWQQAEDRVRQSTPLVSFRMDPFADTLQRLREAFVSGRTRPAEFRDAQLKGLSRFLRENKQLLQEALAQDLHKSAFEAEVSEISISQNEINLALRNLRTWMKDEKVSKNLATQLDSAFIRKEPFGLVLILSPWNYPLNLSLGPLVGALAAGNCVVLKPSEISKNTEKVLAEVLPRYLDQSCFAVVLGGPQETGRLLEHKFDYIFFTGNPQVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAFFRCFNAGQTCVAPDYVLCSPEMQAQLVPALQSAITRFYGDDPQSSPNLGRIISQKHFQRLRGLLSCGRVVIGGQSDECDLYIAPTVLVDVQETDPVMQEEIFGPILPIVNVRSLGQAIDFINRREKPLALYAFSNSSQVVKRVLAQTSSGGFCGNDGFMHLTLASLPFGGVGSSGMGNYHGKFSFDTFSHHRACLLRRPGLEKIYAIRYPPHTPRNLRVLLMAMETRSCSCTLL", "length": 561, "header": "tr|A0AAF7AI76-1|A0AAF7AI76_BOVIN Isoform 1 of aldehyde dehydrogenase [NAD(P)(+)] OS=Bos taurus OX=9913 GN=ALDH3B1 PE=3 SV=1 CANONICAL=A0AAF7AI76-1" }, "locus": { "chromosome": "29", "start_pos": 45556990, "end_pos": 45542010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076578.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076578.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069355.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069355.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "aldehyde metabolic process", "id": "GO:0006081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006081", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AI76", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "id": "GO:0016620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016620", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AI76", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76" } ], "pmid": "" }, { "name": "aldehyde dehydrogenase [NAD(P)+] activity", "id": "GO:0004030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004030", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AI76", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AI76" }, { "id": "PF00171", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aldehyde dehydrogenase", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 517, "start_aa": "Arg", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.2.1.5", "ec_name": "an aldehyde + NADP(+) + H2O = a carboxylate + NADPH + 2 H(+).", "evidence": [ { "id": "1.2.1.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5" }, { "id": "1.2.1.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 462, "end_pos": 464 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AQ05-1", "uniprot_ac": "A0AAF7AQ05", "uniprot_id": "A0AAF7AQ05_BOVIN", "mass": { "chemical_mass": 19057.0, "monoisotopic_mass": 19057.0 }, "refseq": {}, "gene_names": [ { "name": "RPL27A", "type": "recommended", "evidence": [ { "id": "A0AAF7AQ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL15", "type": "recommended", "evidence": [ { "id": "A0AAF7AQ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L27a", "type": "synonym", "evidence": [ { "id": "A0AAF7AQ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AQ05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL27A", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05", "locus": {} } ], "crossref": [ { "id": "A0AAF7AQ05", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AQ05", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11721", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11721", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11721:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11721:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00828", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00828", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF7AQ05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AQ05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGFFTTVPPGNPIHGLDSRNQLSELKDPCA", "length": 170, "header": "tr|A0AAF7AQ05-1|A0AAF7AQ05_BOVIN Isoform 1 of Large ribosomal subunit protein uL15 OS=Bos taurus OX=9913 GN=RPL27A PE=3 SV=1 CANONICAL=A0AAF7AQ05-1" }, "isoforms": [ { "isoform_ac": "A0AAF7AQ05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05/entry", "sequence": { "sequence": "MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGFFTTVPPGNPIHGLDSRNQLSELKDPCA", "length": 170, "header": "tr|A0AAF7AQ05-1|A0AAF7AQ05_BOVIN Isoform 1 of Large ribosomal subunit protein uL15 OS=Bos taurus OX=9913 GN=RPL27A PE=3 SV=1 CANONICAL=A0AAF7AQ05-1" }, "locus": { "chromosome": "15", "start_pos": 43882613, "end_pos": 43879199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066379.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066379.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072774.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072774.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AQ05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AQ05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AQ05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AQ05", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AQ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AQ05" }, { "id": "PF00828", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00828" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL15/eL18", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 142, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 66, "end_pos": 68 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0JNL1-1", "uniprot_ac": "A0JNL1", "uniprot_id": "CG057_BOVIN", "mass": { "chemical_mass": 31729.0, "monoisotopic_mass": 31729.0 }, "refseq": { "ac": "NP_001073253", "name": "uncharacterized protein C7orf57 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073253" }, "gene_names": [ { "name": "C4H7orf57", "type": "synonym", "evidence": [ { "id": "NP_001073253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073253" } ] }, { "name": "C7orf57", "type": "synonym", "evidence": [ { "id": "NP_001073253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073253" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C7orf57 homolog", "type": "recommended", "evidence": [ { "id": "A0JNL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNL1/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C7orf57 homolog", "type": "synonym", "evidence": [ { "id": "NP_001073253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073253" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0JNL1", "url": "https://www.uniprot.org/uniprotkb/A0JNL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0JNL1", "locus": {} } ], "crossref": [ { "id": "A0JNL1", "url": "https://alphafold.ebi.ac.uk/entry/A0JNL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614195", "url": "https://www.ncbi.nlm.nih.gov/gene/614195", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614195", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614195", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MVYEEFH", "url": "https://omabrowser.org/oma/group/MVYEEFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0JNL1", "url": "https://www.orthodb.org/?gene=A0JNL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31097:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31097:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073253", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0JNL1", "url": "https://www.uniprot.org/uniprotkb/A0JNL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JNL1-1", "url": "https://www.uniprot.org/uniprotkb/A0JNL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNTSKELHGAASRYAPCDWYYHLPVKQSEKAVDAPPASQIPGLSDPREAPSGHTLGLRRYWVKETDSEYVKLAKQGGRPDLLKHFAPGTTKGSPVAYSLPDWYIHHSKPPTADQRQVPAVSIPDYMVYEEFNPDQATGNFESRMGPFDFDMKTIWQREAEELEKEKKKVRLPAIKSKYPSKVGTPLGHREPAGSKLSFPPIPGQRPSSPTNFSKLISNGYKDEWLQQQADSDKRAPQTPQSSVSSPSPLDAELPADPEAPGDTTEAAESSPLSSAAPPPDSTPVELK", "length": 288, "header": "sp|A0JNL1-1|CG057_BOVIN Isoform 1 of Uncharacterized protein C7orf57 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A0JNL1-1" }, "isoforms": [ { "isoform_ac": "A0JNL1-1", "url": "https://www.uniprot.org/uniprotkb/A0JNL1/entry#A0JNL1-1", "sequence": { "sequence": "MRNTSKELHGAASRYAPCDWYYHLPVKQSEKAVDAPPASQIPGLSDPREAPSGHTLGLRRYWVKETDSEYVKLAKQGGRPDLLKHFAPGTTKGSPVAYSLPDWYIHHSKPPTADQRQVPAVSIPDYMVYEEFNPDQATGNFESRMGPFDFDMKTIWQREAEELEKEKKKVRLPAIKSKYPSKVGTPLGHREPAGSKLSFPPIPGQRPSSPTNFSKLISNGYKDEWLQQQADSDKRAPQTPQSSVSSPSPLDAELPADPEAPGDTTEAAESSPLSSAAPPPDSTPVELK", "length": 288, "header": "sp|A0JNL1-1|CG057_BOVIN Isoform 1 of Uncharacterized protein C7orf57 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A0JNL1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614195", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614195", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B5F3-1", "protein_name": "Chromosome 18 C7orf57 homolog", "gene_name": "C18H7orf57", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNTSKELHGATSRYAPCDWYYHHPVKRSEKAVDAPPASQIPGLSNLRAPHNGHILGPRRYWVKETDSEYVKLAKQGGRPDLLKHFAPGTRTGSPVAYSLPDWYIHHSKPPTADQRQVPAVSIPDYMVYEEFSPDQSSGNYEFRRGPFDFDMKTVWQREAEELEKEKKKVRLPAIKPKYPSKVGTPLGPKDPAGSKLSFPPMPGQKTSSPTNFSKLISNGYKDEWLQQQADSAKGSPPPPTRASASPASPKDAQQPPDPEAPQGGAKEGQESSPPSPAASPSTSAPAGLK", "length": 290 }, "evidence": [ { "id": "A0JNL1", "url": "https://omabrowser.org/oma/group/A0JNL1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0JPQ1-1", "protein_name": "Uncharacterized protein C7orf57 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNTSKEVQSTSYRYAPCDWYYHLPVKRSEKPVGAPPASQIPGLSDLRDSPSVNLPRARRYWIKETDSEYVKLAKQGGRPDLLKHFAPGTRQGSPVAYSLPDWYIHHSKPPTSLQREVPAVSIPEYMVYEEFNPDQANGSYESRQGPFDFDRKTIWQREAEELENVKRKVKLPAINSKNSSKAGTPVNNKDSDKSRLSLPPMPGPKTGSPTNFSKLISNGYKDEWLQQQKADSDRRTPKTSEASVSTQSTEDSKSKSSQDTETPQNSETPEGSEKTPDAEAPPSEATPEELK", "length": 292 }, "evidence": [ { "id": "A0JNL1", "url": "https://omabrowser.org/oma/group/A0JNL1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SS90-1", "protein_name": "Uncharacterized protein C7orf57 homolog", "gene_name": "Gm11992", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRNTSKEVQSTSYRYAPCDWYYHLPVKRSEKPVGAPPASQIPGLSDLRDSPNVNLPRARRYWIKETDSEYVKLAKQGGRPDLLKHFAPGTRQGSPVAYSLPDWYIHHSKPPTSHQREVPVVSIPDYMVYEEFNPDQANGSYESRQGPFDFDRKTIWQREAEELENVKRKVKLPAINSKNPSKTGTPVSHKEPERSRLSLPPMPGQKNSSPTNFSKLISNGYKDEWLQQQKAEADRRTPKTSRASVSSKSTEDSKSNQDTETPENPETPEGSEKTPDAEVSSPSESTPAELK", "length": 291 }, "evidence": [ { "id": "A0JNL1", "url": "https://omabrowser.org/oma/group/A0JNL1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NEG2-1", "protein_name": "Uncharacterized protein C7orf57", "gene_name": "C7orf57", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRNTSKELQGATHRYAPCDWYYHVPVKRSEKAVDAPPASQIPGLSNLGDSHSENLPGTRRYWIKETDSEYVKLAKQGGRPDLLKHFAPGTRKGSPVAYSLPDWYIHHSKPPTASQQEVRAVSMPDYMVHEEFNPDQANGSYASRRGPFDFDMKTVWQREAEELEKEKKKLRLPAIDSKYLSKAGTPLGPKNPAGSRLSFPPVPGQKNSSPTNFSKLISNGYKDEWLQQQQRADSDKRTPKTSRASVLSQSPRDLEGPQDAARLQDAEASEGPEDTPESSQSPEESVSASTPAELK", "length": 295 }, "evidence": [ { "id": "A0JNL1", "url": "https://omabrowser.org/oma/group/A0JNL1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0JNL1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 288, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0JNL1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0JNL1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A1A4Q2-1", "uniprot_ac": "A1A4Q2", "uniprot_id": "PRXD1_BOVIN", "mass": { "chemical_mass": 18972.0, "monoisotopic_mass": 18972.0 }, "refseq": { "ac": "NP_001073758", "name": "prolyl-tRNA synthetase associated domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073758" }, "gene_names": [ { "name": "PRORSD1", "type": "recommended", "evidence": [ { "id": "A1A4Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2" } ] }, { "name": "PRDXDD1", "type": "synonym", "evidence": [ { "id": "NP_001073758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073758" }, { "id": "A1A4Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2" } ] }, { "name": "PRORSD1", "type": "synonym", "evidence": [ { "id": "NP_001073758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073758" } ] } ], "protein_names": [ { "name": "Prolyl-tRNA synthetase associated domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A1A4Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2/entry#names_and_taxonomy" } ] }, { "name": "PrdX deacylase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A1A4Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2/entry#names_and_taxonomy" } ] }, { "name": "prolyl-tRNA synthetase associated domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001073758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073758" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A1A4Q2", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRORSD1", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2", "locus": {} } ], "crossref": [ { "id": "A1A4Q2", "url": "https://alphafold.ebi.ac.uk/entry/A1A4Q2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04335", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04335", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526913", "url": "https://www.ncbi.nlm.nih.gov/gene/526913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526913", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526913", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A1A4Q2", "url": "https://www.orthodb.org/?gene=A1A4Q2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31423:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31423:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073758", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A1A4Q2", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1A4Q2-1", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAELRAALEQRLAALAIRTEVVEHPEVFTVEEMMPHIQHLKGAHSKNLFLKDKKKKGYWLVTVLHDRQINLNDLAKQLGVGSGNLRFADEAAMLEKLKVGQGCATPLALFCDDGDVKFVLDSAFLEGGHEKVYFHPMTNAATMGLSPEDFLTFVKNTGHDPIILNFDKN", "length": 171, "header": "sp|A1A4Q2-1|PRXD1_BOVIN Isoform 1 of Prolyl-tRNA synthetase associated domain-containing protein 1 OS=Bos taurus OX=9913 GN=PRORSD1 PE=2 SV=1 CANONICAL=A1A4Q2-1" }, "isoforms": [ { "isoform_ac": "A1A4Q2-1", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2/entry#A1A4Q2-1", "sequence": { "sequence": "MAGAELRAALEQRLAALAIRTEVVEHPEVFTVEEMMPHIQHLKGAHSKNLFLKDKKKKGYWLVTVLHDRQINLNDLAKQLGVGSGNLRFADEAAMLEKLKVGQGCATPLALFCDDGDVKFVLDSAFLEGGHEKVYFHPMTNAATMGLSPEDFLTFVKNTGHDPIILNFDKN", "length": 171, "header": "sp|A1A4Q2-1|PRXD1_BOVIN Isoform 1 of Prolyl-tRNA synthetase associated domain-containing protein 1 OS=Bos taurus OX=9913 GN=PRORSD1 PE=2 SV=1 CANONICAL=A1A4Q2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526913", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526913", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "aminoacyl-tRNA metabolism involved in translational fidelity", "id": "GO:0106074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106074", "evidence": [ { "database": "UniProtKB", "id": "A1A4Q2", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "Ser-tRNA(Ala) deacylase activity", "id": "GO:0002196", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002196", "evidence": [ { "database": "UniProtKB", "id": "A1A4Q2", "url": "https://www.uniprot.org/uniprotkb/A1A4Q2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A1A4Q2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 171, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A1A4Q2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A1A4Q2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A4FUB7-1", "uniprot_ac": "A4FUB7", "uniprot_id": "GIN1_BOVIN", "mass": { "chemical_mass": 56939.0, "monoisotopic_mass": 56939.0 }, "refseq": { "ac": "NP_001019644", "name": "gypsy retrotransposon integrase-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019644" }, "gene_names": [ { "name": "GIN1", "type": "recommended", "evidence": [ { "id": "A4FUB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUB7" } ] }, { "name": "GIN1", "type": "synonym", "evidence": [ { "id": "NP_001019644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019644" } ] } ], "protein_names": [ { "name": "Gypsy retrotransposon integrase-like protein 1", "type": "recommended", "evidence": [ { "id": "A4FUB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUB7/entry#names_and_taxonomy" } ] }, { "name": "GIN-1", "type": "synonym", "evidence": [ { "id": "NP_001019644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019644" }, { "id": "A4FUB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUB7/entry#names_and_taxonomy" } ] }, { "name": "gypsy retrotransposon integrase-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001019644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019644" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A4FUB7", "url": "https://www.uniprot.org/uniprotkb/A4FUB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIN1", "url": "https://www.uniprot.org/uniprotkb/A4FUB7", "locus": { "chromosome": "7", "start_pos": 102111763, "end_pos": 102142033, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021471", "url": "https://www.ensembl.org/id/ENSBTAG00000021471" } ] } } ], "crossref": [ { "id": "A4FUB7", "url": "https://alphafold.ebi.ac.uk/entry/A4FUB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021471", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021471", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504972", "url": "https://www.ncbi.nlm.nih.gov/gene/504972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504972", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504972", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPNNWDD", "url": "https://omabrowser.org/oma/group/YPNNWDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A4FUB7", "url": "https://www.orthodb.org/?gene=A4FUB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37984:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37984:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00665", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00665", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019644", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A4FUB7", "url": "https://www.uniprot.org/uniprotkb/A4FUB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4FUB7-1", "url": "https://www.uniprot.org/uniprotkb/A4FUB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQINVELCELFGTKQIVISHASQTINPAESTPSTIKTFLSKHCVDYPNDWDDHLPAVSFAFNVTHLEPTKNTPYFQMFNRNPYMPESSDIREVDGDNTSMFAKILDAIKEADKIMENKTTSVGQMENNNCHELNKSKIIVKKKPKQQNPFHLKVGHEVLRQRKNWWKDGRFRSEWVGPCVIDYITENGGAVLRDSSGARLKRPIKMSHLKPYVRESGEQDSLHLLHGSVVADHDYVGMPELPVGAYQASILVEDAAIGVDDSELLTSSKDRELLEYRNAKISPLMEDHNALEKQTFSLLDSSNQVLEYLT", "length": 499, "header": "sp|A4FUB7-1|GIN1_BOVIN Isoform 1 of Gypsy retrotransposon integrase-like protein 1 OS=Bos taurus OX=9913 GN=GIN1 PE=2 SV=1 CANONICAL=A4FUB7-1" }, "isoforms": [ { "isoform_ac": "A4FUB7-1", "url": "https://www.uniprot.org/uniprotkb/A4FUB7/entry#A4FUB7-1", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVVILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIHQINVELCELFGTKQIVISHASQTINPAESTPSTIKTFLSKHCVDYPNDWDDHLPAVSFAFNVTHLEPTKNTPYFQMFNRNPYMPESSDIREVDGDNTSMFAKILDAIKEADKIMENKTTSVGQMENNNCHELNKSKIIVKKKPKQQNPFHLKVGHEVLRQRKNWWKDGRFRSEWVGPCVIDYITENGGAVLRDSSGARLKRPIKMSHLKPYVRESGEQDSLHLLHGSVVADHDYVGMPELPVGAYQASILVEDAAIGVDDSELLTSSKDRELLEYRNAKISPLMEDHNALEKQTFSLLDSSNQVLEYLT", "length": 499, "header": "sp|A4FUB7-1|GIN1_BOVIN Isoform 1 of Gypsy retrotransposon integrase-like protein 1 OS=Bos taurus OX=9913 GN=GIN1 PE=2 SV=1 CANONICAL=A4FUB7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 220, "start_aa": "Thr", "end_pos": 220, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr220", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504972", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504972", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y6T4-1", "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "GIN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVRSGKNGGLHLKQIAYYKRTGEYHPTTLSSERSGIRRAAKKFVFKENKLFYVGKDRKQMRLVIVSDEEKKNVLQKCHENAAGTHHGISRTLTLVESNYYWTSVTNDVKQWVYACQHCQVAKSTTTTTLKPYPIKAEDPWTAVTVALMGPFRATKRSHKYVIIMIDLFTKWTVILPLHDTSAAEIAKAIISVFFLYGPPQKMPIDQGKELVHQSCFLWINKELFALFGMKQIVLSYPQTNEVSERTCKTVKAFLNKYCTDHPNDWDEHLSAIAYAFNLTNLEPDRNTPYFQMFNRNPYVEPMNIRVEGEDSMFAKIFEATRRASQALEGEKTSDGQVEKTTSDEQKPRNKINVKRKSKQLSTLRLKVGHEVLRQRKNWWKDGRFQSEWVGPCIIDYITENGCAILRDATGSRLKRPIKMSHLKPYIRGSNEKDDRYFLQGAIVVDHDYIGLSERSHNTDQQDPAAEKEINAYVRGVTSAVQMPPSACKGQESADGRHQSELTEDHCVEPNSAKPEQWPSPCWTLQTKIEDT", "length": 531 }, "evidence": [ { "id": "A4FUB7", "url": "https://omabrowser.org/oma/group/A4FUB7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HQD3-1", "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "Gin1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVRNGKNGDLHLKQIAYYKRTGEYHPTTLSSERSGIRRAAKKFVFKEKKLFYVGKDRKQNRLVVVSEEEKKKVLRECHENGTGVHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTLLGAPQQHLLTVGSPWSVVTADLMGPFHTSDRSHVYAIIVTDLFTKWVMILPLCDVSASEISKAIINIFFLYGPPQKIVMDQRDEFIEQINTELYRLFGTKQIIISHASGSVSPPESTSSTIKAFLSKHCADHPNTWDEHLPALSFAFNVTPSEPTKNTPYFQMFNRNPYVVECPHDLGGENTSLFARVVAAVREADAVLENKTPSAGQMENNNLEEPNKTKTVKKKPKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYITESGCAVLRDHTGARLKRPIKMSHLRPYVRESTEQDSLYLLQGSVVADHDYIGFPEIPVGAYQANILVEDATIGVADDELLATGKDHELLEYRNSKISVLVEDQSSLEKQTFSLLDSSNQVLEYLS", "length": 518 }, "evidence": [ { "id": "A4FUB7", "url": "https://omabrowser.org/oma/group/A4FUB7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LQC9-1", "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "GIN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKGKKLFYVGKDRKQNRLVIVSEEEKKKVLRECHENDTGAHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKNTVILAPKQHLLKVENPWSIVTVDLMGPFHMSSRSHVYAIIMTDLFTKWVVILPLCDVSASEVSKAITNIFFLYGPPQKIIMDQRDEFIHQINLELCELFGTKQIVISQASQTVNPTESTPSTIKTFLSKHCADHPDNWDDHLSAVSFAFNVIHLEPSKNTPYFQMFNRNPYMPETSDILHEMDGDSTSMFAKILGAVKEADKIMANKTTSAGQMENNSFDELNKSKIIVKKKPKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYITENGCAVLRDNTGTRLKRPIKMSHLKPYVRESSEQDSLYLLQGSVVADHDYIGLPEIPVGAYQANILVEDATIGIVDNELLTSSKDRELLEYRNAKISPLIEDHSTLEKQTFSLLDSSNQVLEYLS", "length": 522 }, "evidence": [ { "id": "A4FUB7", "url": "https://omabrowser.org/oma/group/A4FUB7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q66H30-1", "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "GIN1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLSSERSGIRRAAKKFVFKEKKLFYVGKDRKQNRLVVVSEEEKKKVLRECHENGPGVHHGISRTLTLVESSYYWTSVTNDVKQWVYACQHCQVAKSTVIVAPQQHLSVVGNPWSVVTVDLMGPFHTSSRSHVYAMIMTDLFTKWVMILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIDQINVELYRLFGAKEIVISQASGSVNPSESTPSTVKTFLSKHCAEHPETWDEELPALSFAFNVTRVEPTKNSPYFQMFNRNPCLLECPHEGGGEGTSVFARIVAAVREADGVVENQTPAAGQMESSTSEELSKSKVAKKKPKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYITDSGCAVLRDNTGTRLKRPIKMSHLRPYVREPSEQDSLYLLQGSIVADHDYIGLPEIPVGTYQANILVEDATIGIVDNELLISSKDHELLEYRNSKISALVEDHSSLEKQTFSLLDSSNQVLEYLS", "length": 518 }, "evidence": [ { "id": "A4FUB7", "url": "https://omabrowser.org/oma/group/A4FUB7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K259-1", "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "Gin1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQNRLVVVSEEEKKKVLRECHENGPGVHHGISRTLTLVESGYYWTSVTNDVKQWVYACQHCQVAKNTVIVAPQQHLPMVGNPWSVVTVDLMGPFHTSNRSHVYAIIMTDLFTKWVMILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIEQINVELYRLFGAKEIVISRASGSVNPAENTPSTIKTFLSKHCADHPNSWDEHLPALSFAFNVTHLEPNKNTPYFQMFNRNPCVLECPPEEGSEGTSVFARIVAAIREADGVVENKTPASSQMENNNSDELSKSKVVKKKAKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYITESGCAVLRDNTGTRLKRPIKMSHLRPYVRESSEQDSLYLLQGSIVADHDYIGLPEIPVGTYQANILVEDATIGIADNELLISSKDHELLEYRNSKISALVEDHSSLEKQTFSLLDSSNQVLEYLS", "length": 518 }, "evidence": [ { "id": "A4FUB7", "url": "https://omabrowser.org/oma/group/A4FUB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NXP7-1", "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "GIN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRSGKNGDLHLKQIAYYKRTGEYHSTTLPSERSGIRRAAKKFVFKEKKLFYVGKDRKQNRLVIVSEEEKKKVLRECHENDSGAHHGISRTLTLVESNYYWTSVTNDVKQWVYACQHCQVAKNTVIVAPKQHLLKVENPWSLVTVDLMGPFHTSNRSHVYAIIMTDLFTKWIVILPLCDVSASEVSKAIINIFFLYGPPQKIIMDQRDEFIQQINIELYRLFGIKQIVISHTSGTVNPTESTPNTIKAFLSKHCADHPNNWDDHLSAVSFAFNVTHLEPTKNTPYFQMFSRNPYMPETSDSLHEVDGDNTSMFAKILDAIKEADKIMENKTTSLGQMENNNLDELNKSKIIVKKKPKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYITESGCAVLRDNTGVRLKRPIKMSHLKPYIRESSEQESLYLLQGSVVADHDYIGLPEIPIGAYQANILVEDATIGIVDNELLTSSKDRELLEYRNTKISPLIDDHSSLEKQTFSLLDSSNQVLEYLS", "length": 522 }, "evidence": [ { "id": "A4FUB7", "url": "https://omabrowser.org/oma/group/A4FUB7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A4FUB7", "url": "https://www.uniprot.org/uniprotkb/A4FUB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA integration", "id": "GO:0015074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015074", "evidence": [ { "database": "UniProtKB", "id": "A4FUB7", "url": "https://www.uniprot.org/uniprotkb/A4FUB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A4FUB7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 499, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A4FUB7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A4FUB7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A4FUB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUB7" }, { "id": "PRU00457", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00457" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Integrase catalytic", "eco_id": "ECO_0000255", "start_pos": 113, "end_pos": 270, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 220 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A4IFA8-1", "uniprot_ac": "A4IFA8", "uniprot_id": "CK068_BOVIN", "mass": { "chemical_mass": 31403.0, "monoisotopic_mass": 31403.0 }, "refseq": { "ac": "NP_001098950", "name": "UPF0696 protein C11orf68 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" }, "gene_names": [ { "name": "BLES03", "type": "synonym", "evidence": [ { "id": "NP_001098950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" } ] }, { "name": "C11orf68", "type": "synonym", "evidence": [ { "id": "NP_001098950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" } ] }, { "name": "C29H11orf68", "type": "synonym", "evidence": [ { "id": "NP_001098950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" } ] } ], "protein_names": [ { "name": "UPF0696 protein C11orf68 homolog", "type": "recommended", "evidence": [ { "id": "A4IFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFA8/entry#names_and_taxonomy" } ] }, { "name": "UPF0696 protein C11orf68 homolog", "type": "synonym", "evidence": [ { "id": "NP_001098950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" } ] }, { "name": "basophilic leukemia expressed protein BLES03", "type": "synonym", "evidence": [ { "id": "NP_001098950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" } ] } ], "function": [ { "annotation": "Structural characterization of the human ortholog.", "evidence": [ { "database": "RefSeq", "id": "NP_001098950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" }, { "database": "PubMed", "id": "16511166", "url": "https://glygen.org/publication/PubMed/16511166" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A4IFA8", "url": "https://www.uniprot.org/uniprotkb/A4IFA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A4IFA8", "locus": {} } ], "crossref": [ { "id": "A4IFA8", "url": "https://alphafold.ebi.ac.uk/entry/A4IFA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006195", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006195", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100125880", "url": "https://www.ncbi.nlm.nih.gov/gene/100125880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100125880", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125880", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WIAIYGP", "url": "https://omabrowser.org/oma/group/WIAIYGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A4IFA8", "url": "https://www.orthodb.org/?gene=A4IFA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31977:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31977:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08939", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08939", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A4IFA8", "url": "https://www.uniprot.org/uniprotkb/A4IFA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4IFA8-1", "url": "https://www.uniprot.org/uniprotkb/A4IFA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAAAVAGAGRGGGGGAEPRQERSRARGWAGAERSEGRRMEPGEELEEEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARMTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYIPNSGDVQGLQAAWEALQTSGRPVTPGTLRQLAITHQVLSGKWLIHLAPGFKLDHAWAGIARAVVEGRLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADAAIRAAGVKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGSARGSRVLDRANNVELT", "length": 292, "header": "sp|A4IFA8-1|CK068_BOVIN Isoform 1 of UPF0696 protein C11orf68 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A4IFA8-1" }, "isoforms": [ { "isoform_ac": "A4IFA8-1", "url": "https://www.uniprot.org/uniprotkb/A4IFA8/entry#A4IFA8-1", "sequence": { "sequence": "MAAAAAAVAGAGRGGGGGAEPRQERSRARGWAGAERSEGRRMEPGEELEEEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARMTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYIPNSGDVQGLQAAWEALQTSGRPVTPGTLRQLAITHQVLSGKWLIHLAPGFKLDHAWAGIARAVVEGRLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADAAIRAAGVKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGSARGSRVLDRANNVELT", "length": 292, "header": "sp|A4IFA8-1|CK068_BOVIN Isoform 1 of UPF0696 protein C11orf68 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A4IFA8-1" }, "locus": { "chromosome": "29", "start_pos": 44028080, "end_pos": 44026545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008137.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008137.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008137.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008137.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 152, "start_aa": "Thr", "end_pos": 152, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr152", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.", "journal": "Acta crystallographica. Section F, Structural biology and crystallization communications", "date": "2005", "authors": "Bitto E, Bingman CA, Robinson H, Allard ST, Wesenberg GE, Phillips GN Jr", "evidence": [ { "database": "RefSeq", "id": "NP_001098950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098950" } ], "reference": [ { "type": "PubMed", "id": "16511166", "url": "https://glygen.org/publication/PubMed/16511166" } ] } ], "pathway": [ { "id": "bta:100125880", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125880", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RU27-1", "protein_name": "Chromosome 2 C11orf68 homolog", "gene_name": "C11orf68", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRLSIKLLLRRRGNKMAAAAAAVAGAGRGGGGAEPRQERSRARGWAGAERSEGRRMEPGEELEDEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYVPNSGDVQGLQAAWEALQTSGRPVTPGTLRQLAITHHVLSGKWLIHLAPGFKLDHAWAGIARAVVEGRLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADAAIRAAGIKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGSARGSRVLDRANNVELT", "length": 307 }, "evidence": [ { "id": "A4IFA8", "url": "https://omabrowser.org/oma/group/A4IFA8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q566Q8-1", "protein_name": "UPF0696 protein C11orf68 homolog", "gene_name": "Bles03", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAAAAVAGAGRGGGGGADPGQERSRARSWVGAERSEGRRMEPNEELEEEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYTPNSGDVQGLQAAWEALQTSGRPITPGTLRQLAITHHVLSGKWLIHLAPGFKLDHAWAGIARAVVEGRLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADSAIRAAGIKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGNARGSRVLDRANNVELT", "length": 292 }, "evidence": [ { "id": "A4IFA8", "url": "https://omabrowser.org/oma/group/A4IFA8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NWH0-1", "protein_name": "UPF0696 protein C11orf68 homolog", "gene_name": "", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAADESPASPSELSECFSAEDYAAESLAADLDPWITFDARKTPRAEFSSWLQSHRPSSVSRYGDGEAGAGPVGWIAVRGPDYSEQSGDVEGLQDSWETLLTSGRSVSFQNIRELALNHSVLDGKWLMHLDTGFKVDRAWESIARATVLEGKIWSAKVSPRDPSSNSRHVICVYNQNFTDEEQVVRLDSAIRAAGVKCVLYYKPDVYTYLGIYRNNRWKLCPTIYESMFDLESVPRRSHILNKVTNLELS", "length": 249 }, "evidence": [ { "id": "A4IFA8", "url": "https://omabrowser.org/oma/group/A4IFA8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8VD62-2", "protein_name": "UPF0696 protein C11orf68 homolog", "gene_name": "Bles03", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAAAVAGAGRGGGGGGGGGGAADPGQERSRARSWVGAERSEGRRMEPNEELEEEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYTPNSGDVQGLQAAWEALQTSGRPITPGTLRQLAITHHVLSGKWLIHLSPGFKLDHAWAGIARAVVEGRLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADSAIRAAGIKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGNTRGSRVLDRANNVELT", "length": 298 }, "evidence": [ { "id": "A4IFA8", "url": "https://omabrowser.org/oma/group/A4IFA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H3H3-2", "protein_name": "UPF0696 protein C11orf68", "gene_name": "C11orf68", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAAAAVAGVGRGGGGAEPRQERSRARGWAGVERSEGRRMEPGEELEEEGSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWIAVYGQGYSPNSGDVQGLQAAWEALQTSGRPITPGTLRQLAITHHVLSGKWLMHLAPGFKLDHAWAGIARAVVEGQLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADSAIRAAGIKCLLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGSARGSRVLDRANNVELT", "length": 292 }, "evidence": [ { "id": "A4IFA8", "url": "https://omabrowser.org/oma/group/A4IFA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A4IFA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A4IFA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A4IFA8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 152 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A4IFF3-1", "uniprot_ac": "A4IFF3", "uniprot_id": "TTC9C_BOVIN", "mass": { "chemical_mass": 19919.0, "monoisotopic_mass": 19919.0 }, "refseq": { "ac": "NP_001077261", "name": "tetratricopeptide repeat protein 9C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077261" }, "gene_names": [ { "name": "TTC9C", "type": "recommended", "evidence": [ { "id": "A4IFF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFF3" } ] }, { "name": "TTC9C", "type": "synonym", "evidence": [ { "id": "NP_001077261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077261" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 9C", "type": "recommended", "evidence": [ { "id": "A4IFF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFF3/entry#names_and_taxonomy" } ] }, { "name": "TPR repeat protein 9C", "type": "synonym", "evidence": [ { "id": "NP_001077261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077261" }, { "id": "A4IFF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFF3/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 9C", "type": "synonym", "evidence": [ { "id": "NP_001077261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077261" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A4IFF3", "url": "https://www.uniprot.org/uniprotkb/A4IFF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC9C", "url": "https://www.uniprot.org/uniprotkb/A4IFF3", "locus": { "chromosome": "29", "start_pos": 41052771, "end_pos": 41043943, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000773", "url": "https://www.ensembl.org/id/ENSBTAG00000000773" } ] } } ], "crossref": [ { "id": "A4IFF3", "url": "https://alphafold.ebi.ac.uk/entry/A4IFF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000773", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000773", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786577", "url": "https://www.ncbi.nlm.nih.gov/gene/786577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KIYANMS", "url": "https://omabrowser.org/oma/group/KIYANMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A4IFF3", "url": "https://www.orthodb.org/?gene=A4IFF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14559", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14559", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001077261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077261", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A4IFF3", "url": "https://www.uniprot.org/uniprotkb/A4IFF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4IFF3-1", "url": "https://www.uniprot.org/uniprotkb/A4IFF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKRLQEAQLYKEKGNQCYREGKYRDAVSGYHRALLQLRGLDPSLPSPIPNLGPQGPALTPEQENLLHTTQTDCYNNLAACLLQMEPVNYERVKEYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLMAAVNRKPKDANVRRYLQRTQLELSSYHRKEKQLYLGMFG", "length": 171, "header": "sp|A4IFF3-1|TTC9C_BOVIN Isoform 1 of Tetratricopeptide repeat protein 9C OS=Bos taurus OX=9913 GN=TTC9C PE=2 SV=1 CANONICAL=A4IFF3-1" }, "isoforms": [ { "isoform_ac": "A4IFF3-1", "url": "https://www.uniprot.org/uniprotkb/A4IFF3/entry#A4IFF3-1", "sequence": { "sequence": "MEKRLQEAQLYKEKGNQCYREGKYRDAVSGYHRALLQLRGLDPSLPSPIPNLGPQGPALTPEQENLLHTTQTDCYNNLAACLLQMEPVNYERVKEYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLMAAVNRKPKDANVRRYLQRTQLELSSYHRKEKQLYLGMFG", "length": 171, "header": "sp|A4IFF3-1|TTC9C_BOVIN Isoform 1 of Tetratricopeptide repeat protein 9C OS=Bos taurus OX=9913 GN=TTC9C PE=2 SV=1 CANONICAL=A4IFF3-1" }, "locus": { "chromosome": "29", "start_pos": 41051162, "end_pos": 41044294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001024.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001024.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001024.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001024.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786577", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VLK2-1", "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "TTC9C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKRLQEAQLYKEKGNQCYREGKYRDAVSGYHRALLQLRGLDPSMPSPIPNLGPQGPALTPEQENVLHTTQTDCYNNLAACLLQMEPVNYERVKEYSQKVLERQPDNAKALYRAGVAFFHLQDYDRAQHYLTAAVNRQPKDANVRRYLQRTQLELSSYHRKEKQLYLGMFG", "length": 171 }, "evidence": [ { "id": "A4IFF3", "url": "https://omabrowser.org/oma/group/A4IFF3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3II32-1", "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "Ttc9c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKRLQEAQLFKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPIPNLGPEGPALTPEQENILHTTQTDCYNNLAACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLLAAINRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG", "length": 171 }, "evidence": [ { "id": "A4IFF3", "url": "https://omabrowser.org/oma/group/A4IFF3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6P5P3-1", "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "Ttc9c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKRLQEAQLYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPIPNLGPQGPALTPEQENILHTIQTDCYNNLAACLLQMEPVKYERVREYSQKVLERQPENAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFA", "length": 171 }, "evidence": [ { "id": "A4IFF3", "url": "https://omabrowser.org/oma/group/A4IFF3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q810A3-1", "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "Ttc9c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKRLQEAQVYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPLSSLGPQGPALTPEQENILHTIQTHCYNNLAACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDRARHHLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG", "length": 171 }, "evidence": [ { "id": "A4IFF3", "url": "https://omabrowser.org/oma/group/A4IFF3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N5M4-1", "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "TTC9C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKRLQEAQLYKEEGNQRYREGKYRDAVSRYHRALLQLRGLDPSLPSPLPNLGPQGPALTPEQENILHTTQTDCYNNLAACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYLLAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG", "length": 171 }, "evidence": [ { "id": "A4IFF3", "url": "https://omabrowser.org/oma/group/A4IFF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A4IFF3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 171, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A4IFF3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A4IFF3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A4IFJ0-1", "uniprot_ac": "A4IFJ0", "uniprot_id": "CA226_BOVIN", "mass": { "chemical_mass": 27628.0, "monoisotopic_mass": 27628.0 }, "refseq": { "ac": "NP_001077259", "name": "uncharacterized protein C1orf226 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077259" }, "gene_names": [ { "name": "C3H1orf226", "type": "synonym", "evidence": [ { "id": "NP_001077259", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077259" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C1orf226 homolog", "type": "recommended", "evidence": [ { "id": "A4IFJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C1orf226 homolog", "type": "synonym", "evidence": [ { "id": "NP_001077259", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077259" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A4IFJ0", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0", "locus": {} } ], "crossref": [ { "id": "A4IFJ0", "url": "https://alphafold.ebi.ac.uk/entry/A4IFJ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050790", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050790", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783439", "url": "https://www.ncbi.nlm.nih.gov/gene/783439", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783439", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783439", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ENEGPHP", "url": "https://omabrowser.org/oma/group/ENEGPHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A4IFJ0", "url": "https://www.orthodb.org/?gene=A4IFJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF15429", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15429", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001077259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077259", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A4IFJ0", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4IFJ0-1", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 264, "header": "sp|A4IFJ0-1|CA226_BOVIN Isoform 1 of Uncharacterized protein C1orf226 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A4IFJ0-1" }, "isoforms": [ { "isoform_ac": "A4IFJ0-1", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0/entry#A4IFJ0-1", "sequence": { "sequence": "MFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 264, "header": "sp|A4IFJ0-1|CA226_BOVIN Isoform 1 of Uncharacterized protein C1orf226 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A4IFJ0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 214, "end_pos": 214, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4IFJ0", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0" } ], "site_lbl": "Ser214" }, { "start_pos": 215, "end_pos": 215, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4IFJ0", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0" } ], "site_lbl": "Ser215" }, { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4IFJ0", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0" } ], "site_lbl": "Ser241" }, { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4IFJ0", "url": "https://www.uniprot.org/uniprotkb/A4IFJ0" } ], "site_lbl": "Ser250" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783439", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783439", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L170-1", "protein_name": "Uncharacterized protein C1orf226", "gene_name": "C1orf226", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFENLNTALTPKLQASRSFPHLSKPVAPGSAPLGSGEPGGPGLWVGSSQHLKNLGKAMGAKVNDFLRRKEPSSLGSVGVTEINKTAGAQLASGTDAAPEAWLEDERSVLQETFPRLDPPPPITRKRTPRALKTTQDMLISSQPVLSSLEYGTEPSPGQAQDSAPTAQPDVPADASQPEATMEREERGKVLPNGEVSLSVPDLIHKDSQDESKLKMTECRRASSPSLIERNGFKLSLSPISLAESWEDGSPPPQARTSSLDNEGPHPDLLSFE", "length": 272 }, "evidence": [ { "id": "A4IFJ0", "url": "https://omabrowser.org/oma/group/A4IFJ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "J3QNH8-1", "protein_name": "Predicted gene 7694", "gene_name": "Gm7694", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFENLNTTLTPKLQSSHSFPHLSRPGAPGSIAPGSGEPGGPGLRVGSSQHLRNLGKAVGAKVNDLLRRKESSSLGSVGVLEINKTAGAQLPGGEDAACGPWLEDERSVQEVFPLLDPPPPITRKRTPRALKTTQDMLISSQPVLSNLEYGTESPPGQAQDSPPAAQPISADTSRPESTIEMGEKGEALPNGEVSLLVPDLIHKNTQEEAKLKATEGKKSSSPGPIERNGLKLSLSPISLAESWENSSPPPQARTSSLDNEGLHPDLLSFE", "length": 270 }, "evidence": [ { "id": "A4IFJ0", "url": "https://omabrowser.org/oma/group/A4IFJ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A4IFJ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A4IFJ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A4IFJ0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 214, 215, 241, 250 ], "sequon_annotation_sites": [ { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A4IFN2-1", "uniprot_ac": "A4IFN2", "uniprot_id": "MEDAG_BOVIN", "mass": { "chemical_mass": 34360.0, "monoisotopic_mass": 34360.0 }, "refseq": { "ac": "NP_001077129", "name": "mesenteric estrogen-dependent adipogenesis protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077129" }, "gene_names": [ { "name": "MEDAG", "type": "recommended", "evidence": [ { "id": "A4IFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFN2" } ] }, { "name": "C12H13orf33", "type": "synonym", "evidence": [ { "id": "NP_001077129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077129" } ] }, { "name": "MEDAG", "type": "synonym", "evidence": [ { "id": "NP_001077129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077129" } ] } ], "protein_names": [ { "name": "Mesenteric estrogen-dependent adipogenesis protein", "type": "recommended", "evidence": [ { "id": "A4IFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFN2/entry#names_and_taxonomy" } ] }, { "name": "mesenteric estrogen-dependent adipogenesis protein", "type": "synonym", "evidence": [ { "id": "NP_001077129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077129" } ] }, { "name": "uncharacterized protein C13orf33 homolog", "type": "synonym", "evidence": [ { "id": "NP_001077129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077129" } ] } ], "function": [ { "annotation": "Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.", "evidence": [ { "database": "UniProtKB", "id": "A4IFN2", "url": "https://www.uniprot.org/uniprotkb/A4IFN2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A4IFN2", "url": "https://www.uniprot.org/uniprotkb/A4IFN2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEDAG", "url": "https://www.uniprot.org/uniprotkb/A4IFN2", "locus": { "chromosome": "12", "start_pos": 29997123, "end_pos": 30014621, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008271", "url": "https://www.ensembl.org/id/ENSBTAG00000008271" } ] } } ], "crossref": [ { "id": "A4IFN2", "url": "https://alphafold.ebi.ac.uk/entry/A4IFN2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008271", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008271", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510187", "url": "https://www.ncbi.nlm.nih.gov/gene/510187", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510187", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510187", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MAVWSGS", "url": "https://omabrowser.org/oma/group/MAVWSGS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A4IFN2", "url": "https://www.orthodb.org/?gene=A4IFN2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33769", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33769", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33769:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33769:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001077129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077129", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A4IFN2", "url": "https://www.uniprot.org/uniprotkb/A4IFN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4IFN2-1", "url": "https://www.uniprot.org/uniprotkb/A4IFN2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLESAPAARPSLTSISSGELRSLWTCDCELALLPLGQLLRLQPGAFQLRGDQLVVPAPAEPASARGGFNVFGDGFVRLDGQLYRLSSYMRRYVELTNYCDYKDYRETILSKPMLFFVHVQTKKDSLKERTYAFLVNTRHPKIRRQIEQGMDMVISSVIGESYRLQFDFQEVVKNFFPPGNKVVNGEDLSFAYEFKADALFDFFYWFGLSNSTVKVNGKVLNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDEVFNCNLSPRSSLMEPLVAELPFPCVLESEETPNPFI", "length": 303, "header": "sp|A4IFN2-1|MEDAG_BOVIN Isoform 1 of Mesenteric estrogen-dependent adipogenesis protein OS=Bos taurus OX=9913 GN=MEDAG PE=2 SV=1 CANONICAL=A4IFN2-1" }, "isoforms": [ { "isoform_ac": "A4IFN2-1", "url": "https://www.uniprot.org/uniprotkb/A4IFN2/entry#A4IFN2-1", "sequence": { "sequence": "MAGLESAPAARPSLTSISSGELRSLWTCDCELALLPLGQLLRLQPGAFQLRGDQLVVPAPAEPASARGGFNVFGDGFVRLDGQLYRLSSYMRRYVELTNYCDYKDYRETILSKPMLFFVHVQTKKDSLKERTYAFLVNTRHPKIRRQIEQGMDMVISSVIGESYRLQFDFQEVVKNFFPPGNKVVNGEDLSFAYEFKADALFDFFYWFGLSNSTVKVNGKVLNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDEVFNCNLSPRSSLMEPLVAELPFPCVLESEETPNPFI", "length": 303, "header": "sp|A4IFN2-1|MEDAG_BOVIN Isoform 1 of Mesenteric estrogen-dependent adipogenesis protein OS=Bos taurus OX=9913 GN=MEDAG PE=2 SV=1 CANONICAL=A4IFN2-1" }, "locus": { "chromosome": "12", "start_pos": 30014503, "end_pos": 29998230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010884.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010884.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010884.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010884.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510187", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510187", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LN92-1", "protein_name": "Mesenteric estrogen-dependent adipogenesis", "gene_name": "Medag", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFGWLAGWLLVTGECSITYTRVERGQSHSLSMATAACEPVARPSLTSISSGELRSLWTCDCELALLPLSQLLRLQPGAFQLRGEQLLVPGPGEPAAARGGFNVFGDGLVRLDGQLYRLSSYIKRYVELTNYCDYKDYRETILSKPMLFFVNVQTKKDISKERTYAFLVNTRHPKIRRQIEQGMDMVISSVIGESYRLQFDFQEVVRNFFPPGTIMLNGENLSFTYEFKADALFDFFYWFGLSNSTVKVHGKVLNLTSTNPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDDVFNCNLSPRSSVTEPLLAEFSFPSVLESEETSSQSL", "length": 334 }, "evidence": [ { "id": "A4IFN2", "url": "https://omabrowser.org/oma/group/A4IFN2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RST4-1", "protein_name": "Mesenteric estrogen dependent adiposis", "gene_name": "MEDAG", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGAAGAPAARPSLSSISSGELRSLWTCDCELALLPLAQLLRLQPGAFQLRADQLVVPGPAGPAAARGGFNVFGDGLVRFDGQLYHLSSYMRRYVELTNYCDYKDYRETILSKPMLFFINVQTEKDTSKERTYAFLVNTRHPKIRRQIEQGMDAVISSVIGESYRLEFDFQETVKNFFPPGNKVVNGENLSFAYEFKADALFDFFYWFGLSNSTVKVNGKVLNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDEVFNCNLSPRSSLTEPLLAELPFPCVLESEEIPNQFI", "length": 303 }, "evidence": [ { "id": "A4IFN2", "url": "https://omabrowser.org/oma/group/A4IFN2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GWF9-1", "protein_name": "Mesenteric estrogen-dependent adipogenesis protein isoform X1", "gene_name": "Medag", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATAACEPAARPSLTSISSGELRSLWTCDCELALLPLSQLLRLQPGVFQLRGEQLVVPGPGEPADMRGGFNVFGDGLVNFDGQLYRLSNYIKRYVELTSYSDYKDYRETILSKPMLFFINVQTKKDTSKERTYAFLVNTRHPKIRRQIEQGMDMAISSVIGESYRLQFDFQEVVRNFFLPGTKVLNGENLSFAYEFKADALFDFLYWFGLSNSTVKVQGKVLNLTSMNPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDDVFNCNLSPRSSVTEPLLAELSFPSVLESEESSSQFI", "length": 303 }, "evidence": [ { "id": "A4IFN2", "url": "https://omabrowser.org/oma/group/A4IFN2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q14BA6-1", "protein_name": "Mesenteric estrogen-dependent adipogenesis protein", "gene_name": "Medag", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATAACEPVARPSLTSISSGELRSLWTCDCELALLPLSQLLRLQPGAFQLRGEQLLVPGPGEPAAARGGFNVFGDGLVRLEGQLYRLSSYIKRYVELTNYCDYKDYRETILSKPMVFFINVQTKKDISKERTYAFLVNTRHPKIRRQIEQGMDMVISSVIGESYRLQFDFQEVVKNFFPPGTIVLNGENLSFTYEFKADALFDFFYWFGLSNSTVKVHGKVLNLTSTNPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDDVFNCNLSPRSSVTEPLLAEFSFPSLLECEETSSQLI", "length": 303 }, "evidence": [ { "id": "A4IFN2", "url": "https://omabrowser.org/oma/group/A4IFN2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5VYS4-1", "protein_name": "Mesenteric estrogen-dependent adipogenesis protein", "gene_name": "MEDAG", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAACEPVARPSLTSISSGELRSLWTCDCELALLPLAQLLRLQPGAFQLSGDQLVVARPGEPAAARGGFNVFGDGLVRLDGQLYRLSSYIKRYVELTNYCDYKDYRETILSKPMLFFINVQTKKDTSKERTYAFLVNTRHPKIRRQIEQGMDMVISSVIGESYRLQFDFQEAVKNFFPPGNEVVNGENLSFAYEFKADALFDFFYWFGLSNSVVKVNGKVLNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDDVFNCNLSPRSSLTEPLLAELPFPSVLESEETPNQFI", "length": 303 }, "evidence": [ { "id": "A4IFN2", "url": "https://omabrowser.org/oma/group/A4IFN2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A4IFN2", "url": "https://www.uniprot.org/uniprotkb/A4IFN2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of fat cell differentiation", "id": "GO:0045600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "evidence": [ { "database": "UniProtKB", "id": "A4IFN2", "url": "https://www.uniprot.org/uniprotkb/A4IFN2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A4IFN2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A4IFN2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A4IFN2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 223, "end_pos": 225 }, { "start_pos": 272, "end_pos": 274 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A5JS75-1", "uniprot_ac": "A5JS75", "uniprot_id": "A5JS75_BOVIN", "mass": { "chemical_mass": 21490.0, "monoisotopic_mass": 21490.0 }, "refseq": { "ac": "NP_001091849", "name": "interleukin-22 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" }, "gene_names": [ { "name": "IL22", "type": "recommended", "evidence": [ { "id": "A5JS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5JS75" } ] }, { "name": "IL-22", "type": "synonym", "evidence": [ { "id": "NP_001091849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" } ] }, { "name": "IL22", "type": "synonym", "evidence": [ { "id": "NP_001091849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" } ] } ], "protein_names": [ { "name": "Interleukin 22", "type": "synonym", "evidence": [ { "id": "A5JS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5JS75/entry#names_and_taxonomy" } ] }, { "name": "interleukin-22 precursor", "type": "synonym", "evidence": [ { "id": "NP_001091849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" } ] } ], "function": [ { "annotation": "SNPs in IFNG, IFNGR1 and R2, IL22, and IL22RA1 were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.", "evidence": [ { "database": "RefSeq", "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" }, { "database": "PubMed", "id": "21328101", "url": "https://glygen.org/publication/PubMed/21328101" } ] }, { "annotation": "Study concludes that bovine gamma/delta T cells are important sources of IL-22 and suggest a role for this cytokine in regulating immune responses at mucosal surfaces, including the gut.", "evidence": [ { "database": "RefSeq", "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" }, { "database": "PubMed", "id": "19879340", "url": "https://glygen.org/publication/PubMed/19879340" } ] }, { "annotation": "These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" }, { "database": "PubMed", "id": "27427303", "url": "https://glygen.org/publication/PubMed/27427303" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A5JS75", "url": "https://www.uniprot.org/uniprotkb/A5JS75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL22", "url": "https://www.uniprot.org/uniprotkb/A5JS75", "locus": { "chromosome": "5", "start_pos": 45529263, "end_pos": 45523409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015407", "url": "https://www.ensembl.org/id/ENSBTAG00000015407" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015407", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015407", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507778", "url": "https://www.ncbi.nlm.nih.gov/gene/507778", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507778", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507778", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INFQQPY", "url": "https://omabrowser.org/oma/group/INFQQPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A5JS75", "url": "https://www.orthodb.org/?gene=A5JS75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48488", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48488", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48488:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48488:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14565", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14565", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854691", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A5JS75", "url": "https://www.uniprot.org/uniprotkb/A5JS75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A5JS75-1", "url": "https://www.uniprot.org/uniprotkb/A5JS75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALQKSVGSPLRDTLAAGCLLVMVLCAQRGAAAPITSHCRLNESDFQEPYIFNHTFTLAQKASLADNITDVRLIGNKLFHGIHQVTKRCYVLKQVLNFILEEVLFPQSDKFHPYMEKVVPFFSRLSKKLSQCHVESDNQHIQRNVQNLKNTVKKLGESGEIKVIGELNLLFTTLKRECAQVDQGWKMGY", "length": 190, "header": "tr|A5JS75-1|A5JS75_BOVIN Isoform 1 of Interleukin 22 OS=Bos taurus OX=9913 GN=IL22 PE=4 SV=1 CANONICAL=A5JS75-1" }, "isoforms": [ { "isoform_ac": "A5JS75-1", "url": "https://www.uniprot.org/uniprotkb/A5JS75/entry", "sequence": { "sequence": "MAALQKSVGSPLRDTLAAGCLLVMVLCAQRGAAAPITSHCRLNESDFQEPYIFNHTFTLAQKASLADNITDVRLIGNKLFHGIHQVTKRCYVLKQVLNFILEEVLFPQSDKFHPYMEKVVPFFSRLSKKLSQCHVESDNQHIQRNVQNLKNTVKKLGESGEIKVIGELNLLFTTLKRECAQVDQGWKMGY", "length": 190, "header": "tr|A5JS75-1|A5JS75_BOVIN Isoform 1 of Interleukin 22 OS=Bos taurus OX=9913 GN=IL22 PE=4 SV=1 CANONICAL=A5JS75-1" }, "locus": { "chromosome": "5", "start_pos": 45528783, "end_pos": 45523585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020476.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020476.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020476.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020476.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Expression and regulation of IL-22 by bovine peripheral blood gamma/delta T cells.", "journal": "Gene", "date": "2010-02-01", "authors": "Ma Shi-Dong, Lancto Cheryl A, Enomoto Shinichiro, Abrahamsen Mitchell S, Rutherford Mark S", "evidence": [ { "database": "RefSeq", "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" } ], "reference": [ { "type": "PubMed", "id": "19879340", "url": "https://glygen.org/publication/PubMed/19879340" } ] }, { "title": "Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls.", "journal": "Animal biotechnology", "date": "2011-01", "authors": "Verschoor Chris P, Pant Sameer D, Biggar Graham A, Schenkel Flavio S, Sharma Bhawani S, Karrow Niel A", "evidence": [ { "database": "RefSeq", "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" } ], "reference": [ { "type": "PubMed", "id": "21328101", "url": "https://glygen.org/publication/PubMed/21328101" } ] }, { "title": "CD4+ and \u03b3\u03b4 T Cells are the main Producers of IL-22 and IL-17A in Lymphocytes from Mycobacterium bovis-infected Cattle.", "journal": "Scientific reports", "date": "2016-07-18", "authors": "Steinbach Sabine, Vordermeier H Martin, Jones Gareth J", "evidence": [ { "database": "RefSeq", "id": "NP_001091849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091849" } ], "reference": [ { "type": "PubMed", "id": "27427303", "url": "https://glygen.org/publication/PubMed/27427303" } ] } ], "pathway": [ { "id": "bta:507778", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507778", "resource": "KEGG Pathway" }, { "id": "R-BTA-8854691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "resource": "Reactome", "description": "Interleukin-20 family signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MQU8-1", "protein_name": "Interleukin-22", "gene_name": "Il22", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVLQKKSMSFSFMGLLAASCLLLIALWAQEAVGLPISSHCKLDVSDFQRPYFTNRTFRLAEEASLADNNTDVRLIGDELFQGVNRNNRCYLMKQVLNFTLAEVLIPQSDRFQPYMQQVVPFLTKLSNQLSLCQISGNGQRIQKNVQTLKETVKQLGESGEIKAIGELNLLFMHLRNYCV", "length": 180 }, "evidence": [ { "id": "A5JS75", "url": "https://omabrowser.org/oma/group/A5JS75/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C1U2-1", "protein_name": "Interleukin 22", "gene_name": "IL22", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATLHTLTRSFSGWVVFCCCCCFPLLLTSPLPPKGTGVVSNAHQACRLRKINFQQPYIRNRTYTLAEMARLSDQDTDNRLIGQQIYVNIRENNRCYMMKRITEIIVKDVLLTEAKERYPYAEDVAQFLASLTSELSRCKYSGNREHIEKNLEEMKSKMKELGENGKNKAIGELDLLFDYIENACTDAPKKGGNKKKN", "length": 197 }, "evidence": [ { "id": "A5JS75", "url": "https://omabrowser.org/oma/group/A5JS75/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SH68-1", "protein_name": "Interleukin 22", "gene_name": "IL22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALRTSGSPFLLETLAASCLLLLALWAQGGVAVPITHHCKLDQSNFQQPYITNRTFTLAQEASLADNNTDVRLIGNNLFQGVNQMRERCYLVKQVLNFTLEEVLFPNSDRFHPYMQEVASFLDSLSKKLSQCRIKGDDQHIQRNVNNFKDTVKKLGESGEIKVIGELYLLFMALKNECTLPGHSWKMDN", "length": 190 }, "evidence": [ { "id": "A5JS75", "url": "https://omabrowser.org/oma/group/A5JS75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V6X6-1", "protein_name": "Interleukin 22", "gene_name": "Il22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVLRKSMSFSLMGTLAASCLLLVALWAQKADALPINSQCKLEAANFQQPYIVNRTFMLAKEASLADNNTDVRLIGEELFRGVKAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSSHLSPCHISGDDQNIQKNVRQLKETVQKLGESGEIKAIGELDLLFMSLRNACV", "length": 179 }, "evidence": [ { "id": "A5JS75", "url": "https://omabrowser.org/oma/group/A5JS75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9GZX6-1", "protein_name": "Interleukin-22", "gene_name": "IL22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNACI", "length": 179 }, "evidence": [ { "id": "A5JS75", "url": "https://omabrowser.org/oma/group/A5JS75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJY9-1", "protein_name": "Interleukin-22", "gene_name": "Il22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVLQKSMSFSLMGTLAASCLLLIALWAQEANALPVNTRCKLEVSNFQQPYIVNRTFMLAKEASLADNNTDVRLIGEKLFRGVSAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGEIKAIGELDLLFMSLRNACV", "length": 179 }, "evidence": [ { "id": "A5JS75", "url": "https://omabrowser.org/oma/group/A5JS75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A5JS75", "url": "https://www.uniprot.org/uniprotkb/A5JS75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "A5JS75", "url": "https://www.uniprot.org/uniprotkb/A5JS75" } ], "pmid": "" }, { "name": "positive regulation of biosynthetic process", "id": "GO:0009891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009891", "evidence": [ { "database": "UniProtKB", "id": "A5JS75", "url": "https://www.uniprot.org/uniprotkb/A5JS75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A5JS75", "url": "https://www.uniprot.org/uniprotkb/A5JS75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A5PJK7-1", "uniprot_ac": "A5PJK7", "uniprot_id": "PRR32_BOVIN", "mass": { "chemical_mass": 31084.0, "monoisotopic_mass": 31084.0 }, "refseq": { "ac": "NP_001092658", "name": "proline-rich protein 32", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092658" }, "gene_names": [ { "name": "PRR32", "type": "recommended", "evidence": [ { "id": "A5PJK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJK7" } ] }, { "name": "CXHXorf64", "type": "synonym", "evidence": [ { "id": "NP_001092658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092658" } ] }, { "name": "PRR32", "type": "synonym", "evidence": [ { "id": "NP_001092658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092658" } ] } ], "protein_names": [ { "name": "Proline-rich protein 32", "type": "recommended", "evidence": [ { "id": "A5PJK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJK7/entry#names_and_taxonomy" } ] }, { "name": "proline-rich protein 32", "type": "synonym", "evidence": [ { "id": "NP_001092658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092658" } ] }, { "name": "uncharacterized protein CXorf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001092658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092658" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A5PJK7", "url": "https://www.uniprot.org/uniprotkb/A5PJK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRR32", "url": "https://www.uniprot.org/uniprotkb/A5PJK7", "locus": { "chromosome": "X", "start_pos": 11133667, "end_pos": 11131753, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008763", "url": "https://www.ensembl.org/id/ENSBTAG00000008763" } ] } } ], "crossref": [ { "id": "A5PJK7", "url": "https://alphafold.ebi.ac.uk/entry/A5PJK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008763", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008763", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783116", "url": "https://www.ncbi.nlm.nih.gov/gene/783116", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783116", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783116", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HCFIPPR", "url": "https://omabrowser.org/oma/group/HCFIPPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A5PJK7", "url": "https://www.orthodb.org/?gene=A5PJK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37343:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37343:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15488", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15488", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092658", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A5PJK7", "url": "https://www.uniprot.org/uniprotkb/A5PJK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A5PJK7-1", "url": "https://www.uniprot.org/uniprotkb/A5PJK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACIENVLGGHAPSPTAVAAAENGNREPRPSLPFQCPKDDAGSWGHPGVPLRPPFKVLSDLARERLERPSERTGSCIPVDGWRALKPPYGPPPAVAEEPLATGEVNSSEGPAGWRQSGQDSINNVSQEFSGSPPALMVGGTKVSNGGTERGGSNAGLYVALPRGQGFFPSRGPQVRGPTHISTLRSGIMMELPPGSTRVTGKERLARVSFPLGGPRHPVKNWPRPMPLASSTTGLGSRTTAHCFIPPRPPSFNPFLAMPMAFAPPPIFGPPLPSCFADFPSWGMPAPASSNRENN", "length": 295, "header": "sp|A5PJK7-1|PRR32_BOVIN Isoform 1 of Proline-rich protein 32 OS=Bos taurus OX=9913 GN=PRR32 PE=2 SV=1 CANONICAL=A5PJK7-1" }, "isoforms": [ { "isoform_ac": "A5PJK7-1", "url": "https://www.uniprot.org/uniprotkb/A5PJK7/entry#A5PJK7-1", "sequence": { "sequence": "MACIENVLGGHAPSPTAVAAAENGNREPRPSLPFQCPKDDAGSWGHPGVPLRPPFKVLSDLARERLERPSERTGSCIPVDGWRALKPPYGPPPAVAEEPLATGEVNSSEGPAGWRQSGQDSINNVSQEFSGSPPALMVGGTKVSNGGTERGGSNAGLYVALPRGQGFFPSRGPQVRGPTHISTLRSGIMMELPPGSTRVTGKERLARVSFPLGGPRHPVKNWPRPMPLASSTTGLGSRTTAHCFIPPRPPSFNPFLAMPMAFAPPPIFGPPLPSCFADFPSWGMPAPASSNRENN", "length": 295, "header": "sp|A5PJK7-1|PRR32_BOVIN Isoform 1 of Proline-rich protein 32 OS=Bos taurus OX=9913 GN=PRR32 PE=2 SV=1 CANONICAL=A5PJK7-1" }, "locus": { "chromosome": "X", "start_pos": 11133504, "end_pos": 11131841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011543.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011543.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011543.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011543.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783116", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783116", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2AFE9-1", "protein_name": "Proline-rich protein 32", "gene_name": "Prr32", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACTENGLAGHSHSPIIVPVDKNRSKETCHNVQLRSLSSMLKDDEDDADVWTRPPVSLRPPFNVPRTGARIPQNPRAPRHPLTLTPAIEEESLATAEINSSEGLESQSQKGHDSINMSQEFSGSPMALMIGGPRVGSRVLERSGNNSKPYIPVPRSQGFFPPRGSQSRGPPYIPTLRSGIMMEVTPGNARMANRGNMAHVSFPLGSPRHPMDNWQQSPSLPLSPSITGLPCSSAHCFLPPQAPAFNPFPVMPTAFASPLRFGPPLLPYVFHYNTGAMYPPPYLN", "length": 284 }, "evidence": [ { "id": "A5PJK7", "url": "https://omabrowser.org/oma/group/A5PJK7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1ATL7-1", "protein_name": "Proline-rich protein 32", "gene_name": "PRR32", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACIENVLGGHAPSPLVVSVDKNGNQELHHDMPLQCLSSKPEDDAEPWGQPQVPLRPSVNVLTDLDSKQLEWPSERTGSCIPLHSLRAHRHPYGPPPAVAEESLATAEVNSSDALAGWRQEGQDAINVSWEVSGGPPALIVGGTKVNNGGTERGSNNARLHVALPQGKGFFPPRGPQVRGPSHIPTLRSGIVMEVPPGNTRIACRGKLAHVSFPLRGPCHPMHNWPRPIPLSSSTPGLPSCSTVHCFIPPRPPIFNPFLTMPLPFAPPPIFGPPLPSYFAHFHSGGMPAPASPNREHS", "length": 298 }, "evidence": [ { "id": "A5PJK7", "url": "https://omabrowser.org/oma/group/A5PJK7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1RTJ1-1", "protein_name": "Proline rich 32", "gene_name": "PRR32", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MACTENVLGAHASSATAVAAEEHADREPRPAVQLQCPSSALQGNSESWGHPRLPLRPPFGVLTDLAREQLERPSERTESCIPVNCSRALNPLYRLPPAAAEEALATAEVNSSEGLAGQRQRGQDSIHVSQEFSGGPPVLMVGGTRVSNGSTERGGSSARLYVALPRGQGFLPSRGPQVRGPPHIPTLRSGIMMEVPQGSKRMTSKESLAQVSFPPGGPRHSVENWLRPVPLSSSTPGVPSCATAHCFIPPRPRSFNPFLAMPIAFAPPPLFGPLMPSYFANFPSWGMPAPACSNRENN", "length": 298 }, "evidence": [ { "id": "A5PJK7", "url": "https://omabrowser.org/oma/group/A5PJK7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R6K3-1", "protein_name": "Proline rich 32", "gene_name": "Prr32", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACTENGLGGHSRSSIMVPVDKNGSRETHHNVQLRCLSSMLKDDEDDAEVWPHPPVSLRPSFTMPRTGARIPENPRALRHPFTLAPAIEEESLATAEINRSEGQESQSQKGHDSINMSQEVSASPMALMIGGRVGSGVLERSGNNSKPYIPVPRANGFFPPRGSQSRGPPYIPTLRSGIMMEVTPGNARMAYKGNLAHVSFSLGSPRHPMDNWQQRPPLPLSTNITGLPCSTAHCFLPPQAPAFNPFPVMPTAFASPLGFGPPLLPYFFHYNTGAIYPPPYLN", "length": 283 }, "evidence": [ { "id": "A5PJK7", "url": "https://omabrowser.org/oma/group/A5PJK7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A5PJK7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 295, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A5PJK7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A5PJK7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 124, "end_pos": 126 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6H6X4-1", "uniprot_ac": "A6H6X4", "uniprot_id": "KCTD4_BOVIN", "mass": { "chemical_mass": 29892.0, "monoisotopic_mass": 29892.0 }, "refseq": { "ac": "NP_001092857", "name": "BTB/POZ domain-containing protein KCTD4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092857" }, "gene_names": [ { "name": "KCTD4", "type": "recommended", "evidence": [ { "id": "A6H6X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H6X4" } ] }, { "name": "KCTD4", "type": "synonym", "evidence": [ { "id": "NP_001092857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092857" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD4", "type": "recommended", "evidence": [ { "id": "A6H6X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H6X4/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein KCTD4", "type": "synonym", "evidence": [ { "id": "NP_001092857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092857" } ] }, { "name": "potassium channel tetramerisation domain containing 4", "type": "synonym", "evidence": [ { "id": "NP_001092857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092857" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6H6X4", "url": "https://www.uniprot.org/uniprotkb/A6H6X4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD4", "url": "https://www.uniprot.org/uniprotkb/A6H6X4", "locus": { "chromosome": "12", "start_pos": 15339146, "end_pos": 15350049, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019416", "url": "https://www.ensembl.org/id/ENSBTAG00000019416" } ] } } ], "crossref": [ { "id": "A6H6X4", "url": "https://alphafold.ebi.ac.uk/entry/A6H6X4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019416", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019416", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18364", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18364", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539536", "url": "https://www.ncbi.nlm.nih.gov/gene/539536", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539536", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539536", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GKKPVQH", "url": "https://omabrowser.org/oma/group/GKKPVQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6H6X4", "url": "https://www.orthodb.org/?gene=A6H6X4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19323", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19323", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092857", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6H6X4", "url": "https://www.uniprot.org/uniprotkb/A6H6X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H6X4-1", "url": "https://www.uniprot.org/uniprotkb/A6H6X4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHKINRREKEKDYEGKHNSLEDADQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSISSNTIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259, "header": "sp|A6H6X4-1|KCTD4_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD4 OS=Bos taurus OX=9913 GN=KCTD4 PE=2 SV=1 CANONICAL=A6H6X4-1" }, "isoforms": [ { "isoform_ac": "A6H6X4-1", "url": "https://www.uniprot.org/uniprotkb/A6H6X4/entry#A6H6X4-1", "sequence": { "sequence": "MEHKINRREKEKDYEGKHNSLEDADQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSISSNTIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259, "header": "sp|A6H6X4-1|KCTD4_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD4 OS=Bos taurus OX=9913 GN=KCTD4 PE=2 SV=1 CANONICAL=A6H6X4-1" }, "locus": { "chromosome": "12", "start_pos": 15340593, "end_pos": 15339817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025865.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025865.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025865.2", "url": "https://www.ensembl.org/id/ENSBTAP00000025865.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539536", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539536", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXL9-1", "protein_name": "Potassium channel tetramerization domain containing 4", "gene_name": "Kctd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERKIIRREKEREYEGRHNSLEDAEQGKNCTSTLTTLNVGGYLYITQRQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWKKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSVSSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259 }, "evidence": [ { "id": "A6H6X4", "url": "https://omabrowser.org/oma/group/A6H6X4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BXC9-1", "protein_name": "Potassium channel tetramerization domain containing 4", "gene_name": "KCTD4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERKSNRRAKESEENHSNFEGSEQDKDYKTSLITLNVGGYLYITQKQTLTKYPDSFLEGVINGKIMCPFDADGHYFIDRDGLLFRHILNFLRNGELLLPEGFRENQLLAHEADFFQLKVLSDAVKSRWEKEQLASRETTFLEITDSHDRSQGLRIFCNAPDFIAKIKSRIVLVSKSRLDGFPEEFSVSSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 257 }, "evidence": [ { "id": "A6H6X4", "url": "https://omabrowser.org/oma/group/A6H6X4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H835-1", "protein_name": "BTB/POZ domain-containing protein KCTD4", "gene_name": "Kctd4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MERKIIRREKEREYEGRHNSLEDAEQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGVVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSVSSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259 }, "evidence": [ { "id": "A6H6X4", "url": "https://omabrowser.org/oma/group/A6H6X4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LNK6-1", "protein_name": "Potassium channel tetramerization domain containing 4", "gene_name": "KCTD4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERKINRREKEKEYEGKHNSLEDADQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSISSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259 }, "evidence": [ { "id": "A6H6X4", "url": "https://omabrowser.org/oma/group/A6H6X4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8WVF5-1", "protein_name": "BTB/POZ domain-containing protein KCTD4", "gene_name": "KCTD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERKINRREKEKEYEGKHNSLEDTDQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSISSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259 }, "evidence": [ { "id": "A6H6X4", "url": "https://omabrowser.org/oma/group/A6H6X4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7X1-1", "protein_name": "BTB/POZ domain-containing protein KCTD4", "gene_name": "Kctd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERKIIRREKEREYEGRHNSVEDAEQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSVSSNIIQFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK", "length": 259 }, "evidence": [ { "id": "A6H6X4", "url": "https://omabrowser.org/oma/group/A6H6X4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A6H6X4", "url": "https://www.uniprot.org/uniprotkb/A6H6X4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6H6X4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 259, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6H6X4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6H6X4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6H759-1", "uniprot_ac": "A6H759", "uniprot_id": "LRC72_BOVIN", "mass": { "chemical_mass": 33437.0, "monoisotopic_mass": 33437.0 }, "refseq": { "ac": "NP_001092659", "name": "leucine-rich repeat-containing protein 72", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092659" }, "gene_names": [ { "name": "LRRC72", "type": "recommended", "evidence": [ { "id": "A6H759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H759" } ] }, { "name": "LRRC72", "type": "synonym", "evidence": [ { "id": "NP_001092659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092659" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 72", "type": "recommended", "evidence": [ { "id": "A6H759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H759/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 72", "type": "synonym", "evidence": [ { "id": "NP_001092659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092659" } ] }, { "name": "leucine-rich repeat-containing protein ENSP00000371558 homolog", "type": "synonym", "evidence": [ { "id": "NP_001092659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092659" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6H759", "url": "https://www.uniprot.org/uniprotkb/A6H759" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC72", "url": "https://www.uniprot.org/uniprotkb/A6H759", "locus": { "chromosome": "4", "start_pos": 25084046, "end_pos": 25025019, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034091", "url": "https://www.ensembl.org/id/ENSBTAG00000034091" } ] } } ], "crossref": [ { "id": "A6H759", "url": "https://alphafold.ebi.ac.uk/entry/A6H759", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034091", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034091", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783240", "url": "https://www.ncbi.nlm.nih.gov/gene/783240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783240", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783240", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DWGKMPT", "url": "https://omabrowser.org/oma/group/DWGKMPT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6H759", "url": "https://www.orthodb.org/?gene=A6H759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46759", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46759", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46759:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46759:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6H759", "url": "https://www.uniprot.org/uniprotkb/A6H759", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H759-1", "url": "https://www.uniprot.org/uniprotkb/A6H759-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARDPSHLPRACRPPAIPVRVAEAALEISRTAIEEQLKICGHKKDADVFELFLSQKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLAELYLNNNAIFDIEGLHYLPSLHILLLHHNELINLDATVKELKGMLNLKTLTLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERRSMITLFNHKKAHIVQSIAFRGKVDASWDPRSPFKQKPAQRVPSDFAFANNVDKTMFDDPEDAVFVRSMKRSAMAITSLNWDTVPTREEKYLEEKDTGPAQMLTITLR", "length": 288, "header": "sp|A6H759-1|LRC72_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 72 OS=Bos taurus OX=9913 GN=LRRC72 PE=2 SV=1 CANONICAL=A6H759-1" }, "isoforms": [ { "isoform_ac": "A6H759-1", "url": "https://www.uniprot.org/uniprotkb/A6H759/entry#A6H759-1", "sequence": { "sequence": "MARDPSHLPRACRPPAIPVRVAEAALEISRTAIEEQLKICGHKKDADVFELFLSQKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLAELYLNNNAIFDIEGLHYLPSLHILLLHHNELINLDATVKELKGMLNLKTLTLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERRSMITLFNHKKAHIVQSIAFRGKVDASWDPRSPFKQKPAQRVPSDFAFANNVDKTMFDDPEDAVFVRSMKRSAMAITSLNWDTVPTREEKYLEEKDTGPAQMLTITLR", "length": 288, "header": "sp|A6H759-1|LRC72_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 72 OS=Bos taurus OX=9913 GN=LRRC72 PE=2 SV=1 CANONICAL=A6H759-1" }, "locus": { "chromosome": "4", "start_pos": 25083980, "end_pos": 25025093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048342.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048342.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045403.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045403.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783240", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783240", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1Y7VMI0-1", "protein_name": "Leucine rich repeat containing 72", "gene_name": "Lrrc72", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRNRNSSSFVFPCTKVRKVSVENALPSSLKAVEDQLKICGHKRDIDVLELFLSKKELTEVIDLSRFKKLRYLWLHHNKLHGISFLTRNYCLTELYLNNNAIFEIEGLHNLPSLNILLLHHNELTNIDATMKELKGMQNLRSLSLYQNPLSQYNLYRLYIIFHLPGLELLDRKQITEKERRYMITIFDHKKAHVIQSVAFGKRVDASWNPKLPIKQKRVKKPPSDFAFGDNVDKTLFDDPEDAVFVRSTKRSLMTFTSMNWNTVLTRSEKYDQKKKSSAAEMLMISLR", "length": 288 }, "evidence": [ { "id": "A6H759", "url": "https://omabrowser.org/oma/group/A6H759/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0ABK0L945-1", "protein_name": "Leucine rich repeat containing 72", "gene_name": "Lrrc72", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRNQKSSLPIFPCAKLQKVSENALPSSLKALEDQLKICGHKKDIDVLELFLSKKDLTEVVDLSRFKKLRYLWLHHNKLQGISFLTRNYCLAELYLNHNALFQIEGLHNLPSLNILLLHHNELTNIDATVKELKGMQNLKTLSLYQNPLSQYNLYRLYIIYHLPGLELLDRKEITAKERRNMITIFNHKKTHVLQSIAFGKRADASWNPKLAIKQKRVKKLPSDFAFGDNLDKTVFDDPEDAVFVRSTKRSLMTFTSMNWDTVLTRREKYEKKKSSATQMLMVSLR", "length": 286 }, "evidence": [ { "id": "A6H759", "url": "https://omabrowser.org/oma/group/A6H759/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6NJI9-1", "protein_name": "Leucine-rich repeat-containing protein 72", "gene_name": "LRRC72", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSWDPNPVPRTLRCWRLRRASETALQSSRRAVEDQLKICGHRRDADVFELFLSKKELTEVIDLSRFKKLKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDATVKELKGMLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKERRSMITIFNHKKAHIVQSIAFGGKVDASWDPKSPFKQKPAQRVPSDFAFANNVDKTVLDDPEDAVFVRSMKRSVMTLTSMNWDTVPTREERYLEEEGTETAQMLTVTLR", "length": 287 }, "evidence": [ { "id": "A6H759", "url": "https://omabrowser.org/oma/group/A6H759/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6H759-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 288, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6H759-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6H759" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6H7F9-1", "uniprot_ac": "A6H7F9", "uniprot_id": "CQ078_BOVIN", "mass": { "chemical_mass": 31713.0, "monoisotopic_mass": 31713.0 }, "refseq": { "ac": "NP_001092628", "name": "uncharacterized protein C17orf78 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092628" }, "gene_names": [ { "name": "C17orf78", "type": "synonym", "evidence": [ { "id": "NP_001092628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092628" } ] }, { "name": "C19H17orf78", "type": "synonym", "evidence": [ { "id": "NP_001092628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092628" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C17orf78 homolog", "type": "recommended", "evidence": [ { "id": "A6H7F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F9/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C17orf78 homolog", "type": "synonym", "evidence": [ { "id": "NP_001092628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092628" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6H7F9", "url": "https://www.uniprot.org/uniprotkb/A6H7F9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A6H7F9", "locus": {} } ], "crossref": [ { "id": "A6H7F9", "url": "https://alphafold.ebi.ac.uk/entry/A6H7F9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025242", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025242", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616575", "url": "https://www.ncbi.nlm.nih.gov/gene/616575", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616575", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616575", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FIIFEVP", "url": "https://omabrowser.org/oma/group/FIIFEVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6H7F9", "url": "https://www.orthodb.org/?gene=A6H7F9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36870:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36870:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15829", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15829", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092628", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6H7F9", "url": "https://www.uniprot.org/uniprotkb/A6H7F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H7F9-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTILVFSLIITSYNVTKKELRDSSCQVEPLPDLFPKDVRSIRAELIREAQAEAKRPMFIQNQTVAILQCLGSGSKVKVNLVHSEKRQKVKHILKNLRVMTVPCRNSTAPPSCHLTPASKVQAGFLVTGKAFLPGVSQCKVYPVMGASSETYPSTTTSVTPGKKGEKTTKVDGFSSPLNQDTDENLEKRKKWSIVVKVLIAVTLFVSGIAITVFVIFEVPCPSRCQQVRELCQCQRLRRRPRKEDQQPGTAESQSDTQPKKVGQEAPNSSSPKKAVEITVVHQTYF", "length": 286, "header": "sp|A6H7F9-1|CQ078_BOVIN Isoform 1 of Uncharacterized protein C17orf78 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A6H7F9-1" }, "isoforms": [ { "isoform_ac": "A6H7F9-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F9/entry#A6H7F9-1", "sequence": { "sequence": "MDTILVFSLIITSYNVTKKELRDSSCQVEPLPDLFPKDVRSIRAELIREAQAEAKRPMFIQNQTVAILQCLGSGSKVKVNLVHSEKRQKVKHILKNLRVMTVPCRNSTAPPSCHLTPASKVQAGFLVTGKAFLPGVSQCKVYPVMGASSETYPSTTTSVTPGKKGEKTTKVDGFSSPLNQDTDENLEKRKKWSIVVKVLIAVTLFVSGIAITVFVIFEVPCPSRCQQVRELCQCQRLRRRPRKEDQQPGTAESQSDTQPKKVGQEAPNSSSPKKAVEITVVHQTYF", "length": 286, "header": "sp|A6H7F9-1|CQ078_BOVIN Isoform 1 of Uncharacterized protein C17orf78 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A6H7F9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 160, "start_aa": "Thr", "end_pos": 160, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr160", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616575", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616575", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A521-1", "protein_name": "Similar to human chromosome 17 open reading frame 78", "gene_name": "C10h17orf78", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTILVFSLMIASYDSNKNDLRKSSCQVEQLPSFFPEDVRSNRDLVIRVPPEIHTDIKGAPFIRNQTIATLQCLGSRRRVTVHLVYSERRPKVKYILKNRPVATDLPRNRTASPSCHLRPTSQFQNGFLLTAFLPGISQCTVYPAKDRSALSETVPVTAISTSLRRKGEETPSTGAFPIPLTQDIDLSLKRRQKWSIVVKALIAATLLLSGAAIIVFVIFEVPCPCQCLRARRLCQRQWLWRRERKEEDQQPGTTESKLDSQPEKESILCIVGQDVPNSSASKKTTGTTVIHQTYF", "length": 296 }, "evidence": [ { "id": "A6H7F9", "url": "https://omabrowser.org/oma/group/A6H7F9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S1A5-1", "protein_name": "Chromosome 12 C17orf78 homolog", "gene_name": "C17orf78", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDTILVFSLIITSYDAHKKELRDSSCQVEPLPSLFPKDVRSIRDVLMREAQAEAKRSTFIQNQTVAILQCIGLGSKVKINLAYSEKRGKVKHTLKSLTIVAVPHGNSTASPSCHLTPTSKLQTGSLVIGKAFLPGISQCKAYPVMGASSETFPATTPSITPGNKEREKTTSTDDFSTPLKQDTDEDLKKRQKWSILVKFLIAIILLLGGIAITVFVIFEVPCPTQCLRVREQCRCHRLWRRQKKEGQQPGEAEAQPDSQPKKVGQDVPNSSSPRKAAETTVVHQTYF", "length": 287 }, "evidence": [ { "id": "A6H7F9", "url": "https://omabrowser.org/oma/group/A6H7F9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5QR91-1", "protein_name": "Uncharacterized protein C17orf78 homolog", "gene_name": "Gm11437", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTILVFSLMIASYDSNKNDLRKSSCQVEQWPSFFSEDVRSNKDLVVRVPLEIHTDTKGTPFIQNQPIATLRCLGSGRRVTVHLVYSERRPKVKYIMKNLPVITDLPRNSTASPRCHLRATSQFQNGSLLTAFLPGISQCTVYSAKDRSASSEMVPITTSSTTPRSKGDEATSTGAFPNPLTQGIDMSLKRRQKWSLVVKALIAVTLLLGGAAIIVFVIFEVPCPSQCLRVRQLCQCQWLWRRKRKEEDQKPGTTESQLDSQPEKVKHNVPNSSDSKKTTDIAIIYQTYF", "length": 290 }, "evidence": [ { "id": "A6H7F9", "url": "https://omabrowser.org/oma/group/A6H7F9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N4C9-1", "protein_name": "Uncharacterized protein C17orf78", "gene_name": "C17orf78", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTILVFSLIIASYDANKKDLRDSSCRLEQLPGIFPKDVRSIRELQMQETHTETKRTTFIQNRTIATLQCLGSDSKVKVNLVYLERRPKVKHILKNLRIIAAPRRNSSASSSCHLIPTSKFQTGSLLKGKAFLPGISQCKVLGASSETFPTTAPSITPGNKEGEKTTSTDTDENLEKRQKWSIVVKILIAVTLLLSGVAIIVFVIFEVPCPYQCLGARKLCQCQWLWRWQKKGGQPPGTAESKPDSQPQKVGQDAANSSNPKKAAEITVIHQTYF", "length": 275 }, "evidence": [ { "id": "A6H7F9", "url": "https://omabrowser.org/oma/group/A6H7F9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A6H7F9", "url": "https://www.uniprot.org/uniprotkb/A6H7F9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6H7F9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 286, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6H7F9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6H7F9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 160 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 268, "end_pos": 270 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6H7I3-1", "uniprot_ac": "A6H7I3", "uniprot_id": "ANGE2_BOVIN", "mass": { "chemical_mass": 62348.0, "monoisotopic_mass": 62348.0 }, "refseq": { "ac": "NP_001092580", "name": "RNA 2',3'-cyclic phosphatase ANGEL2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092580" }, "gene_names": [ { "name": "ANGEL2", "type": "recommended", "evidence": [ { "id": "A6H7I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ] }, { "name": "ANGEL2", "type": "synonym", "evidence": [ { "id": "NP_001092580", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092580" } ] } ], "protein_names": [ { "name": "RNA 2',3'-cyclic phosphatase ANGEL2", "type": "recommended", "evidence": [ { "id": "A6H7I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I3/entry#names_and_taxonomy" } ] }, { "name": "3.-.-.-", "type": "synonym", "evidence": [ { "id": "A6H7I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I3/entry#names_and_taxonomy" } ] }, { "name": "RNA 2',3'-cyclic phosphatase ANGEL2", "type": "synonym", "evidence": [ { "id": "NP_001092580", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092580" } ] }, { "name": "protein angel homolog 2", "type": "synonym", "evidence": [ { "id": "NP_001092580", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092580" } ] } ], "function": [ { "annotation": "RNA 2',3'-cyclic phosphatase that catalyzes the hydrolysis of RNA molecules with a 2',3'-cyclic phosphate at the 3' end to produce RNA with a linear 3'-phosphate group. Essential for the maturation and processing of mitochondrial RNAs, particularly those generated via non-canonical pathways. Antagonizes pre-tRNA processing and XBP1 mRNA splicing during the unfolded protein response by limiting the availability of 2',3'-cyclic phosphate substrates for the tRNA ligase complex. Promotes tRNA recycling by eliminating 2',3'-cyclic phosphate groups from cleaved tRNAs, thereby enabling the tRNA nucleotidyltransferase TRNT1 to reattach the CCA tail essential for aminoacylation and subsequent translation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3#function" }, { "database": "UniProtKB", "id": "Q5VTE6", "url": "https://www.uniprot.org/uniprotkb/Q5VTE6#function" }, { "database": "UniProtKB", "id": "Q8K1C0", "url": "https://www.uniprot.org/uniprotkb/Q8K1C0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANGEL2", "url": "https://www.uniprot.org/uniprotkb/A6H7I3", "locus": { "chromosome": "16", "start_pos": 70598523, "end_pos": 70580252, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003702", "url": "https://www.ensembl.org/id/ENSBTAG00000003702" } ] } } ], "crossref": [ { "id": "A6H7I3", "url": "https://alphafold.ebi.ac.uk/entry/A6H7I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003702", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003702", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540507", "url": "https://www.ncbi.nlm.nih.gov/gene/540507", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540507", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540507", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WRPPQFC", "url": "https://omabrowser.org/oma/group/WRPPQFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6H7I3", "url": "https://www.orthodb.org/?gene=A6H7I3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12121:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12121:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092580", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "85011", "url": "https://www.rhea-db.org/rhea/85011", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85191", "url": "https://www.rhea-db.org/rhea/85191", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H7I3-1", "url": "https://www.uniprot.org/uniprotkb/A6H7I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAWRCVRRGYGRCVVGRGRYPMLPHHQKSLGRDWTTPWENLQKCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPGLFESRAPFQYWNWRPDSLSQTSLFHLSSYIMNSEGDEPSSKRRKHQGTIQRHWEYICNHNKENTKILGDENVDPICEDSENKFEFSVMSYNILSQDLLEDNSHLYKHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFYRRDVPLLDRDNVGLVLLLQPKIPSATSPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGRFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKPDGDLTQPELDKTEVLVTAEKLSSNLQHHFSLSSVYSHYLPDTGIPEVTTCHSRSAVTVDYIFYSAEKEGVAEQPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL", "length": 544, "header": "sp|A6H7I3-1|ANGE2_BOVIN Isoform 1 of RNA 2',3'-cyclic phosphatase ANGEL2 OS=Bos taurus OX=9913 GN=ANGEL2 PE=2 SV=1 CANONICAL=A6H7I3-1" }, "isoforms": [ { "isoform_ac": "A6H7I3-1", "url": "https://www.uniprot.org/uniprotkb/A6H7I3/entry#A6H7I3-1", "sequence": { "sequence": "MEAWRCVRRGYGRCVVGRGRYPMLPHHQKSLGRDWTTPWENLQKCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPGLFESRAPFQYWNWRPDSLSQTSLFHLSSYIMNSEGDEPSSKRRKHQGTIQRHWEYICNHNKENTKILGDENVDPICEDSENKFEFSVMSYNILSQDLLEDNSHLYKHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFYRRDVPLLDRDNVGLVLLLQPKIPSATSPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGRFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKPDGDLTQPELDKTEVLVTAEKLSSNLQHHFSLSSVYSHYLPDTGIPEVTTCHSRSAVTVDYIFYSAEKEGVAEQPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL", "length": 544, "header": "sp|A6H7I3-1|ANGE2_BOVIN Isoform 1 of RNA 2',3'-cyclic phosphatase ANGEL2 OS=Bos taurus OX=9913 GN=ANGEL2 PE=2 SV=1 CANONICAL=A6H7I3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:540507", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540507", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B2R2-1", "protein_name": "Angel homolog 2", "gene_name": "ANGEL2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAWRCVRRGYGRCVVGRGRYPMLPHHQKSLGRDWTTPWENLQRCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWKPPCLFESRTQFQSWNWRPDNLSQTSLIHLSSYIMNSEGDEPSSKRRKHQGTIKRHWEYMCNHNKEKTKILGEKNGDPVCDNSENKFDFSVMSYNILSQDLLEDNSHLYRHCRQPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMRTGKKPDGCAICFKHSKFSLLSVNPVEFFRPNVPLLDRDNVGLVLLLQPKSPSAASPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVICGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKTGSDLTQTQVDKTEVLVTDEKLSSNLQHHFSLSSVYSHYFPETGIPEVTTCHSRSAITVDYIFYSAEKEGVAGQQGAGVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLDL", "length": 544 }, "evidence": [ { "id": "A6H7I3", "url": "https://omabrowser.org/oma/group/A6H7I3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z9L6-1", "protein_name": "Angel homolog 2", "gene_name": "ANGEL2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHHLPPARIPHIKAGGPQPRWRLRPHPSLAQHGGPASARAPPEPRWRRDAGRPLDYKSHGRAGERAWPSHRPRGVSGGQGVWRRQAELALPWNDPFWGRQVLAEQLAGPRGAGPGPGLAGRRPMLPRHVQRLGRDWITHVNGSQVFAFSSPVPTCMRWAGHCPWAPFPLPVPVDFSANWRLPLFFGPWRQFQNSNWQLDNFAQNSCIHLPNPSMKAEGEEPVTKKRRLSAQPDSPAPEEVNFSEQKEALCVSVSQDEKSESNKKVNIKRHWEYFCQHSRTMKILESTETDQSNRECEARFDFTVMSYNILSQNLLEDNSHLYKHCRQRLLIWTYRFPNILQEIKQLDADVLCLQEVQEDHYRKEIKSSLESLGYHCEYKMRTGRKSDGCAICFKTSKFSLISSNPVEFFRRDIPLLDRDNVGLVLLLQPKFPCKTNAAICIANTHLLYNPRRGDIKLTQLAMLLAEIASVAPQKNGSFCPIVMCGDFNSVPGSPLYRFIKEGKLNYEGLAIGKVSGQEQFPRGQRILSIPIWPKKLGISQNCVYEIKQQQKEDDAGEKTEGATSDNTKEIVIASEKLSSKLQHHFKLSSVYSHYFPETGLPEVTTCHSRSAVTVDYIFYSAANDDSVAQPGMEDSLHGGLKLLGRLALLTEKDLWTVNGLPNENNSSDHLPLLAEFRLIER", "length": 681 }, "evidence": [ { "id": "A6H7I3", "url": "https://omabrowser.org/oma/group/A6H7I3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LT13-1", "protein_name": "Angel homolog 2", "gene_name": "Angel2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METWRCVRRGYGRCVAGRGRYSMLPYPLKSLGRDWTTPWEDLQKYCWRRHISSCLRWPGHYSRAPYPYFSSRHFSLNCRPPFLFESGTQFQYYNWRPDQLSNTSLFHLSRYVMNSDRDEPSSKRRKHQGTIKRSWEYLCSHNKEKTKDLEDRNGDSTCEDCEDKFDFSVMSYNILSQELLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMKTGRKPDGCAICFKHSKFSLLSVNPVEFCRRDIPLLDRDNIGLVLLLQPKIPRAASPSICIANTHLLYNPRRGDIKLTQLAMLLAEISNVAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEAQQVPKVEKTDSDVTQAQQEKAEVPVPADKVSSHLQHGFSLSSVYSHYVPDTGVPEVTTCHSRSAITVDYIFYSAEKDDTARGPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNEHNSSDHLPLLAKFRLEL", "length": 544 }, "evidence": [ { "id": "A6H7I3", "url": "https://omabrowser.org/oma/group/A6H7I3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5RGT6-1", "protein_name": "RNA 2',3'-cyclic phosphatase angel2", "gene_name": "angel2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRKGRHMPRHTNANYARPGVSPNHPMFGRYLSTVGFPPAQNVYNHWRHWYQPGHLWWTQPPQLQHPSSSFSTVRHPFNRPPRPPDPYQWSSWRQTGVLPHTRGLHLSAGLMESTDRPPPQKRRKSAEGEISQRSPQHSPPKGSRSPKGSPEWLRNVSSIEVANRTSAVPELKRHWEDLSHLCKAAPSVNRGKQKWPFDFSVMSYNILSQDLLCDNTYLYRHCNPPVLDWRNRFPNIIKELEQYSADIMCLQEVQEDHYKQQIKPSLESLGYHCEFKRRTGLKPDGCAVIFKRERFSLVSCHPVEYFRRGVPLMDRDNVGLIVLLRPIDPHVSLSNICVANTHLLYNPRRGDIKLAQLAMLLAEISRVSQLPDSSVCPVLLCGDFNSVPWSPLYRFIKDRRLDYDGMPIGKVSGQEETPRGQRILTVPIWPRSLGISQQCQYENQTRDSELRDLEQTERESFTEASIEHCLRLTSAYSHHLKESGQPEITTCHSRTAITVDYIFYSAALGDVMAQAEYSAPPERGLQLLGRLALVGEKELQKVNGLPNQHNSSDHLPLLTRFRLHPQADS", "length": 569 }, "evidence": [ { "id": "A6H7I3", "url": "https://omabrowser.org/oma/group/A6H7I3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5VTE6-1", "protein_name": "RNA 2',3'-cyclic phosphatase ANGEL2", "gene_name": "ANGEL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAWRCVRKGYGHCVVGRGRYPMFPHHSRSLGRDWTTPWENLQRCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPCLFESRTQFQYCNWRPDNLSQTSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKTKILGDKNVDPKCEDSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRPDISLLDRDNVGLVLLLQPKIPYAACPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFSLSSVYSHYFPDTGIPEVTTCHSRSAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL", "length": 544 }, "evidence": [ { "id": "A6H7I3", "url": "https://omabrowser.org/oma/group/A6H7I3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K1C0-1", "protein_name": "RNA 2',3'-cyclic phosphatase ANGEL2", "gene_name": "Angel2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METWRCVRRGYGRCVAGRGRYSMFPYPLKSLGRDWTTPWEDLQKYCWRRHISSCLRWPGHYSRAPYPYFSSRHFSLNCRPPFLFESGTQFQYYNWRSDHLSNASLIHLSRHVMTSDRDEPLSKRRKHQGTIKRNWEYLCSHNKENTKDLEDRNVDSTCEDREDKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMKTGRKPDGCAICFKHSRFSLLSVNPVEFCRRDIPLLDRDNIGLVLLLQPKIPRAASPSICIANTHLLYNPRRGDIKLTQLAMLLAEIANVTHRKDGSSCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEAQQVPKVEKTDSDVTQAQQEKAEVPVSADKVSSHLQHGFSLSSVYSHYVPDTGVPEVTTCHSRSAITVDYIFYTAKKENTAQGPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNEHNSSDHLPLLAKFRLEL", "length": 544 }, "evidence": [ { "id": "A6H7I3", "url": "https://omabrowser.org/oma/group/A6H7I3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "RNA 2',3'-cyclic phosphatase activity", "id": "GO:0160272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160272", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA stabilization", "id": "GO:0070935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070935", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "negative regulation of RNA splicing", "id": "GO:0033119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033119", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" }, { "name": "negative regulation of tRNA processing", "id": "GO:2000236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000236", "evidence": [ { "database": "UniProtKB", "id": "A6H7I3", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 528, "end_pos": 530, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "85011", "name": "", "equation": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + 2 H2O = a 3'-end ribonucleotide-RNA + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6H7I3-1" ], "evidence": [ { "id": "85011", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85011" } ] }, { "id": "85191", "name": "", "equation": "a 3'-end 2'-phospho-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6H7I3-1" ], "evidence": [ { "id": "85191", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85191" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A6H7I3", "gene_name": "ANGEL2", "activity": [ { "ec_number": "3.-.-.-", "activity": "", "evidence": [ { "id": "A6H7I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6H7I3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 544, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6H7I3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6H7I3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A6H7I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ], "binding_site_uniprot": 220, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 220, "end_pos": 220, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 528, "end_pos": 530 }, { "start_pos": 529, "end_pos": 531 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QLY4-1", "uniprot_ac": "A6QLY4", "uniprot_id": "ISOC1_BOVIN", "mass": { "chemical_mass": 32116.0, "monoisotopic_mass": 32116.0 }, "refseq": { "ac": "NP_001094683", "name": "isochorismatase domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094683" }, "gene_names": [ { "name": "ISOC1", "type": "recommended", "evidence": [ { "id": "A6QLY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY4" } ] }, { "name": "ISOC1", "type": "synonym", "evidence": [ { "id": "NP_001094683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094683" } ] } ], "protein_names": [ { "name": "Isochorismatase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A6QLY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY4/entry#names_and_taxonomy" } ] }, { "name": "isochorismatase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001094683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094683" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLY4", "url": "https://www.uniprot.org/uniprotkb/A6QLY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ISOC1", "url": "https://www.uniprot.org/uniprotkb/A6QLY4", "locus": { "chromosome": "7", "start_pos": 24956654, "end_pos": 24993778, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000341", "url": "https://www.ensembl.org/id/ENSBTAG00000000341" } ] } } ], "crossref": [ { "id": "A6QLY4", "url": "https://alphafold.ebi.ac.uk/entry/A6QLY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000341", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540524", "url": "https://www.ncbi.nlm.nih.gov/gene/540524", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540524", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540524", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QHACANI", "url": "https://omabrowser.org/oma/group/QHACANI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QLY4", "url": "https://www.orthodb.org/?gene=A6QLY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14119:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14119:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26960", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26960", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094683", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QLY4", "url": "https://www.uniprot.org/uniprotkb/A6QLY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLY4-1", "url": "https://www.uniprot.org/uniprotkb/A6QLY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAEPAVPALPGGGGAGAGAPSGTVPVLFCFSVFARPAAVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 298, "header": "sp|A6QLY4-1|ISOC1_BOVIN Isoform 1 of Isochorismatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=ISOC1 PE=2 SV=1 CANONICAL=A6QLY4-1" }, "isoforms": [ { "isoform_ac": "A6QLY4-1", "url": "https://www.uniprot.org/uniprotkb/A6QLY4/entry#A6QLY4-1", "sequence": { "sequence": "MAAAEPAVPALPGGGGAGAGAPSGTVPVLFCFSVFARPAAVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 298, "header": "sp|A6QLY4-1|ISOC1_BOVIN Isoform 1 of Isochorismatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=ISOC1 PE=2 SV=1 CANONICAL=A6QLY4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A6QLY4", "url": "https://www.uniprot.org/uniprotkb/A6QLY4" } ], "site_lbl": "Tyr160" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540524", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540524", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RKJ9-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "ISOC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAEPAVPALPGGGAGAGAPSGTVPVLFCFSVFARPSAVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVSQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 297 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08C33-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "isoc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADTHSNNNHVPVLFSFSVFSRASSVPVGSGYEVLIQKFLSIYGSQIDVHRKLVLQYFSEEWGQYIDLPKGFTVSEKCRLRLVPLQMDITTLGNLSPATSVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVVVSEQYPKGLGSTVQEMDLTGAKLVFPKTKFSMVIPELEAALAEIPGVRSVVLFGVETHVCIQQTALDLIGRGFEVHIVADATSSRSMMDRMFALERLARTGIIITTSESVLLQLVADKEHPKFKEIQNIIKVSAPESGLLSKV", "length": 283 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54NZ6-1", "protein_name": "Isochorismatase family protein 1A", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKSVGNLSPNTSLLFICDIQSKFENHIFKFNDVVGQSKYMIKICNELKVPIIFTEQYPKGLGHTVEDLLKERNENNQTKIFEKTLYSMCTNEVLNHLKQNHKDLKSILITGIETHVCVLQSTLDFLENGYDVHILSDAVSSNNNNDRLIALERMRQSGAFITTTETITFQLTKDAKHKSFKNIVPLSQERREYLLANPSLSSLSKL", "length": 206 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6I7R3-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "Isoc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQVDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLTTLGNLTPPSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVPLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 297 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91V64-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "Isoc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQLDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLTTLGNLTPPSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 297 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96CN7-1", "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "ISOC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAEPAVLALPNSGAGGAGAPSGTVPVLFCFSVFARPSSVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGVEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV", "length": 298 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V9X3-1", "protein_name": "Isochorismatase-like domain-containing protein", "gene_name": "Dmel\\CG11333", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKVRGPALYRLVPSKTLFMLCDVQEKFKPAIPLLSSLIENTTKLLAAGKVFQVPLLVTEQYPERLGKTVCELDIKHACANISKTMFSMLVEPVRKSMTDIFGGKPKTVVLFGLETHVCVEQTAFDLVNDEIDVWLVADCCASRHNQDRDLALERLRHIGCNIATSESVIFNLLGDKNNKSFKEITPLVKKISADMQLCRVSKN", "length": 204 }, "evidence": [ { "id": "A6QLY4", "url": "https://omabrowser.org/oma/group/A6QLY4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6QLY4", "url": "https://www.uniprot.org/uniprotkb/A6QLY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLY4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 298, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLY4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLY4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 160 ], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QNZ4-1", "uniprot_ac": "A6QNZ4", "uniprot_id": "PRR9_BOVIN", "mass": { "chemical_mass": 12851.0, "monoisotopic_mass": 12851.0 }, "refseq": { "ac": "XP_002686070", "name": "proline-rich protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686070" }, "gene_names": [ { "name": "PRR9", "type": "recommended", "evidence": [ { "id": "A6QNZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4" } ] }, { "name": "PRR9", "type": "synonym", "evidence": [ { "id": "XP_002686070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686070" } ] } ], "protein_names": [ { "name": "Proline-rich protein 9", "type": "recommended", "evidence": [ { "id": "A6QNZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4/entry#names_and_taxonomy" } ] }, { "name": "proline-rich protein 9", "type": "synonym", "evidence": [ { "id": "XP_002686070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686070" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QNZ4", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRR9", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4", "locus": { "chromosome": "3", "start_pos": 17262268, "end_pos": 17262618, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050666", "url": "https://www.ensembl.org/id/ENSBTAG00000050666" } ] } } ], "crossref": [ { "id": "A6QNZ4", "url": "https://alphafold.ebi.ac.uk/entry/A6QNZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "100296489", "url": "https://www.ncbi.nlm.nih.gov/gene/100296489", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR052888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296489", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296489", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QNZ4", "url": "https://www.orthodb.org/?gene=A6QNZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48427:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48427:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002686070", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QNZ4", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNZ4-1", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFNEQQCKQPCVPPPCLQKTQEQCQAKAEEVCLPPCQDPCQEKCPTKVQEVCVPQCQALSQDNCPQQSQDPCLPLCPDQCPSQCTEPCQELSQTKCVEVCPQKIQEKCLPPGKGK", "length": 116, "header": "sp|A6QNZ4-1|PRR9_BOVIN Isoform 1 of Proline-rich protein 9 OS=Bos taurus OX=9913 GN=PRR9 PE=4 SV=2 CANONICAL=A6QNZ4-1" }, "isoforms": [ { "isoform_ac": "A6QNZ4-1", "url": "https://www.uniprot.org/uniprotkb/A6QNZ4/entry#A6QNZ4-1", "sequence": { "sequence": "MSFNEQQCKQPCVPPPCLQKTQEQCQAKAEEVCLPPCQDPCQEKCPTKVQEVCVPQCQALSQDNCPQQSQDPCLPLCPDQCPSQCTEPCQELSQTKCVEVCPQKIQEKCLPPGKGK", "length": 116, "header": "sp|A6QNZ4-1|PRR9_BOVIN Isoform 1 of Proline-rich protein 9 OS=Bos taurus OX=9913 GN=PRR9 PE=4 SV=2 CANONICAL=A6QNZ4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296489", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296489", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QNZ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 116, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QNZ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QNZ4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QPA3-1", "uniprot_ac": "A6QPA3", "uniprot_id": "BTBDJ_BOVIN", "mass": { "chemical_mass": 32296.0, "monoisotopic_mass": 32296.0 }, "refseq": { "ac": "NP_001094711", "name": "BTB/POZ domain-containing protein 19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094711" }, "gene_names": [ { "name": "BTBD19", "type": "recommended", "evidence": [ { "id": "A6QPA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPA3" } ] }, { "name": "BTBD19", "type": "synonym", "evidence": [ { "id": "NP_001094711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094711" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein 19", "type": "recommended", "evidence": [ { "id": "A6QPA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPA3/entry#names_and_taxonomy" } ] }, { "name": "BTB (POZ) domain containing 19", "type": "synonym", "evidence": [ { "id": "NP_001094711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094711" } ] }, { "name": "BTB/POZ domain-containing protein 19", "type": "synonym", "evidence": [ { "id": "NP_001094711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094711" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QPA3", "url": "https://www.uniprot.org/uniprotkb/A6QPA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTBD19", "url": "https://www.uniprot.org/uniprotkb/A6QPA3", "locus": { "chromosome": "3", "start_pos": 101200435, "end_pos": 101207043, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039529", "url": "https://www.ensembl.org/id/ENSBTAG00000039529" } ] } } ], "crossref": [ { "id": "A6QPA3", "url": "https://alphafold.ebi.ac.uk/entry/A6QPA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039529", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039529", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18294", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18294", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18494", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18494", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615438", "url": "https://www.ncbi.nlm.nih.gov/gene/615438", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615438", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615438", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWRFHAL", "url": "https://omabrowser.org/oma/group/AWRFHAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QPA3", "url": "https://www.orthodb.org/?gene=A6QPA3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46965", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46965", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46965:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46965:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094711", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QPA3", "url": "https://www.uniprot.org/uniprotkb/A6QPA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPA3-1", "url": "https://www.uniprot.org/uniprotkb/A6QPA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METPGLVVHGEAAPFSTALRSLVNNPLYSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVLEVLTAAVEYGLEELRELCLEFVVKALDVELVCEALQVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 291, "header": "sp|A6QPA3-1|BTBDJ_BOVIN Isoform 1 of BTB/POZ domain-containing protein 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=2 SV=1 CANONICAL=A6QPA3-1" }, "isoforms": [ { "isoform_ac": "A6QPA3-1", "url": "https://www.uniprot.org/uniprotkb/A6QPA3/entry#A6QPA3-1", "sequence": { "sequence": "METPGLVVHGEAAPFSTALRSLVNNPLYSDVRFVVGQERQEVFAHRCLLACRCNFFQRLLSSEPGPGVPSPVVLSTVPAEAFLAVLEFLYTNSAKLQRHSVLEVLTAAVEYGLEELRELCLEFVVKALDVELVCEALQVAVTFGLGQLQERCVAFIEAHSQETLRTRGFLELSAPALLPLLRSDKLCVDEAELVLAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARGTPCRRRRGTLPREHHRFLDLPFK", "length": 291, "header": "sp|A6QPA3-1|BTBDJ_BOVIN Isoform 1 of BTB/POZ domain-containing protein 19 OS=Bos taurus OX=9913 GN=BTBD19 PE=2 SV=1 CANONICAL=A6QPA3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615438", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615438", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N450-1", "protein_name": "BTB/POZ domain-containing protein 19", "gene_name": "Btbd19", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MENPGLAVHGQAAPFSTALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTEPGLVVTSPVVLSTVPPEAFLAVLEFLYTNSVKLHRYSVLEVLTAALEYGLEELRELCLEFVVKVLDVELVCEALQIAVTFGLGRLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDEAELVEAARSWARVGAAVLERPVAEVAAPVVRELRLALLAPAELSALEEQNRREPFIPVEQIVEAWKCHALRRGDAARGATCRRRRGTLPRDHHRFLDLRFK", "length": 291 }, "evidence": [ { "id": "A6QPA3", "url": "https://omabrowser.org/oma/group/A6QPA3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "C9JJ37-1", "protein_name": "BTB/POZ domain-containing protein 19", "gene_name": "BTBD19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPLGLVVHGKAEPFSAALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQFVVKVLDVDLVCEALQVAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDEAELVRAARSWARVGAAVLERPVAEVAAPVVKELRLALLAPAELSALEEQNRQEPLIPVEQIVEAWKCHALRRGDEARGAPCRRRRGTLPREHHRFLDLSFK", "length": 291 }, "evidence": [ { "id": "A6QPA3", "url": "https://omabrowser.org/oma/group/A6QPA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "S4R1I0-1", "protein_name": "BTB domain containing 19", "gene_name": "Btbd19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENPGLVVRGQAAPFSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTAVEYGLEELRELCLEFVVKVLDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARVGAAVLEQPVAEVAAPVVRELRLALLAPAELSALEEQNRREPLIPVEQIVEAWKCHALRRGDAARSAPCRRRRGTRPRDHHRFLDLRFK", "length": 287 }, "evidence": [ { "id": "A6QPA3", "url": "https://omabrowser.org/oma/group/A6QPA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QPA3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 291, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QPA3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QPA3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QPA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPA3" }, { "id": "PRU00037", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000255", "start_pos": 29, "end_pos": 98, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QQA5-1", "uniprot_ac": "A6QQA5", "uniprot_id": "CA074_BOVIN", "mass": { "chemical_mass": 28917.0, "monoisotopic_mass": 28917.0 }, "refseq": { "ac": "NP_001093811", "name": "UPF0739 protein C1orf74 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093811" }, "gene_names": [ { "name": "C16H1orf74", "type": "synonym", "evidence": [ { "id": "NP_001093811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093811" } ] } ], "protein_names": [ { "name": "UPF0739 protein C1orf74 homolog", "type": "recommended", "evidence": [ { "id": "A6QQA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQA5/entry#names_and_taxonomy" } ] }, { "name": "UPF0739 protein C1orf74 homolog", "type": "synonym", "evidence": [ { "id": "NP_001093811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093811" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQA5", "url": "https://www.uniprot.org/uniprotkb/A6QQA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A6QQA5", "locus": {} } ], "crossref": [ { "id": "A6QQA5", "url": "https://alphafold.ebi.ac.uk/entry/A6QQA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002848", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002848", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511599", "url": "https://www.ncbi.nlm.nih.gov/gene/511599", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511599", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511599", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPVTYWF", "url": "https://omabrowser.org/oma/group/YPVTYWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQA5", "url": "https://www.orthodb.org/?gene=A6QQA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31366:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31366:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001093811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093811", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QQA5", "url": "https://www.uniprot.org/uniprotkb/A6QQA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQA5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTPSPQLLVAAAQQTLGMGKRRGPPRAVCLHLAGEVLAVARGLKPALLYDCSSAGAPEIQSYLEKLRGLGFPTQGLHVLEIAENSLIVHPEYVRRHLEQVLLGSIAFVDVSGSQPYPAVCSLDQLQDFKALVVEIITHLQGLQRDRSLAVSCSRLCSSAWNLCTVFGILLGYPVPYTFHENQGEDNCLAQTPLRVFTARISWLCCQPPVLLYSFSVPESLFLSLRDILNTWEKDLRTRCRTQNDFADLSISSEIVTLPAVAL", "length": 263, "header": "sp|A6QQA5-1|CA074_BOVIN Isoform 1 of UPF0739 protein C1orf74 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A6QQA5-1" }, "isoforms": [ { "isoform_ac": "A6QQA5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQA5/entry#A6QQA5-1", "sequence": { "sequence": "MSTPSPQLLVAAAQQTLGMGKRRGPPRAVCLHLAGEVLAVARGLKPALLYDCSSAGAPEIQSYLEKLRGLGFPTQGLHVLEIAENSLIVHPEYVRRHLEQVLLGSIAFVDVSGSQPYPAVCSLDQLQDFKALVVEIITHLQGLQRDRSLAVSCSRLCSSAWNLCTVFGILLGYPVPYTFHENQGEDNCLAQTPLRVFTARISWLCCQPPVLLYSFSVPESLFLSLRDILNTWEKDLRTRCRTQNDFADLSISSEIVTLPAVAL", "length": 263, "header": "sp|A6QQA5-1|CA074_BOVIN Isoform 1 of UPF0739 protein C1orf74 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A6QQA5-1" }, "locus": { "chromosome": "16", "start_pos": 73590257, "end_pos": 73590208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096796.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096796.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077272.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077272.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511599", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511599", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AFS7-1", "protein_name": "Chromosome 1 open reading frame 74", "gene_name": "C1orf74", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGPAARSEAQGVLPAPQLVAAAREALGAGSRRRLAAARALQLAGEVLAVAAGLKPALLYDCGAAGPAELRRYVERLWEAGLGLCRLHLLGVAGDVLLLHPGRARRRLEAALRAHPAPFMDVAAARSSPALCGPAEAAAIRGHLEALLAHLVAAEEAASSPVSCSEVVATGWNLCTVFGVLLGYPAAYTFPVEEGAENCLALTPLRVFTAQASCPRIQGGLRVQIYSFSIPESLCMELQEVLDAWREELRDDFCAQSDFIDLCISSEVVLLPAVAL", "length": 275 }, "evidence": [ { "id": "A6QQA5", "url": "https://omabrowser.org/oma/group/A6QQA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SF50-1", "protein_name": "Chromosome 9 C1orf74 homolog", "gene_name": "C1orf74", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSTLSLQLLVAAAQQTLGMGRSRGPPRAVCLHLAGEVLAVARGLKPALLYDCNCAGAAELQSYLEQLQGLGFPTRGLHILEIGEDSLIVCPERVCQHLEQVLLGSVAFVDVSSAQPHPSVCSLDQLQDLKALLAEIIAHLQGLKTDLSLAVSSSRLCSSDWNLCTVFGILLGYPVPYTFHVSQGGDNCLALTPLRVFTARISWRHSQPPVLLYSFSVPESLFPALRDILNTWEKDLRTRCRTQNDFADLSISSEVVTLPAVAL", "length": 263 }, "evidence": [ { "id": "A6QQA5", "url": "https://omabrowser.org/oma/group/A6QQA5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q567C3-1", "protein_name": "UPF0739 protein C1orf74 homolog", "gene_name": "", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVASSPETLISAAQKCLCSRKKRLSPSSCLEVTIHIIAVDLGVKPALLYDSNGASPDQLQLYLHSLQESSVVSNSLRIMSINDNTFIINPDIMKSHLGELLKSKSLPLIDVCSSRKRPVLCAFERSAEEMVRSFLEVFMNGLDLVVLEEELYKDWNLCTFFGILLGYPASYWFEQTQGFENCLSMTPLVVCTVWVRWQIHEIKQRCCLYSFSVPEELWSDVQSHIQRWTDHLRERFSKQTVLTDICFSRDTVTLPSVTL", "length": 259 }, "evidence": [ { "id": "A6QQA5", "url": "https://omabrowser.org/oma/group/A6QQA5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5U2R2-1", "protein_name": "UPF0739 protein C1orf74 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTPSPQLLVAAAQRTLGMGKRKCPPRATCLHLAGEVLAVARGLKPAVLYDCNSAGVLALQSYLEELQGLGFLKPGLHILEIGENNLIVSPEYTCQHLEQTLLGTVAFVDVSCSQPHPSVLSLDQLPGLKSLIADIITRFQELLKGVSPGVSYSKLHSSDWNLCTLFGILLGYPVSYTFDLNHGEGNCLTMTPLRVFTAQISWLSGQPPVPLYSFSVPESLFPPLRNFLSAWEKELRTRFRAQNAFADLSISSEVVTLPAVAL", "length": 263 }, "evidence": [ { "id": "A6QQA5", "url": "https://omabrowser.org/oma/group/A6QQA5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96LT6-1", "protein_name": "UPF0739 protein C1orf74", "gene_name": "C1orf74", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLLDLMSSPSPQLLVAAAQQTLGMGKRRSPPQAICLHLAGEVLAVARGLKPAVLYDCNCAGASELQSYLEELKGLGFLTFGLHILEIGENSLIVSPEHVCQHLEQVLLGTIAFVDVSSCQRHPSVCSLDQLQDLKALVAEIITHLQGLQRDLSLAVSYSRLHSSDWNLCTVFGILLGYPVPYTFHLNQGDDNCLALTPLRVFTARISWLLGQPPILLYSFSVPESLFPGLRDILNTWEKDLRTRFRTQNDFADLSISSEIVTLPAVAL", "length": 269 }, "evidence": [ { "id": "A6QQA5", "url": "https://omabrowser.org/oma/group/A6QQA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAE8-1", "protein_name": "UPF0739 protein C1orf74 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTPSPQLLVAAAQQTLGMGKRKCPPRATCLHLAGEVLAVARGLKPAVLYDCNSAGVLALQSYLEELQGLGFLEPGLHILEIGENNFIVSPEYACQHLEQTLLGTVAFVDVSRSQPHPSVRSVDQLPDLKSLIADVITRFRGLKKDVSQGVSYTRLHSSDWNLCTVFGILLGYPVSYTFDLNREDDNCLTMTPLRVFTARISWLPGQPSILLYSFSVPESLFPALKNFLSAWEKELRTRFRAQNAFADLSISSEVVTLPAVAL", "length": 263 }, "evidence": [ { "id": "A6QQA5", "url": "https://omabrowser.org/oma/group/A6QQA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 263, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQA5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A6QQF7-1", "uniprot_ac": "A6QQF7", "uniprot_id": "FA89A_BOVIN", "mass": { "chemical_mass": 18888.0, "monoisotopic_mass": 18888.0 }, "refseq": { "ac": "NP_001094727", "name": "protein FAM89A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094727" }, "gene_names": [ { "name": "FAM89A", "type": "recommended", "evidence": [ { "id": "A6QQF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQF7" } ] }, { "name": "FAM89A", "type": "synonym", "evidence": [ { "id": "NP_001094727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094727" } ] } ], "protein_names": [ { "name": "Protein FAM89A", "type": "recommended", "evidence": [ { "id": "A6QQF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQF7/entry#names_and_taxonomy" } ] }, { "name": "protein FAM89A", "type": "synonym", "evidence": [ { "id": "NP_001094727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094727" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQF7", "url": "https://www.uniprot.org/uniprotkb/A6QQF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM89A", "url": "https://www.uniprot.org/uniprotkb/A6QQF7", "locus": { "chromosome": "28", "start_pos": 3750980, "end_pos": 3770591, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023073", "url": "https://www.ensembl.org/id/ENSBTAG00000023073" } ] } } ], "crossref": [ { "id": "A6QQF7", "url": "https://alphafold.ebi.ac.uk/entry/A6QQF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023073", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023073", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616421", "url": "https://www.ncbi.nlm.nih.gov/gene/616421", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:616421", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616421", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMENGFF", "url": "https://omabrowser.org/oma/group/MMENGFF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQF7", "url": "https://www.orthodb.org/?gene=A6QQF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46949", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46949", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46949:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46949:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001094727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094727", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QQF7", "url": "https://www.uniprot.org/uniprotkb/A6QQF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQF7-1", "url": "https://www.uniprot.org/uniprotkb/A6QQF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGAGAAGSVRGLRVDGLPPLPKSLSGLLHSASGGGASGGWRHLERLYAQKSRIQDELSRGSAGGGGARAAALPAKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAAASPDSTYALENGFFDEEDEYFQEQNSLQDGKERGPPRDLMLPVSPLPSGDWILESI", "length": 178, "header": "sp|A6QQF7-1|FA89A_BOVIN Isoform 1 of Protein FAM89A OS=Bos taurus OX=9913 GN=FAM89A PE=2 SV=1 CANONICAL=A6QQF7-1" }, "isoforms": [ { "isoform_ac": "A6QQF7-1", "url": "https://www.uniprot.org/uniprotkb/A6QQF7/entry#A6QQF7-1", "sequence": { "sequence": "MSGAGAAGSVRGLRVDGLPPLPKSLSGLLHSASGGGASGGWRHLERLYAQKSRIQDELSRGSAGGGGARAAALPAKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAAASPDSTYALENGFFDEEDEYFQEQNSLQDGKERGPPRDLMLPVSPLPSGDWILESI", "length": 178, "header": "sp|A6QQF7-1|FA89A_BOVIN Isoform 1 of Protein FAM89A OS=Bos taurus OX=9913 GN=FAM89A PE=2 SV=1 CANONICAL=A6QQF7-1" }, "locus": { "chromosome": "28", "start_pos": 3770550, "end_pos": 3751808, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031376.4", "url": "https://www.ensembl.org/id/ENSBTAT00000031376.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031331.3", "url": "https://www.ensembl.org/id/ENSBTAP00000031331.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616421", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616421", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BHS1-1", "protein_name": "Protein FAM89A", "gene_name": "FAM89A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGAGAASSVRGLRVDGLPPLPKSLSGLLHSASGGGASGGWRHLERLYAQKSRIQDELSRSGAGGGGARATVLPAKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAACSPDGTYALENGFFEEEEEYFQEQDHLQDSRERGPPRDLPRPVSPIPSRDWVLGSL", "length": 178 }, "evidence": [ { "id": "A6QQF7", "url": "https://omabrowser.org/oma/group/A6QQF7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14BJ1-1", "protein_name": "Protein FAM89A", "gene_name": "Fam89a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGTGSAGMARGLRVDGLPPLPKSLSGLLHSAAGGAAGGWRHLERLYAQKSRIQDELNRGGAGGGGARAAGMRTKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAASSLDCTYALENGFFDDEEDFQEQGSLQDGQHHGSPRDQSPLTHLSSSDWILESI", "length": 175 }, "evidence": [ { "id": "A6QQF7", "url": "https://omabrowser.org/oma/group/A6QQF7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6Q0N2-1", "protein_name": "Protein FAM89A", "gene_name": "Fam89a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGAGSAGMARGLRVDGLPPLPKSLSGLLHSAAGGAAGGWRHLERLYAQKSRIQDELNRGGAGGGGARAAGMRTKPPNLDAALALLRKEMVGLRQLDMTLLCQLYGLYESIQEYKGACQAASSLDCNYALENGFFDDDEDFQEQGSLRDGQGRGSPGDPSLPLTHLSSSDWILESI", "length": 176 }, "evidence": [ { "id": "A6QQF7", "url": "https://omabrowser.org/oma/group/A6QQF7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96GI7-1", "protein_name": "Protein FAM89A", "gene_name": "FAM89A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGARAAPGAAGNGAVRGLRVDGLPPLPKSLSGLLHSASGGGASGGWRHLERLYAQKSRIQDELSRGGPGGGGARAAALPAKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAASSPDCTYALENGFFDEEEEYFQEQNSLHDRRDRGPPRDLSLPVSSLSSSDWILESI", "length": 184 }, "evidence": [ { "id": "A6QQF7", "url": "https://omabrowser.org/oma/group/A6QQF7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 178, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQF7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A7E2Y6-1", "uniprot_ac": "A7E2Y6", "uniprot_id": "MROH1_BOVIN", "mass": { "chemical_mass": 182135.0, "monoisotopic_mass": 182135.0 }, "refseq": { "ac": "NP_001095488", "name": "maestro heat-like repeat-containing protein family member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488" }, "gene_names": [ { "name": "MROH1", "type": "recommended", "evidence": [ { "id": "A7E2Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ] }, { "name": "HEATR7A", "type": "synonym", "evidence": [ { "id": "NP_001095488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488" }, { "id": "A7E2Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ] }, { "name": "MROH1", "type": "synonym", "evidence": [ { "id": "NP_001095488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488" } ] } ], "protein_names": [ { "name": "Maestro heat-like repeat-containing protein family member 1", "type": "recommended", "evidence": [ { "id": "A7E2Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6/entry#names_and_taxonomy" } ] }, { "name": "HEAT repeat containing 7A", "type": "synonym", "evidence": [ { "id": "NP_001095488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488" } ] }, { "name": "HEAT repeat-containing protein 7A", "type": "synonym", "evidence": [ { "id": "NP_001095488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488" }, { "id": "A7E2Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6/entry#names_and_taxonomy" } ] }, { "name": "maestro heat-like repeat-containing protein family member 1", "type": "synonym", "evidence": [ { "id": "NP_001095488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488" } ] } ], "function": [ { "annotation": "Lysosome fission factor. Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules. May sever membranes by inserting amphipathic helices into one bilayer leaflet. Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration.", "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6#function" }, { "database": "UniProtKB", "id": "Q8NDA8", "url": "https://www.uniprot.org/uniprotkb/Q8NDA8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MROH1", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6", "locus": { "chromosome": "14", "start_pos": 652603, "end_pos": 702505, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014458", "url": "https://www.ensembl.org/id/ENSBTAG00000014458" } ] } } ], "crossref": [ { "id": "A7E2Y6", "url": "https://alphafold.ebi.ac.uk/entry/A7E2Y6", "database": "AlphaFoldDB", "categories": [] }, { "id": "515055", "url": "https://www.ncbi.nlm.nih.gov/gene/515055", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515055", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515055", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A7E2Y6", "url": "https://www.orthodb.org/?gene=A7E2Y6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23120", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23120", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23120:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23120:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095488", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E2Y6-1", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSETYAKRLSAILLDAVTDKDPQMQEQVCGALCDFGESKPAEVLSACEEHLRLHEKLAHPYRTIILRAMEIVVSNHISELDKDTARAIILLASNEMTKVKELVSDWQQAASSVLVAVGRRFISSVMEELLSKFQPGLLPHPCTVHTLASLSVSNVFGVVPFLTSILSTMLPMLGAAKHDSMKVVFCCALQRFSESILEYLANLDQAPDPTVRKDAFASDIFGAYDILFHQWLQSGGAKLRLAVVEALGPMSHLLPSEKLEEQLPKLLPRVLAFYKKHTETVHVSKSLGQILEAAVSVGSRTLDIHLNSLLAALHAQICVPVESSSPLVMSNQKEVLRCFTVLACCSPDRLLAFLLPKLDTSNERTRVGTLQVLRHVINAAAAQMEVKKPVILSSMKLPLLDTNNKVKRAVVQVVSAMAHHGYLEQPGGKAMVEYIVQQCALPPEAEIQKLGADSEALAADSVRAISVSTLYLVSTTVDRMGEVLWPYLLEFLVPIRFTRALSPLCRSLVHLAQKRQEAGAHAPLIQYNGNVHLPSPYAITTRLLAVSSHPYVGDGRGAASLRLLNVLHQDIHPALGQRWVTAIPLLLEHLDEYSEETLSQKEWEEKLLVFLRDSLAVVSDNTWVCHLTLEMCKQLPNYNGTPLEKNFLYKCVGTTLGAASSKVVRKHLRELLETARYQEEREHEGLACCFGICAISHLDDTLAQLDDFVKSDVLRKSAGIFNLFKNRSESEANKVRSALILCYGHVAAGAPRELLLARVEADLFWNMSECFSTKVLGIKVETQDPALRLSLVQSVCMATQAICSSAHSSSFHLSRKAELVAQMVEFIRAEPPDSLKTPIWKKAMLACTYLVTLEPALEEQVQADLIHSCLHRVMAVLPEPEEGDSPQEVSAAPTVGGDPQESLYLDTVQVLKDLLTSLLLWNMTPLGLQVMLEHLSPWIKSPRGHERVRAVGLSACLLQFFLQHLQISALVPFHNLGLLIGLFSPRCADLWPATRREAVSCIHSLLYLQLTCVGFSRDYQDDVAEQLLSLKDGLVHPDPAILFHTCHSIAQLIAKRLPPDHLINLLLTLFESLGDPDKNCSRAASVMINCLLKERGNMLQEKVPEIVSVLRSKLQETQEEHILQAAQHSVFALATHHCASVVSNLLGSPLPFDSHTCTLWRALALEPGLAAQVLGLLLEKISKDVLFEESQAFLLSSTPDRVATLLPLAATCALHEVASAPASGPAVLELYPQLFVALLLRVSCTVGVQPPRQLQAKERRSASSGLASRSLEPCSSAVDALQAVLVRGGNEDVVQCMELDGGWQLLRTSAGHEEGVTRLASAMAKFAGPRLPLVMKLLFTTQSSMYEVQRVTSTAFLAELLSSNVVNDLMLLESLLYNLMARQKDTSARVRRLVLHGLANITLGSPDKVQTHSPQLLTAMIGGLDDGDDPHSLVALEAMVGLARLMDLVDAWDLHAVLLHIAVRIRPFFDSERMELRSVSIGLFGHLNKACRGDCKDVFLEQVVGGLVPLLLHLRDPHAPVVTACRFALRMCGPNLECEELAAVFQRHLQEGHDLHFGEFLNTTCKHLMRHFPDLLGRLLSTSLFYYKSSWEDVRAAAPMLTGFLVLHMEAEQRPQVDLEQLLTALQLLLKDPALKVRLKAVKTLGRLVKFA", "length": 1652, "header": "sp|A7E2Y6-1|MROH1_BOVIN Isoform 1 of Maestro heat-like repeat-containing protein family member 1 OS=Bos taurus OX=9913 GN=MROH1 PE=2 SV=1 CANONICAL=A7E2Y6-1" }, "isoforms": [ { "isoform_ac": "A7E2Y6-1", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6/entry#A7E2Y6-1", "sequence": { "sequence": "MSETYAKRLSAILLDAVTDKDPQMQEQVCGALCDFGESKPAEVLSACEEHLRLHEKLAHPYRTIILRAMEIVVSNHISELDKDTARAIILLASNEMTKVKELVSDWQQAASSVLVAVGRRFISSVMEELLSKFQPGLLPHPCTVHTLASLSVSNVFGVVPFLTSILSTMLPMLGAAKHDSMKVVFCCALQRFSESILEYLANLDQAPDPTVRKDAFASDIFGAYDILFHQWLQSGGAKLRLAVVEALGPMSHLLPSEKLEEQLPKLLPRVLAFYKKHTETVHVSKSLGQILEAAVSVGSRTLDIHLNSLLAALHAQICVPVESSSPLVMSNQKEVLRCFTVLACCSPDRLLAFLLPKLDTSNERTRVGTLQVLRHVINAAAAQMEVKKPVILSSMKLPLLDTNNKVKRAVVQVVSAMAHHGYLEQPGGKAMVEYIVQQCALPPEAEIQKLGADSEALAADSVRAISVSTLYLVSTTVDRMGEVLWPYLLEFLVPIRFTRALSPLCRSLVHLAQKRQEAGAHAPLIQYNGNVHLPSPYAITTRLLAVSSHPYVGDGRGAASLRLLNVLHQDIHPALGQRWVTAIPLLLEHLDEYSEETLSQKEWEEKLLVFLRDSLAVVSDNTWVCHLTLEMCKQLPNYNGTPLEKNFLYKCVGTTLGAASSKVVRKHLRELLETARYQEEREHEGLACCFGICAISHLDDTLAQLDDFVKSDVLRKSAGIFNLFKNRSESEANKVRSALILCYGHVAAGAPRELLLARVEADLFWNMSECFSTKVLGIKVETQDPALRLSLVQSVCMATQAICSSAHSSSFHLSRKAELVAQMVEFIRAEPPDSLKTPIWKKAMLACTYLVTLEPALEEQVQADLIHSCLHRVMAVLPEPEEGDSPQEVSAAPTVGGDPQESLYLDTVQVLKDLLTSLLLWNMTPLGLQVMLEHLSPWIKSPRGHERVRAVGLSACLLQFFLQHLQISALVPFHNLGLLIGLFSPRCADLWPATRREAVSCIHSLLYLQLTCVGFSRDYQDDVAEQLLSLKDGLVHPDPAILFHTCHSIAQLIAKRLPPDHLINLLLTLFESLGDPDKNCSRAASVMINCLLKERGNMLQEKVPEIVSVLRSKLQETQEEHILQAAQHSVFALATHHCASVVSNLLGSPLPFDSHTCTLWRALALEPGLAAQVLGLLLEKISKDVLFEESQAFLLSSTPDRVATLLPLAATCALHEVASAPASGPAVLELYPQLFVALLLRVSCTVGVQPPRQLQAKERRSASSGLASRSLEPCSSAVDALQAVLVRGGNEDVVQCMELDGGWQLLRTSAGHEEGVTRLASAMAKFAGPRLPLVMKLLFTTQSSMYEVQRVTSTAFLAELLSSNVVNDLMLLESLLYNLMARQKDTSARVRRLVLHGLANITLGSPDKVQTHSPQLLTAMIGGLDDGDDPHSLVALEAMVGLARLMDLVDAWDLHAVLLHIAVRIRPFFDSERMELRSVSIGLFGHLNKACRGDCKDVFLEQVVGGLVPLLLHLRDPHAPVVTACRFALRMCGPNLECEELAAVFQRHLQEGHDLHFGEFLNTTCKHLMRHFPDLLGRLLSTSLFYYKSSWEDVRAAAPMLTGFLVLHMEAEQRPQVDLEQLLTALQLLLKDPALKVRLKAVKTLGRLVKFA", "length": 1652, "header": "sp|A7E2Y6-1|MROH1_BOVIN Isoform 1 of Maestro heat-like repeat-containing protein family member 1 OS=Bos taurus OX=9913 GN=MROH1 PE=2 SV=1 CANONICAL=A7E2Y6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Assessment of the gene content of the chromosomal regions flanking bovine DGAT1.", "journal": "Genomics", "date": "2004", "authors": "Winter Andreas, Alzinger Ariane, Fries Ruedi", "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ], "reference": [ { "type": "PubMed", "id": "14667821", "url": "https://glygen.org/publication/PubMed/14667821" } ] } ], "pathway": [ { "id": "bta:515055", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515055", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane destabilizing activity", "id": "GO:0140912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140912", "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lysosome fission", "id": "GO:0170064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170064", "evidence": [ { "database": "UniProtKB", "id": "A7E2Y6", "url": "https://www.uniprot.org/uniprotkb/A7E2Y6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1079, "end_pos": 1081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1562, "end_pos": 1564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 639, "end_pos": 641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 726, "end_pos": 728, "annotation": "n_glycosylation_sequon" }, { "start_pos": 766, "end_pos": 768, "annotation": "n_glycosylation_sequon" }, { "start_pos": 922, "end_pos": 924, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7E2Y6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1652, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7E2Y6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7E2Y6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1079, "end_pos": 1081 }, { "start_pos": 1400, "end_pos": 1402 }, { "start_pos": 1562, "end_pos": 1564 }, { "start_pos": 639, "end_pos": 641 }, { "start_pos": 726, "end_pos": 728 }, { "start_pos": 766, "end_pos": 768 }, { "start_pos": 922, "end_pos": 924 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A7MB34-1", "uniprot_ac": "A7MB34", "uniprot_id": "F181B_BOVIN", "mass": { "chemical_mass": 41983.0, "monoisotopic_mass": 41983.0 }, "refseq": { "ac": "NP_001094693", "name": "protein FAM181B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094693" }, "gene_names": [ { "name": "FAM181B", "type": "recommended", "evidence": [ { "id": "A7MB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB34" } ] }, { "name": "FAM181B", "type": "synonym", "evidence": [ { "id": "NP_001094693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094693" } ] } ], "protein_names": [ { "name": "Protein FAM181B", "type": "recommended", "evidence": [ { "id": "A7MB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB34/entry#names_and_taxonomy" } ] }, { "name": "protein FAM181B", "type": "synonym", "evidence": [ { "id": "NP_001094693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094693" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB34", "url": "https://www.uniprot.org/uniprotkb/A7MB34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM181B", "url": "https://www.uniprot.org/uniprotkb/A7MB34", "locus": { "chromosome": "29", "start_pos": 12927320, "end_pos": 12925471, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006812", "url": "https://www.ensembl.org/id/ENSBTAG00000006812" } ] } } ], "crossref": [ { "id": "A7MB34", "url": "https://alphafold.ebi.ac.uk/entry/A7MB34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006812", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006812", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613623", "url": "https://www.ncbi.nlm.nih.gov/gene/613623", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613623", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613623", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PNFFTDC", "url": "https://omabrowser.org/oma/group/PNFFTDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB34", "url": "https://www.orthodb.org/?gene=A7MB34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33766", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33766", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33766:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33766:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MB34", "url": "https://www.uniprot.org/uniprotkb/A7MB34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB34-1", "url": "https://www.uniprot.org/uniprotkb/A7MB34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVQAALLSTHPFVPFGFGGSPDGLGGAFGALEKGCCFEDEETGTPAGALLAGAESGDAREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGAAPPGPSSPGAADTPAKRPLAGAQTVPVPVPAHGKAAPRREASQAAAAASLQSRSLAALFDSLRHVPGGADPAGVAEAVPAAGLVRGDAAGSAGGPAVPGARKVPLRARNLPPSFFTEPSRAGGCVCGPSGPGVSLGDLEKGSEAAEFFELLGPDYGAGTEAGALLAAEPLDVFPAGAAVLRGPPELEPGLFDPQPAMVGSLLYPEPWSAPGGPATKKPPLPAPGGGLTLNEPLRSVYPAAADSPGGDDGPGLLASFTPFFSDCALPPAPPPQQVSYDYSAGYSRTAFAGLWRPDGAWEGAPGEEGAPRD", "length": 419, "header": "sp|A7MB34-1|F181B_BOVIN Isoform 1 of Protein FAM181B OS=Bos taurus OX=9913 GN=FAM181B PE=2 SV=1 CANONICAL=A7MB34-1" }, "isoforms": [ { "isoform_ac": "A7MB34-1", "url": "https://www.uniprot.org/uniprotkb/A7MB34/entry#A7MB34-1", "sequence": { "sequence": "MAVQAALLSTHPFVPFGFGGSPDGLGGAFGALEKGCCFEDEETGTPAGALLAGAESGDAREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGAAPPGPSSPGAADTPAKRPLAGAQTVPVPVPAHGKAAPRREASQAAAAASLQSRSLAALFDSLRHVPGGADPAGVAEAVPAAGLVRGDAAGSAGGPAVPGARKVPLRARNLPPSFFTEPSRAGGCVCGPSGPGVSLGDLEKGSEAAEFFELLGPDYGAGTEAGALLAAEPLDVFPAGAAVLRGPPELEPGLFDPQPAMVGSLLYPEPWSAPGGPATKKPPLPAPGGGLTLNEPLRSVYPAAADSPGGDDGPGLLASFTPFFSDCALPPAPPPQQVSYDYSAGYSRTAFAGLWRPDGAWEGAPGEEGAPRD", "length": 419, "header": "sp|A7MB34-1|F181B_BOVIN Isoform 1 of Protein FAM181B OS=Bos taurus OX=9913 GN=FAM181B PE=2 SV=1 CANONICAL=A7MB34-1" }, "locus": { "chromosome": "29", "start_pos": 12926877, "end_pos": 12925621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008954.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008954.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008954.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008954.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613623", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613623", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y254-1", "protein_name": "Family with sequence similarity 181 member B", "gene_name": "FAM181B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVPAALLSPHHLLSFCFPAGGLLGYADLEKGYEGGGGVGGGGGGGGCEAGDFKEATRDLLSFIDSASSNIKLALDKPVKSKRKVNHRKYLQKQIKRCTGIIAPPPAAPPPSACPKPPPPPRREGSQAGSSLQSRSLAALFGSLQPGRGSAGSDGGGAAGGGPRKVPLRDRNLPPSFFTEPGAKETEKGGGPEAAEFFELLGPEYGALLPEHAAPPQDAFPAGRPPAELGLEHGLYEAAPLPAAPHPLLGGLLYPEPPWSPPGPCSPAKKAPPEALRPLYPEPAAGGDAFGPFFPECPLPPPQMPYDYGGGFHRAAYTGL", "length": 320 }, "evidence": [ { "id": "A7MB34", "url": "https://omabrowser.org/oma/group/A7MB34/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A6NEQ2-1", "protein_name": "Protein FAM181B", "gene_name": "FAM181B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVQAALLSTHPFVPFGFGGSPDGLGGAFGALDKGCCFEDDETGAPAGALLSGAEGGDVREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGAAPPGPPSPSAADTPAKRPLAAPSAPTVAAPAHGKAAPRREASQAAAAASLQSRSLAALFDSLRHVPGGAEPAGGEVAAPAAGLGGAGTGGAGGDVAGPAGATAIPGARKVPLRARNLPPSFFTEPSRAGGGGCGPSGPDVSLGDLEKGAEAVEFFELLGPDYGAGTEAAVLLAAEPLDVFPAGASVLRGPPELEPGLFEPPPAVVGNLLYPEPWSVPGCSPTKKSPLTAPRGGLTLNEPLSPLYPAAADSPGGEDGRGHLASFAPFFPDCALPPPPPPHQVSYDYSAGYSRTAYSSLWRSDGVWEGAPGEEGAHRD", "length": 426 }, "evidence": [ { "id": "A7MB34", "url": "https://omabrowser.org/oma/group/A7MB34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B0BN67-1", "protein_name": "Family with sequence similarity 181, member B", "gene_name": "Fam181b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVQAALLSSHPFIPFGFGGSADGLVSAFGSLDKGCCFEDDESAVSAGALLSGSDGGDVREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGTAPPRPPSPSSTDTSAKRPPGAPGASTVATPAHCKAAPRREATQAAAAASLQSRSLAALFDSLRHIPGGAETAGGAVAASVPGLGAASSAGDRAGTSASSVAPGTRKVPLRARNLPPSFFTEPSRVGCCGGGGPSGQGVSLGDLEKGAEAVEFFELLAPDFSTGNDSGVLLAADPLDPFPAGATVLRGPLELESVPFEQPAMVGNLLYPEPWNTPSCPQSKKPPLPGVRGNMTLNEPVRLLYPTALDSPGGEDAPALASFTPFFPDCALPPPHQVSYDYSAGYSRAVYPSLWRPDGVWEGASGEEGAHPD", "length": 419 }, "evidence": [ { "id": "A7MB34", "url": "https://omabrowser.org/oma/group/A7MB34/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1STW2-1", "protein_name": "Family with sequence similarity 181 member B", "gene_name": "FAM181B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVQAALLSTHPFVPFGFGGSPDGLGGAFGALDKGCCFEDEETGTPAGALLAGAEGGDVREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGAAPPCPPSPGATDTPAKRPLAAAGAQTVAVATHGKAAPRREASQAAAAASLQSRSLAALFDSLRHVPGGAESAGAAVAATAGGLGGAGAGGSGGDAAGTAGCPVVPGARKVPLRARNLPPSFFTEPSRAVSGGCGPSGPGVSLGDLEKGAEAVEFFELLGPDYCQGTEAGVLLAAEPLDVFPTGAAVVRGSPELEPGLFEPPPAMVGSLLYPEPWSAPGCPAPKKPPLAAPRGGLTLNEPLRPLYPAAPDSPGGEDGPGLLASFAPFFSDCALPPPPPQQVSYEYSAGYSRSAYSSLWRPDGVWEGAPGEEEAPRD", "length": 425 }, "evidence": [ { "id": "A7MB34", "url": "https://omabrowser.org/oma/group/A7MB34/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80VF6-1", "protein_name": "Protein FAM181B", "gene_name": "Fam181b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVQAALLSSHPFIPFGFGGSADGLVSAFGSLDKGCCFEDDESGASAGALLSGSEGGDVREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIKRCSGLMGTAPPRPASPSAADAPAKRPPGAPTVATPAHCKAAPRREATQAAAAASLQSRSLAALFDSLRHIPGGAETAGGAEAVSVPGLGAASAVGDGAGTAVSSVAPGTRKVPLRARNLPPSFFTEPSRVGCGGASGVPSGQGVSLGDLEKGAEAVEFFELLAPDFGSGNDSGVLMAADPLDPFPAGATVLRGPLELESGPFEQPAMVGNLLYPEPWNTPSCPQTKKPPVAGVRGGVTLNEPVRLLYPTALDSPGGEDAPALSSFTPFFPDCALPPPHQVSYDYSAGYSRAVYPSLWRPDGVWEGASGEEGGHPD", "length": 417 }, "evidence": [ { "id": "A7MB34", "url": "https://omabrowser.org/oma/group/A7MB34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 419, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB34" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A7YVI8-1", "uniprot_ac": "A7YVI8", "uniprot_id": "OXLD1_BOVIN", "mass": { "chemical_mass": 16256.0, "monoisotopic_mass": 16256.0 }, "refseq": { "ac": "NP_001099105", "name": "oxidoreductase-like domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099105" }, "gene_names": [ { "name": "OXLD1", "type": "recommended", "evidence": [ { "id": "A7YVI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YVI8" } ] }, { "name": "C19H17orf90", "type": "synonym", "evidence": [ { "id": "NP_001099105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099105" } ] }, { "name": "OXLD1", "type": "synonym", "evidence": [ { "id": "NP_001099105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099105" } ] } ], "protein_names": [ { "name": "Oxidoreductase-like domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A7YVI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YVI8/entry#names_and_taxonomy" } ] }, { "name": "oxidoreductase-like domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001099105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099105" } ] }, { "name": "uncharacterized protein C17orf90 homolog", "type": "synonym", "evidence": [ { "id": "NP_001099105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099105" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YVI8", "url": "https://www.uniprot.org/uniprotkb/A7YVI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OXLD1", "url": "https://www.uniprot.org/uniprotkb/A7YVI8", "locus": { "chromosome": "19", "start_pos": 51156611, "end_pos": 51153830, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000355", "url": "https://www.ensembl.org/id/ENSBTAG00000000355" } ] } } ], "crossref": [ { "id": "A7YVI8", "url": "https://alphafold.ebi.ac.uk/entry/A7YVI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617776", "url": "https://www.ncbi.nlm.nih.gov/gene/617776", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617776", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617776", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RKFGKDH", "url": "https://omabrowser.org/oma/group/RKFGKDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7YVI8", "url": "https://www.orthodb.org/?gene=A7YVI8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21193", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21193", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21193:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21193:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001099105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099105", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7YVI8", "url": "https://www.uniprot.org/uniprotkb/A7YVI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YVI8-1", "url": "https://www.uniprot.org/uniprotkb/A7YVI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLRRVTGGGRAVVAATLGGGPLSSWDWCQKLPGGGSLLRRIQVREAHREFGKNHVEVGSQAGAAGTGQPKSSLQGGGPSGPLYPPPPELQPPTNCCMSGCPNCVWVEYADALLQHYQDGGERALAALEEHVTDENLKAFLRMEIQLRIRSGG", "length": 153, "header": "sp|A7YVI8-1|OXLD1_BOVIN Isoform 1 of Oxidoreductase-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=OXLD1 PE=2 SV=1 CANONICAL=A7YVI8-1" }, "isoforms": [ { "isoform_ac": "A7YVI8-1", "url": "https://www.uniprot.org/uniprotkb/A7YVI8/entry#A7YVI8-1", "sequence": { "sequence": "MLLRRVTGGGRAVVAATLGGGPLSSWDWCQKLPGGGSLLRRIQVREAHREFGKNHVEVGSQAGAAGTGQPKSSLQGGGPSGPLYPPPPELQPPTNCCMSGCPNCVWVEYADALLQHYQDGGERALAALEEHVTDENLKAFLRMEIQLRIRSGG", "length": 153, "header": "sp|A7YVI8-1|OXLD1_BOVIN Isoform 1 of Oxidoreductase-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=OXLD1 PE=2 SV=1 CANONICAL=A7YVI8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617776", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617776", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BPZ9-1", "protein_name": "Oxidoreductase like domain containing 1", "gene_name": "OXLD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLRSVAGGCWVAAAARSRVLLSSWDRCQRLPGDSSILHRTRGFGGHRGFGKDHEEVETRAGATDPGQPKSSLPGGRPSESPYPPPPELQPPTNCCMSGCPNCVWVEYADALLRHYQDGGQRALAALEEHVADETLKAFLRVEIQLRLKSGG", "length": 152 }, "evidence": [ { "id": "A7YVI8", "url": "https://omabrowser.org/oma/group/A7YVI8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5BKU9-1", "protein_name": "Oxidoreductase-like domain-containing protein 1", "gene_name": "OXLD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLRRVVEGGRAVAAAVRGSGARRFSSPDCCQRLPGGGSFLQRHHPGAQAPDGRRKFGTDHVEVGSQAGADGTRPPKASLPPELQPPTNCCMSGCPNCVWVEYADRLLQHFQDGGERALAALEEHVADENLKAFLRMEIRLHTRCGG", "length": 147 }, "evidence": [ { "id": "A7YVI8", "url": "https://omabrowser.org/oma/group/A7YVI8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YVI8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YVI8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YVI8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A8NIX5-1", "uniprot_ac": "A8NIX5", "uniprot_id": "CB081_BOVIN", "mass": { "chemical_mass": 54734.0, "monoisotopic_mass": 54734.0 }, "refseq": { "ac": "NP_001103658", "name": "uncharacterized protein C2orf81 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103658" }, "gene_names": [ { "name": "C11H2orf81", "type": "synonym", "evidence": [ { "id": "NP_001103658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103658" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C2orf81 homolog", "type": "recommended", "evidence": [ { "id": "A8NIX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8NIX5/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C2orf81 homolog", "type": "synonym", "evidence": [ { "id": "NP_001103658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103658" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8NIX5", "url": "https://www.uniprot.org/uniprotkb/A8NIX5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A8NIX5", "locus": {} } ], "crossref": [ { "id": "A8NIX5", "url": "https://alphafold.ebi.ac.uk/entry/A8NIX5", "database": "AlphaFoldDB", "categories": [] }, { "id": "789060", "url": "https://www.ncbi.nlm.nih.gov/gene/789060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789060", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A8NIX5", "url": "https://www.orthodb.org/?gene=A8NIX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34438", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34438", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34438:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34438:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15479", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15479", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001103658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103658", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8NIX5", "url": "https://www.uniprot.org/uniprotkb/A8NIX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8NIX5-1", "url": "https://www.uniprot.org/uniprotkb/A8NIX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHEGPRQVRDRGMTRSKAEKVRPPTVPVPQVDIVPGRLTEAEWIAFTALEEGEDVVGDILADLVARVIDSAFKVYLTQQCIPFTISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHARASMGLEETFQGEDQDSVDQIPLGGSWKDSGSQEPMESWELTVTPDSPPTPELLQETGPRSPLEKLGDQSRSDQTDLFAVGSSNSSSQLSMEMVPAGSTHASLELSLVASPQASVERAQPISSQFSLEDLYNCTPQPHAAGDRLELREEKVPLIPSRVLVSDPSAGGPTTLNPSAGFQPQPPWLAEERPSALHSRIGRMGTTARLDPARLPRPDMARSPSPKLWPGAKWPSGWEGEAELLGELWAGRTRVPPQGLDLGDRESQDPHQYRHPVPQVLEATSQVTWKPVLLPGALKLAPGVSMWNPSTQVLLSSSEPQRNDREGSASPPIHTGAPKPQVTVAQLMNSALKMWSLPSKRLPNSKP", "length": 503, "header": "sp|A8NIX5-1|CB081_BOVIN Isoform 1 of Uncharacterized protein C2orf81 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A8NIX5-1" }, "isoforms": [ { "isoform_ac": "A8NIX5-1", "url": "https://www.uniprot.org/uniprotkb/A8NIX5/entry#A8NIX5-1", "sequence": { "sequence": "MAHEGPRQVRDRGMTRSKAEKVRPPTVPVPQVDIVPGRLTEAEWIAFTALEEGEDVVGDILADLVARVIDSAFKVYLTQQCIPFTISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHARASMGLEETFQGEDQDSVDQIPLGGSWKDSGSQEPMESWELTVTPDSPPTPELLQETGPRSPLEKLGDQSRSDQTDLFAVGSSNSSSQLSMEMVPAGSTHASLELSLVASPQASVERAQPISSQFSLEDLYNCTPQPHAAGDRLELREEKVPLIPSRVLVSDPSAGGPTTLNPSAGFQPQPPWLAEERPSALHSRIGRMGTTARLDPARLPRPDMARSPSPKLWPGAKWPSGWEGEAELLGELWAGRTRVPPQGLDLGDRESQDPHQYRHPVPQVLEATSQVTWKPVLLPGALKLAPGVSMWNPSTQVLLSSSEPQRNDREGSASPPIHTGAPKPQVTVAQLMNSALKMWSLPSKRLPNSKP", "length": 503, "header": "sp|A8NIX5-1|CB081_BOVIN Isoform 1 of Uncharacterized protein C2orf81 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A8NIX5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 116, "start_aa": "Thr", "end_pos": 116, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr116", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 191, "start_aa": "Thr", "end_pos": 191, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr191", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [ { "start_pos": 239, "end_pos": 239, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A8NIX5", "url": "https://www.uniprot.org/uniprotkb/A8NIX5" } ], "site_lbl": "Ser239" }, { "start_pos": 243, "end_pos": 243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A8NIX5", "url": "https://www.uniprot.org/uniprotkb/A8NIX5" } ], "site_lbl": "Ser243" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:789060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789060", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A8NIX5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 503, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A8NIX5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A8NIX5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 116, 191 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 239, 243 ], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 273, "end_pos": 275 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A8WFF7-1", "uniprot_ac": "A8WFF7", "uniprot_id": "CK091_BOVIN", "mass": { "chemical_mass": 20404.0, "monoisotopic_mass": 20404.0 }, "refseq": { "ac": "NP_001103655", "name": "uncharacterized protein C11orf91 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103655" }, "gene_names": [ { "name": "C15H11orf91", "type": "synonym", "evidence": [ { "id": "NP_001103655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103655" } ] } ], "protein_names": [ { "name": "Uncharacterized protein C11orf91 homolog", "type": "recommended", "evidence": [ { "id": "A8WFF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8WFF7/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C11orf91 homolog", "type": "synonym", "evidence": [ { "id": "NP_001103655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103655" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8WFF7", "url": "https://www.uniprot.org/uniprotkb/A8WFF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A8WFF7", "locus": {} } ], "crossref": [ { "id": "A8WFF7", "url": "https://alphafold.ebi.ac.uk/entry/A8WFF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027577", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027577", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781657", "url": "https://www.ncbi.nlm.nih.gov/gene/781657", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781657", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781657", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCCPPPW", "url": "https://omabrowser.org/oma/group/RCCPPPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A8WFF7", "url": "https://www.orthodb.org/?gene=A8WFF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36288:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36288:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001103655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103655", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8WFF7", "url": "https://www.uniprot.org/uniprotkb/A8WFF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8WFF7-1", "url": "https://www.uniprot.org/uniprotkb/A8WFF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKGRRGSQSPTMSQRPAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGGAPAGGAPAAGGRSLPQGPSAPAPPPPPGLGPPSERPCPPPWPSGLASIPYEPLRFFYSPPSGPEAAASPLAPGPMTSRLASASHPEELCELEIRIKELELLTITGDGFDSQRYKFLKALKDEKLQGLKTRQPGKKSASLS", "length": 193, "header": "sp|A8WFF7-1|CK091_BOVIN Isoform 1 of Uncharacterized protein C11orf91 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A8WFF7-1" }, "isoforms": [ { "isoform_ac": "A8WFF7-1", "url": "https://www.uniprot.org/uniprotkb/A8WFF7/entry#A8WFF7-1", "sequence": { "sequence": "MPKGRRGSQSPTMSQRPAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGGAPAGGAPAAGGRSLPQGPSAPAPPPPPGLGPPSERPCPPPWPSGLASIPYEPLRFFYSPPSGPEAAASPLAPGPMTSRLASASHPEELCELEIRIKELELLTITGDGFDSQRYKFLKALKDEKLQGLKTRQPGKKSASLS", "length": 193, "header": "sp|A8WFF7-1|CK091_BOVIN Isoform 1 of Uncharacterized protein C11orf91 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=A8WFF7-1" }, "locus": { "chromosome": "15", "start_pos": 64334444, "end_pos": 64332675, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039684.4", "url": "https://www.ensembl.org/id/ENSBTAT00000039684.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039473.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039473.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781657", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781657", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A0Z9-1", "protein_name": "Similar to human chromosome 11 open reading frame 91", "gene_name": "C3h11orf91", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGRRGSQNPKMSQRPAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGGTPSAGVAGVAGVRPLPLAPPATVPPPPPGLGPPSERPCPPPWPSGLASIPYEPLRFFYSPPPGPEMATSALVPGSTTPWLASASHPEELCELEIRIKELELLTITGDGFDSQRYKFLKALKDEKLQGLKTTRQPGKSASFS", "length": 194 }, "evidence": [ { "id": "A8WFF7", "url": "https://omabrowser.org/oma/group/A8WFF7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SGR5-1", "protein_name": "Chromosome 2 C11orf91 homolog", "gene_name": "C11orf91", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKGRRGSQSPRMSQRPAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGAGPAGGAAGARPLPQTPLVSAPPPPPPPPPPPGLGPRSERSCPPPWPSGLASIPYEPLRFFYSPPPGPEVAASSLAPGPTTPRLASASHPEELCELEIRIKELELLTITGDGFDSQRYKFLKALKDEKLQGLKTRPPGKKSASLS", "length": 197 }, "evidence": [ { "id": "A8WFF7", "url": "https://omabrowser.org/oma/group/A8WFF7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3C1V1-1", "protein_name": "Uncharacterized protein C11orf91", "gene_name": "C11orf91", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKGRRGSHSPTMSQRSAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGGAPVGGAAGARSLSQALPAPAPPPPPPPGLGPSSERPWPSPWPSGLASIPYEPLRFFYSPPPGPEVVASPLVPCPSTPRLASASHPEELCELEIRIKELELLTITGDGFDSQSYTFLKALKDEKLQGLKTKQPGKKSASLS", "length": 193 }, "evidence": [ { "id": "A8WFF7", "url": "https://omabrowser.org/oma/group/A8WFF7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D1Z2-1", "protein_name": "Uncharacterized protein C11orf91 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKGRRGSQNPKMSQRPAPPLYFPSLYDRGISSSPLSDFNIWKKLFVPLKAGGTPAAGVAGVAGVRSLPLAPPATVPPPPPGLGPPSERPCPPPWPSGLASIPYEPLRFFYSPPPGPEMATSALVPGSTTPWLASASHPEELCELEIRIKELELLTITGDGFDSQRYKFLKALKDEKLQGLKMSRQPGKSASCS", "length": 194 }, "evidence": [ { "id": "A8WFF7", "url": "https://omabrowser.org/oma/group/A8WFF7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A8WFF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 193, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A8WFF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A8WFF7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B6Y8-1", "uniprot_ac": "E1B6Y8", "uniprot_id": "E1B6Y8_BOVIN", "mass": { "chemical_mass": 20565.0, "monoisotopic_mass": 20565.0 }, "refseq": { "ac": "XP_059733526", "name": "p53 apoptosis effector related to PMP-22-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733526" }, "gene_names": [ { "name": "LOC101906045", "type": "recommended", "evidence": [ { "id": "E1B6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ] }, { "name": "LOC101906045", "type": "synonym", "evidence": [ { "id": "XP_059733526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733526" } ] } ], "protein_names": [ { "name": "p53 apoptosis effector related to PMP-22", "type": "recommended", "evidence": [ { "id": "E1B6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8/entry#names_and_taxonomy" } ] }, { "name": "Keratinocyte-associated protein 1", "type": "synonym", "evidence": [ { "id": "E1B6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8/entry#names_and_taxonomy" } ] }, { "name": "p53 apoptosis effector related to PMP-22-like", "type": "synonym", "evidence": [ { "id": "XP_059733526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733526" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101906045", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8", "locus": {} } ], "crossref": [ { "id": "E1B6Y8", "url": "https://alphafold.ebi.ac.uk/entry/E1B6Y8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001350", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001350", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101906045", "url": "https://www.ncbi.nlm.nih.gov/gene/101906045", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015664", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015664", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101906045", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906045", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTYFYSS", "url": "https://omabrowser.org/oma/group/PTYFYSS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14399:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14399:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_059733526", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733526", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Y8-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRCGLACERCRWILPLLLLSAIVFDIIALAGRGWLQSSDDSQTSSLWWHCLLEVCDSLMTYAWGRAAAAMLLCGFIILVICFILSFFALCGPQMLAFLRVIRGLLALAAVFQIISLVIYPVKYTQTFNLHLNPAVTYIYNWAYGFGWAATIILIGCAFFCCLPNYEDDLLGNAKPRYFYTSA", "length": 183, "header": "tr|E1B6Y8-1|E1B6Y8_BOVIN Isoform 1 of p53 apoptosis effector related to PMP-22 OS=Bos taurus OX=9913 GN=LOC101906045 PE=3 SV=2 CANONICAL=E1B6Y8-1" }, "isoforms": [ { "isoform_ac": "E1B6Y8-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8/entry", "sequence": { "sequence": "MLRCGLACERCRWILPLLLLSAIVFDIIALAGRGWLQSSDDSQTSSLWWHCLLEVCDSLMTYAWGRAAAAMLLCGFIILVICFILSFFALCGPQMLAFLRVIRGLLALAAVFQIISLVIYPVKYTQTFNLHLNPAVTYIYNWAYGFGWAATIILIGCAFFCCLPNYEDDLLGNAKPRYFYTSA", "length": 183, "header": "tr|E1B6Y8-1|E1B6Y8_BOVIN Isoform 1 of p53 apoptosis effector related to PMP-22 OS=Bos taurus OX=9913 GN=LOC101906045 PE=3 SV=2 CANONICAL=E1B6Y8-1" }, "locus": { "chromosome": "18", "start_pos": 50067762, "end_pos": 50067754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001777.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001777.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049991.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049991.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101906045", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906045", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y8", "url": "https://www.uniprot.org/uniprotkb/E1B6Y8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B6Y8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 183, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B6Y8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B6Y8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B722-1", "uniprot_ac": "E1B722", "uniprot_id": "E1B722_BOVIN", "mass": { "chemical_mass": 34128.0, "monoisotopic_mass": 34128.0 }, "refseq": { "ac": "XP_005201837", "name": "protein C3orf33 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201837" }, "gene_names": [ { "name": "C1H3orf33", "type": "recommended", "evidence": [ { "id": "E1B722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B722" } ] }, { "name": "C1H3orf33", "type": "synonym", "evidence": [ { "id": "XP_005201837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201837" } ] } ], "protein_names": [ { "name": "Chromosome 1 C3orf33 homolog", "type": "synonym", "evidence": [ { "id": "E1B722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B722/entry#names_and_taxonomy" } ] }, { "name": "protein C3orf33 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201837" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B722", "url": "https://www.uniprot.org/uniprotkb/E1B722" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1H3orf33", "url": "https://www.uniprot.org/uniprotkb/E1B722", "locus": { "chromosome": "1", "start_pos": 111902823, "end_pos": 111876289, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005203", "url": "https://www.ensembl.org/id/ENSBTAG00000005203" } ] } } ], "crossref": [ { "id": "E1B722", "url": "https://alphafold.ebi.ac.uk/entry/E1B722", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005203", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005203", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507040", "url": "https://www.ncbi.nlm.nih.gov/gene/507040", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR035437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ETWKENM", "url": "https://omabrowser.org/oma/group/ETWKENM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B722", "url": "https://www.orthodb.org/?gene=E1B722", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28434", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28434", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28434:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28434:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005201837", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201837", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B722", "url": "https://www.uniprot.org/uniprotkb/E1B722", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B722-1", "url": "https://www.uniprot.org/uniprotkb/E1B722-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGQPATPATPPPNRDGAAPNVVARISQWADDHLRLVRNISTVMAMAGVMLLLRSVRLTSKFTRSSDIPVEFIRKNVKLRGRLHRITENGLEIEHIPIALPAISSWRKEPCGVLLIKLAGVELTETGKVWLQKELKPSQVLWFQLLGKENSALFCYLLVNKGRFFSVNLNEEILRRGLGKTVLVKGLSHDSKIYWRIHRNLLKAELTALKKGEGVWKEDSEKESYLEKLKGSWREIWKKDSYFKKNGSDFNLKKESYYDKFKRSYETWKETVNNYSLILKFRELMSRIHFRRKE", "length": 294, "header": "tr|E1B722-1|E1B722_BOVIN Isoform 1 of Chromosome 1 C3orf33 homolog OS=Bos taurus OX=9913 GN=C1H3orf33 PE=4 SV=1 CANONICAL=E1B722-1" }, "isoforms": [ { "isoform_ac": "E1B722-1", "url": "https://www.uniprot.org/uniprotkb/E1B722/entry", "sequence": { "sequence": "MAGQPATPATPPPNRDGAAPNVVARISQWADDHLRLVRNISTVMAMAGVMLLLRSVRLTSKFTRSSDIPVEFIRKNVKLRGRLHRITENGLEIEHIPIALPAISSWRKEPCGVLLIKLAGVELTETGKVWLQKELKPSQVLWFQLLGKENSALFCYLLVNKGRFFSVNLNEEILRRGLGKTVLVKGLSHDSKIYWRIHRNLLKAELTALKKGEGVWKEDSEKESYLEKLKGSWREIWKKDSYFKKNGSDFNLKKESYYDKFKRSYETWKETVNNYSLILKFRELMSRIHFRRKE", "length": 294, "header": "tr|E1B722-1|E1B722_BOVIN Isoform 1 of Chromosome 1 C3orf33 homolog OS=Bos taurus OX=9913 GN=C1H3orf33 PE=4 SV=1 CANONICAL=E1B722-1" }, "locus": { "chromosome": "1", "start_pos": 111901819, "end_pos": 111876393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006854.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006854.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006854.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006854.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 10, "start_aa": "Thr", "end_pos": 10, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr10", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 7, "start_aa": "Thr", "end_pos": 7, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr7", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K3F1-1", "protein_name": "Similar to human chromosome 3 open reading frame 33", "gene_name": "C2h3orf33", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPLPASLGSQASDRDRGEANVVTRMSQWADNHLRLVQNISTGMAIAGIVLLIRSVRLTSKFTTSSDIPVEFIRKKVKLRGRLQRITECGLEIEHVPITLPFISSWKQEPCGVLLVKLAGVELTEAGKVWLQKELRPSQLLWFQLLGKENSELFCYLLVNKGGYFNVNLNEEILRRGLGKTVLVKGLNYDSKTHWKIHRKLLKAELTALKKGEGIWKEESEKESYFRKLKDSWRERWTKDNDLKTAGPGLSATKEGHYDRFRRAYGSWKDNMGNYSLVLKLREFVSRLHFRRKG", "length": 294 }, "evidence": [ { "id": "E1B722", "url": "https://omabrowser.org/oma/group/E1B722/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B8JLW4-1", "protein_name": "Protein C3orf33 homolog", "gene_name": "c18h3orf33", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPSVPADNTDDAKPSKNFVALLSNFADDHLTVVRSISTCIGLAGLLIVARSIRLMTKFGSGTDIPARFIERNIIIRGRLRNITEKGLEVEHIPISVPLLSRLLAKRQTEALLDVRLAGVELTSEGHHWIGQQLRPAETVWLRLIARQNETLHCLVSVNKGSLFNTCVNEELLRLGLARTSPLVVLDPHSQIYWSLYKRLLRAESKAEKKGKGLWKEESRWERFTDVLRNNMLLVSLKKLFKWRSGTKEK", "length": 249 }, "evidence": [ { "id": "E1B722", "url": "https://omabrowser.org/oma/group/E1B722/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P1S2-1", "protein_name": "Mitochondrial inner membrane subdomain organizer 1", "gene_name": "MISO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGQPAATGSPSADKDGMEPNVVARISQWADDHLRLVRNISTGMAIAGIMLLLRSIRLTSKFTSSSDIPVEFIRRNVKLRGRLRRITENGLEIEHIPITLPIIASLRKEPRGALLVKLAGVELAETGKAWLQKELKPSQLLWFQLLGKENSALFCYLLVSKGGYFSVNLNEEILRRGLGKTVLVKGLKYDSKIYWTVHRNLLKAELTALKKGEGIWKEDSEKESYLEKFKDSWREIWKKDSFLKTTGSDFSLKKESYYEKLKRTYEIWKDNMNNCSLILKFRELISRINFRRKG", "length": 294 }, "evidence": [ { "id": "E1B722", "url": "https://omabrowser.org/oma/group/E1B722/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BN57-1", "protein_name": "Mitochondrial inner membrane subdomain organizer 1", "gene_name": "Miso1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARPPASLGSQAPDRDRGEANVVTRVSQWADNHLRLVQNISTGMAIAGIMLLIRSVRLTSKFTTSSDIPVEFIRKKVKLRGRLQRITECGLEIEHIPITLPFISSWKEEPRGVLLVKLAGVELTESGKVWLQAELKPSQLLWFQLLGKEDSALFCYLLVNKGGYFNVNLNEEILRRGLGKTVLVKGLNYDSKTHWKIHRNLLKAELTALKKGEGIWKEESEKESYFRKLKDSWRERWTKDNDLKPAGADLGSTKDSYHDSRRRASGKGKDSVSNYSFFLKLREFVSRLHFWRKG", "length": 294 }, "evidence": [ { "id": "E1B722", "url": "https://omabrowser.org/oma/group/E1B722/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B722", "url": "https://www.uniprot.org/uniprotkb/E1B722" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B722", "url": "https://www.uniprot.org/uniprotkb/E1B722" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of ERK1 and ERK2 cascade", "id": "GO:0070373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373", "evidence": [ { "database": "UniProtKB", "id": "E1B722", "url": "https://www.uniprot.org/uniprotkb/E1B722" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B722-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 294, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B722-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B722" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 7, 10 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 246, "end_pos": 248 }, { "start_pos": 274, "end_pos": 276 }, { "start_pos": 39, "end_pos": 41 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B746-1", "uniprot_ac": "E1B746", "uniprot_id": "E1B746_BOVIN", "mass": { "chemical_mass": 25867.0, "monoisotopic_mass": 25867.0 }, "refseq": { "ac": "XP_010802039", "name": "leucine rich adaptor protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802039" }, "gene_names": [ { "name": "LURAP1", "type": "recommended", "evidence": [ { "id": "E1B746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B746" } ] }, { "name": "LURAP1", "type": "synonym", "evidence": [ { "id": "XP_010802039", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802039" } ] } ], "protein_names": [ { "name": "Leucine rich adaptor protein 1", "type": "synonym", "evidence": [ { "id": "E1B746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B746/entry#names_and_taxonomy" } ] }, { "name": "leucine rich adaptor protein 1", "type": "synonym", "evidence": [ { "id": "XP_010802039", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802039" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B746", "url": "https://www.uniprot.org/uniprotkb/E1B746" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LURAP1", "url": "https://www.uniprot.org/uniprotkb/E1B746", "locus": { "chromosome": "3", "start_pos": 99869306, "end_pos": 99881275, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024144", "url": "https://www.ensembl.org/id/ENSBTAG00000024144" } ] } } ], "crossref": [ { "id": "E1B746", "url": "https://alphafold.ebi.ac.uk/entry/E1B746", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024144", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024144", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785028", "url": "https://www.ncbi.nlm.nih.gov/gene/785028", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785028", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785028", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCPEMDW", "url": "https://omabrowser.org/oma/group/PCPEMDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR33767", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33767", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33767:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33767:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14854", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14854", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010802039", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802039", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B746", "url": "https://www.uniprot.org/uniprotkb/E1B746", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B746-1", "url": "https://www.uniprot.org/uniprotkb/E1B746-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGEWEPGTSEAVLLSGAPSTGHSLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVAPSELDEHGPPGAPRPEMDWAKVIPGGERARTEVDLTATRLGSLRAVWKPPGEGLQGASPEPPEDESAKLGFETHWYWGQCQDDVTFL", "length": 239, "header": "tr|E1B746-1|E1B746_BOVIN Isoform 1 of Leucine rich adaptor protein 1 OS=Bos taurus OX=9913 GN=LURAP1 PE=4 SV=1 CANONICAL=E1B746-1" }, "isoforms": [ { "isoform_ac": "E1B746-1", "url": "https://www.uniprot.org/uniprotkb/E1B746/entry", "sequence": { "sequence": "MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGEWEPGTSEAVLLSGAPSTGHSLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVAPSELDEHGPPGAPRPEMDWAKVIPGGERARTEVDLTATRLGSLRAVWKPPGEGLQGASPEPPEDESAKLGFETHWYWGQCQDDVTFL", "length": 239, "header": "tr|E1B746-1|E1B746_BOVIN Isoform 1 of Leucine rich adaptor protein 1 OS=Bos taurus OX=9913 GN=LURAP1 PE=4 SV=1 CANONICAL=E1B746-1" }, "locus": { "chromosome": "3", "start_pos": 99881087, "end_pos": 99870310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033319.3", "url": "https://www.ensembl.org/id/ENSBTAT00000033319.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000033234.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785028", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785028", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S3V1-1", "protein_name": "Leucine rich adaptor protein 1", "gene_name": "LURAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGEWEPGTSGALLLPGAPSTGHGLGDKIMALRTELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDASSTDRLDSVSIGSFLDTVAPSELDEQGPPGAPRPEMDWAKVIPTGERARTELDLTAARLGSLRALWKPPGEGLQGGPPEPPEDESAKLGFEAHWYWGQCQDDVTFL", "length": 239 }, "evidence": [ { "id": "E1B746", "url": "https://omabrowser.org/oma/group/E1B746/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96LR2-1", "protein_name": "Leucine rich adaptor protein 1", "gene_name": "LURAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGTVESQTPDLRDVEGKVGRKTPEGLLRGLRGECELGTSGALLLPGASSTGHDLGDKIMALKMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSTTDRLDSVSIGSFLDTVAPSELDEQGPPGAPRSEMDWAKVIAGGERARTEVDVAATRLGSLRAVWKPPGERLQGGPPESPEDESAKLGFEAHWFWEQCQDDVTFL", "length": 239 }, "evidence": [ { "id": "E1B746", "url": "https://omabrowser.org/oma/group/E1B746/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D6I9-1", "protein_name": "Leucine rich adaptor protein 1", "gene_name": "Lurap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGTAESQTPDLRDVEGKVGRKIPEGLLRGLRGECELGTSGDVLLPGAPSTGHGLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVTPRELDEQGLPGPSCPEIDWAKVIPTEDRARTEVDMTSTKLGSLTATWKLPGDGLQCGPPEPSEDGNANQGFEAHWYWGQCQDDVTFL", "length": 239 }, "evidence": [ { "id": "E1B746", "url": "https://omabrowser.org/oma/group/E1B746/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B746", "url": "https://www.uniprot.org/uniprotkb/E1B746" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "E1B746", "url": "https://www.uniprot.org/uniprotkb/E1B746" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "E1B746", "url": "https://www.uniprot.org/uniprotkb/E1B746" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B746-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 239, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B746-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B746" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B773-1", "uniprot_ac": "E1B773", "uniprot_id": "E1B773_BOVIN", "mass": { "chemical_mass": 11766.0, "monoisotopic_mass": 11766.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Glutaredoxin-1", "type": "recommended", "evidence": [ { "id": "E1B773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B773/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.", "evidence": [ { "database": "UniProtKB", "id": "E1B773", "url": "https://www.uniprot.org/uniprotkb/E1B773#function" }, { "database": "UniProtKB", "id": "ARBA00002549", "url": "https://www.uniprot.org/uniprotkb/ARBA00002549#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B773", "url": "https://www.uniprot.org/uniprotkb/E1B773" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B773", "locus": {} } ], "crossref": [ { "id": "E1B773", "url": "https://alphafold.ebi.ac.uk/entry/E1B773", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031256", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031256", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03419", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03419", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DAMEWID", "url": "https://omabrowser.org/oma/group/DAMEWID/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46185:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46185:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B773", "url": "https://www.uniprot.org/uniprotkb/E1B773", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B773-1", "url": "https://www.uniprot.org/uniprotkb/E1B773-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQAFVNSKIQPGKVVVFIKPTCPYCRKTQELLSQLPFKQGLLEFVGITAAGNTSEIQDYLQQLTRARTVPQVFIGQECIGGCTDLVNMHERGELLTRLKQIGALQ", "length": 106, "header": "tr|E1B773-1|E1B773_BOVIN Isoform 1 of Glutaredoxin-1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1B773-1" }, "isoforms": [ { "isoform_ac": "E1B773-1", "url": "https://www.uniprot.org/uniprotkb/E1B773/entry", "sequence": { "sequence": "MAQAFVNSKIQPGKVVVFIKPTCPYCRKTQELLSQLPFKQGLLEFVGITAAGNTSEIQDYLQQLTRARTVPQVFIGQECIGGCTDLVNMHERGELLTRLKQIGALQ", "length": 106, "header": "tr|E1B773-1|E1B773_BOVIN Isoform 1 of Glutaredoxin-1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1B773-1" }, "locus": { "chromosome": "X", "start_pos": 126278565, "end_pos": 126278248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044267.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044267.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052392.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052392.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TW40-1", "protein_name": "Glutaredoxin domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "IAQAFVNSKIQPGKVVVFIKPTCPFYRKTQDLLSQLPFKEGLLEFVNITATSYTNEIQDYLQLLTGARTVPQVFISKECIGGCTDLVSMHERGELLTRLEQTGALK", "length": 106 }, "evidence": [ { "id": "E1B773", "url": "https://omabrowser.org/oma/group/E1B773/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glutathione disulfide oxidoreductase activity", "id": "GO:0015038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015038", "evidence": [ { "database": "UniProtKB", "id": "E1B773", "url": "https://www.uniprot.org/uniprotkb/E1B773" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B773-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 106, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B773-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B773" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B773" }, { "id": "PF00462", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glutaredoxin", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 80, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 53, "end_pos": 55 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B780-1", "uniprot_ac": "E1B780", "uniprot_id": "E1B780_BOVIN", "mass": { "chemical_mass": 14086.0, "monoisotopic_mass": 14086.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1B780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B780/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B780", "url": "https://www.uniprot.org/uniprotkb/E1B780" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B780", "locus": {} } ], "crossref": [ { "id": "E1B780", "url": "https://alphafold.ebi.ac.uk/entry/E1B780", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000055254", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000055254", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B780", "url": "https://www.uniprot.org/uniprotkb/E1B780", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B780-1", "url": "https://www.uniprot.org/uniprotkb/E1B780-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRAPVLLLVFLALVTQVSSNMEGDKMSITRATGSSAVIPCDLPTQNKQYIHWYKFQEGTVPRRLLYYDVSYSKVVLESGISPGKYHGYEGTDKMYKFVISNLQESDSGVYRCAVWEKHIGSALL", "length": 125, "header": "tr|E1B780-1|E1B780_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B780-1" }, "isoforms": [ { "isoform_ac": "E1B780-1", "url": "https://www.uniprot.org/uniprotkb/E1B780/entry", "sequence": { "sequence": "MLRAPVLLLVFLALVTQVSSNMEGDKMSITRATGSSAVIPCDLPTQNKQYIHWYKFQEGTVPRRLLYYDVSYSKVVLESGISPGKYHGYEGTDKMYKFVISNLQESDSGVYRCAVWEKHIGSALL", "length": 125, "header": "tr|E1B780-1|E1B780_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B780-1" }, "locus": { "chromosome": "4", "start_pos": 82699796, "end_pos": 82692892, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013603.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013603.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013603.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013603.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "E1B780", "url": "https://www.uniprot.org/uniprotkb/E1B780" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "E1B780", "url": "https://www.uniprot.org/uniprotkb/E1B780" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B780-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B780-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B780" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B780" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 125, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B791-1", "uniprot_ac": "E1B791", "uniprot_id": "E1B791_BOVIN", "mass": { "chemical_mass": 16355.0, "monoisotopic_mass": 16355.0 }, "refseq": { "ac": "XP_010809610", "name": "cystatin-13 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809610" }, "gene_names": [ { "name": "LOC531692", "type": "recommended", "evidence": [ { "id": "E1B791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B791" } ] }, { "name": "LOC531692", "type": "synonym", "evidence": [ { "id": "XP_010809610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809610" } ] } ], "protein_names": [ { "name": "Cystatin domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1B791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B791/entry#names_and_taxonomy" } ] }, { "name": "cystatin-13 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010809610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809610" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B791", "url": "https://www.uniprot.org/uniprotkb/E1B791" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC531692", "url": "https://www.uniprot.org/uniprotkb/E1B791", "locus": {} } ], "crossref": [ { "id": "E1B791", "url": "https://alphafold.ebi.ac.uk/entry/E1B791", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015949", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015949", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531692", "url": "https://www.ncbi.nlm.nih.gov/gene/531692", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531692", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531692", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETYVYVQ", "url": "https://omabrowser.org/oma/group/ETYVYVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B791", "url": "https://www.orthodb.org/?gene=E1B791", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47010", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47010", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47010:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47010:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010809610", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809610", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B791", "url": "https://www.uniprot.org/uniprotkb/E1B791", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B791-1", "url": "https://www.uniprot.org/uniprotkb/E1B791-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARICPGLLLWMTVAALASRGVQAWDSKKVTREFQDIPASYVYVQQALWFAMKEYNKASKDTYVYKVMNVLRSQEQVTDSLDYLLEVEIERTQCKKISGKTENCSAQEDPQMQKAFYCTFIVASKPWKFELQMLKKECSPI", "length": 141, "header": "tr|E1B791-1|E1B791_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC531692 PE=3 SV=1 CANONICAL=E1B791-1" }, "isoforms": [ { "isoform_ac": "E1B791-1", "url": "https://www.uniprot.org/uniprotkb/E1B791/entry", "sequence": { "sequence": "MARICPGLLLWMTVAALASRGVQAWDSKKVTREFQDIPASYVYVQQALWFAMKEYNKASKDTYVYKVMNVLRSQEQVTDSLDYLLEVEIERTQCKKISGKTENCSAQEDPQMQKAFYCTFIVASKPWKFELQMLKKECSPI", "length": 141, "header": "tr|E1B791-1|E1B791_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC531692 PE=3 SV=1 CANONICAL=E1B791-1" }, "locus": { "chromosome": "13", "start_pos": 42152196, "end_pos": 42144612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021208.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021208.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021208.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021208.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531692", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531692", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N4Z6-1", "protein_name": "Cystatin-13", "gene_name": "LOC100766873", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARFFQALLFLVITVGLVSKRVQAWGSQKIVRPFEDIPKTYVYVQQAVWFAMKEYNKASKDRYNFKVIDILKSQEQVTDSLEYYIEVKIARTMCKKTVGENENCLFQHDPKMKKMVFCIFIVASKPWKFELKMLKKQCNDI", "length": 141 }, "evidence": [ { "id": "E1B791", "url": "https://omabrowser.org/oma/group/E1B791/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZNB1-1", "protein_name": "Cystatin 13", "gene_name": "Cst13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARFLQTLMFLVITVEFVSRRVEAWGSPTIVRPFEDIPKSYVYVQHALWYAMKEYNKASNDQYNFKVVDILKSQEQITDSLEYYLEVNIARTMCKKIAGDNENCLIQNDPKMKKMVFCIFIVSSKPWKFELKMLKKQCKDI", "length": 141 }, "evidence": [ { "id": "E1B791", "url": "https://omabrowser.org/oma/group/E1B791/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80ZN5-1", "protein_name": "Cystatin-13", "gene_name": "Cst13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARFLQTLLFLVIMVEFVSRRVEAWGSPQIVRPFEDIPKSYVYVQHALWYAMKEYNKASNDLYNFRVVDILKSQEQITDSLEYYLEVNIARTMCKKIAGDNENCLFQQDPKMKKMVFCIFIVSSKPWKFELKMLKKQCKDI", "length": 141 }, "evidence": [ { "id": "E1B791", "url": "https://omabrowser.org/oma/group/E1B791/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "E1B791", "url": "https://www.uniprot.org/uniprotkb/E1B791" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B791-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 141, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B791-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B791" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B791" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 139, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7B8-1", "uniprot_ac": "E1B7B8", "uniprot_id": "E1B7B8_BOVIN", "mass": { "chemical_mass": 34195.0, "monoisotopic_mass": 34195.0 }, "refseq": { "ac": "NP_001377388", "name": "olfactory receptor 13H1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377388" }, "gene_names": [ { "name": "OR13H1", "type": "recommended", "evidence": [ { "id": "E1B7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" } ] }, { "name": "OR13H1", "type": "synonym", "evidence": [ { "id": "NP_001377388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377388" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 13 subfamily H member 1", "type": "synonym", "evidence": [ { "id": "E1B7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 13H1", "type": "synonym", "evidence": [ { "id": "NP_001377388", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377388" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377388" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR13H1", "url": "https://www.uniprot.org/uniprotkb/E1B7B8", "locus": { "chromosome": "X", "start_pos": 15553899, "end_pos": 15552973, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007647", "url": "https://www.ensembl.org/id/ENSBTAG00000007647" } ] } } ], "crossref": [ { "id": "E1B7B8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7B8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15431", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15431", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786155", "url": "https://www.ncbi.nlm.nih.gov/gene/786155", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786155", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786155", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYGTVSM", "url": "https://omabrowser.org/oma/group/CYGTVSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7B8", "url": "https://www.orthodb.org/?gene=E1B7B8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377388", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7B8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7B8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMDNATAVFEFLLIGISNYPEWRVTFFTLVLITYLSTLLGNGLIIFLIYIDPHLHTPMYFFLSNLSFLDLCYGTVSMPQALVHCFSAHPYLSYPRCLTQISVSLALGTAECLLLAVMAHDRVVAIGNPLRYSVVMNSSVCVWLAATSWGASLVLTSMLILPLRLHFCEANVINHFVCEILSLLKLACSDTSLNELLILITSIFTLLLPFGFVLLSYVRIAAAVLRIRSAQGRLKAFSTCASHVTVVVIFYGAAISMYMKPQSKSSSDQDKFISVFYGALTPMLNPLIYSLRNKDVKGAMRKVMAKRT", "length": 308, "header": "tr|E1B7B8-1|E1B7B8_BOVIN Isoform 1 of Olfactory receptor family 13 subfamily H member 1 OS=Bos taurus OX=9913 GN=OR13H1 PE=3 SV=3 CANONICAL=E1B7B8-1" }, "isoforms": [ { "isoform_ac": "E1B7B8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7B8/entry", "sequence": { "sequence": "MAMDNATAVFEFLLIGISNYPEWRVTFFTLVLITYLSTLLGNGLIIFLIYIDPHLHTPMYFFLSNLSFLDLCYGTVSMPQALVHCFSAHPYLSYPRCLTQISVSLALGTAECLLLAVMAHDRVVAIGNPLRYSVVMNSSVCVWLAATSWGASLVLTSMLILPLRLHFCEANVINHFVCEILSLLKLACSDTSLNELLILITSIFTLLLPFGFVLLSYVRIAAAVLRIRSAQGRLKAFSTCASHVTVVVIFYGAAISMYMKPQSKSSSDQDKFISVFYGALTPMLNPLIYSLRNKDVKGAMRKVMAKRT", "length": 308, "header": "tr|E1B7B8-1|E1B7B8_BOVIN Isoform 1 of Olfactory receptor family 13 subfamily H member 1 OS=Bos taurus OX=9913 GN=OR13H1 PE=3 SV=3 CANONICAL=E1B7B8-1" }, "locus": { "chromosome": "X", "start_pos": 15553896, "end_pos": 15552973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010061.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010061.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010061.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010061.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786155", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786155", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RTF4-1", "protein_name": "Olfactory receptor family 13 subfamily H member 1", "gene_name": "OR13H1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKDNATAVLEFLLIGIANYPEWRVTFFTLVLITYLSTLLGNGLIIFLIYMDPHLHTPMYFFLSNLSFLDLCYGTVSLPQVLVHCFSTRPYLSYPRCLTQISVSLVLGTAECLLLAVMAYDRVVAISHPLRYAVVMSGPVCVWLAAASWGSSLVLSAMLLLSLQLHFCGANVINHFVCEILSLLKLACSDTSLHELMILIAGIFTLLLPFGFVLLSYVRIAVAVLRIRSVQGRLKAFSTCGSHLTVVTIFYGAAISTYMKPQSKLSPDRDKFISVFYGALTPMLNPLIYSLRNKDVKGAMRKVMAKKA", "length": 308 }, "evidence": [ { "id": "E1B7B8", "url": "https://omabrowser.org/oma/group/E1B7B8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NG92-1", "protein_name": "Olfactory receptor 13H1", "gene_name": "OR13H1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMDNVTAVFQFLLIGISNYPQWRDTFFTLVLIIYLSTLLGNGFMIFLIHFDPNLHTPIYFFLSNLSFLDLCYGTASMPQALVHCFSTHPYLSYPRCLAQTSVSLALATAECLLLAAMAYDRVVAISNPLRYSVVMNGPVCVCLVATSWGTSLVLTAMLILSLRLHFCGANVINHFACEILSLIKLTCSDTSLNEFMILITSIFTLLLPFGFVLLSYIRIAMAIIRIRSLQGRLKAFTTCGSHLTVVTIFYGSAISMYMKTQSKSYPDQDKFISVFYGALTPMLNPLIYSLRKKDVKRAIRKVMLKRT", "length": 308 }, "evidence": [ { "id": "E1B7B8", "url": "https://omabrowser.org/oma/group/E1B7B8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1B7B8", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7B8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7B8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7B8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7C1-1", "uniprot_ac": "E1B7C1", "uniprot_id": "E1B7C1_BOVIN", "mass": { "chemical_mass": 56627.0, "monoisotopic_mass": 56627.0 }, "refseq": {}, "gene_names": [ { "name": "LAG3", "type": "recommended", "evidence": [ { "id": "E1B7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ] } ], "protein_names": [ { "name": "Lymphocyte activation gene 3 protein", "type": "recommended", "evidence": [ { "id": "E1B7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1#function" }, { "database": "UniProtKB", "id": "ARBA00057112", "url": "https://www.uniprot.org/uniprotkb/ARBA00057112#function" }, { "database": "UniProtKB", "id": "A0A3Q1LYZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAG3", "url": "https://www.uniprot.org/uniprotkb/E1B7C1", "locus": { "chromosome": "5", "start_pos": 103666049, "end_pos": 103672501, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034295", "url": "https://www.ensembl.org/id/ENSBTAG00000034295" } ] } } ], "crossref": [ { "id": "ENSBTAG00000034295", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034295", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LWVAPVE", "url": "https://omabrowser.org/oma/group/LWVAPVE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LYZ8", "url": "https://www.orthodb.org/?gene=A0A3Q1LYZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7C1", "url": "https://www.orthodb.org/?gene=E1B7C1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7C1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLWEAWFQVWLFLQLLWAAAVEAPEPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLPRTRQVTWQHVPESGSAAPTPRGPGPRRYTVLRLAPGGLRIGKLPLQPRVQLEEMGLQRGDFSLWLRPARRADAGEYHAAVRFGNRALACRLRLRVGQAAVTASPPGPLWTSSWVVLNCSFSRPDLPASVHWFRGPGRVPVQESPHHHLVGNFLFLPQVSSLDSGTWGCSLTYRDGFNVSITYNLAVLGLEPRATLTVYAGAGSKVELPCRLPPGVGIQSSLTAMWTPPGEGPDLLVAGDRNNFTLRLEAVGQAQAGTYTCRVHLQGRQLSATVTLAVITVTPKPYGSSGSLRKPFCEVTPASGQERFVWSPLDKRSQRRSPGPWLLTPDARPLSQPWQCHLYQGERLLGTAVYLTELSHPGAQRSGRALGAGRTAHLPLLILGLLFLLLLVTGASSFHLWRRQWRPRRFSALEHGTHPSQASSKTGELEPELEPEPDPEVEPEPEPEPESQPQLQPEQP", "length": 516, "header": "tr|E1B7C1-1|E1B7C1_BOVIN Isoform 1 of Lymphocyte activation gene 3 protein OS=Bos taurus OX=9913 GN=LAG3 PE=3 SV=2 CANONICAL=E1B7C1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ8/entry", "sequence": { "sequence": "MLWEAWFQVWLFLQLLWAAAVEAPEPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLPRTRQVTWQHVPERHGCLSGSGWCWPNWNEGTGRLAVQKSSLGSAAPTPRGPGPRRYTVLRLAPGGLRIGKLPLQPRVQLEEMGLQRGDFSLWLRPARRADAGEYHAAVRFGNRALACRLRLRVGQAAVTASPPGPLWTSSWVVLNCSFSRPDLPASVHWFRGPGRVPVQESPHHHLVGNFLFLPQVSSLDSGTWGCSLTYRDGFNVSITYNLAVLGLEPRATLTVYAGAGSKVELPCRLPPGVGIQSSLTAMWTPPGEGPDLLVAGDRNNFTLRLEAVGQAQAGTYTCRVHLQGRQLSATVTLAVITVTPKPYGSSGSLRKPFCEVTPASGQERFVWSPLDKRSQRRSPGPWLLTPDARPLSQPWQCHLYQGERLLGTAVYLTELSHPGAQRSGRALGAGRTAHLPLLILGLLFLLLLVTGASSFHLWRRQWRPRRFSALEHGTHPSQASSKTGELEPELEPEPDPEVEPEPEPEPESQPQLQPEQP", "length": 544, "header": "tr|A0A3Q1LYZ8-1|A0A3Q1LYZ8_BOVIN Computationally mapped isoform of Lymphocyte activation gene 3 protein OS=Bos taurus OX=9913 GN=LAG3 PE=3 SV=1 CANONICAL=E1B7C1-1" }, "locus": { "chromosome": "5", "start_pos": 103672263, "end_pos": 103666114, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077596.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077596.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066027.1" } ] } }, { "isoform_ac": "E1B7C1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1/entry", "sequence": { "sequence": "MLWEAWFQVWLFLQLLWAAAVEAPEPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLPRTRQVTWQHVPESGSAAPTPRGPGPRRYTVLRLAPGGLRIGKLPLQPRVQLEEMGLQRGDFSLWLRPARRADAGEYHAAVRFGNRALACRLRLRVGQAAVTASPPGPLWTSSWVVLNCSFSRPDLPASVHWFRGPGRVPVQESPHHHLVGNFLFLPQVSSLDSGTWGCSLTYRDGFNVSITYNLAVLGLEPRATLTVYAGAGSKVELPCRLPPGVGIQSSLTAMWTPPGEGPDLLVAGDRNNFTLRLEAVGQAQAGTYTCRVHLQGRQLSATVTLAVITVTPKPYGSSGSLRKPFCEVTPASGQERFVWSPLDKRSQRRSPGPWLLTPDARPLSQPWQCHLYQGERLLGTAVYLTELSHPGAQRSGRALGAGRTAHLPLLILGLLFLLLLVTGASSFHLWRRQWRPRRFSALEHGTHPSQASSKTGELEPELEPEPDPEVEPEPEPEPESQPQLQPEQP", "length": 516, "header": "tr|E1B7C1-1|E1B7C1_BOVIN Isoform 1 of Lymphocyte activation gene 3 protein OS=Bos taurus OX=9913 GN=LAG3 PE=3 SV=2 CANONICAL=E1B7C1-1" }, "locus": { "chromosome": "5", "start_pos": 103672263, "end_pos": 103666114, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048582.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048582.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045595.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045595.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 76, "start_aa": "Thr", "end_pos": 76, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr76", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZMF0-1", "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "LAG3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPVSPVLFLTLLAVNAGNILPGAAEVENRGQKVWAREGSSALLPCYLSPRKHGKSRKHLSGRTSVLWKRHGASAPQELHVVLEVEYTGLRKTALPMRPRVSVLDSALRNGNFSLCINPVRSDDVGLYEAQVAYNTEILSCQVELGVVTVTLSPPLPVVENEPLLLSCNSSHQASLVETCWFHNGRPVLISGAFCSSHGALYILRPTVSDSGSWHCQLRYADNEIISATYNLQILGFDGPTNPVVYAAAGSAADLPCTLNYLPSASGIRVVKAHWSHFAGGHLQNWSILQNQSSRNFPLHLPVVGPGDAGRYCCAVTVGNKMLSRDMTLAVITVTPRIQGPVSEGSHLLLTCSLTNPQGHEYFQWKHLSSASAEKKLTVATSHNLKDSRVRTGPTLEIPQVSQKDVGIWECSVYGPEGRLGAVEYGLQITGAQVSGPPTIFSGQVTFGLMLTLFFLLMVCILALGLQKRARLPASFPALERIVAVTVPKEMEESQKETIQQTEC", "length": 504 }, "evidence": [ { "id": "E1B7C1", "url": "https://omabrowser.org/oma/group/E1B7C1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SLT3-1", "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "LAG3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEAHFLIWLLLQLLCAAAVEAPDPRAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRTGQVTWQHLPDRGPAAPSPQSPGPRRYTVLRVAPGGLRIGRPPLQPRVQLEERGLQRGDFSLWLRPARRDDAGEYRAAVSLRDRDRALVCLLRLRVGQAAVTASPPGSLWTSHWVILNCSFSRPDFPASVHWFRGPGRVPVQESPHQHLVGNFLFLSQISPLDSGTWGCIITYRDGFNVSITYNLTVLGLQPPVPLTVYAAAGATVDLPCHLPRGVGTQSSLTATWTPPGGGPDLLVAGDHGNFTLRLEAVSQAQAGTYTCRVHLQGQQLSATVTLAVITVTPKSSGLPGNPKKLLCEVTPASGQERFVWSSLDKRSWRSSPGPWLVLQEARLLSQPWQCQLYEGERLLGTAGYFTELSRPGAQRSGGALGAQKTGHLPFLILGTLLLLLLVSGAISFHVWRRRWRPRRFSALEHGTHPPQAQSKTGELEPEPELEPEPELEVEPQPEQP", "length": 507 }, "evidence": [ { "id": "E1B7C1", "url": "https://omabrowser.org/oma/group/E1B7C1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P18627-1", "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "LAG3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFTELSSPGAQRSGRAPGALPAGHLLLFLILGVLSLLLLVTGAFGFHLWRRQWRPRRFSALEQGIHPPQAQSKIEELEQEPEPEPEPEPEPEPEPEPEQL", "length": 525 }, "evidence": [ { "id": "E1B7C1", "url": "https://omabrowser.org/oma/group/E1B7C1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5BK54-1", "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "Lag3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRQDLFLDLLLLQLLWEAPVVSSGPGKELSVVWAQEGAPVHLPCSLEFPHLDPNFLRRGWVTWQHRPDSDQPASIPALDLLQGMPSTRRHPPHRYTVLSVAPGGLRSGRQPLLSHVQLEKRGPQRGDFSLWLRPATRKDAGEYHAFVRLPDRDFSCSLRLRVGQASMIASPPGTLKPSDWVILNCSFSRPDRPVSVHWFQGQSRVPVHNSPRHYLAESFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVQGLEPVAPLTVYAAEGSRVELPCHLPPVVGTPSLLIAKWTPPGGGPELPVTGKSGNFTLQLENVGRAQAGTYTCSIHLQGRQLSAAVTLAVITVTPKSFGLPGSPQKLLCEVVPASGEGRFVWRPLSDLSRSSLGPVLELQEAKLLAEQWQCQLYEGQKLLGATVYTAESSSGAWSAKRISGDLKGGHLFLSLILGALALFLLVTGAFGFHLWRRQLLRRRFSALEHGIRPPPVQSKIEELEREPETEMEPETEPDPEPQPEPELEPESRQL", "length": 525 }, "evidence": [ { "id": "E1B7C1", "url": "https://omabrowser.org/oma/group/E1B7C1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61790-1", "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "Lag3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MREDLLLGFLLLGLLWEAPVVSSGPGKELPVVWAQEGAPVHLPCSLKSPNLDPNFLRRGGVIWQHQPDSGQPTPIPALDLHQGMPSPRQPAPGRYTVLSVAPGGLRSGRQPLHPHVQLEERGLQRGDFSLWLRPALRTDAGEYHATVRLPNRALSCSLRLRVGQASMIASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVPVYNSPRHFLAETFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVLGLEPVAPLTVYAAEGSRVELPCHLPPGVGTPSLLIAKWTPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQLNATVTLAVITVTPKSFGLPGSRGKLLCEVTPASGKERFVWRPLNNLSRSCPGPVLEIQEARLLAERWQCQLYEGQRLLGATVYAAESSSGAHSARRISGDLKGGHLVLVLILGALSLFLLVAGAFGFHWWRKQLLLRRFSALEHGIQPFPAQRKIEELERELETEMGQEPEPEPEPQLEPEPRQL", "length": 521 }, "evidence": [ { "id": "E1B7C1", "url": "https://omabrowser.org/oma/group/E1B7C1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "plasmacytoid dendritic cell activation", "id": "GO:0002270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002270", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "negative regulation of regulatory T cell differentiation", "id": "GO:0045590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045590", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "negative regulation of T cell mediated immune response to tumor cell", "id": "GO:0002841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002841", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "MHC class II protein binding", "id": "GO:0042289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042289", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" }, { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "E1B7C1", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 236, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 76 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 174, "end_pos": 176 }, { "start_pos": 234, "end_pos": 236 }, { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7G6-1", "uniprot_ac": "E1B7G6", "uniprot_id": "E1B7G6_BOVIN", "mass": { "chemical_mass": 157294.0, "monoisotopic_mass": 157294.0 }, "refseq": { "ac": "XP_005217660", "name": "ankyrin repeat domain-containing protein 50 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217660" }, "gene_names": [ { "name": "ANKRD50", "type": "recommended", "evidence": [ { "id": "E1B7G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G6" } ] }, { "name": "ANKRD50", "type": "synonym", "evidence": [ { "id": "XP_005217660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217660" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain containing 50", "type": "synonym", "evidence": [ { "id": "E1B7G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G6/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 50 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217660" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7G6", "url": "https://www.uniprot.org/uniprotkb/E1B7G6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD50", "url": "https://www.uniprot.org/uniprotkb/E1B7G6", "locus": { "chromosome": "17", "start_pos": 33168247, "end_pos": 33131767, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001117", "url": "https://www.ensembl.org/id/ENSBTAG00000001117" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001117", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001117", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527956", "url": "https://www.ncbi.nlm.nih.gov/gene/527956", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CKIMVPS", "url": "https://omabrowser.org/oma/group/CKIMVPS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7G6", "url": "https://www.orthodb.org/?gene=E1B7G6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24883", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24883", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217660", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217660", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7G6", "url": "https://www.uniprot.org/uniprotkb/E1B7G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7G6-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLANVDGKKPIMTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKTNCCNSAVNTPPLVMNSGNNASVVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPTSLQRGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGMKPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAELLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTITELYHAVWTKNMSLTLEDFQRKLDVLSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGNLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNYKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHLEMVQVLITYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSVSSKMQSLTIKSNSSGSTGGGEAQPSLRSLPNGPAHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHSLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHHSPSSEFEWSQVKPSLKSTKTNKGGKSENSNKSGSAGKKAKQNNSSQPKVLEYEMTQFDKRGPTAKSGTSAPSKQMPADSQCKIMIPSAQPEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTIQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL", "length": 1440, "header": "tr|E1B7G6-1|E1B7G6_BOVIN Isoform 1 of Ankyrin repeat domain containing 50 OS=Bos taurus OX=9913 GN=ANKRD50 PE=4 SV=3 CANONICAL=E1B7G6-1" }, "isoforms": [ { "isoform_ac": "E1B7G6-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G6/entry", "sequence": { "sequence": "MLANVDGKKPIMTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKTNCCNSAVNTPPLVMNSGNNASVVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPTSLQRGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGMKPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAELLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTITELYHAVWTKNMSLTLEDFQRKLDVLSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGNLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNYKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHLEMVQVLITYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSVSSKMQSLTIKSNSSGSTGGGEAQPSLRSLPNGPAHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHSLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHHSPSSEFEWSQVKPSLKSTKTNKGGKSENSNKSGSAGKKAKQNNSSQPKVLEYEMTQFDKRGPTAKSGTSAPSKQMPADSQCKIMIPSAQPEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTIQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL", "length": 1440, "header": "tr|E1B7G6-1|E1B7G6_BOVIN Isoform 1 of Ankyrin repeat domain containing 50 OS=Bos taurus OX=9913 GN=ANKRD50 PE=4 SV=3 CANONICAL=E1B7G6-1" }, "locus": { "chromosome": "17", "start_pos": 33165943, "end_pos": 33131966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067076.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067076.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062734.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062734.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1LWB9-1", "protein_name": "Ankyrin repeat domain containing 50", "gene_name": "Ankrd50", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSSRCFSAANAQSLVGDAGNNASALSGKGASWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICQSGLLQGYEDKLRDPAVQSLLEPGECERNPAEAFKRCVLLPLLGMKPPPQSLYLLVDSVDEGCNVVEGEQTSPNLSGTVAELLAGHHEFFPPWLLLLCSARKQSRAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAETLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTMTELYHAVWTKNMSLTLEDFQRKLDVLSKLLVDGLGSTKILFHHSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQARNLTPLEAQEFALHLINSNLQLEPAELALWMIWNGTPVKDSLSTLIPKEQEVLQLLIRAGAHVNSEDDRTSCIVRQALEREDSIRTLLDSGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDTHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDESHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNYKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHVEMVRVLIACHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHVDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPPQSTPSKMQSLTIRSNSSGGTGGGDLQPSLRGLPNGPAHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHSLSFTEQIQQHSLPRSRSRQSVVSPSSTTQSLGHSHNSPSSEFEWSQVKPSLKSTKSNKGGKSENSSKSGSAGKKAKQNNSSQPKVLEYEMTQFDKRGPVAKSGSSPPKQMPAESQCKIMVPSSQDSNRAQPQFLIHQQGGEQKRRNGIMTNPNYHLQSNQVFLGRVSVPRTLQERGHQEVLEGFPPSETELNLKQALKLQIEGSDPSFNYKKETPL", "length": 1427 }, "evidence": [ { "id": "E1B7G6", "url": "https://omabrowser.org/oma/group/E1B7G6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NLN5-1", "protein_name": "Ankyrin repeat domain containing 50", "gene_name": "ANKRD50", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQTSLLQGKQFYCREWVFHKLQHCLQEKANCSGSAANKPSLVASSGNNTGVVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPANLQRGLHRQALAFHFCRAQDSDTLCVGGFIRGLVAQICRSGLIQGYEDKLRDPAIQSLLQPGECERNPAEAFKRCILLPLLGMKPPQQSLFLLVDSVDEGCNVSEGEQTSTSLSGTIAELLAGHFEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTTTELYHAVWTKNMTLTMEDFQRKLDVLSKVLIDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCRAKDLTPLEAQEFALHLINSNLKLETSELALWMIWNGTPVKDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGNLDVVNLLVSRGADLEVEDTHGQTALTLAARQGHTKVVNCLIGCGANVNHTDHDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHKEIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILAAQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHREIVELLLSHGADVNYKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHLEMVQVLITYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGALVDHTCNQGATGLCIAAQEGHIDVVQILLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASTLNGCTPSPVHTMEQKPLQSVSSKMQSLTMKSNSSGSTGGDMQPSMRGLSNGPAHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHSLSFTEQIQQHSLPRSRSRQSIVSPSSTTHSLSQNHNSPSSEFEWSQVKPSLKSTKANKGGKTDNSSKSGSAGKKIKQNSSTQPKVLEYEMTQFDKRVPIAKSGTSVPLKSMPPEPQCKILVPPAQQEVGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTVQDRGHQEVLEGYPSAETELSLKQALKLQIEGGDPSFNYKKETPL", "length": 1417 }, "evidence": [ { "id": "E1B7G6", "url": "https://omabrowser.org/oma/group/E1B7G6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9ULJ7-1", "protein_name": "Ankyrin repeat domain-containing protein 50", "gene_name": "ANKRD50", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGMKPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL", "length": 1429 }, "evidence": [ { "id": "E1B7G6", "url": "https://omabrowser.org/oma/group/E1B7G6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "E1B7G6", "url": "https://www.uniprot.org/uniprotkb/E1B7G6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1147, "end_pos": 1149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1192, "end_pos": 1194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1200, "end_pos": 1202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1288, "end_pos": 1290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1300, "end_pos": 1302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1301, "end_pos": 1303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 616, "end_pos": 618, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" }, { "start_pos": 913, "end_pos": 915, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G6" }, { "id": "PF24883", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24883" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nephrocystin 3-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 85, "end_pos": 210, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G6" }, { "id": "PF25520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TANC1/2-like AAA+ ATPase lid", "eco_id": "ECO_0000259", "start_pos": 266, "end_pos": 350, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G6" }, { "id": "PF25521", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25521" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TANC1/2-like winged helix", "eco_id": "ECO_0000259", "start_pos": 351, "end_pos": 475, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1147, "end_pos": 1149 }, { "start_pos": 1192, "end_pos": 1194 }, { "start_pos": 1200, "end_pos": 1202 }, { "start_pos": 1288, "end_pos": 1290 }, { "start_pos": 1300, "end_pos": 1302 }, { "start_pos": 1301, "end_pos": 1303 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 457, "end_pos": 459 }, { "start_pos": 489, "end_pos": 491 }, { "start_pos": 616, "end_pos": 618 }, { "start_pos": 71, "end_pos": 73 }, { "start_pos": 913, "end_pos": 915 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7G7-1", "uniprot_ac": "E1B7G7", "uniprot_id": "E1B7G7_BOVIN", "mass": { "chemical_mass": 85296.0, "monoisotopic_mass": 85296.0 }, "refseq": { "ac": "NP_001179755", "name": "pleckstrin homology domain-containing family H member 3 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179755" }, "gene_names": [ { "name": "PLEKHH3", "type": "recommended", "evidence": [ { "id": "E1B7G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G7" } ] }, { "name": "PLEKHH3", "type": "synonym", "evidence": [ { "id": "NP_001179755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179755" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain-containing family H member 3", "type": "recommended", "evidence": [ { "id": "E1B7G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G7/entry#names_and_taxonomy" } ] }, { "name": "pleckstrin homology domain containing, family H (with MyTH4 domain) member 3", "type": "synonym", "evidence": [ { "id": "NP_001179755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179755" } ] }, { "name": "pleckstrin homology domain-containing family H member 3 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179755" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7G7", "url": "https://www.uniprot.org/uniprotkb/E1B7G7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHH3", "url": "https://www.uniprot.org/uniprotkb/E1B7G7", "locus": { "chromosome": "19", "start_pos": 42725940, "end_pos": 42734368, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019090", "url": "https://www.ensembl.org/id/ENSBTAG00000019090" } ] } } ], "crossref": [ { "id": "E1B7G7", "url": "https://alphafold.ebi.ac.uk/entry/E1B7G7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019090", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019090", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541100", "url": "https://www.ncbi.nlm.nih.gov/gene/541100", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541100", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541100", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QCLMGDF", "url": "https://omabrowser.org/oma/group/QCLMGDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7G7", "url": "https://www.orthodb.org/?gene=E1B7G7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46049:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46049:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00784", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00784", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179755", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7G7", "url": "https://www.uniprot.org/uniprotkb/E1B7G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7G7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLDVTLTQPMRSGPVSDRLQSWEETRSLIPEKGPSEDDPDVVVKGWLYREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVSGPERRPKETGLWSVTVSGRKHSVRLCSPRQSEAECWGVALREVIASKAPLETPTQLLLRDIQESRGDPEAVALIYRRNPILRHTSGALYAPLLPLPYGVTAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGPPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRRALGRTRGRELVPSLAEISALSRRQELLCTVHCPGAGACPVAIDSHTTAGEVARELVGRLGLTRSRNTFALYEQRGAQERALAGGTLVADVLTRFENLAAEEAGLEDPPDTGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFPPRAPLPRLDRLLPTPARPREDPPRPVPRPPPSAALLAGAIWSPSLAKRRAERARHGGAGRTAGSVAREGGGGAGRAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLELSTEPGGGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGRVAACQLMGPHTLALRVGESQLLLQSPQVEEIVQLVNAYLANPSPERPSSSPPPCQDLPDTSPPSQHPGLDEPQGQSGCLGQLQD", "length": 792, "header": "tr|E1B7G7-1|E1B7G7_BOVIN Isoform 1 of Pleckstrin homology domain-containing family H member 3 OS=Bos taurus OX=9913 GN=PLEKHH3 PE=4 SV=2 CANONICAL=E1B7G7-1" }, "isoforms": [ { "isoform_ac": "E1B7G7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G7/entry", "sequence": { "sequence": "MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLDVTLTQPMRSGPVSDRLQSWEETRSLIPEKGPSEDDPDVVVKGWLYREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVSGPERRPKETGLWSVTVSGRKHSVRLCSPRQSEAECWGVALREVIASKAPLETPTQLLLRDIQESRGDPEAVALIYRRNPILRHTSGALYAPLLPLPYGVTAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGPPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRRALGRTRGRELVPSLAEISALSRRQELLCTVHCPGAGACPVAIDSHTTAGEVARELVGRLGLTRSRNTFALYEQRGAQERALAGGTLVADVLTRFENLAAEEAGLEDPPDTGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFPPRAPLPRLDRLLPTPARPREDPPRPVPRPPPSAALLAGAIWSPSLAKRRAERARHGGAGRTAGSVAREGGGGAGRAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLELSTEPGGGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGRVAACQLMGPHTLALRVGESQLLLQSPQVEEIVQLVNAYLANPSPERPSSSPPPCQDLPDTSPPSQHPGLDEPQGQSGCLGQLQD", "length": 792, "header": "tr|E1B7G7-1|E1B7G7_BOVIN Isoform 1 of Pleckstrin homology domain-containing family H member 3 OS=Bos taurus OX=9913 GN=PLEKHH3 PE=4 SV=2 CANONICAL=E1B7G7-1" }, "locus": { "chromosome": "19", "start_pos": 42734334, "end_pos": 42726152, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025419.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025419.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025419.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025419.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541100", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541100", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GF27-1", "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "Plekhh3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MCLWASRRTQGAVHLLGALRQRRRHAWPDLALPLPSLPGPRPIPSPSASARAKECGEAGWAARTPGFALLTVHEHWGQMRELSPREPGQGKKDSLELGSASGTLQRKSWGRWPFEDLSLSCHLGQKSLPSLGSLDVALTQPTRSGLVSDRLQSWEETWSLIPDKGLPEDDPDVVVKGWLYREPRGGGARPWLLPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRPKETGLWSVTVSGRKHSIRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYRRNPILRHSSSALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALQDELFLQLAKQTSGPAGPPGFPATQDPATLRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSRRQELLCTVHCPGAGACPVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLTSEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHQDFSPRGPLPRLDRLLPPPTPPREQSLRPTPRPQPSAALLAGALWSPGLAKRRAERARGGCTGCSTGSTAQVGGGGASRTTAVLGSWKRLRGMGQAEAMAAYLALAAQCPGFGAARYDVLELSTEPGGGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLIGPHTLALRVGDSQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSAPPCQDLPDSTPPSQHQGLEEPQGQSGCLGQLQD", "length": 870 }, "evidence": [ { "id": "E1B7G7", "url": "https://omabrowser.org/oma/group/E1B7G7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3ITQ9-1", "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "plekhh3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPLPGLCWLVCCRQGFSLLARDHGEKEEEESFELRNQDEHTHTGRGQLEVTLSQPTRSANGTPCLSGVPEEKRSLITQKTKMTMDEDPEVVVKGWLLREVQGGWLRQRRFWFVLTSDSLDYYSGPDRDARRLGTLVLTSLCSVLWPDKHTYKQTGYWSLTVYGRKHCYRLFTKHYNEAVHWACAVQKVIDSKAPVETPTQLLIRDIEENKFNPEVVEHIYQHNPILRYTQSPLYAPLLPFPYGSLHHTHMASKGYTSIREEAVRLFNCLQQLESAREPIPLIQGILQTCLDLRPLRDELYCQLIKQTSTTSSRVQTQTNPNPQLRYWQLLTCMSCTFLPSCGILRYLRFHLKRVQSLSVDPEVESYASFIGQALEKTRGRECVPSWEEIQGLMGRQEILCTVHYPGPGCCQIPITSHTTANEVVRKMAERLGLQDSRNTFGLFEQNACWEKAIGGSTIIADVITRFENLSAKDPDSDCQCRLCFKLYCLLDTENISTDSIEYLFLYEQCHEMVVRGQLPACEEDLLSLAALRLQYLLGDFSALSPYPALEQLFPAEVVEARALLAPVDPPGCPSFPGGLLAGTLWGHKRRQEQDQRLRARLREEGAVVMSTILERWKALVGYSGRDSMAAYLTIARQWSGFGCTLYEVDFYISSTGSFSQKLWLGVAASCVTLYRQGEAEALESLPITQICSYGVSDSNTFRITAGDRDLLFETTKLTEIMQLMNAYFSATRRQLGKDDCISLETNPKLHPSLFELPSHPV", "length": 761 }, "evidence": [ { "id": "E1B7G7", "url": "https://omabrowser.org/oma/group/E1B7G7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3B7L1-1", "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "Plekhh3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDDETFELRSPSPAGGGRGSLDVTLTQPTRNGPITDRLQSWEETWSLIPDKGLPEDDPDVIVKGWLYREPRGGGARPWLLPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRPKETGLWSVTVSGRKHSIRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESGGDPEAVALIYRRNPILRHTSSALYAPLLPLPYEVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALQDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSRRQELLCTVHCPGAGACPVSIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTSLTSEEVGLEDSPDSGWRLCLRLHGPLHPEGLSPEGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRGPLPLLDRLMPPPAPPREQPSRPARRPPPSAALLAGALWSPGLAKRRAERARRIGTGRSTESTAQVGGGGGGSTTAAVLGGWKRLRGMGQAEAMAAYLALAAQCPGFGAARYDVLELSTEPGGGAPQKLCLGLGAKAMSLSRPGESEPIHSVSYGHVAACQLIGPHTLALRVGDSQLLLQSPQVEEIMELVNAYLANPSPERPCSSSGPPSQDLSDTSPPSQHQVLEKPQGQSGCLRQLQD", "length": 791 }, "evidence": [ { "id": "E1B7G7", "url": "https://omabrowser.org/oma/group/E1B7G7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z736-1", "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "PLEKHH3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVTLTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLQRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTLALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDEPQGQSGCLGQLQD", "length": 793 }, "evidence": [ { "id": "E1B7G7", "url": "https://omabrowser.org/oma/group/E1B7G7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCE9-1", "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "Plekhh3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDDETFELRTPSPAGGGRGSLDVTLTQPTRNGPISDRLQGWEETWSLIPDKGLPEEDPDIIVKGWLYREPRGGGARPWLLPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRPKETGLWSVTVSGRKHSIRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYRRNPILRHTSSALYAPLLPLPYEVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALQDELFLQLAKQTSGPAGPPGLPATQDPATLRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSRRQELLCTVHCPGAGACPVSIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLTSEEAGLEDSPDCGWRLCLRLHGPLHPEGLSPEGHELPFLFEQAHALLLRGRPPPPEDTLRALAALRLQSLHRDFSPRGPLPLLDRLLPPPIPPREQPPCPTRRPPPSAALLAGALWSPGLAKRRAERARRGGTGRSTGSTAQVGGGGASTTAAVLGGWKRLRGMGQAEAMAAYLALAAQCPGFGAARYDVLELSTEPGGGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLIGPHTLALRVGDSQLLLQSPQVEEIMELVNAYLANPSPERPCRSGSSSGPPSQDLPDTSPPSQHQVLEEPQGQSGCLKQLQD", "length": 796 }, "evidence": [ { "id": "E1B7G7", "url": "https://omabrowser.org/oma/group/E1B7G7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1B7G7", "url": "https://www.uniprot.org/uniprotkb/E1B7G7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7G7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 792, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7G7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7G7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G7" }, { "id": "PS50057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FERM", "eco_id": "ECO_0000259", "start_pos": 404, "end_pos": 754, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G7" }, { "id": "PS51016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MyTH4", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 399, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G7" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 199, "start_aa": "Asp", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7I1-1", "uniprot_ac": "E1B7I1", "uniprot_id": "E1B7I1_BOVIN", "mass": { "chemical_mass": 54116.0, "monoisotopic_mass": 54116.0 }, "refseq": { "ac": "NP_001193219", "name": "RNA-binding protein MEX3A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193219" }, "gene_names": [ { "name": "MEX3A", "type": "recommended", "evidence": [ { "id": "E1B7I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ] }, { "name": "MEX3A", "type": "synonym", "evidence": [ { "id": "NP_001193219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193219" } ] } ], "protein_names": [ { "name": "Mex-3 RNA binding family member A", "type": "synonym", "evidence": [ { "id": "E1B7I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I1/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein MEX3A", "type": "synonym", "evidence": [ { "id": "NP_001193219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193219" } ] }, { "name": "mex-3 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001193219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193219" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEX3A", "url": "https://www.uniprot.org/uniprotkb/E1B7I1", "locus": { "chromosome": "3", "start_pos": 14695864, "end_pos": 14690354, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019158", "url": "https://www.ensembl.org/id/ENSBTAG00000019158" } ] } } ], "crossref": [ { "id": "E1B7I1", "url": "https://alphafold.ebi.ac.uk/entry/E1B7I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019158", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019158", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16518", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16518", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22423", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22423", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22424", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22424", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618154", "url": "https://www.ncbi.nlm.nih.gov/gene/618154", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618154", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618154", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SMENRYS", "url": "https://omabrowser.org/oma/group/SMENRYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7I1", "url": "https://www.orthodb.org/?gene=E1B7I1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23285", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23285", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23285:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23285:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00013", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00013", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7I1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAALDSRYSEAWRVHPSGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPAASAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS", "length": 520, "header": "tr|E1B7I1-1|E1B7I1_BOVIN Isoform 1 of Mex-3 RNA binding family member A OS=Bos taurus OX=9913 GN=MEX3A PE=4 SV=3 CANONICAL=E1B7I1-1" }, "isoforms": [ { "isoform_ac": "E1B7I1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1/entry", "sequence": { "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAALDSRYSEAWRVHPSGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPAASAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS", "length": 520, "header": "tr|E1B7I1-1|E1B7I1_BOVIN Isoform 1 of Mex-3 RNA binding family member A OS=Bos taurus OX=9913 GN=MEX3A PE=4 SV=3 CANONICAL=E1B7I1-1" }, "locus": { "chromosome": "3", "start_pos": 14695699, "end_pos": 14690553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025498.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025498.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025498.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025498.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 57, "start_aa": "Thr", "end_pos": 57, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr57", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 93, "start_aa": "Thr", "end_pos": 93, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr93", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:618154", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618154", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1B0GWR7-1", "protein_name": "Mex-3 RNA binding family member A", "gene_name": "Mex3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAAPAAPSAAPAAQTPQPPTAPKGANDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNSDGDFLAGSPDAALDSRYSDAWRVHAPGCKPLSTFRQNSLGCIGECGVDSAFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSAKARAGPPGAHRSPATSAGPEQLTGLPRRPPGEPLQGFSKLGAGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS", "length": 520 }, "evidence": [ { "id": "E1B7I1", "url": "https://omabrowser.org/oma/group/E1B7I1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1A753-1", "protein_name": "Mex-3 RNA binding family member A", "gene_name": "MEX3A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSLLVPGIMERNGGFGDLGCFGGSGKDRALLEDDRALQLALDQLCLLGLGEPSSSSSSSAAVLVEDSNNNNNNPPPPPPPQQPPPPNPPPPPQPQPPPPPPPPPPAPKGPSAAGGGAAEPKLCALYKEAELRLKSSSNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVAMARREIISAAEHFSMIRASRNKAGTTFGSAPTLPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLSSSPDSSMENRYSEAWRVHTPAPGCKPLSTFRQNSLGCIGDCSVDPVYETPRLNDQNDFNYGYLFPNYGVNKQDLYYGVPESGAPMWAGQENTNPVSVLFSKQQRSSSTGAIHPNSHRSPSSSIQEPNLSALPRRSQGEPLQGFSKLGSTAAARTSVSSSRECMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHAAATQAIRIFS", "length": 527 }, "evidence": [ { "id": "E1B7I1", "url": "https://omabrowser.org/oma/group/E1B7I1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1L020-1", "protein_name": "RNA-binding protein MEX3A", "gene_name": "MEX3A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS", "length": 520 }, "evidence": [ { "id": "E1B7I1", "url": "https://omabrowser.org/oma/group/E1B7I1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "E7EXM9-1", "protein_name": "RNA-binding protein MEX3A", "gene_name": "mex3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPSLLVLAGIMEKNGGYGGDLAGSGFGSEGLLVPPEEEEDDSRALRVALGQLSLLGLGEGEDGAPAGGGGGGGGVQDRSNNNHHNHIQAEPGMLQGKNKLCALYESSPTETKGRGCNITECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFLITGRKEDVALARREIISAAEHFSMLRASRNKFSGSPPAPLPGQTTIQVRVPYRVVGLVVGPKGSTIKRIQQQTCTYIVTPSRDRDPVFEITGSPGNAERAREEIEAHIAFRTGGLHDHNNENDCLGPESGNGGLESRLQQVWGLQGAPRKPLASSYRQNFSDTVVGSSSGGGGGIYSKGDFNNHGSSGDKPSSYFGSEGTQSWGDPDYPKQVAYYAQQRSKSFGGLPLPLTRLSPGLPEPCGTGNSNAVGSPHAQARRAHSEPTAATGAFTGRLPVPDSPPAMSRDCMTCFESKVTAALVPCGHNLFCMECAIRICELNHPECPVCHTLVTQAIRIFS", "length": 502 }, "evidence": [ { "id": "E1B7I1", "url": "https://omabrowser.org/oma/group/E1B7I1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RLQ1-1", "protein_name": "Mex-3 RNA binding family member A", "gene_name": "MEX3A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAQPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAGLDSRYSEAWRVHPPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS", "length": 519 }, "evidence": [ { "id": "E1B7I1", "url": "https://omabrowser.org/oma/group/E1B7I1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3UYU0-1", "protein_name": "Mex3 RNA binding family member A", "gene_name": "Mex3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAAPAAPSAAPAAQTPQPPTAPKGANDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNSDGDFLAGSPDAALDSRYSDAWRVHAPGCKPLSTFRQNSLGCIGECGVDSAFEAPRLSEQGGDFGYSGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSAKARAGPPGAHRSPATSAGPEQLTGLPRRPPGEPLQGFSKLGTGGLRSPGSGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS", "length": 520 }, "evidence": [ { "id": "E1B7I1", "url": "https://omabrowser.org/oma/group/E1B7I1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "E1B7I1", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7I1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 520, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7I1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7I1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I1" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 469, "end_pos": 509, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 57, 93 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 208, "end_pos": 210 }, { "start_pos": 397, "end_pos": 399 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7L0-1", "uniprot_ac": "E1B7L0", "uniprot_id": "E1B7L0_BOVIN", "mass": { "chemical_mass": 40068.0, "monoisotopic_mass": 40068.0 }, "refseq": { "ac": "XP_002697643", "name": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697643" }, "gene_names": [ { "name": "SNRNP48", "type": "recommended", "evidence": [ { "id": "E1B7L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" } ] }, { "name": "SNRNP48", "type": "synonym", "evidence": [ { "id": "XP_002697643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697643" } ] } ], "protein_names": [ { "name": "Small nuclear ribonucleoprotein U11/U12 subunit 48", "type": "synonym", "evidence": [ { "id": "E1B7L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L0/entry#names_and_taxonomy" } ] }, { "name": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein", "type": "synonym", "evidence": [ { "id": "XP_002697643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697643" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7L0", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNRNP48", "url": "https://www.uniprot.org/uniprotkb/E1B7L0", "locus": { "chromosome": "23", "start_pos": 47800471, "end_pos": 47816696, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001123", "url": "https://www.ensembl.org/id/ENSBTAG00000001123" } ] } } ], "crossref": [ { "id": "E1B7L0", "url": "https://alphafold.ebi.ac.uk/entry/E1B7L0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001123", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001123", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513601", "url": "https://www.ncbi.nlm.nih.gov/gene/513601", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513601", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513601", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QEPMEQC", "url": "https://omabrowser.org/oma/group/QEPMEQC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7L0", "url": "https://www.orthodb.org/?gene=E1B7L0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21402", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21402", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21402:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21402:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697643", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697643", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7L0", "url": "https://www.uniprot.org/uniprotkb/E1B7L0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7L0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAELPPVEERRRLREELSEFVESCRRTLEEVTASLGWSLDRLEPGEEAAAAEDEVAICPYDSNHHMPRSSLAKHMMSCRLRRLGYTKEEEDKMYNSDFFYENANVPSITLNKDSQFQIIKQARAAVGNDGDYYNQRLYSSLPIEVPLNHKRFVCDLTQADRLALYDFVVEETKKKRSDSQIIENDSDLFVDLAAKVNQDNSRKSPKSYLEILAEVRDYKRRRQSYRAKNVHITKKSYTEVIRDVINVHMEELSSHWQEEQEKEADGADKSEERRSASVDSRHSGGSHLDGECSRHRRDRSRSPHRRKRNKDKDRGWDSRRRKERDGERHHSHKRRKQKM", "length": 340, "header": "tr|E1B7L0-1|E1B7L0_BOVIN Isoform 1 of Small nuclear ribonucleoprotein U11/U12 subunit 48 OS=Bos taurus OX=9913 GN=SNRNP48 PE=4 SV=1 CANONICAL=E1B7L0-1" }, "isoforms": [ { "isoform_ac": "E1B7L0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L0/entry", "sequence": { "sequence": "MEAELPPVEERRRLREELSEFVESCRRTLEEVTASLGWSLDRLEPGEEAAAAEDEVAICPYDSNHHMPRSSLAKHMMSCRLRRLGYTKEEEDKMYNSDFFYENANVPSITLNKDSQFQIIKQARAAVGNDGDYYNQRLYSSLPIEVPLNHKRFVCDLTQADRLALYDFVVEETKKKRSDSQIIENDSDLFVDLAAKVNQDNSRKSPKSYLEILAEVRDYKRRRQSYRAKNVHITKKSYTEVIRDVINVHMEELSSHWQEEQEKEADGADKSEERRSASVDSRHSGGSHLDGECSRHRRDRSRSPHRRKRNKDKDRGWDSRRRKERDGERHHSHKRRKQKM", "length": 340, "header": "tr|E1B7L0-1|E1B7L0_BOVIN Isoform 1 of Small nuclear ribonucleoprotein U11/U12 subunit 48 OS=Bos taurus OX=9913 GN=SNRNP48 PE=4 SV=1 CANONICAL=E1B7L0-1" }, "locus": { "chromosome": "23", "start_pos": 47816479, "end_pos": 47800495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001494.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001494.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001494.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001494.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513601", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513601", "resource": "KEGG Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7GQX1-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein", "gene_name": "Snrnp48", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEAEPPPLEERRRLQEELSEFVESCCRTLEEVTASLGWSLDQLDPGDQAEAEDEVTICPYDSNHHMPKSSLAKHMESCRLRKLGYAKEEEDEMHNPAFFYENLKIPSVTLNKDSQFQIIKQARTAAGKDGDCYSPRMYSSVPVEVPLNHKRSVCDLTQADRLALYDFVIEETKKNRSGSQVIENDSDLFVDLAAKVNQDNSRKSPKSYLEILAEVRDYKRRRQSYRAKNVHITKKSYTEVIRDVIKVHMEELSNHWQEEQERAEDGAEKNEERRSASVDSRQSGGSYLDVENSRHRRARSRSPHKRKRNKDKNSESRRRKERDGERHHSHKRRKQKI", "length": 337 }, "evidence": [ { "id": "E1B7L0", "url": "https://omabrowser.org/oma/group/E1B7L0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9D361-1", "protein_name": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein", "gene_name": "Snrnp48", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METEPPPLEERRRLQEELSEFVESCCRTLEEVTASLGWSLDQLDPGDEAEAEDEIAICPYDSNHRMPKSSLTKHMESCRLRKLGYTKEEENEMYNPTFFYENLKIPSVTLNKDSQFQIIKQARTTAGKDGDCYSQRMYSSVPVEVPLNHKRSVCDLTQTDRLALYDFVIEETKKKRSGPQVIENDSDLFVDLAAKVNQDNSRKSPKSYLEILAEVRDYKRRRQSYRAKNVHITKKSYTEVIRDVIKVHMEELSSHWQEEQGRAGDAAEKNEERRSASVDSRQSGGSYLDVESSRHRRARSRSPHKRKRNKDKSSESRRRKERDGERHHSHKRRKQKI", "length": 337 }, "evidence": [ { "id": "E1B7L0", "url": "https://omabrowser.org/oma/group/E1B7L0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7L0", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7L0", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" } ], "pmid": "" }, { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "E1B7L0", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7L0", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7L0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 340, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7L0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7L0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L0" }, { "id": "PS51800", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51800" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHHC U11-48K-type", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 83, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7N1-1", "uniprot_ac": "E1B7N1", "uniprot_id": "E1B7N1_BOVIN", "mass": { "chemical_mass": 66882.0, "monoisotopic_mass": 66882.0 }, "refseq": { "ac": "XP_002695688", "name": "amyloid protein-binding protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695688" }, "gene_names": [ { "name": "APPBP2", "type": "recommended", "evidence": [ { "id": "E1B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ] }, { "name": "APPBP2", "type": "synonym", "evidence": [ { "id": "XP_002695688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695688" } ] } ], "protein_names": [ { "name": "Amyloid protein-binding protein 2", "type": "recommended", "evidence": [ { "id": "E1B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7N1/entry#names_and_taxonomy" } ] }, { "name": "Amyloid beta precursor protein-binding protein 2", "type": "synonym", "evidence": [ { "id": "E1B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7N1/entry#names_and_taxonomy" } ] }, { "name": "amyloid protein-binding protein 2", "type": "synonym", "evidence": [ { "id": "XP_002695688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695688" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "APPBP2", "url": "https://www.uniprot.org/uniprotkb/E1B7N1", "locus": { "chromosome": "19", "start_pos": 12505251, "end_pos": 12448565, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004489", "url": "https://www.ensembl.org/id/ENSBTAG00000004489" } ] } } ], "crossref": [ { "id": "E1B7N1", "url": "https://alphafold.ebi.ac.uk/entry/E1B7N1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004489", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004489", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505734", "url": "https://www.ncbi.nlm.nih.gov/gene/505734", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505734", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505734", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YAESSHC", "url": "https://omabrowser.org/oma/group/YAESSHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7N1", "url": "https://www.orthodb.org/?gene=E1B7N1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46575", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46575", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46575:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46575:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13374", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13374", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695688", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695688", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7N1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFGKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMPHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITTSLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVNTSPQSTEEVVQSFLTAQNVEGPSC", "length": 585, "header": "tr|E1B7N1-1|E1B7N1_BOVIN Isoform 1 of Amyloid protein-binding protein 2 OS=Bos taurus OX=9913 GN=APPBP2 PE=4 SV=2 CANONICAL=E1B7N1-1" }, "isoforms": [ { "isoform_ac": "E1B7N1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1/entry", "sequence": { "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFGKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMPHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITTSLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVNTSPQSTEEVVQSFLTAQNVEGPSC", "length": 585, "header": "tr|E1B7N1-1|E1B7N1_BOVIN Isoform 1 of Amyloid protein-binding protein 2 OS=Bos taurus OX=9913 GN=APPBP2 PE=4 SV=2 CANONICAL=E1B7N1-1" }, "locus": { "chromosome": "19", "start_pos": 12504247, "end_pos": 12448764, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005887.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005887.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005887.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005887.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505734", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505734", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A5HK05-1", "protein_name": "Amyloid protein-binding protein 2", "gene_name": "Appbp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITSGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSTGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVNSSPQSTEEVVQSFLMSQNVEGPSC", "length": 585 }, "evidence": [ { "id": "E1B7N1", "url": "https://omabrowser.org/oma/group/E1B7N1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q92624-1", "protein_name": "Amyloid protein-binding protein 2", "gene_name": "APPBP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC", "length": 585 }, "evidence": [ { "id": "E1B7N1", "url": "https://omabrowser.org/oma/group/E1B7N1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAX9-1", "protein_name": "Amyloid protein-binding protein 2", "gene_name": "Appbp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSSSPQSTEEVVQSFLMAQNVEGPSC", "length": 585 }, "evidence": [ { "id": "E1B7N1", "url": "https://omabrowser.org/oma/group/E1B7N1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W3Y7-1", "protein_name": "Protein interacting with APP tail-1, isoform A", "gene_name": "Pat1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAGQQLVVLIPKINPNSPKTLYDLSLQALIGSMNTKIPALDRISRLAELPRNLLIDVYEMMSQQESLKDTLLEELAQLEVFARLVRYPFARSQLLRIMASLMASQKMLAKRLSENYVSRYEVVAGHEEEELESSMDTVEDRSTEFSSLYTYDSESTNADSISDFNDEFSADIGSIVGLPHRRATQEELDAINDSGLEELSAVELQVIDLGLRLGSFLSEAGWMQESITVLACLNVRLKDLPTHKHWLQFRLDCLQRLLYAESAHCNFKEAEKTYAELMGLNKWLNKSVPNQLVAITYSQISAMYFARNEYKNSHLWSGLAMRFLKGYANPRTIIDVLRQAAKACVVKRDFARANLLICQAVRRAREYFGPTHQKYGDALLDYGFFLLNVDSVFQSVNIYKEALAVRRGIFGNMNFHVAIAHEDLSYAYYVHEYSTGDFSCAQDHVDKAVNIMQHLVPSNHLMLASAKRVKALLLEEIALDKMADGIDEEDLLLQSEELHNFALLLSLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKKAIKIKSELLGHFDYEVGLSIGHLASLYNYQMKKYRDAEQLYMRSIDISLRLFGNSYSGLEYDYLGLCHVYETLHNFEKYLKYAHKLENWQMLRGQNLTQNKSSYPAIEVDYSIEEVKAKYFSMCASKKSAHPSVHEEDTVNEN", "length": 686 }, "evidence": [ { "id": "E1B7N1", "url": "https://omabrowser.org/oma/group/E1B7N1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" }, { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "id": "GO:0140627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140627", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" }, { "name": "negative regulation of beige fat cell differentiation", "id": "GO:0160276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160276", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1B7N1", "url": "https://www.uniprot.org/uniprotkb/E1B7N1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 561, "end_pos": 563, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7N1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 585, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7N1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7N1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 561, "end_pos": 563 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7P5-1", "uniprot_ac": "E1B7P5", "uniprot_id": "E1B7P5_BOVIN", "mass": { "chemical_mass": 83869.0, "monoisotopic_mass": 83869.0 }, "refseq": {}, "gene_names": [ { "name": "MEFV", "type": "recommended", "evidence": [ { "id": "E1B7P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7P5" } ] } ], "protein_names": [ { "name": "Pyrin", "type": "recommended", "evidence": [ { "id": "E1B7P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7P5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7P5", "url": "https://www.uniprot.org/uniprotkb/E1B7P5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEFV", "url": "https://www.uniprot.org/uniprotkb/E1B7P5", "locus": { "chromosome": "25", "start_pos": 2696315, "end_pos": 2707591, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019123", "url": "https://www.ensembl.org/id/ENSBTAG00000019123" } ] } } ], "crossref": [ { "id": "E1B7P5", "url": "https://alphafold.ebi.ac.uk/entry/E1B7P5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019123", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019123", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08321", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08321", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19771", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19771", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B7P5", "url": "https://www.uniprot.org/uniprotkb/E1B7P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7P5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7P5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRTRSDHLLYSLEELLPYDFEKFKFKLQNTSLEKEHLRIPRGQLQTAEPVKLASLMVNHYGEEYAVQLTLQVLRAINQHLLAEELHQVISPGNSAMSGSSGEMKPKSLKTPDGLEGDKQRQSADGAGCPPSSQPGAGSPPSSQPEAGRGPQKKPLGKQRDQKGSEGLEVQSKLGAKNTTLSSKRSPFLTKVPREKEKGSCPSVRLRRNASSAGRLQGLTSGSLAGSPGRKETKISEVYLPSGKKRPKSLELTISPEETGPLNPEILLLQEKMNTENPSSATTASEVATLKTGPTVTLEKGFRNPGHATTLEGTALRNTPLSVPLAGKMMIGEHLEPTAPSERSGTGAPKASSVPHEPSDPEVSPSSGKKGPQGPEDLVSLGMMTGAGRLQDKAVCPLCRAQEGDPVGGSCVHISCSCSAASRDPEASLSRSSSCPRCQDLLPGKSHGSHECLPQCKRHMKQAQLLFCEDHGELICLICRLSQEHRGHRVRPIEEAALEYKEQIQKQLDHLKELRKSGEEQRSQGDKKTVNSLKQAETQKQRIQYQLEQLCQFLEQQERLFVAWLEELGQTIGQVRETYGTQRTRDIALLDKLIGELEAKQCQPEWELMKPSFANGLFASRAKMVTVPELWATPPEVKEKIHLLYQKSEFVEKRVKHFLGRWACRRMGGAPSPAFKSHVARTPWRPFSIFLVLSDSAFTLACWVPARSPSAFLKKDPVHVSWMWGKPCGDVVHGPEVRNSVLSAVNVILEAETVHSNLIFHLL", "length": 763, "header": "tr|E1B7P5-1|E1B7P5_BOVIN Isoform 1 of Pyrin OS=Bos taurus OX=9913 GN=MEFV PE=4 SV=5 CANONICAL=E1B7P5-1" }, "isoforms": [ { "isoform_ac": "E1B7P5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7P5/entry", "sequence": { "sequence": "MVRTRSDHLLYSLEELLPYDFEKFKFKLQNTSLEKEHLRIPRGQLQTAEPVKLASLMVNHYGEEYAVQLTLQVLRAINQHLLAEELHQVISPGNSAMSGSSGEMKPKSLKTPDGLEGDKQRQSADGAGCPPSSQPGAGSPPSSQPEAGRGPQKKPLGKQRDQKGSEGLEVQSKLGAKNTTLSSKRSPFLTKVPREKEKGSCPSVRLRRNASSAGRLQGLTSGSLAGSPGRKETKISEVYLPSGKKRPKSLELTISPEETGPLNPEILLLQEKMNTENPSSATTASEVATLKTGPTVTLEKGFRNPGHATTLEGTALRNTPLSVPLAGKMMIGEHLEPTAPSERSGTGAPKASSVPHEPSDPEVSPSSGKKGPQGPEDLVSLGMMTGAGRLQDKAVCPLCRAQEGDPVGGSCVHISCSCSAASRDPEASLSRSSSCPRCQDLLPGKSHGSHECLPQCKRHMKQAQLLFCEDHGELICLICRLSQEHRGHRVRPIEEAALEYKEQIQKQLDHLKELRKSGEEQRSQGDKKTVNSLKQAETQKQRIQYQLEQLCQFLEQQERLFVAWLEELGQTIGQVRETYGTQRTRDIALLDKLIGELEAKQCQPEWELMKPSFANGLFASRAKMVTVPELWATPPEVKEKIHLLYQKSEFVEKRVKHFLGRWACRRMGGAPSPAFKSHVARTPWRPFSIFLVLSDSAFTLACWVPARSPSAFLKKDPVHVSWMWGKPCGDVVHGPEVRNSVLSAVNVILEAETVHSNLIFHLL", "length": 763, "header": "tr|E1B7P5-1|E1B7P5_BOVIN Isoform 1 of Pyrin OS=Bos taurus OX=9913 GN=MEFV PE=4 SV=5 CANONICAL=E1B7P5-1" }, "locus": { "chromosome": "25", "start_pos": 2708059, "end_pos": 2696113, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025458.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025458.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025458.8", "url": "https://www.ensembl.org/id/ENSBTAP00000025458.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 295, "start_aa": "Thr", "end_pos": 295, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr295", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7P5", "url": "https://www.uniprot.org/uniprotkb/E1B7P5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7P5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 763, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7P5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7P5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7P5" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 456, "end_pos": 493, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7P5" }, { "id": "PS50824", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50824" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pyrin", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 92, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 295 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 178, "end_pos": 180 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7R2-1", "uniprot_ac": "E1B7R2", "uniprot_id": "E1B7R2_BOVIN", "mass": { "chemical_mass": 65918.0, "monoisotopic_mass": 65918.0 }, "refseq": {}, "gene_names": [ { "name": "FAM227A", "type": "recommended", "evidence": [ { "id": "E1B7R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R2" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 227 member A", "type": "synonym", "evidence": [ { "id": "E1B7R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7R2", "url": "https://www.uniprot.org/uniprotkb/E1B7R2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM227A", "url": "https://www.uniprot.org/uniprotkb/E1B7R2", "locus": { "chromosome": "5", "start_pos": 110243574, "end_pos": 110294561, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010573", "url": "https://www.ensembl.org/id/ENSBTAG00000010573" } ] } } ], "crossref": [ { "id": "E1B7R2", "url": "https://alphafold.ebi.ac.uk/entry/E1B7R2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010573", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010573", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33560", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33560", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33560:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33560:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14922", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14922", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B7R2", "url": "https://www.uniprot.org/uniprotkb/E1B7R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7R2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARFRRLEVVNLTALPMVPLDEPLGVSLMAQNALKDAMRKNLKDNVPSCLVGSIQQVNQVIADADLSPNPLVHSLAIEKYEMEKKALKRERSRGGLADREKSEGKSQYICKGSEFRNVKSFVIKRKTADKNLLAELYQYPSFDDSRPNNLPNGVDFCDLVGNVILAEKNPLSGKSFCSGRELEKFLSSPSVRAIWLDSFWWIFHERYQPKKEVQSKLFDRIAQNYAFLLFCESRTHYEEALLKRLPSLLSKALYTSFCCCFPQSWFNTHEFKSDICNTMSLWISGIYPCPHSYNSWDYSKLDPERFRREELMFQRRRLLKGRDMSFLTARRHSVWKATQNRRTCCHHSADMNSSNERASSAQKNSADGPKEHTYQTLVLRRPTKQVKRISAARELESMVPKQSYPACKSPPLTPNLFNIYGKSPLIVYFLLNYSTLQQHGQDVLMVRRERTKTISESTLTYAEVINLTLSNMKKRRENFHQLNWLHWSEWNYFDEYLKELQDNFLREVKNIDQRAKDKKKANHMFIQASTFLEDTPEKKSREGKGREGWRMETEFDLFLLTIKH", "length": 564, "header": "tr|E1B7R2-1|E1B7R2_BOVIN Isoform 1 of Family with sequence similarity 227 member A OS=Bos taurus OX=9913 GN=FAM227A PE=3 SV=4 CANONICAL=E1B7R2-1" }, "isoforms": [ { "isoform_ac": "E1B7R2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R2/entry", "sequence": { "sequence": "MARFRRLEVVNLTALPMVPLDEPLGVSLMAQNALKDAMRKNLKDNVPSCLVGSIQQVNQVIADADLSPNPLVHSLAIEKYEMEKKALKRERSRGGLADREKSEGKSQYICKGSEFRNVKSFVIKRKTADKNLLAELYQYPSFDDSRPNNLPNGVDFCDLVGNVILAEKNPLSGKSFCSGRELEKFLSSPSVRAIWLDSFWWIFHERYQPKKEVQSKLFDRIAQNYAFLLFCESRTHYEEALLKRLPSLLSKALYTSFCCCFPQSWFNTHEFKSDICNTMSLWISGIYPCPHSYNSWDYSKLDPERFRREELMFQRRRLLKGRDMSFLTARRHSVWKATQNRRTCCHHSADMNSSNERASSAQKNSADGPKEHTYQTLVLRRPTKQVKRISAARELESMVPKQSYPACKSPPLTPNLFNIYGKSPLIVYFLLNYSTLQQHGQDVLMVRRERTKTISESTLTYAEVINLTLSNMKKRRENFHQLNWLHWSEWNYFDEYLKELQDNFLREVKNIDQRAKDKKKANHMFIQASTFLEDTPEKKSREGKGREGWRMETEFDLFLLTIKH", "length": 564, "header": "tr|E1B7R2-1|E1B7R2_BOVIN Isoform 1 of Family with sequence similarity 227 member A OS=Bos taurus OX=9913 GN=FAM227A PE=3 SV=4 CANONICAL=E1B7R2-1" }, "locus": { "chromosome": "5", "start_pos": 110287563, "end_pos": 110243577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013979.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013979.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013979.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013979.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7R2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 564, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7R2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7R2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 466, "end_pos": 468 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7V3-1", "uniprot_ac": "E1B7V3", "uniprot_id": "E1B7V3_BOVIN", "mass": { "chemical_mass": 20558.0, "monoisotopic_mass": 20558.0 }, "refseq": { "ac": "XP_059741122", "name": "protein shisa-like-2A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741122" }, "gene_names": [ { "name": "SHISAL2A", "type": "recommended", "evidence": [ { "id": "E1B7V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V3" } ] }, { "name": "SHISAL2A", "type": "synonym", "evidence": [ { "id": "XP_059741122", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741122" } ] } ], "protein_names": [ { "name": "Shisa like 2A", "type": "synonym", "evidence": [ { "id": "E1B7V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V3/entry#names_and_taxonomy" } ] }, { "name": "protein shisa-like-2A", "type": "synonym", "evidence": [ { "id": "XP_059741122", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741122" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7V3", "url": "https://www.uniprot.org/uniprotkb/E1B7V3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHISAL2A", "url": "https://www.uniprot.org/uniprotkb/E1B7V3", "locus": { "chromosome": "3", "start_pos": 93695614, "end_pos": 93727106, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044107", "url": "https://www.ensembl.org/id/ENSBTAG00000044107" } ] } } ], "crossref": [ { "id": "E1B7V3", "url": "https://alphafold.ebi.ac.uk/entry/E1B7V3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044107", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044107", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "787024", "url": "https://www.ncbi.nlm.nih.gov/gene/787024", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787024", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787024", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLLQHCF", "url": "https://omabrowser.org/oma/group/CLLQHCF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7V3", "url": "https://www.orthodb.org/?gene=E1B7V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31395", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31395:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059741122", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741122", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7V3", "url": "https://www.uniprot.org/uniprotkb/E1B7V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7V3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGACTSYVSAEQEVVRGFSCPRPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHSYMWWLSTGALVGLSIAAVVLLAFIVTACVLCYLFISSKPHTKLDPGLNLQTTDPDEAPSDCQGRNTGNSVEVRGVSPLRQSHPFLNSWLDCNEEQAKDPKRLLQHCFMATVTAGDLPRSPEEVPVPSLLYPAP", "length": 188, "header": "tr|E1B7V3-1|E1B7V3_BOVIN Isoform 1 of Shisa like 2A OS=Bos taurus OX=9913 GN=SHISAL2A PE=4 SV=1 CANONICAL=E1B7V3-1" }, "isoforms": [ { "isoform_ac": "E1B7V3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V3/entry", "sequence": { "sequence": "MSGACTSYVSAEQEVVRGFSCPRPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHSYMWWLSTGALVGLSIAAVVLLAFIVTACVLCYLFISSKPHTKLDPGLNLQTTDPDEAPSDCQGRNTGNSVEVRGVSPLRQSHPFLNSWLDCNEEQAKDPKRLLQHCFMATVTAGDLPRSPEEVPVPSLLYPAP", "length": 188, "header": "tr|E1B7V3-1|E1B7V3_BOVIN Isoform 1 of Shisa like 2A OS=Bos taurus OX=9913 GN=SHISAL2A PE=4 SV=1 CANONICAL=E1B7V3-1" }, "locus": { "chromosome": "3", "start_pos": 93726907, "end_pos": 93695641, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061156.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061156.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053173.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053173.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787024", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787024", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2A9G7-1", "protein_name": "Protein shisa-like-2A", "gene_name": "Shisal2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGACSSYVSAEQEVVRGFSCPLPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHNYMWWLSIGALVGLSTAAVVLLAFLITACVLCYLFISSKPQTKLDPGLSLQTTGSKEMSPDHHGLNTAIPMEVPGVSSPRQSSSSNTHLESNKKQTVSPTCLPQNQFMATVTASNIPGSPDEISVPTPGPHGPVP", "length": 189 }, "evidence": [ { "id": "E1B7V3", "url": "https://omabrowser.org/oma/group/E1B7V3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZEV9-1", "protein_name": "Shisa like 2A", "gene_name": "Shisal2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGACSSYVSAEQEVVRGFSCPLPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHNYMWWLSIGALVGLSTAAVVLLAFLITAFVLCYLFISSKPHTKLDPGLSLQTTGSKEMSPDHQGLNTAIMMEVPGVSSPRQSSSLNTRLESNERQTVGPRGLLQNQFMATVTASHIPDSPEEASVPTPDPYGPAP", "length": 189 }, "evidence": [ { "id": "E1B7V3", "url": "https://omabrowser.org/oma/group/E1B7V3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UWV7-1", "protein_name": "Protein shisa-like-2A", "gene_name": "SHISAL2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGACTSYVSAEQEVVRGFSCPRPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHSYMWWLSIGALIGLSVAAVVLLAFIVTACVLCYLFISSKPHTKLDLGLSLQTAGPEEVSPDCQGVNTGMAAEVPKVSPLQQSYSCLNPQLESNEGQAVNSKRLLHHCFMATVTTSDIPGSPEEASVPNPDLCGPVP", "length": 190 }, "evidence": [ { "id": "E1B7V3", "url": "https://omabrowser.org/oma/group/E1B7V3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7V3", "url": "https://www.uniprot.org/uniprotkb/E1B7V3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7V3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 188, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7V3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7V3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V3" }, { "id": "PF13908", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shisa N-terminal", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 48, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7W2-1", "uniprot_ac": "E1B7W2", "uniprot_id": "E1B7W2_BOVIN", "mass": { "chemical_mass": 38449.0, "monoisotopic_mass": 38449.0 }, "refseq": {}, "gene_names": [ { "name": "C2H2orf72", "type": "recommended", "evidence": [ { "id": "E1B7W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7W2" } ] } ], "protein_names": [ { "name": "Chromosome 2 C2orf72 homolog", "type": "synonym", "evidence": [ { "id": "E1B7W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7W2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7W2", "url": "https://www.uniprot.org/uniprotkb/E1B7W2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C2H2orf72", "url": "https://www.uniprot.org/uniprotkb/E1B7W2", "locus": { "chromosome": "2", "start_pos": 118855036, "end_pos": 118846590, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026710", "url": "https://www.ensembl.org/id/ENSBTAG00000026710" } ] } } ], "crossref": [ { "id": "E1B7W2", "url": "https://alphafold.ebi.ac.uk/entry/E1B7W2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026710", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026710", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B7W2", "url": "https://www.orthodb.org/?gene=E1B7W2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35675:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35675:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B7W2", "url": "https://www.uniprot.org/uniprotkb/E1B7W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7W2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7W2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNEPLSFPLSATRGTSGGATLRELVGRKPPPSSRLKLGNPARGPGVGQGAALEACPPRPGAAAPRGGQLARQGRSGRRGRAAASMERELEALAARPESPGEPPFQALVEAAGGRGQVLLVGELWEREQSRALLWDFARAMFPPQQAAGKPGGGAAEGAGPGAPRAPKRHATGARAIRSPLVFVLCRASSLAARGPRRHLREMLRDVRGRRRAGAALVGVLVAEAEPEDAVAPELRLLEALLRTVFGRQAGGPVQAAAYRPGQPGSSLAVQAAACRALQAAGPWQPAEGAWERPGLPALLACFSWGPWSRGKNPDTSSRSGPAQGDLRDSEEELVLTAVYPNGDCEDPGEGSEPCDRIASAPTEPAGDLR", "length": 370, "header": "tr|E1B7W2-1|E1B7W2_BOVIN Isoform 1 of Chromosome 2 C2orf72 homolog OS=Bos taurus OX=9913 GN=C2H2orf72 PE=4 SV=3 CANONICAL=E1B7W2-1" }, "isoforms": [ { "isoform_ac": "E1B7W2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7W2/entry", "sequence": { "sequence": "MLNEPLSFPLSATRGTSGGATLRELVGRKPPPSSRLKLGNPARGPGVGQGAALEACPPRPGAAAPRGGQLARQGRSGRRGRAAASMERELEALAARPESPGEPPFQALVEAAGGRGQVLLVGELWEREQSRALLWDFARAMFPPQQAAGKPGGGAAEGAGPGAPRAPKRHATGARAIRSPLVFVLCRASSLAARGPRRHLREMLRDVRGRRRAGAALVGVLVAEAEPEDAVAPELRLLEALLRTVFGRQAGGPVQAAAYRPGQPGSSLAVQAAACRALQAAGPWQPAEGAWERPGLPALLACFSWGPWSRGKNPDTSSRSGPAQGDLRDSEEELVLTAVYPNGDCEDPGEGSEPCDRIASAPTEPAGDLR", "length": 370, "header": "tr|E1B7W2-1|E1B7W2_BOVIN Isoform 1 of Chromosome 2 C2orf72 homolog OS=Bos taurus OX=9913 GN=C2H2orf72 PE=4 SV=3 CANONICAL=E1B7W2-1" }, "locus": { "chromosome": "2", "start_pos": 118854032, "end_pos": 118846789, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038103.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038103.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037919.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037919.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7W2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7W2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7W2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7W2" }, { "id": "PF15443", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15443" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2orf72-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 368, "start_aa": "Gly", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7Y0-1", "uniprot_ac": "E1B7Y0", "uniprot_id": "E1B7Y0_BOVIN", "mass": { "chemical_mass": 15930.0, "monoisotopic_mass": 15930.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM207", "type": "recommended", "evidence": [ { "id": "E1B7Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0" } ] } ], "protein_names": [ { "name": "Transmembrane protein 207", "type": "synonym", "evidence": [ { "id": "E1B7Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Y0", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM207", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0", "locus": { "chromosome": "1", "start_pos": 76815563, "end_pos": 76794972, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013456", "url": "https://www.ensembl.org/id/ENSBTAG00000013456" } ] } } ], "crossref": [ { "id": "E1B7Y0", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Y0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR039490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B7Y0", "url": "https://www.orthodb.org/?gene=E1B7Y0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36467", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36467", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36467:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36467:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1B7Y0", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Y0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSRLLSDASVISKAGILCLPLFQLVLSDTPCEENEMCINYKDHYTNGWYIWFLLLIFLVALLCGTVIFCFQCCLRRLKNGPRRRTMAVFAVGDLDSVCGTEAAVTPTVGMHLHTQNPELFRAPCFGVLGPPPPYEEKSSR", "length": 142, "header": "tr|E1B7Y0-1|E1B7Y0_BOVIN Isoform 1 of Transmembrane protein 207 OS=Bos taurus OX=9913 GN=TMEM207 PE=4 SV=3 CANONICAL=E1B7Y0-1" }, "isoforms": [ { "isoform_ac": "E1B7Y0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0/entry", "sequence": { "sequence": "MLRSRLLSDASVISKAGILCLPLFQLVLSDTPCEENEMCINYKDHYTNGWYIWFLLLIFLVALLCGTVIFCFQCCLRRLKNGPRRRTMAVFAVGDLDSVCGTEAAVTPTVGMHLHTQNPELFRAPCFGVLGPPPPYEEKSSR", "length": 142, "header": "tr|E1B7Y0-1|E1B7Y0_BOVIN Isoform 1 of Transmembrane protein 207 OS=Bos taurus OX=9913 GN=TMEM207 PE=4 SV=3 CANONICAL=E1B7Y0-1" }, "locus": { "chromosome": "1", "start_pos": 76815563, "end_pos": 76794972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017899.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017899.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017899.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017899.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 109, "start_aa": "Thr", "end_pos": 109, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr109", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y0", "url": "https://www.uniprot.org/uniprotkb/E1B7Y0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Y0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Y0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Y0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 109 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7Y5-1", "uniprot_ac": "E1B7Y5", "uniprot_id": "E1B7Y5_BOVIN", "mass": { "chemical_mass": 34996.0, "monoisotopic_mass": 34996.0 }, "refseq": { "ac": "NP_001377190", "name": "olfactory receptor family 6 subfamily D member 16", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377190" }, "gene_names": [ { "name": "OR6D16", "type": "recommended", "evidence": [ { "id": "E1B7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5" } ] }, { "name": "OR6D16", "type": "synonym", "evidence": [ { "id": "NP_001377190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377190" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 6 subfamily D member 16", "type": "synonym", "evidence": [ { "id": "E1B7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 6C75", "type": "synonym", "evidence": [ { "id": "NP_001377190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377190" } ] }, { "name": "olfactory receptor family 6 subfamily D member 16", "type": "synonym", "evidence": [ { "id": "NP_001377190", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377190" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377190" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y5", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Y5", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6D16", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5", "locus": { "chromosome": "28", "start_pos": 44449676, "end_pos": 44448732, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009763", "url": "https://www.ensembl.org/id/ENSBTAG00000009763" } ] } } ], "crossref": [ { "id": "E1B7Y5", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Y5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009763", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009763", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618139", "url": "https://www.ncbi.nlm.nih.gov/gene/618139", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618139", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618139", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377190", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7Y5", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Y5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGDARNRTAAPEFMLEGFPAVQHLGKVLFSVHLLMYLASVAGNTLIITITWADHHLQTPMYFFLSSFSFLECCFTTTVIPKLLAIFLLGRQKISFAACITQAFVFLFLGATVFFLMAVLSLDRYMAICKPLYYPTIMNPRMCSLLVSACLVLGFSLMVVPVTKLSQLFFCGSHVIPHFFCDLGPLINLSCSDIRSIEMLAFGLALFILSTSFIITIISYSNIVVTILHLPSAKERQKAFSTCSSHFIVLSLMYGSCVFIYMKPKGTNQLDSNKGAALVNTVVTPLLNPVIYTLRNKQVHQALRNALTRVRLQK", "length": 314, "header": "tr|E1B7Y5-1|E1B7Y5_BOVIN Isoform 1 of Olfactory receptor family 6 subfamily D member 16 OS=Bos taurus OX=9913 GN=OR6D16 PE=3 SV=3 CANONICAL=E1B7Y5-1" }, "isoforms": [ { "isoform_ac": "E1B7Y5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5/entry", "sequence": { "sequence": "MNGDARNRTAAPEFMLEGFPAVQHLGKVLFSVHLLMYLASVAGNTLIITITWADHHLQTPMYFFLSSFSFLECCFTTTVIPKLLAIFLLGRQKISFAACITQAFVFLFLGATVFFLMAVLSLDRYMAICKPLYYPTIMNPRMCSLLVSACLVLGFSLMVVPVTKLSQLFFCGSHVIPHFFCDLGPLINLSCSDIRSIEMLAFGLALFILSTSFIITIISYSNIVVTILHLPSAKERQKAFSTCSSHFIVLSLMYGSCVFIYMKPKGTNQLDSNKGAALVNTVVTPLLNPVIYTLRNKQVHQALRNALTRVRLQK", "length": 314, "header": "tr|E1B7Y5-1|E1B7Y5_BOVIN Isoform 1 of Olfactory receptor family 6 subfamily D member 16 OS=Bos taurus OX=9913 GN=OR6D16 PE=3 SV=3 CANONICAL=E1B7Y5-1" }, "locus": { "chromosome": "28", "start_pos": 44449673, "end_pos": 44448732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052182.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052182.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052201.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052201.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618139", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618139", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y5", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y5", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7Y5", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Y5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Y5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Y5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Y5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 292, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7Z5-1", "uniprot_ac": "E1B7Z5", "uniprot_id": "E1B7Z5_BOVIN", "mass": { "chemical_mass": 76952.0, "monoisotopic_mass": 76952.0 }, "refseq": { "ac": "XP_024844521", "name": "PWWP domain-containing DNA repair factor 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844521" }, "gene_names": [ { "name": "PWWP4", "type": "recommended", "evidence": [ { "id": "E1B7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5" } ] }, { "name": "PWWP4", "type": "synonym", "evidence": [ { "id": "XP_024844521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844521" } ] } ], "protein_names": [ { "name": "PWWP domain containing 3A, DNA repair factor", "type": "recommended", "evidence": [ { "id": "E1B7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5/entry#names_and_taxonomy" } ] }, { "name": "PWWP domain-containing DNA repair factor 4", "type": "synonym", "evidence": [ { "id": "XP_024844521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844521" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Z5", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PWWP4", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5", "locus": {} } ], "crossref": [ { "id": "E1B7Z5", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Z5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023820", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023820", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06080", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06080", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615782", "url": "https://www.ncbi.nlm.nih.gov/gene/615782", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR035504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31333:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31333:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20887", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20887", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844521", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844521", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7Z5", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Z5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTRYVLCVWKGRFWPAKVLSRPSVSPQQKRKRALSLEVQILSIDEKIRVKKTKIKTLKESMIESISTSLAAQPEPIAPEEEEMAYICAITMAWDVLNKNGNFTPARVAGDPESKMQSPRRLQKQHCRRCQKPKRGLRRSVRKSKSSKSPVVPSEREDGPYGDKPQVCTPIAPIPTEMQTESSQSSGVHPSFLSLSEDDREKEGKEKQDASKVMSLPCTVKEVGVDVRGERVLPSLTPGFILTVPKAPEEGVHNTCPKSLAVSPERATSSVNVDPEEGTCNSGSEGAEASSNASNLGLRYSLCLANRKRKLQAPGCEEEQQESQPSAGSKAIKPTSAIKKGGGKEVGQLTSMACPEELCPIERGMLVWFKFQNHPFWPAVVKSVSPTEQTARVLLIEANMHCEKSGIQVPLRRLKHLDYNGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADISYPMRKAIQEGDLQMDFPKVNYSDLEDSEEETPVAAKRHCKRILPDRMRAAWDRANEKLVDFIVNRKGADPHLLDIVKGRKESKWLESFLHSERYVICVETYLEDDDQLDAVVRHLQEIYKHIDKKALALTRDDPVSFLLEVLLPEAIICSIATMDGLDYKEAEAKYRQGPPVRYREKELFDKKILKKIKKRSAERYKAKLSPCAQQGIGQASRPHH", "length": 685, "header": "tr|E1B7Z5-1|E1B7Z5_BOVIN Isoform 1 of PWWP domain containing 3A, DNA repair factor OS=Bos taurus OX=9913 GN=PWWP4 PE=3 SV=5 CANONICAL=E1B7Z5-1" }, "isoforms": [ { "isoform_ac": "E1B7Z5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5/entry", "sequence": { "sequence": "MDTRYVLCVWKGRFWPAKVLSRPSVSPQQKRKRALSLEVQILSIDEKIRVKKTKIKTLKESMIESISTSLAAQPEPIAPEEEEMAYICAITMAWDVLNKNGNFTPARVAGDPESKMQSPRRLQKQHCRRCQKPKRGLRRSVRKSKSSKSPVVPSEREDGPYGDKPQVCTPIAPIPTEMQTESSQSSGVHPSFLSLSEDDREKEGKEKQDASKVMSLPCTVKEVGVDVRGERVLPSLTPGFILTVPKAPEEGVHNTCPKSLAVSPERATSSVNVDPEEGTCNSGSEGAEASSNASNLGLRYSLCLANRKRKLQAPGCEEEQQESQPSAGSKAIKPTSAIKKGGGKEVGQLTSMACPEELCPIERGMLVWFKFQNHPFWPAVVKSVSPTEQTARVLLIEANMHCEKSGIQVPLRRLKHLDYNGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADISYPMRKAIQEGDLQMDFPKVNYSDLEDSEEETPVAAKRHCKRILPDRMRAAWDRANEKLVDFIVNRKGADPHLLDIVKGRKESKWLESFLHSERYVICVETYLEDDDQLDAVVRHLQEIYKHIDKKALALTRDDPVSFLLEVLLPEAIICSIATMDGLDYKEAEAKYRQGPPVRYREKELFDKKILKKIKKRSAERYKAKLSPCAQQGIGQASRPHH", "length": 685, "header": "tr|E1B7Z5-1|E1B7Z5_BOVIN Isoform 1 of PWWP domain containing 3A, DNA repair factor OS=Bos taurus OX=9913 GN=PWWP4 PE=3 SV=5 CANONICAL=E1B7Z5-1" }, "locus": { "chromosome": "X", "start_pos": 36467093, "end_pos": 36465039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032692.7", "url": "https://www.ensembl.org/id/ENSBTAT00000032692.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032621.7", "url": "https://www.ensembl.org/id/ENSBTAP00000032621.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 335, "start_aa": "Thr", "end_pos": 335, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr335", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Z5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 685, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Z5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Z5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5" }, { "id": "PF20884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MUM1-like PWWP", "eco_id": "ECO_0000259", "start_pos": 362, "end_pos": 440, "start_aa": "Glu", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z5" }, { "id": "PF20887", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20887" }, { "id": "PF20886", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20886" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PWWP", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 99, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 335 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 489, "end_pos": 491 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B812-1", "uniprot_ac": "E1B812", "uniprot_id": "E1B812_BOVIN", "mass": { "chemical_mass": 65399.0, "monoisotopic_mass": 65399.0 }, "refseq": {}, "gene_names": [ { "name": "HSF5", "type": "recommended", "evidence": [ { "id": "E1B812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ] } ], "protein_names": [ { "name": "Heat shock factor protein 5", "type": "recommended", "evidence": [ { "id": "E1B812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B812/entry#names_and_taxonomy" } ] }, { "name": "Heat shock transcription factor 5", "type": "synonym", "evidence": [ { "id": "E1B812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B812/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions. Positvely and negatively regulates gene expression to ensure progression of meiotic prophase beyond pachytene stage in spermatocytes.", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812#function" }, { "database": "UniProtKB", "id": "ARBA00094520", "url": "https://www.uniprot.org/uniprotkb/ARBA00094520#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSF5", "url": "https://www.uniprot.org/uniprotkb/E1B812", "locus": { "chromosome": "19", "start_pos": 9392889, "end_pos": 9447565, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001166", "url": "https://www.ensembl.org/id/ENSBTAG00000001166" } ] } } ], "crossref": [ { "id": "E1B812", "url": "https://alphafold.ebi.ac.uk/entry/E1B812", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001166", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001166", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000232", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000232", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10015:SF278", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10015:SF278", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00447", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00447", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B812-1", "url": "https://www.uniprot.org/uniprotkb/E1B812-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQPLFEAELLSPPGAGAGGGGAGGAGGGGGVGGAGAEPELFKTTNFTSFIRQLNLYGFRKVVLGGPGAAGPGPGPGGGGPAGDGPLHHFHSPHFRRDQPQLLVHLKRLTSANKAKLAAGLEVPCRPPNRFQRLLITSASASASTSPLQHQEPPLPPSGPRPEPQGPVAVGQFHRSFRRDSLSPYSYVSTSSHNHSTFPLKGLDRTPIPPRTWQNSLGMHPGQVETSPTFSDKGVPFPVLQRFPTEVTYTLQPSATSVHVQQGPQTMVSSSQKYSNYTPSAQYSQAYYPTAVLQCCSPPTRMDALSSCVTPPAASYAHCSYFQNPPMQSSYPVEFLPSNWPCSATDENKKTEVNLEAVFQIVDELHSSPKLEMVKVEPVENQCSTSQSNRSQHILANSNNSNPSSTSQASQLEPLTPVGSDITSFVVGTEQAITSSLPQSPEYIYTIHPAQPVENTTMQESAINQQAHIKLKEQLSHNPSASSVVFVQEGLPFSTHQMDASIKCQTSPPENILPSEQMGFLISEMGPASKPSKDMSLSTPARYRERRSNSQQGKSPGKDCCALECSQ", "length": 608, "header": "tr|E1B812-1|E1B812_BOVIN Isoform 1 of Heat shock factor protein 5 OS=Bos taurus OX=9913 GN=HSF5 PE=3 SV=5 CANONICAL=E1B812-1" }, "isoforms": [ { "isoform_ac": "E1B812-1", "url": "https://www.uniprot.org/uniprotkb/E1B812/entry", "sequence": { "sequence": "MEEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQPLFEAELLSPPGAGAGGGGAGGAGGGGGVGGAGAEPELFKTTNFTSFIRQLNLYGFRKVVLGGPGAAGPGPGPGGGGPAGDGPLHHFHSPHFRRDQPQLLVHLKRLTSANKAKLAAGLEVPCRPPNRFQRLLITSASASASTSPLQHQEPPLPPSGPRPEPQGPVAVGQFHRSFRRDSLSPYSYVSTSSHNHSTFPLKGLDRTPIPPRTWQNSLGMHPGQVETSPTFSDKGVPFPVLQRFPTEVTYTLQPSATSVHVQQGPQTMVSSSQKYSNYTPSAQYSQAYYPTAVLQCCSPPTRMDALSSCVTPPAASYAHCSYFQNPPMQSSYPVEFLPSNWPCSATDENKKTEVNLEAVFQIVDELHSSPKLEMVKVEPVENQCSTSQSNRSQHILANSNNSNPSSTSQASQLEPLTPVGSDITSFVVGTEQAITSSLPQSPEYIYTIHPAQPVENTTMQESAINQQAHIKLKEQLSHNPSASSVVFVQEGLPFSTHQMDASIKCQTSPPENILPSEQMGFLISEMGPASKPSKDMSLSTPARYRERRSNSQQGKSPGKDCCALECSQ", "length": 608, "header": "tr|E1B812-1|E1B812_BOVIN Isoform 1 of Heat shock factor protein 5 OS=Bos taurus OX=9913 GN=HSF5 PE=3 SV=5 CANONICAL=E1B812-1" }, "locus": { "chromosome": "19", "start_pos": 9444445, "end_pos": 9420609, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001549.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001549.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001549.8", "url": "https://www.ensembl.org/id/ENSBTAP00000001549.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" }, { "name": "XY body", "id": "GO:0001741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity", "id": "GO:0001216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001216", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity", "id": "GO:0001217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001217", "evidence": [ { "database": "UniProtKB", "id": "E1B812", "url": "https://www.uniprot.org/uniprotkb/E1B812" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B812-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 608, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B812-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B812" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B812" }, { "id": "SM00415", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00415" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HSF-type DNA-binding", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 150, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 440, "end_pos": 442 }, { "start_pos": 496, "end_pos": 498 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B846-1", "uniprot_ac": "E1B846", "uniprot_id": "E1B846_BOVIN", "mass": { "chemical_mass": 67747.0, "monoisotopic_mass": 67747.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100297513", "type": "recommended", "evidence": [ { "id": "E1B846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B846" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 170", "type": "recommended", "evidence": [ { "id": "E1B846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B846/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B846", "url": "https://www.uniprot.org/uniprotkb/E1B846" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100297513", "url": "https://www.uniprot.org/uniprotkb/E1B846", "locus": {} } ], "crossref": [ { "id": "E1B846", "url": "https://alphafold.ebi.ac.uk/entry/E1B846", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013836", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013836", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR039139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR18863", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18863", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18863:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18863:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1B846", "url": "https://www.uniprot.org/uniprotkb/E1B846", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B846-1", "url": "https://www.uniprot.org/uniprotkb/E1B846-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSPVQFLNHSNPGKLATAQSKGPRKAKPLEVKHISAYASRKNSSGACLNPPIEVVPTRNPVKCNKRAADSVHPDLAGLLVKNKNLLAELRNLRNKLLIKETSLQEMKSELETYKENNVQQSFQIMSLKDDIKDLEELIASLTRIKSLKNTSIQSLERGNWDLTERITELENLLRVHLIERKRAERKADLLEKKLAGANRFSPYMSMKEQEDSLDSFMTKDKDEAILVKNFERDNTFCSEGPKDGQKIWDKCQQDLIHEEKQILELDRPPRSYNWETKIARSHYQKFLSQLSALPSNSAEPTPAIEEAVKESLLETGANEQSWKSRAEVLQQEMQMLTKRLEKQSHHSEETAGEVSDTEEKYMEQKRLLKCLEGKIHSFFVSILLISVKENSQSKISQVDEHGKTFEQLEKDNKQETLLNIQQNFQTVTTQRLEEKIQKLQKQLSDLKLSNKNMKTQLTRVNVLKDKTIEKLRESLTKVEAMKGKAVMETDLKTTVDSDEQEARWDKKKIHQVLETATPELSTAKSTLEEVPGKQEKLVDFRETIMKMLGFNMKTADKKIINHLRLIIQVYEASDKSKMASECETGQDNE", "length": 590, "header": "tr|E1B846-1|E1B846_BOVIN Isoform 1 of Coiled-coil domain containing 170 OS=Bos taurus OX=9913 GN=LOC100297513 PE=4 SV=4 CANONICAL=E1B846-1" }, "isoforms": [ { "isoform_ac": "E1B846-1", "url": "https://www.uniprot.org/uniprotkb/E1B846/entry", "sequence": { "sequence": "MSSPVQFLNHSNPGKLATAQSKGPRKAKPLEVKHISAYASRKNSSGACLNPPIEVVPTRNPVKCNKRAADSVHPDLAGLLVKNKNLLAELRNLRNKLLIKETSLQEMKSELETYKENNVQQSFQIMSLKDDIKDLEELIASLTRIKSLKNTSIQSLERGNWDLTERITELENLLRVHLIERKRAERKADLLEKKLAGANRFSPYMSMKEQEDSLDSFMTKDKDEAILVKNFERDNTFCSEGPKDGQKIWDKCQQDLIHEEKQILELDRPPRSYNWETKIARSHYQKFLSQLSALPSNSAEPTPAIEEAVKESLLETGANEQSWKSRAEVLQQEMQMLTKRLEKQSHHSEETAGEVSDTEEKYMEQKRLLKCLEGKIHSFFVSILLISVKENSQSKISQVDEHGKTFEQLEKDNKQETLLNIQQNFQTVTTQRLEEKIQKLQKQLSDLKLSNKNMKTQLTRVNVLKDKTIEKLRESLTKVEAMKGKAVMETDLKTTVDSDEQEARWDKKKIHQVLETATPELSTAKSTLEEVPGKQEKLVDFRETIMKMLGFNMKTADKKIINHLRLIIQVYEASDKSKMASECETGQDNE", "length": 590, "header": "tr|E1B846-1|E1B846_BOVIN Isoform 1 of Coiled-coil domain containing 170 OS=Bos taurus OX=9913 GN=LOC100297513 PE=4 SV=4 CANONICAL=E1B846-1" }, "locus": { "chromosome": "10", "start_pos": 76538495, "end_pos": 76507880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018375.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018375.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018375.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018375.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 302, "start_aa": "Thr", "end_pos": 302, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr302", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B846-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 590, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B846-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B846" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 302 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B869-1", "uniprot_ac": "E1B869", "uniprot_id": "E1B869_BOVIN", "mass": { "chemical_mass": 41217.0, "monoisotopic_mass": 41217.0 }, "refseq": { "ac": "NP_001192381", "name": "probable methyltransferase-like protein 24 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192381" }, "gene_names": [ { "name": "METTL24", "type": "recommended", "evidence": [ { "id": "E1B869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B869" } ] }, { "name": "C9H6orf186", "type": "synonym", "evidence": [ { "id": "NP_001192381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192381" } ] }, { "name": "METTL24", "type": "synonym", "evidence": [ { "id": "NP_001192381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192381" } ] } ], "protein_names": [ { "name": "Methyltransferase like 24", "type": "synonym", "evidence": [ { "id": "E1B869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B869/entry#names_and_taxonomy" } ] }, { "name": "probable methyltransferase-like protein 24 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192381" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B869", "url": "https://www.uniprot.org/uniprotkb/E1B869" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL24", "url": "https://www.uniprot.org/uniprotkb/E1B869", "locus": { "chromosome": "9", "start_pos": 39979736, "end_pos": 39853735, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033365", "url": "https://www.ensembl.org/id/ENSBTAG00000033365" } ] } } ], "crossref": [ { "id": "E1B869", "url": "https://alphafold.ebi.ac.uk/entry/E1B869", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033365", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033365", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785203", "url": "https://www.ncbi.nlm.nih.gov/gene/785203", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785203", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785203", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TQIACDH", "url": "https://omabrowser.org/oma/group/TQIACDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B869", "url": "https://www.orthodb.org/?gene=E1B869", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32026:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32026:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192381", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B869", "url": "https://www.uniprot.org/uniprotkb/E1B869", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B869-1", "url": "https://www.uniprot.org/uniprotkb/E1B869-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARERLPGRGCCALRRCLLAAALLLGLRLCAELQRAGPQPPALSPPPGQAPRPPGSHLQPAPGQLRGASRRQVTYVRSGRRAPAGGSRSGTPEPGCCALRGRPRLKGPRWQIDLQPWAGPARSLDEEALRFLRYISTIQIECDHMSTDSLATDSSPTKKPWPVCLDDRFGLVHQIRNKQCRLYSLGLGSDDTHFEVGMASNGCEVHRFDPSVKSAHVLESERLWFHRLSIDWRDPHPAVAAQKPYGNTRKLGAILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSDSSVVRFWYSLLKELELQDFRLFHSYKDLSKPQLFLKKDIFNASSCYTLGWVNTRWK", "length": 366, "header": "tr|E1B869-1|E1B869_BOVIN Isoform 1 of Methyltransferase like 24 OS=Bos taurus OX=9913 GN=METTL24 PE=4 SV=1 CANONICAL=E1B869-1" }, "isoforms": [ { "isoform_ac": "E1B869-1", "url": "https://www.uniprot.org/uniprotkb/E1B869/entry", "sequence": { "sequence": "MARERLPGRGCCALRRCLLAAALLLGLRLCAELQRAGPQPPALSPPPGQAPRPPGSHLQPAPGQLRGASRRQVTYVRSGRRAPAGGSRSGTPEPGCCALRGRPRLKGPRWQIDLQPWAGPARSLDEEALRFLRYISTIQIECDHMSTDSLATDSSPTKKPWPVCLDDRFGLVHQIRNKQCRLYSLGLGSDDTHFEVGMASNGCEVHRFDPSVKSAHVLESERLWFHRLSIDWRDPHPAVAAQKPYGNTRKLGAILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSDSSVVRFWYSLLKELELQDFRLFHSYKDLSKPQLFLKKDIFNASSCYTLGWVNTRWK", "length": 366, "header": "tr|E1B869-1|E1B869_BOVIN Isoform 1 of Methyltransferase like 24 OS=Bos taurus OX=9913 GN=METTL24 PE=4 SV=1 CANONICAL=E1B869-1" }, "locus": { "chromosome": "9", "start_pos": 39979075, "end_pos": 39853886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047451.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047451.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044658.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044658.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785203", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785203", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BI29-1", "protein_name": "Methyltransferase like 24", "gene_name": "METTL24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAWQRPPRRGCGSLQRCLLGAALLLGLRLCAELRRASLRPPASSAPPGRAPRPPRPHLPPAPGLQRGASWRQVTYVRSGRRAPPGGGGSGTPKPCCAPHGSPRRKGPRWHIDLQPWAGPARSLDEEALRFLRYISTIQIACDHMSTDSLATDSSPTKKPWSVCLDDRFGLAHQIHSKQCRLYSLGLGSDDTRFEVGMANDGCEVHRFDPSVKSAHVLENERLWYHRLSINWRDPHPAVAAQKPYSSTRKLRTILNEFGHHKIDILKADLESAEWKVLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSDSSVVRFWYSLLKELELQDFRLFHSYKDLSKPQIFLRKNIFNASSCYTLSWVNTRWK", "length": 365 }, "evidence": [ { "id": "E1B869", "url": "https://omabrowser.org/oma/group/E1B869/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QGJ7-1", "protein_name": "Methyltransferase-like protein 24", "gene_name": "Mettl24", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATARPPGRGSGALPLWLLGAALLLGLRLCMELHRPGSGSPGRHDPPGPPRPHLLSPPDPPRGARRRQVTYVRSGRRALPRGGGTTTLEPSCCTPGGLPSRKGPRWHIELQPWAGPAQSLDEEALRFLSYISTTQIACDHMGTDSLATDSSPATKPWLVCLDDRFGLAHQIRSKQCRLYSLGLGSDDTHFEVSMANDGCEVHRFDPSVKSAHVLESQHLWHHRLSIDWRDPHPAVAAQKSHSNTRKLGSILNEFGHHKIDILKADLESAEWKVLENLILEDVLEQIGQLVFEIHLHWPGFEVSGSESSVVRFWYSLLKELEQKDFRLFHTYKDLSKPQLFLKKDIFNASSCYTLSWVNTRWK", "length": 362 }, "evidence": [ { "id": "E1B869", "url": "https://omabrowser.org/oma/group/E1B869/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YU23-1", "protein_name": "Methyltransferase like 24", "gene_name": "METTL24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKERPLWRRAAFRLCVLSAALLLCLQLAMRRSWCPEEKLRLPAVAASGRAVPQPRGTAAAPGRRRVTYVRSGRRGGRPGCCPPGRKTVRWHIELQPWASPTPSLNYEALRFLKYISTSQISCEHMNVSSLRGNSEATKRPWSVCLDERFSLIHRLRNKQCRLYSLGLGSDDNQFEISMANSGCEVHRFDPSIKSAHIQEGQHLWYHRLSVDWRDPNPAIATHKLHSNTKKLGTILNEFGHQKIDVLKADVESAEWKILENLILEDVVEQIGQLVFEVHIHWPGFEVSGNDSTVVRYWYSLLRELELKDFRLFHTYKDLLKPQMLLKKEAFNASSCYRLSWVNTRWK", "length": 347 }, "evidence": [ { "id": "E1B869", "url": "https://omabrowser.org/oma/group/E1B869/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5BK01-1", "protein_name": "Probable methyltransferase-like protein 24", "gene_name": "Mettl24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTAKPPGRGCGALPRWLLGAALLLGLRLCMELRHAGSGPPGRRDLRGPPRTHLLPAPGPLRGTRRRQVTYVRSGRRALPRGGVSTTPPEPSCCAQLGLPSRKGPRWHIELQPWAGPSRSLDEEASRFLNYIGTTQIACDRMGTNSVATDSGPALKPWLVCLDDRFGLAHQIRTKQCRLYSLGLGSDDTHFEVSMANGGCEVHRFDPSVRSAHVLQSQRLWHHRLSIDWRDPHPAVAAQKPYSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSESSVVRFWYSLLKELERKDFRLFHTYKDLSKPQLFLKKDIFNASSCYTLSWVNTRWR", "length": 363 }, "evidence": [ { "id": "E1B869", "url": "https://omabrowser.org/oma/group/E1B869/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5JXM2-1", "protein_name": "Probable methyltransferase-like protein 24", "gene_name": "METTL24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARERPPGRGCGVLRRCLLGAVLLFGLRLCAELRRAGPGSPTRSAPPGPAWRPPGPHLPPAPGQPRGASRRQVTYVRSGRRAPPGGGGSGTPEPGCCAPRGRPRRKGPRWHIDLQPWAGSAQSLDEEAWRFLRYISTTQIACNHMNTDSLATDSSPTHKPWSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMANNGCEVHRFDPSVKSAHILESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSDSSVVRFWYSLLKELEQKDFRLFHSYKDLSKPQLFLKKDIFNASSCYTLSWVNTRWK", "length": 366 }, "evidence": [ { "id": "E1B869", "url": "https://omabrowser.org/oma/group/E1B869/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CCB5-1", "protein_name": "Probable methyltransferase-like protein 24", "gene_name": "Mettl24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATVKPPGRGCGALPRWLLGAALLLGLRLCMELRHAGSGPPGRGDSPGPPRTHLLSAPGSPRGARRRQVTYVRSGRRVLPRGGGSTTSPEPSCCAQGGLLRRKGSRWHIELQPWAGPSRSLDEEASRFLSYISTTQIACDHMGTDSLATDSSPAPKPWLVCLDDRFGLAHQIRSKRCRLYSLGLGSDDTHFEVSMANGGCEVHRFDPSVKSAHVLERQGLWHHRLSIDWRDPHPAVAAQKPHGNTRKLGSILNEFGHHKIDVLKADLESAEWKVLENLILEDVLEQIGQLVFEIHLHWPGFEVSGSESGVVRFWYSLLKELERKHFRLFHTYKDLTKPQLFLKKDLFNASSCYTLSWVNTKWR", "length": 363 }, "evidence": [ { "id": "E1B869", "url": "https://omabrowser.org/oma/group/E1B869/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B869-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 366, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B869-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B869" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B869" }, { "id": "PF13383", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13383" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methyltransferase", "eco_id": "ECO_0000259", "start_pos": 173, "end_pos": 299, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 351, "end_pos": 353 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8B1-1", "uniprot_ac": "E1B8B1", "uniprot_id": "E1B8B1_BOVIN", "mass": { "chemical_mass": 76294.0, "monoisotopic_mass": 76294.0 }, "refseq": { "ac": "NP_001178207", "name": "leucine-rich repeat-containing protein 45", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178207" }, "gene_names": [ { "name": "LRRC45", "type": "recommended", "evidence": [ { "id": "E1B8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ] }, { "name": "LRRC45", "type": "synonym", "evidence": [ { "id": "NP_001178207", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178207" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 45", "type": "synonym", "evidence": [ { "id": "E1B8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8B1/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 45", "type": "synonym", "evidence": [ { "id": "NP_001178207", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178207" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC45", "url": "https://www.uniprot.org/uniprotkb/E1B8B1", "locus": { "chromosome": "19", "start_pos": 50879836, "end_pos": 50887669, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004111", "url": "https://www.ensembl.org/id/ENSBTAG00000004111" } ] } } ], "crossref": [ { "id": "E1B8B1", "url": "https://alphafold.ebi.ac.uk/entry/E1B8B1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004111", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514524", "url": "https://www.ncbi.nlm.nih.gov/gene/514524", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514524", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514524", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVDHMTR", "url": "https://omabrowser.org/oma/group/EVDHMTR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8B1", "url": "https://www.orthodb.org/?gene=E1B8B1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23170:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23170:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178207", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P2W0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2W0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2W0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8B1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEFRRAYSRLCKESGTEPQETVLQQLHQLPQGRLDLATQSLTVDTCRALGKLLQKESLLTELILSDCMLSEEGATLLLQGLCVNTAVRFLDLKGNNLRAAGAEALAKLLRQNKSIQSLTLEWNNLGTWDEAFATFCGALAANGALRQLDLRNNQINHKGAEELALALKSNASLQQLDLRWNHIGLLGGRALVNCLPSNRTLWKLELAGNNIPGDILRAVEQAMDHNQDRQTVFRESQARAQVLSKEVRHLREEKSKQFLDLMETIDRQREEMARSSKASAARVGQLQEALNERHSIINSLKAKLQMTEAALALSEQKAQDLGELLATTEQEQRSLVQRQAKEHRLEQQEAAERESKLLRDLSAANEKNLLLRNQVDELERKVKSQQEQLFLTKTELTNTTAELKMRAIQAEERLELEKNRSRQSLEDAEHLRFKEVEHMTRHLEDSERAMQERVQRLEAARLSLEEELSRVKAAALTERSQAEEELIKAKNQVRLEEQQHQAHLEEKLRLLAQARDEAQSTCLQQKQTVADAQARASQLGMQVESLRRRLEELQQELSNKDQEKVAEVTRVRLELQEQNGRLQAELTAQEALKEKAAALERQLKVIASDHREALLDRESENASLREKLRLKEAEIARIRDEEAQRASFLQNAVLAYVQGSPLRTLSPQK", "length": 670, "header": "tr|E1B8B1-1|E1B8B1_BOVIN Isoform 1 of Leucine rich repeat containing 45 OS=Bos taurus OX=9913 GN=LRRC45 PE=4 SV=3 CANONICAL=E1B8B1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P2W0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2W0/entry", "sequence": { "sequence": "MEEFRRAYSRLCKESGTEPQETVLQQLHQLPQGRLDLATQSLTVDTCRALGKLLQKESLLTELILSDCMLSEEGATLLLQGLCVNTAVRFLDLKGNNLRAAGAEALAKLLRQNKSIQSLTLEWNNLGTWDEAFATFCGALAANGALRQLDLRNNQINHKGAEELALALKSNASLQQLDLRWNHIGLLGGRALVNCLPSNRTLWKLELAGNNIPGDILRAVEQAMDHNQDRQTVFRESQARAQVLSKEVRHLREEKSKQGISCTCGAASGSPEREAFHHQFPQGQEAAERESKLLRDLSAANEKNLLLRNQVDELERKVKSQQEQLFLTKTELTNTTAELKMRAIQAEERLELEKNRSRQSLEDAEHLRFKEVEHMTRHLEDSERAMQERVQRLEAARLSLEEELSRVKAAALTERSQAEEELIKAKNQVRLEEQQHQAHLEEKLRLLAQARDEAQSTCLQQKQTVADAQARASQLGMQVESLRRRLEELQQELSNKDQEKVAEVTRVRLELQEQNGRLQAELTAQEALKEKAAALERQLKVIASDHREALLDRESENASLREKLRLKEAEIARIRDEEAQRASFLQNAVLAYVQGSPLRTLSPQK", "length": 605, "header": "tr|A0ABI0P2W0-1|A0ABI0P2W0_BOVIN Computationally mapped isoform of Leucine rich repeat containing 45 OS=Bos taurus OX=9913 GN=LRRC45 PE=4 SV=1 CANONICAL=E1B8B1-1" }, "locus": { "chromosome": "19", "start_pos": 50887202, "end_pos": 50880273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148166.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148166.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105764.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105764.1" } ] } }, { "isoform_ac": "E1B8B1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1/entry", "sequence": { "sequence": "MEEFRRAYSRLCKESGTEPQETVLQQLHQLPQGRLDLATQSLTVDTCRALGKLLQKESLLTELILSDCMLSEEGATLLLQGLCVNTAVRFLDLKGNNLRAAGAEALAKLLRQNKSIQSLTLEWNNLGTWDEAFATFCGALAANGALRQLDLRNNQINHKGAEELALALKSNASLQQLDLRWNHIGLLGGRALVNCLPSNRTLWKLELAGNNIPGDILRAVEQAMDHNQDRQTVFRESQARAQVLSKEVRHLREEKSKQFLDLMETIDRQREEMARSSKASAARVGQLQEALNERHSIINSLKAKLQMTEAALALSEQKAQDLGELLATTEQEQRSLVQRQAKEHRLEQQEAAERESKLLRDLSAANEKNLLLRNQVDELERKVKSQQEQLFLTKTELTNTTAELKMRAIQAEERLELEKNRSRQSLEDAEHLRFKEVEHMTRHLEDSERAMQERVQRLEAARLSLEEELSRVKAAALTERSQAEEELIKAKNQVRLEEQQHQAHLEEKLRLLAQARDEAQSTCLQQKQTVADAQARASQLGMQVESLRRRLEELQQELSNKDQEKVAEVTRVRLELQEQNGRLQAELTAQEALKEKAAALERQLKVIASDHREALLDRESENASLREKLRLKEAEIARIRDEEAQRASFLQNAVLAYVQGSPLRTLSPQK", "length": 670, "header": "tr|E1B8B1-1|E1B8B1_BOVIN Isoform 1 of Leucine rich repeat containing 45 OS=Bos taurus OX=9913 GN=LRRC45 PE=4 SV=3 CANONICAL=E1B8B1-1" }, "locus": { "chromosome": "19", "start_pos": 50887202, "end_pos": 50880273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042654.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042654.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040289.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040289.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514524", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514524", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K878-1", "protein_name": "Leucine rich repeat containing 45", "gene_name": "Lrrc45", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSAMLPGSCSSYPLSGASHSSWILRREEPRSATPATRGYVARAGWGPQGRSRGHACEVLSAFGDMEEFRRSYNRLCKESGAEPQEAVLQQLHQLSRGGLDLTTQSLTVDTCRALGKLLHKETLLKELVLSDCMLSEEGSTLLLQGLCANTSVQLLDLKGNNLRATGAEALGKLLRQNKSIQSLTLEWNNLGTWEEAFATFCGGLAANGTLRQLDLRNNQISHKGAEELALALKGNATLQQLDLRWNNIGLLGGRALVNCLPSNRTLWKLDLAGNNIPGDILRAVEQAMDHNQDRITAFRENQTRTKILSKEVQHLQEEKSKQFLDLMETIDKQREEMARDSRASAVRVGQLQEALNERQSIINALKAKLQMTEAALALSEQKAQDLGELLAAAEQERQSLSQRQEKERKLEQQEAADRESKLLRDLSAANEKNLLLRSQVDELERKVKSQQEQLFLTRQELTNTSAELKIRAIQAEEHLDMEKRRAKQNMEDLEKLHCKEVDHMTRHLEESERAMQERVQRLEALRLSLEEELSRMKAAVLSERSQAEEELIKAKNQARLEEQHRLAHLEEKIRLLAQARDEAQGTCMQQKQMVAQSQARASQLNLQMEGQQRRLEELQQELSNKDQEKVAEVARVRVELQEQMGRMQADLVAQEVLREKVAALERQLKVVGSEHREALLDRESENASLREKLRLKEAEISRIRDEEAQRASFLQNAVLAYVQGSPLRALSPPK", "length": 735 }, "evidence": [ { "id": "E1B8B1", "url": "https://omabrowser.org/oma/group/E1B8B1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A286ZKH0-1", "protein_name": "Leucine rich repeat containing 45", "gene_name": "LRRC45", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEELQRAYSRLCKESGAEPQSLTLDTCRALGKLLQKEALLTELVLSDCMLSDEGATMLLQGLCVNTVVRFLDLKGNNLRAAGAEALGKLLRQNKSIQSLTLEWNSLGPWEDAFATFCGALAANSTLRQLDLRNNQISHKGAEELALALRSNASLQQLDLRWNHIGLLGGRALANCLPSNRTLWRLELAGNSIPSDVLRAVEQAMDRNQDRQATVRESQARAHILSKEVQHLREEKSKQFLDLMETIDRQRQEMAKSSTASAARVGRLQEALSERHSVISALKAKLQMAEAALALSEQKARDLGERLATAEQEQRSLAQRQAKEHRLELQEAADRESKLLRDLSAAQEKNLRLRNQVDELERKVKSQQEQLFLSRQELTTTSAELKMRAAQAEERLELEKTRSRQNLEDAEHLRFKEVEHMTRHLEESEKAMQDRVQRLEAVRLSLEEELSQVKAAALSERGRAEEELLKAKSQVRLEEQQRLAHLEEKLRLLAQARDEAQSACLQQKQMVADAQARASQLGLQVEGLRRRLEELQQELSNKDQEKAAEVTRVRLELQEQNGRLQAELTAQEALKEKAAALERQLKVIASDHREALLDRESENASLREKLRLKEAEIARIREEEAQRASFLQNAVLAYVQGSPLRTLSPPK", "length": 650 }, "evidence": [ { "id": "E1B8B1", "url": "https://omabrowser.org/oma/group/E1B8B1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GXC7-1", "protein_name": "Leucine-rich repeat-containing protein 45 isoform X1", "gene_name": "Lrrc45", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEELRRSYSLLCEESGAEPQEAVLQQLQQLPRGRLDLATQSLTLDTCRALGKLLHDEKLLKELVLSDCMLSEEGSTLLFQGLCANTTVQRLDLKGNNLRATGAEALGKLLRQSKSIQSLTLEWNNLGMWEDAFASFCGGLAANSTLRQLDLRNNQISHKGAEELALALKGNTTLRHLDLRWNNIGLLGGRALVNCLPSNRTLRRLDLAGNNIPGDILRAVEQAMDHNQDRLTAFWENQARTNILSKEVQHLQEEKSKQFLDLMETIDKQREEIARNGRASAARVGQLQEALNERQSIINALKAKLQMTEAALALSEQKAQDLGELLTTAEQERQSLSQRQEKERKLEQQEAADRESKLLRDLSAANEKNLLLRSQVEELERKVKSQQEQLFLTRQELTNTSAELKIRAIQAEERLDVEKRRAKQNMEDLEKLHSKEVDHMTRHLEESERAMQERIQRLEALRLSLEEELSRMKAALLSERGQAEEELIKARNQARLEEQHRLAHLEEKIRLLAQARDEAQGTCLQQKQMVAESQARASQLNLQMEGQQRRLEELQQELSNKDQEKVAEVTRVRVELQEQMGRMQADLVAQEVLKEKVAALERQLKVIGNEHREALLDRESENASLREKLRLKEAEISRIRDEEAQRASFLQNAVLAYVQGSPLRALSPPK", "length": 670 }, "evidence": [ { "id": "E1B8B1", "url": "https://omabrowser.org/oma/group/E1B8B1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8CIM1-1", "protein_name": "Leucine-rich repeat-containing protein 45", "gene_name": "Lrrc45", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEFRRSYNRLCEESGAEPQEAVLQQLHQLPKGGLDLTTQSLTVETCRALGKLLHKETLLKELVLSDCMLSEEGSTLLFQGLCANTSVQHLDLKGNNLRATGAEALGKLLRQNKSIQSLTLEWNNLGTWEDAFATFCGGLAANSALRQLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNIGLLGGRALVNCLPSNRTLWKLDLAGNNIPGDILRAVEQAMDHNQDRLTAFRENQARTKILSKEVQHLQEEKSKQFLDLMETIDKQREEMARDSRASAVRVGQLQEALNERQSIINALKAKLQMTEAALALSEQKVRDLGELLVAGDQERQSLSQRHEKERKLERQEAADRESKLLRDLSAASEKNLLLRSQVDELERKARSQQEQLFLTKQELTNTSAELKIRAIQAEERLDVEKRRAKQNMEDLEKLHSKEVDHMTRHLEESERAMQERVQRLEALRLSLEEELSRMKAAVLSERGQAEEELIKARNQARLEEQHRLAHLEEKIRLLAQARDEAQGTCVQQKQMVAESQARVSQLNLQMEGQQRRLEELQQELINKDQEKVAEVARVRVELQEQMGRMQADLVAQEALREKVAALERQMKVIGSEHREALLDRESENASLREKLRLKEAEISRIRDEEAQRASFLQNAVLAYVQGSPLRALSPPK", "length": 670 }, "evidence": [ { "id": "E1B8B1", "url": "https://omabrowser.org/oma/group/E1B8B1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96CN5-1", "protein_name": "Leucine-rich repeat-containing protein 45", "gene_name": "LRRC45", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRTLSPPK", "length": 670 }, "evidence": [ { "id": "E1B8B1", "url": "https://omabrowser.org/oma/group/E1B8B1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "pmid": "" }, { "name": "protein localization to centriolar satellite", "id": "GO:0120329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120329", "evidence": [ { "database": "UniProtKB", "id": "E1B8B1", "url": "https://www.uniprot.org/uniprotkb/E1B8B1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8B1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 670, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8B1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8B1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 399, "end_pos": 401 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 622, "end_pos": 624 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8B2-1", "uniprot_ac": "E1B8B2", "uniprot_id": "E1B8B2_BOVIN", "mass": { "chemical_mass": 48551.0, "monoisotopic_mass": 48551.0 }, "refseq": { "ac": "XP_002698601", "name": "ATPase PAAT", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698601" }, "gene_names": [ { "name": "LOC510536", "type": "recommended", "evidence": [ { "id": "E1B8B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8B2" } ] }, { "name": "LOC510536", "type": "synonym", "evidence": [ { "id": "XP_002698601", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698601" } ] } ], "protein_names": [ { "name": "Protein associated with ABC transporters", "type": "recommended", "evidence": [ { "id": "E1B8B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8B2/entry#names_and_taxonomy" } ] }, { "name": "ATPase PAAT", "type": "synonym", "evidence": [ { "id": "XP_002698601", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698601" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8B2", "url": "https://www.uniprot.org/uniprotkb/E1B8B2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC510536", "url": "https://www.uniprot.org/uniprotkb/E1B8B2", "locus": {} } ], "crossref": [ { "id": "E1B8B2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8B2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023845", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023845", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000023846", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023846", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510536", "url": "https://www.ncbi.nlm.nih.gov/gene/510536", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510536", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510536", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMLQNVC", "url": "https://omabrowser.org/oma/group/PMLQNVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8B2", "url": "https://www.orthodb.org/?gene=E1B8B2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MIU1", "url": "https://www.orthodb.org/?gene=F1MIU1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14787", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14787", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14787:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14787:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14958", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14958", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698601", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698601", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8B2", "url": "https://www.uniprot.org/uniprotkb/E1B8B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8B2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIU1", "url": "https://www.uniprot.org/uniprotkb/F1MIU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIU1-1", "url": "https://www.uniprot.org/uniprotkb/F1MIU1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METETVHGPLTRRPTLVSSWDAECGALAQSLRLIRAGLGARDADWEELLAPPASGQDQVTLKRNLNNQDENPCFLYLRCDPHGGEEIVSIGILSSARNMEVYLGEEYCGTSRGKNVCNVLDNSEHEKITFYKKYLKLESPTHACKIKLLSFGEKNCVFISKVVVHVRQVSAHSSAGSPTLGSRIDLERVQTIMESMGSKLSPGAQQLMNMVRFQQQNCVAIGEQLQSILGNTGHKHVMGLPSSSTPGAFDKSSCTPFPFRTGLTSGNVTDDSEATTEKSLQPAGGGSMSSLQECKIGPQSRSILENDLKNAVSSFLSKKAGDSSHIPNSELLPFLQNLCGQVSHLRVGPGTKWQDSITKPGGGAGGVTLEEQSICSYLEKILSKNLELMEKKLTDYVDQRIYKLQEHIDNKMALLMDLLQRPNSPPSGMPLRHYDSGEGLSNGER", "length": 445, "header": "tr|E1B8B2-1|E1B8B2_BOVIN Isoform 1 of Protein associated with ABC transporters OS=Bos taurus OX=9913 GN=LOC510536 PE=4 SV=3 CANONICAL=E1B8B2-1" }, "isoforms": [ { "isoform_ac": "E1B8B2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8B2/entry", "sequence": { "sequence": "METETVHGPLTRRPTLVSSWDAECGALAQSLRLIRAGLGARDADWEELLAPPASGQDQVTLKRNLNNQDENPCFLYLRCDPHGGEEIVSIGILSSARNMEVYLGEEYCGTSRGKNVCNVLDNSEHEKITFYKKYLKLESPTHACKIKLLSFGEKNCVFISKVVVHVRQVSAHSSAGSPTLGSRIDLERVQTIMESMGSKLSPGAQQLMNMVRFQQQNCVAIGEQLQSILGNTGHKHVMGLPSSSTPGAFDKSSCTPFPFRTGLTSGNVTDDSEATTEKSLQPAGGGSMSSLQECKIGPQSRSILENDLKNAVSSFLSKKAGDSSHIPNSELLPFLQNLCGQVSHLRVGPGTKWQDSITKPGGGAGGVTLEEQSICSYLEKILSKNLELMEKKLTDYVDQRIYKLQEHIDNKMALLMDLLQRPNSPPSGMPLRHYDSGEGLSNGER", "length": 445, "header": "tr|E1B8B2-1|E1B8B2_BOVIN Isoform 1 of Protein associated with ABC transporters OS=Bos taurus OX=9913 GN=LOC510536 PE=4 SV=3 CANONICAL=E1B8B2-1" }, "locus": { "chromosome": "26", "start_pos": 42723875, "end_pos": 42705710, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032748.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032748.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032677.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032677.4" } ] } }, { "isoform_ac": "F1MIU1-1", "url": "https://www.uniprot.org/uniprotkb/F1MIU1/entry", "sequence": { "sequence": "METETVHGPLTRRPTLVSSWDAECGALAQSLRLIRAGLGARDADWEELLAPPASGQDQVTLKRNLNNQDENPCFLYLRCDPHGGEEIVSIGILSSARNMEVYLGEEYCGTSRGKNVCNVLDNSEHEKITFYKKYLKLESPTHACKIKLLSFGEKNCVFISKVVVHVRQVSAHSSAGSPTLGSRIDLERVQTIMESMGSKLSPGAQQLMNMVRFQQQIWAIVPSSTPSPVTSPQMLVSGHSENCVAIGEQLQSILGNTGHKHVMGLPSSSTPGAFDKSSCTPFPFRTGLTSGNVTDDSEATTEKSLQPAGGGSMSSLQECKIGPQSRSILENDLKNAVSSFLSKKAGDSSHIPNSELLPFLQNLCGQVSHLRVGPGTKWQDSITKPGGGAGGVTLEEQSICSYLEKILSKNLELMEKKLTDYVDQRIYKLQEHIDNKMALLMDLLQRPNSPPSGMPLRHYDSGEGLSNGER", "length": 470, "header": "tr|F1MIU1-1|E1B8B2_BOVIN Computationally mapped isoform of Protein associated with ABC transporters OS=Bos taurus OX=9913 GN=LOC510536 PE=4 SV=3 CANONICAL=E1B8B2-1" }, "locus": { "chromosome": "26", "start_pos": 42723875, "end_pos": 42705710, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032750.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032750.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032679.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032679.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 245, "start_aa": "Thr", "end_pos": 245, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr245", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510536", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510536", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X9X0-1", "protein_name": "Chromosome 10 open reading frame 88", "gene_name": "C10orf88", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASGGALGPAPDPPGVAVGCSWPCVPPDGLARALCLRRGAGRDEASGEAVAVERRAGGGDAPCVLQLECRPGAERVAAVGVVSEARHMEVYVGEEYCGTGRGVSAGVLQPPGQTETVTLYEKYLKLECPATSCRIKLLSIGEKQRVLISKIIVQVNTVSAKLATDFPSLGSSIDLDRVQTIMESMGSKLSPGAQQLMDMVRYQQKNSLPLGDRLSWMLGKNSDFGNEHPVDGLHGAGIQTSLHQSVSESPSVRNPLTSETGCENLNLDLEAQVPDREDASNSIELNTQQNTVDLRNDFKAMGSLLMQEQTDRIRNIAAPQMLLPFLQNLCSQVNHLRLKDGERHLDKNVVTKEEGIQTVGIEQQPICSYLEKIISKNMDLMEKKLTDYIDRQIQALQAHIDDKMVLLADLVQNSKQNKISQAHYDSNEGFSNGER", "length": 435 }, "evidence": [ { "id": "E1B8B2", "url": "https://omabrowser.org/oma/group/E1B8B2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FS40-1", "protein_name": "ATPase PAAT isoform X1", "gene_name": "C3H10orf88", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METAIEDPGLDHGPTLTSSWVAACGSLTQSLLTRIGPGAQDLNFEQLLAPPALGCAGPGPGDNHAAEKPGGAREASERGQPGSDLVSLKNNLSPRDENPCFLYLKCGPNGGEEILSVGILSSARNMEVYLGEEYCGTSRGKNVCTALDDSEHEKILLYKKFLKLESPTHACKIKLLSFGEKQCVLISKVVVHVRPRSANPSPSSSALGSRIDLDSIQTIMESMGSKLSPGAQQLMNMIRFQQQNRLPIGDQLQSVLGTTGHKHLIALQSSPSSGVVDKASSTPFPFRTGLTPSAITENLKALIDKGTQPPGEGNTTNHDECHLVPQNHSLLENDLKNAVSSFLPKKASGNSNVPNSELLPFLQNLCSQVNHLRVGHNARWQENISKPRESIVGVSMEEQPICSYLEKILSKNMELMEKKLMDHIDERIYQLQEHIDAKMALLVDLLQNPNSPPPGIPLRHYDSRERLSNGER", "length": 472 }, "evidence": [ { "id": "E1B8B2", "url": "https://omabrowser.org/oma/group/E1B8B2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LBP2-1", "protein_name": "Protein associated with ABC transporters", "gene_name": "LOC100154423", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METGAVDAPLTRRPTLAASWDAACGALAQSLRLARAGLGARDADWEQLLAPPATGQDLVILKRSLHRQGENPCFLHVRCDPRGGEEMVSVGVLSSARNMEVYLGEEYCGTSRGKSVCNVLDNSEQEKITLYKTYLKLESSTRACKIKLLSFGEKQCVFISRVVVHVRPVSPASPASCPPLGPRIDLERVQTILESMGSKLSPGAQQLMSLVRFQQQQMCIPIGEPPQSPRGSAGSTPGVGARASSSSGASAKSTSTPFPFRTGLTSGNRTEDVQAHPAQRTQPAAGGPVTRLQECPMGPQNQSLLENELKAAVSSFSPKRAGDSAPVANSELPPFLQNLCRQVSHLRLGPLSKWQESITRPGEGPAGLPMDEQSICSSLEKMLSKNMELMEKKLTDYIDQRIYKLQEHLDNKIALLVDLLQNPNSPPSGMPLRHYDSGERLSNGER", "length": 446 }, "evidence": [ { "id": "E1B8B2", "url": "https://omabrowser.org/oma/group/E1B8B2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D2Q3-1", "protein_name": "ATPase PAAT", "gene_name": "Paat", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METAIEDAGLDRGPTLTSSWDAACGALTQSLFLTRTGPRAQDLDFEQLLEPPAPSQDPVSLKSSLSPRDENPCFIYLNCGPNGGEEILSVGVLSSARNMEVYLGEEYCGTSRGKTACTVLDDSEHEKILLYKKYLKLDSPTHACKIKLLSFGEKQCVLVSKVVVHLRPRSADPSPRSAALGSRIDLDNIQTIMESMGSRLSPGAQQLMSMIRFQQQNRLPIGDQLQSVLGSAGHKHLMALQSSPSPAVLDKASSTPFPFRTGLTPSAITENLKALIDKSAQPSGEGNTTNHDEGHLMPQNHSLESDLKNAVSSFLPKKASGSSSVPSSELLPFLQNLCSQVNHLRVGHNARWQENISKPREGMVGVPMEEQPVCSYLEKILSKNMELMEKKLMDHIDERIYQLQEHIDAKMALLVDLLRGPNSPPPGMPLRHYDSRERLSNGER", "length": 444 }, "evidence": [ { "id": "E1B8B2", "url": "https://omabrowser.org/oma/group/E1B8B2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H8K7-1", "protein_name": "ATPase PAAT", "gene_name": "PAAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METRTEDGGLTRRPTLASSWDVAGGALTHSLLLTRAGLGPGDFDWEELLAPPAPGQDLVILKRNHNNKDENPCFLYLRCGPDGGEEIASIGILSSARNMEVYLGEEYCGTSRGKNVCTVLDDSEHEKIILYKKNLKLESSTHACKIKLLSFGERQCVFISKVVVHMRSVFANSSTSSPALGSRIDLDKVQTIMESMGSKLSPGAQQLMDMVRCQQRNCIPIGEQLQSVLGNSGYKHMIGLQSSSTLGTLNKSSSTPFPFRTGLTSGNVTENLQTYIDKSTQLPGGENSTKLDECKVMPQNHSFLENDLKNAMASFLPKKVSDNSNIPNSELLPFLQNLCSQVNHLHVGNKTECQENITKHGERILGVGMEEQSICSYLEKILSKNMELMEKKLMDYIDQRIHELQEHIDDKIALLLDLLQNPNSPPTGIPLRHYDSGERLSNGER", "length": 445 }, "evidence": [ { "id": "E1B8B2", "url": "https://omabrowser.org/oma/group/E1B8B2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1B8B2", "url": "https://www.uniprot.org/uniprotkb/E1B8B2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1B8B2", "url": "https://www.uniprot.org/uniprotkb/E1B8B2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8B2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 445, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8B2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8B2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 245 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 267, "end_pos": 269 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8H4-1", "uniprot_ac": "E1B8H4", "uniprot_id": "E1B8H4_BOVIN", "mass": { "chemical_mass": 115513.0, "monoisotopic_mass": 115513.0 }, "refseq": { "ac": "XP_002687116", "name": "DENN domain-containing protein 2A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687116" }, "gene_names": [ { "name": "DENND2A", "type": "recommended", "evidence": [ { "id": "E1B8H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" } ] }, { "name": "DENND2A", "type": "synonym", "evidence": [ { "id": "XP_002687116", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687116" } ] } ], "protein_names": [ { "name": "DENN domain containing 2A", "type": "synonym", "evidence": [ { "id": "E1B8H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H4/entry#names_and_taxonomy" } ] }, { "name": "DENN domain-containing protein 2A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687116", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687116" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8H4", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENND2A", "url": "https://www.uniprot.org/uniprotkb/E1B8H4", "locus": { "chromosome": "4", "start_pos": 103877423, "end_pos": 103947944, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004799", "url": "https://www.ensembl.org/id/ENSBTAG00000004799" } ] } } ], "crossref": [ { "id": "E1B8H4", "url": "https://alphafold.ebi.ac.uk/entry/E1B8H4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004799", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512632", "url": "https://www.ncbi.nlm.nih.gov/gene/512632", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512632", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512632", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPAYVPL", "url": "https://omabrowser.org/oma/group/CPAYVPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8H4", "url": "https://www.orthodb.org/?gene=E1B8H4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15288:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15288:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687116", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687116", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8H4", "url": "https://www.uniprot.org/uniprotkb/E1B8H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8H4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8H4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEPRVDCFQQNMFSSDMIINDSASDLSAKGTSRAGKRQLGSVQDPCPPAQGKARHKSLSIKDKISEWEGKRELPTPAPGRKADGQEGYLMSCVTERRSSDGSRARVTEAQNGTRLDVESREDERDKVKVRAQDAEQRPDLSQPAREPAPSLGRGREPRLGKQRFQNDSLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCLPDKAEEAPTLPEHRGGGGGSEFRAHRLDLETREPTLEAAEERKGLCRRPCDQSLESVYRGLEDPPTKPFINPLPKPRRTFKHDGEGDKDGNLGTRFRKDRRNLPPLPSLPPPPLPSSPPPPSVNRRLWSGRPKASADHRKSYEFEDLLQSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVELHGRCLGKKCVLNFPGSPTSSIPDTPAKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDTFFNLGDLQNGRKKRKIPKLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLDRELVEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWTPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTIVVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLLCVFASLLLERRIIFIADKLSTLSTCCHAMVAAIYPFTWQHTYIPVLPPAMIDIVCSPTPFLIGLLTSSLPLLRELPLEEVLVVDLVNNRFLRQMDDEDSILPRKLQVALEHILEQRNDLASEQDDGPPDGKRGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTAGEREERTLQLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK", "length": 1022, "header": "tr|E1B8H4-1|E1B8H4_BOVIN Isoform 1 of DENN domain containing 2A OS=Bos taurus OX=9913 GN=DENND2A PE=4 SV=2 CANONICAL=E1B8H4-1" }, "isoforms": [ { "isoform_ac": "E1B8H4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8H4/entry", "sequence": { "sequence": "MLEPRVDCFQQNMFSSDMIINDSASDLSAKGTSRAGKRQLGSVQDPCPPAQGKARHKSLSIKDKISEWEGKRELPTPAPGRKADGQEGYLMSCVTERRSSDGSRARVTEAQNGTRLDVESREDERDKVKVRAQDAEQRPDLSQPAREPAPSLGRGREPRLGKQRFQNDSLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCLPDKAEEAPTLPEHRGGGGGSEFRAHRLDLETREPTLEAAEERKGLCRRPCDQSLESVYRGLEDPPTKPFINPLPKPRRTFKHDGEGDKDGNLGTRFRKDRRNLPPLPSLPPPPLPSSPPPPSVNRRLWSGRPKASADHRKSYEFEDLLQSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVELHGRCLGKKCVLNFPGSPTSSIPDTPAKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDTFFNLGDLQNGRKKRKIPKLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLDRELVEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWTPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTIVVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLLCVFASLLLERRIIFIADKLSTLSTCCHAMVAAIYPFTWQHTYIPVLPPAMIDIVCSPTPFLIGLLTSSLPLLRELPLEEVLVVDLVNNRFLRQMDDEDSILPRKLQVALEHILEQRNDLASEQDDGPPDGKRGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTAGEREERTLQLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK", "length": 1022, "header": "tr|E1B8H4-1|E1B8H4_BOVIN Isoform 1 of DENN domain containing 2A OS=Bos taurus OX=9913 GN=DENND2A PE=4 SV=2 CANONICAL=E1B8H4-1" }, "locus": { "chromosome": "4", "start_pos": 103944278, "end_pos": 103878427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033630.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033630.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033540.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033540.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 468, "start_aa": "Thr", "end_pos": 468, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr468", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512632", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512632", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LYI0-1", "protein_name": "DENN domain containing 2A", "gene_name": "Dennd2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGREEGAHVTADGRGAAQGRGRGRARQRPEGTQRASQAGGSGDRTRARAAGTRGAPGGRGRPRGQRRGGQRAMAPQVPAAPAPGNRELRPRTRGAASRGEAALGTLPRSPGDRRGERSIVLPRIGLTLGPKKLAESGQSRALRCAGAPGRLVKAEVAKPREASRRQLLGRSVSLQKTNPAPPLGRSPSSPHTLMLEARVDMLSSNMIISGPAADLGAKEASRPLKKQLSSVQNPGPSTQARAQPLSIKDKISKWEGKKEPPASDPARQTDGQEDYLPSCRVERRGSELTRTKNGMRLETESLQNDSRTRTMCQDAERLPGLRQIDGQPEPSQPRGRELKPSDLRFQSDHLSVLRQVKRLEKALKDGSAGLDPQLPGTCYSPHCLPDKTEEDQPIPESHESGVSLASGRRAHHSEVREPGPEISEEWKGQENVYRGSRWHPQKPFINPVPKPRRTFKHAGEGDKDGNPGISFKKEKRNLPPLPSLPPPPPPLPSSPPPTSVNRRLWTGRQRPSADHRKSYEFEDLLQSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVESHGRCLGKKCVLTFPGSPTSSIPDTSTKQSLSKSAFFRQNSERRNFKLLDTRKLSRDGTGSPLRTSPPSTPSSPDDTFFNLGDLQNGRKKKKIPKLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYSSLDRDLIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLEKSFKFLREAEDQLKAIPQFCFPDAKDWSPVQEFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTITVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVSVFASLLLERRVIFIADKLSTLSKCCHAMVALIYPFSWQHTYIPVLPPAMIDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLINDRFLRQMEDEDSILPRKLQVALEHILEQRNDLACDQDGGPLDCVHGPESSSLSEVVSEAFVRFFVEIVGHYSLFLTSGEERSLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK", "length": 1191 }, "evidence": [ { "id": "E1B8H4", "url": "https://omabrowser.org/oma/group/E1B8H4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SRP8-1", "protein_name": "DENN domain containing 2A", "gene_name": "DENND2A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MISSNMIISDPGSDLSAKGTSRAGKRQHSGVQNPCPPARGGARHKSLSIKDKISEWEGKRESPAPAPGRKTDGQEDYLPSCVMERRGSEGARTRAREAQNGTRLGPESKEDARNKGAAEVRAWDAEGRQDPSQPARELAPRAARGREPSLSKQRFQNDSLSVLNQVKKLEQALKDGSAGLDPQLPGTCYSPHCLPDKAEEGHPLPEPRGSGSVSEVRAHPLDLEAREAAPEAAEQRKGSCGRPCDPSLESGYREDSPSKPFINPLPKPRRTFKHDGEGDKDGNPGISFRKDKRNLPPLPSLPPPPLPSSPPPSSVNRRLWNGRPKPSADHRKSYEFEDLLQSSCENSMVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVELHGRCLGKKCVLNFPSSPTSSIPDTPAKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPSRVSPPSTPSSPDDTFFNLGDPQNGRKKRKIPKLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLDRELVEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWTPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTIVVKNFLPGSGTEVIELCRPLDSRLEHVDLESLFSSLSVRHLLCVFASLLLERRVIFIADKLSTLSKCCHAMVAVIYPFTWQHTYIPVLPPAMVDIVCSPTPFLIGLLTSSLPLLRELPLEEVLVVDLANNRFLRQMDDEDSILPRKLQVALEHILEQRNDLASEQDAGPPDCKRGPEPSPLNEVVSEAFVRFFVEIVGHYSLFLTAGDREERSLQREAFRKAVSSKSVRRFLEVFMETQMFRGFIQERELRRQDPKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK", "length": 1008 }, "evidence": [ { "id": "E1B8H4", "url": "https://omabrowser.org/oma/group/E1B8H4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HGJ8-1", "protein_name": "DENN domain-containing protein 2A isoform X1", "gene_name": "Dennd2a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLEARVDMLASNMLISGPAADLGAKEASRPSKKQLGSVQNTGLSARVRAQPQPLSIKDKISKWEGKKEPPAPEPARQTDGQENYLPPCGVETRGGEVTRTKNGMRLETESLGNDSRKTARSVCQDTGRWPVPQQSNGQPESSQHRGLELKPSDLRFQSDHLSVLKQVKRLEKALKDGSAGLDPQLPGTCYSPHCLPDKTEEDQPTPESHGNGGALAAGRRAHHLEGNEPGPEVSEDWKGQESVYRGSRRCPPKPFINPLPKPRRTFKHAGEGDKDASLGMNFRKEKRTLPPLPSLPPPSPPPPPPLPSSPPPTSVNRRLWTGRQRPSADHRKSYEFEDLLQSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLTFPGSPASSIPDTSTKQSLAKSAFFRQNSERRNFKLLDTRKLSRDGTGSPVRASPPSTPSSPDDTFFNLGDLQNGRKKKKIPRLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDDNSESDSDTEEKLKAHSRRLVNVKSRLKQAPRYSSLDRDLIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLEKSFKFMREAEDQLKAIPQFCFPDAKDWAPVQEFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTIIVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVSVFASLLLERRVIFIADKLSTLSKCCHAMVALIYPFSWQHTYIPVLPPAMIDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLINDRFLRQMEDEDSILPRKLQVALEHILEQRNDLACDQDGGPLDCVHGPESSPLNEVVSEAFVRFFVEIVGHYPLFLTSGEERSLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYLGTLPIGEHSGVNKFLKGLGNKMKFLHKK", "length": 1006 }, "evidence": [ { "id": "E1B8H4", "url": "https://omabrowser.org/oma/group/E1B8H4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8C4S8-1", "protein_name": "DENN domain-containing protein 2A", "gene_name": "Dennd2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLEARVDMLSSNMIISGPAADLGAKEASRPWKKQLNSVPNSGPSARARAQPQPLSIKDKISKWEGKKEPPASDPARQTDGQEDHLPSCKVERRGSELTRTKNGMRLETERLQNDSRARTVCQDTEQLPGPRPIDGQPELSQHRGRELKPSDLRFQSDHLSVLRQVKRLEKALKDGSAGLDPQMPGTCYSPHCLPDKTEEDLPSLESHEKGGVLAAGRRAHHLEVREPGPEISEDWKGQESVYRGSRWYPPKPFINPVPKPRRTFKHAGEGDKDVSPGISFKKEKRNLPPLPSLPPPPPPLPSSPPPTSVNRRLWTGRQRPSADHRKSYEFEDLLQSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVELHGRCLGKKCVLTFPASPTSSIPDTSTKQSLSKSAFFRQNSERRNLKLLDTRKLSRDGAGSPLRTSPPSTPSSPDDTFFNLGDLQNGRKKKKIPRLVLRINAIYEARRGKKRVKRLSQSTESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYSSLDRDLIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLEKSFKFMREAEDQLKAIPQFCFPDAKDWAPVQEFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTIIVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVSVFASLLLERRVIFIADKLSTLSKCCHAMVALIYPFSWQHTYIPVLPPAMIDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLINDRFLRQMEDEDSILPRKLQVALEHILEQRNDLACDQDGGPLDCVHGPESSSLSEVVSEAFVRFFVEIVGHYPLFLTSGEERSLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK", "length": 1000 }, "evidence": [ { "id": "E1B8H4", "url": "https://omabrowser.org/oma/group/E1B8H4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ULE3-1", "protein_name": "DENN domain-containing protein 2A", "gene_name": "DENND2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSLNIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTESTEKERNKGAVNVGGQDPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVHPSDLEGREPTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLPSLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKSYEFEDLLQSSSESSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLNFPASPTSSIPDTLTKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDIFFNLGDPQNGRKKRKIPKLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK", "length": 1009 }, "evidence": [ { "id": "E1B8H4", "url": "https://omabrowser.org/oma/group/E1B8H4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B8H4", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "E1B8H4", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1B8H4", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "E1B8H4", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8H4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1022, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8H4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8H4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H4" }, { "id": "PS50211", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UDENN", "eco_id": "ECO_0000259", "start_pos": 577, "end_pos": 982, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 468 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 21, "end_pos": 23 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8H8-1", "uniprot_ac": "E1B8H8", "uniprot_id": "E1B8H8_BOVIN", "mass": { "chemical_mass": 45956.0, "monoisotopic_mass": 45956.0 }, "refseq": { "ac": "NP_001192811", "name": "SEC14-like protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192811" }, "gene_names": [ { "name": "SEC14L3", "type": "recommended", "evidence": [ { "id": "E1B8H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H8" } ] }, { "name": "SEC14L3", "type": "synonym", "evidence": [ { "id": "NP_001192811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192811" } ] } ], "protein_names": [ { "name": "SEC14 like lipid binding 3", "type": "synonym", "evidence": [ { "id": "E1B8H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H8/entry#names_and_taxonomy" } ] }, { "name": "SEC14-like 3", "type": "synonym", "evidence": [ { "id": "NP_001192811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192811" } ] }, { "name": "SEC14-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001192811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192811" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8H8", "url": "https://www.uniprot.org/uniprotkb/E1B8H8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC14L3", "url": "https://www.uniprot.org/uniprotkb/E1B8H8", "locus": { "chromosome": "17", "start_pos": 69431412, "end_pos": 69441202, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014464", "url": "https://www.ensembl.org/id/ENSBTAG00000014464" } ] } } ], "crossref": [ { "id": "E1B8H8", "url": "https://alphafold.ebi.ac.uk/entry/E1B8H8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014464", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014464", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521133", "url": "https://www.ncbi.nlm.nih.gov/gene/521133", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521133", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521133", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WAFSTVW", "url": "https://omabrowser.org/oma/group/WAFSTVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8H8", "url": "https://www.orthodb.org/?gene=E1B8H8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23324", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23324", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23324:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23324:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00650", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00650", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192811", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8H8", "url": "https://www.uniprot.org/uniprotkb/E1B8H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8H8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8H8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRVGDLSPKQAESLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEAMLRKYMEFRKTMDIDHILEWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDLLKTKMRDCERILHECDLQTERLGRKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIVVLGSNWKEGLLKLISPEQLPAQFGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEHSAQISRGSSHQVEYEILFPGCVLRWQFASDGGDIGFGVFLKTKMGERQRAAEMTEVLASQRYNAHMVPEDGSLTCTEAGVYVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDKELTPV", "length": 400, "header": "tr|E1B8H8-1|E1B8H8_BOVIN Isoform 1 of SEC14 like lipid binding 3 OS=Bos taurus OX=9913 GN=SEC14L3 PE=4 SV=1 CANONICAL=E1B8H8-1" }, "isoforms": [ { "isoform_ac": "E1B8H8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8H8/entry", "sequence": { "sequence": "MSGRVGDLSPKQAESLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEAMLRKYMEFRKTMDIDHILEWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDLLKTKMRDCERILHECDLQTERLGRKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIVVLGSNWKEGLLKLISPEQLPAQFGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEHSAQISRGSSHQVEYEILFPGCVLRWQFASDGGDIGFGVFLKTKMGERQRAAEMTEVLASQRYNAHMVPEDGSLTCTEAGVYVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDKELTPV", "length": 400, "header": "tr|E1B8H8-1|E1B8H8_BOVIN Isoform 1 of SEC14 like lipid binding 3 OS=Bos taurus OX=9913 GN=SEC14L3 PE=4 SV=1 CANONICAL=E1B8H8-1" }, "locus": { "chromosome": "17", "start_pos": 69441150, "end_pos": 69432161, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019231.4", "url": "https://www.ensembl.org/id/ENSBTAT00000019231.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019231.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019231.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521133", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521133", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P24280-1", "protein_name": "SEC14 cytosolic factor", "gene_name": "SEC14", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVTQQEKEFLESYPQNCPPDALPGTPGNLDSAQEKALAELRKLLEDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAYSVMSYVREASYISQNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLPVKFGGKSEVDESKGGLYLSDIGPWRDPKYIGPEGEAPEAFSMK", "length": 304 }, "evidence": [ { "id": "E1B8H8", "url": "https://omabrowser.org/oma/group/E1B8H8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5SQ27-1", "protein_name": "SEC14-like lipid binding 3", "gene_name": "Sec14l3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEAMLRKYMEFRKTMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDLLKTKMRDCERILHECDLQTERLGRKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIVVLGSNSWKEGLLKLISPEELPAHFGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEHSVQISRGSSHQVEYEILFPGCVLRWQFSSDGADIGFGVFLKTKMGERQKAGEMVEVLTSQRYNAHMVPEDGSLTCSEAGVYVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDEELTPV", "length": 401 }, "evidence": [ { "id": "E1B8H8", "url": "https://omabrowser.org/oma/group/E1B8H8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UDX4-1", "protein_name": "SEC14-like protein 3", "gene_name": "SEC14L3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEALLRKYMEFRKTMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDLLKTKMRDCERILHECDLQTERLGKKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEENYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPEELPAQFGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEHSVQINRGSSHQVEYEILFPGCVLRWQFSSDGADIGFGVFLKTKMGERQRAGEMTDVLPSQRYNAHMVPEDGNLTCSEAGVYVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDKELTPV", "length": 400 }, "evidence": [ { "id": "E1B8H8", "url": "https://omabrowser.org/oma/group/E1B8H8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B8H8", "url": "https://www.uniprot.org/uniprotkb/E1B8H8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "E1B8H8", "url": "https://www.uniprot.org/uniprotkb/E1B8H8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8H8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8H8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8H8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H8" }, { "id": "PS50191", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRAL-TRIO", "eco_id": "ECO_0000259", "start_pos": 76, "end_pos": 249, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8H8" }, { "id": "PS50866", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GOLD", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 383, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8I0-1", "uniprot_ac": "E1B8I0", "uniprot_id": "E1B8I0_BOVIN", "mass": { "chemical_mass": 12858.0, "monoisotopic_mass": 12858.0 }, "refseq": { "ac": "XP_059745767", "name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745767" }, "gene_names": [ { "name": "LOC101908792", "type": "recommended", "evidence": [ { "id": "E1B8I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I0" } ] }, { "name": "LOC101908792", "type": "synonym", "evidence": [ { "id": "XP_059745767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745767" } ] } ], "protein_names": [ { "name": "RRM domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1B8I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I0/entry#names_and_taxonomy" } ] }, { "name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial-like", "type": "synonym", "evidence": [ { "id": "XP_059745767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745767" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8I0", "url": "https://www.uniprot.org/uniprotkb/E1B8I0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101908792", "url": "https://www.uniprot.org/uniprotkb/E1B8I0", "locus": {} } ], "crossref": [ { "id": "E1B8I0", "url": "https://alphafold.ebi.ac.uk/entry/E1B8I0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014133", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014133", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101908792", "url": "https://www.ncbi.nlm.nih.gov/gene/101908792", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LQENHVT", "url": "https://omabrowser.org/oma/group/LQENHVT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "XP_059745767", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745767", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8I0", "url": "https://www.uniprot.org/uniprotkb/E1B8I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8I0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSWAVRGAMELPTNIEHQLVHCICQINSLDHLSELRGHFVQVGHVGNCTVPFDNEIGFHRGMDWIQFSSEEELHTTLLQENHVTDGVKLHVQAQKPKDLQRDQTSDEEKDF", "length": 112, "header": "tr|E1B8I0-1|E1B8I0_BOVIN Isoform 1 of RRM domain-containing protein OS=Bos taurus OX=9913 GN=LOC101908792 PE=4 SV=3 CANONICAL=E1B8I0-1" }, "isoforms": [ { "isoform_ac": "E1B8I0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I0/entry", "sequence": { "sequence": "MVSWAVRGAMELPTNIEHQLVHCICQINSLDHLSELRGHFVQVGHVGNCTVPFDNEIGFHRGMDWIQFSSEEELHTTLLQENHVTDGVKLHVQAQKPKDLQRDQTSDEEKDF", "length": 112, "header": "tr|E1B8I0-1|E1B8I0_BOVIN Isoform 1 of RRM domain-containing protein OS=Bos taurus OX=9913 GN=LOC101908792 PE=4 SV=3 CANONICAL=E1B8I0-1" }, "locus": { "chromosome": "1", "start_pos": 66771900, "end_pos": 66771565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018785.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018785.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018785.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018785.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "E1B8I0", "url": "https://www.uniprot.org/uniprotkb/E1B8I0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8I0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 112, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8I0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8I0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8I3-1", "uniprot_ac": "E1B8I3", "uniprot_id": "E1B8I3_BOVIN", "mass": { "chemical_mass": 13575.0, "monoisotopic_mass": 13575.0 }, "refseq": { "ac": "XP_002692612", "name": "ly6/PLAUR domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692612" }, "gene_names": [ { "name": "LYPD2", "type": "recommended", "evidence": [ { "id": "E1B8I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I3" } ] }, { "name": "LYPD2", "type": "synonym", "evidence": [ { "id": "XP_002692612", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692612" } ] } ], "protein_names": [ { "name": "LY6/PLAUR domain containing 2", "type": "synonym", "evidence": [ { "id": "E1B8I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I3/entry#names_and_taxonomy" } ] }, { "name": "ly6/PLAUR domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_002692612", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692612" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8I3", "url": "https://www.uniprot.org/uniprotkb/E1B8I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYPD2", "url": "https://www.uniprot.org/uniprotkb/E1B8I3", "locus": { "chromosome": "14", "start_pos": 1687072, "end_pos": 1684388, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016210", "url": "https://www.ensembl.org/id/ENSBTAG00000016210" } ] } } ], "crossref": [ { "id": "E1B8I3", "url": "https://alphafold.ebi.ac.uk/entry/E1B8I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016210", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016210", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "790087", "url": "https://www.ncbi.nlm.nih.gov/gene/790087", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:790087", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790087", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCYVCPE", "url": "https://omabrowser.org/oma/group/RCYVCPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8I3", "url": "https://www.orthodb.org/?gene=E1B8I3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16983:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16983:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002692612", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692612", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8I3", "url": "https://www.uniprot.org/uniprotkb/E1B8I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8I3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWGTRLALPALVLAACCELVVTLQCYTCPEPINVSYCVTITTCNVNETMCKTTLYSLETVYPFLGDSTVTKSCASKCEPSDVDGIGWTRPVSCCNTDLCNVDGAPTLGGPCSLAGAFLLLTPLLSLHL", "length": 128, "header": "tr|E1B8I3-1|E1B8I3_BOVIN Isoform 1 of LY6/PLAUR domain containing 2 OS=Bos taurus OX=9913 GN=LYPD2 PE=4 SV=1 CANONICAL=E1B8I3-1" }, "isoforms": [ { "isoform_ac": "E1B8I3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I3/entry", "sequence": { "sequence": "MWGTRLALPALVLAACCELVVTLQCYTCPEPINVSYCVTITTCNVNETMCKTTLYSLETVYPFLGDSTVTKSCASKCEPSDVDGIGWTRPVSCCNTDLCNVDGAPTLGGPCSLAGAFLLLTPLLSLHL", "length": 128, "header": "tr|E1B8I3-1|E1B8I3_BOVIN Isoform 1 of LY6/PLAUR domain containing 2 OS=Bos taurus OX=9913 GN=LYPD2 PE=4 SV=1 CANONICAL=E1B8I3-1" }, "locus": { "chromosome": "14", "start_pos": 1686416, "end_pos": 1684534, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021572.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021572.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021572.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021572.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:790087", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790087", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BAC4-1", "protein_name": "LY6/PLAUR domain containing 2", "gene_name": "LYPD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWGTRLALLALVLAARWELVVALQCYTCHEPTSVSSCVTTATCSSNETMCKTTLYSLEIVYPFLGDSTVTKSCASKCVPSDVDGIGLTRPVSCCNTDLCNVDGASALGSPRGLATTLLLSLLIILQL", "length": 127 }, "evidence": [ { "id": "E1B8I3", "url": "https://omabrowser.org/oma/group/E1B8I3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XZJ9-1", "protein_name": "LY6/PLAUR domain containing 2", "gene_name": "LYPD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MENTNVLQTTIKKKKKKKKKHQQAAKQRYGNDLIPLGLHIMLKHKGSSLNNLSYCPSAQSLKCYTCHEPTASEKCMKIQKCAKNETMCKTTMYSLEEVYPFVGLSTVTKMCSSVCSPSDVDGIGMTRPVSCCYSNLCNIDGAASLRISFVPVGMLASVVCGLFWSRL", "length": 167 }, "evidence": [ { "id": "E1B8I3", "url": "https://omabrowser.org/oma/group/E1B8I3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A707-1", "protein_name": "Ly6/Plaur domain containing 2", "gene_name": "Lypd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQGTRMVLLALILSTFGELAMALRCYACPDPVSASDCVKITPCHTNETMCKTTLYSREIVFPFLGDSTVTKSCASKCEPSDVDGIGLTRPVSCCNSDLCNVDGAPSLGGPGGLVLVLPLIFLLHVLL", "length": 127 }, "evidence": [ { "id": "E1B8I3", "url": "https://omabrowser.org/oma/group/E1B8I3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I918-1", "protein_name": "Ly6/PLAUR domain-containing protein 2", "gene_name": "Lypd2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQGTWMVLLALVLATCGELAMALQCYTCQDPVSVSNCVAITTCHINDTMCKTTLYSREIVFPFLGDSTVTKSCASKCEPSDVDGIGLTRPVSCCNSDLCNMDGAPNLGSPGGLVLAPALIFILEHLL", "length": 127 }, "evidence": [ { "id": "E1B8I3", "url": "https://omabrowser.org/oma/group/E1B8I3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6UXB3-1", "protein_name": "Ly6/PLAUR domain-containing protein 2", "gene_name": "LYPD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRGTRLALLALVLAACGELAPALRCYVCPEPTGVSDCVTIATCTTNETMCKTTLYSREIVYPFQGDSTVTKSCASKCKPSDVDGIGQTLPVSCCNTELCNVDGAPALNSLHCGALTLLPLLSLRL", "length": 125 }, "evidence": [ { "id": "E1B8I3", "url": "https://omabrowser.org/oma/group/E1B8I3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DD23-1", "protein_name": "Ly6/PLAUR domain-containing protein 2", "gene_name": "Lypd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQGTWMVLLALILGTFGELAMALQCYTCANPVSASNCVTTTHCHINETMCKTTLYSLEIVFPFLGDSTVTKSCASKCEPSDVDGIGQTRPVSCCNSDLCNVDGAPSLGSPGGLLLALALFLLLGVLL", "length": 127 }, "evidence": [ { "id": "E1B8I3", "url": "https://omabrowser.org/oma/group/E1B8I3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8I3", "url": "https://www.uniprot.org/uniprotkb/E1B8I3" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "E1B8I3", "url": "https://www.uniprot.org/uniprotkb/E1B8I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8I3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 128, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8I3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8I3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I3" }, { "id": "SM00134", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00134" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UPAR/Ly6", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 114, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 }, { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8J9-1", "uniprot_ac": "E1B8J9", "uniprot_id": "E1B8J9_BOVIN", "mass": { "chemical_mass": 41963.0, "monoisotopic_mass": 41963.0 }, "refseq": { "ac": "NP_001193764", "name": "immediate early response gene 5-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193764" }, "gene_names": [ { "name": "IER5L", "type": "recommended", "evidence": [ { "id": "E1B8J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J9" } ] }, { "name": "IER5L", "type": "synonym", "evidence": [ { "id": "NP_001193764", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193764" } ] } ], "protein_names": [ { "name": "Immediate early response 5 like", "type": "synonym", "evidence": [ { "id": "E1B8J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J9/entry#names_and_taxonomy" } ] }, { "name": "immediate early response gene 5-like protein", "type": "synonym", "evidence": [ { "id": "NP_001193764", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193764" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8J9", "url": "https://www.uniprot.org/uniprotkb/E1B8J9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IER5L", "url": "https://www.uniprot.org/uniprotkb/E1B8J9", "locus": { "chromosome": "11", "start_pos": 99626771, "end_pos": 99629712, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030521", "url": "https://www.ensembl.org/id/ENSBTAG00000030521" } ] } } ], "crossref": [ { "id": "E1B8J9", "url": "https://alphafold.ebi.ac.uk/entry/E1B8J9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030521", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030521", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782019", "url": "https://www.ncbi.nlm.nih.gov/gene/782019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782019", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDCCCDA", "url": "https://omabrowser.org/oma/group/QDCCCDA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8J9", "url": "https://www.orthodb.org/?gene=E1B8J9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15895", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15895", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05760", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05760", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193764", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8J9", "url": "https://www.uniprot.org/uniprotkb/E1B8J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8J9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8J9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPVARHQLHQLHQLHQLHLQQQLHQHPAPRGCAAAAAAGAPAGGAGALSELPGCAALQPPHGAPHRGQPLEPLQPGPAPLPPPASLCPRDPRASAACSAPSAPPGAAPQAAAAASPPSSPAPASSPGFYRGAYPAPSDFGVHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASATGCKRKYYPGQEEEDDDDEDAGDLGAEPPGGVPFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF", "length": 402, "header": "tr|E1B8J9-1|E1B8J9_BOVIN Isoform 1 of Immediate early response 5 like OS=Bos taurus OX=9913 GN=IER5L PE=3 SV=2 CANONICAL=E1B8J9-1" }, "isoforms": [ { "isoform_ac": "E1B8J9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8J9/entry", "sequence": { "sequence": "MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPVARHQLHQLHQLHQLHLQQQLHQHPAPRGCAAAAAAGAPAGGAGALSELPGCAALQPPHGAPHRGQPLEPLQPGPAPLPPPASLCPRDPRASAACSAPSAPPGAAPQAAAAASPPSSPAPASSPGFYRGAYPAPSDFGVHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASATGCKRKYYPGQEEEDDDDEDAGDLGAEPPGGVPFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF", "length": 402, "header": "tr|E1B8J9-1|E1B8J9_BOVIN Isoform 1 of Immediate early response 5 like OS=Bos taurus OX=9913 GN=IER5L PE=3 SV=2 CANONICAL=E1B8J9-1" }, "locus": { "chromosome": "11", "start_pos": 99628982, "end_pos": 99627777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043070.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043070.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040665.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040665.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782019", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782019", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AVA4-1", "protein_name": "Immediate early response 5 like", "gene_name": "IER5L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPAARHQLHQLHQLHQLHLQQQLHQHQHPAPRGCAAAAGAPAGGAGALSELPGCAALQPPHGAPHRGQPLEPLQPGPAPLPPPAPAALCPRDPRASAACSAPSAPPGAAPQAAAAASPPASPAPASSPGFYRGAYPAPSDFGVHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASAAGCKRKYYPGQEEEDDDDDAGDLGAEPPGGATFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF", "length": 403 }, "evidence": [ { "id": "E1B8J9", "url": "https://omabrowser.org/oma/group/E1B8J9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5PQP0-1", "protein_name": "Immediate early response gene 5-like protein", "gene_name": "Ier5l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPVARHQLHQLHQLHQLHLQQQLHQHQHPAPRGCTAAAPVAVAGAPAGCAGALSELPGCAALQPPHGAPHRGQHLEPLQPGPAPLPPPAPAALCPRDPRVPAACSAPSAPPGAAPPTVAASSPPASPAPSSSPGFYRGAYPAPSDFGVHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASAAGCKRKYYPGQEEEDDEEEDAGDLGAEPPGGTPFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF", "length": 409 }, "evidence": [ { "id": "E1B8J9", "url": "https://omabrowser.org/oma/group/E1B8J9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T953-1", "protein_name": "Immediate early response gene 5-like protein", "gene_name": "IER5L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPAARHQLHQLHQLHQLHLQQQLHQHQHPAPRGCAAAAAAGAPAGGAGALSELPGCAALQPPHGAPHRGQPLEPLQPGPAPLPLPLPPPAPAALCPRDPRAPAACSAPPGAAPPAAAASPPASPAPASSPGFYRGAYPTPSDFGLHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASAAGCKRKYYPGQEEEEDDEEDAGGLGAEPPGGAPFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF", "length": 404 }, "evidence": [ { "id": "E1B8J9", "url": "https://omabrowser.org/oma/group/E1B8J9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6NYT3-1", "protein_name": "Immediate early response gene 5-like protein", "gene_name": "ier5l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYMNEKYAEIYRMQQYEEVMTVCNEIQELNPLDLAEDCEDQTADCCGSASESASLCGALLPAVGHQTSPAAQHIQPASACSVPLALQSEEVCKAAPEPSFYRSCCAEAYPVSNCDFSPVNNMHCNKTTVLDLDTHVVTTVENGYLHQDCCASLQQCCQGAQSPAKKRKLDFGYYVSEIEEAPDFTPCKRAKFEDSSYAITEPLDTSNISNLISIFGSGFSGLVSRQADLEQALNGQFCSKQALASLGAWTRAIVAF", "length": 301 }, "evidence": [ { "id": "E1B8J9", "url": "https://omabrowser.org/oma/group/E1B8J9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99J55-1", "protein_name": "Immediate early response gene 5-like protein", "gene_name": "Ier5l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPVARHQLHQLHQLHQLHLQQQLHQHQHPAPRGCTAAAPVAVAGAPAGCAGALSELPGCAALQPPHGAPHRGQHLEPLQPGPAPLPPPAPAALCPRDPRVPAACSAPSVLPGAAPSTVAASSPPASTAPSSSTGFYRGAYPAPSDFGVHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASAAGCKRKYYPGQEEEDDEEDAGDLGAEPPGGTPFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF", "length": 406 }, "evidence": [ { "id": "E1B8J9", "url": "https://omabrowser.org/oma/group/E1B8J9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8J9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 402, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8J9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8J9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 350, "end_pos": 352 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8L3-1", "uniprot_ac": "E1B8L3", "uniprot_id": "E1B8L3_BOVIN", "mass": { "chemical_mass": 80651.0, "monoisotopic_mass": 80651.0 }, "refseq": { "ac": "XP_010815894", "name": "interleukin-17 receptor E isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815894" }, "gene_names": [ { "name": "IL17RE", "type": "recommended", "evidence": [ { "id": "E1B8L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8L3" } ] }, { "name": "IL17RE", "type": "synonym", "evidence": [ { "id": "XP_010815894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815894" } ] } ], "protein_names": [ { "name": "Interleukin-17 receptor E", "type": "recommended", "evidence": [ { "id": "E1B8L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8L3/entry#names_and_taxonomy" } ] }, { "name": "interleukin-17 receptor E isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010815894", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815894" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8L3", "url": "https://www.uniprot.org/uniprotkb/E1B8L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL17RE", "url": "https://www.uniprot.org/uniprotkb/E1B8L3", "locus": { "chromosome": "22", "start_pos": 16840732, "end_pos": 16854624, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010833", "url": "https://www.ensembl.org/id/ENSBTAG00000010833" } ] } } ], "crossref": [ { "id": "E1B8L3", "url": "https://alphafold.ebi.ac.uk/entry/E1B8L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010833", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010833", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783335", "url": "https://www.ncbi.nlm.nih.gov/gene/783335", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8L3", "url": "https://www.orthodb.org/?gene=E1B8L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15583", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15583", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15583:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15583:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08357", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08357", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010815894", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815894", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NMI8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NMI8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQR5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQR5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8L3", "url": "https://www.uniprot.org/uniprotkb/E1B8L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8L3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWPGWLVGNEEELWGRAGQGQAEARAPAGTALPAAAQQAGPGPAAHLRAVQPCTGRLDPTEPHGEPQTGSPAPASSPAAHWPVCLCWDWLPLPSPLEYSLSTGLPHGKDGSFTGRSAQIPHHIQPAPHLSPKPWCACCCHCPHCWCLHLVSGPSGLQWGWLRLLVQKSEKSYKFWLCRRHRMPASAQRKLLSSCCLSEKGHHNSSLSPDSSHKGLRSKRTQPVDPEAGEGLSRSGSQKLGGPEFSFDLLPETRAIQVTIPPGPEVSVRLCHQWALECEDLSHPFDAQKIVPGSHTVDLPYEFLLPCLCIEASYLQEDTVRRKKCPFQDQPEAYGSDFWESMNFTDHSQHNQMVMAVTLRCPLKLEASLCQRRGWPTLCEDLPNAMARESEGWYVVEKVDLHPQLCFKFSFGNSSHVECPHRTFAAPSWNVSMDTQAQQVVLHFSSRTHVTFSAAWNHPGLGQDSVVPPVYSVSQTQGSTPVTLDLIVPFLRPGGCVLVWRSDVQFAWKRLLCPDVSHRRLGLLILALLAFTTLLGVVLVLTCRRPLSGPERAPPVLLLHVAESEAQRRLVGALAELLRAALGGGRDVIVDLWEGTRVARVGPLPWLWAARARVARERGTVVLLWSSAGPSPTGGPDPRAAPLRALLRAAPRPLLLLVYFSRLCAKGDIPPPLRALPRYRLLHDLPRLLRALDARASTEATTRGRFVAQPRLRGRVELCRRLELEAAKLADQG", "length": 732, "header": "tr|E1B8L3-1|E1B8L3_BOVIN Isoform 1 of Interleukin-17 receptor E OS=Bos taurus OX=9913 GN=IL17RE PE=4 SV=3 CANONICAL=E1B8L3-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NMI8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMI8/entry", "sequence": { "sequence": "MSRRKPWDDGEGPHREQSLVSIGNHRKPAAHWPVCLCWDWLPLPSPLEYSLSTGLPHGKDGSFTGRSAQIPHHIQPAPHLSPKPWCACCCHCPHCWCLHLVSGPSGLQWGWLRLLVQKSEKSYKFWLCRRHRMPASAQRKLLSSCCLSEKGHHNSSLSPDSSHKGLRSKRTQPVDPEAGEGLSRSGSQKLGGPEFSFDLLPETRAIQVTIPPGPEVSVRLCHQWALECEDLSHPFDAQKIVPGSHTVDLPYEFLLPCLCIEASYLQEDTVRRKKCPFQDQPEAYGSDFWESMNFTDHSQHNQMVMAVTLRCPLKLEASLCQRRGWPTLCEDLPNAMARESEGWYVVEKVDLHPQLCFKFSFGNSSHVECPHRTFAAPSWNVSMDTQAQQVVLHFSSRTHVTFSAAWNHPGLGQDSVVPPVYSVSQTQGSTPVTLDLIVPFLRPGGCVLVWRSDVQFAWKRLLCPDVSHRRLGLLILALLAFTTLLGVVLVLTCRRPLSGPERAPPVLLLHVAESEAQRRLVGALAELLRAALGGGRDVIVDLWEGTRVARVGPLPWLWAARARVARERGTVVLLWSSAGPSPTGGPDPRAAPLRALLRAAPRPLLLLVYFSRLCAKGDIPPPLRALPRYRLLHDLPRLLRALDARASTEATTRGRFVAQPRLRGRVELCRRLELEAAKLADQG", "length": 683, "header": "tr|A0ABI0NMI8-1|A0ABI0NMI8_BOVIN Computationally mapped isoform of Interleukin-17 receptor E OS=Bos taurus OX=9913 GN=IL17RE PE=4 SV=1 CANONICAL=E1B8L3-1" }, "locus": { "chromosome": "22", "start_pos": 16852418, "end_pos": 16841736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139602.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139602.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106714.1" } ] } }, { "isoform_ac": "A0ABI0NQR5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQR5/entry", "sequence": { "sequence": "MWPGWLVGNEEELWGRAGQGQAEARAPAGTALPAAAQQAGPGPAAHLRAVQPCTGRLDPTEPHGEPQTGSPAPASSPAAHWPVCLCWDWLPLPSPLEYSLSTGLPHGLQWGWLRLLVQKSEKSYKFWLCRRHRMPASAQRKLLSSCCLSEKGHHNSSLSPDSSHKGLRSKRTQPVDPEAGEGLSRSGSQKLGGPEFSFDLLPETRAIQVTIPPGPEVSVRLCHQWALECEDLSHPFDAQKIVPGSHTVDLPYEFLLPCLCIEASYLQEDTVRRKKCPFQDQPEAYGSDFWESMNFTDHSQHNQMVMAVTLRCPLKLEASLCQRRGWPTLCEDLPNAMARESEGWYVVEKVDLHPQLCFKFSFGNSSHVECPHRTFAAPSWNVSMDTQAQQVVLHFSSRTHVTFSAAWNHPGLGQDSVVPPVYSVSQTQGSTPVTLDLIVPFLRPGGCVLVWRSDVQFAWKRLLCPDVSHRRLGLLILALLAFTTLLGVVLVLTCRRPLSGPERAPPVLLLHVAESEAQRRLVGALAELLRAALGGGRDVIVDLWEGTRVARVGPLPWLWAARARVARERGTVVLLWSSAGPSPTGGPDPRAAPLRALLRAAPRPLLLLVYFSRLCAKGDIPPPLRALPRYRLLHDLPRLLRALDARASTEATTRGRFVAQPRLRGRVELCRRLELEAAKLADQG", "length": 684, "header": "tr|A0ABI0NQR5-1|A0ABI0NQR5_BOVIN Computationally mapped isoform of Interleukin-17 receptor E OS=Bos taurus OX=9913 GN=IL17RE PE=4 SV=1 CANONICAL=E1B8L3-1" }, "locus": { "chromosome": "22", "start_pos": 16851772, "end_pos": 16841736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146450.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146450.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104662.1" } ] } }, { "isoform_ac": "E1B8L3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8L3/entry", "sequence": { "sequence": "MWPGWLVGNEEELWGRAGQGQAEARAPAGTALPAAAQQAGPGPAAHLRAVQPCTGRLDPTEPHGEPQTGSPAPASSPAAHWPVCLCWDWLPLPSPLEYSLSTGLPHGKDGSFTGRSAQIPHHIQPAPHLSPKPWCACCCHCPHCWCLHLVSGPSGLQWGWLRLLVQKSEKSYKFWLCRRHRMPASAQRKLLSSCCLSEKGHHNSSLSPDSSHKGLRSKRTQPVDPEAGEGLSRSGSQKLGGPEFSFDLLPETRAIQVTIPPGPEVSVRLCHQWALECEDLSHPFDAQKIVPGSHTVDLPYEFLLPCLCIEASYLQEDTVRRKKCPFQDQPEAYGSDFWESMNFTDHSQHNQMVMAVTLRCPLKLEASLCQRRGWPTLCEDLPNAMARESEGWYVVEKVDLHPQLCFKFSFGNSSHVECPHRTFAAPSWNVSMDTQAQQVVLHFSSRTHVTFSAAWNHPGLGQDSVVPPVYSVSQTQGSTPVTLDLIVPFLRPGGCVLVWRSDVQFAWKRLLCPDVSHRRLGLLILALLAFTTLLGVVLVLTCRRPLSGPERAPPVLLLHVAESEAQRRLVGALAELLRAALGGGRDVIVDLWEGTRVARVGPLPWLWAARARVARERGTVVLLWSSAGPSPTGGPDPRAAPLRALLRAAPRPLLLLVYFSRLCAKGDIPPPLRALPRYRLLHDLPRLLRALDARASTEATTRGRFVAQPRLRGRVELCRRLELEAAKLADQG", "length": 732, "header": "tr|E1B8L3-1|E1B8L3_BOVIN Isoform 1 of Interleukin-17 receptor E OS=Bos taurus OX=9913 GN=IL17RE PE=4 SV=3 CANONICAL=E1B8L3-1" }, "locus": { "chromosome": "22", "start_pos": 16851772, "end_pos": 16841736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014373.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014373.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014373.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014373.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" }, { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "reported site T583 is on non-canonical isoform A0ABI0NMI8-1 which maps to canonical isoform site E1B8L3-1:632", "icn3d_view": {}, "start_pos": 632, "start_aa": "Thr", "end_pos": 632, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr632", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8L3", "url": "https://www.uniprot.org/uniprotkb/E1B8L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "E1B8L3", "url": "https://www.uniprot.org/uniprotkb/E1B8L3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "interleukin-17 receptor activity", "id": "GO:0030368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030368", "evidence": [ { "database": "UniProtKB", "id": "E1B8L3", "url": "https://www.uniprot.org/uniprotkb/E1B8L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8L3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 732, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8L3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8L3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8L3" }, { "id": "PS51534", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51534" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEFIR", "eco_id": "ECO_0000259", "start_pos": 552, "end_pos": 689, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 632 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 412, "end_pos": 414 }, { "start_pos": 429, "end_pos": 431 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8L7-1", "uniprot_ac": "E1B8L7", "uniprot_id": "E1B8L7_BOVIN", "mass": { "chemical_mass": 12802.0, "monoisotopic_mass": 12802.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Large ribosomal subunit protein eL30", "type": "recommended", "evidence": [ { "id": "E1B8L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8L7/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L30", "type": "synonym", "evidence": [ { "id": "E1B8L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8L7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8L7", "url": "https://www.uniprot.org/uniprotkb/E1B8L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B8L7", "locus": {} } ], "crossref": [ { "id": "E1B8L7", "url": "https://alphafold.ebi.ac.uk/entry/E1B8L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040051", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040051", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HRVSCLS", "url": "https://omabrowser.org/oma/group/HRVSCLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11449", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11449", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B8L7", "url": "https://www.uniprot.org/uniprotkb/E1B8L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8L7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8L7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYMLGYKQTLKMIRQGKAKLVILTNNCPALRKSEIEYYAMLAKTGVHHYGGNNIELGTACGKYYRVCTLAIVDPGDSDIIRSMPEQTGEK", "length": 115, "header": "tr|E1B8L7-1|E1B8L7_BOVIN Isoform 1 of Large ribosomal subunit protein eL30 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1B8L7-1" }, "isoforms": [ { "isoform_ac": "E1B8L7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8L7/entry", "sequence": { "sequence": "MVAAKKTKKSLESINSRLQLVMKSGKYMLGYKQTLKMIRQGKAKLVILTNNCPALRKSEIEYYAMLAKTGVHHYGGNNIELGTACGKYYRVCTLAIVDPGDSDIIRSMPEQTGEK", "length": 115, "header": "tr|E1B8L7-1|E1B8L7_BOVIN Isoform 1 of Large ribosomal subunit protein eL30 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=E1B8L7-1" }, "locus": { "chromosome": "15", "start_pos": 31611941, "end_pos": 31611597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056935.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056935.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000052626.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q55BS9-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "rpl30", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVSVKKVKKSQENIGSKLALVMKSGKSQLGYKSTLKTLRAGKSKLILLASNLPSIRRSEIEYYAMLSKTTVHLYSGNNVDLGTALGRHYRVSVMSITDAGDSDILTALNAKA", "length": 112 }, "evidence": [ { "id": "E1B8L7", "url": "https://omabrowser.org/oma/group/E1B8L7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9C8F7-1", "protein_name": "Large ribosomal subunit protein eL30z", "gene_name": "RPL30A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVAAKKTKKSHEGINSRLALVMKSGKYTLGYKSVLKSLRSSKGKLILISSNCPPLRRSEIEYYAMLAKVGVHHYNRNNVDLGTACGKYFRVSCLSIVDPGDSDIIKSLPGDQ", "length": 112 }, "evidence": [ { "id": "E1B8L7", "url": "https://omabrowser.org/oma/group/E1B8L7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VJ19-1", "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "RpL30", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVAVKKQKKALESTNARLALVMKSGKYCLGYKQTLKTLRQGKAKLVLIASNTPALRKSEIEYYAMLAKTEVQHYSGTNIELGTACGKYFRVCTLSITDPGDSDIIRSLETA", "length": 111 }, "evidence": [ { "id": "E1B8L7", "url": "https://omabrowser.org/oma/group/E1B8L7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1B8L7", "url": "https://www.uniprot.org/uniprotkb/E1B8L7" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "E1B8L7", "url": "https://www.uniprot.org/uniprotkb/E1B8L7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "E1B8L7", "url": "https://www.uniprot.org/uniprotkb/E1B8L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8L7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 115, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8L7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8L7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8L7" }, { "id": "PF01248", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ribosomal protein eL8/eL30/eS12/Gadd45", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 105, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8Q1-1", "uniprot_ac": "E1B8Q1", "uniprot_id": "E1B8Q1_BOVIN", "mass": { "chemical_mass": 37832.0, "monoisotopic_mass": 37832.0 }, "refseq": { "ac": "XP_010814798", "name": "tetraspanin-10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814798" }, "gene_names": [ { "name": "TSPAN10", "type": "recommended", "evidence": [ { "id": "E1B8Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1" } ] }, { "name": "TSPAN10", "type": "synonym", "evidence": [ { "id": "XP_010814798", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814798" } ] } ], "protein_names": [ { "name": "Tetraspanin-10", "type": "recommended", "evidence": [ { "id": "E1B8Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1/entry#names_and_taxonomy" } ] }, { "name": "Oculospanin", "type": "synonym", "evidence": [ { "id": "E1B8Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-10", "type": "synonym", "evidence": [ { "id": "XP_010814798", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814798" } ] } ], "function": [ { "annotation": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1#function" }, { "database": "UniProtKB", "id": "ARBA00056995", "url": "https://www.uniprot.org/uniprotkb/ARBA00056995#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Q1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN10", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1", "locus": { "chromosome": "19", "start_pos": 51160969, "end_pos": 51166116, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040573", "url": "https://www.ensembl.org/id/ENSBTAG00000040573" } ] } } ], "crossref": [ { "id": "E1B8Q1", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040573", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040573", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617766", "url": "https://www.ncbi.nlm.nih.gov/gene/617766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617766", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617766", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B8Q1", "url": "https://www.orthodb.org/?gene=E1B8Q1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF550", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF550", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010814798", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814798", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8Q1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Q1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEGERSPLLSQEAGGQESLLAGSSPLTSSRPGLAPWEDPAWRAGFGGFLACLLPSESSCLKCLLFLSNFLFSLLSLLALAIGLWGLAVKGSLGSSWGSPLPADPMLGLVLGGLAVSVVSLAGCLGALCENTFLLRCFSGGVLAFLVLEAVVGALVVALWGQLQDGLEHVLRLAITHYQDDPDLCFLIDQVQLGLQCCGAASYQDWQWNLYFNCSSPGVQACSLPASCCVDPWEGGASVNDQCGFGALGLDEDAAQRVVHLEGCGPPLLQWLRSNIRTVGCYAIVVVLVQGVELLLAIQLVRALTVHKGAEGSGGLSGGTPDPVSHPLLNRSWSDQLGGQKTPKRCGLGPQASPPLPGHMSE", "length": 362, "header": "tr|E1B8Q1-1|E1B8Q1_BOVIN Isoform 1 of Tetraspanin-10 OS=Bos taurus OX=9913 GN=TSPAN10 PE=3 SV=3 CANONICAL=E1B8Q1-1" }, "isoforms": [ { "isoform_ac": "E1B8Q1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1/entry", "sequence": { "sequence": "MEEGERSPLLSQEAGGQESLLAGSSPLTSSRPGLAPWEDPAWRAGFGGFLACLLPSESSCLKCLLFLSNFLFSLLSLLALAIGLWGLAVKGSLGSSWGSPLPADPMLGLVLGGLAVSVVSLAGCLGALCENTFLLRCFSGGVLAFLVLEAVVGALVVALWGQLQDGLEHVLRLAITHYQDDPDLCFLIDQVQLGLQCCGAASYQDWQWNLYFNCSSPGVQACSLPASCCVDPWEGGASVNDQCGFGALGLDEDAAQRVVHLEGCGPPLLQWLRSNIRTVGCYAIVVVLVQGVELLLAIQLVRALTVHKGAEGSGGLSGGTPDPVSHPLLNRSWSDQLGGQKTPKRCGLGPQASPPLPGHMSE", "length": 362, "header": "tr|E1B8Q1-1|E1B8Q1_BOVIN Isoform 1 of Tetraspanin-10 OS=Bos taurus OX=9913 GN=TSPAN10 PE=3 SV=3 CANONICAL=E1B8Q1-1" }, "locus": { "chromosome": "19", "start_pos": 51165910, "end_pos": 51161795, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056667.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056667.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052614.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052614.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617766", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617766", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Q1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 362, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Q1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Q1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 }, { "start_pos": 330, "end_pos": 332 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8Q3-1", "uniprot_ac": "E1B8Q3", "uniprot_id": "E1B8Q3_BOVIN", "mass": { "chemical_mass": 7949.0, "monoisotopic_mass": 7949.0 }, "refseq": { "ac": "NP_001193261", "name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193261" }, "gene_names": [ { "name": "GNG13", "type": "recommended", "evidence": [ { "id": "E1B8Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ] }, { "name": "GNG13", "type": "synonym", "evidence": [ { "id": "NP_001193261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193261" } ] }, { "name": "HG3J", "type": "synonym", "evidence": [ { "id": "NP_001193261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193261" } ] } ], "protein_names": [ { "name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "type": "recommended", "evidence": [ { "id": "E1B8Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3/entry#names_and_taxonomy" } ] }, { "name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "type": "synonym", "evidence": [ { "id": "NP_001193261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193261" } ] }, { "name": "heterotrimeric guanine nucleotide-binding protein 3J", "type": "synonym", "evidence": [ { "id": "NP_001193261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193261" } ] } ], "function": [ { "annotation": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3#function" }, { "database": "UniProtKB", "id": "ARBA00002002", "url": "https://www.uniprot.org/uniprotkb/ARBA00002002#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNG13", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3", "locus": { "chromosome": "25", "start_pos": 676752, "end_pos": 679578, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061938", "url": "https://www.ensembl.org/id/ENSBTAG00000061938" } ] } } ], "crossref": [ { "id": "E1B8Q3", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Q3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033526", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033526", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00068", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00068", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517006", "url": "https://www.ncbi.nlm.nih.gov/gene/517006", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517006", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517006", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DEWDAPQ", "url": "https://omabrowser.org/oma/group/DEWDAPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8Q3", "url": "https://www.orthodb.org/?gene=E1B8Q3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15936", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15936", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15936:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15936:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00631", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00631", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296041", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202040", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202040", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381676", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381771", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381771", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392451", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392451", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392851", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392851", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-400042", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-400042", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086398", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418217", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418217", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418592", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418592", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418597", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-428930", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428930", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432040", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432040", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-456926", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-456926", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-500657", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-500657", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6814122", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8964315", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964315", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8964616", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964616", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9009391", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9009391", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9717207", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9856530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-997272", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193261", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Q3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEEGIPKDPFLNPDLMKNNPWVEKGKCAIL", "length": 67, "header": "tr|E1B8Q3-1|E1B8Q3_BOVIN Isoform 1 of Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 OS=Bos taurus OX=9913 GN=GNG13 PE=3 SV=1 CANONICAL=E1B8Q3-1" }, "isoforms": [ { "isoform_ac": "E1B8Q3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3/entry", "sequence": { "sequence": "MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEEGIPKDPFLNPDLMKNNPWVEKGKCAIL", "length": 67, "header": "tr|E1B8Q3-1|E1B8Q3_BOVIN Isoform 1 of Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 OS=Bos taurus OX=9913 GN=GNG13 PE=3 SV=1 CANONICAL=E1B8Q3-1" }, "locus": { "chromosome": "25", "start_pos": 678135, "end_pos": 677756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116359.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116359.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096258.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517006", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517006", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296041", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "resource": "Reactome", "description": "Activation of G protein gated Potassium channels" }, { "id": "R-BTA-202040", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202040", "resource": "Reactome", "description": "G-protein activation" }, { "id": "R-BTA-381676", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "resource": "Reactome", "description": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion" }, { "id": "R-BTA-381753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "resource": "Reactome", "description": "Olfactory Signaling Pathway" }, { "id": "R-BTA-381771", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381771", "resource": "Reactome", "description": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)" }, { "id": "R-BTA-392170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392170", "resource": "Reactome", "description": "ADP signalling through P2Y purinoceptor 12" }, { "id": "R-BTA-392451", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392451", "resource": "Reactome", "description": "G beta:gamma signalling through PI3Kgamma" }, { "id": "R-BTA-392851", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392851", "resource": "Reactome", "description": "Prostacyclin signalling through prostacyclin receptor" }, { "id": "R-BTA-400042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-400042", "resource": "Reactome", "description": "Adrenaline,noradrenaline inhibits insulin secretion" }, { "id": "R-BTA-4086398", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "resource": "Reactome", "description": "Ca2+ pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-418217", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418217", "resource": "Reactome", "description": "G beta:gamma signalling through PLC beta" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-418592", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418592", "resource": "Reactome", "description": "ADP signalling through P2Y purinoceptor 1" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-418597", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418597", "resource": "Reactome", "description": "G alpha (z) signalling events" }, { "id": "R-BTA-420092", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "resource": "Reactome", "description": "Glucagon-type ligand receptors" }, { "id": "R-BTA-428930", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428930", "resource": "Reactome", "description": "Thromboxane signalling through TP receptor" }, { "id": "R-BTA-432040", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432040", "resource": "Reactome", "description": "Vasopressin regulates renal water homeostasis via Aquaporins" }, { "id": "R-BTA-456926", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-456926", "resource": "Reactome", "description": "Thrombin signalling through proteinase activated receptors (PARs)" }, { "id": "R-BTA-500657", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-500657", "resource": "Reactome", "description": "Presynaptic function of Kainate receptors" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" }, { "id": "R-BTA-8964315", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964315", "resource": "Reactome", "description": "G beta:gamma signalling through BTK" }, { "id": "R-BTA-8964616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964616", "resource": "Reactome", "description": "G beta:gamma signalling through CDC42" }, { "id": "R-BTA-9009391", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9009391", "resource": "Reactome", "description": "Extra-nuclear estrogen signaling" }, { "id": "R-BTA-9717207", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9717207", "resource": "Reactome", "description": "Sensory perception of sweet, bitter, and umami (glutamate) taste" }, { "id": "R-BTA-9856530", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856530", "resource": "Reactome", "description": "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells" }, { "id": "R-BTA-997272", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "resource": "Reactome", "description": "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SYH6-1", "protein_name": "G protein subunit gamma 13", "gene_name": "GNG13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEWDVPQMKKEVESLKYQLAFQRETSSKTIPELLKWIEEGIPKDPFLNPDLMKSNPWVEKGKCAIL", "length": 67 }, "evidence": [ { "id": "E1B8Q3", "url": "https://omabrowser.org/oma/group/E1B8Q3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LYM2-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "gene_name": "Gng13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKAKCTIL", "length": 67 }, "evidence": [ { "id": "E1B8Q3", "url": "https://omabrowser.org/oma/group/E1B8Q3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Z7U6-1", "protein_name": "G protein subunit gamma 13", "gene_name": "GNG13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLFHQAFKAAWRIRFLSYNPEGTPLLWQHQPPLSPSAMDEWDLSQWKKEVESLKYQLAYKREMSSKTIPEFVKWIEDGIPEDPFLNPELMKNNPWVEKGKCSIL", "length": 105 }, "evidence": [ { "id": "E1B8Q3", "url": "https://omabrowser.org/oma/group/E1B8Q3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9JMF3-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "gene_name": "Gng13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKAKCTIL", "length": 67 }, "evidence": [ { "id": "E1B8Q3", "url": "https://omabrowser.org/oma/group/E1B8Q3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2W3-1", "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "gene_name": "GNG13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEWDVPQMKKEVESLKYQLAFQREMASKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKGKCTIL", "length": 67 }, "evidence": [ { "id": "E1B8Q3", "url": "https://omabrowser.org/oma/group/E1B8Q3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G-protein beta-subunit binding", "id": "GO:0031681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031681", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" }, { "name": "sensory perception of taste", "id": "GO:0050909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050909", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" }, { "name": "heterotrimeric G-protein complex", "id": "GO:0005834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005834", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q3", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Q3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 67, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Q3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Q3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q3" }, { "id": "PS50058", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50058" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G protein gamma", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 67, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8T2-1", "uniprot_ac": "E1B8T2", "uniprot_id": "E1B8T2_BOVIN", "mass": { "chemical_mass": 60152.0, "monoisotopic_mass": 60152.0 }, "refseq": { "ac": "NP_001180022", "name": "solute carrier family 22 member 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180022" }, "gene_names": [ { "name": "SLC22A15", "type": "recommended", "evidence": [ { "id": "E1B8T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8T2" } ] }, { "name": "SLC22A15", "type": "synonym", "evidence": [ { "id": "NP_001180022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180022" } ] } ], "protein_names": [ { "name": "Solute carrier family 22 member 15", "type": "synonym", "evidence": [ { "id": "E1B8T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8T2/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 22 member 15", "type": "synonym", "evidence": [ { "id": "NP_001180022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180022" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8T2", "url": "https://www.uniprot.org/uniprotkb/E1B8T2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC22A15", "url": "https://www.uniprot.org/uniprotkb/E1B8T2", "locus": { "chromosome": "3", "start_pos": 27260580, "end_pos": 27363346, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000664", "url": "https://www.ensembl.org/id/ENSBTAG00000000664" } ] } } ], "crossref": [ { "id": "E1B8T2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8T2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000664", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000664", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17377", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17377", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512417", "url": "https://www.ncbi.nlm.nih.gov/gene/512417", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512417", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512417", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FPMETRA", "url": "https://omabrowser.org/oma/group/FPMETRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8T2", "url": "https://www.orthodb.org/?gene=E1B8T2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-549127", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-549127", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001180022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180022", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8T2", "url": "https://www.uniprot.org/uniprotkb/E1B8T2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8T2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8T2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHSNQSAGEDQALGAWLLTANGSEMHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVITFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLSIPESPRWLYSQGRLLEAEAALRLIAKRNRQLRCSFSLARPAGGSCEEAGSVLDLFRRRVLLGHTLTLMFIWFVCSLVYYGLTLSAGDLGGNIYANLALSGLIEIPSYPVCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQTLDPPQSVDKESPLGSESDEEEEFYDADEETQMIK", "length": 547, "header": "tr|E1B8T2-1|E1B8T2_BOVIN Isoform 1 of Solute carrier family 22 member 15 OS=Bos taurus OX=9913 GN=SLC22A15 PE=4 SV=2 CANONICAL=E1B8T2-1" }, "isoforms": [ { "isoform_ac": "E1B8T2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8T2/entry", "sequence": { "sequence": "MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHSNQSAGEDQALGAWLLTANGSEMHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVITFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLSIPESPRWLYSQGRLLEAEAALRLIAKRNRQLRCSFSLARPAGGSCEEAGSVLDLFRRRVLLGHTLTLMFIWFVCSLVYYGLTLSAGDLGGNIYANLALSGLIEIPSYPVCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQTLDPPQSVDKESPLGSESDEEEEFYDADEETQMIK", "length": 547, "header": "tr|E1B8T2-1|E1B8T2_BOVIN Isoform 1 of Solute carrier family 22 member 15 OS=Bos taurus OX=9913 GN=SLC22A15 PE=4 SV=2 CANONICAL=E1B8T2-1" }, "locus": { "chromosome": "3", "start_pos": 27363147, "end_pos": 27261021, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000874.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000874.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000874.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000874.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 45, "start_aa": "Thr", "end_pos": 45, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512417", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512417", "resource": "KEGG Pathway" }, { "id": "R-BTA-549127", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-549127", "resource": "Reactome", "description": "SLC-mediated transport of organic cations" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A271-1", "protein_name": "Solute carrier family 22, member 15", "gene_name": "Slc22a15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVEEAFQAVGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYHWDMAELLPNQSHSNQSSGKGQAFGDWLLTANGSEIHKHVHFSNSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSYRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQMYSYRRLGEEALSLQTLDPPQPLGKASSLGSESEEEEEEFYDANEETQMIK", "length": 548 }, "evidence": [ { "id": "E1B8T2", "url": "https://omabrowser.org/oma/group/E1B8T2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HJE9-1", "protein_name": "Solute carrier family 22 member 15 isoform X1", "gene_name": "Slc22a15", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEVEEAFQAVGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPSYHWDMAELLPNQSHSNQSDGKDQAFGAWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGVMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAVLVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGACSMFSRVGGIIAPFIPSLKDLQWSLPFIVFGATGLASGLLSLLLPETLNSPLLETFSDLQMYSYRRLGEEALSLQTLDPPQALDKASTLGSESEEEEFYDADEETQMIK", "length": 546 }, "evidence": [ { "id": "E1B8T2", "url": "https://omabrowser.org/oma/group/E1B8T2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q504N2-1", "protein_name": "Solute carrier family 22 member 15", "gene_name": "Slc22a15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVEEAFQAVGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYHWDMADLLPNQSHSNQTLGKGQAFGDWLLTANGSEIHKHVHFSNSFTSIASEWFLIANRSYKVSAASSSFFSGVFVGVISFGQLSDRFGRRKVYLTGFALDILFAVANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAVLVNLQGTLVFLLSLFIPESPRWLYSQGRLSEAEEALYFIAKRNRKLKCTFSLTHPANRSYRATGSFLDLFRYRILLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGACSMFSRVGGIIAPFVPSLKEVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQMYSYRRLGEEALSLQTLDPPQPLDKVSSESEEEEEFYDADEETQMIK", "length": 544 }, "evidence": [ { "id": "E1B8T2", "url": "https://omabrowser.org/oma/group/E1B8T2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZD6-1", "protein_name": "Solute carrier family 22 member 15", "gene_name": "SLC22A15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDADEETQMIK", "length": 547 }, "evidence": [ { "id": "E1B8T2", "url": "https://omabrowser.org/oma/group/E1B8T2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "amino-acid betaine transmembrane transporter activity", "id": "GO:0015199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015199", "evidence": [ { "database": "UniProtKB", "id": "E1B8T2", "url": "https://www.uniprot.org/uniprotkb/E1B8T2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8T2", "url": "https://www.uniprot.org/uniprotkb/E1B8T2" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1B8T2", "url": "https://www.uniprot.org/uniprotkb/E1B8T2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8T2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 547, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8T2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8T2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8T2" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 486, "start_aa": "Cys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 45 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 58, "end_pos": 60 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8U3-1", "uniprot_ac": "E1B8U3", "uniprot_id": "E1B8U3_BOVIN", "mass": { "chemical_mass": 215288.0, "monoisotopic_mass": 215288.0 }, "refseq": {}, "gene_names": [ { "name": "GREB1", "type": "recommended", "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" } ] } ], "protein_names": [ { "name": "Growth regulating estrogen receptor binding 1", "type": "synonym", "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8U3", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GREB1", "url": "https://www.uniprot.org/uniprotkb/E1B8U3", "locus": { "chromosome": "11", "start_pos": 86232072, "end_pos": 86302050, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015402", "url": "https://www.ensembl.org/id/ENSBTAG00000015402" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015402", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015402", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8U3", "url": "https://www.orthodb.org/?gene=E1B8U3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15720", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15720", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15720:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15720:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20267", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20267", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20688", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20688", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20691", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20691", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20692", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20692", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9018519", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B8U3", "url": "https://www.uniprot.org/uniprotkb/E1B8U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNSYAGQLKTTRFEEVLHNSIEASLRSNSLVPRPIFSQLYLEAEQQLSALEGGSRVDNEEEEEEGDGGLEQNCPPNPYQMHPPPEGCCTTDGFCQAGKDLRLVSISSEPIDIPAGFLLVGAKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGCGKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGALTKGPLICWKGSEFRSRQASMGACSSSLFPPLDSSGPPAPFPGEPGPGTAPSAPLGAPQAGPASEHPALTAALGLAVFNGKDSPKHQPLVKNRLSAVPRPSALGILSNSGPPKKRHKGWSPESPSASDGGYPQGGGHRAKYESAGVTCMPQVGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHGNFPYLCGNLNDVVVSPLLYTCYQNSQSISRAYEQYGASTIQPISEEMQLLLTVYYLVQLAADQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPVPGAVAPVTSAQLPWLAGLAASSCNDSVHIIECTYSLAEGLSEMFRLLIEGKLAKTNYVVIICACRSAAIDSCIAVTGKYQARILSESLLTPAEYQKEVNYELVTGKVDSLGAFFSTLCPEGDIDILLDKFHQENQGLVSSSLTASSVTKSASLDVSGAPACTSYHLEPHRIRPFQLAVAQKLLSHVCSIADSSTQNLDLGSFEKVDFLICIPPSEVTYQQTLFHVWHSGVLLELGLEKEHVTRQRVEQYVLKLDAEAQTKFKSFLQNSFQNPHTLFVLIHDHAHWDLVSAVHNLYSQSDPSVGLVDRLLNCKEVKEAPNIVTLHVTSFPYALQTQHTLVSPYNEIHWPASYSDGVDLYPENKKYFGLSEFIESTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAAMMAVSGLSQMKNYTSVETLEITQNLINSPKQCPCGHGLMVLLRVPCSPLAAVAYERLAHVRARLALEEHFEIILGNPASGITIGKHFLKQLKVWQNIEDAEWRPQTYLELEGLPCILIFSGMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSSEAPLEKGARTEALESDAEKLSSTDNEDEELVTEGSTSEKRSPVKRERSCSHDSASSSLSSKASSSAPCGESSAGPSQVERARSPPSCGPSEEARAPGERQRLRAAGGPPSVISRHSPGLTPQPDPSLKSGQHVQVSAPSASSSGSASSPALPAAGALVLQASQCSMTKACRQPPVVFLPKLVYDMVTSTDGSGLPKAASLLPSHSVMWASSFRPLLSKTMTSTEQSLYYRQWTVPRPGHMDYGNRAESRVDGFHPRRLLLSGPPQIGKTGAYLQFLSILSRMLIRLTEVDVYDEEEININLREDSDWHYLQLSDPWPDLELFKKLPFDYIIHDPKYEDASLICSHHQSVKSEDRGTHRKPEDLYVRRQTARMRLSKFAAYNTYHHCEQCHQYMGFHPRYQLYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEYIKSPTFTPTTGRHEHGLFNLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHFLIKELSYHNLELERNRQEELGIKPQDIWPFIVISDDSCVMWNVVDVDSGGERSREFSWSERNVSLKHIMQHIEASPNITHYALIGMRKWSSKTGSHEVREPFSRCHVHDFIVLNVDLTQNVQYNQNRFMCDDVDFNLRVHSAGLLLCRFNRFSVMKKQISVGGHRSFHITSKVSDSPMAVVPAQYICAPDSKHTFLAAPAQLLLEKFLQHHSHRFFPLSLKNLGHPVLSVDCYLNLGSQISVCYVSSRPHSLNISCSDFVFSGLLLYLCDSFVGASFLKKFHFLKGATLCVICQDRNSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTGRHI", "length": 1942, "header": "tr|E1B8U3-1|E1B8U3_BOVIN Isoform 1 of Growth regulating estrogen receptor binding 1 OS=Bos taurus OX=9913 GN=GREB1 PE=3 SV=4 CANONICAL=E1B8U3-1" }, "isoforms": [ { "isoform_ac": "E1B8U3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U3/entry", "sequence": { "sequence": "MGNSYAGQLKTTRFEEVLHNSIEASLRSNSLVPRPIFSQLYLEAEQQLSALEGGSRVDNEEEEEEGDGGLEQNCPPNPYQMHPPPEGCCTTDGFCQAGKDLRLVSISSEPIDIPAGFLLVGAKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGCGKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGALTKGPLICWKGSEFRSRQASMGACSSSLFPPLDSSGPPAPFPGEPGPGTAPSAPLGAPQAGPASEHPALTAALGLAVFNGKDSPKHQPLVKNRLSAVPRPSALGILSNSGPPKKRHKGWSPESPSASDGGYPQGGGHRAKYESAGVTCMPQVGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHGNFPYLCGNLNDVVVSPLLYTCYQNSQSISRAYEQYGASTIQPISEEMQLLLTVYYLVQLAADQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPVPGAVAPVTSAQLPWLAGLAASSCNDSVHIIECTYSLAEGLSEMFRLLIEGKLAKTNYVVIICACRSAAIDSCIAVTGKYQARILSESLLTPAEYQKEVNYELVTGKVDSLGAFFSTLCPEGDIDILLDKFHQENQGLVSSSLTASSVTKSASLDVSGAPACTSYHLEPHRIRPFQLAVAQKLLSHVCSIADSSTQNLDLGSFEKVDFLICIPPSEVTYQQTLFHVWHSGVLLELGLEKEHVTRQRVEQYVLKLDAEAQTKFKSFLQNSFQNPHTLFVLIHDHAHWDLVSAVHNLYSQSDPSVGLVDRLLNCKEVKEAPNIVTLHVTSFPYALQTQHTLVSPYNEIHWPASYSDGVDLYPENKKYFGLSEFIESTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAAMMAVSGLSQMKNYTSVETLEITQNLINSPKQCPCGHGLMVLLRVPCSPLAAVAYERLAHVRARLALEEHFEIILGNPASGITIGKHFLKQLKVWQNIEDAEWRPQTYLELEGLPCILIFSGMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSSEAPLEKGARTEALESDAEKLSSTDNEDEELVTEGSTSEKRSPVKRERSCSHDSASSSLSSKASSSAPCGESSAGPSQVERARSPPSCGPSEEARAPGERQRLRAAGGPPSVISRHSPGLTPQPDPSLKSGQHVQVSAPSASSSGSASSPALPAAGALVLQASQCSMTKACRQPPVVFLPKLVYDMVTSTDGSGLPKAASLLPSHSVMWASSFRPLLSKTMTSTEQSLYYRQWTVPRPGHMDYGNRAESRVDGFHPRRLLLSGPPQIGKTGAYLQFLSILSRMLIRLTEVDVYDEEEININLREDSDWHYLQLSDPWPDLELFKKLPFDYIIHDPKYEDASLICSHHQSVKSEDRGTHRKPEDLYVRRQTARMRLSKFAAYNTYHHCEQCHQYMGFHPRYQLYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEYIKSPTFTPTTGRHEHGLFNLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHFLIKELSYHNLELERNRQEELGIKPQDIWPFIVISDDSCVMWNVVDVDSGGERSREFSWSERNVSLKHIMQHIEASPNITHYALIGMRKWSSKTGSHEVREPFSRCHVHDFIVLNVDLTQNVQYNQNRFMCDDVDFNLRVHSAGLLLCRFNRFSVMKKQISVGGHRSFHITSKVSDSPMAVVPAQYICAPDSKHTFLAAPAQLLLEKFLQHHSHRFFPLSLKNLGHPVLSVDCYLNLGSQISVCYVSSRPHSLNISCSDFVFSGLLLYLCDSFVGASFLKKFHFLKGATLCVICQDRNSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTGRHI", "length": 1942, "header": "tr|E1B8U3-1|E1B8U3_BOVIN Isoform 1 of Growth regulating estrogen receptor binding 1 OS=Bos taurus OX=9913 GN=GREB1 PE=3 SV=4 CANONICAL=E1B8U3-1" }, "locus": { "chromosome": "11", "start_pos": 86301851, "end_pos": 86233076, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020468.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020468.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020468.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020468.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9018519", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "resource": "Reactome", "description": "Estrogen-dependent gene expression" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B8U3", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "E1B8U3", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1054, "end_pos": 1056, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1665, "end_pos": 1667, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1680, "end_pos": 1682, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1856, "end_pos": 1858, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 924, "end_pos": 926, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" }, { "id": "PF15782", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15782" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GREB1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 211, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" }, { "id": "PF20267", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20267" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GREB1-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 1780, "end_pos": 1942, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" }, { "id": "PF20692", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20692" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GREB1-like circularly permuted SF2 helicase", "eco_id": "ECO_0000259", "start_pos": 661, "end_pos": 1370, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" }, { "id": "PF20688", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20688" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GREB1-like second", "eco_id": "ECO_0000259", "start_pos": 305, "end_pos": 608, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U3" }, { "id": "PF20691", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20691" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TET-Associated Glycosyltransferase", "eco_id": "ECO_0000259", "start_pos": 1538, "end_pos": 1765, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1054, "end_pos": 1056 }, { "start_pos": 1665, "end_pos": 1667 }, { "start_pos": 1680, "end_pos": 1682 }, { "start_pos": 1856, "end_pos": 1858 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 924, "end_pos": 926 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8V4-1", "uniprot_ac": "E1B8V4", "uniprot_id": "E1B8V4_BOVIN", "mass": { "chemical_mass": 61155.0, "monoisotopic_mass": 61155.0 }, "refseq": { "ac": "NP_001179347", "name": "zinc finger protein 697", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179347" }, "gene_names": [ { "name": "ZNF697", "type": "recommended", "evidence": [ { "id": "E1B8V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ] }, { "name": "ZNF697", "type": "synonym", "evidence": [ { "id": "NP_001179347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179347" } ] } ], "protein_names": [ { "name": "Zinc finger protein 697", "type": "synonym", "evidence": [ { "id": "E1B8V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8V4/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 697", "type": "synonym", "evidence": [ { "id": "NP_001179347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179347" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF697", "url": "https://www.uniprot.org/uniprotkb/E1B8V4", "locus": { "chromosome": "3", "start_pos": 23692443, "end_pos": 23660102, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032187", "url": "https://www.ensembl.org/id/ENSBTAG00000032187" } ] } } ], "crossref": [ { "id": "E1B8V4", "url": "https://alphafold.ebi.ac.uk/entry/E1B8V4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032187", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032187", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540379", "url": "https://www.ncbi.nlm.nih.gov/gene/540379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540379", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540379", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDKQGVC", "url": "https://omabrowser.org/oma/group/EDKQGVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8V4", "url": "https://www.orthodb.org/?gene=E1B8V4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8V4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8V4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQDDKQGVCEAQDSQDKGMGSDFENCEDREGDPDERGMGSNPQDADKREGHLGQEMGSDPQDEAPRGHSEERELMSNICTEGLLSEEDGVASREEEDDQSGVVEMAMFPGLSESDSISRSPQEEEEEESAGENRLEEEEEQPPPAVLPWRRHLSLGSRHRGDKPAHRRFRRLHHPMSMDLGELDSLMASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAAASLEPFGFAGECEAVVGMMGVGGGFGAGPALARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSWRADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAASGAGPAALRPFACGECGKGFVRRSHLANHQRIHTGEKPHGCSECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTLTQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC", "length": 550, "header": "tr|E1B8V4-1|E1B8V4_BOVIN Isoform 1 of Zinc finger protein 697 OS=Bos taurus OX=9913 GN=ZNF697 PE=3 SV=1 CANONICAL=E1B8V4-1" }, "isoforms": [ { "isoform_ac": "E1B8V4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8V4/entry", "sequence": { "sequence": "MEQDDKQGVCEAQDSQDKGMGSDFENCEDREGDPDERGMGSNPQDADKREGHLGQEMGSDPQDEAPRGHSEERELMSNICTEGLLSEEDGVASREEEDDQSGVVEMAMFPGLSESDSISRSPQEEEEEESAGENRLEEEEEQPPPAVLPWRRHLSLGSRHRGDKPAHRRFRRLHHPMSMDLGELDSLMASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAAASLEPFGFAGECEAVVGMMGVGGGFGAGPALARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSWRADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAASGAGPAALRPFACGECGKGFVRRSHLANHQRIHTGEKPHGCSECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTLTQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC", "length": 550, "header": "tr|E1B8V4-1|E1B8V4_BOVIN Isoform 1 of Zinc finger protein 697 OS=Bos taurus OX=9913 GN=ZNF697 PE=3 SV=1 CANONICAL=E1B8V4-1" }, "locus": { "chromosome": "3", "start_pos": 23691439, "end_pos": 23687734, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054468.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054468.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048822.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048822.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540379", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540379", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480QPH8-1", "protein_name": "Zinc finger protein 697", "gene_name": "ZNF697", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQEDKQGVCGAQDSGDNGMGSDFENSEDGEGDSEERGMGSNPHDAAKTEGRPEQEMGSNPREEALRGHSEEKEVAPDICTAGLLSEEEGVALREEEDDPSGVAEMAMFPGLSESDSISRSFREEEEEEESAGENRLEDEEEQPTPPVLPWRRHLSLGSRHRGDKPAHRRFRRLHHPMAVDLGELDSLMASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAAASLEPFGFAGECGAVVGMMGVGVAGGFGAGPALARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSWRADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAASGAGPAALRPFACGECGKGFVRRSHLANHQRIHTGEKPHGCGECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTLTQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC", "length": 553 }, "evidence": [ { "id": "E1B8V4", "url": "https://omabrowser.org/oma/group/E1B8V4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4AA20-1", "protein_name": "Zinc finger protein 697", "gene_name": "Zfp697", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSFVQPHRKPQREGSGQPARVPARGPIAAASGRRAGARLGQCAQESPGASQGPCFPPCSLSCWMEQEDNLGVCADQSSEDRGMGSDFENSEDQEGDPEERGVGSNPQDTEERGHLEQELDSNPQDDDLRGDPPERDIVSTVCSEGLLSEEEGAILREEEDDQPGVADMALFPGLSESDSITRSPQGEEEEEEEEEEESAGENRLIEKEEPLPTPVLPWRRHLSLGGRHRGDKPAYRRFHRLHHPMAVDLGELDSLMASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAMASLEPFGLAGECGGVVGMMGVGMGVSGGFGAGPTLARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSWRADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAAGGAGSAAAAAAALRPFACGECGKGFVRRSHLANHQRIHTGEKPHGCGECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFSCGQCEKRFSDFSTLTQHQRTHTGEKPYTCLECGKSFIQSSHLIRHRRIHTGNKPHKCTGCGKGFRYKTHLAQHQKLHLC", "length": 627 }, "evidence": [ { "id": "E1B8V4", "url": "https://omabrowser.org/oma/group/E1B8V4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q569E7-1", "protein_name": "Zinc finger protein 697", "gene_name": "Znf697", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQEDNQGVCEYQTSEDRGMDSDLENSEDREGDPEERGMGSNPWDTEDRGHLEQEVDSNPQDDDLRGDSRERDRASTVCSEGRLSEEERAILREEEDDQPGVADMALFPGLSESDSISRSPRGEEDEEEEDEEEESAGENRLIEEEDPLPTPVLPWRRHLSLGGRHRGDKPAHRRFHRLHHPMAMDLGELDSLMASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAVASLEPFGLAGECGGVVGMMGMGMGVGMGVAGGFGAGPTLARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSWRADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAAGGGAGSAGSAAALRPFACGECGKGFVRRSHLANHQRIHTGEKPHGCGECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFGCGQCEKRFSDFSTLTQHQRTHTGEKPYTCLECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC", "length": 569 }, "evidence": [ { "id": "E1B8V4", "url": "https://omabrowser.org/oma/group/E1B8V4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5TEC3-1", "protein_name": "Zinc finger protein 697", "gene_name": "ZNF697", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKQEDNQGVCAHQDSEDKGMGSDFEDSEDREGDPEEREMGSNPHDTNKREGHPEPEMGSNPQDSRHREAVPDICTEGQLSEEEGVSVRGEEDDQSGVADMAMFPGLSESDSISRSLREDDDESAGENRLEEEEEQPAPPVLPWRRHLSLGSRHRGDKPAHRRFHRLHHPMAVDLGELDSLVASIMDAPTICPDCGESFSPGAAFLQHQRIHRLAEAAAAASLEPFGLAGECDAMVGMMGVGVAGGFGAGPPLARPPREKPFRCGECGKGFSRNTYLTNHLRLHTGERPNLCADCGKSFSWRADLLKHRRLHTGEKPYPCPECGEAFSLSSHLLSHRRAHAAASGAGAAALRPFACGECGKGFVRRSHLANHQRIHTGEKPHGCGECGKRFSWRSDLVKHQRVHTGEKPYMCSECGETFSVSSHLFTHKRTHSGERPYVCRECGKGFGRNSHLVNHLRVHTGEKPFRCGQCEKRFSDFSTLTQHQRTHTGEKPYTCIECGKSFIQSSHLIRHRRIHTGNKPHKCAGCGKGFRYKTHLAQHQKLHLC", "length": 545 }, "evidence": [ { "id": "E1B8V4", "url": "https://omabrowser.org/oma/group/E1B8V4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B8V4", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8V4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 550, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8V4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8V4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8V4" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 196, "end_pos": 223, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8Z3-1", "uniprot_ac": "E1B8Z3", "uniprot_id": "E1B8Z3_BOVIN", "mass": { "chemical_mass": 123196.0, "monoisotopic_mass": 123196.0 }, "refseq": { "ac": "XP_002697271", "name": "disheveled-associated activator of morphogenesis 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697271" }, "gene_names": [ { "name": "DAAM2", "type": "recommended", "evidence": [ { "id": "E1B8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ] }, { "name": "DAAM2", "type": "synonym", "evidence": [ { "id": "XP_002697271", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697271" } ] } ], "protein_names": [ { "name": "Dishevelled associated activator of morphosis 2", "type": "synonym", "evidence": [ { "id": "E1B8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3/entry#names_and_taxonomy" } ] }, { "name": "disheveled-associated activator of morphogenesis 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002697271", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697271" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DAAM2", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3", "locus": { "chromosome": "23", "start_pos": 13833800, "end_pos": 13699568, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021381", "url": "https://www.ensembl.org/id/ENSBTAG00000021381" } ] } } ], "crossref": [ { "id": "E1B8Z3", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021381", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021381", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783665", "url": "https://www.ncbi.nlm.nih.gov/gene/783665", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783665", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783665", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LS91", "url": "https://www.orthodb.org/?gene=A0A3Q1LS91", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8Z3", "url": "https://www.orthodb.org/?gene=E1B8Z3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45725", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45725", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45725:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45725:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06371", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06371", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697271", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697271", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS91", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Z3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPRKRSRHGLGFLCCFGGSDLPEINLRDNHPLQYMEFSSPIPNPEELNIRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDQAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHAELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSEISTGPVSSPPPPGGPLTLSSSMTNNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCFSMGMPLPPDPFPSSDVPLRKKCVPQPSHPLKSFNWVKLNEERVPGTIWNEIDDMKVFRILDLEDFEKMFSAYQRHQKELGSTEDIHLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELIRSKRLARMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQKRQVRDPNDKFVPVMSDFITVSSFSFSELEDQLNEARAKFSKALMHFGEQDSKMQPDEFFGIFDAFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVHAGSALEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEATRERAINRLNY", "length": 1067, "header": "tr|E1B8Z3-1|E1B8Z3_BOVIN Isoform 1 of Dishevelled associated activator of morphosis 2 OS=Bos taurus OX=9913 GN=DAAM2 PE=3 SV=4 CANONICAL=E1B8Z3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS91/entry", "sequence": { "sequence": "MAPRKRSRHGLGFLCCFGGSDLPEINLRDNHPLQYMEFSSPIPNPEELNIRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDQAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHAELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSEISTGPVSSPPPPGGPLTLSSSMTNNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCFSMGMPLPPDPFPSSDVPLRKKCVPQPSHPLKSFNWVKLNEERVPGTIWNEIDDMKVFRILDLEDFEKMFSAYQRHQELITNPSQQKELGSTEDIHLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELIRSKRLARMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQKRQVRDPNDKFVPVMSDFITVSSFSFSELEDQLNEARAKFSKALMHFGEQDSKMQPDEFFGIFDAFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVHAGSALEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEATRERAINRLNY", "length": 1076, "header": "tr|A0A3Q1LS91-1|A0A3Q1LS91_BOVIN Computationally mapped isoform of Dishevelled associated activator of morphosis 2 OS=Bos taurus OX=9913 GN=DAAM2 PE=3 SV=2 CANONICAL=E1B8Z3-1" }, "locus": { "chromosome": "23", "start_pos": 13832796, "end_pos": 13779308, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070242.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070242.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057936.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057936.2" } ] } }, { "isoform_ac": "E1B8Z3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3/entry", "sequence": { "sequence": "MAPRKRSRHGLGFLCCFGGSDLPEINLRDNHPLQYMEFSSPIPNPEELNIRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDQAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHAELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSEISTGPVSSPPPPGGPLTLSSSMTNNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCFSMGMPLPPDPFPSSDVPLRKKCVPQPSHPLKSFNWVKLNEERVPGTIWNEIDDMKVFRILDLEDFEKMFSAYQRHQKELGSTEDIHLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELIRSKRLARMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQKRQVRDPNDKFVPVMSDFITVSSFSFSELEDQLNEARAKFSKALMHFGEQDSKMQPDEFFGIFDAFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVHAGSALEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEATRERAINRLNY", "length": 1067, "header": "tr|E1B8Z3-1|E1B8Z3_BOVIN Isoform 1 of Dishevelled associated activator of morphosis 2 OS=Bos taurus OX=9913 GN=DAAM2 PE=3 SV=4 CANONICAL=E1B8Z3-1" }, "locus": { "chromosome": "23", "start_pos": 13832796, "end_pos": 13779308, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036988.7", "url": "https://www.ensembl.org/id/ENSBTAT00000036988.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036835.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036835.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 567, "start_aa": "Thr", "end_pos": 567, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr567", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:783665", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783665", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "dorsal spinal cord development", "id": "GO:0021516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021516", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "podocyte cell migration", "id": "GO:0090521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090521", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "regulation of filopodium assembly", "id": "GO:0051489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051489", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "regulation of actin filament polymerization", "id": "GO:0030833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030833", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "negative regulation of oligodendrocyte differentiation", "id": "GO:0048715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048715", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" }, { "name": "regulation of non-canonical Wnt signaling pathway", "id": "GO:2000050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000050", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 838, "end_pos": 840, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Z3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1067, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Z3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Z3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" }, { "id": "PS51231", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51231" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAD", "eco_id": "ECO_0000259", "start_pos": 1016, "end_pos": 1047, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" }, { "id": "PS51444", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51444" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FH2", "eco_id": "ECO_0000259", "start_pos": 595, "end_pos": 994, "start_aa": "Lys", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Z3" }, { "id": "PS51232", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51232" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GBD/FH3", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 416, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 567 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 186, "end_pos": 188 }, { "start_pos": 838, "end_pos": 840 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B901-1", "uniprot_ac": "E1B901", "uniprot_id": "E1B901_BOVIN", "mass": { "chemical_mass": 28281.0, "monoisotopic_mass": 28281.0 }, "refseq": { "ac": "XP_002695436", "name": "leukocyte-associated immunoglobulin-like receptor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695436" }, "gene_names": [ { "name": "LAIR1", "type": "recommended", "evidence": [ { "id": "E1B901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B901" } ] }, { "name": "LAIR1", "type": "synonym", "evidence": [ { "id": "XP_002695436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695436" } ] } ], "protein_names": [ { "name": "Leukocyte associated immunoglobulin like receptor 1", "type": "synonym", "evidence": [ { "id": "E1B901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B901/entry#names_and_taxonomy" } ] }, { "name": "leukocyte-associated immunoglobulin-like receptor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002695436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695436" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B901", "url": "https://www.uniprot.org/uniprotkb/E1B901" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAIR1", "url": "https://www.uniprot.org/uniprotkb/E1B901", "locus": { "chromosome": "18", "start_pos": 62819075, "end_pos": 62827833, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026080", "url": "https://www.ensembl.org/id/ENSBTAG00000026080" } ] } } ], "crossref": [ { "id": "E1B901", "url": "https://alphafold.ebi.ac.uk/entry/E1B901", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026080", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026080", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615295", "url": "https://www.ncbi.nlm.nih.gov/gene/615295", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615295", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615295", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B901", "url": "https://www.orthodb.org/?gene=E1B901", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11738:SF129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11738:SF129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002695436", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695436", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B901", "url": "https://www.uniprot.org/uniprotkb/E1B901", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B901-1", "url": "https://www.uniprot.org/uniprotkb/E1B901-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGPSTLLSLALCLAQTARTQQGTLPRPSISAEPGSVVPWGRPVSIVCRGPAGVMSFRLEKGNRKDYKDVRVTSRGEQETEARFHITALREDAVGRYHCLYQKESTWSALSEALSLEGTEEAVSALPAAPTGLSTEQVYILIGVSVAFLLCLSLLVLLLLHRQLRRKRGPPRSKDEKQRRQGRLSPAVDVLDGTPGVASVDRFPDVDGEVGAFTPAAGGSQEVTYAQLNHKLLTQRVARAVSPPSTEPLAKSSTYATIARR", "length": 262, "header": "tr|E1B901-1|E1B901_BOVIN Isoform 1 of Leukocyte associated immunoglobulin like receptor 1 OS=Bos taurus OX=9913 GN=LAIR1 PE=4 SV=2 CANONICAL=E1B901-1" }, "isoforms": [ { "isoform_ac": "E1B901-1", "url": "https://www.uniprot.org/uniprotkb/E1B901/entry", "sequence": { "sequence": "MAPGPSTLLSLALCLAQTARTQQGTLPRPSISAEPGSVVPWGRPVSIVCRGPAGVMSFRLEKGNRKDYKDVRVTSRGEQETEARFHITALREDAVGRYHCLYQKESTWSALSEALSLEGTEEAVSALPAAPTGLSTEQVYILIGVSVAFLLCLSLLVLLLLHRQLRRKRGPPRSKDEKQRRQGRLSPAVDVLDGTPGVASVDRFPDVDGEVGAFTPAAGGSQEVTYAQLNHKLLTQRVARAVSPPSTEPLAKSSTYATIARR", "length": 262, "header": "tr|E1B901-1|E1B901_BOVIN Isoform 1 of Leukocyte associated immunoglobulin like receptor 1 OS=Bos taurus OX=9913 GN=LAIR1 PE=4 SV=2 CANONICAL=E1B901-1" }, "locus": { "chromosome": "18", "start_pos": 62827518, "end_pos": 62820079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036984.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036984.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036831.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036831.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615295", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615295", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B901-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 262, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B901-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B901" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B924-1", "uniprot_ac": "E1B924", "uniprot_id": "E1B924_BOVIN", "mass": { "chemical_mass": 35091.0, "monoisotopic_mass": 35091.0 }, "refseq": {}, "gene_names": [ { "name": "OR13P2", "type": "recommended", "evidence": [ { "id": "E1B924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ] }, { "name": "OR13P12", "type": "synonym", "evidence": [ { "id": "E1B924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 13 subfamily P member 12", "type": "synonym", "evidence": [ { "id": "E1B924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B924/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR13P2", "url": "https://www.uniprot.org/uniprotkb/E1B924", "locus": {} } ], "crossref": [ { "id": "E1B924", "url": "https://alphafold.ebi.ac.uk/entry/E1B924", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048444", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048444", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614050", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614050", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B924", "url": "https://www.orthodb.org/?gene=E1B924", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B924-1", "url": "https://www.uniprot.org/uniprotkb/E1B924-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQELNQSTVAEFILMGFASNPRTNPLLFTFFLVFYLLILVSNSLLITLIHQDTRLHTPMYFFISVLSMLDMCYTTTTVPQMLVHILSKKRAISFARCVAQMYLFLLFGTTEYCLFSIMSVDRYVAICHPLRYKVIMSPWVCLLMVGICAAYGVVGGLCFTFFAMRLFYCGPNEIDHYFCEVPAVLKLACADISLNDLVNIITGFNVIVVPLSLIVLVYINIFFTIMKIRSAQGRIKAFSTCASHITVVSMFAIPCSITYLSPGSDSLSNNGKKMALFYNIATAFLNPVIYSLRNKDVKNAFLKLVGRGRAPE", "length": 312, "header": "tr|E1B924-1|E1B924_BOVIN Isoform 1 of Olfactory receptor family 13 subfamily P member 12 OS=Bos taurus OX=9913 GN=OR13P2 PE=3 SV=4 CANONICAL=E1B924-1" }, "isoforms": [ { "isoform_ac": "E1B924-1", "url": "https://www.uniprot.org/uniprotkb/E1B924/entry", "sequence": { "sequence": "MQELNQSTVAEFILMGFASNPRTNPLLFTFFLVFYLLILVSNSLLITLIHQDTRLHTPMYFFISVLSMLDMCYTTTTVPQMLVHILSKKRAISFARCVAQMYLFLLFGTTEYCLFSIMSVDRYVAICHPLRYKVIMSPWVCLLMVGICAAYGVVGGLCFTFFAMRLFYCGPNEIDHYFCEVPAVLKLACADISLNDLVNIITGFNVIVVPLSLIVLVYINIFFTIMKIRSAQGRIKAFSTCASHITVVSMFAIPCSITYLSPGSDSLSNNGKKMALFYNIATAFLNPVIYSLRNKDVKNAFLKLVGRGRAPE", "length": 312, "header": "tr|E1B924-1|E1B924_BOVIN Isoform 1 of Olfactory receptor family 13 subfamily P member 12 OS=Bos taurus OX=9913 GN=OR13P2 PE=3 SV=4 CANONICAL=E1B924-1" }, "locus": { "chromosome": "3", "start_pos": 102969336, "end_pos": 102968401, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032529.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032529.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032460.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032460.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614050", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614050", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1B924", "url": "https://www.uniprot.org/uniprotkb/E1B924" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B924-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B924-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B924" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B924" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B933-1", "uniprot_ac": "E1B933", "uniprot_id": "E1B933_BOVIN", "mass": { "chemical_mass": 193498.0, "monoisotopic_mass": 193498.0 }, "refseq": {}, "gene_names": [ { "name": "LRRIQ1", "type": "recommended", "evidence": [ { "id": "E1B933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B933" } ] } ], "protein_names": [ { "name": "Leucine rich repeats and IQ motif containing 1", "type": "synonym", "evidence": [ { "id": "E1B933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B933/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B933", "url": "https://www.uniprot.org/uniprotkb/E1B933" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRIQ1", "url": "https://www.uniprot.org/uniprotkb/E1B933", "locus": { "chromosome": "5", "start_pos": 14877358, "end_pos": 14673266, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027900", "url": "https://www.ensembl.org/id/ENSBTAG00000027900" } ] } } ], "crossref": [ { "id": "ENSBTAG00000027900", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027900", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KHRYAHE", "url": "https://omabrowser.org/oma/group/KHRYAHE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B933", "url": "https://www.orthodb.org/?gene=E1B933", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46652:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46652:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B933", "url": "https://www.uniprot.org/uniprotkb/E1B933", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B933-1", "url": "https://www.uniprot.org/uniprotkb/E1B933-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEGNDDDDIKLSEEIEAELDRISISSLEKYGFDSDSKSETQSDNSDTDSDELPESVLHCINIIKNKSKTAEELILQDLEDTDVLSCGYGGVSNNHMHLRIELPTECKENPEQLIKMLSEIEKEEFLRSRTHCGSPDLVLESDLCDLPVDEHVLPDDADINFGYREVEERCRQSFEAWQDKQKELEDQEKETLKVERDKEEKQFQEEEEKRHCWMKQFEVEKKKLENIQKQEQDKMNDELHKEEKIWKERFKQHADFIRNLHLQMEEERTKFKDLQEKEKMRLSKLQHNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKKKAQEWKEKEAKIRQIEEKRKRLEEKQRIEEEIEKQMQEGRKRREKEYMGKKNILRQEREQLLKMEKLILREATRKQLIISRALKKGEYNAKHLPIEDTSKNKDVGAKRLGDGKLKMWEDASPWLAEESDKRKNVDRELVLKESVQVQLKESMSSQAILAVFKVEEKKKNLAVQCSEEFVKQKRNYENRDQKNQLENLHLKEDVREQFQSQELQSQVQKEEVLKPSINETMRQETQIILGNNQEIDEVKDNESQKIVDDNQQNKMQKVEKEISGQLGTLYEENNIKEISVISMKQKQVPLKLEKSEHIGENTLLQEEEIDLKSKEAEENPNGSALNSDLVFNTNDAVINVEGKINKQNYIVDAPCEDLGGYNAKNCLVFKEVNSLKSQIQEIPEECHENTAECENIVACSIEPTLLSSIEEKRLAWITSFKPWFEIFKQNQQKKIVKRRRIIKCPVNTMPPLNPLEILRCGPWDTLQQVATITFQDLPGCSLSTLAECPNLQFLSLRRCGLTSLHSLSNCKRLKYIDAQENHIETINCENLENLCIVLLNKNQLTSLHGLDGCTNIQSLELSHNKITRIGGLESLKNLQQLIVDHNQLISTTGLCDTPTLMYLDCSHNHLTEVEGIEQCGLLQILKLQGNYLSELPFLGNHVLLRELHLDDNSISTVETFSSYWLPLLQILTISQNSLTKIAPLFHFVSLEKLDVSNNCLSDLTSAIKWFDACFSLHELSLTGNPLLQEINWRHSLLKILPALRILNGEMLTSCTERHTEGHHQLELEHFLEHCQSQIREFNLLSEKYITGDRNIFTLDVAQNLCYYFKKLMTLSNECRCVHEHGDVSMTRRGESEAQQNHLPPTHSDSKQQNRVLYSSANEYKLNSPDISEKWMDSGSSHSSSTNPSLCEDTKERNQEEIVDQKREDSKTSSFPSKRIPFIETVRTRFLLENCQNTEHHEKIMAAMVIQAYWRGYIVRRQIHFSAKLHPATIGPLTSKPNSCIENQTILKKEKVKNTVNIQEQKEKAAILIQAVWKGFLLRKKLTTALEAIKNEESEEEYEEIDLEDFTFDEAALEKEWLALDSARFPSQTLLLPNQLHWPKFSGILKYDDTSLNLPSHPAQAWLCNEKENVLSSEHTQFNSRSENRTLSRLPEAKTSRKSLLKSEKEEKISEEWGFKDISTAQQMLKRAQKMKSKKLRKKLDPTVRLALFRNNENKVSVIKPPEKAQPQRDGFFEDKEEEFMYKDTTANEKLERSKEYTYQWLHTQVGVLETTGSRNMKCKHFLPELDPDVRNGGRVQLVARLVSREDTDLDLFSMTSGSALSVKTEKKTLAHRHSAGSSSKLWFPSELISKSQMN", "length": 1667, "header": "tr|E1B933-1|E1B933_BOVIN Isoform 1 of Leucine rich repeats and IQ motif containing 1 OS=Bos taurus OX=9913 GN=LRRIQ1 PE=4 SV=3 CANONICAL=E1B933-1" }, "isoforms": [ { "isoform_ac": "E1B933-1", "url": "https://www.uniprot.org/uniprotkb/E1B933/entry", "sequence": { "sequence": "MMEGNDDDDIKLSEEIEAELDRISISSLEKYGFDSDSKSETQSDNSDTDSDELPESVLHCINIIKNKSKTAEELILQDLEDTDVLSCGYGGVSNNHMHLRIELPTECKENPEQLIKMLSEIEKEEFLRSRTHCGSPDLVLESDLCDLPVDEHVLPDDADINFGYREVEERCRQSFEAWQDKQKELEDQEKETLKVERDKEEKQFQEEEEKRHCWMKQFEVEKKKLENIQKQEQDKMNDELHKEEKIWKERFKQHADFIRNLHLQMEEERTKFKDLQEKEKMRLSKLQHNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKKKAQEWKEKEAKIRQIEEKRKRLEEKQRIEEEIEKQMQEGRKRREKEYMGKKNILRQEREQLLKMEKLILREATRKQLIISRALKKGEYNAKHLPIEDTSKNKDVGAKRLGDGKLKMWEDASPWLAEESDKRKNVDRELVLKESVQVQLKESMSSQAILAVFKVEEKKKNLAVQCSEEFVKQKRNYENRDQKNQLENLHLKEDVREQFQSQELQSQVQKEEVLKPSINETMRQETQIILGNNQEIDEVKDNESQKIVDDNQQNKMQKVEKEISGQLGTLYEENNIKEISVISMKQKQVPLKLEKSEHIGENTLLQEEEIDLKSKEAEENPNGSALNSDLVFNTNDAVINVEGKINKQNYIVDAPCEDLGGYNAKNCLVFKEVNSLKSQIQEIPEECHENTAECENIVACSIEPTLLSSIEEKRLAWITSFKPWFEIFKQNQQKKIVKRRRIIKCPVNTMPPLNPLEILRCGPWDTLQQVATITFQDLPGCSLSTLAECPNLQFLSLRRCGLTSLHSLSNCKRLKYIDAQENHIETINCENLENLCIVLLNKNQLTSLHGLDGCTNIQSLELSHNKITRIGGLESLKNLQQLIVDHNQLISTTGLCDTPTLMYLDCSHNHLTEVEGIEQCGLLQILKLQGNYLSELPFLGNHVLLRELHLDDNSISTVETFSSYWLPLLQILTISQNSLTKIAPLFHFVSLEKLDVSNNCLSDLTSAIKWFDACFSLHELSLTGNPLLQEINWRHSLLKILPALRILNGEMLTSCTERHTEGHHQLELEHFLEHCQSQIREFNLLSEKYITGDRNIFTLDVAQNLCYYFKKLMTLSNECRCVHEHGDVSMTRRGESEAQQNHLPPTHSDSKQQNRVLYSSANEYKLNSPDISEKWMDSGSSHSSSTNPSLCEDTKERNQEEIVDQKREDSKTSSFPSKRIPFIETVRTRFLLENCQNTEHHEKIMAAMVIQAYWRGYIVRRQIHFSAKLHPATIGPLTSKPNSCIENQTILKKEKVKNTVNIQEQKEKAAILIQAVWKGFLLRKKLTTALEAIKNEESEEEYEEIDLEDFTFDEAALEKEWLALDSARFPSQTLLLPNQLHWPKFSGILKYDDTSLNLPSHPAQAWLCNEKENVLSSEHTQFNSRSENRTLSRLPEAKTSRKSLLKSEKEEKISEEWGFKDISTAQQMLKRAQKMKSKKLRKKLDPTVRLALFRNNENKVSVIKPPEKAQPQRDGFFEDKEEEFMYKDTTANEKLERSKEYTYQWLHTQVGVLETTGSRNMKCKHFLPELDPDVRNGGRVQLVARLVSREDTDLDLFSMTSGSALSVKTEKKTLAHRHSAGSSSKLWFPSELISKSQMN", "length": 1667, "header": "tr|E1B933-1|E1B933_BOVIN Isoform 1 of Leucine rich repeats and IQ motif containing 1 OS=Bos taurus OX=9913 GN=LRRIQ1 PE=4 SV=3 CANONICAL=E1B933-1" }, "locus": { "chromosome": "5", "start_pos": 14877355, "end_pos": 14676151, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040242.4", "url": "https://www.ensembl.org/id/ENSBTAT00000040242.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040019.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040019.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZJI9-1", "protein_name": "Leucine-rich repeats and IQ motif containing 1", "gene_name": "Lrriq1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDSDDSDAKLQEEIEAELDKISISSLENDEVENDSESETQSDDSDTDVLELPESVLHYFSVIKNKSKTAEELILQDLEDTDVFSCSYGAVSDSHMHLRTGSASPESKANSEQLMKILSVIDKEEFMRSLAPSAKRVSVPEPITLDISMDEYVLPDEADLSFGYFEVEERCRKSFEAWQDKQQELEVKDKAILEAQSDREKQSFQEEDEKRQCWIRQFEVEKKKLENLHKQNQDKMNDELHKEEKIWKEKYRQHEERIRNLHLQMEEERTRLRELREKEKARLFKLQHDAAVKIQANYRAWVTYRKYSPIIREQIEKKKRKAQELKEKEAKIRQKEEERRRRIEEEQRIKEERKKKMLEERRRREKEYEEKKSILRQEREEQKSKEKRLREHAHSPLIITCALKKGECHGKQQAIVQMSKSKGSIDKESVGSDSKKQEDTCLVHQLNKRENMHKQIALKESTGIKLKPSQDILAELKLNEKIESLPKLKMNENFSNNQCSGSEQSADQEINSENRDLKSDLENSDLTENVNEQCPGQELNSETQMEGWVEHAPKENVGQETQKLFGFREEMSEEDSNEAPEIIEENHERMTEEIEIKEMTEQDGSSCEENNSSPISIQKNLPPLIPDNPEPVERSVTLAEDEETDLKSERIEEIPEGVLACDASTIKSNASVLTEGKADLQDSFSGKLAPSEEAGSHSACYLLVTDEGEDSPKSEIKETLEEGKQTESEGVGVLACSSSQITVLSSIEEKRLAWVRSFKPWTEIFEQNQLKKIVKKRRLVKCSPNTMPALDPSAILQLGPWKTLQQVTAITFQDLPSCSLSILAECSNLQLLSLQRCGLTSLQGLSHCTNLKYIDAQENHIETISCENLENLSVVLLNKNLLTSIHGFDGCTNIQILELSYNKITRISGLESLKYLQQLIVDHNQLISTKGLCEVPTIVYLDCSHNHLTDVDGIGNCGLLQIVKLQGNYLREPPSLRNHVLLRELHLDDNSISSVEGLSSCWLPLLQILSISQNSLATIVPLFHFVSLEKLDVSNNCLSDLTNVMCWFNACYSLGELCLIGNPVLQEVNWRHSILQALPALRVLNGDMLNSSSNVHIEEYYHQDLRYFLALCQYQLQEFNLLFEKSITQRGDILNMRAADRLSQYYKDLMRLSNECRLAHEQWDVNITKRSAVETKKDHPAFPNSDSTLHNRTFHPQANDCKAHSPAISTILLDTASKPSTSNCEELKGRDQEKLMEQKSKHSSISSLSTMKASIIEMKMADSPMSTHHSDEKCEPSKAAMIIQAQWRSYIARRQIDYSEKPCPTTASEPLCNSFINDQMTSNEEGRKPIMNIQEQREKAALCIQAVWKGFILRKKLVTAIEAIKDEESGEEYEEIDLEDFEFDEDALEKDWPALDSTSFPSQTLPLSKQLPWPKNTRTLRHDETSPPVPAHPAQAWLCNERENLLSSEHTQFSSSRSESGTLSWTPESKSSRKSLLQSEKEEKISEEWGFKDISTAQQMLKRAKKMKSRKLRKKLEPSVRLALFKKNKNKLSVTKSSKKSQLRRDNYFADEEEEAASKATAAKEKLERSKEYTYQWLHTQVGFPEATSSRNVKCNHFLPELDPDVLNGGRVQLVARLVSREDTDLDLFSMTSASTLSVNKEKKSQTHRYSTGSSSGSNKGIIAPMITHTRPSIKERISFRDNPVQLSGGWGSGKRKVKSST", "length": 1702 }, "evidence": [ { "id": "E1B933", "url": "https://omabrowser.org/oma/group/E1B933/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YC81-1", "protein_name": "Leucine rich repeats and IQ motif containing 1", "gene_name": "LRRIQ1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESRMSEDTEGIEKEIESELSRISVSSFEADGPDTEVPEESVSDTESISDDLPESVLSYLNFIKNRNQDAEKVILQDLDDEETTSNIHEVVPCYALDNLAELSSECNEDPEQFKKRLLFEIENEDLKVPTTPSCNSQSSSEVVTDDLFLTADIEMNMSLTYHEVEEKCRQEFQQWEKRQSEIEDDKRKKWKAEREAQEKQNEEEHARRVQHLEKFEAERMELELLHKKQQALMEDELQKEKKAWRDKMMQHEELIMKLQLQMEQEKRAFEEQEAKECKHLTEQRNTAAVKIQARFRAYLVHKEYAPILKQWKDEIKKKKKIQEEIEREMKVREEKMRRRMEERMQNKKEEKKRQEELERQKYLEQVGRRKEYEKKKASLRLEREKQLKIREEQRKLREKIDKAMITENGESNKENIKENKLTENKDVIRDEKKELNKQVEEQEEQTDIMGETNSGMISTERKLTPTLTVLVSEKEDSSRVNNENICINLITYVEENYSQTKELNKEASIIHTLKDESVDFGANYRVESKSNDTCSSQSNAQSNADDQDQFSQSETIEKTVFPMEDANEEVIKNWDTVQEVSKCSNSLILPNDIEKKRTNWMTTCESWSKVYEENQRKIPNIKKRSRKTSVSKMPPLSIQKIIHSGPWSTLQQITTLTLEDLPACSLSTLSQCSNLQVLTLRRCGLVALEGLSSCKDLKYINVEENNIQVIDCENLENLCILILNKNHLSSISGLDGCINLQNLELSYNRITRIGGLESLKNLQQLTVDHNQLISTKGLCEVPTLIHLDCSFNHLTQVEGIESCGLLQILKLHSNNLQEFPRLENHVLLRELYLDDNSISSVRMLSLYWLPLLQILLLSHNSLTELVPLNSFVSLEKLDIKNNCLSDLKSVIACLSGCINLRELSLTGNPLLQERNWRPSLCKILSRLQFLDGENVHYNTLPTTERIEASESRTFLELCQVQIEENVLLKKKVVEEGIAASMDAVQRQCWYFNQLMKLSIKHRCAHEYGELSTTDRDRPEALQNHLKQASTGCLQENNLFIMGVTENKQVLLDPSERWITTGRFQSTFFNSSISVHQKENKEDHRMKQKTTESCINCNGESNSNKNISAQLTLQQSVVESNMGRDSENNTERLRMAASVIQSHWRKYRSRRKTDCTKTRNDHFGEASRQKHEAATVIQASWKGFLLRRKLTSALAAVKSDEVDDNYEEINVDDFVSHEAAIGNEWLTPDSTHFPSKTLLISNQLHWTKYAGPSDTSKHSDNLQLPPQAPWQCLDRPHSTENTRYHRSSEKGTMSQNSDLKEKKKFSSRSDKEEKISEEWGFKDISTAQLMLKRAHKMKPRQYSNKSTDPAVRLALFKKNENKHLCVKPPKIQSVNAGYFEGEKEEFSQLDTSLDEKLQRRKDFTYQWLYTQHSDYETSSSKNMKGCCFLPELNHVSCNSGQVQPVASPVSREDTELDLVSLASGSALTVNREKNKQPHRHSARSSKKNVSTPEKSHFGPSCRERISFRDHPLQFSGGWGTGKKRQKVKNIS", "length": 1530 }, "evidence": [ { "id": "E1B933", "url": "https://omabrowser.org/oma/group/E1B933/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q0P5X1-1", "protein_name": "Leucine-rich repeat- and IQ domain-containing protein 1", "gene_name": "Lrriq1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDSDDSEAKLREEIEAELDKISISSLENDEVENDSVSDTQSDSSDTDLLELPESVLHYINVIKNKSKTAEELILQDVEDTDIFSDYKKGCNHGTVTDSHMHLRTGSLPESKANAEQLMKILSVIEKEEFMRSLAPSARCVSVREIITPDTPMDEYILPDEADLSFGYFEVEERCRKSFEAWQDKQQELEEKDKETLEAQNEREKRTFQEEDEKRQCWMRQFEVEKKHLEDLQKQDQDKMNDELHKEEKIWKEKYRQHEEHIRNLHLKMEEERTRLSELQEKEKARLFKLRYDAAVKIQATYRASVTYRKYSPIIKEQMEKKRRRAQELKEKEAKIRQKEEEKRRRLEEEQRVEEEKKKKMLEERRRREREYEEKKSILRQEREEQRSKEVIRLREHAHSPLIITCALKKGDCHGKQQAIAHVPKGKGTIAKESVDSNSKKQEDACLAQQLNKRENTHVQQLAMKKSTGIKLKPNQAILVELKMNEKNESLPKLKINENLSKNQCSEQPSDQEFNAENVDQKNELENSNLKESVNEQYPWQGLESDTQTEEHVEHVREEKVGQETEKLFGFNQEVSAEDSKQAQGVMEETREGLAEEIEIKEMTQQGGPSDENNSSPISMQKSLPSLTPDNPEPVERSVTLEEDQETDLKSERIEEIPEEGVLSCDAAVINADASVHTEGEADLQDSASGKLAPSEEAGSHSANNLLATEEVEDSPKSEIQEALEKGQQTKAEADGVLTCSVSQLTVLSSVEERRLAWVKTFKPWAEIFEQNQHKKIVKKRRLVKCPPNTMPPLDPSAILQYGPWKSLKQVPVITFQGLPGCSLSTLAECSNLQILSLRRCGLTSLQGLSHCTRLKYIDAQENHIEAISCENLENLSVVLLNNNLLTSIHGFDGCTNLQSLELSHNKITRISGLESLKYLQELTVDHNQLISTKGLCEAPTIVYLDCSHNHLTGIDGIGNCGLLQIIKLQGNYLREPPSLRNHVLLRELHLDDNSISSVEGLSSCWLPLLQYLSISQNSLATIVPLFHLVSLEKLDVSNNCLSDLTNVMCWFNACYSLRELCLTGNPVLQEINWRDSILKTLPALRVLNGDMLNSYANDRIEEHYHQDLRCLLALCQYQLQEFNLLPEKYITQKRDILTLHAVDRLSQYYKDLMKLSHECRRAHEQGDVNTTERSAAETNKNHPDFSNTDSALQNKTLHAQTNSCEADSPATSPNPLDTVFRPSTSHCEELRGRNQEKLMAHKSEQSRISSRSNSRASFIEMKMADSPMSNHHNAERSSPTKAAMVIQAQWRSYIAHRQINCSAEMHPTTTEPLQDPLINNQTTSNEERRKTNMDIQEQREKAALHIQAVWKGFILRKKLATARKAIKDEESGEEYEEIDLEDFEFDEDALEKDWPALDSTGFPSQTLPLSNQLPWPKNSRTLRHDETSPTIPVRPAQAWLCNEKENVMSSEYTQLSSRSESGILSWTPDSKTSRKNLLQSEKEEKISEEWGFKDISTAQQMLKRAKKMKSKKLRKKLEPSVRLALFKKAKNKVSVTKSSKKTQLRRDNYFEAHISSQDEEEEAVSKATAAKEKLERSQEYTYQWLHTQVGFPEATSSRNLKCNHFLPELDPDVLNGGRVQLVARLVSREDTDLDLFSMTSASALSVNKDKKSQTHRYSTGSSSKLWFPSELI", "length": 1673 }, "evidence": [ { "id": "E1B933", "url": "https://omabrowser.org/oma/group/E1B933/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96JM4-4", "protein_name": "Leucine-rich repeat- and IQ domain-containing protein 1", "gene_name": "LRRIQ1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKIMAAVVIQSYWRGYLMRRQTHFSTRLHTAATEGLPNSSIKNQTILKKGKRENIVNIRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDLEDFIFDEAALEEEWLALDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQAWLCNDKENLSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQQMLKRAQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPKMVQPRRDGYFEGIEEDPIHKDTTANEKLERNREYTYQWLHTQVGVHETTSSRNMKCNHFLPELDPDVLNGGRVQLVARLVSREDTDLDLFSMTNGSALSVNREKKNQAHRHSAGSSSKLWFPSKLI", "length": 1722 }, "evidence": [ { "id": "E1B933", "url": "https://omabrowser.org/oma/group/E1B933/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "E1B933", "url": "https://www.uniprot.org/uniprotkb/E1B933" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1315, "end_pos": 1317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1456, "end_pos": 1458, "annotation": "n_glycosylation_sequon" }, { "start_pos": 547, "end_pos": 549, "annotation": "n_glycosylation_sequon" }, { "start_pos": 570, "end_pos": 572, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1315, "end_pos": 1317 }, { "start_pos": 1456, "end_pos": 1458 }, { "start_pos": 547, "end_pos": 549 }, { "start_pos": 570, "end_pos": 572 }, { "start_pos": 650, "end_pos": 652 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B964-1", "uniprot_ac": "E1B964", "uniprot_id": "E1B964_BOVIN", "mass": { "chemical_mass": 68087.0, "monoisotopic_mass": 68087.0 }, "refseq": {}, "gene_names": [ { "name": "LONRF1", "type": "recommended", "evidence": [ { "id": "E1B964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B964" } ] } ], "protein_names": [ { "name": "LON peptidase N-terminal domain and RING finger protein 1", "type": "recommended", "evidence": [ { "id": "E1B964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B964/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B964", "url": "https://www.uniprot.org/uniprotkb/E1B964" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LONRF1", "url": "https://www.uniprot.org/uniprotkb/E1B964", "locus": { "chromosome": "27", "start_pos": 24281633, "end_pos": 24235825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020084", "url": "https://www.ensembl.org/id/ENSBTAG00000020084" } ] } } ], "crossref": [ { "id": "E1B964", "url": "https://alphafold.ebi.ac.uk/entry/E1B964", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020084", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020084", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16514", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16514", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23327", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23327", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23327:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23327:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B964", "url": "https://www.uniprot.org/uniprotkb/E1B964", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B964-1", "url": "https://www.uniprot.org/uniprotkb/E1B964-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRGPPRGRPRPPPSPPPASGPASFSTTWPKSGSRASGSEPGRPAGSGSCCYQGRYREALAAACEELRAEPSDLTLKIYRAESYAGLQEFKAAIEDLNAVLFQLPNWPEVYFRKGKVLHDAGFLGDALQLFLQCLALDEDFAPAKLEVEKILCDLLSPENLKEGLKDSSWSSLPCIKNKPFSFPSVMEESHSASELSPEQNEEIAEVTSEPVKGSLNRARSAQAINSTDMPAREDCLKRVSSEPSLCIQGKGVLLKRKLSLLDQDVIVNEDGRNKLKRQGEIPTEVCTFSLTYGDVPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHTPYCPLCKESLKEYLADRRYCVTQLLEDLIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDIKVENEDEIENLRQLHDLVYSQACSWFQNLRDRFRSQILQHFGSMPGREENLQAIPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQHILTYFSRDQSK", "length": 602, "header": "tr|E1B964-1|E1B964_BOVIN Isoform 1 of LON peptidase N-terminal domain and RING finger protein 1 OS=Bos taurus OX=9913 GN=LONRF1 PE=4 SV=5 CANONICAL=E1B964-1" }, "isoforms": [ { "isoform_ac": "E1B964-1", "url": "https://www.uniprot.org/uniprotkb/E1B964/entry", "sequence": { "sequence": "MPRGPPRGRPRPPPSPPPASGPASFSTTWPKSGSRASGSEPGRPAGSGSCCYQGRYREALAAACEELRAEPSDLTLKIYRAESYAGLQEFKAAIEDLNAVLFQLPNWPEVYFRKGKVLHDAGFLGDALQLFLQCLALDEDFAPAKLEVEKILCDLLSPENLKEGLKDSSWSSLPCIKNKPFSFPSVMEESHSASELSPEQNEEIAEVTSEPVKGSLNRARSAQAINSTDMPAREDCLKRVSSEPSLCIQGKGVLLKRKLSLLDQDVIVNEDGRNKLKRQGEIPTEVCTFSLTYGDVPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHTPYCPLCKESLKEYLADRRYCVTQLLEDLIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDIKVENEDEIENLRQLHDLVYSQACSWFQNLRDRFRSQILQHFGSMPGREENLQAIPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQHILTYFSRDQSK", "length": 602, "header": "tr|E1B964-1|E1B964_BOVIN Isoform 1 of LON peptidase N-terminal domain and RING finger protein 1 OS=Bos taurus OX=9913 GN=LONRF1 PE=4 SV=5 CANONICAL=E1B964-1" }, "locus": { "chromosome": "27", "start_pos": 24280629, "end_pos": 24236339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012816.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012816.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012816.8", "url": "https://www.ensembl.org/id/ENSBTAP00000012816.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B964", "url": "https://www.uniprot.org/uniprotkb/E1B964" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B964", "url": "https://www.uniprot.org/uniprotkb/E1B964" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1B964", "url": "https://www.uniprot.org/uniprotkb/E1B964" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B964-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 602, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B964-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B964" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B964" }, { "id": "PS51787", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51787" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lon N-terminal", "eco_id": "ECO_0000259", "start_pos": 387, "end_pos": 597, "start_aa": "Thr", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B964" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 308, "end_pos": 346, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 226, "end_pos": 228 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B972-1", "uniprot_ac": "E1B972", "uniprot_id": "E1B972_BOVIN", "mass": { "chemical_mass": 22531.0, "monoisotopic_mass": 22531.0 }, "refseq": {}, "gene_names": [ { "name": "CD70", "type": "recommended", "evidence": [ { "id": "E1B972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ] } ], "protein_names": [ { "name": "CD70 antigen", "type": "recommended", "evidence": [ { "id": "E1B972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B972/entry#names_and_taxonomy" } ] }, { "name": "CD27 ligand", "type": "synonym", "evidence": [ { "id": "E1B972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B972/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells.", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972#function" }, { "database": "UniProtKB", "id": "ARBA00056142", "url": "https://www.uniprot.org/uniprotkb/ARBA00056142#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD70", "url": "https://www.uniprot.org/uniprotkb/E1B972", "locus": { "chromosome": "7", "start_pos": 17908730, "end_pos": 17903774, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009752", "url": "https://www.ensembl.org/id/ENSBTAG00000009752" } ] } } ], "crossref": [ { "id": "E1B972", "url": "https://alphafold.ebi.ac.uk/entry/E1B972", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522074", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522074", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGIQWVH", "url": "https://omabrowser.org/oma/group/FGIQWVH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B972", "url": "https://www.orthodb.org/?gene=E1B972", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15152", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15152", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15152:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15152:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B972-1", "url": "https://www.uniprot.org/uniprotkb/E1B972-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCSWRTMMAPEEAASCQVPRWPWASILRVTISVLLSTGTCYLVCNLCFSQQQQLDSTRWDLAELQLNHTGSRQDPRLPWQGSPALGRSFLHGPKLDDNGQLQIQRDGIYRLHIQVTLANCSSSTWTAEPQRATLTVAICSPAAHSISLLRLSFHRGGCWVASQRLTFLARGDILCTNLTLPLLPSRNADETFFGIQWVHP", "length": 201, "header": "tr|E1B972-1|E1B972_BOVIN Isoform 1 of CD70 antigen OS=Bos taurus OX=9913 GN=CD70 PE=3 SV=3 CANONICAL=E1B972-1" }, "isoforms": [ { "isoform_ac": "E1B972-1", "url": "https://www.uniprot.org/uniprotkb/E1B972/entry", "sequence": { "sequence": "MKCSWRTMMAPEEAASCQVPRWPWASILRVTISVLLSTGTCYLVCNLCFSQQQQLDSTRWDLAELQLNHTGSRQDPRLPWQGSPALGRSFLHGPKLDDNGQLQIQRDGIYRLHIQVTLANCSSSTWTAEPQRATLTVAICSPAAHSISLLRLSFHRGGCWVASQRLTFLARGDILCTNLTLPLLPSRNADETFFGIQWVHP", "length": 201, "header": "tr|E1B972-1|E1B972_BOVIN Isoform 1 of CD70 antigen OS=Bos taurus OX=9913 GN=CD70 PE=3 SV=3 CANONICAL=E1B972-1" }, "locus": { "chromosome": "7", "start_pos": 17908684, "end_pos": 17904036, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012860.5", "url": "https://www.ensembl.org/id/ENSBTAT00000012860.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012860.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012860.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522074", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522074", "resource": "KEGG Pathway" }, { "id": "R-BTA-5669034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "resource": "Reactome", "description": "TNFs bind their physiological receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "M0R613-1", "protein_name": "CD70 antigen", "gene_name": "Cd70", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEEGRPYPWVRWSWSAFQRLLPWLLMVIIAICWWLLCGGHLSKPQHVLLEPPELHVAELQLNLTDPQKDLTLRWGAGPALGRSFTHGPGLEKGNLRIHQDGIYRLHIQVTLANCSSSGSALQHRASLVVGICSPAVHSISLLRRRFGQDCTVSLQRLTPLARGDVLCSNLTQPLLPSRNADETFFGVQRVTPA", "length": 194 }, "evidence": [ { "id": "E1B972", "url": "https://omabrowser.org/oma/group/E1B972/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O55237-1", "protein_name": "CD70 antigen", "gene_name": "Cd70", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPEEGRPCPWVRWSGTAFQRQWPWLLLVVFITVFCCWFHCSGLLSKQQQRLLEHPEPHTAELQLNLTVPRKDPTLRWGAGPALGRSFTHGPELEEGHLRIHQDGLYRLHIQVTLANCSSPGSTLQHRATLAVGICSPAAHGISLLRGRFGQDCTVALQRLTYLVHGDVLCTNLTLPLLPSRNADETFFGVQWICP", "length": 195 }, "evidence": [ { "id": "E1B972", "url": "https://omabrowser.org/oma/group/E1B972/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P32970-1", "protein_name": "CD70 antigen", "gene_name": "CD70", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP", "length": 193 }, "evidence": [ { "id": "E1B972", "url": "https://omabrowser.org/oma/group/E1B972/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3ZDR4-1", "protein_name": "CD70 antigen", "gene_name": "CD70", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEEGSGCNVPRLPWASILRAALLLLLIGMVIYCFLCGQRFTQQQLDSTGWDLAELLLNHTESRQDPRLRWQGSPALGRSFVHGPELDNGQLRIQRTGIYRLHIQVTLTNCSSSTWTVMPRQATLTLGICSPTTHSISLLRLNFHHTCRVASQRLTPLAKGDVLCTNLTLPLLPSRNADETFFGVQLVRP", "length": 190 }, "evidence": [ { "id": "E1B972", "url": "https://omabrowser.org/oma/group/E1B972/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "B cell proliferation", "id": "GO:0042100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042100", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "T cell mediated immunity", "id": "GO:0002456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002456", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "T cell proliferation", "id": "GO:0042098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042098", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "B cell mediated immunity", "id": "GO:0019724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019724", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "adaptive immune memory response involving T cells and B cells", "id": "GO:0090717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090717", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "CD27 signaling pathway", "id": "GO:0160162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160162", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "E1B972", "url": "https://www.uniprot.org/uniprotkb/E1B972" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B972" }, { "id": "PS50049", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50049" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THD", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 199, "start_aa": "Asp", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 178, "end_pos": 180 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B978-1", "uniprot_ac": "E1B978", "uniprot_id": "E1B978_BOVIN", "mass": { "chemical_mass": 60903.0, "monoisotopic_mass": 60903.0 }, "refseq": {}, "gene_names": [ { "name": "LRIT2", "type": "recommended", "evidence": [ { "id": "E1B978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B978" } ] } ], "protein_names": [ { "name": "Leucine rich repeat, Ig-like and transmembrane domains 2", "type": "synonym", "evidence": [ { "id": "E1B978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B978/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B978", "url": "https://www.uniprot.org/uniprotkb/E1B978" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRIT2", "url": "https://www.uniprot.org/uniprotkb/E1B978", "locus": { "chromosome": "28", "start_pos": 39190307, "end_pos": 39195767, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023987", "url": "https://www.ensembl.org/id/ENSBTAG00000023987" } ] } } ], "crossref": [ { "id": "E1B978", "url": "https://alphafold.ebi.ac.uk/entry/E1B978", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023987", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023987", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B978", "url": "https://www.orthodb.org/?gene=E1B978", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B978", "url": "https://www.uniprot.org/uniprotkb/E1B978", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B978-1", "url": "https://www.uniprot.org/uniprotkb/E1B978-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVPHYFLLVLVFLDSHVAQPSCLPGCACSEESFGRTLKCVSISLGEIPRNLSEEFKQVRIENSPVFELPRGFFINMHTLEYLWLNFDNVTVIHPGALEHLSELKELRLEGNKLRSVPWTAFRATPLLRILDLKHNRIDALPELALQFLVNLTYLDLSSNRLTVVSKNVFLNWPAYQKHRQSGHEAEMLSSMVLALHDNPWLCDCRLRGLVQFIKSISLPVILVNPYLMCRGPLFKAGQLFHETELSVCTKPQISTPSANVSVQVGQNVTLRCLAQASPSPTIAWTYPLSTWREFDVLTSFTAEDATLSELVIPAAHLVDRGNYTCMASNPIGMSTVVISLRVQPAQALLAPRSVFSPSESSAYVDLRVVKQTVHGILLEWFAAADTPETWFTLYIASDEAFRKKVVHVGPGINTYTVDDLLPGTKYEICLSLGGQPPRQGRCVVFVTGRDDGGLEGRERLLHTTVILCAVLLAVPVGAYAWAAQAPCSCRGWGQRWCLHRRKAPRCPQAVPEHRDDPYRDHTAVCEDGLGPGGADPEGDEQRAGEGD", "length": 549, "header": "tr|E1B978-1|E1B978_BOVIN Isoform 1 of Leucine rich repeat, Ig-like and transmembrane domains 2 OS=Bos taurus OX=9913 GN=LRIT2 PE=4 SV=4 CANONICAL=E1B978-1" }, "isoforms": [ { "isoform_ac": "E1B978-1", "url": "https://www.uniprot.org/uniprotkb/E1B978/entry", "sequence": { "sequence": "MASVPHYFLLVLVFLDSHVAQPSCLPGCACSEESFGRTLKCVSISLGEIPRNLSEEFKQVRIENSPVFELPRGFFINMHTLEYLWLNFDNVTVIHPGALEHLSELKELRLEGNKLRSVPWTAFRATPLLRILDLKHNRIDALPELALQFLVNLTYLDLSSNRLTVVSKNVFLNWPAYQKHRQSGHEAEMLSSMVLALHDNPWLCDCRLRGLVQFIKSISLPVILVNPYLMCRGPLFKAGQLFHETELSVCTKPQISTPSANVSVQVGQNVTLRCLAQASPSPTIAWTYPLSTWREFDVLTSFTAEDATLSELVIPAAHLVDRGNYTCMASNPIGMSTVVISLRVQPAQALLAPRSVFSPSESSAYVDLRVVKQTVHGILLEWFAAADTPETWFTLYIASDEAFRKKVVHVGPGINTYTVDDLLPGTKYEICLSLGGQPPRQGRCVVFVTGRDDGGLEGRERLLHTTVILCAVLLAVPVGAYAWAAQAPCSCRGWGQRWCLHRRKAPRCPQAVPEHRDDPYRDHTAVCEDGLGPGGADPEGDEQRAGEGD", "length": 549, "header": "tr|E1B978-1|E1B978_BOVIN Isoform 1 of Leucine rich repeat, Ig-like and transmembrane domains 2 OS=Bos taurus OX=9913 GN=LRIT2 PE=4 SV=4 CANONICAL=E1B978-1" }, "locus": { "chromosome": "28", "start_pos": 39195767, "end_pos": 39190307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033025.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033025.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032951.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032951.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B978-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 549, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B978-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B978" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B978" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 253, "end_pos": 345, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B979-1", "uniprot_ac": "E1B979", "uniprot_id": "E1B979_BOVIN", "mass": { "chemical_mass": 16657.0, "monoisotopic_mass": 16657.0 }, "refseq": {}, "gene_names": [ { "name": "CYREN", "type": "recommended", "evidence": [ { "id": "E1B979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ] } ], "protein_names": [ { "name": "Transmembrane protein 140", "type": "synonym", "evidence": [ { "id": "E1B979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B979/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYREN", "url": "https://www.uniprot.org/uniprotkb/E1B979", "locus": {} } ], "crossref": [ { "id": "E1B979", "url": "https://alphafold.ebi.ac.uk/entry/E1B979", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001773", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001773", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B979", "url": "https://www.orthodb.org/?gene=E1B979", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14566", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14566", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14566:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14566:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15325", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15325", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B979-1", "url": "https://www.uniprot.org/uniprotkb/E1B979-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDLKSENKKRVLPTWMTAQVAEKRAPQVKTPKRTPATVPAAAARFPAMRTVYCMNEAEVVDVALGILIEDRKQEKPLEPPPLAGADKPERSPASPAPPSPSPRWSRSEDSEEEDRGADGPAPGPAGSDTACSRSLEEDQDELKYVREIFFS", "length": 152, "header": "tr|E1B979-1|E1B979_BOVIN Isoform 1 of Transmembrane protein 140 OS=Bos taurus OX=9913 GN=CYREN PE=4 SV=4 CANONICAL=E1B979-1" }, "isoforms": [ { "isoform_ac": "E1B979-1", "url": "https://www.uniprot.org/uniprotkb/E1B979/entry", "sequence": { "sequence": "MEDLKSENKKRVLPTWMTAQVAEKRAPQVKTPKRTPATVPAAAARFPAMRTVYCMNEAEVVDVALGILIEDRKQEKPLEPPPLAGADKPERSPASPAPPSPSPRWSRSEDSEEEDRGADGPAPGPAGSDTACSRSLEEDQDELKYVREIFFS", "length": 152, "header": "tr|E1B979-1|E1B979_BOVIN Isoform 1 of Transmembrane protein 140 OS=Bos taurus OX=9913 GN=CYREN PE=4 SV=4 CANONICAL=E1B979-1" }, "locus": { "chromosome": "4", "start_pos": 98816046, "end_pos": 98813274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002323.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002323.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002323.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002323.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein localization to site of double-strand break", "id": "GO:1990166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990166", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via nonhomologous end joining", "id": "GO:2001034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001034", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "double-strand break repair via nonhomologous end joining", "id": "GO:0006303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006303", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "immunoglobulin V(D)J recombination", "id": "GO:0033152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033152", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "negative regulation of double-strand break repair via nonhomologous end joining", "id": "GO:2001033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001033", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" }, { "name": "DNA repair complex", "id": "GO:1990391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990391", "evidence": [ { "database": "UniProtKB", "id": "E1B979", "url": "https://www.uniprot.org/uniprotkb/E1B979" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B993-1", "uniprot_ac": "E1B993", "uniprot_id": "E1B993_BOVIN", "mass": { "chemical_mass": 86915.0, "monoisotopic_mass": 86915.0 }, "refseq": { "ac": "XP_002692084", "name": "ankyrin repeat and EF-hand domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692084" }, "gene_names": [ { "name": "ANKEF1", "type": "recommended", "evidence": [ { "id": "E1B993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B993" } ] }, { "name": "ANKEF1", "type": "synonym", "evidence": [ { "id": "XP_002692084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692084" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and EF-hand domain containing 1", "type": "synonym", "evidence": [ { "id": "E1B993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B993/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and EF-hand domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002692084", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692084" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B993", "url": "https://www.uniprot.org/uniprotkb/E1B993" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKEF1", "url": "https://www.uniprot.org/uniprotkb/E1B993", "locus": { "chromosome": "13", "start_pos": 3280466, "end_pos": 3252072, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019726", "url": "https://www.ensembl.org/id/ENSBTAG00000019726" } ] } } ], "crossref": [ { "id": "E1B993", "url": "https://alphafold.ebi.ac.uk/entry/E1B993", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019726", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019726", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "788870", "url": "https://www.ncbi.nlm.nih.gov/gene/788870", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788870", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788870", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ATDNFMW", "url": "https://omabrowser.org/oma/group/ATDNFMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B993", "url": "https://www.orthodb.org/?gene=E1B993", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24127:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24127:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002692084", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692084", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B993", "url": "https://www.uniprot.org/uniprotkb/E1B993", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B993-1", "url": "https://www.uniprot.org/uniprotkb/E1B993-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALADKRLENLQIYKVLQCVRNKDKKQIEKLTRLGYPELINFTDPVNGNSALHLASVSNDIDMVSFLLSLGAHPDVQDKMGCTPTMRAAELGHELSMEILAKAKADMTVVDNEGKGILFYCILPTKRHYRCALIALEHGADVNNCTCEGKPIFLRACEEAHDVKDVCLTFLEKGANPNAINTSTGRTALMEASREGVTELVRGILERGGDVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDMGLIAMNGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLEHKTPRNLAKEGGFKAASKEIRRAEQIANKLARPGVKNPNPHLFLRLHDWSVEHETFLREAFSFVDRGDGTVTKEDFVLTLEERQDFVNSEQLAAIAQLHEKVRGGGVNINEFFKGTRYLSKSYVLGSYGPKKKKKGMAKRARVGKFVFPLPICIIPDHVFPRRSDGGPPYYMIETYKNVTDCNRFNRDHPPEHPIQDDSAWYIDDPGKVFSNINFITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACATGNIDAVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVKSGAVVDALSINNSTPLSRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADSRIIGLIKEKLDNLPKPAENQKPKGKPQPKAKTEGPEIKKEEETLSAIYTVPAIVEDKKMRKDNVVYLNSLITSGYTKKVDITFIPQRIWSPEATTAELIRMRELRRERLTYEVDFDDFMMPFQKHITERAQAVEASFKM", "length": 776, "header": "tr|E1B993-1|E1B993_BOVIN Isoform 1 of Ankyrin repeat and EF-hand domain containing 1 OS=Bos taurus OX=9913 GN=ANKEF1 PE=1 SV=1 CANONICAL=E1B993-1" }, "isoforms": [ { "isoform_ac": "E1B993-1", "url": "https://www.uniprot.org/uniprotkb/E1B993/entry", "sequence": { "sequence": "MALADKRLENLQIYKVLQCVRNKDKKQIEKLTRLGYPELINFTDPVNGNSALHLASVSNDIDMVSFLLSLGAHPDVQDKMGCTPTMRAAELGHELSMEILAKAKADMTVVDNEGKGILFYCILPTKRHYRCALIALEHGADVNNCTCEGKPIFLRACEEAHDVKDVCLTFLEKGANPNAINTSTGRTALMEASREGVTELVRGILERGGDVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDMGLIAMNGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLEHKTPRNLAKEGGFKAASKEIRRAEQIANKLARPGVKNPNPHLFLRLHDWSVEHETFLREAFSFVDRGDGTVTKEDFVLTLEERQDFVNSEQLAAIAQLHEKVRGGGVNINEFFKGTRYLSKSYVLGSYGPKKKKKGMAKRARVGKFVFPLPICIIPDHVFPRRSDGGPPYYMIETYKNVTDCNRFNRDHPPEHPIQDDSAWYIDDPGKVFSNINFITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACATGNIDAVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVKSGAVVDALSINNSTPLSRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADSRIIGLIKEKLDNLPKPAENQKPKGKPQPKAKTEGPEIKKEEETLSAIYTVPAIVEDKKMRKDNVVYLNSLITSGYTKKVDITFIPQRIWSPEATTAELIRMRELRRERLTYEVDFDDFMMPFQKHITERAQAVEASFKM", "length": 776, "header": "tr|E1B993-1|E1B993_BOVIN Isoform 1 of Ankyrin repeat and EF-hand domain containing 1 OS=Bos taurus OX=9913 GN=ANKEF1 PE=1 SV=1 CANONICAL=E1B993-1" }, "locus": { "chromosome": "13", "start_pos": 3279593, "end_pos": 3257091, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026288.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026288.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026288.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026288.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1B993", "url": "https://www.uniprot.org/uniprotkb/E1B993" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:788870", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788870", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I1F9-1", "protein_name": "Ankyrin repeat and EF-hand domain-containing protein 1", "gene_name": "Ankef1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALADKRLENLQIYRVLQCVRNKDKKQIEKLTRLGYPELINFTEPIDGLSALHLASISNDIDMVSFLLGLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGILFYCILPTKRHYRCSLIALDHGADVNNITYEGKPVFLKACEEAHDVKEMCMTFLEKGANPNAINSSTGRTALMEASREGAVELVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYSGDMGLIGMNGNTPLHYAAMGGFADCCKYLAQRGCELKWKNLEHKTPRAVAKDGGFKAASKEIRRAERTAAKLAKPGVKNPNPIWALRLHDWSIEHEAFLREAFTFVDRGDGSVSKDDFVVTLEERQDFATPDQLLQIAQMHEKSRGSGININDFFKGTKYLSKSFVLGSFGPKKKKKSLSRKPKKGKFFLPLPVCTIPENAFPRRPDGGPPYYMIETYQNVSDCSRFNRDHPPDHPIQDDSVWYMDEPGKVFANINFITMAGDLSSLKKAFEAGIPVDMKDSSYKTPLMTACASGNLDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLIKSGAAVDAMSINNSTPLSRAIESCRLDTVKYLLDIGAKFQIENRRGHAAMDVAKAYADYRIIDMIKEKIDSLPKPLDNQKMKPKLPKLKSEGTDIKKEEETLSSVYAVPPITEEKKLSKDNVVYLNSLITSGYTKKVDITFIPRRIWSPEATTAELIRKRELRRERFTYEVDFEDFMMPFQKNIMEKAQALEASLKL", "length": 775 }, "evidence": [ { "id": "E1B993", "url": "https://omabrowser.org/oma/group/E1B993/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Z5B9-1", "protein_name": "Ankyrin repeat and EF-hand domain containing 1", "gene_name": "ANKEF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPVDNRLRNLQIYKLLQCVHQKDKKQIEKLIQNGFPNLINFTEPMDGHSALSLACIKNDIDMCSFLLERGAHPDVQDKMGCTPAMKAAELGHSLVLELLAKIKADMTIVDNEGKGVLFYCILPTRRHYHCTQIALDYGADINNCSTDGKPVFLQACEQAHDIKEICLNFLERGANPNARDPVTGRTAIMEAAREGALEVVRGILERGGDINLFDNERHNAAHFAAKGGFFEILRIISAYNGDLGLIAMNGNTPLHYAAEGGFANCCKFIGQRGCDPTWTNLLAKTPRAVAKEGGFKAAATELHKIEKNFIKQSKPGAKENNPLWALRLYDWSLEHQTALLQAFEAVDQGDGTVAKDDFISVIQKWCSFVDAEQIQTIAEAHEKPDSEGINTEEFFKGFKYLQKSCLITSFGPKRKKGKKGKKRRSKKSVAVPVPICVIPKSACLLREDGFPVYMIEAVQSTADSYHINQDHPSAHPVHDDRAWYTDEPRKMYMNINFLVRAGDILSLQKAFEEGVPVDIKDKYYKTPLMAACTSGNIDVVRYLLEKGADVNATDNFMWTPLHHACYNGHLDIAELMVKAGGAIDAPAIGNATPLMRAVEICRLDIVHFLIDAGADVQTTNSNGKNALDIAKVFADSRIIDLLQNKLDNLPKVTEKKGAEKGTVAKPKMPSAPTPSEVQAVKTEPSHASLPPLEKPRLEKPAQDSVVYLNSLISSGATKKDDIAFKPRKIWTPDAATKELVRKQELLWERSTLGGDSENFESPFKRKVTE", "length": 770 }, "evidence": [ { "id": "E1B993", "url": "https://omabrowser.org/oma/group/E1B993/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A9E7-1", "protein_name": "Ankyrin repeat and EF-hand domain containing 1", "gene_name": "Ankef1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALADKRLENLQIYRVLQCVRNKDKKQIEKLTKLGYPELINFTEPIDGLSALHLASVSNDIDMVSFLLGLGAHPDVQDHMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHFRCSQIALEHGADVNNITYEGKPVFLRACEEAHDVKDMCLTFLEKGANPNAINTSTGRTALMESSREGVLELVRGILERGGEVNTFDNDRHNAAHFAAKGGFFDILKLLFAYSGEMGLIGMDGNTPLHFAAMGGFADCCKYIAQRGCDLKWKNLEHKTPRMVAKDGGFKAASKEIRRAERTAAKLAKPGVKNPNPLWALRLHDWSIEHESSLREAFSFVDRGDGVVSKDDFVLALEERQEFATPEQLLSVAQMHEKSRGGGVNINDFFKGTKYLSKSFVLGSFGPKKKKKGLGKKPRKGKFVLPLPICTIPENAFPRRPDGGPPYYMVETYQNVTDTNRFNRDHPPEHPIQDDSEWYIDDPNRVFANINFITKAGDLASLKKAFEAGIPVDMKDNTYKTPLMTACASGNIDVVKFLLERGANVNATDNFLWTPLHFACHAGQQDIVELLVQSGAVIDASSINNSTPLSRAIESCRLDTVKYLLDNGAKFQTENRKGHAAMDIAKAYADYRIIDMIKEKLDELPKPTDNQKMKSKLPKLKTEGTDVKKEEGTLSSIYTVPAITEEKKIHRDNVVYLNSLITSGFTKKVDITFIPKRIWSPEATTAQLIRKRELRRERFTYEVDFEDFMMPFQKNITEKAQALESMLKN", "length": 775 }, "evidence": [ { "id": "E1B993", "url": "https://omabrowser.org/oma/group/E1B993/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SBK5-1", "protein_name": "Ankyrin repeat and EF-hand domain containing 1", "gene_name": "ANKEF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALADKRLENLQIYKVLQCVRNKDKKQIEKLTRLGYPELINFTDPINGHSALHLASVSNDIDMVSFLLNLGAHPDVQDGMGCTPAMRAAELGHELSMEILAKAKADMTIVDNEGKGILFYCILPTKRHYRCTLIALEHGADVNNCTYEGKPIFLRACEEAHDVKDVCLTLLEKGANPNAINTSTGRTALMEASREGVIELVRGILERGGEVNAFDKDRHHAAHFAAKGGFFDILKLLFAYDGDMGLIAMNGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRALAKEGGFRAASKEIQQAERIANKLARPGAKNPNPQLYLRLHDWSVEHETFLREAFSFVDRGDGTVTKEDFVLALEERQDFVDSEQLAVIAQLHEKVRGGGVNINDFFKGTKYLSKSYVLGSFGLKRKKKGMAKRAKKGKLVLPLPICIIPDHVFPRRSDGGLPYYMIETYQNVTDCNRFNRDHPPEHPIQDDSAWYIDDPGKAFSNINFITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIAELLVKSGAVVDALSINNSTPLSRAIESCSLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRVIGLIKEKMDNLPKPAENQKPKGKPSLKVKTEGPEIKKEEERLSSIYTIPTVVQEKKMHKDNVVYLNSLITSGYTKKVDITFIPRRIWSPEATTAELIRKRELRREKFTYEVDFDEFMMPFQKNITEKAQALEAAFRT", "length": 776 }, "evidence": [ { "id": "E1B993", "url": "https://omabrowser.org/oma/group/E1B993/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D2J7-1", "protein_name": "Ankyrin repeat and EF-hand domain-containing protein 1", "gene_name": "Ankef1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALADKRLENLQIYRVLQCVRNKDKKQIEKLTRLGYPELINFTEPIDGLSALHLASISNDTDMVSFLLKLGAHPDVQDHMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCSLIALEHGADVNNITYEGKPVFLRACEEAHDVKDMCLTFLEKGANPNAINTSTGRTALMESSREGVLEIVRGILERGGEVNAYDNDRHHAAHFAAKGGFFDILKLLFAYNGDMGLIGMDGNTPLHFAAMGGFADCCKYIAQRGCDLKWKNLEHKTPRVVAKDGGFKAASKEIRRAERTAAKLAKTGAKNPNPLWALRLHDWSIEHETSLRNAFKFVDRGDGVVSKDDFVVALEERQEYATSEQLLSVAQMHEKSRGGGVNINEFFKGTKYLSKSYVLGSFGPKKKKRGLGKKPRKGKFVLPLPICTIPENAFPRRPDGGPPYYMIETYQNVSDSHRFNRDHPPEHPIQDDSEWYIDDPSRVFANISFITKAGDLASLKKAIETGIPVDMKDNTYKTPLMIACASGNIDVVKFLIEKGANVNATDNFLWTPLHFACHAGQQDIVELLVKAGASIDATSINNSTPLSRAIESCRLDTVKYLLDMGAKFQIENRKGHAAMDIAKAYADYRIIDMIKEKLDNLPKQADNQKMKGKLPKLKTEGTDVKKEEETLSSIYTVPAITEEKKVHRDSVVYLNSLITSGFTKKVDITFIPKRIWSPEATTAELIRKRELRRERFTYEVDFEDFMMPFQKNITEKAQALEATLKN", "length": 775 }, "evidence": [ { "id": "E1B993", "url": "https://omabrowser.org/oma/group/E1B993/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NU02-1", "protein_name": "Ankyrin repeat and EF-hand domain-containing protein 1", "gene_name": "ANKEF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITFIPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT", "length": 776 }, "evidence": [ { "id": "E1B993", "url": "https://omabrowser.org/oma/group/E1B993/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B993-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 776, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B993-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B993" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 181, "end_pos": 183 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 461, "end_pos": 463 }, { "start_pos": 552, "end_pos": 554 }, { "start_pos": 590, "end_pos": 592 }, { "start_pos": 591, "end_pos": 593 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9A2-1", "uniprot_ac": "E1B9A2", "uniprot_id": "E1B9A2_BOVIN", "mass": { "chemical_mass": 116649.0, "monoisotopic_mass": 116649.0 }, "refseq": { "ac": "XP_015314561", "name": "caspase recruitment domain-containing protein 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314561" }, "gene_names": [ { "name": "CARD6", "type": "recommended", "evidence": [ { "id": "E1B9A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A2" } ] }, { "name": "CARD6", "type": "synonym", "evidence": [ { "id": "XP_015314561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314561" } ] } ], "protein_names": [ { "name": "Caspase recruitment domain family member 6", "type": "synonym", "evidence": [ { "id": "E1B9A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A2/entry#names_and_taxonomy" } ] }, { "name": "caspase recruitment domain-containing protein 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015314561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314561" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9A2", "url": "https://www.uniprot.org/uniprotkb/E1B9A2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CARD6", "url": "https://www.uniprot.org/uniprotkb/E1B9A2", "locus": { "chromosome": "20", "start_pos": 33625018, "end_pos": 33640022, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014374", "url": "https://www.ensembl.org/id/ENSBTAG00000014374" } ] } } ], "crossref": [ { "id": "E1B9A2", "url": "https://alphafold.ebi.ac.uk/entry/E1B9A2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014374", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014374", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01671", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01671", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520291", "url": "https://www.ncbi.nlm.nih.gov/gene/520291", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9A2", "url": "https://www.orthodb.org/?gene=E1B9A2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22797", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22797", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22797:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22797:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015314561", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9A2", "url": "https://www.uniprot.org/uniprotkb/E1B9A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9A2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9A2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGSVPSQIIEKERKKLLEILQQDPDCILDTLTSRKLISEEEYEILENITDPLKKSRKLLILVQKKGEVSCQLFLNCLFNTFSQSATICNLNQVLKHEYIEPPLPIGTSKEDVFLSGEKQPENPEITTSFKEKECMDLETSESFTDKKTSYQETAWSSKENEKEDNTSKFTSPQSVEIVEYEFPATIEYLQDGQRYEDPDDSLYLEQEDYLESVGYSEEANITLEEEAYSDPGGLYDDREDSVYLETTEFSDEEQHYEDPETGMSLEEEEEKSMEERKNVFKDVLSCLNLDTSRKILPDFVKQFSLDRGCTWVPETPSDLAWNFLMKVQALDVTARDSVLRPKVLGEESKGELLTGVENLEIKETETINPLDVLCASLLSSDSSLQREVMSNMYHCRFALPLLLPDAENNRSILMLGAMKDILKEQSTQSSGGPTGDTEKFLTLMKMPVISFVRLGYCSFSKSRILNALLSPAHLKSHKIFLHQDLPVQVLPRQISDGLVEITWCFPDSSSLSESPSFPQKPVAVANLRGDLESFWTQFGFLMEVSSAVFFLTDCLGEKEWDLLMFLGEAAIERCYFVLSPQARESEEAQVFQRVLKLKPSQLLFWEEEEVGQRGGNMEGLQAALQEVMSSSLKCVSVEDMAPLARELGIQVDQDFENIQGIQVSPSENLAGAAEDEGSQRHSQRKNSSESPAKMSETSCQINQNRQNFHLTPVFMPPLRNFHPLPARIGGNFNHVSLKAPWAMGSRFWLQQRPKRFHPLPFQNTRAHSPGKRFGIQYFQPQRFYSGETFMRFSGTPWRHHMGRTFGRPPRPMSQHIPAWPQRPQTIGTLERSGKEDSQVGHLHSLGSWPGGAVGKPGQVSARGTKPTETVRTSMRTKPHIENPHHQAFQAAGATQKPRRTAPQQGAKLKTQGGPSNPSFQMGFHPMSYSMYLPSSQFRPNQHKSPQVKQSQHKPSQPVPFQPKPTQTKPTQHQAPRAESSPSKSTQPKPCQPQSSQSKPFQPKPTQPKSSHTGPSQAKAYCPRPGPKRGGKH", "length": 1034, "header": "tr|E1B9A2-1|E1B9A2_BOVIN Isoform 1 of Caspase recruitment domain family member 6 OS=Bos taurus OX=9913 GN=CARD6 PE=4 SV=2 CANONICAL=E1B9A2-1" }, "isoforms": [ { "isoform_ac": "E1B9A2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9A2/entry", "sequence": { "sequence": "MAAGSVPSQIIEKERKKLLEILQQDPDCILDTLTSRKLISEEEYEILENITDPLKKSRKLLILVQKKGEVSCQLFLNCLFNTFSQSATICNLNQVLKHEYIEPPLPIGTSKEDVFLSGEKQPENPEITTSFKEKECMDLETSESFTDKKTSYQETAWSSKENEKEDNTSKFTSPQSVEIVEYEFPATIEYLQDGQRYEDPDDSLYLEQEDYLESVGYSEEANITLEEEAYSDPGGLYDDREDSVYLETTEFSDEEQHYEDPETGMSLEEEEEKSMEERKNVFKDVLSCLNLDTSRKILPDFVKQFSLDRGCTWVPETPSDLAWNFLMKVQALDVTARDSVLRPKVLGEESKGELLTGVENLEIKETETINPLDVLCASLLSSDSSLQREVMSNMYHCRFALPLLLPDAENNRSILMLGAMKDILKEQSTQSSGGPTGDTEKFLTLMKMPVISFVRLGYCSFSKSRILNALLSPAHLKSHKIFLHQDLPVQVLPRQISDGLVEITWCFPDSSSLSESPSFPQKPVAVANLRGDLESFWTQFGFLMEVSSAVFFLTDCLGEKEWDLLMFLGEAAIERCYFVLSPQARESEEAQVFQRVLKLKPSQLLFWEEEEVGQRGGNMEGLQAALQEVMSSSLKCVSVEDMAPLARELGIQVDQDFENIQGIQVSPSENLAGAAEDEGSQRHSQRKNSSESPAKMSETSCQINQNRQNFHLTPVFMPPLRNFHPLPARIGGNFNHVSLKAPWAMGSRFWLQQRPKRFHPLPFQNTRAHSPGKRFGIQYFQPQRFYSGETFMRFSGTPWRHHMGRTFGRPPRPMSQHIPAWPQRPQTIGTLERSGKEDSQVGHLHSLGSWPGGAVGKPGQVSARGTKPTETVRTSMRTKPHIENPHHQAFQAAGATQKPRRTAPQQGAKLKTQGGPSNPSFQMGFHPMSYSMYLPSSQFRPNQHKSPQVKQSQHKPSQPVPFQPKPTQTKPTQHQAPRAESSPSKSTQPKPCQPQSSQSKPFQPKPTQPKSSHTGPSQAKAYCPRPGPKRGGKH", "length": 1034, "header": "tr|E1B9A2-1|E1B9A2_BOVIN Isoform 1 of Caspase recruitment domain family member 6 OS=Bos taurus OX=9913 GN=CARD6 PE=4 SV=2 CANONICAL=E1B9A2-1" }, "locus": { "chromosome": "20", "start_pos": 33639871, "end_pos": 33625942, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019112.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019112.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019112.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019112.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 436, "start_aa": "Thr", "end_pos": 436, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr436", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9A2", "url": "https://www.uniprot.org/uniprotkb/E1B9A2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "E1B9A2", "url": "https://www.uniprot.org/uniprotkb/E1B9A2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 688, "end_pos": 690, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9A2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1034, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9A2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9A2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A2" }, { "id": "PS50209", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50209" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CARD", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 79, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 436 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 222, "end_pos": 224 }, { "start_pos": 411, "end_pos": 413 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 688, "end_pos": 690 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9A3-1", "uniprot_ac": "E1B9A3", "uniprot_id": "E1B9A3_BOVIN", "mass": { "chemical_mass": 55773.0, "monoisotopic_mass": 55773.0 }, "refseq": { "ac": "NP_001192785", "name": "nucleotidyltransferase MB21D2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192785" }, "gene_names": [ { "name": "MB21D2", "type": "recommended", "evidence": [ { "id": "E1B9A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A3" } ] }, { "name": "MB21D2", "type": "synonym", "evidence": [ { "id": "NP_001192785", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192785" } ] } ], "protein_names": [ { "name": "Nucleotidyltransferase MB21D2", "type": "recommended", "evidence": [ { "id": "E1B9A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A3/entry#names_and_taxonomy" } ] }, { "name": "Mab-21 domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "E1B9A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A3/entry#names_and_taxonomy" } ] }, { "name": "nucleotidyltransferase MB21D2", "type": "synonym", "evidence": [ { "id": "NP_001192785", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192785" } ] } ], "function": [ { "annotation": "Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus.", "evidence": [ { "database": "UniProtKB", "id": "E1B9A3", "url": "https://www.uniprot.org/uniprotkb/E1B9A3#function" }, { "database": "UniProtKB", "id": "ARBA00054069", "url": "https://www.uniprot.org/uniprotkb/ARBA00054069#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9A3", "url": "https://www.uniprot.org/uniprotkb/E1B9A3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MB21D2", "url": "https://www.uniprot.org/uniprotkb/E1B9A3", "locus": { "chromosome": "1", "start_pos": 74610296, "end_pos": 74489003, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005430", "url": "https://www.ensembl.org/id/ENSBTAG00000005430" } ] } } ], "crossref": [ { "id": "E1B9A3", "url": "https://alphafold.ebi.ac.uk/entry/E1B9A3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005430", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005430", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519376", "url": "https://www.ncbi.nlm.nih.gov/gene/519376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519376", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FTRHDQR", "url": "https://omabrowser.org/oma/group/FTRHDQR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9A3", "url": "https://www.orthodb.org/?gene=E1B9A3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192785", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9A3", "url": "https://www.uniprot.org/uniprotkb/E1B9A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9A3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9A3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMAAPTASKAASLGCNNKPAFPELDFRSGARVEELNKLIQEFTKHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISSSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLELQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 491, "header": "tr|E1B9A3-1|E1B9A3_BOVIN Isoform 1 of Nucleotidyltransferase MB21D2 OS=Bos taurus OX=9913 GN=MB21D2 PE=3 SV=2 CANONICAL=E1B9A3-1" }, "isoforms": [ { "isoform_ac": "E1B9A3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9A3/entry", "sequence": { "sequence": "MKMAAPTASKAASLGCNNKPAFPELDFRSGARVEELNKLIQEFTKHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISSSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLELQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 491, "header": "tr|E1B9A3-1|E1B9A3_BOVIN Isoform 1 of Nucleotidyltransferase MB21D2 OS=Bos taurus OX=9913 GN=MB21D2 PE=3 SV=2 CANONICAL=E1B9A3-1" }, "locus": { "chromosome": "1", "start_pos": 74609952, "end_pos": 74489024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007148.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007148.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007148.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007148.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519376", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ACS3-1", "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "Mb21d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKMAAPTASKAASMGCNNKPAFPELDFRSGARVEELNKLIQEFTRHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIADHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISGSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPVSYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLKLQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 491 }, "evidence": [ { "id": "E1B9A3", "url": "https://omabrowser.org/oma/group/E1B9A3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C397-1", "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "MB21D2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKMAAPLASKAGSAGTNSKPPFPELDFRSGARVEELNKLIQEFTKHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDIDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISSSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLELQRRGSTTSIPSPQSDGGDTNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 491 }, "evidence": [ { "id": "E1B9A3", "url": "https://omabrowser.org/oma/group/E1B9A3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7FBQ4-1", "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "LOC556707", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAPALSSRAASAGNSPTATPSSSKPVPQAPELDFRSGTRIEELNRLIGEFSKHEQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDMDLDELTVYARGADYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTINKWKDCCTMIDHANGATNYFFSPTLVADWFYESISMVLAEIQKKPQRGVPRVEKVERNATVISIILGVGGSRMLYDVVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLLPACSSTGQKENEWRLSFARSEVQLKKCISASLMQAYQACKALIIKLLSRPKAISPYHLRSLMLWSCDRLPHTYLAQEDYAAHFLLGLIDDLQHCLVNKTCPNYFIPQCNMLEHLSDDMAMLHARKLSSVRSDPAEHLRSAIEHAKAASRLTVELQWRSGSSNLPSPLSETGADQQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 499 }, "evidence": [ { "id": "E1B9A3", "url": "https://omabrowser.org/oma/group/E1B9A3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SFH0-1", "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "MB21D2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKMAAPTASKAASLGCNNKPAFPELDFRSGARVEELNKLIQEFTKHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISSSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLELQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 491 }, "evidence": [ { "id": "E1B9A3", "url": "https://omabrowser.org/oma/group/E1B9A3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8C525-1", "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "Mb21d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLQTPMTGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKGCCTIADHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISGSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPASYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLKLQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 428 }, "evidence": [ { "id": "E1B9A3", "url": "https://omabrowser.org/oma/group/E1B9A3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYB1-1", "protein_name": "Nucleotidyltransferase MB21D2", "gene_name": "MB21D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKMAAPTANKAASLGCNNKPAFPELDFRSGARVEELNKLIQEFTKHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISKWKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTIISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPACSYKGKKDNEWRLSFARSEVQLKKCISSSLMQAYQACKAIIIKLLSRPKAISPYHLRSMMLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEETVMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLELQRRGSTTSIPSPQSDGGDPNQPDDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF", "length": 491 }, "evidence": [ { "id": "E1B9A3", "url": "https://omabrowser.org/oma/group/E1B9A3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "E1B9A3", "url": "https://www.uniprot.org/uniprotkb/E1B9A3" } ], "pmid": "" }, { "name": "nucleotidyltransferase activity", "id": "GO:0016779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "evidence": [ { "database": "UniProtKB", "id": "E1B9A3", "url": "https://www.uniprot.org/uniprotkb/E1B9A3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9A3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 491, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9A3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9A3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A3" }, { "id": "PF20266", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20266" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mab-21-like HhH/H2TH-like", "eco_id": "ECO_0000259", "start_pos": 325, "end_pos": 400, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A3" }, { "id": "PF03281", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03281" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mab-21-like nucleotidyltransferase", "eco_id": "ECO_0000259", "start_pos": 136, "end_pos": 298, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 216, "end_pos": 218 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9A8-1", "uniprot_ac": "E1B9A8", "uniprot_id": "E1B9A8_BOVIN", "mass": { "chemical_mass": 79035.0, "monoisotopic_mass": 79035.0 }, "refseq": {}, "gene_names": [ { "name": "CNKSR1", "type": "recommended", "evidence": [ { "id": "E1B9A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" } ] } ], "protein_names": [ { "name": "Connector enhancer of kinase suppressor of Ras 1", "type": "synonym", "evidence": [ { "id": "E1B9A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9A8", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNKSR1", "url": "https://www.uniprot.org/uniprotkb/E1B9A8", "locus": { "chromosome": "2", "start_pos": 126911396, "end_pos": 126923332, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019399", "url": "https://www.ensembl.org/id/ENSBTAG00000019399" } ] } } ], "crossref": [ { "id": "E1B9A8", "url": "https://alphafold.ebi.ac.uk/entry/E1B9A8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019399", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019399", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06748", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06748", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9A8", "url": "https://www.orthodb.org/?gene=E1B9A8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B9A8", "url": "https://www.uniprot.org/uniprotkb/E1B9A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9A8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9A8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVATWTPRKVAAWLRGLDDSLQDYCFEDWELPGKYLLQLCPRSLEALTVWPLGHQEIILEGVEQLRALSSGLQSENLQSLTEGLLEGTQAFQSLVQGRLGGCVETPADVLGAAVQLVHEARSLLFWLNRYLFSHLNDFSSCQAIGELCGELGQALQEDCPAAEKESKVLRISSHVAGICCNILSCCPEELLKQKAVLEQVPLDDPSGLEIHTTSNCLHFVSRVGTQVPTNPQLQVLPGDEIVQVNEQVVVSEGKGTVGWPHKNVVRELLREPDRVSLVLKKVPVPETPQQTPPQPLDSPCPVSPSPAPASVSPRTPSKDIFDFNLSSNPSPGPSPPAWTDSTFLGPKPLPSPPATAATYLAEVADTPERPEHPDRSPVPGCRKSKGVATRRRVSCRELGPPDCDGWLLLRKVPGGFMGPRWRRCWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGQDQKKKYVFQLTHNVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRASLPREEDCYSETEAEDPDDEAGSCSASPSPAQATSSLHGDPSPAVTPQDSPRTSFSPATDSSEGALEGMVRGLRLGGVSLLGQQQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKLQELQALEEVLGDPELTGEKFRRWKEQNQELYSEGLGAWGGEQAQGGSQVLNSDPKEQSSHPPPSDPEECSPLCPLTPESDPRPPDL", "length": 718, "header": "tr|E1B9A8-1|E1B9A8_BOVIN Isoform 1 of Connector enhancer of kinase suppressor of Ras 1 OS=Bos taurus OX=9913 GN=CNKSR1 PE=4 SV=4 CANONICAL=E1B9A8-1" }, "isoforms": [ { "isoform_ac": "E1B9A8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9A8/entry", "sequence": { "sequence": "MEPVATWTPRKVAAWLRGLDDSLQDYCFEDWELPGKYLLQLCPRSLEALTVWPLGHQEIILEGVEQLRALSSGLQSENLQSLTEGLLEGTQAFQSLVQGRLGGCVETPADVLGAAVQLVHEARSLLFWLNRYLFSHLNDFSSCQAIGELCGELGQALQEDCPAAEKESKVLRISSHVAGICCNILSCCPEELLKQKAVLEQVPLDDPSGLEIHTTSNCLHFVSRVGTQVPTNPQLQVLPGDEIVQVNEQVVVSEGKGTVGWPHKNVVRELLREPDRVSLVLKKVPVPETPQQTPPQPLDSPCPVSPSPAPASVSPRTPSKDIFDFNLSSNPSPGPSPPAWTDSTFLGPKPLPSPPATAATYLAEVADTPERPEHPDRSPVPGCRKSKGVATRRRVSCRELGPPDCDGWLLLRKVPGGFMGPRWRRCWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGQDQKKKYVFQLTHNVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRASLPREEDCYSETEAEDPDDEAGSCSASPSPAQATSSLHGDPSPAVTPQDSPRTSFSPATDSSEGALEGMVRGLRLGGVSLLGQQQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKLQELQALEEVLGDPELTGEKFRRWKEQNQELYSEGLGAWGGEQAQGGSQVLNSDPKEQSSHPPPSDPEECSPLCPLTPESDPRPPDL", "length": 718, "header": "tr|E1B9A8-1|E1B9A8_BOVIN Isoform 1 of Connector enhancer of kinase suppressor of Ras 1 OS=Bos taurus OX=9913 GN=CNKSR1 PE=4 SV=4 CANONICAL=E1B9A8-1" }, "locus": { "chromosome": "2", "start_pos": 126923284, "end_pos": 126911624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025847.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025847.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025847.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025847.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 555, "start_aa": "Thr", "end_pos": 555, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr555", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5674135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "resource": "Reactome", "description": "MAP2K and MAPK activation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "E1B9A8", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "E1B9A8", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "enzyme-linked receptor protein signaling pathway", "id": "GO:0007167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007167", "evidence": [ { "database": "UniProtKB", "id": "E1B9A8", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9A8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 718, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9A8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9A8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" }, { "id": "PS51290", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51290" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRIC", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 164, "start_aa": "Asn", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 402, "end_pos": 501, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B9A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9A8" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 70, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 555 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 326, "end_pos": 328 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 454, "end_pos": 456 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9C9-1", "uniprot_ac": "E1B9C9", "uniprot_id": "E1B9C9_BOVIN", "mass": { "chemical_mass": 41772.0, "monoisotopic_mass": 41772.0 }, "refseq": { "ac": "XP_005208621", "name": "hematopoietic SH2 domain-containing protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208621" }, "gene_names": [ { "name": "HSH2D", "type": "recommended", "evidence": [ { "id": "E1B9C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9C9" } ] }, { "name": "HSH2D", "type": "synonym", "evidence": [ { "id": "XP_005208621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208621" } ] } ], "protein_names": [ { "name": "Hematopoietic SH2 domain containing", "type": "synonym", "evidence": [ { "id": "E1B9C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9C9/entry#names_and_taxonomy" } ] }, { "name": "hematopoietic SH2 domain-containing protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208621" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9C9", "url": "https://www.uniprot.org/uniprotkb/E1B9C9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSH2D", "url": "https://www.uniprot.org/uniprotkb/E1B9C9", "locus": { "chromosome": "7", "start_pos": 6861419, "end_pos": 6870383, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038154", "url": "https://www.ensembl.org/id/ENSBTAG00000038154" } ] } } ], "crossref": [ { "id": "E1B9C9", "url": "https://alphafold.ebi.ac.uk/entry/E1B9C9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038154", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038154", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100848273", "url": "https://www.ncbi.nlm.nih.gov/gene/100848273", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9C9", "url": "https://www.orthodb.org/?gene=E1B9C9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14388:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14388:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208621", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208621", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9C9", "url": "https://www.uniprot.org/uniprotkb/E1B9C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9C9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9C9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTRLDQKESQGWRGPERQEEPSGGTGQPSPLEAMTEARRLPPPLPPRLDWFVQTQVDQLTCEGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQNCCHHFMVKLLDDGSFTIPGEERVHDSLDALVTFYQQQPLRPHGDLLMQSCPQRDPVNVDYEDLFLYSNALVEEDSSSALGFSEHQIPSSYPIAPLKEASAKPGPLHRSKERKLSAGLKGASMEGPLEEARQKLWRNLRMLPKTGRKVQKQLKSHLATLSSSSVTNGSETGTGDTAWENNVDKDPFVATSLASPAQPQAPRNRQGPSRKTSRSVSWNEAASKVKDWHQTVVRVLSLQASKPGPVDLREPQDSLPEEYRPPPPFAPGYC", "length": 376, "header": "tr|E1B9C9-1|E1B9C9_BOVIN Isoform 1 of Hematopoietic SH2 domain containing OS=Bos taurus OX=9913 GN=HSH2D PE=4 SV=3 CANONICAL=E1B9C9-1" }, "isoforms": [ { "isoform_ac": "E1B9C9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9C9/entry", "sequence": { "sequence": "MGTRLDQKESQGWRGPERQEEPSGGTGQPSPLEAMTEARRLPPPLPPRLDWFVQTQVDQLTCEGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQNCCHHFMVKLLDDGSFTIPGEERVHDSLDALVTFYQQQPLRPHGDLLMQSCPQRDPVNVDYEDLFLYSNALVEEDSSSALGFSEHQIPSSYPIAPLKEASAKPGPLHRSKERKLSAGLKGASMEGPLEEARQKLWRNLRMLPKTGRKVQKQLKSHLATLSSSSVTNGSETGTGDTAWENNVDKDPFVATSLASPAQPQAPRNRQGPSRKTSRSVSWNEAASKVKDWHQTVVRVLSLQASKPGPVDLREPQDSLPEEYRPPPPFAPGYC", "length": 376, "header": "tr|E1B9C9-1|E1B9C9_BOVIN Isoform 1 of Hematopoietic SH2 domain containing OS=Bos taurus OX=9913 GN=HSH2D PE=4 SV=3 CANONICAL=E1B9C9-1" }, "locus": { "chromosome": "7", "start_pos": 6870122, "end_pos": 6861819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021412.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021412.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021412.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021412.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9C9", "url": "https://www.uniprot.org/uniprotkb/E1B9C9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "E1B9C9", "url": "https://www.uniprot.org/uniprotkb/E1B9C9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "T cell activation", "id": "GO:0042110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042110", "evidence": [ { "database": "UniProtKB", "id": "E1B9C9", "url": "https://www.uniprot.org/uniprotkb/E1B9C9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9C9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9C9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9C9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9C9" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 159, "start_aa": "Trp", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 274, "end_pos": 276 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9E7-1", "uniprot_ac": "E1B9E7", "uniprot_id": "E1B9E7_BOVIN", "mass": { "chemical_mass": 30772.0, "monoisotopic_mass": 30772.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Serine protease 51", "type": "synonym", "evidence": [ { "id": "E1B9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9E7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B9E7", "locus": {} } ], "crossref": [ { "id": "E1B9E7", "url": "https://alphafold.ebi.ac.uk/entry/E1B9E7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038291", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038291", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9E7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQLLIPLLMALKGRAQKTSDEVHCGYRPKFSNSTVLQAHELLNVQDGEFPWQVSIQISQKHLCGGSIIHRWWVLTAAHCFPRTLLEMTLENITVVMGSRTLKDSRLERKQVQKIIIHKDYEPPHLDSDLSLLLLATPVQFNNFKMPICLQKKEKIWGRCWMTEWVMAPSYDRKDNFNMYLQKLRVVQITWRDCSQRVDHLSRNMLCAWQELGTKGNCQGDSGAPMVCTIHGSRRLFQVGVFSWGIRSGFRGRPGMFVSVAQFLPW", "length": 266, "header": "tr|E1B9E7-1|E1B9E7_BOVIN Isoform 1 of Serine protease 51 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B9E7-1" }, "isoforms": [ { "isoform_ac": "E1B9E7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9E7/entry", "sequence": { "sequence": "MLQLLIPLLMALKGRAQKTSDEVHCGYRPKFSNSTVLQAHELLNVQDGEFPWQVSIQISQKHLCGGSIIHRWWVLTAAHCFPRTLLEMTLENITVVMGSRTLKDSRLERKQVQKIIIHKDYEPPHLDSDLSLLLLATPVQFNNFKMPICLQKKEKIWGRCWMTEWVMAPSYDRKDNFNMYLQKLRVVQITWRDCSQRVDHLSRNMLCAWQELGTKGNCQGDSGAPMVCTIHGSRRLFQVGVFSWGIRSGFRGRPGMFVSVAQFLPW", "length": 266, "header": "tr|E1B9E7-1|E1B9E7_BOVIN Isoform 1 of Serine protease 51 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=E1B9E7-1" }, "locus": { "chromosome": "8", "start_pos": 8764467, "end_pos": 8754342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055085.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055085.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053065.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053065.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "E1B9E7", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9E7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 266, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9E7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9E7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9E7" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 266, "start_aa": "Val", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9G6-1", "uniprot_ac": "E1B9G6", "uniprot_id": "E1B9G6_BOVIN", "mass": { "chemical_mass": 39867.0, "monoisotopic_mass": 39867.0 }, "refseq": { "ac": "XP_024842196", "name": "LRP2-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842196" }, "gene_names": [ { "name": "LRP2BP", "type": "recommended", "evidence": [ { "id": "E1B9G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G6" } ] }, { "name": "LRP2BP", "type": "synonym", "evidence": [ { "id": "XP_024842196", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842196" } ] } ], "protein_names": [ { "name": "LRP2-binding protein", "type": "recommended", "evidence": [ { "id": "E1B9G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G6/entry#names_and_taxonomy" } ] }, { "name": "LRP2-binding protein", "type": "synonym", "evidence": [ { "id": "XP_024842196", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842196" } ] } ], "function": [ { "annotation": "May act as an adapter that regulates LRP2 function.", "evidence": [ { "database": "UniProtKB", "id": "E1B9G6", "url": "https://www.uniprot.org/uniprotkb/E1B9G6#function" }, { "database": "UniProtKB", "id": "ARBA00037614", "url": "https://www.uniprot.org/uniprotkb/ARBA00037614#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9G6", "url": "https://www.uniprot.org/uniprotkb/E1B9G6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRP2BP", "url": "https://www.uniprot.org/uniprotkb/E1B9G6", "locus": { "chromosome": "27", "start_pos": 15624842, "end_pos": 15649819, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005094", "url": "https://www.ensembl.org/id/ENSBTAG00000005094" } ] } } ], "crossref": [ { "id": "E1B9G6", "url": "https://alphafold.ebi.ac.uk/entry/E1B9G6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005094", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005094", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536490", "url": "https://www.ncbi.nlm.nih.gov/gene/536490", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR006597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536490", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536490", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TDHYTHA", "url": "https://omabrowser.org/oma/group/TDHYTHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9G6", "url": "https://www.orthodb.org/?gene=E1B9G6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44554", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44554", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44554:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44554:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF08238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842196", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842196", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9G6", "url": "https://www.uniprot.org/uniprotkb/E1B9G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9G6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9G6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLTSEKLPKNPSYTSLSHFAAKNAKVFQWRKEKTDHYSHANLVDKALQLLKERIRRGDTMAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTAADSEKGVEYMKKIVDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSDKEAERLWLFAADNGNPKASVKAQSILGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYFYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFISRGMAMASFYHARCLQLGLGVTKDEATAKRYYSKACRLNPALADELHTLLIHQRI", "length": 348, "header": "tr|E1B9G6-1|E1B9G6_BOVIN Isoform 1 of LRP2-binding protein OS=Bos taurus OX=9913 GN=LRP2BP PE=1 SV=2 CANONICAL=E1B9G6-1" }, "isoforms": [ { "isoform_ac": "E1B9G6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9G6/entry", "sequence": { "sequence": "MKLTSEKLPKNPSYTSLSHFAAKNAKVFQWRKEKTDHYSHANLVDKALQLLKERIRRGDTMAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTAADSEKGVEYMKKIVDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSDKEAERLWLFAADNGNPKASVKAQSILGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYFYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFISRGMAMASFYHARCLQLGLGVTKDEATAKRYYSKACRLNPALADELHTLLIHQRI", "length": 348, "header": "tr|E1B9G6-1|E1B9G6_BOVIN Isoform 1 of LRP2-binding protein OS=Bos taurus OX=9913 GN=LRP2BP PE=1 SV=2 CANONICAL=E1B9G6-1" }, "locus": { "chromosome": "27", "start_pos": 15644487, "end_pos": 15624892, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006705.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006705.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006705.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006705.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1B9G6", "url": "https://www.uniprot.org/uniprotkb/E1B9G6" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:536490", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536490", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VWH5-1", "protein_name": "LRP2-binding protein", "gene_name": "LRP2BP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKLTSEKLPKNPFYLSLSPYAAKNPKLFQWRKEKTDHYNHANLVDKALQLLKERIRRGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTTDAEKGVEYMKKIVDSPCPKARHLQFAAAYNLGRAYYEGKGVKRSDEEAERLWLFAADNGNPKASVKAQSILGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYFYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQLTDCLPEFISKGMAMASFYHARCLQLGLGITKDEATAKHYYSKACRLNPALADELHTLLIRQRI", "length": 348 }, "evidence": [ { "id": "E1B9G6", "url": "https://omabrowser.org/oma/group/E1B9G6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q569C2-1", "protein_name": "LRP2-binding protein", "gene_name": "Lrp2bp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLTSEKLPKNPFSLSQYAAKQQTFFQWKKEKPDYYRHANLVDTALQFLKERIRKGDAMAYFLRGQLYFEEGWYEEALAQFEEIQEKDHQAIYQLGVMYYDGLGTVADAEKGVGYMKKILDSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLYAADNGNPKASVKAQSILGLFYSMKEPKDLEKAFFWHSEACGNGNLESQGALGLMYLYGQGIRQDTDAALHCLREAAERGNVYAQGILVEYYYKMKFFTKCVSFSKRIADYDEVHDIPMIAHVTDCLPEFISKGMAMASFYYARCLQLGLGITKDEASAKHYYSKACRLNPTLADELHSLLIHQRI", "length": 346 }, "evidence": [ { "id": "E1B9G6", "url": "https://omabrowser.org/oma/group/E1B9G6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D4C6-1", "protein_name": "LRP2-binding protein", "gene_name": "Lrp2bp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLSSEKLPKNPFSLSQYAAKQQKFFQWKKEKPDYYLHANLVDTALQFLKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFEEIQEKDHQAIYQLGVMYYDGLGTIANAEKGVNYMRKILDSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKCVSFSKRIADYDEVHDIPMIAHVTDCLPEFIIKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLNPTLADELHSLLIHQRI", "length": 346 }, "evidence": [ { "id": "E1B9G6", "url": "https://omabrowser.org/oma/group/E1B9G6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2M1-1", "protein_name": "LRP2-binding protein", "gene_name": "LRP2BP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLTSEKLPKNPFYASVSQYAAKNQKFFQWKKEKTDYTHANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPALADELHSLLIRQRI", "length": 347 }, "evidence": [ { "id": "E1B9G6", "url": "https://omabrowser.org/oma/group/E1B9G6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9G6", "url": "https://www.uniprot.org/uniprotkb/E1B9G6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9G6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 348, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9G6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9G6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9I3-1", "uniprot_ac": "E1B9I3", "uniprot_id": "E1B9I3_BOVIN", "mass": { "chemical_mass": 7841.0, "monoisotopic_mass": 7841.0 }, "refseq": { "ac": "XP_059749051", "name": "protein WFDC10B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749051" }, "gene_names": [ { "name": "WFDC10B", "type": "recommended", "evidence": [ { "id": "E1B9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" } ] }, { "name": "WFDC10B", "type": "synonym", "evidence": [ { "id": "XP_059749051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749051" } ] } ], "protein_names": [ { "name": "WAP four-disulfide core domain 10B", "type": "synonym", "evidence": [ { "id": "E1B9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9I3/entry#names_and_taxonomy" } ] }, { "name": "protein WFDC10B", "type": "synonym", "evidence": [ { "id": "XP_059749051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749051" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9I3", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WFDC10B", "url": "https://www.uniprot.org/uniprotkb/E1B9I3", "locus": { "chromosome": "13", "start_pos": 74476374, "end_pos": 74477530, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030800", "url": "https://www.ensembl.org/id/ENSBTAG00000030800" } ] } } ], "crossref": [ { "id": "E1B9I3", "url": "https://alphafold.ebi.ac.uk/entry/E1B9I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030800", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030800", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "132346975", "url": "https://www.ncbi.nlm.nih.gov/gene/132346975", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:132346975", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132346975", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PF00095", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00095", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059749051", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749051", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9I3", "url": "https://www.uniprot.org/uniprotkb/E1B9I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9I3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAQALLLLCVLLLQAPGGQHSQKTNHLKAKACTKRPTEFTCGNHCSYFQHCPQNTICCSTFCGNICMNVL", "length": 71, "header": "tr|E1B9I3-1|E1B9I3_BOVIN Isoform 1 of WAP four-disulfide core domain 10B OS=Bos taurus OX=9913 GN=WFDC10B PE=4 SV=3 CANONICAL=E1B9I3-1" }, "isoforms": [ { "isoform_ac": "E1B9I3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9I3/entry", "sequence": { "sequence": "MRAQALLLLCVLLLQAPGGQHSQKTNHLKAKACTKRPTEFTCGNHCSYFQHCPQNTICCSTFCGNICMNVL", "length": 71, "header": "tr|E1B9I3-1|E1B9I3_BOVIN Isoform 1 of WAP four-disulfide core domain 10B OS=Bos taurus OX=9913 GN=WFDC10B PE=4 SV=3 CANONICAL=E1B9I3-1" }, "locus": { "chromosome": "13", "start_pos": 74477530, "end_pos": 74476377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043530.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043530.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041094.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041094.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132346975", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132346975", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1B9I3", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B9I3", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "antibacterial humoral response", "id": "GO:0019731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019731", "evidence": [ { "database": "UniProtKB", "id": "E1B9I3", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1B9I3", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9I3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 71, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9I3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9I3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9I3" }, { "id": "PS51390", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51390" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WAP", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 71, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9L3-1", "uniprot_ac": "E1B9L3", "uniprot_id": "E1B9L3_BOVIN", "mass": { "chemical_mass": 8936.0, "monoisotopic_mass": 8936.0 }, "refseq": { "ac": "XP_005215100", "name": "WAP four-disulfide core domain protein 10A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215100" }, "gene_names": [ { "name": "WFDC10A", "type": "recommended", "evidence": [ { "id": "E1B9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" } ] }, { "name": "WFDC10A", "type": "synonym", "evidence": [ { "id": "XP_005215100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215100" } ] } ], "protein_names": [ { "name": "WAP four-disulfide core domain 10A", "type": "synonym", "evidence": [ { "id": "E1B9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9L3/entry#names_and_taxonomy" } ] }, { "name": "WAP four-disulfide core domain protein 10A", "type": "synonym", "evidence": [ { "id": "XP_005215100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215100" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9L3", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WFDC10A", "url": "https://www.uniprot.org/uniprotkb/E1B9L3", "locus": { "chromosome": "13", "start_pos": 74461350, "end_pos": 74457949, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030796", "url": "https://www.ensembl.org/id/ENSBTAG00000030796" } ] } } ], "crossref": [ { "id": "E1B9L3", "url": "https://alphafold.ebi.ac.uk/entry/E1B9L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030796", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030796", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100296236", "url": "https://www.ncbi.nlm.nih.gov/gene/100296236", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296236", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296236", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PF00095", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00095", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215100", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215100", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9L3", "url": "https://www.uniprot.org/uniprotkb/E1B9L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9L3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAQALLPILLLCVLLLQARGRQHSQKTNQKQQPPEIKQCEKRPKIYMCKIPCTDDRECQANNICCSTFCGNICMNVL", "length": 78, "header": "tr|E1B9L3-1|E1B9L3_BOVIN Isoform 1 of WAP four-disulfide core domain 10A OS=Bos taurus OX=9913 GN=WFDC10A PE=4 SV=3 CANONICAL=E1B9L3-1" }, "isoforms": [ { "isoform_ac": "E1B9L3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9L3/entry", "sequence": { "sequence": "MRAQALLPILLLCVLLLQARGRQHSQKTNQKQQPPEIKQCEKRPKIYMCKIPCTDDRECQANNICCSTFCGNICMNVL", "length": 78, "header": "tr|E1B9L3-1|E1B9L3_BOVIN Isoform 1 of WAP four-disulfide core domain 10A OS=Bos taurus OX=9913 GN=WFDC10A PE=4 SV=3 CANONICAL=E1B9L3-1" }, "locus": { "chromosome": "13", "start_pos": 74461198, "end_pos": 74460038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043525.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043525.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041089.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041089.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296236", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296236", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1B9L3", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B9L3", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "antibacterial humoral response", "id": "GO:0019731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019731", "evidence": [ { "database": "UniProtKB", "id": "E1B9L3", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1B9L3", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9L3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 78, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9L3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9L3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9L3" }, { "id": "PS51390", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51390" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WAP", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 78, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9P6-1", "uniprot_ac": "E1B9P6", "uniprot_id": "E1B9P6_BOVIN", "mass": { "chemical_mass": 34919.0, "monoisotopic_mass": 34919.0 }, "refseq": { "ac": "NP_001377650", "name": "olfactory receptor family 1 subfamily J member 4E", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377650" }, "gene_names": [ { "name": "OR1J4E", "type": "recommended", "evidence": [ { "id": "E1B9P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" } ] }, { "name": "OR1J4E", "type": "synonym", "evidence": [ { "id": "NP_001377650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377650" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 1 subfamily J member 4E", "type": "synonym", "evidence": [ { "id": "E1B9P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9P6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 1 subfamily J member 4E", "type": "synonym", "evidence": [ { "id": "NP_001377650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377650" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377650" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1J4E", "url": "https://www.uniprot.org/uniprotkb/E1B9P6", "locus": { "chromosome": "11", "start_pos": 93566173, "end_pos": 93565232, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055577", "url": "https://www.ensembl.org/id/ENSBTAG00000055577" } ] } } ], "crossref": [ { "id": "E1B9P6", "url": "https://alphafold.ebi.ac.uk/entry/E1B9P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038726", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038726", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15918", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15918", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100851523", "url": "https://www.ncbi.nlm.nih.gov/gene/100851523", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100851523", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100851523", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9P6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRENQSSVSEFLLLGLPIWPEQQGMFFTLFLGVYLTTVLGNLLILLLIRLDARLHTPMYFFLSHLALTDVSFSSVTVPKMLINMQTQHQSISYVGCVTQTYFFLFFTDLDDFLLTSMAYDRYVAICHPLHYSTVMGQGLCTLLVTVSWILSCASALCHTLLLTRMSFCADHSIPHFFCDLDALLKLSCSDTSLNKLAIFTVGVAVIVLPLVCILISYGRIGATILKVPSTKGICKALSTCGSHLSVVFLFYGTIIGLYTLPSSSTSNDKNIIASVMYTAVTPMLNPFIYSLRNREMKGALGRLSRREIFFSK", "length": 313, "header": "tr|E1B9P6-1|E1B9P6_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily J member 4E OS=Bos taurus OX=9913 GN=OR1J4E PE=3 SV=3 CANONICAL=E1B9P6-1" }, "isoforms": [ { "isoform_ac": "E1B9P6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9P6/entry", "sequence": { "sequence": "MRRENQSSVSEFLLLGLPIWPEQQGMFFTLFLGVYLTTVLGNLLILLLIRLDARLHTPMYFFLSHLALTDVSFSSVTVPKMLINMQTQHQSISYVGCVTQTYFFLFFTDLDDFLLTSMAYDRYVAICHPLHYSTVMGQGLCTLLVTVSWILSCASALCHTLLLTRMSFCADHSIPHFFCDLDALLKLSCSDTSLNKLAIFTVGVAVIVLPLVCILISYGRIGATILKVPSTKGICKALSTCGSHLSVVFLFYGTIIGLYTLPSSSTSNDKNIIASVMYTAVTPMLNPFIYSLRNREMKGALGRLSRREIFFSK", "length": 313, "header": "tr|E1B9P6-1|E1B9P6_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily J member 4E OS=Bos taurus OX=9913 GN=OR1J4E PE=3 SV=3 CANONICAL=E1B9P6-1" }, "locus": { "chromosome": "11", "start_pos": 93566170, "end_pos": 93565232, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056076.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056076.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049831.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049831.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 282, "start_aa": "Thr", "end_pos": 282, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100851523", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100851523", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1B9P6", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9P6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9P6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9P6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9P6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 282 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9Q9-1", "uniprot_ac": "E1B9Q9", "uniprot_id": "E1B9Q9_BOVIN", "mass": { "chemical_mass": 38858.0, "monoisotopic_mass": 38858.0 }, "refseq": {}, "gene_names": [ { "name": "CALHM6", "type": "recommended", "evidence": [ { "id": "E1B9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ] } ], "protein_names": [ { "name": "Calcium homeostasis modulator family member 6", "type": "synonym", "evidence": [ { "id": "E1B9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CALHM6", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9", "locus": { "chromosome": "9", "start_pos": 34245687, "end_pos": 34248153, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006549", "url": "https://www.ensembl.org/id/ENSBTAG00000006549" } ] } } ], "crossref": [ { "id": "E1B9Q9", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Q9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006549", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006549", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9Q9", "url": "https://www.orthodb.org/?gene=E1B9Q9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32261", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32261:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32261:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKFREVLNLHLKHRNALGYCLVSLLTAGGERIFSTTVFQCPCSVAWNLPYGLVFLLVPALALFLLGYVLSARTWRLLTGCCARSCGSGLRGALVCAQISATAAVAPLTWVAVALLGGAFYECAASGSEVLARYLCVGRDPRCAAQLPLVPCQQAQAPDVKQLQKELQKELTAHSQVGRPRRMRCGGRRGTGFCGADGRWKCVPFLLTPKVLGWVLIAVVIILLLICTSITRCLSPVSYLQLKFWKIYLQQEQQILKSQATEHAMQLAKENIKCFFECSHPQEYNTPSIKDWQQISSLYTFNPKEQYYSTLHKYVNKKQKNQSSTSSEEDAMVPVLGFVDSSDMNSTTDL", "length": 350, "header": "tr|E1B9Q9-1|E1B9Q9_BOVIN Isoform 1 of Calcium homeostasis modulator family member 6 OS=Bos taurus OX=9913 GN=CALHM6 PE=3 SV=3 CANONICAL=E1B9Q9-1" }, "isoforms": [ { "isoform_ac": "E1B9Q9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9/entry", "sequence": { "sequence": "MEKFREVLNLHLKHRNALGYCLVSLLTAGGERIFSTTVFQCPCSVAWNLPYGLVFLLVPALALFLLGYVLSARTWRLLTGCCARSCGSGLRGALVCAQISATAAVAPLTWVAVALLGGAFYECAASGSEVLARYLCVGRDPRCAAQLPLVPCQQAQAPDVKQLQKELQKELTAHSQVGRPRRMRCGGRRGTGFCGADGRWKCVPFLLTPKVLGWVLIAVVIILLLICTSITRCLSPVSYLQLKFWKIYLQQEQQILKSQATEHAMQLAKENIKCFFECSHPQEYNTPSIKDWQQISSLYTFNPKEQYYSTLHKYVNKKQKNQSSTSSEEDAMVPVLGFVDSSDMNSTTDL", "length": 350, "header": "tr|E1B9Q9-1|E1B9Q9_BOVIN Isoform 1 of Calcium homeostasis modulator family member 6 OS=Bos taurus OX=9913 GN=CALHM6 PE=3 SV=3 CANONICAL=E1B9Q9-1" }, "locus": { "chromosome": "9", "start_pos": 34248150, "end_pos": 34245950, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038044.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038044.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037863.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037863.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "pmid": "" }, { "name": "immunological synapse", "id": "GO:0001772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "monoatomic cation channel activity", "id": "GO:0005261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005261", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "pmid": "" }, { "name": "voltage-gated channel activity", "id": "GO:0022832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022832", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ATP export", "id": "GO:1904669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904669", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "pmid": "" }, { "name": "regulation of natural killer cell cytokine production", "id": "GO:0002727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002727", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q9", "url": "https://www.uniprot.org/uniprotkb/E1B9Q9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9Q9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 350, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9Q9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9Q9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 321, "end_pos": 323 }, { "start_pos": 345, "end_pos": 347 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9U6-1", "uniprot_ac": "E1B9U6", "uniprot_id": "E1B9U6_BOVIN", "mass": { "chemical_mass": 54761.0, "monoisotopic_mass": 54761.0 }, "refseq": { "ac": "XP_015315776", "name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315776" }, "gene_names": [ { "name": "LOC521021", "type": "recommended", "evidence": [ { "id": "E1B9U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U6" } ] }, { "name": "LOC521021", "type": "synonym", "evidence": [ { "id": "XP_015315776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315776" } ] } ], "protein_names": [ { "name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like", "type": "recommended", "evidence": [ { "id": "E1B9U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U6/entry#names_and_taxonomy" } ] }, { "name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 7", "type": "synonym", "evidence": [ { "id": "XP_015315776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315776" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9U6", "url": "https://www.uniprot.org/uniprotkb/E1B9U6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC521021", "url": "https://www.uniprot.org/uniprotkb/E1B9U6", "locus": {} } ], "crossref": [ { "id": "E1B9U6", "url": "https://alphafold.ebi.ac.uk/entry/E1B9U6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026383", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026383", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16018", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16018", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521021", "url": "https://www.ncbi.nlm.nih.gov/gene/521021", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521021", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521021", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10151:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10151:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015315776", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315776", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9U6", "url": "https://www.uniprot.org/uniprotkb/E1B9U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGPRALALLLLPVLLGWAGGHPVPGTKSFRKLLLISFDGFRWDYDQDVDTPNMDRLAQEGVKAKYLTPPFVTMTSPSHFTTISGRWIEDHGVIHNMMFNTETQWKYSFKTTQNKTEWWDNGVLPLWITAQRQGRKTASFHYPGGGAKYQGEAVQRSLVESHTHPNGNETEWRQNIDIVMNWFTKEDFDFVTLYYGEPDSVGHLYGPDTENRRAMIQQIDRTIGYLLEAIGRHSLTEHLNVIITSDHGMTTMKKKPNITEILLRNYISFKDLVQFDIVDYGGFGMLLPKPGQEEAVYQALKNAHPHLNVYKKEEFPERFHFAKHERVLPIVMYADPGYSISGRIILYFNKGDHGFDNVYMDMKTIFRAFGPDFKKNHLAEPFDSIHIYPLMCKLLGVTPEPHNGSLAVTQEMLVDTYDQHTGAEMKRASALQNTAISLTVVTGVLVVLFVAGVTFTVFCRKKTQRADQNSTSEPVRMTEL", "length": 480, "header": "tr|E1B9U6-1|E1B9U6_BOVIN Isoform 1 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like OS=Bos taurus OX=9913 GN=LOC521021 PE=4 SV=4 CANONICAL=E1B9U6-1" }, "isoforms": [ { "isoform_ac": "E1B9U6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U6/entry", "sequence": { "sequence": "MTGPRALALLLLPVLLGWAGGHPVPGTKSFRKLLLISFDGFRWDYDQDVDTPNMDRLAQEGVKAKYLTPPFVTMTSPSHFTTISGRWIEDHGVIHNMMFNTETQWKYSFKTTQNKTEWWDNGVLPLWITAQRQGRKTASFHYPGGGAKYQGEAVQRSLVESHTHPNGNETEWRQNIDIVMNWFTKEDFDFVTLYYGEPDSVGHLYGPDTENRRAMIQQIDRTIGYLLEAIGRHSLTEHLNVIITSDHGMTTMKKKPNITEILLRNYISFKDLVQFDIVDYGGFGMLLPKPGQEEAVYQALKNAHPHLNVYKKEEFPERFHFAKHERVLPIVMYADPGYSISGRIILYFNKGDHGFDNVYMDMKTIFRAFGPDFKKNHLAEPFDSIHIYPLMCKLLGVTPEPHNGSLAVTQEMLVDTYDQHTGAEMKRASALQNTAISLTVVTGVLVVLFVAGVTFTVFCRKKTQRADQNSTSEPVRMTEL", "length": 480, "header": "tr|E1B9U6-1|E1B9U6_BOVIN Isoform 1 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like OS=Bos taurus OX=9913 GN=LOC521021 PE=4 SV=4 CANONICAL=E1B9U6-1" }, "locus": { "chromosome": "25", "start_pos": 4150780, "end_pos": 4114967, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037483.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037483.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037314.6", "url": "https://www.ensembl.org/id/ENSBTAP00000037314.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521021", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521021", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphoric diester hydrolase activity", "id": "GO:0008081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008081", "evidence": [ { "database": "UniProtKB", "id": "E1B9U6", "url": "https://www.uniprot.org/uniprotkb/E1B9U6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9U6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 480, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9U6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9U6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 168, "end_pos": 170 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 469, "end_pos": 471 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9Y0-1", "uniprot_ac": "E1B9Y0", "uniprot_id": "E1B9Y0_BOVIN", "mass": { "chemical_mass": 52553.0, "monoisotopic_mass": 52553.0 }, "refseq": { "ac": "NP_001192393", "name": "BTB/POZ domain-containing protein 17 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192393" }, "gene_names": [ { "name": "BTBD17", "type": "recommended", "evidence": [ { "id": "E1B9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0" } ] }, { "name": "BTBD17", "type": "synonym", "evidence": [ { "id": "NP_001192393", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192393" } ] } ], "protein_names": [ { "name": "BTB domain containing 17", "type": "synonym", "evidence": [ { "id": "E1B9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein 17 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192393", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192393" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Y0", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTBD17", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0", "locus": { "chromosome": "19", "start_pos": 57051574, "end_pos": 57046398, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030166", "url": "https://www.ensembl.org/id/ENSBTAG00000030166" } ] } } ], "crossref": [ { "id": "ENSBTAG00000030166", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030166", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18493", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18493", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789790", "url": "https://www.ncbi.nlm.nih.gov/gene/789790", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789790", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789790", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B9Y0", "url": "https://www.orthodb.org/?gene=E1B9Y0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24410", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24410", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24410:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24410:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192393", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9Y0", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Y0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCRLGSAKPGSWASFWAMLTLVGLVTRAAQKADVGGESAGTSINHSQMLLQRLQELLRQGNASDVVLRVQAMGTDEVRVFHAHRLLLGLQSEQFRELLSNQSEVVLQESRDCAAVFDKFIRYLYCGELTVLLAQAIPLHQLATKYRVASLQRGVADYMRAHLAGGAGPAVGWYHYAVSTGDEALRQSCLQFLAWNLSAVAGSAEWGAVSPELLAQLLPRSDLVLQDELELFQALEAWLGRARPPPAVAERALRAIRYPMIPPAQLFQLQARSAALARHGPAVADLLLQAYQFHAASPLHYAKFFDVNGSAFLPRNYLAPAWGAPWVINNPARDDRSTSFQTQLGPSGHDSGRRVTWNVLFSPRWLPVSLRPVYADATGTALPLARPEDGRPRLVVTPASSGGDAAGVSFQKTVLVGARHHGRLLVRHAYSFHQSSEEAGDFLAHADLQRRNSEYLVENALHLHLIVKPVYHTLIRTPK", "length": 478, "header": "tr|E1B9Y0-1|E1B9Y0_BOVIN Isoform 1 of BTB domain containing 17 OS=Bos taurus OX=9913 GN=BTBD17 PE=4 SV=4 CANONICAL=E1B9Y0-1" }, "isoforms": [ { "isoform_ac": "E1B9Y0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0/entry", "sequence": { "sequence": "MCRLGSAKPGSWASFWAMLTLVGLVTRAAQKADVGGESAGTSINHSQMLLQRLQELLRQGNASDVVLRVQAMGTDEVRVFHAHRLLLGLQSEQFRELLSNQSEVVLQESRDCAAVFDKFIRYLYCGELTVLLAQAIPLHQLATKYRVASLQRGVADYMRAHLAGGAGPAVGWYHYAVSTGDEALRQSCLQFLAWNLSAVAGSAEWGAVSPELLAQLLPRSDLVLQDELELFQALEAWLGRARPPPAVAERALRAIRYPMIPPAQLFQLQARSAALARHGPAVADLLLQAYQFHAASPLHYAKFFDVNGSAFLPRNYLAPAWGAPWVINNPARDDRSTSFQTQLGPSGHDSGRRVTWNVLFSPRWLPVSLRPVYADATGTALPLARPEDGRPRLVVTPASSGGDAAGVSFQKTVLVGARHHGRLLVRHAYSFHQSSEEAGDFLAHADLQRRNSEYLVENALHLHLIVKPVYHTLIRTPK", "length": 478, "header": "tr|E1B9Y0-1|E1B9Y0_BOVIN Isoform 1 of BTB domain containing 17 OS=Bos taurus OX=9913 GN=BTBD17 PE=4 SV=4 CANONICAL=E1B9Y0-1" }, "locus": { "chromosome": "19", "start_pos": 57051526, "end_pos": 57046452, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078591.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078591.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789790", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789790", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y0" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 63, "end_pos": 132, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9Y3-1", "uniprot_ac": "E1B9Y3", "uniprot_id": "E1B9Y3_BOVIN", "mass": { "chemical_mass": 21636.0, "monoisotopic_mass": 21636.0 }, "refseq": { "ac": "XP_024855510", "name": "epididymal-specific lipocalin-12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855510" }, "gene_names": [ { "name": "LCN12", "type": "recommended", "evidence": [ { "id": "E1B9Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3" } ] }, { "name": "LCN12", "type": "synonym", "evidence": [ { "id": "XP_024855510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855510" } ] } ], "protein_names": [ { "name": "Lipocalin 12", "type": "synonym", "evidence": [ { "id": "E1B9Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3/entry#names_and_taxonomy" } ] }, { "name": "epididymal-specific lipocalin-12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024855510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855510" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Y3", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LCN12", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3", "locus": { "chromosome": "11", "start_pos": 105996729, "end_pos": 105992719, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039531", "url": "https://www.ensembl.org/id/ENSBTAG00000039531" } ] } } ], "crossref": [ { "id": "E1B9Y3", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Y3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039531", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039531", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "789434", "url": "https://www.ncbi.nlm.nih.gov/gene/789434", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789434", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789434", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCDTWSY", "url": "https://omabrowser.org/oma/group/RCDTWSY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9Y3", "url": "https://www.orthodb.org/?gene=E1B9Y3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-804914", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-804914", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855510", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855510", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B9Y3", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Y3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPWLALWVLLYLPRALQGQSPHTRAAPSSVLQSFEDSKFQGEWYVLGLAGNTHTVADRSLLSPFTATFVLNKNNHLEAAYAMIRGQRCVTWSYELISQSQPGTFSVDHSGEPGADPEEIQVYDTDYASFALLLSKKQSDLQRILRVSLLCRIWAIQTQVLDKFVCLVRAQGLSDDSIVFPDLTEWSVLPEKC", "length": 193, "header": "tr|E1B9Y3-1|E1B9Y3_BOVIN Isoform 1 of Lipocalin 12 OS=Bos taurus OX=9913 GN=LCN12 PE=3 SV=2 CANONICAL=E1B9Y3-1" }, "isoforms": [ { "isoform_ac": "E1B9Y3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3/entry", "sequence": { "sequence": "MGPWLALWVLLYLPRALQGQSPHTRAAPSSVLQSFEDSKFQGEWYVLGLAGNTHTVADRSLLSPFTATFVLNKNNHLEAAYAMIRGQRCVTWSYELISQSQPGTFSVDHSGEPGADPEEIQVYDTDYASFALLLSKKQSDLQRILRVSLLCRIWAIQTQVLDKFVCLVRAQGLSDDSIVFPDLTEWSVLPEKC", "length": 193, "header": "tr|E1B9Y3-1|E1B9Y3_BOVIN Isoform 1 of Lipocalin 12 OS=Bos taurus OX=9913 GN=LCN12 PE=3 SV=2 CANONICAL=E1B9Y3-1" }, "locus": { "chromosome": "11", "start_pos": 105996517, "end_pos": 105992918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032576.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032576.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032507.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032507.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789434", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789434", "resource": "KEGG Pathway" }, { "id": "R-BTA-804914", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-804914", "resource": "Reactome", "description": "Transport of fatty acids" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AN57-1", "protein_name": "Lipocalin 12", "gene_name": "LCN12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGPWWALWVLLSLPKALRGQVTPQTALSSVLQTFQKDQFQGEWIVLALAGSTHKTADRSLLSPFTATFVQNQNDRWEVSYAMIRSKRCVTWSYVLISETQVGKFSVVHSGGSQADQEEVRVYDTDYASFALLLSRRNSGSQSILRVSLLCRAWAIKPQVLRRFVCLVQAQGLADHHIVFPDLSDFLIRPDSC", "length": 192 }, "evidence": [ { "id": "E1B9Y3", "url": "https://omabrowser.org/oma/group/E1B9Y3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B3EY83-1", "protein_name": "Epididymal-specific lipocalin-12", "gene_name": "Lcn12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGPWWALWLILTLPQILGGQSPTMPQGFSQMTSFQSNKFQGEWFVLGLADNTYKREHRPLLHSFITLFKLRDNSEFQVTNSMTRGKHCSTWSYTLIPTNKPGQFTRDNRGSGPGADKENIQVIETDYVKFALVLSLRQASNQNITRVSLLGRDWKITHKTIDRFICLTKTQNLTKNNLLFPDLTDWLLDPKVC", "length": 193 }, "evidence": [ { "id": "E1B9Y3", "url": "https://omabrowser.org/oma/group/E1B9Y3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6JVE5-1", "protein_name": "Epididymal-specific lipocalin-12", "gene_name": "LCN12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLLCGLWLWLSLLKVLQAQTPTPLPLPPPMQSFQGNQFQGEWFVLGLAGNSFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQHCDTWSYVLIPAAQPGQFTVDHGVEPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRISLLGRSWLLPPGTLDQFICLGRAQGLSDDNIVFPDVTGWSPQASVC", "length": 192 }, "evidence": [ { "id": "E1B9Y3", "url": "https://omabrowser.org/oma/group/E1B9Y3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6JVL5-1", "protein_name": "Epididymal-specific lipocalin-12", "gene_name": "Lcn12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPWWALWLILTLPQILESQISAMSQGFPQMTSFQSDQFQGEWFVLGLADNTFRREHRALLNFFTTLFELKEKSQFQVTNSMTRGKHCNTWSYTLIPATKPGQFTRDNRGSGPGADRENIQVIETDYITFALVLSLRQTSSQNITRVSLLGRNWRLSHKTIDKFICLTRTQNLTKDNFLFPDLSDWLPDPQVC", "length": 193 }, "evidence": [ { "id": "E1B9Y3", "url": "https://omabrowser.org/oma/group/E1B9Y3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B9Y3", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small molecule binding", "id": "GO:0036094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094", "evidence": [ { "database": "UniProtKB", "id": "E1B9Y3", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9Y3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 193, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9Y3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9Y3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y3" }, { "id": "PF00061", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipocalin/cytosolic fatty-acid binding", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 184, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA10-1", "uniprot_ac": "E1BA10", "uniprot_id": "E1BA10_BOVIN", "mass": { "chemical_mass": 35033.0, "monoisotopic_mass": 35033.0 }, "refseq": {}, "gene_names": [ { "name": "LOC615277", "type": "recommended", "evidence": [ { "id": "E1BA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA10" } ] } ], "protein_names": [ { "name": "Thioesterase domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA10/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA10", "url": "https://www.uniprot.org/uniprotkb/E1BA10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC615277", "url": "https://www.uniprot.org/uniprotkb/E1BA10", "locus": {} } ], "crossref": [ { "id": "E1BA10", "url": "https://alphafold.ebi.ac.uk/entry/E1BA10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03443", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03443", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47362", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47362", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47362:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47362:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BA10", "url": "https://www.uniprot.org/uniprotkb/E1BA10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA10-1", "url": "https://www.uniprot.org/uniprotkb/E1BA10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCNLLTHNCLTSFLVPLPTAWPDAGEGRGMAWPSEDPHRLRLAESEPQGCAQLPGGRLAFGRRFSWRISVGHHAAERSQVAGEAPTGSTPSPSPGWPAPDALVSLGASPTHHPSLLWPQVSRSHLHSDSKDYSLPNSGWSPIMVRLYNELMEKTVDGTWTRLPGYCRSWQFLKEGDLARIAKVVPVQTVEDARLFLRITEMERLGFEYVIFHNDSEKKCVCLFQPGPLLEGLPGIIHGGALGTMIDTTLFMTAYCSANAVFTGTMTITFKSPITLGSVVRLEANITGMEGRKVFLSCEAQSSDRTILFAEASAIFFQMK", "length": 319, "header": "tr|E1BA10-1|E1BA10_BOVIN Isoform 1 of Thioesterase domain-containing protein OS=Bos taurus OX=9913 GN=LOC615277 PE=4 SV=4 CANONICAL=E1BA10-1" }, "isoforms": [ { "isoform_ac": "E1BA10-1", "url": "https://www.uniprot.org/uniprotkb/E1BA10/entry", "sequence": { "sequence": "MCNLLTHNCLTSFLVPLPTAWPDAGEGRGMAWPSEDPHRLRLAESEPQGCAQLPGGRLAFGRRFSWRISVGHHAAERSQVAGEAPTGSTPSPSPGWPAPDALVSLGASPTHHPSLLWPQVSRSHLHSDSKDYSLPNSGWSPIMVRLYNELMEKTVDGTWTRLPGYCRSWQFLKEGDLARIAKVVPVQTVEDARLFLRITEMERLGFEYVIFHNDSEKKCVCLFQPGPLLEGLPGIIHGGALGTMIDTTLFMTAYCSANAVFTGTMTITFKSPITLGSVVRLEANITGMEGRKVFLSCEAQSSDRTILFAEASAIFFQMK", "length": 319, "header": "tr|E1BA10-1|E1BA10_BOVIN Isoform 1 of Thioesterase domain-containing protein OS=Bos taurus OX=9913 GN=LOC615277 PE=4 SV=4 CANONICAL=E1BA10-1" }, "locus": { "chromosome": "22", "start_pos": 12643519, "end_pos": 12637597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020594.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020594.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020594.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020594.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 86, "start_aa": "Thr", "end_pos": 86, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr86", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 89, "start_aa": "Thr", "end_pos": 89, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BA10", "url": "https://www.uniprot.org/uniprotkb/E1BA10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "E1BA10", "url": "https://www.uniprot.org/uniprotkb/E1BA10" } ], "pmid": "" }, { "name": "regulation of mitochondrial membrane permeability involved in apoptotic process", "id": "GO:1902108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902108", "evidence": [ { "database": "UniProtKB", "id": "E1BA10", "url": "https://www.uniprot.org/uniprotkb/E1BA10" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "long-chain fatty acyl-CoA hydrolase activity", "id": "GO:0052816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052816", "evidence": [ { "database": "UniProtKB", "id": "E1BA10", "url": "https://www.uniprot.org/uniprotkb/E1BA10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA10-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA10-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA10" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA10" }, { "id": "PF03061", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioesterase", "eco_id": "ECO_0000259", "start_pos": 234, "end_pos": 304, "start_aa": "Gly", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 86, 89 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 }, { "start_pos": 284, "end_pos": 286 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BA51-1", "uniprot_ac": "E1BA51", "uniprot_id": "E1BA51_BOVIN", "mass": { "chemical_mass": 30319.0, "monoisotopic_mass": 30319.0 }, "refseq": { "ac": "XP_002685835", "name": "UBX domain-containing protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685835" }, "gene_names": [ { "name": "UBXN10", "type": "recommended", "evidence": [ { "id": "E1BA51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ] }, { "name": "UBXN10", "type": "synonym", "evidence": [ { "id": "XP_002685835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685835" } ] } ], "protein_names": [ { "name": "UBX domain protein 10", "type": "synonym", "evidence": [ { "id": "E1BA51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA51/entry#names_and_taxonomy" } ] }, { "name": "UBX domain-containing protein 10", "type": "synonym", "evidence": [ { "id": "XP_002685835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685835" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBXN10", "url": "https://www.uniprot.org/uniprotkb/E1BA51", "locus": { "chromosome": "2", "start_pos": 132443368, "end_pos": 132460898, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063166", "url": "https://www.ensembl.org/id/ENSBTAG00000063166" } ] } } ], "crossref": [ { "id": "ENSBTAG00000040547", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040547", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17076", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17076", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538586", "url": "https://www.ncbi.nlm.nih.gov/gene/538586", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538586", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538586", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ADSFIWQ", "url": "https://omabrowser.org/oma/group/ADSFIWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BA51", "url": "https://www.orthodb.org/?gene=E1BA51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF00789", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00789", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685835", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685835", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA51-1", "url": "https://www.uniprot.org/uniprotkb/E1BA51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEAPVNIAPPECSPVGSTATDSFPWQPDSLNMHVTRPKSAKGRTRPRLHKRLGMEGCSGRAPASLPPAIPCESPSSHKPGACTPGSPDQGAPGEIPELLQQAPFGVSSSLNKYPVLPSINRRTLEEGALETVAKKAGSLQLSSAQALSQEEACTMKMGEKDPQAQTCSPERRVLVRTERQTSSRVGDLEEPSDQEPRLLLAIRSPSGRRFVRHFRPADALQTVVAVAEHKNKAAYRHCSIETMGVPRRRFSDLSKSLQDCGIPNKSVLGISQEEGEGWS", "length": 281, "header": "tr|E1BA51-1|E1BA51_BOVIN Isoform 1 of UBX domain protein 10 OS=Bos taurus OX=9913 GN=UBXN10 PE=4 SV=2 CANONICAL=E1BA51-1" }, "isoforms": [ { "isoform_ac": "E1BA51-1", "url": "https://www.uniprot.org/uniprotkb/E1BA51/entry", "sequence": { "sequence": "MATEAPVNIAPPECSPVGSTATDSFPWQPDSLNMHVTRPKSAKGRTRPRLHKRLGMEGCSGRAPASLPPAIPCESPSSHKPGACTPGSPDQGAPGEIPELLQQAPFGVSSSLNKYPVLPSINRRTLEEGALETVAKKAGSLQLSSAQALSQEEACTMKMGEKDPQAQTCSPERRVLVRTERQTSSRVGDLEEPSDQEPRLLLAIRSPSGRRFVRHFRPADALQTVVAVAEHKNKAAYRHCSIETMGVPRRRFSDLSKSLQDCGIPNKSVLGISQEEGEGWS", "length": 281, "header": "tr|E1BA51-1|E1BA51_BOVIN Isoform 1 of UBX domain protein 10 OS=Bos taurus OX=9913 GN=UBXN10 PE=4 SV=2 CANONICAL=E1BA51-1" }, "locus": { "chromosome": "2", "start_pos": 132454775, "end_pos": 132453933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116195.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116195.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080677.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080677.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538586", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538586", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZLZ1-1", "protein_name": "UBX domain protein 10", "gene_name": "UBXN10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRSSSNMLPRAGGSPAGRDMGTECHQHGPSPSPQNHPEHCREMAKPMDKRRSKPVSWEAMATAALLNPVPLCCYFPSSTAVSVFQPNAITMHMTRPKSAKGRTRSTFNCSGTTGAYPCAVPSSPAAPHDLQSSRRAPPMKTVFPPGQISPEEIPELLQQVPLRSSSSLNKYRVLPSIGRKGVEGAAEQSGHPDVSWGREDDPKTAAPSGDQGSACRPPESHVPNEEALCAPEKLGRKMRQEGPLLSTLSLEEPLQKESRLLLAIRSPSGQRFEHHFKPTDSLQMVLAIAEHQTATKYERCSIETTEVPRRSFCDLNRSLQECGIPHKSVLCIRQAEQQDLQDTDL", "length": 345 }, "evidence": [ { "id": "E1BA51", "url": "https://omabrowser.org/oma/group/E1BA51/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SUN3-1", "protein_name": "UBX domain protein 10", "gene_name": "UBXN10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATEAPVNIAPPECSTAVSTAVDGFLWQRDSLNMHVIRPKSAKGRTRPSLPRPQGPEVCSSRAPSPPPAIPCESPSSQKPGACTPKSPNQWAPDEIPELLQQMPIGSSSSLNKYPVLPSIKRKSLAQGALETTSKKTSALQRSSLQGLYPKETGTLRMSGEDARARPCSLERKFVMQPKKQSSYGAGDLEEPSDQEPRLLLAVRSPSGRRFVRHFRPTDDLQTVVTVAEHKNKATYRHCSIETMEVPRRRFSDLTKSLQECGIAHRSALGIAREDREGWP", "length": 280 }, "evidence": [ { "id": "E1BA51", "url": "https://omabrowser.org/oma/group/E1BA51/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V606-1", "protein_name": "UBX domain-containing protein 10", "gene_name": "Ubxn10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIEAPVNFAPPEHSTVVSTAADSYTWQPSSLRMHVIRPKSAKGRKRPNLHLPQGIGDGSHSGLTSSSPPRSSGSPSNQKREVCATAPASQGAPDEMPELLQQAPIRTASSLNRYPVLPSINRRSSEDGAVDTVSSKTSSLQLSSVQALYQEEARAAVKSSQEDSRTQVCALEKKFIIRTKRQSSSRASNMEEPSDEEPRLLLAVRSPSGQRFVRYFRPSDDLQTVLEVAEQKNKATYQHCIVETMEVPRRRFSDLTKSLQECGILHKSVLGISQEEGEGWP", "length": 282 }, "evidence": [ { "id": "E1BA51", "url": "https://omabrowser.org/oma/group/E1BA51/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0P3Z8-1", "protein_name": "UBX domain-containing protein 10", "gene_name": "ubxn10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MHVTRPKSSKGRSRPMITNSSMIYTPSQPSALSPQPPAAAKTKDKSNQSLRSRAILRRSSQPTTDILTEAYDRPPEEPVSLNRYRVLPSIEKKTSTDNQKCSQCVSRHRKCQHTNARLDVVSDSTPPEESDLLLAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMDVPRRTFSNLTMTLAQCGVLNKSVLCISHDDSEMDLT", "length": 214 }, "evidence": [ { "id": "E1BA51", "url": "https://omabrowser.org/oma/group/E1BA51/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BG34-1", "protein_name": "UBX domain-containing protein 10", "gene_name": "Ubxn10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIEAPVNFAPPERSTVVSTAGDSSTWQPSSLRMHVIRPKSAKGRKRPNLHRPQGMGDGSPSALSSSPPPRSSGSPSNQKPGVCATVSTSQGAPDEMPELLLQQAPTRTASSLNRYPVLPSINRRSLEVGAVDTVASKTSSLQLSSVQALYQEDSSQEDSRTQVCALEKKFIIRTKRQSSSRASNIEEPSDEEPRLLLAVRSPSGQRFVRYFRPSDDLQTVLEVAEQKNKATYQHCSIETMEVPRRRFSDLTKSLQECGILHKSVLGISQEEGEAWP", "length": 277 }, "evidence": [ { "id": "E1BA51", "url": "https://omabrowser.org/oma/group/E1BA51/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96LJ8-1", "protein_name": "UBX domain-containing protein 10", "gene_name": "UBXN10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATEAPVNIAPPECSTVVSTAVDSLIWQPNSLNMHMIRPKSAKGRTRPSLQKSQGVEVCAHHIPSPPPAIPYELPSSQKPGACAPKSPNQGASDEIPELQQQVPTGASSSLNKYPVLPSINRKNLEEEAVETVAKKASSLQLSSIRALYQDETGTMKTSEEDSRARACAVERKFIVRTKKQGSSRAGNLEEPSDQEPRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGISLEDGEGWP", "length": 280 }, "evidence": [ { "id": "E1BA51", "url": "https://omabrowser.org/oma/group/E1BA51/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "pmid": "" }, { "name": "intraciliary transport particle B", "id": "GO:0030992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "E1BA51", "url": "https://www.uniprot.org/uniprotkb/E1BA51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA51" }, { "id": "PS50033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBX", "eco_id": "ECO_0000259", "start_pos": 195, "end_pos": 272, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAA2-1", "uniprot_ac": "E1BAA2", "uniprot_id": "E1BAA2_BOVIN", "mass": { "chemical_mass": 202145.0, "monoisotopic_mass": 202145.0 }, "refseq": { "ac": "XP_002688595", "name": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688595" }, "gene_names": [ { "name": "CPAMD8", "type": "recommended", "evidence": [ { "id": "E1BAA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA2" } ] }, { "name": "CPAMD8", "type": "synonym", "evidence": [ { "id": "XP_002688595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688595" } ] } ], "protein_names": [ { "name": "C3 and PZP like alpha-2-macroglobulin domain containing 8", "type": "synonym", "evidence": [ { "id": "E1BAA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA2/entry#names_and_taxonomy" } ] }, { "name": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002688595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688595" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAA2", "url": "https://www.uniprot.org/uniprotkb/E1BAA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPAMD8", "url": "https://www.uniprot.org/uniprotkb/E1BAA2", "locus": { "chromosome": "7", "start_pos": 6174070, "end_pos": 6073254, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009331", "url": "https://www.ensembl.org/id/ENSBTAG00000009331" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009331", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009331", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02897", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02897", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100298265", "url": "https://www.ncbi.nlm.nih.gov/gene/100298265", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100298265", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100298265", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGCARDC", "url": "https://omabrowser.org/oma/group/CGCARDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAA2", "url": "https://www.orthodb.org/?gene=E1BAA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11412:SF139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11412:SF139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01835", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01835", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07677", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07677", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07678", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07678", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07703", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07703", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17789", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17789", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688595", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAA2", "url": "https://www.uniprot.org/uniprotkb/E1BAA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGARRGGCEQRAPGGEAGTAALGPRPWPGPGQAPSPGAAPPRSGKMWGAQLGPLLRFLLLLLSPRDGVRAEQPQAPGYLIAAPSVFRSGVEEAISVTIFNSPREVMVQAQLVALGKAVAQSQGAIQDKGTIKLKVPTGLRGQALLKVWGRDWRVEEGPLFHNQTSVTVDSRGASVFIQTDKPVYRPKHRVLISIFTVTPDLRPTSEKLEAYILDPRGSRMMEWRHLEPLCCGITNMTFPLSDQPVLGEWFVFVEMQSHVFNRSFEVQKYVLPKFELLIDPPAYIRDLDTCETGTVQARYTFGKPVSGTLTINMTVNGVGYYSQEVGRPILRTTKIHGSQDFSICVKDMIPADVPEHFRGTISIWATVTAVDGSHQVAFDDSTPVQRQLVDVRYSKDTRKQFKPGLSYVGKVELSYPDGSPAEGVTVQIRAELTPKDNIYTVESVSQGGLVEFEIPSIPMSAQHVWLETKVTALSGKPVGAQYLPSYLSLSSWYSPSQCYLQLQPPSHPLQVGEDAYFPVKSTCPCNFTLYYEVAARGNIVLSGQQPAHVTQQRSKRAALEKPIRLMHLSETEPPPAPAAEVSVCMTSLQLAVTPSMVPLGRLLVFYVRENGEGVADSLQFTVETFFENQVSLTYSANETQPGEVVDLRLKAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFRELEDYDVSDIFGVSREDGPFWWTGLTARRHRRSSVFLWPWGVTKDSGFAFAETGLVVMTDLVSLNHRQDGGLYTDEAVPAFQPHTGSLMAAVSSRQPPRAEKRKRTFFPETWVWHCLNISDPSGEETLSVQVPDSITSWVGEAVGLSPGRGLGIAEPTLLKTFKPFFIDFTLPPYVVRGEQAKIPLSIYNYMDTCAEVYMKISVPKGIQFVGHPGKRHLTKKMCVASGETEPMWVVLSFGDLGLSNITAKALAYRETSCCRDGKSVRPPEENYADRRVPIGRDHIRCSVMVEPEGAPRSYTYSAFFCPNERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSPGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASTPTAKILSWDEFRTFWISWHSGLIQVGHGPEPSNESVIMAWTLPKPPEVQFIGFSTGWGSVGEFRIWRKVEADESYSEAFTLGVPHSAIPGSERAAASIIGDVMGPTLNHLSNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTRQLSPEVERETTDHLVQGYQRQLTYKHQDGSYSAFGERDESGSMWLTAFVLKSFAQARSFIFIDPLELEAAKDWIVQQQQADGSFPAVGRILNKDIQGGIHGTVPLTAYVVAALLEVDPASEEERGAITKARHFLESSASLVTDPYSSALTAYALTLLRSPAAPAALRKLRSLAITQDGVTHWSLTGSRDVDKDAFLSFSDGVYQTVVSAEVEMTAYALLTYTLLGDVATALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGVNLTVSLASTNLDYQETFELHRGNQKLLQMAAIPSLPTGLFVSARGEGCCLMQIDVTYNVPDPVAKPSFQLLVNLQEPEAEQQRPPSPASSADDDDPAADQHHQEYQVTLEVCTRWLHAGSSNMAVLEVPLLSGFRADVESLEQLLLDKHVALKRYELAGRRVLFYFDEIPSRCLTCVQFRALREHVVGRTSALPILVYDYYEPAFEATRFYNVSARSPLARELCAGPACNEVERALAQGPGWSPEERGPVAVPEEGVTVTRCGCARACSISGEPVCGSDGVVYASACHLQEAACRRRVRLEPAPPGRCALEQPTPALALYSYEYDLGPLDTGHLAAGHELVDLDKEAEDSQSGFSS", "length": 1839, "header": "tr|E1BAA2-1|E1BAA2_BOVIN Isoform 1 of C3 and PZP like alpha-2-macroglobulin domain containing 8 OS=Bos taurus OX=9913 GN=CPAMD8 PE=3 SV=2 CANONICAL=E1BAA2-1" }, "isoforms": [ { "isoform_ac": "E1BAA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA2/entry", "sequence": { "sequence": "MAPGARRGGCEQRAPGGEAGTAALGPRPWPGPGQAPSPGAAPPRSGKMWGAQLGPLLRFLLLLLSPRDGVRAEQPQAPGYLIAAPSVFRSGVEEAISVTIFNSPREVMVQAQLVALGKAVAQSQGAIQDKGTIKLKVPTGLRGQALLKVWGRDWRVEEGPLFHNQTSVTVDSRGASVFIQTDKPVYRPKHRVLISIFTVTPDLRPTSEKLEAYILDPRGSRMMEWRHLEPLCCGITNMTFPLSDQPVLGEWFVFVEMQSHVFNRSFEVQKYVLPKFELLIDPPAYIRDLDTCETGTVQARYTFGKPVSGTLTINMTVNGVGYYSQEVGRPILRTTKIHGSQDFSICVKDMIPADVPEHFRGTISIWATVTAVDGSHQVAFDDSTPVQRQLVDVRYSKDTRKQFKPGLSYVGKVELSYPDGSPAEGVTVQIRAELTPKDNIYTVESVSQGGLVEFEIPSIPMSAQHVWLETKVTALSGKPVGAQYLPSYLSLSSWYSPSQCYLQLQPPSHPLQVGEDAYFPVKSTCPCNFTLYYEVAARGNIVLSGQQPAHVTQQRSKRAALEKPIRLMHLSETEPPPAPAAEVSVCMTSLQLAVTPSMVPLGRLLVFYVRENGEGVADSLQFTVETFFENQVSLTYSANETQPGEVVDLRLKAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFRELEDYDVSDIFGVSREDGPFWWTGLTARRHRRSSVFLWPWGVTKDSGFAFAETGLVVMTDLVSLNHRQDGGLYTDEAVPAFQPHTGSLMAAVSSRQPPRAEKRKRTFFPETWVWHCLNISDPSGEETLSVQVPDSITSWVGEAVGLSPGRGLGIAEPTLLKTFKPFFIDFTLPPYVVRGEQAKIPLSIYNYMDTCAEVYMKISVPKGIQFVGHPGKRHLTKKMCVASGETEPMWVVLSFGDLGLSNITAKALAYRETSCCRDGKSVRPPEENYADRRVPIGRDHIRCSVMVEPEGAPRSYTYSAFFCPNERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSPGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASTPTAKILSWDEFRTFWISWHSGLIQVGHGPEPSNESVIMAWTLPKPPEVQFIGFSTGWGSVGEFRIWRKVEADESYSEAFTLGVPHSAIPGSERAAASIIGDVMGPTLNHLSNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTRQLSPEVERETTDHLVQGYQRQLTYKHQDGSYSAFGERDESGSMWLTAFVLKSFAQARSFIFIDPLELEAAKDWIVQQQQADGSFPAVGRILNKDIQGGIHGTVPLTAYVVAALLEVDPASEEERGAITKARHFLESSASLVTDPYSSALTAYALTLLRSPAAPAALRKLRSLAITQDGVTHWSLTGSRDVDKDAFLSFSDGVYQTVVSAEVEMTAYALLTYTLLGDVATALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGVNLTVSLASTNLDYQETFELHRGNQKLLQMAAIPSLPTGLFVSARGEGCCLMQIDVTYNVPDPVAKPSFQLLVNLQEPEAEQQRPPSPASSADDDDPAADQHHQEYQVTLEVCTRWLHAGSSNMAVLEVPLLSGFRADVESLEQLLLDKHVALKRYELAGRRVLFYFDEIPSRCLTCVQFRALREHVVGRTSALPILVYDYYEPAFEATRFYNVSARSPLARELCAGPACNEVERALAQGPGWSPEERGPVAVPEEGVTVTRCGCARACSISGEPVCGSDGVVYASACHLQEAACRRRVRLEPAPPGRCALEQPTPALALYSYEYDLGPLDTGHLAAGHELVDLDKEAEDSQSGFSS", "length": 1839, "header": "tr|E1BAA2-1|E1BAA2_BOVIN Isoform 1 of C3 and PZP like alpha-2-macroglobulin domain containing 8 OS=Bos taurus OX=9913 GN=CPAMD8 PE=3 SV=2 CANONICAL=E1BAA2-1" }, "locus": { "chromosome": "7", "start_pos": 6173066, "end_pos": 6073337, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047290.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047290.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044507.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044507.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 595, "start_aa": "Thr", "end_pos": 595, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr595", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100298265", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100298265", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AFR7-1", "protein_name": "C3 and PZP like alpha-2-macroglobulin domain containing 8", "gene_name": "CPAMD8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHRAERRCAWGVLLTLCGLSAAQPRGRQGYLIAAPSVFRSGVEEAVSVTIFNAVKETTVQIQLVVKGETVSRGHGTVLDKGTIKLKVPSGLRGQGHLKVWGNRHVTEEGYIFHNYTTVTIDSKGSSVFIQTDKPVYKPKQKVLINLFTVTSDLRPFNDRIEAYVVDPRGSRMIEWNNLKPFCCGMVNMSFPLSDQPVFGEWLIFAEMQGHTYNKSFEVQKYVLPKFELLIDPPRYIRDLTACEKGTVHARYTFGKPVTGKLIVNMTINGVGYYRHEVGHPVLKTTQIDGSAVFDVCVKEMMPADVPEHFRGTVNIWATVVSSDGSKQVTFDDSTPVQKQLIDIKYSKDTRKQFKPGLPYKGKVEVTYPDGSPADRVTVRIKAELTPKDNVYTSELVSRNGLVEFEIPSIPTAAQYVWLETKVTAIDGRPSGDQYLPNYLSISSWYSPSKCHIQLQAPDKPFQVGEEAWIAVKSTCPCNFTLHYEVASRGNIVLSGLQPSNITQQRSKRATIPFEKSTDVTHFPGAAPTDIPAAEVEVCMTFLRFSVSHNMAPLGRLLVYYVRENGEGVTDSLQFSVKSTFENQVAVTLSANETRPGDVVNIKVRAAKSSCVCIATVDKSVYLLKTGFQLTASQVFKELAEYDVSDAFGAPKEEGHFWWPGMSSRRRRRSSVFPWHWDVTKDARFAFTETGLVVMTDTVSLNHRQNGGMYTDEAVPAFQPHTGTLVATMRSKMAQSRAEKRKRTFFPETWIWHCLNVSNTSGEAELHVEVPDSITTWITEAVGLSEEKGLGIASQTELKTFKPFFIDFTLPYHVIRGEQTKIPLTVYNYLTVCVEVHVKISVPKGIKFVGHPGKHHLTRKKCVAPGEAKPTSIVLSFSELGLSNITAKAFAYGGTNCCQNGMQALKNGKHSEDNYVDKRTPVGVDYVRSSVVIEPEGLSREYTYSVFFCPNEKIHISTPNKYEYQYMQKPAQMTHFDIAVKAHNDAHVALSSGPHDMAEMTEIVIGGHQNTKTWISISKMGEPVVSRDTAGILSWDEFRSFWISWKNGIIQVGHGTRVLNESIIVEWTVPKQFEVKYIGFSTGWGSIGEFKIWRKEETDENHNEAFTLGVPHNIIPGSERATASIIGDVMGPTLNNLDNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTKQLSQEVESEATDYLVQGYQRQLTYKRQDGSYSAFGERDSSGSMWLTAFVLKSFAQSRGFIFIDPKELTAAKEWIIQHQKEDGSFPAMGRILNKDIQGGIHGKISLTAYVVASLLETGVTSEEERSAVDKAKHFLESNLHSAEDPYTTALTAYALTLLHSPAAAVALRKMNSMAITQDGFTHWSLTGSLVTDEDTFMGFNDGLSQSVVSAEVEMTSYALLTYTLLGDVASALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYVGGVNLTISLASTNLDYQETFELNKMNKKVLQTAVIPSIPTGLFVSAKGEGCCLMQIDVTYNVPDPIAKPAFQLLVNLKEPKSEQHLQAPVLLRSLSPDENRSETLHRERAVVDDDDPAADRDHQEYKVILETCTRWLHSGSSNMAVLEVPLFSGFRADIESLEQLLMNKQIGLKRYEVDGRKVLFYFDEIPSQCMTCVKFQAFREYIVGKTAPVPIKVYDYYEPAFEATRFYNVSENSPLARELCDGPTCNEVESSASQWAGFSHSGPCNNIFGCLEDEYFEQCMCSRDCGYDGDPVCGSDGQIYQNHCQMEVASCRNNTRIEQIPMSQCSNSKNLPEERETNSHTAEQPSVQQPPAAEEGPPLQLDLSYYSYEYDPDPYASEADVFEMVAELTTVSTFREADTIQEVVTTIE", "length": 1850 }, "evidence": [ { "id": "E1BAA2", "url": "https://omabrowser.org/oma/group/E1BAA2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8IZJ3-1", "protein_name": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8", "gene_name": "CPAMD8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGALLWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVYSPAFQSGGEEGLWMSNTCTLR", "length": 1885 }, "evidence": [ { "id": "E1BAA2", "url": "https://omabrowser.org/oma/group/E1BAA2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1BAA2", "url": "https://www.uniprot.org/uniprotkb/E1BAA2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BAA2", "url": "https://www.uniprot.org/uniprotkb/E1BAA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "E1BAA2", "url": "https://www.uniprot.org/uniprotkb/E1BAA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1102, "end_pos": 1104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1484, "end_pos": 1486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1695, "end_pos": 1697, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 528, "end_pos": 530, "annotation": "n_glycosylation_sequon" }, { "start_pos": 639, "end_pos": 641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 930, "end_pos": 932, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA2" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 1746, "end_pos": 1793, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 595 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1102, "end_pos": 1104 }, { "start_pos": 1484, "end_pos": 1486 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 1695, "end_pos": 1697 }, { "start_pos": 237, "end_pos": 239 }, { "start_pos": 263, "end_pos": 265 }, { "start_pos": 314, "end_pos": 316 }, { "start_pos": 528, "end_pos": 530 }, { "start_pos": 639, "end_pos": 641 }, { "start_pos": 802, "end_pos": 804 }, { "start_pos": 930, "end_pos": 932 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAB5-1", "uniprot_ac": "E1BAB5", "uniprot_id": "E1BAB5_BOVIN", "mass": { "chemical_mass": 81350.0, "monoisotopic_mass": 81350.0 }, "refseq": { "ac": "XP_005201800", "name": "Golgi integral membrane protein 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201800" }, "gene_names": [ { "name": "GOLIM4", "type": "recommended", "evidence": [ { "id": "E1BAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB5" } ] }, { "name": "GOLIM4", "type": "synonym", "evidence": [ { "id": "XP_005201800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201800" } ] } ], "protein_names": [ { "name": "Golgi integral membrane protein 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201800" } ] }, { "name": "Golgi integral membrane protein 4", "type": "synonym", "evidence": [ { "id": "E1BAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAB5", "url": "https://www.uniprot.org/uniprotkb/E1BAB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLIM4", "url": "https://www.uniprot.org/uniprotkb/E1BAB5", "locus": { "chromosome": "1", "start_pos": 99445684, "end_pos": 99361953, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018727", "url": "https://www.ensembl.org/id/ENSBTAG00000018727" } ] } } ], "crossref": [ { "id": "E1BAB5", "url": "https://alphafold.ebi.ac.uk/entry/E1BAB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018727", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018727", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538532", "url": "https://www.ncbi.nlm.nih.gov/gene/538532", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR042336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAB5", "url": "https://www.orthodb.org/?gene=E1BAB5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N3R5", "url": "https://www.orthodb.org/?gene=G3N3R5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22909:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22909:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005201800", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201800", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAB5", "url": "https://www.uniprot.org/uniprotkb/E1BAB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAB5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3R5", "url": "https://www.uniprot.org/uniprotkb/G3N3R5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3R5-1", "url": "https://www.uniprot.org/uniprotkb/G3N3R5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRRQGEDFSRTFNDHKQRYLQLQQEKEQELSKLKETVYNLREENRQLRRAHQDMHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSFRKPEQTEQQNITQVAHSPQGDSTARDKSPGEPREVSRNSEVWQNHEAAPGRTEETKPYPSTQKEAELQAPAELTRQEAGPKEPEERQVEEEHRRALEEEAMEQVGRPEHLEEEHDPSPEEQDREWTEQRERKEARLAAGEVHAEVHPSAKPVTRLQSPYEEQLEQQRLAVQRAEEAQRLREEQEALHQQRLQGHLLRQHQQQQLLARETARQQQDGLQEGRLQRPEQPRQQARYDAVDNDIVQGAEDQGIQEEEGGAYERDNQHQDEAEEDPENGHELQEQGPHEADPESEGDRAAVEDINPADDPNNQGEDEFEEAGQVREENLPDENEEQKQSHQKQQNAEMEEHLVMAGNPDQQEDNVDEQYQEEGEEEVQEDLTEEKKRELEHNAEETYGENDENADEKNNEGEEQEVRDDNHPKGREEHYEEEDDEEEDGAAAAEKSRQRAEM", "length": 695, "header": "tr|E1BAB5-1|E1BAB5_BOVIN Isoform 1 of Golgi integral membrane protein 4 OS=Bos taurus OX=9913 GN=GOLIM4 PE=4 SV=4 CANONICAL=E1BAB5-1" }, "isoforms": [ { "isoform_ac": "E1BAB5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAB5/entry", "sequence": { "sequence": "MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRRQGEDFSRTFNDHKQRYLQLQQEKEQELSKLKETVYNLREENRQLRRAHQDMHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSFRKPEQTEQQNITQVAHSPQGDSTARDKSPGEPREVSRNSEVWQNHEAAPGRTEETKPYPSTQKEAELQAPAELTRQEAGPKEPEERQVEEEHRRALEEEAMEQVGRPEHLEEEHDPSPEEQDREWTEQRERKEARLAAGEVHAEVHPSAKPVTRLQSPYEEQLEQQRLAVQRAEEAQRLREEQEALHQQRLQGHLLRQHQQQQLLARETARQQQDGLQEGRLQRPEQPRQQARYDAVDNDIVQGAEDQGIQEEEGGAYERDNQHQDEAEEDPENGHELQEQGPHEADPESEGDRAAVEDINPADDPNNQGEDEFEEAGQVREENLPDENEEQKQSHQKQQNAEMEEHLVMAGNPDQQEDNVDEQYQEEGEEEVQEDLTEEKKRELEHNAEETYGENDENADEKNNEGEEQEVRDDNHPKGREEHYEEEDDEEEDGAAAAEKSRQRAEM", "length": 695, "header": "tr|E1BAB5-1|E1BAB5_BOVIN Isoform 1 of Golgi integral membrane protein 4 OS=Bos taurus OX=9913 GN=GOLIM4 PE=4 SV=4 CANONICAL=E1BAB5-1" }, "locus": { "chromosome": "1", "start_pos": 99444006, "end_pos": 99362165, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024928.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024928.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024928.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024928.7" } ] } }, { "isoform_ac": "G3N3R5-1", "url": "https://www.uniprot.org/uniprotkb/G3N3R5/entry", "sequence": { "sequence": "MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRRQGEDFSRTFNDHKQRYLQLQQEKEQELSKLKETVYNLREENRQLRRAHQDMHTQLQDVKTQVAEYKQLKDTLNRIPSFRKPEQTEQQNITQVAHSPQGDSTARDKSPGEPREVSRNSEVWQNHEAAPGRTEETKPYPSTQKEAELQAPAELTRQEAGPKEPEERQVEEEHRRALEEEAMEQVGRPEHLEEEHDPSPEEQDREWTEQRERKEARLAAGEVHAEVHPSAKPVTRLQSPYEEQLEQQRLAVQRAEEAQRLREEQEALHQQRLQGHLLRQHQQQQLLARETARQQQDGLQEGRLQRPEQPRQQARYDAVDNDIVQGAEDQGIQEEEGGAYERDNQHQDEAEEDPENGHELQEQGPHEADPESEGDRAAVEDINPADDPNNQGEDEFEEAGQVREENLPDENEEQKQSHQKQQNAEMEEHLVMAGNPDQQEDNVDEQYQEEGEEEVQEDLTEEKKRELEHNAEETYGENDENADEKNNEGEEQEVRDDNHPKGREEHYEEEDDEEEDGAAAAEKSRQRAEM", "length": 667, "header": "tr|G3N3R5-1|E1BAB5_BOVIN Computationally mapped isoform of Golgi integral membrane protein 4 OS=Bos taurus OX=9913 GN=GOLIM4 PE=4 SV=2 CANONICAL=E1BAB5-1" }, "locus": { "chromosome": "1", "start_pos": 99444006, "end_pos": 99362165, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063751.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063751.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056574.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056574.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BAB5", "url": "https://www.uniprot.org/uniprotkb/E1BAB5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BAB5", "url": "https://www.uniprot.org/uniprotkb/E1BAB5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BAB5", "url": "https://www.uniprot.org/uniprotkb/E1BAB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAB5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 695, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAB5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAB5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAB8-1", "uniprot_ac": "E1BAB8", "uniprot_id": "E1BAB8_BOVIN", "mass": { "chemical_mass": 37527.0, "monoisotopic_mass": 37527.0 }, "refseq": { "ac": "XP_002694187", "name": "transmembrane protein 82", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694187" }, "gene_names": [ { "name": "TMEM82", "type": "recommended", "evidence": [ { "id": "E1BAB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB8" } ] }, { "name": "TMEM82", "type": "synonym", "evidence": [ { "id": "XP_002694187", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694187" } ] } ], "protein_names": [ { "name": "Transmembrane protein 82", "type": "synonym", "evidence": [ { "id": "E1BAB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB8/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 82", "type": "synonym", "evidence": [ { "id": "XP_002694187", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694187" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAB8", "url": "https://www.uniprot.org/uniprotkb/E1BAB8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM82", "url": "https://www.uniprot.org/uniprotkb/E1BAB8", "locus": { "chromosome": "16", "start_pos": 51814568, "end_pos": 51819340, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018724", "url": "https://www.ensembl.org/id/ENSBTAG00000018724" } ] } } ], "crossref": [ { "id": "E1BAB8", "url": "https://alphafold.ebi.ac.uk/entry/E1BAB8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018724", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018724", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508176", "url": "https://www.ncbi.nlm.nih.gov/gene/508176", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508176", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508176", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVCQLYE", "url": "https://omabrowser.org/oma/group/HVCQLYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAB8", "url": "https://www.orthodb.org/?gene=E1BAB8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35257", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35257", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35257:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35257:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15816", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15816", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694187", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694187", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAB8", "url": "https://www.uniprot.org/uniprotkb/E1BAB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAB8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAB8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSLLSPTSWLPSLPSLDWGSGLLDALLQGLVGACAVSILNNLLKVYFFVGCANHPELRLEKQRLQARWASLETVHLAGLALILTVVGVRVAALVVLEFSLRAVSMLLSLDKGSQGTKKLQLYLLCQYSLGCGLICGLSFLQEGAPHGTLNLMLGLGLAALLSTGARRLRHHVCQRYELHGSQRYCGICLSLLAGAHHLPRLLGRTLAVTFIVGNLAAVALINRDFLTTSEAVRFWTPLTICYTLLVIYMQEEQRQRPGLKSHVQTVLVRMCGLFVLLLTVGRWLDLLGIFISLLGELWCLVGVRTLLDLCQIQDFPPQRPSVSAPSQPQPSAPAQPEEGTATS", "length": 344, "header": "tr|E1BAB8-1|E1BAB8_BOVIN Isoform 1 of Transmembrane protein 82 OS=Bos taurus OX=9913 GN=TMEM82 PE=4 SV=3 CANONICAL=E1BAB8-1" }, "isoforms": [ { "isoform_ac": "E1BAB8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAB8/entry", "sequence": { "sequence": "MFSLLSPTSWLPSLPSLDWGSGLLDALLQGLVGACAVSILNNLLKVYFFVGCANHPELRLEKQRLQARWASLETVHLAGLALILTVVGVRVAALVVLEFSLRAVSMLLSLDKGSQGTKKLQLYLLCQYSLGCGLICGLSFLQEGAPHGTLNLMLGLGLAALLSTGARRLRHHVCQRYELHGSQRYCGICLSLLAGAHHLPRLLGRTLAVTFIVGNLAAVALINRDFLTTSEAVRFWTPLTICYTLLVIYMQEEQRQRPGLKSHVQTVLVRMCGLFVLLLTVGRWLDLLGIFISLLGELWCLVGVRTLLDLCQIQDFPPQRPSVSAPSQPQPSAPAQPEEGTATS", "length": 344, "header": "tr|E1BAB8-1|E1BAB8_BOVIN Isoform 1 of Transmembrane protein 82 OS=Bos taurus OX=9913 GN=TMEM82 PE=4 SV=3 CANONICAL=E1BAB8-1" }, "locus": { "chromosome": "16", "start_pos": 51819141, "end_pos": 51815572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024923.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024923.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024923.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024923.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508176", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0PJX8-1", "protein_name": "Transmembrane protein 82", "gene_name": "TMEM82", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSLPSLPSWLPGLPSLEWGSSLLDSLLQGLIGALGVLVLNSLLKVYFFVGCANDPQRRPEKERLRAQWASLETVHLAGLALFLTVVGSRVAALVVLEFSLRAVSTLLSLGKGSQGAAERLQLYLLCQYSLGCGLTCGLSFLQEGAPHRTLNLLLSLGLATLLGLGARRLHRHVCRLYELHSSQRYCGVCLGLLAHAHGLPQLLGRALAIAFAVGDLAAVALINQDFLTTSEAMRFWTPLTICYTLLVIYMQEEQRQHPGLQSQVQTVLVRMGGLFVLLLTVGRWLDLLGILVSLLGELWCLVGVRTLLDLCQIQDFPSQRPPVSTPSQPLPSAPQSQSSAPS", "length": 343 }, "evidence": [ { "id": "E1BAB8", "url": "https://omabrowser.org/oma/group/E1BAB8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1SUU3-1", "protein_name": "Transmembrane protein 82", "gene_name": "TMEM82", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSPLSLPSWLPSLPSLEWGSSLLDALLQGLIGACGVSVLSNLLKVYFFVGCANDPKRQLEKERLRAQWALLETVHLAGLALILTIVGARVAALVVLEFSLRAVSMLLSLDKGSRGPEKLQLYLLCQYSLGCGLTCGLSFLQEGAPHRTLNLLLGLGLASLLSAGARRLRRHVCQLYELHSSQHYCGVCLGLLAGARSLPRLLGRALAVTFMVGNLAAVALINRDFLTTSEAVRFWTPLTICYTLLVIYMQEEQRQHPGLQGQVQTVLVRLGGLFVLLLTVGRWLDLLGILISLLGELWCLVGVRTLLDLCQIQDFPPQRPSVSAPSRPSAPAQPQGTAPS", "length": 341 }, "evidence": [ { "id": "E1BAB8", "url": "https://omabrowser.org/oma/group/E1BAB8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IKZ3-1", "protein_name": "Transmembrane protein 82", "gene_name": "Tmem82", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFSLPSLSSWLPSLPSFEWGSSLFDRLLQGLIGALGVSVLNNLLKVSFFVACVNDPQRQSHKQRLRSQWASLETVHLAGLTLFLTVVGARVAALVVLEFSLRAVSTVLSLGKGSGDKERLQLFLVCQFSLGCGLTCGLSFLQEGAPHCTLNLLLSLGLATMLGLGARRFRRHICSLYELHTSQRYCGVCLGLLAGQHGLPRLLGRTLAVAFAVSDLAAVALINQDFLNTSEAMRFWTPLTICYTLLVIYMQEEQRQHRFSLQGQVQTVLVRMGGLFILLMAVGRWLDLLGVLVSLVAELWSLAGVRTLIDLCQIQGFPSQRPTVTAAVTPGRVSTLTDPCEPRSSAPALSRSEAPS", "length": 356 }, "evidence": [ { "id": "E1BAB8", "url": "https://omabrowser.org/oma/group/E1BAB8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5XIF9-1", "protein_name": "Solute carrier family 25 member 34", "gene_name": "Slc25a34", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLTQAQMAPATDSREMVSPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQAPGTYPRPYRGFVSSVTAVARADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGTVVAGAVAGALGAFVGSPAYLVKTQLQAQTGAAVAVGHQHQHQGVLSALETIWRQQGMLGLWRGVGAAVPRVTVGSAAQLATFTSAKAWVQDQQWFLEDSWLATLAGGMISSIAVVAVMAPFDVVSTRLYNQPVDRAGRGQLYGGLTDCLVKTCQQEGPLALYKGVGPAYLRLGPHTILSMFFWDELRKLALRAQHPGT", "length": 318 }, "evidence": [ { "id": "E1BAB8", "url": "https://omabrowser.org/oma/group/E1BAB8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R115-1", "protein_name": "Transmembrane protein 82", "gene_name": "Tmem82", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSLPSLSSWLPSLPSFEWGSSLFDSLLQGLIGALGVSVLNSLLKVYFFVACVNDPQRQPQKQRLSAQWASLEMLHLAGLTLFLTLIGSRVAALVVLEFSLRAVSTLLSLGKGSGNKERLQLFLVCQFSLGCGLSCGLSFLQEGAPHRSLNLLLSLGLAVLLALGARRLTRHICSLYELHSSQRYCGVCLGLLASQHGMPRLLSRTLTVAFAVSDLAAVALINKDFLSSSEAVRFWTPLTICYTLLVIYMQEEQWQHRFSLQGQVQTVLVRMGGLFLLLMTVGRWLDLLSIFFSLLGELWCLAGIRALIDLCQIQGFPPQRPTVTAAVTAEGESGWTDPCEPRPSTPAPARSAVPS", "length": 356 }, "evidence": [ { "id": "E1BAB8", "url": "https://omabrowser.org/oma/group/E1BAB8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAB8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 344, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAB8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAB8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB8" }, { "id": "PF15816", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15816" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transmembrane protein 82", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 319, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAD1-1", "uniprot_ac": "E1BAD1", "uniprot_id": "E1BAD1_BOVIN", "mass": { "chemical_mass": 43645.0, "monoisotopic_mass": 43645.0 }, "refseq": { "ac": "XP_002685545", "name": "mitochondrial protein C2orf69 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685545" }, "gene_names": [ { "name": "C2H2orf69", "type": "recommended", "evidence": [ { "id": "E1BAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD1" } ] }, { "name": "C2H2orf69", "type": "synonym", "evidence": [ { "id": "XP_002685545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685545" } ] } ], "protein_names": [ { "name": "Chromosome 2 C2orf69 homolog", "type": "synonym", "evidence": [ { "id": "E1BAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD1/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial protein C2orf69 homolog", "type": "synonym", "evidence": [ { "id": "XP_002685545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685545" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAD1", "url": "https://www.uniprot.org/uniprotkb/E1BAD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C2H2orf69", "url": "https://www.uniprot.org/uniprotkb/E1BAD1", "locus": { "chromosome": "2", "start_pos": 88493587, "end_pos": 88480801, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009952", "url": "https://www.ensembl.org/id/ENSBTAG00000009952" } ] } } ], "crossref": [ { "id": "E1BAD1", "url": "https://alphafold.ebi.ac.uk/entry/E1BAD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009952", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009952", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535735", "url": "https://www.ncbi.nlm.nih.gov/gene/535735", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535735", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535735", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DIMSCHP", "url": "https://omabrowser.org/oma/group/DIMSCHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAD1", "url": "https://www.orthodb.org/?gene=E1BAD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31296:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31296:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685545", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685545", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAD1", "url": "https://www.uniprot.org/uniprotkb/E1BAD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWGFRLLRSPPLLLLLPQLGIGIAASSSHAGTMNLGSNSSGGAPCSPSAERRRQQCVQLSTVPGADPQRSNELLLLAAATAGEGPGRRDLSEDPAKEEVQPPPQHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENVATILAHRFPNSYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHSTDFGAFKHLYMLLVNAFNLSQKSLLSKKNVKDSNKDSKASNCRSTSSHTTNGCQGEKERTCEKSDESAVSFFPPSLNGASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKNIKTMYWLDGGHSGGSNTWITYPEVLKEFAQTGIIVHTHVTPYQVHDPMRSWIGKEHKKFVQILGDFGMQVTSQIHFANDAPSIENHFRVHEVF", "length": 390, "header": "tr|E1BAD1-1|E1BAD1_BOVIN Isoform 1 of Chromosome 2 C2orf69 homolog OS=Bos taurus OX=9913 GN=C2H2orf69 PE=4 SV=2 CANONICAL=E1BAD1-1" }, "isoforms": [ { "isoform_ac": "E1BAD1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD1/entry", "sequence": { "sequence": "MWGFRLLRSPPLLLLLPQLGIGIAASSSHAGTMNLGSNSSGGAPCSPSAERRRQQCVQLSTVPGADPQRSNELLLLAAATAGEGPGRRDLSEDPAKEEVQPPPQHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENVATILAHRFPNSYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHSTDFGAFKHLYMLLVNAFNLSQKSLLSKKNVKDSNKDSKASNCRSTSSHTTNGCQGEKERTCEKSDESAVSFFPPSLNGASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKNIKTMYWLDGGHSGGSNTWITYPEVLKEFAQTGIIVHTHVTPYQVHDPMRSWIGKEHKKFVQILGDFGMQVTSQIHFANDAPSIENHFRVHEVF", "length": 390, "header": "tr|E1BAD1-1|E1BAD1_BOVIN Isoform 1 of Chromosome 2 C2orf69 homolog OS=Bos taurus OX=9913 GN=C2H2orf69 PE=4 SV=2 CANONICAL=E1BAD1-1" }, "locus": { "chromosome": "2", "start_pos": 88492583, "end_pos": 88480956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053405.5", "url": "https://www.ensembl.org/id/ENSBTAT00000053405.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052109.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052109.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535735", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535735", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A295-1", "protein_name": "C2orf69 homolog", "gene_name": "C2orf69", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGRCRVGAASLLWGLIGPSALGLGGSMSLCGTPAACAAGPASGGGGGGGGFSSARLSPPWLRLPEVVGAEPQRANDLLLLLPPAPRGPAPPQHHVVYFPGDVQNYYDIMSCHPENFQWEHWSFENVATILAHRFPNSFIWVVKCSRMHLHKFSCYDNFVASNMFGAPEHSTDFGAFKHLHALLVNAFRLSQNILQSQKSAHGFGKDAKVSARKSELQSVPTANGCSSTEREKDCECSNNSAMNFVIPSAVGAASFTLIGFSKGCVVLNQLLYELKEAKKDKNTDAFLKNIKAIYWLDGGHSGGSNTWVTYPEVLKELAQTGIEVHSHVTPYQVFDTMRSWIGREHEKFVRILEEFGVEINDQLHFADEVPSLDNHFRVHEVF", "length": 383 }, "evidence": [ { "id": "E1BAD1", "url": "https://omabrowser.org/oma/group/E1BAD1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3V7A7-1", "protein_name": "Similar to human chromosome 2 open reading frame 69", "gene_name": "C9h2orf69", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKGSRWLRSPALVLLLLRPLLASGDSVSRLQIQTMNPGGGARGFPEGSHRLLRFTVPGSDPERSNELLLLTAGKGDSPEQPHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENIATILARRFPNSYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHSPDFGAFKHLYMLLVNAFNLTQNSLLSQSMSVWNKDCKASNCESNSSASNGGQEKNGRTCEYADELSMSFAPLSLDGASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSVRTMYWLDGGHSGGSNTWVTYPEVLKEFAQTGITVHTHVTPYQVHDPMRSWIGKEHKKFVQILGDLGMQVTSQIHFAKETPSIENHFRVHEVF", "length": 365 }, "evidence": [ { "id": "E1BAD1", "url": "https://omabrowser.org/oma/group/E1BAD1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N8R5-1", "protein_name": "Mitochondrial protein C2orf69", "gene_name": "C2orf69", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWGFRLLRSPPLLLLLPQLGIGNASSCSQARTMNPGGSGGARCSLSAEVRRRQCLQLSTVPGADPQRSNELLLLAAAGEGLERQDLPGDPAKEEPQPPPQHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENVATILAHRFPNSYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHNTDFGAFKHLYMLLVNAFNLSQNSLSKKSLNVWNKDSIASNCRSSPSHTTNGCQGEKVRTCEKSDESAMSFYPPSLNDASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLKEFAQTGIIVHTHVTPYQVRDPMRSWIGKEHKKFVQILGDLGMQVTSQIHFTKEAPSIENHFRVHEVF", "length": 385 }, "evidence": [ { "id": "E1BAD1", "url": "https://omabrowser.org/oma/group/E1BAD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9H8-1", "protein_name": "Mitochondrial protein C2orf69 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGSRRLRSPALVLLLLRPLLASGDSASRLQTRAMNPGGGERGSPEDSHRLQRSTVPGSDPQRSNELLLLTSREGDSPEQRHHVLYFPGDVQNYHEIMTRHPENYQWENWSLENIATILARRFPNSYIWVIKCSRMHLHKFSCYDNFVKSNMFGAPEHTPDFGAFKHLYMLLVNAFNLTQNGMLFKNRSVWNKDCKASNCESNPSTSNGGQKENERTCEHVDEPSMSFPPLSLDGASFTLIGFSKGCVVLNQLLFELKEAKKDKNIDAFIKSIRTMYWLDGGHSGGSNTWVTYPEVLEEFAQTGITVHTHVTPYQVHDPMRSWIGKEHKKFVQILRDLGMQVTSQIHFAKETPSIENHFRVHEVF", "length": 365 }, "evidence": [ { "id": "E1BAD1", "url": "https://omabrowser.org/oma/group/E1BAD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BAD1", "url": "https://www.uniprot.org/uniprotkb/E1BAD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "oxidative phosphorylation", "id": "GO:0006119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006119", "evidence": [ { "database": "UniProtKB", "id": "E1BAD1", "url": "https://www.uniprot.org/uniprotkb/E1BAD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAD1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 390, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAD1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAD1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAE4-1", "uniprot_ac": "E1BAE4", "uniprot_id": "E1BAE4_BOVIN", "mass": { "chemical_mass": 49148.0, "monoisotopic_mass": 49148.0 }, "refseq": { "ac": "NP_001179186", "name": "membrane-bound ghrelin O-acyltransferase MBOAT4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179186" }, "gene_names": [ { "name": "MBOAT4", "type": "recommended", "evidence": [ { "id": "E1BAE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAE4" } ] }, { "name": "MBOAT4", "type": "synonym", "evidence": [ { "id": "NP_001179186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179186" } ] } ], "protein_names": [ { "name": "Membrane bound O-acyltransferase domain containing 4", "type": "synonym", "evidence": [ { "id": "E1BAE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAE4/entry#names_and_taxonomy" } ] }, { "name": "membrane-bound ghrelin O-acyltransferase MBOAT4", "type": "synonym", "evidence": [ { "id": "NP_001179186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179186" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAE4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MBOAT4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4", "locus": { "chromosome": "27", "start_pos": 26306486, "end_pos": 26315497, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000743", "url": "https://www.ensembl.org/id/ENSBTAG00000000743" } ] } } ], "crossref": [ { "id": "E1BAE4", "url": "https://alphafold.ebi.ac.uk/entry/E1BAE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000743", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000743", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510471", "url": "https://www.ncbi.nlm.nih.gov/gene/510471", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510471", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510471", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MDWLQLF", "url": "https://omabrowser.org/oma/group/MDWLQLF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAE4", "url": "https://www.orthodb.org/?gene=E1BAE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13906", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13906", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13906:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13906:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-422085", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422085", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179186", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAE4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDWLQLFFLDPVSLYQGAAFPFALLFNHLCVMDSFSTQARYLFLLAGGGALAVAAMGAFAVLVFIPALCTVVLIHSLGPQDVHRPTFLFQMTWQTLCHLGLHYTEYYLQEAPSTRFCITLSSLMLLTQKITSLSLDIREGKVVAPSGRIPNKNSLSEHLHAALPYLSYLLFFPALLGGPLCSFQRFQARVEGSSSLWSRHSFWALTWRALQILGLESLKVIVSGVVGVGAGLGGCRQLQCVFVLWSTAGLFKLTYYSHWLLDDALLRAAGFGSELGRSPGEEGLLPDADIWTLETTHRIALFARKWNQSTARWLRRLVFQQRRTWPLLQTFLFSAWWHGLHPGQVFGFLCWAVMVEADYLIHAFASVFISSWPMRLLYRALAWAHTQLIIAYIMLAVEARSLSSLWLLWNSYSSVFPTVYCILLLLLAKRKHKCN", "length": 435, "header": "tr|E1BAE4-1|E1BAE4_BOVIN Isoform 1 of Membrane bound O-acyltransferase domain containing 4 OS=Bos taurus OX=9913 GN=MBOAT4 PE=4 SV=3 CANONICAL=E1BAE4-1" }, "isoforms": [ { "isoform_ac": "E1BAE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAE4/entry", "sequence": { "sequence": "MDWLQLFFLDPVSLYQGAAFPFALLFNHLCVMDSFSTQARYLFLLAGGGALAVAAMGAFAVLVFIPALCTVVLIHSLGPQDVHRPTFLFQMTWQTLCHLGLHYTEYYLQEAPSTRFCITLSSLMLLTQKITSLSLDIREGKVVAPSGRIPNKNSLSEHLHAALPYLSYLLFFPALLGGPLCSFQRFQARVEGSSSLWSRHSFWALTWRALQILGLESLKVIVSGVVGVGAGLGGCRQLQCVFVLWSTAGLFKLTYYSHWLLDDALLRAAGFGSELGRSPGEEGLLPDADIWTLETTHRIALFARKWNQSTARWLRRLVFQQRRTWPLLQTFLFSAWWHGLHPGQVFGFLCWAVMVEADYLIHAFASVFISSWPMRLLYRALAWAHTQLIIAYIMLAVEARSLSSLWLLWNSYSSVFPTVYCILLLLLAKRKHKCN", "length": 435, "header": "tr|E1BAE4-1|E1BAE4_BOVIN Isoform 1 of Membrane bound O-acyltransferase domain containing 4 OS=Bos taurus OX=9913 GN=MBOAT4 PE=4 SV=3 CANONICAL=E1BAE4-1" }, "locus": { "chromosome": "27", "start_pos": 26315497, "end_pos": 26306489, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000986.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000986.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000986.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000986.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510471", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510471", "resource": "KEGG Pathway" }, { "id": "R-BTA-422085", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422085", "resource": "Reactome", "description": "Synthesis, secretion, and deacylation of Ghrelin" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7IKL6-1", "protein_name": "Ghrelin O-acyltransferase", "gene_name": "Mboat4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDWLQLFFLHPISLYQGAAFPFALLFNYLCIMDSFSTRARYLFLLAGGGVLALAAMGPYALLIFISALCAVALVSLSGPQEVHRLTFSFQMGWQTLCHLGLHYTEYYLQEPAPVRFYIALSSLMLLTQRVTSLSLDIREGKVEAASGGTRNRSSLSVCPSETLPFASYLLFFPALLGGPLCSFQRFRACVERSSSLHPCLSLWALTRRGLQIVGLECLQVALRRVVSAGAGLDDCQQLECIYIMWSTAGLFKLTYYSHWILDDALLHAAGFGSETGQRSGEEGYIPDVDLWTLETTHRISVFARQWNRSTARWLRRLIFRNSQRWPVLQTFAFSAWWHGLHPGQVFGFLCWSVMVEADYLIHTFANLSISFWPLRLLYRAFTWAHTQLIIAYIMLAVEGRSLSFLSRLCCSYNSIFPGVYCVLLFLLVKRKQKCN", "length": 435 }, "evidence": [ { "id": "E1BAE4", "url": "https://omabrowser.org/oma/group/E1BAE4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XGU5-1", "protein_name": "Membrane bound O-acyltransferase domain containing 4", "gene_name": "MBOAT4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRWADLLILLPAAWYQLAAFLFAALFHYLCALGHLSLTSRYIFLLAGGCLLAGTAMGSYATLLLIPAVSSVLMFLLVSPAYVHTWVFSLQMCWQTLCHLGLGSLVLESQDTRPAVTLSAIMLLTQKVTSLAMDIHEGTVLPQPGQGLLQRALPLCSYLLFFPALLGGPLCSFSKFQAQVMSLGAVPCPLRAVGWRYLGVLVLQVLRAWLEGWLPCMQGWASMGHMWAQALLFRLAYYSQWVLDEALLEAAGFGAAVEHRDLSGHDLWTLETTHRLSVFSRTWNRSTSLWLRRLVFQRCPVQPLLATFAFSAWWHGLRPGQIFGFLCWAIMVEADYRIHPFLSSRATSCVAKLLYRGTTWVFTQLIIAYIQMAVETESFSMLCLLWTSYNSILPLTYGLVLLLLLLFAQKPKQNRACPGLTRLAG", "length": 424 }, "evidence": [ { "id": "E1BAE4", "url": "https://omabrowser.org/oma/group/E1BAE4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B1Q005-1", "protein_name": "Membrane-bound ghrelin O-acyltransferase MBOAT4", "gene_name": "Mboat4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDWLQFFFLHPVSLYQGAAFPFALLFNYLCITESFPTRARYLFLLAGGGVLALAAMGPYALLIFIPALCAVAMISSLSPQEVHGLTFFFQMGWQTLCHLGLHYKEYYLCEPPPVRFYITLSSLMLLTQRVTSLSLDISEGKVEAAWRGTRSRSSLCEHLWDALPYISYLLFFPALLGGSLCSFQRFQACVQRPRSLYPSISFWALTWRGLQILGLECLKVALRRVVSAGAGLDDCQRLECIYIMWSTAGLFKLTYYSHWILDDSLLHAAGFGSEAGQRPGEERYVPDVDIWTLETTHRISLFARQWNRSTAQWLKRLVFQRSRRWPVLQTFAFSAWWHGLHPGQVFGFLCWSVMVKADYLIHTFANGCIRSWPLRLLYRSLTWAHTQIIIAYVMLAVEGRSFSSLCRLCCSYNSIFPVTYCLLLFLLARRKHKCN", "length": 435 }, "evidence": [ { "id": "E1BAE4", "url": "https://omabrowser.org/oma/group/E1BAE4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RX63-1", "protein_name": "Membrane bound O-acyltransferase domain containing 4", "gene_name": "MBOAT4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDWLQLFFLHPVLFYQGAAFPFALLFNYLCITDSFSTRARYLFLLAGGGALAVAAMGAFAVLVFVPALGAVVLIHSLGPRHVHRPTFLFQMSWQTLCHLGLHYTEYYLQESPSTRFCITLSSLMLLTQRVTSLSLDIFEGKVEVASEAVGSESSLPKRLWKALPYCSYLLFFPALLGGPLCSFQRFQSRVQGPRSWDPRHSLWALTCGLQILGLECLKVAMRWAVSVGAGLTDCRHLQCVYVMWSMAGLFKLTYYSHWILDESLLQAAGFGSGFGGSTGEESFVPDADIWTLETTHKLSLFTRKWNHSTAQWLRRVFQQGRTWPLLQTFVFSAWWHGLHPGQVFGFLCWAVMVKADYLIHTFAKVSIRSQLMWLLYRTLTWAHTQLIIAYIILAVEARSLSSLWLLCNSYNSVFPMVYCILFFLLAKRKHKCN", "length": 433 }, "evidence": [ { "id": "E1BAE4", "url": "https://omabrowser.org/oma/group/E1BAE4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P0C7A3-1", "protein_name": "Membrane-bound ghrelin O-acyltransferase MBOAT4", "gene_name": "Mboat4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWLQLFFLHPLSFYQGAAFPFALLFNYLCILDTFSTRARYLFLLAGGGVLAFAAMGPYSLLIFIPALCAVALVSFLSPQEVHRLTFFFQMGWQTLCHLGLHYTEYYLGEPPPVRFYITLSSLMLLTQRVTSLSLDICEGKVEAPRRGIRSKSSFSEHLWDALPHFSYLLFFPALLGGSLCSFRRFQACVQRSSSLYPSISFRALTWRGLQILGLECLKVALRSAVSAGAGLDDCQRLECIYLMWSTAWLFKLTYYSHWILDDSLLHAAGFGAEAGQGPGEEGYVPDVDIWTLETTHRISLFARQWNRSTALWLRRLVFRKSRRWPLLQTFAFSAWWHGLHPGQVFGFLCWSVMVKADYLIHTFANVCIRSWPLRLLYRALTWAHTQLIIAYIMLAVEGRSLSSLCQLCCSYNSLFPVMYGLLLFLLAERKDKRN", "length": 435 }, "evidence": [ { "id": "E1BAE4", "url": "https://omabrowser.org/oma/group/E1BAE4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96T53-1", "protein_name": "Membrane-bound ghrelin O-acyltransferase MBOAT4", "gene_name": "MBOAT4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN", "length": 435 }, "evidence": [ { "id": "E1BAE4", "url": "https://omabrowser.org/oma/group/E1BAE4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BAE4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BAE4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine O-acyltransferase activity", "id": "GO:0016412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016412", "evidence": [ { "database": "UniProtKB", "id": "E1BAE4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid modification", "id": "GO:0030258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030258", "evidence": [ { "database": "UniProtKB", "id": "E1BAE4", "url": "https://www.uniprot.org/uniprotkb/E1BAE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 435, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAE4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAF6-1", "uniprot_ac": "E1BAF6", "uniprot_id": "E1BAF6_BOVIN", "mass": { "chemical_mass": 229623.0, "monoisotopic_mass": 229623.0 }, "refseq": { "ac": "NP_001192486", "name": "protein PRRC2A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192486" }, "gene_names": [ { "name": "PRRC2A", "type": "recommended", "evidence": [ { "id": "E1BAF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAF6" } ] }, { "name": "BAT2", "type": "synonym", "evidence": [ { "id": "NP_001192486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192486" } ] }, { "name": "PRRC2A", "type": "synonym", "evidence": [ { "id": "NP_001192486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192486" } ] } ], "protein_names": [ { "name": "HLA-B associated transcript 2", "type": "synonym", "evidence": [ { "id": "NP_001192486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192486" } ] }, { "name": "Proline rich coiled-coil 2A", "type": "synonym", "evidence": [ { "id": "E1BAF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAF6/entry#names_and_taxonomy" } ] }, { "name": "protein PRRC2A", "type": "synonym", "evidence": [ { "id": "NP_001192486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192486" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAF6", "url": "https://www.uniprot.org/uniprotkb/E1BAF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRRC2A", "url": "https://www.uniprot.org/uniprotkb/E1BAF6", "locus": { "chromosome": "23", "start_pos": 27657894, "end_pos": 27671044, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019682", "url": "https://www.ensembl.org/id/ENSBTAG00000019682" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019682", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019682", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538553", "url": "https://www.ncbi.nlm.nih.gov/gene/538553", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538553", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538553", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPHIWNH", "url": "https://omabrowser.org/oma/group/TPHIWNH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAF6", "url": "https://www.orthodb.org/?gene=E1BAF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14038:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14038:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192486", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAF6", "url": "https://www.uniprot.org/uniprotkb/E1BAF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAF6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQQPESQPLPASQTPASNQSKRPPAAPENTPSVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQLSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGPEGHKESQSAGGEERPPEADGKKGNSPGSEPPPPKTAWAETSRPPETEPGPPAPKPPPPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPATPPAPAPPPAVPKELPTPPAPPPAPVPTPEKEPEESAQPSPAQSTPTPGVALAPTAVSGGGSANSTSSGSFEASAVEPQVPSKEGPEPPEEVPSPATPPAPKAEPKGDGVGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQWQQHQQGSSQPTPVPPSPPQPVTMGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAPPLLRDRGTPPVDPKLAWVGDVFTTTPADPRPLTSPLRQAADEDEKGMRSETPPVPPPPPYLASYPGFPENGAPGPPIPRFPLEEPAPPGPRPLPWPPGNEEAAKMQAPPPKKETPKEEAPQLTGPETGRKPSRGIGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEESGAPPRRAGPIKKPPPPAKVEELPPNPKPLEQGDETPKAPKPDPLKTAKGKIGGPKETPPSGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTTKEGVLTQVPLAPPSSGAPPSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPPICPGWSPPTKSLAPKKPPTGPMPPSKESLKEKLTPGPLCPMARGGSSGGNNGGMGVEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGAEGKPSSLAPPASTPGSEEALTTVAVPPPPRRAAAKSPDLSNQNSDQANEEWETASESSDFASERRGDKEAPPPALLTPKAVGTHGGSGGGAGPGISTMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPSSKSGGGGGSSGGGGGGPGGRAGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSAAAPVGHPRPKPGPPQAPQGPSPRPPTRYDPQRANNDDVNSDPHFEEPGPMVRGVSGTPRDSAGVNPFPPKRRERPPRKPELLQEESLPPSHSSGFLGPKPEGSGPQGESRDAGTEALTPHIWNRLHTATSRKSYQSGSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGSAEGPPKRPGGPSPLNAVPGEGPPGSEPSEPPRRRPPAPHDGDRKELPREQPLPPGPIGTERLQRTDRGPEPGSLRPSHRPGPPVQFGTNDKDSDLCLVVRESLKAEKELTASVTEAIPMARDWELLPSASASAEPQSKNLASGHCGPETSSSGQRLYPEIFYGSPGPPSSQVSGGAIDSQLHPNSGGFRPGTPSLHSYRSQPLYLPTGPAPPSALLSGVAVKGQFLDFSALQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDPPLLQVRQDLPSPSDFYSAPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPPLQPPSLAVRPPPAPATRVLPSPARPFGPSLGRAELHPVELKPFQDYRKLNSNLGGPGSSRTPPSGRSFSGLNSRLKAPPSTYSGVFRTQRIDLYQQASPPDALRWMPKPWERTGPPSREGPSRRAEEPGSRGDKEPGLPPPR", "length": 2166, "header": "tr|E1BAF6-1|E1BAF6_BOVIN Isoform 1 of Proline rich coiled-coil 2A OS=Bos taurus OX=9913 GN=PRRC2A PE=4 SV=3 CANONICAL=E1BAF6-1" }, "isoforms": [ { "isoform_ac": "E1BAF6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAF6/entry", "sequence": { "sequence": "MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQQPESQPLPASQTPASNQSKRPPAAPENTPSVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQLSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGPEGHKESQSAGGEERPPEADGKKGNSPGSEPPPPKTAWAETSRPPETEPGPPAPKPPPPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPATPPAPAPPPAVPKELPTPPAPPPAPVPTPEKEPEESAQPSPAQSTPTPGVALAPTAVSGGGSANSTSSGSFEASAVEPQVPSKEGPEPPEEVPSPATPPAPKAEPKGDGVGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQWQQHQQGSSQPTPVPPSPPQPVTMGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAPPLLRDRGTPPVDPKLAWVGDVFTTTPADPRPLTSPLRQAADEDEKGMRSETPPVPPPPPYLASYPGFPENGAPGPPIPRFPLEEPAPPGPRPLPWPPGNEEAAKMQAPPPKKETPKEEAPQLTGPETGRKPSRGIGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEESGAPPRRAGPIKKPPPPAKVEELPPNPKPLEQGDETPKAPKPDPLKTAKGKIGGPKETPPSGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTTKEGVLTQVPLAPPSSGAPPSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPPICPGWSPPTKSLAPKKPPTGPMPPSKESLKEKLTPGPLCPMARGGSSGGNNGGMGVEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGAEGKPSSLAPPASTPGSEEALTTVAVPPPPRRAAAKSPDLSNQNSDQANEEWETASESSDFASERRGDKEAPPPALLTPKAVGTHGGSGGGAGPGISTMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPSSKSGGGGGSSGGGGGGPGGRAGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSAAAPVGHPRPKPGPPQAPQGPSPRPPTRYDPQRANNDDVNSDPHFEEPGPMVRGVSGTPRDSAGVNPFPPKRRERPPRKPELLQEESLPPSHSSGFLGPKPEGSGPQGESRDAGTEALTPHIWNRLHTATSRKSYQSGSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGSAEGPPKRPGGPSPLNAVPGEGPPGSEPSEPPRRRPPAPHDGDRKELPREQPLPPGPIGTERLQRTDRGPEPGSLRPSHRPGPPVQFGTNDKDSDLCLVVRESLKAEKELTASVTEAIPMARDWELLPSASASAEPQSKNLASGHCGPETSSSGQRLYPEIFYGSPGPPSSQVSGGAIDSQLHPNSGGFRPGTPSLHSYRSQPLYLPTGPAPPSALLSGVAVKGQFLDFSALQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDPPLLQVRQDLPSPSDFYSAPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPPLQPPSLAVRPPPAPATRVLPSPARPFGPSLGRAELHPVELKPFQDYRKLNSNLGGPGSSRTPPSGRSFSGLNSRLKAPPSTYSGVFRTQRIDLYQQASPPDALRWMPKPWERTGPPSREGPSRRAEEPGSRGDKEPGLPPPR", "length": 2166, "header": "tr|E1BAF6-1|E1BAF6_BOVIN Isoform 1 of Proline rich coiled-coil 2A OS=Bos taurus OX=9913 GN=PRRC2A PE=4 SV=3 CANONICAL=E1BAF6-1" }, "locus": { "chromosome": "23", "start_pos": 27670978, "end_pos": 27658087, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026236.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026236.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026236.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026236.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1024, "start_aa": "Thr", "end_pos": 1024, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1024", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1288, "start_aa": "Thr", "end_pos": 1288, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1288", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 514, "start_aa": "Thr", "end_pos": 514, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr514", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 530, "start_aa": "Thr", "end_pos": 530, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr530", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 541, "start_aa": "Thr", "end_pos": 541, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr541", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 610, "start_aa": "Thr", "end_pos": 610, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr610", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 626, "start_aa": "Thr", "end_pos": 626, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr626", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538553", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538553", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8PXX5-1", "protein_name": "Protein PRRC2A isoform X1", "gene_name": "prrc2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSERSGQTAKGKDGKTKYASLNLFDTYKGKSLEAQKPVVAPRHGLQSLGKVASTRRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQADPKSTDVLSAAQPESQQPVASQTSAPSIPRTPPAQEPPTPALAVGPRSWAPASVTHGAQGDGGKGSNQPSPFSREEFPTLQAAGDQDRAGKEQATADQWYGPGPSLRPQNVTSWRDGGGRALAPTLAGEAVAEGGAGGVILMEGAAGAPPIQQQNASSHGPPRTPPTSNPALPLPQPTIGPQFQAYRGIMPPFVSMYPPYLPFPPPYGPQGPYRYPPPNEAPRFSRNQGGIGPDGRPPGGPRGEVVKRPSILKQDDLKELDELDHDGDEGWAGAQEEIDYSAKLKFSDDEGEDDGEEERGENKNGTRESREQQRSQDGPVPVSRSRASDSGGDSRRTPPSSTEDGSVSPSSKPGWAEEGGSSWNSQANAGSYQGPRPGLGGTREQPSPPPGPLLGQGPHSYYRQDRPSNQSPIPGPILAPQKPSSAHAQQQAGTVPGGPTPPPSNTLHPQQQGEDEDETWRQRRKQSSTEISAAVERARRRREEEERRMQEERRAACAEKLKRLDEKQQQQTIKPSSPSDAPANSPSPSLSAHASSPNVSQPSSPCVDTEEPPLLSAQGSGATLGLTNNNRQRAGSNSSHDSNNESQQVLQPQATQHPQSQDVPGPGDIKEEHVVGGPHIRSTRVGDDSVKVVECVGVTGRQGSGPSGQGFSKYQKSLPPRFQRQQQEQLLKQQQQWQQQQQQHNQVAAQNQLQSQPQNQQGPAPGTAPQSGPKQPTLYPPGSMGRPPPLPMNFDPRWMMMPYMDPRMMQGRPPPMDYYPPSMHPSGMMNRERSDSGGSGSDPFDRQQHAGPPHSHRGTPPMDPKLAWGPDVFPGGTEGRGLSSPLRQKAVEEEEAGKGQRSDTPPVRMREGGTASVQQPGVAPSSPSGSSNQTPPPLGIQVGGAGHHAHHQPFLDGRGGYSSYPDNGSRMGSHLQQRANSGGTLHGFGHQEGSQPNQIWGTPHPHYDRSDHSALESNSHHQHHGPPSHAPHFSLHPHKQENGREREKMVEPKKNDPSPPLHQPSLSSSCSSSSSSSSAREDGSGKQSLHNQVPPLHEHDTGSTHASGRKQDKTGNAHNQPPQHSGQQHHPRANPRNREHKTETHWGPRPGSSSVSGSSTHNRKTGSGIIAITEPSGNQGAENKSFNQSDGITVKRAGPIKRPVLKEIKREGGEGGGEKTTGGSGKDKEQDASQTTTKQEPATGNQVILAPSGKDDAVSSNKPRTGGKERGNTGGSGKGSKNGESSMQNSGYSASQSRREREHSPERGSTTYHSSSSRGSRSNRGRGEFYGRGRGYRGTYVGSAGGGNRGKAGGRNSRDYRPAANSGYHHPSSNQDYKREASSGSGRHGTSQPNPGRARNRSETRSEGSEYEEVPKRRRQRGSETGSESAGSDLAHSDKEDRKLNTKAGTVGENPTTGPSSSASVRNTQTRVFTPRGVPSRRGRGGGGAGGGLHRSGGGAGVSGGQRPGPGSSSHGWSAKSANVRKPQTSSQPPPAKDLSRGVNVDKKKPAEQNQPQSQSANPTTTVASVPTTIQQGSTENGNVGAPMSSTNAPSNPAGAPTQSLPLPAPDGRNFPNRGFERPPRRRRHGRSQHQQDKPPRFRRLKQERENAARINGSSGLIEVIAAQQQRTAPLLQNSLQQANSTPNVPDAVVANANHSVSTTPNSNNNSSNLAGGNQNFNSHHHHHYQGNSQSHPQHHHNHNPAGGAKSPDVSNQNSDQANEEWETASESSDFTEFREREGGGGGKSYSSHHHHHHHHHHPPGRGGGGGGGGDREMTAKELASGKRSFSSQRPGMERQNRRVNAGGGGGGKGQRGPPGTGGPVGGAGNGGGNRGERRGNWPSPKNRK", "length": 1923 }, "evidence": [ { "id": "E1BAF6", "url": "https://omabrowser.org/oma/group/E1BAF6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A5G2R0F0-1", "protein_name": "Proline rich coiled-coil 2A", "gene_name": "PRRC2A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPSVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPAPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHKESQAAAGEERPPEADGKKGNSPGSEPPPPKTAWAETSRPPETEPGPPAPKPPPPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAVPPAPAPPPAVPKELPTPPAPSPAPVPTPEKEPEEPAQAPPAQSTPTPGVAPAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPESPEEVPAPATPPAPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQWQQHQQGSAPPAPVPPSPPQPVTMGAVPAPQAAPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAAPLLRDRGTPPVDPKLAWVGDVFTTTATDSRPLTSPLRQATDEEDKGMRSETPPVPPPPYLASYPGFPENGAPGPPIPRFPLEEPAPPGPRPLPWPTGTDEAAKIQAPPPKKETPKEETPQLTGPEAGRKPTRGVGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPLATKVEELPPKPLEQGDETPKVPKPDTLKTAKGKIGGPKETPPSGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGVLTQVPLAPPPSGAPPSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPPICPGWSPPTKSLAPKKPPTGPLPPSKEPLKEKLLTGPLSPVARGGSSGGSNMGLGVEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGAEGKPSSLSLSTSAPGPEEALPTVAVPPPPRRAAAKSPDLSNQNSDQANEEWETASESSDFASERRGDKEAPPPALLTSKAVGTGGGGGGGGPGLSNMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPSSKASSGGGNSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERAPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGNGAAPGGHPRPKTGPSQTPQGPPPPRPPARYDPQRANSNSVTSDPHFEEPGPMVRGVGGTPQDSAGVNPFPPKRRERPPRKPELLQEESLPSSHTSGFLGPKPEGPGPQGESRDAGTEALSPHIWNRLHAAAGRKRYQPGSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAADGLPKRPGGPSPLNAVPGEGPPGSEPSEPPRRRPPAPHDGDRKELPREQPLPPGPIGTERLQRTDRGPEPSSLRSAHRPGPPVQFGTSDKDSDLCLVVGDSLKAEKELTASVTEAIPIARDWELLPSASASAEPQSKSLGSAHCGPEPSSSGQRLYPEVFYGSPGPPSSQVSGGIDSQLHPNNGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGVAVKGQFLDFSALQAAELGKLPAGGVLFPPPSFLYSPAFCPSPLPDPPLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPAARVLPSPARPFGPSLGRAELHPVELKPFQDYRKLNSNLGGPGSSRTPPAGRSFSGLNSRLKAPPSTYSGVFRTQRIDLYQQASPPDALRWMPKPWERTGPPSREGPSRRAEEPGSRGDKEPGLPPPR", "length": 2164 }, "evidence": [ { "id": "E1BAF6", "url": "https://omabrowser.org/oma/group/E1BAF6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P48634-1", "protein_name": "Protein PRRC2A", "gene_name": "PRRC2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAEEPGSRGDKEPGLPPPR", "length": 2157 }, "evidence": [ { "id": "E1BAF6", "url": "https://omabrowser.org/oma/group/E1BAF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TSC1-1", "protein_name": "Protein PRRC2A", "gene_name": "Prrc2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPTAPENTPSVPSGVKSWAQASVTHGAHGDGGRASNLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDDLEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHKDSQSAAAEEPETDGKKGTSPGSELPPPKTAWTENARPSETEPAPPTPKPPPPPPHRGPVGNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPVTPAAPALPPVVPKEIPAAPALPPTPTPTPEKEPEEPAQAPPVQAAPSPGVAPVPTLVSGGGCTANSNSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPAPKMEPKGDGVGSTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQQWQQQQQGTAPPAPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAPPLLRERGTPPVDPKLAWVGDVFTTTPTDPRPLTSPLRQAADEEEKSMRSETPPVPPPPPYLANYPGFPENGTPGPPISRFPLEESAPPGPRPLPWPPGNDEAAKMQAPPPKKEPSKEEPPQLSGPEAGRKPARGGQGPPPPRRENRTETRWGPRPGSCRRGIPPEEPGVPPRRAGPIKKPPPPVKVEELPPKSLEQGDETPKVPKPDALKTAKGKVGPKETPPGGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGSGGTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPPPKEGVLGQVPLAPPQPGAPPSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPVCSGWSPPAKSLVPKKPPTGPLPPSKEPLKEKLISGPLSPMSRAGNMGVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGADGKPPSLTLAASTPGPEETLTAATVPPPPRRTAAKSPDLSNQNSDQANEEWETASESSDFASERRGDKETPPAALMTSKAVGTPGANAGGAGPGISAMSRGDLSQRAKDLSKRSFSSQRPGMDRQNRRPGTGGKTGSGGGSSGGGGAGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGNVTAPGGHPRPKPGPPQAPQGSSPRPPTRYDPPRASSAISSDPHFEEPGPMVRGVGGTPRDSAGVNPFPPKRRERPPRKPELLQEETVPASHSSGFLGSKPEVPGPQEESRDSGTEALTPHIWNRLHTATSRKSYQPGSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGSAEGPPKRPGGPSPLNAVPGESASGSEPSEPPRRRPPASHEGERKELPREQPLPPGPIGTERSQRTDRGPEPGPLRPAHRPGSQVEFGTTNKDSDLCLVVGDTLKGEKELVASATEAVPISRDWELLPSASTSAEPQPKSLGSGQCVPEPSPSGQRPYPEVFYGSPGPPNSQQVSGGAPIDSQLHPNSGGFRPGTPSLHQYRSQPLYLPPGPAPPSALLSGVALKGQFLDFSALQATELGKLPAGGVLYPPPSFLYSAAFCPSPLPDPPLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQMLLPVVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPNLAVRPPPAPAARVLPSPARPFAPSLGRAELHPVELKPFQDYRKLSSNLGGPGSSRTPPSGRPFSGLNSRLKAPPSTYSGVFRTQRIDLYQQASPPDALRWMPKPWERAGPPSREGPPRRAEEPGSRGEKEPGLPPPR", "length": 2158 }, "evidence": [ { "id": "E1BAF6", "url": "https://omabrowser.org/oma/group/E1BAF6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BAF6", "url": "https://www.uniprot.org/uniprotkb/E1BAF6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BAF6", "url": "https://www.uniprot.org/uniprotkb/E1BAF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BAF6", "url": "https://www.uniprot.org/uniprotkb/E1BAF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1005, "end_pos": 1007, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1443, "end_pos": 1445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAF6" }, { "id": "PF07001", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAT2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 188, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 514, 530, 541, 560, 610, 626, 1024, 1288 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1005, "end_pos": 1007 }, { "start_pos": 120, "end_pos": 122 }, { "start_pos": 1443, "end_pos": 1445 }, { "start_pos": 203, "end_pos": 205 }, { "start_pos": 577, "end_pos": 579 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAH0-1", "uniprot_ac": "E1BAH0", "uniprot_id": "E1BAH0_BOVIN", "mass": { "chemical_mass": 114689.0, "monoisotopic_mass": 114689.0 }, "refseq": { "ac": "XP_024840735", "name": "GRB10-interacting GYF protein 1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840735" }, "gene_names": [ { "name": "GIGYF1", "type": "recommended", "evidence": [ { "id": "E1BAH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAH0" } ] }, { "name": "GIGYF1", "type": "synonym", "evidence": [ { "id": "XP_024840735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840735" } ] } ], "protein_names": [ { "name": "GRB10 interacting GYF protein 1", "type": "synonym", "evidence": [ { "id": "E1BAH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAH0/entry#names_and_taxonomy" } ] }, { "name": "GRB10-interacting GYF protein 1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024840735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840735" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAH0", "url": "https://www.uniprot.org/uniprotkb/E1BAH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIGYF1", "url": "https://www.uniprot.org/uniprotkb/E1BAH0", "locus": { "chromosome": "25", "start_pos": 35909566, "end_pos": 35900360, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015738", "url": "https://www.ensembl.org/id/ENSBTAG00000015738" } ] } } ], "crossref": [ { "id": "E1BAH0", "url": "https://alphafold.ebi.ac.uk/entry/E1BAH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015738", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015738", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00072", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00072", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532406", "url": "https://www.ncbi.nlm.nih.gov/gene/532406", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FHNTGEC", "url": "https://omabrowser.org/oma/group/FHNTGEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14445", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14445", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14445:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14445:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840735", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840735", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAH0", "url": "https://www.uniprot.org/uniprotkb/E1BAH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAH0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKESKVPDELQDKEFAALLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLGGASRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKSARRDGARSGFDEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGDRRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRGPDGFDDDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEEPSEGLDEEGPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGANGEGDDPVEKDLPAAEGEDMRGMQLSPGAGSPPGPPDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAIQAQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMALLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVGSSRQLPQCVLREKAALGDLPPPQQQQLTAFLQQLQALKPPRGGDQNLLPTMNRSLSVPDSGPLWDIHTSASPQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQQQEEQKRRQEEEELFRRKQARQQELLLKLLQQQQQAVAAVPAPPTPSSPPPLWAGLAKQGLSMKTLLELQLEGERHLHKQPPPREPSRAQAPNHRVQLGGLGSAPLNQWVSEAGPLWGGPDKSGGGSSSLGLWEDTLKSSGSLARSLGLKNSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTTGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSGSLQTAFQTNHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY", "length": 1036, "header": "tr|E1BAH0-1|E1BAH0_BOVIN Isoform 1 of GRB10 interacting GYF protein 1 OS=Bos taurus OX=9913 GN=GIGYF1 PE=3 SV=1 CANONICAL=E1BAH0-1" }, "isoforms": [ { "isoform_ac": "E1BAH0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAH0/entry", "sequence": { "sequence": "MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKESKVPDELQDKEFAALLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLGGASRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKSARRDGARSGFDEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGDRRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRGPDGFDDDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEEPSEGLDEEGPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGANGEGDDPVEKDLPAAEGEDMRGMQLSPGAGSPPGPPDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAIQAQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMALLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVGSSRQLPQCVLREKAALGDLPPPQQQQLTAFLQQLQALKPPRGGDQNLLPTMNRSLSVPDSGPLWDIHTSASPQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQQQEEQKRRQEEEELFRRKQARQQELLLKLLQQQQQAVAAVPAPPTPSSPPPLWAGLAKQGLSMKTLLELQLEGERHLHKQPPPREPSRAQAPNHRVQLGGLGSAPLNQWVSEAGPLWGGPDKSGGGSSSLGLWEDTLKSSGSLARSLGLKNSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTTGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSGSLQTAFQTNHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY", "length": 1036, "header": "tr|E1BAH0-1|E1BAH0_BOVIN Isoform 1 of GRB10 interacting GYF protein 1 OS=Bos taurus OX=9913 GN=GIGYF1 PE=3 SV=1 CANONICAL=E1BAH0-1" }, "locus": { "chromosome": "25", "start_pos": 35907279, "end_pos": 35900842, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076528.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076528.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056959.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 754, "start_aa": "Thr", "end_pos": 754, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr754", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HM07-1", "protein_name": "GRB10-interacting GYF protein 1 isoform X1", "gene_name": "Gigyf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAETLNFGPEWLRALSGGGNVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFTAVLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKSARRDGARSGFEEGGAGPRKEHARSDSENWRSLREEQEEDGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGACGEEDGRLGGGSSHLRRCRGLDGFEDDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEEPSEGVDEEGPEAGGKEVTPLPPPEKSSSPSPLPALGPLWTTNEDGDEVVEKEPPPAEGDEMRGLSLSPGVGSPPGPPGDLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCTTLREKAAMGDLTPPQQQQLTAFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRLCREEKRRQQQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATSVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQPAPREPLRAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGSSSGSLGLWEDTVKSGGNLARNLGLKNSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTTGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQEAWLSSTSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY", "length": 1037 }, "evidence": [ { "id": "E1BAH0", "url": "https://omabrowser.org/oma/group/E1BAH0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LD97-1", "protein_name": "GRB10 interacting GYF protein 1", "gene_name": "Gigyf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEDEQRNFSLSVNSVAVLRLMGKGAGPPLAATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKSARRDGGMRVLDVVASRVGRQPRWGSQVECGRETGVSYLEALPYLLFVSPVPVRSGFEEGGAGPRKEHARSDSENWRSLREEQEDDSSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGGCGEEDGRVGGGNSHLRRCRGLDGFEDDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEEPSDGVDEEGPEAGGKEVTPLPPSEKSSSPSSLPALGPLWTANEDGEAVEKELPPAEGDEMRGLPLSPRISSPPAGPPADLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCATLREKAAMGDLTPPQQQLTTFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRVKREEEERKRREEKRRQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATNVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQPAPREPLRAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGSSSGNLGLWEDTLKSGGSLARSLGLKNSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTTSSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQQQQQQQQQQQEAWLSSSSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY", "length": 1088 }, "evidence": [ { "id": "E1BAH0", "url": "https://omabrowser.org/oma/group/E1BAH0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75420-1", "protein_name": "GRB10-interacting GYF protein 1", "gene_name": "GIGYF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGSSGEIESVDDY", "length": 1035 }, "evidence": [ { "id": "E1BAH0", "url": "https://omabrowser.org/oma/group/E1BAH0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99MR1-1", "protein_name": "GRB10-interacting GYF protein 1", "gene_name": "Gigyf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAETLNFGPEWLRALSSGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQEEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLPATSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRNPREIQRSQSWDDRGERRFEKPARRDGVRSGFEEGGAGPRKEHARSDSENWRSLREEQEDDGSWRLGAGPRRDGDRWRSTSPDGGPRSAGWREHGERRRKFDFDLRGERGGCGEEDGRVGGGNSHLRRCRGLDGFEDDKDGLPEWCLEDEDEEMGTFDASGAFLPLKKGPKEAIPEEQELDFRGLEEEEEEEEEPSEGVDEERPEAGGKEATPLPPPENSSSPSSLPALGPLWTTNEEGGEAVEKELPPAEGDELRGLSLSPRISSPPGPPGDLEDEEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSTAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQHFLQLVGSRQLPQCTTLREKAAMGDLTPPQQQQLTTFLQQLQALKTPRGGDQNLLPTMSRSLSVPDSGPLWDLHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQQQEEQKRRQEEEELFRRKQVRQQELLLKLLQQQQATNVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQMESERQLHKQAAPREPLRAQAPNHRVQLGGLGSAPLNQWVSEAGPLWGGPDKSGGSSGGNLGLWEDTLKSGGSLARSLGLKSSRSSPSLSDSYSHLSGRPVRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSTAGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQQQQQQQQQEAWLSSTSLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGPSGEIESVDDY", "length": 1044 }, "evidence": [ { "id": "E1BAH0", "url": "https://omabrowser.org/oma/group/E1BAH0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BAH0", "url": "https://www.uniprot.org/uniprotkb/E1BAH0" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BAH0", "url": "https://www.uniprot.org/uniprotkb/E1BAH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of translational initiation", "id": "GO:0045947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045947", "evidence": [ { "database": "UniProtKB", "id": "E1BAH0", "url": "https://www.uniprot.org/uniprotkb/E1BAH0" } ], "pmid": "" }, { "name": "insulin-like growth factor receptor signaling pathway", "id": "GO:0048009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048009", "evidence": [ { "database": "UniProtKB", "id": "E1BAH0", "url": "https://www.uniprot.org/uniprotkb/E1BAH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 629, "end_pos": 631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" }, { "start_pos": 992, "end_pos": 994, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAH0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1036, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAH0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAH0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 754 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 629, "end_pos": 631 }, { "start_pos": 663, "end_pos": 665 }, { "start_pos": 89, "end_pos": 91 }, { "start_pos": 992, "end_pos": 994 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAI1-1", "uniprot_ac": "E1BAI1", "uniprot_id": "E1BAI1_BOVIN", "mass": { "chemical_mass": 51718.0, "monoisotopic_mass": 51718.0 }, "refseq": {}, "gene_names": [ { "name": "ZC2HC1C", "type": "recommended", "evidence": [ { "id": "E1BAI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAI1" } ] } ], "protein_names": [ { "name": "Zinc finger C2HC-type containing 1C", "type": "synonym", "evidence": [ { "id": "E1BAI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAI1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAI1", "url": "https://www.uniprot.org/uniprotkb/E1BAI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZC2HC1C", "url": "https://www.uniprot.org/uniprotkb/E1BAI1", "locus": { "chromosome": "10", "start_pos": 86328461, "end_pos": 86318504, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013983", "url": "https://www.ensembl.org/id/ENSBTAG00000013983" } ] } } ], "crossref": [ { "id": "E1BAI1", "url": "https://alphafold.ebi.ac.uk/entry/E1BAI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013983", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013983", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540480", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540480", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WGRSQEN", "url": "https://omabrowser.org/oma/group/WGRSQEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAI1", "url": "https://www.orthodb.org/?gene=E1BAI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14649", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14649", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14649:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14649:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13913", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13913", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BAI1", "url": "https://www.uniprot.org/uniprotkb/E1BAI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLQLVLPLPMGVMLPHNKRDSPELHSAKQDPYRKGDSSQRSSTGHPRNNFQQKLWSNQELMLDNLYTHPKWNTCTKAQSCSYPHCAGMSQHDSRSNPQGQAKGLFYTSDPQCQYPKTNDQEFIPLTKKRVGVDRAYPLKPVFHRKSHSTGEAGTDGDQNAFPRTPEPRKYSYSSFGSRNWVNSSMVGPVAATQEERVMANANRTEWMQIQRLEAAGESLGEEIRRKETLLREKLKKTEEKLRRIQKGKEQAEENEKRQLQRMVLSRRRVKDNSITTYKPIFSPALGSEEVFSRDTGEDETWGQSQENSSPFQFSNYRIQKLKRERLVASNNKIRDRVSRPLKEKFSQATEAPLNALQRYTSNSSSSRAPDSSGSSCSTEEPELGECSHCGRKFLLLRLERHSSICRRMQGSKRKVFDSSRARAKGTELEQYLNWKGPASVKVTRALWICH", "length": 452, "header": "tr|E1BAI1-1|E1BAI1_BOVIN Isoform 1 of Zinc finger C2HC-type containing 1C OS=Bos taurus OX=9913 GN=ZC2HC1C PE=3 SV=3 CANONICAL=E1BAI1-1" }, "isoforms": [ { "isoform_ac": "E1BAI1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI1/entry", "sequence": { "sequence": "MAGLQLVLPLPMGVMLPHNKRDSPELHSAKQDPYRKGDSSQRSSTGHPRNNFQQKLWSNQELMLDNLYTHPKWNTCTKAQSCSYPHCAGMSQHDSRSNPQGQAKGLFYTSDPQCQYPKTNDQEFIPLTKKRVGVDRAYPLKPVFHRKSHSTGEAGTDGDQNAFPRTPEPRKYSYSSFGSRNWVNSSMVGPVAATQEERVMANANRTEWMQIQRLEAAGESLGEEIRRKETLLREKLKKTEEKLRRIQKGKEQAEENEKRQLQRMVLSRRRVKDNSITTYKPIFSPALGSEEVFSRDTGEDETWGQSQENSSPFQFSNYRIQKLKRERLVASNNKIRDRVSRPLKEKFSQATEAPLNALQRYTSNSSSSRAPDSSGSSCSTEEPELGECSHCGRKFLLLRLERHSSICRRMQGSKRKVFDSSRARAKGTELEQYLNWKGPASVKVTRALWICH", "length": 452, "header": "tr|E1BAI1-1|E1BAI1_BOVIN Isoform 1 of Zinc finger C2HC-type containing 1C OS=Bos taurus OX=9913 GN=ZC2HC1C PE=3 SV=3 CANONICAL=E1BAI1-1" }, "locus": { "chromosome": "10", "start_pos": 86320822, "end_pos": 86319467, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018587.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018587.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018587.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018587.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540480", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540480", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NAH9-1", "protein_name": "Zinc finger C2HC-type containing 1C", "gene_name": "ZC2HC1C", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAELQVALFPYVDPVVAAAKLPVTDSYDSEVSVHQYPLEHLKNSCQREFLSDKEEGLKNPLARKSRSYSYSLSAESNKHSSQHGGSSSAGLQNKHLASQVKTLPSKSVAKRKEGVDRSCPLKPIFHHNTGSLPAVNTGQLGSSPNMEEALNSKTSSKSKGRHLPGKPQLAAVLPPWTAEPKQSDSSLYRRDLAYILRLEADGQTLEKEIRKKEALLREKLRRTKEELRRIQREKELMEAEERRARAVERTRRQKAVWQPGEENIRFTIRMDDGDFSGVQSAEVTVPKTGTTLHPQELAMGKLKKERLVASNNKIRDRIPVEDLASCSELALKHGPSSSALSDCGDRLPAEMLYMQAASPTEQGELGKCSFCGRKFLCARLKKHMSICSKSQGSKRKTFDSSKARARGTDLEEFQQWKSSERPQNKPPRRNNWRQNHEAFIQTLRHARQVQQVLSKGGKVSDLPPLPPIENPDYTACPYCRRRFAPQVAETHIPKCKNIKNRPSLPPQRKR", "length": 510 }, "evidence": [ { "id": "E1BAI1", "url": "https://omabrowser.org/oma/group/E1BAI1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S2Q5-1", "protein_name": "Zinc finger C2HC-type containing 1C", "gene_name": "ZC2HC1C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGLQLALTLPVGIMFPYNKREAPELHSVKQDPYEKGDSSQRSSMGHLRNNFQQELLSNKELTLDKLYTHPKWNTSMKAWSCSYPHCAEISQQDSRKGLFYSSGPQSQYPKANIQEFIPFTKKRVGVDRAYPLKPVFHRKSRSTGEAGTDGDQNVSLRSHQPRKLSYSSFGSRNWVNSSVVGSVAATQEERVVANPSRMEWMQIQRLEAAGESLEEEIRRKETLLREKLKKTEEELRRIQKKKEQAEENEKRELQRRMALPRRRVKGKSNTSHKPIFSPEFKSAEVFSRDVGDDETWGRSQENSSPFQFSDHGIQKLKREGLMASNNQIRDRVSGPLKEKFSQASEMPPSALQRSTCHSSLSRAPDSLGSSCSTEEPELGACSHCGRKFLLLRLERHSNVCSRMRGSKRKVFDSSRARAKGTELEQYLNWKGSASVKAEPPRKSNWRQKHESFIRTLRQARQIQHVIAKGGNPSDLPPILPAENPDYIQCPHCSRHFAPKVAERHIPKCKTIKSRPPPPRKYDS", "length": 524 }, "evidence": [ { "id": "E1BAI1", "url": "https://omabrowser.org/oma/group/E1BAI1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HFQ9-1", "protein_name": "Zinc finger C2HC domain-containing protein 1C", "gene_name": "Zc2hc1c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGLQLAPHLPVGVMFPHSKTEAPGLHSAKHDPYEQRDSSQRSSVGHLRNNFQQKHWSNTELEQEEGVSTYPQRNICAKARRHSCPHSARISQRSPGSNPQGQGKALSSLSSPPPRYHKANDQDFIPFRKKRIGVDRAYPLKPMVHRKSLSTGEAGTGDGDQNVYPRLPEFSDSNFGLRSWVNSSILASVQAEEVMADLHRTRPEWTQIQRLEAAGETLQREIRRKETLLREKLKKTEEGLRRIQKEKKQAQQNEDRELPRMMPAGRVRESGCNAALSPEFSSEMLSRNRREAQPCERAQEDSSPLQFSDYEIQRLKRERLMASNRKVRDSATPAEEFSKPSEELGSTPQASSLSGTPASSESSSSTEEPELGKCSYCGRTFLWLRLQRHSAVCGKMQGSRRKVFDSSRARAKGTELEQFLNWKGPATAKTEPPRKSTWRQKHESFIRTLRHARQVQQVIAKGGNPSDLPPVLPAENPDYVQCLHCSRHFAPKVAERHIPKCKTIKNRPPPPRRYDS", "length": 517 }, "evidence": [ { "id": "E1BAI1", "url": "https://omabrowser.org/oma/group/E1BAI1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q53FD0-1", "protein_name": "Zinc finger C2HC domain-containing protein 1C", "gene_name": "ZC2HC1C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLQRLASHLPVGVMLPHNTTEAPGPHSAKQDSYEQGDSSQQSLKGHLRNNFQKQLLSNKELILDKVYTHPKWNTQTKARSYSYPHCTGISQQDPESDSQGQGNGLFYSSGPQSWYPKANNQDFIPFTKKRVGVDRAFPLKPMVHRKSCSTGEAGTDGDHNVYPRPPEPREFSSRNFGVRNQGNFSVVGTVLAATQAEKAVANFDRTEWVQIRRLEAAGESLEEEIRRKQILLRGKLKKTEEELRRIQTQKEQAKENENGELQKIILPRSRVKGNKSNTMYKPIFSPEFEFEEEFSRDRREDETWGRSQQNSGPFQFSDYRIQRLKRERLVASNNKIRDPVSEPSVEKFSPPSETPVGALQGSARNSSLSMAPDSSGSSGSIEEPQLGECSHCGRKFLSFRLERHSNICSRMRGSKRKVFDSSRARAKGTELEQYLNWKGPASAKAEPPQKSNWR", "length": 456 }, "evidence": [ { "id": "E1BAI1", "url": "https://omabrowser.org/oma/group/E1BAI1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AYP4-1", "protein_name": "Zinc finger C2HC domain-containing protein 1C", "gene_name": "Zc2hc1c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGLQLAPHLPVGVMFPHNKTEAHGLHSAKHDPYEQSDSPQRSSMGHLRTSFQQKLWSNTELEQEDVISTHPKRNICTKARRHSCPHSAGISQQGSGNNAQGQGKGLFYLSSPTPRYPKANDQDFIPFRKKRVGVDRAYPLKPMVHRKSHSTSETGIDGDQNGYPRLPDSSEFSDSSFGLRSWVNPSLLASPQAEKVMAQLHRTEWTQIQRLEAAGESLQKEIRRKEILLREKLKKTEEGLRRIQREKKQAIFQEDRELQRMVLPRRRVRDGDLDTTHNSCLSPELRSEVFSRNRGEDQTCEQAQENSSPLQLSDYEIQRLKRERLMVSNNKIRDRDSGPSAGTFSQPAEDLGDELQASSLSGTPGSSGSSSSTEEQELGKCSHCGRSFLSLRLQRHSTVCGKMQGSKRKVFDSSRARAKGTELEQYLNWRGPATDKAEPPPRKSTWRQKHESFIRTLRHARQVQQVIARGGNPSDLPSILPAENPDYVQCPHCSRHFAPKVAERHIPKCKTIKNRPPPPRRHDS", "length": 525 }, "evidence": [ { "id": "E1BAI1", "url": "https://omabrowser.org/oma/group/E1BAI1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CCG1-1", "protein_name": "Zinc finger C2HC domain-containing protein 1C", "gene_name": "Zc2hc1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGLQLAPHLPVGVMFPHNKTEAPGLHSAKHDPYEQSDSSQRPSMGHLRNSFQSKLWSNTEMEQEDEVSTRPKRNVCTKARRHSCPHSAGIRQQGSGNNAQGQGKGLFYLSSPTPRYPKANDQDFIPFRRKRVGVDRAYPLKPMVHRKSHSTSDAGADGDQNGYPRLPDSSEFSDNSFGLRSWVNSSLLASVQAEKVVAELHRTEWTQIQRLEAAGESLQKEIRRKEILLQEKLKKTEEGLRRMQKEKKQAIFQEDRELQRMVLPRRRVRDGDHDTPHKPCLSPEFRSEVFSRNRGEDQTCDQAQENPSPRQLSDYELQKLKRERLMASNSKIRDQDAGPSADAFFQPAEELGSTLQESSRSGTPGSSGSSSSTEEPELAKCSHCGRSFLSLRLQRHSTVCGKMQGSKRKVFDSSRARAKGTELEQYLNWRGPATAKAETPPPPRKSTWRQKHESFIRTLRHARQVQQVIARGGNPSDLPSILPADNPDYVQCPHCSRHFAPKVAERHIPKCKTIKNRPPPPRRHDS", "length": 527 }, "evidence": [ { "id": "E1BAI1", "url": "https://omabrowser.org/oma/group/E1BAI1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAI1", "url": "https://www.uniprot.org/uniprotkb/E1BAI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAI1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 452, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAI1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAI1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAI1" }, { "id": "PS52027", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52027" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2HC/C3H-type", "eco_id": "ECO_0000259", "start_pos": 384, "end_pos": 413, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 309, "end_pos": 311 }, { "start_pos": 364, "end_pos": 366 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAP4-1", "uniprot_ac": "E1BAP4", "uniprot_id": "E1BAP4_BOVIN", "mass": { "chemical_mass": 40061.0, "monoisotopic_mass": 40061.0 }, "refseq": { "ac": "NP_001192735", "name": "STEAP1 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192735" }, "gene_names": [ { "name": "STEAP1", "type": "recommended", "evidence": [ { "id": "E1BAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP4" } ] }, { "name": "STEAP1", "type": "synonym", "evidence": [ { "id": "NP_001192735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192735" } ] } ], "protein_names": [ { "name": "STEAP family member 1", "type": "synonym", "evidence": [ { "id": "E1BAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP4/entry#names_and_taxonomy" } ] }, { "name": "STEAP1 protein", "type": "synonym", "evidence": [ { "id": "NP_001192735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192735" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAP4", "url": "https://www.uniprot.org/uniprotkb/E1BAP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STEAP1", "url": "https://www.uniprot.org/uniprotkb/E1BAP4", "locus": { "chromosome": "4", "start_pos": 74368427, "end_pos": 74361419, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015749", "url": "https://www.ensembl.org/id/ENSBTAG00000015749" } ] } } ], "crossref": [ { "id": "E1BAP4", "url": "https://alphafold.ebi.ac.uk/entry/E1BAP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015749", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015749", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515156", "url": "https://www.ncbi.nlm.nih.gov/gene/515156", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515156", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515156", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQFIWYT", "url": "https://omabrowser.org/oma/group/KQFIWYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAP4", "url": "https://www.orthodb.org/?gene=E1BAP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14239:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14239:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192735", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAP4", "url": "https://www.uniprot.org/uniprotkb/E1BAP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESRQDITNQEELWKMKPRRNLEEDDYLNKDSEEIGMLKRHVLLHLHQTTHFDEFDCPPELQQKQKLFPKWRLPIKIAAIVSSLTFLYTLVREIIHPFVTSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAVVQLHNGTKYKKFPHWLDRWMVTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYRLLNWAYQQVQQNNENAWIEHDVWRMEIYVSLGIVALAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWVDIKQFIWHTPPTFMIAVFLPIVVLICKVILLLPCLRKKILKIRHGWEDVTKINKTEMSSQL", "length": 339, "header": "tr|E1BAP4-1|E1BAP4_BOVIN Isoform 1 of STEAP family member 1 OS=Bos taurus OX=9913 GN=STEAP1 PE=3 SV=1 CANONICAL=E1BAP4-1" }, "isoforms": [ { "isoform_ac": "E1BAP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAP4/entry", "sequence": { "sequence": "MESRQDITNQEELWKMKPRRNLEEDDYLNKDSEEIGMLKRHVLLHLHQTTHFDEFDCPPELQQKQKLFPKWRLPIKIAAIVSSLTFLYTLVREIIHPFVTSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAVVQLHNGTKYKKFPHWLDRWMVTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYRLLNWAYQQVQQNNENAWIEHDVWRMEIYVSLGIVALAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWVDIKQFIWHTPPTFMIAVFLPIVVLICKVILLLPCLRKKILKIRHGWEDVTKINKTEMSSQL", "length": 339, "header": "tr|E1BAP4-1|E1BAP4_BOVIN Isoform 1 of STEAP family member 1 OS=Bos taurus OX=9913 GN=STEAP1 PE=3 SV=1 CANONICAL=E1BAP4-1" }, "locus": { "chromosome": "4", "start_pos": 74368325, "end_pos": 74361451, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020911.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020911.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020911.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020911.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515156", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515156", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XDA9-1", "protein_name": "STEAP family member 1", "gene_name": "STEAP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEKREGDSHAIDQNAFQNIIPRRNRENLNNLNVDMQVANPPEVAALFNLHQAHHFSEFEYSSEQHYKQDLFPRWHMPLKIASVISLLTFIYTSLRDVIYPFIARNENVFYKIPILVINKVLPVVSITLLALVYLPGILAAGFQLYFGTKYKRFPLWLDRWMLSRKQFGLLSFFFAVMHACYSLCYPMRRSYRYKLLNWAFQQVKQKKENAWIEHDVWRMEIYVSLGILGLALLALLAIASIPSVSHSLTWREFHFIQSKMGYVALLLCTVHALVFAWNKWVDVNQFIWYTPPSFMVAVFLPIVVLLCKCILFLPCFRRRIKKIRCGWEANTQTNQTNLTSRL", "length": 342 }, "evidence": [ { "id": "E1BAP4", "url": "https://omabrowser.org/oma/group/E1BAP4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZEK7-1", "protein_name": "STEAP family member 1", "gene_name": "Steap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEISKNITNPEELWKMKPKGNLEDDSYSTKDTGETSMLKRPVLSPLPHTVHVDAFDCPTELQHTQELFPNWQLPIKVAAVLSSLTFLYTLLREIIYPLVASREQYFYKIPILVVNKVLPMVSITLLALVYLPGEIAAVVQLRNGTKYKKFPPWLDRWMLARKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYKQVQQSKEDAWVEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHASIFAWNKWVDISQFVWYMPPTFMIAVFLPTVVLICKIVLCLPCLRKKILKIRCGWEDVRKVNRTEMACRL", "length": 339 }, "evidence": [ { "id": "E1BAP4", "url": "https://omabrowser.org/oma/group/E1BAP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HL78-1", "protein_name": "Metalloreductase STEAP1", "gene_name": "Steap1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MENIKDITNQEELWKMKPKRSLEDDSYSTKHTGDPHMLKRPMLLHLQHTVHVNAFDCPSELQHTQEFFPNWRLPIKIAAVISSLTFLYTVLREIIHPLVTSHEQYFYRIPILVINKVLPMVSITLLALVYLPGVIAAVVQLRNGTKYKKFPPWLDRWMLTRKQFGLLSFFFAVLHAVYSLSYPMRRSYRYKLLNWAYKQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHALIFAWNKWVDINQFVWYMPPTFMIAVLLPTVVLICKVVLSLPCLRRKILKIRCGWEDPSKVNRMEAASRL", "length": 339 }, "evidence": [ { "id": "E1BAP4", "url": "https://omabrowser.org/oma/group/E1BAP4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9CWR7-1", "protein_name": "STEAP1 protein", "gene_name": "Steap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEISDDVTNPEQLWKMKPKGNLEDDSYSTKDSGETSMLKRPGLSHLQHAVHVDAFDCPSELQHTQEFFPNWRLPVKVAAIISSLTFLYTLLREIIYPLVTSREQYFYKIPILVINKVLPMVAITLLALVYLPGELAAVVQLRNGTKYKKFPPWLDRWMLARKQFGLLSFFFAVLHAVYSLSYPMRRSYRYKLLNWAYKQVQQNKEDAWVEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHALVFAWNKWVDVSQFVWYMPPTFMIAVFLPTLVLICKIALCLPCLRKKILKIRCGWEDVSKINRTEMASRL", "length": 339 }, "evidence": [ { "id": "E1BAP4", "url": "https://omabrowser.org/oma/group/E1BAP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GL50-1", "protein_name": "STEAP1 protein", "gene_name": "STEAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESRQDITNQEELWKMKPRKNLEDDYLNEDSRENSMPKRPMLVHLHQTAHFDEFDCPPELQHKQELFPKWHLPIKIAAIVSSLTFLYTLLREVIHPFVTSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDRWMVTRKQFGLLSFFFAVLHAVYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVTLAILALLAVTSIPSVSDSLTWREFHYIQSTLGIVSLLLGTIHALIFAWNKWVDIKQFIWYTPPTFMIAVFLPTVVLICKVILLLPCLRRKILKIRHGWEDVTKINKTEMSSQL", "length": 338 }, "evidence": [ { "id": "E1BAP4", "url": "https://omabrowser.org/oma/group/E1BAP4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9UHE8-1", "protein_name": "STEAP1 protein", "gene_name": "STEAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL", "length": 339 }, "evidence": [ { "id": "E1BAP4", "url": "https://omabrowser.org/oma/group/E1BAP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "E1BAP4", "url": "https://www.uniprot.org/uniprotkb/E1BAP4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAP4", "url": "https://www.uniprot.org/uniprotkb/E1BAP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAP4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 339, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAP4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAP4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP4" }, { "id": "PF01794", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01794" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ferric oxidoreductase", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 255, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 331, "end_pos": 333 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAQ3-1", "uniprot_ac": "E1BAQ3", "uniprot_id": "E1BAQ3_BOVIN", "mass": { "chemical_mass": 33069.0, "monoisotopic_mass": 33069.0 }, "refseq": {}, "gene_names": [ { "name": "MUC13", "type": "recommended", "evidence": [ { "id": "E1BAQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3" } ] } ], "protein_names": [ { "name": "Mucin 13, cell surface associated", "type": "synonym", "evidence": [ { "id": "E1BAQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAQ3", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MUC13", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3", "locus": { "chromosome": "1", "start_pos": 69332534, "end_pos": 69366643, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010382", "url": "https://www.ensembl.org/id/ENSBTAG00000010382" } ] } } ], "crossref": [ { "id": "E1BAQ3", "url": "https://alphafold.ebi.ac.uk/entry/E1BAQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010382", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010382", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24037:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24037:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BAQ3", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAQ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "NKGKIFPGTIKVKISYTSELENKASEAYQNLYIQVTTFFKDTFNNSEYGQTVIVKVSASTSARSEMRAGNQGVDVAVVNIFTESTKENETTISNAITKAINAPSSNFSGYDQQDQCDYYGCKKPNDQNYCDNGLLCECKDGLVRPKPQMPMCVAMCSDTCNAQSKRQCLVKSNGTADCICLPGYKEDKQGICQECPFGYSGINCEDSFQLILTIVGTIAGIVILGMVIALIVSMRLKNKGMNVEEETLIEKDSRNLRLKETGFSNLGAEGSIFPKIKVNLPRDNQPENPYTRHIPRPDY", "length": 299, "header": "tr|E1BAQ3-1|E1BAQ3_BOVIN Isoform 1 of Mucin 13, cell surface associated OS=Bos taurus OX=9913 GN=MUC13 PE=4 SV=4 CANONICAL=E1BAQ3-1" }, "isoforms": [ { "isoform_ac": "E1BAQ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3/entry", "sequence": { "sequence": "NKGKIFPGTIKVKISYTSELENKASEAYQNLYIQVTTFFKDTFNNSEYGQTVIVKVSASTSARSEMRAGNQGVDVAVVNIFTESTKENETTISNAITKAINAPSSNFSGYDQQDQCDYYGCKKPNDQNYCDNGLLCECKDGLVRPKPQMPMCVAMCSDTCNAQSKRQCLVKSNGTADCICLPGYKEDKQGICQECPFGYSGINCEDSFQLILTIVGTIAGIVILGMVIALIVSMRLKNKGMNVEEETLIEKDSRNLRLKETGFSNLGAEGSIFPKIKVNLPRDNQPENPYTRHIPRPDY", "length": 299, "header": "tr|E1BAQ3-1|E1BAQ3_BOVIN Isoform 1 of Mucin 13, cell surface associated OS=Bos taurus OX=9913 GN=MUC13 PE=4 SV=4 CANONICAL=E1BAQ3-1" }, "locus": { "chromosome": "1", "start_pos": 69349775, "end_pos": 69332537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013702.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013702.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013702.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013702.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ3", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAQ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 299, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAQ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAQ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ3" }, { "id": "PS50024", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEA", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 126, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAR0-1", "uniprot_ac": "E1BAR0", "uniprot_id": "SMIM5_BOVIN", "mass": { "chemical_mass": 8756.0, "monoisotopic_mass": 8756.0 }, "refseq": { "ac": "NP_001156472", "name": "small integral membrane protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156472" }, "gene_names": [ { "name": "SMIM5", "type": "recommended", "evidence": [ { "id": "E1BAR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAR0" } ] }, { "name": "C19H17orf109", "type": "synonym", "evidence": [ { "id": "NP_001156472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156472" } ] }, { "name": "SMIM5", "type": "synonym", "evidence": [ { "id": "NP_001156472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156472" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 5", "type": "recommended", "evidence": [ { "id": "E1BAR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAR0/entry#names_and_taxonomy" } ] }, { "name": "small integral membrane protein 5", "type": "synonym", "evidence": [ { "id": "NP_001156472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156472" } ] }, { "name": "uncharacterized protein C17orf109 homolog", "type": "synonym", "evidence": [ { "id": "NP_001156472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156472" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAR0", "url": "https://www.uniprot.org/uniprotkb/E1BAR0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM5", "url": "https://www.uniprot.org/uniprotkb/E1BAR0", "locus": { "chromosome": "19", "start_pos": 55932583, "end_pos": 55939531, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010758", "url": "https://www.ensembl.org/id/ENSBTAG00000010758" } ] } } ], "crossref": [ { "id": "E1BAR0", "url": "https://alphafold.ebi.ac.uk/entry/E1BAR0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010758", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010758", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20254", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20254", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100302388", "url": "https://www.ncbi.nlm.nih.gov/gene/100302388", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100302388", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100302388", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HCCCCGK", "url": "https://omabrowser.org/oma/group/HCCCCGK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAR0", "url": "https://www.orthodb.org/?gene=E1BAR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37344:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37344:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001156472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156472", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAR0", "url": "https://www.uniprot.org/uniprotkb/E1BAR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAR0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASKLMQEIHSIGDRLLLKLQRLPQAEPVEILAFSVLVVFTATVVLLLLIACGFCCCQYCWPRRRGRRTQVGPMTPP", "length": 78, "header": "sp|E1BAR0-1|SMIM5_BOVIN Isoform 1 of Small integral membrane protein 5 OS=Bos taurus OX=9913 GN=SMIM5 PE=4 SV=1 CANONICAL=E1BAR0-1" }, "isoforms": [ { "isoform_ac": "E1BAR0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAR0/entry#E1BAR0-1", "sequence": { "sequence": "MAASKLMQEIHSIGDRLLLKLQRLPQAEPVEILAFSVLVVFTATVVLLLLIACGFCCCQYCWPRRRGRRTQVGPMTPP", "length": 78, "header": "sp|E1BAR0-1|SMIM5_BOVIN Isoform 1 of Small integral membrane protein 5 OS=Bos taurus OX=9913 GN=SMIM5 PE=4 SV=1 CANONICAL=E1BAR0-1" }, "locus": { "chromosome": "19", "start_pos": 55933768, "end_pos": 55933092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014245.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014245.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014245.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014245.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 76, "start_aa": "Thr", "end_pos": 76, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr76", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100302388", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100302388", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNH1-1", "protein_name": "Small integral membrane protein 5", "gene_name": "SMIM5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTAADFVQEMHSVWERLLLKLQRLPQAEPVEIATFSVLVIFAATVVLLLLVAICYCCVQCCCPDRRGRKVQVRPMTPLQGTRR", "length": 83 }, "evidence": [ { "id": "E1BAR0", "url": "https://omabrowser.org/oma/group/E1BAR0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7KB90-1", "protein_name": "Small integral membrane protein 5", "gene_name": "Smim5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAATDFEEEIRSVTERLLLKLRGLPQADPVEVVAFSIIILFTATVLLLMLLACSYCCVHCCCPERRARKVAVMTIRTR", "length": 78 }, "evidence": [ { "id": "E1BAR0", "url": "https://omabrowser.org/oma/group/E1BAR0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C7Q5-1", "protein_name": "Small integral membrane protein 5", "gene_name": "SMIM5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSEAFLKEMQTIGEKLLLKLQKLPKADPVEIVSFCVVLLFIVTVLVLMIIACSCCCYSCCSCNEGPDHRRRKAQVRPTAHP", "length": 82 }, "evidence": [ { "id": "E1BAR0", "url": "https://omabrowser.org/oma/group/E1BAR0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "M0R3V6-1", "protein_name": "Small integral membrane protein 5", "gene_name": "Smim5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVTDFVEEIRSVGERLLLKLKELPQAEPVELVAFSIIVLFTATVLMLLLIACSWCCAHCCCSEGRDRKIPVRPRKPR", "length": 78 }, "evidence": [ { "id": "E1BAR0", "url": "https://omabrowser.org/oma/group/E1BAR0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q71RC9-1", "protein_name": "Small integral membrane protein 5", "gene_name": "SMIM5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATDFVQEMRAVGERLLLKLQRLPQAEPVEIVAFSVIILFTATVLLLLLIACSCCCTHCCCPERRGRKVQVQPTPP", "length": 77 }, "evidence": [ { "id": "E1BAR0", "url": "https://omabrowser.org/oma/group/E1BAR0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BT42-1", "protein_name": "Small integral membrane protein 5", "gene_name": "Smim5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATDFVGEIRSVGERLLLKLQQLPQAEPVELVAFSIIVLFTATVLVLGLIACSCCCAHCCCSESRQRKIPVRPTKPR", "length": 78 }, "evidence": [ { "id": "E1BAR0", "url": "https://omabrowser.org/oma/group/E1BAR0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BAR0", "url": "https://www.uniprot.org/uniprotkb/E1BAR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAR0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 78, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAR0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAR0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 76 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAS8-1", "uniprot_ac": "E1BAS8", "uniprot_id": "E1BAS8_BOVIN", "mass": { "chemical_mass": 121376.0, "monoisotopic_mass": 121376.0 }, "refseq": {}, "gene_names": [ { "name": "UBN1", "type": "recommended", "evidence": [ { "id": "E1BAS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ] } ], "protein_names": [ { "name": "Ubinuclein 1", "type": "synonym", "evidence": [ { "id": "E1BAS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBN1", "url": "https://www.uniprot.org/uniprotkb/E1BAS8", "locus": { "chromosome": "25", "start_pos": 3946837, "end_pos": 3915310, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001736", "url": "https://www.ensembl.org/id/ENSBTAG00000001736" } ] } } ], "crossref": [ { "id": "E1BAS8", "url": "https://alphafold.ebi.ac.uk/entry/E1BAS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001736", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001736", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR014840", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014840", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAS8", "url": "https://www.orthodb.org/?gene=E1BAS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21669", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21669", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21669:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21669:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14075", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14075", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559584", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAS8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEPHRVQFTSLPGSLNPAFLKKSRKEEVGGAEQHQDSEPAAAAVRITLTLFEPDHKRCPEFFYPELVKNLRGKVKGLQPADKKDLLDPFNDEEKERHKVEALARKFEEKYGGKKRRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFIKEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYSGALSVKEMLKKFQKEKEAQRKRDEEHKPIAVSSAEAQGLRELEGASDPLLSLFGSASDNDLLQAATAMDSLTDLDLEQLLSESPEGSPFRDMDDESDSLGVGLDQEFRQPSSLPEGLPAPLEKRVKELAQAARAAEGESRQKFFTHDVNGILLDIEAQTRELSSQTRSGVYAYLASFLPCSKDTLVKRARKLHLCEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLEEEKDKEQRERVCSDEEEDEEKGGRRIMGPRKKFQWSDEIRELLCQVVKIKLESFDLEKNKAQSWEDYVKAFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSILAKKKVMASCKMKVKESSAKPDKKVSVSSGQTGSPLALPSEHLGGGLGVGAASREPSSQASGSLAHPAPINLEDSLDGDLVHNSASSLEAVSKELAVLHSRAGGSSEFPLPTPVKVPAEKLAGVLCPEEKRNFPKPSPSSAPPPSSSLQSPLNFLAEQALALGQSSQEKKTESSGYKELSCQAALGKGPPEGQQPKAKHHGLPRTSHVPPAGTAVPDPQVKVFHAGTQPQKSFTPPAPFVNKLQGPKPGSPQCHRSLLQLVKTATKSQSFHASMPASSGTPASSSSSHKTPASCSAAVSHPAKPHSASSSGPPYKTSPFLGSASKHGVSSGSPSSGGTPVQSPASGNLLPTTQPPSTGQSTSRPVPGPAVKKPPVPQKLTLVAPPGGPNGDSSGGTQGVAKLLTSSLKPSAVSSVTSSTSLPKGASGAVLLTGSSSLNLLSSSYKAGSPKLPGALNSSPLGIISQLPLHVISFSADSSAKAGVSKDAIVTGPAPGTFHHGLGHSLLAGVHSSPPRAAPLPHTAVSTHLPQSLPDASQLHGKGPSVPRKL", "length": 1132, "header": "tr|E1BAS8-1|E1BAS8_BOVIN Isoform 1 of Ubinuclein 1 OS=Bos taurus OX=9913 GN=UBN1 PE=3 SV=4 CANONICAL=E1BAS8-1" }, "isoforms": [ { "isoform_ac": "E1BAS8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAS8/entry", "sequence": { "sequence": "MSEPHRVQFTSLPGSLNPAFLKKSRKEEVGGAEQHQDSEPAAAAVRITLTLFEPDHKRCPEFFYPELVKNLRGKVKGLQPADKKDLLDPFNDEEKERHKVEALARKFEEKYGGKKRRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFIKEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYSGALSVKEMLKKFQKEKEAQRKRDEEHKPIAVSSAEAQGLRELEGASDPLLSLFGSASDNDLLQAATAMDSLTDLDLEQLLSESPEGSPFRDMDDESDSLGVGLDQEFRQPSSLPEGLPAPLEKRVKELAQAARAAEGESRQKFFTHDVNGILLDIEAQTRELSSQTRSGVYAYLASFLPCSKDTLVKRARKLHLCEQGGRLKEPLQKLKEAIGRAMPEQMAKYQDECQAHTQAKVAKMLEEEKDKEQRERVCSDEEEDEEKGGRRIMGPRKKFQWSDEIRELLCQVVKIKLESFDLEKNKAQSWEDYVKAFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSILAKKKVMASCKMKVKESSAKPDKKVSVSSGQTGSPLALPSEHLGGGLGVGAASREPSSQASGSLAHPAPINLEDSLDGDLVHNSASSLEAVSKELAVLHSRAGGSSEFPLPTPVKVPAEKLAGVLCPEEKRNFPKPSPSSAPPPSSSLQSPLNFLAEQALALGQSSQEKKTESSGYKELSCQAALGKGPPEGQQPKAKHHGLPRTSHVPPAGTAVPDPQVKVFHAGTQPQKSFTPPAPFVNKLQGPKPGSPQCHRSLLQLVKTATKSQSFHASMPASSGTPASSSSSHKTPASCSAAVSHPAKPHSASSSGPPYKTSPFLGSASKHGVSSGSPSSGGTPVQSPASGNLLPTTQPPSTGQSTSRPVPGPAVKKPPVPQKLTLVAPPGGPNGDSSGGTQGVAKLLTSSLKPSAVSSVTSSTSLPKGASGAVLLTGSSSLNLLSSSYKAGSPKLPGALNSSPLGIISQLPLHVISFSADSSAKAGVSKDAIVTGPAPGTFHHGLGHSLLAGVHSSPPRAAPLPHTAVSTHLPQSLPDASQLHGKGPSVPRKL", "length": 1132, "header": "tr|E1BAS8-1|E1BAS8_BOVIN Isoform 1 of Ubinuclein 1 OS=Bos taurus OX=9913 GN=UBN1 PE=3 SV=4 CANONICAL=E1BAS8-1" }, "locus": { "chromosome": "25", "start_pos": 3945882, "end_pos": 3918640, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002274.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002274.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002274.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002274.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 863, "start_aa": "Thr", "end_pos": 863, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr863", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2559584", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559584", "resource": "Reactome", "description": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "E1BAS8", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAS8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1132, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAS8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAS8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" }, { "id": "PF08729", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08729" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Hpc2-related", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 167, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BAS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS8" }, { "id": "PF14075", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14075" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubinuclein middle", "eco_id": "ECO_0000259", "start_pos": 352, "end_pos": 571, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 863 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 228, "end_pos": 230 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAT6-1", "uniprot_ac": "E1BAT6", "uniprot_id": "E1BAT6_BOVIN", "mass": { "chemical_mass": 16369.0, "monoisotopic_mass": 16369.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Small ribosomal subunit protein uS9", "type": "recommended", "evidence": [ { "id": "E1BAT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT6/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S16", "type": "synonym", "evidence": [ { "id": "E1BAT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BAT6", "locus": {} } ], "crossref": [ { "id": "E1BAT6", "url": "https://alphafold.ebi.ac.uk/entry/E1BAT6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001538", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001538", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IIQYDRT", "url": "https://omabrowser.org/oma/group/IIQYDRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21569", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21569", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21569:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21569:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00380", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00380", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAT6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAVDIRVRVKGGGHVAQIYAIHQSISKALVAYYQKYVDEASKKEIKDIIIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR", "length": 145, "header": "tr|E1BAT6-1|E1BAT6_BOVIN Isoform 1 of Small ribosomal subunit protein uS9 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1BAT6-1" }, "isoforms": [ { "isoform_ac": "E1BAT6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAT6/entry", "sequence": { "sequence": "MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAVDIRVRVKGGGHVAQIYAIHQSISKALVAYYQKYVDEASKKEIKDIIIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR", "length": 145, "header": "tr|E1BAT6-1|E1BAT6_BOVIN Isoform 1 of Small ribosomal subunit protein uS9 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1BAT6-1" }, "locus": { "chromosome": "3", "start_pos": 116880304, "end_pos": 116879870, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002015.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002015.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052478.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052478.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P62250-1", "protein_name": "Small ribosomal subunit protein uS9", "gene_name": "Rps16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR", "length": 146 }, "evidence": [ { "id": "E1BAT6", "url": "https://omabrowser.org/oma/group/E1BAT6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "E1BAT6", "url": "https://www.uniprot.org/uniprotkb/E1BAT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAT6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 145, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAT6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAT6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAU3-1", "uniprot_ac": "E1BAU3", "uniprot_id": "E1BAU3_BOVIN", "mass": { "chemical_mass": 287718.0, "monoisotopic_mass": 287718.0 }, "refseq": { "ac": "XP_010799826", "name": "immunoglobulin superfamily member 10 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799826" }, "gene_names": [ { "name": "IGSF10", "type": "recommended", "evidence": [ { "id": "E1BAU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" } ] }, { "name": "IGSF10", "type": "synonym", "evidence": [ { "id": "XP_010799826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799826" } ] } ], "protein_names": [ { "name": "Immunoglobulin superfamily member 10", "type": "recommended", "evidence": [ { "id": "E1BAU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU3/entry#names_and_taxonomy" } ] }, { "name": "Calvaria mechanical force protein 608", "type": "synonym", "evidence": [ { "id": "E1BAU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU3/entry#names_and_taxonomy" } ] }, { "name": "immunoglobulin superfamily member 10 precursor", "type": "synonym", "evidence": [ { "id": "XP_010799826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799826" } ] } ], "function": [ { "annotation": "Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons). May be involved in the maintenance of osteochondroprogenitor cells pool.", "evidence": [ { "database": "UniProtKB", "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3#function" }, { "database": "UniProtKB", "id": "ARBA00054041", "url": "https://www.uniprot.org/uniprotkb/ARBA00054041#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGSF10", "url": "https://www.uniprot.org/uniprotkb/E1BAU3", "locus": { "chromosome": "1", "start_pos": 116652023, "end_pos": 116620552, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001728", "url": "https://www.ensembl.org/id/ENSBTAG00000001728" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001728", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001728", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "537487", "url": "https://www.ncbi.nlm.nih.gov/gene/537487", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VTWIMPD", "url": "https://omabrowser.org/oma/group/VTWIMPD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAU3", "url": "https://www.orthodb.org/?gene=E1BAU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010799826", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799826", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAU3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPKGRGSTNLLLSFTAICLIALPGGGACPRRCACYVPTEVHCTFRYLTSIPESIPPNVERINLGYNSLVRLTEADFSGLNKLELLLLHSNGIHTVPAKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLTSLRLVHLEGNQLTKLHPDTFVSLRYLQIFKTSFIKYLYLSDNFLSSIPQEMVTYMSDLESLYLHGNPWICDCQLKWLADWLREKPDIIKCKKDRSPSSPQQCPLCMNPRTSKGKPLVMVPAAAFLCAKPTIHPSLKLKNLTVLEDSGSVSISPQDFMAPFGSLTLNITDQTGNEANMICSIQKPAMTSSIAFTAENDYITLNASFSTFLVCDIDYSHIQPVWQVLALYSDSPLILERSHLFTETPQLCYKYKQVVLKPEDIFTNIEAGLRADPPWLMQDRISLQLNRTATTLSTLQIQYSSDAQVTLPRSEIKPETYRWTMISKDNNTKLERTVLVGGTVDLDCPGQGEPPPHLEWLLADGSKVRAPYVSEDGRILIGKSGKLGLQMADSSDTGIYHCISTNYDDADILTYRITVVEPNIEAYQENGARHIASVGETLDLPCHSTGIPDASVSWVLPGNTVLQQSSRDKQILNNGTLRLLQVAQKDQGHYRCVAANPVGVDILVNQVLVKIKGQKSAEHNVETDGSGFDEPNSMGQLQDPPATHLPTSPPMGAEAGTHVLSPSKNPKQRVLISQRRGESTSWRYRDHRRQFPPSARRIDPRHWAALLEKAKKNVMPEKQENTTGKPPPPATQLLDIPGEEADSSGVLPPDEQLTVPATKAADVLTRTVAADSRKSPDSPVTSKTDGTPASPIVSPQTLSPEKPRDFRPSTTIKTQVTPRNINPTASSGMQDTTNPNLPNVFPLLTEATLFQDADDMERKKETLQTASPVSVGATAIKDTHIQTLSNAVGKVGIFLGSVNATNSYQRSVTGVGEPRSHHSPPHSTHKPSTTKLPSDPHTAAPSQLHIPRKSTMNGPLSRRFGRWRKVWSRGRIISPHRTPILRQHRFSVARPTFRGSSEESTTAFPAPELSAVCPSCSPRERLTTDEAVLSSPSLSPITLPKTEIASVTAEEPTTLVHNPSLLLENKPNADAEKTTPMIKYFSAESTQVTPTTAVMTHATSISYPSGSKANETTRHSVIVSPLPDPTIKSPVPTTLAITRFSRRKIPWHQIFVNDHMQRETLKNQHKFGSQSSTDSVLPKISPALPTNKVSPFHFETLSASVMKIPSITPATTHLSNTNTHSLVNLPTMKELPSLPIYPTPPSSSSKESSANSVSMQTDMLTTTPTAPASIIINKAQIDRPRARKVQRKKEPQKTMRDPNTSPTQTSGFITSTTVTPPVLTAAETSTKPSVSAFTHSPLENTKEISSTVGLHPGAFNLTAVLEQPSQEGTQALKNITASETTLSSKLQSTPTRNTIRHSTMPTFLSSSATPMPIPTSPPLSNQSEVTDSMATPTFRMMTSTVVEAHESSKHNATPQQLAVTSPQTHPNAKFAVGTIHFTYSNLLPSTPMPALITGKPQDSKLTHSPWSENHFWHKSHPEIAEKGQKPVVVSVLPTPGLPEVTTHASNWDIQKNGKKSGFDKTAVEKITTSEFLPFDTLSRDVFERPRIIGGKAASFTVPANSDAFLPCKAAGNPVPTIHWTRVSSGLDLSKSKLNSRFQVLSNGTLSIQRVDIQDRGQYLCSASNPFGTDHLHVTLSVVSYPPRIMERHTKEITVHSGSTVKLKCRADGRPSPTISWILANQTVISESSEGKRQALVTSDGTLVIHNLSIYDRGFYKCVASNSVGQDALLVKIQVIAAPPVILEQKKQVIAGTWGESLKLPCTAKGNPQPSVHWVLSDGTEVKPLQFVNSKFLFSNGTLFIRNVASSDRGTYECIATSSTGSERRVVIITVEEQETIPRIEFASQKWTEVNLGDKLLLNCSAIGEPKPKIIWRLPSKVVVDQWHRMGSRIHVYPNGSLFVGSVTEKDGGDYLCVARNKMGDDLTLMHVSLRRKPAKIDHKHHFKKQVFHGKDFQVDCKASGSPVPEISWSLPDGTMINSAMQADDSGHRTRRLTLFHNGTLYFNKVGMAEEGNYTCYAQNTLGKDEMQVHLTVITAAPRIQQSYKTNMRVTAGDTAVLDCEVVGEPKPKIFWLLPSNDMISFSKDRYTFHNNGSLSINEVRLLDSGEYVCVARNPSGDDTKAYKLDVVSKPPLINGLYANKTVIKATAVRHSKRHFDCRAEGTPSPQIMWIMPENIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVIQLEVVEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTQFPSGPHNSQYLIASNGSFIIYKTTRDDAGKYRCGARNKVGYIEKLIVLEIGRKPVILTYEPGTVYSFSGDTVLLPCVSFGSPKPHVKWTLPSGYVIDRPQINGNYILHENGTLVIKEATAYDRGNYICKAQNSIGHALITVPVMVVAYPPRITNRLPRSVLTRTGVAVQLHCKALGIPKPEITWEMPDHSLFSAANKGRTRRIRPFYPQGTLVIRNPQTSDSGIYKCTAKNSLGSDYATTYIRVI", "length": 2612, "header": "tr|E1BAU3-1|E1BAU3_BOVIN Isoform 1 of Immunoglobulin superfamily member 10 OS=Bos taurus OX=9913 GN=IGSF10 PE=4 SV=3 CANONICAL=E1BAU3-1" }, "isoforms": [ { "isoform_ac": "E1BAU3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAU3/entry", "sequence": { "sequence": "MKPKGRGSTNLLLSFTAICLIALPGGGACPRRCACYVPTEVHCTFRYLTSIPESIPPNVERINLGYNSLVRLTEADFSGLNKLELLLLHSNGIHTVPAKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLTSLRLVHLEGNQLTKLHPDTFVSLRYLQIFKTSFIKYLYLSDNFLSSIPQEMVTYMSDLESLYLHGNPWICDCQLKWLADWLREKPDIIKCKKDRSPSSPQQCPLCMNPRTSKGKPLVMVPAAAFLCAKPTIHPSLKLKNLTVLEDSGSVSISPQDFMAPFGSLTLNITDQTGNEANMICSIQKPAMTSSIAFTAENDYITLNASFSTFLVCDIDYSHIQPVWQVLALYSDSPLILERSHLFTETPQLCYKYKQVVLKPEDIFTNIEAGLRADPPWLMQDRISLQLNRTATTLSTLQIQYSSDAQVTLPRSEIKPETYRWTMISKDNNTKLERTVLVGGTVDLDCPGQGEPPPHLEWLLADGSKVRAPYVSEDGRILIGKSGKLGLQMADSSDTGIYHCISTNYDDADILTYRITVVEPNIEAYQENGARHIASVGETLDLPCHSTGIPDASVSWVLPGNTVLQQSSRDKQILNNGTLRLLQVAQKDQGHYRCVAANPVGVDILVNQVLVKIKGQKSAEHNVETDGSGFDEPNSMGQLQDPPATHLPTSPPMGAEAGTHVLSPSKNPKQRVLISQRRGESTSWRYRDHRRQFPPSARRIDPRHWAALLEKAKKNVMPEKQENTTGKPPPPATQLLDIPGEEADSSGVLPPDEQLTVPATKAADVLTRTVAADSRKSPDSPVTSKTDGTPASPIVSPQTLSPEKPRDFRPSTTIKTQVTPRNINPTASSGMQDTTNPNLPNVFPLLTEATLFQDADDMERKKETLQTASPVSVGATAIKDTHIQTLSNAVGKVGIFLGSVNATNSYQRSVTGVGEPRSHHSPPHSTHKPSTTKLPSDPHTAAPSQLHIPRKSTMNGPLSRRFGRWRKVWSRGRIISPHRTPILRQHRFSVARPTFRGSSEESTTAFPAPELSAVCPSCSPRERLTTDEAVLSSPSLSPITLPKTEIASVTAEEPTTLVHNPSLLLENKPNADAEKTTPMIKYFSAESTQVTPTTAVMTHATSISYPSGSKANETTRHSVIVSPLPDPTIKSPVPTTLAITRFSRRKIPWHQIFVNDHMQRETLKNQHKFGSQSSTDSVLPKISPALPTNKVSPFHFETLSASVMKIPSITPATTHLSNTNTHSLVNLPTMKELPSLPIYPTPPSSSSKESSANSVSMQTDMLTTTPTAPASIIINKAQIDRPRARKVQRKKEPQKTMRDPNTSPTQTSGFITSTTVTPPVLTAAETSTKPSVSAFTHSPLENTKEISSTVGLHPGAFNLTAVLEQPSQEGTQALKNITASETTLSSKLQSTPTRNTIRHSTMPTFLSSSATPMPIPTSPPLSNQSEVTDSMATPTFRMMTSTVVEAHESSKHNATPQQLAVTSPQTHPNAKFAVGTIHFTYSNLLPSTPMPALITGKPQDSKLTHSPWSENHFWHKSHPEIAEKGQKPVVVSVLPTPGLPEVTTHASNWDIQKNGKKSGFDKTAVEKITTSEFLPFDTLSRDVFERPRIIGGKAASFTVPANSDAFLPCKAAGNPVPTIHWTRVSSGLDLSKSKLNSRFQVLSNGTLSIQRVDIQDRGQYLCSASNPFGTDHLHVTLSVVSYPPRIMERHTKEITVHSGSTVKLKCRADGRPSPTISWILANQTVISESSEGKRQALVTSDGTLVIHNLSIYDRGFYKCVASNSVGQDALLVKIQVIAAPPVILEQKKQVIAGTWGESLKLPCTAKGNPQPSVHWVLSDGTEVKPLQFVNSKFLFSNGTLFIRNVASSDRGTYECIATSSTGSERRVVIITVEEQETIPRIEFASQKWTEVNLGDKLLLNCSAIGEPKPKIIWRLPSKVVVDQWHRMGSRIHVYPNGSLFVGSVTEKDGGDYLCVARNKMGDDLTLMHVSLRRKPAKIDHKHHFKKQVFHGKDFQVDCKASGSPVPEISWSLPDGTMINSAMQADDSGHRTRRLTLFHNGTLYFNKVGMAEEGNYTCYAQNTLGKDEMQVHLTVITAAPRIQQSYKTNMRVTAGDTAVLDCEVVGEPKPKIFWLLPSNDMISFSKDRYTFHNNGSLSINEVRLLDSGEYVCVARNPSGDDTKAYKLDVVSKPPLINGLYANKTVIKATAVRHSKRHFDCRAEGTPSPQIMWIMPENIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVIQLEVVEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTQFPSGPHNSQYLIASNGSFIIYKTTRDDAGKYRCGARNKVGYIEKLIVLEIGRKPVILTYEPGTVYSFSGDTVLLPCVSFGSPKPHVKWTLPSGYVIDRPQINGNYILHENGTLVIKEATAYDRGNYICKAQNSIGHALITVPVMVVAYPPRITNRLPRSVLTRTGVAVQLHCKALGIPKPEITWEMPDHSLFSAANKGRTRRIRPFYPQGTLVIRNPQTSDSGIYKCTAKNSLGSDYATTYIRVI", "length": 2612, "header": "tr|E1BAU3-1|E1BAU3_BOVIN Isoform 1 of Immunoglobulin superfamily member 10 OS=Bos taurus OX=9913 GN=IGSF10 PE=4 SV=3 CANONICAL=E1BAU3-1" }, "locus": { "chromosome": "1", "start_pos": 116651029, "end_pos": 116623017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002263.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002263.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002263.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002263.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1292, "start_aa": "Thr", "end_pos": 1292, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1292", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1587, "start_aa": "Thr", "end_pos": 1587, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1587", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q3V1M1-1", "protein_name": "Immunoglobulin superfamily member 10", "gene_name": "Igsf10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQKRGREVSCLLISLTAICLVVTPGSRVCPRRCACYVPTEVHCTFRYLTSIPDGIPANVERVNLGYNSLTRLTENDFSGLSRLELLMLHSNGIHRVSDKTFSGLQSLQVLKMSYNKVQIIEKDTLYGLRSLTRLHLDHNNIEFINPEAFYGLTLLRLVHLEGNRLTKLHPDTFVSLSYLQIFKTSFIKYLYLSDNFLTSLPKEMVSSMPNLESLYLHGNPWTCDCHLKWLSEWMQGNPDIIKCKKERIPSSPQQCPLCMNPRISKGRSIAMVPSGSFLCTKPTIDPSLKSKSLGIQEDNGSASVSPQDFIEPFGSLSLNMTDLSGNKANVICSIQKPSRTLPIAFTEENDYIMLNMSFSTNLVCSVNYNHIQPVWQLLALYSDSPLILERKPQHTETPLLSPKYQQVALRPEDTFTNIEADFKADPFWFQQEKISLQLNRTATTLSTLQIQFSTDAQITLPKAEMRPVKRKWTMILMMNNTRLEHTVLVGGTIALDCPGKGDPSPHLEWVLADGSKVRAPYVSEDGRILIDKKGKLELQMADTFDAGLYHCISTNDADADILTYRITVVEPYVENKHENGALHTVIMGEILDLPCLSTGIPDASISWILPRNTVFSQSSRDMQILNNGTLRILQATPKDQGHYRCVAANPSGADFSSFQVSVQMKGQRTIEHDRDIDGSGLEEPKPSVLLKQPPSLKLPASSLTGTEAGKQVSGIHKKNKHRDLTHRRRGDSTLRRFREHRRQLPLSARRIDPQHWAALLEKAKKNSVLRKQENTTVKPTPLAIPLVELAGEEKDASGLTPPDEEFTVLKTKAFGVPERSPTADSRPVNHGFVTSSASGTEVSSTVNPQTLLPTHLPDFKLFNVVDSAAVSKSMNRPVTSKIEDTTHQNPIIIFPSVAEIQDSAQVGRTSSQSAHPATGGAMATYGYTTMLSSFTNKANTVLQSANPTESYGPQIPLTEVSRVSSNNSLAHTTKDPGFSKRPSDSHTTAPSLFQTPRNNSTGNVGRERTIWSRGRAISPYRTPVLRRHRHRIVRPALKGPANRNISQVSATEPPGMCRTCSSTERLTMATAALSVTGSSHTTLPKANNVGIISEESTTVVKKPSLLLKNKQDVDIETITTTINYFRSESTHMTPTEASMISAPTSISLGKTPIDTSGHLSMPRTIQAGTDLVVTPPLSSPLSQPSIPTKATSTKLSRRKIPWHPIFANNHNKEGMLKNLHQFGLQKNTATKPPEKAPLLPTDHGSSSPSTTLLASLTPAQSATMAATRRNGTEVQGARSLSAGKEQPFINSFLVLPSTTRKRSSTLSFLSVETPTVTTPPVIASAIISETQEVRSKKAKDQTKGSLKNRKGPTITPRQISGYSTYSVPTTTDTPLAFSHSPGKVTGRTVSTAAPHSAASLLGITELPQKCTHTSGNITASETTLLSKSQESTAMKRASATPPLLSSGAPRMPTPSPPPFTKVVVTDSEVPAVFKMMSNRMVTIYESSRHDIDLQQPSAEASPNPEILTGSTDFPLSSLLTSTPMPAPRVDKPQDSQWKPSPWPENKFQLRSYSETIEKGKRPEISLSPHLSFPEASTHALHWNAQRHAEKSVFDKKPAQNPTSKHLPYDSLPKTILKKPRIIGGKAASFTVPTNSDVLLPCEAVGDPKPTIHWTRVSSGREISRGIQKTRFHVLPNGTLSIQRVSIQDRGQYLCAASNPLGVDHLHVTLSVVSYPARILESHVKEITAHSGSTVKLKCRVEGMPRPTISWILANQTVVSETPEGSRKVWVTPDGTLIIHNLSLYDRGFYKCVANNPSGQDSLLVKIQVITAPPVIIEQKRQAIVGVLGESLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRFFLYPNGTLYIRNIVSSVRGTYECIATSSSGSERRVVILRVEEQETVPRIETASQKWTEVNLGEKLLLNCSATGDPKPTIIWKLPSKVVIDQWHRMGSRIHVYPNGSLVIGSVTEKDGGDYLCVARNKMGDDLVLMHVRLRLTPAKIEHKQHFKKQVLHGKDFQVDCKASGSPVPEVSWSLPDGTVVNNVAQADDSGYRTKRYTLFHNGTLYFNKVGMAEEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQNYRSNVRIKAGDTAVLDCEVTGEPKPNVFWLLPSNNVISFSNDRFIFHANGTLSINKVKPLDSGKYVCVAQNPSGDDTKTYKLDIVSRPPLINGLYANKTVIKATAIQHSKKHLDCRADGVPPPQITWIMPDNIFLTAPYYGGRITVHQNGTLEIRNIRLSDSADFTCVVRSEGGESVLVVQLKVLEMLRRPTFRNPFNEKVVAQVGKPVAMNCSVDGNPTPEIIWILPDGTQFANGPQNSPYLMASNGSLIVYKATRNKSGKYRCTARNKVGYIEKLILLEIGQKPVILTYEPGMIKSAGGESLSLHCVSDGIPKPNVKWTTPGGLVIDRPQVGGKYILHENGTLVIKETTAHDRGNYICKAQNSVGQAVISVPVTIVAYPPRIINYLPRSMLRRTGEAMQLHCVALGVPKPQITWETPGYSLLSTATERRPHRSEMLPLQGTLVIQNLRASDSGVYKCRAQNVLGADYATTYIQVL", "length": 2594 }, "evidence": [ { "id": "E1BAU3", "url": "https://omabrowser.org/oma/group/E1BAU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6WRH9-1", "protein_name": "Immunoglobulin superfamily member 10", "gene_name": "Igsf10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQVRGREVSGLLISLTAVCLVVTPGSRACPRRCACYVPTEVHCTFRYLTSIPDGIPANVERINLGYNSLTRLTENDFDGLSKLELLMLHSNGIHRVSDKTFSGLQSLQVLKMSYNKVQIIRKDTFYGLGSLVRLHLDHNNIEFINPEAFYGLTSLRLVHLEGNRLTKLHPDTFVSLSYLQIFKTSFIKYLFLSDNFLTSLPKEMVSYMPNLESLYLHGNPWTCDCHLKWLSEWMQGNPDIIKCKKDRSSSSPQQCPLCMNPRISKGRPFAMVPSGAFLCTKPTIDPSLKSKSLVTQEDNGSASTSPQDFIEPFGSLSLNMTDLSGNKADMVCSIQKPSRTSPTAFTEENDYIMLNASFSTNLVCSVDYNHIQPVWQLLALYSDSPLILERKPQLTETPSLSSRYKQVALRPEDIFTSIEADVRADPFWFQQEKIVLQLNRTATTLSTLQIQFSTDAQIALPRAEMRAERLKWTMILMMNNPKLERTVLVGGTIALSCPGKGDPSPHLEWLLADGSKVRAPYVSEDGRILIDKNGKLELQMADSFDAGLYHCISTNDADADVLTYRITVVEPYGESTHDSGVQHTVVTGETLDLPCLSTGVPDASISWILPGNTVFSQPSRDRQILNNGTLRILQVTPKDQGHYQCVAANPSGADFSSFKVSVQKKGQRMVEHDREAGGSGLGEPNSSVSLKQPASLKLSASALTGSEAGKQVSGVHRKNKHRDLIHRRRGDSTLRRFREHRRQLPLSARRIDPQRWAALLEKAKKNSVPKKQENTTVKPVPLAVPLVELTDEEKDASGMIPPDEEFMVLKTKASGVPGRSPTADSGPVNHGFMTSIASGTEVSTVNPQTLQSEHLPDFKLFSVTNGTAVTKSMNPSIASKIEDTTNQNPIIIFPSVAEIRDSAQAGRASSQSAHPVTGGNMATYGHTNTYSSFTSKASTVLQPINPTESYGPQIPITGVSRPSSSDISSHTTADPSFSSHPSGSHTTASSLFHIPRNNNTGNFPLSRHLGRERTIWSRGRVKNPHRTPVLRRHRHRTVRPAIKGPANKNVSQVPATEYPGMCHTCPSAEGLTVATAALSVPSSSHSALPKTNNVGVIAEESTTVVKKPLLLFKDKQNVDIEIITTTTKYSGGESNHVIPTEASMTSAPTSVSLGKSPVDNSGHLSMPGTIQTGKDSVETTPLPSPLSTPSIPTSTKFSKRKTPLHQIFVNNQKKEGMLKNPYQFGLQKNPAAKLPKIAPLLPTGQSSPSDSTTLLTSPPPALSTTMAATQNKGTEVVSGARSLSAGKKQPFTNSSPVLPSTISKRSNTLNFLSTETPTVTSPTATASVIMSETQRTRSKEAKDQIKGPRKNRNNANTTPRQVSGYSAYSALTTADTPLAFSHSPRQDDGGNVSAVAYHSTTSLLAITELFEKYTQTLGNTTALETTLLSKSQESTTVKRASDTPPPLLSSGAPPVPTPSPPPFTKGVVTDSKVTSAFQMTSNRVVTIYESSRHNTDLQQPSAEASPNPEIITGTTDSPSNLFPSTSVPALRVDKPQNSKWKPSPWPEHKYQLKSYSETIEKGKRPAVSMSPHLSLPEASTHASHWNTQKHAEKSVFDKKPGQNPTSKHLPYVSLPKTLLKKPRIIGGKAASFTVPANSDVFLPCEAVGDPLPIIHWTRVSSGLEISQGTQKSRFHVLPNGTLSIQRVSIQDRGQYLCSAFNPLGVDHFHVSLSVVFYPARILDRHVKEITVHFGSTVELKCRVEGMPRPTVSWILANQTVVSETAKGSRKVWVTPDGTLIIYNLSLYDRGFYKCVASNPSGQDSLLVKIQVITAPPVIIEQKRQAIVGVLGGSLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRFFLYPNGTLYIRSIAPSVRGTYECIATSSSGSERRVVILTVEEGETIPRIETASQKWTEVNLGEKLLLNCSATGDPKPRIIWRLPSKAVIDQWHRMGSRIHVYPNGSLVVGSVTEKDAGDYLCVARNKMGDDLVLMHVRLRLTPAKIEQKQYFKKQVLHGKDFQVDCKASGSPVPEVSWSLPDGTVLNNVAQADDSGYRTKRYTLFHNGTLYFNNVGMAEEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQSYKTTMRLRAGETAVLDCEVTGEPKPNVFWLLPSNNVISFSNDRFTFHANRTLSIHKVKPLDSGDYVCVAQNPSGDDTKTYKLDIVSKPPLINGLYANKTVIKATAIRHSKKYFDCRADGIPSSQVTWIMPGNIFLPAPYFGSRVTVHPNGTLEMRNIRLSDSADFTCVVRSEGGESVLVVQLEVLEMLRRPTFRNPFNEKVIAQAGKPVALNCSVDGNPPPEITWILPDGTQFANRPHNSPYLMAGNGSLILYKATRNKSGKYRCAARNKVGYIEKLILLEIGQKPVILTYEPGMVKSVSGEPLSLHCVSDGIPKPNVKWTTPGGHVIDRPQVDGKYILHENGTLVIKATTAHDQGNYICRAQNSVGQAVISVSVMVVAYPPRIINYLPRNMLRRTGEAMQLHCVALGIPKPKVTWETPRHSLLSKATARKPHRSEMLHPQGTLVIQNLQTSDSGVYKCRAQNLLGTDYATTYIQVL", "length": 2597 }, "evidence": [ { "id": "E1BAU3", "url": "https://omabrowser.org/oma/group/E1BAU3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6WRI0-1", "protein_name": "Immunoglobulin superfamily member 10", "gene_name": "IGSF10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVMQIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI", "length": 2623 }, "evidence": [ { "id": "E1BAU3", "url": "https://omabrowser.org/oma/group/E1BAU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" } ], "pmid": "" }, { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" } ], "pmid": "" }, { "name": "regulation of neuron migration", "id": "GO:2001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001222", "evidence": [ { "database": "UniProtKB", "id": "E1BAU3", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1163, "end_pos": 1165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1352, "end_pos": 1354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1409, "end_pos": 1411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1427, "end_pos": 1429, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1474, "end_pos": 1476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1504, "end_pos": 1506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1695, "end_pos": 1697, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1773, "end_pos": 1775, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1799, "end_pos": 1801, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1888, "end_pos": 1890, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1951, "end_pos": 1953, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1987, "end_pos": 1989, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2090, "end_pos": 2092, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2105, "end_pos": 2107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2184, "end_pos": 2186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2232, "end_pos": 2234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2284, "end_pos": 2286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2347, "end_pos": 2349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2364, "end_pos": 2366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2382, "end_pos": 2384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2477, "end_pos": 2479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 627, "end_pos": 629, "annotation": "n_glycosylation_sequon" }, { "start_pos": 774, "end_pos": 776, "annotation": "n_glycosylation_sequon" }, { "start_pos": 952, "end_pos": 954, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU3" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 461, "end_pos": 567, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1292, 1587 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1163, "end_pos": 1165 }, { "start_pos": 1352, "end_pos": 1354 }, { "start_pos": 1409, "end_pos": 1411 }, { "start_pos": 1427, "end_pos": 1429 }, { "start_pos": 1474, "end_pos": 1476 }, { "start_pos": 1504, "end_pos": 1506 }, { "start_pos": 1695, "end_pos": 1697 }, { "start_pos": 1773, "end_pos": 1775 }, { "start_pos": 1799, "end_pos": 1801 }, { "start_pos": 1888, "end_pos": 1890 }, { "start_pos": 1951, "end_pos": 1953 }, { "start_pos": 1987, "end_pos": 1989 }, { "start_pos": 2090, "end_pos": 2092 }, { "start_pos": 2105, "end_pos": 2107 }, { "start_pos": 2184, "end_pos": 2186 }, { "start_pos": 2232, "end_pos": 2234 }, { "start_pos": 2284, "end_pos": 2286 }, { "start_pos": 2347, "end_pos": 2349 }, { "start_pos": 2364, "end_pos": 2366 }, { "start_pos": 2382, "end_pos": 2384 }, { "start_pos": 2477, "end_pos": 2479 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 627, "end_pos": 629 }, { "start_pos": 774, "end_pos": 776 }, { "start_pos": 952, "end_pos": 954 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAV1-1", "uniprot_ac": "E1BAV1", "uniprot_id": "E1BAV1_BOVIN", "mass": { "chemical_mass": 94448.0, "monoisotopic_mass": 94448.0 }, "refseq": { "ac": "NP_001179616", "name": "leucine-rich repeat and guanylate kinase domain-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179616" }, "gene_names": [ { "name": "LRGUK", "type": "recommended", "evidence": [ { "id": "E1BAV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ] }, { "name": "LRGUK", "type": "synonym", "evidence": [ { "id": "NP_001179616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179616" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BAV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV1/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat and guanylate kinase domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001179616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179616" } ] } ], "function": [ { "annotation": "Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1#function" }, { "database": "UniProtKB", "id": "ARBA00054148", "url": "https://www.uniprot.org/uniprotkb/ARBA00054148#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRGUK", "url": "https://www.uniprot.org/uniprotkb/E1BAV1", "locus": { "chromosome": "4", "start_pos": 97891417, "end_pos": 97789937, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015773", "url": "https://www.ensembl.org/id/ENSBTAG00000015773" } ] } } ], "crossref": [ { "id": "E1BAV1", "url": "https://alphafold.ebi.ac.uk/entry/E1BAV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015773", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015773", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529920", "url": "https://www.ncbi.nlm.nih.gov/gene/529920", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529920", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529920", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CNQISEM", "url": "https://omabrowser.org/oma/group/CNQISEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAV1", "url": "https://www.orthodb.org/?gene=E1BAV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23117:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23117:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179616", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAV1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSGREPKFPKPSSLQGGKSISRTGAQSKVLHSEKDRHSCWSPFPMGQRPKNTLCKASSYLLQHLIHRYQESDVDRDYYDLEEGEGEGEVESEESSESEMLNFEGGFDGVLREEVVAEKLYQLGRSGSGTEQVYLSLTLSDLDLTDVSILCGYVHLQKLDLSVNKIEDLSCVSCMPYLLELNASQNHLKTFFNFKPPKKLKKVDFSYNQISEMCSLSAYESLTKLILDSNEITEISGLELCSSLTYLSLANNKITTINGLGMLPIKILCLSNNQIEKMTGLDDLRVLQILDLSQNQISSLQGLEGHDFLEVINLEDNKVAELGEIEYIENLPLLRVLNLLRNPVREKPDYWSFVIFMLLRLTELDQKKIKVDEKISAVNKYNPPPEVVAAQDHMTHVVNSVMQPQRIFDSTLPSLDAPYPMLVLAGPQACGKRELAHRLCRQFSTYFRYGACHTTRLPYFGEGDRVDYHFTSQEVFDEMQNMGKFILTYNYGNHKYGLSRDTIEGIARDGLASCVHMEIEGVRSLKHCYFEPRYILVVPMDKQKYEGYLRRKGLFSRVEIEFAVSRVDLYIKINQKYPGYFDAVINADDLDVAYQKLSQLIREYLGFSEVTAKSLAPTTDTKKPQLKPEKISRKLRVSNEFESLDFADRNYFVKLWARLSGKKTPVERESLARQYETARQTLMGNTPPQHTFLFQRGLVPAPIINSLRYFTALELKKSFELYGDYFKAPFGPSEKSVMDSSDSMQYPELLHSCPWPKDLPFQPLEDRIYSQPGSIIGDTEDHALKALYKQAFPHGKGSLQHRRHMVSAISRPGSNIKPTLPPIPQGRK", "length": 829, "header": "tr|E1BAV1-1|E1BAV1_BOVIN Isoform 1 of Leucine-rich repeat and guanylate kinase domain-containing protein OS=Bos taurus OX=9913 GN=LRGUK PE=4 SV=2 CANONICAL=E1BAV1-1" }, "isoforms": [ { "isoform_ac": "E1BAV1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1/entry", "sequence": { "sequence": "MATSGREPKFPKPSSLQGGKSISRTGAQSKVLHSEKDRHSCWSPFPMGQRPKNTLCKASSYLLQHLIHRYQESDVDRDYYDLEEGEGEGEVESEESSESEMLNFEGGFDGVLREEVVAEKLYQLGRSGSGTEQVYLSLTLSDLDLTDVSILCGYVHLQKLDLSVNKIEDLSCVSCMPYLLELNASQNHLKTFFNFKPPKKLKKVDFSYNQISEMCSLSAYESLTKLILDSNEITEISGLELCSSLTYLSLANNKITTINGLGMLPIKILCLSNNQIEKMTGLDDLRVLQILDLSQNQISSLQGLEGHDFLEVINLEDNKVAELGEIEYIENLPLLRVLNLLRNPVREKPDYWSFVIFMLLRLTELDQKKIKVDEKISAVNKYNPPPEVVAAQDHMTHVVNSVMQPQRIFDSTLPSLDAPYPMLVLAGPQACGKRELAHRLCRQFSTYFRYGACHTTRLPYFGEGDRVDYHFTSQEVFDEMQNMGKFILTYNYGNHKYGLSRDTIEGIARDGLASCVHMEIEGVRSLKHCYFEPRYILVVPMDKQKYEGYLRRKGLFSRVEIEFAVSRVDLYIKINQKYPGYFDAVINADDLDVAYQKLSQLIREYLGFSEVTAKSLAPTTDTKKPQLKPEKISRKLRVSNEFESLDFADRNYFVKLWARLSGKKTPVERESLARQYETARQTLMGNTPPQHTFLFQRGLVPAPIINSLRYFTALELKKSFELYGDYFKAPFGPSEKSVMDSSDSMQYPELLHSCPWPKDLPFQPLEDRIYSQPGSIIGDTEDHALKALYKQAFPHGKGSLQHRRHMVSAISRPGSNIKPTLPPIPQGRK", "length": 829, "header": "tr|E1BAV1-1|E1BAV1_BOVIN Isoform 1 of Leucine-rich repeat and guanylate kinase domain-containing protein OS=Bos taurus OX=9913 GN=LRGUK PE=4 SV=2 CANONICAL=E1BAV1-1" }, "locus": { "chromosome": "4", "start_pos": 97890972, "end_pos": 97789937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020944.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020944.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020944.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020944.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 678, "start_aa": "Thr", "end_pos": 678, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr678", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529920", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529920", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GHE9-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "Lrguk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATFEGSPSRWKGTRFQRSLGASRAVAQAILSLTDKEPQKRWPTFPMGLRSKGTFRSASSYLLHQLIHRSHEAEVEQEEQQEEGESEESEESEMQNLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNRLTTFFNFKPPQNLKKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNRKFPGYFDAVINADDLDIAYQKLSELIREYLGLTETAKKGLAPTAGASSSKKTVSGVPAHLVPSPRRLARLQADGQKTEAFLEVQPHAMIPENQNPTLPQSQDLTEEGEAPKKEASPSHLDLPQQTQDISPKVKEEDGQPANLPPKITTETEGPEDEPVPPVLEAGQSSTMASQEPPQHPAPAPPLSPQLDQDKESGETKVTPNNPALSEPAQGPDPASVSPQRVQDEGAESANLASSSSTHNLPEDPSHAEIEKPTVGSQPSLKEETPKAEVMRASTPYPEIPPPQDSSTKVREQPVALLPRSRLAPTRLPQPQTLAPLQSRRPTPKLLSPSREEALGTSSEQTPNPSPRSLPTQDGDPSKLPPISPPQSKPPQNPSPHAVHSPQQAQVEKGSEVKLPLISPPVQEQALQHTPKPPQEEEAPTVRLPNIPAPSTEPHLPQNTEPRPASKPARERKTPKVGRASSKKVLDLQATPHSQELTKQKGARKKTLTQRETAKELPHPKKMPIGNSQTAQQPESHSRPTPRNESDALDFRSSPGHTEPVSADPQNREKNRKAHNPRKKAQTNPTPKDASQSTRTSPNGEMSEGLTQGNETALSEDQPTREGQPPQATDQSAQDIAVPSQLRAKESQAQRNTRETRQSYAQRHSILVSKQQSKEKRTRKNGGVPQDRSPAAPQNEVSQEDPGSQTGRLRARGSQSIKV", "length": 1270 }, "evidence": [ { "id": "E1BAV1", "url": "https://omabrowser.org/oma/group/E1BAV1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7J6M1-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "Lrguk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAASEKGSSRGKASSLQGGLSCAVIQTIRALAAKHRRTPWPPFPMGQKSKGTYRSASSFLLEQLMQRSQEAEDRHGEEESEESVESEIMNLEEDFDGILREEAVAEALSDLGWSGPGTEQVYLNLNLSNCELVDVSVLCDYIHLQKLNLSANKIEDLSCVSHMPYLLELNASQNKLTTFFNFKPPKNLQKVDFSHNEISEMGDLSAYHTLTQLILDNNEIEDISGIENCVCLTHLSLAANKITAINGLGTLPIKVLCLRHNNIETITGLEDLKALQKLDLSYNRISSLQGLENHDLLEMINLEDNKIEELSEIEYIENLPMLRVLNLLKNPIQEKSEYWLFVIFMLLRLTELDQQKIRVEEKVTAVNKYDPPPEVVAVRDHMTHIVNSMSQPQRIFDSTLPSLDAPYPMLVLTGPAACGKRELAHRLCRQFNTYFRYGACHTTRPPYFGEGDRVDYHFISQEVFDEMLSMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHLEIEGVRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIDFTVSRVDIYIKMNRKFPGYFDAVINADDLDIAYKKLSEIIREYLGLTEEVDKGLAPTAAGGPSSKKTISGVPAHLVPSPRRLARLQADGQNPEALLEVQTHSKSPLPQSQESTEEGQPPKKDPSPSSHLNPPQEVSSSTLGNPQPAQDISPKGKVGGGQAAHLPPKIITEMDEPEDEPGPHELKAEGQSSTIASQEPPQHPNPPPQPSPQPDQDKKSGESKGAPRTLPEPAGPDPASLSPQRVQDEGTEPANPAPSSSPHNPPEDPAPSDVVKPTGGSQPPLKDGTPKAEVVRASTPYPEIPPPQDKSTNSKHTQVMEQPMALLPRSRLAPTRLPQPQNLAPLQSRRPTPKLLSPSREEALGTSSDQTPAPSPRSLPTQDDPGKLPLISPPQSKPPPNPSPNAAHSPQQAHAGKASEVKLPLISPPVQEQAQQHSPNPPQEEAAAPTVHFPHIAAPSVEPSLPQNTRPRPASKPAKGRETPKVGHGHASNKKIPGLQASPHSQETAKQKDTRKKNLRQRETAKGSPHLRKIPAGKSQTAQQWESHNKPTPRNVSHPLDSGSPLSHTKATSADPQNQEEKTRKAQNSGKKDLAQSIGTSPNPEMSEGLVQEKVLSENQSIQEAQLPQPAAKSGHGEQAQKKERSQKREVSGKSPEQGTAAPSQLRAKETQALKDSSELRQGYAQRHSIRTSKQQSKEKRTRKNGDAPQSRSPAAPQDQMSEEEPSSRTGRLRARGSQSIKV", "length": 1289 }, "evidence": [ { "id": "E1BAV1", "url": "https://omabrowser.org/oma/group/E1BAV1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0AB32TU23-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "lrguk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVRSGSVSDRTPAHLPVSLCAISGFYRMTFYWHLNRISDCVWPQGRDLKNVSILCNYIYLQKLELPYNKIKDLSCVSHMPYLITLDASHNQLTDFFGFQPPKNLKEVNFSHNQMTAMKDLSAYSSLTKLILDHNSFSVIRGLEKCKRLSHLSLAHNNISRIRGLDHLPLRELCLAGNMINKIENLQTLHNLQVLDLSCNRIQSLTGLQNLRFLGTVNLESNLITEIKEAAHLHDLILLREINLLKNPVQDHDDYRIAVIFLLQHLILLDKQTVTAEEKVAAVNKYDPPLEVVAARDHMTHLVYQLMQPQVIFDSTLPSLDAPYPMLVLTGPQACGKRELAHKLCQEFSDYFAYGACHTTRGPYFGEEDGLDYHFVTEEEFHNMIQMGQFIQTMQYGGHWYGLSRESIERVAREGLACCVHMELEGVFSLKNSYFEPRYVLLIPSVVDNYVLFLKARGFYSNAQMETAVSRIDLYARINRERPGFFDSIIPCDDRAEAYRSLKQLVKEYLGLEEHSGGGDSSSITPDNTSTNTTGELPAASATESTDLMDSYSRNYQKKIQANMTPQRTEMASNHRRLQQIREALSGKSPGAYAELFQRSVPAAPSSLASQSHPPAGPSSSPVRPAGLSAPNLSEDSSSEESRASSGLSMRSSAGVFSAESPARGSDAGSGPNIEPLDISMLGQDRDSLRGLTPDAPRPASDRVSPTHPSSPGRPGANVKPVLPPIPSGRKTNDSGSKQ", "length": 739 }, "evidence": [ { "id": "E1BAV1", "url": "https://omabrowser.org/oma/group/E1BAV1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96M69-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "LRGUK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSYLLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGRSGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLGLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTPAERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR", "length": 825 }, "evidence": [ { "id": "E1BAV1", "url": "https://omabrowser.org/oma/group/E1BAV1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GMP kinase activity", "id": "GO:0004385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004385", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BAV1", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAV1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 829, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAV1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAV1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV1" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 420, "end_pos": 603, "start_aa": "Tyr", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 678 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAZ5-1", "uniprot_ac": "E1BAZ5", "uniprot_id": "E1BAZ5_BOVIN", "mass": { "chemical_mass": 50798.0, "monoisotopic_mass": 50798.0 }, "refseq": { "ac": "XP_002691232", "name": "major facilitator superfamily domain-containing protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691232" }, "gene_names": [ { "name": "MFSD9", "type": "recommended", "evidence": [ { "id": "E1BAZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5" } ] }, { "name": "MFSD9", "type": "synonym", "evidence": [ { "id": "XP_002691232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691232" } ] } ], "protein_names": [ { "name": "Major facilitator superfamily domain containing 9", "type": "synonym", "evidence": [ { "id": "E1BAZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5/entry#names_and_taxonomy" } ] }, { "name": "major facilitator superfamily domain-containing protein 9", "type": "synonym", "evidence": [ { "id": "XP_002691232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691232" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAZ5", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFSD9", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5", "locus": { "chromosome": "11", "start_pos": 7431258, "end_pos": 7443026, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001714", "url": "https://www.ensembl.org/id/ENSBTAG00000001714" } ] } } ], "crossref": [ { "id": "E1BAZ5", "url": "https://alphafold.ebi.ac.uk/entry/E1BAZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001714", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001714", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17390", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17390", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514165", "url": "https://www.ncbi.nlm.nih.gov/gene/514165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514165", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RFVRCLY", "url": "https://omabrowser.org/oma/group/RFVRCLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAZ5", "url": "https://www.orthodb.org/?gene=E1BAZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23504", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23504", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23504:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23504:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691232", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691232", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BAZ5", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRMEPGDQTSGMAPDRGLVSATRRPRQEPGTGTQEGAPGPGAVRARRFLLCLYLVGFLDLFGVSMVVPLLSVHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLVCILCSALGYLLLGASTNVFLFTLARVPAGIFKHTLSISRALLADLVTEEERPVVLGQFNTASSMGFILGPVVGGYLAELDGGFYLTAFVCSSVFVLNAGLVWLFPWSEVKLSGPEDDLPRGRNQALWEKTDSAVQRAASAHGTPASPQGTPVSKGPARLLWAEVLATLWGLRSLVLSALWVVFLVRLLMAVAVMLYYSNFVLALEERFSMGPRAAGYVTSCGSALGVLAGFALGPLLRLYGHQSYRLLLHSSVLTSMLLLLFASARSLDVAVACSVLLSFSTAIGRTCITDLQLTVGGVRAGGSLLGMGQSVTAVGRVLAPILSGVAQEVSPCGPPGLGAALGFVAVVIMSRNRPHSGGQGGDQLKSE", "length": 485, "header": "tr|E1BAZ5-1|E1BAZ5_BOVIN Isoform 1 of Major facilitator superfamily domain containing 9 OS=Bos taurus OX=9913 GN=MFSD9 PE=4 SV=2 CANONICAL=E1BAZ5-1" }, "isoforms": [ { "isoform_ac": "E1BAZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5/entry", "sequence": { "sequence": "MRMEPGDQTSGMAPDRGLVSATRRPRQEPGTGTQEGAPGPGAVRARRFLLCLYLVGFLDLFGVSMVVPLLSVHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLVCILCSALGYLLLGASTNVFLFTLARVPAGIFKHTLSISRALLADLVTEEERPVVLGQFNTASSMGFILGPVVGGYLAELDGGFYLTAFVCSSVFVLNAGLVWLFPWSEVKLSGPEDDLPRGRNQALWEKTDSAVQRAASAHGTPASPQGTPVSKGPARLLWAEVLATLWGLRSLVLSALWVVFLVRLLMAVAVMLYYSNFVLALEERFSMGPRAAGYVTSCGSALGVLAGFALGPLLRLYGHQSYRLLLHSSVLTSMLLLLFASARSLDVAVACSVLLSFSTAIGRTCITDLQLTVGGVRAGGSLLGMGQSVTAVGRVLAPILSGVAQEVSPCGPPGLGAALGFVAVVIMSRNRPHSGGQGGDQLKSE", "length": 485, "header": "tr|E1BAZ5-1|E1BAZ5_BOVIN Isoform 1 of Major facilitator superfamily domain containing 9 OS=Bos taurus OX=9913 GN=MFSD9 PE=4 SV=2 CANONICAL=E1BAZ5-1" }, "locus": { "chromosome": "11", "start_pos": 7442827, "end_pos": 7432262, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002247.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002247.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002247.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002247.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514165", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNG6-1", "protein_name": "Major facilitator superfamily domain containing 9", "gene_name": "MFSD9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERGDSRGMAPDRGLVSARQRPWQDPGTGTQVGDPGLGPVRARRFLLCLYVVGFLDLLGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRPSLLVCLLCSALGYLILGTSTNVFLFALARVPVGIFKHTLSISRALLSDLVTEKERPLVLGQFNTASSVGFILGPMVGGYLTELDGGFYLTAFICSSVFVLNAGLVWLFPWTEVQPNAQNDGLGQGKNRALWGKSDSAVPAGTTAGDRTAGPPWGEVLATLQGLKSLTRPGLWDVYLMRLLMAVAVMLYHSNYVLALEERFEVRPRTAGYLISCSSALGALSGCALGPLLRLYSHSSQRVLLHSSALTSALLLLFSTARSVGVAVACSLLLAFSTSIGRTCLTDLQLTVGGGARAGGTLLGLGQSVTAVGRIIAPLLSGVAQELSPCGPPGLGAALALVAVVIMSLHRPHSGGDNRDAKLKRE", "length": 472 }, "evidence": [ { "id": "E1BAZ5", "url": "https://omabrowser.org/oma/group/E1BAZ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZTY6-1", "protein_name": "Major facilitator superfamily domain containing 9", "gene_name": "Slc67a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALGVRGRGASGQDLTSETPVTATASSSAVSSRRFLLWLYLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVFLLNAGLVWLLPWRETSLNIPDSGWSLDQKHATVTIKSESTLQGAATTPEARRSGRNLRPPWVEVMSTLKDMKNLIFSALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLGAALALVAILIMTLYRPPFSGDGSERLKRE", "length": 462 }, "evidence": [ { "id": "E1BAZ5", "url": "https://omabrowser.org/oma/group/E1BAZ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H6H8-1", "protein_name": "Major facilitator superfamily domain-containing protein 9 isoform X4", "gene_name": "Mfsd9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVVPLLSLHVKSLGVSPVVAGVVGSSYGALQLFSSTFVGCWSDVVGRRSSLLVCILLSALGYLLLGVSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPMVGGYLTELDGGFYMTAFICSSVFLLNAGLVWLLPWRETNLHSAENGWSLDQKHATAPRKSEGTLQGAATTPKVRWSEKKVQRPWVEVVSALKDMKSLIFSTLWDIFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSYMVLLHSSALTCLLLLLYSVASTMHVVVFSSTLLSFSTSIGRTCVTDLQLSAGGAQASGTVIGVGQSVTAVGRIIAPLLSGVAQEISPCGPPSLGAALALVAILIMSLNKPHSSGDGSKVLKRE", "length": 415 }, "evidence": [ { "id": "E1BAZ5", "url": "https://omabrowser.org/oma/group/E1BAZ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8C0T7-1", "protein_name": "Solute carrier family 67 member A2", "gene_name": "Slc67a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGVPGHGASRQDLASETPVTATAPSSAVSSRRFLLWLYLVGFLDLFGVSMVVPLLNLHVRSLGASPVVAGIVGSSYGVLQLFSSTFVGCWSDVVGRRSSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVVGGYLTELDGGFYVTAFICCSVFLLNAGLVWLLPWRETSLNIPDNGWSLDGKHTTEPIKSEGTLQGAATTSTARRSERTVQAPWVEVMLALKDMKNLIFSALWDVFLMRLLMGVAVMLYYSNFVLALEERFEVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSYMVLLHSSVLTCLLLVVYSTTCSMAMVVFSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGVAQEISPCGPPSLGAALALVAILIMTLNRPPFSGDGSERLKQE", "length": 466 }, "evidence": [ { "id": "E1BAZ5", "url": "https://omabrowser.org/oma/group/E1BAZ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NBP5-1", "protein_name": "Solute carrier family 67 member A2", "gene_name": "SLC67A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELGGHWDMNSAPRLVSETAERKQEQKTGTEAEAADSGAVGARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLLGRSHDTVQEAATSRRARASKKTAQPWVEVVLALRNMKNLLFSEMWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKRHSSGDGNSKLKSE", "length": 474 }, "evidence": [ { "id": "E1BAZ5", "url": "https://omabrowser.org/oma/group/E1BAZ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BAZ5", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "E1BAZ5", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 485, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAZ5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAZ5" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 475, "start_aa": "Phe", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB19-1", "uniprot_ac": "E1BB19", "uniprot_id": "E1BB19_BOVIN", "mass": { "chemical_mass": 21307.0, "monoisotopic_mass": 21307.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Serpin domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BB19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB19/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB19", "url": "https://www.uniprot.org/uniprotkb/E1BB19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1BB19", "locus": {} } ], "crossref": [ { "id": "E1BB19", "url": "https://alphafold.ebi.ac.uk/entry/E1BB19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005324", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005324", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BB19", "url": "https://www.uniprot.org/uniprotkb/E1BB19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB19-1", "url": "https://www.uniprot.org/uniprotkb/E1BB19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSLSTANVEFCLDVFKELNYNHAGDNVFFSLLSLLYALSMILLGARGTSAEPMEKVEKQLNSKTFQEWTSPPNMVERDVEVHLLRFKLEIKYELNSLLESLGMTDIFSQVKADLSGISPVKGLFVSKIIHKSYVEVNKEGTEAAAATGDILVVKRLPIRAQFVVNHPFLFFIKHFHTNTILLCGKLASP", "length": 190, "header": "tr|E1BB19-1|E1BB19_BOVIN Isoform 1 of Serpin domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=E1BB19-1" }, "isoforms": [ { "isoform_ac": "E1BB19-1", "url": "https://www.uniprot.org/uniprotkb/E1BB19/entry", "sequence": { "sequence": "MDSLSTANVEFCLDVFKELNYNHAGDNVFFSLLSLLYALSMILLGARGTSAEPMEKVEKQLNSKTFQEWTSPPNMVERDVEVHLLRFKLEIKYELNSLLESLGMTDIFSQVKADLSGISPVKGLFVSKIIHKSYVEVNKEGTEAAAATGDILVVKRLPIRAQFVVNHPFLFFIKHFHTNTILLCGKLASP", "length": 190, "header": "tr|E1BB19-1|E1BB19_BOVIN Isoform 1 of Serpin domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=E1BB19-1" }, "locus": { "chromosome": "24", "start_pos": 61973811, "end_pos": 61963198, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007006.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007006.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007006.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007006.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1BB19", "url": "https://www.uniprot.org/uniprotkb/E1BB19" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BB19", "url": "https://www.uniprot.org/uniprotkb/E1BB19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 190, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB19" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB19" }, { "id": "SM00093", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serpin", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 190, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB20-1", "uniprot_ac": "E1BB20", "uniprot_id": "E1BB20_BOVIN", "mass": { "chemical_mass": 5012.0, "monoisotopic_mass": 5012.0 }, "refseq": {}, "gene_names": [ { "name": "ASNSD1", "type": "recommended", "evidence": [ { "id": "E1BB20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB20" } ] } ], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "E1BB20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB20/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB20", "url": "https://www.uniprot.org/uniprotkb/E1BB20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASNSD1", "url": "https://www.uniprot.org/uniprotkb/E1BB20", "locus": { "chromosome": "2", "start_pos": 6665581, "end_pos": 6671724, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000492", "url": "https://www.ensembl.org/id/ENSBTAG00000000492" } ] } } ], "crossref": [ { "id": "E1BB20", "url": "https://alphafold.ebi.ac.uk/entry/E1BB20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000492", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000492", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR054148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF21975", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21975", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BB20", "url": "https://www.uniprot.org/uniprotkb/E1BB20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB20-1", "url": "https://www.uniprot.org/uniprotkb/E1BB20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSRGERPEDGAGPVPAESSTLHKEELSSKTEQKCFLKAKIHWMS", "length": 45, "header": "tr|E1BB20-1|E1BB20_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=ASNSD1 PE=4 SV=3 CANONICAL=E1BB20-1" }, "isoforms": [ { "isoform_ac": "E1BB20-1", "url": "https://www.uniprot.org/uniprotkb/E1BB20/entry", "sequence": { "sequence": "MPSRGERPEDGAGPVPAESSTLHKEELSSKTEQKCFLKAKIHWMS", "length": 45, "header": "tr|E1BB20-1|E1BB20_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=ASNSD1 PE=4 SV=3 CANONICAL=E1BB20-1" }, "locus": { "chromosome": "2", "start_pos": 6676359, "end_pos": 6671772, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056728.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056728.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052455.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052455.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB20-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 45, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB20-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB20" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB28-1", "uniprot_ac": "E1BB28", "uniprot_id": "E1BB28_BOVIN", "mass": { "chemical_mass": 100782.0, "monoisotopic_mass": 100782.0 }, "refseq": { "ac": "NP_001179970", "name": "sarcosine dehydrogenase, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179970" }, "gene_names": [ { "name": "SARDH", "type": "recommended", "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ] }, { "name": "SARDH", "type": "synonym", "evidence": [ { "id": "NP_001179970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179970" } ] } ], "protein_names": [ { "name": "Sarcosine dehydrogenase, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28/entry#names_and_taxonomy" } ] }, { "name": "1.5.8.3", "type": "synonym", "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28/entry#names_and_taxonomy" } ] }, { "name": "sarcosine dehydrogenase, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001179970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179970" } ] } ], "function": [ { "annotation": "Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine.", "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28#function" }, { "database": "UniProtKB", "id": "ARBA00059128", "url": "https://www.uniprot.org/uniprotkb/ARBA00059128#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SARDH", "url": "https://www.uniprot.org/uniprotkb/E1BB28", "locus": { "chromosome": "11", "start_pos": 104564521, "end_pos": 104581977, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004510", "url": "https://www.ensembl.org/id/ENSBTAG00000004510" } ] } } ], "crossref": [ { "id": "E1BB28", "url": "https://alphafold.ebi.ac.uk/entry/E1BB28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614603", "url": "https://www.ncbi.nlm.nih.gov/gene/614603", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614603", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BB28", "url": "https://www.orthodb.org/?gene=E1BB28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43757", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43757", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43757:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43757:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16350", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16350", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179970", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19793", "url": "https://www.rhea-db.org/rhea/19793", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB28-1", "url": "https://www.uniprot.org/uniprotkb/E1BB28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLSRALRGIAATRPRQSPARGWGLRPLVSGPGPTSEKSVPYQRTLKEAEDASAAAQGPSQPLPGTASVVVIGGGSLGCQTLYHLAKLGVSGAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSRELEEETGLHTGWIQNGGLFIASSQQRLDEYKRLMSLGRVYGIESHVLSPGETKALYPLMNVEDLYGTLYVPHDGTMDPAGTCTSLARAATTRGAQIIENCPVTGIRVRTDDFGVRRVAAVETEHGSIRTPCVINCAGVWARAVGRMAGVNVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYETNPIFCEEVSDEFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQQLAYWIVHGRPEKDMHSYDIRRFHRSLTGHGRWIRERSHEAYAKNYSVVFPHDEPLAGRNMRTGPLHEELRARGCVFQERHGWERPGWFSAQGPAPVLPYDYCGAYGHRAREDYAYGRLLGQEYTFSFPPHHDVIKKECLACRGAAAVFDMSYFGKFFLVGPDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPGPQASPLAPAFEGDGYYLAVGGAAAQHNWSHIRTVLQDRKFRCQLIDSSEDLGLISVQGPASRAVLQELLEADLSDDAFPFSTHKLVRAAGHLVRAVRLSFVGELGWELHAPRPSCLPVYQALMTAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRADDSPLEAGLAFTCKLKSSVPFLGREALEKQRAEGLRRRLVGFTVDEKVSMFGLEAIWRNGQVVGHVRRADFGFTINKTLAYGYIRDPSGGPVSLDFVKSGDYALERMGVTHAAQAHLKSPFDPDNKRVKGVY", "length": 919, "header": "tr|E1BB28-1|E1BB28_BOVIN Isoform 1 of Sarcosine dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=SARDH PE=3 SV=3 CANONICAL=E1BB28-1" }, "isoforms": [ { "isoform_ac": "E1BB28-1", "url": "https://www.uniprot.org/uniprotkb/E1BB28/entry", "sequence": { "sequence": "MASLSRALRGIAATRPRQSPARGWGLRPLVSGPGPTSEKSVPYQRTLKEAEDASAAAQGPSQPLPGTASVVVIGGGSLGCQTLYHLAKLGVSGAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSRELEEETGLHTGWIQNGGLFIASSQQRLDEYKRLMSLGRVYGIESHVLSPGETKALYPLMNVEDLYGTLYVPHDGTMDPAGTCTSLARAATTRGAQIIENCPVTGIRVRTDDFGVRRVAAVETEHGSIRTPCVINCAGVWARAVGRMAGVNVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYETNPIFCEEVSDEFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQQLAYWIVHGRPEKDMHSYDIRRFHRSLTGHGRWIRERSHEAYAKNYSVVFPHDEPLAGRNMRTGPLHEELRARGCVFQERHGWERPGWFSAQGPAPVLPYDYCGAYGHRAREDYAYGRLLGQEYTFSFPPHHDVIKKECLACRGAAAVFDMSYFGKFFLVGPDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPGPQASPLAPAFEGDGYYLAVGGAAAQHNWSHIRTVLQDRKFRCQLIDSSEDLGLISVQGPASRAVLQELLEADLSDDAFPFSTHKLVRAAGHLVRAVRLSFVGELGWELHAPRPSCLPVYQALMTAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRADDSPLEAGLAFTCKLKSSVPFLGREALEKQRAEGLRRRLVGFTVDEKVSMFGLEAIWRNGQVVGHVRRADFGFTINKTLAYGYIRDPSGGPVSLDFVKSGDYALERMGVTHAAQAHLKSPFDPDNKRVKGVY", "length": 919, "header": "tr|E1BB28-1|E1BB28_BOVIN Isoform 1 of Sarcosine dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=SARDH PE=3 SV=3 CANONICAL=E1BB28-1" }, "locus": { "chromosome": "11", "start_pos": 104579959, "end_pos": 104522844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005925.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005925.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005925.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005925.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 36, "start_aa": "Thr", "end_pos": 36, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr36", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614603", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614603", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798163", "resource": "Reactome", "description": "Choline catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sarcosine dehydrogenase activity", "id": "GO:0008480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008480", "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sarcosine catabolic process", "id": "GO:1901053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901053", "evidence": [ { "database": "UniProtKB", "id": "E1BB28", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 657, "end_pos": 659, "annotation": "n_glycosylation_sequon" }, { "start_pos": 863, "end_pos": 865, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19793", "name": "", "equation": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB28-1" ], "evidence": [ { "id": "19793", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19793" } ] }, { "id": "R-BTA-6797913", "name": "SARDH:FAD oxidatively demethylates SARC to Gly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-6797917", "R-ALL-9979086" ], "output_participant_list": [], "enzyme_list": [ "E1BB28-1" ], "evidence": [ { "id": "R-BTA-6797913", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6797913" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6797917", "participant_name": "SARC [mitochondrial matrix]", "crossref": [ { "id": "57433", "database": "ChEBI", "url": "" }, { "id": "ZINC000004658561", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9979086", "participant_name": "THFpolyGlu [mitochondrial matrix]", "crossref": [ { "id": "141005", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1BB28", "gene_name": "SARDH", "activity": [ { "ec_number": "1.5.8.3", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + glycine.", "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ] }, { "ec_number": "1.5.8.3", "activity": "", "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB28-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 919, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB28-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB28" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" }, { "id": "PF08669", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08669" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminomethyltransferase C-terminal", "eco_id": "ECO_0000259", "start_pos": 824, "end_pos": 908, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" }, { "id": "PF01266", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01266" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD dependent oxidoreductase", "eco_id": "ECO_0000259", "start_pos": 70, "end_pos": 428, "start_aa": "Val", "end_aa": "Trp", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" }, { "id": "PF16350", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16350" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD dependent oxidoreductase central", "eco_id": "ECO_0000259", "start_pos": 431, "end_pos": 486, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BB28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB28" }, { "id": "PF01571", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01571" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GCVT N-terminal", "eco_id": "ECO_0000259", "start_pos": 489, "end_pos": 803, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.5.8.3", "ec_name": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + glycine.", "evidence": [ { "id": "1.5.8.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.8.3" }, { "id": "1.5.8.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.8.3" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 36 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 468, "end_pos": 470 }, { "start_pos": 657, "end_pos": 659 }, { "start_pos": 863, "end_pos": 865 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB39-1", "uniprot_ac": "E1BB39", "uniprot_id": "E1BB39_BOVIN", "mass": { "chemical_mass": 132473.0, "monoisotopic_mass": 132473.0 }, "refseq": {}, "gene_names": [ { "name": "VWA5B1", "type": "recommended", "evidence": [ { "id": "E1BB39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB39" } ] } ], "protein_names": [ { "name": "von Willebrand factor A domain containing 5B1", "type": "synonym", "evidence": [ { "id": "E1BB39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB39/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB39", "url": "https://www.uniprot.org/uniprotkb/E1BB39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VWA5B1", "url": "https://www.uniprot.org/uniprotkb/E1BB39", "locus": { "chromosome": "2", "start_pos": 132261278, "end_pos": 132314628, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013511", "url": "https://www.ensembl.org/id/ENSBTAG00000013511" } ] } } ], "crossref": [ { "id": "E1BB39", "url": "https://alphafold.ebi.ac.uk/entry/E1BB39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013511", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013511", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01461", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01461", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46299", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46299", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46299:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46299:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13757", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13757", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13768", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13768", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BB39", "url": "https://www.uniprot.org/uniprotkb/E1BB39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB39-1", "url": "https://www.uniprot.org/uniprotkb/E1BB39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGLLNQITGAALPLTASDVTSFVSGYALGLTASLTYGNLEAQPFQGLFVYPLDEHTTVIGFEAVIGDRVVTVQIKDKAKIEGGHFEATGIRAATVTGTILQSIIPPSCQPGKVALDEDLERILFVVNLGTIAPMENVFVFISTSSELPTLPSGAVRVQLPAVCAPTVPQFCTESTGAPSQQVHGRDKHCFGSLDSWNRLCLSTLLDTDVSNPMEYEFNFQLEIRGPCLLAGVESPTHEIRADAAPSASSAESIIVTLANRHTFDRPVEILIHPSEPHLPHVLMEKGDMTLGEFDQHLKGRADFIKGMKKDSSAERKTEIIRKRLHKDIPHHSVIMLNFCPDLQSVQPNLRKTRGEFIFLVDRSGSMNGTNIQCVKDAMLVALKSLVPTCLFNVIGFGSTFKTLFPSSQTYNEENLAMACDSIQKMRADMGGTNILSPLKWVTRQPVLRGCPRLLFLITDGAVNNTGKVLELVRNHAFSTRCYSFGIGPNVCHRLVKGLATVSKGSAEFLEEGERLQPKMVKSLKKAMAPVLSDVTVEWVFPETTEVLISPVSTSSLFPGERLVGYGIVCDASLYISNPRTDKRRRYSMLHSQESGSSVFYHSQDEEPNPDSGDCVRSVGAPFNPRQAKDAQPSSGDATPNPGLDLSQRRRAYSTNQITNHKPTPRTLIASDPTTATRRYPLRKTKLQDLTNQTSLDAPWWQIDLQPLLNGGPDLSQGPKLRGPGARRPSLLPQGCQPFLPSNQETQAWSPMKELASESRSPGDLEPSHHPSAFATETSSDWEPLAESEERASPSRPATPGPVLGKAVVKGLRDSQHLQWEVSFELGPPGPERGGAQEPDLWSETFHHLAARAIIRDFEQLAEREGEIEQGSSRRYQVNAVHTSKACNVISKYTAFVPVDINKSRYLPTVVGYPNSAALRMVSSRVLTRQWKGTSGFGRSQTMLGEDSAAGDSKYQNLNVEESTLTPFSESMAREKYATLEGPLRGLATNTVSSLKASDTLFGSRLSLNKSRLLTRAAKGFLGKPLTKTPDSAQGNQSSDYIPLVSLQLASGAFLLNQAFCEAIHVPMEKLKWTSPFTCHRVSLTTRQPPSPQPCTSPAPLHPSRDGLSQEPLAEGRPGQEPRAVVEHMGKMWATVVALAWLEHSSASYFVEWELVAAKASSWLEQQEVPEGRTQGTLKAAARQLFVLLRHWDENLEFNMLCYNPNYV", "length": 1208, "header": "tr|E1BB39-1|E1BB39_BOVIN Isoform 1 of von Willebrand factor A domain containing 5B1 OS=Bos taurus OX=9913 GN=VWA5B1 PE=4 SV=4 CANONICAL=E1BB39-1" }, "isoforms": [ { "isoform_ac": "E1BB39-1", "url": "https://www.uniprot.org/uniprotkb/E1BB39/entry", "sequence": { "sequence": "MPGLLNQITGAALPLTASDVTSFVSGYALGLTASLTYGNLEAQPFQGLFVYPLDEHTTVIGFEAVIGDRVVTVQIKDKAKIEGGHFEATGIRAATVTGTILQSIIPPSCQPGKVALDEDLERILFVVNLGTIAPMENVFVFISTSSELPTLPSGAVRVQLPAVCAPTVPQFCTESTGAPSQQVHGRDKHCFGSLDSWNRLCLSTLLDTDVSNPMEYEFNFQLEIRGPCLLAGVESPTHEIRADAAPSASSAESIIVTLANRHTFDRPVEILIHPSEPHLPHVLMEKGDMTLGEFDQHLKGRADFIKGMKKDSSAERKTEIIRKRLHKDIPHHSVIMLNFCPDLQSVQPNLRKTRGEFIFLVDRSGSMNGTNIQCVKDAMLVALKSLVPTCLFNVIGFGSTFKTLFPSSQTYNEENLAMACDSIQKMRADMGGTNILSPLKWVTRQPVLRGCPRLLFLITDGAVNNTGKVLELVRNHAFSTRCYSFGIGPNVCHRLVKGLATVSKGSAEFLEEGERLQPKMVKSLKKAMAPVLSDVTVEWVFPETTEVLISPVSTSSLFPGERLVGYGIVCDASLYISNPRTDKRRRYSMLHSQESGSSVFYHSQDEEPNPDSGDCVRSVGAPFNPRQAKDAQPSSGDATPNPGLDLSQRRRAYSTNQITNHKPTPRTLIASDPTTATRRYPLRKTKLQDLTNQTSLDAPWWQIDLQPLLNGGPDLSQGPKLRGPGARRPSLLPQGCQPFLPSNQETQAWSPMKELASESRSPGDLEPSHHPSAFATETSSDWEPLAESEERASPSRPATPGPVLGKAVVKGLRDSQHLQWEVSFELGPPGPERGGAQEPDLWSETFHHLAARAIIRDFEQLAEREGEIEQGSSRRYQVNAVHTSKACNVISKYTAFVPVDINKSRYLPTVVGYPNSAALRMVSSRVLTRQWKGTSGFGRSQTMLGEDSAAGDSKYQNLNVEESTLTPFSESMAREKYATLEGPLRGLATNTVSSLKASDTLFGSRLSLNKSRLLTRAAKGFLGKPLTKTPDSAQGNQSSDYIPLVSLQLASGAFLLNQAFCEAIHVPMEKLKWTSPFTCHRVSLTTRQPPSPQPCTSPAPLHPSRDGLSQEPLAEGRPGQEPRAVVEHMGKMWATVVALAWLEHSSASYFVEWELVAAKASSWLEQQEVPEGRTQGTLKAAARQLFVLLRHWDENLEFNMLCYNPNYV", "length": 1208, "header": "tr|E1BB39-1|E1BB39_BOVIN Isoform 1 of von Willebrand factor A domain containing 5B1 OS=Bos taurus OX=9913 GN=VWA5B1 PE=4 SV=4 CANONICAL=E1BB39-1" }, "locus": { "chromosome": "2", "start_pos": 132314628, "end_pos": 132262282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017965.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017965.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017965.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017965.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 799, "start_aa": "Thr", "end_pos": 799, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr799", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1009, "end_pos": 1011, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1036, "end_pos": 1038, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB39-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1208, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB39-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB39" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB39" }, { "id": "PS51468", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51468" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VIT", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 146, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BB39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB39" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 356, "end_pos": 524, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 799 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1009, "end_pos": 1011 }, { "start_pos": 1036, "end_pos": 1038 }, { "start_pos": 368, "end_pos": 370 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 692, "end_pos": 694 }, { "start_pos": 902, "end_pos": 904 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB44-1", "uniprot_ac": "E1BB44", "uniprot_id": "E1BB44_BOVIN", "mass": { "chemical_mass": 43262.0, "monoisotopic_mass": 43262.0 }, "refseq": { "ac": "NP_001192893", "name": "microfibrillar-associated protein 3-like precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192893" }, "gene_names": [ { "name": "MFAP3L", "type": "recommended", "evidence": [ { "id": "E1BB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB44" } ] }, { "name": "MFAP3L", "type": "synonym", "evidence": [ { "id": "NP_001192893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192893" } ] } ], "protein_names": [ { "name": "Microfibrillar-associated protein 3-like", "type": "recommended", "evidence": [ { "id": "E1BB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB44/entry#names_and_taxonomy" } ] }, { "name": "microfibrillar associated protein 3 like", "type": "synonym", "evidence": [ { "id": "NP_001192893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192893" } ] }, { "name": "microfibrillar-associated protein 3-like precursor", "type": "synonym", "evidence": [ { "id": "NP_001192893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192893" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB44", "url": "https://www.uniprot.org/uniprotkb/E1BB44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFAP3L", "url": "https://www.uniprot.org/uniprotkb/E1BB44", "locus": { "chromosome": "8", "start_pos": 1831164, "end_pos": 1879263, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019539", "url": "https://www.ensembl.org/id/ENSBTAG00000019539" } ] } } ], "crossref": [ { "id": "E1BB44", "url": "https://alphafold.ebi.ac.uk/entry/E1BB44", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019539", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019539", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529443", "url": "https://www.ncbi.nlm.nih.gov/gene/529443", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529443", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529443", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVLIDCN", "url": "https://omabrowser.org/oma/group/CVLIDCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BB44", "url": "https://www.orthodb.org/?gene=E1BB44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14340:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14340:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BB44", "url": "https://www.uniprot.org/uniprotkb/E1BB44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB44-1", "url": "https://www.uniprot.org/uniprotkb/E1BB44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGVKRHLPVCFLPPVPLLILVSTLATASSVTSSTLNGTNVAVGLAPVVVARTDHIIVKEGNSALINCSVSGLPEPQFKWYNSAGKLLSENEEDQGGGKWQMHDGLLNITKVSFSDRGRYTCMASNVHGSVNNTVTLRVVFTSGDMGVYYMVVCLVAFAVVLVLNVTRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIVEELMEVVGLDEHGHQNFVRHTPEGQEAAAADGDEVYTIPDADSDASSLHEQPQQIAIEVSVHPPAHREPSDDRAAGALEAGDEEDTEPSAEHSPESAAPSTEVTSAALTSEEPTPVEVPDHVLPPGLLEAAEPARPRDGSTHVVYESHV", "length": 400, "header": "tr|E1BB44-1|E1BB44_BOVIN Isoform 1 of Microfibrillar-associated protein 3-like OS=Bos taurus OX=9913 GN=MFAP3L PE=4 SV=1 CANONICAL=E1BB44-1" }, "isoforms": [ { "isoform_ac": "E1BB44-1", "url": "https://www.uniprot.org/uniprotkb/E1BB44/entry", "sequence": { "sequence": "MDGVKRHLPVCFLPPVPLLILVSTLATASSVTSSTLNGTNVAVGLAPVVVARTDHIIVKEGNSALINCSVSGLPEPQFKWYNSAGKLLSENEEDQGGGKWQMHDGLLNITKVSFSDRGRYTCMASNVHGSVNNTVTLRVVFTSGDMGVYYMVVCLVAFAVVLVLNVTRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIVEELMEVVGLDEHGHQNFVRHTPEGQEAAAADGDEVYTIPDADSDASSLHEQPQQIAIEVSVHPPAHREPSDDRAAGALEAGDEEDTEPSAEHSPESAAPSTEVTSAALTSEEPTPVEVPDHVLPPGLLEAAEPARPRDGSTHVVYESHV", "length": 400, "header": "tr|E1BB44-1|E1BB44_BOVIN Isoform 1 of Microfibrillar-associated protein 3-like OS=Bos taurus OX=9913 GN=MFAP3L PE=4 SV=1 CANONICAL=E1BB44-1" }, "locus": { "chromosome": "8", "start_pos": 1847079, "end_pos": 1832168, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026034.4", "url": "https://www.ensembl.org/id/ENSBTAT00000026034.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026034.2", "url": "https://www.ensembl.org/id/ENSBTAP00000026034.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 365, "start_aa": "Thr", "end_pos": 365, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr365", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529443", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529443", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C9G1-1", "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "MFAP3L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNILNRHHFLCFLPTIRLVILLAALTTAEDVTNSTFNRTGTNTGSVPVVISHIDHIIVKEGCSALIDCNVQGSPSPHYRWYNSNGRLLQEEENKAGKWWFLENGLLNITSVSFEDRGKYTCVASNMYGSVNNTVTLRVVFTSGDMGIYYMIVCLVAFTIVMILNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRQTAEGQETTETDELYTIPNALKRSDSPTADSDASSLHEPPQQIAIKVSVHPLSKKDCMDGQSQESVQLDTKEEDLPQTPALPTEPSPEPSTELSSDDTALANDTCVIYESHV", "length": 380 }, "evidence": [ { "id": "E1BB44", "url": "https://omabrowser.org/oma/group/E1BB44/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F6P5-1", "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "mfap3l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSHCYREPLKMKRVNGYVIIYLASVISFCAAGALNITAVDGEGGENRTEANGAGSIPVVVTKTSQIIAREGNCALIDCNVTGDPFPNVQWFNSHGHLLDTKKSDGKWWILDSGVLNITSITFADRGKYTCVASNSHGTANCTVTLRVVFTNGDMGVYYMVVCLVTFTIIMILNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSIPLPPLIMNCRTFMEEILEVVGVEEMRHTFVRQAPESLDGHGAVAASNPADVFTILRERERSESPAADSDDASLHEQPQHIAIQVSVHPQLTSPGCCNIEAPPLSEIGSTSPPPLAQLPLVEESVEQENKEESVQEGGATKKTQVIYESHV", "length": 397 }, "evidence": [ { "id": "E1BB44", "url": "https://omabrowser.org/oma/group/E1BB44/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O75121-1", "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "MFAP3L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRLKSHLTVCFLPSVPFLILVSTLATAKSVTNSTLNGTNVVLGSVPVIIARTDHIIVKEGNSALINCSVYGIPDPQFKWYNSIGKLLKEEEDEKERGGGKWQMHDSGLLNITKVSFSDRGKYTCVASNIYGTVNNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMVLNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAADRDEVYTIPNSLKRSDSPAADSDASSLHEQPQQIAIKVSVHPQSKKEHADDQEGGQFEVKDVEETELSAEHSPETAEPSTDVTSTELTSEEPTPVEVPDKVLPPAYLEATEPAVTHDKNTCIIYESHV", "length": 409 }, "evidence": [ { "id": "E1BB44", "url": "https://omabrowser.org/oma/group/E1BB44/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AYP2-1", "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "Mfap3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLLKSHLTVCLPPSVPFLILVSTLATAKSVTNSTLNGTDVVLGSVPVIIARTDHIIVKEGNSALINCSAFGIPDLEYKWYNSVGKLLKEMDDEKERGGGKWQMLDGGLLNITKVSFSDRGKYTCVASNIYGTINNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMILNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAPDRDEVYTIPNSLKRSESPTADSDASSLHEQPQQIAIKVSVHPQSKKDHVDDQEGENLEVKDEEETEPSEEHSPETAEPSTDITTTELTSEEASPVEAPERELPPAHLETTEPAVTCDRNTCIIYESHV", "length": 409 }, "evidence": [ { "id": "E1BB44", "url": "https://omabrowser.org/oma/group/E1BB44/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D3X9-1", "protein_name": "Microfibrillar-associated protein 3-like", "gene_name": "Mfap3l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLQKSHLTVCLPPSVPFLILVSTLATAKSVTNSTLNGTDVVLGSVPVIIARTDHIIVKEGSSALINCSAYGFPDLEFKWYNSVGKLLKEMDDEKEKGGGKWQMLDGGLLNITKVSFSDRGKYTCVASNIYGTINNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMILNITRLCMMSSHLKKTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARSVPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAPDRDEVYTIPNSLKRSESPTADSDASSLHEQPQQIAIKVSVHPQSKRDHVDDQEGGHFEVKDEEETEPSEEHSPETAEPSTDITTTELTSEETSPVEAPERGLPPAHLETTEPAVTCDRNTCIIYESHV", "length": 409 }, "evidence": [ { "id": "E1BB44", "url": "https://omabrowser.org/oma/group/E1BB44/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BB44", "url": "https://www.uniprot.org/uniprotkb/E1BB44" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB44", "url": "https://www.uniprot.org/uniprotkb/E1BB44" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BB44", "url": "https://www.uniprot.org/uniprotkb/E1BB44" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "E1BB44", "url": "https://www.uniprot.org/uniprotkb/E1BB44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB44-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB44-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB44" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB44" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 138, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 365 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB51-1", "uniprot_ac": "E1BB51", "uniprot_id": "E1BB51_BOVIN", "mass": { "chemical_mass": 36970.0, "monoisotopic_mass": 36970.0 }, "refseq": { "ac": "XP_015328900", "name": "C-type lectin domain family 4 member K", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328900" }, "gene_names": [ { "name": "CD207", "type": "recommended", "evidence": [ { "id": "E1BB51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ] }, { "name": "CD207", "type": "synonym", "evidence": [ { "id": "XP_015328900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328900" } ] } ], "protein_names": [ { "name": "C-type lectin domain family 4 member K", "type": "recommended", "evidence": [ { "id": "E1BB51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB51/entry#names_and_taxonomy" } ] }, { "name": "C-type lectin domain family 4 member K", "type": "synonym", "evidence": [ { "id": "XP_015328900", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328900" } ] }, { "name": "Langerin", "type": "synonym", "evidence": [ { "id": "E1BB51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB51/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD207", "url": "https://www.uniprot.org/uniprotkb/E1BB51", "locus": { "chromosome": "11", "start_pos": 13564747, "end_pos": 13548576, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004562", "url": "https://www.ensembl.org/id/ENSBTAG00000004562" } ] } } ], "crossref": [ { "id": "E1BB51", "url": "https://alphafold.ebi.ac.uk/entry/E1BB51", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004562", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004562", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511000", "url": "https://www.ncbi.nlm.nih.gov/gene/511000", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BB51", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BB51*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511000", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511000", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WYSAEQF", "url": "https://omabrowser.org/oma/group/WYSAEQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BB51", "url": "https://www.orthodb.org/?gene=E1BB51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1236978", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015328900", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328900", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB51-1", "url": "https://www.uniprot.org/uniprotkb/E1BB51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTADSEVLDAHFTVDKQNVSLWPPDPPPKTCPSQVLGRLLTVRAVVIFLMLVTITSVLLQAILYPWFMGTISDVKTNAQLLKGRVDNISSLSSEIKRNRGGLVAVGIQVRMVNASLDRISSQIRRLETGLKEASAQLQVLTSSWKAVDELNAQIPELKQDLDKASALNAKVRELQSGLESISKLLQQQKDILQVVSQGWKYFGGHFYYFSKISKTWYSAQQICISRDSHLTSVTSEREQEFLYRTAGGLPYWIGLTKAGSEGDWHWVDGTPYNKVQSEKFWIPGEPNNVGNNEHCVTLKTSLLRSWNDASCDNTFLFICKRSYKPSEP", "length": 329, "header": "tr|E1BB51-1|E1BB51_BOVIN Isoform 1 of C-type lectin domain family 4 member K OS=Bos taurus OX=9913 GN=CD207 PE=4 SV=3 CANONICAL=E1BB51-1" }, "isoforms": [ { "isoform_ac": "E1BB51-1", "url": "https://www.uniprot.org/uniprotkb/E1BB51/entry", "sequence": { "sequence": "MKTADSEVLDAHFTVDKQNVSLWPPDPPPKTCPSQVLGRLLTVRAVVIFLMLVTITSVLLQAILYPWFMGTISDVKTNAQLLKGRVDNISSLSSEIKRNRGGLVAVGIQVRMVNASLDRISSQIRRLETGLKEASAQLQVLTSSWKAVDELNAQIPELKQDLDKASALNAKVRELQSGLESISKLLQQQKDILQVVSQGWKYFGGHFYYFSKISKTWYSAQQICISRDSHLTSVTSEREQEFLYRTAGGLPYWIGLTKAGSEGDWHWVDGTPYNKVQSEKFWIPGEPNNVGNNEHCVTLKTSLLRSWNDASCDNTFLFICKRSYKPSEP", "length": 329, "header": "tr|E1BB51-1|E1BB51_BOVIN Isoform 1 of C-type lectin domain family 4 member K OS=Bos taurus OX=9913 GN=CD207 PE=4 SV=3 CANONICAL=E1BB51-1" }, "locus": { "chromosome": "11", "start_pos": 13563743, "end_pos": 13559665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005993.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005993.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005993.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005993.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511000", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511000", "resource": "KEGG Pathway" }, { "id": "R-BTA-1236978", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "resource": "Reactome", "description": "Cross-presentation of soluble exogenous antigens (endosomes)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JYC8-1", "protein_name": "C-type lectin domain family 4 member K", "gene_name": "LOC100757258", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPEVKMKESEAPDAHFTVDKQNISLWPREPPPKPDLSPVLRKPLSLRVAFICLSLVLVASIVLQAVFYPRLVDKILDVKSDAQMLRDRADNISSLGSVLEKDRGRVEEAEVQIQILNTSLTRARSQILSLRIIMEQASAQISVLTRNWEEVDSLSSKIPELQRDLDKSSALNAKVRGLQNSLENVNKLLQRQSDILEMVSRGWKYFGGNLYYFSYTPKTWYSAEQSCISRDAHLTSVTSESEQEFLYKSADRLPCWIGLTKAGTEGHWYWVDGTLFNKEQSKRFWIPGEPNNTGNNEHCGNIRVSSLQAWNDASCDSKFPFICKRPFIQAIP", "length": 332 }, "evidence": [ { "id": "E1BB51", "url": "https://omabrowser.org/oma/group/E1BB51/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZBX0-1", "protein_name": "C-type lectin domain family 4 member K", "gene_name": "Cd207", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEVEMKETEVPDAHFTVDKQNISLWPREPPPKQDLTPVLRKPHCICAAFICLALVLVTSIVLQAVFYPRLMGKILDVKSDAQMLRGRVDNISTLGSDLKRERGRVDDAEVQMRIVNTSLGRVRSKILSLEASMKIVSNQLQVLTMNWGEVDNLNAKIPELQKDLDKASALNTKVQGLQNSLENINKLLKEQSDILEMMSRGWKYFMGNFYYFSRTPKTWYSAEQYCISRKAHLTSVSSESEHEFLYKVADGIPHWIGLTKAGSEGDWYWVDQTSFNKEQSRRFWIPGEPNNVRNNEHCANIRVSALKCWNDSPCDNVYSFICKMPYIRMIT", "length": 332 }, "evidence": [ { "id": "E1BB51", "url": "https://omabrowser.org/oma/group/E1BB51/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VBX4-1", "protein_name": "C-type lectin domain family 4 member K", "gene_name": "Cd207", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPEAEMKEEAPEAHFTVDKQNISLWPREPPPKQDLSPVLRKPLCICVAFTCLALVLVTSIVLQAVFYPRLMGKILDVKSDAQMLKGRVDNISTLGSDLKTERGRVDDAEVQMQIVNTTLKRVRSQILSLETSMKIANDQLQILTMSWGEVDSLSAKIPELKRDLDKASALNTKVQGLQNSLENVNKLLKQQSDILEMVARGWKYFSGNFYYFSRTPKTWYSAEQFCISRKAHLTSVSSESEQKFLYKAADGIPHWIGLTKAGSEGDWYWVDQTSFNKEQSRRFWIPGEPNNAGNNEHCANIRVSALKCWNDGPCDNTFLFICKRPYVQTTE", "length": 331 }, "evidence": [ { "id": "E1BB51", "url": "https://omabrowser.org/oma/group/E1BB51/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJ71-1", "protein_name": "C-type lectin domain family 4 member K", "gene_name": "CD207", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQAVLYPRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQSVRFWIPGEPNNAGNNEHCGNIKAPSLQAWNDAPCDKTFLFICKRPYVPSEP", "length": 328 }, "evidence": [ { "id": "E1BB51", "url": "https://omabrowser.org/oma/group/E1BB51/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "E1BB51", "url": "https://www.uniprot.org/uniprotkb/E1BB51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB51-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 329, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB51-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB51" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB51" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 321, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BB66-1", "uniprot_ac": "E1BB66", "uniprot_id": "E1BB66_BOVIN", "mass": { "chemical_mass": 60492.0, "monoisotopic_mass": 60492.0 }, "refseq": { "ac": "XP_002699386", "name": "solute carrier family 22 member 20", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699386" }, "gene_names": [ { "name": "SLC22A20", "type": "recommended", "evidence": [ { "id": "E1BB66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB66" } ] }, { "name": "SLC22A20", "type": "synonym", "evidence": [ { "id": "XP_002699386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699386" } ] } ], "protein_names": [ { "name": "Major facilitator superfamily (MFS) profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BB66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB66/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 22 member 20", "type": "synonym", "evidence": [ { "id": "XP_002699386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699386" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB66", "url": "https://www.uniprot.org/uniprotkb/E1BB66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC22A20", "url": "https://www.uniprot.org/uniprotkb/E1BB66", "locus": {} } ], "crossref": [ { "id": "E1BB66", "url": "https://alphafold.ebi.ac.uk/entry/E1BB66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010233", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010233", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526596", "url": "https://www.ncbi.nlm.nih.gov/gene/526596", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526596", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526596", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002699386", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699386", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BB66", "url": "https://www.uniprot.org/uniprotkb/E1BB66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB66-1", "url": "https://www.uniprot.org/uniprotkb/E1BB66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFTDLLDALGGVGRFQLVSTALLLLPCSLLACHNFLQNFTAAVPPHHCQSPANHSAAAVYGSGAWLRATVPLHPLGLPEPCRRFTRPQWALLSPNASVDGAATEGCKDGWVYDRSVFPSTIVTEWDLVCEARTLRDLAQSAYMAGVLAGAAVFGSLADRLGRKAPLVWSYLQLAVSGAATAYFSSFGTYCFCRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGYSFTSGQLILAGVAYLIRPWRWLQFAVSVPFLIFFLYSWWLPESSRWLLLHGKTQVALKNLRKVAAMNGRKEEGERLTKEVVSSYIQSEFAAGRPSNSVLDLFRTPAIRKVTCCLMVVWFSNSLAYYGLAMDLQKFGLSVYLVQVLFGVIDIPAMLVATTTMIYVGRRATVASFLILAGLMVISNMFVPEDMQSLRTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVNARLGGLAAPLLTMLGEFSAVLPPVGFGAPSILAGLAVCFLAETRDVPLVETIEAMERRVKERLSRNDAEEKGEEVSLQQLGVSPLKETI", "length": 555, "header": "tr|E1BB66-1|E1BB66_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=SLC22A20 PE=4 SV=4 CANONICAL=E1BB66-1" }, "isoforms": [ { "isoform_ac": "E1BB66-1", "url": "https://www.uniprot.org/uniprotkb/E1BB66/entry", "sequence": { "sequence": "MAFTDLLDALGGVGRFQLVSTALLLLPCSLLACHNFLQNFTAAVPPHHCQSPANHSAAAVYGSGAWLRATVPLHPLGLPEPCRRFTRPQWALLSPNASVDGAATEGCKDGWVYDRSVFPSTIVTEWDLVCEARTLRDLAQSAYMAGVLAGAAVFGSLADRLGRKAPLVWSYLQLAVSGAATAYFSSFGTYCFCRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGYSFTSGQLILAGVAYLIRPWRWLQFAVSVPFLIFFLYSWWLPESSRWLLLHGKTQVALKNLRKVAAMNGRKEEGERLTKEVVSSYIQSEFAAGRPSNSVLDLFRTPAIRKVTCCLMVVWFSNSLAYYGLAMDLQKFGLSVYLVQVLFGVIDIPAMLVATTTMIYVGRRATVASFLILAGLMVISNMFVPEDMQSLRTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVNARLGGLAAPLLTMLGEFSAVLPPVGFGAPSILAGLAVCFLAETRDVPLVETIEAMERRVKERLSRNDAEEKGEEVSLQQLGVSPLKETI", "length": 555, "header": "tr|E1BB66-1|E1BB66_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=SLC22A20 PE=4 SV=4 CANONICAL=E1BB66-1" }, "locus": { "chromosome": "29", "start_pos": 43450820, "end_pos": 43428887, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013515.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013515.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013515.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013515.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526596", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526596", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BB66", "url": "https://www.uniprot.org/uniprotkb/E1BB66" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "E1BB66", "url": "https://www.uniprot.org/uniprotkb/E1BB66" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "organic anion transport", "id": "GO:0015711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015711", "evidence": [ { "database": "UniProtKB", "id": "E1BB66", "url": "https://www.uniprot.org/uniprotkb/E1BB66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB66-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 555, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB66-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB66" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB66" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 511, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 39, "end_pos": 41 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBA8-1", "uniprot_ac": "E1BBA8", "uniprot_id": "E1BBA8_BOVIN", "mass": { "chemical_mass": 23897.0, "monoisotopic_mass": 23897.0 }, "refseq": {}, "gene_names": [ { "name": "LY6G5B", "type": "recommended", "evidence": [ { "id": "E1BBA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA8" } ] } ], "protein_names": [ { "name": "Lymphocyte antigen 6 family member G5B", "type": "synonym", "evidence": [ { "id": "E1BBA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBA8", "url": "https://www.uniprot.org/uniprotkb/E1BBA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LY6G5B", "url": "https://www.uniprot.org/uniprotkb/E1BBA8", "locus": { "chromosome": "23", "start_pos": 27627266, "end_pos": 27629204, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039740", "url": "https://www.ensembl.org/id/ENSBTAG00000039740" } ] } } ], "crossref": [ { "id": "E1BBA8", "url": "https://alphafold.ebi.ac.uk/entry/E1BBA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039740", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039740", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23544", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23544", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BBA8", "url": "https://www.orthodb.org/?gene=E1BBA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14313", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14313", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14313:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14313:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BBA8", "url": "https://www.uniprot.org/uniprotkb/E1BBA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBA8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRWGFWAPLRDCPSPQKSMMKAHMLIGALVMVGFTVGKAPVSEVRTCHLCLLENPAVGCISGSEKCTISSSSPCMVISINYENKARFLIRGCGQHNSYRCQEKLPTYISEYWYSAQCCQYDYCNSWYSPQLQSASPEPLDRSLALPLSQSQILWFYQTLNLSLPLPSFPAGKEPSEGLDPLAGPPMNLSLSIADLRSIYLFLNSSGLLTLPWAGP", "length": 216, "header": "tr|E1BBA8-1|E1BBA8_BOVIN Isoform 1 of Lymphocyte antigen 6 family member G5B OS=Bos taurus OX=9913 GN=LY6G5B PE=4 SV=2 CANONICAL=E1BBA8-1" }, "isoforms": [ { "isoform_ac": "E1BBA8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBA8/entry", "sequence": { "sequence": "MGRWGFWAPLRDCPSPQKSMMKAHMLIGALVMVGFTVGKAPVSEVRTCHLCLLENPAVGCISGSEKCTISSSSPCMVISINYENKARFLIRGCGQHNSYRCQEKLPTYISEYWYSAQCCQYDYCNSWYSPQLQSASPEPLDRSLALPLSQSQILWFYQTLNLSLPLPSFPAGKEPSEGLDPLAGPPMNLSLSIADLRSIYLFLNSSGLLTLPWAGP", "length": 216, "header": "tr|E1BBA8-1|E1BBA8_BOVIN Isoform 1 of Lymphocyte antigen 6 family member G5B OS=Bos taurus OX=9913 GN=LY6G5B PE=4 SV=2 CANONICAL=E1BBA8-1" }, "locus": { "chromosome": "23", "start_pos": 27629005, "end_pos": 27627936, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055070.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055070.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049587.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049587.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BBA8", "url": "https://www.uniprot.org/uniprotkb/E1BBA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BBA8", "url": "https://www.uniprot.org/uniprotkb/E1BBA8" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BBA8", "url": "https://www.uniprot.org/uniprotkb/E1BBA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 216, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBA8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBA8" }, { "id": "PF00021", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UPAR/Ly6", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 126, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 204, "end_pos": 206 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBC7-1", "uniprot_ac": "E1BBC7", "uniprot_id": "E1BBC7_BOVIN", "mass": { "chemical_mass": 35186.0, "monoisotopic_mass": 35186.0 }, "refseq": { "ac": "NP_001376851", "name": "olfactory receptor family 10 subfamily X member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376851" }, "gene_names": [ { "name": "OR10X1", "type": "recommended", "evidence": [ { "id": "E1BBC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC7" } ] }, { "name": "OR10X1", "type": "synonym", "evidence": [ { "id": "NP_001376851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376851" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 10 subfamily X member 1", "type": "synonym", "evidence": [ { "id": "E1BBC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC7/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10X1", "type": "synonym", "evidence": [ { "id": "NP_001376851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376851" } ] }, { "name": "olfactory receptor family 10 subfamily X member 1", "type": "synonym", "evidence": [ { "id": "NP_001376851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376851" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376851" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BBC7", "url": "https://www.uniprot.org/uniprotkb/E1BBC7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBC7", "url": "https://www.uniprot.org/uniprotkb/E1BBC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10X1", "url": "https://www.uniprot.org/uniprotkb/E1BBC7", "locus": { "chromosome": "3", "start_pos": 11126897, "end_pos": 11125947, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039653", "url": "https://www.ensembl.org/id/ENSBTAG00000039653" } ] } } ], "crossref": [ { "id": "E1BBC7", "url": "https://alphafold.ebi.ac.uk/entry/E1BBC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513494", "url": "https://www.ncbi.nlm.nih.gov/gene/513494", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513494", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513494", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376851", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBC7", "url": "https://www.uniprot.org/uniprotkb/E1BBC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMKINQTVLKEFILVGFSVYPHAQTFLFVVFFCLYLPTLTGNLAIMGLTWVDRRLHTPMYLFLSALSSSETCYTLTIIPKMLSDLLAKDRSISSIGCGLQMCFFLGLGGTNCAILTWMGYDRFLAICNPLRYPLLMTNMVCGKCVASAWIAGFFVSVIETALIFRGSFCNPNLVKHFFCHMRAVVRLSCLDSDLTEFTVTVMSVSGLMGTFLVIILTYVFILSTVLKIPSAEGKQKAFSTCASHLTVVIIHFGFASIVYLKPEASGGDDTVIAVPYTVVTPFLSPLIFSLRNKDMKNAFRKILRNFLNNLVLSLHN", "length": 316, "header": "tr|E1BBC7-1|E1BBC7_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily X member 1 OS=Bos taurus OX=9913 GN=OR10X1 PE=3 SV=4 CANONICAL=E1BBC7-1" }, "isoforms": [ { "isoform_ac": "E1BBC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC7/entry", "sequence": { "sequence": "MMKINQTVLKEFILVGFSVYPHAQTFLFVVFFCLYLPTLTGNLAIMGLTWVDRRLHTPMYLFLSALSSSETCYTLTIIPKMLSDLLAKDRSISSIGCGLQMCFFLGLGGTNCAILTWMGYDRFLAICNPLRYPLLMTNMVCGKCVASAWIAGFFVSVIETALIFRGSFCNPNLVKHFFCHMRAVVRLSCLDSDLTEFTVTVMSVSGLMGTFLVIILTYVFILSTVLKIPSAEGKQKAFSTCASHLTVVIIHFGFASIVYLKPEASGGDDTVIAVPYTVVTPFLSPLIFSLRNKDMKNAFRKILRNFLNNLVLSLHN", "length": 316, "header": "tr|E1BBC7-1|E1BBC7_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily X member 1 OS=Bos taurus OX=9913 GN=OR10X1 PE=3 SV=4 CANONICAL=E1BBC7-1" }, "locus": { "chromosome": "3", "start_pos": 11126894, "end_pos": 11125947, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052741.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052741.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051838.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051838.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513494", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513494", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BBC7", "url": "https://www.uniprot.org/uniprotkb/E1BBC7" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BBC7", "url": "https://www.uniprot.org/uniprotkb/E1BBC7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBC7", "url": "https://www.uniprot.org/uniprotkb/E1BBC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBC7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBC7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBC7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC7" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 250, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBD0-1", "uniprot_ac": "E1BBD0", "uniprot_id": "E1BBD0_BOVIN", "mass": { "chemical_mass": 54523.0, "monoisotopic_mass": 54523.0 }, "refseq": {}, "gene_names": [ { "name": "KICS2", "type": "recommended", "evidence": [ { "id": "E1BBD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ] } ], "protein_names": [ { "name": "KICSTOR subunit 2", "type": "recommended", "evidence": [ { "id": "E1BBD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0#function" }, { "database": "UniProtKB", "id": "ARBA00054615", "url": "https://www.uniprot.org/uniprotkb/ARBA00054615#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KICS2", "url": "https://www.uniprot.org/uniprotkb/E1BBD0", "locus": { "chromosome": "5", "start_pos": 49512315, "end_pos": 49488643, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013486", "url": "https://www.ensembl.org/id/ENSBTAG00000013486" } ] } } ], "crossref": [ { "id": "E1BBD0", "url": "https://alphafold.ebi.ac.uk/entry/E1BBD0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013486", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013486", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR018544", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018544", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BBD0", "url": "https://www.orthodb.org/?gene=E1BBD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31581", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31581", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31581:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31581:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09404", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09404", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBD0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGTSAPPPGAPGGGRKGSIFPDRQGLGFPVSVTRSRWLNSALPGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGAFGGTAPHVEELLSHLSEQLCFFVQARTEIADFYEKMYTLSTQKFINAEELVGLLDTILKKYSSRFHHPILSPLESSFQLEVDVLSHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKAVQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKALTAKASPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVVIFESKKSERDSHFISFLSEISLALKNPKVFASLKPGSKG", "length": 487, "header": "tr|E1BBD0-1|E1BBD0_BOVIN Isoform 1 of KICSTOR subunit 2 OS=Bos taurus OX=9913 GN=KICS2 PE=3 SV=2 CANONICAL=E1BBD0-1" }, "isoforms": [ { "isoform_ac": "E1BBD0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBD0/entry", "sequence": { "sequence": "MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGTSAPPPGAPGGGRKGSIFPDRQGLGFPVSVTRSRWLNSALPGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGAFGGTAPHVEELLSHLSEQLCFFVQARTEIADFYEKMYTLSTQKFINAEELVGLLDTILKKYSSRFHHPILSPLESSFQLEVDVLSHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKAVQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKALTAKASPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVVIFESKKSERDSHFISFLSEISLALKNPKVFASLKPGSKG", "length": 487, "header": "tr|E1BBD0-1|E1BBD0_BOVIN Isoform 1 of KICSTOR subunit 2 OS=Bos taurus OX=9913 GN=KICS2 PE=3 SV=2 CANONICAL=E1BBD0-1" }, "locus": { "chromosome": "5", "start_pos": 49511311, "end_pos": 49488842, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017932.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017932.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017932.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017932.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "KICSTOR complex", "id": "GO:0140007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140007", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cellular response to glucose starvation", "id": "GO:0042149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "pmid": "" }, { "name": "protein localization to lysosome", "id": "GO:0061462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061462", "evidence": [ { "database": "UniProtKB", "id": "E1BBD0", "url": "https://www.uniprot.org/uniprotkb/E1BBD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBD0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 487, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBD0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBD0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 354, "end_pos": 356 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBG0-1", "uniprot_ac": "E1BBG0", "uniprot_id": "E1BBG0_BOVIN", "mass": { "chemical_mass": 45804.0, "monoisotopic_mass": 45804.0 }, "refseq": { "ac": "XP_002691046", "name": "peroxisomal succinyl-coenzyme A thioesterase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691046" }, "gene_names": [ { "name": "LOC512541", "type": "recommended", "evidence": [ { "id": "E1BBG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" } ] }, { "name": "LOC512541", "type": "synonym", "evidence": [ { "id": "XP_002691046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691046" } ] } ], "protein_names": [ { "name": "Acyl-CoA thioesterase 6", "type": "synonym", "evidence": [ { "id": "E1BBG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG0/entry#names_and_taxonomy" } ] }, { "name": "peroxisomal succinyl-coenzyme A thioesterase", "type": "synonym", "evidence": [ { "id": "XP_002691046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691046" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBG0", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC512541", "url": "https://www.uniprot.org/uniprotkb/E1BBG0", "locus": {} } ], "crossref": [ { "id": "E1BBG0", "url": "https://alphafold.ebi.ac.uk/entry/E1BBG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010270", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010270", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512541", "url": "https://www.ncbi.nlm.nih.gov/gene/512541", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512541", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512541", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VDAWEQI", "url": "https://omabrowser.org/oma/group/VDAWEQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBG0", "url": "https://www.orthodb.org/?gene=E1BBG0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10824", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10824", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10824:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10824:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390247", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390247", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002691046", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691046", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBG0", "url": "https://www.uniprot.org/uniprotkb/E1BBG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBG0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVATVTLEPAGRCRWDEPVRITVRGLAPGQPVTLRASLRDEKGALFRAHARYCADATGLLDLERALALGGSFAGLEPMGLFWALEPEKPFWRFLKRDVQTPFAVELEVLDGHEPETQRLLGRAVHERDFLAPGVRREPVRAGRVRATLFLPPGSGPFPGIIDIYGIGGGLLEYRASLLAGHGFATLAVAYYSFEDLPKKFDTIDLDYFEEALCYMLQHAQIKGPGIGLLGISLGADICLSMASFLKNVSATVTINGSGFNGNKAMYYKENCIPPLGHDLRRVKVAFSGLVDIVDVRNDIVGGCENPCMIPIEKAQGPILFIVGQDDHNWRSEFCAQIASERLQAHGKEKPQIISYPGTGHYIEPPYFPMCPASLHKLLDKPVMWGGEPRAHSKAQVDAWKKILTFFTKHLGLSPKL", "length": 416, "header": "tr|E1BBG0-1|E1BBG0_BOVIN Isoform 1 of Acyl-CoA thioesterase 6 OS=Bos taurus OX=9913 GN=LOC512541 PE=3 SV=1 CANONICAL=E1BBG0-1" }, "isoforms": [ { "isoform_ac": "E1BBG0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG0/entry", "sequence": { "sequence": "MVATVTLEPAGRCRWDEPVRITVRGLAPGQPVTLRASLRDEKGALFRAHARYCADATGLLDLERALALGGSFAGLEPMGLFWALEPEKPFWRFLKRDVQTPFAVELEVLDGHEPETQRLLGRAVHERDFLAPGVRREPVRAGRVRATLFLPPGSGPFPGIIDIYGIGGGLLEYRASLLAGHGFATLAVAYYSFEDLPKKFDTIDLDYFEEALCYMLQHAQIKGPGIGLLGISLGADICLSMASFLKNVSATVTINGSGFNGNKAMYYKENCIPPLGHDLRRVKVAFSGLVDIVDVRNDIVGGCENPCMIPIEKAQGPILFIVGQDDHNWRSEFCAQIASERLQAHGKEKPQIISYPGTGHYIEPPYFPMCPASLHKLLDKPVMWGGEPRAHSKAQVDAWKKILTFFTKHLGLSPKL", "length": 416, "header": "tr|E1BBG0-1|E1BBG0_BOVIN Isoform 1 of Acyl-CoA thioesterase 6 OS=Bos taurus OX=9913 GN=LOC512541 PE=3 SV=1 CANONICAL=E1BBG0-1" }, "locus": { "chromosome": "10", "start_pos": 85045472, "end_pos": 85042309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013568.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013568.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013568.2", "url": "https://www.ensembl.org/id/ENSBTAP00000013568.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512541", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512541", "resource": "KEGG Pathway" }, { "id": "R-BTA-390247", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390247", "resource": "Reactome", "description": "Beta-oxidation of very long chain fatty acids" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8BWN8-1", "protein_name": "Peroxisomal succinyl-coenzyme A thioesterase", "gene_name": "Acot4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATLSVEPTGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGALFRAHARYRADSHGELDLARVPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFLVELEVLDGHEPDGGRRLARTVHERHFMAPGVRRVPVREGRVRATLFLPPGQGPFPGIIDVYGVGGGLLEYRAGLVAGHGFATLALAFYDFEDLPKELNVIEVDYFEEAVRYMLRHPKVKGPDIGLLGLSLGADVCLIMASFLNNVSATVSINGSAFSGNRHIKYKQTMIPPLGHDLRRMKVAFSGILDIVDIRNDAVGGCENPSMIPIEKAKGPILFVAGQDDHCWRSELYTQIASDRLQAHGKERPQVLSYPGTGHYIEPPYFPMCPASLHKIVNEAVIWGGEVKAHSKAQIDAWKQILFFFGKHLGSTHSRASCRL", "length": 421 }, "evidence": [ { "id": "E1BBG0", "url": "https://omabrowser.org/oma/group/E1BBG0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "E1BBG0", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "E1BBG0", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" } ], "pmid": "" }, { "name": "acyl-CoA metabolic process", "id": "GO:0006637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006637", "evidence": [ { "database": "UniProtKB", "id": "E1BBG0", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "fatty acyl-CoA hydrolase activity", "id": "GO:0047617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047617", "evidence": [ { "database": "UniProtKB", "id": "E1BBG0", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" }, { "id": "PF04775", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04775" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 140, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BBG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG0" }, { "id": "PF08840", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08840" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAAT/Acyl-CoA thioester hydrolase C-terminal", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 411, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 247, "end_pos": 249 }, { "start_pos": 255, "end_pos": 257 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBG4-1", "uniprot_ac": "E1BBG4", "uniprot_id": "E1BBG4_BOVIN", "mass": { "chemical_mass": 33559.0, "monoisotopic_mass": 33559.0 }, "refseq": { "ac": "XP_024837251", "name": "RAB7A-interacting MON1-CCZ1 complex subunit 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837251" }, "gene_names": [ { "name": "RIMOC1", "type": "recommended", "evidence": [ { "id": "E1BBG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG4" } ] }, { "name": "RIMOC1", "type": "synonym", "evidence": [ { "id": "XP_024837251", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837251" } ] } ], "protein_names": [ { "name": "RAB7A interacting MON1-CCZ1 complex subunit 1", "type": "synonym", "evidence": [ { "id": "E1BBG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG4/entry#names_and_taxonomy" } ] }, { "name": "RAB7A-interacting MON1-CCZ1 complex subunit 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024837251", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837251" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBG4", "url": "https://www.uniprot.org/uniprotkb/E1BBG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIMOC1", "url": "https://www.uniprot.org/uniprotkb/E1BBG4", "locus": { "chromosome": "20", "start_pos": 32609089, "end_pos": 32634192, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004929", "url": "https://www.ensembl.org/id/ENSBTAG00000004929" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004929", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004929", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "112443003", "url": "https://www.ncbi.nlm.nih.gov/gene/112443003", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112443003", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112443003", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NEGKEHP", "url": "https://omabrowser.org/oma/group/NEGKEHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBG4", "url": "https://www.orthodb.org/?gene=E1BBG4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28494", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28494", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28494:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28494:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024837251", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837251", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBG4", "url": "https://www.uniprot.org/uniprotkb/E1BBG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBG4-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAASSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAALEKLKLQCGEDKECSTPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSQKVKELINFLSEPEILVKENNMHPKHCDLLGDELLECLSWRRGALLYMYCHSLTKRRDWLTRKSSLLKKYLVDGISYLLQMLNFRCPIQLNEGASFQDLDTAKLLSEGIFSDIHLLAMMYSGEMCYWGLKHCADQQPENHEMDIGVSGASYAAHKEPLDFREVGEKILKKYVFVCEGPLKEQEWNTTNAKQILNFFQHHTN", "length": 293, "header": "tr|E1BBG4-1|E1BBG4_BOVIN Isoform 1 of RAB7A interacting MON1-CCZ1 complex subunit 1 OS=Bos taurus OX=9913 GN=RIMOC1 PE=4 SV=1 CANONICAL=E1BBG4-1" }, "isoforms": [ { "isoform_ac": "E1BBG4-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG4/entry", "sequence": { "sequence": "MAAASSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAALEKLKLQCGEDKECSTPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSQKVKELINFLSEPEILVKENNMHPKHCDLLGDELLECLSWRRGALLYMYCHSLTKRRDWLTRKSSLLKKYLVDGISYLLQMLNFRCPIQLNEGASFQDLDTAKLLSEGIFSDIHLLAMMYSGEMCYWGLKHCADQQPENHEMDIGVSGASYAAHKEPLDFREVGEKILKKYVFVCEGPLKEQEWNTTNAKQILNFFQHHTN", "length": 293, "header": "tr|E1BBG4-1|E1BBG4_BOVIN Isoform 1 of RAB7A interacting MON1-CCZ1 complex subunit 1 OS=Bos taurus OX=9913 GN=RIMOC1 PE=4 SV=1 CANONICAL=E1BBG4-1" }, "locus": { "chromosome": "20", "start_pos": 32634172, "end_pos": 32616721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006486.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006486.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006486.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006486.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112443003", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112443003", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JVL5-1", "protein_name": "RAB7A interacting MON1-CCZ1 complex subunit 1", "gene_name": "Rimoc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGFRLVERRRRERGVPLHHTGPSQHRIVGGRGPLGGTQYPERPLRAGAVVARSLCLRPPSGWAPPPFRHPGRQVISCPRGHVDRAGAPELAMAAAVSGVVRRVEELGDLAQAHIQHLSEAAGEDDHFLIRASAALEKLKLLCGEEEECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDCSPQKVKELLAFLSEPEILAKENNMHPKLCDLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSNLLQKYLVDGINYLLQMLNYRCPVQLNEGVSFQDLDTAKLLSTGIFSDIHVLAMMYSGEMCYWGVKHCTDHQSGNHEVDTDVFGTSCTTHREPLDFREVGEKILKKYVSVCEGPLKEQEWNTTNAKQILGFFQQRCS", "length": 386 }, "evidence": [ { "id": "E1BBG4", "url": "https://omabrowser.org/oma/group/E1BBG4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8C2QLW7-1", "protein_name": "UPF0600 protein C5orf51 homolog isoform X1", "gene_name": "C2H5orf51", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAVSGVVRRVEELGDLAQAHIQHLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSPQKVKELLSFLSEPEILVKENNMHPKLCDLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSNLLQKYLVDGINYLLQMLNHRCPIQLNEGVSFQDLDTAKLLSTGIFSDIHVLAMMYSGEMCYWGLKHCTDRQSENHEVNTDVFGASCTTYKEPLDFREVGEKILKKYVSVCEGPLKAQEWNTTNAKQILSFFEQHCS", "length": 294 }, "evidence": [ { "id": "E1BBG4", "url": "https://omabrowser.org/oma/group/E1BBG4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A6NDU8-1", "protein_name": "RAB7A-interacting MON1-CCZ1 complex subunit 1", "gene_name": "RIMOC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSSQKVKELISFLSEPEILVKENNMHPKHCNLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSSLLKKYLLDGISYLLQMLNYRCPIQLNEGVSFQDLDTAKLLSAGIFSDIHLLAMMYSGEMCYWGSKYCADQQPENHEVDTSVSGAGCTTYKEPLDFREVGEKILKKYVSVCEGPLKEQEWNTTNAKQILNFFHHRCN", "length": 294 }, "evidence": [ { "id": "E1BBG4", "url": "https://omabrowser.org/oma/group/E1BBG4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A8Y5U1-1", "protein_name": "RAB7A-interacting MON1-CCZ1 complex subunit 1", "gene_name": "rimoc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADDYRRSVELERRIFELDNKCATLRTEKPDDDYLQNASSILDKLKTYYRHGGESSSLPKLLQDYTQVVLDITFYEENKLVDQEFPEDSSPFKIQQLLQDLTEPEVLAGRLVPAQEVQSVLGLELLECLYWRRGALLYMYCHTLHQRKQWIKKNKATFLKCLQEGVRYLMRMLQVRNSVKLNDGVVFHDSATANFLAEGIFSDTHLLTMMYIGEMCFWAVKYEDCSMDTTERKEDRLHFRDIGTQILHKYVLACEGPLQGQGWNTENAKEILSILQ", "length": 276 }, "evidence": [ { "id": "E1BBG4", "url": "https://omabrowser.org/oma/group/E1BBG4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BR90-1", "protein_name": "RAB7A-interacting MON1-CCZ1 complex subunit 1", "gene_name": "Rimoc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVSGVVRRVEELGDLAQAHIQHLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDCSPQKVKELLAFLSEPEILAKESNMHPKLCGLLGAELLECLSWRRGALLYMYCHSLTKRREWLLRKSNLLQKYLVDGINYLLQMLNYRCPVQLNEGVSFQDLDTAKLLSTGVFSDIHVLAMMYSGEMCYWGLKHCTDQQSENHEVDTDVFGASCTTHKETLDFREVGEKILKKYVSVCEGPLKEQEWNTANAKQILSFFQQRCS", "length": 294 }, "evidence": [ { "id": "E1BBG4", "url": "https://omabrowser.org/oma/group/E1BBG4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BBG4", "url": "https://www.uniprot.org/uniprotkb/E1BBG4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BBG4", "url": "https://www.uniprot.org/uniprotkb/E1BBG4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "E1BBG4", "url": "https://www.uniprot.org/uniprotkb/E1BBG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBG9-1", "uniprot_ac": "E1BBG9", "uniprot_id": "E1BBG9_BOVIN", "mass": { "chemical_mass": 34370.0, "monoisotopic_mass": 34370.0 }, "refseq": { "ac": "NP_001376973", "name": "olfactory receptor family 1 subfamily A member 1C", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376973" }, "gene_names": [ { "name": "OR1A1C", "type": "recommended", "evidence": [ { "id": "E1BBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" } ] }, { "name": "OR1A1C", "type": "synonym", "evidence": [ { "id": "NP_001376973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376973" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 1 subfamily A member 1C", "type": "synonym", "evidence": [ { "id": "E1BBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 1A1", "type": "synonym", "evidence": [ { "id": "NP_001376973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376973" } ] }, { "name": "olfactory receptor family 1 subfamily A member 1C", "type": "synonym", "evidence": [ { "id": "NP_001376973", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376973" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376973" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1A1C", "url": "https://www.uniprot.org/uniprotkb/E1BBG9", "locus": { "chromosome": "19", "start_pos": 23947330, "end_pos": 23948259, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039633", "url": "https://www.ensembl.org/id/ENSBTAG00000039633" } ] } } ], "crossref": [ { "id": "E1BBG9", "url": "https://alphafold.ebi.ac.uk/entry/E1BBG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522582", "url": "https://www.ncbi.nlm.nih.gov/gene/522582", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522582", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522582", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IILAIRC", "url": "https://omabrowser.org/oma/group/IILAIRC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBG9", "url": "https://www.orthodb.org/?gene=E1BBG9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376973", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBG9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREDNQSSTLDFILLGVSGQQEEEDVFFILFLFIYPITLIGNLLIILAIRFDVRLHNPMYFLLASLSFVDIFFSSVTIPKALANHLLGTKAISFGGCLTQMCFMLALGNTDSYILAAMAFDRAVAITRPLHYTTIMSPRTCVLLVIGSWVIGNVNAFPHTLLTASLSFCGNQEVANFYCDIASLLKLSCSDTHFNVKMMYLGAAVFSVPLLCIIISYVRVFSTVLRVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKDAVITVMYIAVTPMLNPFIYSLRNRDMKAALGKLFSRRIFS", "length": 309, "header": "tr|E1BBG9-1|E1BBG9_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily A member 1C OS=Bos taurus OX=9913 GN=OR1A1C PE=3 SV=2 CANONICAL=E1BBG9-1" }, "isoforms": [ { "isoform_ac": "E1BBG9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBG9/entry", "sequence": { "sequence": "MREDNQSSTLDFILLGVSGQQEEEDVFFILFLFIYPITLIGNLLIILAIRFDVRLHNPMYFLLASLSFVDIFFSSVTIPKALANHLLGTKAISFGGCLTQMCFMLALGNTDSYILAAMAFDRAVAITRPLHYTTIMSPRTCVLLVIGSWVIGNVNAFPHTLLTASLSFCGNQEVANFYCDIASLLKLSCSDTHFNVKMMYLGAAVFSVPLLCIIISYVRVFSTVLRVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKDAVITVMYIAVTPMLNPFIYSLRNRDMKAALGKLFSRRIFS", "length": 309, "header": "tr|E1BBG9-1|E1BBG9_BOVIN Isoform 1 of Olfactory receptor family 1 subfamily A member 1C OS=Bos taurus OX=9913 GN=OR1A1C PE=3 SV=2 CANONICAL=E1BBG9-1" }, "locus": { "chromosome": "19", "start_pos": 23948259, "end_pos": 23947333, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057406.3", "url": "https://www.ensembl.org/id/ENSBTAT00000057406.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049522.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049522.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 280, "start_aa": "Thr", "end_pos": 280, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr280", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:522582", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522582", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I9J0-1", "protein_name": "Olfactory receptor 1A1", "gene_name": "LOC100764996", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MREENESSSTDFTLLGVTRQREQEYFFFILFLFIYPITVIGNTLIILAIHSDTRLHNPMYFFLANLSLVDIFFSSVTIPKMLANHLLGSKAISFGGCLAQMYFMIALANTDSYILAAMAYDRAVAISRPLHYATIMSPRPCVLLVVGSWVIGNANALPHTILTASLSFCGNKDVANFYCDITPLLQLSCSDIHFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRAPSTKGFLKALSTCGSHLTVVSLYYGTVMGMYFRPLNSYSLKHALITVMYTAVTPMLNPFIYSLRNRDMKAALRKLFHRSSFSSSM", "length": 312 }, "evidence": [ { "id": "E1BBG9", "url": "https://omabrowser.org/oma/group/E1BBG9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BBG9", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBG9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBG9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBG9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBG9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 280 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBK2-1", "uniprot_ac": "E1BBK2", "uniprot_id": "E1BBK2_BOVIN", "mass": { "chemical_mass": 38263.0, "monoisotopic_mass": 38263.0 }, "refseq": { "ac": "XP_002696146", "name": "allergin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696146" }, "gene_names": [ { "name": "MILR1", "type": "recommended", "evidence": [ { "id": "E1BBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" } ] }, { "name": "MILR1", "type": "synonym", "evidence": [ { "id": "XP_002696146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696146" } ] } ], "protein_names": [ { "name": "Mast cell immunoglobulin like receptor 1", "type": "synonym", "evidence": [ { "id": "E1BBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK2/entry#names_and_taxonomy" } ] }, { "name": "allergin-1", "type": "synonym", "evidence": [ { "id": "XP_002696146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696146" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBK2", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MILR1", "url": "https://www.uniprot.org/uniprotkb/E1BBK2", "locus": { "chromosome": "19", "start_pos": 48641156, "end_pos": 48619177, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007409", "url": "https://www.ensembl.org/id/ENSBTAG00000007409" } ] } } ], "crossref": [ { "id": "E1BBK2", "url": "https://alphafold.ebi.ac.uk/entry/E1BBK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007409", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007409", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "789682", "url": "https://www.ncbi.nlm.nih.gov/gene/789682", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789682", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789682", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR36859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36859:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36859:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17736", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17736", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696146", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696146", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NTK3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTK3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBK2", "url": "https://www.uniprot.org/uniprotkb/E1BBK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBK2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWKKSFLVFLFSLSVQKAALDCERVRKTNELPSPSLHSETDTVRRGQNVSLSCLQQNKSLEITYFLFRGDKRLQTQDGKGEPVTFNLTVSEAHDLGPYKCKVQVANCSKYSLPFNFTFADPVTAPVLNISVIQTKTDRYITLRCISFNGSLPINYIFFEKNITISPVISKDVRKPAEFNITKSNTAEVKEYRCKAKNRLPDHAKYSKPVTIPSTGGDCGPFCLQLLLPGLLLVLIIIILVLAFWMLRKYKARKAMKDSAPRVCRNIPMEAGIYANVCENQADEKPVPGLEPKQCVSSAQDGAKYSQEIHYADPVFQQVAPRDQENSNNSKDGYVYSELVL", "length": 340, "header": "tr|E1BBK2-1|E1BBK2_BOVIN Isoform 1 of Mast cell immunoglobulin like receptor 1 OS=Bos taurus OX=9913 GN=MILR1 PE=4 SV=4 CANONICAL=E1BBK2-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NTK3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTK3/entry", "sequence": { "sequence": "MWKKSFLVFLFSLSVQKAALDCERVRKTNELPSPSLHSETDTVRRGQNVSLSCLQQNKSLEITYFLFRGDKRLQTQDGKGEPVTFNLTVSEAHDLGPYKCKVQVANCSKYSLPFNFTFADPVTAPVLNISVIQTKTDRYITLRCISFNGSLPINYIFFEKNITISPVISKDVRKPAEFNITKSNTAEVKEYRCKAKNRLPDHAKYSKPVTIPSTGGDCGPFCLQLLLPGLLLVLIIIILVLAFWMLRKYKANEKPVPGLEPKQCVSSAQDGAKYSQEIHYADPVFQQVAPRDQENSNNSKDGYVYSELVL", "length": 310, "header": "tr|A0ABI0NTK3-1|A0ABI0NTK3_BOVIN Computationally mapped isoform of Mast cell immunoglobulin like receptor 1 OS=Bos taurus OX=9913 GN=MILR1 PE=4 SV=1 CANONICAL=E1BBK2-1" }, "locus": { "chromosome": "19", "start_pos": 48641125, "end_pos": 48619330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144885.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144885.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106846.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106846.1" } ] } }, { "isoform_ac": "E1BBK2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBK2/entry", "sequence": { "sequence": "MWKKSFLVFLFSLSVQKAALDCERVRKTNELPSPSLHSETDTVRRGQNVSLSCLQQNKSLEITYFLFRGDKRLQTQDGKGEPVTFNLTVSEAHDLGPYKCKVQVANCSKYSLPFNFTFADPVTAPVLNISVIQTKTDRYITLRCISFNGSLPINYIFFEKNITISPVISKDVRKPAEFNITKSNTAEVKEYRCKAKNRLPDHAKYSKPVTIPSTGGDCGPFCLQLLLPGLLLVLIIIILVLAFWMLRKYKARKAMKDSAPRVCRNIPMEAGIYANVCENQADEKPVPGLEPKQCVSSAQDGAKYSQEIHYADPVFQQVAPRDQENSNNSKDGYVYSELVL", "length": 340, "header": "tr|E1BBK2-1|E1BBK2_BOVIN Isoform 1 of Mast cell immunoglobulin like receptor 1 OS=Bos taurus OX=9913 GN=MILR1 PE=4 SV=4 CANONICAL=E1BBK2-1" }, "locus": { "chromosome": "19", "start_pos": 48641125, "end_pos": 48619330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042694.6", "url": "https://www.ensembl.org/id/ENSBTAT00000042694.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040326.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040326.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789682", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789682", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "E1BBK2", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "E1BBK2", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1BBK2", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BBK2", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBK2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 340, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBK2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBK2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 111, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 115, "end_pos": 117 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBK3-1", "uniprot_ac": "E1BBK3", "uniprot_id": "E1BBK3_BOVIN", "mass": { "chemical_mass": 14950.0, "monoisotopic_mass": 14950.0 }, "refseq": { "ac": "XP_059737504", "name": "FLYWCH family member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737504" }, "gene_names": [ { "name": "FLYWCH2", "type": "recommended", "evidence": [ { "id": "E1BBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK3" } ] }, { "name": "FLYWCH2", "type": "synonym", "evidence": [ { "id": "XP_059737504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737504" } ] } ], "protein_names": [ { "name": "FLYWCH family member 2", "type": "synonym", "evidence": [ { "id": "XP_059737504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737504" }, { "id": "E1BBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBK3", "url": "https://www.uniprot.org/uniprotkb/E1BBK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FLYWCH2", "url": "https://www.uniprot.org/uniprotkb/E1BBK3", "locus": { "chromosome": "25", "start_pos": 2327785, "end_pos": 2321564, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038115", "url": "https://www.ensembl.org/id/ENSBTAG00000038115" } ] } } ], "crossref": [ { "id": "E1BBK3", "url": "https://alphafold.ebi.ac.uk/entry/E1BBK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038115", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038115", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100847890", "url": "https://www.ncbi.nlm.nih.gov/gene/100847890", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040312", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040312", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847890", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847890", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTVCPSM", "url": "https://omabrowser.org/oma/group/PTVCPSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBK3", "url": "https://www.orthodb.org/?gene=E1BBK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31665", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31665", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31665:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31665:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059737504", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737504", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBK3", "url": "https://www.uniprot.org/uniprotkb/E1BBK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBK3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLPEPSEQEGESVKAGQEPSPEPPQPGTDVVPAAPKKPRKFSKLVLLTASKDSAKVEGAKRKGVHCIMSLGVPGPATLAKALLKIHPEAQRAIEAAPQEPEQKRSKLDTDGEEDGSLAGPSAPSPLVDGEESTSALVKPRAAP", "length": 144, "header": "tr|E1BBK3-1|E1BBK3_BOVIN Isoform 1 of FLYWCH family member 2 OS=Bos taurus OX=9913 GN=FLYWCH2 PE=4 SV=1 CANONICAL=E1BBK3-1" }, "isoforms": [ { "isoform_ac": "E1BBK3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBK3/entry", "sequence": { "sequence": "MPLPEPSEQEGESVKAGQEPSPEPPQPGTDVVPAAPKKPRKFSKLVLLTASKDSAKVEGAKRKGVHCIMSLGVPGPATLAKALLKIHPEAQRAIEAAPQEPEQKRSKLDTDGEEDGSLAGPSAPSPLVDGEESTSALVKPRAAP", "length": 144, "header": "tr|E1BBK3-1|E1BBK3_BOVIN Isoform 1 of FLYWCH family member 2 OS=Bos taurus OX=9913 GN=FLYWCH2 PE=4 SV=1 CANONICAL=E1BBK3-1" }, "locus": { "chromosome": "25", "start_pos": 2327752, "end_pos": 2326120, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055417.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055417.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049567.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049567.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100847890", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847890", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6APL1-1", "protein_name": "FLYWCH family member 2", "gene_name": "Flywch2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLPQSSEQEGESMKATQEPAPQPGTDVVPAAPRKPRKFSKLVLLTASKDSAKVAGAKRKGVHCIMSLGVPGPATLAKALLKTHPEAQRAIEATPPEPEQKRSKPNLGGPEDNGGSGGSSSSPVETTALPKAPSASP", "length": 137 }, "evidence": [ { "id": "E1BBK3", "url": "https://omabrowser.org/oma/group/E1BBK3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LNJ8-1", "protein_name": "FLYWCH family member 2", "gene_name": "FLYWCH2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPLPEPSEQEGESVKAGQEPCPKSPEPGTDVVPAAPMKPRKFSKLVLLTASKDSAKVAGAKRKGVHCIMSLGVPGPATLAKALLKTHPEAQRAIEATPQEPEQKRSKVDTDGKEDGSMAGEPVPSSSSGGREESAVGPLIVPAMPGEAP", "length": 149 }, "evidence": [ { "id": "E1BBK3", "url": "https://omabrowser.org/oma/group/E1BBK3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96CP2-1", "protein_name": "FLYWCH family member 2", "gene_name": "FLYWCH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLPEPSEQEGESVKASQEPSPKPGTEVIPAAPRKPRKFSKLVLLTASKDSTKVAGAKRKGVHCVMSLGVPGPATLAKALLQTHPEAQRAIEAAPQEPEQKRSRQDPGTDRTEDSGLAAGPPEAAGENFAPCSVAPGKSL", "length": 140 }, "evidence": [ { "id": "E1BBK3", "url": "https://omabrowser.org/oma/group/E1BBK3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQE9-1", "protein_name": "FLYWCH family member 2", "gene_name": "Flywch2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQPKPSEQEGESMKASQEPAPQPGTDVVPAAPRKPRKFSKLVLLTASKDSAKVAGAKRKGVHCIMSLGVPGPATLAKALLKTHPEAQRAIEATPLEPEQKRSKQNLDSDGPEDNGGSGVSSSSSEETTVLPEAPSTSP", "length": 139 }, "evidence": [ { "id": "E1BBK3", "url": "https://omabrowser.org/oma/group/E1BBK3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBK3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBK3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBK3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBL1-1", "uniprot_ac": "E1BBL1", "uniprot_id": "E1BBL1_BOVIN", "mass": { "chemical_mass": 51031.0, "monoisotopic_mass": 51031.0 }, "refseq": { "ac": "XP_005226216", "name": "SH2 domain-containing protein 4A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226216" }, "gene_names": [ { "name": "SH2D4A", "type": "recommended", "evidence": [ { "id": "E1BBL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" } ] }, { "name": "SH2D4A", "type": "synonym", "evidence": [ { "id": "XP_005226216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226216" } ] } ], "protein_names": [ { "name": "SH2 domain containing 4A", "type": "synonym", "evidence": [ { "id": "E1BBL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBL1/entry#names_and_taxonomy" } ] }, { "name": "SH2 domain-containing protein 4A", "type": "synonym", "evidence": [ { "id": "XP_005226216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226216" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBL1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH2D4A", "url": "https://www.uniprot.org/uniprotkb/E1BBL1", "locus": { "chromosome": "27", "start_pos": 38245298, "end_pos": 38307774, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001186", "url": "https://www.ensembl.org/id/ENSBTAG00000001186" } ] } } ], "crossref": [ { "id": "E1BBL1", "url": "https://alphafold.ebi.ac.uk/entry/E1BBL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001186", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001186", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506242", "url": "https://www.ncbi.nlm.nih.gov/gene/506242", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506242", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506242", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NRMKTYG", "url": "https://omabrowser.org/oma/group/NRMKTYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBL1", "url": "https://www.orthodb.org/?gene=E1BBL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14388:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14388:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005226216", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226216", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBL1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBL1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKQILSEMYIDPDLLAELNEEQKQILFFKMREEQVRRWKEREASMEKQESLPVKPRPKKDNGRSVHWKLGADNEVWVWVMGEHHLDKPYDVICDEILAERARLKAEQETPELRKAQPGELSSSSKSKLPSSEGRAPGAGETGNVGDKVAEAGTPGRGCGPAAPLAEQKAPLSSSSSRNIHQMLADSVSRIKEFGFHQKKVSVKKTQDEEIKQIDEERTKEIYKNWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGKGQQGPPGGPQKPKRPPLPPKPHFLSPAGQPHTPLRNQRVRRPASSPAQEDIRRWFQEEQLPLRAGYLADSDSIAPWFHGILTVNRANELLSTCVPGSFLIRVNEKVKGYTLSYQSEDGCKHFLIDASSDSYSFLGVDQLQHASLAELVEYHKEEPITSLGKELLLYPCGQQREPPDYLELFE", "length": 450, "header": "tr|E1BBL1-1|E1BBL1_BOVIN Isoform 1 of SH2 domain containing 4A OS=Bos taurus OX=9913 GN=SH2D4A PE=4 SV=1 CANONICAL=E1BBL1-1" }, "isoforms": [ { "isoform_ac": "E1BBL1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1/entry", "sequence": { "sequence": "MLKQILSEMYIDPDLLAELNEEQKQILFFKMREEQVRRWKEREASMEKQESLPVKPRPKKDNGRSVHWKLGADNEVWVWVMGEHHLDKPYDVICDEILAERARLKAEQETPELRKAQPGELSSSSKSKLPSSEGRAPGAGETGNVGDKVAEAGTPGRGCGPAAPLAEQKAPLSSSSSRNIHQMLADSVSRIKEFGFHQKKVSVKKTQDEEIKQIDEERTKEIYKNWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGKGQQGPPGGPQKPKRPPLPPKPHFLSPAGQPHTPLRNQRVRRPASSPAQEDIRRWFQEEQLPLRAGYLADSDSIAPWFHGILTVNRANELLSTCVPGSFLIRVNEKVKGYTLSYQSEDGCKHFLIDASSDSYSFLGVDQLQHASLAELVEYHKEEPITSLGKELLLYPCGQQREPPDYLELFE", "length": 450, "header": "tr|E1BBL1-1|E1BBL1_BOVIN Isoform 1 of SH2 domain containing 4A OS=Bos taurus OX=9913 GN=SH2D4A PE=4 SV=1 CANONICAL=E1BBL1-1" }, "locus": { "chromosome": "27", "start_pos": 38301674, "end_pos": 38246302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001572.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001572.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001572.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001572.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 154, "start_aa": "Thr", "end_pos": 154, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr154", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506242", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506242", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C428-1", "protein_name": "SH2 domain containing 4A", "gene_name": "SH2D4A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLKQILSEMYIDPDLLAELSEEQKQILFFKMRQEQIRRWKEREAAADKVSAKKPLPKKASTKSVQWKLGADNDVWVWVMGEHPSDKSYAAICEEIQAQRAKRLASEQGKETRETDCAVTQSLQPQPEVLGETEVQGKNKNTVEEQKEEARKNTAGTIGKSQELKKREARDVHQMLADCQMRKGGFSQMKGGHGRNSGEETTVPLKAIPQSHTCSESQKMLQKSDENEPEWQESLRKSKAADEKRRSLARQARDDYRRLSLQGAHRGKQADISKNATAGDRRPLQYPPLPPKPKLLPPAMANGRAVRKEGIQRTISNSAEESIIRWFKEEQFPLRAGYQKTTDTIAPWFHGILTSRKAEELLSKTVPGSFLVRVSEKIKGYVLSYRSAEGCKHFLIDASSDSYSFLGVDQLQHSTLADLVDYHKDEPITSMGKELLLYPCGQEDHEPDYTCLFE", "length": 453 }, "evidence": [ { "id": "E1BBL1", "url": "https://omabrowser.org/oma/group/E1BBL1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H6V3-1", "protein_name": "SH2 domain-containing protein 4A", "gene_name": "Sh2d4a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDLLCDEILAEREHLRTVQDSTLRKAQAAKSTNSQALAKLEPQNVTQKAAAEEASGQGPRATPTKNEDKAHTKEPIKKKEDEDVKQTEDEKTKQIYKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLAGPQKPRRPPLPPKPLFLHPLGNPPKSLGNQGVIRTESSSTQEDIIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANDLLSTGVPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASADSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDKLPDYLELFE", "length": 412 }, "evidence": [ { "id": "E1BBL1", "url": "https://omabrowser.org/oma/group/E1BBL1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6AYC8-1", "protein_name": "SH2 domain-containing protein 4A", "gene_name": "Sh2d4a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRQILSEMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDAELRKAQSLQFTNSLKVKSLNCDLQAVKKTEPQNVTRKAAAEEATDQGPRAIPTKKDDKAQTKDLTKKKDSEELKQTEDEKTKQIYKNWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPKRPPLPPKPQFLQPLGSPPKSLGNQGVIRTKTSSTQEDIIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGMPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLFPCGQQDKPPDYLELFQ", "length": 422 }, "evidence": [ { "id": "E1BBL1", "url": "https://omabrowser.org/oma/group/E1BBL1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D7V1-1", "protein_name": "SH2 domain-containing protein 4A", "gene_name": "Sh2d4a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGKSVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDSELRKTQSLELANSLKIKSQNCDLQAMKKTEPQNVTRKAASEEASGQGPRAIPTRKDDKAQTKPVKEKDHEEMKQTEDEKTKQIYKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPLPPKPQFLQPLGIPPKSLGNQGVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKANELLSTGVPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDKLPDYLELFQ", "length": 421 }, "evidence": [ { "id": "E1BBL1", "url": "https://omabrowser.org/oma/group/E1BBL1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H788-1", "protein_name": "SH2 domain-containing protein 4A", "gene_name": "SH2D4A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLYPCGQQDQLPDYLELFE", "length": 454 }, "evidence": [ { "id": "E1BBL1", "url": "https://omabrowser.org/oma/group/E1BBL1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBL1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BBL1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "E1BBL1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" } ], "pmid": "" }, { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "E1BBL1", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBL1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 450, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBL1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBL1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBL1" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 344, "end_pos": 436, "start_aa": "Trp", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 154 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BBM0-1", "uniprot_ac": "E1BBM0", "uniprot_id": "E1BBM0_BOVIN", "mass": { "chemical_mass": 45807.0, "monoisotopic_mass": 45807.0 }, "refseq": { "ac": "XP_002695756", "name": "rRNA methyltransferase 3, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695756" }, "gene_names": [ { "name": "MRM3", "type": "recommended", "evidence": [ { "id": "E1BBM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ] }, { "name": "MRM3", "type": "synonym", "evidence": [ { "id": "XP_002695756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695756" } ] } ], "protein_names": [ { "name": "Mitochondrial rRNA methyltransferase 3", "type": "synonym", "evidence": [ { "id": "E1BBM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM0/entry#names_and_taxonomy" } ] }, { "name": "rRNA methyltransferase 3, mitochondrial", "type": "synonym", "evidence": [ { "id": "XP_002695756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695756" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM0", "locus": { "chromosome": "19", "start_pos": 22059688, "end_pos": 22065200, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019162", "url": "https://www.ensembl.org/id/ENSBTAG00000019162" } ] } } ], "crossref": [ { "id": "E1BBM0", "url": "https://alphafold.ebi.ac.uk/entry/E1BBM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019162", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019162", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18106", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18106", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538817", "url": "https://www.ncbi.nlm.nih.gov/gene/538817", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538817", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538817", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FLKFHKY", "url": "https://omabrowser.org/oma/group/FLKFHKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBM0", "url": "https://www.orthodb.org/?gene=E1BBM0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43191", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43191", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43191:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43191:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00588", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00588", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695756", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695756", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBM0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALVKRVGLGTRPLLPVVQAWDLDARRWVRALRRSPVKVLFPSGEVVERKLDPGKQPRKAAAEASPREQRQKQQIQGPASQTPSTWEESGLRYDKAFPGDKRLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPQIFFFSRLEYIKELPIEKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDHVKMTYPETQLRHTLPISLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIINNLDWEAVPDHLPTDTRVYVADNCGLYVQAQAQRSNKASDYGWVRDQRPLKFHEYEEEDLESGASQCWLPELEVQSYDSDWTEAPAAVVIGGETHGVSLESLQLAESTGGGRLLIPVVPGVDSLNSAMAASILLFEGKRQLRVRDGC", "length": 413, "header": "tr|E1BBM0-1|E1BBM0_BOVIN Isoform 1 of Mitochondrial rRNA methyltransferase 3 OS=Bos taurus OX=9913 GN=MRM3 PE=3 SV=3 CANONICAL=E1BBM0-1" }, "isoforms": [ { "isoform_ac": "E1BBM0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM0/entry", "sequence": { "sequence": "MAALVKRVGLGTRPLLPVVQAWDLDARRWVRALRRSPVKVLFPSGEVVERKLDPGKQPRKAAAEASPREQRQKQQIQGPASQTPSTWEESGLRYDKAFPGDKRLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPQIFFFSRLEYIKELPIEKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDHVKMTYPETQLRHTLPISLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIINNLDWEAVPDHLPTDTRVYVADNCGLYVQAQAQRSNKASDYGWVRDQRPLKFHEYEEEDLESGASQCWLPELEVQSYDSDWTEAPAAVVIGGETHGVSLESLQLAESTGGGRLLIPVVPGVDSLNSAMAASILLFEGKRQLRVRDGC", "length": 413, "header": "tr|E1BBM0-1|E1BBM0_BOVIN Isoform 1 of Mitochondrial rRNA methyltransferase 3 OS=Bos taurus OX=9913 GN=MRM3 PE=3 SV=3 CANONICAL=E1BBM0-1" }, "locus": { "chromosome": "19", "start_pos": 22065001, "end_pos": 22060692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025502.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025502.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025502.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025502.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538817", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538817", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AKP0-1", "protein_name": "Mitochondrial rRNA methyltransferase 3", "gene_name": "MRM3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALRRAVPVLSRALAGPGGAAPGRRWVRALRRSPVRVLPPRKEQAEAQKRPVEHHPPPPAVERGSAGPGLWYEKASPGDRSLGKVVTIAKSRSFRDRHGKVLLEGLRLIRDALQAGAAPRALFFSTAEHLRELPPAPLKGARLVRVRFEDIKCWSDVVAPQGMIGIFSKPDHAKMSYPTAQLPIVLICDNIRDPGNLGTILRSAAGAGCEKVLLTKGCVDPWEPKVLRAGMGAHFRVPIVADLDWESVPSNLPSGVQVCVADNKDLGAQAETEPTSQGAGRSGSHSGNPKAPVKPKRKAAPPEHKDEEGTEGVCASELAAQYYYENWIQSPAAVVVGGETHGLSPDALHLAASTGGKRLVIPVVPGVDSLNSAVAAAIVLFEGKRQLQWRTHKQDNEKQFIPSIVG", "length": 407 }, "evidence": [ { "id": "E1BBM0", "url": "https://omabrowser.org/oma/group/E1BBM0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZQG0-1", "protein_name": "Mitochondrial rRNA methyltransferase 3", "gene_name": "Mrm3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPAKGMWYSLGPLLRVVQTRDLDARRWVRALRRSPVRVLFPSGQVEERKRAPDKQPRKAVPEASSQGQQQKQPLETSPSQTPHTWEEAGLRYDKACPGDRRLSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPKMFFFSRLEYIKELPVDKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDPVKMTYPETQLHHSLPLLLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIVNNVEWETVPNHLPPDTRVYVADNCGLYAQVQMSNKTGDRDWACDRRFLKFHKNEVDLDTKARKDWLPKLEVQSYDLDWTEAPAALVIGGETHGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRIKMGDLSRDSCCH", "length": 417 }, "evidence": [ { "id": "E1BBM0", "url": "https://omabrowser.org/oma/group/E1BBM0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RHK0-1", "protein_name": "Mitochondrial rRNA methyltransferase 3", "gene_name": "MRM3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALVQRVGWATRTLLLVTRARDLGARRGVRALRRSPVKVLFPSGQAVERKPGPGKQPRKAAAEASSREQRLNQPLQVPASQTPSTWEESGLRYDKAFPGDKRLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPKIFFFSRLEYIKELPIEKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDHAKMTYPETQLRHTLPLLLICDNLRDPGNLGTILRSAAGAGCSRVLLTKGCVDAWEPKVLRAGMGAHFQVPIINNLDWETVPKYLPTDTRVYVADNCGLYAQAQARASTKASDYGWVCDRRAKLHQYEEEGEDVESGASKGWLPELQVQTYDADWTEAPAAVVIGGETHGVSLESLQLAESTGGGRLLIPVVPGVDSLNSAMAASILLFEGKRQLRVRAEHLSRDRGCH", "length": 422 }, "evidence": [ { "id": "E1BBM0", "url": "https://omabrowser.org/oma/group/E1BBM0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HTH0-1", "protein_name": "rRNA methyltransferase 3, mitochondrial", "gene_name": "Mrm3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAPARALSSSLIPLLRVIQTRDLGARRWVRALRRSPVRVVFPSGQVEERKRAPVQQPRKAVPEASSQQQRHKHALETSPSQTPHTWEETGLRYDKAFPGDRRLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPKVFFFSRLEYIKELPVDKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDPVKMTYPETQLHHSLPLVLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIVNNLEWETVPNHLPPDTRVYVADNCGLYAQAQISNKTSDHDWACDRRFLKFHKYEEEDLDSKTRKDWLPKLEVQSYDLDWTEAPAAVVIGGETHGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRIKVEDLSSERSYH", "length": 419 }, "evidence": [ { "id": "E1BBM0", "url": "https://omabrowser.org/oma/group/E1BBM0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ND52-1", "protein_name": "rRNA methyltransferase 3, mitochondrial", "gene_name": "Mrm3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPAKGMWCSLGSLLRVVQTRDLNARRWVRALRRSPVRVLSPSGQVEERKRAPDQQPRKAVPKASSQGQRQKQPLETSPSQTPHTWEEAGLRYDKAFPGDRRLSSVMTIVKSRPFREKQGKILLEGRRLIADALKAGAVPKAFFFSRLEYVKELPVDKLKDVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDPVKMTYPETPLHHTLPLVLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFQVPIVNNVEWETVPNHLPPDTRVYVADNCGHYAQVQMSDKTGDRDWACDRRFLKFHKYEEDLDTKTRKDWLPKLEVQSYDLDWTGAPAAVVIGGETHGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRIKVEDLSRDRSYH", "length": 418 }, "evidence": [ { "id": "E1BBM0", "url": "https://omabrowser.org/oma/group/E1BBM0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HC36-1", "protein_name": "rRNA methyltransferase 3, mitochondrial", "gene_name": "MRM3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALVRPARFVVRPLLQVVQAWDLDARRWVRALRRSPVKVVFPSGEVVEQKRAPGKQPRKAPSEASAQEQREKQPLEESASRAPSTWEESGLRYDKAYPGDRRLSSVMTIVKSRPFREKQGKILLEGRRLISDALKAGAVPKMFFFSRLEYLKELPVDKLKGVSLIKVKFEDIKDWSDLVTPQGIMGIFAKPDHVKMTYPKTQLQHSLPLLLICDNLRDPGNLGTILRSAAGAGCSKVLLTKGCVDAWEPKVLRAGMGAHFRMPIINNLEWETVPNYLPPDTRVYVADNCGLYAQAEMSNKASDHGWVCDQRVMKFHKYEEEEDVETGASQDWLPHVEVQSYDSDWTEAPAAVVIGGETYGVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRGRAEDLSRDRSYH", "length": 420 }, "evidence": [ { "id": "E1BBM0", "url": "https://omabrowser.org/oma/group/E1BBM0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ], "pmid": "" }, { "name": "RNA methyltransferase activity", "id": "GO:0008173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008173", "evidence": [ { "database": "UniProtKB", "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "E1BBM0", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBM0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 413, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBM0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBM0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM0" }, { "id": "SM00967", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00967" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RNA 2-O ribose methyltransferase substrate binding", "eco_id": "ECO_0000259", "start_pos": 124, "end_pos": 195, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC62-1", "uniprot_ac": "E1BC62", "uniprot_id": "E1BC62_BOVIN", "mass": { "chemical_mass": 17783.0, "monoisotopic_mass": 17783.0 }, "refseq": { "ac": "NP_001193187", "name": "sperm microtubule associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193187" }, "gene_names": [ { "name": "SPMAP1", "type": "recommended", "evidence": [ { "id": "E1BC62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC62" } ] }, { "name": "C19H17orf98", "type": "synonym", "evidence": [ { "id": "NP_001193187", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193187" }, { "id": "E1BC62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC62" } ] } ], "protein_names": [ { "name": "Sperm microtubule associated protein 1", "type": "synonym", "evidence": [ { "id": "E1BC62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC62/entry#names_and_taxonomy" } ] }, { "name": "sperm microtubule associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001193187", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193187" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC62", "url": "https://www.uniprot.org/uniprotkb/E1BC62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPMAP1", "url": "https://www.uniprot.org/uniprotkb/E1BC62", "locus": { "chromosome": "19", "start_pos": 39431975, "end_pos": 39435348, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044056", "url": "https://www.ensembl.org/id/ENSBTAG00000044056" } ] } } ], "crossref": [ { "id": "E1BC62", "url": "https://alphafold.ebi.ac.uk/entry/E1BC62", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044056", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044056", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616773", "url": "https://www.ncbi.nlm.nih.gov/gene/616773", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR028027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616773", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616773", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QKEFILD", "url": "https://omabrowser.org/oma/group/QKEFILD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC62", "url": "https://www.orthodb.org/?gene=E1BC62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34221:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34221:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF15075", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15075", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193187", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BC62", "url": "https://www.uniprot.org/uniprotkb/E1BC62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC62-1", "url": "https://www.uniprot.org/uniprotkb/E1BC62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHLCACPLRREKGFILDGVAVSTMARSYEHLRPKLWSAIPPYNAQQDCHSRRYFRSRVVPPILRETDQDHGGTGRDGWIVDYFHIFGQGQRYLNRRNWAGAGHSLQQVTGHDHYNTNLKAIQGFNGRFGYRRNTPALRHCPSVFGEITRFPLF", "length": 154, "header": "tr|E1BC62-1|E1BC62_BOVIN Isoform 1 of Sperm microtubule associated protein 1 OS=Bos taurus OX=9913 GN=SPMAP1 PE=1 SV=1 CANONICAL=E1BC62-1" }, "isoforms": [ { "isoform_ac": "E1BC62-1", "url": "https://www.uniprot.org/uniprotkb/E1BC62/entry", "sequence": { "sequence": "MAHLCACPLRREKGFILDGVAVSTMARSYEHLRPKLWSAIPPYNAQQDCHSRRYFRSRVVPPILRETDQDHGGTGRDGWIVDYFHIFGQGQRYLNRRNWAGAGHSLQQVTGHDHYNTNLKAIQGFNGRFGYRRNTPALRHCPSVFGEITRFPLF", "length": 154, "header": "tr|E1BC62-1|E1BC62_BOVIN Isoform 1 of Sperm microtubule associated protein 1 OS=Bos taurus OX=9913 GN=SPMAP1 PE=1 SV=1 CANONICAL=E1BC62-1" }, "locus": { "chromosome": "19", "start_pos": 39435348, "end_pos": 39432069, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061352.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061352.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053755.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "E1BC62", "url": "https://www.uniprot.org/uniprotkb/E1BC62" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] }, { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1BC62", "url": "https://www.uniprot.org/uniprotkb/E1BC62" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:616773", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616773", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A260-1", "protein_name": "Sperm microtubule associated protein 1", "gene_name": "SPMAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARLCQCPLRLEKSFILDGVAVSTTARSYERLRPKLWSAIPPYNAQQDYHAHRYFRSHVVPPILRKTEQDHGGTGRDGWIVDYFHVFGQGQRYLNRRNWAGAGHSLQQVTGHDHYNTNLKATQGFNGRFGYRRNTPALRQRPSVFGEVTQFPLF", "length": 154 }, "evidence": [ { "id": "E1BC62", "url": "https://omabrowser.org/oma/group/E1BC62/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A8MV24-1", "protein_name": "Sperm microtubule associated protein 1", "gene_name": "SPMAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAYLSECRLRLEKGFILDGVAVSTAARAYGRSRPKLWSAIPPYNAQQDYHARSYFQSHVVPPLLRKTDQDHGGTGRDGWIVDYIHIFGQGQRYLNRRNWAGTGHSLQQVTGHDHYNADLKPIDGFNGRFGYRRNTPALRQSTSVFGEVTHFPLF", "length": 154 }, "evidence": [ { "id": "E1BC62", "url": "https://omabrowser.org/oma/group/E1BC62/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1LW61-1", "protein_name": "Sperm microtubule associated protein 1", "gene_name": "Spmap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRCYYDSPLRLEKAFVLDGVAVSSMAHAYSILRPKLWSAIPPYNPQLDHHAHRYFRSHVVPPVLRKTDQDHGGTGRDGWIVDYFHIFGQGQRYLNRRNWAGAGHSLQQVSGHDYYNANPKVITAGLNGRFGYRRNTPALRQRTSVFGEVTPFPIF", "length": 156 }, "evidence": [ { "id": "E1BC62", "url": "https://omabrowser.org/oma/group/E1BC62/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DAQ5-1", "protein_name": "Sperm microtubule associated protein 1", "gene_name": "Spmap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACCYNSPRRLEKSFVLDGVAVSTMAQAYSIMRPKLWSAIPPYNPQLDHHSRRYFRSRVVPPILRKTDQDHGGTGRDGWIVDYFHIFGQGQRYLNRRNWAGAGHSLQQVSGHDYYNSNPKAITTGLNGRFGYRRNTPALRQHTSVFGEVTPFPIF", "length": 155 }, "evidence": [ { "id": "E1BC62", "url": "https://omabrowser.org/oma/group/E1BC62/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC62-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC62-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC62" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC72-1", "uniprot_ac": "E1BC72", "uniprot_id": "E1BC72_BOVIN", "mass": { "chemical_mass": 48702.0, "monoisotopic_mass": 48702.0 }, "refseq": { "ac": "NP_001192768", "name": "transcription factor Sp9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192768" }, "gene_names": [ { "name": "SP9", "type": "recommended", "evidence": [ { "id": "E1BC72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ] }, { "name": "SP9", "type": "synonym", "evidence": [ { "id": "NP_001192768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192768" } ] } ], "protein_names": [ { "name": "Sp9 transcription factor homolog", "type": "synonym", "evidence": [ { "id": "NP_001192768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192768" } ] }, { "name": "Sp9 transcription factor", "type": "synonym", "evidence": [ { "id": "E1BC72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC72/entry#names_and_taxonomy" } ] }, { "name": "transcription factor Sp9", "type": "synonym", "evidence": [ { "id": "NP_001192768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192768" } ] } ], "function": [ { "annotation": "Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72#function" }, { "database": "UniProtKB", "id": "ARBA00037677", "url": "https://www.uniprot.org/uniprotkb/ARBA00037677#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SP9", "url": "https://www.uniprot.org/uniprotkb/E1BC72", "locus": { "chromosome": "2", "start_pos": 22449123, "end_pos": 22451576, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014949", "url": "https://www.ensembl.org/id/ENSBTAG00000014949" } ] } } ], "crossref": [ { "id": "E1BC72", "url": "https://alphafold.ebi.ac.uk/entry/E1BC72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014949", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014949", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22549", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22549", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517257", "url": "https://www.ncbi.nlm.nih.gov/gene/517257", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517257", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517257", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVCESVG", "url": "https://omabrowser.org/oma/group/WVCESVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC72", "url": "https://www.orthodb.org/?gene=E1BC72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192768", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC72-1", "url": "https://www.uniprot.org/uniprotkb/E1BC72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGGRGSGGLAGGSGAANSAFCLASTSPTSSAFSSDYGGLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPSYSDSSAAVAAAAASAMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAASAGGKEAASGPNDS", "length": 481, "header": "tr|E1BC72-1|E1BC72_BOVIN Isoform 1 of Sp9 transcription factor OS=Bos taurus OX=9913 GN=SP9 PE=3 SV=1 CANONICAL=E1BC72-1" }, "isoforms": [ { "isoform_ac": "E1BC72-1", "url": "https://www.uniprot.org/uniprotkb/E1BC72/entry", "sequence": { "sequence": "MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGGRGSGGLAGGSGAANSAFCLASTSPTSSAFSSDYGGLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPSYSDSSAAVAAAAASAMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAASAGGKEAASGPNDS", "length": 481, "header": "tr|E1BC72-1|E1BC72_BOVIN Isoform 1 of Sp9 transcription factor OS=Bos taurus OX=9913 GN=SP9 PE=3 SV=1 CANONICAL=E1BC72-1" }, "locus": { "chromosome": "2", "start_pos": 22451576, "end_pos": 22449126, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019897.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019897.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019897.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019897.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517257", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517257", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZTZ1-1", "protein_name": "Sp9 transcription factor", "gene_name": "SP9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGGRGSGALAGGSGAANSAFCLASTSPTSSAFSSDYGGLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPSYSDSSAAVAAAAASAMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAAAAAASAGGKEAASGPNDS", "length": 485 }, "evidence": [ { "id": "E1BC72", "url": "https://omabrowser.org/oma/group/E1BC72/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZZ24-1", "protein_name": "Sp9 transcription factor", "gene_name": "Sp9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGGRGSGSLAGGSGAANSAFCLASTSPTSSAFSSDYGGLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPSYSDSSAAVAAAAASAMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAAAAAASAGGKEAATGPNDS", "length": 485 }, "evidence": [ { "id": "E1BC72", "url": "https://omabrowser.org/oma/group/E1BC72/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0CG40-1", "protein_name": "Transcription factor Sp9", "gene_name": "SP9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGGRGSGGLAGGSGAANSAFCLASTSPTSSAFSSDYGGLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPSYSDSSAAVAAAAASAMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAAAAASAGGKEAASGPNDS", "length": 484 }, "evidence": [ { "id": "E1BC72", "url": "https://omabrowser.org/oma/group/E1BC72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64HY3-1", "protein_name": "Transcription factor Sp9", "gene_name": "Sp9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATGGRGSGSLAGGSGAANSAFCLASTSPTSSAFSSDYGGLFSNSAAAAAAAAGVSPQEAGGQSAFISKVHTTAADGLYPRVGMAHPYESWYKSGFHSTLAAGEVTNGAASSWWDVHSSPGSWLEVQNPAGGLQSSLHSGAPQASLHSQLGTYNPDFSSLTHSAFSSTGLGSSAAAASHLLSTSQHLLAQDGFKPVLPSYSDSSAAVAAAAASAMISGAAAAAAGGSSARSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLILHDSGVSAARAAAAAAAAAAAAAAAASAGGKEAATGPNDS", "length": 484 }, "evidence": [ { "id": "E1BC72", "url": "https://omabrowser.org/oma/group/E1BC72/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" }, { "name": "embryonic limb morphogenesis", "id": "GO:0030326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030326", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BC72", "url": "https://www.uniprot.org/uniprotkb/E1BC72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC72-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 481, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC72-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC72" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC72" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 332, "end_pos": 361, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 29, "end_pos": 31 }, { "start_pos": 479, "end_pos": 481 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BC94-1", "uniprot_ac": "E1BC94", "uniprot_id": "E1BC94_BOVIN", "mass": { "chemical_mass": 38231.0, "monoisotopic_mass": 38231.0 }, "refseq": { "ac": "NP_001192509", "name": "iron-sulfur cluster assembly factor IBA57, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509" }, "gene_names": [ { "name": "IBA57", "type": "recommended", "evidence": [ { "id": "E1BC94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC94" } ] }, { "name": "C7H1orf69", "type": "synonym", "evidence": [ { "id": "NP_001192509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509" } ] }, { "name": "IBA57", "type": "synonym", "evidence": [ { "id": "NP_001192509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509" } ] } ], "protein_names": [ { "name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BC94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC94/entry#names_and_taxonomy" } ] }, { "name": "IBA57 homolog, iron-sulfur cluster assembly", "type": "synonym", "evidence": [ { "id": "NP_001192509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509" } ] }, { "name": "IBA57, iron-sulfur cluster assembly homolog", "type": "synonym", "evidence": [ { "id": "NP_001192509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509" } ] }, { "name": "Iron-sulfur cluster assembly factor homolog", "type": "synonym", "evidence": [ { "id": "E1BC94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC94/entry#names_and_taxonomy" } ] }, { "name": "iron-sulfur cluster assembly factor IBA57, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001192509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509" } ] } ], "function": [ { "annotation": "Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway. Operates in cooperation with ISCA2 in the maturation of [4Fe-4S] proteins.", "evidence": [ { "database": "UniProtKB", "id": "E1BC94", "url": "https://www.uniprot.org/uniprotkb/E1BC94#function" }, { "database": "UniProtKB", "id": "ARBA00093401", "url": "https://www.uniprot.org/uniprotkb/ARBA00093401#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC94", "url": "https://www.uniprot.org/uniprotkb/E1BC94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IBA57", "url": "https://www.uniprot.org/uniprotkb/E1BC94", "locus": { "chromosome": "7", "start_pos": 2956083, "end_pos": 2967001, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014918", "url": "https://www.ensembl.org/id/ENSBTAG00000014918" } ] } } ], "crossref": [ { "id": "E1BC94", "url": "https://alphafold.ebi.ac.uk/entry/E1BC94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506009", "url": "https://www.ncbi.nlm.nih.gov/gene/506009", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506009", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506009", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MDRLHGV", "url": "https://omabrowser.org/oma/group/MDRLHGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC94", "url": "https://www.orthodb.org/?gene=E1BC94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22602", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22602", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22602:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22602:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192509", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BC94", "url": "https://www.uniprot.org/uniprotkb/E1BC94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC94-1", "url": "https://www.uniprot.org/uniprotkb/E1BC94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAALLRGAAPGCGGPAWSWRLRAAPRRHLAHSGCCQGADSASGATWACFLLGERALVRVRGPDSAPFLLGLLTNELPLPGPAVGEASTSARAGYAHFLNVQGRTLYDVILYGLPERSSEQPTFLLECDSSVVDALQRHLLLHKIRRKVTVEPCPELRVWAVLPCAQREAGGAGPLRKKTVCAPVLTRDPRTYRMGWRLLSQDEGSALVPGGRLGDLQDYHRHRYQQGVPEGVHDLPPGVALPLESNLAFMNGISFTKGCYIGQELTARTHHMGVIRKRLFPVQFSGAVPGGGIAPGASVLTESGQAAGKYRAGLGDVGLALLRSEKIKGPLHIRTSESGLVALTASVPDWWPTATK", "length": 358, "header": "tr|E1BC94-1|E1BC94_BOVIN Isoform 1 of Iron-sulfur cluster assembly factor IBA57, mitochondrial OS=Bos taurus OX=9913 GN=IBA57 PE=3 SV=1 CANONICAL=E1BC94-1" }, "isoforms": [ { "isoform_ac": "E1BC94-1", "url": "https://www.uniprot.org/uniprotkb/E1BC94/entry", "sequence": { "sequence": "MAAAALLRGAAPGCGGPAWSWRLRAAPRRHLAHSGCCQGADSASGATWACFLLGERALVRVRGPDSAPFLLGLLTNELPLPGPAVGEASTSARAGYAHFLNVQGRTLYDVILYGLPERSSEQPTFLLECDSSVVDALQRHLLLHKIRRKVTVEPCPELRVWAVLPCAQREAGGAGPLRKKTVCAPVLTRDPRTYRMGWRLLSQDEGSALVPGGRLGDLQDYHRHRYQQGVPEGVHDLPPGVALPLESNLAFMNGISFTKGCYIGQELTARTHHMGVIRKRLFPVQFSGAVPGGGIAPGASVLTESGQAAGKYRAGLGDVGLALLRSEKIKGPLHIRTSESGLVALTASVPDWWPTATK", "length": 358, "header": "tr|E1BC94-1|E1BC94_BOVIN Isoform 1 of Iron-sulfur cluster assembly factor IBA57, mitochondrial OS=Bos taurus OX=9913 GN=IBA57 PE=3 SV=1 CANONICAL=E1BC94-1" }, "locus": { "chromosome": "7", "start_pos": 2966802, "end_pos": 2957070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019861.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019861.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019861.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019861.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506009", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506009", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B8JMH0-1", "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "iba57", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQRMILFGGALREIVVRSGGLQAHYFLCTSRTRIKTHSQTRAASSTAHFSCYRLPHRTVLNVSGQDTSSFLQGIITNDMNLLGEDSLNAMYAHVLNVQGRTLYDIILYSLKGNPDGLNGVLLECDSTVQDSVMQLLKVYKIRRKVNLSVCPSLSLWALLPHSKEAVLGRPDVTTTDKVLVLEKDPRTELMGWRMITSAQDNPLDIVSACRLGNTEEYHRHRYEIGLPEGVGDLPPGEALPLEANLVYMQGISFSKGCYIGQELTARTHHTGVIRKRLMPVSLSAPAEKLNQGSALQTEGGKPAGKYRTGVDKLGLSLVRLAHAKETLQLKSSGDETVTVLASVPDWWPKTPQEK", "length": 354 }, "evidence": [ { "id": "E1BC94", "url": "https://omabrowser.org/oma/group/E1BC94/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D4ADG2-1", "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "Iba57", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVALLRGAAAGRKSPAWQWRPSGTTRHCPVRGSGLFRGNSTDSVAWTCFRLDGRALMRVRGPDASPFLLGLLTNELPLSGPPAGATQPSARAAYAHFLNVQGRTLYDVIVYGLPECTEEAPGFLLECDSSVLGTLQKYLTMYKIRRKVAVEPHPELHVWAVLPCAPQTSEAAPLEERVEATTMLIRDPRTARMGWRLLTQDGGPAVVPRGQLGDLQDYHIYRYQQGIPEGVCDLPPGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKLEGPLPASGISPGTLVTVTATGQAAGKFRAGQGHIGLALLRSETIKGPLHIKTSESQLVAVTAMVPDWWPTAAK", "length": 358 }, "evidence": [ { "id": "E1BC94", "url": "https://omabrowser.org/oma/group/E1BC94/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T440-1", "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "IBA57", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATAALLRGATPGRGGPVWRWRLRAAPRCRLAHSSCSPGGDPTAGAAWACFRLDGRTLLRVRGPDAAPFLLGLLTNELPLPSPAAAGAPPAARAGYAHFLNVQGRTLYDVILYGLQEHSEVSGFLLECDSSVQGALQKHLALYRIRRKVTVEPHPELRVWAVLPSSPEACGAASLQERAGAAAILIRDPRTARMGWRLLTQDEGPALVPGGRLGDLWDYHQHRYLQGVPEGVRDLPPGVALPLESNLAFMNGVSFTKGCYIGQELTARTHHMGVIRKRLFPVRFLDPLPTSGITPGATVLTASGQTVGKFRAGQGNVGLALLWSEKIKGPLHIRASEGAQVALAASVPDWWPTVSK", "length": 356 }, "evidence": [ { "id": "E1BC94", "url": "https://omabrowser.org/oma/group/E1BC94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CAK1-1", "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "Iba57", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVALLRGAAVGRRSPAWHWRLSGTASHCLARGFGLLGSNPADGVAWTCFRLDGRALVRVRGPDAAPFLLGLSTNELPLSGPPTGAAQPSARAAYAHFLNVQGRTLYDVILYGLPECTEGAPSFLLECDSSVLGALQKHLSMYKIRRKVTVEPSPELHVWAVLPCVPQTSETAPLEERVEGTTMLIRDPRTARMGWRLLTQDDGPALVPRGQLGDLQDYHKYRYQQGIPEGVCDLPPGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVIRKRLFPVKLEGPLPASGVSPGAIVTVTATGQAAGKFRAGQGHVGLALLRSETIKGPLHIKTSESQLVAVTAVVPDWWPTAAK", "length": 358 }, "evidence": [ { "id": "E1BC94", "url": "https://omabrowser.org/oma/group/E1BC94/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8L733-1", "protein_name": "Putative transferase At4g12130, mitochondrial", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MFRFNFRREISKYTGIYHRKIHSGLEDAGPMASRLKSRSVVRFSGPDTVKFLQGLLTNDVRRFGESSGEKNSAVPTPNMASVTNPPMYAALLTPQGRFLYDFFLYSPSRPDEKLDRTGSGPGSDSGRDGSVELFADVDVDVLDELLETLKKYRLRSKVDIENVAEEFSCWQRYGRNLTGSSSVGWGGGVDRAGESTASGNKYGWQWYKDPRLECLGYRSIFPSDATPPLVEADKETDESNYLLWRLEHGVAEGSAEIPKGEAIPLEYNFVGLNAISFDKGCYVGQELIARTHHRGVIRKRLIPLRFIDSNGKELNQKIAAGAEVVESGTGKKMGTVSTALGSRGMGVMRVEEAFKPSAELAVKDSEEVKVEAIKPTWWPAEWFQQNQSGVAAA", "length": 393 }, "evidence": [ { "id": "E1BC94", "url": "https://omabrowser.org/oma/group/E1BC94/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VHN4-1", "protein_name": "CAF17 C-terminal domain-containing protein", "gene_name": "Dmel\\CG8043", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNRCSNPWFLRAVRHHIRNLHEMRIPYARPVGPNQRNFTLEPLGNRELIRVHGAEVVPFLQGLATNDVARIQSPGGPASMYAHFLNKAGRLLYDTILYRTNNPETILVECDREASSDFRRHLRTYRVRRRIEVDSVDDEYTPWVMFNLKDASEAVPNPHPDLFVSPDPRLHVLGTRILAPTDMDWSKLSKCFADFGTATAASSDNSYQLLRYKQGVGEGCSELTPGKCFPLEANADYLHGVSFHKGCYVGQELTARVHHSGVIRKRYMPIRLTAPIDVGSSQDVTSLAGAKLGRVFGFAHKHGIALLRIEKVLNGRPELMIDGERCYVERPEWWPEDLPGKRRMAFAE", "length": 348 }, "evidence": [ { "id": "E1BC94", "url": "https://omabrowser.org/oma/group/E1BC94/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1BC94", "url": "https://www.uniprot.org/uniprotkb/E1BC94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "heme biosynthetic process", "id": "GO:0006783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006783", "evidence": [ { "database": "UniProtKB", "id": "E1BC94", "url": "https://www.uniprot.org/uniprotkb/E1BC94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC94-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC94-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC94" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC94" }, { "id": "PF25455", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25455" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CAF17 C-terminal", "eco_id": "ECO_0000259", "start_pos": 278, "end_pos": 354, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCA5-1", "uniprot_ac": "E1BCA5", "uniprot_id": "E1BCA5_BOVIN", "mass": { "chemical_mass": 46343.0, "monoisotopic_mass": 46343.0 }, "refseq": { "ac": "NP_001179167", "name": "neuroserpin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179167" }, "gene_names": [ { "name": "SERPINI1", "type": "recommended", "evidence": [ { "id": "E1BCA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCA5" } ] }, { "name": "SERPINI1", "type": "synonym", "evidence": [ { "id": "NP_001179167", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179167" } ] } ], "protein_names": [ { "name": "Serpin family I member 1", "type": "synonym", "evidence": [ { "id": "E1BCA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCA5/entry#names_and_taxonomy" } ] }, { "name": "neuroserpin precursor", "type": "synonym", "evidence": [ { "id": "NP_001179167", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179167" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCA5", "url": "https://www.uniprot.org/uniprotkb/E1BCA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINI1", "url": "https://www.uniprot.org/uniprotkb/E1BCA5", "locus": { "chromosome": "1", "start_pos": 99660456, "end_pos": 99743550, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012708", "url": "https://www.ensembl.org/id/ENSBTAG00000012708" } ] } } ], "crossref": [ { "id": "E1BCA5", "url": "https://alphafold.ebi.ac.uk/entry/E1BCA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012708", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012708", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02048", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02048", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509976", "url": "https://www.ncbi.nlm.nih.gov/gene/509976", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509976", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509976", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IQNGFHV", "url": "https://omabrowser.org/oma/group/IQNGFHV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCA5", "url": "https://www.orthodb.org/?gene=E1BCA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179167", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCA5", "url": "https://www.uniprot.org/uniprotkb/E1BCA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFLGLFSLLVLQSLALGTTFTDETIAELSVNMYNHLRATGEDENILFSPLSVTLAMGMLELGAQGSTLKEIRHSMGYDSLKNGEEFSFLKDLSHMVTAEESQYVMKIANSLFVQNGFHISEEFLQMIKKYFNAEVNHVDFSQNVAVANYINKWVENNTNSLLKDLVSPRDFDAVTHLALINAVYFKGSWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDAISMMLVLSRQEVPLATLEPLVKTQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGVTEVFIKNANLTALSDNKEIFLSKAIHKCFIEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNASGHDFEEL", "length": 410, "header": "tr|E1BCA5-1|E1BCA5_BOVIN Isoform 1 of Serpin family I member 1 OS=Bos taurus OX=9913 GN=SERPINI1 PE=3 SV=2 CANONICAL=E1BCA5-1" }, "isoforms": [ { "isoform_ac": "E1BCA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCA5/entry", "sequence": { "sequence": "MAFLGLFSLLVLQSLALGTTFTDETIAELSVNMYNHLRATGEDENILFSPLSVTLAMGMLELGAQGSTLKEIRHSMGYDSLKNGEEFSFLKDLSHMVTAEESQYVMKIANSLFVQNGFHISEEFLQMIKKYFNAEVNHVDFSQNVAVANYINKWVENNTNSLLKDLVSPRDFDAVTHLALINAVYFKGSWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDAISMMLVLSRQEVPLATLEPLVKTQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGVTEVFIKNANLTALSDNKEIFLSKAIHKCFIEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNASGHDFEEL", "length": 410, "header": "tr|E1BCA5-1|E1BCA5_BOVIN Isoform 1 of Serpin family I member 1 OS=Bos taurus OX=9913 GN=SERPINI1 PE=3 SV=2 CANONICAL=E1BCA5-1" }, "locus": { "chromosome": "1", "start_pos": 99691600, "end_pos": 99660710, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016890.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016890.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016890.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016890.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509976", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509976", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SH33-1", "protein_name": "Serpin family I member 1", "gene_name": "SERPINI1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFLGFFSLLVLQSLALGTTFTDETITEFSVNMYNHLRATGEDENILFSPLSVTLAMGMLELGAQGSTLKEIRHSMGYESLKSGEEFSFLKDLSHMVTAEESQYVMKIANSLFVQNGFHVNDEFLQMLKKYFNAEVNHVDFSQNVAVANYINKWVENNTNSLLKDLLSPTDFDAVTHLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLLEEWANSVKKQKVEVYLPRFTVEQEVDLKNVLKALGITEVFIKNANLTALSDNKEIFLSKAIHKSFIEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFFFLIRNRRSGTILFMGRVMHPETMNTSGHDFEEL", "length": 410 }, "evidence": [ { "id": "E1BCA5", "url": "https://omabrowser.org/oma/group/E1BCA5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35684-1", "protein_name": "Neuroserpin", "gene_name": "Serpini1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTYLELLALLALQSVVTGATFPDETITEWSVNMYNHLRGTGEDENILFSPLSIALAMGMMELGAQGSTRKEIRHSMGYEGLKGGEEFSFLRDFSNMASAEENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTNSLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKSCIEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFLYLIRNRKSGIILFMGRVMNPETMNTSGHDFEEL", "length": 410 }, "evidence": [ { "id": "E1BCA5", "url": "https://omabrowser.org/oma/group/E1BCA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q90935-1", "protein_name": "Neuroserpin", "gene_name": "SERPINI1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYFLGLLSLLVLPSKAFKTNFPDETIAELSVNVYNQLRAAREDENILFCPLSIAIAMGMIELGAHGTTLKEIRHSLGFDSLKNGEEFTFLKDLSDMATTEESHYVLNMANSLYVQNGFHVSEKFLQLVKKYFKAEVENIDFSQSAAVATHINKWVENHTNNMIKDFVSSRDFSALTHLVLINAIYFKGNWKSQFRPENTRTFSFTKDDETEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMIVLSRQEVPLVTLEPLVKASLINEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKGLGITEVFSRSADLTAMSDNKELYLAKAFHKAFLEVNEEGSEAAAASGMIAISRMAVLYPQVIVDHPFFFLVRNRRTGTVLFMGRVMHPEAMNTSGHDFEEL", "length": 410 }, "evidence": [ { "id": "E1BCA5", "url": "https://omabrowser.org/oma/group/E1BCA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q99574-1", "protein_name": "Neuroserpin", "gene_name": "SERPINI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL", "length": 410 }, "evidence": [ { "id": "E1BCA5", "url": "https://omabrowser.org/oma/group/E1BCA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JLD2-1", "protein_name": "Neuroserpin", "gene_name": "Serpini1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAYLGLLSLVALQSLVTGAAFPDETIAEWSVNVYNHLRATGEDENILFSPLSIALAMGVMELGAQGSTLKEIRHSMGYESLKSGEEFSFLRDFSSMVSAEEGQYVMKIANSLFVQNGFHINEEFLQMMKMYFNAEVNHVDFSENVAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLLKPQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKSFIEVNEEGSEAAVASGMIAISRMAVLFPQVIVDHPFLFLIKNRKTGTILFMGRVMHPETMNTSGHDFEEL", "length": 410 }, "evidence": [ { "id": "E1BCA5", "url": "https://omabrowser.org/oma/group/E1BCA5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9S7T8-1", "protein_name": "Serpin-ZX", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDVRESISLQNQVSMNLAKHVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFSSTDQLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAASNQADFQSKAVEVIAEVNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNEKFDESLTQEGEFHLLDGNKVTAPFMTSKKKQYVSAYDGFKVLGLPYLQGQDKRQFSMYFYLPDANNGLSDLLDKIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTSPFSGEEGLTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDEIDFVADHPFLLVVTENITGVVLFIGQVVDPLH", "length": 391 }, "evidence": [ { "id": "E1BCA5", "url": "https://omabrowser.org/oma/group/E1BCA5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1BCA5", "url": "https://www.uniprot.org/uniprotkb/E1BCA5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BCA5", "url": "https://www.uniprot.org/uniprotkb/E1BCA5" } ], "pmid": "" }, { "name": "secretory granule lumen", "id": "GO:0034774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034774", "evidence": [ { "database": "UniProtKB", "id": "E1BCA5", "url": "https://www.uniprot.org/uniprotkb/E1BCA5" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "E1BCA5", "url": "https://www.uniprot.org/uniprotkb/E1BCA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 410, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCA5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 401, "end_pos": 403 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCB2-1", "uniprot_ac": "E1BCB2", "uniprot_id": "E1BCB2_BOVIN", "mass": { "chemical_mass": 30811.0, "monoisotopic_mass": 30811.0 }, "refseq": { "ac": "NP_001179185", "name": "receptor-transporting protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179185" }, "gene_names": [ { "name": "RTP1", "type": "recommended", "evidence": [ { "id": "E1BCB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ] }, { "name": "RTP1", "type": "synonym", "evidence": [ { "id": "NP_001179185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179185" } ] } ], "protein_names": [ { "name": "Receptor transporter protein 1", "type": "synonym", "evidence": [ { "id": "E1BCB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB2/entry#names_and_taxonomy" } ] }, { "name": "receptor-transporting protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179185" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTP1", "url": "https://www.uniprot.org/uniprotkb/E1BCB2", "locus": { "chromosome": "1", "start_pos": 80081558, "end_pos": 80127927, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012706", "url": "https://www.ensembl.org/id/ENSBTAG00000012706" } ] } } ], "crossref": [ { "id": "E1BCB2", "url": "https://alphafold.ebi.ac.uk/entry/E1BCB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012706", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012706", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510430", "url": "https://www.ncbi.nlm.nih.gov/gene/510430", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510430", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510430", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDFIIDP", "url": "https://omabrowser.org/oma/group/WDFIIDP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCB2", "url": "https://www.orthodb.org/?gene=E1BCB2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14402", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14402", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14402:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14402:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13695", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13695", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179185", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCB2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRIFRPWRLRCPALHLPSLPVFSLKWSLPSLAPDETMCKSVTTDEWKKIFYEKMEEAKPADSWDLIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQSPHLVILFHMYLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIECLVDNLITSLREQCYGERGGQYRIHVASRQDTRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKPQAEEGSGCNFFSIPWCLFWATVLLLIIYLQFSFRSSV", "length": 263, "header": "tr|E1BCB2-1|E1BCB2_BOVIN Isoform 1 of Receptor transporter protein 1 OS=Bos taurus OX=9913 GN=RTP1 PE=4 SV=1 CANONICAL=E1BCB2-1" }, "isoforms": [ { "isoform_ac": "E1BCB2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCB2/entry", "sequence": { "sequence": "MRIFRPWRLRCPALHLPSLPVFSLKWSLPSLAPDETMCKSVTTDEWKKIFYEKMEEAKPADSWDLIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQSPHLVILFHMYLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIECLVDNLITSLREQCYGERGGQYRIHVASRQDTRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKPQAEEGSGCNFFSIPWCLFWATVLLLIIYLQFSFRSSV", "length": 263, "header": "tr|E1BCB2-1|E1BCB2_BOVIN Isoform 1 of Receptor transporter protein 1 OS=Bos taurus OX=9913 GN=RTP1 PE=4 SV=1 CANONICAL=E1BCB2-1" }, "locus": { "chromosome": "1", "start_pos": 80085391, "end_pos": 80082562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016889.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016889.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016889.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016889.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510430", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510430", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BQV7-1", "protein_name": "Receptor transporter protein 1", "gene_name": "RTP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRIFRPWRLRCPALHLPSLPVFSLKWSLPSLTTDETMCKSVTTEEWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQSPHVVILFHMHLDRAQRAGSVRMRVFKQLCYECGTSRLDESSMLEENIESLVDNLITSLREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKQQAEGGSGCNFCSIPWCLFWATVLLLIIYLQFSFRSSV", "length": 263 }, "evidence": [ { "id": "E1BCB2", "url": "https://omabrowser.org/oma/group/E1BCB2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7HTM7-1", "protein_name": "Receptor-transporting protein 1", "gene_name": "Rtp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRIFRPWRLRCPALHLPSLPTFSIKWSLPSLTTDEDMCKSVTTGEWKKVFYEKMEEAKPADSWDFIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQSPHVVILFHMYLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIESLVDNLITSLREQCYGERGGHYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKPQTETSSGCNFCSIPWCLFWATVLLLIIYLQFSFRSSV", "length": 263 }, "evidence": [ { "id": "E1BCB2", "url": "https://omabrowser.org/oma/group/E1BCB2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4AEN1-1", "protein_name": "Receptor (chemosensory) transporter protein 1", "gene_name": "Rtp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRIFRPWRLRCPALHLPSFPTFSIKWSLPSLPTDEDMCKSVTTGEWKKVFYEKMEEVKPADSWDFIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQSPHVVILFHMYLDKAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIESLVDNLITSLREQCYGERGGHYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKPQAETGSGCNFCSIPWCLFWATVLLLIIYLQFSFRSSV", "length": 263 }, "evidence": [ { "id": "E1BCB2", "url": "https://omabrowser.org/oma/group/E1BCB2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P59025-1", "protein_name": "Receptor-transporting protein 1", "gene_name": "RTP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRIFRPWRLRCPALHLPSLSVFSLRWKLPSLTTDETMCKSVTTDEWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQSPYVVILFHMFLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKSQDQTGSGWNFCSIPWCLFWATVLLLIIYLQFSFRSSV", "length": 263 }, "evidence": [ { "id": "E1BCB2", "url": "https://omabrowser.org/oma/group/E1BCB2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C8C1-1", "protein_name": "Receptor-transporting protein 1", "gene_name": "Rtp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRIFRPWRLRCPALHLPSFPTFSIKCSLPPLPTDEDMCKSVTTGEWKKVFYEKMEEVKPADSWDFIIDPNLKHNVLAPGWKQYLELHASGRFHCSWCWHTWQSPHVVILFHMYLDKAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIESLVDNLITSLREQCYGERGGHYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFSRAPSPTKPQAETGSGCNFCSIPWCLFWATVLMLIIYLQFSFRTSV", "length": 263 }, "evidence": [ { "id": "E1BCB2", "url": "https://omabrowser.org/oma/group/E1BCB2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" }, { "name": "olfactory receptor binding", "id": "GO:0031849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031849", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" }, { "name": "protein insertion into membrane", "id": "GO:0051205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051205", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" }, { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "E1BCB2", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCB2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 263, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCB2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCB2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB2" }, { "id": "SM01328", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01328" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3CxxC-type", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 197, "start_aa": "His", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCB9-1", "uniprot_ac": "E1BCB9", "uniprot_id": "E1BCB9_BOVIN", "mass": { "chemical_mass": 66342.0, "monoisotopic_mass": 66342.0 }, "refseq": {}, "gene_names": [ { "name": "EFCAB12", "type": "recommended", "evidence": [ { "id": "E1BCB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB9" } ] } ], "protein_names": [ { "name": "EF-hand calcium binding domain 12", "type": "synonym", "evidence": [ { "id": "E1BCB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCB9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCB9", "url": "https://www.uniprot.org/uniprotkb/E1BCB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB12", "url": "https://www.uniprot.org/uniprotkb/E1BCB9", "locus": { "chromosome": "22", "start_pos": 56343442, "end_pos": 56325258, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021643", "url": "https://www.ensembl.org/id/ENSBTAG00000021643" } ] } } ], "crossref": [ { "id": "E1BCB9", "url": "https://alphafold.ebi.ac.uk/entry/E1BCB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021643", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021643", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47225", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47225", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47225:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47225:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "E1BCB9", "url": "https://www.uniprot.org/uniprotkb/E1BCB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDDSNEEYEAAFRSLLRFYQSKSLLDDENASKEPVFNPEAVIAHCFKQFKQEDFHLPRSRRRVIILPQKEAPKPVRPTPQLQTPLEPTPSPKAPEVGDTQEQPEDPRAWLRQRLKMRKDLESFGNVERWLQNKANLTLSKAKVLRDIHKKQAAEPLAMIRDTAKKSQQPSRRQVPQLRLPKPPALSTLYSYLHCRKIKILELFHKVDQGKHQISREEFIVALKAIGVPLKNQEVEDIVVYLSSLGKHNSITMDNLASTYKQWSLARQQSTLTIATEDSRSSNDSGSTQSSSPKQKANVPPEAPKMDLLTVPVVDTEMEARPMTLEEMEDVGKHYRERKRQNKLALPSIQYTEQCRLVRSGDKHFDEHCLPTTVHGEMGSILNRSRVDTFLVYLQCWKVCEAHGLPLTEDILMRALMYPGDKIIFQKDEMRPIRQPGGYYSDFKPFTENLALVRPQGVPVPVPQKKPDKKMPKKIKKINFKEFEEFTRKLKEKKPSSPQLTHPNFFWPGHLLDKLRLYLPTVTMDRSLAIFSCVQQRPHVYPATYHSDCWWPIKDVNYVTYAYYDAHKIYHIN", "length": 572, "header": "tr|E1BCB9-1|E1BCB9_BOVIN Isoform 1 of EF-hand calcium binding domain 12 OS=Bos taurus OX=9913 GN=EFCAB12 PE=4 SV=3 CANONICAL=E1BCB9-1" }, "isoforms": [ { "isoform_ac": "E1BCB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCB9/entry", "sequence": { "sequence": "MDDSNEEYEAAFRSLLRFYQSKSLLDDENASKEPVFNPEAVIAHCFKQFKQEDFHLPRSRRRVIILPQKEAPKPVRPTPQLQTPLEPTPSPKAPEVGDTQEQPEDPRAWLRQRLKMRKDLESFGNVERWLQNKANLTLSKAKVLRDIHKKQAAEPLAMIRDTAKKSQQPSRRQVPQLRLPKPPALSTLYSYLHCRKIKILELFHKVDQGKHQISREEFIVALKAIGVPLKNQEVEDIVVYLSSLGKHNSITMDNLASTYKQWSLARQQSTLTIATEDSRSSNDSGSTQSSSPKQKANVPPEAPKMDLLTVPVVDTEMEARPMTLEEMEDVGKHYRERKRQNKLALPSIQYTEQCRLVRSGDKHFDEHCLPTTVHGEMGSILNRSRVDTFLVYLQCWKVCEAHGLPLTEDILMRALMYPGDKIIFQKDEMRPIRQPGGYYSDFKPFTENLALVRPQGVPVPVPQKKPDKKMPKKIKKINFKEFEEFTRKLKEKKPSSPQLTHPNFFWPGHLLDKLRLYLPTVTMDRSLAIFSCVQQRPHVYPATYHSDCWWPIKDVNYVTYAYYDAHKIYHIN", "length": 572, "header": "tr|E1BCB9-1|E1BCB9_BOVIN Isoform 1 of EF-hand calcium binding domain 12 OS=Bos taurus OX=9913 GN=EFCAB12 PE=4 SV=3 CANONICAL=E1BCB9-1" }, "locus": { "chromosome": "22", "start_pos": 56343080, "end_pos": 56325258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028840.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028840.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028840.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028840.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 78, "start_aa": "Thr", "end_pos": 78, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr78", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 88, "start_aa": "Thr", "end_pos": 88, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr88", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 572, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCB9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 78, 88 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 382, "end_pos": 384 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCC0-1", "uniprot_ac": "E1BCC0", "uniprot_id": "E1BCC0_BOVIN", "mass": { "chemical_mass": 41916.0, "monoisotopic_mass": 41916.0 }, "refseq": {}, "gene_names": [ { "name": "FAM186A", "type": "recommended", "evidence": [ { "id": "E1BCC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC0" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 186 member A", "type": "synonym", "evidence": [ { "id": "E1BCC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCC0", "url": "https://www.uniprot.org/uniprotkb/E1BCC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM186A", "url": "https://www.uniprot.org/uniprotkb/E1BCC0", "locus": { "chromosome": "5", "start_pos": 29591802, "end_pos": 29563404, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023546", "url": "https://www.ensembl.org/id/ENSBTAG00000023546" } ] } } ], "crossref": [ { "id": "E1BCC0", "url": "https://alphafold.ebi.ac.uk/entry/E1BCC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023546", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023546", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR049146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCC0", "url": "https://www.orthodb.org/?gene=E1BCC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33590", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33590", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33590:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33590:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20865", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20865", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BCC0", "url": "https://www.uniprot.org/uniprotkb/E1BCC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TAEVSDTSEEIQIPKDPFAVKQFRMFKSHLTDYKTPVSQAPYVDEGTLPATLIKPVTPLPSLITTQLLKTRQSSPSEWDQKSQLPPINKPWVLTSVSDTKQPKMMVPTSYPQELKEQNYFVDVEAQRKNLILLNQAAKSSILPSQLHTEARNLIIETFHTDKVRLGYLFRKYNAYRLIQRARNNIIKRLQAIQITGRSYETQNLYIMLKRIDDYQKKIMQIWTEKQNSLEQKRNQCLRKMMYLFSQLQETYKLNLDQPIPLVIEQKQKPASTKSVQQPCPKLLKEDNRKYNILNKFRKDDQLQAIWNADLSTSSYPITEKTSMHPFWAQLGGYPDIPMLLQLDVQSAFIRSLTCIQSSSSG", "length": 361, "header": "tr|E1BCC0-1|E1BCC0_BOVIN Isoform 1 of Family with sequence similarity 186 member A OS=Bos taurus OX=9913 GN=FAM186A PE=4 SV=4 CANONICAL=E1BCC0-1" }, "isoforms": [ { "isoform_ac": "E1BCC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC0/entry", "sequence": { "sequence": "TAEVSDTSEEIQIPKDPFAVKQFRMFKSHLTDYKTPVSQAPYVDEGTLPATLIKPVTPLPSLITTQLLKTRQSSPSEWDQKSQLPPINKPWVLTSVSDTKQPKMMVPTSYPQELKEQNYFVDVEAQRKNLILLNQAAKSSILPSQLHTEARNLIIETFHTDKVRLGYLFRKYNAYRLIQRARNNIIKRLQAIQITGRSYETQNLYIMLKRIDDYQKKIMQIWTEKQNSLEQKRNQCLRKMMYLFSQLQETYKLNLDQPIPLVIEQKQKPASTKSVQQPCPKLLKEDNRKYNILNKFRKDDQLQAIWNADLSTSSYPITEKTSMHPFWAQLGGYPDIPMLLQLDVQSAFIRSLTCIQSSSSG", "length": 361, "header": "tr|E1BCC0-1|E1BCC0_BOVIN Isoform 1 of Family with sequence similarity 186 member A OS=Bos taurus OX=9913 GN=FAM186A PE=4 SV=4 CANONICAL=E1BCC0-1" }, "locus": { "chromosome": "5", "start_pos": 29591799, "end_pos": 29563404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032158.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032158.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032096.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032096.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCC0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 361, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCC0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCC0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC0" }, { "id": "PF20865", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM186A/B C-terminal", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 343, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCC4-1", "uniprot_ac": "E1BCC4", "uniprot_id": "E1BCC4_BOVIN", "mass": { "chemical_mass": 53332.0, "monoisotopic_mass": 53332.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112442214", "type": "recommended", "evidence": [ { "id": "E1BCC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ] } ], "protein_names": [ { "name": "Zinc finger protein 160", "type": "recommended", "evidence": [ { "id": "E1BCC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112442214", "url": "https://www.uniprot.org/uniprotkb/E1BCC4", "locus": {} } ], "crossref": [ { "id": "E1BCC4", "url": "https://alphafold.ebi.ac.uk/entry/E1BCC4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033523", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033523", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803204", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QQMTVEDVAIKFTPEEWECLSPAQRTLYWDVMLETYRNLLSVDISPIHIIKKLQSGEHTDTLQTVILGRHESHGVQDFYLREIRGNTLEFECQWKDDERNYKGVLVIHNEKLTDRKDQRGRSNAGNNAIENKLALSFQDELQIFRMERKIFECNQVENVINNSSSISALQRIPPSVQTNTSNMYGNNFIHSSILTKDHKAHREKPYRCNDCDKTFTHVSHLTKHQVVHTGERPYKCDTCGKDFSQSSNLATHRRIHTGEKPYKCNECGKDFNRKSNLETHQRIHTGEKPYKCNVCGKAFRVCSSLRSHQVIHTGEKDYHCSKCNKAFSRNSKLLKHQRIHTRGQPYKCDACDKAFILRSSLINHQVVHTRGKSYPCNECGKMFIKRSHLRLHERIHTGEKPYKCTECGKGFRQWSDIRIHLRIHAGEKPFKCSKCGKSFTRSSHLTRHQIIHTGEKPY", "length": 458, "header": "tr|E1BCC4-1|E1BCC4_BOVIN Isoform 1 of Zinc finger protein 160 OS=Bos taurus OX=9913 GN=LOC112442214 PE=3 SV=4 CANONICAL=E1BCC4-1" }, "isoforms": [ { "isoform_ac": "E1BCC4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC4/entry", "sequence": { "sequence": "QQMTVEDVAIKFTPEEWECLSPAQRTLYWDVMLETYRNLLSVDISPIHIIKKLQSGEHTDTLQTVILGRHESHGVQDFYLREIRGNTLEFECQWKDDERNYKGVLVIHNEKLTDRKDQRGRSNAGNNAIENKLALSFQDELQIFRMERKIFECNQVENVINNSSSISALQRIPPSVQTNTSNMYGNNFIHSSILTKDHKAHREKPYRCNDCDKTFTHVSHLTKHQVVHTGERPYKCDTCGKDFSQSSNLATHRRIHTGEKPYKCNECGKDFNRKSNLETHQRIHTGEKPYKCNVCGKAFRVCSSLRSHQVIHTGEKDYHCSKCNKAFSRNSKLLKHQRIHTRGQPYKCDACDKAFILRSSLINHQVVHTRGKSYPCNECGKMFIKRSHLRLHERIHTGEKPYKCTECGKGFRQWSDIRIHLRIHAGEKPFKCSKCGKSFTRSSHLTRHQIIHTGEKPY", "length": 458, "header": "tr|E1BCC4-1|E1BCC4_BOVIN Isoform 1 of Zinc finger protein 160 OS=Bos taurus OX=9913 GN=LOC112442214 PE=3 SV=4 CANONICAL=E1BCC4-1" }, "locus": { "chromosome": "18", "start_pos": 58374539, "end_pos": 58368916, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016870.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016870.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016870.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016870.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-6803204", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803204", "resource": "Reactome", "description": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BCC4", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCC4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 458, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCC4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCC4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 206, "end_pos": 233, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BCC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC4" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 72, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 179, "end_pos": 181 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCE3-1", "uniprot_ac": "E1BCE3", "uniprot_id": "E1BCE3_BOVIN", "mass": { "chemical_mass": 34885.0, "monoisotopic_mass": 34885.0 }, "refseq": { "ac": "NP_001376878", "name": "olfactory receptor family 2 subfamily M member 16", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878" }, "gene_names": [ { "name": "OR2M16", "type": "recommended", "evidence": [ { "id": "E1BCE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" } ] }, { "name": "OR2M16", "type": "synonym", "evidence": [ { "id": "NP_001376878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878" } ] }, { "name": "OR2M5", "type": "synonym", "evidence": [ { "id": "NP_001376878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 2 subfamily M member 16", "type": "synonym", "evidence": [ { "id": "E1BCE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCE3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 2 subfamily M member 16", "type": "synonym", "evidence": [ { "id": "NP_001376878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878" } ] }, { "name": "olfactory receptor, family 2, subfamily M, member 5", "type": "synonym", "evidence": [ { "id": "NP_001376878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2M16", "url": "https://www.uniprot.org/uniprotkb/E1BCE3", "locus": { "chromosome": "7", "start_pos": 41935430, "end_pos": 41936365, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009497", "url": "https://www.ensembl.org/id/ENSBTAG00000009497" } ] } } ], "crossref": [ { "id": "E1BCE3", "url": "https://alphafold.ebi.ac.uk/entry/E1BCE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009497", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009497", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514645", "url": "https://www.ncbi.nlm.nih.gov/gene/514645", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514645", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514645", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FISMAGC", "url": "https://omabrowser.org/oma/group/FISMAGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCE3", "url": "https://www.orthodb.org/?gene=E1BCE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001376878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376878", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCE3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWEFQTFNSDFILLGIFDHRPTHIFLFSRVLGVSAVAIMGNTLVVLFLYLNAQLHTPMYFLLSQLSLTDLVLISTTIPKMAFNYLSGSKSITMADCATHIFFYASLTGCECFLLAVMAYDCDVATCHPLRYTSLMRLKICGLMTASSWVLGSTDGVIDAVVTFSFSCCGFWVIAHFFCDFPFLLVIQCNDTSIFEEVLFYCCIMMILFPVAIIIASYARVLLTVILMGSGKGRHRAFATCSSHLMVVGTYYGAVLFMYMRPASNHSPTQDRMMSVFYTILTPTLNPLIYSFRNKEVACAFQVFRKGKTGE", "length": 311, "header": "tr|E1BCE3-1|E1BCE3_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily M member 16 OS=Bos taurus OX=9913 GN=OR2M16 PE=3 SV=3 CANONICAL=E1BCE3-1" }, "isoforms": [ { "isoform_ac": "E1BCE3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCE3/entry", "sequence": { "sequence": "MAWEFQTFNSDFILLGIFDHRPTHIFLFSRVLGVSAVAIMGNTLVVLFLYLNAQLHTPMYFLLSQLSLTDLVLISTTIPKMAFNYLSGSKSITMADCATHIFFYASLTGCECFLLAVMAYDCDVATCHPLRYTSLMRLKICGLMTASSWVLGSTDGVIDAVVTFSFSCCGFWVIAHFFCDFPFLLVIQCNDTSIFEEVLFYCCIMMILFPVAIIIASYARVLLTVILMGSGKGRHRAFATCSSHLMVVGTYYGAVLFMYMRPASNHSPTQDRMMSVFYTILTPTLNPLIYSFRNKEVACAFQVFRKGKTGE", "length": 311, "header": "tr|E1BCE3-1|E1BCE3_BOVIN Isoform 1 of Olfactory receptor family 2 subfamily M member 16 OS=Bos taurus OX=9913 GN=OR2M16 PE=3 SV=3 CANONICAL=E1BCE3-1" }, "locus": { "chromosome": "7", "start_pos": 41936365, "end_pos": 41935433, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012496.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012496.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012496.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012496.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514645", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514645", "resource": "KEGG Pathway" }, { "id": "R-BTA-381753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "resource": "Reactome", "description": "Olfactory Signaling Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QQZ7-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100620490", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALENQTFNSDFILLGIFDHSPTHIFLFSLVLGIFTVAFMGNTIMILLIYLDTQLHTPMYFLLSQLSLMDLMLICTTVPKMAYNYLSGSTSISFAGCATQIFFYTSLLGCECFLLAVMAYDRNIAICHPLRYTNLMSPKICGLMVASSWILGSTDGVIDAVATFSFSYCGSREIAHFFCDFPFLLIISCNDTSIFEEVLFYCCIIMIVFPVAVVLVSYARVILAVIRMGSGKGRHKAFATCSSHLMVVGMYYGAGLFIYMRPTSNRSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVARAFMKVLGKGKN", "length": 310 }, "evidence": [ { "id": "E1BCE3", "url": "https://omabrowser.org/oma/group/E1BCE3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1BCE3", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCE3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCE3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCE3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCE3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 265, "end_pos": 267 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCE8-1", "uniprot_ac": "E1BCE8", "uniprot_id": "E1BCE8_BOVIN", "mass": { "chemical_mass": 32312.0, "monoisotopic_mass": 32312.0 }, "refseq": {}, "gene_names": [ { "name": "GRXCR1", "type": "recommended", "evidence": [ { "id": "E1BCE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ] } ], "protein_names": [ { "name": "Glutaredoxin domain-containing cysteine-rich protein 1", "type": "recommended", "evidence": [ { "id": "E1BCE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCE8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in actin filament architecture in developing stereocilia of sensory cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8#function" }, { "database": "UniProtKB", "id": "ARBA00054582", "url": "https://www.uniprot.org/uniprotkb/ARBA00054582#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRXCR1", "url": "https://www.uniprot.org/uniprotkb/E1BCE8", "locus": { "chromosome": "6", "start_pos": 61829436, "end_pos": 61696746, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032947", "url": "https://www.ensembl.org/id/ENSBTAG00000032947" } ] } } ], "crossref": [ { "id": "E1BCE8", "url": "https://alphafold.ebi.ac.uk/entry/E1BCE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032947", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03031", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03031", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ACHGSKM", "url": "https://omabrowser.org/oma/group/ACHGSKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCE8", "url": "https://www.orthodb.org/?gene=E1BCE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46990", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46990", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46990:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46990:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23733", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23733", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCE8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKREVKPETDRPRKVRFRIASSHSGRVLREVYEDGRPAGSLDSECASICGLDGLSESDGQQNGHIGSEGDEQENDQDNLLVLARAASEKGFGTRRVNILSKNGTIRGVKYKVSAGQALFNNLTKVLQQPSTELEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDSFKALKCTACNENGLQRCKSCVG", "length": 290, "header": "tr|E1BCE8-1|E1BCE8_BOVIN Isoform 1 of Glutaredoxin domain-containing cysteine-rich protein 1 OS=Bos taurus OX=9913 GN=GRXCR1 PE=3 SV=1 CANONICAL=E1BCE8-1" }, "isoforms": [ { "isoform_ac": "E1BCE8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCE8/entry", "sequence": { "sequence": "MLKREVKPETDRPRKVRFRIASSHSGRVLREVYEDGRPAGSLDSECASICGLDGLSESDGQQNGHIGSEGDEQENDQDNLLVLARAASEKGFGTRRVNILSKNGTIRGVKYKVSAGQALFNNLTKVLQQPSTELEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDSFKALKCTACNENGLQRCKSCVG", "length": 290, "header": "tr|E1BCE8-1|E1BCE8_BOVIN Isoform 1 of Glutaredoxin domain-containing cysteine-rich protein 1 OS=Bos taurus OX=9913 GN=GRXCR1 PE=3 SV=1 CANONICAL=E1BCE8-1" }, "locus": { "chromosome": "6", "start_pos": 61829317, "end_pos": 61696746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046779.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046779.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044038.2", "url": "https://www.ensembl.org/id/ENSBTAP00000044038.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A8MXD5-1", "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 1", "gene_name": "GRXCR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLKREMKPESDRPRKVRFRIASSHSGRVLKEVYEDGQPSGSLDSECASICGIDGLGDSDGQQNGHIESEGDENENDQDSLLVLARAASEKGFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSTDLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGEYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDILTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSMFRNCFTDSFKALKCTACNENGLQRCKNCAG", "length": 290 }, "evidence": [ { "id": "E1BCE8", "url": "https://omabrowser.org/oma/group/E1BCE8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D4A048-1", "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 1", "gene_name": "Grxcr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRRETKPESDRPRKVRFRIASSHSGRVLKEVYEDGQAPGSLDSECASVCAIDGLSDSEGHQNGHIGLEDNEQEKDQDNLLVLARTASEKAFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSADLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDAFKALKCTACNENGLQRCKNCAC", "length": 290 }, "evidence": [ { "id": "E1BCE8", "url": "https://omabrowser.org/oma/group/E1BCE8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S3T4-1", "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 1", "gene_name": "GRXCR1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLKRDIKPETDRPRKVRFRIASSHSGRVLKEVYDDGRPAGSLDSECASICGIDGLSESDGQQNGHIGSEGDEQENDQDNLLVLARAASEKGFSTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSTDLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDSFKALKCTACNENGLQRCQSCAG", "length": 290 }, "evidence": [ { "id": "E1BCE8", "url": "https://omabrowser.org/oma/group/E1BCE8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q50H32-1", "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 1", "gene_name": "Grxcr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRRETKPESDRPRKVRFRIASSHSGRVLKEVYEDGQAPGSLDSECASICAIDGLSDSEGQQNGHIGSEDNEQEKDQDNLLVLARTASEKAFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSADLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGDYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDLLTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSVFRNCFTDAFKALKCTACNENGLQRCKNCTC", "length": 290 }, "evidence": [ { "id": "E1BCE8", "url": "https://omabrowser.org/oma/group/E1BCE8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "vestibular receptor cell development", "id": "GO:0060118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060118", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "pmid": "" }, { "name": "inner ear receptor cell stereocilium organization", "id": "GO:0060122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060122", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "pmid": "" }, { "name": "kinocilium", "id": "GO:0060091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060091", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "E1BCE8", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCE8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCE8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCE8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCE8" }, { "id": "PF00462", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glutaredoxin", "eco_id": "ECO_0000259", "start_pos": 139, "end_pos": 207, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 122, "end_pos": 124 }, { "start_pos": 218, "end_pos": 220 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCI3-1", "uniprot_ac": "E1BCI3", "uniprot_id": "E1BCI3_BOVIN", "mass": { "chemical_mass": 70126.0, "monoisotopic_mass": 70126.0 }, "refseq": { "ac": "XP_059731884", "name": "cationic amino acid transporter 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731884" }, "gene_names": [ { "name": "SLC7A4", "type": "recommended", "evidence": [ { "id": "E1BCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI3" } ] }, { "name": "SLC7A4", "type": "synonym", "evidence": [ { "id": "XP_059731884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731884" } ] } ], "protein_names": [ { "name": "Solute carrier family 7 member 4", "type": "synonym", "evidence": [ { "id": "E1BCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI3/entry#names_and_taxonomy" } ] }, { "name": "cationic amino acid transporter 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731884" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCI3", "url": "https://www.uniprot.org/uniprotkb/E1BCI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC7A4", "url": "https://www.uniprot.org/uniprotkb/E1BCI3", "locus": { "chromosome": "17", "start_pos": 72373077, "end_pos": 72376830, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009145", "url": "https://www.ensembl.org/id/ENSBTAG00000009145" } ] } } ], "crossref": [ { "id": "E1BCI3", "url": "https://alphafold.ebi.ac.uk/entry/E1BCI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009145", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009145", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504923", "url": "https://www.ncbi.nlm.nih.gov/gene/504923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCI3", "url": "https://www.orthodb.org/?gene=E1BCI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731884", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731884", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCI3", "url": "https://www.uniprot.org/uniprotkb/E1BCI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCI3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRPWSQGEQGACSWLRAPLCASLPTMAPGRPCAAGLARFCQKLKRRKLLADSSMATSLQRCLSALDLTLLGVGSMVGSGLYVLTGVVAKEVTGPAVTVSFVVAAVASLMAALCYAEFGARVPRTGSAYLFTYVSIGELWAFLIGWNLVLEYVIASAAVARAWSGYLDAMFDHRIQNFTEAHLGVWQVPFLARSPDWLAAGIILLASAFVSCGARVSSWLNHTLSAVSMIVILFIVVLGFILARPSNWGEAEGGFAPFGFSGVMSGTATCFYAFVGFDVIAASSEEARDPKRAVPLAIALSLGLAATAYILVSAVLTLMIPWHSLNPNSALADAFYQRGYSWAGYLVATGSICAMTTVQLSGLFCLPRIIYAMAADGLFFEMFAYVHPRTQVPLLGILAFGALTAVVTLLLDLDALVQFLSIGTLLAYTFVAISVLVLRFQTASQSRSPSLAGSGPKAKEYSSFSDHLELVGAGHGPEPGRLRPALRPYLGFLDRGSPGAAVRGAVCGLVVSAIALGCVLMLGHSVLRLPLWGFLLLLLCSSVTFLLSLLVLGAHQQQRLKDTFQMPLVPLIPALSIVLNFCLMLKLSYLTWVRFTIWLLIGLLVYFGYGIWHSKENWREPPGLVTARYVAFSDGRVEETVRDPGQAPAQGPGSP", "length": 655, "header": "tr|E1BCI3-1|E1BCI3_BOVIN Isoform 1 of Solute carrier family 7 member 4 OS=Bos taurus OX=9913 GN=SLC7A4 PE=4 SV=2 CANONICAL=E1BCI3-1" }, "isoforms": [ { "isoform_ac": "E1BCI3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI3/entry", "sequence": { "sequence": "MGRPWSQGEQGACSWLRAPLCASLPTMAPGRPCAAGLARFCQKLKRRKLLADSSMATSLQRCLSALDLTLLGVGSMVGSGLYVLTGVVAKEVTGPAVTVSFVVAAVASLMAALCYAEFGARVPRTGSAYLFTYVSIGELWAFLIGWNLVLEYVIASAAVARAWSGYLDAMFDHRIQNFTEAHLGVWQVPFLARSPDWLAAGIILLASAFVSCGARVSSWLNHTLSAVSMIVILFIVVLGFILARPSNWGEAEGGFAPFGFSGVMSGTATCFYAFVGFDVIAASSEEARDPKRAVPLAIALSLGLAATAYILVSAVLTLMIPWHSLNPNSALADAFYQRGYSWAGYLVATGSICAMTTVQLSGLFCLPRIIYAMAADGLFFEMFAYVHPRTQVPLLGILAFGALTAVVTLLLDLDALVQFLSIGTLLAYTFVAISVLVLRFQTASQSRSPSLAGSGPKAKEYSSFSDHLELVGAGHGPEPGRLRPALRPYLGFLDRGSPGAAVRGAVCGLVVSAIALGCVLMLGHSVLRLPLWGFLLLLLCSSVTFLLSLLVLGAHQQQRLKDTFQMPLVPLIPALSIVLNFCLMLKLSYLTWVRFTIWLLIGLLVYFGYGIWHSKENWREPPGLVTARYVAFSDGRVEETVRDPGQAPAQGPGSP", "length": 655, "header": "tr|E1BCI3-1|E1BCI3_BOVIN Isoform 1 of Solute carrier family 7 member 4 OS=Bos taurus OX=9913 GN=SLC7A4 PE=4 SV=2 CANONICAL=E1BCI3-1" }, "locus": { "chromosome": "17", "start_pos": 72376631, "end_pos": 72373308, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012050.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012050.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012050.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012050.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 98, "start_aa": "Thr", "end_pos": 98, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr98", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCI3", "url": "https://www.uniprot.org/uniprotkb/E1BCI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "E1BCI3", "url": "https://www.uniprot.org/uniprotkb/E1BCI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "amino acid transmembrane transporter activity", "id": "GO:0015171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015171", "evidence": [ { "database": "UniProtKB", "id": "E1BCI3", "url": "https://www.uniprot.org/uniprotkb/E1BCI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 655, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCI3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI3" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 564, "end_pos": 614, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 98 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 221, "end_pos": 223 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCM3-1", "uniprot_ac": "E1BCM3", "uniprot_id": "E1BCM3_BOVIN", "mass": { "chemical_mass": 43741.0, "monoisotopic_mass": 43741.0 }, "refseq": {}, "gene_names": [ { "name": "RNF215", "type": "recommended", "evidence": [ { "id": "E1BCM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ] } ], "protein_names": [ { "name": "RING finger protein 215", "type": "recommended", "evidence": [ { "id": "E1BCM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCM3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF215", "url": "https://www.uniprot.org/uniprotkb/E1BCM3", "locus": { "chromosome": "17", "start_pos": 69375109, "end_pos": 69382688, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003394", "url": "https://www.ensembl.org/id/ENSBTAG00000003394" } ] } } ], "crossref": [ { "id": "E1BCM3", "url": "https://alphafold.ebi.ac.uk/entry/E1BCM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003394", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003394", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16670", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16670", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCM3", "url": "https://www.orthodb.org/?gene=E1BCM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPAARPALRSPPPPPPPPPPPPSPLLLLLPLLPLWLGLAGPGAAADGGEPAAGAGRGGARAVRVDVRLPRQDALVLQGVRIGPEADPAPPLGGRLLLMDIVDAEQDAPVEGWIAVAYVGKEQEAQIHQESQGAGPQAYPKALVQQMRRALFLGASALLLLVLNHNVVRELDISQLLLRPVIVLHYSSNVTKLLEALLQLGQVGLSLSSQEPFRLAPLASPPRRTQATAEITSGESLSANIEWKLTLWTTCGLSKDGYGGWQDLVCLGGSRAQEQKPLQQLWNAILLVAMLLGTGLVVQAQRQASRQSRREPGGQVELLKRRVVQRLASLKTRRCRLGRAAQSPPEPGAETCAVCLDYFCNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGNRYSDD", "length": 404, "header": "tr|E1BCM3-1|E1BCM3_BOVIN Isoform 1 of RING finger protein 215 OS=Bos taurus OX=9913 GN=RNF215 PE=4 SV=4 CANONICAL=E1BCM3-1" }, "isoforms": [ { "isoform_ac": "E1BCM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCM3/entry", "sequence": { "sequence": "MGPAARPALRSPPPPPPPPPPPPSPLLLLLPLLPLWLGLAGPGAAADGGEPAAGAGRGGARAVRVDVRLPRQDALVLQGVRIGPEADPAPPLGGRLLLMDIVDAEQDAPVEGWIAVAYVGKEQEAQIHQESQGAGPQAYPKALVQQMRRALFLGASALLLLVLNHNVVRELDISQLLLRPVIVLHYSSNVTKLLEALLQLGQVGLSLSSQEPFRLAPLASPPRRTQATAEITSGESLSANIEWKLTLWTTCGLSKDGYGGWQDLVCLGGSRAQEQKPLQQLWNAILLVAMLLGTGLVVQAQRQASRQSRREPGGQVELLKRRVVQRLASLKTRRCRLGRAAQSPPEPGAETCAVCLDYFCNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGNRYSDD", "length": 404, "header": "tr|E1BCM3-1|E1BCM3_BOVIN Isoform 1 of RING finger protein 215 OS=Bos taurus OX=9913 GN=RNF215 PE=4 SV=4 CANONICAL=E1BCM3-1" }, "locus": { "chromosome": "17", "start_pos": 69382569, "end_pos": 69379315, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004400.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004400.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004400.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004400.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "frizzled binding", "id": "GO:0005109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005109", "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "pmid": "" }, { "name": "Wnt receptor catabolic process", "id": "GO:0038018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038018", "evidence": [ { "database": "UniProtKB", "id": "E1BCM3", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 404, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCM3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCM3" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 352, "end_pos": 393, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCM8-1", "uniprot_ac": "E1BCM8", "uniprot_id": "E1BCM8_BOVIN", "mass": { "chemical_mass": 40866.0, "monoisotopic_mass": 40866.0 }, "refseq": { "ac": "XP_010799324", "name": "G-protein coupled receptor 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799324" }, "gene_names": [ { "name": "GPR15", "type": "recommended", "evidence": [ { "id": "E1BCM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ] }, { "name": "GPR15", "type": "synonym", "evidence": [ { "id": "XP_010799324", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799324" } ] } ], "protein_names": [ { "name": "G-protein coupled receptor 15", "type": "recommended", "evidence": [ { "id": "E1BCM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCM8/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 15", "type": "synonym", "evidence": [ { "id": "XP_010799324", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799324" } ] } ], "function": [ { "annotation": "G protein-coupled receptor that plays an important role in immune homeostasis. Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells. Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria. Also required for skin localization of thymus-derived dendritic epidermal T-cells. Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin. Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores.", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8#function" }, { "database": "UniProtKB", "id": "ARBA00093298", "url": "https://www.uniprot.org/uniprotkb/ARBA00093298#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR15", "url": "https://www.uniprot.org/uniprotkb/E1BCM8", "locus": { "chromosome": "1", "start_pos": 42844680, "end_pos": 42839200, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020997", "url": "https://www.ensembl.org/id/ENSBTAG00000020997" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020997", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020997", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538740", "url": "https://www.ncbi.nlm.nih.gov/gene/538740", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538740", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538740", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BCM8", "url": "https://www.orthodb.org/?gene=E1BCM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10489:SF954", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10489:SF954", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010799324", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799324", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPVMDPEATTVYLEYLFVTSHNPDIEETHSHVPYTSVFLPVFYTAVFLIGVSGNLILMSALHFKRGSRRLIDIFIINLAASDFIFVITLPLWVDKEASLGLWRTGSFLCKGSSYVISVNMHCNVFLLTCMSVDRYLAIVCPAVSRKVRRRDCAYAVCASVWFVSCLLGLPTLLSRELTLIDGKPYCAEERATPVKLTWALVALIFTFFAPLVSIVSCYCCITRKLCVHYQQSGKHNKKLRKSMKIIFIVVAAFVLSWLPFNTFKLLAIVSGLQQELYLSSAFLQRGMEVCGPLAFANSCVNPFIYYIFDGYIRRAIVRCLCPCLKNYDFGSSTETSDLTKALSNFIHAEDFARKRKRSVSL", "length": 362, "header": "tr|E1BCM8-1|E1BCM8_BOVIN Isoform 1 of G-protein coupled receptor 15 OS=Bos taurus OX=9913 GN=GPR15 PE=3 SV=3 CANONICAL=E1BCM8-1" }, "isoforms": [ { "isoform_ac": "E1BCM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCM8/entry", "sequence": { "sequence": "MDPVMDPEATTVYLEYLFVTSHNPDIEETHSHVPYTSVFLPVFYTAVFLIGVSGNLILMSALHFKRGSRRLIDIFIINLAASDFIFVITLPLWVDKEASLGLWRTGSFLCKGSSYVISVNMHCNVFLLTCMSVDRYLAIVCPAVSRKVRRRDCAYAVCASVWFVSCLLGLPTLLSRELTLIDGKPYCAEERATPVKLTWALVALIFTFFAPLVSIVSCYCCITRKLCVHYQQSGKHNKKLRKSMKIIFIVVAAFVLSWLPFNTFKLLAIVSGLQQELYLSSAFLQRGMEVCGPLAFANSCVNPFIYYIFDGYIRRAIVRCLCPCLKNYDFGSSTETSDLTKALSNFIHAEDFARKRKRSVSL", "length": 362, "header": "tr|E1BCM8-1|E1BCM8_BOVIN Isoform 1 of G-protein coupled receptor 15 OS=Bos taurus OX=9913 GN=GPR15 PE=3 SV=3 CANONICAL=E1BCM8-1" }, "locus": { "chromosome": "1", "start_pos": 42844680, "end_pos": 42844128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027963.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027963.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027963.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027963.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538740", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538740", "resource": "KEGG Pathway" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" }, { "name": "T cell migration", "id": "GO:0072678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072678", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" }, { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" }, { "name": "virus receptor activity", "id": "GO:0001618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001618", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCM8", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCM8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 306, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCP5-1", "uniprot_ac": "E1BCP5", "uniprot_id": "E1BCP5_BOVIN", "mass": { "chemical_mass": 43602.0, "monoisotopic_mass": 43602.0 }, "refseq": { "ac": "XP_024836420", "name": "protein Njmu-R1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836420" }, "gene_names": [ { "name": "C19H17orf75", "type": "recommended", "evidence": [ { "id": "E1BCP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ] }, { "name": "C19H17orf75", "type": "synonym", "evidence": [ { "id": "XP_024836420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836420" } ] } ], "protein_names": [ { "name": "Chromosome 19 C17orf75 homolog", "type": "synonym", "evidence": [ { "id": "E1BCP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP5/entry#names_and_taxonomy" } ] }, { "name": "protein Njmu-R1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024836420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836420" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C19H17orf75", "url": "https://www.uniprot.org/uniprotkb/E1BCP5", "locus": { "chromosome": "19", "start_pos": 17817384, "end_pos": 17802633, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020994", "url": "https://www.ensembl.org/id/ENSBTAG00000020994" } ] } } ], "crossref": [ { "id": "E1BCP5", "url": "https://alphafold.ebi.ac.uk/entry/E1BCP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506032", "url": "https://www.ncbi.nlm.nih.gov/gene/506032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506032", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506032", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FEDAICP", "url": "https://omabrowser.org/oma/group/FEDAICP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCP5", "url": "https://www.orthodb.org/?gene=E1BCP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14416:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14416:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836420", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836420", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPSLQESLDGDEKELESSEEGGSAEEPSSHYCLYSYRGSRLAQQRADSDDGSPGGTNAESPSGDDFSLSLVDTNLPSEVEPELRSFIAKRLSKGAVFEGLGNVAAVELRIPGYRVGCYYCLFQQEKLLPQTASTDSEQKSSEYVVCFLGGSEKGLELFRLELDKYIQGLKNNMNCEESGGENHIQSYLSSWFADVVCPIQRVVHLFQEKLTFLLHAALSYTPVEVKGSDEKTKRDIHRFLSVASLQGLIHEGTMTSLCMAMTEEQQKSVIIDCSSSQPQFHNAGSNRFCEDWMQAFMNGAEGGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKNVVAVLEEFMKEAAAQSF", "length": 390, "header": "tr|E1BCP5-1|E1BCP5_BOVIN Isoform 1 of Chromosome 19 C17orf75 homolog OS=Bos taurus OX=9913 GN=C19H17orf75 PE=4 SV=3 CANONICAL=E1BCP5-1" }, "isoforms": [ { "isoform_ac": "E1BCP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP5/entry", "sequence": { "sequence": "MLPSLQESLDGDEKELESSEEGGSAEEPSSHYCLYSYRGSRLAQQRADSDDGSPGGTNAESPSGDDFSLSLVDTNLPSEVEPELRSFIAKRLSKGAVFEGLGNVAAVELRIPGYRVGCYYCLFQQEKLLPQTASTDSEQKSSEYVVCFLGGSEKGLELFRLELDKYIQGLKNNMNCEESGGENHIQSYLSSWFADVVCPIQRVVHLFQEKLTFLLHAALSYTPVEVKGSDEKTKRDIHRFLSVASLQGLIHEGTMTSLCMAMTEEQQKSVIIDCSSSQPQFHNAGSNRFCEDWMQAFMNGAEGGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKNVVAVLEEFMKEAAAQSF", "length": 390, "header": "tr|E1BCP5-1|E1BCP5_BOVIN Isoform 1 of Chromosome 19 C17orf75 homolog OS=Bos taurus OX=9913 GN=C19H17orf75 PE=4 SV=3 CANONICAL=E1BCP5-1" }, "locus": { "chromosome": "19", "start_pos": 17816380, "end_pos": 17806067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027955.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027955.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027955.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027955.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506032", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506032", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZEJ9-1", "protein_name": "Similar to human chromosome 17 open reading frame 75", "gene_name": "C10h17orf75", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGRREFGVLDIKAELLDIAVLQPRWVSPAQGRELWAAAGDGWRNPGLSVMLRQAPGSETGPGAEFPGPGLGKLRNSDVRGPGGGRTGAQRTARRRGNGLTGTQGREEAAAMLPSLQESLDGDEKELESSEEGGSAEERRLEPPPSSHYCLYSFRGSRLTQNRGDSDDGRSCGTNAETPSGDDFSLSLVDSNLPSEVEPELRSFIAKRLSKGAFFEGLGNVASVELRIPGYRVGCYYCLFQQEKLLPEIAAVESEHNPSEYVVCFLGGSEKGLELFRLELDKYIQGLKSNMNCEERSLGSDLKSYLNSWYEDVLCPIQRVVLLFQEKLTFLLHAALSYTPVEFKESDEKTKRDINRFLSVASLQGLIHEGTMTSLCMAMTEEQHKSVIIDCSGPQPQFHNAGSNRFCEDWMQAFLHSAEGGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYLFLKNCGSGDILLKIVKVEHEEMPEAKSVVAVLEEFMREALV", "length": 504 }, "evidence": [ { "id": "E1BCP5", "url": "https://omabrowser.org/oma/group/E1BCP5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CYI0-1", "protein_name": "Protein Njmu-R1", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPSLQESLDGDEKELESSEEGGSAEERRLEPPPSSHYCLYSFRGSRLTQNRGDSDDGRSGGINAETPSGDDFSLSLVDTNLPSEVEPELRSFIAKRLSKGAVFEGLGNVASVELRIPGYRVGCYYCLFQQEKLLPEIAAMESEHNPSEYVVCFLGGSEKGLELFRLELDKYIQGLKNNMNCEERSLGNDVKSYLNSWYEDVVCPIQRVVLLFQEKLTFLLHAALSYTPVEFKESDEKTKRDINRFLSVASLQGLIHEGTMTSLCMAMTEEQHKSVIIDCSGPQPQFHNAGSNRFCEDWMQAFLHGAEAGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKSVVAVLEEFMREALV", "length": 393 }, "evidence": [ { "id": "E1BCP5", "url": "https://omabrowser.org/oma/group/E1BCP5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HAS0-1", "protein_name": "Protein Njmu-R1", "gene_name": "C17orf75", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPSLQESMDGDEKELESSEEGGSAEERRLEPPSSSHYCLYSYRGSRLAQQRGDSEDGSPSGTNAETPSGDDFSLSLADTNLPSEVEPELRSFIAKRLSRGAVFEGLGNVASVELKIPGYRVGCYYCLFQNEKLLPETVTIDSERNPSEYVVCFLGGSEKGLELFRLELDKYIQGLKNNMNCEARGLESHIKSYLSSWFEDVVCPIQRVVLLFQEKLTFLLHAALSYTPVEVKESDEKTKRDINRFLSVASLQGLIHEGTMTSLCMAMTEEQHKSVVIDCSSSQPQFCNAGSNRFCEDWMQAFLNGAKGGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKNVIAVLEEFMKEALDQSF", "length": 396 }, "evidence": [ { "id": "E1BCP5", "url": "https://omabrowser.org/oma/group/E1BCP5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ], "pmid": "" }, { "name": "vesicle tethering to Golgi", "id": "GO:0099041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099041", "evidence": [ { "database": "UniProtKB", "id": "E1BCP5", "url": "https://www.uniprot.org/uniprotkb/E1BCP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCP5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 390, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCP5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCP5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCR2-1", "uniprot_ac": "E1BCR2", "uniprot_id": "E1BCR2_BOVIN", "mass": { "chemical_mass": 237831.0, "monoisotopic_mass": 237831.0 }, "refseq": { "ac": "XP_015329728", "name": "death-inducer obliterator 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329728" }, "gene_names": [ { "name": "DIDO1", "type": "recommended", "evidence": [ { "id": "E1BCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ] }, { "name": "DIDO1", "type": "synonym", "evidence": [ { "id": "XP_015329728", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329728" } ] } ], "protein_names": [ { "name": "Death-inducer obliterator 1", "type": "recommended", "evidence": [ { "id": "E1BCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR2/entry#names_and_taxonomy" } ] }, { "name": "Death-associated transcription factor 1", "type": "synonym", "evidence": [ { "id": "E1BCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR2/entry#names_and_taxonomy" } ] }, { "name": "death-inducer obliterator 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015329728", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329728" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIDO1", "url": "https://www.uniprot.org/uniprotkb/E1BCR2", "locus": { "chromosome": "13", "start_pos": 54521457, "end_pos": 54471009, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006002", "url": "https://www.ensembl.org/id/ENSBTAG00000006002" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006002", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006002", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15639", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15639", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519826", "url": "https://www.ncbi.nlm.nih.gov/gene/519826", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012921", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012921", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HPNQFDG", "url": "https://omabrowser.org/oma/group/HPNQFDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11477", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11477", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11477:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11477:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07500", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07500", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07744", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07744", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015329728", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329728", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCR2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDDKGDPSGEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEVDTLEPSPRQQQSPSLRRSGRQPKRTERVEEFLTTVRRRGRRSAPVSLEDSGEPASCPATDAETASEGSVESASDGKSGPRSSSTGAKQRLASSAKAREGEDEDDTSDSDSDGLTLKELQNRLRKKREQEPADRPTRGIQNRLRRKRREEDPAETVDVQAGDVMEGSLPASREPEGDLGAAAQAVKEDREGRQDGRVAPGGRAEEAADSIRHKPECEVYDPSALYCLCRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDEASSEATDMQDTRSGPLGADSTDFTSIGTVEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAAKCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSAGKEQKPKAKEKLKTKPEKIVLQKCSVQAGIKISSVHKRLASDKKENAVKKAAVAPPRNEVLTKEPVCESSTPSWASDHNYNAVKPEQTAAPWPPLLYKSVKEDRRMEDKMAVVVAKKLAPPGSSGAGRQPPGRNLLPKKSPSFANTAVAKPTVRKSPSGFKGTIPKRPWLSSTTSPSGSAPSAKQAGLVTAAATSASRKFPSSTASVGAVRKPGSTSVPLASPAPGRLGPVSPASSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALLIEKEMFNLFRVTDNRYKSKYRSLMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSVWRERTTKPVMESRTKLHNETKKPAIKQEAVPDMEDSPPVSDSDEQQESVRAAPERSAAPLPGVFSSMLQDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASVKKEESKSKRDSPPPDPVLSEADDAAPETPPENASEPDLESAAHTHLEGKYLPVPLEDNQPEPPALEGLPCPTPGGGSVLTMVTMSGRDPRTALGGPSTATASAATHLEGTTPAEPRQDVPKPVPPSVTVPKSILAKPSASPEPRYLLSVPPSPSISISESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYIGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRDRFGVVANNSRHVKDLYLIPLSATDPIPSKLLPFEGPGLESPRPNIILGLVICQKTKRPSGAGELDKTEEKRARLLTQDEVEPVHPKVPAALPPEKRPTKYQLCPGDAAVSTTPPGSPPPPPPPPEAPGAPGSSSMLKILSTLKPGATAPSGTAAAAPAAASSVSSTSKTASPLEHILQTLFGKKKSFDPLSKEPVESAPAPHQDSKAKTDGGLTAAPLLDPIVQQFGQISKDRALEEEEDDRPYDPEEEYGPERALDTPPSDRTRHQDAEEAPEAAEREEVAYDPEDETILEEAKVTIDDLPNRMCVDTRGGPGLSAPSLVEQQKMIEELNKQIEEQKRQVEEQEEALRQQRAAVGASMAHFSVSDALMSPPPKATLPKAELFPQEPQAAVKPAPAPATNQAPGPNAEARLSRDPRQARRLAVENNESEAALRAPPAREAPGGVSAGPGLLPAQEEPESAPPPWTPGEEAPLPAKQDGPPHEPSETLGPESMAGLDAVARPARKVLLPTPPGASFQPLYPPQSEGQAFPPPGFSGPMYAPQENPMGSSQYDDPRNAQFAEKSDALATDTEGDREPQPRPGEGAGVFPALAQKGGPPPQFQGQREPTPRAFGMSGLHGPSFPAPRGPVPPFSEENTNNDGPRGGPPPARFGPPKGPIPSLFSGPHGPPPYGDGRGPSPSHLGGPRGAGPPLLEERKDAHGEKREYPDALYGEASGGPAQCEGPEQAPFPGGRGATPFQFGGQRRPLLSQFKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPGQFEGPRGQAPGFVPGPRGMQPQQFEEQRVHSPPRFSGQRAPAPLPFGGPRGGAPFPEKSEPVPPRFHFQGPAPPGPKPAPRPLLELPSHPPAPSAAPAQGPEADFREGGRGHEYRGPAFEGRPRDKAPEDPEAPPPDSRSGRALDDRRRERERGKPWERERGRTWSRERDWDRGRDWDRHRDKDAGRDWDRSRERNGSRDKGREWDRGRERSRNRDRDRRRDRERSRSRDRDRDKARERERRRDRSRSPERPRDPKTETPRAAAPTAQT", "length": 2196, "header": "tr|E1BCR2-1|E1BCR2_BOVIN Isoform 1 of Death-inducer obliterator 1 OS=Bos taurus OX=9913 GN=DIDO1 PE=4 SV=3 CANONICAL=E1BCR2-1" }, "isoforms": [ { "isoform_ac": "E1BCR2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR2/entry", "sequence": { "sequence": "MDDKGDPSGEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEVDTLEPSPRQQQSPSLRRSGRQPKRTERVEEFLTTVRRRGRRSAPVSLEDSGEPASCPATDAETASEGSVESASDGKSGPRSSSTGAKQRLASSAKAREGEDEDDTSDSDSDGLTLKELQNRLRKKREQEPADRPTRGIQNRLRRKRREEDPAETVDVQAGDVMEGSLPASREPEGDLGAAAQAVKEDREGRQDGRVAPGGRAEEAADSIRHKPECEVYDPSALYCLCRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDEASSEATDMQDTRSGPLGADSTDFTSIGTVEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAAKCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSAGKEQKPKAKEKLKTKPEKIVLQKCSVQAGIKISSVHKRLASDKKENAVKKAAVAPPRNEVLTKEPVCESSTPSWASDHNYNAVKPEQTAAPWPPLLYKSVKEDRRMEDKMAVVVAKKLAPPGSSGAGRQPPGRNLLPKKSPSFANTAVAKPTVRKSPSGFKGTIPKRPWLSSTTSPSGSAPSAKQAGLVTAAATSASRKFPSSTASVGAVRKPGSTSVPLASPAPGRLGPVSPASSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALLIEKEMFNLFRVTDNRYKSKYRSLMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSVWRERTTKPVMESRTKLHNETKKPAIKQEAVPDMEDSPPVSDSDEQQESVRAAPERSAAPLPGVFSSMLQDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASVKKEESKSKRDSPPPDPVLSEADDAAPETPPENASEPDLESAAHTHLEGKYLPVPLEDNQPEPPALEGLPCPTPGGGSVLTMVTMSGRDPRTALGGPSTATASAATHLEGTTPAEPRQDVPKPVPPSVTVPKSILAKPSASPEPRYLLSVPPSPSISISESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYIGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRDRFGVVANNSRHVKDLYLIPLSATDPIPSKLLPFEGPGLESPRPNIILGLVICQKTKRPSGAGELDKTEEKRARLLTQDEVEPVHPKVPAALPPEKRPTKYQLCPGDAAVSTTPPGSPPPPPPPPEAPGAPGSSSMLKILSTLKPGATAPSGTAAAAPAAASSVSSTSKTASPLEHILQTLFGKKKSFDPLSKEPVESAPAPHQDSKAKTDGGLTAAPLLDPIVQQFGQISKDRALEEEEDDRPYDPEEEYGPERALDTPPSDRTRHQDAEEAPEAAEREEVAYDPEDETILEEAKVTIDDLPNRMCVDTRGGPGLSAPSLVEQQKMIEELNKQIEEQKRQVEEQEEALRQQRAAVGASMAHFSVSDALMSPPPKATLPKAELFPQEPQAAVKPAPAPATNQAPGPNAEARLSRDPRQARRLAVENNESEAALRAPPAREAPGGVSAGPGLLPAQEEPESAPPPWTPGEEAPLPAKQDGPPHEPSETLGPESMAGLDAVARPARKVLLPTPPGASFQPLYPPQSEGQAFPPPGFSGPMYAPQENPMGSSQYDDPRNAQFAEKSDALATDTEGDREPQPRPGEGAGVFPALAQKGGPPPQFQGQREPTPRAFGMSGLHGPSFPAPRGPVPPFSEENTNNDGPRGGPPPARFGPPKGPIPSLFSGPHGPPPYGDGRGPSPSHLGGPRGAGPPLLEERKDAHGEKREYPDALYGEASGGPAQCEGPEQAPFPGGRGATPFQFGGQRRPLLSQFKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPGQFEGPRGQAPGFVPGPRGMQPQQFEEQRVHSPPRFSGQRAPAPLPFGGPRGGAPFPEKSEPVPPRFHFQGPAPPGPKPAPRPLLELPSHPPAPSAAPAQGPEADFREGGRGHEYRGPAFEGRPRDKAPEDPEAPPPDSRSGRALDDRRRERERGKPWERERGRTWSRERDWDRGRDWDRHRDKDAGRDWDRSRERNGSRDKGREWDRGRERSRNRDRDRRRDRERSRSRDRDRDKARERERRRDRSRSPERPRDPKTETPRAAAPTAQT", "length": 2196, "header": "tr|E1BCR2-1|E1BCR2_BOVIN Isoform 1 of Death-inducer obliterator 1 OS=Bos taurus OX=9913 GN=DIDO1 PE=4 SV=3 CANONICAL=E1BCR2-1" }, "locus": { "chromosome": "13", "start_pos": 54520453, "end_pos": 54492096, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007879.8", "url": "https://www.ensembl.org/id/ENSBTAT00000007879.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007879.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007879.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1611, "start_aa": "Thr", "end_pos": 1611, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1611", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 952, "start_aa": "Thr", "end_pos": 952, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr952", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZXE0-1", "protein_name": "Death-inducer obliterator 1", "gene_name": "Dido1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDDKGDLSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDTEVDPSEQQPQQHNLSLRRSGRQPKRTERVEEFLTTVRRRGRKNVPVSLEDSSEPTSSTVTDVETASEGSVESSSEIRSGPAPGTLGKEHPSSSEKVKGGDEEEDTSDSDSDGLTLKELQNRLRRKREQEPVERSLRGIQNRLRKQRREEDPAEAGSVQIGSIEEDTPRCKQEPEASQGPVSQSEKDDRENQLEGKATQGSKEESPREAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETSSSAADEQDAGCRPVGADGTDCTSIGTVEQRSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAAKCIGPGCSNVAQPDSVYCSNDCILKHAAATMKILSSGKEQKPKPKEKVKMKPEKFSLPKCSVQAGIKISSVHKRLASEKRENPVKKVTLASRSETSVKEATCESTPSWASDHNYNAVKPEKPEKPEKPTALSPTLLSKSMKDDKRVEDRTVAAAAVPKKAVPPGSVMGRQTSPRNLVPKKLPPYPNMAGAKTAVKKLPSGFKGTIPKRPWPSATLSGTSARQAGPTPVIAASKKLPGSAAVVGIARKPMSANVPAASPVPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKKNSTKPETIPDMEDSPPVSDSEEQESVRAAPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKKEDLKARHDSSPPDAVPSTADEGIAETPENTCDPDLETVSSLNQERKGFPESAGDSHPEPSSLDGLSSSFASGGSGVVTTVTVSGRDPRTALSGSCTVTASMAAHMDNSQTSETKLEILKPALTSAVVPKSILAKPSSSPDPRYLSVPPSPNTSISESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGELDKTDEKRPRLQQEETETSVYPKVTAALPSEKKPPKYSVHSADTTASSTTPPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTAPTTSAVITTTASPVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLAPHHDSKAKGEDTMSAAPLLDPIVQQFGQFSKDKALEEEEEDDRPYDPEEEYNPDRAFHTLLAEPGRPHDVPSVPETAEREEVAYDPEDETILEEAKVTIDDLPNRMCVKVSSTERPADFSTDASSASLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQALDPSQGSLSTNHSLDSRQSRDPRQARRLAAENTENESLPRAPTGSTSGPQGTLPARETPAGAAVAQGPGLAAEAKESMASPWAPGENTVLRPEHDIQKCEHSSNPVSLPLDTSHLPTAGDGTARPAPPRRVLLPTPPSTTFPPSFPLQPEAQNFSSGGREPFSGPTFLSQETSLGSSQYEDPRGAQSAGRSDSPVADMEDSREPQPRPGEGATSFPSPAQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPFSEENIVPNSDGSRGPPPPRFGAQKPPIPSLFSGQHGPPPYGDNRGLSPSYLGGPRGGAPAQFEDRKDPHGEKREFQDTPYEMTGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLLTQIKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPSQFETSRGTHPGQFEGARGQAPGFMPGPRGVQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQPPSRFHFQGPSSQPVKPPPRPLLELPSHPPQHRKDRWDEAGTATALPPSSGPGQGHEADGQWATSEFREGKGHEYRSPAFEGRQRERFEAGPKEKPLDEPEAQGLESRQGRAFEDRRRERERGRNWSREKDWERSRDWDRHREWDKGRDRSSNRDRERDTDRGKEWDRSRERSRNRDRDRERRRDRDRSRSRDRDRDRERARDRDRDRGRDRKDRSKSRESPRDLKPEARTSEGGPAAAQA", "length": 2258 }, "evidence": [ { "id": "E1BCR2", "url": "https://omabrowser.org/oma/group/E1BCR2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZVZ7-1", "protein_name": "Death-inducer obliterator 1", "gene_name": "DIDO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCDELEILNREIERLLQSSSVEGSTLSNSDCLQTSQTDSLDVITGSDSGAKYQLEQESSEKEFLVLAPADNSERRSGASGSRNSACAGRIMLNDSDPLLPSSGSPFNSAQQGETVQTSNAVSVFQGGESGVYTMEQAVSLQPVSMESESNTDNMENSSPASALDEKGEQSNEEEQKSIKPTSKEFRKTWGFRRTTIAKREGAGDIDMDSSEQQPQQQQQSLNLRRSGRQPKRTERVEEFLTTVRRRGRRNAPIALEDSSEPASCPATDAETASEDSVESASDIKSGTRRTGTRNSKDQKGSKNRRTKEEEEEEDEEEEEEEDTSDSDSDGLTLKELQNRLRNKRVEQKPTQLTLKEMQNRLRKRTSEQDPAETDNVQSDQPVKTELSVKQEPDIVDNTEIASQVVVSEENTEDLQVQKEIKPAAGAKGIADEEPEELPKSKPESEIYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQGQDESISETDQQEAKAGQVNVDGTEFTSIGTIEHKSVEDQGIKGRIEKAANPSGKKKLKIFQPVVDAPGVSKCIGPGCFNVAQPDSVYCSNDCILKHAAATMKYLSTGKDTKPKPKEKTKPKSEKPGVTKSHLQASTKPLSNQKRQFPEKKETNVKKTVLSAAKTEANTQPIAREPAAENTTPSWASDHNYNAVKPEKTAAISSSLLFKSQKGEKKKEDKAAEHTVASKRAVASTSVAEKQTSSLTKNLLPKKAPTFSSLPLTKQPLKSSTGSFKGVIPKKPWPSSDSVPSKPSAPPGSSLPKKPVASSSLGAGLKRPAPSSVPTASGSSQVKVSAIPIQSQPNSQIRQNIRRSLKEILWKRVNDSDDLVMTESEVGKVALNIEKEMFNLFHVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLHGEISLSKLVRMKPEELLSKELSVWKEKPAKAVIESRKKSHEVKKVAVKREHAPDVNMEDSPPVSDSDEQQESARNVPKSNSAPSLDVFSSMLKDTTSQHRAHLFDLNCKICTGQISASEDEVPAKKSKTVASVKKVETKSKPEVQQKYESSAPPAAAEPAKEAVSEDAMETDVEPAAEVVSQSNIERSYIPTTQVQNDTDSSVPEEASALPAVCAGGVVTTVTVSGRDPRTALGSASAAAATAPRSGPASEKVSVGESKQETSKPVMTVPKSILTKPSSSPDPRYLAVHQLPSINVAEPRSPQDSDTSLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRISPKTVWDYVGKLKSSLSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSSKDPIPSKLLPFEGPGLESSRPNLILGLVICQKGKRPATGMETDKIEEKRSRIQLQEEAEPSQFLKGPTASFQEKKTPKYTLYSGDSAVSTTPPGSPPPPPPPLPVPESSAVTPSVLKILSSIKSGSTTTAPPPVSATASPSVTATHSSSSKTATPLEHILQTLFGKKKSFEPAAKESETAQSSNQKAQAAAEGGMAAVPLLDPIVQQFGQMSKDKAIEEEEDDRPYDPEEEYDPEKAFEMQTGESEKLYSVEKPSNTAVLEDEAYDPEDETILEEAKVTVDDLPNKMYTDAKSSATETPAPYVPDLSASSSLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLIKTELFQQGQQAVQKVDLPSSANQQAQVLNQGSDPRQTRDPRQARRMATEINDNNDARIKPQAVQSETPAREILPASFPSALSASLGKEDNTLMSAPQLSYTGDNWVSGEQACTVSQKEVSSSKFENTAQVNLENVNQTVPGEPSTSKPLRKVLLPTPPTTCFQPNFSTPNDSQSLQDMHQVSWPNEPKEAIGRDSFPNAMFTSQENAGGHYEPERGLSSLQYEEQRNPQPHQFVEQTESTSIQGEGGPLPQHFEENRLPFSLPGQKGGPPQPPIHNAPGGPHGPNFRGPAPQFSEEHGSPNSDGQRGPAPGRFGPQKGPIPSLFSSQHGSPLFGDNRGPAPSYGVPRGMSPSQFEDHMEPHMEQREFSDSQYNEMIRPPGQFEGSDQPQFMGNRGPFPFGGQRRPPPAQFKGQRGGPQFGGPRGPAPGHFGGPRGPHTNQFEGQRGPAPNHGPGPRGLLPQPFEERRGSPPPRFANQRGPAPPQYGGPRGPSPALFPEQNEPPSRFHFQGQSQQSMKSTPRPLLDLPGHLSAHRKEMWEEAGPSASLPNVSGQGHESEGQWSASDFRESKNIEYRGQTFEGRQRERYEGGNKDKGLDQPEPQQADNRQGRPFEERRRDREHGRPWERDRGRNWNRDRDWERHRDKEWDKNRDRNQNKDREKDSEHAKDWERSRDRDRARTRDRESYRRRDRERSRSRDRDRDRDKDRDRDRSREKERDRERDRDRERGKDRKDRSKTRETGKEVKPEAPKESQKPTETEASSSTSQS", "length": 2493 }, "evidence": [ { "id": "E1BCR2", "url": "https://omabrowser.org/oma/group/E1BCR2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7G446-1", "protein_name": "Death-inducer obliterator 1", "gene_name": "Dido1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDDKGHLSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDTEVDPSEQPPQQHSLSLRRSGRQPKRTERVEEFLTTVRRRGRKSVPVSLEDSSEPTSSTVTDVETASEGSVESSSEVRSGPAPGSSGNEHPASSEKAKGVDEEEDTSDSDSDGLTLKELQNRLRRKREQEPSERPLRGIQNRLRKKRREEDPAETGSVLTGSADESVPLCKPEPEASQGPVSQSEKDDRENQSEGKATQGSKEEGPRDAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETSASAADEQDTGCRPLGADGTDCTSIGVVEQKSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAAKCIGPGCSNVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKPKPKEKVKMKPEKFSLPKCSVQAGIKISSVHKRLASEKKENPVKKVMVAPRSETCGKEVTCESTTPSWASDHNYNAVKPEKPEKPEKPTALSPTLLSKSMKEDRRAEDRTVAVAAVPKKTIPPGSLMGRQTSPRNLAPKKLPPYASMAGAKPAIKKLPSGFKGTIPKRPWPSATPSGTSARQAGPTPVTAASKKLPGSAAVVGVIRKPMSANASAASPAPGRLGPVSSAPSQPNSQIRQNIRRSLKEILWKRWAVIHVIHFADTALMIVFWISLLGKCPLVYVIPLFILFRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKKNTAKPETIPDMEDSPPVSDSEEQQESVRAAPEKSTKPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASAKKEDLKPRHDSSPSDPVPNTADEGIAEILPENASEPDLENMSSLNQERKCFPGPPGDGHPEPSPLDGLSPCSASGGSGVVTTVTVSGRDPRTALSGSCTVTASMAAHLDNSHTSETKLDTLKPALTPAVVPKSILAKPSSSPDPRYLSVPPSPNMSISESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAKDPVPSKLLPFEGPGLESQRPNIILGLVICQKVKRPTSAGELDKTDEKRARLQQEEAETSVYPKVAATLPSEKKPPKYHLHSADTAASSTTPPGSPPPPPPLPEPPVLKILSSLKPGSTSTVAAPTTSAVITTTAPPVVSASSKTASPLEHILQTLFGKKKSFEPSAKESVGSTLSPHQDPKAKGEDAVSSAAPLLDPIVQQFGQFSKDKALEEEEEGDDRPYDPEEEYNPERAFHTLLAEPGRRHDVENVPETAEREEVAYDPEDETILEEAKVTIDDLPNRMCVKVSSTERPADFATDATNPSLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGASMAHFSVSDALMSPPPKSSLAKTDLFSQEQQAQDPSHGALGANHSLDSRHSRDPRQARRLAAENTESEPLPRAPTGSTPGPQGTLPAREMPAAGTAAVQGPALAPEAKESEAVPWAPGENAVLRPEHDMQKCEHPGNPVSLPLDNSHLPAAGDGASRPTAPRRVLLPTPPSTAFPPSFPLQPEAQNFTSGGREPFPGPMFLSQETSLGSSQYEDTRGAQSAGRSDSPVADTEDSREPQLRTGEGTTQFPQPGQRGGGPQPQFPAQREPLPRTFGMSGHHGPGFPGPRGPVPPFSEESIVPNNDGPRGPPPARFGAQKPPIPSLFSGQHGPPPYGDNRGLSPSYLGGPRGGAPAQFEERKDPHGEKREFQDTPYNEMAGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLLTQMKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPSQFETPRGPHPGQFEGPRGQAPGFMPGPRGVQPQQFEEQRVNSPPRFAGQRAPAPLPYGGPRGPAPFAEKNEQPPSRFHFQGQSSQPVKPPPRPLLELPSHPPQHRKDRWDDAGPATALPSGAGSGQGPEADGQWATPEFREGKGHEYRSPAFEGRQRERFEGGPKEKPLDEPEAQGLENRQGRAFEDRRRERGRNWSRERDWERSREWDRHREWDKGRDRSSNRDRERDADRAKDWDRNRERSRNRDRDRERRRDRDRSRSRDRDRDRERARDRDRDRGRDRKDRSKSRESPRDLKSEARTSDGGPATAQA", "length": 2302 }, "evidence": [ { "id": "E1BCR2", "url": "https://omabrowser.org/oma/group/E1BCR2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8C9B9-1", "protein_name": "Death-inducer obliterator 1", "gene_name": "Dido1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDDKGHLSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDTEVDPSEQQPQQHNLSLRRSGRQPKRTERVEEFLTTVRRRGKKNVPVSLEDSSEPTSSTVTDVETASEGSVESSSEIRSGPVSDSLGKEHPASSEKAKGGEEEEDTSDSDSDGLTLKELQNRLRRKREQEPVERSLRGSQNRLRKKRREEDSAETGSVQIGSAEQDRPLCKQEPEASQGPVSQSETDDIENQLEGKATQGNTEENPREAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETNGSATDEQDSGCRSVGADGTDCTSIGTVEQKSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAPKCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCSVQVGIKISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKPTALSPTLLSKSMKDDRRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPAIKKLPSGFKGTIPKRPWPSATLSGTSARQAGPTPMTAASKKLPGSAAVVGVTRKPMSANVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKKNTTKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTADEGIADTLPENASEPDPESTSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSGRDPRTALSGSCTVTASMAAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPPSPSISESRSPPEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGELDKTDEKRTRLQQEELETSVYPKVTAALPSEKKPPKYSVHSIDTAATSTTPPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTAPTTAAITTTASPVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLSPHQDSKAKGEDTMSAAPLLDPIVQQFGQFSKDKALEEEEEDDRPYDPEEEYNPDRAFHTLLAEPGRPHDVQSVSETAEREEVAYDPEDETILEEAKVTIDDLPNRMCMKVSATERPADFTTDASSASLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQAPDPSQGAPNTNHNLDSRQSRDPRQARRLAAENTENESLPRAPTGSTPGPQGTLPARETPAGTAVVQGPGLAAEAKESMAVPWAPGENAVLRPEHDIQKCEHPGNPVSLPLDTSHLPTAGDGAARPAPPRRVLLPTPPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFMSQETSLGSSQYEDPRGAQSAGKNDSPVADMEDSREPQPRPGESTTSFPQPGQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPYSEENLVPNSDGPRGPPPARFGAQKPPIPSLFSGQHGPPPYGDNRGLSPSYLGGPRGGAPAQFEDRKDPHGEKREFQDTPYNEMTGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLLTQMKGPRGGPPPSQFGAQRGPPPGHFVGPRGPHPSQFENSRGTHPGQFEGARGQAPGFMPGPRGIQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQPPSRFHFQGPSSQPVKPPPRPLLELPSHPPQHRKDRWDEAGPATALPSSAGPGQGHEADGQWATSEFREGKGHEYRSPAFEGRQRERFEAGSKEKPLDEPEAQGLESRQGRAFEDRRRERERGRNWSRERDWERSRDWDRHREWDKGRDRSSNRDRERDNDRAKEWDRSRERSRNRDRDRERRRDRDRSRSRDRDRDRERARDRDRDRGRDRKDRSKSRESPRDQKPEARTSEGGPAAAQA", "length": 2256 }, "evidence": [ { "id": "E1BCR2", "url": "https://omabrowser.org/oma/group/E1BCR2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BTC0-4", "protein_name": "Death-inducer obliterator 1", "gene_name": "DIDO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDDKGDPSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQLGLSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASETRSGPQSASTAVKERPASSEKVKGGDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKHAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSADEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNIILGLVICQKIKRPANSGELDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQTLFGKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVTVDDLPNRMCADVRRNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDPRQARRLATETGEGEGEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGERDPFTCPGFASQDKALGSAQYEDPRNLHSAGRSSSPAGETEGDREPQARPGEGTAPLPPPGQKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARFGAQKGPIPSLFSGQHGPPPYGDSRGPSPSYLGGPRGVAPSQFEERKDPHGEKREFQDAPYNEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVHSPPRFTNQRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPLLELPSHPPQHRKDRWEEAGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKESARDPKPEASRASDAGTASQA", "length": 2240 }, "evidence": [ { "id": "E1BCR2", "url": "https://omabrowser.org/oma/group/E1BCR2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ], "pmid": "" }, { "name": "apoptotic signaling pathway", "id": "GO:0097190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097190", "evidence": [ { "database": "UniProtKB", "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCR2", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1153, "end_pos": 1155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1572, "end_pos": 1574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2123, "end_pos": 2125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 689, "end_pos": 691, "annotation": "n_glycosylation_sequon" }, { "start_pos": 789, "end_pos": 791, "annotation": "n_glycosylation_sequon" }, { "start_pos": 912, "end_pos": 914, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 267, "end_pos": 321, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR2" }, { "id": "PS51321", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51321" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TFIIS central", "eco_id": "ECO_0000259", "start_pos": 672, "end_pos": 792, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 952, 1611 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1153, "end_pos": 1155 }, { "start_pos": 1572, "end_pos": 1574 }, { "start_pos": 2123, "end_pos": 2125 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 689, "end_pos": 691 }, { "start_pos": 789, "end_pos": 791 }, { "start_pos": 912, "end_pos": 914 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N039-1", "uniprot_ac": "F1N039", "uniprot_id": "F1N039_BOVIN", "mass": { "chemical_mass": 53817.0, "monoisotopic_mass": 53817.0 }, "refseq": {}, "gene_names": [ { "name": "GAL3ST4", "type": "recommended", "evidence": [ { "id": "F1N039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N039" } ] } ], "protein_names": [ { "name": "Galactose-3-O-sulfotransferase 4", "type": "recommended", "evidence": [ { "id": "F1N039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N039/entry#names_and_taxonomy" } ] }, { "name": "Beta-galactose-3-O-sulfotransferase 4", "type": "synonym", "evidence": [ { "id": "F1N039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N039/entry#names_and_taxonomy" } ] }, { "name": "Gal-beta-1,3-GalNAc 3'-sulfotransferase", "type": "synonym", "evidence": [ { "id": "F1N039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N039/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N039", "url": "https://www.uniprot.org/uniprotkb/F1N039" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAL3ST4", "url": "https://www.uniprot.org/uniprotkb/F1N039", "locus": { "chromosome": "25", "start_pos": 36247358, "end_pos": 36241705, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015017", "url": "https://www.ensembl.org/id/ENSBTAG00000015017" } ] } } ], "crossref": [ { "id": "F1N039", "url": "https://alphafold.ebi.ac.uk/entry/F1N039", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015017", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015017", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR009729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RTMRLWG", "url": "https://omabrowser.org/oma/group/RTMRLWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAW0", "url": "https://www.orthodb.org/?gene=A0A3Q1MAW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N039", "url": "https://www.orthodb.org/?gene=F1N039", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14647", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14647", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14647:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14647:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06990", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06990", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MAW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N039", "url": "https://www.uniprot.org/uniprotkb/F1N039", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N039-1", "url": "https://www.uniprot.org/uniprotkb/F1N039-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVLSPTRTMRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRHSWASSLGPAAPSCPPRQHLVFLKTHKSGSSSVLSLLHRYGDRHGLRFALPARYQFGYPRLFQASRVKGYRPQSGGTQPPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKAPSLAAFLANPRAFYRPGARGDHYARNLLWFDFGLPFPPELRTKRGNPHVSRDPNPPQLPSGAGPPAHTLDPNALFHPVPTVADGHSQMSSPASLDLGSSSFIQWNLAWLDSVFDLVLVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGGGQDRSTIDDGGLTTEERQLTARARAWNNLDWALYVHFNRSLWARIKQYGQSRLDSAVAELRARREALAKHCLVGGEALDPKYITDRRFRPFQFGSGKVLGYVLRSGLSLQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKTSRRPSP", "length": 483, "header": "tr|F1N039-1|F1N039_BOVIN Isoform 1 of Galactose-3-O-sulfotransferase 4 OS=Bos taurus OX=9913 GN=GAL3ST4 PE=3 SV=1 CANONICAL=F1N039-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAW0/entry", "sequence": { "sequence": "MGVLSPTRTMRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRHSWASSLGPAAPSCPPRQHLVFLKTHKSGSSSVLSLLHRYGDRHGLRFALPARYQFGYPRLFQASRVKGYRPQSGGTQPPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKAPSLAAFLANPRAFYRPGARGDHYARNLLWFDFGLPFPPELRTKRGNPHVSRDPNPPQLPSGAGPPAHTLDPNALFHPVPTVADGHSQMSSPASLDLGSSSFIQWNLAWLDSVFDLVLVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGGGQDRSTIDDGGLTTEERQLTARARAWNNLDWALYVHFNRSLWARIKQYGQSRLDSAVAELRARREALAKHCLVGGEALDPKYITDRRFRPFQFGSGPSCTFEGLLEEQTMEYDRESLGHKGSEYV", "length": 458, "header": "tr|A0A3Q1MAW0-1|F1N039_BOVIN Computationally mapped isoform of Galactose-3-O-sulfotransferase 4 OS=Bos taurus OX=9913 GN=GAL3ST4 PE=3 SV=2 CANONICAL=F1N039-1" }, "locus": { "chromosome": "25", "start_pos": 36247275, "end_pos": 36243109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084788.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084788.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067385.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067385.2" } ] } }, { "isoform_ac": "F1N039-1", "url": "https://www.uniprot.org/uniprotkb/F1N039/entry", "sequence": { "sequence": "MGVLSPTRTMRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRHSWASSLGPAAPSCPPRQHLVFLKTHKSGSSSVLSLLHRYGDRHGLRFALPARYQFGYPRLFQASRVKGYRPQSGGTQPPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKAPSLAAFLANPRAFYRPGARGDHYARNLLWFDFGLPFPPELRTKRGNPHVSRDPNPPQLPSGAGPPAHTLDPNALFHPVPTVADGHSQMSSPASLDLGSSSFIQWNLAWLDSVFDLVLVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGGGQDRSTIDDGGLTTEERQLTARARAWNNLDWALYVHFNRSLWARIKQYGQSRLDSAVAELRARREALAKHCLVGGEALDPKYITDRRFRPFQFGSGKVLGYVLRSGLSLQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKTSRRPSP", "length": 483, "header": "tr|F1N039-1|F1N039_BOVIN Isoform 1 of Galactose-3-O-sulfotransferase 4 OS=Bos taurus OX=9913 GN=GAL3ST4 PE=3 SV=1 CANONICAL=F1N039-1" }, "locus": { "chromosome": "25", "start_pos": 36246930, "end_pos": 36243109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019991.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019991.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019991.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019991.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MZR9-1", "protein_name": "Galactose-3-O-sulfotransferase 4", "gene_name": "Gal3st4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGPLSPARTMRLWRPRSLGVALGVFMTIGFGLQLLGGPFQRRLPVLQLRQSWIPSLGPTMKSCLPRQRLVFLKTHKSGSSSVLSLLHRYGDQQGLRFALPAHYQFGYPKLFQASKVKGYHPQSSDTKKPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKAPSLAAFLSNPQAFYRPGGRGNHYARNLLWFDFGLPFPPERRVSSHLPRDPNPLQLHIVPSGAGLGTLFQPMSTVANNNAQPASFASSDFGPSSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWGLDDVVGFMHNAQARSEQRLSAANKSVANEEQQLTARARAWNNLDWALYTHFNRSLWARIEQYGHSRLQRAVAEIRARREALAKRCLMGGEALDPKYITDVRLRPFQFGSAKVLGYVLQSGLSQKEQEECERLATPELQYKDKLDAKQFSPTVSLPLKTSRTLPP", "length": 475 }, "evidence": [ { "id": "F1N039", "url": "https://omabrowser.org/oma/group/F1N039/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZHZ0-1", "protein_name": "Galactose-3-O-sulfotransferase 4", "gene_name": "Gal3st4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGPLSPARTMRLWRPRSLGVALGVFMTIGFGLQFLGGSFQRRLPGLQFRQSWIPSLGPTVKSCLPRQRLVFLKTHKSGSSSVLNLLHRYGDQQGLRFALPAHYQFGYPKLFQASKVKGYHPQSSDTQKPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSASSAFRKAPSLAAFLSNPRAFYRPGARGNHYARNLLWFDFGLPFPPETKTMRVSPHLPRDPKSLQLHIVPSGASPGTLFRPITTAADSYKQPASLASSDFGPSSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWSLDDVVGFMHNAQAGSEQSILSTANKTVATGEDQQLTKQARAWNNLDWALYIHFNRSLWARIEQYGRSRLQRAVAELRARREALARRCLMGGEALDPKYITDVRLRPFQFGSAKVLGYVLQNGLNQKDQEECERLATPELQYKDKLDAKQFPPVVSLPLKTSKPLTP", "length": 480 }, "evidence": [ { "id": "F1N039", "url": "https://omabrowser.org/oma/group/F1N039/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RNN6-1", "protein_name": "Galactose-3-O-sulfotransferase 4", "gene_name": "GAL3ST4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGHLSSTRTMRLWGPRSLGVALGVFMTIGFALQFWGGPFQRRLPGLQLRQSWAPSPGLALPSCSPRQRLVFLKTHKSGSSSVLSLLHRYGDRHGLRFALPARYQFGYPRLFEASRVKGYRPQGGGTQPPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALTRSAFSYYKSTSSAFRKAPSLAAFLANPRAFYRPGARGDHYARNLLWFDFGLPFPPEMRTKRGNPRPPRDPKAPQLRVLPSGAGPPAHTLDPNALFHPVPTLADGHSRTSSPASSDLGSSSFIQWSLAWLDSVFDLVLVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGGRQSGSAVSDDGLTAEDRQLTARARAWNNLDWALYVHFNHSLWERIKQYGQSRLDSAVAELRARREALAKHCLVGGEALDPKYITDRRFRPFQFGSGKVLGYVLRSGLSLQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKNSRLSSP", "length": 486 }, "evidence": [ { "id": "F1N039", "url": "https://omabrowser.org/oma/group/F1N039/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycolipid biosynthetic process", "id": "GO:0009247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009247", "evidence": [ { "database": "UniProtKB", "id": "F1N039", "url": "https://www.uniprot.org/uniprotkb/F1N039" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "F1N039", "url": "https://www.uniprot.org/uniprotkb/F1N039" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "galactosylceramide sulfotransferase activity", "id": "GO:0001733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001733", "evidence": [ { "database": "UniProtKB", "id": "F1N039", "url": "https://www.uniprot.org/uniprotkb/F1N039" } ], "pmid": "" }, { "name": "galactose 3-O-sulfotransferase activity", "id": "GO:0050694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050694", "evidence": [ { "database": "UniProtKB", "id": "F1N039", "url": "https://www.uniprot.org/uniprotkb/F1N039" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N039-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 483, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N039-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N039" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 371, "end_pos": 373 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N032-1", "uniprot_ac": "F1N032", "uniprot_id": "F1N032_BOVIN", "mass": { "chemical_mass": 215598.0, "monoisotopic_mass": 215598.0 }, "refseq": { "ac": "XP_002689611", "name": "DENN domain-containing protein 4C isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689611" }, "gene_names": [ { "name": "DENND4C", "type": "recommended", "evidence": [ { "id": "F1N032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ] }, { "name": "DENND4C", "type": "synonym", "evidence": [ { "id": "XP_002689611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689611" } ] } ], "protein_names": [ { "name": "DENN domain containing 4C", "type": "synonym", "evidence": [ { "id": "F1N032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N032/entry#names_and_taxonomy" } ] }, { "name": "DENN domain-containing protein 4C isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689611" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENND4C", "url": "https://www.uniprot.org/uniprotkb/F1N032", "locus": { "chromosome": "8", "start_pos": 24922729, "end_pos": 25039881, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003097", "url": "https://www.ensembl.org/id/ENSBTAG00000003097" } ] } } ], "crossref": [ { "id": "ENSBTAG00000003097", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003097", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536760", "url": "https://www.ncbi.nlm.nih.gov/gene/536760", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536760", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536760", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NBE4", "url": "https://www.orthodb.org/?gene=A0A3Q1NBE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N032", "url": "https://www.orthodb.org/?gene=F1N032", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12296:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12296:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002689611", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689611", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBE4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBE4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N032-1", "url": "https://www.uniprot.org/uniprotkb/F1N032-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIENKGPRVVDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPITDIAVINKSAGETVPEGYTCVEATPSGLQANLNYGSLKSPELFLCYKRGREKPPLTDIGVLYDGKERLIPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPLIRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSECVPLFCLPMGATIECWDPQSKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSRELLTEKQLMHLGLLTPVERKMVSKSINSNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLLLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYLSDEKKNMNWKQLPKKPCKNLISTLKKLYPQLFSVHRKTQEGSAIEMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDVDSAEDTKLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGSSITNSPALMAKRTKQEIKTAHKLARRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTAKIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKNTVQKSQVSSISAPQNATGGSDGDTVSHGSVDSSNDANSGEHTVFVRDLIRLDSADNHSSTGGQSDQGYGSKDELLKDDAEIHVPEEQISGDLITKTEEVCNVSAVVAKHSQPSAESQSPAEPPAWGSSIVKVPSGIFDINGRKSSTGSTSSVLFSSQDPVEDAVFGEVINLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEVAIMMGADAKILTALTSPKASPLHNARAHSFGSISCHPSDTRTRASESTWDSEHRLSVLEMLEESQELIEPGVDENVAKAAMTKDTCDSLQNDSNQSRDSKAGSRDLANKRNSLYGVAKAVEREDVETGLDPLSLLATECIGEKTDSEEKLFSPVIARNLADEIESYMNLKSPLGSKSPSMELHGEGSRESGATSTFIHSLERRSSLPLDHGPPAQESPGSEKGSPAVSRSKTSTGHLKQQTPSRSPKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKMDVLKSGMKQAATVASKMWVAVASAYNYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDIGKLHYSPGELPFLRGMKGQEFEKSDHGSSPNTSMSSIYQNCAMEVLMSSCSQCRVCAALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLASEPLEHKPISSPAEPDLINLTDLPKHNQTITEETSSAVESSDEIMKASGDVQTMKISPVPNSLSKRNVSLTRSHSVGGPLQNMDFSQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVAWRNFNSEKKSSLLSEEQQATSTLVEIIRQSIQHNDVLKPINLLAQQMKGDVKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYNSLSPDILEKLQKIDAPPSISVEWCRKCFGMLLI", "length": 1949, "header": "tr|F1N032-1|F1N032_BOVIN Isoform 1 of DENN domain containing 4C OS=Bos taurus OX=9913 GN=DENND4C PE=4 SV=3 CANONICAL=F1N032-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NBE4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBE4/entry", "sequence": { "sequence": "MIENKGPRVVDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPITDIAVINKSAGETVPEGYTCVEATPSGLQANLNYGSLKSPELFLCYKRGREKPPLTDIGVLYDGKERLIPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPLIRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSECVPLFCLPMGATIECWDPQSKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSRELLTEKQLMHLGLLTPVERKMVSKSINSNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLLLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYLSDEKKNMNWKQLPKKPCKNLISTLKKLYPQLFSVHRKTQEGSAIEMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDVDSAEDTKLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGSSITNSPALMAKRTKQEIKTAHKLARRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTAKIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKNTVQKSQVSSISGGQSDQGYGSKDELLKDDAEIHVPEEQISGDLITKTEEVCNVSAVVAKHSQPSAESQSPAEPPAWGSSIVKVPSGIFDINGRKSSTGSTSSVLFSSQDPVEDAVFGEVINLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEVAIMMGADAKILTALTSPKASPLHNARAHSFGSISCHPSDTRTRASESTWDSEHRLSVLEMLEESQELIEPGVDENVAKAAMTKDTCDSLQNDSNQSRDSKAGSRDLANKRNSLYGVAKAVEREDVETGLDPLSLLATECIGEKTDSEEKLFSPVIARNLADEIESYMNLKSPLGSKSPSMELHGEGSRESGATSTFIHSLERRSSLPLDHGPPAQESPGSEKGSPAVSRSKTSTGHLKQQTPSRSPKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKMDVLKSGMKQAATVASKMWVAVASAYNYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDIGKLHYSPGELPFLRGMKGQEFEKSDHGSSPNTSMSSIYQNCAMEVLMSSCSQCRVCAALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLASEPLEHKPISSPAEPDLINLTDLPKHNQTITEETSSAVESSDEIMKASGDVQTMKISPVPNSLSKRNVSLTRSHSVGGPLQNMDFSQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVAWRNFNSEKKSSLLSEEQQATSTLVEIIRQSIQHNDVLKPINLLAQQMKGDVKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYNSLSPDILEKLQKIDAPPSISVEWCRKCFGMLLI", "length": 1900, "header": "tr|A0A3Q1NBE4-1|F1N032_BOVIN Computationally mapped isoform of DENN domain containing 4C OS=Bos taurus OX=9913 GN=DENND4C PE=4 SV=2 CANONICAL=F1N032-1" }, "locus": { "chromosome": "8", "start_pos": 25007604, "end_pos": 24923733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073212.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073212.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068643.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068643.2" } ] } }, { "isoform_ac": "F1N032-1", "url": "https://www.uniprot.org/uniprotkb/F1N032/entry", "sequence": { "sequence": "MIENKGPRVVDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPITDIAVINKSAGETVPEGYTCVEATPSGLQANLNYGSLKSPELFLCYKRGREKPPLTDIGVLYDGKERLIPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPLIRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSECVPLFCLPMGATIECWDPQSKYPLPVFSTFVLTGSSAEKVYGAAIQFYEPYSRELLTEKQLMHLGLLTPVERKMVSKSINSNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLLLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYLSDEKKNMNWKQLPKKPCKNLISTLKKLYPQLFSVHRKTQEGSAIEMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDVDSAEDTKLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGSSITNSPALMAKRTKQEIKTAHKLARRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTAKIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKNTVQKSQVSSISAPQNATGGSDGDTVSHGSVDSSNDANSGEHTVFVRDLIRLDSADNHSSTGGQSDQGYGSKDELLKDDAEIHVPEEQISGDLITKTEEVCNVSAVVAKHSQPSAESQSPAEPPAWGSSIVKVPSGIFDINGRKSSTGSTSSVLFSSQDPVEDAVFGEVINLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEVAIMMGADAKILTALTSPKASPLHNARAHSFGSISCHPSDTRTRASESTWDSEHRLSVLEMLEESQELIEPGVDENVAKAAMTKDTCDSLQNDSNQSRDSKAGSRDLANKRNSLYGVAKAVEREDVETGLDPLSLLATECIGEKTDSEEKLFSPVIARNLADEIESYMNLKSPLGSKSPSMELHGEGSRESGATSTFIHSLERRSSLPLDHGPPAQESPGSEKGSPAVSRSKTSTGHLKQQTPSRSPKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKMDVLKSGMKQAATVASKMWVAVASAYNYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDIGKLHYSPGELPFLRGMKGQEFEKSDHGSSPNTSMSSIYQNCAMEVLMSSCSQCRVCAALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLASEPLEHKPISSPAEPDLINLTDLPKHNQTITEETSSAVESSDEIMKASGDVQTMKISPVPNSLSKRNVSLTRSHSVGGPLQNMDFSQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVAWRNFNSEKKSSLLSEEQQATSTLVEIIRQSIQHNDVLKPINLLAQQMKGDVKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYNSLSPDILEKLQKIDAPPSISVEWCRKCFGMLLI", "length": 1949, "header": "tr|F1N032-1|F1N032_BOVIN Isoform 1 of DENN domain containing 4C OS=Bos taurus OX=9913 GN=DENND4C PE=4 SV=3 CANONICAL=F1N032-1" }, "locus": { "chromosome": "8", "start_pos": 25007604, "end_pos": 24923733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004032.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004032.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004032.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004032.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536760", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536760", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of Rab protein signal transduction", "id": "GO:0032483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032483", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" }, { "name": "insulin-responsive compartment", "id": "GO:0032593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032593", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N032", "url": "https://www.uniprot.org/uniprotkb/F1N032" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1000, "end_pos": 1002, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1109, "end_pos": 1111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1204, "end_pos": 1206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1207, "end_pos": 1209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1425, "end_pos": 1427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1451, "end_pos": 1453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1455, "end_pos": 1457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1470, "end_pos": 1472, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1513, "end_pos": 1515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1624, "end_pos": 1626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1632, "end_pos": 1634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1672, "end_pos": 1674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 914, "end_pos": 916, "annotation": "n_glycosylation_sequon" }, { "start_pos": 955, "end_pos": 957, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N032" }, { "id": "PS51498", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51498" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MABP", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 199, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N032" }, { "id": "PS50211", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UDENN", "eco_id": "ECO_0000259", "start_pos": 191, "end_pos": 640, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 67 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1000, "end_pos": 1002 }, { "start_pos": 1109, "end_pos": 1111 }, { "start_pos": 1204, "end_pos": 1206 }, { "start_pos": 1207, "end_pos": 1209 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 131, "end_pos": 133 }, { "start_pos": 1425, "end_pos": 1427 }, { "start_pos": 1451, "end_pos": 1453 }, { "start_pos": 1455, "end_pos": 1457 }, { "start_pos": 1470, "end_pos": 1472 }, { "start_pos": 1513, "end_pos": 1515 }, { "start_pos": 1624, "end_pos": 1626 }, { "start_pos": 1632, "end_pos": 1634 }, { "start_pos": 1672, "end_pos": 1674 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 914, "end_pos": 916 }, { "start_pos": 955, "end_pos": 957 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0A1-1", "uniprot_ac": "F1N0A1", "uniprot_id": "F1N0A1_BOVIN", "mass": { "chemical_mass": 26820.0, "monoisotopic_mass": 26820.0 }, "refseq": { "ac": "XP_010809806", "name": "CCN family member 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809806" }, "gene_names": [ { "name": "CCN5", "type": "recommended", "evidence": [ { "id": "F1N0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ] }, { "name": "CCN5", "type": "synonym", "evidence": [ { "id": "XP_010809806", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809806" } ] }, { "name": "WISP2", "type": "synonym", "evidence": [ { "id": "XP_010809806", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809806" } ] } ], "protein_names": [ { "name": "CCN family member 5", "type": "recommended", "evidence": [ { "id": "F1N0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A1/entry#names_and_taxonomy" } ] }, { "name": "CCN family member 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010809806", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809806" } ] }, { "name": "Connective tissue growth factor-like protein", "type": "synonym", "evidence": [ { "id": "F1N0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A1/entry#names_and_taxonomy" } ] }, { "name": "WNT1-inducible-signaling pathway protein 2", "type": "synonym", "evidence": [ { "id": "F1N0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RSE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE9#function" }, { "database": "UniProtKB", "id": "ARBA00056453", "url": "https://www.uniprot.org/uniprotkb/ARBA00056453#function" }, { "database": "UniProtKB", "id": "A0AAA9S0I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0I6#function" }, { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCN5", "url": "https://www.uniprot.org/uniprotkb/F1N0A1", "locus": { "chromosome": "13", "start_pos": 73125584, "end_pos": 73110996, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006037", "url": "https://www.ensembl.org/id/ENSBTAG00000006037" } ] } } ], "crossref": [ { "id": "F1N0A1", "url": "https://alphafold.ebi.ac.uk/entry/F1N0A1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006037", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006037", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534658", "url": "https://www.ncbi.nlm.nih.gov/gene/534658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043973", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043973", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GIPCPEW", "url": "https://omabrowser.org/oma/group/GIPCPEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0A1", "url": "https://www.orthodb.org/?gene=F1N0A1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11348", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11348", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11348:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11348:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00219", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00219", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010809806", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809806", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RSE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0I6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0A1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGTFQTHLLAFSLLCLLSKVCAQLCPTPCACPWPPPRCPPGVPLVLDGCNCCRVCARRLGEPCDHLHVCDPSQGLVCQPGAGPGGRGAVCLWGEDDGSCEVNGRLYRDGETFQPHCRLRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVPGKCCPEWVCDQGVGLGVQPLPAQGSQFSGLVAPPAPGVPCPEWSTAWGPCSTTCGLGVATRVSNQNRFCRLETQQRLCVLGPCPPARGHSPRSRAF", "length": 250, "header": "tr|F1N0A1-1|F1N0A1_BOVIN Isoform 1 of CCN family member 5 OS=Bos taurus OX=9913 GN=CCN5 PE=3 SV=1 CANONICAL=F1N0A1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE9/entry", "sequence": { "sequence": "ALGIGTGSDFHTHAHTHTHTRARTHTYWQAPSWWPRRSHLQVCAQLCPTPCACPWPPPRCPPGVPLVLDGCNCCRVCARRLGEPCDHLHVCDPSQGLVCQPGAGPGGRGAVCLWGEDDGSCEVNGRLYRDGETFQPHCRLRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVPGKCCPEWVCDQGVGLGVQPLPAQGSQFSGLVAPPAPGVPCPEWSTAWGPCSTTCGLGVATRVSNQNRFCRLETQQRLCVLGPCPPARGHSPRSRAF", "length": 271, "header": "tr|A0AAA9RSE9-1|F1N0A1_BOVIN Computationally mapped isoform of CCN family member 5 OS=Bos taurus OX=9913 GN=CCN5 PE=3 SV=1 CANONICAL=F1N0A1-1" }, "locus": { "chromosome": "13", "start_pos": 73124845, "end_pos": 73110998, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123668.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123668.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075480.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075480.1" } ] } }, { "isoform_ac": "A0AAA9S0I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0I6/entry", "sequence": { "sequence": "MGRGSRTSGPESRRSRLHSQPNLVTQGSLSPLLTSFLLSLLRSHPSPKQPTSLLIHPDLAIFQSRAQTAPPLISPPRFFKPEVTTLSQNPHDTLGKMKGQLSISGVRCIRPCTKHLPPKSHDPHNNLCGGEDDGSCEVNGRLYRDGETFQPHCRLRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVPGKCCPEWVCDQGVGLGVQPLPAQGSQFSGLVAPPAPGVPCPEWSTAWGPCSTTCGLGVATRVSNQNRFCRLETQQRLCVLGPCPPARGHSPRSRAF", "length": 286, "header": "tr|A0AAA9S0I6-1|F1N0A1_BOVIN Computationally mapped isoform of CCN family member 5 OS=Bos taurus OX=9913 GN=CCN5 PE=3 SV=1 CANONICAL=F1N0A1-1" }, "locus": { "chromosome": "13", "start_pos": 73124845, "end_pos": 73115665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113041.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113041.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078489.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078489.1" } ] } }, { "isoform_ac": "F1N0A1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1/entry", "sequence": { "sequence": "MRGTFQTHLLAFSLLCLLSKVCAQLCPTPCACPWPPPRCPPGVPLVLDGCNCCRVCARRLGEPCDHLHVCDPSQGLVCQPGAGPGGRGAVCLWGEDDGSCEVNGRLYRDGETFQPHCRLRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVPGKCCPEWVCDQGVGLGVQPLPAQGSQFSGLVAPPAPGVPCPEWSTAWGPCSTTCGLGVATRVSNQNRFCRLETQQRLCVLGPCPPARGHSPRSRAF", "length": 250, "header": "tr|F1N0A1-1|F1N0A1_BOVIN Isoform 1 of CCN family member 5 OS=Bos taurus OX=9913 GN=CCN5 PE=3 SV=1 CANONICAL=F1N0A1-1" }, "locus": { "chromosome": "13", "start_pos": 73124845, "end_pos": 73111319, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007931.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007931.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007931.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007931.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 28, "start_aa": "Thr", "end_pos": 28, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BT12-1", "protein_name": "CCN family member 5", "gene_name": "CCN5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGGTAQTLILAFSLLCLLSKVCAQLCPTPCACPWPPPRCPPGVPLVLDGCNCCRVCARRLGEPCDHLHICDSSQGLVCQLGAGPGSRGAVCLWGEDDGSCEVNGRLYRDGETFQPHCRIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVPGKCCPEWVCDPQPLPARGPQFSGLVAPPVPGIPCPEWSTAWGPCSTTCGLGVATRVSNQNRFCRLETQRRLCLPGPCPPARGHSPRNSAF", "length": 244 }, "evidence": [ { "id": "F1N0A1", "url": "https://omabrowser.org/oma/group/F1N0A1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MPZ6-1", "protein_name": "CCN family member 5", "gene_name": "LOC100756544", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRDTPLTHLLAISFLCLLSMVCAQLCPTSCTCPWTPPQCPVGVPLVLDGCGCCQVCARRLGESCDHLHVCDSSQGLVCQPGAGPGGREATCLLEEEDGSCEVNGHRYLDGETFQPNCRVLCRCNDGGFTCLPLCSEDVRLPSWDCPRPRRVEVPGRCCPEWVCDQGVTPRIQPHTAQGHQLSGLVTPASADVPCPKISTAWGPCSTTCGLGIATRVSNQNRFCQLEIQRRLCLPRPCLAARSRSSWNGAF", "length": 250 }, "evidence": [ { "id": "F1N0A1", "url": "https://omabrowser.org/oma/group/F1N0A1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O76076-1", "protein_name": "CCN family member 5", "gene_name": "CCN5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF", "length": 250 }, "evidence": [ { "id": "F1N0A1", "url": "https://omabrowser.org/oma/group/F1N0A1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0G4-1", "protein_name": "CCN family member 5", "gene_name": "Ccn5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRGNPLIHLLAISFLCILSMVYSQLCPAPCACPWTPPQCPPGVPLVLDGCGCCRVCARRLGESCDHLHVCDPSQGLVCQPGAGPSGRGAVCLFEEDDGSCEVNGRRYLDGETFKPNCRVLCRCDDGGFTCLPLCSEDVRLPSWDCPRPRRIQVPGRCCPEWVCDQAVMQPAIQPSSAQGHQLSALVTPASADGPCPNWSTAWGPCSTTCGLGIATRVSNQNRFCQLEIQRRLCLSRPCLASRSHGSWNSAF", "length": 251 }, "evidence": [ { "id": "F1N0A1", "url": "https://omabrowser.org/oma/group/F1N0A1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" }, { "name": "positive regulation of cell differentiation", "id": "GO:0045597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045597", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "F1N0A1", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0A1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 250, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0A1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0A1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" }, { "id": "PS51323", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IGFBP N-terminal", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 103, "start_aa": "Cys", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A1" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 98, "end_pos": 164, "start_aa": "Gly", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 28 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Y7-1", "uniprot_ac": "F1N0Y7", "uniprot_id": "F1N0Y7_BOVIN", "mass": { "chemical_mass": 88415.0, "monoisotopic_mass": 88415.0 }, "refseq": { "ac": "XP_005216830", "name": "BMP/retinoic acid-inducible neural-specific protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216830" }, "gene_names": [ { "name": "BRINP3", "type": "recommended", "evidence": [ { "id": "F1N0Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ] }, { "name": "BRINP3", "type": "synonym", "evidence": [ { "id": "XP_005216830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216830" } ] }, { "name": "FAM5C", "type": "synonym", "evidence": [ { "id": "XP_005216830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216830" } ] } ], "protein_names": [ { "name": "BMP/retinoic acid inducible neural specific 3", "type": "synonym", "evidence": [ { "id": "F1N0Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7/entry#names_and_taxonomy" } ] }, { "name": "BMP/retinoic acid-inducible neural-specific protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005216830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216830" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRINP3", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7", "locus": { "chromosome": "16", "start_pos": 15631131, "end_pos": 15144282, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008420", "url": "https://www.ensembl.org/id/ENSBTAG00000008420" } ] } } ], "crossref": [ { "id": "F1N0Y7", "url": "https://alphafold.ebi.ac.uk/entry/F1N0Y7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008420", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008420", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531710", "url": "https://www.ncbi.nlm.nih.gov/gene/531710", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CQCGPRF", "url": "https://omabrowser.org/oma/group/CQCGPRF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0Y7", "url": "https://www.orthodb.org/?gene=F1N0Y7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15564", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15564", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15564:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15564:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01823", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01823", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25415", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25415", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005216830", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216830", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RTM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIWRSRAGAELFSLMAPWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSEGSDPSANSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKDNDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNIDFEESDEFKFFMKRLPMNYFLNTSTVMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDAAACLSCAPDNRTRCGTCNTGYMLSQGFCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRLEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYINPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWSLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS", "length": 766, "header": "tr|F1N0Y7-1|F1N0Y7_BOVIN Isoform 1 of BMP/retinoic acid inducible neural specific 3 OS=Bos taurus OX=9913 GN=BRINP3 PE=3 SV=2 CANONICAL=F1N0Y7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM3/entry", "sequence": { "sequence": "MCVRGTNDSWEFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSEGSDPSANSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKDNDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNIDFEESDEFKFFMKRLPMNYFLNTSTVMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDAAACLSCAPDNRTRCGTCNTGYMLSQGFCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRLEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYINPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWSLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS", "length": 697, "header": "tr|A0AAA9RTM3-1|F1N0Y7_BOVIN Computationally mapped isoform of BMP/retinoic acid inducible neural specific 3 OS=Bos taurus OX=9913 GN=BRINP3 PE=3 SV=1 CANONICAL=F1N0Y7-1" }, "locus": { "chromosome": "16", "start_pos": 15630778, "end_pos": 15385848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109661.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109661.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076362.1" } ] } }, { "isoform_ac": "F1N0Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7/entry", "sequence": { "sequence": "MIWRSRAGAELFSLMAPWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSEGSDPSANSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKDNDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNIDFEESDEFKFFMKRLPMNYFLNTSTVMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDAAACLSCAPDNRTRCGTCNTGYMLSQGFCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRLEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYINPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWSLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS", "length": 766, "header": "tr|F1N0Y7-1|F1N0Y7_BOVIN Isoform 1 of BMP/retinoic acid inducible neural specific 3 OS=Bos taurus OX=9913 GN=BRINP3 PE=3 SV=2 CANONICAL=F1N0Y7-1" }, "locus": { "chromosome": "16", "start_pos": 15630778, "end_pos": 15166537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011078.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011078.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011078.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011078.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NVI6-1", "protein_name": "BMP/retinoic acid inducible neural specific 3", "gene_name": "BRINP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIWRCSAGAELFSLMALWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSDGSDPSTNSSVVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVILPEYLQEHFVQAALSYIACNSEGEFICKDNDCWCQCGPKFPECNCPYMDIQAMEENLLRISETWNAYNSEFEESDEFKLFMKRLPMNYFLNTSTVMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFGLSKRCHKQPLIRMPKQRSSNYWLNRIQSFLYCNENGLLGSFSEETHTCTCPNDQVACHGFLPCTVGDGSACLSCAPDNRTRCGSCNAGYMLSQGICKPEVAESTEHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNNWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYVNPFGGSHSESWFMPVNENNFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS", "length": 766 }, "evidence": [ { "id": "F1N0Y7", "url": "https://omabrowser.org/oma/group/F1N0Y7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1TV71-1", "protein_name": "BMP/retinoic acid inducible neural specific 3", "gene_name": "BRINP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIWRSRAGAELFSLMALWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSEGSDSSTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKDNDCWCQCGPKFPECNCPSMDIQAMEENLLRTTETWKAYNMDFEESDEFKFFMKRLPMNYFLNTSTIMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTTFLPCTVGDAAACLTCAPDNRTRCGACNTGYMLSQGLCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYVNPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWSLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQAALQAFNAKLPNTVDYDTTKLCS", "length": 766 }, "evidence": [ { "id": "F1N0Y7", "url": "https://omabrowser.org/oma/group/F1N0Y7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q499E0-1", "protein_name": "BMP/retinoic acid-inducible neural-specific protein 3", "gene_name": "Brinp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIWRRRAGAELSSLMALWEWIVLSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRSEGSETSTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKDNDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNSDFEDSDEFKFFMKRLPMNYFLNTSTIMHLWTMDSNFQRRYEQLENSMKQLFLKAHRIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDASACLTCAPDNRTRCGTCNTGYMLSQGLCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYVNPFGGSHSESWFMPVSESSFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLRSRIKANGPNSNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS", "length": 766 }, "evidence": [ { "id": "F1N0Y7", "url": "https://omabrowser.org/oma/group/F1N0Y7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q76B58-1", "protein_name": "BMP/retinoic acid-inducible neural-specific protein 3", "gene_name": "BRINP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIWRSRAGAELFSLMALWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRAEGSDSTTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKENDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNSDFEESDEFKLFMKRLPMNYFLNTSTIMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDASACLTCAPDNRTRCGTCNTGYMLSQGLCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYVNPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTMDYDTTKLCS", "length": 766 }, "evidence": [ { "id": "F1N0Y7", "url": "https://omabrowser.org/oma/group/F1N0Y7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K1M7-1", "protein_name": "BMP/retinoic acid-inducible neural-specific protein 3", "gene_name": "Brinp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIWRRRAGAELSSLMALWEWIVLSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRPEGSETSTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKENDCWCLCGPKFPECNCPSMDIQAMEENLLRITETWKAYNSDFEDSDEFKFFMKRLPMNYFLNTSTIMHLWTMDSNFQRRYEQLENSMKQLFLKAHRIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDASACLTCAPDNRTRCGTCNTGYMLSQGLCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYINPFGGSHSESWFMPVSESSFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLRSRIKANGPNSNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTVDYDTTKLCS", "length": 766 }, "evidence": [ { "id": "F1N0Y7", "url": "https://omabrowser.org/oma/group/F1N0Y7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of neuron differentiation", "id": "GO:0045666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045666", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" }, { "name": "negative regulation of mitotic cell cycle", "id": "GO:0045930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045930", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" }, { "name": "central nervous system neuron differentiation", "id": "GO:0021953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021953", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y7", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" }, { "start_pos": 562, "end_pos": 564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 641, "end_pos": 643, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0Y7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 766, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0Y7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0Y7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y7" }, { "id": "SM00457", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00457" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MACPF", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 264, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 168, "end_pos": 170 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 456, "end_pos": 458 }, { "start_pos": 562, "end_pos": 564 }, { "start_pos": 609, "end_pos": 611 }, { "start_pos": 641, "end_pos": 643 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N176-1", "uniprot_ac": "F1N176", "uniprot_id": "F1N176_BOVIN", "mass": { "chemical_mass": 77984.0, "monoisotopic_mass": 77984.0 }, "refseq": { "ac": "NP_001192442", "name": "zinc finger protein 263", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192442" }, "gene_names": [ { "name": "ZNF263", "type": "recommended", "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ] }, { "name": "ZNF263", "type": "synonym", "evidence": [ { "id": "NP_001192442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192442" } ] } ], "protein_names": [ { "name": "Zinc finger protein 263", "type": "recommended", "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein FPM315", "type": "synonym", "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein with KRAB and SCAN domains 12", "type": "synonym", "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 263", "type": "synonym", "evidence": [ { "id": "NP_001192442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192442" } ] } ], "function": [ { "annotation": "Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RU34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU34#function" }, { "database": "UniProtKB", "id": "ARBA00053211", "url": "https://www.uniprot.org/uniprotkb/ARBA00053211#function" }, { "database": "UniProtKB", "id": "A0AAA9SFC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC9#function" }, { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF263", "url": "https://www.uniprot.org/uniprotkb/F1N176", "locus": { "chromosome": "25", "start_pos": 2744243, "end_pos": 2737629, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018625", "url": "https://www.ensembl.org/id/ENSBTAG00000018625" } ] } } ], "crossref": [ { "id": "F1N176", "url": "https://alphafold.ebi.ac.uk/entry/F1N176", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018625", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018625", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100138099", "url": "https://www.ncbi.nlm.nih.gov/gene/100138099", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138099", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138099", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQVTNQG", "url": "https://omabrowser.org/oma/group/QQVTNQG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N176", "url": "https://www.orthodb.org/?gene=F1N176", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RU34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N176-1", "url": "https://www.uniprot.org/uniprotkb/F1N176-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGPGFQDREGLLIVKLEEDSAWSQELPQPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLQPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRQKVTNRGRGTEMLLEEPLPLETAQESPSFKLEPMETERSPGRRLQELLGPGPKRDPQTVKERALSAPWLSLFPPEGNMEDKELTGPQLPESLEDVAMYISQEEWGRQHPSKRALSRDTVQESYENVDSLESQVPSQEALSTQVEHGGKPWHPSVQTCKEGLSSRTPAPGEEKFENQEECAQSASPESIHCQALLLGQARGEVPWSPEQGRPRDRAEKLWEPPTEDRMEQSLVGATSCKKLGRPTELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVECAEIFGGNPHFLSLHRAHLGEEAHKCLECGKSFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCAECGKSFSRSSHLVIHERTHEKERLYPFSECGEAVRDSTLFLTNPGTHPKAEKKLFQCLTCGKSFRQGMHLTRHQRTHTGEKPYKCNLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGEKPYKCSECGESFSRSSRLMSHQRTHTG", "length": 685, "header": "tr|F1N176-1|F1N176_BOVIN Isoform 1 of Zinc finger protein 263 OS=Bos taurus OX=9913 GN=ZNF263 PE=3 SV=3 CANONICAL=F1N176-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RU34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU34/entry", "sequence": { "sequence": "MASGPGFQDREGLLIVKLEEDSAWSQELPQPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLQPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRQKLPESLEDVAMYISQEEWGRQHPSKRALSRDTVQESYENVDSLESQVPSQEALSTQVEHGGKPWHPSVQTCKEGLSSRTPAPGEEKFENQEECAQSASPESIHCQALLLGQARGEVPWSPEQGRPRDRAEKLWEPPTEDRMEQSLVGATSCKKLGRPTELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVECAEIFGGNPHFLSLHRAHLGEEAHKCLECGKSFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCAECGKSFSRSSHLVIHERTHEKERLYPFSECGEAVRDSTLFLTNPGTHPKAEKKLFQCLTCGKSFRQGMHLTRHQRTHTGEKPYKCNLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGEKPYKCSECGESFSRSSRLMSHQRTHTG", "length": 600, "header": "tr|A0AAA9RU34-1|F1N176_BOVIN Computationally mapped isoform of Zinc finger protein 263 OS=Bos taurus OX=9913 GN=ZNF263 PE=3 SV=1 CANONICAL=F1N176-1" }, "locus": { "chromosome": "25", "start_pos": 2743432, "end_pos": 2737917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075564.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075564.1" } ] } }, { "isoform_ac": "A0AAA9SFC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC9/entry", "sequence": { "sequence": "MASGPGFQDREGLLIVKLEEDSAWSQELPQPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLQPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRQKVTNRGRGTEMLLEEPLPLETAQESPSFKLEPMETERSPGRRLQELLGPGPKRDPQTVKERESQVPSQEALSTQVEHGGKPWHPSVQTCKEGLSSRTPAPGEEKFENQEECAQSASPESIHCQALLLGQARGEVPWSPEQGRPRDRAEKLWEPPTEDRMEQSLVGATSCKKLGRPTELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVECAEIFGGNPHFLSLHRAHLGEEAHKCLECGKSFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCAECGKSFSRSSHLVIHERTHEKERLYPFSECGEAVRDSTLFLTNPGTHPKAEKKLFQCLTCGKSFRQGMHLTRHQRTHTGEKPYKCNLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGEKPYKCSECGESFSRSSRLMSHQRTHTG", "length": 618, "header": "tr|A0AAA9SFC9-1|F1N176_BOVIN Computationally mapped isoform of Zinc finger protein 263 OS=Bos taurus OX=9913 GN=ZNF263 PE=3 SV=1 CANONICAL=F1N176-1" }, "locus": { "chromosome": "25", "start_pos": 2743432, "end_pos": 2737917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093622.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093622.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082567.1" } ] } }, { "isoform_ac": "A0AAA9SGH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGH2/entry", "sequence": { "sequence": "MASGPGFQDREGLLIVKLEEDSAWSQELPQPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLQPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRQKHYLLPGFLSFLPKETWKTRS", "length": 149, "header": "tr|A0AAA9SGH2-1|F1N176_BOVIN Computationally mapped isoform of Zinc finger protein 263 OS=Bos taurus OX=9913 GN=ZNF263 PE=3 SV=1 CANONICAL=F1N176-1" }, "locus": { "chromosome": "25", "start_pos": 2739837, "end_pos": 2737917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132745.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132745.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082784.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082784.1" } ] } }, { "isoform_ac": "F1N176-1", "url": "https://www.uniprot.org/uniprotkb/F1N176/entry", "sequence": { "sequence": "MASGPGFQDREGLLIVKLEEDSAWSQELPQPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLQPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRQKVTNRGRGTEMLLEEPLPLETAQESPSFKLEPMETERSPGRRLQELLGPGPKRDPQTVKERALSAPWLSLFPPEGNMEDKELTGPQLPESLEDVAMYISQEEWGRQHPSKRALSRDTVQESYENVDSLESQVPSQEALSTQVEHGGKPWHPSVQTCKEGLSSRTPAPGEEKFENQEECAQSASPESIHCQALLLGQARGEVPWSPEQGRPRDRAEKLWEPPTEDRMEQSLVGATSCKKLGRPTELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVECAEIFGGNPHFLSLHRAHLGEEAHKCLECGKSFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCAECGKSFSRSSHLVIHERTHEKERLYPFSECGEAVRDSTLFLTNPGTHPKAEKKLFQCLTCGKSFRQGMHLTRHQRTHTGEKPYKCNLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGEKPYKCSECGESFSRSSRLMSHQRTHTG", "length": 685, "header": "tr|F1N176-1|F1N176_BOVIN Isoform 1 of Zinc finger protein 263 OS=Bos taurus OX=9913 GN=ZNF263 PE=3 SV=3 CANONICAL=F1N176-1" }, "locus": { "chromosome": "25", "start_pos": 2743432, "end_pos": 2737917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026911.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026911.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026911.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026911.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138099", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138099", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AS95-1", "protein_name": "Zinc finger protein 263", "gene_name": "ZNF263", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALGPAFQDREGLLIVKLEEDCAWSQELPPPDPRPSPEASHLRFRRFRFQEASGPREALSRLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQKELGRLRKKVTNHGRGTEVLLEEPLPLETAAESPSFKLEPMETERSPGPRLQELLGPSPQRDPQTVKERALSAPWLSLFPPGGNMEDKELTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDPLESQVPSQEALSTQVEQGRKPWDPNVQICKEGLSPRSPAPGEEKFENLEESAQSVSLENIHTQALLPGQARGEAPWSLEQRRPQDRAEEHRGLPPEDRMEQSFVGAASCRELGRPKELQPKKLHLCPLCGKNFSNNSNLMRHQRIHAAERLCLGVECAQIFGGNPHFLSLHKAHLGEEAHKCLECGKSFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCAECGKSFSRSSHLVIHERTHEKERLCPFSEGGQAVSDSSLFLTNHGTHKAEKKLFECLTCGKSFRQSMHLTRHQRTHTGEKPYQCTLCGENFSHRSNLIRHQRIHTGEKPYTCQECGDSFSHSSNRIRHLRTHTGERPYKCSQCGESFSRSSRLLSHQRTHTG", "length": 684 }, "evidence": [ { "id": "F1N176", "url": "https://omabrowser.org/oma/group/F1N176/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LCF0-1", "protein_name": "Zinc finger protein 263", "gene_name": "Znf263", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTMAAGPGSQEPEGLLIVKLEEDCTWSQEVPPPDPEPSPEASHLRFRRFRFQEAAGPREALSQLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELRPESGEEAVTLVERMQRELGKLRQQVTNQGRGAEVLLEEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPKRDPQAVKERALSAPWLSLFPPEGNMEDKDMTGSQLPENFEDVAMYISQEWGHQDPSKRALSREMVQDSYENVGTLESCIPGQEVISTQVEQGGKPWDPSVQSCKGGRSPRDPVPGVDKFENPERSVESVSPESAHPPVLLPGQARREVPWSPEQGRPDDREEGHWECPPEDKIEESLVGTTNCRGLVQPKEQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHIGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNVCGKSFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEKERLDPLPECGQGINNDSATFLTNHGAHRVEKKLFECLTCGKSFRQGMHLTRHQRTHTGEKPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLTSHQRTHTG", "length": 685 }, "evidence": [ { "id": "F1N176", "url": "https://omabrowser.org/oma/group/F1N176/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZQ68-1", "protein_name": "Zinc finger protein 263", "gene_name": "Zfp263", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSMAAGPSSQEPEGLLIVKLEEDCTWSQEVPPPEPEPSPEASHLRFRRFRFQDASGPREALNQLQELCRGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELRPESGEEAVTLVERMQKELGKLRQQVTNQGRGAEVLLEEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPKRDSQAVKERALSAPWLSLFPPEGNVEDKDMTGTQLPESLEDMAMYISQEWDHQDHSKRAPSRDMVQDSYENVGTLESCIPSQEVSSTQVEQGGKPWDPSVQTCKEGMNPRNPVLGVEKFENQERSVESVSPESTHPPVLLPGQARREVPWSPEQGRLDDREGHWECPPEDKIEESLMGTPSCRGLVQAKEQPKKLHLCALCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHVGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPFQCNVCGKSFSCNSNLNRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEKERLDPLPECGQGINDSAPFLTNHRVEKKLFECSTCGKSFRQGMHLTRHQRTHTGEKPYKCILCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLTSHQRTHTG", "length": 680 }, "evidence": [ { "id": "F1N176", "url": "https://omabrowser.org/oma/group/F1N176/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O14978-1", "protein_name": "Zinc finger protein 263", "gene_name": "ZNF263", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGPGSQEREGLLIVKLEEDCAWSQELPPPDPGPSPEASHLRFRRFRFQEAAGPREALSRLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQRELGRLRQQVTNHGRGTEVLLEEPLPLETARESPSFKLEPMETERSPGPRLQELLGPSPQRDPQAVKERALSAPWLSLFPPEGNMEDKEMTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDSLESHIPSQEVPGTQVGQGGKLWDPSVQSCKEGLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLLPDQARGEVPWSPELGRPHDRSQGDWAPPPEGGMEQALAGASSGRELGRPKELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVDCTEIFGGNPRFLSLHRAHLGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNICGKCFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCPECGKSFSRSSHLVIHERTHERERLYPFSECGEAVSDSTPFLTNHGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTHTGEKPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLMSHQRTHTG", "length": 683 }, "evidence": [ { "id": "F1N176", "url": "https://omabrowser.org/oma/group/F1N176/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CF60-1", "protein_name": "Zinc finger protein 263", "gene_name": "Znf263", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTMAAGPSSQEPEGLLIVKLEEDCAWSHEVPPPEPEPSPEASHLRFRRFRFQDAPGPREALSRLQELCRGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELRPESGEEAVTLVERMQKELGKLRQQVTNQGRGAEVLLEEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPQRDSQAVKERALSAPWLSLFPPEGNVEDKDMTGTQLPESLEDMAMYISQEWDHQDPSKRALSRYMVQDSYENSGTLESSIPSQEVSSTHVEQGEKLWDSSVQTCKEGMNPRNPVPGVEKFENQERNVESVSPESTHPPVLLPGQARREVPWSPEQGRLDDREGHWECPPEDKIEESLVGTPSCKGLVQAKEQPKKLHLCALCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLHRTHIGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPFQCNACGKSFSCNSNLNRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEKERLDPFPECGQGMNDSAPFLTNHRVEKKLFECSTCGKSFRQGMHLTRHQRTHTGEKPYKCILCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLTSHQRTHTG", "length": 680 }, "evidence": [ { "id": "F1N176", "url": "https://omabrowser.org/oma/group/F1N176/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N176", "url": "https://www.uniprot.org/uniprotkb/F1N176" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N176-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 685, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N176-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N176" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 379, "end_pos": 406, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 217, "end_pos": 289, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N176" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 123, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 387, "end_pos": 389 }, { "start_pos": 390, "end_pos": 392 }, { "start_pos": 613, "end_pos": 615 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B9X8-1", "uniprot_ac": "E1B9X8", "uniprot_id": "E1B9X8_BOVIN", "mass": { "chemical_mass": 39373.0, "monoisotopic_mass": 39373.0 }, "refseq": { "ac": "XP_010801104", "name": "SLAM family member 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801104" }, "gene_names": [ { "name": "CD84", "type": "recommended", "evidence": [ { "id": "E1B9X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ] }, { "name": "CD84", "type": "synonym", "evidence": [ { "id": "XP_010801104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801104" } ] } ], "protein_names": [ { "name": "CD84 molecule", "type": "synonym", "evidence": [ { "id": "E1B9X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X8/entry#names_and_taxonomy" } ] }, { "name": "SLAM family member 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010801104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801104" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD84", "url": "https://www.uniprot.org/uniprotkb/E1B9X8", "locus": { "chromosome": "3", "start_pos": 9120525, "end_pos": 9023441, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019033", "url": "https://www.ensembl.org/id/ENSBTAG00000019033" } ] } } ], "crossref": [ { "id": "E1B9X8", "url": "https://alphafold.ebi.ac.uk/entry/E1B9X8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019033", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019033", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16842", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16842", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510910", "url": "https://www.ncbi.nlm.nih.gov/gene/510910", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510910", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510910", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YTYVMVT", "url": "https://omabrowser.org/oma/group/YTYVMVT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9X8", "url": "https://www.orthodb.org/?gene=E1B9X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12080", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12080", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12080:SF103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12080:SF103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010801104", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801104", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RV63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9X8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCCVQKFIVKTMAHHHLWILLFCLQTCLEAAGSDTDIFIVNGILGESATFPLNIQPSQKVTIISWHSKTSVAFVKPGNFGEEPIVTITHQNYHERISVSGQNYNLELRNLRIEDSGIYKADINVETSKVTTTRSYNLQVYRRLEKPKITQSFVTSVNSTCNVTLMCSVDKEEKNVTYSWSPRGEEGNVLQIFQTPDNQEETYTCTAWNPVSNNSDSISAQQLCADITMTPHTRHTGLMSGLAVLSVLIVILPSVVLFLLCKKGEGSFLKNFSKNPDASSKKTIYTYITVSRNTQPAESRIYDEIPQSKVLPTKEEPVNTIYSIMQYSDKMEKTSTQNSKPLGTSSYEIVI", "length": 351, "header": "tr|E1B9X8-1|E1B9X8_BOVIN Isoform 1 of CD84 molecule OS=Bos taurus OX=9913 GN=CD84 PE=4 SV=3 CANONICAL=E1B9X8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RV63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV63/entry", "sequence": { "sequence": "MAHHHLWILLFCLQTCRLEKPKITQSFVTSVNSTCNVTLMCSVDKEEKNVTYSWSPRGEEGNVLQIFQTPDNQEETYTCTAWNPVSNNSDSISAQQLCADITMTPHTRHTGLMSGLAVLSVLIVILPSVVLFLLCKKGEDASSKKTIYTYITVSRNTQPAESRIYDEIPQSKVLPTKEEPVNTIYSIMQYSDKMEKTSTQNSKPLGTSSYEIVI", "length": 214, "header": "tr|A0AAA9RV63-1|E1B9X8_BOVIN Computationally mapped isoform of CD84 molecule OS=Bos taurus OX=9913 GN=CD84 PE=4 SV=1 CANONICAL=E1B9X8-1" }, "locus": { "chromosome": "3", "start_pos": 9119521, "end_pos": 9077402, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121850.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121850.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074960.1" } ] } }, { "isoform_ac": "E1B9X8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9X8/entry", "sequence": { "sequence": "MPCCVQKFIVKTMAHHHLWILLFCLQTCLEAAGSDTDIFIVNGILGESATFPLNIQPSQKVTIISWHSKTSVAFVKPGNFGEEPIVTITHQNYHERISVSGQNYNLELRNLRIEDSGIYKADINVETSKVTTTRSYNLQVYRRLEKPKITQSFVTSVNSTCNVTLMCSVDKEEKNVTYSWSPRGEEGNVLQIFQTPDNQEETYTCTAWNPVSNNSDSISAQQLCADITMTPHTRHTGLMSGLAVLSVLIVILPSVVLFLLCKKGEGSFLKNFSKNPDASSKKTIYTYITVSRNTQPAESRIYDEIPQSKVLPTKEEPVNTIYSIMQYSDKMEKTSTQNSKPLGTSSYEIVI", "length": 351, "header": "tr|E1B9X8-1|E1B9X8_BOVIN Isoform 1 of CD84 molecule OS=Bos taurus OX=9913 GN=CD84 PE=4 SV=3 CANONICAL=E1B9X8-1" }, "locus": { "chromosome": "3", "start_pos": 9119521, "end_pos": 9077366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025333.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025333.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025333.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025333.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510910", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510910", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RJY5-1", "protein_name": "CD84 molecule", "gene_name": "CD84", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHHHTWILLLCLQTRLGAVGSNTDITMVNGILGESVTFSLSILKSEEVKSISWNSKTSVAVVVPGNSGTTITVTHQNYYDRLNVSGLNYNLELRNLRMEDSGIYKADITVKSLEKVTTITKCYDLQVYRRLGKPKITRSLMTSMNGTCNVTLTCSVEKEEKNVTYSWSHLGREGNVLQIFQTPDNQHLTYTCTAWNPVSNNSDSISAQQLCADIAVGLQTRHPGLLSGLAVLSVFIIIIPSVILCLMYKRGQGSYLKTFSKNPDADSKKTIYTYITAAKDAQTAEYRIYDEIPQSKVPPTKEEPVNTIYSIVQYSDKTEKSTQDSKPSGTSSYEIVI", "length": 338 }, "evidence": [ { "id": "E1B9X8", "url": "https://omabrowser.org/oma/group/E1B9X8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q18PI6-1", "protein_name": "SLAM family member 5", "gene_name": "Cd84", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQRHLWIWFLCLQTWSEAAGKDADPMVMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPRHAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEADDVSKKTVYAVVSRNAQPTESRIYDEIPQSKMLSCKEDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV", "length": 329 }, "evidence": [ { "id": "E1B9X8", "url": "https://omabrowser.org/oma/group/E1B9X8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UIB8-1", "protein_name": "SLAM family member 5", "gene_name": "CD84", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQHHLWILLLCLQTWPEAAGKDSEIFTVNGILGESVTFPVNIQEPRQVKIIAWTSKTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTTKRYNLQIYRRLGKPKITQSLMASVNSTCNVTLTCSVEKEEKNVTYNWSPLGEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMGFRTHHTGLLSVLAMFFLLVLILSSVFLFRLFKRRQGRIFPEGSCLNTFTKNPYAASKKTIYTYIMASRNTQPAESRIYDEILQSKVLPSKEEPVNTVYSEVQFADKMGKASTQDSKPPGTSSYEIVI", "length": 345 }, "evidence": [ { "id": "E1B9X8", "url": "https://omabrowser.org/oma/group/E1B9X8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of interleukin-18 production", "id": "GO:0032701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032701", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "regulation of store-operated calcium entry", "id": "GO:2001256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001256", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "negative regulation of granulocyte macrophage colony-stimulating factor production", "id": "GO:0032685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032685", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "negative regulation of mast cell activation", "id": "GO:0033004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033004", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" }, { "name": "negative regulation of mast cell degranulation", "id": "GO:0043305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043305", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1B9X8", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 219, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 213, "end_pos": 215 }, { "start_pos": 271, "end_pos": 273 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0S9-1", "uniprot_ac": "F1N0S9", "uniprot_id": "F1N0S9_BOVIN", "mass": { "chemical_mass": 55330.0, "monoisotopic_mass": 55330.0 }, "refseq": {}, "gene_names": [ { "name": "FAM98A", "type": "recommended", "evidence": [ { "id": "F1N0S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 98 member A", "type": "synonym", "evidence": [ { "id": "F1N0S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM98A", "url": "https://www.uniprot.org/uniprotkb/F1N0S9", "locus": { "chromosome": "11", "start_pos": 16138053, "end_pos": 16153872, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008548", "url": "https://www.ensembl.org/id/ENSBTAG00000008548" } ] } } ], "crossref": [ { "id": "F1N0S9", "url": "https://alphafold.ebi.ac.uk/entry/F1N0S9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008548", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008548", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR018797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TEKQWFA", "url": "https://omabrowser.org/oma/group/TEKQWFA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31353:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31353:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10239", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10239", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0S9-1", "url": "https://www.uniprot.org/uniprotkb/F1N0S9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MECDLMETDILESLEDLGYKGPLLEDGALSQAVTAGASSPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRLLIQKNCLLLLTYLISELEAARMLCVNTLPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAVANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKSTISVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQPAGGRGGGRGGYEHSSYGGRGGHEQQTGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSGGGGGYQDGGYRDSGFQPSGYHGGHSGGYQGGGYGGFQTTTYTGSGYQGGGYQQDNRYQDGGHHGDRGGGRGGRGSRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHSGFGQGRHYTS", "length": 517, "header": "tr|F1N0S9-1|F1N0S9_BOVIN Isoform 1 of Family with sequence similarity 98 member A OS=Bos taurus OX=9913 GN=FAM98A PE=3 SV=3 CANONICAL=F1N0S9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYR3/entry", "sequence": { "sequence": "MECDLMETDILESLEDLGYKGPLLEDGALSQAVTAGASSPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRLLIQKNCLLLLTYLISELEAARMLCVNTLPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAVANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKSTISVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQPAGGRGGGRGGYEHSSYGGRGGHEQQTGGRGNKHQGGWTDGGSGGGGGYQDGGYRDSGFQPSGYHGGHSGGYQGGGYGGFQTTTYTGSGYQGGGYQQDNRYQDGGHHGDRGGGRGGRGSRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHSGFGQGRHYTS", "length": 502, "header": "tr|A0AAA9RYR3-1|F1N0S9_BOVIN Computationally mapped isoform of Family with sequence similarity 98 member A OS=Bos taurus OX=9913 GN=FAM98A PE=3 SV=1 CANONICAL=F1N0S9-1" }, "locus": { "chromosome": "11", "start_pos": 16153844, "end_pos": 16139188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104708.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104708.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078709.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078709.1" } ] } }, { "isoform_ac": "F1N0S9-1", "url": "https://www.uniprot.org/uniprotkb/F1N0S9/entry", "sequence": { "sequence": "MECDLMETDILESLEDLGYKGPLLEDGALSQAVTAGASSPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRLLIQKNCLLLLTYLISELEAARMLCVNTLPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAVANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKSTISVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQPAGGRGGGRGGYEHSSYGGRGGHEQQTGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSGGGGGYQDGGYRDSGFQPSGYHGGHSGGYQGGGYGGFQTTTYTGSGYQGGGYQQDNRYQDGGHHGDRGGGRGGRGSRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHSGFGQGRHYTS", "length": 517, "header": "tr|F1N0S9-1|F1N0S9_BOVIN Isoform 1 of Family with sequence similarity 98 member A OS=Bos taurus OX=9913 GN=FAM98A PE=3 SV=3 CANONICAL=F1N0S9-1" }, "locus": { "chromosome": "11", "start_pos": 16153844, "end_pos": 16139188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011270.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011270.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011270.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011270.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 34, "start_aa": "Thr", "end_pos": 34, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr34", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q3TJZ6-1", "protein_name": "Protein FAM98A", "gene_name": "Fam98a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MECDLMETDILESLEDLGYKGPLLDDGALLQAVSAGAASPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYPSLTSGDVTKRLLVEKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAIANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTDKLAKVYQPKRSLLSPKGKVSVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQQAGGRGGGRGGYEHSSYGGRGGHEQGGRGGRGSYDHGGRGGGRGNKHQGGWTDGGSGSGGGYQDGAYRDSGFQPGGYHGGHSGGYQAGGYGGFQTSSYTGSGYQGGGYQQDNRYQDGGHHGERGSGRGGRGGRGGRGGRGSQGGGWGGRGSQTYHQGGQFEQHFQHGGYQYSHSGFGQGRHYTS", "length": 515 }, "evidence": [ { "id": "F1N0S9", "url": "https://omabrowser.org/oma/group/F1N0S9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5FWT1-1", "protein_name": "Protein FAM98A", "gene_name": "Fam98a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MECDLMETDILESLEDLGYKGPLLDDGALLQAVSAGAASPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYPCLTSGDVTKRLLVQKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKSMGPAHWEKIEAINQAIANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKGNISIAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQQAGGRGGGRGGYEHSSYGGRGGHEQGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSASGGGYQDGGYRDPGFQPGGYHGGHSSGYQGGGYGGFQTSSYTGSGYQGGGYQQDNRYQDGGHHGERGSGRGGRGGRGGRGGRGSQGGGWGGRGSQTYHQGGQFEQHFQHGGYQYSHSGFGQGRHYTS", "length": 515 }, "evidence": [ { "id": "F1N0S9", "url": "https://omabrowser.org/oma/group/F1N0S9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NCA5-1", "protein_name": "Protein FAM98A", "gene_name": "FAM98A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MECDLMETDILESLEDLGYKGPLLEDGALSQAVSAGASSPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRLLIQKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAIANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKTTISVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQQTGGRGGGRGGYEHSSYGGRGGHEQGGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSGGGGGYQDGGYRDSGFQPGGYHGGHSSGGYQGGGYGGFQTSSSYTGSGYQGGGYQQDNRYQDGGHHGDRGGGRGGRGGRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHSGFGQGRHYTS", "length": 518 }, "evidence": [ { "id": "F1N0S9", "url": "https://omabrowser.org/oma/group/F1N0S9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X1WEE6-1", "protein_name": "Protein FAM98A", "gene_name": "fam98a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEVTDILDSLEDLGYQGPLLEDGTLETAVTGGAESPEFTKLCAWLVSELKLYCKLEENVQATNCPSEAEGFQLEMSGLLAELCCPYPALTTGEVTKRLLNANNCVLLLSFLISELESSRMIVVNQPQKKVQETGGSKVFMELKGICMALGMSKPPSNITMFQFFSGIEKKLKEALAKVPPSHIGEPLMKKPLGPVHWEKIEAINQALENEYEVRRKMLLKRLDVTVQSFGWSERAKTHADKLSKVYQPLRVALATKTRVSVAHLFAAREDLSKILRTSSGHTREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPTWQKRQDGPQGGGGGGQYYSGGGRGGGRGGYDQQQGGRGGHDRGGGGGGRGGRGDHRGGKAQGNWQDGYQGHYQDGGYRGGYGGGGGSGGGGYHGAQQGSGYQGGGYQGVQQGPGYQGGGGGGGYQGGGGGYQHEGYYQDGGRHQERGGRGGRGGRGRGGGGGGRGTGQGGGWGGRGGQNFNQGGQFEQFFQQGGHQYSQAGFGQGRQFTS", "length": 527 }, "evidence": [ { "id": "F1N0S9", "url": "https://omabrowser.org/oma/group/F1N0S9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "pmid": "" }, { "name": "positive regulation of ruffle assembly", "id": "GO:1900029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900029", "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein methyltransferase activity", "id": "GO:0008276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008276", "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "tRNA-splicing ligase complex", "id": "GO:0072669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072669", "evidence": [ { "database": "UniProtKB", "id": "F1N0S9", "url": "https://www.uniprot.org/uniprotkb/F1N0S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0S9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 517, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0S9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0S9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 34 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 505, "end_pos": 507 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MZY9-1", "uniprot_ac": "F1MZY9", "uniprot_id": "F1MZY9_BOVIN", "mass": { "chemical_mass": 51375.0, "monoisotopic_mass": 51375.0 }, "refseq": {}, "gene_names": [ { "name": "SLC2A8", "type": "recommended", "evidence": [ { "id": "F1MZY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ] } ], "protein_names": [ { "name": "Solute carrier family 2, facilitated glucose transporter member 8", "type": "recommended", "evidence": [ { "id": "F1MZY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZY9/entry#names_and_taxonomy" } ] }, { "name": "Glucose transporter type 8", "type": "synonym", "evidence": [ { "id": "F1MZY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZY9/entry#names_and_taxonomy" } ] }, { "name": "Glucose transporter type X1", "type": "synonym", "evidence": [ { "id": "F1MZY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZY9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate.", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9#function" }, { "database": "UniProtKB", "id": "ARBA00059062", "url": "https://www.uniprot.org/uniprotkb/ARBA00059062#function" }, { "database": "UniProtKB", "id": "A0AAA9RZP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP4#function" }, { "database": "UniProtKB", "id": "A0AAA9SUE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC2A8", "url": "https://www.uniprot.org/uniprotkb/F1MZY9", "locus": { "chromosome": "11", "start_pos": 98159560, "end_pos": 98149418, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006957", "url": "https://www.ensembl.org/id/ENSBTAG00000006957" } ] } } ], "crossref": [ { "id": "F1MZY9", "url": "https://alphafold.ebi.ac.uk/entry/F1MZY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006957", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006957", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YWIDYGT", "url": "https://omabrowser.org/oma/group/YWIDYGT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MZY9", "url": "https://www.orthodb.org/?gene=F1MZY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48021", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48021", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48021:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48021:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "17629", "url": "https://www.rhea-db.org/rhea/17629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60372", "url": "https://www.rhea-db.org/rhea/60372", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60376", "url": "https://www.rhea-db.org/rhea/60376", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60380", "url": "https://www.rhea-db.org/rhea/60380", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MZY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPEDQEETQPLLRPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLRRAAPPAPHLDEDAASWFGAIVTLGAAAGGVLGGWLLDRAGRKLSLVLCALPFVAGFAVITAAQNLWMLLGGRLLTGLACGIASLVAPVYISEIAYPEVRGLLGSCVQLMVVTGILLAYLAGWVLEWRWLAVLGCVAPSFMLLLMCFMPETPRFLLSQHKHQEAMAAMQFLWGYAQGWEEPPLGAQHQDFHVAQLRRPGVYKPFIIGISLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTATAALIMDRAGRRLLLTLSGVVMVFSTSAFGAYFKLTEGGPSNSSHVDLPALISMEAADTNVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGVCVLTNWFMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFGVLFTLACVPETKGKTLEQITAHFEGR", "length": 478, "header": "tr|F1MZY9-1|F1MZY9_BOVIN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus OX=9913 GN=SLC2A8 PE=3 SV=2 CANONICAL=F1MZY9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP4/entry", "sequence": { "sequence": "MTPEDQEETQPLLRPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLRRAAPPAPHLDEDAASWFGAIVTLGAAAGGVLGGWLLDRAGRKLSLVLCALPFVAGFAVITAAQNLWMLLGGRLLTGLACGIASLVAPVYISEIAYPEVRGLLGSCVQLMVVTGILLAYLAGWVLEWRWLAVLGCVAPSFMLLLMCFMPETPRFLLSQHKHQEAMAAMQFLWGYAQGWEEPPLGAQHQDFHVAQLRRPGVYKPFIIGISLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTATAALIMDRAGRRLLLTLSGVVMVFSTSAFGAYFKLTEGGPSNSSHVDLPALISMEAADTNVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGVCVLTNWFMAFLVTKEFSSLMQPLIATSTFLQYQGLWTHALFRGPLTFLEAFP", "length": 465, "header": "tr|A0AAA9RZP4-1|F1MZY9_BOVIN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus OX=9913 GN=SLC2A8 PE=3 SV=1 CANONICAL=F1MZY9-1" }, "locus": { "chromosome": "11", "start_pos": 98159549, "end_pos": 98149513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124370.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124370.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076559.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076559.1" } ] } }, { "isoform_ac": "A0AAA9SUE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUE9/entry", "sequence": { "sequence": "MTPEDQEETQPLLRPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLRRAAPPAPHLDEDAASWFGAIVTLGAAAGGVLGGWLLDRAGRKLSLVLCALPFVAGFAVITAAQNLWMLLGGRLLTGLACGIASLVAPVYISEIAYPEVRGLLGSCVQLMVVTGILLAYLAGWVLEWRWLAVLGCVAPSFMLLLMCFMPETPRFLLSQHKHQEAMAAMQFLWGYAQGWEEPPLGAQHQDFHVAQLRRPGVYKPFIIGISLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTATAALIMDRAGRRLLLTLSGVVMVFSTSAFGAYFKLTEGGPSNSSHVDLPALISMEAADTNVGLAWLAVGSMCLFIAGGAQALRCLLAGLCLLHLRCPFHSGLCP", "length": 412, "header": "tr|A0AAA9SUE9-1|F1MZY9_BOVIN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus OX=9913 GN=SLC2A8 PE=3 SV=1 CANONICAL=F1MZY9-1" }, "locus": { "chromosome": "11", "start_pos": 98157924, "end_pos": 98149513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119866.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119866.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088961.1" } ] } }, { "isoform_ac": "F1MZY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MZY9/entry", "sequence": { "sequence": "MTPEDQEETQPLLRPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLRRAAPPAPHLDEDAASWFGAIVTLGAAAGGVLGGWLLDRAGRKLSLVLCALPFVAGFAVITAAQNLWMLLGGRLLTGLACGIASLVAPVYISEIAYPEVRGLLGSCVQLMVVTGILLAYLAGWVLEWRWLAVLGCVAPSFMLLLMCFMPETPRFLLSQHKHQEAMAAMQFLWGYAQGWEEPPLGAQHQDFHVAQLRRPGVYKPFIIGISLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTATAALIMDRAGRRLLLTLSGVVMVFSTSAFGAYFKLTEGGPSNSSHVDLPALISMEAADTNVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGVCVLTNWFMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFGVLFTLACVPETKGKTLEQITAHFEGR", "length": 478, "header": "tr|F1MZY9-1|F1MZY9_BOVIN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus OX=9913 GN=SLC2A8 PE=3 SV=2 CANONICAL=F1MZY9-1" }, "locus": { "chromosome": "11", "start_pos": 98157976, "end_pos": 98149513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009144.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009144.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009144.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009144.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-189200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "resource": "Reactome", "description": "Cellular hexose transport" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480HHY7-1", "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "SLC2A8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTPEFPEDSQPLLRPLGESAPRSRRVFLAAFAAALGPLSFGFVLGYSSPAIPSLRRAAPPAPRLDNDATSWFGAIVTLGAAVGGVLGGWLVDRAGRKLSLLLCTVPFVAGFAIITAAQNVWMLLGGRLLTGLACGVASLVAPVYISEIAYPEVRGLLGSCVQLMVVTGILLAYLAGWVLEWRWLAVLGSVPPTFMLLLMGCMPETPRFLLTQHKHQEAMAAMQFLWGSEQRWEEPPVGAEHQGFRLAQLRRPGVYKPFVIGVSLMIFQQLSGINAVMFYAETIFEEAKFKESSLASVIVGVIQVLFTAVAALVMDRAGRRVLLTLSGVVMVFSTSAFGTYFKLTQDGPSNSSHVHLLAPVSVEPTDASVGLAWLAVGSVCLFIAGFALGWGPIPWLLMSEIFPLHVKGVATGVCVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLACVPETKGKTLEQITAHFEGR", "length": 478 }, "evidence": [ { "id": "F1MZY9", "url": "https://omabrowser.org/oma/group/F1MZY9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NDA6-1", "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "SLC2A8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAEESQYLLAHRTSDAYLRVQNKKLYLATFAAVLGPLSFGFVLGYSSPAIPELRKIDNPKLRLDSNQASWFGSIVTLGAAAGGILGGYLVDKIGRKLSLMLCSIPFVSGYIVIISAQNVWMLYFGRILTGLASGITSLVVPVYISEISHTDVRGMLGSFVQLMVVTGILGAYIAGLTLKWHWLAVLCSFPPCVMLLFMLFMPETPRFLLDQKKRAEAIAALQFLRGPYVDHEWECRQIEANVEEEGLSLFEFKNPSIYRPLLIGVILMFLQQVTGINAVMFYAETIFEDANFQDSRMASVVVGFIQVCFTAVAALIIDKTGRKVLLYVSGMIMALSTALFGFYFKMVLPNGNNSSNTDLWFTLNSVTPGTDTRLSWLAVVSLGLFVAGFALGWGPVPWLVMSEIFPLKARGVSSSACVLTNWVMAFLVTKEFHDFIGFLTSYGTFWLFSAFCCLSVTFAAFYVPETKGRTLEQIEAYFRKS", "length": 482 }, "evidence": [ { "id": "F1MZY9", "url": "https://omabrowser.org/oma/group/F1MZY9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q54UC8-1", "protein_name": "Sugar transporter family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVVNKKTSKEVNIYDNVVFEDIGEFASKKKKQDRFKHINARNPLVKTWKPLWLIRLGSSTGLIITLSASGGLIFGYNTGIIGPALGHINNEYHLNTILQGLIVCSTLLGALIGSVSGGFLADWIGRKTVVLLTAIVTIGGAISSSATNPLSLVASLRIILGLGVGMSSGVCPLMVAEVVPVEKRGVYGSVFQLFITLGLLWSNVMGLLLIESGIHNWRWMFAIGSLPGFFMLLCWTVLNESPVWVENQRLKKERKLQESAISNSKPKKSSFRILMEKKNRRPLFIGVILATFQQLTGINAFMYFSNLIFFKAGFTGEYGAITCSCILQLWNVSFTIIAACTVDRLGRRPLLFIGSIVMTCADLLIALFYVALTGKVQGWLSIICLFIFVAAFAMSIGTLFWFIVNEIFDPEAKDIGAPILIGLQWLFNMLLSLTFVGAVPYIGDSTMFWIFGGIGITCVVLLAIFLPPEKIQQSELESDVLPDSFKQAATVYNDEVELSPSEKKNNFYIPNEDAEEILENLSELPSENMEIPRNIEN", "length": 537 }, "evidence": [ { "id": "F1MZY9", "url": "https://omabrowser.org/oma/group/F1MZY9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9FRL3-1", "protein_name": "Sugar transporter ERD6-like 6", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSFRDDNEEARNDLRRPFIHTGSWYRMGSRQSSMMGSSQVIRDSSISVLACVLIVALGPIQFGFTCGYSSPTQAAITKDLGLTVSEYSVFGSLSNVGAMVGAIASGQIAEYIGRKGSLMIAAIPNIIGWLCISFAKDTSFLYMGRLLEGFGVGIISYTVPVYIAEIAPQNMRGGLGSVNQLSVTIGIMLAYLLGLFVPWRILAVLGILPCTLLIPGLFFIPESPRWLAKMGMTDEFETSLQVLRGFETDITVEVNEIKRSVASSTKRNTVRFVDLKRRRYYFPLMVGIGLLVLQQLGGINGVLFYSSTIFESAGVTSSNAATFGVGAIQVVATAISTWLVDKAGRRLLLTISSVGMTISLVIVAAAFYLKEFVSPDSDMYSWLSILSVVGVVAMVVFFSLGMGPIPWLIMSEILPVNIKGLAGSIATLANWFFSWLITMTANLLLAWSSGGTFTLYGLVCAFTVVFVTLWVPETKGKTLEELQSLFR", "length": 487 }, "evidence": [ { "id": "F1MZY9", "url": "https://omabrowser.org/oma/group/F1MZY9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JJZ1-1", "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "Slc2a8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHKPLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITAHFEGR", "length": 478 }, "evidence": [ { "id": "F1MZY9", "url": "https://omabrowser.org/oma/group/F1MZY9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NY64-1", "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "SLC2A8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR", "length": 477 }, "evidence": [ { "id": "F1MZY9", "url": "https://omabrowser.org/oma/group/F1MZY9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "dehydroascorbic acid transmembrane transporter activity", "id": "GO:0033300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033300", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" }, { "name": "fructose transmembrane transporter activity", "id": "GO:0005353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005353", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" }, { "name": "D-glucose binding", "id": "GO:0005536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005536", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" }, { "name": "D-glucose transmembrane transporter activity", "id": "GO:0055056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055056", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "D-glucose transmembrane transport", "id": "GO:1904659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904659", "evidence": [ { "database": "UniProtKB", "id": "F1MZY9", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17629", "name": "", "equation": "alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "17629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17629" } ] }, { "id": "60372", "name": "", "equation": "D-fructose(out) = D-fructose(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "60372", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60372" } ] }, { "id": "60376", "name": "", "equation": "D-glucose(out) = D-glucose(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "60376", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60376" } ] }, { "id": "60380", "name": "", "equation": "L-dehydroascorbate(out) = L-dehydroascorbate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "60380", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60380" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MZY9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 478, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MZY9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MZY9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MZY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZY9" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 464, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 350, "end_pos": 352 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0M1-1", "uniprot_ac": "F1N0M1", "uniprot_id": "F1N0M1_BOVIN", "mass": { "chemical_mass": 42681.0, "monoisotopic_mass": 42681.0 }, "refseq": { "ac": "XP_002686497", "name": "N-acetylaspartylglutamate synthase A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686497" }, "gene_names": [ { "name": "RIMKLA", "type": "recommended", "evidence": [ { "id": "F1N0M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ] }, { "name": "RIMKLA", "type": "synonym", "evidence": [ { "id": "XP_002686497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686497" } ] } ], "protein_names": [ { "name": "N-acetylaspartylglutamate synthase", "type": "recommended", "evidence": [ { "id": "F1N0M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M1/entry#names_and_taxonomy" } ] }, { "name": "6.3.2.41", "type": "synonym", "evidence": [ { "id": "F1N0M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M1/entry#names_and_taxonomy" } ] }, { "name": "N-acetylaspartylglutamate synthase A", "type": "synonym", "evidence": [ { "id": "XP_002686497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686497" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0M1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIMKLA", "url": "https://www.uniprot.org/uniprotkb/F1N0M1", "locus": { "chromosome": "3", "start_pos": 103774475, "end_pos": 103824922, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017502", "url": "https://www.ensembl.org/id/ENSBTAG00000017502" } ] } } ], "crossref": [ { "id": "F1N0M1", "url": "https://alphafold.ebi.ac.uk/entry/F1N0M1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017502", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017502", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507323", "url": "https://www.ncbi.nlm.nih.gov/gene/507323", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507323", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507323", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKHGVMV", "url": "https://omabrowser.org/oma/group/EKHGVMV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0M1", "url": "https://www.orthodb.org/?gene=F1N0M1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21621", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21621", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21621:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21621:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8964539", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964539", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002686497", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686497", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "40035", "url": "https://www.rhea-db.org/rhea/40035", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0M1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0M1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCSQLWFLTDRRIREDYPQVQILRALRQRCSEQDVRFRAVLMDQIAVTIVGGNLGLQLNQKALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKGVFLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVMCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGGIIADYTMSLLPNRQTGKMAVLPGLASPREKKEPDGCASAQGVAESVYAINSGSTSSESEPELGEIRASSASTAGAPAPMLPDPSYNINTRIASELKLK", "length": 391, "header": "tr|F1N0M1-1|F1N0M1_BOVIN Isoform 1 of N-acetylaspartylglutamate synthase OS=Bos taurus OX=9913 GN=RIMKLA PE=3 SV=3 CANONICAL=F1N0M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZZ7/entry", "sequence": { "sequence": "MPLPVSDCTLRCASGEDFQGKNSNQIHNSRAGLQLNQKALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKGVFLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVMCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGGIIADYTMSLLPNRQTGKMAVLPGLASPREKKEPDGCASAQGVAESVYAINSGSTSSESEPELGEIRASSASTAGAPAPMLPDPSYNINTRIASELKLK", "length": 368, "header": "tr|A0AAA9RZZ7-1|F1N0M1_BOVIN Computationally mapped isoform of N-acetylaspartylglutamate synthase OS=Bos taurus OX=9913 GN=RIMKLA PE=3 SV=1 CANONICAL=F1N0M1-1" }, "locus": { "chromosome": "3", "start_pos": 103824621, "end_pos": 103775479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106646.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106646.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075390.1" } ] } }, { "isoform_ac": "F1N0M1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1/entry", "sequence": { "sequence": "MCSQLWFLTDRRIREDYPQVQILRALRQRCSEQDVRFRAVLMDQIAVTIVGGNLGLQLNQKALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKGVFLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVMCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGGIIADYTMSLLPNRQTGKMAVLPGLASPREKKEPDGCASAQGVAESVYAINSGSTSSESEPELGEIRASSASTAGAPAPMLPDPSYNINTRIASELKLK", "length": 391, "header": "tr|F1N0M1-1|F1N0M1_BOVIN Isoform 1 of N-acetylaspartylglutamate synthase OS=Bos taurus OX=9913 GN=RIMKLA PE=3 SV=3 CANONICAL=F1N0M1-1" }, "locus": { "chromosome": "3", "start_pos": 103807550, "end_pos": 103775479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023262.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023262.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023262.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023262.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:507323", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507323", "resource": "KEGG Pathway" }, { "id": "R-BTA-8964539", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964539", "resource": "Reactome", "description": "Glutamate and glutamine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A7C3-1", "protein_name": "N-acetylaspartylglutamate synthase", "gene_name": "Rimkla", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCAQVWLLTDRLIREDYPQVQILRALRQRCSEQDVGFRAVFLDQIAVTVVGGHLGLQLSQKPLTTFPDVVVVRVSTPSVQSDSEITILRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDICHLVRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCFLGGVGVKCSLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFMVCEANANVGFLAFDQACNLDVGAIIADYAMSLLPNRQTGKMAILPGLASPREKSEPNGCVSAQGVAESVYTITNGSTSSESEPELGEARDSSAKTMGAPPAHVTRAWLQH", "length": 380 }, "evidence": [ { "id": "F1N0M1", "url": "https://omabrowser.org/oma/group/F1N0M1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SF91-1", "protein_name": "N-acetylaspartylglutamate synthase", "gene_name": "RIMKLA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCSQLWFLTDRRIREDYPQVQILRALRQRCSEQDVRFRAVLMDQIAVTIVGGNLGLQLNQKALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDVCHLVRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVMCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGSIIADYTMTLLPSRPTGHMAVLPGLSGPREQKEPDGCGSAQGIGAESGYAVNSGSTSSESEPELGESRASAAGSAGAPAPVLPEPGYNMNTRIAAELKLK", "length": 392 }, "evidence": [ { "id": "F1N0M1", "url": "https://omabrowser.org/oma/group/F1N0M1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PFX8-1", "protein_name": "N-acetylaspartylglutamate synthase A", "gene_name": "Rimkla", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCAQVWLLTDRLIREDYPQVQILRALRQRCSEQDVGFRAVFLDQIAVTVVGGHLGLQLSQKPLTTFPDVVVVRVSTPSVQSDSEITILRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDICHLVRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCFLGGVGVKCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFTVCEANANVGFLAFDQACNLDVGAIIADYAMSLLPNRQTGKMAILPGLASPREKNEPNGCVSAQGVAESVYAITNGSTSSESEPELGEARDSSVKTMGAPPAHVAQAWLQH", "length": 380 }, "evidence": [ { "id": "F1N0M1", "url": "https://omabrowser.org/oma/group/F1N0M1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IXN7-1", "protein_name": "N-acetylaspartylglutamate synthase A", "gene_name": "RIMKLA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCSQLWFLTDRRIREDYPQVQILRALRQRCSEQDVRFRAVLMDQIAVTIVGGHLGLQLNQKALTTFPDVVLVRVPTPSVQSDSDITVLRHLEKLGCRLVNRPQSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQSNCSLGGVGVKCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFVVCEANANVGFLAFDQACNLDVGGIIADYTMSLLPNRQTGKMAVLPGLSSPREKNEPDGCASAQGVAESVYTINSGSTSSESEPELGEIRDSSASTMGAPPSMLPEPGYNINNRIASELKLK", "length": 391 }, "evidence": [ { "id": "F1N0M1", "url": "https://omabrowser.org/oma/group/F1N0M1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N0M1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N0M1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ], "pmid": "" }, { "name": "N-acetyl-L-aspartate-L-glutamate ligase activity", "id": "GO:0072590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072590", "evidence": [ { "database": "UniProtKB", "id": "F1N0M1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0M1", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "40035", "name": "", "equation": "N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0M1-1", "Q0VCE9-1" ], "evidence": [ { "id": "40035", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40035" } ] }, { "id": "R-BTA-8942575", "name": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-5693772" ], "output_participant_list": [ "R-ALL-5693762" ], "enzyme_list": [ "Q0VCE9-1", "F1N0M1-1" ], "evidence": [ { "id": "R-BTA-8942575", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8942575" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5693762", "participant_name": "NAAG [cytosol]", "crossref": [ { "id": "ZINC000001532510", "database": "ZINC", "url": "" }, { "id": "76931", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5693772", "participant_name": "NAASP [cytosol]", "crossref": [ { "id": "16953", "database": "ChEBI", "url": "" }, { "id": "C01042", "database": "COMPOUND", "url": "" }, { "id": "ZINC000002446417", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1N0M1", "gene_name": "RIMKLA", "activity": [ { "ec_number": "6.3.2.41", "activity": "N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+).", "evidence": [ { "id": "F1N0M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ] }, { "ec_number": "6.3.2.41", "activity": "", "evidence": [ { "id": "F1N0M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" } ] } ] }, { "uniprot_ac": "Q0VCE9", "gene_name": "RIMKLB", "activity": [ { "ec_number": "6.3.1.17", "activity": "citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCE9" } ] }, { "ec_number": "6.3.2.41", "activity": "N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCE9" } ] }, { "ec_number": "6.3.1.17", "activity": "", "evidence": [ { "id": "Q0VCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCE9" } ] }, { "ec_number": "6.3.2.41", "activity": "", "evidence": [ { "id": "Q0VCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCE9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0M1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 391, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0M1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0M1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0M1" }, { "id": "PS50975", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50975" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ATP-grasp", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 300, "start_aa": "Phe", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.2.41", "ec_name": "N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+).", "evidence": [ { "id": "6.3.2.41", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41" }, { "id": "6.3.2.41", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.2.41" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N099-1", "uniprot_ac": "F1N099", "uniprot_id": "F1N099_BOVIN", "mass": { "chemical_mass": 167665.0, "monoisotopic_mass": 167665.0 }, "refseq": { "ac": "XP_005206671", "name": "bridge-like lipid transfer protein family member 3B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206671" }, "gene_names": [ { "name": "BLTP3B", "type": "recommended", "evidence": [ { "id": "F1N099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ] }, { "name": "BLTP3B", "type": "synonym", "evidence": [ { "id": "XP_005206671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206671" } ] }, { "name": "UHRF1BP1L", "type": "synonym", "evidence": [ { "id": "XP_005206671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206671" } ] } ], "protein_names": [ { "name": "Bridge-like lipid transfer protein family member 3B", "type": "synonym", "evidence": [ { "id": "F1N099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N099/entry#names_and_taxonomy" } ] }, { "name": "bridge-like lipid transfer protein family member 3B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005206671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206671" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BLTP3B", "url": "https://www.uniprot.org/uniprotkb/F1N099", "locus": { "chromosome": "5", "start_pos": 64074489, "end_pos": 64165273, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006040", "url": "https://www.ensembl.org/id/ENSBTAG00000006040" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006040", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006040", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520720", "url": "https://www.ncbi.nlm.nih.gov/gene/520720", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N099", "url": "https://www.orthodb.org/?gene=F1N099", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22774:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22774:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24917", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24917", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005206671", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206671", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N099-1", "url": "https://www.uniprot.org/uniprotkb/F1N099-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRNPNGPSPIATASGQSEYGFAEKVVEGITVSVNSIVIRIGAKAFNASFELSQLRIYSVNANWEHGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMFAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAPEPTQSSAVAPSTQHAKTPQTSNAPDLSDAIVKLFSDFDVKETSHHLVVSHLDLHICDDIHAKEKESNRRITGGAMQLSFTQLTIDYYPYHKAGDSCNHWMYFSDATKTKNGWANELLHEFECNVEMLKQAVKDHNVGSPPKSPTHASPQHTQTEKDSALKGASKKPSALSQQSKVKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMISCNKKSLYLPQEMSAVYIEFTEYYYPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFVLDLKQSLNQFMAVYKLNDNSKSDEHVDIRVDGLMLKVPYKQVAVRIKPFLQKKSYQHCNFQDLRWFVIPSEMKSECHQDQPRAISIQSSEMIATNTRHCPNCRHSDLEALFQDFKDCDFFSKTYTSFPKSGDNFNLLHPIFQRHAHEQDTKLHEVYKGNVTPKLNKHTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPINFVDSFPLSIWICQPKRYAVSQKSLQTCNQISLNTSQSESSDLTGRWKRKKLLKEYYSTECDPLTSGGQKPSSDTFLRFSSPSSDADIHVLVHVRKHVSMQINHYQYLLLLFLHESLILLSENLRKDVEAVTGSPASQTSVCIGILLKSAEVALLLHPVDQANTLKSPVSESVSPMVPDYLPAENGEFLPSKRKHVSSGINQIRSVTLNHMSDNRSMSVDLSHVPVKDSLLFKSASDTNLQKDISSLNYLSDKNLGKISEVESSGLVSQSGSGEIGSETSGKKVSSYTDSNSVLNYREDSSILSFDDGGNQNILSNSLTSKRSETIESIFKAEDLLPETASLSENVEISKEEAPTIRTLKSQSSLSGKPKERCLPTLAPVSTYKNMRRSPSQTSLDTISLDSMILEEQLLESDGSDSHIFLEKGIKKNSTTNYQSPADQTNASANLQNYGETSPDAISTNSEGAQESHDDLMSIVVFKITGVNGEIDIRGEDTEICLQVDQVIPDQLGNISLRHYLSHRPVGSDHKAVIHSKSSPEITLRFESGPGAVIHSLLAEKNGFLQCHIENFSTEFLVSSLMNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRSSTISLEPAPVTVHIDHLVVERNDDGSFHIRDSQILNTRNDLEENVKSDSVLHTSGTCDLKKKHSVTQATQTSPEVPWPLQSANFPECSFDFTREQLMEENESLKQELAKAKMALAEAHLEKDALLHQLNIRSGSQKLKL", "length": 1496, "header": "tr|F1N099-1|F1N099_BOVIN Isoform 1 of Bridge-like lipid transfer protein family member 3B OS=Bos taurus OX=9913 GN=BLTP3B PE=4 SV=4 CANONICAL=F1N099-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S3/entry", "sequence": { "sequence": "MAGLIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRNPNGPSPIATASGQSEYGFAEKVVEGITVSVNSIVIRIGAKAFNASFELSQLRIYSVNANWEHGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMFAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAPEPTQSSAVAPSTQHAKTPQTSNAPDLSDAIVKLFSDFDVKETSHHLVVSHLDLHICDDIHAKEKESNRRITGGAMQLSFTQLTIDYYPYHKAGDSCNHWMYFSDATKTKNGWANELLHEFECNVEMLKQAVKDHNVGSPPKSPTHASPQHTQTEKDSALKGASKKPSALSQQSKVKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMISCNKKSLYLPQEMSAVYIEFTEYYYPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFVLDLKQSLNQFMAVYKLNDNSKSDEHVDIRVDGLMLKFVIPSEMKSECHQDQPRAISIQSSEMIATNTRHCPNCRHSDLEALFQDFKDCDFFSKTYTSFPKSGDNFNLLHPIFQRHAHEQDTKLHEVYKGNVTPKLNKHTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPINFVDSFPLSIWICQPKRYAVSQKSLQTCNQISLNTSQSESSDLTGRWKRKKLLKEYYSTECDPLTSGGQKPSSDTFLRFSSPSSDADIHVLVHVRKHVSMQINHYQYLLLLFLHESLILLSENLRKDVEAVTGSPASQTSVCIGILLKSAEVALLLHPVDQANTLKSPVSESVSPMVPDYLPAENGEFLPSKRKHVSSGINQIRSVTLNHMSDNRSMSVDLSHVPVKDSLLFKSASDTNLQKDISSLNYLSDKNLGKISEVESSGLVSQSGSGEIGSETSGKKVSSYTDSNSVLNYREDSSILSFDDGGNQNILSNSLTSKRSETIESIFKAEDLLPETASLSENVEISKEEAPTIRTLKSQSSLSGKPKERCLPTLAPVSTYKNMRRSPSQTSLDTISLDSMILEEQLLESDGSDSHIFLEKGIKKNSTTNYQSPADQTNASANLQNYGETSPDAISTNSEGAQESHDDLMSIVVFKITGVNGEIDIRGEDTEICLQVDQVIPDQLGNISLRHYLSHRPVGSDHKAVIHSKSSPEITLRFESGPGAVIHSLLAEKNGFLQCHIENFSTEFLVSSLMNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRSSTISLEPAPVTVHIDHLVVERNDDGSFHIREVTFAII", "length": 1365, "header": "tr|A0AAA9S6S3-1|F1N099_BOVIN Computationally mapped isoform of Bridge-like lipid transfer protein family member 3B OS=Bos taurus OX=9913 GN=BLTP3B PE=4 SV=1 CANONICAL=F1N099-1" }, "locus": { "chromosome": "5", "start_pos": 64165062, "end_pos": 64079214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119651.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119651.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080880.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080880.1" } ] } }, { "isoform_ac": "A0AAA9SM04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM04/entry", "sequence": { "sequence": "MAGLIKKQILKHLSRLNVGSCFQVVNSEFRMRDYDPFLCYLFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRNPNGPSPIATASGQSEYGFAEKVVEGITVSVNSIVIRIGAKAFNASFELSQLRIYSVNANWEHGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMFAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAPEPTQSSAVAPSTQHAKTPQTSNAPDLSDAIVKLFSDFDVKETSHHLVVSHLDLHICDDIHAKEKESNRRITGGAMQLSFTQLTIDYYPYHKAGDSCNHWMYFSDATKTKNGWANELLHEFECNVEMLKQAVKDHNVGSPPKSPTHASPQHTQTEKDSALKGASKKPSALSQQSKVKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMISCNKKSLYLPQEMSAVYIEFTEYYYPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFVLDLKQSLNQFMAVYKLNDNSKSDEHVDIRVDGLMLKFVIPSEMKSECHQDQPRAISIQSSEMIATNTRHCPNCRHSDLEALFQDFKDCDFFSKTYTSFPKSGDNFNLLHPIFQRHAHEQDTKLHEVYKGNVTPKLNKHTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPINFVDSFPLSIWICQPKRYAVSQKSLQTCNQISLNTSQSESSDLTGRWKRKKLLKEYYSTECDPLTSGGQKPSSDTFLRFSSPSSDADIHVLVHVRKHVSMQINHYQYLLLLFLHESLILLSENLRKDVEAVTGSPASQTSVCIGILLKSAEVALLLHPVDQANTLKSPVSESVSPMVPDYLPAENGEFLPSKRKHVSSGINQIRSVTLNHMSDNRSMSVDLSHVPVKDSLLFKSASDTNLQKDISSLNYLSDKNLGKISEVESSGLVSQSGSGEIGSETSGKKVSSYTDSNSVLNYREDSSILSFDDGGNQNILSNSLTSKRSETIESIFKAEDLLPETASLSENVEISKEEAPTIRTLKSQSSLSGKPKERCLPTLAPVSTYKNMRRSPSQTSLDTISLDSMILEEQLLESDGSDSHIFLEKGIKKNSTTNYQSPADQTNASANLQNYGETSPDAISTNSEGAQESHDDLMSIVVFKITGVNGEIDIRGEDTEICLQVDQVIPDQLGNISLRHYLSHRPVGSDHKAVIHSKSSPEITLRFESGPGAVIHSLLAEKNGFLQCHIENFSTEFLVSSLMNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRSSTISLEPAPVTVHIDHLVVERNDDGSFHIRDSQILNTRNDLEENVKSDSVLHTSGTCDLKKKHSVTQATQTSPEVPWPLQSANFPECSFDFTREQLMEENESLKQELAKAKMALAEAHLEKDALLHQLNIRSGSQKLKL", "length": 1493, "header": "tr|A0AAA9SM04-1|F1N099_BOVIN Computationally mapped isoform of Bridge-like lipid transfer protein family member 3B OS=Bos taurus OX=9913 GN=BLTP3B PE=4 SV=1 CANONICAL=F1N099-1" }, "locus": { "chromosome": "5", "start_pos": 64165062, "end_pos": 64075274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088208.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088208.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086314.1" } ] } }, { "isoform_ac": "F1N099-1", "url": "https://www.uniprot.org/uniprotkb/F1N099/entry", "sequence": { "sequence": "MAGLIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRNPNGPSPIATASGQSEYGFAEKVVEGITVSVNSIVIRIGAKAFNASFELSQLRIYSVNANWEHGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMFAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAPEPTQSSAVAPSTQHAKTPQTSNAPDLSDAIVKLFSDFDVKETSHHLVVSHLDLHICDDIHAKEKESNRRITGGAMQLSFTQLTIDYYPYHKAGDSCNHWMYFSDATKTKNGWANELLHEFECNVEMLKQAVKDHNVGSPPKSPTHASPQHTQTEKDSALKGASKKPSALSQQSKVKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMISCNKKSLYLPQEMSAVYIEFTEYYYPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFVLDLKQSLNQFMAVYKLNDNSKSDEHVDIRVDGLMLKVPYKQVAVRIKPFLQKKSYQHCNFQDLRWFVIPSEMKSECHQDQPRAISIQSSEMIATNTRHCPNCRHSDLEALFQDFKDCDFFSKTYTSFPKSGDNFNLLHPIFQRHAHEQDTKLHEVYKGNVTPKLNKHTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPINFVDSFPLSIWICQPKRYAVSQKSLQTCNQISLNTSQSESSDLTGRWKRKKLLKEYYSTECDPLTSGGQKPSSDTFLRFSSPSSDADIHVLVHVRKHVSMQINHYQYLLLLFLHESLILLSENLRKDVEAVTGSPASQTSVCIGILLKSAEVALLLHPVDQANTLKSPVSESVSPMVPDYLPAENGEFLPSKRKHVSSGINQIRSVTLNHMSDNRSMSVDLSHVPVKDSLLFKSASDTNLQKDISSLNYLSDKNLGKISEVESSGLVSQSGSGEIGSETSGKKVSSYTDSNSVLNYREDSSILSFDDGGNQNILSNSLTSKRSETIESIFKAEDLLPETASLSENVEISKEEAPTIRTLKSQSSLSGKPKERCLPTLAPVSTYKNMRRSPSQTSLDTISLDSMILEEQLLESDGSDSHIFLEKGIKKNSTTNYQSPADQTNASANLQNYGETSPDAISTNSEGAQESHDDLMSIVVFKITGVNGEIDIRGEDTEICLQVDQVIPDQLGNISLRHYLSHRPVGSDHKAVIHSKSSPEITLRFESGPGAVIHSLLAEKNGFLQCHIENFSTEFLVSSLMNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRSSTISLEPAPVTVHIDHLVVERNDDGSFHIRDSQILNTRNDLEENVKSDSVLHTSGTCDLKKKHSVTQATQTSPEVPWPLQSANFPECSFDFTREQLMEENESLKQELAKAKMALAEAHLEKDALLHQLNIRSGSQKLKL", "length": 1496, "header": "tr|F1N099-1|F1N099_BOVIN Isoform 1 of Bridge-like lipid transfer protein family member 3B OS=Bos taurus OX=9913 GN=BLTP3B PE=4 SV=4 CANONICAL=F1N099-1" }, "locus": { "chromosome": "5", "start_pos": 64165062, "end_pos": 64075274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007936.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007936.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007936.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007936.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 279, "start_aa": "Thr", "end_pos": 279, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr279", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "pmid": "" }, { "name": "lipid transfer activity", "id": "GO:0120013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120013", "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "pmid": "" }, { "name": "GARP complex binding", "id": "GO:0062069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062069", "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "early endosome to Golgi transport", "id": "GO:0034498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034498", "evidence": [ { "database": "UniProtKB", "id": "F1N099", "url": "https://www.uniprot.org/uniprotkb/F1N099" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1173, "end_pos": 1175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1186, "end_pos": 1188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1254, "end_pos": 1256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1311, "end_pos": 1313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1457, "end_pos": 1459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" }, { "start_pos": 779, "end_pos": 781, "annotation": "n_glycosylation_sequon" }, { "start_pos": 959, "end_pos": 961, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 279 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1173, "end_pos": 1175 }, { "start_pos": 1186, "end_pos": 1188 }, { "start_pos": 1254, "end_pos": 1256 }, { "start_pos": 1311, "end_pos": 1313 }, { "start_pos": 142, "end_pos": 144 }, { "start_pos": 1457, "end_pos": 1459 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 212, "end_pos": 214 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 704, "end_pos": 706 }, { "start_pos": 779, "end_pos": 781 }, { "start_pos": 959, "end_pos": 961 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0L3-1", "uniprot_ac": "F1N0L3", "uniprot_id": "F1N0L3_BOVIN", "mass": { "chemical_mass": 18000.0, "monoisotopic_mass": 18000.0 }, "refseq": { "ac": "NP_001185934", "name": "transcription factor HES-2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185934" }, "gene_names": [ { "name": "HES2", "type": "recommended", "evidence": [ { "id": "F1N0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ] }, { "name": "HES2", "type": "synonym", "evidence": [ { "id": "NP_001185934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185934" } ] } ], "protein_names": [ { "name": "Hes family bHLH transcription factor 2", "type": "synonym", "evidence": [ { "id": "F1N0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L3/entry#names_and_taxonomy" } ] }, { "name": "hairy and enhancer of split 2", "type": "synonym", "evidence": [ { "id": "NP_001185934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185934" } ] }, { "name": "transcription factor HES-2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001185934", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185934" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HES2", "url": "https://www.uniprot.org/uniprotkb/F1N0L3", "locus": { "chromosome": "16", "start_pos": 46952589, "end_pos": 46950102, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021210", "url": "https://www.ensembl.org/id/ENSBTAG00000021210" } ] } } ], "crossref": [ { "id": "F1N0L3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021210", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021210", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516433", "url": "https://www.ncbi.nlm.nih.gov/gene/516433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516433", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NSTGPMW", "url": "https://omabrowser.org/oma/group/NSTGPMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0L3", "url": "https://www.orthodb.org/?gene=F1N0L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001185934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185934", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SA56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPRRAGDPAELRKSLKPLLEKRRRARINESLSQLKGLILPLLGRESSRYSKLEKADILEMTVRFLQELPASSGPTAAPTPSDSYREGYRACLARLARVLPTCRVLEPAVSARLLEHLRRRAASATSDGGRSGDPCGPPAPSPPPAPSPSPPEPPRNSGLWRPW", "length": 165, "header": "tr|F1N0L3-1|F1N0L3_BOVIN Isoform 1 of Hes family bHLH transcription factor 2 OS=Bos taurus OX=9913 GN=HES2 PE=4 SV=2 CANONICAL=F1N0L3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA56/entry", "sequence": { "sequence": "MGLPRRAGDPAELRKSLKPLLEKRRRARINESLSQLKGLILPLLGREHPPTATARATEPAWRAWLACYPPAAFWSLR", "length": 77, "header": "tr|A0AAA9SA56-1|F1N0L3_BOVIN Computationally mapped isoform of Hes family bHLH transcription factor 2 OS=Bos taurus OX=9913 GN=HES2 PE=4 SV=1 CANONICAL=F1N0L3-1" }, "locus": { "chromosome": "16", "start_pos": 46950986, "end_pos": 46950217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109312.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109312.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082203.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082203.1" } ] } }, { "isoform_ac": "F1N0L3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L3/entry", "sequence": { "sequence": "MGLPRRAGDPAELRKSLKPLLEKRRRARINESLSQLKGLILPLLGRESSRYSKLEKADILEMTVRFLQELPASSGPTAAPTPSDSYREGYRACLARLARVLPTCRVLEPAVSARLLEHLRRRAASATSDGGRSGDPCGPPAPSPPPAPSPSPPEPPRNSGLWRPW", "length": 165, "header": "tr|F1N0L3-1|F1N0L3_BOVIN Isoform 1 of Hes family bHLH transcription factor 2 OS=Bos taurus OX=9913 GN=HES2 PE=4 SV=2 CANONICAL=F1N0L3-1" }, "locus": { "chromosome": "16", "start_pos": 46951150, "end_pos": 46950217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028261.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028261.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028261.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028261.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 77, "start_aa": "Thr", "end_pos": 77, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 81, "start_aa": "Thr", "end_pos": 81, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr81", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516433", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516433", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A5I8-1", "protein_name": "Hes family bHLH transcription factor 2", "gene_name": "HES2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLPRRAGDPAELRKNLKPLLEKRRRARINASLSQLKGLILPLLGRESSHYSKLEKADILEMTVRFLQELPASSCPTAAPTSSDSYREGYRACLARLARVLPACRVLEPALSARLLEHLRRRAACATPDSGRAGDPSGPPAPSPPPAPAPSPPVPPRGPSLWRPW", "length": 165 }, "evidence": [ { "id": "F1N0L3", "url": "https://omabrowser.org/oma/group/F1N0L3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O54792-1", "protein_name": "Transcription factor HES-2", "gene_name": "Hes2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLPRRVEDAAELRKNLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILEMTVRFLQEQPATLYSSAAPGPLNSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQRTVSDDSPSLTLPPAPAPAPSPPVPPPGSSGLWRPW", "length": 157 }, "evidence": [ { "id": "F1N0L3", "url": "https://omabrowser.org/oma/group/F1N0L3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P35429-1", "protein_name": "Transcription factor HES-2", "gene_name": "Hes2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLPRGVGDAAELRKSLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQPASVCSTEAPGSLDSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQRTVSGGPPSLTPASASAPAPSPPVPPPSSLGLWRPW", "length": 157 }, "evidence": [ { "id": "F1N0L3", "url": "https://omabrowser.org/oma/group/F1N0L3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q01069-1", "protein_name": "Enhancer of split mbeta protein", "gene_name": "E(spl)mbeta-HLH", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVLEMEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPMWRPW", "length": 195 }, "evidence": [ { "id": "F1N0L3", "url": "https://omabrowser.org/oma/group/F1N0L3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y543-1", "protein_name": "Transcription factor HES-2", "gene_name": "HES2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW", "length": 173 }, "evidence": [ { "id": "F1N0L3", "url": "https://omabrowser.org/oma/group/F1N0L3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N0L3", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0L3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 165, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0L3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0L3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 70, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L3" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 86, "end_pos": 119, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 77, 81 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0A3-1", "uniprot_ac": "F1N0A3", "uniprot_id": "F1N0A3_BOVIN", "mass": { "chemical_mass": 27717.0, "monoisotopic_mass": 27717.0 }, "refseq": { "ac": "NP_001192647", "name": "vacuolar protein sorting-associated protein 37D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192647" }, "gene_names": [ { "name": "VPS37D", "type": "recommended", "evidence": [ { "id": "F1N0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ] }, { "name": "VPS37D", "type": "synonym", "evidence": [ { "id": "NP_001192647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192647" } ] } ], "protein_names": [ { "name": "VPS37D subunit of ESCRT-I", "type": "synonym", "evidence": [ { "id": "F1N0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A3/entry#names_and_taxonomy" } ] }, { "name": "VPS37D, ESCRT-I subunit", "type": "synonym", "evidence": [ { "id": "NP_001192647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192647" } ] }, { "name": "vacuolar protein sorting-associated protein 37D", "type": "synonym", "evidence": [ { "id": "NP_001192647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192647" } ] } ], "function": [ { "annotation": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD3#function" }, { "database": "UniProtKB", "id": "ARBA00025010", "url": "https://www.uniprot.org/uniprotkb/ARBA00025010#function" }, { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS37D", "url": "https://www.uniprot.org/uniprotkb/F1N0A3", "locus": { "chromosome": "25", "start_pos": 33581325, "end_pos": 33585690, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008487", "url": "https://www.ensembl.org/id/ENSBTAG00000008487" } ] } } ], "crossref": [ { "id": "F1N0A3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0A3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008487", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008487", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539811", "url": "https://www.ncbi.nlm.nih.gov/gene/539811", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539811", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539811", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WQFQGLQ", "url": "https://omabrowser.org/oma/group/WQFQGLQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0A3", "url": "https://www.orthodb.org/?gene=F1N0A3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13678:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13678:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192647", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0A3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0A3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLEREACLASNYALAKENLALRPRLEMGRTALAIKYQELREVAESCADKLQRLEESMHRWSPHCALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSGQPAPTAAAEPPKSFPAAAVLPTGAARGPPAVPRSLPPLDSRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR", "length": 251, "header": "tr|F1N0A3-1|F1N0A3_BOVIN Isoform 1 of VPS37D subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37D PE=3 SV=3 CANONICAL=F1N0A3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD3/entry", "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSGQPAPTAAAEPPKSFPAAAVLPTGAARGPPAVPRSLPPLDSRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR", "length": 166, "header": "tr|A0AAA9SBD3-1|F1N0A3_BOVIN Computationally mapped isoform of VPS37D subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37D PE=3 SV=1 CANONICAL=F1N0A3-1" }, "locus": { "chromosome": "25", "start_pos": 33585455, "end_pos": 33582299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134226.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134226.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082698.1" } ] } }, { "isoform_ac": "F1N0A3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0A3/entry", "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLEREACLASNYALAKENLALRPRLEMGRTALAIKYQELREVAESCADKLQRLEESMHRWSPHCALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSGQPAPTAAAEPPKSFPAAAVLPTGAARGPPAVPRSLPPLDSRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR", "length": 251, "header": "tr|F1N0A3-1|F1N0A3_BOVIN Isoform 1 of VPS37D subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37D PE=3 SV=3 CANONICAL=F1N0A3-1" }, "locus": { "chromosome": "25", "start_pos": 33585455, "end_pos": 33582299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011185.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011185.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011185.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011185.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 184, "start_aa": "Thr", "end_pos": 184, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr184", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539811", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539811", "resource": "KEGG Pathway" }, { "id": "R-BTA-917729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AS36-1", "protein_name": "VPS37D subunit of ESCRT-I", "gene_name": "VPS37D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLEREACLASNYALAKENLALRPRLEMGRAALAIKYQELREVAESCADKLQRLEDSMHRWSPHFALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSGQPAPTAAADPPKSLPAAAVLPTGASRGPPAVPRSLPPLDSRPVPPLKSSPGCPLGPAPLLSPRPLQPEPPHR", "length": 251 }, "evidence": [ { "id": "F1N0A3", "url": "https://omabrowser.org/oma/group/F1N0A3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9PZ52-1", "protein_name": "Vacuolar protein sorting-associated protein 37D", "gene_name": "vps37d", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADKRSCLVRLTGTRMSQKSDANSYPDGYRVLNSCELRELLQDEDKMNQIVRLSEKFQELQMDRDTLLVTNRSLAEDSLTRRPHLQNGKLQLAAKYEELATLSTACREKQSRLEAFTEKHSPQTAHNLLQEEVTRAEEQSEELLERFMEGHVPLEEFLDCFQSHRKTYHIRRAQAEKLQELNRPGRKAKKQEEEQHKREDQLKESHSNGISGPPRVFQLRYGLTPAILLPLSSSSASILDSRSGQPQGSGPSAPHSCPGQPVGLRVIGQLPGWPVRPVRLQQLYRPSPHQPEPPCR", "length": 296 }, "evidence": [ { "id": "F1N0A3", "url": "https://omabrowser.org/oma/group/F1N0A3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V1AIQ2-1", "protein_name": "VPS37D subunit of ESCRT-I", "gene_name": "VPS37D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARPPAPPGAPRCFGALSTGQLRALLQDEPRLQRAVRLSKKFQALQREREERLAANSALARDNLALRPRLEDGKAALAIKYQELREVREACRAKLRRLEAYLEECGPQRALGRLRAALDASEAEAETQMQRFLAHEVPLDAFLESFCRSRARSHVSRTQLEKLQELLQRGRDPEGEPQGLNPASGRGAASPKAPQLRCGFVPAVLVPAAAVVPFAVPPKRRLPALGQPQPAPHAAPLSPRPFRRREPEPLQP", "length": 252 }, "evidence": [ { "id": "F1N0A3", "url": "https://omabrowser.org/oma/group/F1N0A3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2GV76-1", "protein_name": "VPS37D subunit of ESCRT-I", "gene_name": "Vps37d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLERDACLASNYALAKENLALRPRLEMGRTALAIKYQELREVAENCADKLQRLEKSMHRWSPQCALGWLQAELEEAEQEAEVQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQEVLRRRERSAQPAPTTAAAAAAAATAMDPPKPFPAAAVLPTGAARGPPPAVPRSLPPLDSRPVPPVKGSPGCPFGPAPLLSPRPSQPEPPHR", "length": 261 }, "evidence": [ { "id": "F1N0A3", "url": "https://omabrowser.org/oma/group/F1N0A3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q810I0-1", "protein_name": "Vacuolar protein sorting-associated protein 37D", "gene_name": "Vps37d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLERDACLASNYALAKENLALRPRLEMGRTALAIKYQELREVAENCADKLQRLEKSMHRWSPQCALGWLQAELEEAEQEAEVQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQEVLRRRERSAQPAPTTAAAAAAAATAMDPPKPFPAAAVLPTGAARGPPPAVPRSLPPLDSRPVPPVKGSPGCPFGPAPLLSPRPSQPEPPHR", "length": 261 }, "evidence": [ { "id": "F1N0A3", "url": "https://omabrowser.org/oma/group/F1N0A3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86XT2-1", "protein_name": "Vacuolar protein sorting-associated protein 37D", "gene_name": "VPS37D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLEREACLASNYALAKENLALRPRLEMGRAALAIKYQELREVAENCADKLQRLEESMHRWSPHCALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSAQPAPTSAADPPKSFPAAAVLPTGAARGPPAVPRSLPPLDSRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR", "length": 251 }, "evidence": [ { "id": "F1N0A3", "url": "https://omabrowser.org/oma/group/F1N0A3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "pmid": "" }, { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "pmid": "" }, { "name": "protein targeting to vacuole", "id": "GO:0006623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006623", "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "id": "GO:0043162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043162", "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "pmid": "" }, { "name": "ESCRT I complex", "id": "GO:0000813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000813", "evidence": [ { "database": "UniProtKB", "id": "F1N0A3", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0A3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 251, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0A3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0A3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0A3" }, { "id": "PS51314", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51314" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VPS37 C-terminal", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 182, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 184 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N191-1", "uniprot_ac": "F1N191", "uniprot_id": "F1N191_BOVIN", "mass": { "chemical_mass": 65759.0, "monoisotopic_mass": 65759.0 }, "refseq": {}, "gene_names": [ { "name": "IL4I1", "type": "recommended", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ] } ], "protein_names": [ { "name": "L-amino-acid oxidase", "type": "recommended", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191/entry#names_and_taxonomy" } ] }, { "name": "1.4.3.25", "type": "synonym", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191/entry#names_and_taxonomy" } ] }, { "name": "1.4.3.2", "type": "synonym", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191/entry#names_and_taxonomy" } ] }, { "name": "Interleukin-4-induced protein 1", "type": "synonym", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191/entry#names_and_taxonomy" } ] }, { "name": "Protein Fig-1", "type": "synonym", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL4I1", "url": "https://www.uniprot.org/uniprotkb/F1N191", "locus": { "chromosome": "18", "start_pos": 56233982, "end_pos": 56243450, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005766", "url": "https://www.ensembl.org/id/ENSBTAG00000005766" } ] } } ], "crossref": [ { "id": "F1N191", "url": "https://alphafold.ebi.ac.uk/entry/F1N191", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005766", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005766", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "104968452", "url": "https://www.ncbi.nlm.nih.gov/gene/104968452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968452", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968452", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N191", "url": "https://www.orthodb.org/?gene=F1N191", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01593", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8964208", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964208", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "13781", "url": "https://www.rhea-db.org/rhea/13781", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "51404", "url": "https://www.rhea-db.org/rhea/51404", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61240", "url": "https://www.rhea-db.org/rhea/61240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61244", "url": "https://www.rhea-db.org/rhea/61244", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61248", "url": "https://www.rhea-db.org/rhea/61248", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N191-1", "url": "https://www.uniprot.org/uniprotkb/F1N191-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQHISNPDTRVMDPLAWRLLALVPVFLSLAASLDWQTAHIYDPFEKCMHDPDYEQLLKVVTLGLNRTLNPRRVVVVGAGVAGLVAAKVLSDAGHKVTILEADSRIGGRILTYRDRKTGWIGELGAMRMPSSHRILHELCKSLGLNLTKFTQYDENTWTEVNEVKLRNYVVEKMPEKLGYKLSPKEKGRSPEEIYQMALNRAIKDLRTLGCKKAMMKFERHTLLEYLLGEGNLSQPAVRLLGDVMSKDGFFYLSFAEALRAHSCLSDRLRYSRIVGGWDLLPRALLSSLSGPVLLHAPVVAIKQGTHEVKVHIKPSRRTRNLKSMMADVVLLTVSGPALQRIAFTPPLTRRRQEAVRGLHYVPATKVFLSFRRPFWHDEHIEGGHSSTDRPSRVIFYPAPGDGALLLASYTWSDAAAPFAGRSLAESLRLALDDVAALHGPIAYRLWDGTGIIKRWAEDPHSQGGFVVQPPTLFQTDKDEGREFDWSVPYGRIYFAGEHTAYPHGWVETAVKSALRAAILINSRISGSGSSSSLKEPRIVNKVGHGHLTPSHHQHHHHHHRCPFESGQGTHSPASHAVTAAHSTLKKSQY", "length": 589, "header": "tr|F1N191-1|F1N191_BOVIN Isoform 1 of L-amino-acid oxidase OS=Bos taurus OX=9913 GN=IL4I1 PE=3 SV=4 CANONICAL=F1N191-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH0/entry", "sequence": { "sequence": "MGTERACQSQPCTWRLLALVPVFLSLAASLDWQTAHIYDPFEKCMHDPDYEQLLKVVTLGLNRTLNPRRVVVVGAGVAGLVAAKVLSDAGHKVTILEADSRIGGRILTYRDRKTGWIGELGAMRMPSSHRILHELCKSLGLNLTKFTQYDENTWTEVNEVKLRNYVVEKMPEKLGYKLSPKEKGRSPEEIYQMALNRAIKDLRTLGCKKAMMKFERHTLLEYLLGEGNLSQPAVRLLGDVMSKDGFFYLSFAEALRAHSCLSDRLRYSRIVGGWDLLPRALLSSLSGPVLLHAPVVAIKQGTHEVKVHIKPSRRTRNLKSMMADVVLLTVSGPALQRIAFTPPLTRRRQEAVRGLHYVPATKVFLSFRRPFWHDEHIEGGHSSTDRPSRVIFYPAPGDGALLLASYTWSDAAAPFAGRSLAESLRLALDDVAALHGPIAYRLWDGTGIIKRWAEDPHSQGGFVVQPPTLFQTDKDEGREFDWSVPYGRIYFAGEHTAYPHGWVETAVKSALRAAILINSRISGSGSSSSLKEPRIVNKVGHGHLTPSHHQHHHHHHRCPFESGQGTHSPASHAVTAAHSTLKKSQY", "length": 586, "header": "tr|A0AAA9SBH0-1|F1N191_BOVIN Computationally mapped isoform of L-amino-acid oxidase OS=Bos taurus OX=9913 GN=IL4I1 PE=3 SV=1 CANONICAL=F1N191-1" }, "locus": { "chromosome": "18", "start_pos": 56243281, "end_pos": 56235070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121523.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121523.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079551.1" } ] } }, { "isoform_ac": "A0AAA9T5X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5X5/entry", "sequence": { "sequence": "MDPLAWRLLALVPVFLSLAASLDWQTAHIYDPFEKCMHDPDYEQLLKVVTLGLNRTLNPRRVVVVGAGVAGLVAAKVLSDAGHKVTILEADSRIGGRILTYRDRKTGWIGELGAMRMPSSHRILHELCKSLGLNLTKFTQYDENTWTEVNEVKLRNYVVEKMPEKLGYKLSPKEKGRSPEEIYQMALNRAIKDLRTLGCKKAMMKFERHTLLEYLLGEGNLSQPAVRLLGDVMSKDGFFYLSFAEALRAHSCLSDRLRYSRIVGGWDLLPRALLSSLSGPVLLHAPVVAIKQGTHEVKVHIKPSRRTRNLKSMMADVVLLTVSGPALQRIAFTPPLTRRRQEAVRGLHYVPATKVFLSFRRPFWHDEHIEGGHSSTDRPSRVIFYPAPGDGALLLASYTWSDAAAPFAGRSLAESLRLALDDVAALHGPIAYRLWDGTGIIKRWAEDPHSQGGFVVQPPTLFQTDKDEGREFDWSVPYGRIYFAGEHTAYPHGWVETAVKSALRAAILINSRISGSGSSSSLKEPRIVNKFAGRRT", "length": 536, "header": "tr|A0AAA9T5X5-1|F1N191_BOVIN Computationally mapped isoform of L-amino-acid oxidase OS=Bos taurus OX=9913 GN=IL4I1 PE=3 SV=1 CANONICAL=F1N191-1" }, "locus": { "chromosome": "18", "start_pos": 56239827, "end_pos": 56234986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128326.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128326.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091965.1" } ] } }, { "isoform_ac": "F1N191-1", "url": "https://www.uniprot.org/uniprotkb/F1N191/entry", "sequence": { "sequence": "MQHISNPDTRVMDPLAWRLLALVPVFLSLAASLDWQTAHIYDPFEKCMHDPDYEQLLKVVTLGLNRTLNPRRVVVVGAGVAGLVAAKVLSDAGHKVTILEADSRIGGRILTYRDRKTGWIGELGAMRMPSSHRILHELCKSLGLNLTKFTQYDENTWTEVNEVKLRNYVVEKMPEKLGYKLSPKEKGRSPEEIYQMALNRAIKDLRTLGCKKAMMKFERHTLLEYLLGEGNLSQPAVRLLGDVMSKDGFFYLSFAEALRAHSCLSDRLRYSRIVGGWDLLPRALLSSLSGPVLLHAPVVAIKQGTHEVKVHIKPSRRTRNLKSMMADVVLLTVSGPALQRIAFTPPLTRRRQEAVRGLHYVPATKVFLSFRRPFWHDEHIEGGHSSTDRPSRVIFYPAPGDGALLLASYTWSDAAAPFAGRSLAESLRLALDDVAALHGPIAYRLWDGTGIIKRWAEDPHSQGGFVVQPPTLFQTDKDEGREFDWSVPYGRIYFAGEHTAYPHGWVETAVKSALRAAILINSRISGSGSSSSLKEPRIVNKVGHGHLTPSHHQHHHHHHRCPFESGQGTHSPASHAVTAAHSTLKKSQY", "length": 589, "header": "tr|F1N191-1|F1N191_BOVIN Isoform 1 of L-amino-acid oxidase OS=Bos taurus OX=9913 GN=IL4I1 PE=3 SV=4 CANONICAL=F1N191-1" }, "locus": { "chromosome": "18", "start_pos": 56243249, "end_pos": 56235070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007580.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007580.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007580.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007580.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:104968452", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968452", "resource": "KEGG Pathway" }, { "id": "R-BTA-8964208", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964208", "resource": "Reactome", "description": "Phenylalanine metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "immunological synapse", "id": "GO:0001772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "positive regulation of regulatory T cell differentiation", "id": "GO:0045591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045591", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "aromatic amino acid metabolic process", "id": "GO:0009072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009072", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "negative regulation of T cell mediated immune response to tumor cell", "id": "GO:0002841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002841", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "negative regulation of T cell proliferation", "id": "GO:0042130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042130", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "L-phenylalanine catabolic process", "id": "GO:0006559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006559", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "L-tyrosine catabolic process", "id": "GO:0006572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006572", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "amino acid catabolic process", "id": "GO:0009063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009063", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" }, { "name": "L-tryptophan catabolic process to indole-3-acetate", "id": "GO:0019440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019440", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-amino-acid oxidase activity", "id": "GO:0001716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001716", "evidence": [ { "database": "UniProtKB", "id": "F1N191", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13781", "name": "", "equation": "an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MZA0-1", "F1N191-1" ], "evidence": [ { "id": "13781", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13781" } ] }, { "id": "51404", "name": "", "equation": "L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N191-1" ], "evidence": [ { "id": "51404", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51404" } ] }, { "id": "61240", "name": "", "equation": "L-phenylalanine + O2 + H2O = 3-phenylpyruvate + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N191-1" ], "evidence": [ { "id": "61240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61240" } ] }, { "id": "61244", "name": "", "equation": "L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N191-1" ], "evidence": [ { "id": "61244", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61244" } ] }, { "id": "61248", "name": "", "equation": "L-tyrosine + O2 + H2O = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N191-1" ], "evidence": [ { "id": "61248", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61248" } ] }, { "id": "R-BTA-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [ "R-ALL-352327", "R-ALL-351993" ], "output_participant_list": [ "R-ALL-2160466" ], "enzyme_list": [ "F1N191-1" ], "evidence": [ { "id": "R-BTA-2160492", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160492" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2160466", "participant_name": "kPPV [extracellular region]", "crossref": [ { "id": "PHENYL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "C00166", "database": "COMPOUND", "url": "" }, { "id": "156-06-9", "database": "CAS", "url": "" }, { "id": "ZINC000000901485", "database": "ZINC", "url": "" }, { "id": "C00000751", "database": "KNApSAcK", "url": "" }, { "id": "18005", "database": "ChEBI", "url": "" }, { "id": "4592697", "database": "PubChem Compound", "url": "" } ] }, { "participant_id": "R-ALL-351993", "participant_name": "L-Phe [extracellular region]", "crossref": [ { "id": "58095", "database": "ChEBI", "url": "" }, { "id": "ZINC000000105196", "database": "ZINC", "url": "" }, { "id": "C00079", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-352327", "participant_name": "O2 [extracellular region]", "crossref": [ { "id": "15379", "database": "ChEBI", "url": "" }, { "id": "8145133", "database": "PubChem Substance", "url": "" }, { "id": "C00007", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001377", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MZA0", "gene_name": "", "activity": [ { "ec_number": "1.4.3.-", "activity": "", "evidence": [ { "id": "F1MZA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZA0" } ] } ] }, { "uniprot_ac": "F1N191", "gene_name": "IL4I1", "activity": [ { "ec_number": "1.4.3.2", "activity": "an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+).", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ] }, { "ec_number": "1.4.3.25", "activity": "L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+).", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ] }, { "ec_number": "1.4.3.2", "activity": "", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ] }, { "ec_number": "1.4.3.25", "activity": "", "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N191-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 589, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N191-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N191" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N191" }, { "id": "PF01593", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amine oxidase", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 517, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.4.3.2", "ec_name": "an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+).", "evidence": [ { "id": "1.4.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.2" }, { "id": "1.4.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.4.3.2" } ] }, { "ec_number": "1.4.3.25", "ec_name": "L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+).", "evidence": [ { "id": "1.4.3.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MZV7-1", "uniprot_ac": "F1MZV7", "uniprot_id": "F1MZV7_BOVIN", "mass": { "chemical_mass": 17692.0, "monoisotopic_mass": 17692.0 }, "refseq": {}, "gene_names": [ { "name": "IL21", "type": "recommended", "evidence": [ { "id": "F1MZV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ] } ], "protein_names": [ { "name": "Interleukin", "type": "recommended", "evidence": [ { "id": "F1MZV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZV7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM7#function" }, { "database": "UniProtKB", "id": "ARBA00045924", "url": "https://www.uniprot.org/uniprotkb/ARBA00045924#function" }, { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL21", "url": "https://www.uniprot.org/uniprotkb/F1MZV7", "locus": { "chromosome": "17", "start_pos": 35071245, "end_pos": 35062902, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012368", "url": "https://www.ensembl.org/id/ENSBTAG00000012368" } ] } } ], "crossref": [ { "id": "F1MZV7", "url": "https://alphafold.ebi.ac.uk/entry/F1MZV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012368", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MIHQHLR", "url": "https://omabrowser.org/oma/group/MIHQHLR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MZV7", "url": "https://www.orthodb.org/?gene=F1MZV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14356:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14356:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9020958", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020958", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZV7-1", "url": "https://www.uniprot.org/uniprotkb/F1MZV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSTPGNMERIVICLMVIFSGTVAHKSSSQGQDRLFIRLRQLIDIVDQLKNYVNDLDPEFLPAPEDVKRHCERSAFSCFQKVQLKSANNGDNEKIINILTKQLKRKLPATNTGRRQKHEVTCPSCDSYEKKPPKEYLERLKSLIQKMIHQHLS", "length": 153, "header": "tr|F1MZV7-1|F1MZV7_BOVIN Isoform 1 of Interleukin OS=Bos taurus OX=9913 GN=IL21 PE=3 SV=2 CANONICAL=F1MZV7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM7/entry", "sequence": { "sequence": "ILKAVSRAASLLLFLFEAAFGVHLKPNPAAVCPGPQIARDSCAACRKHKAKFHCVLTQRHCERSAFSCFQKVQLKSANNGDNEKIINILTKQLKRKLPATNTGRRQKHEVTCPSCDSYEKKPPKEYLERLKSLIQKMIHQHLS", "length": 143, "header": "tr|A0AAA9SBM7-1|F1MZV7_BOVIN Computationally mapped isoform of Interleukin OS=Bos taurus OX=9913 GN=IL21 PE=3 SV=1 CANONICAL=F1MZV7-1" }, "locus": { "chromosome": "17", "start_pos": 35070241, "end_pos": 35065773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113279.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113279.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079626.1" } ] } }, { "isoform_ac": "F1MZV7-1", "url": "https://www.uniprot.org/uniprotkb/F1MZV7/entry", "sequence": { "sequence": "MRSTPGNMERIVICLMVIFSGTVAHKSSSQGQDRLFIRLRQLIDIVDQLKNYVNDLDPEFLPAPEDVKRHCERSAFSCFQKVQLKSANNGDNEKIINILTKQLKRKLPATNTGRRQKHEVTCPSCDSYEKKPPKEYLERLKSLIQKMIHQHLS", "length": 153, "header": "tr|F1MZV7-1|F1MZV7_BOVIN Isoform 1 of Interleukin OS=Bos taurus OX=9913 GN=IL21 PE=3 SV=2 CANONICAL=F1MZV7-1" }, "locus": { "chromosome": "17", "start_pos": 35070241, "end_pos": 35063101, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016413.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016413.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016413.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016413.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9020958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020958", "resource": "Reactome", "description": "Interleukin-21 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A3QPB9-1", "protein_name": "Interleukin-21", "gene_name": "Il21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS", "length": 146 }, "evidence": [ { "id": "F1MZV7", "url": "https://omabrowser.org/oma/group/F1MZV7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ES17-1", "protein_name": "Interleukin-21", "gene_name": "Il21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS", "length": 146 }, "evidence": [ { "id": "F1MZV7", "url": "https://omabrowser.org/oma/group/F1MZV7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HBE4-1", "protein_name": "Interleukin-21", "gene_name": "IL21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS", "length": 162 }, "evidence": [ { "id": "F1MZV7", "url": "https://omabrowser.org/oma/group/F1MZV7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "positive regulation of biosynthetic process", "id": "GO:0009891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009891", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "positive regulation of interleukin-17 production", "id": "GO:0032740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032740", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "germinal center B cell differentiation", "id": "GO:0002314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002314", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "positive regulation of T cell proliferation", "id": "GO:0042102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042102", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "cell maturation", "id": "GO:0048469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048469", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "positive regulation of immunoglobulin production", "id": "GO:0002639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002639", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "T follicular helper cell differentiation", "id": "GO:0061470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061470", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "cytokine receptor binding", "id": "GO:0005126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005126", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" }, { "name": "interleukin-2 receptor binding", "id": "GO:0005134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005134", "evidence": [ { "database": "UniProtKB", "id": "F1MZV7", "url": "https://www.uniprot.org/uniprotkb/F1MZV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MZV7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MZV7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MZV7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N109-1", "uniprot_ac": "F1N109", "uniprot_id": "F1N109_BOVIN", "mass": { "chemical_mass": 36502.0, "monoisotopic_mass": 36502.0 }, "refseq": { "ac": "XP_024854585", "name": "glycosyltransferase 6 domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854585" }, "gene_names": [ { "name": "GLT6D1", "type": "recommended", "evidence": [ { "id": "F1N109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ] }, { "name": "GLT6D1", "type": "synonym", "evidence": [ { "id": "XP_024854585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854585" } ] } ], "protein_names": [ { "name": "Glycosyltransferase 6 domain containing 1", "type": "synonym", "evidence": [ { "id": "F1N109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N109/entry#names_and_taxonomy" } ] }, { "name": "glycosyltransferase 6 domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024854585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854585" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLT6D1", "url": "https://www.uniprot.org/uniprotkb/F1N109", "locus": { "chromosome": "11", "start_pos": 103271493, "end_pos": 103279630, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020249", "url": "https://www.ensembl.org/id/ENSBTAG00000020249" } ] } } ], "crossref": [ { "id": "F1N109", "url": "https://alphafold.ebi.ac.uk/entry/F1N109", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020249", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020249", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529958", "url": "https://www.ncbi.nlm.nih.gov/gene/529958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WLAPILW", "url": "https://omabrowser.org/oma/group/WLAPILW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N109", "url": "https://www.orthodb.org/?gene=F1N109", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10462:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10462:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024854585", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854585", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N109-1", "url": "https://www.uniprot.org/uniprotkb/F1N109-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNCKRKMLLLILGLSLLLLFDHYSRKNQEEELELSDWFKPRGRPDVITTTSWLAPVVWEGTFSRKMLEKHYRRQNFTTGLAVFATGRLADPYLELFLNSANKYFLTGYRVIFYIMMDTFIKLPQIKWEPLRQFKVFIVTESRWWDNDVVRMKSLAKHIIWDIQGEVDFLFSMTVTQIFQNNVGVEVLGELVAQLHGWWYFKDRASFPYERRPKSAAYIPFGQGDFYYDGAFVGGTPQEVLNLAEEYLNGVIHDLGLRLNSSYEKHLNKYFFLRKPTKLLSPEYNWDADFYPPPQVQYVKVAQQSKRRH", "length": 308, "header": "tr|F1N109-1|F1N109_BOVIN Isoform 1 of Glycosyltransferase 6 domain containing 1 OS=Bos taurus OX=9913 GN=GLT6D1 PE=3 SV=1 CANONICAL=F1N109-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY3/entry", "sequence": { "sequence": "MNLSKLRVLVMDRGACLKNQEEELELSDWFKPRGRPDVITTTSWLAPVVWEGTFSRKMLEKHYRRQNFTTGLAVFATGRLADPYLELFLNSANKYFLTGYRVIFYIMMDTFIKLPQIKWEPLRQFKVFIVTESRWWDNDVVRMKSLAKHIIWDIQGEVDFLFSMTVTQIFQNNVGVEVLGELVAQLHGWWYFKDRASFPYERRPKSAAYIPFGQGDFYYDGAFVGGTPQEVLNLAEEYLNGVIHDLGLRLNSSYEKHLNKYFFLRKPTKLLSPEYNWDADFYPPPQVQYVKVAQQSKRRH", "length": 300, "header": "tr|A0AAA9SGY3-1|F1N109_BOVIN Computationally mapped isoform of Glycosyltransferase 6 domain containing 1 OS=Bos taurus OX=9913 GN=GLT6D1 PE=3 SV=1 CANONICAL=F1N109-1" }, "locus": { "chromosome": "11", "start_pos": 103274588, "end_pos": 103271681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094345.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094345.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085460.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085460.1" } ] } }, { "isoform_ac": "F1N109-1", "url": "https://www.uniprot.org/uniprotkb/F1N109/entry", "sequence": { "sequence": "MNCKRKMLLLILGLSLLLLFDHYSRKNQEEELELSDWFKPRGRPDVITTTSWLAPVVWEGTFSRKMLEKHYRRQNFTTGLAVFATGRLADPYLELFLNSANKYFLTGYRVIFYIMMDTFIKLPQIKWEPLRQFKVFIVTESRWWDNDVVRMKSLAKHIIWDIQGEVDFLFSMTVTQIFQNNVGVEVLGELVAQLHGWWYFKDRASFPYERRPKSAAYIPFGQGDFYYDGAFVGGTPQEVLNLAEEYLNGVIHDLGLRLNSSYEKHLNKYFFLRKPTKLLSPEYNWDADFYPPPQVQYVKVAQQSKRRH", "length": 308, "header": "tr|F1N109-1|F1N109_BOVIN Isoform 1 of Glycosyltransferase 6 domain containing 1 OS=Bos taurus OX=9913 GN=GLT6D1 PE=3 SV=1 CANONICAL=F1N109-1" }, "locus": { "chromosome": "11", "start_pos": 103278466, "end_pos": 103271681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026972.4", "url": "https://www.ensembl.org/id/ENSBTAT00000026972.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026972.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026972.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BK41-1", "protein_name": "Glycosyltransferase 6 domain containing 1", "gene_name": "GLT6D1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHLKRKVLLLVPWLSALLLLKRYFRNDRAEELPLSEWFDPRKRPDVVTTTSWHAPVIWEGTFRRQVLQRHYRKRNLTLGLAVFATGRLADEYLEPFLLSANEYFMRGHRVVFYVLVDTLDRLPELEWGPLRRLKVFIVSEDGWPSDFHLRRMSSLGRHIVEGIQGEVDFLFGMTVTQIFQNHVGVEALGTRVAQLHGWWYFQNTRSFPYERRPTSAACIPFGQGDFYYDGAFMGGTPLEVLDLIDEYLKGVIHDLNTGLNSTYEKHLNKYFFLRKPTKLLSPEYNWDAEFYPPPQVQYVKVAQRSKRRF", "length": 309 }, "evidence": [ { "id": "F1N109", "url": "https://omabrowser.org/oma/group/F1N109/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZNQ3-1", "protein_name": "Glycosyltransferase 6 domain-containing protein 1", "gene_name": "Glt6d1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKAKGRILLLTSCLFLLLLLLAKIHLRNHQEEELPLSDWFDPRRRLDVITTTDWLAPVIWEGTFDRKVLEKYYHKQNITMGLTVFAVSSFNGQYLDPFLQSASKFFMPGYRVIFYIMVDKSLKLPEMGHNPLQSFQVLVVSQERQWSDFDLMRMTVLSKHIREHIRFEVDFLFVMSVNMVFQNVFGVETLSTSVAQLHAWWYFRKTTHLPYERRPTSAAYIPFGLGDFYYAGAIIGGVPFQVLDFTHQYLKSVILDIENGVNSTYEKYLNKYFFLNKPTKLLSPEYSWDQTFNIPQQVHYVKVAHYPTDDL", "length": 311 }, "evidence": [ { "id": "F1N109", "url": "https://omabrowser.org/oma/group/F1N109/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2NKH9-1", "protein_name": "Glycosyltransferase 6 domain-containing protein 1", "gene_name": "Glt6d1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKAKRRILLQLLTFCLFLLLLAKIHFRNHQEEELLLSDWFNPRRRLDVITTTDWLAPIIWEGTFDRKVLETYFRKQNITVGLAVFAVGSLTDKYLDPFLQSASKFFMPGYRVIFYIMVDKYLQLQEMEHNPLQSFQVLKIGKERWWSNFDLMRMKILSEHIRDHIRYEVDFLFSMNINMVFQSEFGVETLSTSVAQLHPWWYFRKRTNLPYERKPTSVAHIPFGLGDFYYAGAIIGGVPFQVLDFAQQYLKGVFLDTENGVNSTYEKYLNKYFFLNKPTKLLSPEYSWDPTFNLPRHVWFVKIAHHPIDTL", "length": 311 }, "evidence": [ { "id": "F1N109", "url": "https://omabrowser.org/oma/group/F1N109/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z4J2-1", "protein_name": "Putative glycosyltransferase 6 domain-containing protein 1", "gene_name": "GLT6D1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSKRMLLLVLFAFSLMLVERYFRNHQVEELRLSDWFHPRKRPDVITKTDWLAPVLWEGTFDRRVLEKHYRRRNITVGLAVFATGRFAEEYLRPFLHSANKHFMTGYRVIFYIMVDAFFKLPDIEPSPLRTFKAFKVGTERWWLDGPLVHVKSLGEHIASHIQDEVDFLFSMAANQVFQNEFGVETLGPLVAQLHAWWYFRNTKNFPYERRPTSAACIPFGQGDFYYGNLMVGGTPHNILDFIKEYLNGVIHDIKNGLNSTYEKHLNKYFYLNKPT", "length": 276 }, "evidence": [ { "id": "F1N109", "url": "https://omabrowser.org/oma/group/F1N109/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hexosyltransferase activity", "id": "GO:0016758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016758", "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "pmid": "" }, { "name": "glycosyltransferase activity", "id": "GO:0016757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "evidence": [ { "database": "UniProtKB", "id": "F1N109", "url": "https://www.uniprot.org/uniprotkb/F1N109" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N109-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N109-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N109" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N005-1", "uniprot_ac": "F1N005", "uniprot_id": "F1N005_BOVIN", "mass": { "chemical_mass": 94358.0, "monoisotopic_mass": 94358.0 }, "refseq": { "ac": "XP_005225545", "name": "exocyst complex component 6 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225545" }, "gene_names": [ { "name": "EXOC6", "type": "recommended", "evidence": [ { "id": "F1N005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ] }, { "name": "EXOC6", "type": "synonym", "evidence": [ { "id": "XP_005225545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225545" } ] } ], "protein_names": [ { "name": "Exocyst complex component", "type": "recommended", "evidence": [ { "id": "F1N005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N005/entry#names_and_taxonomy" } ] }, { "name": "exocyst complex component 6 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005225545", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225545" } ] } ], "function": [ { "annotation": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI95#function" }, { "database": "UniProtKB", "id": "PIRNR025007", "url": "https://www.uniprot.org/uniprotkb/PIRNR025007#function" }, { "database": "UniProtKB", "id": "A0AAA9TCS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS6#function" }, { "database": "UniProtKB", "id": "A0AAA9TNM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM3#function" }, { "database": "UniProtKB", "id": "A0AAA9TRG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRG6#function" }, { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005#function" }, { "database": "UniProtKB", "id": "A0A3Q1M4P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXOC6", "url": "https://www.uniprot.org/uniprotkb/F1N005", "locus": { "chromosome": "26", "start_pos": 14401744, "end_pos": 14081701, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021116", "url": "https://www.ensembl.org/id/ENSBTAG00000021116" } ] } } ], "crossref": [ { "id": "F1N005", "url": "https://alphafold.ebi.ac.uk/entry/F1N005", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021116", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021116", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507518", "url": "https://www.ncbi.nlm.nih.gov/gene/507518", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4P7", "url": "https://www.orthodb.org/?gene=A0A3Q1M4P7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N005", "url": "https://www.orthodb.org/?gene=F1N005", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12702", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12702", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12702:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12702:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-264876", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264876", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225545", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225545", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4P7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N005-1", "url": "https://www.uniprot.org/uniprotkb/F1N005-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEIGEGPGTVPEHERILQEIQSTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEVLTVQDLVDFSPVYQCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLIVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPTNSSDHAAMSGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHT", "length": 813, "header": "tr|F1N005-1|F1N005_BOVIN Isoform 1 of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=2 CANONICAL=F1N005-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4P7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P7/entry", "sequence": { "sequence": "MAEIGEGPGTVPEHERILQEIQSTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEVLTVQDLVDFSPVYQCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHT", "length": 779, "header": "tr|A0A3Q1M4P7-1|A0A3Q1M4P7_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=2 CANONICAL=F1N005-1" }, "locus": { "chromosome": "26", "start_pos": 14400607, "end_pos": 14225106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084958.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084958.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063237.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063237.2" } ] } }, { "isoform_ac": "A0AAA9SI95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI95/entry", "sequence": { "sequence": "MAEIGEGPGTVPEHERILQEIQSTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEVLTVQDLVDFSPVYQCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLIVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQIIFSYKSSQNIE", "length": 734, "header": "tr|A0AAA9SI95-1|F1N005_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=1 CANONICAL=F1N005-1" }, "locus": { "chromosome": "26", "start_pos": 14367163, "end_pos": 14225106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125126.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125126.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083467.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083467.1" } ] } }, { "isoform_ac": "A0AAA9TCS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS6/entry", "sequence": { "sequence": "MMSAAGKSGAMLEEDPDQTYENVLAEIQSFELPIEATLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLIVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHT", "length": 785, "header": "tr|A0AAA9TCS6-1|F1N005_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=1 CANONICAL=F1N005-1" }, "locus": { "chromosome": "26", "start_pos": 14400607, "end_pos": 14211725, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089206.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089206.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096468.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096468.1" } ] } }, { "isoform_ac": "A0AAA9TNM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNM3/entry", "sequence": { "sequence": "MAEIGEGPGTVPEHERILQEIQSTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEGDEETFENYYRKQRKKQARLVLQPQSNMGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHT", "length": 700, "header": "tr|A0AAA9TNM3-1|F1N005_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=1 CANONICAL=F1N005-1" }, "locus": { "chromosome": "26", "start_pos": 14400607, "end_pos": 14225106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130828.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130828.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099962.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099962.1" } ] } }, { "isoform_ac": "A0AAA9TRG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRG6/entry", "sequence": { "sequence": "MLEEDPDQTYENVLAEIQSFELPIEATLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEVLTVQDLVDFSPVYQCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLIVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHT", "length": 798, "header": "tr|A0AAA9TRG6-1|F1N005_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=1 CANONICAL=F1N005-1" }, "locus": { "chromosome": "26", "start_pos": 14400607, "end_pos": 14211755, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101187.1" } ] } }, { "isoform_ac": "F1N005-1", "url": "https://www.uniprot.org/uniprotkb/F1N005/entry", "sequence": { "sequence": "MAEIGEGPGTVPEHERILQEIQSTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRTDAEKLKVQVTDTNRRFQDAGKEVIVQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSTKRYYSALKTMEQLENVYFPRVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQQQKIFTVTLQKQNNVKFGKTMYINDRIPEERNEIVLKHAFEEEDENEEEVLTVQDLVDFSPVYQCLHIYSVLGDEETFENYYRKQRKKQARLVLQPQSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLIVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPIVSEEEYRAIISKFPFQDPDLEKQPFPKKLPMSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIKKPHIGLTELVQIIINTTHLEQACKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFLRSIFQVFTHLPTNSSDHAAMSGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGMSQHT", "length": 813, "header": "tr|F1N005-1|F1N005_BOVIN Isoform 1 of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6 PE=3 SV=2 CANONICAL=F1N005-1" }, "locus": { "chromosome": "26", "start_pos": 14400607, "end_pos": 14225106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028134.8", "url": "https://www.ensembl.org/id/ENSBTAT00000028134.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028134.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028134.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-264876", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264876", "resource": "Reactome", "description": "Insulin processing" }, { "id": "R-BTA-5620916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620916", "resource": "Reactome", "description": "VxPx cargo-targeting to cilium" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "pmid": "" }, { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "pmid": "" }, { "name": "vesicle tethering involved in exocytosis", "id": "GO:0090522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090522", "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "F1N005", "url": "https://www.uniprot.org/uniprotkb/F1N005" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 652, "end_pos": 654, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N005-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 813, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N005-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N005" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N005" }, { "id": "PF20651", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20651" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Exocyst complex component EXOC6/Sec15 N-terminal", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 219, "start_aa": "Lys", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N005" }, { "id": "PF04091", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04091" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Exocyst complex subunit EXOC6/Sec15 C-terminal", "eco_id": "ECO_0000259", "start_pos": 412, "end_pos": 770, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 552, "end_pos": 554 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 652, "end_pos": 654 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N063-1", "uniprot_ac": "F1N063", "uniprot_id": "F1N063_BOVIN", "mass": { "chemical_mass": 42893.0, "monoisotopic_mass": 42893.0 }, "refseq": { "ac": "XP_024856682", "name": "calcium/calmodulin-dependent protein kinase type 1D isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856682" }, "gene_names": [ { "name": "CAMK1D", "type": "recommended", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "name": "CAMK1D", "type": "synonym", "evidence": [ { "id": "XP_024856682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856682" } ] } ], "protein_names": [ { "name": "calcium/calmodulin-dependent protein kinase", "type": "recommended", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.17", "type": "synonym", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063/entry#names_and_taxonomy" } ] }, { "name": "calcium/calmodulin-dependent protein kinase type 1D isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856682" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAMK1D", "url": "https://www.uniprot.org/uniprotkb/F1N063", "locus": { "chromosome": "13", "start_pos": 11672964, "end_pos": 12062796, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008650", "url": "https://www.ensembl.org/id/ENSBTAG00000008650" } ] } } ], "crossref": [ { "id": "F1N063", "url": "https://alphafold.ebi.ac.uk/entry/F1N063", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008650", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008650", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14083", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14083", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14168", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14168", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526873", "url": "https://www.ncbi.nlm.nih.gov/gene/526873", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526873", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526873", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RPKVQPC", "url": "https://omabrowser.org/oma/group/RPKVQPC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N063", "url": "https://www.orthodb.org/?gene=F1N063", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24347", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24347", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SK86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N063-1", "url": "https://www.uniprot.org/uniprotkb/F1N063-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLTSSTLCSFVSSASGVSGVGADRRPRPTTVTTVHSGSK", "length": 385, "header": "tr|F1N063-1|F1N063_BOVIN Isoform 1 of calcium/calmodulin-dependent protein kinase OS=Bos taurus OX=9913 GN=CAMK1D PE=3 SV=2 CANONICAL=F1N063-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK86/entry", "sequence": { "sequence": "MATEQRAEPGLSRLPASDSGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLTSSTLCSFVSSASGVSGVGADRRPRPTTVTTVHSGSK", "length": 373, "header": "tr|A0AAA9SK86-1|F1N063_BOVIN Computationally mapped isoform of calcium/calmodulin-dependent protein kinase OS=Bos taurus OX=9913 GN=CAMK1D PE=3 SV=1 CANONICAL=F1N063-1" }, "locus": { "chromosome": "13", "start_pos": 11942326, "end_pos": 11673968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096260.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096260.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086721.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086721.1" } ] } }, { "isoform_ac": "F1N063-1", "url": "https://www.uniprot.org/uniprotkb/F1N063/entry", "sequence": { "sequence": "MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLTSSTLCSFVSSASGVSGVGADRRPRPTTVTTVHSGSK", "length": 385, "header": "tr|F1N063-1|F1N063_BOVIN Isoform 1 of calcium/calmodulin-dependent protein kinase OS=Bos taurus OX=9913 GN=CAMK1D PE=3 SV=2 CANONICAL=F1N063-1" }, "locus": { "chromosome": "13", "start_pos": 12062597, "end_pos": 11673968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011406.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011406.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011406.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011406.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:526873", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526873", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LHE9-1", "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "Camk1d", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNASVSSNLSLASQKDCLAPSTLCSFLSSSSGVTGVGAERRPRPTTVTTGHTGSK", "length": 385 }, "evidence": [ { "id": "F1N063", "url": "https://omabrowser.org/oma/group/F1N063/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6AUH0-1", "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "Camk1d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNASVSSNLSLASQKDCLAPSTLCSFLSSSSGVAGVGAERRPRPTTVTTGHTGSK", "length": 385 }, "evidence": [ { "id": "F1N063", "url": "https://omabrowser.org/oma/group/F1N063/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XQX1-1", "protein_name": "Calcium/calmodulin dependent protein kinase ID", "gene_name": "CAMK1D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARENGDGGGSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEERASGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISESAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLHLGSSLDSTSASVSGTLSLATPLPDATTRKDCMSPSTLCSFVSSASSGVSAVGGDRRPRPTTVTTVHTGSK", "length": 393 }, "evidence": [ { "id": "F1N063", "url": "https://omabrowser.org/oma/group/F1N063/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q54CY9-1", "protein_name": "Probable myosin light chain kinase DDB_G0292624", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPIGDYELHKEIGKGAFSVVFLVTEKKTKKQWAMKIIDKKSSSKAALETEIEIMKKVDHPNIVKMHEYFESTDKIYLVVELVTGGPLFDRIVDKKSFTEKEAKLITQQLLQSLVYLHSIGIVHRDLKPENLLLKTPTDLTVALSDFGLSKIVGDDVFMKTTCGTPSYVAPEVLNNISNSPTAYSDAVDMWGVGVITYILLCGFPPFYSEDIRKLFESILSASYDFPNDYWGNVSKEAKHFINCLLTVEPTKRYSAKQALEHPWIIENNQTQPLPHWNDQIKKYMVIRRKESQKFGAELVWKPQAQTTNVKPTK", "length": 313 }, "evidence": [ { "id": "F1N063", "url": "https://omabrowser.org/oma/group/F1N063/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BW96-1", "protein_name": "Calcium/calmodulin-dependent protein kinase type 1D", "gene_name": "Camk1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNASVSSNLSLASQKDCLAPSTLCSFLSSSSGVAGVGAERRPRPTTVTTGHTGSK", "length": 385 }, "evidence": [ { "id": "F1N063", "url": "https://omabrowser.org/oma/group/F1N063/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IU85-1", "protein_name": "Calcium/calmodulin-dependent protein kinase type 1D", "gene_name": "CAMK1D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK", "length": 385 }, "evidence": [ { "id": "F1N063", "url": "https://omabrowser.org/oma/group/F1N063/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "calcium/calmodulin-dependent protein kinase activity", "id": "GO:0004683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004683", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulation of granulocyte chemotaxis", "id": "GO:0071622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071622", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis", "id": "GO:0050766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "regulation of neuron projection development", "id": "GO:0010975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "regulation of dendrite development", "id": "GO:0050773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050773", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "positive regulation of respiratory burst", "id": "GO:0060267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060267", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N063", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N063-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 385, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N063-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N063" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 279, "start_aa": "Phe", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.17", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17" }, { "id": "2.7.11.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.17" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 332, "end_pos": 334 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0L9-1", "uniprot_ac": "F1N0L9", "uniprot_id": "F1N0L9_BOVIN", "mass": { "chemical_mass": 145224.0, "monoisotopic_mass": 145224.0 }, "refseq": { "ac": "XP_002698903", "name": "myopalladin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698903" }, "gene_names": [ { "name": "MYPN", "type": "recommended", "evidence": [ { "id": "F1N0L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ] }, { "name": "MYPN", "type": "synonym", "evidence": [ { "id": "XP_002698903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698903" } ] } ], "protein_names": [ { "name": "Myopalladin", "type": "recommended", "evidence": [ { "id": "F1N0L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L9/entry#names_and_taxonomy" } ] }, { "name": "myopalladin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698903" } ] } ], "function": [ { "annotation": "Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9#function" }, { "database": "UniProtKB", "id": "ARBA00058480", "url": "https://www.uniprot.org/uniprotkb/ARBA00058480#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYPN", "url": "https://www.uniprot.org/uniprotkb/F1N0L9", "locus": { "chromosome": "28", "start_pos": 24679611, "end_pos": 24591033, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017509", "url": "https://www.ensembl.org/id/ENSBTAG00000017509" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017509", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017509", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20972", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20972", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527123", "url": "https://www.ncbi.nlm.nih.gov/gene/527123", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527123", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527123", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0L9", "url": "https://www.orthodb.org/?gene=F1N0L9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47633", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47633", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47633:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47633:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698903", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698903", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L9-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQDDSLEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPFHFGGSSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADEAQARKRFSSDQTKHSSISSFDPNFCQDNSQSPTNSKESLQETKRPQYSSEAQSKKVFLNKAADFIEELSSLFKAHSSKRIRPRACKNHKSKLESQNQVMQENSSSFPDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAAGEAASGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIIQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKDEMNRIQKPNEVSSPPTTSAGIPSAVPQTQHVVVQPRVSTIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLDVRGNEDLRNNGSLHSANSTTNLALTEQQPSPPNPEPPVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEESSEGGVVTTHQTRPDSFQERFNGQSAKISEPSSPVKEPPPVLAKPKLDSSQLQQLHNQVLLEQHHLQNPSPSSPKEFPFNMSVLNSTTVPAVTVSSKHAKAPPSQTFSLARPKHFFPSTSTTVASVSPSSSPVFTLSSTPQAMQRTMSKESLLVTHPSAQTKSLGGASIQNEPLPTPAPTEPAQLPLTFSISSGNQFQPRCVSPAPVSPTGRIQNPVAFLSSVLPSLPAIPPTNAMGLPKSAPSMPSQGLMKKNTKSSHPVSDDYIRETKNAVILDLGKKMNFSDVRSNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHFKMKREGDGTCSLHINSTSSDDDGNYTIMAANPQGRISCSGHLMVQGLPIRSRLTAAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDTSHKMLVRETGVHSLLIDPLTQRDAGTYTCIATNKTGQNSFSLELTVVAKEVKKAPVILEKLQNSGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMTVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL", "length": 1320, "header": "tr|F1N0L9-1|F1N0L9_BOVIN Isoform 1 of Myopalladin OS=Bos taurus OX=9913 GN=MYPN PE=3 SV=4 CANONICAL=F1N0L9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT3/entry", "sequence": { "sequence": "TLILQVKTSSIIDLPDSWTFLWITPMWYCEGKELENSPDIHIIQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKDEMNRIQKPNEVSSPPTTSAGIPSAVPQTQHVVVQPRVSTIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLDVRGNEDLRNNGSLHSANSTTNLALTEQQPSPPNPEPPVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEESSEGGVVTTHQTRPDSFQERFNGQSAKISEPSSPVKEPPPVLAKPKLDSSQLQQLHNQVLLEQHHLQNPSPSSPKEFPFNMSVLNSTTVPAVTVSSKHAKAPPSQTFSLARPKHFFPSTSTTVASVSPSSSPVFTLSSTPQAMQRTMSKESLLVTHPSAQTKSLGGASIQNEPLPTPAPTEPAQLPLTFSISSGNQFQPRCVSPAPVSPTGRIQNPVAFLSSVLPSLPAIPPTNAMGLPKSAPSMPSQGLMKKNTKSSHPVSDDYIRETKNAVILDLGKKMNFSDVRSNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHFKMKREGDGTCSLHINSTSSDDDGNYTIMAANPQGRISCSGHLMVQGLPIRSRLTAAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDTSHKMLVRETGVHSLLIDPLTQRDAGTYTCIATNKTGQNSFSLELTVVTAVFQGHPVRLECRVIGMPPPVFYWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMTVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL", "length": 1029, "header": "tr|A0AAA9SMT3-1|F1N0L9_BOVIN Computationally mapped isoform of Myopalladin OS=Bos taurus OX=9913 GN=MYPN PE=3 SV=1 CANONICAL=F1N0L9-1" }, "locus": { "chromosome": "28", "start_pos": 24679608, "end_pos": 24591033, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102674.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102674.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087666.1" } ] } }, { "isoform_ac": "F1N0L9-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L9/entry", "sequence": { "sequence": "MQDDSLEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPFHFGGSSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADEAQARKRFSSDQTKHSSISSFDPNFCQDNSQSPTNSKESLQETKRPQYSSEAQSKKVFLNKAADFIEELSSLFKAHSSKRIRPRACKNHKSKLESQNQVMQENSSSFPDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAAGEAASGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIIQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKDEMNRIQKPNEVSSPPTTSAGIPSAVPQTQHVVVQPRVSTIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLDVRGNEDLRNNGSLHSANSTTNLALTEQQPSPPNPEPPVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEESSEGGVVTTHQTRPDSFQERFNGQSAKISEPSSPVKEPPPVLAKPKLDSSQLQQLHNQVLLEQHHLQNPSPSSPKEFPFNMSVLNSTTVPAVTVSSKHAKAPPSQTFSLARPKHFFPSTSTTVASVSPSSSPVFTLSSTPQAMQRTMSKESLLVTHPSAQTKSLGGASIQNEPLPTPAPTEPAQLPLTFSISSGNQFQPRCVSPAPVSPTGRIQNPVAFLSSVLPSLPAIPPTNAMGLPKSAPSMPSQGLMKKNTKSSHPVSDDYIRETKNAVILDLGKKMNFSDVRSNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHFKMKREGDGTCSLHINSTSSDDDGNYTIMAANPQGRISCSGHLMVQGLPIRSRLTAAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDTSHKMLVRETGVHSLLIDPLTQRDAGTYTCIATNKTGQNSFSLELTVVAKEVKKAPVILEKLQNSGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMTVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL", "length": 1320, "header": "tr|F1N0L9-1|F1N0L9_BOVIN Isoform 1 of Myopalladin OS=Bos taurus OX=9913 GN=MYPN PE=3 SV=4 CANONICAL=F1N0L9-1" }, "locus": { "chromosome": "28", "start_pos": 24679608, "end_pos": 24602401, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023273.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023273.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023273.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023273.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 703, "start_aa": "Thr", "end_pos": 703, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr703", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 786, "start_aa": "Thr", "end_pos": 786, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr786", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:527123", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527123", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" }, { "name": "muscle alpha-actinin binding", "id": "GO:0051371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051371", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "F1N0L9", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1007, "end_pos": 1009, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1016, "end_pos": 1018, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1150, "end_pos": 1152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1209, "end_pos": 1211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 690, "end_pos": 692, "annotation": "n_glycosylation_sequon" }, { "start_pos": 695, "end_pos": 697, "annotation": "n_glycosylation_sequon" }, { "start_pos": 892, "end_pos": 894, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L9" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 269, "end_pos": 359, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 703, 786 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1007, "end_pos": 1009 }, { "start_pos": 1016, "end_pos": 1018 }, { "start_pos": 1150, "end_pos": 1152 }, { "start_pos": 1209, "end_pos": 1211 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 541, "end_pos": 543 }, { "start_pos": 548, "end_pos": 550 }, { "start_pos": 690, "end_pos": 692 }, { "start_pos": 695, "end_pos": 697 }, { "start_pos": 892, "end_pos": 894 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N045-1", "uniprot_ac": "F1N045", "uniprot_id": "F1N045_BOVIN", "mass": { "chemical_mass": 92990.0, "monoisotopic_mass": 92990.0 }, "refseq": {}, "gene_names": [ { "name": "C7", "type": "recommended", "evidence": [ { "id": "F1N045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ] } ], "protein_names": [ { "name": "Complement component C7", "type": "recommended", "evidence": [ { "id": "F1N045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N045/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LI40", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI40#function" }, { "database": "UniProtKB", "id": "ARBA00093281", "url": "https://www.uniprot.org/uniprotkb/ARBA00093281#function" }, { "database": "UniProtKB", "id": "A0AAA9ST78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST78#function" }, { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C7", "url": "https://www.uniprot.org/uniprotkb/F1N045", "locus": { "chromosome": "20", "start_pos": 33535895, "end_pos": 33592915, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011766", "url": "https://www.ensembl.org/id/ENSBTAG00000011766" } ] } } ], "crossref": [ { "id": "F1N045", "url": "https://alphafold.ebi.ac.uk/entry/F1N045", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011766", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011766", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CQNGGQP", "url": "https://omabrowser.org/oma/group/CQNGGQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LI40", "url": "https://www.orthodb.org/?gene=A0A3Q1LI40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N045", "url": "https://www.orthodb.org/?gene=F1N045", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45742:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45742:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01823", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01823", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21330", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21330", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-166665", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166665", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-977606", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LI40", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LI40-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N045-1", "url": "https://www.uniprot.org/uniprotkb/F1N045-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAITLLFLVGFIGEFQVFSSASSPINCQWGSYAPWSECNGCTKTQTRRRSIAVYGQYGGHSCVGSAFETQPCQPTRGCPTEDGCGERFRCFSGQCISKSLVCNGDSDCEEDGADEDRCEDAESRPACDKDKPPPNIELTGRGYNALTGQFRNQVLNTKSFGGQCRKVYSGDGRDFYRLSGNILSYTFQVKINNDFNNEFYNSTWAYVKETSTEHSSSSKGRFLFFSSSSSSHGYSSNTNILTKKKSYQLLVLQNTVEVAQFINNNPEFLQLAESFWKELSYLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYKVIFHMDSEKVKKFDFHSEDKRKCASSHFQFLFTSSKQKCTTMEEVLKSVSENEGNLLRGVPFVRGGHSGFLAGLSYLDLNNPAGNKRRYSQWAGSVPDLPEVIKQKLTPLYELVKEVPCASVKKLYLKRAIEEYLDEFDPCHCRPCHNGGMATVQGSQCQCYCKPKTSGVACEQGVLLGDQAGGVDGGWNCWSSWGPCVQGKKTRSRQCNNPSPSAGGKSCIGETSETRQCEDGELEHLRLLEPHCFPLSLVPTKFCSSPPALKDGFVQDEGATFPVGKNIMYTCKEGYSLVGDPVARCGEDLQWLVGNMHCQKIACVLPALMDGIQSHPHKPFYTIGEKVTISCSGGRSLEGPSTFLCSSSLKWSPEVKDVQCVQREAPLTPKVPKCQPWEKLQNSRCVCKMPYECGSSLGVCARDERSKRILPLTVCKMHVLQCQGRNYTVAGRESCTLPASAEKACGVCPLWEKCDAEGSECVCRAASECEEAGFSVCVEVNGREQTMTECEAGVLRCRGLSISVTGIRPCAAEAA", "length": 843, "header": "tr|F1N045-1|F1N045_BOVIN Isoform 1 of Complement component C7 OS=Bos taurus OX=9913 GN=C7 PE=3 SV=3 CANONICAL=F1N045-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LI40-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI40/entry", "sequence": { "sequence": "VYVFSLTFLSTQVGPCENFTRRRSIAVYGQYGGHSCVGSAFETQPCQPTRGCPTEDGCGERFRCFSGQCISKSLVCNGDSDCEEDGADEDRCEDAESRPACDKDKPPPNIELTGRGYNALTGQFRNQVLNTKSFGGQCRKVYSGDGRDFYRLSGNILSYTFQVKINNDFNNEFYNSTWAYVKETSTEHSSSSKGRFLFFSSSSSSHGYSSNTNILTKKKSYQLLVLQNTVEVAQFINNNPEFLQLAESFWKELSYLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYKVIFHMDSEKVKKFDFHSEDKRKCASSHFQFLFTSSKQKCTTMEEVLKSVSENEGNLLRGVPFVRGGHSGFLAGLSYLDLNNPAGNKRRYSQWAGSVPDLPEVIKQKLTPLYELVKEVPCASVKKLYLKRAIEEYLDEFDPCHCRPCHNGGMATVQGSQCQCYCKPKTSGVACEQGVLLGDQAGGVDGGWNCWSSWGPCVQGKKTRSRQCNNPSPSAGGKSCIGETSETRQCEDGELEHLRLLEPHCFPLSLVPTKFCSSPPALKDGFVQDEGATFPVGKNIMYTCKEGYSLVGDPVARCGEDLQWLVGNMHCQKIACVLPALMDGIQSHPHKPFYTIGEKVTISCSGGRSLEGPSTFLCSSSLKWSPEVKDVQCVQREAPLTPKVPKCQPWEKLQNSRCVCKMPYECGSSLGVCARDERSKRILPLTVCKMHVLQCQGRNYTVAGRESCTLPASAEKACGVCPLWEKCDAEGSECVCRAASECEEAGFSVCVEVNGREQTMTECEAGVLRCRGLSISVTGIRPCAAEAA", "length": 816, "header": "tr|A0A3Q1LI40-1|A0A3Q1LI40_BOVIN Computationally mapped isoform of Complement component C7 OS=Bos taurus OX=9913 GN=C7 PE=3 SV=2 CANONICAL=F1N045-1" }, "locus": { "chromosome": "20", "start_pos": 33585425, "end_pos": 33536945, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070246.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070246.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058588.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058588.2" } ] } }, { "isoform_ac": "A0AAA9ST78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST78/entry", "sequence": { "sequence": "MKAITLLFLVGFIGEFQVFSSASSPINCQWGSYAPWSECNGCTKTQTRRRSIAVYGQYGGHSCVGSAFETQPCQPTRGCPTEDGCGERFRCFSGQCISKSLVCNGDSDCEEDGADEDRCEDAESRPACDKDKPPPNIELTGRGCNSKPAVAIDTKECS", "length": 158, "header": "tr|A0AAA9ST78-1|F1N045_BOVIN Computationally mapped isoform of Complement component C7 OS=Bos taurus OX=9913 GN=C7 PE=3 SV=1 CANONICAL=F1N045-1" }, "locus": { "chromosome": "20", "start_pos": 33592845, "end_pos": 33577354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123390.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123390.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088554.1" } ] } }, { "isoform_ac": "F1N045-1", "url": "https://www.uniprot.org/uniprotkb/F1N045/entry", "sequence": { "sequence": "MKAITLLFLVGFIGEFQVFSSASSPINCQWGSYAPWSECNGCTKTQTRRRSIAVYGQYGGHSCVGSAFETQPCQPTRGCPTEDGCGERFRCFSGQCISKSLVCNGDSDCEEDGADEDRCEDAESRPACDKDKPPPNIELTGRGYNALTGQFRNQVLNTKSFGGQCRKVYSGDGRDFYRLSGNILSYTFQVKINNDFNNEFYNSTWAYVKETSTEHSSSSKGRFLFFSSSSSSHGYSSNTNILTKKKSYQLLVLQNTVEVAQFINNNPEFLQLAESFWKELSYLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYKVIFHMDSEKVKKFDFHSEDKRKCASSHFQFLFTSSKQKCTTMEEVLKSVSENEGNLLRGVPFVRGGHSGFLAGLSYLDLNNPAGNKRRYSQWAGSVPDLPEVIKQKLTPLYELVKEVPCASVKKLYLKRAIEEYLDEFDPCHCRPCHNGGMATVQGSQCQCYCKPKTSGVACEQGVLLGDQAGGVDGGWNCWSSWGPCVQGKKTRSRQCNNPSPSAGGKSCIGETSETRQCEDGELEHLRLLEPHCFPLSLVPTKFCSSPPALKDGFVQDEGATFPVGKNIMYTCKEGYSLVGDPVARCGEDLQWLVGNMHCQKIACVLPALMDGIQSHPHKPFYTIGEKVTISCSGGRSLEGPSTFLCSSSLKWSPEVKDVQCVQREAPLTPKVPKCQPWEKLQNSRCVCKMPYECGSSLGVCARDERSKRILPLTVCKMHVLQCQGRNYTVAGRESCTLPASAEKACGVCPLWEKCDAEGSECVCRAASECEEAGFSVCVEVNGREQTMTECEAGVLRCRGLSISVTGIRPCAAEAA", "length": 843, "header": "tr|F1N045-1|F1N045_BOVIN Isoform 1 of Complement component C7 OS=Bos taurus OX=9913 GN=C7 PE=3 SV=3 CANONICAL=F1N045-1" }, "locus": { "chromosome": "20", "start_pos": 33592845, "end_pos": 33536945, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056663.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056663.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047583.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047583.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-166665", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166665", "resource": "Reactome", "description": "Terminal pathway of complement" }, { "id": "R-BTA-977606", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "resource": "Reactome", "description": "Regulation of Complement cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YHT1-1", "protein_name": "Complement component C7", "gene_name": "C7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKMLGIFLLLEVSGFFPIFSSPSRPVNCHWNSFGPWSECDGCTHKQVRRRTVAVYGQYGGNPCSGDAFETRPCTPTRGCPTEDGCGDRFRCSSGQCISRSLVCNGDQDCEEDGTDEDQCEEKLTVCDTDKTPPNSELTGQGFDAVTGETRGRVIHTKNFGGQCRKVFSGDGREYYRLSESVLAYTFQVKIQNDFSYEFFNSSWSYMKHTEKKKKSNSGHSYSEKKNEQQSRKSRHLMVVENTVEVAQFINNNPEFLTLAEPFWKELANLPVFYDYSAYRRFIENFGTHFLHSGSLGGQYKVIFYMDTDKMKAEDMSITDMYQCTTSGWNFFIVKKKKTKCSKLDELLQTSSGSSGSKIRGDPYIEGGSPSAVAGLSYLDLDDPAGNNQRYSTWARSVTDYPRVIKQKLTPLYELVKEVPCSSVKKHYLKQSIEEYMAENDPCKCQPCQNGGEAAVEGTQCTCYCKPYTFGAACELGTLVQDQPGVVDGHWSCWSSWSSCSGERKARSRTCNNPSPSGGGKDCIGEQHESRPCEDEELQHFRFIEPHCFDTSITPTEFCSPPPVLANGFVRNAENSYPVGKTIVYACRHGYALIGNPVAKCGSNLEWQGGDRYCQETSCLLPLLEGGLQGEPWKPSYEIGERITLSCPHGMHLEGADSILCEPSLKWTPDMKTIQCKKAVPSVKPEVTEPKCQPWEKVQQSQCVCKLPYECGPSLDICATDPRTERSVHLTVCKMYALECMGRKYSLTNAANCKARQAAERSCGSCCSWEKCEARSNSCVCDEDAPCEEGGIRVCAAVSDFSAHQTMTECEVGRLQCRGQTVTIVSIRPCDAQTK", "length": 834 }, "evidence": [ { "id": "F1N045", "url": "https://omabrowser.org/oma/group/F1N045/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3YXF5-1", "protein_name": "Complement component C7", "gene_name": "C7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQVTSLLILVCFIAAFQVFSRASSPVNCKWDSYGPWSECNGCTKTQTRRRSVAVYGQYGGYPCEGSAFETQSCKPERGCPTEEGCGDRFRCFSGQCISKSLVCNGDPDCEEDGADEDKCENVANPSCNIDKPPPNIELTGYGYNVVTGQGKKRVINTKSFGGQCRKVFSGDGKDFYRLSGNILSYTFQVKVDNDFNYEFYNSSWSYIKHTSTEQNTFYSWKGLFSHSRNTYGHGSAKEEIDTKMKSYKLLVVQNTVEVAQFTNNNPEFLQVAEPFWKELSHLPTLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSGSAKETGFQSDQDNACSSADFQFLFTSSADQRCMKQLETEKSTSGNKGRLLRGKPLVRGGDSGFVADLSFLDLDNPAGNKQRYSSWAGSVTRLPQVIKEKLAPLYELVKEVPCASVKRLYLKRAIEEYFDEFDPCHCRPCQNGGLAIVVETQCQCLCKPYTFGSACEQGVLVGDQAGGVDGGWNCWSSWSPCVQGKRTRSRECNNPPPRDDGKSCLGETTESKQCEDQDLEKLRLLEPHCFHSSLAPKEFCLSPPALKDGFVQGEGTMVPVGQSVVYACDEGYSLIGDPVARCGEDLQWLVGEMHCQKLACVLPGEMNGMQSHPQKPFYMVGEKVTLSCVGGMSLEGPSTLLCGSSLKWSPELKDAKCVQKATSTPPPAAPACQPWEKLQNSKCICKMPYECGSSLDVCARDESRNKILSLTICKMHVVHCHKRNYTLVGKESCTLPSPAEKVCGACPIWSKCDAQNGKCICREASECQTAGYRICVEVNGKEETMSECEAGILRCRGQSISITAIKPCAEEAAQ", "length": 845 }, "evidence": [ { "id": "F1N045", "url": "https://omabrowser.org/oma/group/F1N045/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P10643-1", "protein_name": "Complement component C7", "gene_name": "C7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWGKCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAAETQ", "length": 843 }, "evidence": [ { "id": "F1N045", "url": "https://omabrowser.org/oma/group/F1N045/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "membrane attack complex", "id": "GO:0005579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005579", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "other organism cell membrane", "id": "GO:0044218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044218", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "killing of cells of another organism", "id": "GO:0031640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "complement activation, classical pathway", "id": "GO:0006958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "complement activation, GZMK pathway", "id": "GO:0160257", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160257", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" }, { "name": "complement activation", "id": "GO:0006956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006956", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "wide pore channel activity", "id": "GO:0022829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022829", "evidence": [ { "database": "UniProtKB", "id": "F1N045", "url": "https://www.uniprot.org/uniprotkb/F1N045" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 754, "end_pos": 756, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N045-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 843, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N045-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N045" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N045" }, { "id": "PS51412", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51412" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MACPF", "eco_id": "ECO_0000259", "start_pos": 124, "end_pos": 456, "start_aa": "Ser", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N045" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 569, "end_pos": 628, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 }, { "start_pos": 754, "end_pos": 756 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N009-1", "uniprot_ac": "F1N009", "uniprot_id": "F1N009_BOVIN", "mass": { "chemical_mass": 44805.0, "monoisotopic_mass": 44805.0 }, "refseq": {}, "gene_names": [ { "name": "OAS1X", "type": "recommended", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ] } ], "protein_names": [ { "name": "2'-5' oligoadenylate synthase", "type": "recommended", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.84", "type": "synonym", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OAS1X", "url": "https://www.uniprot.org/uniprotkb/F1N009", "locus": {} } ], "crossref": [ { "id": "F1N009", "url": "https://alphafold.ebi.ac.uk/entry/F1N009", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037527", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037527", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11258:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11258:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "34407", "url": "https://www.rhea-db.org/rhea/34407", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9STM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N009-1", "url": "https://www.uniprot.org/uniprotkb/F1N009-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVELSDTPAESLDKFIEDHLLSNEEFRTQVKQAIDIICTFLKERCFRCAPHRVSKVVKGGSSGKGTTLRGRSDADLVVFLTNLTSFREQLERRGEFIEEIRRQLEACQREKTFEVKFEVQKRQWENPRALSFVLRSPKLDQEVEFDVLPAFDALGQLTKGYRPDPQIYVKLIQECENQRREGEFSPCFTELQRDFLKERPAKLKSLIRLVKHWYQLCKMKHKNNLPPQYALELLTVYAWEQGSAKPEFSTAQGFRTVLELILKHQDLCIYWKKYYDTENSIIRQYLKKQLAKPRPVILDPADPTGNVAGREPQRWHWLAHEVRYWLSYSCCTNLNGMPVSTWNVPHKHQLRTYKDLNTGAETVKLLEENTGGKLHDIDLAMTL", "length": 383, "header": "tr|F1N009-1|F1N009_BOVIN Isoform 1 of 2'-5' oligoadenylate synthase OS=Bos taurus OX=9913 GN=OAS1X PE=3 SV=2 CANONICAL=F1N009-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM9/entry", "sequence": { "sequence": "MVELSDTPAESLDKFIEDHLLSNEEFRTQVKQAIDIICTFLKERCFRCAPHRVSKVVKGGSSGKGTTLRGRSDADLVVFLTNLTSFREQLERRGEFIEEIRRQLEACQREKTFEVKFEVQKRQWENPRALSFVLRSPKLDQEVEFDVLPAFDALGECSQLLPLSFLVSEQKCLSL", "length": 175, "header": "tr|A0AAA9STM9-1|F1N009_BOVIN Computationally mapped isoform of 2'-5' oligoadenylate synthase OS=Bos taurus OX=9913 GN=OAS1X PE=3 SV=1 CANONICAL=F1N009-1" }, "locus": { "chromosome": "17", "start_pos": 61385090, "end_pos": 61383720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121729.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121729.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087493.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087493.1" } ] } }, { "isoform_ac": "F1N009-1", "url": "https://www.uniprot.org/uniprotkb/F1N009/entry", "sequence": { "sequence": "MVELSDTPAESLDKFIEDHLLSNEEFRTQVKQAIDIICTFLKERCFRCAPHRVSKVVKGGSSGKGTTLRGRSDADLVVFLTNLTSFREQLERRGEFIEEIRRQLEACQREKTFEVKFEVQKRQWENPRALSFVLRSPKLDQEVEFDVLPAFDALGQLTKGYRPDPQIYVKLIQECENQRREGEFSPCFTELQRDFLKERPAKLKSLIRLVKHWYQLCKMKHKNNLPPQYALELLTVYAWEQGSAKPEFSTAQGFRTVLELILKHQDLCIYWKKYYDTENSIIRQYLKKQLAKPRPVILDPADPTGNVAGREPQRWHWLAHEVRYWLSYSCCTNLNGMPVSTWNVPHKHQLRTYKDLNTGAETVKLLEENTGGKLHDIDLAMTL", "length": 383, "header": "tr|F1N009-1|F1N009_BOVIN Isoform 1 of 2'-5' oligoadenylate synthase OS=Bos taurus OX=9913 GN=OAS1X PE=3 SV=2 CANONICAL=F1N009-1" }, "locus": { "chromosome": "17", "start_pos": 61385090, "end_pos": 61375617, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044986.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044986.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042418.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042418.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "nucleotidyltransferase activity", "id": "GO:0016779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "2'-5'-oligoadenylate synthetase activity", "id": "GO:0001730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001730", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "interleukin-27-mediated signaling pathway", "id": "GO:0070106", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070106", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "negative regulation of viral genome replication", "id": "GO:0045071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "type I interferon-mediated signaling pathway", "id": "GO:0060337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060337", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N009", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "34407", "name": "", "equation": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SAL0-1", "F1N009-1", "F1MV66-1", "F1N3B8-1" ], "evidence": [ { "id": "34407", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34407" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SAL0", "gene_name": "OAS1Z", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ] } ] }, { "uniprot_ac": "F1MV66", "gene_name": "OAS1Y", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "F1MV66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV66" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "F1MV66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV66" } ] } ] }, { "uniprot_ac": "F1N009", "gene_name": "OAS1X", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ] } ] }, { "uniprot_ac": "F1N3B8", "gene_name": "OAS2", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "F1N3B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B8" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "F1N3B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N009-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 383, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N009-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N009" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" }, { "id": "PF10421", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10421" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "2'-5'-oligoadenylate synthetase 1", "eco_id": "ECO_0000259", "start_pos": 162, "end_pos": 346, "start_aa": "Arg", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" }, { "id": "PF01909", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01909" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Polymerase nucleotidyl transferase", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 125, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.84", "ec_name": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "2.7.7.84", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84" }, { "id": "2.7.7.84", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.84" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Q2-1", "uniprot_ac": "F1N0Q2", "uniprot_id": "F1N0Q2_BOVIN", "mass": { "chemical_mass": 256130.0, "monoisotopic_mass": 256130.0 }, "refseq": { "ac": "NP_001179852", "name": "A-kinase anchor protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179852" }, "gene_names": [ { "name": "AKAP6", "type": "recommended", "evidence": [ { "id": "F1N0Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ] }, { "name": "AKAP6", "type": "synonym", "evidence": [ { "id": "NP_001179852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179852" } ] } ], "protein_names": [ { "name": "A-kinase anchor protein 6", "type": "recommended", "evidence": [ { "id": "F1N0Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2/entry#names_and_taxonomy" } ] }, { "name": "A kinase (PRKA) anchor protein 6", "type": "synonym", "evidence": [ { "id": "NP_001179852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179852" } ] }, { "name": "A-kinase anchor protein 6", "type": "synonym", "evidence": [ { "id": "NP_001179852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179852" } ] }, { "name": "Protein kinase A-anchoring protein 6", "type": "synonym", "evidence": [ { "id": "F1N0Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2/entry#names_and_taxonomy" } ] }, { "name": "mAKAP", "type": "synonym", "evidence": [ { "id": "F1N0Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW39#function" }, { "database": "UniProtKB", "id": "ARBA00059890", "url": "https://www.uniprot.org/uniprotkb/ARBA00059890#function" }, { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKAP6", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2", "locus": { "chromosome": "21", "start_pos": 43212928, "end_pos": 42623917, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017719", "url": "https://www.ensembl.org/id/ENSBTAG00000017719" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017719", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017719", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00176", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00176", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537810", "url": "https://www.ncbi.nlm.nih.gov/gene/537810", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537810", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537810", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INCPPIR", "url": "https://omabrowser.org/oma/group/INCPPIR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14514", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14514", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14514:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14514:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SW39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Q2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTMSVTLSPLRSQDLDPMATDASPMAINLTPTVEQGGGEEVMRGMDPDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDALTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLSVAPDSVPSNFSEAVSEEASQVSLSADDTGRSEENNACTVEEQPGLMQGPSSSVEAPTNAVQPASEAVKQESDSSSQHGAKNPQPLACENTTPKRSIRDCFNYNEDSPTQPTLPKRGFFLKDETVKNNLKGPSGKKQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKMGDGNLENTVRSHIKEISSSLGRLNDCHKEKLRLKKPHKTGEEMPPCQTPKQEPSSDKQAKNTRSATVPNAIPSSPSKARQRPEAESASTSSLEPCHQSSGNAKLPVQSETSSSPPFTQSSESSASSDSVTSLGPLLSEHKGKSSYSSSPSHITRNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETVQNIDDWELSEMNSDSEMYPTYHVKKKHTRLGRVSPSSSSDIASSLGESVESGPLSDLLSDEELGMPLSGMKKYADEKSERVSSSEKNESHSAAKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEGEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSGGGNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRDLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKVQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNAEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESEALNVIDPGLMDLNGTSEDALEWDETDISNKLISLNEELNDLDQESQPAMPSLNLKETDSENPSYEEEAGGHGASQFASSITAPSSPHVYQVYSLHNVELYEDSHIPFLKNNPKFTSMTQPSVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCPCHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNAVDGSPSNPDTEHLDPQMGDAVNVLKQKIKDEEERIKLPNSSQLPISPVGCVNGKVGDLNSVTKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLHGFYFDKKSCKSKHQATELQPDAPPHERILASAPHEMDRSSYKSGDVEKTFTGMQNARQLSLLSHSSSIESLSPGGDLFALGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDLSVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSCSQKMSFPGQLSLDMASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNVSFRKRLPRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCVKDEDDDSSIATDDEIYEDCNVMSGLDYIKNELQTWIRPKLSLTRDKRRCNLSDEIKGNKDVSSSEMTNSSDTLNIETLLNGSIKHLSENNGNSKNLPHTRELGTKGENKKNIFTVNKDPYVADMENGNIESIPESQKDKLNEISKESESFGSAGKRISESEHCKCKPVMDGSDESDIAGKESVPQMARHVPKKCQSHHHFENQSAASTPTEKSCPELPSETSVINGQDSNVLKSSSNNAPSMAGKPAGCCLAREQNETEENVAASDNVSCCDCEPDIFHQKDAEDCSVHDFVKEIIGMASTALKCKSQPENEVTAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPTDMTDSGSEDKEDTEYFFEACVEEDPAEDKPCFSDVPPNEPADPTEAAVPLLAGAGSSRFSDTSLLASNADMVALSSPPKGGDVGKEVDSLPEASNVHGESAEVTTPSRLGSEKESSENPGESARPEEHSASSAPSGVPRLSSKAKQPKDKAAWHPSPTALTCEENLLNLQEERHRNMHR", "length": 2319, "header": "tr|F1N0Q2-1|F1N0Q2_BOVIN Isoform 1 of A-kinase anchor protein 6 OS=Bos taurus OX=9913 GN=AKAP6 PE=4 SV=2 CANONICAL=F1N0Q2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW39/entry", "sequence": { "sequence": "MKKTWKQIKGKRKIAPVLLNGDLLRLQLEPVLWISPLAALQEDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDALTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLSVAPDSVPSNFSEAVSEEASQVSLSADDTGRSEENNACTVEEQPGLMQGPSSSVEAPTNAVQPASEAVKQESDSSSQHGAKNPQPLACENTTPKRSIRDCFNYNEDSPTQPTLPKRGFFLKDETVKNNLKGPSGKKQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKMGDGNLENTVRSHIKEISSSLGRLNDCHKEKLRLKKPHKTGEEMPPCQTPKQEPSSDKQAKNTRSATVPNAIPSSPSKARQRPEAESASTSSLEPCHQSSGNAKLPVQSETSSSPPFTQSSESSASSDSVTSLGPLLSEHKGKSSYSSSPSHITRNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETVQNIDDWELSEMNSDSEMYPTYHVKKKHTRLGRVSPSSSSDIASSLGESVESGPLSDLLSDEELGMPLSGMKKYADEKSERVSSSEKNESHSAAKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEGEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSGGGNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRDLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKVQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNAEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESEALNVIDPGLMDLNGTSEDALEWDETDISNKLISLNEELNDLDQESQPAMPSLNLKETDSENPSYEEEAGGHGASQFASSITAPSSPHVYQVYSLHNVELYEDSHIPFLKNNPKFTSMTQPSVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCPCHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNAVDGSPSNPDTEHLDPQMGDAVNVLKQKIKDEEERIKLPNSSQLPISPVGCVNGKVGDLNSVTKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLHGFYFDKKSCKSKHQATELQPDAPPHERILASAPHEMDRSSYKSGDVEKTFTGMQNARQLSLLSHSSSIESLSPGGDLFALGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDLSVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSCSQKMSFPGQLSLDMASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNVSFRKRLPRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCVKDEDDDSSIATDDEIYEDCNVMSGLDYIKNELQTWIRPKLSLTRDKRRCNLSDEIKGNKDVSSSEMTNSSDTLNIETLLNGSIKHLSENNGNSKNLPHTRELGTKGENKKNIFTVNKDPYVADMENGNIESIPESQKDKLNEISKESESFGSAGKRISESEHCKCKPVMDGSDESDIAGKESVPQMARHVPKKCQSHHHFENQSAASTPTEKSCPELPSETSVINGQDSNVLKSSSNNAPSMAGKPAGCCLAREQNETEENVAASDNVSCCDCEPDIFHQKDAEDCSVHDFVKEIIGMASTALKCKSQPENEVTAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPTDMTDSGSEDKEDTEYFFEACVEEDPAEDKPCFSDVPPNEPADPTEAAVPLLAGAGSSRFSDTSLLASNADMVALSSPPKGGDVGKEVDSLPEASNVHGESAEVTTPSRLGSEKESSENPGESARPEEHSASSAPSGVPRLSSKAKQPKDKAAWHPSPTALTCEENLLNLQEERHRNMHR", "length": 2253, "header": "tr|A0AAA9SW39-1|F1N0Q2_BOVIN Computationally mapped isoform of A-kinase anchor protein 6 OS=Bos taurus OX=9913 GN=AKAP6 PE=4 SV=1 CANONICAL=F1N0Q2-1" }, "locus": { "chromosome": "21", "start_pos": 43206405, "end_pos": 42624116, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095081.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095081.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087434.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087434.1" } ] } }, { "isoform_ac": "F1N0Q2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2/entry", "sequence": { "sequence": "MLTMSVTLSPLRSQDLDPMATDASPMAINLTPTVEQGGGEEVMRGMDPDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDALTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLSVAPDSVPSNFSEAVSEEASQVSLSADDTGRSEENNACTVEEQPGLMQGPSSSVEAPTNAVQPASEAVKQESDSSSQHGAKNPQPLACENTTPKRSIRDCFNYNEDSPTQPTLPKRGFFLKDETVKNNLKGPSGKKQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKMGDGNLENTVRSHIKEISSSLGRLNDCHKEKLRLKKPHKTGEEMPPCQTPKQEPSSDKQAKNTRSATVPNAIPSSPSKARQRPEAESASTSSLEPCHQSSGNAKLPVQSETSSSPPFTQSSESSASSDSVTSLGPLLSEHKGKSSYSSSPSHITRNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETVQNIDDWELSEMNSDSEMYPTYHVKKKHTRLGRVSPSSSSDIASSLGESVESGPLSDLLSDEELGMPLSGMKKYADEKSERVSSSEKNESHSAAKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEGEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSGGGNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRDLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKVQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNAEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESEALNVIDPGLMDLNGTSEDALEWDETDISNKLISLNEELNDLDQESQPAMPSLNLKETDSENPSYEEEAGGHGASQFASSITAPSSPHVYQVYSLHNVELYEDSHIPFLKNNPKFTSMTQPSVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCPCHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNAVDGSPSNPDTEHLDPQMGDAVNVLKQKIKDEEERIKLPNSSQLPISPVGCVNGKVGDLNSVTKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLHGFYFDKKSCKSKHQATELQPDAPPHERILASAPHEMDRSSYKSGDVEKTFTGMQNARQLSLLSHSSSIESLSPGGDLFALGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDLSVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSCSQKMSFPGQLSLDMASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNVSFRKRLPRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCVKDEDDDSSIATDDEIYEDCNVMSGLDYIKNELQTWIRPKLSLTRDKRRCNLSDEIKGNKDVSSSEMTNSSDTLNIETLLNGSIKHLSENNGNSKNLPHTRELGTKGENKKNIFTVNKDPYVADMENGNIESIPESQKDKLNEISKESESFGSAGKRISESEHCKCKPVMDGSDESDIAGKESVPQMARHVPKKCQSHHHFENQSAASTPTEKSCPELPSETSVINGQDSNVLKSSSNNAPSMAGKPAGCCLAREQNETEENVAASDNVSCCDCEPDIFHQKDAEDCSVHDFVKEIIGMASTALKCKSQPENEVTAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPTDMTDSGSEDKEDTEYFFEACVEEDPAEDKPCFSDVPPNEPADPTEAAVPLLAGAGSSRFSDTSLLASNADMVALSSPPKGGDVGKEVDSLPEASNVHGESAEVTTPSRLGSEKESSENPGESARPEEHSASSAPSGVPRLSSKAKQPKDKAAWHPSPTALTCEENLLNLQEERHRNMHR", "length": 2319, "header": "tr|F1N0Q2-1|F1N0Q2_BOVIN Isoform 1 of A-kinase anchor protein 6 OS=Bos taurus OX=9913 GN=AKAP6 PE=4 SV=2 CANONICAL=F1N0Q2-1" }, "locus": { "chromosome": "21", "start_pos": 43206405, "end_pos": 42827429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023566.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023566.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023566.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023566.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537810", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537810", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E9Q9K8-1", "protein_name": "A-kinase anchor protein 6", "gene_name": "Akap6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLTMSVTLSPLRSQDPDPMATDASPMAINMTPTVEQEEGEGEEAVKDVGAEQQYGKPPPLHTAADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDADSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETTEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLGGLGDMTTSQAKTKSFDSWSYSEMEKEFPELIRSVGLLTVATEPVPSSCGAANEDSSQVILSEDHRGGHEEDGALEPGEQLGSTLETSSLGDTLTNAAEHPPETANQDSTSSPQLGAKKSQPGPCEMMTPKRSIRDCFNYNEDSPTQPTLPKRGLFLKETLKNERRGSDGKGRVVDLKPELSRSTPSLVEPPDRSKLCLVLQSSYPSSPSAASQSYECLHKVGIGNLENIVRSHIKEISSSLGRLTDCHKEKPRLKKPHKTLAEVSLCKIPKRGTGSGKQSENTRSSVVPTMVSPGAPKATARPATDSASTTSGDTCHQRNRGGKLPAQSKASSSSPCSHSSESSLGSDNIKSPLPLLSKSQKGSPPAPCHATQNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETIQDIDDWELSEMNSDSEIYPTYHIKKKHTRLGTVSPSSSSDIASSLGESIESGPLSDILSDEDLCMPLSGMKKFTDEKSERPSSSEKNESHSATKSALIQKLMKDIQHQDNYEAIWERIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLRLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLKMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEAQLCYLEAQRDAVEQMSLKLYSEQYTSGSKRKEEFADMSKAHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGLSLPNDILEKVDSINEKWELLGKTLREKIQDTMAGHSGSGPRDLLSPESGSLVRQLEVRIKELKRWLRDTELFIFNSCLRQEKEGTSAEKQLQYFKSLCHEIKQRRRGVASILRLCQHLLDDRDTCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLRKKMGKESETLNVIDPGLMDLNGMSEDALEWDETDISNKLISVHEESNDLDQDLEPMVPTVKLEETHHKDSGYEEEAGDCGGSQYTSNITAPSSPHIYQVYSLHNVEFHEDSHTQFLKSSPKFTGTVQPTVLTKSLSKDSSFSSTKSLPDLLGGSSLVRPYSCQSGDLSQNSGSESGIVSEGDNEMPTNSDMSLFSMVDGSPSNPETQHLDPQMGDAANVLEQKFKDEGECIKLSSVSQASVSPVGCVNGKAGDLNSITKHTTDCLGDELQGKHEVFTFYDYSYLQGSKLKFPMIMKQPQSEKAHLEDPLLRGFYFDKKSCKPKHQTSESQPDAPLHEKILASAPHEMGRSSYKSSDIEKALTGIQNARQLSLLSRSSSVESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFSGQMSLDVASSINEDSPASLTELSSSDELSLCSEDIVLHKNKVPESNASFRKRLNRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCLKDEDDDSSIATDDEIYEESNLMSGLDYIKNELQTWIRPKLSLSREKKRPSVTDEIKVNKDGGSTERANPSDTLDIEALLNCSIKRLSENNGNGKNPPRTHDLGTKGENKKNTYDVTKDPHVADMENGNVESTPEREKEKPEIPEASANLASNVKKISESKHDEYEALMDGSDDSSVTGKEFGPPNDRHPPQIGADPQHPERGDCTSVQNSCSGLLLETGGGSRQDSDGLKSLSNDAPSVARNAAGCCLLEQNETEESASISSSTSCCNCKPDVFHQKDDEDCSVHDFVKEIIDMASTALKSKSQPESEVAAPTSLTQIKEKVLEHSHRPIHLRKGDFYSYLSLSSHDSDCGEVTNYIDEKSNTPLPPDTVDSGLDDKEDVDCFFEACVEDEPADEEARLSSALPNESEVQDEAAKPEQMTASSSVFRDETDTVPLSGLSPQKGADDAKEGDGASHTSQGCVESAEPTTPPGKAKREGSSRKQSVSGTPEENAASAKPKIQAFSLNAKQPKGKAALYPSPQTLTCKEKLVSFHEDRHSNMHR", "length": 2307 }, "evidence": [ { "id": "F1N0Q2", "url": "https://omabrowser.org/oma/group/F1N0Q2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3L6S3-1", "protein_name": "A-kinase anchor protein 6", "gene_name": "AKAP6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLTMSVTLSPLRSQDLDPMATDASPMAINLTPTVEQVEGEEVMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDALTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVATDPIPSNCSEAVGEEASQVSLSADDRGGCEENNASAVEEQSGLTQELSSSGEALKKGAPPSVETVKQDSVSSSQLGAKNQQPLPCENATPKRSIRDCFNYNEDSPTQPTLPKRGLFLKEETLKNNLKGTSVKKQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSPYPNSPSAASQSYECLHKMGVENLENTVKSYIKEISSSLGRLNNCHKEKPPLKKPHKTPKEVPPCQTPKREPSSGKQAKNIRSSVVLNGIPSCPSKATEGPETDSASTSSLEPCNQSSWNAKVPVRSETSSSPPFTQSSESSVGSDNITSPEPFLSEHKGKTSLSSSPSHVTRNGQVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETLQNIDDWELSEMNSDSEIYPTYHVKKKHMRLGRVSPSSSSDIASSLGESIESGPLSDLLSDEELGLPLSGMKRYTDEKSERASSSEKKESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDGLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSAEGEEGTESPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGGNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRDLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSGPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNAEKQLQYFKSLCCEIKQRRRGVASILRLCQHLLDDRETCNVNPDHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGYMDLNGTSEDALEWDETDISNKLISLNEESNDLDQESQPVMPSLKLEETGSEDPSYEGEAGDHGAAQYASSITAPSSPHIYQVYSLHNVELYEDNHIPFLKNSPKFTGMTQPSVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCPCHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNVVDGSPSNPETEHLDPQMGDAVNMLKQKFKEEGDQIKLPNSSQLSISPVSCVNGKVEDLNSVTKHTPDCLGDELQGKHDVFTFYDYSYLQGSKLRLPMIMKQSQNEKAHVEDPLLHGFYFDKKSCKSKHQATELQPDAPPHERILASAAHEMDRNSYKSGEVEKTLTGMQNARQLSLLSHSSSIESLSPGGDLFALGIFKNGTDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQLSLDIASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEECNLISGLDYIKNELQTWIRPKFSLTRDKRRCSVSDEIRGSKDVSSSEMTDSSDTLNIEALLNGSIKHLSENNGNGKNLLHTRELGTKGENKKNIFKVNKDPYVADMENGNIESTSERQDKMNEIPKESENLGSTGKRIPESEHCKCKAFMDSSDDSNIAIKDSLPQTIRHLPKKCQKYHHFENQSTASPPTEKSYPELPSKTSAINRQDADVLKSSSTDAPNVAEKSADCCLAVEQNETEGNVSTGDHFSCCDCEPDVFHQKDAEDGSVHDFVKEIIDMASTALKCKSQPENEVAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTSYVEEKSNTPLPPDMTDSGSEDKEDTECFFEACVEDNPDEDKPCFSSAPPNETAVPGEAPGPLQAAAGSSEFSNTPLLADHADIVALSSPPLPQGGGVGQEVDGAPQASNVCGKSSELTTPSRIGSEKESSENPGESGMPEEHNASSTRSGVPELSSKAQQPKDKAAVHPDPQTLTCEENLLDLHEERHRNMHR", "length": 2320 }, "evidence": [ { "id": "F1N0Q2", "url": "https://omabrowser.org/oma/group/F1N0Q2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q13023-1", "protein_name": "A-kinase anchor protein 6", "gene_name": "AKAP6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQPVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKAIEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPGYDEEADNHGGSQYASNITAPSSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKVGDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLRGFYFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLSLLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSINEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENNGNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENLGSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPTEKSFSELALETRFNNRQDSDALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCNCEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACVEGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQERAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDLSLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR", "length": 2319 }, "evidence": [ { "id": "F1N0Q2", "url": "https://omabrowser.org/oma/group/F1N0Q2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WVC7-1", "protein_name": "A-kinase anchor protein 6", "gene_name": "Akap6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLTMSVTLSPLRSQGPDPMATDASPMAINMTPTVEQEEGEGEEAVKAIDAEQQYGKPPPLHTAADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDADSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETTEGRLDSLTEVDDSGQLTIKCSQDYLSLDCGITAFELSDYSPSEDLLGGLGDMTTSQAKTKSFDSWSYSEMEKEFPELIRSVGLLTVATEPVPSSCGEANEDSSQASLSDDHKGEHGEDGAPVPGQQLDSTVGMSSLDGTLANAAEHPSETAKQDSTSSPQLGAKKTQPGPCEITTPKRSIRDCFNYNEDSPTQPTLPKRGLFLKETQKNERKGSDRKGQVVDLKPELSRSTPSLVDPPDRSKLCLVLQSSYPSSPSAASQSYECLHKVGLGNLENIVRSHIKEISSSLGRLTDCHKEKLRLKKPHKTLAEVSLCRIPKQGGGSGKRSESTGSSAGPSMVSPGAPKATMRPETDSASTASGGLCHQRNRSGQLPVQSKASSSPPCSHSSESSLGSDSIKSPVPLLSKNKSQKSSPPAPCHATQNGQVVEAWYGSDEYLALPSHLKQTEVLALKLESLTKLLPQKPRGETIQDIDDWELSEMNSDSEIYPTYHIKKKHTRLGTVSPSSSSDIASSLGESIESGPLSDILSDEDLCLPLSSVKKFTDEKSERPSSSEKNESHSATRSALIQKLMHDIQHQENYEAIWERIEGFVNKLDEFIQWLNEAMETTENWTPPKAETDSLRLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELVVSHKAGLKDTLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCHLETQRDAVEQMSLKLYSEQYTSGSKRKEEFANMSKAHAEGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKSELLSKVEALKKGGLSLPDDILEKVDSINEKWELLGKTLREKIQDTIAGHSGSGPRDLLSPESGSLVRQLEVRIKELKRWLRDTELFIFNSCLRQEKEGTSAEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRDTCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWDETDISNKLISVHEESNDLDQDPEPMLPAVKLEETHHKDSGYEEEAGDCGGSPYTSNITAPSSPHIYQVYSLHNVELHEDSHTPFLKSSPKFTGTTQPTVLTKSLSKDSSFSSTKSLPDLLGGSGLVRPYSCHSGDLSQNSGSESGIVSEGDNEMPTNSDMSLFSMVDGSPSNPETEHPDPQMGDAANVLEQKFKDNGESIKLSSVSRASVSPVGCVNGKAGDLNSVTKHTADCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQPQSEKAHVEDPLLGGFYFDKKSCKAKHQASESQPDAPPHERILASAPHEMGRSAYKSSDIEKTFTGIQSARQLSLLSRSSSVESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDMTLQSSSQKMPFAGQMSLDVASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLNRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCLKDEDDDSSIATDDEIYEESNLMSGLDYIKNELQTWIRPKLSLTREKKRSGVTDEIKVNKDGGGNEKANPSDTLDIEALLNGSIRCLSENNGNGKTPPRTHGSGTKGENKKSTYDVSKDPHVADMENGNIESTPEREREKPQGLPEVSENLASNVKTISESELSEYEAVMDGSEDSSVARKEFCPPNDRHPPQMGPKLQHPENQSGDCKPVQNPCPGLLSEAGVGSRQDSNGLKSLPNDAPSGARKPAGCCLLEQNETEESASISSNASCCNCKPDVFHQKDDEDCSVHDFVKEIIDMASTALKSKSQPESEVAAPTSLTQIKEKVLEHSHRPIHLRKGDFYSYLSLSSHDSDCGEVTNYIDEKSSTPLPPDAVDSGLDDKEDMDCFFEACVEDEPVNEEAGLPGALPNESAIEDGAEQKSEQKTASSPVLSDKTDLVPLSGLSPQKGADDAKEGDDVSHTSQGCAESTEPTTPSGKANAEGRSRMQGVSATPEENAASAKPKIQAFSLNAKQPKGKVAMRYPSPQTLTCKEKLVNFHEDRHSNMHR", "length": 2314 }, "evidence": [ { "id": "F1N0Q2", "url": "https://omabrowser.org/oma/group/F1N0Q2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "sarcoplasmic reticulum", "id": "GO:0016529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016529", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "calcium channel complex", "id": "GO:0034704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034704", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "cytoskeleton-nuclear membrane anchor activity", "id": "GO:0140444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140444", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of cation transmembrane transport", "id": "GO:1904064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904064", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "regulation of metal ion transport", "id": "GO:0010959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010959", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "regulation of relaxation of cardiac muscle", "id": "GO:1901897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901897", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "regulation of membrane repolarization", "id": "GO:0060306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060306", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "id": "GO:0010880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010880", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" }, { "name": "positive regulation of potassium ion transmembrane transport", "id": "GO:1901381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901381", "evidence": [ { "database": "UniProtKB", "id": "F1N0Q2", "url": "https://www.uniprot.org/uniprotkb/F1N0Q2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1209, "end_pos": 1211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1423, "end_pos": 1425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1584, "end_pos": 1586, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1714, "end_pos": 1716, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1732, "end_pos": 1734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1738, "end_pos": 1740, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1819, "end_pos": 1821, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1837, "end_pos": 1839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1849, "end_pos": 1851, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1971, "end_pos": 1973, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2025, "end_pos": 2027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2036, "end_pos": 2038, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 648, "end_pos": 650, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 803, "end_pos": 805, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1209, "end_pos": 1211 }, { "start_pos": 1423, "end_pos": 1425 }, { "start_pos": 1584, "end_pos": 1586 }, { "start_pos": 1714, "end_pos": 1716 }, { "start_pos": 1732, "end_pos": 1734 }, { "start_pos": 1738, "end_pos": 1740 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 1819, "end_pos": 1821 }, { "start_pos": 1837, "end_pos": 1839 }, { "start_pos": 1849, "end_pos": 1851 }, { "start_pos": 1971, "end_pos": 1973 }, { "start_pos": 2025, "end_pos": 2027 }, { "start_pos": 2036, "end_pos": 2038 }, { "start_pos": 285, "end_pos": 287 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 365, "end_pos": 367 }, { "start_pos": 648, "end_pos": 650 }, { "start_pos": 749, "end_pos": 751 }, { "start_pos": 803, "end_pos": 805 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0K4-1", "uniprot_ac": "F1N0K4", "uniprot_id": "F1N0K4_BOVIN", "mass": { "chemical_mass": 26854.0, "monoisotopic_mass": 26854.0 }, "refseq": { "ac": "XP_005208908", "name": "tumor necrosis factor ligand superfamily member 14 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208908" }, "gene_names": [ { "name": "TNFSF14", "type": "recommended", "evidence": [ { "id": "F1N0K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ] }, { "name": "TNFSF14", "type": "synonym", "evidence": [ { "id": "XP_005208908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208908" } ] }, { "name": "TNLG1D", "type": "synonym", "evidence": [ { "id": "XP_005208908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208908" } ] } ], "protein_names": [ { "name": "TNF superfamily member 14", "type": "synonym", "evidence": [ { "id": "F1N0K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0K4/entry#names_and_taxonomy" } ] }, { "name": "tumor necrosis factor ligand superfamily member 14 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005208908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208908" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFSF14", "url": "https://www.uniprot.org/uniprotkb/F1N0K4", "locus": { "chromosome": "7", "start_pos": 17843850, "end_pos": 17839014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012223", "url": "https://www.ensembl.org/id/ENSBTAG00000012223" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012223", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012223", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00184", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00184", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505521", "url": "https://www.ncbi.nlm.nih.gov/gene/505521", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HYYLYSK", "url": "https://omabrowser.org/oma/group/HYYLYSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0K4", "url": "https://www.orthodb.org/?gene=F1N0K4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11471", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11471", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11471:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11471:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5668541", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5676594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005208908", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SX11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0K4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0K4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEETVARPSVFVVDGQTDIPFRRLGHSRRRQPCSAAQLGLGLMLLLLVAGLAVQGWFLLQLHWRLEEIGAPLQDKSEKHWEELLQEQKPKQDKPAAHLTGADFSLTSREGPLRWETKLGLAFLRGLSYRDGALVVAQAGYYYIYSKVQLGGTGCSQGLTGCLPITHGLYKRTASYPEEVELLVNRRSRCGRADGSQVWWDSSFLGGVVHLDVGDEVVVRMPGERVIQVHDGTRSYFGAFMV", "length": 241, "header": "tr|F1N0K4-1|F1N0K4_BOVIN Isoform 1 of TNF superfamily member 14 OS=Bos taurus OX=9913 GN=TNFSF14 PE=3 SV=2 CANONICAL=F1N0K4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SX11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX11/entry", "sequence": { "sequence": "MEETVARPSVFVVDGQTDIPFRRLGHSRRRQPCSAAQLGLGLMLLLLVAGLAVQGWFLLQLHWRLEEIGAPLQKPKQDKPAAHLTGADFSLTSREGPLRWETKLGLAFLRGLSYRDGALVVAQAGYYYIYSKVQLGGTGCSQGLTGCLPITHGLYKRTASYPEEVELLVNRRSRCGRADGSQVWWDSSFLGGVVHLDVGDEVVVRMPGERVIQVHDGTRSYFGAFMV", "length": 227, "header": "tr|A0AAA9SX11-1|F1N0K4_BOVIN Computationally mapped isoform of TNF superfamily member 14 OS=Bos taurus OX=9913 GN=TNFSF14 PE=3 SV=2 CANONICAL=F1N0K4-1" }, "locus": { "chromosome": "7", "start_pos": 17842846, "end_pos": 17839168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092045.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092045.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087792.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087792.2" } ] } }, { "isoform_ac": "F1N0K4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0K4/entry", "sequence": { "sequence": "MEETVARPSVFVVDGQTDIPFRRLGHSRRRQPCSAAQLGLGLMLLLLVAGLAVQGWFLLQLHWRLEEIGAPLQDKSEKHWEELLQEQKPKQDKPAAHLTGADFSLTSREGPLRWETKLGLAFLRGLSYRDGALVVAQAGYYYIYSKVQLGGTGCSQGLTGCLPITHGLYKRTASYPEEVELLVNRRSRCGRADGSQVWWDSSFLGGVVHLDVGDEVVVRMPGERVIQVHDGTRSYFGAFMV", "length": 241, "header": "tr|F1N0K4-1|F1N0K4_BOVIN Isoform 1 of TNF superfamily member 14 OS=Bos taurus OX=9913 GN=TNFSF14 PE=3 SV=2 CANONICAL=F1N0K4-1" }, "locus": { "chromosome": "7", "start_pos": 17842846, "end_pos": 17839168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045141.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045141.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042556.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042556.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5668541", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "resource": "Reactome", "description": "TNFR2 non-canonical NF-kB pathway" }, { "id": "R-BTA-5669034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "resource": "Reactome", "description": "TNFs bind their physiological receptors" }, { "id": "R-BTA-5676594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676594", "resource": "Reactome", "description": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1V6R8-1", "protein_name": "TNF superfamily member 14", "gene_name": "TNFSF14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEETVVRPSVFVVDGQTDIPFTRLGRSRQRQPCSAARLGLGFLLLLLAAGLAIQGWFLLQLHWRLEAMAHPLQDRGAGSWEQLMQGANSSLTGRGGPLLWETKLGLAFLRGLTYRDGALVIAQAGYYYIYSKVQLGGVGCPQGLTGGLPITHGLYKRTSRYPEELELLLSRRSPCGRANNPRVWWDSSFLGGVVHLDAGEEVVVRVPGERLVQLRDDTRSYFGAFMV", "length": 227 }, "evidence": [ { "id": "F1N0K4", "url": "https://omabrowser.org/oma/group/F1N0K4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HCL5-1", "protein_name": "Tumor necrosis factor ligand superfamily member 14", "gene_name": "Tnfsf14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MESVVQPSVFVVDGQTDIPFRRLGQNRRRQRCGIAQVNLALMLLLGAGLATQGWFLLKLHQRVGDIARLPDTDTDSWEKLTQERRSHKANPAAHLTGANASLIGKGGPLLWETQLGLAFLRGLEYHNGALVTTEAGYYYVYSKVQLSGVGCPQGLANGLPITHGLYKRTSRYPKELELLVSRRSPCGRANSSRVWWDSSFLGGVVHLEAGEEVVVRVPGDRLVRPRDGTRSYFGAFMI", "length": 238 }, "evidence": [ { "id": "F1N0K4", "url": "https://omabrowser.org/oma/group/F1N0K4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "positive regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "id": "GO:0043027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043027", "evidence": [ { "database": "UniProtKB", "id": "F1N0K4", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0K4" }, { "id": "PS50049", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50049" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THD", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 241, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N082-1", "uniprot_ac": "F1N082", "uniprot_id": "F1N082_BOVIN", "mass": { "chemical_mass": 45410.0, "monoisotopic_mass": 45410.0 }, "refseq": { "ac": "NP_001243598", "name": "cytohesin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243598" }, "gene_names": [ { "name": "CYTH4", "type": "recommended", "evidence": [ { "id": "F1N082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ] }, { "name": "CYTH4", "type": "synonym", "evidence": [ { "id": "NP_001243598", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243598" } ] }, { "name": "PSCD4", "type": "synonym", "evidence": [ { "id": "NP_001243598", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243598" } ] } ], "protein_names": [ { "name": "Cytohesin 4", "type": "synonym", "evidence": [ { "id": "F1N082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N082/entry#names_and_taxonomy" } ] }, { "name": "cytohesin-4", "type": "synonym", "evidence": [ { "id": "NP_001243598", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243598" } ] }, { "name": "pleckstrin homology, Sec7 and coiled-coil domains 4", "type": "synonym", "evidence": [ { "id": "NP_001243598", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243598" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYTH4", "url": "https://www.uniprot.org/uniprotkb/F1N082", "locus": { "chromosome": "5", "start_pos": 75741096, "end_pos": 75703741, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014237", "url": "https://www.ensembl.org/id/ENSBTAG00000014237" } ] } } ], "crossref": [ { "id": "F1N082", "url": "https://alphafold.ebi.ac.uk/entry/F1N082", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014237", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00171", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01252", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01252", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517887", "url": "https://www.ncbi.nlm.nih.gov/gene/517887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517887", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517887", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LYNPNCK", "url": "https://omabrowser.org/oma/group/LYNPNCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ML63", "url": "https://www.orthodb.org/?gene=F1ML63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N082", "url": "https://www.orthodb.org/?gene=F1N082", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663:SF323", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663:SF323", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01369", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01369", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001243598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243598", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML63", "url": "https://www.uniprot.org/uniprotkb/F1ML63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML63-1", "url": "https://www.uniprot.org/uniprotkb/F1ML63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N082-1", "url": "https://www.uniprot.org/uniprotkb/F1N082-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLCHPDPGELSSGEAEELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFETAEESRMAQREKELCIGRKKFNMDPMKGIQYLIEHKLLTPDAQDIAQFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMETFASRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINGGSDLPEEQLRNLFDSIKSEPFSIPEDDGNDLTHTFFKPDREGWLLKLGGRVKTWKRRWFILTDSCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELCNPSCRGQKIKACKTDGDGKVVEGKHESYRISASSAEERDQWIEAIRASITRVPFYDLVSARKKKIASKQ", "length": 394, "header": "tr|F1N082-1|F1N082_BOVIN Isoform 1 of Cytohesin 4 OS=Bos taurus OX=9913 GN=CYTH4 PE=4 SV=2 CANONICAL=F1N082-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZC1/entry", "sequence": { "sequence": "MDLCHPDPGELSSGEAEELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFETAEESRMAQREKELCIGRKKFNMDPMKGIQYLIEHKLLTPDAQDIAQFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMETFASRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINGGSDLPEEQLRVAA", "length": 235, "header": "tr|A0AAA9SZC1-1|F1N082_BOVIN Computationally mapped isoform of Cytohesin 4 OS=Bos taurus OX=9913 GN=CYTH4 PE=4 SV=1 CANONICAL=F1N082-1" }, "locus": { "chromosome": "5", "start_pos": 75730125, "end_pos": 75703789, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109933.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109933.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088715.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088715.1" } ] } }, { "isoform_ac": "F1ML63-1", "url": "https://www.uniprot.org/uniprotkb/F1ML63/entry", "sequence": { "sequence": "MDLCHPDPGELSSGEAEELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFETAEESRMAQREKELCIGRKKFNMDPMKGIQYLIEHKLLTPDAQDIAQFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMETFASRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINGGSDLPEEQLRNLFDSIKSEPFSIPEDDGNDLTHTFFKPDREGWLLKLGGRVKTWKRRWFILTDSCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELCNPSCRGQKIKACKTDGDGKVVEGKHESYRISASSAEERDQWIEAIR", "length": 371, "header": "tr|F1ML63-1|F1N082_BOVIN Computationally mapped isoform of Cytohesin 4 OS=Bos taurus OX=9913 GN=CYTH4 PE=4 SV=2 CANONICAL=F1N082-1" }, "locus": { "chromosome": "5", "start_pos": 75740835, "end_pos": 75703789, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018923.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018923.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018923.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018923.3" } ] } }, { "isoform_ac": "F1N082-1", "url": "https://www.uniprot.org/uniprotkb/F1N082/entry", "sequence": { "sequence": "MDLCHPDPGELSSGEAEELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFETAEESRMAQREKELCIGRKKFNMDPMKGIQYLIEHKLLTPDAQDIAQFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMETFASRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINGGSDLPEEQLRNLFDSIKSEPFSIPEDDGNDLTHTFFKPDREGWLLKLGGRVKTWKRRWFILTDSCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELCNPSCRGQKIKACKTDGDGKVVEGKHESYRISASSAEERDQWIEAIRASITRVPFYDLVSARKKKIASKQ", "length": 394, "header": "tr|F1N082-1|F1N082_BOVIN Isoform 1 of Cytohesin 4 OS=Bos taurus OX=9913 GN=CYTH4 PE=4 SV=2 CANONICAL=F1N082-1" }, "locus": { "chromosome": "5", "start_pos": 75732709, "end_pos": 75703789, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030432.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030432.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030414.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030414.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517887", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517887", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0A0-1", "protein_name": "Cytohesin 4", "gene_name": "Cyth4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYVMQGSLQQPWGTEPNNPPLSPDTAELSSGEARELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFESTEESRMAQKEKEMCIGRKKFNMDPAKGIQYLTEHKLLTSDVQDIAQFLYKGEGLNKTAIGTYLGEKDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNPGVFRSTDTCYVLSFSVIMLNTGLHNPNVRDRPHFEHFVSMNRGINSGSDLPEEQLRNLFDSIKSEPFSIPEDDGSDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGKVVEGKHESYRISAANAEERDQWIEAIRASITRVPFYDLLSARKKKIVGKQ", "length": 411 }, "evidence": [ { "id": "F1N082", "url": "https://omabrowser.org/oma/group/F1N082/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SKL5-1", "protein_name": "Cytohesin 4", "gene_name": "CYTH4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDLCHPDPGELSSGETEELQRIKWHRKQLLEDIQKLKEEIADVFAQIDCFETAEESRVAQKEKELSIGRKKFNMDPVKGIQYLIEHKLLSPDVQDIAQFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMETFAARYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINDGSDLPEEQLRNLFDSIKNEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDSCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGKVVEGKHESYRISAASAEERDQWIQAIRASITRVPFYDLVSARKKKIASKQ", "length": 394 }, "evidence": [ { "id": "F1N082", "url": "https://omabrowser.org/oma/group/F1N082/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80YW0-1", "protein_name": "Cytohesin-4", "gene_name": "Cyth4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDVCHTDPAELSSGEAKELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFESTEESRMAQKEKEMCIGRKKFNMDPNKGIQYLIEHKLLTSDVQDIAQFLYKGDGLNKTAIGTYLGEKDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNPGVFRSTDTCYVLSFSVIMLNTGLHNPNVRDRPPFERFVTMNRGINSGSDLPEEQLRNLFDSIKSEPFSIPEDDGGDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVEDPKKPFCLELYNPSCRGQKIKACKTDGDGKVVEGKHESYRISAANAEERDQWIEAIRASITRVPFYDLLSARKKKIVGK", "length": 393 }, "evidence": [ { "id": "F1N082", "url": "https://omabrowser.org/oma/group/F1N082/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UIA0-1", "protein_name": "Cytohesin-4", "gene_name": "CYTH4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ", "length": 394 }, "evidence": [ { "id": "F1N082", "url": "https://omabrowser.org/oma/group/F1N082/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of ARF protein signal transduction", "id": "GO:0032012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "database": "UniProtKB", "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N082", "url": "https://www.uniprot.org/uniprotkb/F1N082" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N082-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 394, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N082-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N082" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N082" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 259, "end_pos": 375, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N082" }, { "id": "PS50190", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50190" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEC7", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 241, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 307, "end_pos": 309 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1A2-1", "uniprot_ac": "F1N1A2", "uniprot_id": "F1N1A2_BOVIN", "mass": { "chemical_mass": 157936.0, "monoisotopic_mass": 157936.0 }, "refseq": {}, "gene_names": [ { "name": "DHX57", "type": "recommended", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ], "protein_names": [ { "name": "Putative ATP-dependent RNA helicase DHX57", "type": "recommended", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2/entry#names_and_taxonomy" } ] }, { "name": "DEAH box protein 57", "type": "synonym", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable ATP-binding RNA helicase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M0#function" }, { "database": "UniProtKB", "id": "ARBA00057709", "url": "https://www.uniprot.org/uniprotkb/ARBA00057709#function" }, { "database": "UniProtKB", "id": "A0AAA9TJM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJM0#function" }, { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHX57", "url": "https://www.uniprot.org/uniprotkb/F1N1A2", "locus": { "chromosome": "11", "start_pos": 21145287, "end_pos": 21205582, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014679", "url": "https://www.ensembl.org/id/ENSBTAG00000014679" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014679", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014679", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14317", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14317", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17985", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17985", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18791", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23825", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23825", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540993", "url": "https://www.ncbi.nlm.nih.gov/gene/540993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059510", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059510", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1A2", "url": "https://www.orthodb.org/?gene=F1N1A2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934:SF145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934:SF145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00642", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00642", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04408", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27513", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27513", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T2M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1A2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1A2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEERYQVWVSARSWIYGVKMSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGSSGGGVGGNRKASSRIWDDGDDFCIFSESRHSSRPSNSSVRKGDGRPKWKPEAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGVSGEEEDDEPDYDDEQYWSPGREASLVPDSDPLECAGSGLVEPHNPEFTVSAFAVHRLSRYGFHTEHCQAALRICDGDMGASLERLLTQCFSETFGERMKISEAVAHMSLEECVEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSKFCKFKQKESTKNIQEASLEVCKFYLKGNCKFGSKCKFKHEVPPNQIVGRVERNVDDSHLNANEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYGKALTFAETSEPVVYSLITLLEEESEITKLLTNTHHKYSVPPVNFLPVSPGTRLNNPVCRKPVIPSNSFFSNQIPEVEKESEPEEETDEDEGPAPVMVENESYVNLKKKISKRYDWQAKSVHAENVKICKQFRIKQASRQFQSVLQERQSLPAWEERENILKLLSKHQVLVVSGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVTHIIVDEVHERTEESDFLLLVLKDIVLQRPTLQVILMSATLNAELFSEYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYARSMKQMSKEKLKARRSRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYQGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHFNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFARLIEPPHADSLRASKIRLRDLGALTPDETLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLRAYKGWQLSMKEGMRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFVKEGLRAREIEKRAQGGGDGILDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSDELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLVYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQKGEFVVSLDDGWIRFAAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISMIVKLVTTQ", "length": 1403, "header": "tr|F1N1A2-1|F1N1A2_BOVIN Isoform 1 of Putative ATP-dependent RNA helicase DHX57 OS=Bos taurus OX=9913 GN=DHX57 PE=3 SV=3 CANONICAL=F1N1A2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M0/entry", "sequence": { "sequence": "MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGSSGGGVGGNRKASSRIWDDGDDFCIFSESRHSSRPSNSSVRKGDGRPKWKPEAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGVSGEEEDDEPDYDDEQYWSPGREASLVPDSDPLECAGSGLVEPHNPEFTVSAFAVHRLSRYGFHTEHCQAALRICDGDMGASLERLLTQCFSETFGERMKISEAVAHMSLEECVEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSKFCKFKQKESTKNIQEASLEVCKFYLKGNCKFGSKCKFKHEVPPNQIVGRVERNVDDSHLNANEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYGKALTFAETSEPVVYSLITLLEEESEITKLLTNTHHKYSVPPVNFLPVSPGTRLNNPVCRKPVIPSNSFFSNQIPEVEKESEPEEETDEDEGPAPVMVENESYVNLKKKISKRYDWQAKSVHAENVKICKQFRIKQASRQFQSVLQERQSLPAWEERENILKLLSKHQVLVVSGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVTHIIVDEVHERTEESDFLLLVLKDIVLQRPTLQVILMSATLNAELFSEYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYARSMKQMSKEKLKARRSRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYQGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHFNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFARLIEPPHADSLRASKIRLRDLGALTPDETLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLRAYKGWQLSMKEGMRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFVKEGLRAREIEKRAQGGGDGILDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSDELKFVTKNDGYVHIHPSSVNYQHSASPA", "length": 1275, "header": "tr|A0AAA9T2M0-1|F1N1A2_BOVIN Computationally mapped isoform of Putative ATP-dependent RNA helicase DHX57 OS=Bos taurus OX=9913 GN=DHX57 PE=3 SV=1 CANONICAL=F1N1A2-1" }, "locus": { "chromosome": "11", "start_pos": 21198813, "end_pos": 21149270, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109623.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109623.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090884.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090884.1" } ] } }, { "isoform_ac": "A0AAA9TJM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJM0/entry", "sequence": { "sequence": "MLEERYQVWVSARSWIYGVKMSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGSSGGGVGGNRKASSRIWDDGDDFCIFSESRHSSRPSNSSVRKGDGRPKWKPEAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGVSGEEEDDEPDYDDEQYWSPGREASLVPDSDPLECAGSGLVEPHNPEFTVSAFAVHRLSRYGFHTEHCQAALRICDGDMGASLERLLTQCFSETFGERMKISEAVAHMSLEECVEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSKFCKFKQKESTKNIQEASLEVCKFYLKGNCKFGSKCKFKHEVPPNQIVGRVERNVDDSHLNANEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYGKALTFAETSEPVVYSLITLLEEESEITKLLTNTHHKYSVPPVNFLPVSPGTRLNNPVCRKPVIPSNSFFSNQIPEVEKESEPEEETDEDEGPAPVMVENESYVNLKKKISKRYDWQAKSVHAENVKICKQFRIKQASRQFQSVLQERQSLPAWEERENILKLLSKHQVLVVSGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVTHIIVDEVHERTEESDFLLLVLKDIVLQRPTLQVILMSATLNAELFSEYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYARSMKQMSKEKLKARRSRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYQGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHFNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFARLIEPPHADSLRASKIRLRDLGALTPDETLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLRAYKGWQLSMKEGMRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFVKEGLRAREIEKRAQGGGDGILDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSDELKFVTKNDGYVHIHPSSVNYQVRMAG", "length": 1294, "header": "tr|A0AAA9TJM0-1|F1N1A2_BOVIN Computationally mapped isoform of Putative ATP-dependent RNA helicase DHX57 OS=Bos taurus OX=9913 GN=DHX57 PE=3 SV=1 CANONICAL=F1N1A2-1" }, "locus": { "chromosome": "11", "start_pos": 21205126, "end_pos": 21152022, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095060.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095060.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098545.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098545.1" } ] } }, { "isoform_ac": "F1N1A2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1A2/entry", "sequence": { "sequence": "MLEERYQVWVSARSWIYGVKMSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGSSGGGVGGNRKASSRIWDDGDDFCIFSESRHSSRPSNSSVRKGDGRPKWKPEAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGVSGEEEDDEPDYDDEQYWSPGREASLVPDSDPLECAGSGLVEPHNPEFTVSAFAVHRLSRYGFHTEHCQAALRICDGDMGASLERLLTQCFSETFGERMKISEAVAHMSLEECVEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSKFCKFKQKESTKNIQEASLEVCKFYLKGNCKFGSKCKFKHEVPPNQIVGRVERNVDDSHLNANEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYGKALTFAETSEPVVYSLITLLEEESEITKLLTNTHHKYSVPPVNFLPVSPGTRLNNPVCRKPVIPSNSFFSNQIPEVEKESEPEEETDEDEGPAPVMVENESYVNLKKKISKRYDWQAKSVHAENVKICKQFRIKQASRQFQSVLQERQSLPAWEERENILKLLSKHQVLVVSGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVTHIIVDEVHERTEESDFLLLVLKDIVLQRPTLQVILMSATLNAELFSEYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYARSMKQMSKEKLKARRSRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYQGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHFNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFARLIEPPHADSLRASKIRLRDLGALTPDETLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLRAYKGWQLSMKEGMRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFVKEGLRAREIEKRAQGGGDGILDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSDELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLVYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQKGEFVVSLDDGWIRFAAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISMIVKLVTTQ", "length": 1403, "header": "tr|F1N1A2-1|F1N1A2_BOVIN Isoform 1 of Putative ATP-dependent RNA helicase DHX57 OS=Bos taurus OX=9913 GN=DHX57 PE=3 SV=3 CANONICAL=F1N1A2-1" }, "locus": { "chromosome": "11", "start_pos": 21205126, "end_pos": 21145839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019540.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019540.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019540.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019540.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "F1N1A2", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" }, { "id": "PS50103", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50103" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C3H1-type", "eco_id": "ECO_0000259", "start_pos": 314, "end_pos": 341, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 570, "end_pos": 737, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 846, "end_pos": 1026, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" }, { "id": "PS50030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 235, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.4.13", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13" }, { "id": "3.6.4.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.13" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 509, "end_pos": 511 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N197-1", "uniprot_ac": "F1N197", "uniprot_id": "F1N197_BOVIN", "mass": { "chemical_mass": 37054.0, "monoisotopic_mass": 37054.0 }, "refseq": {}, "gene_names": [ { "name": "AKT1S1", "type": "recommended", "evidence": [ { "id": "F1N197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ] } ], "protein_names": [ { "name": "AKT1 substrate 1", "type": "synonym", "evidence": [ { "id": "F1N197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N197/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKT1S1", "url": "https://www.uniprot.org/uniprotkb/F1N197", "locus": { "chromosome": "18", "start_pos": 56216994, "end_pos": 56224867, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005763", "url": "https://www.ensembl.org/id/ENSBTAG00000005763" } ] } } ], "crossref": [ { "id": "F1N197", "url": "https://alphafold.ebi.ac.uk/entry/F1N197", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005763", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005763", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N197", "url": "https://www.orthodb.org/?gene=F1N197", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21844", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21844", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21844:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21844:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22911", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22911", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-165159", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-165159", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166208", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3371571", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371571", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TU40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N197-1", "url": "https://www.uniprot.org/uniprotkb/F1N197-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAAAAARPPVPPPAPQPPSPARSPPRPALAREEDEEDEDEPTETETSGERLGVSDNGGLFVMDEDTTLQDLPPFCESDPESTDDGSLSEETPAGPPAYSVPPASALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPVRALFAGPGPYRGEHARTGAAGGRGHSGLRGPAAATAQHQRLPEAEAEILRPKELPGPASVPPLHYTPAPPPGPANPSQIRDRPPTPGPPGLTSSCRFPPPFQPTITPAPPNGAYPVSGLGLSALCPATDFFLVRNWLAPRPGRG", "length": 354, "header": "tr|F1N197-1|F1N197_BOVIN Isoform 1 of AKT1 substrate 1 OS=Bos taurus OX=9913 GN=AKT1S1 PE=4 SV=2 CANONICAL=F1N197-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TU40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU40/entry", "sequence": { "sequence": "MDTAVANAPLGSGETPVPPCWSPESGVREAGCATWRRGKDAEVTARMASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAAAAARPPVPPPAPQPPSPARSPPRPALAREEDEEDEDEPTETETSGERLGVSDNGGLFVMDEDTTLQDLPPFCESDPESTDDGSLSEETPAGPPAYSVPPASALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY", "length": 302, "header": "tr|A0AAA9TU40-1|F1N197_BOVIN Computationally mapped isoform of AKT1 substrate 1 OS=Bos taurus OX=9913 GN=AKT1S1 PE=4 SV=1 CANONICAL=F1N197-1" }, "locus": { "chromosome": "18", "start_pos": 56224668, "end_pos": 56217859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106664.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106664.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100905.1" } ] } }, { "isoform_ac": "F1N197-1", "url": "https://www.uniprot.org/uniprotkb/F1N197/entry", "sequence": { "sequence": "MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAAAAARPPVPPPAPQPPSPARSPPRPALAREEDEEDEDEPTETETSGERLGVSDNGGLFVMDEDTTLQDLPPFCESDPESTDDGSLSEETPAGPPAYSVPPASALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPVRALFAGPGPYRGEHARTGAAGGRGHSGLRGPAAATAQHQRLPEAEAEILRPKELPGPASVPPLHYTPAPPPGPANPSQIRDRPPTPGPPGLTSSCRFPPPFQPTITPAPPNGAYPVSGLGLSALCPATDFFLVRNWLAPRPGRG", "length": 354, "header": "tr|F1N197-1|F1N197_BOVIN Isoform 1 of AKT1 substrate 1 OS=Bos taurus OX=9913 GN=AKT1S1 PE=4 SV=2 CANONICAL=F1N197-1" }, "locus": { "chromosome": "18", "start_pos": 56221066, "end_pos": 56217572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007575.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007575.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007575.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007575.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 295, "start_aa": "Thr", "end_pos": 295, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr295", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-165159", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-165159", "resource": "Reactome", "description": "MTOR signalling" }, { "id": "R-BTA-166208", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166208", "resource": "Reactome", "description": "mTORC1-mediated signalling" }, { "id": "R-BTA-3371571", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371571", "resource": "Reactome", "description": "HSF1-dependent transactivation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" }, { "name": "neurotrophin TRK receptor signaling pathway", "id": "GO:0048011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048011", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" }, { "name": "regulation of neuron apoptotic process", "id": "GO:0043523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043523", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" }, { "name": "negative regulation of cell size", "id": "GO:0045792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045792", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" }, { "name": "TORC1 complex", "id": "GO:0031931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031931", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "F1N197", "url": "https://www.uniprot.org/uniprotkb/F1N197" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N197-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N197-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N197" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N197" }, { "id": "PF22911", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22911" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Proline-rich AKT1 substrate 1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 72, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 295 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MZX9-1", "uniprot_ac": "F1MZX9", "uniprot_id": "F1MZX9_BOVIN", "mass": { "chemical_mass": 35016.0, "monoisotopic_mass": 35016.0 }, "refseq": {}, "gene_names": [ { "name": "SULT6B1", "type": "recommended", "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ] } ], "protein_names": [ { "name": "Sulfotransferase", "type": "recommended", "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine.", "evidence": [ { "database": "UniProtKB", "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9#function" }, { "database": "UniProtKB", "id": "ARBA00059518", "url": "https://www.uniprot.org/uniprotkb/ARBA00059518#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SULT6B1", "url": "https://www.uniprot.org/uniprotkb/F1MZX9", "locus": { "chromosome": "11", "start_pos": 19605859, "end_pos": 19621401, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008707", "url": "https://www.ensembl.org/id/ENSBTAG00000008707" } ] } } ], "crossref": [ { "id": "F1MZX9", "url": "https://alphafold.ebi.ac.uk/entry/F1MZX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008707", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008707", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFPILEC", "url": "https://omabrowser.org/oma/group/EFPILEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MZX9", "url": "https://www.orthodb.org/?gene=F1MZX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11783", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11783", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156584", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "26422", "url": "https://www.rhea-db.org/rhea/26422", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70607", "url": "https://www.rhea-db.org/rhea/70607", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZX9-1", "url": "https://www.uniprot.org/uniprotkb/F1MZX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTANSKFIDYIDEALEKSKETVLSHLFFTYQGIPYPVTMCTSETFKALDAFEARSDDIVLASYPKCGSNWILHIISELMFADSKQKYDYPEFPVLECGDPEKYQRMKQFPSPRILATHLHYDKLPGSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYGSWDDFFRQFMKGQVSWGSYFDFAINWNKHLDDENVMFILYEDLRENLATGIKRIAEFFGFSPSGEQIQTISARSTFHAMRAKSQETHGAVGPFLFRKGEVGDWKNLFSETQNQEMDEKFKECLAGTALGTKLKYNSYCQP", "length": 303, "header": "tr|F1MZX9-1|F1MZX9_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=SULT6B1 PE=3 SV=3 CANONICAL=F1MZX9-1" }, "isoforms": [ { "isoform_ac": "F1MZX9-1", "url": "https://www.uniprot.org/uniprotkb/F1MZX9/entry", "sequence": { "sequence": "MTANSKFIDYIDEALEKSKETVLSHLFFTYQGIPYPVTMCTSETFKALDAFEARSDDIVLASYPKCGSNWILHIISELMFADSKQKYDYPEFPVLECGDPEKYQRMKQFPSPRILATHLHYDKLPGSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYGSWDDFFRQFMKGQVSWGSYFDFAINWNKHLDDENVMFILYEDLRENLATGIKRIAEFFGFSPSGEQIQTISARSTFHAMRAKSQETHGAVGPFLFRKGEVGDWKNLFSETQNQEMDEKFKECLAGTALGTKLKYNSYCQP", "length": 303, "header": "tr|F1MZX9-1|F1MZX9_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=SULT6B1 PE=3 SV=3 CANONICAL=F1MZX9-1" }, "locus": { "chromosome": "11", "start_pos": 19621401, "end_pos": 19605862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011474.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011474.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011474.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011474.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-156584", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156584", "resource": "Reactome", "description": "Cytosolic sulfonation of small molecules" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BHE6-1", "protein_name": "Sulfotransferase", "gene_name": "SULT6B1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATNSKFIDYIDEALEKSKETALSHLLFTYQGIPYPVTMCTSKTFQALDTFEARSDDIVLASYPKCGSNWILHIISELIFADSKKKFEYPEFPVLECGDPEKYKRMSQFPSPRILTTHLHYDKLPGSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYGSWDEFFRQFMKGQVSWGSYFDFAINWNKHLNDENVKLILYEDLKEDLAAGIKQIAEFFGFFPSGEQIQTISAQSTFQAMRAQSQETHGAVGPFLFRKGEVGDWRKLFSETQNQEMDEKFKECLAGTALGTKLKYDLYCQA", "length": 303 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QDN5-1", "protein_name": "Sulfotransferase", "gene_name": "Sult6b1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADKSKFIEYIHDALEKSKETALSHLFFTYQGIPYPVTMCTSETFQALDAFEARSDDIVIASYPKCGSNWILHIVSELIFAVSKKKYTCPEFPVLECGDTEKYQRMKLFPSPRILTTHLHYDKLPQSVFKNKAKILVIFRNPKDTAASFFHFHNDVPDIPSYASWDEFFRQFIQGQVSWGSYFDFAINWNKHIDDENVKFMLYEDLKENLLAGIKQISEFLGFSLTDEQIRAVSDQSTFQAMRENSQETHGAIGPFLFRKGEVGDWKNLFNETQNQEMDERFKECLAGTSLGVKLKYESHCLA", "length": 303 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XZJ5-1", "protein_name": "Sulfotransferase", "gene_name": "SULT6B1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQQKLVSMAEENKAFADEMNKALAKSEGFTLKDLLFSYRGTPYPVTVCSAETFQALENLEARRDDMVLVSYPKCGVNWLIQILNDLIFTTIQSKPVSAELPFIECGDPDKYQRMKQIPSPRILATHLNYDFLPKSIFKSKAKILVLFRNPKDTAVSFFHFHKNVPSVPSYNSWDEFFSEFMNGKVGWGSYFDHAVTWNKHIEDENTMIVIYEDLKENLTSGVKQIAEFFGFSPTAEQIQSIADRATFQAVKNKAQETHGAVGTVLFRKGVVGDWKNLFTEAQNQEMDAKFKACLEGTKLGAKLKYDVYCKA", "length": 312 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "M0R952-1", "protein_name": "Sulfotransferase", "gene_name": "Sult6b1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEKSKFIEYIDDALEKSKETALSQLFLTHQGIPYPVTMCTLETFRALDAFEARSDDILLASYPKCGSNWILHIVSELIFAVSKKKYACPEFPVLECGDAEKYQRMKRLPSPRILTTHLHCDKLPQSVFKSKAKILVMFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINWNKHIDEENVKFILYEDLKENLVVGIKQISEFLGFSLTDAQIKTISAQSTFQAMRAKSQETHGAIGPFLFRKGEVGDWKSLFNETQNQEMDERFKESLAGISLGDKLKYDSYCLA", "length": 303 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0CC03-1", "protein_name": "Sulfotransferase 6B1", "gene_name": "Sult6b1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADKSKFIDYIDDALEKSKETTLSQLFLTYQGIPYPVTMCTQETFRALDAFEARSDDVLLASYPKCGSNWILHIVSELIFAVSKKKYACPEFPVLECGDAEKYQRMKLFPSPRILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINWNKHIDDENVKFILYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAIGPFLFRKGEVGDWKRLFNETQNQEMDERFKECLAGTSLGDKLKYEAYCLA", "length": 303 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6IMI4-1", "protein_name": "Sulfotransferase 6B1", "gene_name": "SULT6B1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADKSKFIEYIDEALEKSKETALSHLFFTYQGIPYPITMCTSETFQALDTFEARHDDIVLASYPKCGSNWILHIVSELIYAVSKKKYKYPEFPVLECGDSEKYQRMKGFPSPRILATHLHYDKLPGSIFENKAKILVIFRNPKDTAVSFLHFHNDVPDIPSYGSWDEFFRQFMKGQVSWGRYFDFAINWNKHLDGDNVKFILYEDLKENLAAGIKQIAEFLGFFLTGEQIQTISVQSTFQAMRAKSQDTHGAVGPFLFRKGEVGDWKNLFSEIQNQEMDEKFKECLAGTSLGAKLKYESYCQG", "length": 303 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8L5A7-1", "protein_name": "Cytosolic sulfotransferase 15", "gene_name": "SOT15", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATSSMKSIPMAIPSFSMCHKLELLKEGKTRDVPKAEEDEGLSCEFQEMLDSLPKERGWRTRYLYLFQGFWCQAKEIQAIMSFQKHFQSLENDVVLATIPKSGTTWLKALTFTILNRHRFDPVASSTNHPLFTSNPHDLVPFFEYKLYANGDVPDLSGLASPRTFATHLPFGSLKETIEKPGVKVVYLCRNPFDTFISSWHYTNNIKSESVSPVLLDQAFDLYCRGVIGFGPFWEHMLGYWRESLKRPEKVFFLRYEDLKDDIETNLKRLATFLELPFTEEEERKGVVKAIAELCSFENLKKLEVNKSNKSIKNFENRFLFRKGEVSDWVNYLSPSQVERLSALVDDKLGGSGLTFRLS", "length": 359 }, "evidence": [ { "id": "F1MZX9", "url": "https://omabrowser.org/oma/group/F1MZX9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sulfation", "id": "GO:0051923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051923", "evidence": [ { "database": "UniProtKB", "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MZX9", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "26422", "name": "", "equation": "thyroxine + 3'-phosphoadenylyl sulfate = thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MZX9-1" ], "evidence": [ { "id": "26422", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26422" } ] }, { "id": "70607", "name": "", "equation": "4-ethylphenol + 3'-phosphoadenylyl sulfate = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T0Y3-1", "P50227-1", "P19217-1", "A0AAA9RW31-1", "A0A3Q1N4J6-1", "F1MZX9-1", "E1BG19-1", "E1BAC7-1", "E1BIS9-1", "A0ABI0NTS0-1", "A0AAA9SGU9-1", "A0ABI0P531-1", "E1BJ78-1" ], "evidence": [ { "id": "70607", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70607" } ] }, { "id": "R-BTA-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-176486" ], "output_participant_list": [ "R-ALL-176519" ], "enzyme_list": [ "Q3T0Y3-1", "P50227-1", "F1MZX9-1", "E1BG19-1", "A0ABI0NTS0-1" ], "evidence": [ { "id": "R-BTA-176474", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176474" } ] }, { "id": "R-BTA-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-176667" ], "output_participant_list": [ "R-ALL-176564" ], "enzyme_list": [ "Q3T0Y3-1", "P50227-1", "F1MZX9-1", "E1BG19-1", "A0ABI0NTS0-1" ], "evidence": [ { "id": "R-BTA-176585", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176585" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-176486", "participant_name": "3,3'-diiodothyronine [cytosol]", "crossref": [ { "id": "35430", "database": "ChEBI", "url": "" }, { "id": "11533682", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000016051523", "database": "ZINC", "url": "" }, { "id": "ZINC000045331653", "database": "ZINC", "url": "" }, { "id": "HMDB0005869", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-176519", "participant_name": "3,3'-diiodothyronine 4-sulfate [cytosol]", "crossref": [ { "id": "35431", "database": "ChEBI", "url": "" }, { "id": "ZINC000031706818", "database": "ZINC", "url": "" }, { "id": "11533681", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-176564", "participant_name": "3,5,3'-triiodothyronine 4-sulfate [cytosol]", "crossref": [ { "id": "ZINC000085552312", "database": "ZINC", "url": "" }, { "id": "35432", "database": "ChEBI", "url": "" }, { "id": "HMDB0003036", "database": "HMDB Metabolite", "url": "" }, { "id": "11533680", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-176667", "participant_name": "T3 [cytosol]", "crossref": [ { "id": "533015", "database": "ChEBI", "url": "" }, { "id": "ZINC000003830999", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1N4J6", "gene_name": "", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1N4J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4J6" } ] } ] }, { "uniprot_ac": "A0AAA9RW31", "gene_name": "LOC100300896", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0AAA9RW31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW31" } ] } ] }, { "uniprot_ac": "A0AAA9SGU9", "gene_name": "LOC514658", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ] } ] }, { "uniprot_ac": "A0ABI0NTS0", "gene_name": "SULT1C2", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0ABI0NTS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTS0" } ] } ] }, { "uniprot_ac": "A0ABI0P531", "gene_name": "LOC112446736", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0ABI0P531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P531" } ] } ] }, { "uniprot_ac": "E1BAC7", "gene_name": "SULT1D1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BAC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAC7" } ] } ] }, { "uniprot_ac": "E1BG19", "gene_name": "SULT2A1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BG19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG19" } ] } ] }, { "uniprot_ac": "E1BIS9", "gene_name": "SULT1C3", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIS9" } ] } ] }, { "uniprot_ac": "E1BJ78", "gene_name": "LOC783020", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ] } ] }, { "uniprot_ac": "F1MZX9", "gene_name": "SULT6B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ] } ] }, { "uniprot_ac": "P19217", "gene_name": "SULT1E1", "activity": [ { "ec_number": "2.8.2.4", "activity": "estrone + 3'-phosphoadenylyl sulfate = estrone 3-sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "P19217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19217" } ] }, { "ec_number": "2.8.2.4", "activity": "", "evidence": [ { "id": "P19217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19217" } ] } ] }, { "uniprot_ac": "P50227", "gene_name": "SULT1A1", "activity": [ { "ec_number": "2.8.2.1", "activity": "a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "P50227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P50227" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P50227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P50227" } ] } ] }, { "uniprot_ac": "Q3T0Y3", "gene_name": "SULT1B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] }, { "ec_number": "2.8.2.1", "activity": "a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MZX9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MZX9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MZX9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" }, { "id": "PF00685", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfotransferase", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 289, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N000-1", "uniprot_ac": "F1N000", "uniprot_id": "F1N000_BOVIN", "mass": { "chemical_mass": 66671.0, "monoisotopic_mass": 66671.0 }, "refseq": {}, "gene_names": [ { "name": "SRRM4", "type": "recommended", "evidence": [ { "id": "F1N000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ] } ], "protein_names": [ { "name": "Serine/arginine repetitive matrix 4", "type": "synonym", "evidence": [ { "id": "F1N000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N000/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRRM4", "url": "https://www.uniprot.org/uniprotkb/F1N000", "locus": { "chromosome": "17", "start_pos": 56189374, "end_pos": 56355552, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008676", "url": "https://www.ensembl.org/id/ENSBTAG00000008676" } ] } } ], "crossref": [ { "id": "F1N000", "url": "https://alphafold.ebi.ac.uk/entry/F1N000", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008676", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008676", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N000", "url": "https://www.orthodb.org/?gene=F1N000", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34755", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34755", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34755:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34755:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N000-1", "url": "https://www.uniprot.org/uniprotkb/F1N000-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVQQGEKQLFEKFWRGTFKAVATPRPESIIVASITARKPLPRTEPQSSPMVPAQDGPSEKLSQHLASKVLGTNSWDRGKACREPSPTRARSASHSKDLTPLPSSRGKKKKKKATRKKRRRSPSYSPSPVKKKKKKSSKKHKRHRHLGSSSSSPKSRRKEEKRHKKQSRSRPRKSRRRRHHHCPSRSQSSESRSSSCDSRHRGRSPEGGRKSRRRHSRRCSKTLCKASPEARSSPQPSQPLQMLSFLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSMQISSTRSRGQEKGSPSGGLSKSRDPNSGNTSDSGNSFTTSSPQNKGATLENLSPTSRGRESRGFQSPCLECTEVKKSDLVPSTARSSPMRGCSRSSSYASTRSSSHSSRSPNLRASPRYTRSRSTSSGKRSSSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERNPKYIEKDSQQRERERARRRRRSYSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSSGLSSTSSWYSSSSSRSASRSYSRSRSRSRSRTLSSSSCSSRSPSLGSRSRSRSRSRSRSRSGSYSSADSYSSTRR", "length": 599, "header": "tr|F1N000-1|F1N000_BOVIN Isoform 1 of Serine/arginine repetitive matrix 4 OS=Bos taurus OX=9913 GN=SRRM4 PE=4 SV=3 CANONICAL=F1N000-1" }, "isoforms": [ { "isoform_ac": "F1N000-1", "url": "https://www.uniprot.org/uniprotkb/F1N000/entry", "sequence": { "sequence": "MASVQQGEKQLFEKFWRGTFKAVATPRPESIIVASITARKPLPRTEPQSSPMVPAQDGPSEKLSQHLASKVLGTNSWDRGKACREPSPTRARSASHSKDLTPLPSSRGKKKKKKATRKKRRRSPSYSPSPVKKKKKKSSKKHKRHRHLGSSSSSPKSRRKEEKRHKKQSRSRPRKSRRRRHHHCPSRSQSSESRSSSCDSRHRGRSPEGGRKSRRRHSRRCSKTLCKASPEARSSPQPSQPLQMLSFLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSMQISSTRSRGQEKGSPSGGLSKSRDPNSGNTSDSGNSFTTSSPQNKGATLENLSPTSRGRESRGFQSPCLECTEVKKSDLVPSTARSSPMRGCSRSSSYASTRSSSHSSRSPNLRASPRYTRSRSTSSGKRSSSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERNPKYIEKDSQQRERERARRRRRSYSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSSGLSSTSSWYSSSSSRSASRSYSRSRSRSRSRTLSSSSCSSRSPSLGSRSRSRSRSRSRSRSGSYSSADSYSSTRR", "length": 599, "header": "tr|F1N000-1|F1N000_BOVIN Isoform 1 of Serine/arginine repetitive matrix 4 OS=Bos taurus OX=9913 GN=SRRM4 PE=4 SV=3 CANONICAL=F1N000-1" }, "locus": { "chromosome": "17", "start_pos": 56355552, "end_pos": 56189391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011438.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011438.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011438.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011438.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" }, { "name": "neuron maturation", "id": "GO:0042551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042551", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "F1N000", "url": "https://www.uniprot.org/uniprotkb/F1N000" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N000-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 599, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N000-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N000" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N000" }, { "id": "PF15230", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15230" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serine/arginine repetitive matrix protein C-terminal", "eco_id": "ECO_0000259", "start_pos": 453, "end_pos": 518, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 285, "end_pos": 287 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 344, "end_pos": 346 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N011-1", "uniprot_ac": "F1N011", "uniprot_id": "F1N011_BOVIN", "mass": { "chemical_mass": 37278.0, "monoisotopic_mass": 37278.0 }, "refseq": { "ac": "XP_002690422", "name": "proto-oncogene Mas", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690422" }, "gene_names": [ { "name": "MAS1", "type": "recommended", "evidence": [ { "id": "F1N011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ] }, { "name": "MAS1", "type": "synonym", "evidence": [ { "id": "XP_002690422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690422" } ] } ], "protein_names": [ { "name": "MAS1 proto-onco, G protein-coupled receptor", "type": "synonym", "evidence": [ { "id": "F1N011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N011/entry#names_and_taxonomy" } ] }, { "name": "proto-oncogene Mas", "type": "synonym", "evidence": [ { "id": "XP_002690422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690422" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAS1", "url": "https://www.uniprot.org/uniprotkb/F1N011", "locus": { "chromosome": "9", "start_pos": 96123620, "end_pos": 96122643, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031724", "url": "https://www.ensembl.org/id/ENSBTAG00000031724" } ] } } ], "crossref": [ { "id": "ENSBTAG00000031724", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031724", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783010", "url": "https://www.ncbi.nlm.nih.gov/gene/783010", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783010", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783010", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DGNHCQA", "url": "https://omabrowser.org/oma/group/DGNHCQA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N011", "url": "https://www.orthodb.org/?gene=F1N011", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11334:SF61", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11334:SF61", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690422", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N011-1", "url": "https://www.uniprot.org/uniprotkb/F1N011-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEANGTSFVAEEPSNASTSGNTSVKDPRREIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSVDYALDYELSSGYYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSEGQTHSRGDCRAVIIFIAILSFLVFTPLMVVSSTILVVKIRKNSWASHSSKLYLVITVTIIIFFIFAMPMRLLYLLYYEYWSTFKNLHHVSLLFSTINSSANPFIYFFVGSSRKKRFKESLKVVLTRAFKDEMQPRQPEDHTATTATETVV", "length": 325, "header": "tr|F1N011-1|F1N011_BOVIN Isoform 1 of MAS1 proto-onco, G protein-coupled receptor OS=Bos taurus OX=9913 GN=MAS1 PE=3 SV=2 CANONICAL=F1N011-1" }, "isoforms": [ { "isoform_ac": "F1N011-1", "url": "https://www.uniprot.org/uniprotkb/F1N011/entry", "sequence": { "sequence": "MDEANGTSFVAEEPSNASTSGNTSVKDPRREIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSVDYALDYELSSGYYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSEGQTHSRGDCRAVIIFIAILSFLVFTPLMVVSSTILVVKIRKNSWASHSSKLYLVITVTIIIFFIFAMPMRLLYLLYYEYWSTFKNLHHVSLLFSTINSSANPFIYFFVGSSRKKRFKESLKVVLTRAFKDEMQPRQPEDHTATTATETVV", "length": 325, "header": "tr|F1N011-1|F1N011_BOVIN Isoform 1 of MAS1 proto-onco, G protein-coupled receptor OS=Bos taurus OX=9913 GN=MAS1 PE=3 SV=2 CANONICAL=F1N011-1" }, "locus": { "chromosome": "9", "start_pos": 96123617, "end_pos": 96122643, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044979.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044979.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042413.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042413.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783010", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783010", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480DGN1-1", "protein_name": "MAS1 proto-onco, G protein-coupled receptor", "gene_name": "MAS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDEANGTSFVTEGSSNASTSRNASAGDPRREIPMVHWVILSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSVDYALDYELSSGYYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSALVCALLWALSCLVTTMEYVMCIDREGQAHSRSDCRAVIIFIGVLSFAVFTPLMVVSSSILVVKIRKTAWASPSSKLYLVITVSIIVFFIFAVPMRLLYLLYYEYWSTFRNLHHVSLLFSTINSSANPFIYFFVGSSRKKRFKESLKVVLTRAFKDEMQPRRPGDATATPATETVV", "length": 325 }, "evidence": [ { "id": "F1N011", "url": "https://omabrowser.org/oma/group/F1N011/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P04201-1", "protein_name": "Proto-oncogene Mas", "gene_name": "MAS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV", "length": 325 }, "evidence": [ { "id": "F1N011", "url": "https://omabrowser.org/oma/group/F1N011/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P12526-1", "protein_name": "Proto-oncogene Mas", "gene_name": "Mas1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSTFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV", "length": 324 }, "evidence": [ { "id": "F1N011", "url": "https://omabrowser.org/oma/group/F1N011/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P30554-1", "protein_name": "Proto-oncogene Mas", "gene_name": "Mas1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSRSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV", "length": 324 }, "evidence": [ { "id": "F1N011", "url": "https://omabrowser.org/oma/group/F1N011/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" }, { "name": "angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure", "id": "GO:0002033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002033", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" }, { "name": "phospholipase C-activating angiotensin-activated signaling pathway", "id": "GO:0086097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086097", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "C-C chemokine receptor activity", "id": "GO:0016493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016493", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" }, { "name": "peptide binding", "id": "GO:0042277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042277", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" }, { "name": "angiotensin receptor activity", "id": "GO:0001595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001595", "evidence": [ { "database": "UniProtKB", "id": "F1N011", "url": "https://www.uniprot.org/uniprotkb/F1N011" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N011" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 280, "start_aa": "Glu", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 22, "end_pos": 24 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N017-1", "uniprot_ac": "F1N017", "uniprot_id": "F1N017_BOVIN", "mass": { "chemical_mass": 38337.0, "monoisotopic_mass": 38337.0 }, "refseq": { "ac": "NP_777005", "name": "POU domain, class 5, transcription factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, "gene_names": [ { "name": "POU5F1", "type": "recommended", "evidence": [ { "id": "F1N017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ] }, { "name": "OCT3", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "OCT4", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "OTF-3", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "POU5F1", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "oct-3", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "oct-4", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] } ], "protein_names": [ { "name": "POU domain protein", "type": "recommended", "evidence": [ { "id": "F1N017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N017/entry#names_and_taxonomy" } ] }, { "name": "Octamer-binding transcription factor 3", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "POU domain, class 5, transcription factor 1", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "octamer transcription factor 4", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] }, { "name": "octamer-binding protein 3", "type": "synonym", "evidence": [ { "id": "NP_777005", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ] } ], "function": [ { "annotation": "Analysis of CpG islands of bovine Leptin and POU5F1 genes in cloned bovine fetuses", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, { "database": "PubMed", "id": "16474211", "url": "https://glygen.org/publication/PubMed/16474211" } ] }, { "annotation": "CDX2 expression was aberrant in embryos lacking POU5F1 Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, { "database": "PubMed", "id": "29773834", "url": "https://glygen.org/publication/PubMed/29773834" } ] }, { "annotation": "In OCT4 KO morulae (day 5), approximately 70% of the nuclei were OCT4 positive, indicating that maternal OCT4 mRNA partially maintains OCT4 protein expression during early development.", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, { "database": "PubMed", "id": "29483258", "url": "https://glygen.org/publication/PubMed/29483258" } ] }, { "annotation": "In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, { "database": "PubMed", "id": "15229144", "url": "https://glygen.org/publication/PubMed/15229144" } ] }, { "annotation": "The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, { "database": "PubMed", "id": "17314316", "url": "https://glygen.org/publication/PubMed/17314316" } ] }, { "annotation": "The use of a clonal cell populations with low senescence level, normal karyotype, and highest POU5F1 expression levels did not improve embryo development rates or quality following SCNT. As previously suggested, this study supports the notion that levels of POU5F1 expression in the donor nucleus do not impact the Somatic cell nuclear transfer results.", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" }, { "database": "PubMed", "id": "28832180", "url": "https://glygen.org/publication/PubMed/28832180" } ] }, { "annotation": "Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017#function" }, { "database": "UniProtKB", "id": "ARBA00055862", "url": "https://www.uniprot.org/uniprotkb/ARBA00055862#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POU5F1", "url": "https://www.uniprot.org/uniprotkb/F1N017", "locus": { "chromosome": "23", "start_pos": 27988298, "end_pos": 27982599, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021111", "url": "https://www.ensembl.org/id/ENSBTAG00000021111" } ] } } ], "crossref": [ { "id": "F1N017", "url": "https://alphafold.ebi.ac.uk/entry/F1N017", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021111", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282316", "url": "https://www.ncbi.nlm.nih.gov/gene/282316", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282316", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282316", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPQPYEF", "url": "https://omabrowser.org/oma/group/CPQPYEF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N017", "url": "https://www.orthodb.org/?gene=F1N017", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11636", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11636:SF86", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636:SF86", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00157", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00157", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N017-1", "url": "https://www.uniprot.org/uniprotkb/F1N017-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWMSFQGPPGGSGIGPGVVPGAEVWGLPPCPPPYDLCGGMAYCAPQVGVGPVPPGGLETPQPEGEAGAGVESNSEGASPDPCAAPAGAPKLDKEKLEPNPEESQDIKALQKDLEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLESMFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYSQREDFEAAGSPFTGGPVSFPLAPGPHFGTPGYGGPHFTTLYSSVPFPEGEAFPSVSVTALGSPMHSN", "length": 360, "header": "tr|F1N017-1|F1N017_BOVIN Isoform 1 of POU domain protein OS=Bos taurus OX=9913 GN=POU5F1 PE=3 SV=1 CANONICAL=F1N017-1" }, "isoforms": [ { "isoform_ac": "F1N017-1", "url": "https://www.uniprot.org/uniprotkb/F1N017/entry", "sequence": { "sequence": "MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWMSFQGPPGGSGIGPGVVPGAEVWGLPPCPPPYDLCGGMAYCAPQVGVGPVPPGGLETPQPEGEAGAGVESNSEGASPDPCAAPAGAPKLDKEKLEPNPEESQDIKALQKDLEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLESMFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYSQREDFEAAGSPFTGGPVSFPLAPGPHFGTPGYGGPHFTTLYSSVPFPEGEAFPSVSVTALGSPMHSN", "length": 360, "header": "tr|F1N017-1|F1N017_BOVIN Isoform 1 of POU domain protein OS=Bos taurus OX=9913 GN=POU5F1 PE=3 SV=1 CANONICAL=F1N017-1" }, "locus": { "chromosome": "23", "start_pos": 27987294, "end_pos": 27982798, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028122.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028122.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028122.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028122.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Pluripotent lineage definition in bovine embryos by Oct4 transcript localization.", "journal": "Biology of reproduction", "date": "2004-11", "authors": "Kurosaka Satoshi, Eckardt Sigrid, McLaughlin K John", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ], "reference": [ { "type": "PubMed", "id": "15229144", "url": "https://glygen.org/publication/PubMed/15229144" } ] }, { "title": "Epigenetic characterization of the CpG islands of bovine Leptin and POU5F1 genes in cloned bovine fetuses.", "journal": "The Journal of reproduction and development", "date": "2006-04", "authors": "Kremenskoy Maksym, Kremenska Yuliya, Suzuki Masako, Imai Kei, Takahashi Seiya, Hashizume Kazuyoshi, Yagi Shintaro, Shiota Kunio", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ], "reference": [ { "type": "PubMed", "id": "16474211", "url": "https://glygen.org/publication/PubMed/16474211" } ] }, { "title": "Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle.", "journal": "Biology of reproduction", "date": "2007-06", "authors": "Wuensch Annegret, Habermann Felix A, Kurosaka Satoshi, Klose Regina, Zakhartchenko Valeri, Reichenbach Horst-Dieter, Sinowatz Fred, McLaughlin K John, Wolf Eckhard", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ], "reference": [ { "type": "PubMed", "id": "17314316", "url": "https://glygen.org/publication/PubMed/17314316" } ] }, { "title": "Effect of POU5F1 Expression Level in Clonal Subpopulations of Bovine Fibroblasts Used as Nuclear Donors for Somatic Cell Nuclear Transfer.", "journal": "Cellular reprogramming", "date": "2017-10", "authors": "S\u00e1 Andr\u00e9 Luiz, Sampaio Rafael V, da Costa Almeida Nath\u00e1lia Nogueira, Sangalli Juliano Rodrigues, Brito Karynne Nazar\u00e9 Lins, Bressan Fabiana Fernandes, Rissino Joirge Dores, do Socorro Damasceno Santos Simone, Meirelles Flavio Vieira, Ohashi Ot\u00e1vio Mitio, Dos Santos Miranda Moys\u00e9s", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ], "reference": [ { "type": "PubMed", "id": "28832180", "url": "https://glygen.org/publication/PubMed/28832180" } ] }, { "title": "OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2018-03-13", "authors": "Simmet Kilian, Zakhartchenko Valeri, Philippou-Massier Julia, Blum Helmut, Klymiuk Nikolai, Wolf Eckhard", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ], "reference": [ { "type": "PubMed", "id": "29483258", "url": "https://glygen.org/publication/PubMed/29483258" } ] }, { "title": "Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation.", "journal": "Scientific reports", "date": "2018-05-17", "authors": "Daigneault Bradford W, Rajput Sandeep, Smith George W, Ross Pablo J", "evidence": [ { "database": "RefSeq", "id": "NP_777005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777005" } ], "reference": [ { "type": "PubMed", "id": "29773834", "url": "https://glygen.org/publication/PubMed/29773834" } ] } ], "pathway": [ { "id": "bta:282316", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282316", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HQN4-1", "protein_name": "POU domain protein", "gene_name": "Pou5f1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGHLASDFAFSPPPGGGDGSGGLEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVLGISPCPPPYEFCGGVAYCGPQVGLGLVPPVGLETSQPEGQSGAGVENDSEESSPGPCTARPIVPVKLEKVEPSPEESQDVKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLEKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENMFLQCPKPSLQQISAIADQLGLEKDVVRVWFCNRRQKGKRSSTDYTQREEYEAAGSPFPGGPVSFPLPPGPHFGAPSYGSPHFTTFYPAVPFPEGEALTSVPITALGSPMHSN", "length": 358 }, "evidence": [ { "id": "F1N017", "url": "https://omabrowser.org/oma/group/F1N017/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P20263-1", "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "Pou5f1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGHLASDFAFSPPPGGGDGSAGLEPGWVDPRTWLSFQGPPGGPGIGPGSEVLGISPCPPAYEFCGGMAYCGPQVGLGLVPQVGVETLQPEGQAGARVESNSEGTSSEPCADRPNAVKLEKVEPTPEESQDMKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSLKNMCKLRPLLEKWVEEADNNENLQEICKSETLVQARKRKRTSIENRVRWSLETMFLKCPKPSLQQITHIANQLGLEKDVVRVWFCNRRQKGKRSSIEYSQREEYEATGTPFPGGAVSFPLPPGPHFGTPGYGSPHFTTLYSVPFPEGEAFPSVPVTALGSPMHSN", "length": 352 }, "evidence": [ { "id": "F1N017", "url": "https://omabrowser.org/oma/group/F1N017/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q01860-1", "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "POU5F1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPGAVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN", "length": 360 }, "evidence": [ { "id": "F1N017", "url": "https://omabrowser.org/oma/group/F1N017/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N017", "url": "https://www.uniprot.org/uniprotkb/F1N017" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N017-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 360, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N017-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N017" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N017" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 228, "end_pos": 288, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N017" }, { "id": "PS51179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "POU-specific", "eco_id": "ECO_0000259", "start_pos": 138, "end_pos": 212, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N018-1", "uniprot_ac": "F1N018", "uniprot_id": "F1N018_BOVIN", "mass": { "chemical_mass": 56595.0, "monoisotopic_mass": 56595.0 }, "refseq": {}, "gene_names": [ { "name": "ACKR1", "type": "recommended", "evidence": [ { "id": "F1N018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ] } ], "protein_names": [ { "name": "Atypical chemokine receptor 1", "type": "recommended", "evidence": [ { "id": "F1N018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N018/entry#names_and_taxonomy" } ] }, { "name": "Duffy antigen/chemokine receptor", "type": "synonym", "evidence": [ { "id": "F1N018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N018/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018#function" }, { "database": "UniProtKB", "id": "RU368070", "url": "https://www.uniprot.org/uniprotkb/RU368070#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACKR1", "url": "https://www.uniprot.org/uniprotkb/F1N018", "locus": { "chromosome": "3", "start_pos": 10526128, "end_pos": 10528389, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003220", "url": "https://www.ensembl.org/id/ENSBTAG00000003220" } ] } } ], "crossref": [ { "id": "F1N018", "url": "https://alphafold.ebi.ac.uk/entry/F1N018", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003220", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003220", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15010", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15010", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VWYSSAF", "url": "https://omabrowser.org/oma/group/VWYSSAF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N018", "url": "https://www.orthodb.org/?gene=F1N018", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14181:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14181:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N018-1", "url": "https://www.uniprot.org/uniprotkb/F1N018-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDTQGAPTQTHTSQVAGITWIQPTSTTNTPSHKHVTFELSFLGSSSRGWRNSESHQLPFPSNFPAHLLPPSHTSPLAPSSFLVLGESLCAGKPPGFSASLSTFRKTWSPPFSFPECGSSPADSSLKTGSPWGQCRKWSWGSDRQWAWGKHFLNALPTPWPCPGLMPSLVPGAYLGTTATDRTTPAHLSARPAPSSIMGNCLYPVADDNSTKLAIKEDFLIDFPEDYYPDYNETDVEAAAPCHSCSLLNYSSLPFFILVSILGILASGTILYALLRPLFRWQLYQDRSTLVQLAVGSALFSIVVPILARGLSGALITSLCHLAHLVAYGSAFAQALLIGYHACLGPQLGAGQVPGLRLGVTVGLWGVAALLSLPVVLGSDTSQGLCTVTFSGEWETLRYIHAAACFAIFVLLPLGLLGTKGLKTVLGRAPCPWVDVLWVWFIFWWPQGMTLGLDSLVRSKAIVVSTCPAQQALDMLLDVAEALAILHCVATPLLLAWVCYQATHTSPPSLPLPTTQTSHLDTFGGKS", "length": 527, "header": "tr|F1N018-1|F1N018_BOVIN Isoform 1 of Atypical chemokine receptor 1 OS=Bos taurus OX=9913 GN=ACKR1 PE=3 SV=2 CANONICAL=F1N018-1" }, "isoforms": [ { "isoform_ac": "F1N018-1", "url": "https://www.uniprot.org/uniprotkb/F1N018/entry", "sequence": { "sequence": "MNDTQGAPTQTHTSQVAGITWIQPTSTTNTPSHKHVTFELSFLGSSSRGWRNSESHQLPFPSNFPAHLLPPSHTSPLAPSSFLVLGESLCAGKPPGFSASLSTFRKTWSPPFSFPECGSSPADSSLKTGSPWGQCRKWSWGSDRQWAWGKHFLNALPTPWPCPGLMPSLVPGAYLGTTATDRTTPAHLSARPAPSSIMGNCLYPVADDNSTKLAIKEDFLIDFPEDYYPDYNETDVEAAAPCHSCSLLNYSSLPFFILVSILGILASGTILYALLRPLFRWQLYQDRSTLVQLAVGSALFSIVVPILARGLSGALITSLCHLAHLVAYGSAFAQALLIGYHACLGPQLGAGQVPGLRLGVTVGLWGVAALLSLPVVLGSDTSQGLCTVTFSGEWETLRYIHAAACFAIFVLLPLGLLGTKGLKTVLGRAPCPWVDVLWVWFIFWWPQGMTLGLDSLVRSKAIVVSTCPAQQALDMLLDVAEALAILHCVATPLLLAWVCYQATHTSPPSLPLPTTQTSHLDTFGGKS", "length": 527, "header": "tr|F1N018-1|F1N018_BOVIN Isoform 1 of Atypical chemokine receptor 1 OS=Bos taurus OX=9913 GN=ACKR1 PE=3 SV=2 CANONICAL=F1N018-1" }, "locus": { "chromosome": "3", "start_pos": 10528190, "end_pos": 10526184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004179.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004179.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004179.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004179.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZL85-1", "protein_name": "Atypical chemokine receptor 1", "gene_name": "Ackr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNCLHPVERFSVDNSRTQFTFENWNYSYEDNASYELTDDYNLTGAAPCYSCNLLDSSSLPFFILTSVLGLLASGGILFTILRPFFHWQICPSWPILAQLAVGSALFSISVTILAPGLYSAHSTALCNLGYWAWYTAAFAQALFIGCYVFLNPSLNIVQIPGLTLGLTVGLWGAAALLGLPVALASDVYDGLCTLPSYRNLETLKYIHSAICFTIFTVLPLTLLAAKGLKTALGKGPGPWVSVLWLWFIFWWPHGMVLMFDALVRSKAMLLQTCQSQKMLDVMLDVAEALAMLHCVATPLLLALFCHQTTRRSLPSLSLPAR", "length": 322 }, "evidence": [ { "id": "F1N018", "url": "https://omabrowser.org/oma/group/F1N018/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H809-1", "protein_name": "Atypical chemokine receptor 1", "gene_name": "Ackr1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGNCLHPVETSFSLDENGSQFSSEFWIYSYEDNATYEVMDNFSIGAAAPCYSCNLLDSSSLPFFILTSVLGVLASGTVLFAILKPLSHWQICPSWPILAQLAVGSGLFSFAVPVLAPGLNTAHSTGLCFLGYWIWYTSAFAQALLIGCYACLTPRLGIGQIRSHTLGLTVGLWGAALLLGLPVTLASDVYNGLCTLASNKHLEALKFTHSAICFTIFTVLPLALLAAKGVKKALSKGPGPWVSVLWIWFIFWWPHGMVLLYDAFVRSKTVHLQSCQSQKILDVMLNLAEALAVLHCVATPLLLALFCYQTTRRSLPSLSLPARQSCHTDAFAVKS", "length": 335 }, "evidence": [ { "id": "F1N018", "url": "https://omabrowser.org/oma/group/F1N018/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q16570-1", "protein_name": "Atypical chemokine receptor 1", "gene_name": "ACKR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNCLHRAELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYGANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGSTRSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQVPGLTLGLTVGIWGVAALLTLPVTLASGASGGLCTLIYSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKLLLLSTCLAQQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGSKS", "length": 336 }, "evidence": [ { "id": "F1N018", "url": "https://omabrowser.org/oma/group/F1N018/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QUI6-1", "protein_name": "Atypical chemokine receptor 1", "gene_name": "Ackr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNCLYPVETLSLDKNGTQFTFDSWNYSFEDNYSYELSSDYSLTPAAPCYSCNLLDRSSLPFFMLTSVLGMLASGSILFAILRPFFHWQICPSWPILAELAVGSALFSIAVPILAPGLHSAHSTALCNLGYWVWYTSAFAQALLIGCYACLNPRLNIGQLRGFTLGLSVGLWGAAALSGLPVALASDVYNGFCTFPSSRDMEALKYTHYAICFTIFTVLPLTLLAAKGLKIALSKGPGPWVSVLWIWFIFWWPHGMVLIFDALVRSKTVLLYTCQSQKILDAMLNVTEALSMLHCVATPLLLALFCHQTTRRSLSSLSLPTRQASQMDALAGKS", "length": 334 }, "evidence": [ { "id": "F1N018", "url": "https://omabrowser.org/oma/group/F1N018/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" }, { "name": "C-C chemokine binding", "id": "GO:0019957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019957", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" }, { "name": "chemokine-mediated signaling pathway", "id": "GO:0070098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070098", "evidence": [ { "database": "UniProtKB", "id": "F1N018", "url": "https://www.uniprot.org/uniprotkb/F1N018" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N018-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 527, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N018-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N018" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 209, "end_pos": 211 }, { "start_pos": 232, "end_pos": 234 }, { "start_pos": 249, "end_pos": 251 }, { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N030-1", "uniprot_ac": "F1N030", "uniprot_id": "F1N030_BOVIN", "mass": { "chemical_mass": 26555.0, "monoisotopic_mass": 26555.0 }, "refseq": {}, "gene_names": [ { "name": "EIF4E1B", "type": "recommended", "evidence": [ { "id": "F1N030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N030" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 4E family member 1B", "type": "synonym", "evidence": [ { "id": "F1N030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N030/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N030", "url": "https://www.uniprot.org/uniprotkb/F1N030" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF4E1B", "url": "https://www.uniprot.org/uniprotkb/F1N030", "locus": { "chromosome": "7", "start_pos": 38115276, "end_pos": 38111188, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003103", "url": "https://www.ensembl.org/id/ENSBTAG00000003103" } ] } } ], "crossref": [ { "id": "F1N030", "url": "https://alphafold.ebi.ac.uk/entry/F1N030", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003103", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003103", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11960", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11960", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11960:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11960:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N030", "url": "https://www.uniprot.org/uniprotkb/F1N030", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N030-1", "url": "https://www.uniprot.org/uniprotkb/F1N030-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGCPWSPGYSMAAARPAEEAEDGIQKWKKEDEKEEEEAGAGPCMGEEALRKTPEEGKPDLHPLLNRWALWFFKNDRSRAWQNNLHRVTKFNTVEDFWAIYNNIQLASKLSSGCDYALFKDGIKPMWEDSRNKRGGRWLVSLTKQQRHIELDHLWLETLLCLIGESFGEHSQEVCGAVINIRAKGDKIAVWTREAENQKACYTLGVSTKSAWASPQRPSLGTRPTQTQPPRATP", "length": 234, "header": "tr|F1N030-1|F1N030_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4E family member 1B OS=Bos taurus OX=9913 GN=EIF4E1B PE=3 SV=4 CANONICAL=F1N030-1" }, "isoforms": [ { "isoform_ac": "F1N030-1", "url": "https://www.uniprot.org/uniprotkb/F1N030/entry", "sequence": { "sequence": "MAGCPWSPGYSMAAARPAEEAEDGIQKWKKEDEKEEEEAGAGPCMGEEALRKTPEEGKPDLHPLLNRWALWFFKNDRSRAWQNNLHRVTKFNTVEDFWAIYNNIQLASKLSSGCDYALFKDGIKPMWEDSRNKRGGRWLVSLTKQQRHIELDHLWLETLLCLIGESFGEHSQEVCGAVINIRAKGDKIAVWTREAENQKACYTLGVSTKSAWASPQRPSLGTRPTQTQPPRATP", "length": 234, "header": "tr|F1N030-1|F1N030_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4E family member 1B OS=Bos taurus OX=9913 GN=EIF4E1B PE=3 SV=4 CANONICAL=F1N030-1" }, "locus": { "chromosome": "7", "start_pos": 38114272, "end_pos": 38111387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004037.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004037.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004037.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004037.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "F1N030", "url": "https://www.uniprot.org/uniprotkb/F1N030" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "eukaryotic translation initiation factor 4F complex", "id": "GO:0016281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016281", "evidence": [ { "database": "UniProtKB", "id": "F1N030", "url": "https://www.uniprot.org/uniprotkb/F1N030" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA 7-methylguanosine cap binding", "id": "GO:0000340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000340", "evidence": [ { "database": "UniProtKB", "id": "F1N030", "url": "https://www.uniprot.org/uniprotkb/F1N030" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "F1N030", "url": "https://www.uniprot.org/uniprotkb/F1N030" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N030-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N030-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N030" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N046-1", "uniprot_ac": "F1N046", "uniprot_id": "F1N046_BOVIN", "mass": { "chemical_mass": 32709.0, "monoisotopic_mass": 32709.0 }, "refseq": { "ac": "NP_001376917", "name": "olfactory receptor family 2 subfamily H member 10", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376917" }, "gene_names": [ { "name": "OR2H10", "type": "recommended", "evidence": [ { "id": "F1N046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N046" } ] }, { "name": "OR2H10", "type": "synonym", "evidence": [ { "id": "NP_001376917", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376917" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N046/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 2 subfamily H member 10", "type": "synonym", "evidence": [ { "id": "NP_001376917", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376917" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376917" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2H10", "url": "https://www.uniprot.org/uniprotkb/F1N046", "locus": { "chromosome": "7", "start_pos": 40719319, "end_pos": 40720191, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039986", "url": "https://www.ensembl.org/id/ENSBTAG00000039986" } ] } } ], "crossref": [ { "id": "F1N046", "url": "https://alphafold.ebi.ac.uk/entry/F1N046", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516409", "url": "https://www.ncbi.nlm.nih.gov/gene/516409", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516409", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516409", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376917", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N046-1", "url": "https://www.uniprot.org/uniprotkb/F1N046-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLFVTVSISYMVTLMGNTTIILLFHLDPHLHTPMYFFLTNLSLLDLCFTTSCIPQMLVHLRGPDKTISYLGCAVQLYIFLGLGAAECVLLLVMAFDRYVAVCRPLHYTVIMQPRVCHKLAFLVWTSGIFGTLVQSPTTMKLPFCHHHRVDDFVCEVPALIRLACGDTHSNELQISVIGSVFLMVPLLLILISYGHIARTVLAIQSHEGRRKAFQTCSSHLVVVFLFYCTVTAVYIQPRSHFSQKGGKFLTLFYTVVTPTLNPLIYTLRNKDMKGALKRLFGKDRTSNVQ", "length": 290, "header": "tr|F1N046-1|F1N046_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2H10 PE=3 SV=4 CANONICAL=F1N046-1" }, "isoforms": [ { "isoform_ac": "F1N046-1", "url": "https://www.uniprot.org/uniprotkb/F1N046/entry", "sequence": { "sequence": "MTLFVTVSISYMVTLMGNTTIILLFHLDPHLHTPMYFFLTNLSLLDLCFTTSCIPQMLVHLRGPDKTISYLGCAVQLYIFLGLGAAECVLLLVMAFDRYVAVCRPLHYTVIMQPRVCHKLAFLVWTSGIFGTLVQSPTTMKLPFCHHHRVDDFVCEVPALIRLACGDTHSNELQISVIGSVFLMVPLLLILISYGHIARTVLAIQSHEGRRKAFQTCSSHLVVVFLFYCTVTAVYIQPRSHFSQKGGKFLTLFYTVVTPTLNPLIYTLRNKDMKGALKRLFGKDRTSNVQ", "length": 290, "header": "tr|F1N046-1|F1N046_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2H10 PE=3 SV=4 CANONICAL=F1N046-1" }, "locus": { "chromosome": "7", "start_pos": 40720191, "end_pos": 40719322, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056094.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056094.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047582.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047582.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516409", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516409", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N046", "url": "https://www.uniprot.org/uniprotkb/F1N046" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N046-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N046-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N046" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N046", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N046" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 266, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 41, "end_pos": 43 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N058-1", "uniprot_ac": "F1N058", "uniprot_id": "F1N058_BOVIN", "mass": { "chemical_mass": 23978.0, "monoisotopic_mass": 23978.0 }, "refseq": {}, "gene_names": [ { "name": "ROPN1", "type": "recommended", "evidence": [ { "id": "F1N058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ] } ], "protein_names": [ { "name": "Rhophilin associated tail protein 1", "type": "synonym", "evidence": [ { "id": "F1N058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N058/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058#function" }, { "database": "UniProtKB", "id": "ARBA00037541", "url": "https://www.uniprot.org/uniprotkb/ARBA00037541#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ROPN1", "url": "https://www.uniprot.org/uniprotkb/F1N058", "locus": { "chromosome": "1", "start_pos": 68349821, "end_pos": 68384919, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006947", "url": "https://www.ensembl.org/id/ENSBTAG00000006947" } ] } } ], "crossref": [ { "id": "F1N058", "url": "https://alphafold.ebi.ac.uk/entry/F1N058", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006947", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23019", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23019", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR047844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QWASDYF", "url": "https://omabrowser.org/oma/group/QWASDYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N058", "url": "https://www.orthodb.org/?gene=F1N058", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14952:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14952:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N058-1", "url": "https://www.uniprot.org/uniprotkb/F1N058-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQTDKQICIPPELPELLKQFTKAAIRSQPQDLIQWAAEYFGAMSRGEIPPVRERSERVALSNWAELTPELLKILHSRVGGRLIVHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSDHDSGPPRIPFSTFQFLYTYIAEVDGEISASHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212, "header": "tr|F1N058-1|F1N058_BOVIN Isoform 1 of Rhophilin associated tail protein 1 OS=Bos taurus OX=9913 GN=ROPN1 PE=3 SV=1 CANONICAL=F1N058-1" }, "isoforms": [ { "isoform_ac": "F1N058-1", "url": "https://www.uniprot.org/uniprotkb/F1N058/entry", "sequence": { "sequence": "MPQTDKQICIPPELPELLKQFTKAAIRSQPQDLIQWAAEYFGAMSRGEIPPVRERSERVALSNWAELTPELLKILHSRVGGRLIVHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSDHDSGPPRIPFSTFQFLYTYIAEVDGEISASHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212, "header": "tr|F1N058-1|F1N058_BOVIN Isoform 1 of Rhophilin associated tail protein 1 OS=Bos taurus OX=9913 GN=ROPN1 PE=3 SV=1 CANONICAL=F1N058-1" }, "locus": { "chromosome": "1", "start_pos": 68360827, "end_pos": 68349953, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009113.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009113.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009113.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009113.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N699-1", "protein_name": "Ropporin-1A", "gene_name": "Ropn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPQTDKQVCIPPELPELLKQFTKAAIRTQPPDLIQWAAEYFGAMSRGEIPPVRERSEQVTLSNWAELTPELLKVLHSRVAGRLIIHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSGDHDGGPPRIPFSTFQFLYTYIAEVDGEISSSHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212 }, "evidence": [ { "id": "F1N058", "url": "https://omabrowser.org/oma/group/F1N058/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4KLL5-1", "protein_name": "Ropporin-1", "gene_name": "Ropn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQTDKQVCIPPELPELLKQFTKAAIRTQPPDLIQWAAEYFGAMSRGEIPPVRERSEQVPLSNWAELTPELLKVLHSRVGGRLIIHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSCDHDGGPPRIPFSTFQFLYTYIAEVDGEISSSHVTRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212 }, "evidence": [ { "id": "F1N058", "url": "https://omabrowser.org/oma/group/F1N058/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BZX4-1", "protein_name": "Ropporin-1B", "gene_name": "ROPN1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQTDKPTCIPPELPKMLKEFAKAAIRAQPQDLIQWGADYFEALSRGETPPVRERSERVALCNWAELTPELLKILHSQVAGRLIIRAEELAQMWKVVNLPTDLFNSVMNVGRFTEEIEWLKFLALACSALGVTITKTLKIVCEVLSCDHNGGLPRIPFSTFQFLYTYIAEVDGEICASHVSRMLNYIEQEVIGPDGLITVNDFTQNPRVWLE", "length": 212 }, "evidence": [ { "id": "F1N058", "url": "https://omabrowser.org/oma/group/F1N058/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ESG2-1", "protein_name": "Ropporin-1", "gene_name": "Ropn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQTDKQVCIPPELPELLKQFTKDAIRTQPPDLIQWAAEYFGAMSRGEIPPVRERSEQIPLSNWAELTPELLKVLHSRVAGRLIIHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSDHDGGPPRIPFSTFQFLYTYIAEVDGEISSSHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212 }, "evidence": [ { "id": "F1N058", "url": "https://omabrowser.org/oma/group/F1N058/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "sperm cytoplasmic droplet", "id": "GO:0097598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097598", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "F1N058", "url": "https://www.uniprot.org/uniprotkb/F1N058" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N058-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 212, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N058-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N058" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N080-1", "uniprot_ac": "F1N080", "uniprot_id": "F1N080_BOVIN", "mass": { "chemical_mass": 35702.0, "monoisotopic_mass": 35702.0 }, "refseq": { "ac": "NP_001377490", "name": "olfactory receptor family 2 subfamily T member 29", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377490" }, "gene_names": [ { "name": "OR2T29", "type": "recommended", "evidence": [ { "id": "F1N080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N080" } ] }, { "name": "OR2T29", "type": "synonym", "evidence": [ { "id": "NP_001377490", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377490" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N080/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2T29", "type": "synonym", "evidence": [ { "id": "NP_001377490", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377490" } ] }, { "name": "olfactory receptor family 2 subfamily T member 29", "type": "synonym", "evidence": [ { "id": "NP_001377490", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377490" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377490" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2T29", "url": "https://www.uniprot.org/uniprotkb/F1N080", "locus": { "chromosome": "7", "start_pos": 42235853, "end_pos": 42236806, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021098", "url": "https://www.ensembl.org/id/ENSBTAG00000021098" } ] } } ], "crossref": [ { "id": "F1N080", "url": "https://alphafold.ebi.ac.uk/entry/F1N080", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021098", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021098", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788323", "url": "https://www.ncbi.nlm.nih.gov/gene/788323", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788323", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788323", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ENTWVAN", "url": "https://omabrowser.org/oma/group/ENTWVAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N080", "url": "https://www.orthodb.org/?gene=F1N080", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001377490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377490", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N080-1", "url": "https://www.uniprot.org/uniprotkb/F1N080-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNSTWVANHTGQLDFILMGLFSQSKHPALLCVVIFVIFLMALSGNSILILLIHSNAHLQTPMYFFISQLSLMDVMYISVTVPKMLMDQVMGVNEISASECGMQMFLYLTLVGSEFFLLAAMAYDRYVAICHPLRYSILMSHRVCHILVSGCWFLGSVDGFMLTPVTMTFPFCKTREIHHFFCEVPALMKLSCSDTSLYETLMYLCCVLMLLIPVTVISSSYSFILLTIHRMNSAEGRKKAFTTCSSHMTVVILFFGAAIYTYMLPSSYHTPEKDMIVSAFYTILTPVLNPLIYSLRNKDVTGALKKMLNMGSVTIL", "length": 317, "header": "tr|F1N080-1|F1N080_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2T29 PE=3 SV=3 CANONICAL=F1N080-1" }, "isoforms": [ { "isoform_ac": "F1N080-1", "url": "https://www.uniprot.org/uniprotkb/F1N080/entry", "sequence": { "sequence": "MDNSTWVANHTGQLDFILMGLFSQSKHPALLCVVIFVIFLMALSGNSILILLIHSNAHLQTPMYFFISQLSLMDVMYISVTVPKMLMDQVMGVNEISASECGMQMFLYLTLVGSEFFLLAAMAYDRYVAICHPLRYSILMSHRVCHILVSGCWFLGSVDGFMLTPVTMTFPFCKTREIHHFFCEVPALMKLSCSDTSLYETLMYLCCVLMLLIPVTVISSSYSFILLTIHRMNSAEGRKKAFTTCSSHMTVVILFFGAAIYTYMLPSSYHTPEKDMIVSAFYTILTPVLNPLIYSLRNKDVTGALKKMLNMGSVTIL", "length": 317, "header": "tr|F1N080-1|F1N080_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2T29 PE=3 SV=3 CANONICAL=F1N080-1" }, "locus": { "chromosome": "7", "start_pos": 42236806, "end_pos": 42235856, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028103.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028103.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028103.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028103.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788323", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788323", "resource": "KEGG Pathway" }, { "id": "R-BTA-381753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "resource": "Reactome", "description": "Olfactory Signaling Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "M0R499-1", "protein_name": "Olfactory receptor", "gene_name": "Or2t47", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNYTGQFSDFTLLGFFSQYKYPTLLAGVIFVVFLMALSGNAFLILLILFDTQLHTPMYFFISQLSLMDMMYISVTVPKMLMDQVLGNHRISAAACGMQMFLYLSLGGSEFLLLAAMSYDRYVAICHPLRYPVLMNHRVCLLLLSVCWFLGSLDGFMLTPVTMTFPFCGSREIHHFFCEVPAVTKLSCSDTWLYETLMYVCCVLMILIPVTVISGSYSSILLTVLRMNSPEGRKKALATCSSHMTVVILFYGAAVYTYMLPTSFHTPEKDMVVSVFYTILTPLLNPLIYSFRNKNVTEAMKKLLGVSTLFQEIIK", "length": 315 }, "evidence": [ { "id": "F1N080", "url": "https://omabrowser.org/oma/group/F1N080/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M9MMJ7-1", "protein_name": "Olfactory receptor", "gene_name": "Or2t43", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNYTGQSYFTLVGLFSQSKHPALLAVVIFVVFLMSLSGNALLILLILSDTHLHTPMYFFISQLSLMDMMYISVTVPKMLMDRVLGNHKISAAACGMQMFLYMSLGGSEFLLLAAMSYDRYVAICHPLRYPVLMNHRVCLLLISTCWILGSLDGFMFTPVTMTFPFCGSREIHHFFCEAPAVTKLSCSDTWLYETLMYVCCVLMILIPVTVISGSYSSILLTVLRMNSAEGRKKALATCSSHMTVVTLFYGAAIYTYIFPASLHSPEKDMVVSVFYTILTPLLNPLIYSLRNKNVTEAMKKLLGIRLHFPETVK", "length": 314 }, "evidence": [ { "id": "F1N080", "url": "https://omabrowser.org/oma/group/F1N080/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N080", "url": "https://www.uniprot.org/uniprotkb/F1N080" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N080-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 317, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N080-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N080" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N080" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0B2-1", "uniprot_ac": "F1N0B2", "uniprot_id": "F1N0B2_BOVIN", "mass": { "chemical_mass": 130455.0, "monoisotopic_mass": 130455.0 }, "refseq": { "ac": "XP_024855850", "name": "phospholipid-transporting ATPase IB-like isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855850" }, "gene_names": [ { "name": "LOC536660", "type": "recommended", "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ] }, { "name": "LOC536660", "type": "synonym", "evidence": [ { "id": "XP_024855850", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855850" } ] } ], "protein_names": [ { "name": "Phospholipid-transporting ATPase", "type": "recommended", "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.1", "type": "synonym", "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2/entry#names_and_taxonomy" } ] }, { "name": "phospholipid-transporting ATPase IB-like isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024855850", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855850" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC536660", "url": "https://www.uniprot.org/uniprotkb/F1N0B2", "locus": {} } ], "crossref": [ { "id": "F1N0B2", "url": "https://alphafold.ebi.ac.uk/entry/F1N0B2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025428", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025428", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02073", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02073", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536660", "url": "https://www.ncbi.nlm.nih.gov/gene/536660", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YDDWYMV", "url": "https://omabrowser.org/oma/group/YDDWYMV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00122", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00122", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16212", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16212", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024855850", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855850", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38567", "url": "https://www.rhea-db.org/rhea/38567", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0B2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0B2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGWRQSLQGADVPMGRTIYLNEPLRNAFCENSISTAKYSMWSFLPRYLYLQFSKTANAFFLFITILQQIPDVSPTGKYTTLVPLLVILVISGIKEIVEDYKRHMADKLVNSKNTIVLRQNAWQMILWKEVNVGDIVKATNGQFLPADMVLISSSEPQATCFVATSNLDGETNLKIRQALSETATMKTEKQLSNLSGKIKCEEPNFHFNSFAGTLYLNEKSPISIGPDQVLLRGTQLKNTEWILGIVVYTGFETKFMQNAVKSPLKRSKVEKVTNMQILVLFLLLLVMSLVSCVGAIYWKDRYRAEPWYIGKSDYDYHSFGFDLLVFIILYHNLIPISLLVTLEIVKYIQALFINWDEDMHFKGSNVYAMARTSNLNEELGQVEYLFSDKTGTLTCNVMTFKKCSIAGITYGDLSSKSDDGAKGLSQSPCFISDAYEFNDPALLQNFENDHPTKEYIKEFLTLLCVCHTVVPEREGNNISYQASSPDEAALVKGAKKLGFVFTTRMPNSVTIEAMGEELTFEILNVLEFSSNRKRMSIIVRTPEGRLRLYCKGADSVIYERLSENSLFVEETLVHLENFAKEGLRTLCVAYIDLTEIEYEQWLVMYKKAITVVKDRMKTLEDCYDSIEKKFLLLGATAIEDRLQARVPETITSLLKANIKIWVLTGDKQETAINIAYSCKLLSGQMPRIQLNANSLEATQQVISQNCQDLGALLGKENDLALIIDGKTLKYALHVEVRKCFLNLALSCRTVLCCRLSPLQKAEIVDVVKKQVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMLATNNSDYAIAQFSYLEKLLLVHGAWNYFRVTKCILYCFYKNVVLYIIELWFAIVNGFSGQIIFERWCISLYNVIFTSLPPFTLGIFERCCSQESLLRYPQLYRISQTGDIFNIKVLWIQCINAIVHSFILFWLPAKMLEHDMVLQSGYTTDYLFLGNFIYTYVVVTVCLKAGLETMSWNKFTHFAIWGSIMIWLGFFAVYSSLWPTVPVAPEMTGQGSMALVCPHFWLGFFIVPIVCLIQNVAWKSIRNTCHRTLLEEVREMESSGVQVLRRDSVQSFKVEEVNLQRSSSPRPCQVIFRNNSVDLGAPHGYAFSQVERAVISQEELVRSYDTTKNKPQKTFSSATLE", "length": 1151, "header": "tr|F1N0B2-1|F1N0B2_BOVIN Isoform 1 of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=LOC536660 PE=3 SV=4 CANONICAL=F1N0B2-1" }, "isoforms": [ { "isoform_ac": "F1N0B2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0B2/entry", "sequence": { "sequence": "MGWRQSLQGADVPMGRTIYLNEPLRNAFCENSISTAKYSMWSFLPRYLYLQFSKTANAFFLFITILQQIPDVSPTGKYTTLVPLLVILVISGIKEIVEDYKRHMADKLVNSKNTIVLRQNAWQMILWKEVNVGDIVKATNGQFLPADMVLISSSEPQATCFVATSNLDGETNLKIRQALSETATMKTEKQLSNLSGKIKCEEPNFHFNSFAGTLYLNEKSPISIGPDQVLLRGTQLKNTEWILGIVVYTGFETKFMQNAVKSPLKRSKVEKVTNMQILVLFLLLLVMSLVSCVGAIYWKDRYRAEPWYIGKSDYDYHSFGFDLLVFIILYHNLIPISLLVTLEIVKYIQALFINWDEDMHFKGSNVYAMARTSNLNEELGQVEYLFSDKTGTLTCNVMTFKKCSIAGITYGDLSSKSDDGAKGLSQSPCFISDAYEFNDPALLQNFENDHPTKEYIKEFLTLLCVCHTVVPEREGNNISYQASSPDEAALVKGAKKLGFVFTTRMPNSVTIEAMGEELTFEILNVLEFSSNRKRMSIIVRTPEGRLRLYCKGADSVIYERLSENSLFVEETLVHLENFAKEGLRTLCVAYIDLTEIEYEQWLVMYKKAITVVKDRMKTLEDCYDSIEKKFLLLGATAIEDRLQARVPETITSLLKANIKIWVLTGDKQETAINIAYSCKLLSGQMPRIQLNANSLEATQQVISQNCQDLGALLGKENDLALIIDGKTLKYALHVEVRKCFLNLALSCRTVLCCRLSPLQKAEIVDVVKKQVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMLATNNSDYAIAQFSYLEKLLLVHGAWNYFRVTKCILYCFYKNVVLYIIELWFAIVNGFSGQIIFERWCISLYNVIFTSLPPFTLGIFERCCSQESLLRYPQLYRISQTGDIFNIKVLWIQCINAIVHSFILFWLPAKMLEHDMVLQSGYTTDYLFLGNFIYTYVVVTVCLKAGLETMSWNKFTHFAIWGSIMIWLGFFAVYSSLWPTVPVAPEMTGQGSMALVCPHFWLGFFIVPIVCLIQNVAWKSIRNTCHRTLLEEVREMESSGVQVLRRDSVQSFKVEEVNLQRSSSPRPCQVIFRNNSVDLGAPHGYAFSQVERAVISQEELVRSYDTTKNKPQKTFSSATLE", "length": 1151, "header": "tr|F1N0B2-1|F1N0B2_BOVIN Isoform 1 of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=LOC536660 PE=3 SV=4 CANONICAL=F1N0B2-1" }, "locus": { "chromosome": "12", "start_pos": 33308366, "end_pos": 33220226, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035719.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035719.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035589.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035589.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "I3LGF0-1", "protein_name": "Phospholipid-transporting ATPase", "gene_name": "LOC100625134", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGWRRPLQRTDVTKARTIYLNEPHRNSFCKNSISTAKYSLWSFLPRYLYLQFSKAANAFFLFITILQQIPDVSPTGKYTTLLPLLIILVISGIKEIVEDYVSLLLLNAPNPTALGNVWQVILWKEVNVGDIVKATDGQFLPADVVLISSSQPQATCYVATSNLDGETNLKIRQALLETAEIQTEKQLSSLSGKIECEGPNCHFNNFIGTLYLNGKSPVSIGPDQVLLRGTQLKNTDWIFGIVVYTGFETKFMQNAVQSPLKRSRVEKVTNVQILVLFLMLLVMALVSCVGAAFWNGTYGENTWYIGKKDHTSPSFWFDILMFIILYHNLIPISLLVTLEIVKSIQAMFINWDEDMHYERNDVYAMARTSSLNEELGQVKYLFSDKTGTLTCNIMTFKKCTIAGIIYGDRPCPITESSEFSDPKLLENFEEDHPTKEYIKEFLFLLSVCHTVVPERDGNNISYQASSPDEAALVKGAKKLGFVFTARTPYSVTIEAMGEEFTFQILNVLEFSSNRKRMSVIVRTPTGQLRLYCKGADSVIYERLSEDSLFVKETLTHLESFAREGLRTLCIAYIDLTELEYQQWLAMYEEVCTVVQDRAQSLEHCYDTIEKKFLLLGATAIEDRLQARVPETIANLLKANIRIWLLTGDKEETAVNIAYSCKLLSGHMLHIQLNANSLEATQQMIDQNCQDLGALLGKENDLALIIDGKTLKHALHFEVKKSFLNLALSCRAVLCCRLSPLQKAEIVDLVKSHVRAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSHLEKLLLVHGAWSYFRVTKCVLYCFYKNVVLYIIELWFAFVNGFSGQILFERWCISLYNVIFTSLPTITLGIFEQCCSQESLLRYPQLYTISQTGDIFNIKVLWIQCINAFVHSFILFWLPTKMLKHGNSFIVSNICQRYVVVTVCLKAGLETMSWNKFSHLAIWGSILIWLVFFTVYSFFWPTIPISPEMTGQASMVLACPYFWLGFFLVPIVCLIQNVIWKSNTCSRTLLEVVREMESSRGQELDCSGQEFEFLSPECSLYALCALTASLCFALAGGYAFSQVEHAVISQEELVRSYDTTKSKTRRTFSTAFSESIFE", "length": 1119 }, "evidence": [ { "id": "F1N0B2", "url": "https://omabrowser.org/oma/group/F1N0B2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" }, { "name": "ATPase-coupled intramembrane lipid transporter activity", "id": "GO:0140326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140326", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "F1N0B2", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1104, "end_pos": 1106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 807, "end_pos": 809, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38567", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "C7EXK4-1", "Q29449-1", "A0AAA9SM02-1", "A0A3Q1LM90-1", "A0AAA9RSX8-1", "A0A3Q1MQL3-1", "E1BPC3-1", "A0A3Q1M9T8-1", "A0A3Q1LWW8-1", "F1N0B2-1" ], "evidence": [ { "id": "38567", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38567" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LM90", "gene_name": "ATP11B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] } ] }, { "uniprot_ac": "A0A3Q1LWW8", "gene_name": "LOC112441535", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LWW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LWW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ] } ] }, { "uniprot_ac": "A0A3Q1M9T8", "gene_name": "ATP11A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1M9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T8" } ] } ] }, { "uniprot_ac": "A0A3Q1MQL3", "gene_name": "ATP8A1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1MQL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQL3" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1MQL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQL3" } ] } ] }, { "uniprot_ac": "A0AAA9RSX8", "gene_name": "ATP11C", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0AAA9RSX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSX8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9RSX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSX8" } ] } ] }, { "uniprot_ac": "A0AAA9SM02", "gene_name": "ATP8A2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0AAA9SM02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM02" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9SM02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM02" } ] } ] }, { "uniprot_ac": "C7EXK4", "gene_name": "ATP8A2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "C7EXK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C7EXK4" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "C7EXK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C7EXK4" } ] } ] }, { "uniprot_ac": "E1BPC3", "gene_name": "ATP8B1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "E1BPC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC3" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "E1BPC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC3" } ] } ] }, { "uniprot_ac": "F1N0B2", "gene_name": "LOC536660", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" } ] } ] }, { "uniprot_ac": "Q29449", "gene_name": "ATP8A1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "Q29449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29449" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "Q29449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29449" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0B2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1151, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0B2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0B2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PF00122", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00122" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P-type ATPase A", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 182, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PF16212", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16212" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P-type ATPase C-terminal", "eco_id": "ECO_0000259", "start_pos": 807, "end_pos": 1056, "start_aa": "Asn", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PF16209", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16209" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P-type ATPase N-terminal", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 81, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 388, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 388, "end_pos": 388, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 390, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 390, "end_pos": 390, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 780, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 780, "end_pos": 780, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0B2" }, { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 784, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 784, "end_pos": 784, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.6.2.1", "ec_name": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "7.6.2.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1104, "end_pos": 1106 }, { "start_pos": 193, "end_pos": 195 }, { "start_pos": 477, "end_pos": 479 }, { "start_pos": 807, "end_pos": 809 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0D7-1", "uniprot_ac": "F1N0D7", "uniprot_id": "F1N0D7_BOVIN", "mass": { "chemical_mass": 54409.0, "monoisotopic_mass": 54409.0 }, "refseq": { "ac": "NP_001193295", "name": "zinc finger protein ZIC 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193295" }, "gene_names": [ { "name": "ZIC2", "type": "recommended", "evidence": [ { "id": "F1N0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ] }, { "name": "ZIC2", "type": "synonym", "evidence": [ { "id": "NP_001193295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193295" } ] } ], "protein_names": [ { "name": "Zic family member 2 (odd-paired homolog, Drosophila)", "type": "synonym", "evidence": [ { "id": "NP_001193295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193295" } ] }, { "name": "Zic family member 2", "type": "synonym", "evidence": [ { "id": "F1N0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D7/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein ZIC 2", "type": "synonym", "evidence": [ { "id": "NP_001193295", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193295" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZIC2", "url": "https://www.uniprot.org/uniprotkb/F1N0D7", "locus": { "chromosome": "12", "start_pos": 76742911, "end_pos": 76738341, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025246", "url": "https://www.ensembl.org/id/ENSBTAG00000025246" } ] } } ], "crossref": [ { "id": "F1N0D7", "url": "https://alphafold.ebi.ac.uk/entry/F1N0D7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025246", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025246", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514433", "url": "https://www.ncbi.nlm.nih.gov/gene/514433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514433", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQYGPMN", "url": "https://omabrowser.org/oma/group/GQYGPMN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0D7", "url": "https://www.orthodb.org/?gene=F1N0D7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193295", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0D7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0D7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSTLSPAAAAAAAAAAAAAAVSAVHRSGGAGGSSGGGGGGGGGGGAGGGGGGGSSGGGSGTAGGHGGLSSNFNEWYV", "length": 525, "header": "tr|F1N0D7-1|F1N0D7_BOVIN Isoform 1 of Zic family member 2 OS=Bos taurus OX=9913 GN=ZIC2 PE=3 SV=3 CANONICAL=F1N0D7-1" }, "isoforms": [ { "isoform_ac": "F1N0D7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0D7/entry", "sequence": { "sequence": "MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSTLSPAAAAAAAAAAAAAAVSAVHRSGGAGGSSGGGGGGGGGGGAGGGGGGGSSGGGSGTAGGHGGLSSNFNEWYV", "length": 525, "header": "tr|F1N0D7-1|F1N0D7_BOVIN Isoform 1 of Zic family member 2 OS=Bos taurus OX=9913 GN=ZIC2 PE=3 SV=3 CANONICAL=F1N0D7-1" }, "locus": { "chromosome": "12", "start_pos": 76742284, "end_pos": 76738646, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035414.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035414.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035289.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035289.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514433", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514433", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PNB7-1", "protein_name": "Zic family member 2", "gene_name": "ZIC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLDAGPQFPALGVGTFARHHHSAAAEMQERELSLAAQNGFVDSAHMGAFKLNAGAHELSPGQSSAFTSQAPGYPAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGEAAAGGGQHGIFGPAAGGLHHPHTDAQSHLLFPGIHEQHGPHASQNVLNGQMRLGLPGEVFARSEQYRQVASPRTDPYAAAQLHNQYGPMNMNVGMNVAAHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCYWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSTNLSPAAAAAAAAAAAAAVTAAHRSGGGGGGGGSGGGGGGGHGGLSSNFNEWYV", "length": 478 }, "evidence": [ { "id": "F1N0D7", "url": "https://omabrowser.org/oma/group/F1N0D7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M7V7-1", "protein_name": "Zic family member 2", "gene_name": "Zic2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHASQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGAGSGSSGSGGGSAAGSAGQPEAIAASPPTSMNGTCEGPGLSPIPCSLIHRRPPKNPPRAP", "length": 536 }, "evidence": [ { "id": "F1N0D7", "url": "https://omabrowser.org/oma/group/F1N0D7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RP24-1", "protein_name": "Zic family member 2", "gene_name": "ZIC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLDAGPQFPAIGVSSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHSSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAAAVSAVHRGGGSSGGGAGGGSGGGSGGGGGGGAGGGGGGGSGGGSGTAGGHSSLSSNFNEWYV", "length": 532 }, "evidence": [ { "id": "F1N0D7", "url": "https://omabrowser.org/oma/group/F1N0D7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95409-1", "protein_name": "Zinc finger protein ZIC 2", "gene_name": "ZIC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV", "length": 532 }, "evidence": [ { "id": "F1N0D7", "url": "https://omabrowser.org/oma/group/F1N0D7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62520-1", "protein_name": "Zinc finger protein ZIC 2", "gene_name": "Zic2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPPEQHGPHASQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGAGSGSSGSGGGSAAGSGGGGGGAGGGGGGSSGGGSGTTGGHSGLSSNFNEWYV", "length": 530 }, "evidence": [ { "id": "F1N0D7", "url": "https://omabrowser.org/oma/group/F1N0D7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N0D7", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0D7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 525, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0D7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0D7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D7" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 304, "end_pos": 331, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 375, "end_pos": 377 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0E8-1", "uniprot_ac": "F1N0E8", "uniprot_id": "F1N0E8_BOVIN", "mass": { "chemical_mass": 58026.0, "monoisotopic_mass": 58026.0 }, "refseq": { "ac": "XP_002686193", "name": "potassium voltage-gated channel subfamily A member 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686193" }, "gene_names": [ { "name": "KCNA10", "type": "recommended", "evidence": [ { "id": "F1N0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ] }, { "name": "KCNA10", "type": "synonym", "evidence": [ { "id": "XP_002686193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686193" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily A member 10", "type": "recommended", "evidence": [ { "id": "F1N0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0E8/entry#names_and_taxonomy" } ] }, { "name": "Voltage-gated potassium channel subunit Kv1.8", "type": "synonym", "evidence": [ { "id": "F1N0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0E8/entry#names_and_taxonomy" } ] }, { "name": "potassium voltage-gated channel subfamily A member 10", "type": "synonym", "evidence": [ { "id": "XP_002686193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686193" } ] } ], "function": [ { "annotation": "Voltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane down their electrochemical gradient.", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8#function" }, { "database": "UniProtKB", "id": "ARBA00059742", "url": "https://www.uniprot.org/uniprotkb/ARBA00059742#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNA10", "url": "https://www.uniprot.org/uniprotkb/F1N0E8", "locus": { "chromosome": "3", "start_pos": 32923730, "end_pos": 32910256, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008322", "url": "https://www.ensembl.org/id/ENSBTAG00000008322" } ] } } ], "crossref": [ { "id": "F1N0E8", "url": "https://alphafold.ebi.ac.uk/entry/F1N0E8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008322", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008322", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18409", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18409", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538721", "url": "https://www.ncbi.nlm.nih.gov/gene/538721", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538721", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538721", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWRILIS", "url": "https://omabrowser.org/oma/group/NWRILIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0E8", "url": "https://www.orthodb.org/?gene=F1N0E8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002686193", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686193", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0E8-1", "url": "https://www.uniprot.org/uniprotkb/F1N0E8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDPTTPKGWPGSSPFSNWKTLINDSTSHETVFSKLPGDYIDSPGPETVVLNEGYQRVIINIAGLRFETQLRTLNQFPETLLGNREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARGVAVVSVLVVIISITIFCLETLPEFREDRELKVVRDPSLNMSKTVLSHTMFTDPFFMVESTCIVWFTFELVLRFMVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQSIPGEINKLLNSAGSRMGSTDSLSKTNGSCSTEKSRK", "length": 511, "header": "tr|F1N0E8-1|F1N0E8_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily A member 10 OS=Bos taurus OX=9913 GN=KCNA10 PE=3 SV=3 CANONICAL=F1N0E8-1" }, "isoforms": [ { "isoform_ac": "F1N0E8-1", "url": "https://www.uniprot.org/uniprotkb/F1N0E8/entry", "sequence": { "sequence": "MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDPTTPKGWPGSSPFSNWKTLINDSTSHETVFSKLPGDYIDSPGPETVVLNEGYQRVIINIAGLRFETQLRTLNQFPETLLGNREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARGVAVVSVLVVIISITIFCLETLPEFREDRELKVVRDPSLNMSKTVLSHTMFTDPFFMVESTCIVWFTFELVLRFMVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQSIPGEINKLLNSAGSRMGSTDSLSKTNGSCSTEKSRK", "length": 511, "header": "tr|F1N0E8-1|F1N0E8_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily A member 10 OS=Bos taurus OX=9913 GN=KCNA10 PE=3 SV=3 CANONICAL=F1N0E8-1" }, "locus": { "chromosome": "3", "start_pos": 32923601, "end_pos": 32922069, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010960.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010960.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042261.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042261.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538721", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538721", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AYB3-1", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "KCNA10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHVCGWKETEVALVNFDNSDELQEEPGYAAGFDPTTPKGRPGSSPFSNWKILINESTNHETAFSKLPGDCLDPPGPEPLVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEMSFYELGSEAMDQFREDEGFLKDPETLLPSNDIHRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSRNTSQTVLSHTLFTDPFFMVESTCIMWFTLELVLRFVVCPSKPDFFRNIMNIIDIISIIPYFATLVTELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQIIPGEIDKILNSVGSRRGSTDSLSKTNSGCSAEKSRK", "length": 511 }, "evidence": [ { "id": "F1N0E8", "url": "https://omabrowser.org/oma/group/F1N0E8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B2RQA1-1", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "Kcna10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDVCSWKEMEVALVNFDNSDEIHEEPGYATDFDPTSSKGRPGSSPFSNWRVLISDNTNHETAFSKIPGEYVDPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSINTNKTGLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKPNIPGELDKILNSMGSRMGSTESLNKTNGSCSAEKSRK", "length": 511 }, "evidence": [ { "id": "F1N0E8", "url": "https://omabrowser.org/oma/group/F1N0E8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZRW4-1", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "Kcna10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVCSWREMEVALVNFDNSDEIHEEPGYATDFDPTSSKGRPGSSPFSNWKVLISDNISHETAFSKIPGEYVDPPGSEPVVLNEGNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPTINTNKTGLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKPDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKPNIPGELDKILNSMGSRTGSTESLNKTNSSRSAEKSRK", "length": 511 }, "evidence": [ { "id": "F1N0E8", "url": "https://omabrowser.org/oma/group/F1N0E8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I685-1", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "Kcna10", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDVCGWKEMEVALVNFDNSDEIHEEPGYAADLDPKGRPSSSPFPNWKVLISDSTNLETAFSKIPGEFVDPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPEIPLPTNDFHRQFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSINTNKTGLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPAEIDKILNSVGSRVGSTDSLNKTNGGCSTEKSRK", "length": 508 }, "evidence": [ { "id": "F1N0E8", "url": "https://omabrowser.org/oma/group/F1N0E8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q16322-1", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "KCNA10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK", "length": 511 }, "evidence": [ { "id": "F1N0E8", "url": "https://omabrowser.org/oma/group/F1N0E8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7T199-1", "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "KCNA10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMDVSSWKEMEVALVSFDNADQIVEDPCYSNDLSPASQSRKGHPSCANLLSNWRILINSENANNETIFSRFSAEFSEHLVGERVGMEEGDQRVIINIAGLRFETRLKTLNQFPETLLGDPEKRMRYFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEITFYELGDEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAARGVALVSVLVIVISIIIFCMETLPEFREEREYKSTQELSKNTTDTLLAHSTFTDPFFVIETACIIWFSFELFVRFIVCPSKTEFFKNIMNIIDIVSIIPYFVTLTTELIQQSELNGQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPQSHFSSIPDGFWWAVVTMTTVGYGDMCPTTLGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQILPGEVERILNSVVTGNDSMESLNKTNGGYPRDKAKK", "length": 516 }, "evidence": [ { "id": "F1N0E8", "url": "https://omabrowser.org/oma/group/F1N0E8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "pmid": "" }, { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "F1N0E8", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0E8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 511, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0E8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0E8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0E8" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 86, "end_pos": 186, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 256, "end_pos": 258 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 501, "end_pos": 503 }, { "start_pos": 54, "end_pos": 56 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0F3-1", "uniprot_ac": "F1N0F3", "uniprot_id": "F1N0F3_BOVIN", "mass": { "chemical_mass": 45120.0, "monoisotopic_mass": 45120.0 }, "refseq": { "ac": "NP_001421805", "name": "transforming growth factor beta regulator 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421805" }, "gene_names": [ { "name": "TBRG1", "type": "recommended", "evidence": [ { "id": "F1N0F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ] }, { "name": "TBRG1", "type": "synonym", "evidence": [ { "id": "NP_001421805", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421805" } ] } ], "protein_names": [ { "name": "Transforming growth factor beta regulator 1", "type": "synonym", "evidence": [ { "id": "F1N0F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0F3/entry#names_and_taxonomy" } ] }, { "name": "transforming growth factor beta regulator 1 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421805", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421805" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBRG1", "url": "https://www.uniprot.org/uniprotkb/F1N0F3", "locus": { "chromosome": "29", "start_pos": 28111910, "end_pos": 28100180, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009410", "url": "https://www.ensembl.org/id/ENSBTAG00000009410" } ] } } ], "crossref": [ { "id": "F1N0F3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0F3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009410", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009410", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507460", "url": "https://www.ncbi.nlm.nih.gov/gene/507460", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YYNDYHK", "url": "https://omabrowser.org/oma/group/YYNDYHK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0F3", "url": "https://www.orthodb.org/?gene=F1N0F3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22715", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22715", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22715:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22715:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05964", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05964", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05965", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05965", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421805", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0F3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0F3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLLGSLASSPRDPLQSSKARMKKLPKKSQNEKYRLKYLRLRRAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGDVQAAAPSHSSSLPLTYTVASSVGTLQGTGPVSGPSTGAEEPFGKKSKKEKKEKGKENNKLEVLKKTSKKKKMEAGARKPVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDETAIYPVGYCSTRVYASMRSPDQECLYTCQIKDGGTQPQFEIVPEDDPQNAIISSSADACHAELLKTISTAMGKLIPNLHPSGADFFGFSHPAIHNLIQSCPGARKCVNYQWVKFDVCKPGDSPPPQEQLENDIATSFEAFQRHTFDEDHSDPILQGSLDLPELQPTAFVSSYQPMFLTHEPLVDAHLQHLKSPSPCSPSQSSD", "length": 411, "header": "tr|F1N0F3-1|F1N0F3_BOVIN Isoform 1 of Transforming growth factor beta regulator 1 OS=Bos taurus OX=9913 GN=TBRG1 PE=4 SV=1 CANONICAL=F1N0F3-1" }, "isoforms": [ { "isoform_ac": "F1N0F3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0F3/entry", "sequence": { "sequence": "MSLLGSLASSPRDPLQSSKARMKKLPKKSQNEKYRLKYLRLRRAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGDVQAAAPSHSSSLPLTYTVASSVGTLQGTGPVSGPSTGAEEPFGKKSKKEKKEKGKENNKLEVLKKTSKKKKMEAGARKPVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDETAIYPVGYCSTRVYASMRSPDQECLYTCQIKDGGTQPQFEIVPEDDPQNAIISSSADACHAELLKTISTAMGKLIPNLHPSGADFFGFSHPAIHNLIQSCPGARKCVNYQWVKFDVCKPGDSPPPQEQLENDIATSFEAFQRHTFDEDHSDPILQGSLDLPELQPTAFVSSYQPMFLTHEPLVDAHLQHLKSPSPCSPSQSSD", "length": 411, "header": "tr|F1N0F3-1|F1N0F3_BOVIN Isoform 1 of Transforming growth factor beta regulator 1 OS=Bos taurus OX=9913 GN=TBRG1 PE=4 SV=1 CANONICAL=F1N0F3-1" }, "locus": { "chromosome": "29", "start_pos": 28111706, "end_pos": 28100378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030289.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030289.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030273.2", "url": "https://www.ensembl.org/id/ENSBTAP00000030273.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VH38-1", "protein_name": "Transforming growth factor beta regulator 1", "gene_name": "TBRG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLLGGLASSPRAPLQSSRARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVASSVGTVQGAGPISGPSTGAEEPFGKKSKKEKKEKGKENNKLEVLKKASKKKKMEGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMQHPDQECLYTCQIKDGGTGPQFEIVPEDDPQNAIVSSSADACHAELLKTISAAMGKLMPNMLPSGADFFGFSHPTIHNLIQSCPGARKCVSYQWVKFDVCKPGDGPPPQRQLEDDSATSFEAFQRQTFDEDHNDPILQGSLDLPELQPTAFVSSYQPMFLTHEPLIETHLQHLKSPSHCSPTQSSD", "length": 411 }, "evidence": [ { "id": "F1N0F3", "url": "https://omabrowser.org/oma/group/F1N0F3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7GZH7-1", "protein_name": "Transforming growth factor beta regulator 1 isoform X1", "gene_name": "Tbrg1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLLGGLASEPRTPLSHKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFDDGSFKSTKIFVKPEDVLNIEMENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEPQAPAPSHSSSLPLAYGVAGPVGTIQGAGPSTGAEEPFGKKSKKEKKEKGKENNKLEVLKKTSKKKKMEGGARKLVRSIALDPSGRPVFPIGLGGLTVYSLGEIITNRPGFHDESAIYPVGYCSTRVFASMKCPDQKCLYTCQVKDGGVQPQFEIVPEDDPQNTIVSSSADACYEELVRTISNATGKLMPNLLSCGAEFFGFSHPVIHNLIQSCPEAQNCVNHQWVKSDACKPRKGQLSQELTENDAAMSLEAFETQTFDDDHEDSILPGSLDLPELQHEAFVSSYQPEFLTHEPLVDTDLQDLKSPSQCSPMQSSD", "length": 428 }, "evidence": [ { "id": "F1N0F3", "url": "https://omabrowser.org/oma/group/F1N0F3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3UB74-1", "protein_name": "Transforming growth factor beta regulator 1", "gene_name": "Tbrg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVLSGLASEPRTPLSSKARMKRLPRKSQNEKYRLKYLRLRRAAKATVFENASICDEIARLEEKFLKAKEERRYLLKKLLQIHALTEGEPQAAAPSHSSSLPLPYGVTSSVGTMQGAGPSTGAEEPFAKKSKKEKKEKGKENSKLEVLKKTSKKKKMEGGARKLVRPIALDPSGQPVFPIGLGGLTVYSLGEIITNRPGFHDENAIYPVGYCSTRVYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNTIVGSSADACYEELLRAISATTGKLMPNPLSCGADFFGFSHPTIHNLIQSCPEAQNCVNYQWVKFDACKPRKGQLSQELPENDATMSLEAFQTQTFDDDHDDSILPGSLDLPELQHEAFVSSYQPEFLTHEPLVDTDLQHLKSPSQCSPIQSSD", "length": 406 }, "evidence": [ { "id": "F1N0F3", "url": "https://omabrowser.org/oma/group/F1N0F3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3YBR2-1", "protein_name": "Transforming growth factor beta regulator 1", "gene_name": "TBRG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVASSVGTIQGAGPISGPSTGAEEPFGKKTKKEKKEKGKENNKLEVLKKTCKKKKMAGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPEGLPENDAAMSFEAFQRQIFDEDQNDPLLPGSLDLPELQPAAFVSSYQPMYLTHEPLVDTHLQHLKSPSQGSPIQSSD", "length": 411 }, "evidence": [ { "id": "F1N0F3", "url": "https://omabrowser.org/oma/group/F1N0F3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5PQK8-1", "protein_name": "Transforming growth factor beta regulator 1", "gene_name": "Tbrg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVLSGLASEPRTPLSSKARMKRLPKKNQNEKYRLKYLRLRRAAKATVFENAAVCDEIARLEEKFLKAKEERRYLLKKLLQIHALTEGEPQAAAPSHSSSLPLAYGVTSSVGTIQGAGPSTGAEEPFAKKSKKEKKEKGKENSKLEVLKKTSKRKKMEGGARKLVRPIALDPSGQPVFPIGLGGLTVYSLGEIITNRPGFHDENAIYPVGYCSTRVYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPRNTIVGSSADACYEELLRAISAATGKLMPNPLSCGADFFGFSHPTIHNLIQSCPEAQNCVNYQWVKFDACKPRKGQLSQELPENDAAMSLEAFPTQTFDDDHEDSILPGSLDLPELQHEAFVSSYQPEFLTHEPLVDTDLQHLKSPSQCSPIQSSD", "length": 406 }, "evidence": [ { "id": "F1N0F3", "url": "https://omabrowser.org/oma/group/F1N0F3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein localization to nucleoplasm", "id": "GO:1990173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990173", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N0F3", "url": "https://www.uniprot.org/uniprotkb/F1N0F3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0F3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 411, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0F3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0F3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0F7-1", "uniprot_ac": "F1N0F7", "uniprot_id": "F1N0F7_BOVIN", "mass": { "chemical_mass": 48971.0, "monoisotopic_mass": 48971.0 }, "refseq": { "ac": "NP_001180152", "name": "eukaryotic translation initiation factor 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180152" }, "gene_names": [ { "name": "EIF5", "type": "recommended", "evidence": [ { "id": "F1N0F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ] }, { "name": "EIF5", "type": "synonym", "evidence": [ { "id": "NP_001180152", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180152" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 5", "type": "recommended", "evidence": [ { "id": "F1N0F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0F7/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 5", "type": "synonym", "evidence": [ { "id": "NP_001180152", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180152" } ] } ], "function": [ { "annotation": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7#function" }, { "database": "UniProtKB", "id": "ARBA00053999", "url": "https://www.uniprot.org/uniprotkb/ARBA00053999#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF5", "url": "https://www.uniprot.org/uniprotkb/F1N0F7", "locus": { "chromosome": "21", "start_pos": 67997279, "end_pos": 67987965, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016282", "url": "https://www.ensembl.org/id/ENSBTAG00000016282" } ] } } ], "crossref": [ { "id": "F1N0F7", "url": "https://alphafold.ebi.ac.uk/entry/F1N0F7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016282", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016282", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11561", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11561", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504752", "url": "https://www.ncbi.nlm.nih.gov/gene/504752", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504752", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504752", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YRYKMEK", "url": "https://omabrowser.org/oma/group/YRYKMEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0F7", "url": "https://www.orthodb.org/?gene=F1N0F7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23001:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23001:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01873", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01873", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001180152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180152", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0F7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0F7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSSTGKKEKEKKNRKGKDKENGSVSSSETPPPPPNEISPPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKTSKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEDDDEDENIEVVYSKTASVPKVEAVKSDNKDDDIDIDAI", "length": 429, "header": "tr|F1N0F7-1|F1N0F7_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5 OS=Bos taurus OX=9913 GN=EIF5 PE=3 SV=1 CANONICAL=F1N0F7-1" }, "isoforms": [ { "isoform_ac": "F1N0F7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0F7/entry", "sequence": { "sequence": "MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSSTGKKEKEKKNRKGKDKENGSVSSSETPPPPPNEISPPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKTSKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEDDDEDENIEVVYSKTASVPKVEAVKSDNKDDDIDIDAI", "length": 429, "header": "tr|F1N0F7-1|F1N0F7_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5 OS=Bos taurus OX=9913 GN=EIF5 PE=3 SV=1 CANONICAL=F1N0F7-1" }, "locus": { "chromosome": "21", "start_pos": 67994488, "end_pos": 67989561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030275.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030275.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030260.3", "url": "https://www.ensembl.org/id/ENSBTAP00000030260.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504752", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504752", "resource": "KEGG Pathway" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A7Q7-1", "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "EIF5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGTVSSSETPPPPPPNEINPPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEDDDEDENIEVVYSKTASVPKVEAVKSDNKDDDIDIDAI", "length": 430 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P38431-1", "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "TIF5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSINICRDNHDPFYRYKMPPIQAKVEGRGNGIKTAVLNVADISHALNRPAPYIVKYFGFELGAQTSISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSCKNPETEIIITKDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVSGSKKKKKAATASANVRGGGLSISDIAQGKSQNAPSDGTGSSTPQHHDEDEDELSRQIKAAASTLEDIEVKDDEWAVDMSEEAIRARAKELEVNSELTQLDEYGEWILEQAGEDKENLPSDVELYKKAAELDVLNDPKIGCVLAQCLFDEDIVNEIAEHNAFFTKILVTPEYEKNFMGGIERFLGLEHKDLIPLLPKILVQLYNNDIISEEEIMRFGTKSSKKFVPKEVSKKVRRAAKPFITWLETAESDDDEEDDE", "length": 405 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P55010-1", "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "EIF5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPPPPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTIEERVNILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKAASVPKVETVKSDNKDDDIDIDAI", "length": 431 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P59325-1", "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "Eif5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEKKNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKEIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI", "length": 429 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q07205-1", "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "Eif5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEKKNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKDIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI", "length": 429 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9S825-1", "protein_name": "Probable eukaryotic translation initiation factor 5-2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MALQNIGASNRNDAFYRYKMPKMVTKTEGKGNGIKTNIINNVEIAKALARPPSYTTKYFGCELGAQSKFDEKTGTSLVNGAHNTSKLAGLLENFIKKFVQCYGCGNPETEIIITKTQMVNLKCAACGFISEVDMRDKLTNFILKNPPEQKKVSKDKKAMRKAEKERLKEGELADEEQRKLKAKKKALSNGKDSKTSKNHSSDEDISPKHDENALEVDEDEDDDDGVEWQTDTSREAAEKRMMEQLSAKTAEMVMLSAMEVEEKKAPKSKSNGNVVKTENPPPQEKNLVQDMKEYLKKGSPISALKSFISSLSEPPQDIMDALFNALFDGVGKGFAKEVTKKKNYLAAAATMQEDGSQMHLLNSIGTFCGKNGNEEALKEVALVLKALYDQDIIEEEVVLDWYEKGLTGADKSSPVWKNVKPFVEWLQSAESESEEED", "length": 437 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VXK6-1", "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "eIF5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLFDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLLKVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGTNQASQTEAEISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAKGMTISDDYDKTEKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKNRPLLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEEDNYVSSAGQRGGQRVVQRGIPRAVAGDEDDEDDVNIDDI", "length": 464 }, "evidence": [ { "id": "F1N0F7", "url": "https://omabrowser.org/oma/group/F1N0F7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "eukaryotic initiation factor eIF2 binding", "id": "GO:0071074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071074", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "GDP-dissociation inhibitor activity", "id": "GO:0005092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005092", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of translational initiation", "id": "GO:0006446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006446", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" }, { "name": "ribosome assembly", "id": "GO:0042255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042255", "evidence": [ { "database": "UniProtKB", "id": "F1N0F7", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0F7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 429, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0F7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0F7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0F7" }, { "id": "PS51363", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51363" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "W2", "eco_id": "ECO_0000259", "start_pos": 231, "end_pos": 390, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 6, "end_pos": 8 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0G5-1", "uniprot_ac": "F1N0G5", "uniprot_id": "F1N0G5_BOVIN", "mass": { "chemical_mass": 38524.0, "monoisotopic_mass": 38524.0 }, "refseq": { "ac": "XP_059745883", "name": "trace amine-associated receptor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745883" }, "gene_names": [ { "name": "TAAR1", "type": "recommended", "evidence": [ { "id": "F1N0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ] }, { "name": "TAAR1", "type": "synonym", "evidence": [ { "id": "XP_059745883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745883" } ] } ], "protein_names": [ { "name": "Trace amine-associated receptor 1", "type": "recommended", "evidence": [ { "id": "F1N0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0G5/entry#names_and_taxonomy" } ] }, { "name": "trace amine-associated receptor 1", "type": "synonym", "evidence": [ { "id": "XP_059745883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745883" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAAR1", "url": "https://www.uniprot.org/uniprotkb/F1N0G5", "locus": { "chromosome": "9", "start_pos": 70806940, "end_pos": 70807950, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037718", "url": "https://www.ensembl.org/id/ENSBTAG00000037718" } ] } } ], "crossref": [ { "id": "F1N0G5", "url": "https://alphafold.ebi.ac.uk/entry/F1N0G5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037718", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037718", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15314", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15314", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "104969593", "url": "https://www.ncbi.nlm.nih.gov/gene/104969593", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104969593", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104969593", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MQLCCES", "url": "https://omabrowser.org/oma/group/MQLCCES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0G5", "url": "https://www.orthodb.org/?gene=F1N0G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24249:SF415", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24249:SF415", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059745883", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0G5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMSLCHNKINISCVKSSWSNDIRASLYSLMVLIILTTVVGNLLVIISISHFKQLHTLNNWLIQSMATVDFLLGCLVMPYSMVRSIEHHWSFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKTKINILVISLMIFISWSIPALFAFGMIFLELNFKGAEEMYYKHSHCIGSCSVFFSKTSGVLAFMTSFYIPGSIMLCIYCRIYFIAKGQARSIHDAKQKVQIGLEERNGISRSRGRKAAKTLGIVMGVFLTCWCPFFVCMVMDPFLDYTIPPTLNDALIWFGYLNSTFNPMIYAFFYPWFRRALKIILVGKIFQKDSSRSKLFSE", "length": 336, "header": "tr|F1N0G5-1|F1N0G5_BOVIN Isoform 1 of Trace amine-associated receptor 1 OS=Bos taurus OX=9913 GN=TAAR1 PE=3 SV=2 CANONICAL=F1N0G5-1" }, "isoforms": [ { "isoform_ac": "F1N0G5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0G5/entry", "sequence": { "sequence": "MMSLCHNKINISCVKSSWSNDIRASLYSLMVLIILTTVVGNLLVIISISHFKQLHTLNNWLIQSMATVDFLLGCLVMPYSMVRSIEHHWSFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKTKINILVISLMIFISWSIPALFAFGMIFLELNFKGAEEMYYKHSHCIGSCSVFFSKTSGVLAFMTSFYIPGSIMLCIYCRIYFIAKGQARSIHDAKQKVQIGLEERNGISRSRGRKAAKTLGIVMGVFLTCWCPFFVCMVMDPFLDYTIPPTLNDALIWFGYLNSTFNPMIYAFFYPWFRRALKIILVGKIFQKDSSRSKLFSE", "length": 336, "header": "tr|F1N0G5-1|F1N0G5_BOVIN Isoform 1 of Trace amine-associated receptor 1 OS=Bos taurus OX=9913 GN=TAAR1 PE=3 SV=2 CANONICAL=F1N0G5-1" }, "locus": { "chromosome": "9", "start_pos": 70807950, "end_pos": 70806943, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054907.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054907.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047542.2", "url": "https://www.ensembl.org/id/ENSBTAP00000047542.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104969593", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104969593", "resource": "KEGG Pathway" }, { "id": "R-BTA-375280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375280", "resource": "Reactome", "description": "Amine ligand-binding receptors" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LF32-1", "protein_name": "Trace amine-associated receptor 1", "gene_name": "Taar1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRRCHDINISHMNSNWSRDVSASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMATVDFLLGCLVMPYSMVRTVEHCWYFGEIFCKVHTSTDIMLSSASIFHLSFISIDRYYAVFDPLRYKAKMSILTILVMILISWSVPAIFAFGMIFLELNIRGVEELYHKQAGCLGGCSTFFSKVSGVLVFMTVFYIPGSVMLFVYYRIYFIAKGQARSIHGTSLQIGLEEKHGMPQSKETKAAKTLGIVMGVFLICWSPFFFCMVLDPFLGYAIPLTLIDALSWFGYLNSAFNPVVYAFFYPWFRRALKMIVFGKIFQRDSSRSKLFF", "length": 331 }, "evidence": [ { "id": "F1N0G5", "url": "https://omabrowser.org/oma/group/F1N0G5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XCM3-1", "protein_name": "Trace amine-associated receptor 1", "gene_name": "TAAR1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQLCCESVNGSCVKSNWSNSIRISMYIFMVCVILTTVIGNLMVIISISHFKQLHTPTNFLIISMATADFLLGFLIMPCSMVRSVEHCWYFGDFFCKIHTSTDIMLSTTSIFHLSFISIDRYYAVCDPLRYKSKINAFVILVMILVSWTVPAAFAFGMIFLELNLLGAKEIYNHTHCAGGCLVFFNETSGVVTSVVSFYIPGLVMLFIYRKIYSIAKRQARSIDAVSKKKKRYETKHISFCRERKAAKTLCIVMGVFLICWSPFFFFTATDPFMNYAAPPVLTDTLVWFGYLNSAFNPIVYAFFYMWFRRALKTILFGNIFQQDSSRTQLFLE", "length": 332 }, "evidence": [ { "id": "F1N0G5", "url": "https://omabrowser.org/oma/group/F1N0G5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q923Y8-1", "protein_name": "Trace amine-associated receptor 1", "gene_name": "Taar1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL", "length": 332 }, "evidence": [ { "id": "F1N0G5", "url": "https://omabrowser.org/oma/group/F1N0G5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q923Y9-1", "protein_name": "Trace amine-associated receptor 1", "gene_name": "Taar1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL", "length": 332 }, "evidence": [ { "id": "F1N0G5", "url": "https://omabrowser.org/oma/group/F1N0G5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96RJ0-1", "protein_name": "Trace amine-associated receptor 1", "gene_name": "TAAR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS", "length": 339 }, "evidence": [ { "id": "F1N0G5", "url": "https://omabrowser.org/oma/group/F1N0G5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" }, { "name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "id": "GO:0007193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007193", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "trace-amine receptor activity", "id": "GO:0001594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001594", "evidence": [ { "database": "UniProtKB", "id": "F1N0G5", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0G5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 336, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0G5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0G5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0G5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 304, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 296, "end_pos": 298 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0I3-1", "uniprot_ac": "F1N0I3", "uniprot_id": "F1N0I3_BOVIN", "mass": { "chemical_mass": 239546.0, "monoisotopic_mass": 239546.0 }, "refseq": {}, "gene_names": [ { "name": "F5", "type": "recommended", "evidence": [ { "id": "F1N0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ] } ], "protein_names": [ { "name": "Coagulation factor V", "type": "recommended", "evidence": [ { "id": "F1N0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0I3/entry#names_and_taxonomy" } ] }, { "name": "Activated protein C cofactor", "type": "synonym", "evidence": [ { "id": "F1N0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0I3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "F5", "url": "https://www.uniprot.org/uniprotkb/F1N0I3", "locus": { "chromosome": "16", "start_pos": 37158072, "end_pos": 37238409, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017722", "url": "https://www.ensembl.org/id/ENSBTAG00000017722" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017722", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017722", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14451", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14451", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14453", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14453", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14455", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14455", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011707", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011707", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YQSNIMS", "url": "https://omabrowser.org/oma/group/YQSNIMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46806", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46806", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46806:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46806:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5694530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769735", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769735", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769739", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769743", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769743", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0I3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLACPGFWVLVVLGSSWAGWGNLGAEAAKLRQFYVAAQSIRWNYRPESTHLSSKPFETSFKKIVYREYEAYFQKEKPQSRTSGLLGPTLYAEVGDIMKVHFKNKAHKPLSIHAQGIKYSKFSEGASYSDHTLPMEKMDDAVAPGQEYTYEWIISEDSGPTHDDPPCLTHIYYSYVNLVEDFNSGLIGPLLICKKGTLTEDGTQKMFEKQHVLMFAVFDESKSWNQTSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFTIHFNGQVLEQNHHKISAITLVSATSTTANMTVSPEGRWTIASLIPRHFQAGMQAYIDIKNCAKKTRNPKKLTRDQRRHIKRWEYFIAAEEVIWDYAPIIPANMDKKYRSLHLDNFSNRIGKHYKKVVYKQYQDDSFTKRLEDPSSEGDGILGPIIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYDNEVNSSSTSGSNTMIRAVRPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDLASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPENSKSEASFYFTLPAINGYVPESIPILGFCFDDTVQWHFCSVGTQNDIFTIHFTGHSFIYGKRHEDTLTLFPMQGESVTVTMDNVGTWMLTTMNSNPRSKKLRLRFRDAKCIRNDDDDSYEIIYEPSGSTAMTTKKIHDSSEIEDENDADSDYQDELALILGLRSFRNSSLNQEKDELNLTALALEKDSEFIPPSANRSLGSNSSSPSHVSRLIANNFAESLKTLLHLEAPAAGSPLEHAGLDKNSALNPPMAEHSSPYSEDPREDHPLSDVTGISLLPFGTGFKNRKPAKHQRFQVGRGQAAKHKFSQTRFPAHKTRTRLSKDNSSSSRMGPWEDIPSDLLLLQQKDPYKILNGEWHLVSEKGSYEIIQDANENKTVNKLPNSPQNDSRTWGENIPFKNSHGKQSGHPTFLVTRRKPLQDRQDRRNRLKEGLPLIRTRRKKKEEKPAYHVPLSPRSFHPLRGEVNASFSDRRHNHSLLLHASNETSLSIDLNQTFPSMNLSLAASLPDHDQTSPNDTTSQTSSPPDLYPTVSPEEHYQIFPIQDSDPTHSTTAPSNRSPDPTHSTTAPSNRSPPTQPSQIPNYDLRNRAIPTDVSQIFPSLELEVWQTATSLDLSQPSISPDLGQMALSPDPGQESLSPDLGQTSLSPDLSQESLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQESLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQESLSPDLGQTALSPDLSLESLSPDLSQLDLKQTSPPLDLNQTSHTSESSQSLPLPEFGQTFPNADIGQMPSPPPDSTLNNTFKPEEFNPLVVVGLSRDDGDYIEIIPRQKEESSEEDYGEFEFVAYNDPYQTDLRTDINSSRNPDNIAAWYLRSNTGNRKYYYIAAEEISWDYSKFVQSDDVDYVPEDTVYKKVVFRKYLDSTFTKLDPQGEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAIQPNKTYTYVWHATTRSGPENPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLDKETNMPVDMREFVLLFMVFDEKKSWYYDKKPTRSWRRASSEVKNSHEFHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKASKPGWWLLDTEVGEIQRAGMQTPFLIVDRECKMPMGLSTSLIADSQIQASEFWGYWEPKLARLNNGGSYNAWIAEKLSTEFNPEPWIQVDMQKEVLLTGIQTQGAKHYLKPYYTTEFCVAYSLDRKNWRIFKGNSTRNVMYFGGNSDASTIKENQIDPPVVARYIRISPTGSYNKPALRLELQGCEVNGCSTPLGMESGKIENKQITASSFKKSWWGNYWEPFLARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTIHYSDQGTDWKPYREKSSMVDKIFEGNNNVRGHVKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDMY", "length": 2121, "header": "tr|F1N0I3-1|F1N0I3_BOVIN Isoform 1 of Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=3 SV=3 CANONICAL=F1N0I3-1" }, "isoforms": [ { "isoform_ac": "F1N0I3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0I3/entry", "sequence": { "sequence": "MFLACPGFWVLVVLGSSWAGWGNLGAEAAKLRQFYVAAQSIRWNYRPESTHLSSKPFETSFKKIVYREYEAYFQKEKPQSRTSGLLGPTLYAEVGDIMKVHFKNKAHKPLSIHAQGIKYSKFSEGASYSDHTLPMEKMDDAVAPGQEYTYEWIISEDSGPTHDDPPCLTHIYYSYVNLVEDFNSGLIGPLLICKKGTLTEDGTQKMFEKQHVLMFAVFDESKSWNQTSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFTIHFNGQVLEQNHHKISAITLVSATSTTANMTVSPEGRWTIASLIPRHFQAGMQAYIDIKNCAKKTRNPKKLTRDQRRHIKRWEYFIAAEEVIWDYAPIIPANMDKKYRSLHLDNFSNRIGKHYKKVVYKQYQDDSFTKRLEDPSSEGDGILGPIIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYDNEVNSSSTSGSNTMIRAVRPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDLASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPENSKSEASFYFTLPAINGYVPESIPILGFCFDDTVQWHFCSVGTQNDIFTIHFTGHSFIYGKRHEDTLTLFPMQGESVTVTMDNVGTWMLTTMNSNPRSKKLRLRFRDAKCIRNDDDDSYEIIYEPSGSTAMTTKKIHDSSEIEDENDADSDYQDELALILGLRSFRNSSLNQEKDELNLTALALEKDSEFIPPSANRSLGSNSSSPSHVSRLIANNFAESLKTLLHLEAPAAGSPLEHAGLDKNSALNPPMAEHSSPYSEDPREDHPLSDVTGISLLPFGTGFKNRKPAKHQRFQVGRGQAAKHKFSQTRFPAHKTRTRLSKDNSSSSRMGPWEDIPSDLLLLQQKDPYKILNGEWHLVSEKGSYEIIQDANENKTVNKLPNSPQNDSRTWGENIPFKNSHGKQSGHPTFLVTRRKPLQDRQDRRNRLKEGLPLIRTRRKKKEEKPAYHVPLSPRSFHPLRGEVNASFSDRRHNHSLLLHASNETSLSIDLNQTFPSMNLSLAASLPDHDQTSPNDTTSQTSSPPDLYPTVSPEEHYQIFPIQDSDPTHSTTAPSNRSPDPTHSTTAPSNRSPPTQPSQIPNYDLRNRAIPTDVSQIFPSLELEVWQTATSLDLSQPSISPDLGQMALSPDPGQESLSPDLGQTSLSPDLSQESLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQESLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQESLSPDLGQTALSPDLSLESLSPDLSQLDLKQTSPPLDLNQTSHTSESSQSLPLPEFGQTFPNADIGQMPSPPPDSTLNNTFKPEEFNPLVVVGLSRDDGDYIEIIPRQKEESSEEDYGEFEFVAYNDPYQTDLRTDINSSRNPDNIAAWYLRSNTGNRKYYYIAAEEISWDYSKFVQSDDVDYVPEDTVYKKVVFRKYLDSTFTKLDPQGEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAIQPNKTYTYVWHATTRSGPENPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLDKETNMPVDMREFVLLFMVFDEKKSWYYDKKPTRSWRRASSEVKNSHEFHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKASKPGWWLLDTEVGEIQRAGMQTPFLIVDRECKMPMGLSTSLIADSQIQASEFWGYWEPKLARLNNGGSYNAWIAEKLSTEFNPEPWIQVDMQKEVLLTGIQTQGAKHYLKPYYTTEFCVAYSLDRKNWRIFKGNSTRNVMYFGGNSDASTIKENQIDPPVVARYIRISPTGSYNKPALRLELQGCEVNGCSTPLGMESGKIENKQITASSFKKSWWGNYWEPFLARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTIHYSDQGTDWKPYREKSSMVDKIFEGNNNVRGHVKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDMY", "length": 2121, "header": "tr|F1N0I3-1|F1N0I3_BOVIN Isoform 1 of Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=3 SV=3 CANONICAL=F1N0I3-1" }, "locus": { "chromosome": "16", "start_pos": 37238306, "end_pos": 37159076, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023573.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023573.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023573.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023573.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-5694530", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694530", "resource": "Reactome", "description": "Cargo concentration in the ER" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" }, { "id": "R-BTA-9769735", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769735", "resource": "Reactome", "description": "Initiation of coagulation cascade" }, { "id": "R-BTA-9769739", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "resource": "Reactome", "description": "Regulation of clotting cascade" }, { "id": "R-BTA-9769743", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769743", "resource": "Reactome", "description": "Amplification and propagation of coagulation cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K3W2-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLATGGRDLTKPLPTLGIEGKGGRVIQPPLGTGTLTAPNSFLVLQGVRTARSRDRALSTVSRGSARGRTRAMFLVCPRFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWNYHPESADPSLNSIPSFKKIVYREYEPYFKKEKPRSSNSGLLGPTLYAEVGDTIKVHFRNKADKPLSIHPQGIRYSKFSEGASYLDHTSPAERKDDAVAAGEEYTYEWFIGEDSGPTPDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKEGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQSPALMYTVNGFVNRTMPDVTVCAYDHVSWHLIGMSSGPELFSIHFNGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGKWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSSKTLTREQRRHMKRWEYFIAAEEVIWNYAPVIPANMDKLYKSLHLDNFSNQIGKHYKKVIYREYKDETFTKRIENQSSRQSGILGPIIKAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDGVNSSSTSGSHTMIKPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIGLLLICKSRSLDQRGIQRVADMEQEVVFAMFDENKSWYIEDNINKFCENPDEVKRDDPKFYESNIMNTINGYVPESISTLGFCFDDAVQWHFCSVGTHDDILTVHFTGHSFIYGRRHEDTLTLFPMSGESVTVVMDNIGTWMLTTMSSNPRRRNLRLRFRDVKCNRNDDDDEDSYEIYQPLEPTSMTTRKIHDSVENDFGIENEDDDYQYELASTLGIRSFRKSLLNPKEDEFNLTALALENSSEFISLSTDGVVDSKSSRNLSKITNNNLNDSQRTLSGSGATIAGILLGNLTGLGKNSVLNPSTEYHSSSYYENDMEDPQSNITVVYLLPLGAKGSGSREQTKPKTIKTGRPHRMKHRFSWMKAPAGKTGRHSNPKNTSSRMKSEEDIPSDLLLLKQKVASKLLNRQWHMASEKGSYEIIPANGENTDIDKLTNSPQNQNISTPWGASTSRINTTGKPSNLPTFSRFRHKSPHVRQEEESGDFKKRQLFIRTRKKKKNRKFALHSPLSPRGFYHPRREDHPPLLDRRLLNHSLLLHKSNETALSTDLNQTSPPVSTDRSLPDYNQNPSNDTEQMSSSLDLFQSVPPEEHSPTFPTQDPNQTHSTTDPSYRSSPPEPSQGIDYDLSHEFYSDDISQTSFFPDQSQKSPLTSDDGQAIPSSDLNLFTISPELDQTIIYPDLDQLFLSPDDIQKTSSQDLGQVTLSPDENQETSSQDLGQVTLSPNENQETSSQDLGQVTLSPDDIQETSSQDLGQVTLSPDENQETSSPDLGQVPLTPDDNQKTSPDLGQVLLSLDDKQKTYFLDPGQVPISSDQSWETSSTDLSLLTLSPKFGQTVISPDLDKMPLSSDNSQVTLSPDLSLLTLSPDFNEIILSPDIDQVTLSPDLIQTSPALNHRHKTSSADPGQASYPPDSGQSSPLPELNQTLPHPDLIHMQPPLLSPTPNDTSLSKTFNPLVVVGLSRVDGDDVEMIPSEELESIDEDYPEDDYVTYNDPYKTDTRANVNSSRNPDTIAAWYLRSFGGNKKFYYIAAEEISWDYSKFAPSEMDNEETDNTPKDTTYKKVVFRKYLDSTFTSRDPQGEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKNYEDDSPKWFQEDDAVQPNSSYTYVWHATERAGPENPGSACRAWVYYSAVDVERDIHSGLIGPLLICRKGTLDRASNLPLDMREFVLLFMVFDEKKSWYYEKSKGSWRIESPEAKNSHEFYAINGMIYNLPGLRMYEQEWVRLYLLNMGGPQDIHVVHFHGQILLDNRTKQHHLGVWPLLPGSFKTLEMKASKPGWWLLDTAVGENQIAGMQTPFLIIDKECKMPMGLSTGAISDSQIKASEYLTYWEPRLARLNNGGSYNAWSIEKSALDFPIKPWIQVDMEKEVVVTGIQTQGAKYYLKSCFTTEFQVAYSSDRTNWQIFRGNSMKSVMSFAGNSDASTIKENRFDPPIVARYIRIHPTKSYNRPTLRLELLGCEVNGCSTPLGLEDGRIQNKQITASSFKKSWWGSYWEPSLARLNAQGRVNAWQAKANNNKQWLQIDLLKIKKVTAIVTQGCKSLSSEMYVKSYSILYSDQGVSWKPYRQKSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDIY", "length": 2259 }, "evidence": [ { "id": "F1N0I3", "url": "https://omabrowser.org/oma/group/F1N0I3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XX93-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTLHCVHLFLLLLLSSWWPDSEKHVVGAVKVREHYIAAQFTVWTYKPESEEKSRLTHLDPVFKKISYREYEVDFKKEKPADKSTGLLGPTLRAEVGDTLVVHFKNMADKPISIHPQGLVYNKKAEGSLYADRTSRVEKQDDAVLPGQVYTYVWDITEEVGPREADLPCLTYAYYSHENMVMDFNSGLIGALLICKKGSLNEDGSQKLFDKEYILMFGVFDENKSWQRSASLKYTINGYADGTLPDLEACMYDNISWHLIGMSSKPEIFSVHINGQVMEERHHRISTVNLVGGASTTVNMTVSEEGRWLISSLVQKHLKAKMHGYLTVRDCGDREVKKSRLSLKERRMIKNWEYFIAAEEVVWDYAPTIPDSLDKRYKAQHLDNYSNLIGKKYKKAIFRQYTDGSFTKRLENPRPKETGILGPIIRAQINDKVKIVFKNKASRPYSMYFHGVTLSKNAEGADYPQDPTGNATQSKGIQPGKTYTYEWQIAKTDQPTAQDAQCITRLYHSAVDIERDIASGLVGPLLICKSEALSQKGVQKKADGEQHAMFAVFDENKSWYIEDNIKDYCSNPASVRRDDPKFYNSNIMHTINGYVSDRNEILGFCQDNVVQWHFSSVGTQDEVVSIRLSGHAFLYRGKYEDVLNLFPMSGESVTVEMDNIGTWLLASWGATEMSYGMRLRFRDVRCDYEDDNLFDVVDFTNTKTDKKALSTSVEEDVEEEAEDDDSEYQDLLASFYSIRSLRNTGETEETQNLTAMAWGQDGDIDTASSKLAIDSDLTVTNGSKLTEFLETRIAPPLQVETETFQSNYTSVTAEEYLLLASASDGKPDLVFENRSQSDYAVDHSNMSGGEHLLSNGEAHVKDAEEPLTDRKDSNFFTEEHQEESAGKRNNSINSKRKKRSPLAVKFYAVQKMKALLDHVRNKNGSFSDKTNAPNSMQHTENTSSTATVGAGQHPSDYDDDLEEEETKEGNAMHAGNLTLELEATVEENESNTSRLSQLELSKDKQSDSFSLDQTLGNIRPNSSPALVKNFLEASLPRAVKYSSKMTDEEWNLVSAKGIQRLEANLDKSVSGKLNYGGRNGTIFLNKKHKKKDGEFSHLMGEKHKGNHMRSPLKRKEGNKNDTLSISGTFVKIRRKKKEYPKTTQFLNPRSKKPQKFAKPTEEFGRTLFPGGANHESLPCCNTTESPSKSSHRELPGYTQQLKPSIVIGLPHENGNYEYTSGEYYTEDTSGDEYEYYYVSFDDPYMTDPKLNVNEQRNPDNIAEHYLRSRGNERRYYIAAKEVCWNYAGLKKSTMMYDKICKDGSTKKVIFQRYTDSTFTTVQDEGEYEEHLGILGPVIRAEVNDVILVHFKNLASRPYSLHAHGLFYEKSSEGSIYDDESSDWFKEDDKVQPNSSYIYVWYANRRSGPLQPGAACRSWVYYSDVNLEKDTHSGLIGPILICEKGTFSASDNNRTNTRDFFLLFMVFDEEKSWYFDKRSRKPCTEKTQEMQQCHKFYAINGITNNLQGLRMYEGELVRWHLLNMGVPKDIHVVHFHGQTFIEQLEAKYQLGTYTLLPGSFQTVEMKPQRPGWWLLDTEVGEYQQAGMQASYLVLEKGCRIPMGMASGVILDSQINASHHIDYWEPKLARLNNSGTYNAWSTTMTDDLPWIQVDFQRQVLLTGIQTQGAKHFLKSFYVQKFFIVYSTDKRKWNTFRGDSSPAEKIFEGNSDAYGIKENIIDPPIIARYIRVYPKQAYNEPTLRMELLGCEVDACSLPLGMENGEIKNTQITASSVKTSWFSTWEPSLARINQKGKINAWRAKSNNNQQWLQIDLLTIKKITAIATQGVKSVTTENFVKTYVILYSNQGSEWKSYTEDSSSVAKVFSGNEDSRGHVKHFFNPPILSRFIRIVPKTWYNGIALRVELFGCDFGGDLTAKRTEKSGSS", "length": 1922 }, "evidence": [ { "id": "F1N0I3", "url": "https://omabrowser.org/oma/group/F1N0I3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RPW2-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFPALPCPWVLVVLGTSWAAWGNLGTEAARVRQFYVAAQSISWNYHPEPTHPSSSPFATSFKKIVYREYEAYFQKEKPPSRMSGLLGPTLYAEVGDIMKVHFRNKADKPLSIHPQGIKYSKFAEGASYPDHTFLVEKMDDAVAPGQEYTYEWNISEDSGPTHNDPPCLTHIYYSYENLIQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQYVLMFAVFDESKSWNQSSSLMYTVNGYVNGTMPDITVCAYDHISWHLIGMSSGPELFSIHFSGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWPISSLIPKHFQAGMQAYIDIKNCAKKTRKPKKLTRDQRRHIKRWEYFIAAEEVIWDYAPIIPANMDKKYRSLHLDNFSNQIGKHYKKVVYKQYQDESFTKRLENPNNKEDGILGPVIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYEDDVNSSSTSDNNTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIGLLLICKSRSLDKRGIQRTADIEQKAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMSTINGYVPESIPTLGFCFDDTVQWHFCSVGNQNNILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTTMNSNPRNKKLQLKFRDVKCIRDDDEDSYEIIYEPSSSTTLTTRKMHDSSENKEEENDDEYDYQDLLASVLGIRSFRNSSLYQEDDEFNLTALALENNSEFIPPSTDRAVDSNSSSPGNISRAPANTFTEPQKILPHPEATKAGSPRRHTGLVKNLVLNRRRTQHSDPYSEDPIENPLQSVITGISLLPFGTEGFRNREHPKHKRFKAGRDQAAKHRFSQMEFPAHKTGRHISQDNSSSSSIGPLEDLSSDLLLLERKDPSTINGKWHLVSEKGSYEIVQDADEDMAVNKLPNNPQNASRSWGENIPFTNKHGKQRGHPIFVTRHKLLQERQDEGNSILKKGRFFIRTRRKKKERKPVHHVPLSPRSFNPLRGEANTPFSDRRQNHSLLLHESNETFPPTDLNQTFPSMNLSLIASHPDHNQNLPNDTHQTSSPLDLYQTVTPDEPYQTAPIQDLDPTHSTAVPSHQSSLPEPIQMHDYDLRNKASPTDVSEMFFSLKLKAGHRTTSPDLNQPSFSPELSQTTLSPDPGHVTLSQDLSQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLSPDLSQTTLSPDLSHTTLSPDLGHATLSPDLSHTTLSPDLGHATLSPDLSHTTLSPDLGHTTLSPDLGHTTLSPDFSQTTLSPDLGHTTLSSDLSHTTLSPDLSHTTLSPDLSHTTLSPDLGHTTLSPDFSQTTLSPDLGHMTLSPDLSHTTLSPDLGHTTLSPDFSHTTLSPDLGHMTLSPDLDQTTLSLDFGQTTLSPDLSHMTLSSELSHETVSPDLSHVTLSPDLREIPFSPDLRQATLSPDINETTLSPDLRQTSPHLDPDKTSYISESSQSVTLPEFGQTSPFPDLGQRPSPPSHSTLNNTFIPREFNPMVVVGLSRDDGDYVEIIPRQQEENSEEDYVKIDYVEYDDPYQTDVRTDINSSRNPDNIAAWYLRSNNGNRRNYYIAAEELSWDYSKFTQREDIDDVPEHTIYKKVVFRKYLDSTFTKLDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLHKENNMPVDMREFVLLFMVFDEKKSWYYEKKFTRSWRLTSSEVKNSHKFHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKTSKAGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGLIADSQIKASEFWGHWQPKLARLNNGGSYNAWITDKFSGESNSKPWIQVDMQREVVFTGIQTQGAKYYLKSYYTTEFNVAYSSDQRNWRIFKGNSTKNVMYFNGNSDASTITENQFDPPVVARYIRISPTESYNKPALRLELQGCEVNGCSTPLGMESGNIKNEQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAITTQGCKSLSSEMYVKRYTIQYSDRGVEWKSYREKSSMVDKIFEGNNNIKGHVKNFFNPPIISRFIRIIPKMWNQSIALRLELFGCDIY", "length": 2258 }, "evidence": [ { "id": "F1N0I3", "url": "https://omabrowser.org/oma/group/F1N0I3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O88783-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLVCPCFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWNYHPEPTDPSLNSIPSFKKIVYREYEQYFKKEKPRSSNSGLLGPTLYAEVGDVIKVHFRNKADKPLSIHPQGIKYSKFSEGASYADHTFPAERKDDAVAPGEEYTYEWIVSEDSGPTPDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSRSQSPSLMYTINGFVNKTMPDITVCAHDHVSWHLIGMSSGPELFSIHFNGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGRWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSPKTLTREQRRYMKRWEYFIAAEEVIWNYAPVIPANMDKIYRSQHLDNFSNQIGKHYKKVIYRQYEEETFTKRTDNPSIKQSGILGPVIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDGINSSSTSGSHTTIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIGLLLICKSRSLDQRGVQRVADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESISTLGFCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRRHEDTLTLFPMRGESVTVTMDNVGTWMLTTMNSNPKRRNLRLRFRDVKCNRDYDNEDSYEIYEPPAPTSMTTRRIHDSLENEFGIDNEDDDYQYLLASSLGIRSFKNSSLNPEENEFNLTALALENSSEFISPSTDRVVDSNSSRILSKIINNNLKDFQRTLPGSGATVAGTLLRNLIGLDENFVLNSSTEHRSSSYHENDMENPQSNITMVYLLPLGPKGSGNREQDKPKTIKTGRPHMMKHRFSWMKAPAGKTGRHSNPKNSYSGMKSEEDIPSELIPLKQKITSKFLNRRWRVASEKGSYEIIAANGEDTDVDKLTNSPQNQNITVPRGESTSHTNTTRKPSDLPTFSGVGHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSPRGFDPLRGHNHSPFPDRRLLNHSLLLHKSNETALSPDLNQTSPSMSTDRSLPDYNQYSKNDTEQMSSSLDLYQSVPAEEHSPTFPAQDPDQTHSTTDPSYRSSPPELSQGLDYDLSHDFYPDDIGLTSFFPDQSQKSSFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQLLLSPEDNQKTSSPDLGQVPLSPDDNQKTSSPDLGQVSLSPDDNQKTSSPDLGQVPLSLDDNQKTTSPDLGQVPLSPDDNQMITSPDLGQVPLSSDNQKTSSPDLGQVPLFPEDNQNYFLDLSQVPLSSDQNQETSSTDLLTLSPDFGQTVLSPDLDQLPLPSDNSQVTVSPDLSLLTLSPDFNEIILAPDLGQVTLSPDLIQTNPALNHGHKASSADPDQASYPPDSGQASSLPELNRTLPHPDLTHIPPPSPSPTLNNTSLSRKFNPLVVVGLSRVDGDDVEIVPSEEPERIDEDYAEDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYLRGHGGHKKFYYIAAEEITWNYAEFAQSEMDHEDTGHTPKDTTYKKVVFRKYLDSTFTSRDPRAEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDESPEWFQEDDAVQPNSSYTYVWHATKRSGPENPGSACRAWAYYSAVNVERDIHSGLIGPLLICRKGTLHMERNLPMDMREFVLLFMVFDEKKSWYYEKSKGSRRIESPEEKNAHKFYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLDNRTKQHQLGVWPLLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDSQIKASEYLTYWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAKHYLKSCFTTEFQVAYSSDQTNWQIFRGKSGKSVMYFTGNSDGSTIKENRLDPPIVARYIRIHPTKSYNRPTLRLELQGCEVNGCSTPLGLEDGRIQDKQITASSFKKSWWGDYWEPSLARLNAQGRVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYVKSYSIQYSDQGVAWKPYRQKSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDIY", "length": 2183 }, "evidence": [ { "id": "F1N0I3", "url": "https://omabrowser.org/oma/group/F1N0I3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY", "length": 2224 }, "evidence": [ { "id": "F1N0I3", "url": "https://omabrowser.org/oma/group/F1N0I3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ], "pmid": "" }, { "name": "platelet alpha granule", "id": "GO:0031091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031091", "evidence": [ { "database": "UniProtKB", "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ], "pmid": "" }, { "name": "blood circulation", "id": "GO:0008015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008015", "evidence": [ { "database": "UniProtKB", "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "F1N0I3", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1035, "end_pos": 1037, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1044, "end_pos": 1046, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1053, "end_pos": 1055, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1062, "end_pos": 1064, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1069, "end_pos": 1071, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1085, "end_pos": 1087, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1126, "end_pos": 1128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1140, "end_pos": 1142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1361, "end_pos": 1363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1460, "end_pos": 1462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1600, "end_pos": 1602, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1749, "end_pos": 1751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1907, "end_pos": 1909, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2106, "end_pos": 2108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 737, "end_pos": 739, "annotation": "n_glycosylation_sequon" }, { "start_pos": 748, "end_pos": 750, "annotation": "n_glycosylation_sequon" }, { "start_pos": 766, "end_pos": 768, "annotation": "n_glycosylation_sequon" }, { "start_pos": 772, "end_pos": 774, "annotation": "n_glycosylation_sequon" }, { "start_pos": 894, "end_pos": 896, "annotation": "n_glycosylation_sequon" }, { "start_pos": 944, "end_pos": 946, "annotation": "n_glycosylation_sequon" }, { "start_pos": 956, "end_pos": 958, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0I3" }, { "id": "PS50022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F5/8 type C", "eco_id": "ECO_0000259", "start_pos": 1804, "end_pos": 1958, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1035, "end_pos": 1037 }, { "start_pos": 1044, "end_pos": 1046 }, { "start_pos": 1053, "end_pos": 1055 }, { "start_pos": 1062, "end_pos": 1064 }, { "start_pos": 1069, "end_pos": 1071 }, { "start_pos": 1085, "end_pos": 1087 }, { "start_pos": 1126, "end_pos": 1128 }, { "start_pos": 1140, "end_pos": 1142 }, { "start_pos": 1361, "end_pos": 1363 }, { "start_pos": 1400, "end_pos": 1402 }, { "start_pos": 1460, "end_pos": 1462 }, { "start_pos": 1600, "end_pos": 1602 }, { "start_pos": 1749, "end_pos": 1751 }, { "start_pos": 1907, "end_pos": 1909 }, { "start_pos": 2106, "end_pos": 2108 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 239, "end_pos": 241 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 553, "end_pos": 555 }, { "start_pos": 737, "end_pos": 739 }, { "start_pos": 748, "end_pos": 750 }, { "start_pos": 766, "end_pos": 768 }, { "start_pos": 772, "end_pos": 774 }, { "start_pos": 894, "end_pos": 896 }, { "start_pos": 944, "end_pos": 946 }, { "start_pos": 956, "end_pos": 958 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0J4-1", "uniprot_ac": "F1N0J4", "uniprot_id": "F1N0J4_BOVIN", "mass": { "chemical_mass": 34075.0, "monoisotopic_mass": 34075.0 }, "refseq": { "ac": "NP_001377367", "name": "olfactory receptor family 1 subfamily O member 9", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377367" }, "gene_names": [ { "name": "OR1O9", "type": "recommended", "evidence": [ { "id": "F1N0J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ] }, { "name": "OR1O8", "type": "synonym", "evidence": [ { "id": "F1N0J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ] }, { "name": "OR1O9", "type": "synonym", "evidence": [ { "id": "NP_001377367", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377367" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N0J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0J4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 1 subfamily O member 9", "type": "synonym", "evidence": [ { "id": "NP_001377367", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377367" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377367" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1O9", "url": "https://www.uniprot.org/uniprotkb/F1N0J4", "locus": { "chromosome": "23", "start_pos": 29237952, "end_pos": 29238881, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061157", "url": "https://www.ensembl.org/id/ENSBTAG00000061157" } ] } } ], "crossref": [ { "id": "F1N0J4", "url": "https://alphafold.ebi.ac.uk/entry/F1N0J4", "database": "AlphaFoldDB", "categories": [] }, { "id": "785779", "url": "https://www.ncbi.nlm.nih.gov/gene/785779", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785779", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785779", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377367", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0J4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNCSKNPDFVLLGLSNDPDKPQLLFGLFLALYLLSLLGNLLLLMVIGADIHLHTPMYFFLSQLSLVDLCFTTTTAPKMLETLWTSNGLISFSECLAQLYFFTVFADMDNLLLTAMAIDRYAAICHPLHYALLMTPCRCALLVGGSWGVAHSISLVHALLLSQLSFYSNQEIPHFFCDFGPLFRLSCSDTHLNEDLMMVLTGLLGISPLLCITSSYAHIFLAVARIPSAQGKKKALATCSSHLSMVILFYSSVFASYLKSPSASHASGELGAAVMYALVTPTLNPFIYSLRNKEVKRSLKRILGIESSWH", "length": 309, "header": "tr|F1N0J4-1|F1N0J4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1O9 PE=3 SV=3 CANONICAL=F1N0J4-1" }, "isoforms": [ { "isoform_ac": "F1N0J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0J4/entry", "sequence": { "sequence": "MNCSKNPDFVLLGLSNDPDKPQLLFGLFLALYLLSLLGNLLLLMVIGADIHLHTPMYFFLSQLSLVDLCFTTTTAPKMLETLWTSNGLISFSECLAQLYFFTVFADMDNLLLTAMAIDRYAAICHPLHYALLMTPCRCALLVGGSWGVAHSISLVHALLLSQLSFYSNQEIPHFFCDFGPLFRLSCSDTHLNEDLMMVLTGLLGISPLLCITSSYAHIFLAVARIPSAQGKKKALATCSSHLSMVILFYSSVFASYLKSPSASHASGELGAAVMYALVTPTLNPFIYSLRNKEVKRSLKRILGIESSWH", "length": 309, "header": "tr|F1N0J4-1|F1N0J4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1O9 PE=3 SV=3 CANONICAL=F1N0J4-1" }, "locus": { "chromosome": "23", "start_pos": 29238881, "end_pos": 29237955, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045150.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045150.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042565.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042565.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785779", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785779", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N0J4", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0J4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0J4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0J4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0J4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0L2-1", "uniprot_ac": "F1N0L2", "uniprot_id": "F1N0L2_BOVIN", "mass": { "chemical_mass": 309089.0, "monoisotopic_mass": 309089.0 }, "refseq": {}, "gene_names": [ { "name": "UBR5", "type": "recommended", "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase UBR5", "type": "recommended", "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.26", "type": "synonym", "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase, HECT domain-containing 1", "type": "synonym", "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2/entry#names_and_taxonomy" } ] }, { "name": "Hyperplastic discs protein homolog", "type": "synonym", "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBR5", "url": "https://www.uniprot.org/uniprotkb/F1N0L2", "locus": { "chromosome": "14", "start_pos": 62126918, "end_pos": 61988219, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021209", "url": "https://www.ensembl.org/id/ENSBTAG00000021209" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021209", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021209", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14423", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14423", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19675", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19675", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8V2", "url": "https://www.orthodb.org/?gene=A0A3Q1M8V2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0L2", "url": "https://www.orthodb.org/?gene=F1N0L2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46276", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46276", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46276:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46276:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00658", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00658", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11547", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11547", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M8V2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8V2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0L2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSSSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENNLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKSMDKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQSNSGSDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAIIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPAVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEVSSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAGNSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQSHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQTVVPEEAESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "length": 2798, "header": "tr|F1N0L2-1|F1N0L2_BOVIN Isoform 1 of E3 ubiquitin-protein ligase UBR5 OS=Bos taurus OX=9913 GN=UBR5 PE=3 SV=3 CANONICAL=F1N0L2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8V2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8V2/entry", "sequence": { "sequence": "MHVSAHRLTVLVRGVTLIHRRVANYERLTEEFAPCQYLLCVAGRVENNVRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSSSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENNLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKSMDKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQSNSGSDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAIIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPAVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEVSSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAGNSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQSHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQTVVPEEAESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVKVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "length": 2829, "header": "tr|A0A3Q1M8V2-1|A0A3Q1M8V2_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase UBR5 OS=Bos taurus OX=9913 GN=UBR5 PE=3 SV=2 CANONICAL=F1N0L2-1" }, "locus": { "chromosome": "14", "start_pos": 62124846, "end_pos": 61999648, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074994.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074994.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064890.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064890.2" } ] } }, { "isoform_ac": "F1N0L2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0L2/entry", "sequence": { "sequence": "MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSSSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENNLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKSMDKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQSNSGSDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAIIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPAVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEVSSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAGNSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQSHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQTVVPEEAESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV", "length": 2798, "header": "tr|F1N0L2-1|F1N0L2_BOVIN Isoform 1 of E3 ubiquitin-protein ligase UBR5 OS=Bos taurus OX=9913 GN=UBR5 PE=3 SV=3 CANONICAL=F1N0L2-1" }, "locus": { "chromosome": "14", "start_pos": 62124846, "end_pos": 61988418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028262.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028262.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028262.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028262.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1736, "start_aa": "Thr", "end_pos": 1736, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1736", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "ubiquitin-ubiquitin ligase activity", "id": "GO:0034450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034450", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "positive regulation of protein import into nucleus", "id": "GO:0042307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042307", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "nuclear protein quality control by the ubiquitin-proteasome system", "id": "GO:0071630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071630", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "cytoplasm protein quality control by the ubiquitin-proteasome system", "id": "GO:0071629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071629", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "protein K29-linked ubiquitination", "id": "GO:0035519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035519", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "progesterone receptor signaling pathway", "id": "GO:0050847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050847", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "heterochromatin boundary formation", "id": "GO:0033696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033696", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "DNA repair-dependent chromatin remodeling", "id": "GO:0140861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140861", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" }, { "name": "protein branched polyubiquitination", "id": "GO:0141198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141198", "evidence": [ { "database": "UniProtKB", "id": "F1N0L2", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1176, "end_pos": 1178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1629, "end_pos": 1631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1635, "end_pos": 1637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1669, "end_pos": 1671, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1700, "end_pos": 1702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1773, "end_pos": 1775, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1999, "end_pos": 2001, "annotation": "n_glycosylation_sequon" }, { "start_pos": 527, "end_pos": 529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 816, "end_pos": 818, "annotation": "n_glycosylation_sequon" }, { "start_pos": 857, "end_pos": 859, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 2503, "end_pos": 2798, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" }, { "id": "PS51309", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51309" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PABC", "eco_id": "ECO_0000259", "start_pos": 2377, "end_pos": 2454, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L2" }, { "id": "PS51157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBR-type", "eco_id": "ECO_0000259", "start_pos": 1177, "end_pos": 1245, "start_aa": "Asp", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.26", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.26" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1736 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1176, "end_pos": 1178 }, { "start_pos": 1629, "end_pos": 1631 }, { "start_pos": 1635, "end_pos": 1637 }, { "start_pos": 1669, "end_pos": 1671 }, { "start_pos": 1700, "end_pos": 1702 }, { "start_pos": 1773, "end_pos": 1775 }, { "start_pos": 1999, "end_pos": 2001 }, { "start_pos": 527, "end_pos": 529 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 816, "end_pos": 818 }, { "start_pos": 857, "end_pos": 859 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0N5-1", "uniprot_ac": "F1N0N5", "uniprot_id": "F1N0N5_BOVIN", "mass": { "chemical_mass": 38173.0, "monoisotopic_mass": 38173.0 }, "refseq": { "ac": "XP_010806343", "name": "8-oxo-dGDP phosphatase NUDT18 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806343" }, "gene_names": [ { "name": "NUDT18", "type": "recommended", "evidence": [ { "id": "F1N0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ] }, { "name": "NUDT18", "type": "synonym", "evidence": [ { "id": "XP_010806343", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806343" } ] } ], "protein_names": [ { "name": "8-oxo-dGDP phosphatase NUDT18 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010806343", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806343" } ] }, { "name": "Nudix hydrolase 18", "type": "synonym", "evidence": [ { "id": "F1N0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0N5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT18", "url": "https://www.uniprot.org/uniprotkb/F1N0N5", "locus": { "chromosome": "8", "start_pos": 69420124, "end_pos": 69423551, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003483", "url": "https://www.ensembl.org/id/ENSBTAG00000003483" } ] } } ], "crossref": [ { "id": "F1N0N5", "url": "https://alphafold.ebi.ac.uk/entry/F1N0N5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003483", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003483", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04671", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04671", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509535", "url": "https://www.ncbi.nlm.nih.gov/gene/509535", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N0N5", "url": "https://www.orthodb.org/?gene=F1N0N5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22769", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22769", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22769:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22769:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00293", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00293", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2393930", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2393930", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010806343", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806343", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0N5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0N5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEGLRGALTAVLGGRGLLVQNYDSGPAGEPPAPVRLRRNVCYVVLAVFLNEQDEVLLVQEAKKECRGSWYLPAGRMEPGETIVEALQREVKEEAGLQCEPLTLLSVEERGPSWIRFAFLTRPTGMAQQVAAWAEGSRHRSPGLYSGGILKTSKEADAESLQAGWYPRTSLPTPLRAQDILHLVDLAAQYRQRARHPLLLPQELPCSLVCQRLVATFTNVQTVWVLVGTVGTPHLPVTACGFTPMEQRGGIKMAVLRLLQECLSLHHLAVETQGLLGLQHLGKDLTDGICMNVLVTVAFRNPGLQNEPPKVRGENFFWWKVVEEDLQNQLLQRLRDSSVVPINR", "length": 345, "header": "tr|F1N0N5-1|F1N0N5_BOVIN Isoform 1 of Nudix hydrolase 18 OS=Bos taurus OX=9913 GN=NUDT18 PE=3 SV=3 CANONICAL=F1N0N5-1" }, "isoforms": [ { "isoform_ac": "F1N0N5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0N5/entry", "sequence": { "sequence": "MASEGLRGALTAVLGGRGLLVQNYDSGPAGEPPAPVRLRRNVCYVVLAVFLNEQDEVLLVQEAKKECRGSWYLPAGRMEPGETIVEALQREVKEEAGLQCEPLTLLSVEERGPSWIRFAFLTRPTGMAQQVAAWAEGSRHRSPGLYSGGILKTSKEADAESLQAGWYPRTSLPTPLRAQDILHLVDLAAQYRQRARHPLLLPQELPCSLVCQRLVATFTNVQTVWVLVGTVGTPHLPVTACGFTPMEQRGGIKMAVLRLLQECLSLHHLAVETQGLLGLQHLGKDLTDGICMNVLVTVAFRNPGLQNEPPKVRGENFFWWKVVEEDLQNQLLQRLRDSSVVPINR", "length": 345, "header": "tr|F1N0N5-1|F1N0N5_BOVIN Isoform 1 of Nudix hydrolase 18 OS=Bos taurus OX=9913 GN=NUDT18 PE=3 SV=3 CANONICAL=F1N0N5-1" }, "locus": { "chromosome": "8", "start_pos": 69423352, "end_pos": 69421128, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004527.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004527.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004527.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004527.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2393930", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2393930", "resource": "Reactome", "description": "Phosphate bond hydrolysis by NUDT proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "8-oxo-dGDP phosphatase activity", "id": "GO:0044715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044715", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "8-oxo-GDP phosphatase activity", "id": "GO:0044716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044716", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "8-hydroxy-dADP phosphatase activity", "id": "GO:0044717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044717", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "isoprenoid diphosphate phosphatase activity", "id": "GO:0106405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106405", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "dADP catabolic process", "id": "GO:0046057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046057", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "dGDP catabolic process", "id": "GO:0046067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046067", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "GDP catabolic process", "id": "GO:0046712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046712", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N0N5", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0N5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0N5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0N5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0N5" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 189, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0S2-1", "uniprot_ac": "F1N0S2", "uniprot_id": "F1N0S2_BOVIN", "mass": { "chemical_mass": 30457.0, "monoisotopic_mass": 30457.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101906182", "type": "recommended", "evidence": [ { "id": "F1N0S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase", "type": "recommended", "evidence": [ { "id": "F1N0S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S2/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "F1N0S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2#function" }, { "database": "UniProtKB", "id": "RU201113", "url": "https://www.uniprot.org/uniprotkb/RU201113#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101906182", "url": "https://www.uniprot.org/uniprotkb/F1N0S2", "locus": {} } ], "crossref": [ { "id": "F1N0S2", "url": "https://alphafold.ebi.ac.uk/entry/F1N0S2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000237", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03829", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03829", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ELPCKFG", "url": "https://omabrowser.org/oma/group/ELPCKFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45877:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45877:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21361", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21361", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21362", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21362", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0S2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0S2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRQTATALPTGTSQTGTTSCNSEWASLFQCPICFDYVLPPILQCHSGHLVWSNCRPKISRCPTCRDPLRSIRNLAMEKVADSVLFPCKYASSGCEITLTHTEKADHEEFCEFRPYSCPCPGASCKWQGSRDAVIPHLMHQHESITTLQGEDIVFLATGINLPGAVDWVMMQSCFGFHFILVLEKQEKYVGHHQFFAIVQLIGTRKQAEDFAYRLELNGPRRRLTWEATPRSTHEGIATAITNSDCLVFDTRVAQFFAENGNLGINVTISMC", "length": 272, "header": "tr|F1N0S2-1|F1N0S2_BOVIN Isoform 1 of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=LOC101906182 PE=3 SV=3 CANONICAL=F1N0S2-1" }, "isoforms": [ { "isoform_ac": "F1N0S2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0S2/entry", "sequence": { "sequence": "MSRQTATALPTGTSQTGTTSCNSEWASLFQCPICFDYVLPPILQCHSGHLVWSNCRPKISRCPTCRDPLRSIRNLAMEKVADSVLFPCKYASSGCEITLTHTEKADHEEFCEFRPYSCPCPGASCKWQGSRDAVIPHLMHQHESITTLQGEDIVFLATGINLPGAVDWVMMQSCFGFHFILVLEKQEKYVGHHQFFAIVQLIGTRKQAEDFAYRLELNGPRRRLTWEATPRSTHEGIATAITNSDCLVFDTRVAQFFAENGNLGINVTISMC", "length": 272, "header": "tr|F1N0S2-1|F1N0S2_BOVIN Isoform 1 of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=LOC101906182 PE=3 SV=3 CANONICAL=F1N0S2-1" }, "locus": { "chromosome": "5", "start_pos": 49018759, "end_pos": 49017944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000291.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000291.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042520.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042520.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N0S2", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0S2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 272, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0S2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0S2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0S2" }, { "id": "PS51081", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51081" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SIAH-type", "eco_id": "ECO_0000259", "start_pos": 83, "end_pos": 143, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0T1-1", "uniprot_ac": "F1N0T1", "uniprot_id": "F1N0T1_BOVIN", "mass": { "chemical_mass": 171247.0, "monoisotopic_mass": 171247.0 }, "refseq": {}, "gene_names": [ { "name": "LAMC3", "type": "recommended", "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ] } ], "protein_names": [ { "name": "Laminin subunit gamma-3", "type": "recommended", "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1/entry#names_and_taxonomy" } ] }, { "name": "Laminin-12 subunit gamma", "type": "synonym", "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1/entry#names_and_taxonomy" } ] }, { "name": "Laminin-14 subunit gamma", "type": "synonym", "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1/entry#names_and_taxonomy" } ] }, { "name": "Laminin-15 subunit gamma", "type": "synonym", "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.", "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1#function" }, { "database": "UniProtKB", "id": "ARBA00002418", "url": "https://www.uniprot.org/uniprotkb/ARBA00002418#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAMC3", "url": "https://www.uniprot.org/uniprotkb/F1N0T1", "locus": { "chromosome": "11", "start_pos": 101321914, "end_pos": 101225198, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017473", "url": "https://www.ensembl.org/id/ENSBTAG00000017473" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017473", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017473", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518914", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518914", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GAQKTCT", "url": "https://omabrowser.org/oma/group/GAQKTCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0T1", "url": "https://www.orthodb.org/?gene=F1N0T1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574:SF240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0T1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTAAALLLSLALLAPRAAGARMGACYDGAGRPQRCLPVFENAAFGRLAEASHTCGRPPEDFCPHVGAQGAGAPCQRCDAADPARHHNASYLTDFHSQDDSTWWQSPSMAFGVQYPTSVNITLNLGKAYEITYVRLKFHTSRPESFAIYKRSRAGGPWEPYQYYSASCQKTYGRPEGLFLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTELLVSLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDEEGRLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAANECLPCNCSGHSEECTFDRELFRSSGHGGRCLHCRAHTAGPHCERCQENFYRWSPQTPCQPCDCHPAGSLRLQCDDLGTCVCKPTVMGWKCDRCLSGFHSLSEGGCRPCTCNPVGSLGTCDPRSGRCHCKENVEGSLCDRCRPGAFNLQPHNPAGCSSCFCYGHSKVCVAAAQFQEHHILSDFRQGAEGWRAGSVGDPGHPARWSPGGLLLDPEDEEAELTAPEKFLGDQRFSYGQPLTLTFQVPRGSSLSTQLRLEGAGLALTLRHSGSPRTPVSGQAGEVRLKFLLQETSEDVDPPLSAFHFQRVLANLTALRIRTSGHSTSSSGPVLLTEVRLTSARRGLSPPASWVETCSCPQGYTGQFCESCAPGYKRNTPLGGPYASCVPCTCNQHGTCDPNTGVCLCGHHTEGPSCERCLPGFYGNPFTGQADDCQPCPCPGQSACTTIPESGEVVCTHCPRSQRGRRCEICDDGFFGDPLGLSGRPQPCQPCQCSGNVDPNAVGNCDPLSGRCLRCLHNTTGAHCGHCREGFYGSALAPRPADKCAPCSCNPEGSVSEQRPCDPVTGQCSCLPHVTGRDCGHCSPGFYDLQPGRGCRRCKCHPWGSQEDQCHPKTGQCPCRPGVEGQTCDRCQLGFFGFSVKGCRDCRCSPLGATSPQCHENSTCVCRPGFVGYKCDRCQDNFFLTASGRQCQECPSCYALVKEEAAKLKARLTLMEGWLQGSDCGRPWGPLDILQGEAPRGDIYQGPHLLQGAQEAFLEQVTGLEGAVKAAREQLQALGRSARCAQAGVEKTCIQLADLEAALESSEEEILHAATILASLVIPQEGLGQPTNWSKLATEAHALARRRVFSHSHRDTAAKIEATARRALLASNTSYALLWSLVEGRAALEAQQELEDRYQEVQAAQKALGTAVAEALPEAERVLAAVQQAGVAAALHLASPSAPASPPQKSQAEAVSLKVQTLEKTVTSREHMVTEAAGSLQATAQAVLQEMEPLTQLHQEARAALTRASSSVQAATVTVMGARTLLADVEGMKPRFPRPKDQAALRRKAAIVQDRILADSRKKTKQAERMLGDAASVSSRAKKKGREAELLAQDSAKLAKALLRAGKQEHRRASGLSSQTRATLGLASRQLLASEAHRQELEAAEWDGAGLSQMERQIRESRTSLEKDIKALLDLLARLGSLDTHRAPARALNETQWALERLRLRLSPPGALQGKLSLLEQESKLQELQIQSFENDLSELRADKQNLEAILHSLPESCASWQ", "length": 1583, "header": "tr|F1N0T1-1|F1N0T1_BOVIN Isoform 1 of Laminin subunit gamma-3 OS=Bos taurus OX=9913 GN=LAMC3 PE=4 SV=4 CANONICAL=F1N0T1-1" }, "isoforms": [ { "isoform_ac": "F1N0T1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1/entry", "sequence": { "sequence": "MGTAAALLLSLALLAPRAAGARMGACYDGAGRPQRCLPVFENAAFGRLAEASHTCGRPPEDFCPHVGAQGAGAPCQRCDAADPARHHNASYLTDFHSQDDSTWWQSPSMAFGVQYPTSVNITLNLGKAYEITYVRLKFHTSRPESFAIYKRSRAGGPWEPYQYYSASCQKTYGRPEGLFLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTELLVSLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDEEGRLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAANECLPCNCSGHSEECTFDRELFRSSGHGGRCLHCRAHTAGPHCERCQENFYRWSPQTPCQPCDCHPAGSLRLQCDDLGTCVCKPTVMGWKCDRCLSGFHSLSEGGCRPCTCNPVGSLGTCDPRSGRCHCKENVEGSLCDRCRPGAFNLQPHNPAGCSSCFCYGHSKVCVAAAQFQEHHILSDFRQGAEGWRAGSVGDPGHPARWSPGGLLLDPEDEEAELTAPEKFLGDQRFSYGQPLTLTFQVPRGSSLSTQLRLEGAGLALTLRHSGSPRTPVSGQAGEVRLKFLLQETSEDVDPPLSAFHFQRVLANLTALRIRTSGHSTSSSGPVLLTEVRLTSARRGLSPPASWVETCSCPQGYTGQFCESCAPGYKRNTPLGGPYASCVPCTCNQHGTCDPNTGVCLCGHHTEGPSCERCLPGFYGNPFTGQADDCQPCPCPGQSACTTIPESGEVVCTHCPRSQRGRRCEICDDGFFGDPLGLSGRPQPCQPCQCSGNVDPNAVGNCDPLSGRCLRCLHNTTGAHCGHCREGFYGSALAPRPADKCAPCSCNPEGSVSEQRPCDPVTGQCSCLPHVTGRDCGHCSPGFYDLQPGRGCRRCKCHPWGSQEDQCHPKTGQCPCRPGVEGQTCDRCQLGFFGFSVKGCRDCRCSPLGATSPQCHENSTCVCRPGFVGYKCDRCQDNFFLTASGRQCQECPSCYALVKEEAAKLKARLTLMEGWLQGSDCGRPWGPLDILQGEAPRGDIYQGPHLLQGAQEAFLEQVTGLEGAVKAAREQLQALGRSARCAQAGVEKTCIQLADLEAALESSEEEILHAATILASLVIPQEGLGQPTNWSKLATEAHALARRRVFSHSHRDTAAKIEATARRALLASNTSYALLWSLVEGRAALEAQQELEDRYQEVQAAQKALGTAVAEALPEAERVLAAVQQAGVAAALHLASPSAPASPPQKSQAEAVSLKVQTLEKTVTSREHMVTEAAGSLQATAQAVLQEMEPLTQLHQEARAALTRASSSVQAATVTVMGARTLLADVEGMKPRFPRPKDQAALRRKAAIVQDRILADSRKKTKQAERMLGDAASVSSRAKKKGREAELLAQDSAKLAKALLRAGKQEHRRASGLSSQTRATLGLASRQLLASEAHRQELEAAEWDGAGLSQMERQIRESRTSLEKDIKALLDLLARLGSLDTHRAPARALNETQWALERLRLRLSPPGALQGKLSLLEQESKLQELQIQSFENDLSELRADKQNLEAILHSLPESCASWQ", "length": 1583, "header": "tr|F1N0T1-1|F1N0T1_BOVIN Isoform 1 of Laminin subunit gamma-3 OS=Bos taurus OX=9913 GN=LAMC3 PE=4 SV=4 CANONICAL=F1N0T1-1" }, "locus": { "chromosome": "11", "start_pos": 101291687, "end_pos": 101225397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023245.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023245.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023245.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023245.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518914", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518914", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LIN4-1", "protein_name": "Laminin subunit gamma-3", "gene_name": "Lamc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGCRLPVSRPQMPSGSACWGGLWGLVERRGAKRRSRRRVDTGAVRSEAPAMAVSGILSRLATVVCVALVMLKAHCATGAGMGSCYDGAGRAQRCLPEFENAAFGRRAEASHTCGQPPEDFCPHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPSMAFGVQYPTSVNLTLHLGKAYEITYVRLKFHTSRPESFAIYKRTHTGGPWEPYQYYSASCQKTYGHPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGGRCKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEECTFDRELYRSTGHGGHCQRCRDHTAGPHCEHCEKNYYRWDPKTPCQPCDCHPAGSLSLQCDNSGTCPCKLTVTGWKCDRCLPGFHSLSEGGCRPCTCNVAGSLGTCDPRSGNCPCKENVEGGLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCAPASGFQEHHIRSDFRHGADGWQARSTEVSERPLQWSQSGILLGLRGGEELSAPEKFLGDQRLSYGQPLILTLQVPPGGSPPPMQLRLEGAGLSLALKPSNLPSSQDTRQPGRVQLQFLLQETSEEAEPPLPAFHFQRLLSNLTTLSIWTSGQGLGHSGHVLLCEVHLTSARPQRGLAPPASWVETCLCPQGYTGQFCEFCALGYKREIPHGGPYTNCIPCTCNQHGTCDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGHADDCQPCPCPGQSACTTIPESRDVVCTHCPPGQRGRRCESCEDGFFGDPLGLSGAPQPCRRCQCSRNVDLNAVGNCDPHSGRCLRCLHNTTGAHCEHCQEGFYGSALATRPADKCAPCSCDPRGSSSQKTCNPATGQCACLPYVTGRDCSRCSPGFYDLQPGRGCQSCKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDCRCSPLGAASPQCHENSTCVCRPGFVGYKCDRCQDNFFLVDGDTGCQECPTCYALVKEEAAKLKTRLMLMEGWLQGSECGSPWGPLDILQGEAPRGDVYQGHHLFQEARGTFLEQMVGLEESVKATWEQLQVLRGNAHCAQAGAQKTCNQLAELGETLRSSEEEVLRAASALSFLANLQEGSSAPTNWGRLASEAYILTRSHRDTATKIEATVERALLASNTSYELLWKLLKGSVASEAQQELEERYQEVQAAQTALGIAVAEALPKAEKALATVKQVVGAAAPRLGSMVTPEAMDSQARYLGRRVKALEQKLQQNQAGQAVGALQVEAGRALRKVEPFLQLRNKTTAALTQVSSAVQAAKVTVIGAKTLLADLEALADFAGMKLRFPLPKEQAALKRKAGSIRTRLLKDTKRKTKQAERMLGNAASLSSNSQKRSKEAELMSKENAKLARAFLREGKQNYRHASRLASQTQATLRQASRLVLTSEARKQELEEAKQVASGLSTVERQIRESRISLEKDTKVLSELLAKLGSLGTHQAPAQTLNETQQALESLRLQLDSHGSLHHKLRQLEEESARQELQIQSFENDLAEIRADKHNLETILSSLPENCAS", "length": 1637 }, "evidence": [ { "id": "F1N0T1", "url": "https://omabrowser.org/oma/group/F1N0T1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QPJ1-1", "protein_name": "Laminin subunit gamma-3", "gene_name": "lamc3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDSSALHSLLLLLFASVYFVFAGMDSCYDENGVPSLCLPKFENAAFNHSVMVSNMCGIPPEDYCMQTGSTRSCHHCDAFDSELNRNATYLTDFHTDEEPTWWQSQSMFYGVQYPNSVNITLHLGKAFEITYVRLKFYTSRPESFAIYKRTDENGPWQPYQYYSASCRKTYGRDNKGFIRPGDNERTPLCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDQSLVLQDWVTATDILISLDRLNTFGDEFFKDAKVLRSYFYAISDFSVGGRCKCNGHASECVVNEEGRSVCVCEHNTAGVDCQLCAPFYQDRPWARATAHSANECVRCNCSGLADECVFDVEQYRSTGQGGRCLGCRENTAGPHCEQCRENYFRSSALQPCQNCNCNALGSVSLQCDADGVCVCWPSVSGVKCDICKSGFHSLGPGGCRLCDCDERGSVGVCSAEDGRCHCKANVEGQSCNRCKPGSFNLQLENPDGCNKCFCFGHSLACFSSNQYTPIYITSDFLEDPDGWKGVFSRAHEQSLIWKEGEVYLLPYREENGFYKAPDKYLGNMLLSYGRTLSMSFTAELEELLPRSVTVRLEGSGMSVSADLHTQQEPYSQLEKTPINSFSLRLTEKHVNPSVSSFEFLRMLYNLTALHISNAGGQNYTSQLSRVSLESAVQKAYHPDVLPHALWVEVCSCPAGFAGQFCQLCAPGFTRETPDGGPFSPCVPCNCNQHGTCHPETGVCACTDFTTGRHCERCEDGYYGNALTGSPGDCLPCPCPDRTTCAQVPETGDVICTNCPTGQRGVRCELCEDGFYGNPLGWGGTVQPCVKCQCNGNVDANAVGVCDHMTGRCLKCLGHTTGDHCEKCRLGYYGNALANQLNPERKCKPCACNVAGTSGSPNDCHPNTGNCVCLGHVTGRDCGQCEAGYFNLQPGLGCEMCNCNPIGSLSSACHPITGQCMCRTGVEGMSCDTCRMGFFGFSSRGCRACNCDPMGSTSMQCHNNGTCSCRNGFVGYKCDKCEQNYYQNRLSHQCEECPVCYSIIRDQASKLKARLQELELLLSSYDCNRYSRQYRGHQQHRHQHNDLDNHIQKDQVEDYLPNALEDLLAIQEAREAFIKQFSQLETSAQTLQLQLRNIATALNCNLTNFAKHPEEGKTQKVENECRELVDTLSTALNMQDQLQKMTVELNSMAIPAVIPKEPNKWNAIVNESEVLVKSHTDMAAHIEQVAEDVFKMANRTYLQLVTLLEDNSTESHIQDLTEKLEEMQQLKENLTLEVNETLVTHLSLQKHNAEIADILHNITASLSELRRTDGNFTLVVEETNMTSFSQTFNQTNVTAAQNPQLTESEDLMNRTTNLDISVQSKEHLVNKTREEIQPDMDSAKNNLKTVQELKQLTAAVEGLKVSAVSSVVTGKEVEAEILSLQKSLQDMEQDWPQLPTLSKSFLKREKMLNEKTLVEVKKRVKQTEKMIKPSVENATDADSTAKQAEASADTVAKDAKASFTQGKRIKHASGQLRSALDVTLEQLSELESQTALKQATLEAEEDMVSSSSVIDSMETAKNQLESFTDMLTLLLSQMEADVVLENYDRILNETAVRLRVLQGAVESPSLTGKIQRLRNAASDQEKQMQNLEESLQDIRKERDSLTDIAQNLPKTCPQKGH", "length": 1643 }, "evidence": [ { "id": "F1N0T1", "url": "https://omabrowser.org/oma/group/F1N0T1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P15215-1", "protein_name": "Laminin subunit gamma-1", "gene_name": "LanB2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKRSRWSHSGSSTARLLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNCERCKENFYMRDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIARTPVTNDDEFEAKLKAVQEKVAVLAQDARDNSGDGGQTYAEVIDDLHKHLDSVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSEVGLELSHVKQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELSNSNGELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSCFSRNRLEP", "length": 1639 }, "evidence": [ { "id": "F1N0T1", "url": "https://omabrowser.org/oma/group/F1N0T1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9R0B6-1", "protein_name": "Laminin subunit gamma-3", "gene_name": "Lamc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVSRVLSLLATVASMALVIQETHFAAGADMGSCYDGVGRAQRCLPEFENAAFGRRAEASHTCGRPPEDFCPHVGAPGAGLQCQRCDDADPGRRHDASYLTDFHSPDDSTWWQSPSMAFGVQYPTSVNLTLSLGKAYEITYVRLKFHTSRPESFAIYKRTYASGPWEPYQYYSASCQKTYGRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDILISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGGRCKCNGHASECEPNAAGQLACRCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEECTFDRELYRSTGHGGHCQRCRDHTTGPHCERCEKNYYRWSPKTPCQPCDCHPAGSLSLQCDNSGVCPCKPTVTGWKCDRCLPGFHSLSEGGCRPCACNVAGSLGTCDPRSGNCPCKENVEGSLCDRCRPGTFNLQPHNPVGCSSCFCYGHSKVCSPAAGFQEHHIRSDFRHGAGGWQIRSMGVSKRPLQWSQSGLLLGLRGGEELSAPKKFLGDQRLSYGQPVILTLQVPPGGSPPPIQLRLEGAGLALSLRPSSLPSPQDTRQPRRVQLQFLLQETSEEAESPLPTFHFQRLLSNLTALSIWTSGQGPGHSGQVLLCEVQLTSAWPQRELAPPASWVETCLCPQGYTGQFCEFCALGYKREIPHGGPYANCIPCTCNQHGTCDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGRADDCQPCPCPGQSACATIPESGDVVCTHCPPGQRGRRCESCEDGFFGDPLGLSGAPQPCRRCQCSGNVDLNAVGNCDPHSGHCLRCLYNTTGAHCEHCREGFYGSAVATRPVDKCAPCSCDLRGSVSEKTCNPVTGQCVCLPYVSGRDCSRCSPGFYDLQSGRGCQSCKCHPLGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDCRCSPLGAASSQCHENSTCVCRPGFVGYKCDRCQDNFFLADGDTGCQECPTCYALVKEEAAKLKARLMLMEGWLQRSDCGSPWGPLDILQGEAPLGDVYQGHHLLQETRGTFLQQMVGLEDSVKATWEQLQVLRGHVHCAQAGAQKTCIQLAELEETLQSSEEEVLRAASALSFLASLQKGSSTPTNWSHLASEAQILARSHRDTATKIEATSERALLASNASYELLKLMEGRVASEAQQELEDRYQEVQAAQTALGIAVAEALPKAEKALATVKQVIGDAAPHLGLLVTPEAMNFQARGLSWKVKALEQKLEQKEPEVGQSVGALQVEAGRALEKMEPFMQLRNKTTAAFTRASSAVQAAKVTVIGAETLLADLEGMKLRSPLPKEQAALKKKAGSIRTRLLEDTKRKTKQAERMLGNAASLSSSTKKKSKEAELMSKDNAKLSRALLREGKQGYRHASRLASQTQATLRRASRLLLTSEAHKQELEEAKQVTSGLSTVERQIRESRISLEKDTKVLSELLVKLGSLGVHQAPAQTLNETQRALESLRLQLDSHGALHHKLRQLEEESARQELQIQSFEDDLAEIRADKHNLETILSSLPENCAS", "length": 1581 }, "evidence": [ { "id": "F1N0T1", "url": "https://omabrowser.org/oma/group/F1N0T1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y6N6-1", "protein_name": "Laminin subunit gamma-3", "gene_name": "LAMC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAALLLGLALLAPRAAGAGMGACYDGAGRPQRCLPVFENAAFGRLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGVLLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYLALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFESDLAEIRADKQNLEAILHSLPENCASWQ", "length": 1575 }, "evidence": [ { "id": "F1N0T1", "url": "https://omabrowser.org/oma/group/F1N0T1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "animal organ morphogenesis", "id": "GO:0009887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887", "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ], "pmid": "" }, { "name": "tissue development", "id": "GO:0009888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009888", "evidence": [ { "database": "UniProtKB", "id": "F1N0T1", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1153, "end_pos": 1155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1193, "end_pos": 1195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1514, "end_pos": 1516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 839, "end_pos": 841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" }, { "start_pos": 982, "end_pos": 984, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" }, { "id": "PS50027", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50027" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin EGF-like", "eco_id": "ECO_0000259", "start_pos": 272, "end_pos": 327, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" }, { "id": "PS51115", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin IV type A", "eco_id": "ECO_0000259", "start_pos": 507, "end_pos": 674, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0T1" }, { "id": "PS51117", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin N-terminal", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 271, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1153, "end_pos": 1155 }, { "start_pos": 1193, "end_pos": 1195 }, { "start_pos": 120, "end_pos": 122 }, { "start_pos": 1514, "end_pos": 1516 }, { "start_pos": 296, "end_pos": 298 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 632, "end_pos": 634 }, { "start_pos": 839, "end_pos": 841 }, { "start_pos": 88, "end_pos": 90 }, { "start_pos": 982, "end_pos": 984 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0U0-1", "uniprot_ac": "F1N0U0", "uniprot_id": "F1N0U0_BOVIN", "mass": { "chemical_mass": 98202.0, "monoisotopic_mass": 98202.0 }, "refseq": {}, "gene_names": [ { "name": "PDE6B", "type": "recommended", "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ] } ], "protein_names": [ { "name": "Phosphodiesterase", "type": "recommended", "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.-", "type": "synonym", "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDE6B", "url": "https://www.uniprot.org/uniprotkb/F1N0U0", "locus": { "chromosome": "6", "start_pos": 117653872, "end_pos": 117685792, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017480", "url": "https://www.ensembl.org/id/ENSBTAG00000017480" } ] } } ], "crossref": [ { "id": "F1N0U0", "url": "https://alphafold.ebi.ac.uk/entry/F1N0U0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017480", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017480", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "REVYDCE", "url": "https://omabrowser.org/oma/group/REVYDCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11347", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11347", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00233", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00233", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01590", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01590", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2485179", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2485179", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2514859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086398", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B957", "url": "https://www.uniprot.org/uniprotkb/E1B957", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B957-1", "url": "https://www.uniprot.org/uniprotkb/E1B957-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0U0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0U0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLSEGQVHRFLDQNPGFADQYFGRKLSPEDVANACEDGCPEGCTSFRELCQVEESAALFELVQDMQENVNMERVVFKILRRLCSILHADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVQDVMECPHFSSFADELTDYVTRNILATPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFLKYLNFGTLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQAYSGPRTPDGREILFYKVIDYILHGKEDIKVIPSPPADHWALASGLPTYVAESGFICNIMNAPADEMFNFQEGPLDDSGWIVKNVLSMPIVNKKEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDREEIQLILPTRERLGKEPADCEEDELGKILKEVLPGPAKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEDQKKETTAKKVGTEICNGGPAPRSSTCRIL", "length": 852, "header": "tr|F1N0U0-1|F1N0U0_BOVIN Isoform 1 of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE6B PE=3 SV=3 CANONICAL=F1N0U0-1" }, "isoforms": [ { "isoform_ac": "E1B957-1", "url": "https://www.uniprot.org/uniprotkb/E1B957/entry", "sequence": { "sequence": "MSLSEGQVHRFLDQNPGFADQYFGRKLSPEDVANACEDGCPEGCTSFRELCQVEESAALFELVQDMQENVNMERVVFKILRRLCSILHADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVQDVMECPHFSSFADELTDYVTRNILATPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFLKYLNFGTLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQAYSGPRTPDGREILFYKVIDYILHGKEDIKVIPSPPADHWALASGLPTYVAESGFICNIMNAPADEMFNFQEGPLDDSGWIVKNVLSMPIVNKKEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDREEIQLILVPEEQAGLRRACPSAPPSLPQKEVLPGPAKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVRAHLEMIRIPVPAGSLGASHVRQESGHLSLQTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEDQKKETTAKKGLGPARGPSQGILEGRHLYKGEESQLRNSVPIINQRFPLK", "length": 867, "header": "tr|E1B957-1|E1B957_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE6B PE=3 SV=3 CANONICAL=F1N0U0-1" }, "locus": { "chromosome": "6", "start_pos": 117685744, "end_pos": 117654758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052174.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052174.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052098.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052098.3" } ] } }, { "isoform_ac": "F1N0U0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0U0/entry", "sequence": { "sequence": "MSLSEGQVHRFLDQNPGFADQYFGRKLSPEDVANACEDGCPEGCTSFRELCQVEESAALFELVQDMQENVNMERVVFKILRRLCSILHADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVQDVMECPHFSSFADELTDYVTRNILATPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFLKYLNFGTLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQAYSGPRTPDGREILFYKVIDYILHGKEDIKVIPSPPADHWALASGLPTYVAESGFICNIMNAPADEMFNFQEGPLDDSGWIVKNVLSMPIVNKKEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDREEIQLILPTRERLGKEPADCEEDELGKILKEVLPGPAKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEDQKKETTAKKVGTEICNGGPAPRSSTCRIL", "length": 852, "header": "tr|F1N0U0-1|F1N0U0_BOVIN Isoform 1 of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE6B PE=3 SV=3 CANONICAL=F1N0U0-1" }, "locus": { "chromosome": "6", "start_pos": 117685744, "end_pos": 117654262, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023239.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023239.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023239.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023239.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2485179", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2485179", "resource": "Reactome", "description": "Activation of the phototransduction cascade" }, { "id": "R-BTA-2514859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2514859", "resource": "Reactome", "description": "Inactivation, recovery and regulation of the phototransduction cascade" }, { "id": "R-BTA-4086398", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "resource": "Reactome", "description": "Ca2+ pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T414-1", "protein_name": "Phosphodiesterase", "gene_name": "PDE6B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLNEEQVQEFLDQNPSFTDQYFGKKLSPENVASACEDRCPEGGASFRELCQVEESAALFELVQDMQESVNMERVVFKLLRRLCSILQADRCSLFMYRQRNGTAELATRLFSVQPDSVLEDCLVPADSEIVFPLDIGVVGHVAQTKKTVNVEDVRECPHFSSFADELTDYVTRNLLATPVMNGKDVVAVIMAVNKLNGPCFTSEDEDVFLKYLNFGTLNLKIYHLNYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREILFYKVIDYILHGKEDIKVIPSPPADHWALASGLPTYVAESGFICNIMNAPADEMFKFQDGPLDDSGWTIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVLNTDTYDRMNKLENRKDIAQDMVLYHVKCDKDEIQSILPTRERFGKEPADCEEDELGKLLKEVLPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEDEQQKEEAQTAAKKAGTEVCNGGPAPKSSTCCIL", "length": 856 }, "evidence": [ { "id": "F1N0U0", "url": "https://omabrowser.org/oma/group/F1N0U0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0AC58IAR7-1", "protein_name": "Phosphodiesterase", "gene_name": "pde6b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVKKEDVEKFLDGNPDFTKTYFDKKLKPGAVASIMRVPESKVDMDSFKEIVSVEEGAIFYDLITDMQENVNMEKVIFKILKRISALIHADRCSLFMYRQRNGIAELATRLFNVNKDSELDDCVVAPDSEIVFPLDIGIVGHVAQTKKQVNVKDVTQDSHFSTFVDELTEYTTHNLLAAPIMNGKDVVAVIMAVNKTTGPHFTDEDMDLFLKYLKVGSLNLKIFHLSYLHNCETRKGQLLLWSANKVFEELTDIERQFHKALYTVRAYLNCDRYSVGLLDMTKEKEFFDIWPVLMGEQPPYSGPVTPDGREIIFYKVIDYILHGKEDIKVIPNPTADHWALASGLPTYVAESGFICNIMNAASEEMFKFQTEALDDSGWTIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDEHDEQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQDMVLYHVKCRDDEIQDILKTREYFDREPRDCEEEELLEILKKELPGPKKFEIYAFHFSDFDCTELQLVMCGIQMYYEVGVVKKFQVPQEVLVRFMYSVSKGYRRITYHNWRHGFNVGQTMFTLLTTGKLKQYYTDLEVMAMITAGFLHDIDHRGTNNLYQVKSQNPLAKLHGSSILERHHLEFGKFLLGEESLNIFQNLNRRQTEHVFHLIDIAIIATDLALYFKKRTMFQKIVDLSETYEERKKWIDFMSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAAELPKLQCGFIDFVCTFVYKEFSRFHPEIKPMFDGILNNRMHWKERQEEYEAKLKAMEEAVKARQEAAAKNGLNNMSRLLNIHCICTRLDIRHTEKTYNVVILLINHGLCHCDQVWTPLQSAIYMLSIEISFESFLIVYYVIFNNNA", "length": 912 }, "evidence": [ { "id": "F1N0U0", "url": "https://omabrowser.org/oma/group/F1N0U0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZDI8-1", "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "gene_name": "Pde6b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLSEEQVRSFLDGNPTFAHQYFEKKLSPENVAGACEGGCLVDCGSLRELCQVEESAALFELVQDMQESVNMERVVFKVLRRLCTILHADRCSLFMYRQRNGVAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSPFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALTSGLPTYVAESGFICNIMNASADEMFNFQEGPLDESGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKAGTEICNGGPAPKSSTCCIL", "length": 856 }, "evidence": [ { "id": "F1N0U0", "url": "https://omabrowser.org/oma/group/F1N0U0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P23440-1", "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "gene_name": "Pde6b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGACEDGWLADCGSLRELCQVEESAALFELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSSFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALASGLPTYVAESGFICNIMNASADEMFNFQEGPLDDSGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCNGGPAPKSSTCCIL", "length": 856 }, "evidence": [ { "id": "F1N0U0", "url": "https://omabrowser.org/oma/group/F1N0U0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P35913-1", "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "gene_name": "PDE6B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL", "length": 854 }, "evidence": [ { "id": "F1N0U0", "url": "https://omabrowser.org/oma/group/F1N0U0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "negative regulation of cAMP/PKA signal transduction", "id": "GO:0141162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141162", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "entrainment of circadian clock by photoperiod", "id": "GO:0043153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043153", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "3',5'-cyclic-GMP phosphodiesterase activity", "id": "GO:0047555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047555", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "3',5'-cyclic-AMP phosphodiesterase activity", "id": "GO:0004115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004115", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "3',5'-cyclic-nucleotide phosphodiesterase activity", "id": "GO:0004114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004114", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "photoreceptor disc membrane", "id": "GO:0097381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097381", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" }, { "name": "photoreceptor outer segment membrane", "id": "GO:0042622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042622", "evidence": [ { "database": "UniProtKB", "id": "F1N0U0", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-2584246", "name": "GNAT1-GTP hydrolyses its bound GTP to GDP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, photoreceptor disc membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04695-1", "F1N0U0-1", "E1BK80-1" ], "evidence": [ { "id": "R-BTA-2584246", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2584246" } ] }, { "id": "R-BTA-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-30991" ], "output_participant_list": [], "enzyme_list": [ "F1N0U0-1", "E1BK80-1" ], "evidence": [ { "id": "R-BTA-4086392", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086392" } ] }, { "id": "R-BTA-74059", "name": "PDE6 hydrolyses cGMP to GMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, photoreceptor disc membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04695-1", "F1N0U0-1", "E1BK80-1" ], "evidence": [ { "id": "R-BTA-74059", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74059" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-30991", "participant_name": "cGMP [cytosol]", "crossref": [ { "id": "57746", "database": "ChEBI", "url": "" }, { "id": "ZINC000004095501", "database": "ZINC", "url": "" }, { "id": "C00942", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1BK80", "gene_name": "PDE6A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "E1BK80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK80" } ] } ] }, { "uniprot_ac": "F1N0U0", "gene_name": "PDE6B", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0U0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 852, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0U0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0U0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" }, { "id": "PS51845", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51845" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDEase", "eco_id": "ECO_0000259", "start_pos": 480, "end_pos": 813, "start_aa": "Glu", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" }, { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 560, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 560, "end_pos": 560, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 591, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 591, "end_pos": 591, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 592, "amino_acid": "Ala", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 592, "end_pos": 592, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" }, { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 596, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 596, "end_pos": 596, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" }, { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 597, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 597, "end_pos": 597, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 712, "amino_acid": "Met", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 712, "end_pos": 712, "start_aa": "Met", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0U0" }, { "id": "PIRSR623088-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR623088-3" } ], "binding_site_uniprot": 717, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 717, "end_pos": 717, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0W3-1", "uniprot_ac": "F1N0W3", "uniprot_id": "F1N0W3_BOVIN", "mass": { "chemical_mass": 21227.0, "monoisotopic_mass": 21227.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Large ribosomal subunit protein uL22", "type": "recommended", "evidence": [ { "id": "F1N0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0W3/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L17", "type": "synonym", "evidence": [ { "id": "F1N0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0W3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0W3", "url": "https://www.uniprot.org/uniprotkb/F1N0W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1N0W3", "locus": {} } ], "crossref": [ { "id": "F1N0W3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0W3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034973", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034973", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00336", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00336", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018260", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018260", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TEMILME", "url": "https://omabrowser.org/oma/group/TEMILME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11593:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11593:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0W3", "url": "https://www.uniprot.org/uniprotkb/F1N0W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0W3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0W3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMYIRKATKYLKDVTLKKQCVPFRCYNGGVGSCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNTAPKMRHRTYRAHGQINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184, "header": "tr|F1N0W3-1|F1N0W3_BOVIN Isoform 1 of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=F1N0W3-1" }, "isoforms": [ { "isoform_ac": "F1N0W3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0W3/entry", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMYIRKATKYLKDVTLKKQCVPFRCYNGGVGSCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNTAPKMRHRTYRAHGQINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184, "header": "tr|F1N0W3-1|F1N0W3_BOVIN Isoform 1 of Large ribosomal subunit protein uL22 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=F1N0W3-1" }, "locus": { "chromosome": "7", "start_pos": 2398252, "end_pos": 2397701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019827.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019827.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019827.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019827.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "F1N0W3", "url": "https://www.uniprot.org/uniprotkb/F1N0W3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "F1N0W3", "url": "https://www.uniprot.org/uniprotkb/F1N0W3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "F1N0W3", "url": "https://www.uniprot.org/uniprotkb/F1N0W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0W3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 184, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0W3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0W3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0W7-1", "uniprot_ac": "F1N0W7", "uniprot_id": "F1N0W7_BOVIN", "mass": { "chemical_mass": 69873.0, "monoisotopic_mass": 69873.0 }, "refseq": { "ac": "XP_002697870", "name": "RNA-binding E3 ubiquitin-protein ligase MEX3C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697870" }, "gene_names": [ { "name": "MEX3C", "type": "recommended", "evidence": [ { "id": "F1N0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ] }, { "name": "MEX3C", "type": "synonym", "evidence": [ { "id": "XP_002697870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697870" } ] } ], "protein_names": [ { "name": "Mex-3 RNA binding family member C", "type": "synonym", "evidence": [ { "id": "F1N0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0W7/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding E3 ubiquitin-protein ligase MEX3C", "type": "synonym", "evidence": [ { "id": "XP_002697870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697870" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEX3C", "url": "https://www.uniprot.org/uniprotkb/F1N0W7", "locus": { "chromosome": "24", "start_pos": 50647969, "end_pos": 50667933, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014886", "url": "https://www.ensembl.org/id/ENSBTAG00000014886" } ] } } ], "crossref": [ { "id": "F1N0W7", "url": "https://alphafold.ebi.ac.uk/entry/F1N0W7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014886", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014886", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16722", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16722", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22423", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22423", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22424", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22424", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529318", "url": "https://www.ncbi.nlm.nih.gov/gene/529318", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529318", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529318", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GLPCNPN", "url": "https://omabrowser.org/oma/group/GLPCNPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0W7", "url": "https://www.orthodb.org/?gene=F1N0W7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23285", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23285", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23285:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23285:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00013", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00013", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697870", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697870", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0W7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0W7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSGSSAALALAAAPAPLPQPPPPPPPLPPPPPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPAIRAAAAQGPARRAAGPSPEERAPPGRPGVSEAAELELEEEEDDDDEEEEEGEDAELDGDLLEEEELEEAEEEGRPSLLLLSPPAAAASQTQPIPGGSLGSVLLPAAGFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPPGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS", "length": 666, "header": "tr|F1N0W7-1|F1N0W7_BOVIN Isoform 1 of Mex-3 RNA binding family member C OS=Bos taurus OX=9913 GN=MEX3C PE=4 SV=3 CANONICAL=F1N0W7-1" }, "isoforms": [ { "isoform_ac": "F1N0W7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0W7/entry", "sequence": { "sequence": "MPSGSSAALALAAAPAPLPQPPPPPPPLPPPPPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPAIRAAAAQGPARRAAGPSPEERAPPGRPGVSEAAELELEEEEDDDDEEEEEGEDAELDGDLLEEEELEEAEEEGRPSLLLLSPPAAAASQTQPIPGGSLGSVLLPAAGFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPPGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS", "length": 666, "header": "tr|F1N0W7-1|F1N0W7_BOVIN Isoform 1 of Mex-3 RNA binding family member C OS=Bos taurus OX=9913 GN=MEX3C PE=4 SV=3 CANONICAL=F1N0W7-1" }, "locus": { "chromosome": "24", "start_pos": 50667734, "end_pos": 50648973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019818.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019818.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019818.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019818.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529318", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529318", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNU9-1", "protein_name": "Mex-3 RNA binding family member C", "gene_name": "MEX3C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPSGSSAALALAAAPAPLPQPPPPPPPPPLPPPAAGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAAAAQSQARRAAGLSPEERAPPGRPGVSESAELELEEDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAAAASQTQPIPGGSLGSVLLPAAGFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTPTQTIWTPFEPVNPLSGFGSDPPGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS", "length": 655 }, "evidence": [ { "id": "F1N0W7", "url": "https://omabrowser.org/oma/group/F1N0W7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A2R5-1", "protein_name": "Mex-3 RNA binding family member C", "gene_name": "Mex3c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSGSSAALALAAAPAPLPQPPPLPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAAAAAAQCQARRAAGLAPEEPGRLATSETAELELEVDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAATASQTQPIPGGPLGSVLLPAAGFDAREAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMMSNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS", "length": 646 }, "evidence": [ { "id": "F1N0W7", "url": "https://omabrowser.org/oma/group/F1N0W7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q05A36-1", "protein_name": "RNA-binding E3 ubiquitin-protein ligase MEX3C", "gene_name": "Mex3c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSGSSAALALALAAAPAPLPQPPPLPPPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAAAVAAAAAAQCQARRATGLAPEEPGRLATSETAELELEVDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAATASQTQPIPGGPLGSVLLPAAGFDAREAAAAGVLYGGDDAQGMMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMMSNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLTVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS", "length": 652 }, "evidence": [ { "id": "F1N0W7", "url": "https://omabrowser.org/oma/group/F1N0W7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5U5Q3-1", "protein_name": "RNA-binding E3 ubiquitin-protein ligase MEX3C", "gene_name": "MEX3C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPEAAELELEEDEEEGEEAELDGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGGSLGSVLLPAARFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS", "length": 659 }, "evidence": [ { "id": "F1N0W7", "url": "https://omabrowser.org/oma/group/F1N0W7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N0W7", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0W7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 666, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0W7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0W7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0W7" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 615, "end_pos": 655, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 589, "end_pos": 591 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0X0-1", "uniprot_ac": "F1N0X0", "uniprot_id": "F1N0X0_BOVIN", "mass": { "chemical_mass": 129955.0, "monoisotopic_mass": 129955.0 }, "refseq": {}, "gene_names": [ { "name": "PCDH12", "type": "recommended", "evidence": [ { "id": "F1N0X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ] } ], "protein_names": [ { "name": "Protocadherin-12", "type": "recommended", "evidence": [ { "id": "F1N0X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X0/entry#names_and_taxonomy" } ] }, { "name": "Vascular cadherin-2", "type": "synonym", "evidence": [ { "id": "F1N0X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X0/entry#names_and_taxonomy" } ] }, { "name": "Vascular endothelial cadherin-2", "type": "synonym", "evidence": [ { "id": "F1N0X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Acts as a regulator of cell migration, probably via increasing cell-cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0#function" }, { "database": "UniProtKB", "id": "ARBA00059072", "url": "https://www.uniprot.org/uniprotkb/ARBA00059072#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDH12", "url": "https://www.uniprot.org/uniprotkb/F1N0X0", "locus": { "chromosome": "7", "start_pos": 53008893, "end_pos": 53021354, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008437", "url": "https://www.ensembl.org/id/ENSBTAG00000008437" } ] } } ], "crossref": [ { "id": "F1N0X0", "url": "https://alphafold.ebi.ac.uk/entry/F1N0X0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008437", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008437", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ALFMSIC", "url": "https://omabrowser.org/oma/group/ALFMSIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0X0", "url": "https://www.orthodb.org/?gene=F1N0X0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0X0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMRFLSLLGLLGPGGYLFLSGDCQEVATLTVRYQVAEEVPSGTVIGKLPQERGREEEPGQAGAAFQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRQQDPCLVSFDVLATGERALIHVEIQVLDINDHQPQFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHSYTLSPSEHFALDVIVGPDQTKHAELVVVKELDREIHSYFDLVLTAYDSGNPPKSGTSLVKVSVLDSNDNSPVFAESSLALEIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHVPLEVLNTFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPNPIPAHCKILIKVLDVNDNAPSIHITWASQPLLVSEALPKDSFIALIMANDLDSGNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPQYTLTLLAQDQGPQPLSDKKQLSIQISDANDNAPVFEKSRYQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQLSSSVSVWVSLLDANDNAPEVIHPILSNGRASLSVLVNASTGHLLVPIENPNGLGPAGTDIPLQATSSSRPFLLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINVTNASSLTGSEWELEIVVEDRGSPSLQTRALLQVLFVTSVDHLRDSAREPGALSTSVLTVICLVVLLAVFGSILALITSICRTEKKDNRAYNCREAESTYRHQPKRPQKQIQKADIQLVPMLRGQVDEPGEVGQPPKHVGEEAMMEAGWDSCLQAPFHLTPTLYRTLRNQGNQGTLAESREVLQDTVNLLFNHPRQRNASRENLHLAEPQPAVGQPRSRLLKAAGSPTGRVPGDQGSEEAPQSPPASSATLRRQRNLNGKVAPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGSSRSTIPDTDGPGARAGGQAEPDQEEGPLDPEEDLSVKQLLEEELSNLLDPHTGLALDRLSVPDPAWMARLSLPLSTNYRDNVFSPDAATSEEPRTFQTFGKAPELSPTGTRLASTFLSEMSSLLEMLLEQRPAVPVEAASEVLRRLSVCGRTLSLDLATSGAAGSEGLTGLAGNKGAESRTSSGSSSSRGQWIQEPGTLGDVRKPRP", "length": 1197, "header": "tr|F1N0X0-1|F1N0X0_BOVIN Isoform 1 of Protocadherin-12 OS=Bos taurus OX=9913 GN=PCDH12 PE=4 SV=1 CANONICAL=F1N0X0-1" }, "isoforms": [ { "isoform_ac": "F1N0X0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X0/entry", "sequence": { "sequence": "MMRFLSLLGLLGPGGYLFLSGDCQEVATLTVRYQVAEEVPSGTVIGKLPQERGREEEPGQAGAAFQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRQQDPCLVSFDVLATGERALIHVEIQVLDINDHQPQFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHSYTLSPSEHFALDVIVGPDQTKHAELVVVKELDREIHSYFDLVLTAYDSGNPPKSGTSLVKVSVLDSNDNSPVFAESSLALEIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHVPLEVLNTFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPNPIPAHCKILIKVLDVNDNAPSIHITWASQPLLVSEALPKDSFIALIMANDLDSGNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPQYTLTLLAQDQGPQPLSDKKQLSIQISDANDNAPVFEKSRYQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQLSSSVSVWVSLLDANDNAPEVIHPILSNGRASLSVLVNASTGHLLVPIENPNGLGPAGTDIPLQATSSSRPFLLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINVTNASSLTGSEWELEIVVEDRGSPSLQTRALLQVLFVTSVDHLRDSAREPGALSTSVLTVICLVVLLAVFGSILALITSICRTEKKDNRAYNCREAESTYRHQPKRPQKQIQKADIQLVPMLRGQVDEPGEVGQPPKHVGEEAMMEAGWDSCLQAPFHLTPTLYRTLRNQGNQGTLAESREVLQDTVNLLFNHPRQRNASRENLHLAEPQPAVGQPRSRLLKAAGSPTGRVPGDQGSEEAPQSPPASSATLRRQRNLNGKVAPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGSSRSTIPDTDGPGARAGGQAEPDQEEGPLDPEEDLSVKQLLEEELSNLLDPHTGLALDRLSVPDPAWMARLSLPLSTNYRDNVFSPDAATSEEPRTFQTFGKAPELSPTGTRLASTFLSEMSSLLEMLLEQRPAVPVEAASEVLRRLSVCGRTLSLDLATSGAAGSEGLTGLAGNKGAESRTSSGSSSSRGQWIQEPGTLGDVRKPRP", "length": 1197, "header": "tr|F1N0X0-1|F1N0X0_BOVIN Isoform 1 of Protocadherin-12 OS=Bos taurus OX=9913 GN=PCDH12 PE=4 SV=1 CANONICAL=F1N0X0-1" }, "locus": { "chromosome": "7", "start_pos": 53021318, "end_pos": 53009275, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011099.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011099.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011099.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011099.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YAD8-1", "protein_name": "Protocadherin-12", "gene_name": "PCDH12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRRQSGEPTATCWAMGTLGGLLLLGRSALQLRALWWLLFLSTDAQEVATITVQYRLFEEVPEGTVIGTLAEHFEHGESGEMGENFRLLQSPGMFPLHVESGDGELSTAGRVDREQLCRHSDPCWVSFDVLAAEQLALIHVEVQVLDINDHAPRFPTPELELEMSESASLQMHIPLDRALDADTGPNAHCSYALSPSEHFALEVVSGSDGTKHAELVVIKEVDRELHSSFDLVLTAADHGEPPRSGTALIKVIVLDSNDNSPVFAESSLVVEVREDALLGTLLVTVTATDPDQGPNGEIEYSLSKHAPPEVLSTFAIDARMGSVVLRRPLDYEETHAYELDVQARDLGANPIPAHCKVLVRVLDVNDNAPDVRVTWAARAPVLSEAVPKDSFVALVTASDPDSGNNGRVHCSLSPGDEHFRLKQTNSHSYLLMTNAMLDRELRAEYNLTLVARDQGEHSLAVWKHLTICISDVNDNAPSFERTSYERAVEENGDVPAFLLTVRATDPDLGFNGKVTYSIRDSTVLGLVSIDPISGDITALRAFDHEQMSSLEFLVTAEDGGHPVLASNVTVRLEVLDQNDNAPVVTEPPLVRGMATLSVLVSAETGCVWVTSGNGSAMETVLANVSCSDTPLLFTIVARDGDSGRNGALRYDIMGGDAAGLVVLDPLSGQAFLNASNASRLAGTQQDLAVRISDGGDEPLHTQACVRLLFRQHGAFSKMSAGGPGWLSPPVVAAICLAALLGSCLLLSALTLSLRKKEKKDSMAYNCREAEDARRQQQLKKPPRQIQKADIHLVPTPWGRPRGAEPQQPSVEGSPQPPPLLTPTLYRTLRNQRVSRDSDEEQGMFTLPVVQRRPCPSHRPKNSPTDVVGNLPPEEPPLSAPQPRPPQHILRSLVRLSLVALAEQSPNGEFAMESAPVQQISQLLSLLHQGQFQPKTNHRGNKYTAKNGSRAAGLDADCLSTKDSGHGESEAEDRDSESGFELSVQQLVGEELETLLEPQAELALKRLTADPAWVARLSLPPTGNYKDNVFSPGSLHSSQDEEAVGREKPRTFETFGKGPGSDSNAAGTRLASTFLSEMSTLFEMILSQKVQVHNETGSGLLRQLSARGKSLGLDDSAPVL", "length": 1119 }, "evidence": [ { "id": "F1N0X0", "url": "https://omabrowser.org/oma/group/F1N0X0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F5T8-1", "protein_name": "Protocadherin-12", "gene_name": "pcdh12", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLQVLLLLAALFECQVCLANNMGSAHLTIQYRVWEEQPPGTRVGRLLDDLRERGETGSLENFQVVQHGHALPVTVASRDGTVSTFGRLDREELCWGTELCELAFNVLYRKGGAMHLLSVRVEVMDLNDHNPVFPSLLQEVEISETASLRMRIPLDRAADPDAGPNGLQTYTLSSNQHFALDVRSFGGAKQAELVVTKELDRELQASLELELIAWDKGNPPKSGSTKIIVTILDSNDNSPIFEEAPSVIELAENTIRGTIVLNLRATDPDQGANGEVEYSLSKHSPLEVQRLFSIHPKTGALTLQGPLDFEEKNVYEVDIQARDLGPNGIPSHHKLQIKLQDINDNAPRIHITWTPPDSPVATVTEGAPNETFLALVMVSDADYGANGQVQVHILTGSGPFRLKQIHGDNYMIVTNGTLDREKQMEYNLTLLAQDSGDPSLSCIKHLTVHVLDENDNPPIFTKSHYRSILKENNTPGFHFLTVEAHDVDLGLSGQVSFSIRESNELGTPTAFFSVHPSSGEVTVQQSLDYEESRVYSFIVEAVDQGYPPMTSIAAVLVEIQDVNDNYPIIYEPLPKKGIALLNVPVNVDKGEIVTELGDKAMEDNFHKHRNYSSLNKPEGFLATTIRASDPDSGLNGRLNFGITGGNPSNIFFLDKTSGEFYVNTTNATELIGRTFKLGIEVSDMGTPILSTRTTLEVTFINFRDHLKNLSHDNQAQYSFTMLLAICLGSTCLVLFLIIALAKTFCHPNKRDNRAYNCRQAESTYTRHPRRPQKHIQKTDIQLVPVLRGRRETSQEDEAEALSSTSPLVEKAHSQSQFTFTPTLARMTQNQAHTEMDGNLPLTQSKILKKPGSIEWNGTLPYTSGTPCRTLQKTRNSSSSSFANSQASTLRRNKIEESKPTSMDTSQTVTSVSSNQATLRRPKTTEKRGRMEESDQRQILRNLVRLSMAAFAENGSFELSSASPEVQQVSQLLSLLHQGQLQPRPNFRGNKYSHRAGRSGAQDADWLSTKDSGHGESEMGDMDWETGRDSPVDHLYEEGLNNLLTSDDVFSDVPDPAWMARLSLPLSTDYHENLFIPDGPPSPDALCTMSSLDDFTSFSTFGKTLESQPLGGRALMSEVSSLFEMLLTQKADAQSCPPADVLYRLSAAYGRSLGLDVPVNGGAVTSRQQAQTSIM", "length": 1174 }, "evidence": [ { "id": "F1N0X0", "url": "https://omabrowser.org/oma/group/F1N0X0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1MA46-1", "protein_name": "Protocadherin-12", "gene_name": "Pcdh12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TMLLLPFLLGLLGPGSYLFISGACQEVATVTVKFQVAEEVPSGTVIGKLSQEPGVEERRGKAGDAFQILQLPQALPIQMNSEDGLLNTSSRLDREKLCRQQDPCLVSFDVLATGASALIHVEIQVLDINDHQPQFPKDEQELEISESASLHTRIPLDRALDQDTGPNSLYSYSLSPSEHFALDVIVGPDETKHAELVVVKELDREVHSYFDLVLTAYDNGNPPKSGTSVVKVNVLDSNDNSPVFAESSLALEIPEDTAPGTLLINLTATDPDQGPNGEVEFFFGKHVSPEVMNTFGIDAKTGQIVLLQPLDYEKNPAYEVDVQARDLGPNSIPGHCKVLIKVLDVNDNAPSIHITWASQMSLVSEDLPRDSFIALVSANDLDSGNNGLVNCWLNQELGHFRLKRTNGNTYMLLTSAMLDREQWPTYTLTVFAQDQGPQALSAEKELQIQVSDVNDNAPVFEKSRYEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDSETGEVTAQRSLDYEEMAGFEFQVIAEDRGQPQLSSSISVWVSLLDANDNTPEVIQPALSEGKATLSVLVNASTGHLLLPIESPSGMDPAGTGPTPPKATHSPWSFLLVTIVARDADSGANGELLYSIQSGNDAHLFVLSPSLGQLFINVTNASSLIGSQWDLGIVVEDQGSPSLQTQVSLKVVFVTSMDHLRDSAHEPGILSTPALAMICLAVLLAVFGLILALLVSICRIEKRDNRAYNCREAESMYRHQPKRPQKHIQKADIHLVPMLRAQEDEAEEVRPPHKDTSKETLMEAGWDSCLQAPFHLTPTLYRTLRNQGNQGALAESQEVLQDTFNFLFNHPRQRNASRENLNLPESPPTLRQPLLKPLKVPGSPIARVTGDQGSKEAPQSPPASSATLRRQRNLNGKVSPKGESSPHQILRSLVRLSVAAFAERNPVEELAGDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYSAKPGSSRATIPDTDGLGIRPGGLSEPDLEEGPPSPEEDLSVKRLLEEELSSLLDPNTGLALDKLSPPDPAWMARLSLPLTTNYRDNLSSPDAAASEEPRTFQTFGKTVGPGPELSATGTRLASTFVSEMSSLLEMLLEQNTVPVEAASAALRRLSVCGRTLSLDLATSGASGSEAQLGRKKAAESSLGCGRNL", "length": 1180 }, "evidence": [ { "id": "F1N0X0", "url": "https://omabrowser.org/oma/group/F1N0X0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RM49-1", "protein_name": "Protocadherin-12", "gene_name": "PCDH12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMPLLPLLLGLLGPGGSLLLSGDCQEVATLTVKYQVSEEVPAGTVIGKLARELGREERPGLAGGAFQVLQLPQALPIQVDAEDGLLSTGKRLDREQLCRQQDPCLVSFDVLAAGDLALIHVEVQVLDINDHQPQFPKGEQELEISESASLSTRIPLDRALDPDTGPNTLHSYTLSPSEHFALDVIVGPDETKHAELVVVKELDREIRSFFDLVLTAYDSGNPPKSGTSLVKVNVLDSNDNSPVFAESSLALEVQEDTAPGTLLINLTATDPDQGPNGEVEFLLSKHVPPEVLDAFSIDAKTGQVILRQPLDYEKNPAYEVDVQARDLGPNPIPAHCKILIKVLDVNDNAPSIHITWASQPSLVSEALPKDSFVALVTANDLDSGDNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPLYTLTLLAQDRGPQPLSAETLLSIQISDANDNAPVFEKSRYQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVSHLVAIDPDTGDVTAQRSLDYEQMAGFEFLVVAEDGGQPQLASSVSVWVSILDANDNAPEVIHPMLSDGKASLSVLVNASTGHLLVPIETPNGPGPAGTNSPPQAAPGSQPFFLATIVARDADSGPNGELLYSIRSGNEACLFVLSPRLGQLFVNTTNASSLIGSAWELEIAVQDGGSPSLQTRALLRVVFVTSADHLRDSAREPGALSTSMLAVICLAVLLAVFGSVLALIMSICRTEKKDHRAYNCREAESSYRHQPKRPQKHIQKADIHLVPVLRGQGEETGDVGPPPKHVSSETSLEAGWDPCLQAPFHLTPTLYRTLRNQGNEGAQAESREVLQDTVNLLFNHPRQRNASRENLNLPEPQAAVGQPRSRPLKVPGSPPGRAPGDQGGPEAPLSPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGSGRSAIPEPDGPGARAGGQAEPDQEEGLLDPEEDLSVKQLLEEELSSLLDPHTGLTLDRLSVPDPAWMARLSLPLASNYRDNVFSPDAAASEEPRTFQTFGKAPGPELSPTGTRLASTFLSEMSSLLEMLLEQRSAVPVEAASEVLRRLSVCGRTLSLDLATSGASGSEVPGGPAGKKGAEARTNSSSSSSRDLWIQEPGAPGDVRKPTP", "length": 1200 }, "evidence": [ { "id": "F1N0X0", "url": "https://omabrowser.org/oma/group/F1N0X0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O55134-1", "protein_name": "Protocadherin-12", "gene_name": "Pcdh12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMLLLPFLLGLLGPGSYLFISGDCQEVATVMVKFQVTEEVPSGTVIGKLSQELRVEERRGKAGDAFQILQLPQALPVQMNSEDGLLSTSSRLDREKLCRQEDPCLVSFDVLATGASALIHVEIQVLDINDHQPQFPKDEQELEISESASLHTRIPLDRALDQDTGPNSLYSYSLSPSEHFALDVIVGPDETKHAELVVVKELDRELHSYFDLVLTAYDNGNPPKSGISVVKVNVLDSNDNSPVFAESSLALEIPEDTVPGTLLINLTATDPDQGPNGEVEFFFGKHVSPEVMNTFGIDAKTGQIILRQALDYEKNPAYEVDVQARDLGPNSIPGHCKVLIKVLDVNDNAPSILITWASQTSLVSEDLPRDSFIALVSANDLDSGNNGLVHCWLNQELGHFRLKRTNGNTYMLLTNATLDREQWPIYTLTVFAQDQGPQPLSAEKELQIQVSDVNDNAPVFEKSRYEVSTWENNPPSLHLITLKAHDADLGSNGKVSYRIKDSPVSHLVIIDFETGEVTAQRSLDYEQMAGFEFQVIAEDRGQPQLASSISVWVSLLDANDNAPEVIQPVLSEGKATLSVLVNASTGHLLLPIENPSGMDPAGTGIPPKATHSPWSFLLLTIVARDADSGANGELFYSIQSGNDAHLFFLSPSLGQLFINVTNASSLIGSQWDLGIVVEDQGSPSLQTQVSLKVVFVTSVDHLRDSAHEPGVLSTPALALICLAVLLAIFGLLLALFVSICRTERKDNRAYNCREAESSYRHQPKRPQKHIQKADIHLVPVLRAHENETDEVRPSHKDTSKETLMEAGWDSCLQAPFHLTPTLYRTLRNQGNQGELAESQEVLQDTFNFLFNHPRQRNASRENLNLPESPPAVRQPLLRPLKVPGSPIARATGDQDKEEAPQSPPASSATLRRQRNFNGKVSPRGESGPHQILRSLVRLSVAAFAERNPVEEPAGDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGGSSRGTIPDTEGLVGLKPSGQAEPDLEEGPPSPEEDLSVKRLLEEELSSLLDPNTGLALDKLSPPDPAWMARLSLPLTTNYRDNLSSPDATTSEEPRTFQTFGKTVGPGPELSPTGTRLASTFVSEMSSLLEMLLGQHTVPVEAASAALRRLSVCGRTLSLDLATSGASASEAQGRKKAAESRLGCGRNL", "length": 1180 }, "evidence": [ { "id": "F1N0X0", "url": "https://omabrowser.org/oma/group/F1N0X0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPG4-1", "protein_name": "Protocadherin-12", "gene_name": "PCDH12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMQLLQLLLGLLGPGGYLFLLGDCQEVTTLTVKYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGALSMSMLTVICLAVLLGIFGLILALFMSICRTEKKDNRAYNCREAESTYRQQPKRPQKHIQKADIHLVPVLRGQAGEPCEVGQSHKDVDKEAMMEAGWDPCLQAPFHLTPTLYRTLRNQGNQGAPAESREVLQDTVNLLFNHPRQRNASRENLNLPEPQPATGQPRSRPLKVAGSPTGRLAGDQGSEEAPQRPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQQISQLLSLLHQGQFQPKPNHRGNKYLAKPGGSRSAIPDTDGPSARAGGQTDPEQEEGPLDPEEDLSVKQLLEEELSSLLDPSTGLALDRLSAPDPAWMARLSLPLTTNYRDNVISPDAAATEEPRTFQTFGKAEAPELSPTGTRLASTFVSEMSSLLEMLLEQRSSMPVEAASEALRRLSVCGRTLSLDLATSAASGMKVQGDPGGKTGTEGKSRGSSSSSRCL", "length": 1184 }, "evidence": [ { "id": "F1N0X0", "url": "https://omabrowser.org/oma/group/F1N0X0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" }, { "name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "database": "UniProtKB", "id": "F1N0X0", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 856, "end_pos": 858, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0X0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0X0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0X0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X0" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 134, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 264, "end_pos": 266 }, { "start_pos": 414, "end_pos": 416 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 658, "end_pos": 660 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 856, "end_pos": 858 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0X1-1", "uniprot_ac": "F1N0X1", "uniprot_id": "F1N0X1_BOVIN", "mass": { "chemical_mass": 56787.0, "monoisotopic_mass": 56787.0 }, "refseq": {}, "gene_names": [ { "name": "DELE1", "type": "recommended", "evidence": [ { "id": "F1N0X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ] } ], "protein_names": [ { "name": "DAP3-binding cell death enhancer 1", "type": "recommended", "evidence": [ { "id": "F1N0X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X1/entry#names_and_taxonomy" } ] }, { "name": "DAP3-binding cell death enhancer 1, long form", "type": "synonym", "evidence": [ { "id": "F1N0X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X1/entry#names_and_taxonomy" } ] }, { "name": "Death ligand signal enhancer", "type": "synonym", "evidence": [ { "id": "F1N0X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR. Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy.", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1#function" }, { "database": "UniProtKB", "id": "ARBA00057911", "url": "https://www.uniprot.org/uniprotkb/ARBA00057911#function" } ] }, { "annotation": "Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR.", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1#function" }, { "database": "UniProtKB", "id": "ARBA00059730", "url": "https://www.uniprot.org/uniprotkb/ARBA00059730#function" } ] }, { "annotation": "Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1#function" }, { "database": "UniProtKB", "id": "ARBA00057153", "url": "https://www.uniprot.org/uniprotkb/ARBA00057153#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DELE1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1", "locus": { "chromosome": "7", "start_pos": 53004020, "end_pos": 52989035, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008435", "url": "https://www.ensembl.org/id/ENSBTAG00000008435" } ] } } ], "crossref": [ { "id": "F1N0X1", "url": "https://alphafold.ebi.ac.uk/entry/F1N0X1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008435", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008435", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HAWSTGN", "url": "https://omabrowser.org/oma/group/HAWSTGN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0X1", "url": "https://www.orthodb.org/?gene=F1N0X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45011:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45011:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840373", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0X1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWRLPGLLGRALPRLLGPGLRGVTPKSSSPDGPQATSSNLLVPVPSFDRSSPHCPGPGTSRGPKSHGWKDAFQWMSARGSRNTLWDAISWGTLAVLALQLARQIHFQTSLPAGPWRVEHCSWCSPLDRFLSSPLRHPCSSLRRHILPSPDSPAPRHTDLGECRLGQDESSTQPKSVASPSSLRAARHQDPSEEDPSDISFLHASSSFKSKAKPAQPQPTDEKQEQEKSKSLSLEEAMTSIQQLFQLSVSIAFNFLGTENMKNGDYMAAFSYFQKAADRGYSKAQYNVGLCHEHGRGTPRDPSKAAFYYQLAASQGHNLAQYRYARCLLQDPGSSWDPERQRAVSMLKRAADSGLREAQAFLGVLFTKEPYVDERRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQKSLGEAMRCYQQSAALGNTPAQERLRALFSTEAAAPGPSDLAVRGLKSFSSPSLCSLNRNLLAGASCLPHASSTGNLGLLCRSGHLRTSPGAPSRAIPQHPYPLERSLVRLGFG", "length": 520, "header": "tr|F1N0X1-1|F1N0X1_BOVIN Isoform 1 of DAP3-binding cell death enhancer 1 OS=Bos taurus OX=9913 GN=DELE1 PE=3 SV=1 CANONICAL=F1N0X1-1" }, "isoforms": [ { "isoform_ac": "F1N0X1-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1/entry", "sequence": { "sequence": "MWRLPGLLGRALPRLLGPGLRGVTPKSSSPDGPQATSSNLLVPVPSFDRSSPHCPGPGTSRGPKSHGWKDAFQWMSARGSRNTLWDAISWGTLAVLALQLARQIHFQTSLPAGPWRVEHCSWCSPLDRFLSSPLRHPCSSLRRHILPSPDSPAPRHTDLGECRLGQDESSTQPKSVASPSSLRAARHQDPSEEDPSDISFLHASSSFKSKAKPAQPQPTDEKQEQEKSKSLSLEEAMTSIQQLFQLSVSIAFNFLGTENMKNGDYMAAFSYFQKAADRGYSKAQYNVGLCHEHGRGTPRDPSKAAFYYQLAASQGHNLAQYRYARCLLQDPGSSWDPERQRAVSMLKRAADSGLREAQAFLGVLFTKEPYVDERRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQKSLGEAMRCYQQSAALGNTPAQERLRALFSTEAAAPGPSDLAVRGLKSFSSPSLCSLNRNLLAGASCLPHASSTGNLGLLCRSGHLRTSPGAPSRAIPQHPYPLERSLVRLGFG", "length": 520, "header": "tr|F1N0X1-1|F1N0X1_BOVIN Isoform 1 of DAP3-binding cell death enhancer 1 OS=Bos taurus OX=9913 GN=DELE1 PE=3 SV=1 CANONICAL=F1N0X1-1" }, "locus": { "chromosome": "7", "start_pos": 53002707, "end_pos": 52989437, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011098.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011098.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011098.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011098.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9840373", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840373", "resource": "Reactome", "description": "Cellular response to mitochondrial stress" } ], "orthologs": [ { "uniprot_canonical_ac": "P60924-1", "protein_name": "DAP3-binding cell death enhancer 1", "gene_name": "Dele1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWRLTGILGRALPRLLGPGFRGITPKPTSSDGPQTTSTTLPLPRVNFDRSGSHGSKRNRDPKCCGWKEAFHWMSAHVSPNTLRDAVSWGTLAVLALHLARQIHFHAPLVAGPQSAERCSWHSPLYRFLSSSWWHPHSSLRRHVLPSPDCPAPRNTGLREPRLGQEEPAARSQGLPSDSSLKPGLLNLPEEEPSDFGFLNASRDFTSQAKAAEAGPPGGKNEQDKPKALPLEEAVTSIQQLFQLSVAIAFNFLGTENIKTGDYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTPRDLSKAVLFYHLAAVQGHSLAQYRYARCLLQSPGSMSDPERQRAVSLLKQAADSGLTEAQAFLGVLFTKEPHLDEQKAVKYFWLAASNGDSQSRFHLGICYEKGLGVQRNLGEAVKCYQKSAAMGNEPAQERLRTLFNVEAAGPSHLAIGLKSFSSPSLCSLNTFLAGASGLPHASSTGNLGLLCRSGHLGTSHGAPSRAMPSLERSLVRLGFG", "length": 509 }, "evidence": [ { "id": "F1N0X1", "url": "https://omabrowser.org/oma/group/F1N0X1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14154-1", "protein_name": "DAP3-binding cell death enhancer 1", "gene_name": "DELE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWRLPGLLGRALPRTLGPSLWRVTPKSTSPDGPQTTSSTLLVPVPNLDRSGPHGPGTSGGPRSHGWKDAFQWMSSRVSPNTLWDAISWGTLAVLALQLARQIHFQASLPAGPQRVEHCSWHSPLDRFFSSPLWHPCSSLRQHILPSPDGPAPRHTGLREPRLGQEEASAQPRNFSHNSLRGARPQDPSEEGPGDFGFLHASSSIESEAKPAQPQPTGEKEQDKSKTLSLEEAVTSIQQLFQLSVSIAFNFLGTENMKSGDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPERQRAVSLLKQAADSGLREAQAFLGVLFTKEPYLDEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGNEAAQERLRALFSMGAAAPGPSDLTVTGLKSFSSPSLCSLNTLLAGTSRLPHASSTGNLGLLCRSGHLGASLEASSRAIPPHPYPLERSVVRLGFG", "length": 515 }, "evidence": [ { "id": "F1N0X1", "url": "https://omabrowser.org/oma/group/F1N0X1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCV6-1", "protein_name": "DAP3-binding cell death enhancer 1", "gene_name": "Dele1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRLTGILGRALPRLLGPGFRGITPKPTSSDGSQTTSPTLPLTRLSFDRSGSHGSKRSRDPKCCGWKDAFHWMSAHVSPNTLRDAISWGTLAVLALHLARQIHFHAPLVAGPQPAERSWHSPLYRFLSSSWWHPHSSLRRHVLPRSDCPAPRNTGLREPRQGQEDHPSAPSQCLPSDSSLRSGLLNLPEEEPSDFDFLHASRDFASQAKAAEAHPPGGKNEQDKAKALPLEEAVTSIQQLFQLSVAITFNFLGTENIKTGDYTAAFSYFQKAADRGYSKAQYNVGLCLEHGRGTPRDLSKAILFYHLAAVQGHSLAQYRYARCLLQSPGSLSDPERERAVSLLKQAADSGLTEAQAFLGVLFTKEPHLDEQRAVKYLWLAASNGDSQSRFHLGICYEKGLGAQRNLGEAVKCYQQAAAMGNEPARERLRTLFNVEAAGPSHLATTGLKSFSSPSLCSLNTLLAGASGLPHASSTGNLGLLCRSGHLGASHGAPSRTIPSLERSLVRLGFG", "length": 510 }, "evidence": [ { "id": "F1N0X1", "url": "https://omabrowser.org/oma/group/F1N0X1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of mitophagy", "id": "GO:1901526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901526", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:0008625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008625", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "response to iron ion starvation", "id": "GO:1990641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990641", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "HRI-mediated signaling", "id": "GO:0140468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140468", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "F1N0X1", "url": "https://www.uniprot.org/uniprotkb/F1N0X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0X1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 520, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0X1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0X1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0X3-1", "uniprot_ac": "F1N0X3", "uniprot_id": "F1N0X3_BOVIN", "mass": { "chemical_mass": 59435.0, "monoisotopic_mass": 59435.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100138271", "type": "recommended", "evidence": [ { "id": "F1N0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ] } ], "protein_names": [ { "name": "Oviduct-specific glycoprotein", "type": "recommended", "evidence": [ { "id": "F1N0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X3/entry#names_and_taxonomy" } ] }, { "name": "Estrogen-dependent oviduct protein", "type": "synonym", "evidence": [ { "id": "F1N0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X3/entry#names_and_taxonomy" } ] }, { "name": "Oviductal glycoprotein", "type": "synonym", "evidence": [ { "id": "F1N0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X3/entry#names_and_taxonomy" } ] }, { "name": "Oviductin", "type": "synonym", "evidence": [ { "id": "F1N0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100138271", "url": "https://www.uniprot.org/uniprotkb/F1N0X3", "locus": {} } ], "crossref": [ { "id": "F1N0X3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0X3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005973", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005973", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000024849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02872", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02872", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FFQYPTF", "url": "https://omabrowser.org/oma/group/FFQYPTF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M079", "url": "https://www.orthodb.org/?gene=A0A3Q1M079", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11177:SF385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11177:SF385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M079", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M079", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M079-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M079-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0X3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VFLPSSPAGLLLVLKHHDGAAHKLVCYFTNWAFSRPGPASILPRDLDPFLCTHLVFAFASMNNNQIVPKDPLDEKILYPEFNKLKESNRGLKTLLSTGGWNFGTSRFTTMLSMFSNRERFVSSVIALLRTHGFDGLDLFFLYPGLRGSPARDRWTFVSLLEELLQAFKNEAQLTMRPRLLLSAAVSGDPHVVQKAYEARLLGRLLDFISILSYDLHGSWEKVTGHNSPLFSLPGDPKSSAYAMNYWRQLGVPPEKLLMGLPTYGHTFHLLKASQNELRAQAVGPASPGKYTKQAGFLAYYEICSFIEGMNKCWIDDQYVPYAFKGKEWVGYDDAISFSYKAFFIKREHFGGAMVWTLDLDDVTGAFCGTGPFPLVYTLNYLLVKDEFSSTPSPKLWFSTAVNSSIGPEMPTMTRDLTTSLGILPPGGEAVATETKGKSAAMATTPRSEIMTPTRTPMTFERHTAAPEGKTESPGEKPVLPVGHLVGSPGGIAMDPVHLQIGQKVTPPGRKAGVPEKVTTPSGKMTVTPDGRAETLERRL", "length": 539, "header": "tr|F1N0X3-1|F1N0X3_BOVIN Isoform 1 of Oviduct-specific glycoprotein OS=Bos taurus OX=9913 GN=LOC100138271 PE=3 SV=4 CANONICAL=F1N0X3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M079-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M079/entry", "sequence": { "sequence": "VFLPSSPAGLLLVLKHHDGAAHKLVCYFTNWAFSRPGPASILPRDLDPFLCTHLVFAFASMNNNQIVPKDPLDEKILYPEFNKLKESNRGLKTLLSTGGWNFGTSRFTTMLSMFSNRERFVSSVIALLRTHGFDGLDLFFLYPGLRGSPARDRWTFVSLLEELLQAFKNEAQLTMRPRLLLSAAVSGDPHVVQKAYEARLLGRLLDFISILSYDLHGSWEKVTGHNSPLFSLPGDPKSSAYAMNYWRQLGVPPEKLLMGLPTYGHTFHLLKASQNELRAQAVGPASPGKYTKQAGFLAYYEICSFIEGMNKCWIDDQYVPYAFKGKEWVGYDDAISFSYKAFFIKREHFGGAMVWTLDLDDVTGAFCGTGPFPLVYTLNYLLVKDEFSSTPSPKLWFSTAVNSSIGPEMPTMTRDLTTSLGILPPGGEAVATETKGKSIMTPTRTPMTFERHTAAPEGKTESPGEKPVLPVGHLVGSPGGIAMDPVHLQIGQKVTPPGRKAGVPEKVTTPSGKMTVTPDGRAETLERRL", "length": 529, "header": "tr|A0A3Q1M079-1|A0A3Q1M079_BOVIN Computationally mapped isoform of Oviduct-specific glycoprotein OS=Bos taurus OX=9913 GN=LOC100138271 PE=3 SV=3 CANONICAL=F1N0X3-1" }, "locus": { "chromosome": "3", "start_pos": 31984305, "end_pos": 31973855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079939.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079939.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063026.3", "url": "https://www.ensembl.org/id/ENSBTAP00000063026.3" } ] } }, { "isoform_ac": "F1N0X3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X3/entry", "sequence": { "sequence": "VFLPSSPAGLLLVLKHHDGAAHKLVCYFTNWAFSRPGPASILPRDLDPFLCTHLVFAFASMNNNQIVPKDPLDEKILYPEFNKLKESNRGLKTLLSTGGWNFGTSRFTTMLSMFSNRERFVSSVIALLRTHGFDGLDLFFLYPGLRGSPARDRWTFVSLLEELLQAFKNEAQLTMRPRLLLSAAVSGDPHVVQKAYEARLLGRLLDFISILSYDLHGSWEKVTGHNSPLFSLPGDPKSSAYAMNYWRQLGVPPEKLLMGLPTYGHTFHLLKASQNELRAQAVGPASPGKYTKQAGFLAYYEICSFIEGMNKCWIDDQYVPYAFKGKEWVGYDDAISFSYKAFFIKREHFGGAMVWTLDLDDVTGAFCGTGPFPLVYTLNYLLVKDEFSSTPSPKLWFSTAVNSSIGPEMPTMTRDLTTSLGILPPGGEAVATETKGKSAAMATTPRSEIMTPTRTPMTFERHTAAPEGKTESPGEKPVLPVGHLVGSPGGIAMDPVHLQIGQKVTPPGRKAGVPEKVTTPSGKMTVTPDGRAETLERRL", "length": 539, "header": "tr|F1N0X3-1|F1N0X3_BOVIN Isoform 1 of Oviduct-specific glycoprotein OS=Bos taurus OX=9913 GN=LOC100138271 PE=3 SV=4 CANONICAL=F1N0X3-1" }, "locus": { "chromosome": "3", "start_pos": 31984305, "end_pos": 31973855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007838.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007838.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007838.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007838.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" }, { "name": "chitin catabolic process", "id": "GO:0006032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chitinase activity", "id": "GO:0004568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004568", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" }, { "name": "chitin binding", "id": "GO:0008061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "database": "UniProtKB", "id": "F1N0X3", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0X3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 539, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0X3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0X3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X3" }, { "id": "PS51910", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51910" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GH18", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 385, "start_aa": "His", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 402, "end_pos": 404 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0X9-1", "uniprot_ac": "F1N0X9", "uniprot_id": "F1N0X9_BOVIN", "mass": { "chemical_mass": 28424.0, "monoisotopic_mass": 28424.0 }, "refseq": { "ac": "NP_001012693", "name": "major histocompatibility complex, class II, DQ alpha 5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012693" }, "gene_names": [ { "name": "BOLA-DQA2", "type": "recommended", "evidence": [ { "id": "F1N0X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ] }, { "name": "BOLA-DQA5", "type": "synonym", "evidence": [ { "id": "NP_001012693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012693" } ] }, { "name": "BoLA-DQA", "type": "synonym", "evidence": [ { "id": "NP_001012693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012693" } ] } ], "protein_names": [ { "name": "MHC class II antigen", "type": "synonym", "evidence": [ { "id": "NP_001012693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012693" } ] }, { "name": "Major histocompatibility complex, class II, DQ alpha 5", "type": "synonym", "evidence": [ { "id": "F1N0X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X9/entry#names_and_taxonomy" } ] }, { "name": "major histocompatibility complex, class II, DQ alpha 5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001012693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012693" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BOLA-DQA2", "url": "https://www.uniprot.org/uniprotkb/F1N0X9", "locus": {} } ], "crossref": [ { "id": "F1N0X9", "url": "https://alphafold.ebi.ac.uk/entry/F1N0X9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009656", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009656", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000038128", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038128", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21008", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21008", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282494", "url": "https://www.ncbi.nlm.nih.gov/gene/282494", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282494", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282494", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFYPPDI", "url": "https://omabrowser.org/oma/group/YFYPPDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BLZ1", "url": "https://www.orthodb.org/?gene=E1BLZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0X9", "url": "https://www.orthodb.org/?gene=F1N0X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00993", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00993", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-202424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202427", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202427", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202433", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202433", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389948", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389948", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001012693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BLZ1", "url": "https://www.uniprot.org/uniprotkb/E1BLZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BLZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0X9-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLNRALILGTLALTTMMSPSGGEDIVADHVGIYGVNIYQSYGPSGQFTHEFDGDEQFYVDLEKKETVWKLPLFSRMLSFDPQFALRNIAIMKLHVDFLTKFSNSTAATNKVPEVTVFSKSPVMLGQPNTLICHVDNIFPPVINITWLRNGHSVTEGVSETSFLIKSDYSFLKIKYLTFLPSDDDIYDCKVEHWGLDEPLLKHWEPEIPAPMSELTETVVCTLGLTVGLVGIMVGTIFIIQGLRSGDPSRHQGPL", "length": 255, "header": "tr|F1N0X9-1|F1N0X9_BOVIN Isoform 1 of Major histocompatibility complex, class II, DQ alpha 5 OS=Bos taurus OX=9913 GN=BOLA-DQA2 PE=3 SV=1 CANONICAL=F1N0X9-1" }, "isoforms": [ { "isoform_ac": "E1BLZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BLZ1/entry", "sequence": { "sequence": "MVLNRALILGTLALTTMMSPSGGEDIVADHVGSYGTEIYQSHGPSGQYTQEFDGDELFYVDLGKKETVWRLPMFSQFAGFDPQAALSEIATAKHNLDVLTKRSNFTPVINEVPEVTVFSKSPMVLGQPNTLICHMDNFPPVINITWLKNGHAVTEGVSETSFLPKDDHSFLKIGYLTFLPSDDDVYDCKVEHWSLDEPLLKHWEPEVPAPMSELTETVVCALRLTVGLVGIVVGTIFIIQGLRSGGASRHQGPL", "length": 254, "header": "tr|E1BLZ1-1|E1BLZ1_BOVIN Computationally mapped isoform of Major histocompatibility complex, class II, DQ alpha 5 OS=Bos taurus OX=9913 GN=BOLA-DQA2 PE=3 SV=4 CANONICAL=F1N0X9-1" }, "locus": { "chromosome": "23", "start_pos": 25643813, "end_pos": 25583528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034283.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034283.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034180.6", "url": "https://www.ensembl.org/id/ENSBTAP00000034180.6" } ] } }, { "isoform_ac": "F1N0X9-1", "url": "https://www.uniprot.org/uniprotkb/F1N0X9/entry", "sequence": { "sequence": "MVLNRALILGTLALTTMMSPSGGEDIVADHVGIYGVNIYQSYGPSGQFTHEFDGDEQFYVDLEKKETVWKLPLFSRMLSFDPQFALRNIAIMKLHVDFLTKFSNSTAATNKVPEVTVFSKSPVMLGQPNTLICHVDNIFPPVINITWLRNGHSVTEGVSETSFLIKSDYSFLKIKYLTFLPSDDDIYDCKVEHWGLDEPLLKHWEPEIPAPMSELTETVVCTLGLTVGLVGIMVGTIFIIQGLRSGDPSRHQGPL", "length": 255, "header": "tr|F1N0X9-1|F1N0X9_BOVIN Isoform 1 of Major histocompatibility complex, class II, DQ alpha 5 OS=Bos taurus OX=9913 GN=BOLA-DQA2 PE=3 SV=1 CANONICAL=F1N0X9-1" }, "locus": { "chromosome": "23", "start_pos": 25643813, "end_pos": 25637351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019800.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019800.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019800.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019800.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282494", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282494", "resource": "KEGG Pathway" }, { "id": "R-BTA-202424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "resource": "Reactome", "description": "Downstream TCR signaling" }, { "id": "R-BTA-202427", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202427", "resource": "Reactome", "description": "Phosphorylation of CD3 and TCR zeta chains" }, { "id": "R-BTA-202430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202430", "resource": "Reactome", "description": "Translocation of ZAP-70 to Immunological synapse" }, { "id": "R-BTA-202433", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202433", "resource": "Reactome", "description": "Generation of second messenger molecules" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-389948", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389948", "resource": "Reactome", "description": "Co-inhibition by PD-1" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "MHC class II protein complex", "id": "GO:0042613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042613", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "antigen processing and presentation of exogenous peptide antigen via MHC class II", "id": "GO:0019886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019886", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "peptide antigen assembly with MHC class II protein complex", "id": "GO:0002503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002503", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "positive regulation of T cell activation", "id": "GO:0050870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050870", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "positive regulation of immune response", "id": "GO:0050778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050778", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "MHC class II protein complex binding", "id": "GO:0023026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023026", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" }, { "name": "peptide antigen binding", "id": "GO:0042605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042605", "evidence": [ { "database": "UniProtKB", "id": "F1N0X9", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0X9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 255, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0X9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0X9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0X9" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 193, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 144, "end_pos": 146 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Y0-1", "uniprot_ac": "F1N0Y0", "uniprot_id": "F1N0Y0_BOVIN", "mass": { "chemical_mass": 52584.0, "monoisotopic_mass": 52584.0 }, "refseq": {}, "gene_names": [ { "name": "UPP1", "type": "recommended", "evidence": [ { "id": "F1N0Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ] } ], "protein_names": [ { "name": "Uridine phosphorylase", "type": "recommended", "evidence": [ { "id": "F1N0Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0/entry#names_and_taxonomy" } ] }, { "name": "2.4.2.3", "type": "synonym", "evidence": [ { "id": "F1N0Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0#function" }, { "database": "UniProtKB", "id": "RU361131", "url": "https://www.uniprot.org/uniprotkb/RU361131#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UPP1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0", "locus": { "chromosome": "4", "start_pos": 7619658, "end_pos": 7648284, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008428", "url": "https://www.ensembl.org/id/ENSBTAG00000008428" } ] } } ], "crossref": [ { "id": "F1N0Y0", "url": "https://alphafold.ebi.ac.uk/entry/F1N0Y0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008428", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008428", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17763", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17763", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HPNICAG", "url": "https://omabrowser.org/oma/group/HPNICAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0Y0", "url": "https://www.orthodb.org/?gene=F1N0Y0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43691", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43691", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43691:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43691:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-73614", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73614", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73621", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73621", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "24388", "url": "https://www.rhea-db.org/rhea/24388", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Y0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHFLPPSRALLGPGESQSEPGPERPRGPPLACGAHSHPQPNASSTPVTLALAPDNPPAPRLHSGWVPADTLAPAGAVTSGGHLCPLSLCCQEGKKPQGGVVGGTSGLMSKRLVSGHSPSPAAQQETRRGWGGGAGMGGAAGRRAGTPGRPDSTSSPVPPGTGRAVSARGASVAGVQFSGITLPGPASAEGMASTAAETEKPEDHNDLVQLCNPHIAAMKEDILYHFSLSTSTHDFPAMFGDVKFVCVGGSPSRMKAFIKYVAMELGFAHPGADYPNICEGTDRYAMFKVGPVLSVSHGMGVPSIAIMLHELIKLLYHARCSGVTLIRIGTSGGIGLEPGSVVITRQAVDPCFKPEFEQIVLGKREVRNTDLDEQLVQELARCSAELGEFPTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQEYLRAAYAAGIRNIEMEASVFAAMCNACGLRAAVVCVTLLNRLEGDQISSPHEVLAEYQQRPQRLVGQFIKKRLMQA", "length": 500, "header": "tr|F1N0Y0-1|F1N0Y0_BOVIN Isoform 1 of Uridine phosphorylase OS=Bos taurus OX=9913 GN=UPP1 PE=1 SV=2 CANONICAL=F1N0Y0-1" }, "isoforms": [ { "isoform_ac": "F1N0Y0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0/entry", "sequence": { "sequence": "MSHFLPPSRALLGPGESQSEPGPERPRGPPLACGAHSHPQPNASSTPVTLALAPDNPPAPRLHSGWVPADTLAPAGAVTSGGHLCPLSLCCQEGKKPQGGVVGGTSGLMSKRLVSGHSPSPAAQQETRRGWGGGAGMGGAAGRRAGTPGRPDSTSSPVPPGTGRAVSARGASVAGVQFSGITLPGPASAEGMASTAAETEKPEDHNDLVQLCNPHIAAMKEDILYHFSLSTSTHDFPAMFGDVKFVCVGGSPSRMKAFIKYVAMELGFAHPGADYPNICEGTDRYAMFKVGPVLSVSHGMGVPSIAIMLHELIKLLYHARCSGVTLIRIGTSGGIGLEPGSVVITRQAVDPCFKPEFEQIVLGKREVRNTDLDEQLVQELARCSAELGEFPTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQEYLRAAYAAGIRNIEMEASVFAAMCNACGLRAAVVCVTLLNRLEGDQISSPHEVLAEYQQRPQRLVGQFIKKRLMQA", "length": 500, "header": "tr|F1N0Y0-1|F1N0Y0_BOVIN Isoform 1 of Uridine phosphorylase OS=Bos taurus OX=9913 GN=UPP1 PE=1 SV=2 CANONICAL=F1N0Y0-1" }, "locus": { "chromosome": "4", "start_pos": 7648085, "end_pos": 7619718, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011088.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011088.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011088.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011088.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 105, "start_aa": "Thr", "end_pos": 105, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr105", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-73614", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73614", "resource": "Reactome", "description": "Pyrimidine salvage" }, { "id": "R-BTA-73621", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73621", "resource": "Reactome", "description": "Pyrimidine catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U3H6-1", "protein_name": "Uridine phosphorylase", "gene_name": "UPP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASAGAETKKLGNDNDFVRLSNPHLATMKEDVLYHFSLSTGTHDFPAMFGDVKFVCVGGSPSRMKAFIQYVAVELGLDVPGADYPNICVGTDRYAMFKVGPVLSVSHGMGIPSIAIMLHELIKLLYHARCSGVTIIRIGTSGGIGLEPGSVVITRQAVDPCFKPEFEQVVLGKRVVRSTHLDEPLMEELAQCSADLGEFPTVVGNTMCTLDFYEGQGRLDGALCSYAEKDKREYLNAAHAAGVRNIEMESSVFAAMCNACGLRAAVVCVTLLNRLEGDQISSPHEVLVEYQQRPQRLVGHFIKKRLSAA", "length": 309 }, "evidence": [ { "id": "F1N0Y0", "url": "https://omabrowser.org/oma/group/F1N0Y0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LQS1-1", "protein_name": "Uridine phosphorylase", "gene_name": "Upp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAATGTEAKDLENHHNDCFVQVSNPNIATMKEDVLYHFNLSTSTHDFPAMFGDVKFVCVGGSPSRMSTFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKVGPVLSVSHGMGIPSIGIMLHELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAVDECFKPEFEQIVLGKRVVRSTNLDVKLVQELMQCSSDLNEFPTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLQAAHAAGVRNIEMESSLFATMCSACGLRAAVVCVTLLDRLQGDQINTPHDVLVEYQQRPQRLVGHFIKKSLGKA", "length": 311 }, "evidence": [ { "id": "F1N0Y0", "url": "https://omabrowser.org/oma/group/F1N0Y0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0X899-1", "protein_name": "Uridine phosphorylase", "gene_name": "UPP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVMGQTGFSNIVDIEKRFKIHQKIVSSPKVQAYMAPGVSNEKKREDEQSSRENSIHLCNPHLEKMKEDILYHFALGTGTHDFPALFGDVKFVCVGGSPSRMKAFIAYIAEELGLGSSGGDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYHAKCSNITIIRIGTSGGIGLEPGSVVITRQSVDATFKPQFEQVVLGKTIIRSTNLDEELAKELLQCSKEINQFNTVIGNTMCTLDFYEGQGRLDGAICLYNEEEKLQYLKEAYDSGVRNIEMESSVFAAMCNLSGVRAAVVCVTLLNRLEGDQISSSHDILVEYQQRPQKLVGYFIKKSLGKV", "length": 346 }, "evidence": [ { "id": "F1N0Y0", "url": "https://omabrowser.org/oma/group/F1N0Y0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7F0D5-1", "protein_name": "Uridine phosphorylase", "gene_name": "Upp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATGTEAKDLENHHNSDCLVQLSNPNIATMKEDVLYHFNLSTSTHDFPAMFGDVKFVCVGGSSSRMSAFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKAGPVLSVSHGMGIPSIGIMLHELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAVDECFKPEFEQIVLGKRVTRNTSLDAQLVQELMQCSSDLNEFPTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLRAAHAAGVRNIEMESSVFATMCSACGLKAAVVCVTLLDRLQGDQINTPHNVLVEYQQRPQRLVGHFIKKRLGRA", "length": 312 }, "evidence": [ { "id": "F1N0Y0", "url": "https://omabrowser.org/oma/group/F1N0Y0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P52624-1", "protein_name": "Uridine phosphorylase 1", "gene_name": "Upp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATGTEAKDLENHHNDCFIQLSNPNIAAMKEDVLYHFNLSTSTHDFPAMFGDVKFVCVGGSSSRMNTFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKAGPVLSVSHGMGIPSIGIMLHELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAVNECFKPEFEQIVLGKRVIRNTNLDAQLVQELVQCSSDLNEFPMVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQSYLRAAHAAGVRNIEMESSVFATMCSACGLKAAVVCVTLLDRLQGDQINTPHDVLVEYQQRPQRLVGHFIKKSLGRA", "length": 311 }, "evidence": [ { "id": "F1N0Y0", "url": "https://omabrowser.org/oma/group/F1N0Y0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q16831-1", "protein_name": "Uridine phosphorylase 1", "gene_name": "UPP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA", "length": 310 }, "evidence": [ { "id": "F1N0Y0", "url": "https://omabrowser.org/oma/group/F1N0Y0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "uridine phosphorylase activity", "id": "GO:0004850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004850", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "uridine catabolic process", "id": "GO:0006218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006218", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ], "pmid": "" }, { "name": "UMP salvage", "id": "GO:0044206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044206", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ], "pmid": "" }, { "name": "nucleotide catabolic process", "id": "GO:0009166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009166", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y0", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24388", "name": "", "equation": "uridine + phosphate = alpha-D-ribose 1-phosphate + uracil", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0Y0-1", "A0AAF6DLQ4-1" ], "evidence": [ { "id": "24388", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24388" } ] }, { "id": "R-BTA-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0Y0-1", "A0AAF6DLQ4-1" ], "evidence": [ { "id": "R-BTA-74372", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74372" } ] }, { "id": "R-BTA-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N0Y0-1", "A0AAF6DLQ4-1" ], "evidence": [ { "id": "R-BTA-74376", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74376" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6DLQ4", "gene_name": "UPP2", "activity": [ { "ec_number": "2.4.2.3", "activity": "uridine + phosphate = alpha-D-ribose 1-phosphate + uracil.", "evidence": [ { "id": "A0AAF6DLQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ4" } ] }, { "ec_number": "2.4.2.3", "activity": "", "evidence": [ { "id": "A0AAF6DLQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ4" } ] } ] }, { "uniprot_ac": "F1N0Y0", "gene_name": "UPP1", "activity": [ { "ec_number": "2.4.2.3", "activity": "uridine + phosphate = alpha-D-ribose 1-phosphate + uracil.", "evidence": [ { "id": "F1N0Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ] }, { "ec_number": "2.4.2.3", "activity": "", "evidence": [ { "id": "F1N0Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0Y0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 500, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0Y0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0Y0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y0" }, { "id": "PF01048", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01048" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleoside phosphorylase", "eco_id": "ECO_0000259", "start_pos": 244, "end_pos": 494, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.2.3", "ec_name": "uridine + phosphate = alpha-D-ribose 1-phosphate + uracil.", "evidence": [ { "id": "2.4.2.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.3" }, { "id": "2.4.2.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.3" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 105 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Y6-1", "uniprot_ac": "F1N0Y6", "uniprot_id": "F1N0Y6_BOVIN", "mass": { "chemical_mass": 69866.0, "monoisotopic_mass": 69866.0 }, "refseq": { "ac": "XP_015327810", "name": "zinc finger protein 300 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327810" }, "gene_names": [ { "name": "ZNF300", "type": "recommended", "evidence": [ { "id": "F1N0Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ] }, { "name": "ZNF300", "type": "synonym", "evidence": [ { "id": "XP_015327810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327810" } ] } ], "protein_names": [ { "name": "Zinc finger protein 300", "type": "synonym", "evidence": [ { "id": "F1N0Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 300 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015327810", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327810" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF300", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6", "locus": { "chromosome": "7", "start_pos": 62194158, "end_pos": 62259445, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025124", "url": "https://www.ensembl.org/id/ENSBTAG00000025124" } ] } } ], "crossref": [ { "id": "F1N0Y6", "url": "https://alphafold.ebi.ac.uk/entry/F1N0Y6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025124", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025124", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524256", "url": "https://www.ncbi.nlm.nih.gov/gene/524256", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524256", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524256", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N0Y6", "url": "https://www.orthodb.org/?gene=F1N0Y6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015327810", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327810", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Y6-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSQGLVSFKDVAVDFTQEEWQQLDSAQKTLYRDVMLENYSHLVSMGHPVSKPDVISKLEQGEDPWIIKRDIPNWICPYEGQADGRLDRKSNLDNPQSCILGSVSFHNKILKGVIKDGSLYSILKVCQSDGQLQRCQKNRLSRQVTVINNKTMTVESDYRYDALRKIFKECIESDASRNRPYNYDSFKKNSKSNIDLPSCNKNNSRTNLDESFECGKSFIHNVANSNLEKLHNGVIPCNDNEHGNIFSKKQSIILYQNVDTKEKTCVCITCGKAFAKKSQLIVHQRIHTGKKPYDCGACGKAFSEKFHLIVHQRTHTGEKPYECSECGKAFSQKSSLIIHQRVHTGEKPYECSECGKAFSQKSPLIIHQRIHTGEKPYECRECGKAFSQKSQLIIHHRAHTGEKPYECTECGKAFCEKSHLIIHKRIHTGEKPYKCAQCEEAFSRKTELITHQLIHTGEKPYECTACGKTFSRKSQLIIHQRTHTGEKPYKCNECGKAFCQKSHLIGHQRIHTGEKPFVCTECGKAFSQKSHLPGHQRIHTGEKPYVCAECGKAFSQKSDLVLHRRIHTGERPYRCAVCGKAFIQKSQLTVHQRIHSSGKNHSELKTQTSLQY", "length": 613, "header": "tr|F1N0Y6-1|F1N0Y6_BOVIN Isoform 1 of Zinc finger protein 300 OS=Bos taurus OX=9913 GN=ZNF300 PE=3 SV=3 CANONICAL=F1N0Y6-1" }, "isoforms": [ { "isoform_ac": "F1N0Y6-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6/entry", "sequence": { "sequence": "MKSQGLVSFKDVAVDFTQEEWQQLDSAQKTLYRDVMLENYSHLVSMGHPVSKPDVISKLEQGEDPWIIKRDIPNWICPYEGQADGRLDRKSNLDNPQSCILGSVSFHNKILKGVIKDGSLYSILKVCQSDGQLQRCQKNRLSRQVTVINNKTMTVESDYRYDALRKIFKECIESDASRNRPYNYDSFKKNSKSNIDLPSCNKNNSRTNLDESFECGKSFIHNVANSNLEKLHNGVIPCNDNEHGNIFSKKQSIILYQNVDTKEKTCVCITCGKAFAKKSQLIVHQRIHTGKKPYDCGACGKAFSEKFHLIVHQRTHTGEKPYECSECGKAFSQKSSLIIHQRVHTGEKPYECSECGKAFSQKSPLIIHQRIHTGEKPYECRECGKAFSQKSQLIIHHRAHTGEKPYECTECGKAFCEKSHLIIHKRIHTGEKPYKCAQCEEAFSRKTELITHQLIHTGEKPYECTACGKTFSRKSQLIIHQRTHTGEKPYKCNECGKAFCQKSHLIGHQRIHTGEKPFVCTECGKAFSQKSHLPGHQRIHTGEKPYVCAECGKAFSQKSDLVLHRRIHTGERPYRCAVCGKAFIQKSQLTVHQRIHSSGKNHSELKTQTSLQY", "length": 613, "header": "tr|F1N0Y6-1|F1N0Y6_BOVIN Isoform 1 of Zinc finger protein 300 OS=Bos taurus OX=9913 GN=ZNF300 PE=3 SV=3 CANONICAL=F1N0Y6-1" }, "locus": { "chromosome": "7", "start_pos": 62240211, "end_pos": 62232857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035145.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035145.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035023.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035023.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524256", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524256", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1N0Y6", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 601, "end_pos": 603, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0Y6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 613, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0Y6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0Y6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 266, "end_pos": 293, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N0Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Y6" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 78, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 203, "end_pos": 205 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 601, "end_pos": 603 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Z3-1", "uniprot_ac": "F1N0Z3", "uniprot_id": "F1N0Z3_BOVIN", "mass": { "chemical_mass": 31252.0, "monoisotopic_mass": 31252.0 }, "refseq": {}, "gene_names": [ { "name": "ESX1", "type": "recommended", "evidence": [ { "id": "F1N0Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ] } ], "protein_names": [ { "name": "ESX homeobox 1", "type": "synonym", "evidence": [ { "id": "F1N0Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ESX1", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3", "locus": { "chromosome": "X", "start_pos": 52955361, "end_pos": 52961688, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005953", "url": "https://www.ensembl.org/id/ENSBTAG00000005953" } ] } } ], "crossref": [ { "id": "F1N0Z3", "url": "https://alphafold.ebi.ac.uk/entry/F1N0Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005953", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005953", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FDEAQYP", "url": "https://omabrowser.org/oma/group/FDEAQYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0Z3", "url": "https://www.orthodb.org/?gene=F1N0Z3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24329", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24329", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24329:SF545", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24329:SF545", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Z3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSSHFDIGFHNLGIGEDELHDVEPTLISEVLNGVEDETRSSPEPGEAAAAAAANYFGEADSNLLDDENREGNENRAGDENRAGDENRAGDENREGNGGDIEPPPQQEEPGPQAVQGPQNAAVKPRRCRTVFTQLQLLELERVFRRVQYPDVFAREDIARRLNLAERRVQVWFQNRRAKWRRYQRALMFRNVHPAALGHPMGVFFNGPYHVFQPGWRYVPAVPRPGLPPGVPPPPVLPAPLPPRPWRMPFPQPVPVPHYAMAPVGLAWAPIGHFVGPRF", "length": 279, "header": "tr|F1N0Z3-1|F1N0Z3_BOVIN Isoform 1 of ESX homeobox 1 OS=Bos taurus OX=9913 GN=ESX1 PE=4 SV=1 CANONICAL=F1N0Z3-1" }, "isoforms": [ { "isoform_ac": "F1N0Z3-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3/entry", "sequence": { "sequence": "MDSSHFDIGFHNLGIGEDELHDVEPTLISEVLNGVEDETRSSPEPGEAAAAAAANYFGEADSNLLDDENREGNENRAGDENRAGDENRAGDENREGNGGDIEPPPQQEEPGPQAVQGPQNAAVKPRRCRTVFTQLQLLELERVFRRVQYPDVFAREDIARRLNLAERRVQVWFQNRRAKWRRYQRALMFRNVHPAALGHPMGVFFNGPYHVFQPGWRYVPAVPRPGLPPGVPPPPVLPAPLPPRPWRMPFPQPVPVPHYAMAPVGLAWAPIGHFVGPRF", "length": 279, "header": "tr|F1N0Z3-1|F1N0Z3_BOVIN Isoform 1 of ESX homeobox 1 OS=Bos taurus OX=9913 GN=ESX1 PE=4 SV=1 CANONICAL=F1N0Z3-1" }, "locus": { "chromosome": "X", "start_pos": 52961609, "end_pos": 52955507, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007812.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007812.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007812.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007812.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8N693-1", "protein_name": "Homeobox protein ESX1", "gene_name": "ESX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESLRGYTHSDIGYRSLAVGEDIEEVNDEKLTVTSLMARGGEDEENTRSKPEYGTEAENNVGTEGSVPSDDQDREGGGGHEPEQQQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPAEGPQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMVPMPPRPPIAPMPPMAPVPPGSRMAPVPPGPRMAPVPPWPPMAPVPPWPPMAPVPTGPPMAPVPPGPPMARVPPGPPMARVPPGPPMAPLPPGPPMAPLPPGPPMAPLPPGPPMAPLPPRSHVPHTGLAPVHITWAPVINSYYACPFF", "length": 406 }, "evidence": [ { "id": "F1N0Z3", "url": "https://omabrowser.org/oma/group/F1N0Z3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z3", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0Z3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 279, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0Z3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0Z3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N0Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Z3" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 123, "end_pos": 183, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0Z5-1", "uniprot_ac": "F1N0Z5", "uniprot_id": "F1N0Z5_BOVIN", "mass": { "chemical_mass": 12031.0, "monoisotopic_mass": 12031.0 }, "refseq": {}, "gene_names": [ { "name": "EMC6", "type": "recommended", "evidence": [ { "id": "F1N0Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 6", "type": "recommended", "evidence": [ { "id": "F1N0Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 93", "type": "synonym", "evidence": [ { "id": "F1N0Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC6", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5", "locus": { "chromosome": "19", "start_pos": 24366614, "end_pos": 24363589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025121", "url": "https://www.ensembl.org/id/ENSBTAG00000025121" } ] } } ], "crossref": [ { "id": "F1N0Z5", "url": "https://alphafold.ebi.ac.uk/entry/F1N0Z5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025121", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025121", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MKANFEW", "url": "https://omabrowser.org/oma/group/MKANFEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0Z5", "url": "https://www.orthodb.org/?gene=F1N0Z5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20994:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20994:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0Z5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASILLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110, "header": "tr|F1N0Z5-1|F1N0Z5_BOVIN Isoform 1 of ER membrane protein complex subunit 6 OS=Bos taurus OX=9913 GN=EMC6 PE=3 SV=1 CANONICAL=F1N0Z5-1" }, "isoforms": [ { "isoform_ac": "F1N0Z5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5/entry", "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASILLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110, "header": "tr|F1N0Z5-1|F1N0Z5_BOVIN Isoform 1 of ER membrane protein complex subunit 6 OS=Bos taurus OX=9913 GN=EMC6 PE=3 SV=1 CANONICAL=F1N0Z5-1" }, "locus": { "chromosome": "19", "start_pos": 24366155, "end_pos": 24365826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035139.3", "url": "https://www.ensembl.org/id/ENSBTAT00000035139.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000035017.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RMS8-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "EMC6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAVVAKREGPQFISEAAVRGNAAILDYCRTSVSALSGATAGILGLTGLHGFIFYFLASVLLSLLLVLKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4F845-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "EMC6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVVVKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASILLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4ABX9-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "Emc6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q1ZXH4-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "emc6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLHPQQMQEQQQQQQEAQAASIIPEHYEMEYIQRNNKTVSFCQIPISILGGAIAGVIGFSGVYGFLFYFFIYITFCSLFTLKENKNLHLYFPNPRSIWFDSIGAGLMPYILFWTFLYNIIHIY", "length": 123 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6P0F0-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "emc6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASVAAKREGPQFISEVSVRGNGAVLDYCRTSVSALSGATAGILGLTGLYGFVFYFLASFLLSLLLILKAGRRWNKCFKSRRLLFTGGLVGGLFTYVLFWTFLYGMVHVY", "length": 110 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BV81-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "EMC6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQW0-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "Emc6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VBZ8-1", "protein_name": "ER membrane protein complex subunit 6", "gene_name": "EMC6", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNRVKTTQSKTGEIIAYSEGAIRNNISAVEYCRTSMAAISGCAAGILGLSGTLGFLFYFLSVFVLWILVLVKSGTQWRKFFINRRNLLTNQFMGGLCTYVLFWTFLYGMVHVY", "length": 113 }, "evidence": [ { "id": "F1N0Z5", "url": "https://omabrowser.org/oma/group/F1N0Z5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "pmid": "" }, { "name": "omegasome membrane", "id": "GO:1903349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903349", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "pmid": "" }, { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "F1N0Z5", "url": "https://www.uniprot.org/uniprotkb/F1N0Z5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N0Z5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 110, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N0Z5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N0Z5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N130-1", "uniprot_ac": "F1N130", "uniprot_id": "F1N130_BOVIN", "mass": { "chemical_mass": 42799.0, "monoisotopic_mass": 42799.0 }, "refseq": { "ac": "XP_010819878", "name": "zinc finger protein 275", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819878" }, "gene_names": [ { "name": "ZNF275", "type": "recommended", "evidence": [ { "id": "F1N130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ] }, { "name": "ZNF275", "type": "synonym", "evidence": [ { "id": "XP_010819878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819878" } ] } ], "protein_names": [ { "name": "C2H2-type domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1N130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N130/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 275", "type": "synonym", "evidence": [ { "id": "XP_010819878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819878" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF275", "url": "https://www.uniprot.org/uniprotkb/F1N130", "locus": {} } ], "crossref": [ { "id": "F1N130", "url": "https://alphafold.ebi.ac.uk/entry/F1N130", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020185", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020185", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532314", "url": "https://www.ncbi.nlm.nih.gov/gene/532314", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532314", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532314", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N130", "url": "https://www.orthodb.org/?gene=F1N130", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010819878", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819878", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N130-1", "url": "https://www.uniprot.org/uniprotkb/F1N130-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDENAQSQEMASTSSPRASEPSPEVKQNGDSGGKGGSPQNLPVEHHFACKECGDTFRLKVLLVQHQRIHSEKKGWECSDCGQVFHGVTELNEHRKSHVAAEPQPGPSWVLDGAVENREQMEKEAKPFECEECGKRFKKNAGLSQHLRVHSREKPFDCEECGRSFKVNTHLFRHQKLHTSEKPFACKTCSRDFLDRQELLKHQRIHTGHLPFDCDDCGKSFRGVNGLAEHQRIHSGAKPYGCPHCGKLFRRSSELTKHRRIHTGEKPYECGQCGKAFRQSSSLLEHQRIHTGERPYACGDCGKAFRGPSDLIKHRRIHSGLKPYECDKCGKAFRRSSGLSRHRRTHSGTRRCECSECGRVFKRRSALQKHQPTHHE", "length": 376, "header": "tr|F1N130-1|F1N130_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=ZNF275 PE=3 SV=4 CANONICAL=F1N130-1" }, "isoforms": [ { "isoform_ac": "F1N130-1", "url": "https://www.uniprot.org/uniprotkb/F1N130/entry", "sequence": { "sequence": "MMDENAQSQEMASTSSPRASEPSPEVKQNGDSGGKGGSPQNLPVEHHFACKECGDTFRLKVLLVQHQRIHSEKKGWECSDCGQVFHGVTELNEHRKSHVAAEPQPGPSWVLDGAVENREQMEKEAKPFECEECGKRFKKNAGLSQHLRVHSREKPFDCEECGRSFKVNTHLFRHQKLHTSEKPFACKTCSRDFLDRQELLKHQRIHTGHLPFDCDDCGKSFRGVNGLAEHQRIHSGAKPYGCPHCGKLFRRSSELTKHRRIHTGEKPYECGQCGKAFRQSSSLLEHQRIHTGERPYACGDCGKAFRGPSDLIKHRRIHSGLKPYECDKCGKAFRRSSGLSRHRRTHSGTRRCECSECGRVFKRRSALQKHQPTHHE", "length": 376, "header": "tr|F1N130-1|F1N130_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=ZNF275 PE=3 SV=4 CANONICAL=F1N130-1" }, "locus": { "chromosome": "X", "start_pos": 36607628, "end_pos": 36606501, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030211.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030211.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030196.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030196.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532314", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532314", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1N130", "url": "https://www.uniprot.org/uniprotkb/F1N130" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N130-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N130-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N130" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N130" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 75, "start_aa": "Phe", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N134-1", "uniprot_ac": "F1N134", "uniprot_id": "F1N134_BOVIN", "mass": { "chemical_mass": 67828.0, "monoisotopic_mass": 67828.0 }, "refseq": {}, "gene_names": [ { "name": "LOC509810", "type": "recommended", "evidence": [ { "id": "F1N134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ] } ], "protein_names": [ { "name": "Zinc finger protein 211", "type": "recommended", "evidence": [ { "id": "F1N134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N134/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC509810", "url": "https://www.uniprot.org/uniprotkb/F1N134", "locus": {} } ], "crossref": [ { "id": "F1N134", "url": "https://alphafold.ebi.ac.uk/entry/F1N134", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KANTCGA", "url": "https://omabrowser.org/oma/group/KANTCGA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N134", "url": "https://www.orthodb.org/?gene=F1N134", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N134-1", "url": "https://www.uniprot.org/uniprotkb/F1N134-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVPALKDPGQSHVTFEDVAVYFSQEEWCLLDEAQIQLYLDVMLENFALVCMLGSWPGVGDEETPFEQSKSAGVSQIGSPRTDSSAEKVQPCKICILVLRNILHLTEEQGTNSGQKANTCGAHGKQFCFTADIQQHQKQHTRETLLQYIMGKLSFLKSCTIHASGSLSPYNEIGKEFVANLGVQPQAKNTRNQQNNSKECEVVFHSGKSHQSSGEGKKASSRTDILVQDERILTSEQSCEFTGGTHQSNHVQHQKGHIRGRSSECTECGKSFGQRKYLRIHRRIHTGERPYQCKECDKSFIYKNRFIGHQRIHTGERPYECTQCGKCFTHQSSFYVHQRIHTGERPYKCNECGKSFINNSNFHRHQRIHKGERPYTCNVCGKSFITLAGIRYHQKVHNREELYKGSDYETSFNQMHHLSSSRKIHTGEKPYECSECGKSFTASSSLWYHQRIHSGERPHECSECGKSFIVKLSLRNHQRVHTEERPYKCSECGKCFTSSSSLLRHQRVHNGERPYECSECGKSFTASYGLRYHQRVHSGEKPYECSECGKSFTASSSLRYHQRVHSGEKPYECSECGKSFTASYGLQYHQRVHH", "length": 594, "header": "tr|F1N134-1|F1N134_BOVIN Isoform 1 of Zinc finger protein 211 OS=Bos taurus OX=9913 GN=LOC509810 PE=3 SV=3 CANONICAL=F1N134-1" }, "isoforms": [ { "isoform_ac": "F1N134-1", "url": "https://www.uniprot.org/uniprotkb/F1N134/entry", "sequence": { "sequence": "MAVPALKDPGQSHVTFEDVAVYFSQEEWCLLDEAQIQLYLDVMLENFALVCMLGSWPGVGDEETPFEQSKSAGVSQIGSPRTDSSAEKVQPCKICILVLRNILHLTEEQGTNSGQKANTCGAHGKQFCFTADIQQHQKQHTRETLLQYIMGKLSFLKSCTIHASGSLSPYNEIGKEFVANLGVQPQAKNTRNQQNNSKECEVVFHSGKSHQSSGEGKKASSRTDILVQDERILTSEQSCEFTGGTHQSNHVQHQKGHIRGRSSECTECGKSFGQRKYLRIHRRIHTGERPYQCKECDKSFIYKNRFIGHQRIHTGERPYECTQCGKCFTHQSSFYVHQRIHTGERPYKCNECGKSFINNSNFHRHQRIHKGERPYTCNVCGKSFITLAGIRYHQKVHNREELYKGSDYETSFNQMHHLSSSRKIHTGEKPYECSECGKSFTASSSLWYHQRIHSGERPHECSECGKSFIVKLSLRNHQRVHTEERPYKCSECGKCFTSSSSLLRHQRVHNGERPYECSECGKSFTASYGLRYHQRVHSGEKPYECSECGKSFTASSSLRYHQRVHSGEKPYECSECGKSFTASYGLQYHQRVHH", "length": 594, "header": "tr|F1N134-1|F1N134_BOVIN Isoform 1 of Zinc finger protein 211 OS=Bos taurus OX=9913 GN=LOC509810 PE=3 SV=3 CANONICAL=F1N134-1" }, "locus": { "chromosome": "18", "start_pos": 65036773, "end_pos": 65024534, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044684.6", "url": "https://www.ensembl.org/id/ENSBTAT00000044684.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042161.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042161.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N134", "url": "https://www.uniprot.org/uniprotkb/F1N134" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N134-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 594, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N134-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N134" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N134" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 263, "end_pos": 290, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N134" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 85, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 358, "end_pos": 360 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N136-1", "uniprot_ac": "F1N136", "uniprot_id": "F1N136_BOVIN", "mass": { "chemical_mass": 34209.0, "monoisotopic_mass": 34209.0 }, "refseq": { "ac": "XP_002685238", "name": "magnesium transporter NIPA1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685238" }, "gene_names": [ { "name": "NIPA1", "type": "recommended", "evidence": [ { "id": "F1N136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ] }, { "name": "NIPA1", "type": "synonym", "evidence": [ { "id": "XP_002685238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685238" } ] } ], "protein_names": [ { "name": "NIPA magnesium transporter 1", "type": "synonym", "evidence": [ { "id": "F1N136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N136/entry#names_and_taxonomy" } ] }, { "name": "magnesium transporter NIPA1", "type": "synonym", "evidence": [ { "id": "XP_002685238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685238" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIPA1", "url": "https://www.uniprot.org/uniprotkb/F1N136", "locus": { "chromosome": "2", "start_pos": 1039956, "end_pos": 989569, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066033", "url": "https://www.ensembl.org/id/ENSBTAG00000066033" } ] } } ], "crossref": [ { "id": "F1N136", "url": "https://alphafold.ebi.ac.uk/entry/F1N136", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539162", "url": "https://www.ncbi.nlm.nih.gov/gene/539162", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539162", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539162", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGKSNIM", "url": "https://omabrowser.org/oma/group/YGKSNIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N136", "url": "https://www.orthodb.org/?gene=F1N136", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12570", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12570:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12570:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5223345", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002685238", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685238", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N136-1", "url": "https://www.uniprot.org/uniprotkb/F1N136-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDIFHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNVKTD", "length": 324, "header": "tr|F1N136-1|F1N136_BOVIN Isoform 1 of NIPA magnesium transporter 1 OS=Bos taurus OX=9913 GN=NIPA1 PE=3 SV=3 CANONICAL=F1N136-1" }, "isoforms": [ { "isoform_ac": "F1N136-1", "url": "https://www.uniprot.org/uniprotkb/F1N136/entry", "sequence": { "sequence": "MGTAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDIFHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNVKTD", "length": 324, "header": "tr|F1N136-1|F1N136_BOVIN Isoform 1 of NIPA magnesium transporter 1 OS=Bos taurus OX=9913 GN=NIPA1 PE=3 SV=3 CANONICAL=F1N136-1" }, "locus": { "chromosome": "2", "start_pos": 1034410, "end_pos": 989642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002985.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002985.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002985.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002985.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539162", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539162", "resource": "KEGG Pathway" }, { "id": "R-BTA-5223345", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "resource": "Reactome", "description": "Miscellaneous transport and binding events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LT49-1", "protein_name": "NIPA magnesium transporter 1", "gene_name": "Nipa1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPIHPLTRLSPHRLTSQSDLELRLPLRPAPRRSSPSRWGAVRARAAEGGAGGMGTAAAAAAAGEGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTSQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD", "length": 376 }, "evidence": [ { "id": "F1N136", "url": "https://omabrowser.org/oma/group/F1N136/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7RTP0-1", "protein_name": "Magnesium transporter NIPA1", "gene_name": "NIPA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD", "length": 329 }, "evidence": [ { "id": "F1N136", "url": "https://omabrowser.org/oma/group/F1N136/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BHK1-1", "protein_name": "Magnesium transporter NIPA1", "gene_name": "Nipa1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTAAAAAAAGEGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD", "length": 323 }, "evidence": [ { "id": "F1N136", "url": "https://omabrowser.org/oma/group/F1N136/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "magnesium ion transport", "id": "GO:0015693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015693", "evidence": [ { "database": "UniProtKB", "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "magnesium ion transmembrane transporter activity", "id": "GO:0015095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015095", "evidence": [ { "database": "UniProtKB", "id": "F1N136", "url": "https://www.uniprot.org/uniprotkb/F1N136" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N136-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 324, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N136-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N136" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N145-1", "uniprot_ac": "F1N145", "uniprot_id": "F1N145_BOVIN", "mass": { "chemical_mass": 12689.0, "monoisotopic_mass": 12689.0 }, "refseq": {}, "gene_names": [ { "name": "SST", "type": "recommended", "evidence": [ { "id": "F1N145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ] } ], "protein_names": [ { "name": "Somatostatin", "type": "recommended", "evidence": [ { "id": "F1N145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N145/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145#function" }, { "database": "UniProtKB", "id": "ARBA00037261", "url": "https://www.uniprot.org/uniprotkb/ARBA00037261#function" } ] }, { "annotation": "May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH.", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145#function" }, { "database": "UniProtKB", "id": "ARBA00045353", "url": "https://www.uniprot.org/uniprotkb/ARBA00045353#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SST", "url": "https://www.uniprot.org/uniprotkb/F1N145", "locus": { "chromosome": "1", "start_pos": 79659364, "end_pos": 79657917, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017312", "url": "https://www.ensembl.org/id/ENSBTAG00000017312" } ] } } ], "crossref": [ { "id": "F1N145", "url": "https://alphafold.ebi.ac.uk/entry/F1N145", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017312", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR004250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AEQDDMR", "url": "https://omabrowser.org/oma/group/AEQDDMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N145", "url": "https://www.orthodb.org/?gene=F1N145", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10558", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10558", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10558:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10558:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N145-1", "url": "https://www.uniprot.org/uniprotkb/F1N145-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSCRLQCALAALSIVLALGGVTGAPSDPRLRQFLQKSLAAAAGKQKLAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116, "header": "tr|F1N145-1|F1N145_BOVIN Isoform 1 of Somatostatin OS=Bos taurus OX=9913 GN=SST PE=3 SV=1 CANONICAL=F1N145-1" }, "isoforms": [ { "isoform_ac": "F1N145-1", "url": "https://www.uniprot.org/uniprotkb/F1N145/entry", "sequence": { "sequence": "MLSCRLQCALAALSIVLALGGVTGAPSDPRLRQFLQKSLAAAAGKQKLAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116, "header": "tr|F1N145-1|F1N145_BOVIN Isoform 1 of Somatostatin OS=Bos taurus OX=9913 GN=SST PE=3 SV=1 CANONICAL=F1N145-1" }, "locus": { "chromosome": "1", "start_pos": 79659213, "end_pos": 79658027, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023020.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023020.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023020.3", "url": "https://www.ensembl.org/id/ENSBTAP00000023020.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GT93-1", "protein_name": "Somatostatin", "gene_name": "Sst", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116 }, "evidence": [ { "id": "F1N145", "url": "https://omabrowser.org/oma/group/F1N145/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P01168-1", "protein_name": "Somatostatin", "gene_name": "SST", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSCRLQCALAALSIVLALGGVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116 }, "evidence": [ { "id": "F1N145", "url": "https://omabrowser.org/oma/group/F1N145/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P33094-1", "protein_name": "Somatostatin", "gene_name": "SST", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSCRLQCALALLSIALAVGTVSAAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPSQTENEALESEDLSRGAEQDEVRLELERSANSNPALAPRERKAGCKNFFWKTFTSC", "length": 116 }, "evidence": [ { "id": "F1N145", "url": "https://omabrowser.org/oma/group/F1N145/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P60041-1", "protein_name": "Somatostatin", "gene_name": "Sst", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116 }, "evidence": [ { "id": "F1N145", "url": "https://omabrowser.org/oma/group/F1N145/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P60042-1", "protein_name": "Somatostatin", "gene_name": "Sst", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116 }, "evidence": [ { "id": "F1N145", "url": "https://omabrowser.org/oma/group/F1N145/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P61278-1", "protein_name": "Somatostatin", "gene_name": "SST", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC", "length": 116 }, "evidence": [ { "id": "F1N145", "url": "https://omabrowser.org/oma/group/F1N145/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" }, { "name": "regulation of postsynaptic membrane neurotransmitter receptor levels", "id": "GO:0099072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099072", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" }, { "name": "somatostatin signaling pathway", "id": "GO:0038170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038170", "evidence": [ { "database": "UniProtKB", "id": "F1N145", "url": "https://www.uniprot.org/uniprotkb/F1N145" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N145-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 116, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N145-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N145" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N145" }, { "id": "PF03002", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Somatostatin/Cortistatin C-terminal", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 116, "start_aa": "Arg", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N147-1", "uniprot_ac": "F1N147", "uniprot_id": "F1N147_BOVIN", "mass": { "chemical_mass": 51485.0, "monoisotopic_mass": 51485.0 }, "refseq": { "ac": "NP_001268651", "name": "osteoclast stimulatory transmembrane protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268651" }, "gene_names": [ { "name": "OCSTAMP", "type": "recommended", "evidence": [ { "id": "F1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ] }, { "name": "C13H20orf123", "type": "synonym", "evidence": [ { "id": "NP_001268651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268651" } ] }, { "name": "OCSTAMP", "type": "synonym", "evidence": [ { "id": "NP_001268651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268651" } ] } ], "protein_names": [ { "name": "Osteoclast stimulatory transmembrane protein", "type": "synonym", "evidence": [ { "id": "F1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N147/entry#names_and_taxonomy" } ] }, { "name": "osteoclast stimulatory transmembrane protein", "type": "synonym", "evidence": [ { "id": "NP_001268651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268651" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OCSTAMP", "url": "https://www.uniprot.org/uniprotkb/F1N147", "locus": { "chromosome": "13", "start_pos": 75242561, "end_pos": 75249138, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027327", "url": "https://www.ensembl.org/id/ENSBTAG00000027327" } ] } } ], "crossref": [ { "id": "F1N147", "url": "https://alphafold.ebi.ac.uk/entry/F1N147", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027327", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027327", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509089", "url": "https://www.ncbi.nlm.nih.gov/gene/509089", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509089", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509089", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ARCVFSM", "url": "https://omabrowser.org/oma/group/ARCVFSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N147", "url": "https://www.orthodb.org/?gene=F1N147", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21041", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21041", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21041:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21041:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001268651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268651", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N147-1", "url": "https://www.uniprot.org/uniprotkb/F1N147-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPPGGTLEHLVRTGWRYWYLGLRKALALLQATWITYSQPVPASCGQLLTQILLCGSLALAAASLTYCWLASSLLYPLGPSAVVATVCGLLAFLGLVLVPPARCLFALSVPTLGTEQGRRLLLSWSTATLTIAVVPNILANLRATGQVLRCVTEGSLESLLNTTHWLQTASQALNPDGQAGSQGLTLQAQGDSAAAFRLHVLRVTQQVLEDFSGLESSARVVALGTQRVVTGLFMLGLLLDSAWYLYRYLTDLRFDNIYATRQLTQRLAEVGATHLTASPPAWLLWAAQPRLSQAELLSCLVRLGLFTLLLMAMAVTVAMDYVAFLLAQAAVDWARELPAVPVTLTIKYNAAYTILGFLPFLFNRPPLENPYLSAHNSFQWELRFTAPGCPLLPAQRPHTAAPLAAGALQLAACSTVLLETYARRLRHSIAASFFRTQEAKRVCHLHARLQRRYDRHRGQPAQPQDTSSCS", "length": 471, "header": "tr|F1N147-1|F1N147_BOVIN Isoform 1 of Osteoclast stimulatory transmembrane protein OS=Bos taurus OX=9913 GN=OCSTAMP PE=4 SV=3 CANONICAL=F1N147-1" }, "isoforms": [ { "isoform_ac": "F1N147-1", "url": "https://www.uniprot.org/uniprotkb/F1N147/entry", "sequence": { "sequence": "MRPPGGTLEHLVRTGWRYWYLGLRKALALLQATWITYSQPVPASCGQLLTQILLCGSLALAAASLTYCWLASSLLYPLGPSAVVATVCGLLAFLGLVLVPPARCLFALSVPTLGTEQGRRLLLSWSTATLTIAVVPNILANLRATGQVLRCVTEGSLESLLNTTHWLQTASQALNPDGQAGSQGLTLQAQGDSAAAFRLHVLRVTQQVLEDFSGLESSARVVALGTQRVVTGLFMLGLLLDSAWYLYRYLTDLRFDNIYATRQLTQRLAEVGATHLTASPPAWLLWAAQPRLSQAELLSCLVRLGLFTLLLMAMAVTVAMDYVAFLLAQAAVDWARELPAVPVTLTIKYNAAYTILGFLPFLFNRPPLENPYLSAHNSFQWELRFTAPGCPLLPAQRPHTAAPLAAGALQLAACSTVLLETYARRLRHSIAASFFRTQEAKRVCHLHARLQRRYDRHRGQPAQPQDTSSCS", "length": 471, "header": "tr|F1N147-1|F1N147_BOVIN Isoform 1 of Osteoclast stimulatory transmembrane protein OS=Bos taurus OX=9913 GN=OCSTAMP PE=4 SV=3 CANONICAL=F1N147-1" }, "locus": { "chromosome": "13", "start_pos": 75249112, "end_pos": 75243046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039180.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039180.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038980.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038980.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 317, "start_aa": "Thr", "end_pos": 317, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr317", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509089", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509089", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZHW3-1", "protein_name": "Osteoclast stimulatory transmembrane protein", "gene_name": "Ocstamp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNSREAVQHLFGLGWKFWRLGICRAVVPLQAAWNAFSQPVPASRNELLTQLLLCVSLASLIAGLVHHWLVSLQLYPLGPPTLVTALCGLFVFLSLGLVPPIRCLFALSVPTLGSEQGRRLLLSYSAANLAAAVMPNVLANVRAVGRVLGCVTEGSLESLLNTTYQLRQAARELVPAGQAVSRSLTFEVEGNGSAFRLHTHTVTQQILEDFSGLEFLARAALGTQRVVTGLFLLGLLGESAWYLHRYLTDLRFDNIYATRQLVRQLTQAGATHLLAAPPPWLLQTAQSKLSQEELLSCLLRLGLLALLLIATAVTVASDYGAFLLARAAVTWAQNLPSVPITLTVKYDASYKVLDFILFVLNQPPVESVFASVQRSFQWELRFTSHNCHLPQAQPPRVTAALAAGALQLLAGATLVLQTYAWRLRHAIAASFFPAQEARRLSHLQARLRRRHDQSDHPDRHANTVGTRRPRKPGQGTSALESQGSQAHDPLSASV", "length": 495 }, "evidence": [ { "id": "F1N147", "url": "https://omabrowser.org/oma/group/F1N147/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BR26-1", "protein_name": "Osteoclast stimulatory transmembrane protein", "gene_name": "OCSTAMP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGHPGAAEQLVKTGWRSWHLGFWKALAPLQAAWDAFSQPVPASCGQLLTQLLLCASLAAAAAGLVYHWLASLLLYPPGPSAMVATVCGLLVFLSLGLVPPVRCLFALSVPTLGMEQGRRLLLSYSTATLAIAVVPNVLANVGAAGQVLRCVTEGSLESLLNTTHQLHAASRALGPTGQAGSRGLTFEAQDNGSAFYLHMLRVTQQVLEDFSGLESLARAAALGTQRVVTGLFMLGLLVESAWYLHCYLTDLRFDNIYATQQLTQRLAQAQATHLLAPPPTWLLQAAQLRLSQEELLSCLLRLGLLALLLVATAVAVATDHVAFLLAQATVDWAQKLPTVPITLTVKYDVAYTVLGFIPFLFNQLAPESPFLSVHSSYQWELRLTSARCPLLPARRPRAAAPLAAGALQLLAGSTVLLEAYARRLRHAIAASFFTAQEARRVRHLHARLQRRHDRHQGQQLPLGDPSCVPTPRPACKPPAWIDYRLDALRTESSEGEGKELWSCRDLSCNLGPVPPPCVTLGKSLHLSEPRFLHLHNDSIFTIDVTYFPRRDVVRMEGNTGHDRPG", "length": 566 }, "evidence": [ { "id": "F1N147", "url": "https://omabrowser.org/oma/group/F1N147/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D611-1", "protein_name": "Osteoclast stimulatory transmembrane protein", "gene_name": "Ocstamp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRTIRAATEHLFGLGWKFWRLGICKAVVPLQAAWKAFSQPVPASCNELLTQLLLCVSLASLIAGLAHHWLVSLQLYPLGPPALVTSLCGLFVFLSLGLVPPIRCLFVLSVPTLGSKQGRRLLLSYSAANLAVAVVPNVLGNVRAAGQVLSCVTEGSLESLLNTTYQLRQAARELGPASRAGSRSLTFEVEGKGSAFRLHMHTITQEILEDFSGLEFLARAALGTQRVVTGLFLLGLLGESAWYLHRYLTDLRFDNIYATRQLVRQLAQAGATHLLTSPPPWLLQTAQPKLSREELLSCLLRLGLLALLLVATAVTVASDYGAFLLAQAAVAWAQKLPTVPITLTVKYDASYKVLDFILFVLNQPPVESVFASMQRSFQWELRFTPHDCHLPQAQPPRVTAALAAGALQLLAGATLVLQAYAWRLRHTIAASFFPDQEARRLSHLQARLQRRHNQSDHLNKQPGTMATRESRKPGQGTRTLESQGPQAHDSLGPPYDLE", "length": 498 }, "evidence": [ { "id": "F1N147", "url": "https://omabrowser.org/oma/group/F1N147/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "pmid": "" }, { "name": "cellular response to estrogen stimulus", "id": "GO:0071391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071391", "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "pmid": "" }, { "name": "positive regulation of osteoclast differentiation", "id": "GO:0045672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045672", "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "pmid": "" }, { "name": "multinuclear osteoclast differentiation", "id": "GO:0072674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072674", "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "pmid": "" }, { "name": "positive regulation of osteoclast proliferation", "id": "GO:0090290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090290", "evidence": [ { "database": "UniProtKB", "id": "F1N147", "url": "https://www.uniprot.org/uniprotkb/F1N147" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N147-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 471, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N147-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N147" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N147" }, { "id": "PF07782", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07782" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dendritic cell-specific transmembrane protein-like", "eco_id": "ECO_0000259", "start_pos": 255, "end_pos": 447, "start_aa": "Phe", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 317 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N163-1", "uniprot_ac": "F1N163", "uniprot_id": "F1N163_BOVIN", "mass": { "chemical_mass": 26280.0, "monoisotopic_mass": 26280.0 }, "refseq": {}, "gene_names": [ { "name": "EFNA3", "type": "recommended", "evidence": [ { "id": "F1N163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ] } ], "protein_names": [ { "name": "Ephrin-A3", "type": "recommended", "evidence": [ { "id": "F1N163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N163/entry#names_and_taxonomy" } ] }, { "name": "EHK1 ligand", "type": "synonym", "evidence": [ { "id": "F1N163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N163/entry#names_and_taxonomy" } ] }, { "name": "EPH-related receptor tyrosine kinase ligand 3", "type": "synonym", "evidence": [ { "id": "F1N163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N163/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163#function" }, { "database": "UniProtKB", "id": "ARBA00056077", "url": "https://www.uniprot.org/uniprotkb/ARBA00056077#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFNA3", "url": "https://www.uniprot.org/uniprotkb/F1N163", "locus": { "chromosome": "3", "start_pos": 15512395, "end_pos": 15521121, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033423", "url": "https://www.ensembl.org/id/ENSBTAG00000033423" } ] } } ], "crossref": [ { "id": "F1N163", "url": "https://alphafold.ebi.ac.uk/entry/F1N163", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033423", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033423", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10425", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10425", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LCNFPLC", "url": "https://omabrowser.org/oma/group/LCNFPLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N163", "url": "https://www.orthodb.org/?gene=F1N163", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11304", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11304", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11304:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11304:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00812", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00812", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928663", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N163-1", "url": "https://www.uniprot.org/uniprotkb/F1N163-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRDGYRTCNASQGSKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPHVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTLLAS", "length": 238, "header": "tr|F1N163-1|F1N163_BOVIN Isoform 1 of Ephrin-A3 OS=Bos taurus OX=9913 GN=EFNA3 PE=3 SV=1 CANONICAL=F1N163-1" }, "isoforms": [ { "isoform_ac": "F1N163-1", "url": "https://www.uniprot.org/uniprotkb/F1N163/entry", "sequence": { "sequence": "MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRDGYRTCNASQGSKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPHVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTLLAS", "length": 238, "header": "tr|F1N163-1|F1N163_BOVIN Isoform 1 of Ephrin-A3 OS=Bos taurus OX=9913 GN=EFNA3 PE=3 SV=1 CANONICAL=F1N163-1" }, "locus": { "chromosome": "3", "start_pos": 15521093, "end_pos": 15513399, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026958.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026958.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026958.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026958.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2682334", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "resource": "Reactome", "description": "EPH-Ephrin signaling" }, { "id": "R-BTA-3928663", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928663", "resource": "Reactome", "description": "EPHA-mediated growth cone collapse" }, { "id": "R-BTA-3928665", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "resource": "Reactome", "description": "EPH-ephrin mediated repulsion of cells" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M1Q1X6-1", "protein_name": "Ephrin-A3", "gene_name": "efna3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALAAVSLYLLALAWTNLRPVHGNNRHAVYWNSSNIHLRREGYTVQVSVNDYLDIYCPHYNQSQRGSLERGVAEQYVLYMVSYRGYRTCDPQMGFKRWECNRPHAPHAPIKFSEKFQRYSAFSLGYEFNVGHEYYYISTPIHHHGHSCLRLRVYVCCSTVSNSDDDSSPPDYTVRPKLHDIDEFNPEIPKLEKSVSGSSPSGDRLLITVATLLLAALLVS", "length": 220 }, "evidence": [ { "id": "F1N163", "url": "https://omabrowser.org/oma/group/F1N163/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0LV88-1", "protein_name": "Ephrin-A3", "gene_name": "Efna3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQGRILGWAQVPGLGSCKLMPSDCRPSGQASPLFFCFLPHSRGPRYFQYRLKALGGPTTPGSTHEKSSRCVQRHSSKSLRREGYTVQVNVNDYLDIYCPHYNSSGPGGGAEQYVLYMVNLSGYRTCNASQGSKRWECNRQHASHSPIKFSEKFQRYSAFSLGYEFHAGQEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTLLAS", "length": 265 }, "evidence": [ { "id": "F1N163", "url": "https://omabrowser.org/oma/group/F1N163/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O08545-1", "protein_name": "Ephrin-A3", "gene_name": "Efna3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGPGGGAEQYVLYMVNLSGYRTCNASQGSKRWECNRQHASHSPIKFSEKFQRYSAFSLGYEFHAGQEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTLLAS", "length": 230 }, "evidence": [ { "id": "F1N163", "url": "https://omabrowser.org/oma/group/F1N163/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P52797-1", "protein_name": "Ephrin-A3", "gene_name": "EFNA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS", "length": 238 }, "evidence": [ { "id": "F1N163", "url": "https://omabrowser.org/oma/group/F1N163/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ephrin receptor binding", "id": "GO:0046875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046875", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" }, { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" }, { "name": "positive regulation of amyloid precursor protein catabolic process", "id": "GO:1902993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902993", "evidence": [ { "database": "UniProtKB", "id": "F1N163", "url": "https://www.uniprot.org/uniprotkb/F1N163" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N163-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 238, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N163-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N163" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N163" }, { "id": "PS51551", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51551" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ephrin RBD", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 169, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 38, "end_pos": 40 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N170-1", "uniprot_ac": "F1N170", "uniprot_id": "F1N170_BOVIN", "mass": { "chemical_mass": 34233.0, "monoisotopic_mass": 34233.0 }, "refseq": { "ac": "NP_001377687", "name": "olfactory receptor 2Z1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377687" }, "gene_names": [ { "name": "OR2Z1", "type": "recommended", "evidence": [ { "id": "F1N170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N170" } ] }, { "name": "OR2Z1", "type": "synonym", "evidence": [ { "id": "NP_001377687", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377687" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N170/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2Z1", "type": "synonym", "evidence": [ { "id": "NP_001377687", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377687" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377687" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2Z1", "url": "https://www.uniprot.org/uniprotkb/F1N170", "locus": { "chromosome": "7", "start_pos": 17265272, "end_pos": 17264340, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051841", "url": "https://www.ensembl.org/id/ENSBTAG00000051841" } ] } } ], "crossref": [ { "id": "F1N170", "url": "https://alphafold.ebi.ac.uk/entry/F1N170", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "107132616", "url": "https://www.ncbi.nlm.nih.gov/gene/107132616", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:107132616", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:107132616", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377687", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N170-1", "url": "https://www.uniprot.org/uniprotkb/F1N170-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQSVASDFILVGLFSRSGSPQLLFFLVAVMFIMGLLGNTTLLFLICVDSRLHTPMYFLLSQLSLFDVGFPLVTIPKMASDFLQGEGSISFGGCAAQIFFLTLMGVAEGILLALMSYDRYVAVCHPLQYSLLMRRQMCLLMVISSWLAGVLNACIQTSITLHFPYCASHTVDHFFCEVPALLKLSCADTSTYELVLSTSGVLILVLPLSLIATSYGHVLGAVLRMRSEEAHHKAFTTCSSHITAVGLFYGAAVFMYMVPGAYHSPHQDNMVSLFYSLITPTLNPLIYSLRNREVWMALVKVLRRPGLRAK", "length": 310, "header": "tr|F1N170-1|F1N170_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2Z1 PE=3 SV=4 CANONICAL=F1N170-1" }, "isoforms": [ { "isoform_ac": "F1N170-1", "url": "https://www.uniprot.org/uniprotkb/F1N170/entry", "sequence": { "sequence": "MNQSVASDFILVGLFSRSGSPQLLFFLVAVMFIMGLLGNTTLLFLICVDSRLHTPMYFLLSQLSLFDVGFPLVTIPKMASDFLQGEGSISFGGCAAQIFFLTLMGVAEGILLALMSYDRYVAVCHPLQYSLLMRRQMCLLMVISSWLAGVLNACIQTSITLHFPYCASHTVDHFFCEVPALLKLSCADTSTYELVLSTSGVLILVLPLSLIATSYGHVLGAVLRMRSEEAHHKAFTTCSSHITAVGLFYGAAVFMYMVPGAYHSPHQDNMVSLFYSLITPTLNPLIYSLRNREVWMALVKVLRRPGLRAK", "length": 310, "header": "tr|F1N170-1|F1N170_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2Z1 PE=3 SV=4 CANONICAL=F1N170-1" }, "locus": { "chromosome": "7", "start_pos": 17265269, "end_pos": 17264340, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014946.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014946.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014946.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014946.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:107132616", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:107132616", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N170", "url": "https://www.uniprot.org/uniprotkb/F1N170" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N170-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 310, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N170-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N170" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N170" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 }, { "start_pos": 39, "end_pos": 41 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N178-1", "uniprot_ac": "F1N178", "uniprot_id": "F1N178_BOVIN", "mass": { "chemical_mass": 85286.0, "monoisotopic_mass": 85286.0 }, "refseq": { "ac": "NP_001179901", "name": "single-minded homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179901" }, "gene_names": [ { "name": "SIM1", "type": "recommended", "evidence": [ { "id": "F1N178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ] }, { "name": "SIM1", "type": "synonym", "evidence": [ { "id": "NP_001179901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179901" } ] } ], "protein_names": [ { "name": "SIM bHLH transcription factor 1", "type": "synonym", "evidence": [ { "id": "F1N178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N178/entry#names_and_taxonomy" } ] }, { "name": "single-minded family bHLH transcription factor 1", "type": "synonym", "evidence": [ { "id": "NP_001179901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179901" } ] }, { "name": "single-minded homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001179901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179901" } ] }, { "name": "single-minded-like 1", "type": "synonym", "evidence": [ { "id": "NP_001179901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179901" } ] } ], "function": [ { "annotation": "Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178#function" }, { "database": "UniProtKB", "id": "ARBA00037499", "url": "https://www.uniprot.org/uniprotkb/ARBA00037499#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SIM1", "url": "https://www.uniprot.org/uniprotkb/F1N178", "locus": { "chromosome": "9", "start_pos": 49555235, "end_pos": 49486150, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002294", "url": "https://www.ensembl.org/id/ENSBTAG00000002294" } ] } } ], "crossref": [ { "id": "F1N178", "url": "https://alphafold.ebi.ac.uk/entry/F1N178", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002294", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002294", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19738", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19738", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537223", "url": "https://www.ncbi.nlm.nih.gov/gene/537223", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537223", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537223", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HQTVGDH", "url": "https://omabrowser.org/oma/group/HQTVGDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N178", "url": "https://www.orthodb.org/?gene=F1N178", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23043", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23043", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23043:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23043:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08447", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08447", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179901", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N178-1", "url": "https://www.uniprot.org/uniprotkb/F1N178-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIAASKPAFSYAGSSTPALTDSRKGAKSRLSGSKSKSRTSPYPQYSGFPTERSESDHESQWGGSPLTDAASPQLLDPADRPGSQHDASCAYRQFSDRGSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGAPQAGREPWWGSRAALPLTKASPESREAYESSMPHIASVHRIHGRGHWDEESVVSSPDPGSASESSDRYRTEQFQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPTGEVCHSSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDMSPHQTPGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "length": 766, "header": "tr|F1N178-1|F1N178_BOVIN Isoform 1 of SIM bHLH transcription factor 1 OS=Bos taurus OX=9913 GN=SIM1 PE=4 SV=3 CANONICAL=F1N178-1" }, "isoforms": [ { "isoform_ac": "F1N178-1", "url": "https://www.uniprot.org/uniprotkb/F1N178/entry", "sequence": { "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQIAASKPAFSYAGSSTPALTDSRKGAKSRLSGSKSKSRTSPYPQYSGFPTERSESDHESQWGGSPLTDAASPQLLDPADRPGSQHDASCAYRQFSDRGSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGAPQAGREPWWGSRAALPLTKASPESREAYESSMPHIASVHRIHGRGHWDEESVVSSPDPGSASESSDRYRTEQFQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPTGEVCHSSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDMSPHQTPGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "length": 766, "header": "tr|F1N178-1|F1N178_BOVIN Isoform 1 of SIM bHLH transcription factor 1 OS=Bos taurus OX=9913 GN=SIM1 PE=4 SV=3 CANONICAL=F1N178-1" }, "locus": { "chromosome": "9", "start_pos": 49554231, "end_pos": 49486349, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002960.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002960.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002960.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002960.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537223", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537223", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZMU8-1", "protein_name": "SIM bHLH transcription factor 1", "gene_name": "Sim1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISPSKPTFSYTSSSTPTITDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPERPGSQHELSCAYRQFPDRGSLCYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPAGRDPWWGSRAALPLTKASPESRETYENSMPHITSVHRLHGRGHWDEDSVVSSPDPGSASESGDRYRSEQYQNSPHEPSKIETLIRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPAGEVCHSSALTSTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPSSDRITKSSLILAKDYLHSDMSPHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "length": 765 }, "evidence": [ { "id": "F1N178", "url": "https://omabrowser.org/oma/group/F1N178/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IIM6-1", "protein_name": "Single-minded homolog 1", "gene_name": "Sim1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPTFSYASSSTPTITDNRKGSKSRLSSTKSKSRTSPYPQYPGFHTERSESDHDSQWGGSPLTDTASPQLLEPERPGSQHEVSCAYRQFPDRSSLCYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPTGRDPWWGSRAALPLTKASPESRETYENSTPHITSVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQNSPHEPSKIETLIRVTQQMIKEEENRLQLRKAPSDQLASINGAGKKHSFCFANYQQAPPAGEVCHTPALASTSPCNHIQQREGKMLSPHENDYDHSPTALSRISSPSSDRITKSSLILAKDYLHSDMSPHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "length": 765 }, "evidence": [ { "id": "F1N178", "url": "https://omabrowser.org/oma/group/F1N178/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P81133-1", "protein_name": "Single-minded homolog 1", "gene_name": "SIM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEVCHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "length": 766 }, "evidence": [ { "id": "F1N178", "url": "https://omabrowser.org/oma/group/F1N178/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61045-1", "protein_name": "Single-minded homolog 1", "gene_name": "Sim1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPTFSYTSSSTPTISDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPERPGSQHELSCAYRQFPDRSSLCYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPTGRDPWWGSRAALPLTKASPESREAYENSMPHITSIHRIHGRGHWDEDSVVSSPDPGSASESGDRYRTEQYQNSPHEPSKIETLIRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPTGEVCHSSALASTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPSSDRITKSSLILAKDYLHSDMSPHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDVTSHLRMQPDPAQGHKGTSVIITNGS", "length": 765 }, "evidence": [ { "id": "F1N178", "url": "https://omabrowser.org/oma/group/F1N178/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N178", "url": "https://www.uniprot.org/uniprotkb/F1N178" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 729, "end_pos": 731, "annotation": "n_glycosylation_sequon" }, { "start_pos": 735, "end_pos": 737, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N178-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 766, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N178-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N178" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N178" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 53, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N178" }, { "id": "PS50112", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50112" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PAS", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 140, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N178" }, { "id": "PS51302", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Single-minded C-terminal", "eco_id": "ECO_0000259", "start_pos": 336, "end_pos": 766, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 626, "end_pos": 628 }, { "start_pos": 729, "end_pos": 731 }, { "start_pos": 735, "end_pos": 737 }, { "start_pos": 764, "end_pos": 766 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N194-1", "uniprot_ac": "F1N194", "uniprot_id": "F1N194_BOVIN", "mass": { "chemical_mass": 57176.0, "monoisotopic_mass": 57176.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF622", "type": "recommended", "evidence": [ { "id": "F1N194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ] } ], "protein_names": [ { "name": "Cytoplasmic 60S subunit biogenesis factor ZNF622", "type": "recommended", "evidence": [ { "id": "F1N194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N194/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 622", "type": "synonym", "evidence": [ { "id": "F1N194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N194/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit.", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194#function" }, { "database": "UniProtKB", "id": "ARBA00059765", "url": "https://www.uniprot.org/uniprotkb/ARBA00059765#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF622", "url": "https://www.uniprot.org/uniprotkb/F1N194", "locus": { "chromosome": "20", "start_pos": 56705774, "end_pos": 56691846, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016441", "url": "https://www.ensembl.org/id/ENSBTAG00000016441" } ] } } ], "crossref": [ { "id": "F1N194", "url": "https://alphafold.ebi.ac.uk/entry/F1N194", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016441", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016441", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WTQTQQQ", "url": "https://omabrowser.org/oma/group/WTQTQQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N194", "url": "https://www.orthodb.org/?gene=F1N194", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13182", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13182", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13182:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13182:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N194-1", "url": "https://www.uniprot.org/uniprotkb/F1N194-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRFSPEVSSQFGSFGVVRPLVARFLPRSRIISRLGMATYTCNTCRAVLEDAEAQRVHYKTDWHRYNLRRKVAGMAPVSLEGFQERVRAQRALAEPESKGAATYCTVCSKKFASFKAYENHLRSRRHVELEKQAVSRKVALMNEKNLEKGLGVDSVDKDAVNAAIQQVIKAQPSTSPKKAAPAPEAEPGCPVAAGGRGTQPRDPGEKPPRLRWFERQAKKLAKQQGEEESEEDLDADDWEDIDSDEDLECEDAEAMEEEEEQDAEEEEAGGSTPLGAIPITDCLFCPHHSSSLTKNVAHMTKVHSFFIPDVEYLSDLKGLIKYLGEKVGVGKICLWCNERGKSFYSTEAVQAHMNDRSHCKLFTDGDALLEFADFYDFRSSYPDHKEGEDHDETEELPSEKTLDYDDETMELILPSGARVGHRSLMRYYKQRFGLSRAVAVAKNRKAVGQVLQQYRALGWTGSTGAALVRQRDMQYVQRMKSKWMLKMGMKNNATRQMHFRPQVLF", "length": 506, "header": "tr|F1N194-1|F1N194_BOVIN Isoform 1 of Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Bos taurus OX=9913 GN=ZNF622 PE=3 SV=3 CANONICAL=F1N194-1" }, "isoforms": [ { "isoform_ac": "F1N194-1", "url": "https://www.uniprot.org/uniprotkb/F1N194/entry", "sequence": { "sequence": "MTRFSPEVSSQFGSFGVVRPLVARFLPRSRIISRLGMATYTCNTCRAVLEDAEAQRVHYKTDWHRYNLRRKVAGMAPVSLEGFQERVRAQRALAEPESKGAATYCTVCSKKFASFKAYENHLRSRRHVELEKQAVSRKVALMNEKNLEKGLGVDSVDKDAVNAAIQQVIKAQPSTSPKKAAPAPEAEPGCPVAAGGRGTQPRDPGEKPPRLRWFERQAKKLAKQQGEEESEEDLDADDWEDIDSDEDLECEDAEAMEEEEEQDAEEEEAGGSTPLGAIPITDCLFCPHHSSSLTKNVAHMTKVHSFFIPDVEYLSDLKGLIKYLGEKVGVGKICLWCNERGKSFYSTEAVQAHMNDRSHCKLFTDGDALLEFADFYDFRSSYPDHKEGEDHDETEELPSEKTLDYDDETMELILPSGARVGHRSLMRYYKQRFGLSRAVAVAKNRKAVGQVLQQYRALGWTGSTGAALVRQRDMQYVQRMKSKWMLKMGMKNNATRQMHFRPQVLF", "length": 506, "header": "tr|F1N194-1|F1N194_BOVIN Isoform 1 of Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Bos taurus OX=9913 GN=ZNF622 PE=3 SV=3 CANONICAL=F1N194-1" }, "locus": { "chromosome": "20", "start_pos": 56705681, "end_pos": 56692045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021860.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021860.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021860.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021860.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P38344-1", "protein_name": "Cytoplasmic 60S subunit biogenesis factor REI1", "gene_name": "REI1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSSGVYTCNSCVLTFDSSDEQRAHMKSDWHRYNLKRRVAQLPPISFETFDSKVSAAAASTSKSAEKEKPVTKKELKRREKQALLEKKKKLLEIARANMLENMQKSQEGNTPDLSKLSLQENEENKEKEEPKKEEPEQLTEEEMAERVMQEKLRNRVDIPLEQCLFCEHNKHFKDVEENLEHMFRTHGFYIPEQKYLVDKIGLVKYMSEKIGLGNICIVCNYQGRTLTAVRQHMLAKRHCKIPYESEDERLEISEFYDFTSSYANFNSNTTPDNEDDWEDVGSDEAGSDDEDLPQEYLYNDGIELHLPTGIKVGHRSLQRYYKQDLKPEVILTEGQGTLVAAETRSFLPAFDKKGVQTQQRVWQTERFDKKRLDKRSAKFVNNQPHYRDQLLQ", "length": 393 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54GN9-1", "protein_name": "C2H2-type zinc finger-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDYDEKIIFTCISCRIQFENSEEQRDHYKSELHRFNLKRKAFDLPPVNEQTFKNKVEALKQEESKSKTPAKFECRICDKEFNSDGTYQQHLTSKKHKEMVSSGAKEVIRNRKPKEEKKLPETIEEAEAILEEKIKNSIKLPLENCLFCNNLGKTVEDNLKHMAKEHSFFVPDIEYLADLEGLLRYLLDKVSIGNVCLYCNGKGKVCQSKDATQTHMRDMGHCKINTDTEDGEDEIIEFYDYSKRDGAVTDENGELVAYKPEITVSTHEITFADGTTIGHRDYAVYYKQKYAPVNRREEFLRGVVGQYKQLGWHEAPKTAYELDKKFTKRTKILELKVGMKKNTQRFVYLPPSIITYIYYTLEININIKPFKYTKDFTKTNFWSNKLAWTKEFHLCSLLHFI", "length": 402 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5FVM3-1", "protein_name": "Reticulophagy regulator 1", "gene_name": "Retreg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPAPEEHATQGCPATEEQEPRPGVPGEEAGPEGAGPQVEEAAGRVAAALTWLLGEPVLWLGWRADELLSWKRPLRSLLAFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRARGAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGEYINQKKRERSEADKEKSHKDDSEIDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGAGTNDEDELSLGLPTELKTKKQQLNSAHRPSKDRQSAAGLSLPLKSDQALHLMSNLAGDVITAAMTAAIKDQLEGARQALAQAAPTPGDDTDTEEGDDFELLDQAELDQIESELGLTQDQGAEAQQSKKSSGFLSNLLGGH", "length": 480 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TM96-1", "protein_name": "Cytoplasmic 60S subunit biogenesis factor ZNF622", "gene_name": "Znf622", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATYTCITCRVAFRDAEMQRAHYKTDWHRYNLRRKVANMAPVTAEGFQERVRAQRAVAEEESKGTATYCTVCSKKFATFNAYENHLKSRRHVELEKKAVQAVSRQVEMMNEKNLEKGLGVDSVNKDAMNAAIQQAIKAQPSTSPKKAPFMPTDESRRVAGAVRRGTPERDPTEKPPRLQWFEQQAKKLAKQQWEESEEEGEEDDEDWEDIDSDDGLECENPGVEEEDAEDAEAEESPPLGAIPITDCLFCSHHSSSLVKNVAHMTKVHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPAEIEDLSSEKILECDDETMELILPSDLEYFD", "length": 386 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8H1G5-1", "protein_name": "Cytoplasmic 60S subunit biogenesis factor REI1 homolog 1", "gene_name": "REIL1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPGLTCNACNMEFKDEEERNLHYKSDWHRYNLKRKVAGVPGVTEALFEARQSALAQEKNKSNEAPMLYTCAICAKGYRSSKAHEQHLQSRSHVLRVSQGTSINGEEDIAIIRQLPRRVQHRGSIDDDSEDEWVEVDSDEELAAEEASDSLSKLNVNESGSAEDMDDDGDADKYELDPTCCLMCDKKHKTLESCMLHMHKHHGFFIPDIEYLKDPEGLLTYLGLKVKRDFMCLYCNELCRPFSSLEAVRKHMEAKSHCKLHYGDGDDEEDAELEEFYDYSSSYVDEAGKQIVVSGETDNTVELVGGSELLITEKSENTTTSKTLGSREFMRYYRQKPRPTSQDSNQIIASLSSRYKSLGLKTVPSKEETLRMKVRKEMSKRGETMRTKIGVKSNVIRNLPNNVPY", "length": 404 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q91VY9-1", "protein_name": "Cytoplasmic 60S subunit biogenesis factor ZNF622", "gene_name": "Znf622", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALTCITCRVAFRDAELQRAHYKTDWHRYNLRRKVAAMAPVTAEGFQERVRAQRAVAEAAEASKGAATYCTACGKKFATFNAYENHLGSRRHAELERKAVRAASRRVELLNAKNLEKGLGADGVDKDAVNAAIQQAIKAQPSTSPKKAPFVPTDECGRAAAGARGVPERDPTEKPPRLQWFEQQAKKLAKQQWEDGEEEGEEEEEDDEDEDWEDIDSDDGLECEDPGVEDQDAEDAAAEESPPLGAIPITDCLFCSHHSSSLVKNVAHMTKVHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPAELEALSTDKILECDDETMELILPSGARVGHRSLMRYYKQRFGLPRAVTVARNQKAVGRVLQQYRALGWMGSTGAALMRERDMQYVQRMKSKWMLKIGMKNNATKQMHFRAQVRF", "length": 476 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969S3-1", "protein_name": "Cytoplasmic 60S subunit biogenesis factor ZNF622", "gene_name": "ZNF622", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATYTCITCRVAFRDADMQRAHYKTDWHRYNLRRKVASMAPVTAEGFQERVRAQRAVAEEESKGSATYCTVCSKKFASFNAYENHLKSRRHVELEKKAVQAVNRKVEMMNEKNLEKGLGVDSVDKDAMNAAIQQAIKAQPSMSPKKAPPAPAKEARNVVAVGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQQEEDSEEEEEDLDGDDWEDIDSDEELECEDTEAMDDVVEQDAEEEEAEEGPPLGAIPITDCLFCSHHSSSLMKNVAHMTKDHSFFIPDIEYLSDIKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDKSHCKLFTDGDAALEFADFYDFRSSYPDHKEGEDPNKAEELPSEKNLEYDDETMELILPSGARVGHRSLMRYYKQRFGLSRAVAVAKNRKAVGRVLQQYRALGWTGSTGAALMRERDMQYVQRMKSKWMLKTGMKNNATKQMHFRVQVRF", "length": 477 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VX08-1", "protein_name": "C2H2-type domain-containing protein", "gene_name": "Dmel\\CG6769", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSHFTCLNCDARFASADVQRNHYKTDWHRYNLKRRVAQLPPVTAEEFQQRVLSARSATDAALEEQNLSVYCHACRRQFASQKAHDNHLNSRKHKELLARFEREQMTASGGSASTATSVCTRSVVEQRPHPALAAAAAGKGRLAFAERVVKANNDEEMVDEDDDDFEDIEEEEVDSDEWDKIPENPLTERDCLFCTHASEDLVENLKHMSVAHSFFIPDTEYCTDIEGLLYYLGEKVANYFICLFCNDRGKTFYSLDAVRKHMIDKGHCQMLHEGVALAEYAEYYDYSSSYPDNNEGMDIDEEVVPDLLDGDEYQLVLPSGAVIGHRSLLRYYKQRLRPERAVVIKKSDRKLHRVLSEYRALGWTQTQQLSAARKARDIHLMKRVQSKWQMKLGCKANKLQKHYRAQVLI", "length": 409 }, "evidence": [ { "id": "F1N194", "url": "https://omabrowser.org/oma/group/F1N194/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "preribosome binding", "id": "GO:1990275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990275", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "preribosome, large subunit precursor", "id": "GO:0030687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030687", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to oxidative stress", "id": "GO:0008631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008631", "evidence": [ { "database": "UniProtKB", "id": "F1N194", "url": "https://www.uniprot.org/uniprotkb/F1N194" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N194-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 506, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N194-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N194" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N194" }, { "id": "PS00028", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 127, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 493, "end_pos": 495 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAV2-1", "uniprot_ac": "E1BAV2", "uniprot_id": "E1BAV2_BOVIN", "mass": { "chemical_mass": 118589.0, "monoisotopic_mass": 118589.0 }, "refseq": { "ac": "NP_001070362", "name": "probable E3 ubiquitin-protein ligase HERC4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070362" }, "gene_names": [ { "name": "HERC4", "type": "recommended", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "name": "HERC4", "type": "synonym", "evidence": [ { "id": "NP_001070362", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070362" } ] } ], "protein_names": [ { "name": "Probable E3 ubiquitin-protein ligase HERC4", "type": "recommended", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.26", "type": "synonym", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2/entry#names_and_taxonomy" } ] }, { "name": "HECT domain and RCC1-like domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2/entry#names_and_taxonomy" } ] }, { "name": "HECT-type E3 ubiquitin transferase HERC4", "type": "synonym", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2/entry#names_and_taxonomy" } ] }, { "name": "hect domain and RLD 4", "type": "synonym", "evidence": [ { "id": "NP_001070362", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070362" } ] }, { "name": "probable E3 ubiquitin-protein ligase HERC4", "type": "synonym", "evidence": [ { "id": "NP_001070362", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070362" } ] } ], "function": [ { "annotation": "Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2#function" }, { "database": "UniProtKB", "id": "ARBA00054628", "url": "https://www.uniprot.org/uniprotkb/ARBA00054628#function" }, { "database": "UniProtKB", "id": "A0A3Q1LYN7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN7#function" }, { "database": "UniProtKB", "id": "A0ABI0NN46", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN46#function" }, { "database": "UniProtKB", "id": "A0A3Q1LS42", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS42#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HERC4", "url": "https://www.uniprot.org/uniprotkb/E1BAV2", "locus": { "chromosome": "28", "start_pos": 24437054, "end_pos": 24564520, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014029", "url": "https://www.ensembl.org/id/ENSBTAG00000014029" } ] } } ], "crossref": [ { "id": "E1BAV2", "url": "https://alphafold.ebi.ac.uk/entry/E1BAV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014029", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014029", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533336", "url": "https://www.ncbi.nlm.nih.gov/gene/533336", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533336", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533336", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FKSQACW", "url": "https://omabrowser.org/oma/group/FKSQACW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LS42", "url": "https://www.orthodb.org/?gene=A0A3Q1LS42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAV2", "url": "https://www.orthodb.org/?gene=E1BAV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45622", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45622", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45622:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45622:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070362", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS42", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS42-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYN7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NN46", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NN46-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAV2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 1057, "header": "tr|E1BAV2-1|E1BAV2_BOVIN Isoform 1 of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=2 CANONICAL=E1BAV2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS42-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS42/entry", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPSCLPKIMGIDTLVRTCSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 1081, "header": "tr|A0A3Q1LS42-1|A0A3Q1LS42_BOVIN Computationally mapped isoform of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=2 CANONICAL=E1BAV2-1" }, "locus": { "chromosome": "28", "start_pos": 24562266, "end_pos": 24437391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069473.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069473.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059836.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059836.2" } ] } }, { "isoform_ac": "A0A3Q1LYN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN7/entry", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPSCLPKIMGIDTLVRTCSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 1073, "header": "tr|A0A3Q1LYN7-1|E1BAV2_BOVIN Computationally mapped isoform of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=2 CANONICAL=E1BAV2-1" }, "locus": { "chromosome": "28", "start_pos": 24562266, "end_pos": 24437391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060755.2" } ] } }, { "isoform_ac": "A0AAA9SJ33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ33/entry", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 979, "header": "tr|A0AAA9SJ33-1|E1BAV2_BOVIN Computationally mapped isoform of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=1 CANONICAL=E1BAV2-1" }, "locus": { "chromosome": "28", "start_pos": 24562266, "end_pos": 24437391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101461.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101461.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083924.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083924.1" } ] } }, { "isoform_ac": "A0AAA9TY52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY52/entry", "sequence": { "sequence": "MAAQVEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 979, "header": "tr|A0AAA9TY52-1|E1BAV2_BOVIN Computationally mapped isoform of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=1 CANONICAL=E1BAV2-1" }, "locus": { "chromosome": "28", "start_pos": 24557105, "end_pos": 24437391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098927.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098927.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102128.1" } ] } }, { "isoform_ac": "A0ABI0NN46-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN46/entry", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 953, "header": "tr|A0ABI0NN46-1|A0ABI0NN46_BOVIN Computationally mapped isoform of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=1 CANONICAL=E1BAV2-1" }, "locus": { "chromosome": "28", "start_pos": 24562266, "end_pos": 24437391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153633.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153633.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104182.1" } ] } }, { "isoform_ac": "E1BAV2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAV2/entry", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLLGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQASPQLIKSLLGIPFMQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRTQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFPYNGQCPPDFDSEEYFCVKRIFSGGDQSFSHYSNPQNCGPPDDFRYPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQIAQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKSGQIIQYDKFYIHEVQELIDIRNDYIIWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLILVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI", "length": 1057, "header": "tr|E1BAV2-1|E1BAV2_BOVIN Isoform 1 of Probable E3 ubiquitin-protein ligase HERC4 OS=Bos taurus OX=9913 GN=HERC4 PE=4 SV=2 CANONICAL=E1BAV2-1" }, "locus": { "chromosome": "28", "start_pos": 24562266, "end_pos": 24437391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018639.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018639.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018639.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018639.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:533336", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533336", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LZF6-1", "protein_name": "Probable E3 ubiquitin-protein ligase HERC4", "gene_name": "Herc4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLCWGNASYGQLGLGGIDEEIVLEPRKSDFFANKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYSWGLDSDGQLGLLGSEEYIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCKKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIDSEDCFCVKRIFSGGDQSFSHYSNPQSCGPADDFRCPDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLATSNDDHYRTGTKFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHEVQDLIDIRNDYINWVQQQAYGVDVSHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKSIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFQYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVVNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGDYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGENYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI", "length": 1057 }, "evidence": [ { "id": "E1BAV2", "url": "https://omabrowser.org/oma/group/E1BAV2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZSA3-1", "protein_name": "HECT-type E3 ubiquitin transferase", "gene_name": "HERC4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFLNKRIRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKARKRPEHVGALDAQNIVAVSCGEAHTLALNDKGQVYAWGLATDGQLGLPGTEECIRVPRNIKSLSEIQIVQVACGYYHSLALSKGSEVFSWGQNKYGQLGLGYEYKKQNSPHVIKSLLGIPFAQIAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDDNDRYVPTLLKSLRTQKVVHICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSLVTQITCGRQHTTAFVPSSGRIYSFGLGGNGQLGTGTTSNRKSPFTVKGNWLPYSTQCLIPADSEQYYCVKRIFSGGDQSFAHYFYPQNMVPPDDFRYPDLLKQIWTVNETFIQRLLTFPSGRLPVEIANEIDGTFSSAGCLNGSFLALSNDDHYKTSVRFSGVDMNAARLLFHKLIQPDHAHISQQVAASLEKNLIPKLSSSLPDVEALRLYLTLPECPLMSDANNFTTLAIPFGTAILKLEKAPLKVLENWWSVLEPPLFLKIVELYKDVVVHLLKLYKIGIPPSERRIFTNFLHTAFRVLEILHRVNERGQVIQYDRFYIHEIQDLIDIRNDYVNWVQQQVFGMDVNHGLTELTDMPVTICTYPFVFDAQAKTTLLQTDAVMQMQMAVDQAHRQNLSSLFLPVFESVNPCLILMVRRDNIVGDAVEVLRKTKNVDYKKPLKVIFVGEEAVDVGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTFEDSDLFHLIGVVCGLAIYNFTIVDLHFPLALYKKLLNKKPSLDDLKELMPDVGRGMQQLLDYPEDDIEEAFCLNFTITVENFGTTEIKELVPNGADIPVVKHNRQDFVDAYVDYIFNKSVASLFSAFHAGFHKVCGGKVLQLFQPSELQSMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHQLPLEKKKQFLLFLTGSDRIPILGMKCLKLVIQPTGGGEGYLPVAHTCFNLLDLPKYTDKETLKSKLIQAIDHYEGFSLV", "length": 1056 }, "evidence": [ { "id": "E1BAV2", "url": "https://omabrowser.org/oma/group/E1BAV2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5GLZ8-1", "protein_name": "Probable E3 ubiquitin-protein ligase HERC4", "gene_name": "HERC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI", "length": 1057 }, "evidence": [ { "id": "E1BAV2", "url": "https://omabrowser.org/oma/group/E1BAV2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5PQN1-1", "protein_name": "Probable E3 ubiquitin-protein ligase HERC4", "gene_name": "Herc4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLCWGNASYGQLGLGGIDEEIVLEPRKSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIECQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQSCGPPDDFRRSDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHRLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNERTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGITELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI", "length": 1057 }, "evidence": [ { "id": "E1BAV2", "url": "https://omabrowser.org/oma/group/E1BAV2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PAV2-1", "protein_name": "Probable E3 ubiquitin-protein ligase HERC4", "gene_name": "Herc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCSDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAISNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGVTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI", "length": 1057 }, "evidence": [ { "id": "E1BAV2", "url": "https://omabrowser.org/oma/group/E1BAV2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" }, { "name": "negative regulation of smoothened signaling pathway", "id": "GO:0045879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045879", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "E1BAV2", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 693, "end_pos": 695, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" }, { "start_pos": 863, "end_pos": 865, "annotation": "n_glycosylation_sequon" }, { "start_pos": 906, "end_pos": 908, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 730, "end_pos": 1057, "start_aa": "Lys", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.26", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.26" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 693, "end_pos": 695 }, { "start_pos": 6, "end_pos": 8 }, { "start_pos": 808, "end_pos": 810 }, { "start_pos": 863, "end_pos": 865 }, { "start_pos": 906, "end_pos": 908 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B7V9-1", "uniprot_ac": "E1B7V9", "uniprot_id": "E1B7V9_BOVIN", "mass": { "chemical_mass": 160332.0, "monoisotopic_mass": 160332.0 }, "refseq": { "ac": "XP_002697009", "name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697009" }, "gene_names": [ { "name": "MAGI1", "type": "recommended", "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ] }, { "name": "MAGI1", "type": "synonym", "evidence": [ { "id": "XP_002697009", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697009" } ] } ], "protein_names": [ { "name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9/entry#names_and_taxonomy" } ] }, { "name": "BAI1-associated protein 1", "type": "synonym", "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9/entry#names_and_taxonomy" } ] }, { "name": "Membrane-associated guanylate kinase inverted 1", "type": "synonym", "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9/entry#names_and_taxonomy" } ] }, { "name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23", "type": "synonym", "evidence": [ { "id": "XP_002697009", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697009" } ] } ], "function": [ { "annotation": "Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY14#function" }, { "database": "UniProtKB", "id": "ARBA00058771", "url": "https://www.uniprot.org/uniprotkb/ARBA00058771#function" }, { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9#function" }, { "database": "UniProtKB", "id": "A0A3Q1MD62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD62#function" }, { "database": "UniProtKB", "id": "A0A3Q1MRR4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR4#function" }, { "database": "UniProtKB", "id": "A0A3Q1MP82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP82#function" }, { "database": "UniProtKB", "id": "A0A3Q1MST4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MST4#function" }, { "database": "UniProtKB", "id": "A0ABI0NQ75", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ75#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAGI1", "url": "https://www.uniprot.org/uniprotkb/E1B7V9", "locus": { "chromosome": "22", "start_pos": 36021215, "end_pos": 35381753, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010581", "url": "https://www.ensembl.org/id/ENSBTAG00000010581" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010581", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010581", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06730", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06730", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06731", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06731", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06732", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06732", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06733", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06733", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06734", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06734", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06735", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06735", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783484", "url": "https://www.ncbi.nlm.nih.gov/gene/783484", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783484", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783484", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10316", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10316", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10316:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10316:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16666", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16666", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697009", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697009", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD62-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRR4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MST4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MST4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MST4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MST4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ75", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ75-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7V9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVTATEAAGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPGSDGNGPPTGPQGVPEMRAGPPDRRQHPSLESSYPPDLHKSSPHGEKRAHVRDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREKQEKRKEVSPERRRERSPTRRRDGSPGRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTKSPERRRERSLEKRNKEDRGSHRERDETSLRQDTGRSSRHPPEQRRRPYKECSTDLSI", "length": 1454, "header": "tr|E1B7V9-1|E1B7V9_BOVIN Isoform 1 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=4 CANONICAL=E1B7V9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY14/entry", "sequence": { "sequence": "MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVTATEAAGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPGSDGNGPPTGPQGVPEMRAGPPDRRQHPSLESSYPPDLHKSSPHGEKRAHVRDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREKQEKRKEVSPERRRERSPTRRRDGSPGRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTKSPERRRERSLEKRNKEDRGSHRERDETSLRQDTGRSSRHPPEQRRRPYKECSTDLSI", "length": 1482, "header": "tr|A0A3Q1LY14-1|A0A3Q1LY14_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=2 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36020211, "end_pos": 35381952, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070813.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070813.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062159.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062159.2" } ] } }, { "isoform_ac": "A0A3Q1MD62-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD62/entry", "sequence": { "sequence": "MLGRIEGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPGSDGNGPPTGPQGVPEMRAGPPDRRQHPSLESSYPPDLHKSSPHGEKRAHVRDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREKQEKRKEVSPERRRERSPTRRRDGSPGRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTKSPERRRERSLEKRNKEDRGSHRERDETSLRQDTGRSSRHPPEQRRRPYKECSTDLSI", "length": 1356, "header": "tr|A0A3Q1MD62-1|E1B7V9_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=2 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36020211, "end_pos": 35558859, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074262.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074262.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068336.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068336.2" } ] } }, { "isoform_ac": "A0A3Q1MP82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP82/entry", "sequence": { "sequence": "MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVTATEAAGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPGSDGNGPPTGPQGVPEMRAGPPDRRQHPSLESSYPPDLHKSSPHGEKRAHVRDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREKQEKRKEVSPERRRERSPTRRRDGSPGRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTKSPERRRERSLEKRNKEDRGSHRERDETSLRQDTGRSSRHPPEQRRRPYKECSTDLSI", "length": 1415, "header": "tr|A0A3Q1MP82-1|E1B7V9_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=2 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36020211, "end_pos": 35381952, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070056.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070056.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073211.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073211.2" } ] } }, { "isoform_ac": "A0A3Q1MRR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR4/entry", "sequence": { "sequence": "MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVTATEAAGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPGSDGNGPPTGPQGVPEMRAGPPDRRQHPSLESSYPPDLHKSSPHGEKRAHVRDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREKQEKRKEVSPERRRERSPTRRRDGSPGRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTKSPERRRERSLEKRNKEDRGSHRERDETSLRQDTGRSSRHPPEQRRRPYKECSTDLSI", "length": 1470, "header": "tr|A0A3Q1MRR4-1|E1B7V9_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=2 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36020211, "end_pos": 35381952, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071245.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071245.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072556.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072556.2" } ] } }, { "isoform_ac": "A0A3Q1MST4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MST4/entry", "sequence": { "sequence": "MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVTATEAAGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACFYLMGHNQTTTPAATGTAPPPVHKVFRK", "length": 1279, "header": "tr|A0A3Q1MST4-1|E1B7V9_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=2 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36019513, "end_pos": 35381952, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077975.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077975.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073189.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073189.2" } ] } }, { "isoform_ac": "A0ABI0NQ75-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ75/entry", "sequence": { "sequence": "MQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACFYLMGHNQTTTPAATGTAPPPVHKVFRK", "length": 1052, "header": "tr|A0ABI0NQ75-1|A0ABI0NQ75_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=1 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36019513, "end_pos": 35905517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136545.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136545.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105433.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105433.1" } ] } }, { "isoform_ac": "E1B7V9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V9/entry", "sequence": { "sequence": "MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAENGEFPYVGAVTATEAAGLPGGGEGPRLGEGELLLEVQGIRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGKLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALQNLHSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGDQEEHSLQEAAHPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGIHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQPEEWTEDHSSLVPPAIPNHPPSNPEPAREAPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNGSHGYPTDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVASHRSLHTASPSHSTQVLPELPPAEAPAPDQTDNSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAAPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGAQETRNTTKPKPESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMKVGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPGSDGNGPPTGPQGVPEMRAGPPDRRQHPSLESSYPPDLHKSSPHGEKRAHVRDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQPERMVTNGPKRRSPEKRREGTRSADNTLERREKQEKRKEVSPERRRERSPTRRRDGSPGRRRRSLERLLDQRRSPERKRGSSPERRAKSTDRRRTKSPERRRERSLEKRNKEDRGSHRERDETSLRQDTGRSSRHPPEQRRRPYKECSTDLSI", "length": 1454, "header": "tr|E1B7V9-1|E1B7V9_BOVIN Isoform 1 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Bos taurus OX=9913 GN=MAGI1 PE=4 SV=4 CANONICAL=E1B7V9-1" }, "locus": { "chromosome": "22", "start_pos": 36020211, "end_pos": 35381952, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013997.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013997.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013997.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013997.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783484", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783484", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of cell-cell adhesion", "id": "GO:0022409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022409", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "alpha-actinin binding", "id": "GO:0051393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051393", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7V9", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1032, "end_pos": 1034, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1090, "end_pos": 1092, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1276, "end_pos": 1278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" }, { "start_pos": 558, "end_pos": 560, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" }, { "start_pos": 735, "end_pos": 737, "annotation": "n_glycosylation_sequon" }, { "start_pos": 882, "end_pos": 884, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 189, "start_aa": "Ala", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 105, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1B7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V9" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 300, "end_pos": 333, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1032, "end_pos": 1034 }, { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 1090, "end_pos": 1092 }, { "start_pos": 1276, "end_pos": 1278 }, { "start_pos": 248, "end_pos": 250 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 515, "end_pos": 517 }, { "start_pos": 558, "end_pos": 560 }, { "start_pos": 611, "end_pos": 613 }, { "start_pos": 735, "end_pos": 737 }, { "start_pos": 882, "end_pos": 884 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BAW4-1", "uniprot_ac": "E1BAW4", "uniprot_id": "E1BAW4_BOVIN", "mass": { "chemical_mass": 67960.0, "monoisotopic_mass": 67960.0 }, "refseq": { "ac": "NP_001179239", "name": "rhotekin-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179239" }, "gene_names": [ { "name": "RTKN2", "type": "recommended", "evidence": [ { "id": "E1BAW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ] }, { "name": "RTKN2", "type": "synonym", "evidence": [ { "id": "NP_001179239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179239" } ] } ], "protein_names": [ { "name": "Rhotekin-2", "type": "recommended", "evidence": [ { "id": "E1BAW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW4/entry#names_and_taxonomy" } ] }, { "name": "Pleckstrin homology domain-containing family K member 1", "type": "synonym", "evidence": [ { "id": "E1BAW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW4/entry#names_and_taxonomy" } ] }, { "name": "rhotekin-2", "type": "synonym", "evidence": [ { "id": "NP_001179239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179239" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTKN2", "url": "https://www.uniprot.org/uniprotkb/E1BAW4", "locus": { "chromosome": "28", "start_pos": 18283768, "end_pos": 18393795, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014020", "url": "https://www.ensembl.org/id/ENSBTAG00000014020" } ] } } ], "crossref": [ { "id": "E1BAW4", "url": "https://alphafold.ebi.ac.uk/entry/E1BAW4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014020", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014020", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13249", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13249", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539797", "url": "https://www.ncbi.nlm.nih.gov/gene/539797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539797", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GNHKMVI", "url": "https://omabrowser.org/oma/group/GNHKMVI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZS8", "url": "https://www.orthodb.org/?gene=A0A3Q1LZS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAW4", "url": "https://www.orthodb.org/?gene=E1BAW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21538", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21538", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21538:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21538:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179239", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZS8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZS8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAW4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAW4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERHLLRGHELRAAGPAAQQNCSIQEKMDLEIRIREGIWKLLSLSTQKGQILQAVKNLMVCNARIMAYTLELQKLEEQIANQAGKCENFESKERTACRGKIAISDIRIPLMWKDSDHFSNKERSQHYAIFCLFKLGAEVFDTEMVIVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEASSITNTPKKLAKKLKTSISKATGKKISSVLQEDHEITCLSFSSSIYDAKYSLLAHTTLSLESAEDGFKTHNLSVNGNEESSFWLPLYGNMCCRLVAQPTCMAEDVFVGFLNEQQMVGGLIRWRRLYCVLRGGKLYCFYTPEEIEAKVEPALIVSINKETRIRAVDKDKTKRINNFSVINPVAGQAETHIFSADNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTGIIQKKIEETNGEFLVGQHEESSSPSWATLKKVLSPASKQLHEEKGKKRRAPLPPSDKVPFNLKTQSNKNQLVQGNWEKTSVSQTSPLDTKLSTPMHHLQKPVAAPRKLLPARKSSSTDGEHTDTKTSIEAKPVPAPRQKTIKDILDPRSWWWTQV", "length": 598, "header": "tr|E1BAW4-1|E1BAW4_BOVIN Isoform 1 of Rhotekin-2 OS=Bos taurus OX=9913 GN=RTKN2 PE=4 SV=3 CANONICAL=E1BAW4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZS8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS8/entry", "sequence": { "sequence": "MSDSETPWTAACQTSLSITQLPKLGQTRVHRNCSIQEKMDLEIRIREGIWKLLSLSTQKGQILQAVKNLMVCNARIMAYTLELQKLEEQIANQAGKCENFESKERTACRGKIAISDIRIPLMWKDSDHFSNKERSQHYAIFCLFKLGAEVFDTEMVIVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEASSITNTPKKLAKKLKTSISKATGKKISSVLQEDHEITCLSFSSSIYDAKYSLLAHTTLSLESAEDGFKTHNLSVNGNEESSFWLPLYGNMCCRLVAQPTCMAEDVFVGFLNEQQMVGGLIRWRRLYCVLRGGKLYCFYTPEEIEAKVEPALIVSINKETRIRAVDKDKTKRINNFSVINPVAGQAETHIFSADNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTGIIQKKIEETNGEFLVGQHEESSSPSWATLKKVLSPASKQLHEEKGKKRRAPLPPSDKVPFNLKTQSNKNQLVQGNWEKTSVSQTSPLDTKLSTPMHHLQKPVAAPRKLLPARKSSSTDGEHTDTKTSIEAKPVPAPRQKTIKDILDPRSWWWTQV", "length": 609, "header": "tr|A0A3Q1LZS8-1|A0A3Q1LZS8_BOVIN Computationally mapped isoform of Rhotekin-2 OS=Bos taurus OX=9913 GN=RTKN2 PE=4 SV=2 CANONICAL=E1BAW4-1" }, "locus": { "chromosome": "28", "start_pos": 18388974, "end_pos": 18284772, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071700.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071700.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063158.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063158.2" } ] } }, { "isoform_ac": "E1BAW4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAW4/entry", "sequence": { "sequence": "MERHLLRGHELRAAGPAAQQNCSIQEKMDLEIRIREGIWKLLSLSTQKGQILQAVKNLMVCNARIMAYTLELQKLEEQIANQAGKCENFESKERTACRGKIAISDIRIPLMWKDSDHFSNKERSQHYAIFCLFKLGAEVFDTEMVIVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEASSITNTPKKLAKKLKTSISKATGKKISSVLQEDHEITCLSFSSSIYDAKYSLLAHTTLSLESAEDGFKTHNLSVNGNEESSFWLPLYGNMCCRLVAQPTCMAEDVFVGFLNEQQMVGGLIRWRRLYCVLRGGKLYCFYTPEEIEAKVEPALIVSINKETRIRAVDKDKTKRINNFSVINPVAGQAETHIFSADNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTGIIQKKIEETNGEFLVGQHEESSSPSWATLKKVLSPASKQLHEEKGKKRRAPLPPSDKVPFNLKTQSNKNQLVQGNWEKTSVSQTSPLDTKLSTPMHHLQKPVAAPRKLLPARKSSSTDGEHTDTKTSIEAKPVPAPRQKTIKDILDPRSWWWTQV", "length": 598, "header": "tr|E1BAW4-1|E1BAW4_BOVIN Isoform 1 of Rhotekin-2 OS=Bos taurus OX=9913 GN=RTKN2 PE=4 SV=3 CANONICAL=E1BAW4-1" }, "locus": { "chromosome": "28", "start_pos": 18393694, "end_pos": 18284772, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018637.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018637.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018637.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018637.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZWI9-1", "protein_name": "Rhotekin-2", "gene_name": "RTKN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGQTLRGSELRPAGLSAQQDNGIQEKINLEIRIREGIWKLLSLSTQKDQVLHAVKNLMVCNARIMAYTLELQKIEEQTADQTRRCDVDFEHKARTACKGKIAISDIRIPLMWKDSDHFSNKERSQRYAIFCLFKMGAEVFDSDMVIVDKTITDICFENVTVFNEAGPDFQIKVEVYSCCTEESTITNTPKKLAKKLKTSISKATGKKINSVLQEDHETCLSFSSTISCAKYSLLAHTTLSLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVEGMITWRRLYCVLRGGKLYCFYTPEEIEAKVEPTLIVSINKETRIRAMDKEKKKRIHIFSVINPVAGQAITHIFAADNREDLNKWLEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPLKIESLTDIIQKKIEETNGEFLIGQHEEFSPPPWATLFDGNHQVVIQKKVFPSASKQLHDGKGKKRRAPLPPSDKAPFSLKTQSNTDQLVKDNWEKTSISQTAPLDTKLSTLMHHLQKPMAAPRKLLPARKNSLTDGEHTDTKTRFEAKPVPAPRQKSIKDILDPRSWLQAQV", "length": 608 }, "evidence": [ { "id": "E1BAW4", "url": "https://omabrowser.org/oma/group/E1BAW4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZSI8-1", "protein_name": "Rhotekin 2", "gene_name": "Rtkn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRGCLSFRDPTHWMARDRQQFLPSSTMHTHQDCSIQEKIDLEIRMREGIWKLLSLSKKKDQVLHAVKNLMVCNARMQVYTAELQKLEETASQTGRRDASLETKEQEPCRGKIALSDIRIPLMWKDSDHFGHKECTQRFAIFCLFRMGTQVFDTDMMIVDQTVTDICFENVTIFNEAGPDFRVKIEVYSSSAEESSITNTPKKLAKKLKTSISKATGRKISAVLQEEDQEASLLVSSVAGAKYHLLAHTTLTLENAGDCFKTHNLSVHGDEECSFWLPLYGNLCCRLVAQPACMAEDAFAGFLNEQQTGKGLVGWRRLYCALRGGKLRCFYGPEEIEAKVEPTLVIPVDKETRIQAMEKDSKKMHCFSVLTTAAGRAVSHIFAADGLGDFQEWMDAFRQHRFDLSHWKHCCEELMRIEIMSPRKPPLFLAKEATSVYHDMSIDSPVKLESVTDIIQKKIGETNGQFLIGREEESTTPPWASVFDGSHEMVIQKKVLSPAGKPAPDGKRKKRRAPLPPMDQPPFSVKTQGSMGQSKDSEAQVGVSGAPSSDRRLSPPTHHLQKPVAAPRKLLPTRKSSSEDSGPTDAKTSLDGKPVPAPRQKSIRDILDPRSWLQAQV", "length": 617 }, "evidence": [ { "id": "E1BAW4", "url": "https://omabrowser.org/oma/group/E1BAW4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14B46-1", "protein_name": "Rhotekin-2", "gene_name": "Rtkn2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGQLLRGLAAQQDCSIREKIDLEIRMREGIWKLLSLSTKKDQVLHAVKNLMVCSARIQAYTAELQKSKEEIANQTGARLVLDSSSENKEGESCRGKIALSDIRIPLMWKDSDHFSNKECTQRFAIFCLFRMGAQVFDTDMVIVDQTVTDICFENVTIFNEAGPDFQIKIEVYSCSAEESSLTNTPRKLAKKLKTSISKATGRKISAALQEESPEACLLAGSVAGAKYHLLAHTTLTLENAGDCFKTHNLSVHGDEECSFWLPLYGNVCCRLVAQPACMAADAFAGFLNEQQTGKGLVGWRRLYCALRGGKLRCFYGPEEIEAKVEPALVVPIDKETRIQAVEKDSKKMHCFSVLSTAAGRAVSHIFAADSLADFQEWMGAFRQHFFDLSQWKHCCEELMRIEIMSPRKPPLFLAKEATSVYYDMSIDSPVKLESVTDIIQKKIGETNRQFLIGRDDQSAAPPWAAVFDGNHEMVIEKKVLSPIGEPAPDGKRKKRRAPLPPTDQPPFCIKTQGRANQSKDSATQAGVSGASSSPSDPRLSPPTHHLQKPVAAPRKLLPARKNSSADIGHTDTKTSLDAKPVPVPRQKSIRDILDPRSWLQAQV", "length": 604 }, "evidence": [ { "id": "E1BAW4", "url": "https://omabrowser.org/oma/group/E1BAW4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZC4-1", "protein_name": "Rhotekin-2", "gene_name": "RTKN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDDEMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPALVVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV", "length": 609 }, "evidence": [ { "id": "E1BAW4", "url": "https://omabrowser.org/oma/group/E1BAW4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" }, { "name": "hemopoiesis", "id": "GO:0030097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030097", "evidence": [ { "database": "UniProtKB", "id": "E1BAW4", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 285, "end_pos": 392, "start_aa": "Glu", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BAW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAW4" }, { "id": "PS51860", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51860" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "REM-1", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 81, "start_aa": "His", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 21, "end_pos": 23 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 356, "end_pos": 358 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BCC7-1", "uniprot_ac": "E1BCC7", "uniprot_id": "E1BCC7_BOVIN", "mass": { "chemical_mass": 93642.0, "monoisotopic_mass": 93642.0 }, "refseq": {}, "gene_names": [ { "name": "GPR155", "type": "recommended", "evidence": [ { "id": "E1BCC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 155", "type": "synonym", "evidence": [ { "id": "E1BCC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR155", "url": "https://www.uniprot.org/uniprotkb/E1BCC7", "locus": { "chromosome": "2", "start_pos": 22359579, "end_pos": 22323337, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021636", "url": "https://www.ensembl.org/id/ENSBTAG00000021636" } ] } } ], "crossref": [ { "id": "E1BCC7", "url": "https://alphafold.ebi.ac.uk/entry/E1BCC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021636", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021636", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04443", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04443", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538798", "url": "https://www.ncbi.nlm.nih.gov/gene/538798", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538798", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538798", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RISMCRR", "url": "https://omabrowser.org/oma/group/RISMCRR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3Q0", "url": "https://www.orthodb.org/?gene=A0A3Q1M3Q0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCC7", "url": "https://www.orthodb.org/?gene=E1BCC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03547", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03547", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M3Q0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSFSDIPAKNLTFAVNMTKTLSSPVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFVVCILTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKVKILGLGLLRVLQNPIVFMVFIGIAFNFILDQKVPEYMENFLDGLANSFSGSALFYLGLTMVGKIKKLKKSAFVVLILLITAKLLVLPLLCREMVELLDKDDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIISLVSLSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLVTGKHNGESIDSAFFYGKEQMIITAVTLFCSIVIAGISLMCMNRTSQAGRYEGFDQSQDRKAAEPGNTAFEDSPVPVNEPESFTSSVPETSCCSCSMGNGELCCPSTEPVADITTSGSVTPSFEKNEHCVSRCNSQSCILAQEEEQYLHSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNSKETAENKDSSVPEEIKMTCQQFIHYHRDLCIQNIVKERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPKQSPPTINADIPQQEKYKEIEHSSPSPKT", "length": 841, "header": "tr|E1BCC7-1|E1BCC7_BOVIN Isoform 1 of G protein-coupled receptor 155 OS=Bos taurus OX=9913 GN=GPR155 PE=4 SV=3 CANONICAL=E1BCC7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Q0/entry", "sequence": { "sequence": "MNSFSDIPAKNLTFAVNMTKTLSSPVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFVVCILTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKVKILGLGLLRVLQNPIVFMVFIGIAFNFILDQKVPEYMENFLDGLANSFSGSALFYLGLTMVGKIKKLKKSAFVVLILLITAKLLVLPLLCREMVELLDKDDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIISLVSLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLVTGKHNGESIDSAFFYGKEQMIITAVTLFCSIVIAGISLMCMNRTSQAGRYEGFDQSQDRKAAEPGNTAFEDSPVPVNEPESFTSSVPETSCCSCSMGNGELCCPSTEPVADITTSGSVTPSFEKNEHCVSRCNSQSCILAQEEEQYLHSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNSKETAENKDSSVPEEIKMTCQQFIHYHRDLCIQNIVKERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPKQSPPTINADIPQQEKYKEIEHSSPSPKT", "length": 869, "header": "tr|A0A3Q1M3Q0-1|A0A3Q1M3Q0_BOVIN Computationally mapped isoform of G protein-coupled receptor 155 OS=Bos taurus OX=9913 GN=GPR155 PE=4 SV=1 CANONICAL=E1BCC7-1" }, "locus": { "chromosome": "2", "start_pos": 22358575, "end_pos": 22323828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078829.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078829.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068155.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068155.1" } ] } }, { "isoform_ac": "E1BCC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC7/entry", "sequence": { "sequence": "MNSFSDIPAKNLTFAVNMTKTLSSPVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFVVCILTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKVKILGLGLLRVLQNPIVFMVFIGIAFNFILDQKVPEYMENFLDGLANSFSGSALFYLGLTMVGKIKKLKKSAFVVLILLITAKLLVLPLLCREMVELLDKDDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIISLVSLSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLVTGKHNGESIDSAFFYGKEQMIITAVTLFCSIVIAGISLMCMNRTSQAGRYEGFDQSQDRKAAEPGNTAFEDSPVPVNEPESFTSSVPETSCCSCSMGNGELCCPSTEPVADITTSGSVTPSFEKNEHCVSRCNSQSCILAQEEEQYLHSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNSKETAENKDSSVPEEIKMTCQQFIHYHRDLCIQNIVKERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPKQSPPTINADIPQQEKYKEIEHSSPSPKT", "length": 841, "header": "tr|E1BCC7-1|E1BCC7_BOVIN Isoform 1 of G protein-coupled receptor 155 OS=Bos taurus OX=9913 GN=GPR155 PE=4 SV=3 CANONICAL=E1BCC7-1" }, "locus": { "chromosome": "2", "start_pos": 22358575, "end_pos": 22323828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028831.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028831.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028831.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028831.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 594, "start_aa": "Thr", "end_pos": 594, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr594", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538798", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538798", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M5S7-1", "protein_name": "Integral membrane protein GPR155 isoform X1", "gene_name": "Gpr155", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDSYFSAENSTLAINMNETLSATVTHGFNSTSDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLYSILIGKASVFFTVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKVKIVGLGFLHVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIKRLKKSAFVMLTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLAVLLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESMQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSIVIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPASTAFEESQAPTNEPELFPSSIPERSCCSCSLGNGDLCCPSTEPVMNASASGPMPSSIEKTDHCVSRCDSQSCILAQEEELYLQTGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKETAENRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGTKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPQQSPPAVTVSNPQQVGYKESGHSSPSSLSPKT", "length": 870 }, "evidence": [ { "id": "E1BCC7", "url": "https://omabrowser.org/oma/group/E1BCC7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2AWR3-1", "protein_name": "Lysosomal cholesterol signaling protein", "gene_name": "Gpr155", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSYFSAKNSTLAGDMNATWPASHGFNATGDPPSMSITRLFPALLECFGIVLCGYIAGRANIITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLYSVLIGKASVFFIVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQSTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVVLTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLSILLLSKKYKQLPHMLTANLLIAQTIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQLPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPGSTAFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKTDHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPARTLRDHQEESYKEIGHSSPPSVSPKT", "length": 868 }, "evidence": [ { "id": "E1BCC7", "url": "https://omabrowser.org/oma/group/E1BCC7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZWM3-1", "protein_name": "G protein-coupled receptor 155", "gene_name": "Gpr155", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSYFPAKNSTLAVNMNETLSASHGFNSTSDPPPMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFANVDWAFLYSILIGKASVFFVVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTRNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVALIVLITAKLLVLPLLCREMVEVLDKGNSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLSVLLLSKKYKQLPHMLTANLLIAQTIVCAGMVIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQIPVGLIIISGWGIPALLVGVLLITGKHNGDSVDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQSHKPVEPGSTAFEESPAPTSEPELFPSSIPETGCCSCSLGNGELRCPSIQPGTNSSASRPRPSSFEKTDQCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKETAEDRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPERSPPAGTVSNPPEESYKEIGHASPPSLSPKT", "length": 868 }, "evidence": [ { "id": "E1BCC7", "url": "https://omabrowser.org/oma/group/E1BCC7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M9PFK5-1", "protein_name": "Anchor, isoform B", "gene_name": "anchor", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDSSMYYASQRIAASTEANVRVITSTMASSLANGTATPRADDGGVSMNNFYPALVQCFGIIICGYIAGRFKIISNAETKGLGTFVGTFALPSLIFLSLVELNWSAVNWSFLLAMLVSKAVVFFAVLIISLLVARPLNYARGGLMAIFCTQSNDFAIGYPIVMALYKDVHPEYASYLYLMAPISLAILNPVGLVLMEISKIIKNKEDVTRNPPLCPETCPAEQMSKRNRCLGERSILVFNTLIALFFNPLLLMTLLGVAGGFLFPNGLPEMVSSTLRVLGQSFSATALFLLGLKIVGGTGSERKSIGFLLPGVLILVKILVLPLVIRQTVNIMQSGQNFNDTTELSTFGFLYGTFPAAPGAFVIATQYNMEVELVARSMVFCTFISAPLMFISAKMISLTNLKPLDYLHELDAFSFDISVAGAAACCIMLALLIVTKRFKRMPQRITFCLVLSQLMCCIGVILWSKMEHVHRWPLYLQFLLFNIGTYSTRLWTGLLAISLLFLQCRSLCFVLKLWPYMLVFAWGVPAVLSALLIAFDSNVMSGEKHNPSFQYGNAQAAISVFMLVMCFIVTVGCLVLHQRYKKRYEKYMTYSRELSNPESESSDLHSTISTTNLLSHTDQSSIRQSVRTASYSSSSDDEEMIPTAAGLPTSRSNGAASGGAGSGGGGCGSGNGTCCSGGAPVSNSSTTSTVVVDIEDLLNRTRQRASGANNKDLNKIESAPATEEIRNQMCSSSFNCGPSTSRQSCQTIIERYEDQNRRGLEPLEHPSDADEHQTLKHTVLLITLLCSMFVGLAVSIWTLVMEGMSGIYLELSFLDAFLNFGQGLIVLAVFITDIGELLMPVVKLWRKLWYGANVVSLPHWSNVRPETKHICEQFRNHHLENCKKDIAKDRRWRIRVYRRVFYGTEFVSWLIEVGLSKDRMEAVHYARHLVDGRVLRHINNVYHFEDKLLLYNFCSRI", "length": 957 }, "evidence": [ { "id": "E1BCC7", "url": "https://omabrowser.org/oma/group/E1BCC7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q7Z3F1-1", "protein_name": "Lysosomal cholesterol signaling protein", "gene_name": "GPR155", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHKVVEPGNTAFEESPAPVNEPELFTSSIPETSCCSCSMGNGELHCPSIEPIANTSTSEPVIPSFEKNNHCVSRCNSQSCILAQEEEQYLQSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKDTAENRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPAINANTLQQERYKEIEHSSPPSHSPKT", "length": 870 }, "evidence": [ { "id": "E1BCC7", "url": "https://omabrowser.org/oma/group/E1BCC7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "cognition", "id": "GO:0050890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050890", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "cellular response to cholesterol", "id": "GO:0071397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071397", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "E1BCC7", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 517, "end_pos": 519, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC7" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 741, "end_pos": 809, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 594 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 17, "end_pos": 19 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 517, "end_pos": 519 }, { "start_pos": 646, "end_pos": 648 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N151-1", "uniprot_ac": "F1N151", "uniprot_id": "F1N151_BOVIN", "mass": { "chemical_mass": 91222.0, "monoisotopic_mass": 91222.0 }, "refseq": {}, "gene_names": [ { "name": "DNAJC10", "type": "recommended", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 10", "type": "recommended", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151/entry#names_and_taxonomy" } ] }, { "name": "1.8.4.-", "type": "synonym", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Endoplasmic reticulum disulfide reductase that collaborates directly with a BIP/HSPA5 (GRP78)-type chaperone to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins.", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151#function" }, { "database": "UniProtKB", "id": "PIRNR037293", "url": "https://www.uniprot.org/uniprotkb/PIRNR037293#function" } ] }, { "annotation": "Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151#function" }, { "database": "UniProtKB", "id": "ARBA00094198", "url": "https://www.uniprot.org/uniprotkb/ARBA00094198#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC10", "url": "https://www.uniprot.org/uniprotkb/F1N151", "locus": { "chromosome": "2", "start_pos": 13794137, "end_pos": 13842064, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008390", "url": "https://www.ensembl.org/id/ENSBTAG00000008390" } ] } } ], "crossref": [ { "id": "F1N151", "url": "https://alphafold.ebi.ac.uk/entry/F1N151", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008390", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008390", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03003", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03003", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03004", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03004", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "APTWRKF", "url": "https://omabrowser.org/oma/group/APTWRKF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N151", "url": "https://www.orthodb.org/?gene=F1N151", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44340:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44340:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "21064", "url": "https://www.rhea-db.org/rhea/21064", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RT35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7F9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7F9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7F9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N151-1", "url": "https://www.uniprot.org/uniprotkb/F1N151-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLDGLVNVGWVDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKSGILFLSSLDAKEIYLEIMHNLPDFELLSANSLQDRLAHHRWLLFFQFGQNENSNDPELKKLKTLLKNEHIQIGKFDCSSAPDVCSNFYVFQPCLAVFKGQGTKEFEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCQALLPELRKASKHLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRLYPYERAKRNTWGEQIDSRDAKEIATLIYEKLEKLQNHEKRDKDEL", "length": 793, "header": "tr|F1N151-1|F1N151_BOVIN Isoform 1 of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN=DNAJC10 PE=4 SV=1 CANONICAL=F1N151-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RT35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT35/entry", "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSGKKILYDILAFAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCQALLPELRKASKHLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRLYPYERAKRNTWGEQIDSRDAKEIATLIYEKLEKLQNHEKRDKDEL", "length": 626, "header": "tr|A0AAA9RT35-1|F1N151_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN=DNAJC10 PE=4 SV=1 CANONICAL=F1N151-1" }, "locus": { "chromosome": "2", "start_pos": 13840181, "end_pos": 13794251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091916.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091916.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074923.1" } ] } }, { "isoform_ac": "A0AAA9T7F9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7F9/entry", "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLDGLVNVGWVDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKSGILLLP", "length": 332, "header": "tr|A0AAA9T7F9-1|F1N151_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN=DNAJC10 PE=4 SV=1 CANONICAL=F1N151-1" }, "locus": { "chromosome": "2", "start_pos": 13840181, "end_pos": 13820134, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093592.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093592.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094684.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094684.1" } ] } }, { "isoform_ac": "A0AAA9TBB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB8/entry", "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLFLSSLDAKEIYLEIMHNLPDFELLSANSLQDRLAHHRWLLFFQFGQNENSNDPELKKLKTLLKNEHIQIGKFDCSSAPDVCSNFYVFQPCLAVFKGQGTKEFEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCQALLPELRKASKHLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRLYPYERAKRNTWGEQIDSRDAKEIATLIYEKLEKLQNHEKRDKDEL", "length": 747, "header": "tr|A0AAA9TBB8-1|F1N151_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN=DNAJC10 PE=4 SV=1 CANONICAL=F1N151-1" }, "locus": { "chromosome": "2", "start_pos": 13840181, "end_pos": 13794251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093378.1" } ] } }, { "isoform_ac": "F1N151-1", "url": "https://www.uniprot.org/uniprotkb/F1N151/entry", "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLDGLVNVGWVDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKSGILFLSSLDAKEIYLEIMHNLPDFELLSANSLQDRLAHHRWLLFFQFGQNENSNDPELKKLKTLLKNEHIQIGKFDCSSAPDVCSNFYVFQPCLAVFKGQGTKEFEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCQALLPELRKASKHLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRLYPYERAKRNTWGEQIDSRDAKEIATLIYEKLEKLQNHEKRDKDEL", "length": 793, "header": "tr|F1N151-1|F1N151_BOVIN Isoform 1 of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN=DNAJC10 PE=4 SV=1 CANONICAL=F1N151-1" }, "locus": { "chromosome": "2", "start_pos": 13840181, "end_pos": 13794251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011043.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011043.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011043.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011043.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q498R3-1", "protein_name": "Endoplasmic reticulum disulfide reductase DNAJC10", "gene_name": "Dnajc10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVWLNRDEFIRDVKRISLCLLVLYVVIVVGTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGDRSKESLVSFAMQHVRTTVTELSTGNFVNAIETAFAAGIGWLITFCFKGEDCLTPQTRLRLSGMLDGLVNVGWVDCDTQDSLCKSLDATASTTAYFPPGATLNNKEKSSVLFLNSLDAKEIYMEIIHNLPDFELLSANKLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQSCLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSVHEYEGHHSAEQILEFIEDLRNPSVVSLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSRAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNEKVLQGKTHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYPQTCQKAGIRAYPSVKLYLYERAKKSIWEEQINSRDAKTIAALIYGKLETFQSQVKRNKDEL", "length": 793 }, "evidence": [ { "id": "F1N151", "url": "https://omabrowser.org/oma/group/F1N151/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IXB1-1", "protein_name": "Endoplasmic reticulum disulfide reductase DNAJC10", "gene_name": "DNAJC10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGVWLNKDDYIRDLKRIILCFLIVYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWNYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKNSILFLNSLDAKEIYLEVIHNLPDFELLSANTLEDRLAHHRWLLFFHFGKNENSNDPELKKLKTLLKNDHIQVGRFDCSSAPDICSNLYVFQPSLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANDKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFIEDLMNPSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQGKRNKDEL", "length": 793 }, "evidence": [ { "id": "F1N151", "url": "https://omabrowser.org/oma/group/F1N151/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DC23-1", "protein_name": "Endoplasmic reticulum disulfide reductase DNAJC10", "gene_name": "Dnajc10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVWLNKDDFIRDLKRISLCLLILYVVVVVGTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGDRSKESLVAFAMQHVRSTVTELSTGNFVNAIETAFAAGVGWLITFCSKGEDCLTSQTRLRLSGMLDGLVNVGWVDCDAQDSLCKSLDTTASTTAYFPPGATLNDREKSSVLFLNSLDAKEIYMEIIHNLPDFELLSANQLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSIHEYEGHHSAEQILEFIEDLRNPSVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKLYQYERAKKSIWEEQINSRDAKTIAALIYGKLETLQSQVKRNKDEL", "length": 793 }, "evidence": [ { "id": "F1N151", "url": "https://omabrowser.org/oma/group/F1N151/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" }, { "name": "protein-disulfide reductase activity", "id": "GO:0015035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015035", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" }, { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "id": "GO:0016671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016671", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" }, { "name": "protein folding in endoplasmic reticulum", "id": "GO:0034975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034975", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" }, { "name": "IRE1-mediated unfolded protein response", "id": "GO:0036498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036498", "evidence": [ { "database": "UniProtKB", "id": "F1N151", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21064", "name": "", "equation": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E936-1", "A0AAA9SI25-1", "F1N151-1" ], "evidence": [ { "id": "21064", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21064" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SI25", "gene_name": "", "activity": [ { "ec_number": "1.8.4.-", "activity": "", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] }, { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] } ] }, { "uniprot_ac": "F1N151", "gene_name": "DNAJC10", "activity": [ { "ec_number": "1.8.4.-", "activity": "", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] }, { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] } ] }, { "uniprot_ac": "Q5E936", "gene_name": "TXNDC12", "activity": [ { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 100, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" }, { "id": "PS51352", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51352" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 234, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.8.4.2", "ec_name": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "1.8.4.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.2" }, { "id": "1.8.4.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.8.4.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 530, "end_pos": 532 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1B8M2-1", "uniprot_ac": "E1B8M2", "uniprot_id": "E1B8M2_BOVIN", "mass": { "chemical_mass": 27586.0, "monoisotopic_mass": 27586.0 }, "refseq": { "ac": "XP_002696734", "name": "granzyme H", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696734" }, "gene_names": [ { "name": "LOC617313", "type": "recommended", "evidence": [ { "id": "E1B8M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M2" } ] }, { "name": "LOC617313", "type": "synonym", "evidence": [ { "id": "XP_002696734", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696734" } ] } ], "protein_names": [ { "name": "Granzyme H", "type": "synonym", "evidence": [ { "id": "E1B8M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M2/entry#names_and_taxonomy" } ] }, { "name": "granzyme H", "type": "synonym", "evidence": [ { "id": "XP_002696734", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696734" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8M2", "url": "https://www.uniprot.org/uniprotkb/E1B8M2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC617313", "url": "https://www.uniprot.org/uniprotkb/E1B8M2", "locus": {} } ], "crossref": [ { "id": "E1B8M2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8M2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010828", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010828", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617313", "url": "https://www.ncbi.nlm.nih.gov/gene/617313", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617313", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617313", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DQECEYV", "url": "https://omabrowser.org/oma/group/DQECEYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8M2", "url": "https://www.orthodb.org/?gene=E1B8M2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF70", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF70", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696734", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696734", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B8M2", "url": "https://www.uniprot.org/uniprotkb/E1B8M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8M2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8M2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLLLLLMAFLLPPGLGEPFLSEEIIGGHEAKPHSRPYMAFVQFLGEKSWKRCGGVLIQKDFVLTAAHCRGSSINVTLGAHNIKQQERTQQVIQVKRAIHHPDYNPKTFSNDIMLLQLERKAKQTSAVKPLSLPKAKAQVKPGEVCSLAGWGKVALGTPATTLQEVELTVQEDRVCESLNPRNYSRATQICVGDPRKVKTGFKGDSGGPLVCKKVVHGIFSYGKTNGTPPGVFTQVSHFLPWIKRTMKHL", "length": 250, "header": "tr|E1B8M2-1|E1B8M2_BOVIN Isoform 1 of Granzyme H OS=Bos taurus OX=9913 GN=LOC617313 PE=4 SV=2 CANONICAL=E1B8M2-1" }, "isoforms": [ { "isoform_ac": "E1B8M2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8M2/entry", "sequence": { "sequence": "MQLLLLLMAFLLPPGLGEPFLSEEIIGGHEAKPHSRPYMAFVQFLGEKSWKRCGGVLIQKDFVLTAAHCRGSSINVTLGAHNIKQQERTQQVIQVKRAIHHPDYNPKTFSNDIMLLQLERKAKQTSAVKPLSLPKAKAQVKPGEVCSLAGWGKVALGTPATTLQEVELTVQEDRVCESLNPRNYSRATQICVGDPRKVKTGFKGDSGGPLVCKKVVHGIFSYGKTNGTPPGVFTQVSHFLPWIKRTMKHL", "length": 250, "header": "tr|E1B8M2-1|E1B8M2_BOVIN Isoform 1 of Granzyme H OS=Bos taurus OX=9913 GN=LOC617313 PE=4 SV=2 CANONICAL=E1B8M2-1" }, "locus": { "chromosome": "21", "start_pos": 34814400, "end_pos": 34811520, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014364.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014364.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014364.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014364.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617313", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617313", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMKRL", "length": 246 }, "evidence": [ { "id": "E1B8M2", "url": "https://omabrowser.org/oma/group/E1B8M2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1B8M2", "url": "https://www.uniprot.org/uniprotkb/E1B8M2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B8M2", "url": "https://www.uniprot.org/uniprotkb/E1B8M2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M2" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 248, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 }, { "start_pos": 226, "end_pos": 228 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N0P0-1", "uniprot_ac": "F1N0P0", "uniprot_id": "F1N0P0_BOVIN", "mass": { "chemical_mass": 49231.0, "monoisotopic_mass": 49231.0 }, "refseq": {}, "gene_names": [ { "name": "TTYH1", "type": "recommended", "evidence": [ { "id": "F1N0P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ] } ], "protein_names": [ { "name": "Protein tweety homolog", "type": "recommended", "evidence": [ { "id": "F1N0P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0P0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM3#function" }, { "database": "UniProtKB", "id": "ARBA00044730", "url": "https://www.uniprot.org/uniprotkb/ARBA00044730#function" }, { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0#function" }, { "database": "UniProtKB", "id": "A0A3Q1MHC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHC3#function" } ] }, { "annotation": "Probable chloride channel.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM3#function" }, { "database": "UniProtKB", "id": "RU361114", "url": "https://www.uniprot.org/uniprotkb/RU361114#function" }, { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0#function" }, { "database": "UniProtKB", "id": "A0A3Q1MHC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHC3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTYH1", "url": "https://www.uniprot.org/uniprotkb/F1N0P0", "locus": { "chromosome": "18", "start_pos": 62875686, "end_pos": 62862327, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003470", "url": "https://www.ensembl.org/id/ENSBTAG00000003470" } ] } } ], "crossref": [ { "id": "F1N0P0", "url": "https://alphafold.ebi.ac.uk/entry/F1N0P0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003470", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003470", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767943", "url": "https://www.ncbi.nlm.nih.gov/gene/767943", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DFCSEPN", "url": "https://omabrowser.org/oma/group/DFCSEPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHC3", "url": "https://www.orthodb.org/?gene=A0A3Q1MHC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0P0", "url": "https://www.orthodb.org/?gene=F1N0P0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12424", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12424", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12424:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12424:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66336", "url": "https://www.rhea-db.org/rhea/66336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MHC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0P0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0P0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSAFAPQEREYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWNCIAALLVGCAGIGVGFYGNSETSDGVSQLSSALLHANHTLTAIDHLVLEMVERLDEAVRTELTTLEEVLTQRTELVAAARGARRQAETVAQQLQGLAFWRGVPLSPLQVAEDVSFVEEYRWLAYVLLLLLELLVCLFTLLGLARQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSSPDSYILNLTQEETGLGSDILNYYFLCNQAVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPVLSLEETLNVTEGNFHQLVALLHCRGLHKDYGSALRGLCEDTLEGLLFLLLFSLLSAGALATVLCSLPRAWALFPPSDDYEDTDDDDPFNPQESKRFVQWQSSI", "length": 450, "header": "tr|F1N0P0-1|F1N0P0_BOVIN Isoform 1 of Protein tweety homolog OS=Bos taurus OX=9913 GN=TTYH1 PE=3 SV=1 CANONICAL=F1N0P0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHC3/entry", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSAFAPQEREYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWNCIAALLVGCAGIGVGFYGNSETSDGVSQLSSALLHANHTLTAIDHLVLEMVERLDEAVRTELTTLEEVLTQRTELVAAARGARRQAETVAQQLQGLAFWRGVPLSPLQVAEDVSFVEEYRWLAYVLLLLLELLVCLFTLLGLARQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSSPDSYILNLTQEETGLGSDILNYYFLCNQAVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPVLSLEETLNVTEGNFHQLVALLHCRGLHKDYGSALRGLCEDTLEGLLFLLLFSLLSAGALATVLCSLPRAWALFPPRNPSASCSGSHQSEPFFQSRLEPGLHLCSFPGCRRRPH", "length": 460, "header": "tr|A0A3Q1MHC3-1|A0A3Q1MHC3_BOVIN Computationally mapped isoform of Protein tweety homolog OS=Bos taurus OX=9913 GN=TTYH1 PE=3 SV=1 CANONICAL=F1N0P0-1" }, "locus": { "chromosome": "18", "start_pos": 62875379, "end_pos": 62862402, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071175.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071175.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070050.1" } ] } }, { "isoform_ac": "A0AAA9SRM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM3/entry", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSAFAPQEREYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWNCIAALLVGCAGIGVGFYGNSETSDGVSQLSSALLHANHTLTAIDHLVLEMVERLDEAVRTELTTLEEVLTQRTELVAEDVSFVEEYRWLAYVLLLLLELLVCLFTLLGLARQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSSPDSYILNLTQEETGLGSDILNYYFLCNQAVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPVLSLEETLNVTEGNFHQLVALLHCRGLHKDYGSALRGLCEDTLEGLLFLLLFSLLSAGALATVLCSLPRAWALFPPSDDYEDTDDDDPFNPQESKRFVQWQSSI", "length": 417, "header": "tr|A0AAA9SRM3-1|F1N0P0_BOVIN Computationally mapped isoform of Protein tweety homolog OS=Bos taurus OX=9913 GN=TTYH1 PE=3 SV=1 CANONICAL=F1N0P0-1" }, "locus": { "chromosome": "18", "start_pos": 62875182, "end_pos": 62862402, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124291.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124291.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086611.1" } ] } }, { "isoform_ac": "F1N0P0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0P0/entry", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSAFAPQEREYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWNCIAALLVGCAGIGVGFYGNSETSDGVSQLSSALLHANHTLTAIDHLVLEMVERLDEAVRTELTTLEEVLTQRTELVAAARGARRQAETVAQQLQGLAFWRGVPLSPLQVAEDVSFVEEYRWLAYVLLLLLELLVCLFTLLGLARQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSSPDSYILNLTQEETGLGSDILNYYFLCNQAVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPVLSLEETLNVTEGNFHQLVALLHCRGLHKDYGSALRGLCEDTLEGLLFLLLFSLLSAGALATVLCSLPRAWALFPPSDDYEDTDDDDPFNPQESKRFVQWQSSI", "length": 450, "header": "tr|F1N0P0-1|F1N0P0_BOVIN Isoform 1 of Protein tweety homolog OS=Bos taurus OX=9913 GN=TTYH1 PE=3 SV=1 CANONICAL=F1N0P0-1" }, "locus": { "chromosome": "18", "start_pos": 62875182, "end_pos": 62862402, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004515.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004515.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004515.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004515.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5K1UQJ5-1", "protein_name": "Protein tweety homolog", "gene_name": "TTYH1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGCAGIGIGFYGNSETSDGVSQLSSALLHANHTLKAIDHLVLEMVERLGEAVRTELTTLEEVLTQRTELVAAARGARRQAEAVAQQLQGLAFWRGVPLSPVQVAEDVSYVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMGLLVLVLSWGSMGLEAATAVGLSDFCSSPDMYILNLTQEETGLGSDILNYYFLCNQEVSNPFQQRLTLSQRALANIHSQLQGLEREAVPQFPSAQKPLLSLEETLNTTEGNLHQLVALLHCRGLHKDYGTALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFSPQESKRFVQWQSSI", "length": 450 }, "evidence": [ { "id": "F1N0P0", "url": "https://omabrowser.org/oma/group/F1N0P0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P0C5X8-1", "protein_name": "Protein tweety homolog 1", "gene_name": "Ttyh1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGCAGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEEVLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYVLLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLEREASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGLLFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI", "length": 450 }, "evidence": [ { "id": "F1N0P0", "url": "https://omabrowser.org/oma/group/F1N0P0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D3A9-1", "protein_name": "Protein tweety homolog 1", "gene_name": "Ttyh1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPHGAKSPPPGGGCVTWSCIAALLVGCAGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDDVVLETVERLGEAVKTELTTLEEVLSVRMELVAATRGARRQAEAAAQYLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYVLLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDTYVLNLTQEETGLSSDILSYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLEREAIPQFSAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGLLFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI", "length": 450 }, "evidence": [ { "id": "F1N0P0", "url": "https://omabrowser.org/oma/group/F1N0P0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H313-1", "protein_name": "Protein tweety homolog 1", "gene_name": "TTYH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI", "length": 450 }, "evidence": [ { "id": "F1N0P0", "url": "https://omabrowser.org/oma/group/F1N0P0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "volume-sensitive chloride channel activity", "id": "GO:0072320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072320", "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "pmid": "" }, { "name": "intracellularly calcium-gated chloride channel activity", "id": "GO:0005229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005229", "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "pmid": "" }, { "name": "chloride channel activity", "id": "GO:0005254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005254", "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "pmid": "" }, { "name": "smooth endoplasmic reticulum membrane", "id": "GO:0030868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030868", "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "pmid": "" }, { "name": "chloride channel complex", "id": "GO:0034707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707", "evidence": [ { "database": "UniProtKB", "id": "F1N0P0", "url": "https://www.uniprot.org/uniprotkb/F1N0P0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29823", "name": "", "equation": "chloride(in) = chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN01-1", "Q5E9B7-1", "Q9XSA7-1", "P35071-1", "P35526-1" ], "evidence": [ { "id": "29823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29823" } ] }, { "id": "66336", "name": "", "equation": "L-glutamate(out) = L-glutamate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "66336", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66336" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] }, { "uniprot_ac": "Q5E9B7", "gene_name": "CLIC1", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] } ] }, { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 355, "end_pos": 357 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7ALE8-1", "uniprot_ac": "A0AAF7ALE8", "uniprot_id": "A0AAF7ALE8_BOVIN", "mass": { "chemical_mass": 35679.0, "monoisotopic_mass": 35679.0 }, "refseq": {}, "gene_names": [ { "name": "DRAM2", "type": "recommended", "evidence": [ { "id": "A0AAF7ALE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ] } ], "protein_names": [ { "name": "DNA damage regulated autophagy modulator 2", "type": "synonym", "evidence": [ { "id": "A0AAF7ALE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRAM2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8", "locus": { "chromosome": "3", "start_pos": 32300437, "end_pos": 32272397, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009888", "url": "https://www.ensembl.org/id/ENSBTAG00000009888" } ] } } ], "crossref": [ { "id": "A0AAF7ALE8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7ALE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21324", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21324", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21324:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21324:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10277", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10277", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ALE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKU8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKU8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGKSHGPRSLRGYSPWSHKESDTTERLHFHFHFVFTRSSSLPWGDLFEMWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV", "length": 315, "header": "tr|A0AAF7ALE8-1|A0AAF7ALE8_BOVIN Isoform 1 of DNA damage regulated autophagy modulator 2 OS=Bos taurus OX=9913 GN=DRAM2 PE=3 SV=1 CANONICAL=A0AAF7ALE8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK12/entry", "sequence": { "sequence": "MWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKPEKTKELLRKEAYFS", "length": 247, "header": "tr|A0AAA9SK12-1|A0AAF7ALE8_BOVIN Computationally mapped isoform of DNA damage regulated autophagy modulator 2 OS=Bos taurus OX=9913 GN=DRAM2 PE=3 SV=1 CANONICAL=A0AAF7ALE8-1" }, "locus": { "chromosome": "3", "start_pos": 32299266, "end_pos": 32281499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124012.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124012.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084194.1" } ] } }, { "isoform_ac": "A0AAF7ALE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8/entry", "sequence": { "sequence": "MPGKSHGPRSLRGYSPWSHKESDTTERLHFHFHFVFTRSSSLPWGDLFEMWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV", "length": 315, "header": "tr|A0AAF7ALE8-1|A0AAF7ALE8_BOVIN Isoform 1 of DNA damage regulated autophagy modulator 2 OS=Bos taurus OX=9913 GN=DRAM2 PE=3 SV=1 CANONICAL=A0AAF7ALE8-1" }, "locus": { "chromosome": "3", "start_pos": 32299544, "end_pos": 32273112, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070934.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070934.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071255.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071255.2" } ] } }, { "isoform_ac": "A0ABI0NKU8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKU8/entry", "sequence": { "sequence": "MLVWGNVKYRRSFMTLSTVACQAPLSMAFSRQEYWRGCHPFLQRIFLTQGSTSLISLALAGVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV", "length": 260, "header": "tr|A0ABI0NKU8-1|A0ABI0NKU8_BOVIN Computationally mapped isoform of DNA damage regulated autophagy modulator 2 OS=Bos taurus OX=9913 GN=DRAM2 PE=3 SV=1 CANONICAL=A0AAF7ALE8-1" }, "locus": { "chromosome": "3", "start_pos": 32299544, "end_pos": 32285678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148177.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148177.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105447.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105447.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" }, { "name": "photoreceptor cell maintenance", "id": "GO:0045494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045494", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7ALE8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7ALE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ALE8" }, { "id": "PF10277", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10277" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CWH43-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 282, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 231, "end_pos": 233 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0AAF7AHP7-1", "uniprot_ac": "A0AAF7AHP7", "uniprot_id": "A0AAF7AHP7_BOVIN", "mass": { "chemical_mass": 19863.0, "monoisotopic_mass": 19863.0 }, "refseq": {}, "gene_names": [ { "name": "EIF5A", "type": "recommended", "evidence": [ { "id": "A0AAF7AHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 5A", "type": "synonym", "evidence": [ { "id": "A0AAF7AHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF5A", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7", "locus": { "chromosome": "19", "start_pos": 27020476, "end_pos": 27015093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002018", "url": "https://www.ensembl.org/id/ENSBTAG00000002018" } ] } } ], "crossref": [ { "id": "A0AAF7AHP7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAF7AHP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04468", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04468", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11673", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11673", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01287", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01287", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAF7AHP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AHP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGTGGMGFATRGPPHSTSFLKRLESPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK", "length": 183, "header": "tr|A0AAF7AHP7-1|A0AAF7AHP7_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5A OS=Bos taurus OX=9913 GN=EIF5A PE=3 SV=1 CANONICAL=A0AAF7AHP7-1" }, "isoforms": [ { "isoform_ac": "A0AAF7AHP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7/entry", "sequence": { "sequence": "MSGTGGMGFATRGPPHSTSFLKRLESPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK", "length": 183, "header": "tr|A0AAF7AHP7-1|A0AAF7AHP7_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5A OS=Bos taurus OX=9913 GN=EIF5A PE=3 SV=1 CANONICAL=A0AAF7AHP7-1" }, "locus": { "chromosome": "19", "start_pos": 27019666, "end_pos": 27015093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084447.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084447.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069104.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069104.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AHP7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAF7AHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHP7" }, { "id": "SM01376", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01376" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Translation initiation factor 5A C-terminal", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 179, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7G3-1", "uniprot_ac": "F1N7G3", "uniprot_id": "F1N7G3_BOVIN", "mass": { "chemical_mass": 38886.0, "monoisotopic_mass": 38886.0 }, "refseq": {}, "gene_names": [ { "name": "WNT9B", "type": "recommended", "evidence": [ { "id": "F1N7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ] } ], "protein_names": [ { "name": "Protein Wnt", "type": "recommended", "evidence": [ { "id": "F1N7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ligand for members of the frizzled family of seven transmembrane receptors.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1A0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A0#function" }, { "database": "UniProtKB", "id": "RU003500", "url": "https://www.uniprot.org/uniprotkb/RU003500#function" }, { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WNT9B", "url": "https://www.uniprot.org/uniprotkb/F1N7G3", "locus": { "chromosome": "19", "start_pos": 45335094, "end_pos": 45356585, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002664", "url": "https://www.ensembl.org/id/ENSBTAG00000002664" } ] } } ], "crossref": [ { "id": "F1N7G3", "url": "https://alphafold.ebi.ac.uk/entry/F1N7G3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002664", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002664", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19354", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19354", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1A0", "url": "https://www.orthodb.org/?gene=A0A3Q1M1A0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7G3", "url": "https://www.orthodb.org/?gene=F1N7G3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027:SF84", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027:SF84", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238698", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M1A0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1A0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7G3-1", "url": "https://www.uniprot.org/uniprotkb/F1N7G3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPPPALALAALCLLALPAAAAAAYFGLTGREVLTPFPGLGTAAPAQGGAHLKQCDLLKLSRRQKQLCRREPGLAETLQDAAHLSLLECQFQFRHERWNCSLEGRTGLLKRGFKETAFLYAVSAAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLNNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRDTGQVLKLRYDSAVKVSSASNEALGRLELWAPARPGSPSKGPAPRPGDLVYMEDSPSFCRPSKYSPGTGGRVCSREASCSSLCCGRGYDTQSRLTAFSCHCQVQWCCYVECQQCVREELVYTCKH", "length": 357, "header": "tr|F1N7G3-1|F1N7G3_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT9B PE=3 SV=4 CANONICAL=F1N7G3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1A0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A0/entry", "sequence": { "sequence": "MRPPPALALAALCLLALPAAAAAAYFGSFGDMLHTGLAAPDGFGIYSLTGREVLTPFPGLGTAAPAQGGAHLKQCDLLKLSRRQKQLCRREPGLAETLQDAAHLSLLECQFQFRHERWNCSLEGRTGLLKRGFKETAFLYAVSAAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLNNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRDTGQVLKLRYDSAVKVSSASNEALGRLELWAPARPGSPSKGPAPRPGDLVYMEDSPSFCRPSKYSPGTGGRVCSREASCSSLCCGRGYDTQSRLTAFSCHCQVQWCCYVECQQCVREELVYTCKH", "length": 377, "header": "tr|A0A3Q1M1A0-1|F1N7G3_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT9B PE=3 SV=2 CANONICAL=F1N7G3-1" }, "locus": { "chromosome": "19", "start_pos": 45356357, "end_pos": 45336098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086580.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086580.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061815.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061815.2" } ] } }, { "isoform_ac": "F1N7G3-1", "url": "https://www.uniprot.org/uniprotkb/F1N7G3/entry", "sequence": { "sequence": "MRPPPALALAALCLLALPAAAAAAYFGLTGREVLTPFPGLGTAAPAQGGAHLKQCDLLKLSRRQKQLCRREPGLAETLQDAAHLSLLECQFQFRHERWNCSLEGRTGLLKRGFKETAFLYAVSAAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLNNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRDTGQVLKLRYDSAVKVSSASNEALGRLELWAPARPGSPSKGPAPRPGDLVYMEDSPSFCRPSKYSPGTGGRVCSREASCSSLCCGRGYDTQSRLTAFSCHCQVQWCCYVECQQCVREELVYTCKH", "length": 357, "header": "tr|F1N7G3-1|F1N7G3_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT9B PE=3 SV=4 CANONICAL=F1N7G3-1" }, "locus": { "chromosome": "19", "start_pos": 45356357, "end_pos": 45336098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003449.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003449.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003449.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003449.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3238698", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238698", "resource": "Reactome", "description": "WNT ligand biogenesis and trafficking" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of stem cell population maintenance", "id": "GO:1902455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902455", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "non-canonical Wnt signaling pathway", "id": "GO:0035567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035567", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "cell fate commitment", "id": "GO:0045165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "midbrain dopaminergic neuron differentiation", "id": "GO:1904948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904948", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "frizzled binding", "id": "GO:0005109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005109", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "co-receptor binding", "id": "GO:0039706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039706", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N7G3", "url": "https://www.uniprot.org/uniprotkb/F1N7G3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Y3-1", "uniprot_ac": "F1N6Y3", "uniprot_id": "F1N6Y3_BOVIN", "mass": { "chemical_mass": 65832.0, "monoisotopic_mass": 65832.0 }, "refseq": { "ac": "XP_005223106", "name": "parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223106" }, "gene_names": [ { "name": "PTH1R", "type": "recommended", "evidence": [ { "id": "F1N6Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ] }, { "name": "PTH1R", "type": "synonym", "evidence": [ { "id": "XP_005223106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223106" } ] }, { "name": "PTHR1", "type": "synonym", "evidence": [ { "id": "XP_005223106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223106" } ] } ], "protein_names": [ { "name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "type": "recommended", "evidence": [ { "id": "F1N6Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3/entry#names_and_taxonomy" } ] }, { "name": "PTH/PTHrP type I receptor", "type": "synonym", "evidence": [ { "id": "F1N6Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3/entry#names_and_taxonomy" } ] }, { "name": "Parathyroid hormone 1 receptor", "type": "synonym", "evidence": [ { "id": "F1N6Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3/entry#names_and_taxonomy" } ] }, { "name": "parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005223106", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223106" } ] } ], "function": [ { "annotation": "G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MQC7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQC7#function" }, { "database": "UniProtKB", "id": "ARBA00093433", "url": "https://www.uniprot.org/uniprotkb/ARBA00093433#function" }, { "database": "UniProtKB", "id": "A0A3Q1LI90", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI90#function" }, { "database": "UniProtKB", "id": "A0A3Q1N0Y5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y5#function" }, { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTH1R", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3", "locus": { "chromosome": "22", "start_pos": 52598232, "end_pos": 52623665, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016948", "url": "https://www.ensembl.org/id/ENSBTAG00000016948" } ] } } ], "crossref": [ { "id": "F1N6Y3", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Y3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016948", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016948", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15984", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15984", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507783", "url": "https://www.ncbi.nlm.nih.gov/gene/507783", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LICWPEG", "url": "https://omabrowser.org/oma/group/LICWPEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQC7", "url": "https://www.orthodb.org/?gene=A0A3Q1MQC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N0Y5", "url": "https://www.orthodb.org/?gene=A0A3Q1N0Y5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N6Y3", "url": "https://www.orthodb.org/?gene=F1N6Y3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005223106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LI90", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LI90-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQC7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0Y5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y3-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPADIMESDKGWASASTSGKPKKEKPSGKLHPESEEDKEVPTGSRPRGRPCLPEWDHILCWPLGAPGEVVAMPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGTALDEAERLTEEELRAIAQAPPPPAAAAGYVGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAIFVAVWVGVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRTGLGLPLSPRLLPAATTNGHPPLPGHTKSGSPALQATPPAVAAPKEDGFLNGSCSGLDEEACAPERPPVLLQEEWETVM", "length": 589, "header": "tr|F1N6Y3-1|F1N6Y3_BOVIN Isoform 1 of Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Bos taurus OX=9913 GN=PTH1R PE=3 SV=2 CANONICAL=F1N6Y3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LI90-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI90/entry", "sequence": { "sequence": "MKKLRLRQQESRRVQDYTTGPAAAAAPRDGALGGGDGGRPDRARPGALALLPSAQLRIRAADIMESDKGWASASTSGKPKKEKPSGKLHPESEEDKEVPTGSRPRGRPCLPEWDHILCWPLGAPGEVVAMPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGTALDEAERLTEEELRAIAQAPPPPAAAAGYVGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAIFVAVWVGVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRTGLGLPLSPRLLPAATTNGHPPLPGHTKSGSPALQATPPAVAAPKEDGFLNGSCSGLDEEACAPERPPVLLQEEWETVM", "length": 590, "header": "tr|A0A3Q1LI90-1|A0A3Q1LI90_BOVIN Computationally mapped isoform of Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Bos taurus OX=9913 GN=PTH1R PE=3 SV=1 CANONICAL=F1N6Y3-1" }, "locus": { "chromosome": "22", "start_pos": 52621102, "end_pos": 52598378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070865.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070865.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058682.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058682.2" } ] } }, { "isoform_ac": "A0A3Q1MQC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQC7/entry", "sequence": { "sequence": "MGAARIAPGLALLLCCPVLSSAYALGPQQTARSGEHPSWDIPSLSHAPLGNRLDSDYQKLPSMGLLSDKWGTAPLPSPFFPLVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPADIMESDKGWASASTSGKPKKEKPSGKLHPESEEDKEVPTGSRPRGRPCLPEWDHILCWPLGAPGEVVAMPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGTALDEAERLTEEELRAIAQAPPPPAAAAGYVGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAIFVAVWVGVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRTGLGLPLSPRLLPAATTNGHPPLPGHTKSGSPALQATPPAVAAPKEDGFLNGSCSGLDEEACAPERPPVLLQEEWETVM", "length": 646, "header": "tr|A0A3Q1MQC7-1|F1N6Y3_BOVIN Computationally mapped isoform of Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Bos taurus OX=9913 GN=PTH1R PE=3 SV=1 CANONICAL=F1N6Y3-1" }, "locus": { "chromosome": "22", "start_pos": 52618667, "end_pos": 52598378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068142.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068142.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073806.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073806.1" } ] } }, { "isoform_ac": "A0A3Q1N0Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y5/entry", "sequence": { "sequence": "MARRGPRRRARTDIMESDKGWASASTSGKPKKEKPSGKLHPESEEDKEVPTGSRPRGRPCLPEWDHILCWPLGAPGEVVAMPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGTALDEAERLTEEELRAIAQAPPPPAAAAGYVGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAIFVAVWVGVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRTGLGLPLSPRLLPAATTNGHPPLPGHTKSGSPALQATPPAVAAPKEDGFLNGSCSGLDEEACAPERPPVLLQEEWETVM", "length": 541, "header": "tr|A0A3Q1N0Y5-1|F1N6Y3_BOVIN Computationally mapped isoform of Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Bos taurus OX=9913 GN=PTH1R PE=3 SV=2 CANONICAL=F1N6Y3-1" }, "locus": { "chromosome": "22", "start_pos": 52619770, "end_pos": 52598378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070571.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070571.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062510.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062510.2" } ] } }, { "isoform_ac": "F1N6Y3-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3/entry", "sequence": { "sequence": "MGAARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPADIMESDKGWASASTSGKPKKEKPSGKLHPESEEDKEVPTGSRPRGRPCLPEWDHILCWPLGAPGEVVAMPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGTALDEAERLTEEELRAIAQAPPPPAAAAGYVGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAIFVAVWVGVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRTGLGLPLSPRLLPAATTNGHPPLPGHTKSGSPALQATPPAVAAPKEDGFLNGSCSGLDEEACAPERPPVLLQEEWETVM", "length": 589, "header": "tr|F1N6Y3-1|F1N6Y3_BOVIN Isoform 1 of Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Bos taurus OX=9913 GN=PTH1R PE=3 SV=2 CANONICAL=F1N6Y3-1" }, "locus": { "chromosome": "22", "start_pos": 52618667, "end_pos": 52598378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022555.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022555.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022555.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022555.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-373080", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "resource": "Reactome", "description": "Class B/2 (Secretin family receptors)" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "P25961-1", "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "Pth1r", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM", "length": 591 }, "evidence": [ { "id": "F1N6Y3", "url": "https://omabrowser.org/oma/group/F1N6Y3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P41593-1", "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "Pth1r", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKAPGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLLPATTNGHSQLPGHAKPGAPAIENETIPVTMTVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM", "length": 591 }, "evidence": [ { "id": "F1N6Y3", "url": "https://omabrowser.org/oma/group/F1N6Y3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q03431-1", "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "PTH1R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM", "length": 593 }, "evidence": [ { "id": "F1N6Y3", "url": "https://omabrowser.org/oma/group/F1N6Y3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" }, { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" }, { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" }, { "name": "parathyroid hormone receptor activity", "id": "GO:0004991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004991", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y3", "url": "https://www.uniprot.org/uniprotkb/F1N6Y3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 561, "end_pos": 563, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Y3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 589, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Y3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Y3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 561, "end_pos": 563 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7B5-1", "uniprot_ac": "F1N7B5", "uniprot_id": "F1N7B5_BOVIN", "mass": { "chemical_mass": 90955.0, "monoisotopic_mass": 90955.0 }, "refseq": { "ac": "XP_002693012", "name": "cullin-5 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693012" }, "gene_names": [ { "name": "CUL5", "type": "recommended", "evidence": [ { "id": "F1N7B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ] }, { "name": "CUL5", "type": "synonym", "evidence": [ { "id": "XP_002693012", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693012" } ] } ], "protein_names": [ { "name": "Cullin-5", "type": "recommended", "evidence": [ { "id": "F1N7B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B5/entry#names_and_taxonomy" } ] }, { "name": "cullin-5 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002693012", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693012" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CUL5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5", "locus": { "chromosome": "15", "start_pos": 17719342, "end_pos": 17591380, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012882", "url": "https://www.ensembl.org/id/ENSBTAG00000012882" } ] } } ], "crossref": [ { "id": "F1N7B5", "url": "https://alphafold.ebi.ac.uk/entry/F1N7B5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012882", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012882", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510331", "url": "https://www.ncbi.nlm.nih.gov/gene/510331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MXH0", "url": "https://www.orthodb.org/?gene=A0A3Q1MXH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7B5", "url": "https://www.orthodb.org/?gene=F1N7B5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00888", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00888", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8863795", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9705462", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9705462", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002693012", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693012", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7B5-1", "url": "https://www.uniprot.org/uniprotkb/F1N7B5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA", "length": 780, "header": "tr|F1N7B5-1|F1N7B5_BOVIN Isoform 1 of Cullin-5 OS=Bos taurus OX=9913 GN=CUL5 PE=3 SV=4 CANONICAL=F1N7B5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXH0/entry", "sequence": { "sequence": "MLPLPISDLKCLSYPWKCKGDYLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA", "length": 796, "header": "tr|A0A3Q1MXH0-1|F1N7B5_BOVIN Computationally mapped isoform of Cullin-5 OS=Bos taurus OX=9913 GN=CUL5 PE=3 SV=2 CANONICAL=F1N7B5-1" }, "locus": { "chromosome": "15", "start_pos": 17718338, "end_pos": 17591682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068692.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068692.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060422.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060422.2" } ] } }, { "isoform_ac": "A0AAA9SPJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ7/entry", "sequence": { "sequence": "MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGISLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA", "length": 726, "header": "tr|A0AAA9SPJ7-1|F1N7B5_BOVIN Computationally mapped isoform of Cullin-5 OS=Bos taurus OX=9913 GN=CUL5 PE=3 SV=1 CANONICAL=F1N7B5-1" }, "locus": { "chromosome": "15", "start_pos": 17718338, "end_pos": 17591990, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120538.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120538.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088218.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088218.1" } ] } }, { "isoform_ac": "F1N7B5-1", "url": "https://www.uniprot.org/uniprotkb/F1N7B5/entry", "sequence": { "sequence": "MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA", "length": 780, "header": "tr|F1N7B5-1|F1N7B5_BOVIN Isoform 1 of Cullin-5 OS=Bos taurus OX=9913 GN=CUL5 PE=3 SV=4 CANONICAL=F1N7B5-1" }, "locus": { "chromosome": "15", "start_pos": 17718338, "end_pos": 17591990, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061240.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061240.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053628.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053628.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510331", "resource": "KEGG Pathway" }, { "id": "R-BTA-8863795", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "resource": "Reactome", "description": "Downregulation of ERBB2 signaling" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9705462", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9705462", "resource": "Reactome", "description": "Inactivation of CSF3 (G-CSF) signaling" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "Cul5-RING ubiquitin ligase complex", "id": "GO:0031466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031466", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "cullin-RING ubiquitin ligase complex", "id": "GO:0031461", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031461", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "negative regulation of focal adhesion assembly", "id": "GO:0051895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051895", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "negative regulation of focal adhesion disassembly", "id": "GO:0120184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120184", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" }, { "name": "ubiquitin ligase complex scaffold activity", "id": "GO:0160072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160072", "evidence": [ { "database": "UniProtKB", "id": "F1N7B5", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7B5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 780, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7B5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7B5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B5" }, { "id": "PS50069", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50069" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cullin family profile", "eco_id": "ECO_0000259", "start_pos": 403, "end_pos": 638, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 288, "end_pos": 290 }, { "start_pos": 565, "end_pos": 567 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QM28-1", "uniprot_ac": "F6QM28", "uniprot_id": "F6QM28_BOVIN", "mass": { "chemical_mass": 58539.0, "monoisotopic_mass": 58539.0 }, "refseq": {}, "gene_names": [ { "name": "NFIA", "type": "recommended", "evidence": [ { "id": "F6QM28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ] } ], "protein_names": [ { "name": "Nuclear factor 1", "type": "recommended", "evidence": [ { "id": "F6QM28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QM28/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MY20", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY20#function" }, { "database": "UniProtKB", "id": "RU000690", "url": "https://www.uniprot.org/uniprotkb/RU000690#function" }, { "database": "UniProtKB", "id": "A0A3Q1NFV6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFV6#function" }, { "database": "UniProtKB", "id": "A0AAA9S3U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U3#function" }, { "database": "UniProtKB", "id": "A0AAA9T9F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F8#function" }, { "database": "UniProtKB", "id": "A0AAA9U162", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U162#function" }, { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28#function" }, { "database": "UniProtKB", "id": "A0A3Q1LM06", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM06#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3A7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFIA", "url": "https://www.uniprot.org/uniprotkb/F6QM28", "locus": { "chromosome": "3", "start_pos": 84203465, "end_pos": 84816448, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000074", "url": "https://www.ensembl.org/id/ENSBTAG00000000074" } ] } } ], "crossref": [ { "id": "F6QM28", "url": "https://alphafold.ebi.ac.uk/entry/F6QM28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615371", "url": "https://www.ncbi.nlm.nih.gov/gene/615371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000647", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000647", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003619", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003619", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LM06", "url": "https://www.orthodb.org/?gene=A0A3Q1LM06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3A7", "url": "https://www.orthodb.org/?gene=A0A3Q1M3A7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MY20", "url": "https://www.orthodb.org/?gene=A0A3Q1MY20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NFV6", "url": "https://www.orthodb.org/?gene=A0A3Q1NFV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11492", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11492", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11492:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11492:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00859", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00859", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10524", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10524", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LM06", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM06-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3A7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3A7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MY20", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MY20-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFV6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFV6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U162", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U162", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U162-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U162-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QM28-1", "url": "https://www.uniprot.org/uniprotkb/F6QM28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLADSVMAGKASDGSIKWQLCYDISARTWWMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG", "length": 532, "header": "tr|F6QM28-1|F6QM28_BOVIN Isoform 1 of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=1 CANONICAL=F6QM28-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LM06-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM06/entry", "sequence": { "sequence": "MSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPILVPGIKVAASHHPPDRPPDPFSTL", "length": 451, "header": "tr|A0A3Q1LM06-1|A0A3Q1LM06_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=2 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84591767, "end_pos": 84204469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066700.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066700.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060882.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060882.2" } ] } }, { "isoform_ac": "A0A3Q1M3A7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A7/entry", "sequence": { "sequence": "MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAAGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG", "length": 487, "header": "tr|A0A3Q1M3A7-1|A0A3Q1M3A7_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=2 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84597324, "end_pos": 84204528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075773.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075773.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067974.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067974.2" } ] } }, { "isoform_ac": "A0A3Q1MY20-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY20/entry", "sequence": { "sequence": "MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG", "length": 504, "header": "tr|A0A3Q1MY20-1|F6QM28_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=2 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84597324, "end_pos": 84204528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068271.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068271.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060815.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060815.2" } ] } }, { "isoform_ac": "A0A3Q1NFV6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFV6/entry", "sequence": { "sequence": "MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG", "length": 466, "header": "tr|A0A3Q1NFV6-1|F6QM28_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=2 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84597324, "end_pos": 84204528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068642.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068642.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070602.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070602.2" } ] } }, { "isoform_ac": "A0AAA9S3U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U3/entry", "sequence": { "sequence": "VDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPILVPGIKVAASHHPPDRPPDPFSTL", "length": 490, "header": "tr|A0AAA9S3U3-1|F6QM28_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=1 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84602531, "end_pos": 84204469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088034.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088034.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079773.1" } ] } }, { "isoform_ac": "A0AAA9T9F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F8/entry", "sequence": { "sequence": "MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPILVPGIKVAASHHPPDRPPDPFSTL", "length": 498, "header": "tr|A0AAA9T9F8-1|F6QM28_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=1 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84597324, "end_pos": 84204469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092154.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092154.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093264.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093264.1" } ] } }, { "isoform_ac": "A0AAA9U162-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U162/entry", "sequence": { "sequence": "MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQRMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPILVPGIKVAASHHPPDRPPDPFSTL", "length": 416, "header": "tr|A0AAA9U162-1|F6QM28_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=1 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84597324, "end_pos": 84204469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123584.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123584.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103484.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103484.1" } ] } }, { "isoform_ac": "F6QM28-1", "url": "https://www.uniprot.org/uniprotkb/F6QM28/entry", "sequence": { "sequence": "MKLADSVMAGKASDGSIKWQLCYDISARTWWMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPSPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYLG", "length": 532, "header": "tr|F6QM28-1|F6QM28_BOVIN Isoform 1 of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIA PE=3 SV=1 CANONICAL=F6QM28-1" }, "locus": { "chromosome": "3", "start_pos": 84816448, "end_pos": 84204528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033431.4", "url": "https://www.ensembl.org/id/ENSBTAT00000033431.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033344.3", "url": "https://www.ensembl.org/id/ENSBTAP00000033344.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 387, "start_aa": "Thr", "end_pos": 387, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr387", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 500, "start_aa": "Thr", "end_pos": 500, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr500", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "cartilage development", "id": "GO:0051216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" }, { "name": "limb morphogenesis", "id": "GO:0035108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035108", "evidence": [ { "database": "UniProtKB", "id": "F6QM28", "url": "https://www.uniprot.org/uniprotkb/F6QM28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QM28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QM28" }, { "id": "PS51080", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTF/NF-I", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 217, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 387, 500 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 }, { "start_pos": 443, "end_pos": 445 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7H7-1", "uniprot_ac": "F1N7H7", "uniprot_id": "F1N7H7_BOVIN", "mass": { "chemical_mass": 71480.0, "monoisotopic_mass": 71480.0 }, "refseq": {}, "gene_names": [ { "name": "DYNC1I2", "type": "recommended", "evidence": [ { "id": "F1N7H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ] } ], "protein_names": [ { "name": "Cytoplasmic dynein 1 intermediate chain 2", "type": "recommended", "evidence": [ { "id": "F1N7H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7H7/entry#names_and_taxonomy" } ] }, { "name": "Cytoplasmic dynein intermediate chain 2", "type": "synonym", "evidence": [ { "id": "F1N7H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7H7/entry#names_and_taxonomy" } ] }, { "name": "Dynein intermediate chain 2, cytosolic", "type": "synonym", "evidence": [ { "id": "F1N7H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7H7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.", "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7#function" }, { "database": "UniProtKB", "id": "ARBA00045429", "url": "https://www.uniprot.org/uniprotkb/ARBA00045429#function" }, { "database": "UniProtKB", "id": "A0A3Q1MY28", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY28#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DYNC1I2", "url": "https://www.uniprot.org/uniprotkb/F1N7H7", "locus": { "chromosome": "2", "start_pos": 24765631, "end_pos": 24837040, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002646", "url": "https://www.ensembl.org/id/ENSBTAG00000002646" } ] } } ], "crossref": [ { "id": "F1N7H7", "url": "https://alphafold.ebi.ac.uk/entry/F1N7H7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002646", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002646", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12442:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12442:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11540", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11540", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MY28", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MY28-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7H7-1", "url": "https://www.uniprot.org/uniprotkb/F1N7H7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREAEALLQSMGLTAESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDPSVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEEDDVVTPKPPIEPEEEKTLKKDEESDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHSAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA", "length": 638, "header": "tr|F1N7H7-1|F1N7H7_BOVIN Isoform 1 of Cytoplasmic dynein 1 intermediate chain 2 OS=Bos taurus OX=9913 GN=DYNC1I2 PE=3 SV=4 CANONICAL=F1N7H7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MY28-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY28/entry", "sequence": { "sequence": "MFNRGLDTHYYSTECWLHEVANMSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREAEALLQSMGLTAESPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEEDDVVTPKPPIEPEEEKTLKKDEESDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHSAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA", "length": 634, "header": "tr|A0A3Q1MY28-1|F1N7H7_BOVIN Computationally mapped isoform of Cytoplasmic dynein 1 intermediate chain 2 OS=Bos taurus OX=9913 GN=DYNC1I2 PE=3 SV=2 CANONICAL=F1N7H7-1" }, "locus": { "chromosome": "2", "start_pos": 24836936, "end_pos": 24766153, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084203.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084203.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060831.2" } ] } }, { "isoform_ac": "F1N7H7-1", "url": "https://www.uniprot.org/uniprotkb/F1N7H7/entry", "sequence": { "sequence": "MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREAEALLQSMGLTAESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDPSVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEEDDVVTPKPPIEPEEEKTLKKDEESDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHSAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA", "length": 638, "header": "tr|F1N7H7-1|F1N7H7_BOVIN Isoform 1 of Cytoplasmic dynein 1 intermediate chain 2 OS=Bos taurus OX=9913 GN=DYNC1I2 PE=3 SV=4 CANONICAL=F1N7H7-1" }, "locus": { "chromosome": "2", "start_pos": 24817941, "end_pos": 24766153, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003429.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003429.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003429.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003429.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ], "pmid": "" }, { "name": "cytoplasmic dynein complex", "id": "GO:0005868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005868", "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "F1N7H7", "url": "https://www.uniprot.org/uniprotkb/F1N7H7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7H7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 638, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7H7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7H7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 362, "end_pos": 364 }, { "start_pos": 556, "end_pos": 558 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QLA1-1", "uniprot_ac": "F6QLA1", "uniprot_id": "F6QLA1_BOVIN", "mass": { "chemical_mass": 45934.0, "monoisotopic_mass": 45934.0 }, "refseq": {}, "gene_names": [ { "name": "PTGDR2", "type": "recommended", "evidence": [ { "id": "F6QLA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ] } ], "protein_names": [ { "name": "Chemerin-like receptor 1", "type": "recommended", "evidence": [ { "id": "F6QLA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QLA1/entry#names_and_taxonomy" } ] }, { "name": "Chemokine-like receptor 1", "type": "synonym", "evidence": [ { "id": "F6QLA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QLA1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N2W9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2W9#function" }, { "database": "UniProtKB", "id": "ARBA00057460", "url": "https://www.uniprot.org/uniprotkb/ARBA00057460#function" }, { "database": "UniProtKB", "id": "A0AAA9SJN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN5#function" }, { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTGDR2", "url": "https://www.uniprot.org/uniprotkb/F6QLA1", "locus": { "chromosome": "29", "start_pos": 37177949, "end_pos": 37187618, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039652", "url": "https://www.ensembl.org/id/ENSBTAG00000039652" } ] } } ], "crossref": [ { "id": "F6QLA1", "url": "https://alphafold.ebi.ac.uk/entry/F6QLA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039652", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039652", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "337885", "url": "https://www.ncbi.nlm.nih.gov/gene/337885", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:337885", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337885", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPDLCRK", "url": "https://omabrowser.org/oma/group/CPDLCRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N2W9", "url": "https://www.orthodb.org/?gene=A0A3Q1N2W9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QLA1", "url": "https://www.orthodb.org/?gene=F6QLA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24225", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24225", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24225:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24225:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-391908", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391908", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N2W9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2W9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2W9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QLA1-1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRHREPTMLANVTTKPLCPLLEQMSRLQSHSNSSIRYMDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLATASLPFFTYFLAVGHSWKLGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVSAAHKVCLALWVLAVINTVPYFVFRDTIPRLDGRIMCYYNVLLLSPGPDRNATCDSRQTALAVSKFLLAFAVPLAIIASSHLAVSAQLRHRGRRRSSRFVRLVAAVVAAFALCWGPYHVFSVMEARAHANPSLRPLVWRGLPFVTSLAFINSVINPLLYVLTCPDVLRKLRRSLRSVLESVLVDDSDLAAGGSNRRRRRASSTNASASSISESSGHRLHALWPARLLDWLRGDPAAPPQRDRTPSQDERGPLNRALSTTSG", "length": 414, "header": "tr|F6QLA1-1|F6QLA1_BOVIN Isoform 1 of Chemerin-like receptor 1 OS=Bos taurus OX=9913 GN=PTGDR2 PE=3 SV=3 CANONICAL=F6QLA1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N2W9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2W9/entry", "sequence": { "sequence": "MPEPTMLANVTTKPLCPLLEQMSRLQSHSNSSIRYMDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLATASLPFFTYFLAVGHSWKLGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVSAAHKVCLALWVLAVINTVPYFVFRDTIPRLDGRIMCYYNVLLLSPGPDRNATCDSRQTALAVSKFLLAFAVPLAIIASSHLAVSAQLRHRGRRRSSRFVRLVAAVVAAFALCWGPYHVFSVMEARAHANPSLRPLVWRGLPFVTSLAFINSVINPLLYVLTCPDVLRKLRRSLRSVLESVLVDDSDLAAGGSNRRRRRASSTNASASSISESSGHRLHALWPARLLDWLRGDPAAPPQRDRTPSQDERGPLNRALSTTSG", "length": 411, "header": "tr|A0A3Q1N2W9-1|F6QLA1_BOVIN Computationally mapped isoform of Chemerin-like receptor 1 OS=Bos taurus OX=9913 GN=PTGDR2 PE=3 SV=2 CANONICAL=F6QLA1-1" }, "locus": { "chromosome": "29", "start_pos": 37183880, "end_pos": 37180318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066986.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066986.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063682.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063682.2" } ] } }, { "isoform_ac": "A0AAA9SJN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN5/entry", "sequence": { "sequence": "MLANVTTKPLCPLLEQMSRLQSHSNSSIRYMDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLATASLPFFTYFLAVGHSWKLGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVSAAHKVCLALWVLAVINTVPYFVFRDTIPRLDGRIMCYYNVLLLSPGPDRNATCDSRQTALAVSKFLLAFAVPLAIIASSHLAVSAQLRHRGRRRSSRFVRLVAAVVAAFALCWGPYHVFSVMEARAHANPSLRPLVWRGLPFVTSLAFINSVINPLLYVLTCPDVLRKLRRSLRSVLESVLVDDSDLAAGGSNRRRRRASSTNASASSISESSGHRLHALWPARLLDWLRGDPAAPPQRDRTPSQDERGPLNRALSTTSG", "length": 406, "header": "tr|A0AAA9SJN5-1|F6QLA1_BOVIN Computationally mapped isoform of Chemerin-like receptor 1 OS=Bos taurus OX=9913 GN=PTGDR2 PE=3 SV=1 CANONICAL=F6QLA1-1" }, "locus": { "chromosome": "29", "start_pos": 37181535, "end_pos": 37180318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124868.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124868.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085546.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085546.1" } ] } }, { "isoform_ac": "F6QLA1-1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1/entry", "sequence": { "sequence": "MQRHREPTMLANVTTKPLCPLLEQMSRLQSHSNSSIRYMDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLATASLPFFTYFLAVGHSWKLGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVSAAHKVCLALWVLAVINTVPYFVFRDTIPRLDGRIMCYYNVLLLSPGPDRNATCDSRQTALAVSKFLLAFAVPLAIIASSHLAVSAQLRHRGRRRSSRFVRLVAAVVAAFALCWGPYHVFSVMEARAHANPSLRPLVWRGLPFVTSLAFINSVINPLLYVLTCPDVLRKLRRSLRSVLESVLVDDSDLAAGGSNRRRRRASSTNASASSISESSGHRLHALWPARLLDWLRGDPAAPPQRDRTPSQDERGPLNRALSTTSG", "length": 414, "header": "tr|F6QLA1-1|F6QLA1_BOVIN Isoform 1 of Chemerin-like receptor 1 OS=Bos taurus OX=9913 GN=PTGDR2 PE=3 SV=3 CANONICAL=F6QLA1-1" }, "locus": { "chromosome": "29", "start_pos": 37187417, "end_pos": 37180318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053928.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053928.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052511.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052511.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:337885", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337885", "resource": "KEGG Pathway" }, { "id": "R-BTA-391908", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391908", "resource": "Reactome", "description": "Prostanoid ligand receptors" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "K7GSF2-1", "protein_name": "Chemerin-like receptor 1", "gene_name": "PTGDR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLANVTMKPLCPILEQMSRLQSHSNSSIRYIDHASVVLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLATASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTIKRLDGRIMCYYNVLLLNPGPDLDATCNSRQMALAVSKFLLAFAVPLAIIASSHVAVSAQLRQRGRRRSGRFVRLVAAVVAAFALCWGPYHVFSVLEARSHSNPELRPLVWRGLPFVTSLAFINSVVNPLLYVLTCPDVLRKLRRSLRSVLESVLVDDSELGGGGSSRRRRRASSTDASSASSSLGSRLLPQHVPARLFRWLGGSRAAPPRRDRARSQEERGPLNRALSTTSG", "length": 405 }, "evidence": [ { "id": "F6QLA1", "url": "https://omabrowser.org/oma/group/F6QLA1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6XKD3-1", "protein_name": "Prostaglandin D2 receptor 2", "gene_name": "Ptgdr2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD", "length": 403 }, "evidence": [ { "id": "F6QLA1", "url": "https://omabrowser.org/oma/group/F6QLA1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y5Y4-1", "protein_name": "Prostaglandin D2 receptor 2", "gene_name": "PTGDR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS", "length": 395 }, "evidence": [ { "id": "F6QLA1", "url": "https://omabrowser.org/oma/group/F6QLA1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2J6-1", "protein_name": "Prostaglandin D2 receptor 2", "gene_name": "Ptgdr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV", "length": 382 }, "evidence": [ { "id": "F6QLA1", "url": "https://omabrowser.org/oma/group/F6QLA1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "calcium-mediated signaling", "id": "GO:0019722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "prostaglandin D receptor activity", "id": "GO:0004956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004956", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "neuropeptide binding", "id": "GO:0042923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042923", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "icosanoid receptor activity", "id": "GO:0004953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004953", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "prostaglandin F receptor activity", "id": "GO:0004958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004958", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" }, { "name": "prostaglandin J receptor activity", "id": "GO:0001785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001785", "evidence": [ { "database": "UniProtKB", "id": "F6QLA1", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QLA1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 414, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QLA1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QLA1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QLA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QLA1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 312, "start_aa": "Glu", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 357, "end_pos": 359 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6PUJ3-1", "uniprot_ac": "F6PUJ3", "uniprot_id": "F6PUJ3_BOVIN", "mass": { "chemical_mass": 17175.0, "monoisotopic_mass": 17175.0 }, "refseq": { "ac": "XP_005212098", "name": "protein max isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212098" }, "gene_names": [ { "name": "MAX", "type": "recommended", "evidence": [ { "id": "F6PUJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ] }, { "name": "MAX", "type": "synonym", "evidence": [ { "id": "XP_005212098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212098" } ] } ], "protein_names": [ { "name": "Protein max", "type": "recommended", "evidence": [ { "id": "F6PUJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3/entry#names_and_taxonomy" } ] }, { "name": "Myc-associated factor X", "type": "synonym", "evidence": [ { "id": "F6PUJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3/entry#names_and_taxonomy" } ] }, { "name": "protein max isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005212098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212098" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAX", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3", "locus": { "chromosome": "10", "start_pos": 77202412, "end_pos": 77226633, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017994", "url": "https://www.ensembl.org/id/ENSBTAG00000017994" } ] } } ], "crossref": [ { "id": "F6PUJ3", "url": "https://alphafold.ebi.ac.uk/entry/F6PUJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11406", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11406", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540616", "url": "https://www.ncbi.nlm.nih.gov/gene/540616", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LT64", "url": "https://www.orthodb.org/?gene=A0A3Q1LT64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MV00", "url": "https://www.orthodb.org/?gene=A0A3Q1MV00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N639", "url": "https://www.orthodb.org/?gene=A0A3Q1N639", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6PUJ3", "url": "https://www.orthodb.org/?gene=F6PUJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10328", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10328", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10328:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10328:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005212098", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212098", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT64", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT64-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N639", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N639", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N639-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N639-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1I4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1I4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1I4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S320", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S320", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S320-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S320-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S852", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S852", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S852-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S852-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PUJ3-1", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS", "length": 151, "header": "tr|F6PUJ3-1|F6PUJ3_BOVIN Isoform 1 of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=3 CANONICAL=F6PUJ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT64-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT64/entry", "sequence": { "sequence": "MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQGVSLVVGIAAGLGCLKRAARSLDWSVLWESES", "length": 121, "header": "tr|A0A3Q1LT64-1|A0A3Q1LT64_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=2 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77204357, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069017.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069017.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063627.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063627.2" } ] } }, { "isoform_ac": "A0A3Q1MV00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV00/entry", "sequence": { "sequence": "VKGTRTTSLGGPSVTSSVTWQGADRACVPPLIRCCSEEADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS", "length": 177, "header": "tr|A0A3Q1MV00-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=2 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226434, "end_pos": 77203416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069877.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069877.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074577.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074577.2" } ] } }, { "isoform_ac": "A0A3Q1N639-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N639/entry", "sequence": { "sequence": "MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKGRKMKRIFPPGFLFLTFFCLGE", "length": 79, "header": "tr|A0A3Q1N639-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=2 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77145457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078615.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078615.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065865.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065865.2" } ] } }, { "isoform_ac": "A0AAA9S1I4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1I4/entry", "sequence": { "sequence": "MSDNDDIEVESDVSPGASSFPCGLSGWDSGRGSQQGDGGRGPGRRRLLPLPPLGWDPLRRAPGSLSPGSWPERPSETGGGEETRGLWDPSLPRWRKEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS", "length": 244, "header": "tr|A0AAA9S1I4-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=1 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77203416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077543.1" } ] } }, { "isoform_ac": "A0AAA9S320-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S320/entry", "sequence": { "sequence": "MSDNDDIEVESDEEQPRFQSAASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS", "length": 124, "header": "tr|A0AAA9S320-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=1 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77203416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129029.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129029.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076498.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076498.1" } ] } }, { "isoform_ac": "A0AAA9S852-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S852/entry", "sequence": { "sequence": "MTSSGRMLSWSSKGKARADQVLCSWGIHFSSSLMEDASKRKFRALEKARSSAQLQTNYPSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS", "length": 103, "header": "tr|A0AAA9S852-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=1 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77204882, "end_pos": 77203416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131341.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131341.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078333.1" } ] } }, { "isoform_ac": "A0AAA9SQV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQV3/entry", "sequence": { "sequence": "MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKLYFLFGEPCAPVPRDQSWMGQCHTFISNYQGPKIKEYRV", "length": 96, "header": "tr|A0AAA9SQV3-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=1 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77210517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092072.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092072.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085334.1" } ] } }, { "isoform_ac": "A0AAA9SZT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZT3/entry", "sequence": { "sequence": "MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQGEQWGLWGSWPCCAPARSGPRAGACRVRISDGRAPE", "length": 125, "header": "tr|A0AAA9SZT3-1|F6PUJ3_BOVIN Computationally mapped isoform of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=1 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77204735, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090486.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090486.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091987.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091987.1" } ] } }, { "isoform_ac": "F6PUJ3-1", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3/entry", "sequence": { "sequence": "MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDSSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS", "length": 151, "header": "tr|F6PUJ3-1|F6PUJ3_BOVIN Isoform 1 of Protein max OS=Bos taurus OX=9913 GN=MAX PE=3 SV=3 CANONICAL=F6PUJ3-1" }, "locus": { "chromosome": "10", "start_pos": 77226143, "end_pos": 77203416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023939.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023939.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023939.8", "url": "https://www.ensembl.org/id/ENSBTAP00000023939.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8953750", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "resource": "Reactome", "description": "Transcriptional Regulation by E2F6" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "F6PUJ3", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6PUJ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 151, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6PUJ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6PUJ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6PUJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PUJ3" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 65, "start_aa": "Asp", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2S5-1", "uniprot_ac": "F1N2S5", "uniprot_id": "F1N2S5_BOVIN", "mass": { "chemical_mass": 88057.0, "monoisotopic_mass": 88057.0 }, "refseq": { "ac": "XP_002691322", "name": "E3 ubiquitin-protein ligase SH3RF3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691322" }, "gene_names": [ { "name": "SH3RF3", "type": "recommended", "evidence": [ { "id": "F1N2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ] }, { "name": "SH3RF3", "type": "synonym", "evidence": [ { "id": "XP_002691322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691322" } ] } ], "protein_names": [ { "name": "RING-type E3 ubiquitin transferase", "type": "recommended", "evidence": [ { "id": "F1N2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S5/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "F1N2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S5/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase SH3RF3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002691322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691322" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH3RF3", "url": "https://www.uniprot.org/uniprotkb/F1N2S5", "locus": { "chromosome": "11", "start_pos": 44340406, "end_pos": 44502271, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038011", "url": "https://www.ensembl.org/id/ENSBTAG00000038011" } ] } } ], "crossref": [ { "id": "F1N2S5", "url": "https://alphafold.ebi.ac.uk/entry/F1N2S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038011", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038011", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11785", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11785", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16750", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16750", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615501", "url": "https://www.ncbi.nlm.nih.gov/gene/615501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615501", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615501", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SEMRGAM", "url": "https://omabrowser.org/oma/group/SEMRGAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NBM8", "url": "https://www.orthodb.org/?gene=A0A3Q1NBM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2S5", "url": "https://www.orthodb.org/?gene=F1N2S5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691322", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691322", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBM8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLGAPRLCASRAAAAAQREDDGDRLGGDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVSSRRELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGASPGSSPPARPGPGPSPASGAASALAGGGGSSPGSPVLLPAATGATSSLRELATSRSAPPAKGPPPPPAGKALLNFEGTEPGELRCGEGDAVVLQRRGDELWYHGLLPAGFVQSVRPLPPAPPQGKALYDFEMKDRDQDKDCLSFSKDEVLTVIRRVDDNWAEGKLRDKIGIFPLLYVELNDAAKQLMEMDKLGLASASGCLASLPSEAGAVASVAPGPSSGSTGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSTQASGHRRSMEISAPVLISSSDPRAAARIGDLAHLSRSAPAQDSSAGSTPATEQQSTTPRVQLPLNVYLALYAYKPQKSDELELRKGDTYRVLEKCRDGWFKGTALRTGLSGVFPGNYVTPVSRIPVGGAGPPRNNAVGGSPLAKGMATTMHPGGGSLSSPATALRPALPLTTAQVPAQHQAASPPLGSCLRHTVQPAASQARSAGPTAAHPAQVQGRPTATVSPLRTQNSPSRLPAGLRPPALGSPQHSPQPVTQCPRPAIPLASAASAVTPPNVSAANLNGEAGGGPASGLTASSPTSAGGRPDERKNEKKDRKSGLLKLLAGASTRRKSRSPPSTSPTHDPQAVDASLQGAVGPEVSLLSIHGRAGSCPIEGEMQGALGMEPLHRKAGSLDLSFPSPTRPAAFSTIAVRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDVVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF", "length": 844, "header": "tr|F1N2S5-1|F1N2S5_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=SH3RF3 PE=3 SV=2 CANONICAL=F1N2S5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NBM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBM8/entry", "sequence": { "sequence": "MLLGAPRLCASRAAAAAQREDDGDRLGGDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVSSRRELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGASPGSSPPARPGPGPSPASGAASALAGGGGSSPGSPVLLPAATGATSSLRELATSRSAPPAKGPPPPPAGKALLNFEGTEPGELRCGEGDAVVLQRRGDELWYHGLLPAGFVQSVRPLPPAPPQGKALYDFEMKDRDQDKDCLSFSKLNDAAKQLMEMDKLGLASASGCLASLPSEAGAVASVAPGPSSGSTGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSTQASGHRRSMEISAPVLISSSDPRAAARIGDLAHLSRSAPAQDSSAGSTPATEQQSTTPRVQLPLNVYLALYAYKPQKSDELELRKGDTYRVLEKCRDGWFKGTALRTGLSGVFPGNYVTPVSRIPVGGAGPPRNNAVGGSPLAKGMATTMHPGGGSLSSPATALRPALPLTTAQVPAQHQAASPPLGSCLRHTVQPAASQARSAGPTAAHPAQVQGRPTATVSPLRTQNSPSRLPAGLRPPALGSPQHSPQPVTQCPRPAIPLASAASAVTPPNVSAANLNGEAGGGPASGLTASSPTSAGGRPDERKNEKKDRKSGLLKLLAGASTRRKSRSPPSTSPTHDPQAVDASLQGAVGPEVSLLSIHGRAGSCPIEGEMQGALGMEPLHRKAGSLDLSFPSPTRPAAFSTIAVRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDVVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF", "length": 812, "header": "tr|A0A3Q1NBM8-1|F1N2S5_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=SH3RF3 PE=3 SV=1 CANONICAL=F1N2S5-1" }, "locus": { "chromosome": "11", "start_pos": 44502072, "end_pos": 44341410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071250.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071250.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068743.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068743.1" } ] } }, { "isoform_ac": "F1N2S5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S5/entry", "sequence": { "sequence": "MLLGAPRLCASRAAAAAQREDDGDRLGGDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVSSRRELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGASPGSSPPARPGPGPSPASGAASALAGGGGSSPGSPVLLPAATGATSSLRELATSRSAPPAKGPPPPPAGKALLNFEGTEPGELRCGEGDAVVLQRRGDELWYHGLLPAGFVQSVRPLPPAPPQGKALYDFEMKDRDQDKDCLSFSKDEVLTVIRRVDDNWAEGKLRDKIGIFPLLYVELNDAAKQLMEMDKLGLASASGCLASLPSEAGAVASVAPGPSSGSTGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSTQASGHRRSMEISAPVLISSSDPRAAARIGDLAHLSRSAPAQDSSAGSTPATEQQSTTPRVQLPLNVYLALYAYKPQKSDELELRKGDTYRVLEKCRDGWFKGTALRTGLSGVFPGNYVTPVSRIPVGGAGPPRNNAVGGSPLAKGMATTMHPGGGSLSSPATALRPALPLTTAQVPAQHQAASPPLGSCLRHTVQPAASQARSAGPTAAHPAQVQGRPTATVSPLRTQNSPSRLPAGLRPPALGSPQHSPQPVTQCPRPAIPLASAASAVTPPNVSAANLNGEAGGGPASGLTASSPTSAGGRPDERKNEKKDRKSGLLKLLAGASTRRKSRSPPSTSPTHDPQAVDASLQGAVGPEVSLLSIHGRAGSCPIEGEMQGALGMEPLHRKAGSLDLSFPSPTRPAAFSTIAVRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDVVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF", "length": 844, "header": "tr|F1N2S5-1|F1N2S5_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=SH3RF3 PE=3 SV=2 CANONICAL=F1N2S5-1" }, "locus": { "chromosome": "11", "start_pos": 44502072, "end_pos": 44341410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055080.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055080.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052653.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052653.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 416, "start_aa": "Thr", "end_pos": 416, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr416", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 487, "start_aa": "Thr", "end_pos": 487, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr487", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 575, "start_aa": "Thr", "end_pos": 575, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr575", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 639, "start_aa": "Thr", "end_pos": 639, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr639", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615501", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615501", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "M0R6D9-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Sh3rf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLGASWLCASKAAATAAPGEGDDRQGEQQRGDQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFPALAGGAGGATGSPPRSPVFLSAAAGSSTSSSLCDAATNRSVPVAKNLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGTHGFLPASYIQCMRPLPQTLPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVANVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQASSHRHSMEISAPVLISSSDPRAAARIGELAHLSCAVPTQDSSSAGPVPTAIPRAAAVAGEQGMSPKVQLPLNMYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGISGVFPGNYVTPVSRVPGGAGSPWNNVLGGSPLAKGMATIMHPGGGSLSSPATATRSALPLTTLQDHMQHPATSLPTGSCLRHTAQPAASQAGGTTIPTATHPSAQALDRPTATVSPLRTQTSPSRLPSTSLRPRSVVSPQHSQQPPTQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPTSGLSTPSPINAGYKPDDKKNEKKEKKSGLLKLLAGASTKKKARSPPSVSPTHDPQSAMDSSLQGAVGPEVSPLTIHGRAGSCPVESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSTASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHRKHEDGWFKGTLQRNGRTGLFPGSFVESF", "length": 878 }, "evidence": [ { "id": "F1N2S5", "url": "https://omabrowser.org/oma/group/F1N2S5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C120-1", "protein_name": "E3 ubiquitin-protein ligase SH3RF3", "gene_name": "Sh3rf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLGASWLCASKAAATAARGEGEDRQGEQQRGAQARTEEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGASPGSSPPARPGPGTFSALAGGAGGATGSPPCSPVFLSAAAGSSTSSLCDVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRRKVDENWYHGELQGMHGFLPASYIQCVRPLPQALPQGKALYDFEMKDRDQDKDCLTFTKDEVLTVIRRVDDNWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKLCPAATTAYNYDALLSSDPSTVASVAPGPTLSSSGAVSAFQRRVDSKKNAKKRHSFTALSVTHKSSQAASHRHSMEISAPVLISSSDPRAAARIGELAHLSCTVPTQDSSSAGPVPTALPRAAAVAGEQGMSPKVQLPLNVYLALYAYKPQKNDELELRKGEMYRVLEKCQDGWFKGASLKTGVSGVFPGNYVTPVSRVPGGGAGLPWNNVLGGSPLAKGMATIMHPGGGSLSSPATAARSALPLTTLQDHMQHPATSLPTGSCLRHSAQPTASQAGDTTIPTATHASAQALDRPTATVSPLRTQTSPSRLPSTGLRPRSVASPQHGQQSPAQMCPRPAIPFTSAASAITPPNVSAANLSGEVGGTPISGLSTPSLINTGFKPDDKKNEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQSAMDTSLQGAMGPEVSPLTVHGRAGSCPIESEMQGAIGLEPLHRKAGSLDLNFSLSPSRQATLSMASIRPEPKPLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKHEDGWFKGTLQRNGRTGLFPGSFVESF", "length": 878 }, "evidence": [ { "id": "F1N2S5", "url": "https://omabrowser.org/oma/group/F1N2S5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TEJ3-1", "protein_name": "E3 ubiquitin-protein ligase SH3RF3", "gene_name": "SH3RF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF", "length": 882 }, "evidence": [ { "id": "F1N2S5", "url": "https://omabrowser.org/oma/group/F1N2S5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N2S5", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2S5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 844, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2S5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2S5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 82, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S5" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 232, "end_pos": 295, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 416, 487, 575, 639 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 642, "end_pos": 644 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N652-1", "uniprot_ac": "F1N652", "uniprot_id": "F1N652_BOVIN", "mass": { "chemical_mass": 28646.0, "monoisotopic_mass": 28646.0 }, "refseq": {}, "gene_names": [ { "name": "GOSR2", "type": "recommended", "evidence": [ { "id": "F1N652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ] } ], "protein_names": [ { "name": "Golgi SNAP receptor complex member 2", "type": "recommended", "evidence": [ { "id": "F1N652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N652/entry#names_and_taxonomy" } ] }, { "name": "27 kDa Golgi SNARE protein", "type": "synonym", "evidence": [ { "id": "F1N652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N652/entry#names_and_taxonomy" } ] }, { "name": "Membrin", "type": "synonym", "evidence": [ { "id": "F1N652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N652/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NDZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDZ1#function" }, { "database": "UniProtKB", "id": "ARBA00037078", "url": "https://www.uniprot.org/uniprotkb/ARBA00037078#function" }, { "database": "UniProtKB", "id": "A0AAA9SCK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCK1#function" }, { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652#function" }, { "database": "UniProtKB", "id": "PIRNR028865", "url": "https://www.uniprot.org/uniprotkb/PIRNR028865#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOSR2", "url": "https://www.uniprot.org/uniprotkb/F1N652", "locus": { "chromosome": "19", "start_pos": 45277559, "end_pos": 45298404, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015958", "url": "https://www.ensembl.org/id/ENSBTAG00000015958" } ] } } ], "crossref": [ { "id": "F1N652", "url": "https://alphafold.ebi.ac.uk/entry/F1N652", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015958", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015958", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15863", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15863", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR010989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NDZ1", "url": "https://www.orthodb.org/?gene=A0A3Q1NDZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N652", "url": "https://www.orthodb.org/?gene=F1N652", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21230", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21230", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21230:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21230:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5694530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NDZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NDZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N652-1", "url": "https://www.uniprot.org/uniprotkb/F1N652-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARVGTALAGRGGGSCDRKPEAGRGAVRTCSVEAGAGPGGAGNMEPLYQQTHKHVHEIQSHMGRLETADKQALHLVENEIQASIDQIFSQLERLEILSSKEPPHKRQNAKLRVDQLKYDVQHLQTALRNFQHQRYAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKIHHGMDDLIGGGHSILEGLRAQRVTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT", "length": 255, "header": "tr|F1N652-1|F1N652_BOVIN Isoform 1 of Golgi SNAP receptor complex member 2 OS=Bos taurus OX=9913 GN=GOSR2 PE=3 SV=2 CANONICAL=F1N652-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NDZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDZ1/entry", "sequence": { "sequence": "MEPLYQQTHKHVHEIQSHMGRLETADKQALHLVENEIQASIDQIFSQLERLEILSSKEPPHKRQNAKLRVDQLKYDVQHLQTALRNFQHQRYAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKIHHGMDDLIGGGHSILEGLRAQRVTLKVGALWGDREKALCFDFSQQGPRRRSLTSPTCSACPTR", "length": 196, "header": "tr|A0A3Q1NDZ1-1|F1N652_BOVIN Computationally mapped isoform of Golgi SNAP receptor complex member 2 OS=Bos taurus OX=9913 GN=GOSR2 PE=3 SV=2 CANONICAL=F1N652-1" }, "locus": { "chromosome": "19", "start_pos": 45298076, "end_pos": 45280289, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083081.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083081.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069760.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069760.2" } ] } }, { "isoform_ac": "A0AAA9SCK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCK1/entry", "sequence": { "sequence": "MEPLYQQTHKHVHEIQSHMGRLETADKQALHLVENEIQASIDQIFSQLERLEILSSKEPPHKRQNAKLRVDQLKYDVQHLQTALRNFQHQRYAREQQERQREELLSRTFTTNVSPAPGRDQQKLGGWLELELRTLDSSSGG", "length": 141, "header": "tr|A0AAA9SCK1-1|F1N652_BOVIN Computationally mapped isoform of Golgi SNAP receptor complex member 2 OS=Bos taurus OX=9913 GN=GOSR2 PE=3 SV=1 CANONICAL=F1N652-1" }, "locus": { "chromosome": "19", "start_pos": 45298076, "end_pos": 45286998, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113573.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113573.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083847.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083847.1" } ] } }, { "isoform_ac": "F1N652-1", "url": "https://www.uniprot.org/uniprotkb/F1N652/entry", "sequence": { "sequence": "MARVGTALAGRGGGSCDRKPEAGRGAVRTCSVEAGAGPGGAGNMEPLYQQTHKHVHEIQSHMGRLETADKQALHLVENEIQASIDQIFSQLERLEILSSKEPPHKRQNAKLRVDQLKYDVQHLQTALRNFQHQRYAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKIHHGMDDLIGGGHSILEGLRAQRVTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT", "length": 255, "header": "tr|F1N652-1|F1N652_BOVIN Isoform 1 of Golgi SNAP receptor complex member 2 OS=Bos taurus OX=9913 GN=GOSR2 PE=3 SV=2 CANONICAL=F1N652-1" }, "locus": { "chromosome": "19", "start_pos": 45298205, "end_pos": 45280185, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021217.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021217.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021217.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021217.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" }, { "id": "R-BTA-5694530", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694530", "resource": "Reactome", "description": "Cargo concentration in the ER" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "ER to Golgi transport vesicle membrane", "id": "GO:0012507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012507", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "vesicle fusion", "id": "GO:0006906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006906", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "SNAP receptor activity", "id": "GO:0005484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "F1N652", "url": "https://www.uniprot.org/uniprotkb/F1N652" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N652-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 255, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N652-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N652" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N652" }, { "id": "PF27021", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BOS1/GOSR2/MEM11 N-terminal", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 150, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 170, "end_pos": 172 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1K5-1", "uniprot_ac": "F1N1K5", "uniprot_id": "F1N1K5_BOVIN", "mass": { "chemical_mass": 60583.0, "monoisotopic_mass": 60583.0 }, "refseq": { "ac": "XP_002690143", "name": "importin subunit alpha-6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690143" }, "gene_names": [ { "name": "KPNA5", "type": "recommended", "evidence": [ { "id": "F1N1K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ] }, { "name": "KPNA5", "type": "synonym", "evidence": [ { "id": "XP_002690143", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690143" } ] } ], "protein_names": [ { "name": "Importin subunit alpha", "type": "recommended", "evidence": [ { "id": "F1N1K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K5/entry#names_and_taxonomy" } ] }, { "name": "importin subunit alpha-6", "type": "synonym", "evidence": [ { "id": "XP_002690143", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690143" } ] } ], "function": [ { "annotation": "Functions in nuclear protein import.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RWE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE0#function" }, { "database": "UniProtKB", "id": "PIRNR005673", "url": "https://www.uniprot.org/uniprotkb/PIRNR005673#function" }, { "database": "UniProtKB", "id": "A0AAA9SYW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW1#function" }, { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5#function" }, { "database": "UniProtKB", "id": "A0AAA9TRL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL5#function" }, { "database": "UniProtKB", "id": "ARBA00053483", "url": "https://www.uniprot.org/uniprotkb/ARBA00053483#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KPNA5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5", "locus": { "chromosome": "9", "start_pos": 33875743, "end_pos": 33924757, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026673", "url": "https://www.ensembl.org/id/ENSBTAG00000026673" } ] } } ], "crossref": [ { "id": "F1N1K5", "url": "https://alphafold.ebi.ac.uk/entry/F1N1K5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026673", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026673", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783596", "url": "https://www.ncbi.nlm.nih.gov/gene/783596", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783596", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783596", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWSTISV", "url": "https://omabrowser.org/oma/group/NWSTISV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1K5", "url": "https://www.orthodb.org/?gene=F1N1K5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23316", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23316", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01749", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01749", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690143", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690143", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1K5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1K5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPRNDESMLENPIQDPDISSTVPIPEEEVITSDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGSNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDPSIVPQVDENQQQFVFQQQEAPMEGFQL", "length": 539, "header": "tr|F1N1K5-1|F1N1K5_BOVIN Isoform 1 of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA5 PE=3 SV=2 CANONICAL=F1N1K5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWE0/entry", "sequence": { "sequence": "MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQEEVITSDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGSNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDPSIVPQVDENQQQFVFQQQEAPMEGFQL", "length": 505, "header": "tr|A0AAA9RWE0-1|F1N1K5_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA5 PE=3 SV=1 CANONICAL=F1N1K5-1" }, "locus": { "chromosome": "9", "start_pos": 33923216, "end_pos": 33876379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094961.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094961.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076724.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076724.1" } ] } }, { "isoform_ac": "A0AAA9SYW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW1/entry", "sequence": { "sequence": "MILRETKVTFYDSAAAAAKLLQLCPTLCNPRDSSPPALPRPWDSPGKNTGVGCHFLLQCRKVKSESEVAQSCPTLSDPMDCNPPGSNAHGIFQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGSNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDPSIVPQVDENQQQFVFQQQEAPMEGFQL", "length": 487, "header": "tr|A0AAA9SYW1-1|F1N1K5_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA5 PE=3 SV=1 CANONICAL=F1N1K5-1" }, "locus": { "chromosome": "9", "start_pos": 33911362, "end_pos": 33876379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125064.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125064.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088557.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088557.1" } ] } }, { "isoform_ac": "A0AAA9TRL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL5/entry", "sequence": { "sequence": "MASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPRNDESMLENPIQDPDISSTVPIPEEEVITSDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGSNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDPSIVPQVDENQQQFVFQQQEAPMEGFQL", "length": 494, "header": "tr|A0AAA9TRL5-1|F1N1K5_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA5 PE=3 SV=1 CANONICAL=F1N1K5-1" }, "locus": { "chromosome": "9", "start_pos": 33918591, "end_pos": 33876379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111729.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111729.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099104.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099104.1" } ] } }, { "isoform_ac": "F1N1K5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1K5/entry", "sequence": { "sequence": "MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPRNDESMLENPIQDPDISSTVPIPEEEVITSDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGSNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDPSIVPQVDENQQQFVFQQQEAPMEGFQL", "length": 539, "header": "tr|F1N1K5-1|F1N1K5_BOVIN Isoform 1 of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA5 PE=3 SV=2 CANONICAL=F1N1K5-1" }, "locus": { "chromosome": "9", "start_pos": 33923216, "end_pos": 33876379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019262.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019262.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019262.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019262.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783596", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783596", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YPJ5-1", "protein_name": "Importin subunit alpha", "gene_name": "KPNA5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDIMSSPGKDNFRMKSYKNNALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPGNEESMVESPIQDPDISSTVPIPEEEVITVDMVQMIFSDDPDQQLTATQKFRKLLSKEPNPPIDEVIQKPGVVQRFVKFLERSENYTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLSSEHEDVQEQAVWALGNIAGDNAECRDFVLNCGILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPDFSKVAPCLNVLSRLLFSSDPDVLADACWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPILIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCTKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGMGINPYCALIEEAYGLDKIEFLQRHENQEIYQKAFELIEHYFGVEEEDSSIAPQVDESQQQFVFQQQEAPMEGFQL", "length": 539 }, "evidence": [ { "id": "F1N1K5", "url": "https://omabrowser.org/oma/group/F1N1K5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RTU5-1", "protein_name": "Importin subunit alpha", "gene_name": "KPNA5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPKSDESMLESPIQDPDITSTVPIPEEEVITTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSDRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHSDYKVVSPALRAVGNIVTGNDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGVNPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDPSIVPQVDENQQQFVFQQQEAPMEGFHL", "length": 539 }, "evidence": [ { "id": "F1N1K5", "url": "https://omabrowser.org/oma/group/F1N1K5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15131-1", "protein_name": "Importin subunit alpha-6", "gene_name": "KPNA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL", "length": 539 }, "evidence": [ { "id": "F1N1K5", "url": "https://omabrowser.org/oma/group/F1N1K5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q503E9-1", "protein_name": "Importin subunit alpha-6", "gene_name": "kpna5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPPGDESMLECPIQDPDVSSTVPVSGEGVITQDVIQMIFSEDPDQQLIATQKFRKLLSKEPNPPIDEVIGTPGVVNRFVEFLRRSDNCTLQFEAAWALTNIASGTFQHTKVVIETGAVPIFIELLNSEYEDVQEQAVWALGNIAGDNAECRDYVLNCGILPSLQQLLAKSNRLTTTRNAVWALSNLCRGKNPPPDFAKVSPCLSVLSRLLFSSDPDVLADACWALSYLSDGPNDKIQTVIDSGVCRRLVELLMHSDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIKKEACWTVSNITAGNRAQIQAVIDSNVFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLNTIKPMCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEEDASIVPQVDQNQGQYIFQQSEGPMEGFQL", "length": 539 }, "evidence": [ { "id": "F1N1K5", "url": "https://omabrowser.org/oma/group/F1N1K5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q56R16-1", "protein_name": "Importin subunit alpha-6", "gene_name": "Kpna5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPRNDDCMLESPIQDPDVSSTVPIPEEDMITADMIQMIFSNNAEQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIRLLTSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQVVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLGSPKESVRKEACWTISNITAGNRMQIQAVIDGSIFPVLIEVLQKAEFRTRKEAAWAITNATSGGAPEQIRYLVTLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGERESKQNGVGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIERYFGVEEDDPSLVPQVDEQQRQFLFQQCEAPGEGFQL", "length": 539 }, "evidence": [ { "id": "F1N1K5", "url": "https://omabrowser.org/oma/group/F1N1K5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" }, { "name": "NLS-dependent protein nuclear import complex", "id": "GO:0042564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042564", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" }, { "name": "NLS-bearing protein import into nucleus", "id": "GO:0006607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006607", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" }, { "name": "nuclear localization sequence binding", "id": "GO:0008139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008139", "evidence": [ { "database": "UniProtKB", "id": "F1N1K5", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1K5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 539, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1K5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1K5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K5" }, { "id": "PS51214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IBB", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 60, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 249, "end_pos": 251 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 365, "end_pos": 367 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4J3-1", "uniprot_ac": "F1N4J3", "uniprot_id": "F1N4J3_BOVIN", "mass": { "chemical_mass": 82930.0, "monoisotopic_mass": 82930.0 }, "refseq": { "ac": "NP_001192498", "name": "forkhead box protein P2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192498" }, "gene_names": [ { "name": "FOXP2", "type": "recommended", "evidence": [ { "id": "F1N4J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ] }, { "name": "FOXP2", "type": "synonym", "evidence": [ { "id": "NP_001192498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192498" } ] } ], "protein_names": [ { "name": "Forkhead box protein P2", "type": "recommended", "evidence": [ { "id": "F1N4J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J3/entry#names_and_taxonomy" } ] }, { "name": "forkhead box protein P2", "type": "synonym", "evidence": [ { "id": "NP_001192498", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192498" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FOXP2", "url": "https://www.uniprot.org/uniprotkb/F1N4J3", "locus": { "chromosome": "4", "start_pos": 53771530, "end_pos": 54345486, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011246", "url": "https://www.ensembl.org/id/ENSBTAG00000011246" } ] } } ], "crossref": [ { "id": "F1N4J3", "url": "https://alphafold.ebi.ac.uk/entry/F1N4J3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011246", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011246", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20065", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20065", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505502", "url": "https://www.ncbi.nlm.nih.gov/gene/505502", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032354", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032354", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505502", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505502", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "REYPESH", "url": "https://omabrowser.org/oma/group/REYPESH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4J3", "url": "https://www.orthodb.org/?gene=F1N4J3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45796", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45796", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45796:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45796:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192498", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4J3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4J3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQELLPETKLCVCGHSSGDGHPHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQHPGKQAKEVGSGQLIHAEEREQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHTIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 745, "header": "tr|F1N4J3-1|F1N4J3_BOVIN Isoform 1 of Forkhead box protein P2 OS=Bos taurus OX=9913 GN=FOXP2 PE=4 SV=2 CANONICAL=F1N4J3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWR3/entry", "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQHPGKQAKEQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHTIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 706, "header": "tr|A0AAA9RWR3-1|F1N4J3_BOVIN Computationally mapped isoform of Forkhead box protein P2 OS=Bos taurus OX=9913 GN=FOXP2 PE=4 SV=1 CANONICAL=F1N4J3-1" }, "locus": { "chromosome": "4", "start_pos": 54076899, "end_pos": 53771975, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096184.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096184.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077890.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077890.1" } ] } }, { "isoform_ac": "A0AAA9SXY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXY0/entry", "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQHPGKQAKEQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHTIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 708, "header": "tr|A0AAA9SXY0-1|F1N4J3_BOVIN Computationally mapped isoform of Forkhead box protein P2 OS=Bos taurus OX=9913 GN=FOXP2 PE=4 SV=1 CANONICAL=F1N4J3-1" }, "locus": { "chromosome": "4", "start_pos": 54076899, "end_pos": 53771975, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088804.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088804.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089096.1" } ] } }, { "isoform_ac": "F1N4J3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4J3/entry", "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQELLPETKLCVCGHSSGDGHPHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQHPGKQAKEVGSGQLIHAEEREQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHTIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 745, "header": "tr|F1N4J3-1|F1N4J3_BOVIN Isoform 1 of Forkhead box protein P2 OS=Bos taurus OX=9913 GN=FOXP2 PE=4 SV=2 CANONICAL=F1N4J3-1" }, "locus": { "chromosome": "4", "start_pos": 54076899, "end_pos": 53771975, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014933.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014933.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014933.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014933.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505502", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505502", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O15409-1", "protein_name": "Forkhead box protein P2", "gene_name": "FOXP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 715 }, "evidence": [ { "id": "F1N4J3", "url": "https://omabrowser.org/oma/group/F1N4J3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0CF24-1", "protein_name": "Forkhead box protein P2", "gene_name": "Foxp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQCQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSQEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 710 }, "evidence": [ { "id": "F1N4J3", "url": "https://omabrowser.org/oma/group/F1N4J3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P58463-1", "protein_name": "Forkhead box protein P2", "gene_name": "Foxp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSEKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE", "length": 714 }, "evidence": [ { "id": "F1N4J3", "url": "https://omabrowser.org/oma/group/F1N4J3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "skeletal muscle tissue development", "id": "GO:0007519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "smooth muscle tissue development", "id": "GO:0048745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048745", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" }, { "name": "vocalization behavior", "id": "GO:0071625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071625", "evidence": [ { "database": "UniProtKB", "id": "F1N4J3", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 639, "end_pos": 641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 724, "end_pos": 726, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J3" }, { "id": "PS50039", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50039" }, { "id": "PRU00089", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fork-head", "eco_id": "ECO_0000259", "start_pos": 534, "end_pos": 607, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 325, "end_pos": 327 }, { "start_pos": 585, "end_pos": 587 }, { "start_pos": 639, "end_pos": 641 }, { "start_pos": 662, "end_pos": 664 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 724, "end_pos": 726 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6PWN7-1", "uniprot_ac": "F6PWN7", "uniprot_id": "F6PWN7_BOVIN", "mass": { "chemical_mass": 45994.0, "monoisotopic_mass": 45994.0 }, "refseq": { "ac": "NP_001092328", "name": "sex hormone-binding globulin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092328" }, "gene_names": [ { "name": "SHBG", "type": "recommended", "evidence": [ { "id": "F6PWN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PWN7" } ] }, { "name": "SHBG", "type": "synonym", "evidence": [ { "id": "NP_001092328", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092328" } ] } ], "protein_names": [ { "name": "Sex hormone-binding globulin", "type": "recommended", "evidence": [ { "id": "F6PWN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PWN7/entry#names_and_taxonomy" } ] }, { "name": "sex hormone-binding globulin precursor", "type": "synonym", "evidence": [ { "id": "NP_001092328", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092328" } ] } ], "function": [ { "annotation": "Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U6#function" }, { "database": "UniProtKB", "id": "ARBA00037620", "url": "https://www.uniprot.org/uniprotkb/ARBA00037620#function" }, { "database": "UniProtKB", "id": "A0AAA9RX83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX83#function" }, { "database": "UniProtKB", "id": "A0AAA9SRZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ8#function" }, { "database": "UniProtKB", "id": "A0AAA9SSP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP0#function" }, { "database": "UniProtKB", "id": "A0AAA9TD21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD21#function" }, { "database": "UniProtKB", "id": "F6PWN7", "url": "https://www.uniprot.org/uniprotkb/F6PWN7#function" } ] }, { "annotation": "Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001092328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092328" }, { "database": "PubMed", "id": "23762392", "url": "https://glygen.org/publication/PubMed/23762392" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6PWN7", "url": "https://www.uniprot.org/uniprotkb/F6PWN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHBG", "url": "https://www.uniprot.org/uniprotkb/F6PWN7", "locus": { "chromosome": "19", "start_pos": 27350672, "end_pos": 27346147, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004226", "url": "https://www.ensembl.org/id/ENSBTAG00000004226" } ] } } ], "crossref": [ { "id": "F6PWN7", "url": "https://alphafold.ebi.ac.uk/entry/F6PWN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "404182", "url": "https://www.ncbi.nlm.nih.gov/gene/404182", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404182", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404182", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24040:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24040:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00054", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00054", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001092328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092328", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RX83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PWN7", "url": "https://www.uniprot.org/uniprotkb/F6PWN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PWN7-1", "url": "https://www.uniprot.org/uniprotkb/F6PWN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKISSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQMEVKIHGDSLLLRVDGVEVLCLRQVFGQQANNSQLIMRIALGGLLFPASDLRLPLVPALDACLRQDDWLDQQAQTSASVPTSVRSCAVESQPGIFFPPGTGAEFGLQEIPRPHAEPWAFSLDLALQLAAGSGRLLALGTPENPSWLSIHLQDQKVVLSSGSGPGLDLPLILGLRLQLNLTVSGVVLSQGAKKEILALPPTGPGSLLDLWVQPHGRLFLGALPGEATSASFCLDGLWAQGRSLDMDRAQSRSLNIWTHSCPQNPGNGSDTTH", "length": 425, "header": "tr|F6PWN7-1|F6PWN7_BOVIN Isoform 1 of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RX83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX83/entry", "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKSSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQERPLLPPFAW", "length": 163, "header": "tr|A0AAA9RX83-1|F6PWN7_BOVIN Computationally mapped isoform of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "locus": { "chromosome": "19", "start_pos": 27350534, "end_pos": 27346978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108186.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108186.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075794.1" } ] } }, { "isoform_ac": "A0AAA9S9U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9U6/entry", "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKSSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQMEVKIHGDSLLLRVDGVEVLCLRQVFGQQANNSQLIMRIALGGLLFPASDLRLPLVPALDACLRQDDWLDQQAQTSASVPTSVRSCAVESQPGIFFPPGTGAEFGLQEIPRPHAEPWAFSLDLALQLAAGSGRLLALGTPENPSWLSIHLQDQERPLLPPFAW", "length": 316, "header": "tr|A0AAA9S9U6-1|F6PWN7_BOVIN Computationally mapped isoform of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "locus": { "chromosome": "19", "start_pos": 27350534, "end_pos": 27346978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094296.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094296.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082851.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082851.1" } ] } }, { "isoform_ac": "A0AAA9SRZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ8/entry", "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKSSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQMEVKIHGDSLLLRVDGVEVLCLRQVFGQQANNSQLIMRIALGGLLFPASDLRLPLVPALDACLRQDDWLDQQAQTSASVPTSVRSCAVESQPGIFFPPGTGAEFGLQEIPRPHAEPWAFSLDLALQLAAGSGRLLALGTPENPSWLSIHLQDQKVVLSSGSGPGLDLPLILGLRLQLNLTVSGVVLSQGAKKEILALPPTGPGSLLDLWVQPHGRLFLGALPGEATSASFCLDGLWAQGRSLDMDRAQSRSLNIWTHSCPQNPGNGSDTTH", "length": 424, "header": "tr|A0AAA9SRZ8-1|F6PWN7_BOVIN Computationally mapped isoform of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "locus": { "chromosome": "19", "start_pos": 27350650, "end_pos": 27346978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127571.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127571.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089161.1" } ] } }, { "isoform_ac": "A0AAA9SSP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP0/entry", "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKSSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQMEVKIHGDSLLLRVDGVEVLCLRQVFGQQANNSQLIMRIALGGLLFPASDLRLPLVPALDACLRQDDWLDQQAQTSASVPTSVRSCAVESQPGIFFPPGTGAEFGLQGEATSASFCLDGLWAQGRSLDMDRAQSRSLNIWTHSCPQNPGNGSDTTH", "length": 309, "header": "tr|A0AAA9SSP0-1|F6PWN7_BOVIN Computationally mapped isoform of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "locus": { "chromosome": "19", "start_pos": 27350650, "end_pos": 27346978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095127.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095127.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087012.1" } ] } }, { "isoform_ac": "A0AAA9TD21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD21/entry", "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKSSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQLVPALDACLRQDDWLDQQAQTSASVPTSVRSCAVESQPGIFFPPGTGAEFGLQEIPRPHAEPWAFSLDLALQLAAGSGRLLALGTPENPSWLSIHLQDQKVVLSSGSGPGLDLPLILGLRLQLNLTVSGVVLSQGAKKEILALPPTGPGSLLDLWVQPHGRLFLGALPGEATSASFCLDGLWAQGRSLDMDRAQSRSLNIWTHSCPQNPGNGSDTTH", "length": 370, "header": "tr|A0AAA9TD21-1|F6PWN7_BOVIN Computationally mapped isoform of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "locus": { "chromosome": "19", "start_pos": 27350650, "end_pos": 27346978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125912.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125912.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094646.1" } ] } }, { "isoform_ac": "F6PWN7-1", "url": "https://www.uniprot.org/uniprotkb/F6PWN7/entry", "sequence": { "sequence": "MWKAAFPHAFAPESLEAKRGPQLIMVSRGPLAIWHGLLLLLLLPLPSHGGPALRPPLPSQTTEDSPALHLSSGPGQEPVTIMTFNLTKITKISSSFEFRTWDPEGVIFYGDTNPKNDWFMLGLRDGRPEIQLHNHWAQLTVSAGPRLDDGKWHQMEVKIHGDSLLLRVDGVEVLCLRQVFGQQANNSQLIMRIALGGLLFPASDLRLPLVPALDACLRQDDWLDQQAQTSASVPTSVRSCAVESQPGIFFPPGTGAEFGLQEIPRPHAEPWAFSLDLALQLAAGSGRLLALGTPENPSWLSIHLQDQKVVLSSGSGPGLDLPLILGLRLQLNLTVSGVVLSQGAKKEILALPPTGPGSLLDLWVQPHGRLFLGALPGEATSASFCLDGLWAQGRSLDMDRAQSRSLNIWTHSCPQNPGNGSDTTH", "length": 425, "header": "tr|F6PWN7-1|F6PWN7_BOVIN Isoform 1 of Sex hormone-binding globulin OS=Bos taurus OX=9913 GN=SHBG PE=4 SV=1 CANONICAL=F6PWN7-1" }, "locus": { "chromosome": "19", "start_pos": 27350650, "end_pos": 27346978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005537.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005537.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005537.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005537.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2.", "journal": "PloS one", "date": "2013", "authors": "Fritz S\u00e9bastien, Capitan Aurelien, Djari Anis, Rodriguez Sabrina C, Barbat Anne, Baur Aur\u00e9lia, Grohs C\u00e9cile, Weiss Bernard, Boussaha Mekki, Esquerr\u00e9 Diane, Klopp Christophe, Rocha Dominique, Boichard Didier", "evidence": [ { "database": "RefSeq", "id": "NP_001092328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092328" } ], "reference": [ { "type": "PubMed", "id": "23762392", "url": "https://glygen.org/publication/PubMed/23762392" } ] } ], "pathway": [ { "id": "bta:404182", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404182", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F6PWN7", "url": "https://www.uniprot.org/uniprotkb/F6PWN7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "steroid binding", "id": "GO:0005496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005496", "evidence": [ { "database": "UniProtKB", "id": "F6PWN7", "url": "https://www.uniprot.org/uniprotkb/F6PWN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6PWN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PWN7" }, { "id": "PS50025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin G", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 240, "start_aa": "Leu", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 419, "end_pos": 421 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4C0-1", "uniprot_ac": "F1N4C0", "uniprot_id": "F1N4C0_BOVIN", "mass": { "chemical_mass": 39241.0, "monoisotopic_mass": 39241.0 }, "refseq": { "ac": "XP_005216372", "name": "protein Wnt-11 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216372" }, "gene_names": [ { "name": "WNT11", "type": "recommended", "evidence": [ { "id": "F1N4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ] }, { "name": "WNT11", "type": "synonym", "evidence": [ { "id": "XP_005216372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216372" } ] } ], "protein_names": [ { "name": "Protein Wnt", "type": "recommended", "evidence": [ { "id": "F1N4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C0/entry#names_and_taxonomy" } ] }, { "name": "protein Wnt-11 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005216372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216372" } ] } ], "function": [ { "annotation": "Ligand for members of the frizzled family of seven transmembrane receptors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RYT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT3#function" }, { "database": "UniProtKB", "id": "RU003500", "url": "https://www.uniprot.org/uniprotkb/RU003500#function" }, { "database": "UniProtKB", "id": "A0AAA9SL37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL37#function" }, { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WNT11", "url": "https://www.uniprot.org/uniprotkb/F1N4C0", "locus": { "chromosome": "15", "start_pos": 55605313, "end_pos": 55626761, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010820", "url": "https://www.ensembl.org/id/ENSBTAG00000010820" } ] } } ], "crossref": [ { "id": "F1N4C0", "url": "https://alphafold.ebi.ac.uk/entry/F1N4C0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010820", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010820", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613288", "url": "https://www.ncbi.nlm.nih.gov/gene/613288", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CKLLPGM", "url": "https://omabrowser.org/oma/group/CKLLPGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4C0", "url": "https://www.orthodb.org/?gene=F1N4C0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238698", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086398", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086400", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086400", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005216372", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216372", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4C0-1", "url": "https://www.uniprot.org/uniprotkb/F1N4C0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRARPQVCQALLFALALQTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTIVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTSHGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 354, "header": "tr|F1N4C0-1|F1N4C0_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT11 PE=3 SV=1 CANONICAL=F1N4C0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT3/entry", "sequence": { "sequence": "MQQGPRKQWDLKYVSVRVCALKAHTYMHTLHRRPARRTSDSGRQRGWTSARLPQSETPLRARRARMRARPQVCQALLFALALQTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTIVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTSHGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 419, "header": "tr|A0AAA9RYT3-1|F1N4C0_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT11 PE=3 SV=1 CANONICAL=F1N4C0-1" }, "locus": { "chromosome": "15", "start_pos": 55624343, "end_pos": 55605964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127366.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127366.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076296.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076296.1" } ] } }, { "isoform_ac": "A0AAA9SL37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL37/entry", "sequence": { "sequence": "MASSGSLCSRPDFLFTGCFLATCRALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTIVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTSHGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 350, "header": "tr|A0AAA9SL37-1|F1N4C0_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT11 PE=3 SV=1 CANONICAL=F1N4C0-1" }, "locus": { "chromosome": "15", "start_pos": 55622608, "end_pos": 55605964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102746.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102746.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084599.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084599.1" } ] } }, { "isoform_ac": "F1N4C0-1", "url": "https://www.uniprot.org/uniprotkb/F1N4C0/entry", "sequence": { "sequence": "MRARPQVCQALLFALALQTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTIVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTSHGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 354, "header": "tr|F1N4C0-1|F1N4C0_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT11 PE=3 SV=1 CANONICAL=F1N4C0-1" }, "locus": { "chromosome": "15", "start_pos": 55622675, "end_pos": 55605964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014355.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014355.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014355.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014355.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3238698", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238698", "resource": "Reactome", "description": "WNT ligand biogenesis and trafficking" }, { "id": "R-BTA-4086398", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086398", "resource": "Reactome", "description": "Ca2+ pathway" }, { "id": "R-BTA-4086400", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086400", "resource": "Reactome", "description": "PCP/CE pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HUR9-1", "protein_name": "Protein Wnt", "gene_name": "Wnt11", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRTRPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMRTIVHAAREAMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAASISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 354 }, "evidence": [ { "id": "F1N4C0", "url": "https://omabrowser.org/oma/group/F1N4C0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V819-1", "protein_name": "Protein Wnt", "gene_name": "Wnt11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMRTIVHAAREAMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSCSIRTCWKGLQELRDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 354 }, "evidence": [ { "id": "F1N4C0", "url": "https://omabrowser.org/oma/group/F1N4C0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O96014-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 354 }, "evidence": [ { "id": "F1N4C0", "url": "https://omabrowser.org/oma/group/F1N4C0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P48615-1", "protein_name": "Protein Wnt-11", "gene_name": "Wnt11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQHCKQLEGLVSAQVQLCRSNLELMRTIVHAARGAMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK", "length": 354 }, "evidence": [ { "id": "F1N4C0", "url": "https://omabrowser.org/oma/group/F1N4C0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P49339-1", "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKPSPQFFLAAFLSLILQTGICYGIKWIALSKTPSSLALNQTQHCKQLEGLVVSQVQLCRSNLELMQTIIQAAREVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARACTTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKKSGSQANKLMHLHNSEVGRQVLKASLEMKCKCHGVSGSCSIKTCWKGLQELRDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK", "length": 354 }, "evidence": [ { "id": "F1N4C0", "url": "https://omabrowser.org/oma/group/F1N4C0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "protein kinase activator activity", "id": "GO:0030295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "frizzled binding", "id": "GO:0005109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005109", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "ventricular septum development", "id": "GO:0003281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "adrenal gland development", "id": "GO:0030325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030325", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "atrial septum development", "id": "GO:0003283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003283", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "secondary heart field specification", "id": "GO:0003139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003139", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "neuroendocrine cell differentiation", "id": "GO:0061101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061101", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "cloacal septation", "id": "GO:0060197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060197", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "embryonic skeletal system development", "id": "GO:0048706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048706", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "lung-associated mesenchyme development", "id": "GO:0060484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060484", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "mesonephric duct development", "id": "GO:0072177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072177", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "secondary palate development", "id": "GO:0062009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062009", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "ureteric bud morphogenesis", "id": "GO:0060675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060675", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "primary heart field specification", "id": "GO:0003138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003138", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" }, { "name": "cell fate commitment", "id": "GO:0045165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165", "evidence": [ { "database": "UniProtKB", "id": "F1N4C0", "url": "https://www.uniprot.org/uniprotkb/F1N4C0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4C0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4C0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4C0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N736-1", "uniprot_ac": "F1N736", "uniprot_id": "F1N736_BOVIN", "mass": { "chemical_mass": 55150.0, "monoisotopic_mass": 55150.0 }, "refseq": { "ac": "XP_005216725", "name": "protein Mdm4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216725" }, "gene_names": [ { "name": "MDM4", "type": "recommended", "evidence": [ { "id": "F1N736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ] }, { "name": "MDM4", "type": "synonym", "evidence": [ { "id": "XP_005216725", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216725" } ] } ], "protein_names": [ { "name": "Protein Mdm4", "type": "recommended", "evidence": [ { "id": "F1N736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N736/entry#names_and_taxonomy" } ] }, { "name": "protein Mdm4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005216725", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216725" } ] } ], "function": [ { "annotation": "Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M6L6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6L6#function" }, { "database": "UniProtKB", "id": "PIRNR006748", "url": "https://www.uniprot.org/uniprotkb/PIRNR006748#function" }, { "database": "UniProtKB", "id": "A0AAA9S4H8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H8#function" }, { "database": "UniProtKB", "id": "ARBA00094426", "url": "https://www.uniprot.org/uniprotkb/ARBA00094426#function" }, { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736#function" }, { "database": "UniProtKB", "id": "A0AAA9T6K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6K6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MDM4", "url": "https://www.uniprot.org/uniprotkb/F1N736", "locus": { "chromosome": "16", "start_pos": 2292885, "end_pos": 2255105, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006255", "url": "https://www.ensembl.org/id/ENSBTAG00000006255" } ] } } ], "crossref": [ { "id": "F1N736", "url": "https://alphafold.ebi.ac.uk/entry/F1N736", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16784", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16784", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17673", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17673", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514225", "url": "https://www.ncbi.nlm.nih.gov/gene/514225", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPDCRRT", "url": "https://omabrowser.org/oma/group/IPDCRRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M6L6", "url": "https://www.orthodb.org/?gene=A0A3Q1M6L6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N736", "url": "https://www.orthodb.org/?gene=F1N736", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12183", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12183", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12183:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12183:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46858", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46858", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46858:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46858:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00641", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00641", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005216725", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216725", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6L6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6L6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S245", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S245", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S245-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S245-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4H8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4H8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S585", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S585", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S585-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S585-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6K6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3D2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3D2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3D2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N736-1", "url": "https://www.uniprot.org/uniprotkb/F1N736-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATDAAQTLAIAQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGVGKKVEAADPEQTSEEVGKLIDKKVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 491, "header": "tr|F1N736-1|F1N736_BOVIN Isoform 1 of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=3 CANONICAL=F1N736-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6L6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6L6/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPRFSFCFTCYPDAAQTLAIAQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGVGKKVEAADPEQTSEEVGKLIDKKVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 482, "header": "tr|A0A3Q1M6L6-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2292591, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071973.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071973.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065639.1" } ] } }, { "isoform_ac": "A0AAA9S245-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S245/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATEMDHFICQISHIFSH", "length": 129, "header": "tr|A0AAA9S245-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2281415, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131556.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131556.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076160.1" } ] } }, { "isoform_ac": "A0AAA9S4H8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H8/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATDAAQTLAIAQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 441, "header": "tr|A0AAA9S4H8-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2292591, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126639.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126639.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080064.1" } ] } }, { "isoform_ac": "A0AAA9S585-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S585/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 268, "header": "tr|A0AAA9S585-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2292591, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119339.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119339.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077320.1" } ] } }, { "isoform_ac": "A0AAA9SN58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN58/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATGD", "length": 116, "header": "tr|A0AAA9SN58-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2290068, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135530.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135530.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084254.1" } ] } }, { "isoform_ac": "A0AAA9SZE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE4/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGVGKKVEAADPEQTSEEVGKLIDKKVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 393, "header": "tr|A0AAA9SZE4-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2292591, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131276.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131276.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089465.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089465.1" } ] } }, { "isoform_ac": "A0AAA9T6K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6K6/entry", "sequence": { "sequence": "MQTSRHFTAKMTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATDAAQTLAIAQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGVGKKVEAADPEQTSEEVGKLIDKKVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 501, "header": "tr|A0AAA9T6K6-1|F1N736_BOVIN Computationally mapped isoform of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2292591, "end_pos": 2255469, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092376.1" } ] } }, { "isoform_ac": "A0ABI0P3D2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3D2/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATAKCRGKFQFQEKNRRQYSHTAYLTV", "length": 139, "header": "tr|A0ABI0P3D2-1|A0ABI0P3D2_BOVIN Computationally mapped isoform of MDM4 regulator of p53 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=1 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2285198, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148053.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148053.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105230.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105230.1" } ] } }, { "isoform_ac": "F1N736-1", "url": "https://www.uniprot.org/uniprotkb/F1N736/entry", "sequence": { "sequence": "MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVALATAATDAAQTLAIAQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGVGKKVEAADPEQTSEEVGKLIDKKVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA", "length": 491, "header": "tr|F1N736-1|F1N736_BOVIN Isoform 1 of Protein Mdm4 OS=Bos taurus OX=9913 GN=MDM4 PE=3 SV=3 CANONICAL=F1N736-1" }, "locus": { "chromosome": "16", "start_pos": 2292591, "end_pos": 2275595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008209.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008209.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008209.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008209.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A480E269-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDKMTSFSTSAQCSTSDSACRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSVEESSNSRKRTEEDNIPALPTSQHKCKNSREDEDVVENLTQDETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGIGIKVEAADTEQTSEEVGKVRDKKVIEVGKNDDLEDSKSIDDDTDIEVTSEDEWQCTECKKYNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQENEGIDVPDCRRTISAPVVRPKDTYVKEEKPKCFGPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA", "length": 494 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LH52-1", "protein_name": "Protein Mdm4", "gene_name": "Mdm4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSHSSSAQCSTSDNACRISSERISQQVRPKLPLLKILQTAGAQGEVFTMKEVMHYLGQYIMVKQLYDQREQHMVYCGGDLLGDLLGRQSFSVKDPSPLYDMLRKNLVTSVPVNTDAAQTLALAQDHSMDIPSQDRLKRSATECSNSRKRNEEDDTLTLPTSQHKRRDSRGDEDLVEHLTQDETCRLDLDFEEWDVAGLPWWFLGNLRNNYIPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEELGVGIKVEAASSEQASEVGKASDKKMVEVGKDDDAEDLKSLSDDTDVELTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCPKLTHSLSTSNITAIHEKKDNEGIDVPDCRRTISAPVVRPKDTYLKEENIKFDPCNSVKFLDLAHSSESQETISSMREQADILSEQKMDTESMEDYHNILKLCSLCEKRPRDGNIIHGRTSHLTTCFQCARRLKKTGASCPSCKKQIQLVIKVFIA", "length": 490 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1ADE5-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTSSSSAQHPAAENACRITLGQANQVRPKLPLLKILQAAGAQGETFTLKEVMHYLGQYIMVRQLYDKRQQHMVYCGGDQLGELLGLESFSVKDPSPVYEMLKRNLTSAAMTDAAQNLAKEQSVDKPSQDQLKFSPKEGSDTVIMGDESNASAVSTSEHKCENYEDKDLIENLSKSKKPKLDLVFEEWDVAGLPWWFLGNLRSNYKSRSNGSTDIQTNQDIDTAIVSDTTDDLWFLNESPLDQTNTAVKMETADCEEVKEGDKKVTEDACLHDFEDSQCLSDDTDTEAASEDCWQCTKCKKFNSPGKRYCYRCWALRKDWYSDCPKLTHSLSLSNIDAMQNENSDEGIDVPDCRRTISAPVGPPKDMYVVENKSHVDPCGSIESLDLARECERRDSLLSFTEHKKEEEIQSLESIKKLLNPCFLCHHRPRDGNIVHGRTAHLVACFKCAKMLKKRRSPCPVCRKDIEMVIRIFMG", "length": 474 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O15151-1", "protein_name": "Protein Mdm4", "gene_name": "MDM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA", "length": 490 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35618-1", "protein_name": "Protein Mdm4", "gene_name": "Mdm4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSHSTSAQCSASDSACRISSEQISQVRPKLQLLKILHAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASINTDAAQTLALAQDHTMDFPSQDRLKHGATEYSNPRKRTEEEDTHTLPTSRHKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNCIPKSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGIKVEAANSEQTSEVGKTSNKKTVEVGKDDDLEDSRSLSDDTDVELTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVGFLDLAHSSESQEIISSAREQTDIFSEQKAETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA", "length": 489 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5XIN1-1", "protein_name": "Protein Mdm4", "gene_name": "Mdm4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSHSTSAQCSASDSACRISSEQINQQVRPKLQLLKILQAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHLVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASVNTDAAQTLALAQDHTMDIPSQDRLKHGATECSNPRKRTEEDDTHTLPTSRRKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNYIPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGVKVEAANCEQPSEVGRTRDKKMVEGGKDDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVEFLDLAHGSESQEIISSTREQTDIFSEQKTETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA", "length": 490 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7ZUW7-1", "protein_name": "Protein Mdm4", "gene_name": "mdm4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA", "length": 496 }, "evidence": [ { "id": "F1N736", "url": "https://omabrowser.org/oma/group/F1N736/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "DNA damage response, signal transduction by p53 class mediator", "id": "GO:0030330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030330", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "negative regulation of signal transduction by p53 class mediator", "id": "GO:1901797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901797", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle", "id": "GO:0045931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045931", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N736", "url": "https://www.uniprot.org/uniprotkb/F1N736" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N736-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 491, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N736-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N736" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N736" }, { "id": "PS51925", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51925" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DM2", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 108, "start_aa": "Asn", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N736" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 438, "end_pos": 479, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N736" }, { "id": "PS50199", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RanBP2-type", "eco_id": "ECO_0000259", "start_pos": 300, "end_pos": 329, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 242, "end_pos": 244 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7K8-1", "uniprot_ac": "F1N7K8", "uniprot_id": "F1N7K8_BOVIN", "mass": { "chemical_mass": 58997.0, "monoisotopic_mass": 58997.0 }, "refseq": {}, "gene_names": [ { "name": "ALDH6A1", "type": "recommended", "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ] } ], "protein_names": [ { "name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "type": "recommended", "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8/entry#names_and_taxonomy" } ] }, { "name": "1.2.1.27", "type": "synonym", "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8/entry#names_and_taxonomy" } ] }, { "name": "Aldehyde dehydrogenase family 6 member A1", "type": "synonym", "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDI5#function" }, { "database": "UniProtKB", "id": "ARBA00060189", "url": "https://www.uniprot.org/uniprotkb/ARBA00060189#function" }, { "database": "UniProtKB", "id": "A0AAA9T7S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S8#function" }, { "database": "UniProtKB", "id": "A0A3Q1LN22", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN22#function" }, { "database": "UniProtKB", "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALDH6A1", "url": "https://www.uniprot.org/uniprotkb/F1N7K8", "locus": { "chromosome": "10", "start_pos": 85399255, "end_pos": 85447592, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018469", "url": "https://www.ensembl.org/id/ENSBTAG00000018469" } ] } } ], "crossref": [ { "id": "F1N7K8", "url": "https://alphafold.ebi.ac.uk/entry/F1N7K8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018469", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018469", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07085", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07085", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR010061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GGAKNHI", "url": "https://omabrowser.org/oma/group/GGAKNHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LN22", "url": "https://www.orthodb.org/?gene=A0A3Q1LN22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7K8", "url": "https://www.orthodb.org/?gene=F1N7K8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43866", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43866", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43866:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43866:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70895", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "20804", "url": "https://www.rhea-db.org/rhea/20804", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "76615", "url": "https://www.rhea-db.org/rhea/76615", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "76623", "url": "https://www.rhea-db.org/rhea/76623", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "76627", "url": "https://www.rhea-db.org/rhea/76627", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LN22", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN22-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7K8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7K8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENLVINPSSFLLVKGKREVKQLTNISIVFIFFLPQPTVKLFIDGKFIESKSDKWIDIHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILLVERQSCLFLPLPLFVLDSLSFRFIFRDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTNFYGKQGIQFYTQLKTITSQWKEEDASLSSPAVVMPTMGR", "length": 538, "header": "tr|F1N7K8-1|F1N7K8_BOVIN Isoform 1 of Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Bos taurus OX=9913 GN=ALDH6A1 PE=3 SV=3 CANONICAL=F1N7K8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN22-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN22/entry", "sequence": { "sequence": "MAAVAVAAAAAALRARILQVSSKVNSSWQPASSFSSSSVPTVKLFIDGKFIESKSDKWIDIHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVERAKKLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTNFYGKQFGRGKQNFHFWE", "length": 515, "header": "tr|A0A3Q1LN22-1|A0A3Q1LN22_BOVIN Computationally mapped isoform of Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Bos taurus OX=9913 GN=ALDH6A1 PE=3 SV=2 CANONICAL=F1N7K8-1" }, "locus": { "chromosome": "10", "start_pos": 85447558, "end_pos": 85428698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072479.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072479.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058160.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058160.2" } ] } }, { "isoform_ac": "A0AAA9SDI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDI5/entry", "sequence": { "sequence": "MAAVAVAAAAAALRARILQVSSKVNSSWQPASSFSSSSVPTVKLFIDGKFIESKSDKWIDIHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVERAKKLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTNFYGKQGIQFYTQLKTITSQWKEEDASLSSPAVVMPTMGR", "length": 537, "header": "tr|A0AAA9SDI5-1|F1N7K8_BOVIN Computationally mapped isoform of Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Bos taurus OX=9913 GN=ALDH6A1 PE=3 SV=1 CANONICAL=F1N7K8-1" }, "locus": { "chromosome": "10", "start_pos": 85447558, "end_pos": 85429921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128278.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128278.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081890.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081890.1" } ] } }, { "isoform_ac": "A0AAA9T7S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7S8/entry", "sequence": { "sequence": "MAAVAVAAAAAALRARILQVSSKVNSSWQPASSFSSSSVPTVKLFIDGKFIESKSDKWIDIHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVERAKKLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTNFYGKQSTS", "length": 506, "header": "tr|A0AAA9T7S8-1|F1N7K8_BOVIN Computationally mapped isoform of Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Bos taurus OX=9913 GN=ALDH6A1 PE=3 SV=1 CANONICAL=F1N7K8-1" }, "locus": { "chromosome": "10", "start_pos": 85447558, "end_pos": 85400259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099644.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099644.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091907.1" } ] } }, { "isoform_ac": "F1N7K8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7K8/entry", "sequence": { "sequence": "MENLVINPSSFLLVKGKREVKQLTNISIVFIFFLPQPTVKLFIDGKFIESKSDKWIDIHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILLVERQSCLFLPLPLFVLDSLSFRFIFRDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDTNFYGKQGIQFYTQLKTITSQWKEEDASLSSPAVVMPTMGR", "length": 538, "header": "tr|F1N7K8-1|F1N7K8_BOVIN Isoform 1 of Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Bos taurus OX=9913 GN=ALDH6A1 PE=3 SV=3 CANONICAL=F1N7K8-1" }, "locus": { "chromosome": "10", "start_pos": 85438693, "end_pos": 85429921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024584.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024584.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024584.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024584.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 535, "start_aa": "Thr", "end_pos": 535, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr535", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-70895", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "resource": "Reactome", "description": "Branched-chain amino acid catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N1P2-1", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "Aldh6a1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAVAAAAAAAAVRTRILQVSSKVNTWHLASSFSSSSVPTVKLFIDGKFVESKSDRWIDIHNPATNEIIGRVPQSTKAEMDAAVAACKRAFSAWADTSILSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLLMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAIVCGNTFLMKPSERVPGATMLLAKLFQDAGTPDGALNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVDRAKNLRVNAGDQPGADLGPLITPQAKERVCSLIDSGTKEGATILLDGRKIKVKGYENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR", "length": 536 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XYN4-1", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "ALDH6A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAAAARGVWGGRRRVAFRLPRRAGVPWIASAAASSSSVPTTKLFIDGKFVESKTTEWIDIHNPATNEVVARVPKATTSEMEAAVASCKKAFWNWSETSVLSRQQIFLRYQQLIKDNLKEISKLITFEQGKTLADAEGDVFRGLQVVEHACSVTSLILGETMPSITKDMDTCTYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGALMFLAKLFQDAGAPDGTLNIIHGQHEAVNFICDHPDIRAISFVGSNQAGEYIYERGSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAQKWLPELVERAKNLRVNAGDQPGADLGPLISPQAKERVCHLIQKGVEEGASLLLDGRNIKVKGYENGNFVGPTILANVKPNMTCYKEEIFGPVLVVLEADTLDDAIEVVNNNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRASFRGDANFYGKQGVQFYTQLKTIISQWKEEDATVTKPAVVMPTMGN", "length": 538 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S3H1-1", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "ALDH6A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVLAAAAVRARILQVSSKVNSSWHPASSFSSSSVPTVKLFIGGKFIESKSDKWIDIHNPATNELIGRVPQATKAEMDAAVSSCKRAFPAWADTSILSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNVIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVERAKNLRVNAGDQPGADLGPLISPQAKERVCNLIDSGTKEGASILLDGRNIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR", "length": 534 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q02252-1", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "ALDH6A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR", "length": 535 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q02253-1", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "Aldh6a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAVAAAAAVRSRILQVSSKVNSTWYPASSFSSSSVPTVKLFIDGKFVESKSDKWIDIHNPATNEVVGRVPQSTKAEMEAAVAACKRAFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVERAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGAKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIFTTNGAIARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR", "length": 535 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0WM29-1", "protein_name": "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "ALDH6B2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVRVKQKNLESYRSNGTYPPTWRNPTTSFAPDQHRVSIHSSLKSKTKRRRLYKEADDNTKLRSSSSTTTTTTTMLLRISGNNLRPLRPQFLALRSSWLSTSPEQSTQPQMPPRVPNLIGGSFVESQSSSFIDVINPATQEVVSKVPLTTNEEFKAAVSAAKQAFPLWRNTPITTRQRVMLKFQELIRKNMDKLAMNITTEQGKTLKDSHGDIFRGLEVVEHACGMATLQMGEYLPNVSNGVDTYSIREPLGVCAGICPFNFPAMIPLWMFPVAVTCGNTFILKPSEKDPGASVILAELAMEAGLPDGVLNIVHGTNDTVNAICDDEDIRAVSFVGSNTAGMHIYARAAAKGKRIQSNMGAKNHGLVLPDANIDATLNALLAAGFGAAGQRCMALSTVVFVGDAKSWEDKLVERAKALKVTCGSEPDADLGPVISKQAKERICRLIQSGVDDGAKLLLDGRDIVVPGYEKGNFIGPTILSGVTPDMECYKEEIFGPVLVCMQANSFDEAISIINKNKYGNGAAIFTSSGAAARKFQMDIEAGQIGINVPIPVPLPFFSFTGNKASFAGDLNFYGKAGVDFFTQIKTVTQQWKDIPTSVSLAMPTSQKQ", "length": 607 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54I10-1", "protein_name": "Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "mmsdh", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLSFKFAKSASKVIGNRNFHSSSASLANTTKLFINGKFVESKTKEWLEVRNPATQELVTKVPVSTKEEMEAAVKAASDAFPAWRDTSVSNRSRIISNYKNLINKNMDKIAAIITEEQGKTLPDAKGDVFRGLEVVEHSVNVASLMMGETVENVSKNVDIYSYVQPLGVCAGITPFNFPAMIPLWMFPLAIACGNTFVLKPSERVPSASMFLVQLAQEAGVPDGVVNVIHGGKEAVNFICDAPEVRAISFVGADQAGRHIHARGTANGKRVQSNMAAKNHATIVPDAHKERTLDALTGAAFGASGQRCMALSAAVFVGESKNWIPELAERAKKLKVAGGAAPGADLGPVISAASKQRIHELIQSGIDEGAKCILDGRNVVVDPEFSKGNFVGPTILTDVKPHMRCYKEEIFGPVLVCLNVDTVDQAIQLINANPYGNGTAVFTSSGAVARKYQREIDVGQVGINLPIPVPLPFFSFTGSRGSFVGAGHFYGKTGVQFFTQIKTITSNWRDDDISHGVSSSMNMPILGKN", "length": 528 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7KW39-1", "protein_name": "Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLVRLIGAEARHLAKRSYSSAAPTTKLFIDGKFVESKTNEWIDVHDPATNQVVTRVPKATQAEMQAALESNKKAFRSWSNQSILTRQQVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQMGETVANVARDMDTYSLVLPLGVTAGVAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGATMLLMELLNEAGCPPGVVNVIHGQHDAVNFICDAPEIKAVSFVGSDQAGKYIYERAGKNGKRVQSNMGAKNHGIILGDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQAWIPDLVERAQKLKVNAGHVPGTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKITVPGYEDGYFVGPTILSDVTPSMKCYTEEIFGPVLVILKADTLDDAIGIVNANPYGNGTAVFTTNGAAARKFVNEIDAGQVGVNVPIPVPLPMFSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRKTDVTHTQAAVAMPTMK", "length": 520 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9EQ20-1", "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "Aldh6a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVAAAAAMRSRILQVSSKVNATWYPASSFSSSSVPTVKLFIDGKFVESKSDKWIDIHNPATNEVVGRVPQSTKAEMDAAVESCKRAFPAWADTSILSRQQVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHDAVNFICDHPDIKAISFVGSNQAGEYIFERGSRNGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVDRAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRRIKVKGYENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIFTTNGATARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR", "length": 535 }, "evidence": [ { "id": "F1N7K8", "url": "https://omabrowser.org/oma/group/F1N7K8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "id": "GO:0004491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004491", "evidence": [ { "database": "UniProtKB", "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "thymine catabolic process", "id": "GO:0006210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006210", "evidence": [ { "database": "UniProtKB", "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ], "pmid": "" }, { "name": "L-valine catabolic process", "id": "GO:0006574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006574", "evidence": [ { "database": "UniProtKB", "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N7K8", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20804", "name": "", "equation": "2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N7K8-1", "Q07536-1" ], "evidence": [ { "id": "20804", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20804" } ] }, { "id": "76615", "name": "", "equation": "3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N7K8-1", "Q07536-1" ], "evidence": [ { "id": "76615", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76615" } ] }, { "id": "76623", "name": "", "equation": "(R)-2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q07536-1", "F1N7K8-1" ], "evidence": [ { "id": "76623", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76623" } ] }, { "id": "76627", "name": "", "equation": "(S)-2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q07536-1", "F1N7K8-1" ], "evidence": [ { "id": "76627", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76627" } ] }, { "id": "R-BTA-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N7K8-1" ], "evidence": [ { "id": "R-BTA-70893", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70893" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1N7K8", "gene_name": "ALDH6A1", "activity": [ { "ec_number": "1.2.1.27", "activity": "2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+).", "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ] }, { "ec_number": "1.2.1.27", "activity": "", "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" } ] } ] }, { "uniprot_ac": "Q07536", "gene_name": "ALDH6A1", "activity": [ { "ec_number": "1.2.1.27", "activity": "2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+).", "evidence": [ { "id": "Q07536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07536" } ] }, { "ec_number": "1.2.1.27", "activity": "", "evidence": [ { "id": "Q07536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07536" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7K8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 538, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7K8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7K8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K8" }, { "id": "PF00171", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aldehyde dehydrogenase", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 515, "start_aa": "Phe", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.2.1.27", "ec_name": "2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+).", "evidence": [ { "id": "1.2.1.27", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.27" }, { "id": "1.2.1.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.1.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 535 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 25, "end_pos": 27 }, { "start_pos": 413, "end_pos": 415 }, { "start_pos": 448, "end_pos": 450 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QGQ5-1", "uniprot_ac": "F6QGQ5", "uniprot_id": "F6QGQ5_BOVIN", "mass": { "chemical_mass": 56257.0, "monoisotopic_mass": 56257.0 }, "refseq": { "ac": "NP_001069657", "name": "dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" }, "gene_names": [ { "name": "ALG10", "type": "recommended", "evidence": [ { "id": "F6QGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ] }, { "name": "ALG10B", "type": "synonym", "evidence": [ { "id": "NP_001069657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" } ] }, { "name": "ALG10", "type": "synonym", "evidence": [ { "id": "NP_001069657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" } ] } ], "protein_names": [ { "name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "type": "recommended", "evidence": [ { "id": "F6QGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.256", "type": "synonym", "evidence": [ { "id": "F6QGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5/entry#names_and_taxonomy" } ] }, { "name": "asparagine-linked glycosylation 10 homolog (yeast, alpha-1,2-glucosyltransferase)", "type": "synonym", "evidence": [ { "id": "NP_001069657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" } ] }, { "name": "asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)", "type": "synonym", "evidence": [ { "id": "NP_001069657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" } ] }, { "name": "asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog", "type": "synonym", "evidence": [ { "id": "NP_001069657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" } ] }, { "name": "dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase A", "type": "synonym", "evidence": [ { "id": "NP_001069657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657" } ] } ], "function": [ { "annotation": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN2#function" }, { "database": "UniProtKB", "id": "ARBA00044727", "url": "https://www.uniprot.org/uniprotkb/ARBA00044727#function" }, { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALG10", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5", "locus": { "chromosome": "5", "start_pos": 76106724, "end_pos": 76113238, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030632", "url": "https://www.ensembl.org/id/ENSBTAG00000030632" } ] } } ], "crossref": [ { "id": "F6QGQ5", "url": "https://alphafold.ebi.ac.uk/entry/F6QGQ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030632", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539837", "url": "https://www.ncbi.nlm.nih.gov/gene/539837", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539837", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539837", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VWDSKIT", "url": "https://omabrowser.org/oma/group/VWDSKIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6QGQ5", "url": "https://www.orthodb.org/?gene=F6QGQ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12989", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12989", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12989:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12989:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04922", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04922", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069657", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29543", "url": "https://www.rhea-db.org/rhea/29543", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SIN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QGQ5-1", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAGMAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLLSVGVVKPASWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLLRKVQPRHKASSCIQRILSTLTLAIFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSALLGFCGFMFRQTNIIWAIFCAGNVIAQKLTEAWKTELQKKKEERPTPIKGPFSEFRKILQFLLAYSMSFKNLSMLLLLTWPYILLMFLFCAFVAVNGGIVIGDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSLNKIRAFLCLVWKRRIQFFVITLVSIFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYEIVKYLLVPVYIFAGWSIADSLKSKSIFWNLMFFICLFTVTVPQKLLEFRYFILPYVIYRLNIPLPPTSRLVCELGCYAVVNFLTFYIFLNKTFQWPNSQDIQRFMW", "length": 478, "header": "tr|F6QGQ5-1|F6QGQ5_BOVIN Isoform 1 of Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Bos taurus OX=9913 GN=ALG10 PE=3 SV=1 CANONICAL=F6QGQ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN2/entry", "sequence": { "sequence": "MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLLSVGVVKPASWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLLRKVQPRHKAYF", "length": 126, "header": "tr|A0AAA9SIN2-1|F6QGQ5_BOVIN Computationally mapped isoform of Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Bos taurus OX=9913 GN=ALG10 PE=3 SV=1 CANONICAL=F6QGQ5-1" }, "locus": { "chromosome": "5", "start_pos": 76113120, "end_pos": 76106727, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100285.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100285.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082405.1" } ] } }, { "isoform_ac": "F6QGQ5-1", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5/entry", "sequence": { "sequence": "MGAGMAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLLSVGVVKPASWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLLRKVQPRHKASSCIQRILSTLTLAIFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSALLGFCGFMFRQTNIIWAIFCAGNVIAQKLTEAWKTELQKKKEERPTPIKGPFSEFRKILQFLLAYSMSFKNLSMLLLLTWPYILLMFLFCAFVAVNGGIVIGDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSLNKIRAFLCLVWKRRIQFFVITLVSIFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYEIVKYLLVPVYIFAGWSIADSLKSKSIFWNLMFFICLFTVTVPQKLLEFRYFILPYVIYRLNIPLPPTSRLVCELGCYAVVNFLTFYIFLNKTFQWPNSQDIQRFMW", "length": 478, "header": "tr|F6QGQ5-1|F6QGQ5_BOVIN Isoform 1 of Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Bos taurus OX=9913 GN=ALG10 PE=3 SV=1 CANONICAL=F6QGQ5-1" }, "locus": { "chromosome": "5", "start_pos": 76113132, "end_pos": 76108750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000043297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040876.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040876.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539837", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539837", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IC41-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "LOC100753866", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGRFSLSQWDPMITTLPGLYLVSVGVVKPANWILGWSEHIVCSIGMLRFVNLLFSVGNFYLLYLLFRKIQPRNKASSSIQRILSTLTLALFPTLYFFNFLYYTEPGSVFFTLFAYLMCLYGNHRTSALLGFCGFMFRQTNIIWAAFCAGHIIAQKFSEAWKTELQKKKEERLPSIKGPFSELRRVLQFLLVYSMSFKNLSMLFLLTWPYILLLVAFFVFVIVNGGIVIGDRSSHEACFHFPQLFYFFSFTVFFSFPHLLSPTKVKTFFSLIWKRRVQFSVIMLVSVFLVWKFTYVHKYLLADNRHYTFYVWKRVFQRHEVVKYLLVPAYMFAGWTIADSLKSKSIFWNLMFLVCLVTSTVPQKLLEFRYFILPYIIYRLNIPLPPISRLVCELGCYTVVNFLTFYIFLNKTFQWPDNQDVQRFMW", "length": 474 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E7FEB7-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "alg10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MERFEVYIFTALCSVNFLISCLLFSKITREQRDPYMDEIFHVPQAQKYCEGKFTEWDPMITTLPGLYLASVGLIRPVVWLADLKGRVVCSTAMLRFINLLFNSGNLYILYLIICKLHMKDKSRSASRRMLSALVLSTFPVLYFFTFLYYTDSGSTFFTLFMYLMALYGCHKVAALLGICAVLFRQTNIIWVAFCASMVVAQKLDETWRTDQSKKRDEKLPSQVPLTINGAIRVMRFLLDFLISPNNIKAVVLSTWPYIAVAFGFAFFVVLNEGIVVGDRSSHEACLNFPQFFYFLSFTLIFSLSTSLSYQRAVRFLQALKKQPLVYSFLMLTFLFLIWKFTFVHKYLLADNRHFPFYVWKNIFRRHDAVRYLLVPGYVFAMWNFLDTLRSKSLFWCLAFCACLVAATVPQKLLEFRYFIIPYLLYRVNISVPSLPRLFLEFSLYTAVNAATVYIFIYKTFQWPNNTAVQRFMW", "length": 473 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LNP0-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "ALG10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGAGMAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLLSVGVVKPANWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFRKVQPRHKAASSIQRILSTLTLAVFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSALLGFCGFMFRQTNIIWAIFCAGNVISQKLTEAWKTELQKKKEERLPPIKGPFSEFRKILQFLLAYSMSFKNLSILFLLTWPYILLMFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSLSKIRAFLCLVWKRKIQFFVITLVSIFLVWKFTYAHKYLLSDNRHYTFYVWKRVFQKYEIVKYLLVPVYIFAGWTIADSLKSKSIFWNLMFFICLFTVIVPQKLLEFRYFILPYVIYRLNIPLPPTSRLVCELGCYAVVNFLTFYIFLNKTFQWPNSQDIQRFMW", "length": 478 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O88788-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "Alg10b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGRFSLSQWDPMITTLPGLYLVSVGVVKPASWILGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFRKIQPRNKASSSIQRILSTLTLAVFPTLYFFNFLYYTEAGSVFFTLFAYLMCLYGNHRTSALLGFCGFMFRQTNIIWAAFCAGHIIAQKCSEAWKTELQKKKEERLPPAKGPLSELRRVLQFLLMYSMSLKNLSMLFLLTWPYMLLLLAFFVFVVVNGGIVVGDRSSHEACLHFPQLFYFFSFTAFFSFPHLLSPTKVKTFLSLVWKRRVQFSVITLVSVFLVWKFTYVHKYLLADNRHYTFYVWKRVFQRHEIVKYLLVPAYMFAGWAVADSLKSKSIFWNLMFFVCLVASTVPQKLLEFRYFILPYIIYRLNMPLPPISRLVCELGCYAVVNFLTFYIFLNKTFQWSDSHDIQRFMW", "length": 474 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P50076-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "DIE2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDAKKNTGEANNDVLEEEAAIQLIAPGIARNLTQEVITGIFCNVVIYPLLLIYFVLTFRYMTTNIVPYEFIDEKFHVGQTLTYLKGKWTQWDPKITTPPGIYILGLINYYCIKPIFKSWSTLTILRLVNLLGGIIVFPILVLRPIFLFNALGFWPVSLMSFPLMTTYYYLFYTDVWSTILILQSLSCVLTLPFGPVKSIWLSAFFAGVSCLFRQTNIIWTGFIMILAVERPAILQKQFNTHTFNNYLKLFIHAIDDFSNLVLPYMINFVLFFIYLIWNRSITLGDKSSHSAGLHIVQIFYCFTFITVFSLPIWISRNFMKLYKLRIKRKPVQTFFEFIGIMLIIRYFTKVHPFLLADNRHYTFYLFRRLIGNKSRLIKYFFMTPIYHFSTFAYLEVMRPNQLTFHPITPLPIKEPVHLPIQLTHVSWTALITCTMVTIVPSPLFEPRYYILPYFFWRIFITCSCEPLIKDLKPAKEGENPITISSTKRLFMEFLWFMLFNVVTLVIFSKVSFPWTTEPYLQRIIW", "length": 525 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q3UGP8-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "Alg10b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGRFSLSQWDPMITTLPGLYLVSVGVVKPASWLLGWSEHVICSIGVLRFVNLLFSVGNFYLLYLLFRKVQPRNKASSSIQRILSTLTLAVFPTLYFFNFLYYTEAGSVFFTLFAYLMCLYGNHRTSALLGFCGFMFRQTNIIWAAFCAGHLIAQKCSEAWKIELQKKKEERLAPTKGPLSELRRVLQFLLVYAMSLKNLRMLFLLTWPYVLLLLAFFAFVVVNGGIVVGDRSSHEACLHFPQLFYFFSFTAFFSFPHLLSLTKVKTFLSLVWKRRVQFSVVTLVSILLVWKFTYVHKYLLADNRHYTFYVWKRVFQRHEVVKYLLVPAYIFAGWAIADSLKAKSIFWNLMFFVCLVASTVPQKLLEFRYFILPYIIYRLNIPLPPISRLVCELGCYTVVNFVTFYIFLNKTFQWPNSQDIQRFMW", "length": 474 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54Z56-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "alg10", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKLQSIQNDVLKICKVIGIIMIISLSILKIINSNQIEPYVDEIFHIPQTIKYCEFKFKEWDNKITTLPGLYILALIYSNILSMFGIGDGIWISHCSVVVLRSFNVFCLIITFFSIYEILKISTYNLLLSPASSLSSLKINQKEVIENKNSINNTIILRTIHLSIFPIFYFFHFLFYTDVVSTCSIFLTLLFSLKNKFNLSSFFGLISVTIRQTNIIWVFFITINNILKLYEENKEKQNYIFKELNLIKDIIEFIKFSIFNLLLIIKKFIGFIMVGILFLIFLYYNGSIVVGDKSNHESSFHVSQLFYFSLITMLFSLPSILISSLLKRFGNQNEGNQNENEKKILLYDPIEFLKNINFKYLIVIIIGMVLMIWKFTYTHLFLLSDNRHYTFYIWNRFIEKYSIGRYLPIPFYCYSIWFIWKVLSENRSKLWCIFYFLSTAMVLLPSPLVEPRYYIVPFFLFQLNQFHYYNNFIIQNGTIGRFFY", "length": 485 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5BKT4-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase A", "gene_name": "ALG10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLVSIGVIKPAIWIFGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFCKVQPRNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKEDRLPPIKGPFAEFRKILQFLLAYSMSFKNLSMLLLLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFTLFFSFPHLLSPSKIKTFLSLVWKRRILFFVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYETVKYLLVPAYIFAGWSIADSLKSKSIFWNLMFFICLFTVIVPQKLLEFRYFILPYVIYRLNIPLPPTSRLICELSCYAVVNFITFFIFLNKTFQWPNSQDIQRFMW", "length": 473 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8L638-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "ALG10", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGKLAVAAITSLWVIPMSIIVNHIVPEPYMDEIFHVPQAQQYCNGNFRSWDPMITTPPGLYYLSLAHVASLFPGMLLMENTSQSFSEACSTSVLRSTNAVSAVLCGVLVYEIIRFLGPNLSDRKATFMALVMSLYPLHWFFTFLYYTDVASLTAVLAMYLTCLKRRYVLSALFGTLAVFIRQTNVVWMLFVACSGILDFTLDSSKQKGKQEVNQELHQSSNKKGATLRSNLRKRKSDISSDTSDPFNHGQTVPSTEDTSDLVYDIYTVISTSWNLKWRILIKFSPFIFVVVAFGIFILWNGGIVLGAKEAHVVSLHFAQIMYFSLVSALFTAPLHFSVNQLRHQFHQLHRNWSLSLILTLVALVAGFVSVHFFSLAHPYLLADNRHYPFYLWRKIINAHWLMKYILVPVYVYSWFSILTLLAKTRRQTWILVYFLATCGVLVPTPLIEFRYYTIPFYLFMLHSCVRSSSFATWLLIGTIFVSINVFTMAMFLFRPFKWSHEDGVQRFIW", "length": 509 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8T8L8-1", "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "Alg10", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNGSWKLILPVGFVLYSLPLFLRVNGTSDYVIDEEFHIPQGLAFCRKEFDVWDPKITTFPGLYLIALLLNPLSLCTVTGLRMLSLAGAGINILLLYKIRRRILAGSGGNSYAAHEAITMSVLPPLYFFSHLYYTDTLSLTMVLLFYNYWQQEAHLPAAVFGAASVLMRQTNIVWVCMATGMTVLDTLVNQCARTGRVPKENVRLMGKELWLQLVSSPQLLCNCILSILAKCCFYASIILPFVGFLFINGSIVVGDKSAHEASLHVPQLFYFAIFAAGFGISNTIRQFRPAAELIRRNRVLSLLALLLILVVVHLNTEVHPYLLADNRHYTFYIWSRLYGRFWWFRYAMAPAYLLSICVLFCGLRHMPESFKLMFPLSLFLVLCFQRLLELRYFLVPYILFRLNTRHTRKGYAEWLELGAHLLLNVATFYVYFTKEFYWKNYRTPQRIIW", "length": 449 }, "evidence": [ { "id": "F6QGQ5", "url": "https://omabrowser.org/oma/group/F6QGQ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "id": "GO:0106073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106073", "evidence": [ { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "dolichol-linked oligosaccharide biosynthetic process", "id": "GO:0006488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006488", "evidence": [ { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ], "pmid": "" }, { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "F6QGQ5", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29543", "name": "", "equation": "an alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6QGQ5-1" ], "evidence": [ { "id": "29543", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29543" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F6QGQ5", "gene_name": "ALG10", "activity": [ { "ec_number": "2.4.1.256", "activity": "an alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+).", "evidence": [ { "id": "F6QGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ] }, { "ec_number": "2.4.1.256", "activity": "", "evidence": [ { "id": "F6QGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGQ5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QGQ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 478, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QGQ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QGQ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.1.256", "ec_name": "an alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+).", "evidence": [ { "id": "2.4.1.256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.256" }, { "id": "2.4.1.256", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.256" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 462, "end_pos": 464 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N693-1", "uniprot_ac": "F1N693", "uniprot_id": "F1N693_BOVIN", "mass": { "chemical_mass": 167275.0, "monoisotopic_mass": 167275.0 }, "refseq": { "ac": "XP_024841041", "name": "homeobox protein cut-like 1 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841041" }, "gene_names": [ { "name": "CUX1", "type": "recommended", "evidence": [ { "id": "F1N693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ] }, { "name": "CUX1", "type": "synonym", "evidence": [ { "id": "XP_024841041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841041" } ] } ], "protein_names": [ { "name": "Homeobox protein cut-like", "type": "recommended", "evidence": [ { "id": "F1N693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N693/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein cut-like 1 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_024841041", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841041" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CUX1", "url": "https://www.uniprot.org/uniprotkb/F1N693", "locus": { "chromosome": "25", "start_pos": 34703184, "end_pos": 35053237, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010659", "url": "https://www.ensembl.org/id/ENSBTAG00000010659" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523683", "url": "https://www.ncbi.nlm.nih.gov/gene/523683", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLJ6", "url": "https://www.orthodb.org/?gene=A0A3Q1LLJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M822", "url": "https://www.orthodb.org/?gene=A0A3Q1M822", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N693", "url": "https://www.orthodb.org/?gene=F1N693", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14043", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14043", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14043:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14043:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14043:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14043:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02376", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02376", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08172", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08172", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25398", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25398", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841041", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841041", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M822", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M822", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M822-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M822-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P698", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P698", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P698-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P698-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N693-1", "url": "https://www.uniprot.org/uniprotkb/F1N693-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGPLPASPPSQLPRNTGEQASNTNGTHQFSPAGLTQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASSGGSADDAIRSILQQARREMEAQQAALEPALKPAPPSQTDITLLTPKLIPASPMSSVSSYSPLAVSLKKPPSAPDASAPALPNPPALKKESQDAPGPDLPGAADPTTQGVLRHVKSELGRGTVWKDHWWSAVQPERKSSAPPEDPKAEDASSSKEKGSGGQTRAERSQLQGPSSSEYWKDWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPLSKPTKPSVPPLTPEQYEIYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIETSKDSKPPEPSDPPASDSQPATPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEAAEGPGAADAEESGGPAAAAKSQGGPAEAAAAPEEREEAPRPAEKAEPPPSGTPVPDAAADEGRPRAPPPPPEGPADGPGPVPNPAAAAAPAAGEDAATSAAPPGEGPCRARDGADRSSALPSTSAPAAARRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF", "length": 1534, "header": "tr|F1N693-1|F1N693_BOVIN Isoform 1 of Homeobox protein cut-like OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=3 CANONICAL=F1N693-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLJ6/entry", "sequence": { "sequence": "MAANVGSMFQYWKRFDLQQLQDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVHVTELTATAAEQRELIARLEQDLSTIQSIQRPDAEGAAELGLEKIPEPIKEATALFYGPSAPASSLPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTIQALQTELDSLRADNIKLFEKIKFLQSYPGRGGGSDDTELRYSTQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHLLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDKGVAAGDLWQ", "length": 638, "header": "tr|A0A3Q1LLJ6-1|A0A3Q1LLJ6_BOVIN Computationally mapped isoform of Protein CASP OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=2 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35052578, "end_pos": 34703992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087199.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087199.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060651.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060651.2" } ] } }, { "isoform_ac": "A0A3Q1M822-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M822/entry", "sequence": { "sequence": "MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVHVTELTATAAEQRELIARLEQDLSTIQSIQRPDAEGAAELGLEKIPEPIKEATALFYGPSAPASSLPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTIQALQTELDSLRADNIKLFEKIKFLQSYPGRGGGSDDTELRYSTQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHLLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDKGVAAGDLWQ", "length": 677, "header": "tr|A0A3Q1M822-1|F1N693_BOVIN Computationally mapped isoform of Homeobox protein cut-like OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=2 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35052578, "end_pos": 34703992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071467.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071467.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066571.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066571.2" } ] } }, { "isoform_ac": "A0AAA9SE89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE89/entry", "sequence": { "sequence": "MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVHVTELTATAAEQRELIARLEQDLSTIQSIQRPDAEGAAELGLEKIPEPIKEATALFYGPSAPASSLPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTIQALQTELDSLRADNIKLFEKIKFLQSYPGRGGGSDDTELRYSTQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHLLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDKGVAAGDLWQ", "length": 631, "header": "tr|A0AAA9SE89-1|F1N693_BOVIN Computationally mapped isoform of Homeobox protein cut-like OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=1 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35052578, "end_pos": 34703992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109071.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109071.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083717.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083717.1" } ] } }, { "isoform_ac": "A0AAA9SJ86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ86/entry", "sequence": { "sequence": "MESAAGPLRNAYPDRVLESKAPGVPLDSGVPGRGPRTQPQAPRGDRAGAPHPSPEPQPCPGSAFLPATPHPGEQRALGVRLGPASSALAAPGQPRDSARWMLCVAGAKLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVHVTELTATAAEQRELIARLEQDLSTIQSIQRPDAEGAAELGLEKIPEPIKEATALFYGPSAPASSLPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTIQALQTELDSLRADNIKLFEKIKFLQSYPGRGGGSDDTELRYSTQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHLLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDKGVAAGDLWQ", "length": 766, "header": "tr|A0AAA9SJ86-1|F1N693_BOVIN Computationally mapped isoform of Homeobox protein cut-like OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=1 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35051221, "end_pos": 34703992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117327.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117327.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085397.1" } ] } }, { "isoform_ac": "A0AAA9TE15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE15/entry", "sequence": { "sequence": "MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVHVTELTATAAEQRELIARLEQDLSTIQSIQRPDAEGAAELGLEKIPEPIKEATALFYGPSAPASSLPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTIQALQTELDSLRADNIKLFEKIKFLQSYPGRGGGSDDTELRYSTQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHLLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDKGVAAGDLWQ", "length": 661, "header": "tr|A0AAA9TE15-1|F1N693_BOVIN Computationally mapped isoform of Homeobox protein cut-like OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=1 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35052578, "end_pos": 34703992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097324.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097324.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095014.1" } ] } }, { "isoform_ac": "A0ABI0P698-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P698/entry", "sequence": { "sequence": "MSGDDSSPRKDYWRAGCCKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVHVTELTATAAEQRELIARLEQDLSTIQSIQRPDAEGAAELGLEKIPEPIKEATALFYGPSAPASSLPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTIQALQTELDSLRADNIKLFEKIKFLQSYPGRGGGSDDTELRYSTQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHLLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDKGVAAGDLWQ", "length": 675, "header": "tr|A0ABI0P698-1|A0ABI0P698_BOVIN Computationally mapped isoform of Protein CASP OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=1 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35062402, "end_pos": 34703992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149069.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149069.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107422.1" } ] } }, { "isoform_ac": "F1N693-1", "url": "https://www.uniprot.org/uniprotkb/F1N693/entry", "sequence": { "sequence": "MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQTLQTALEKTRTELFDLKTKYDEEITAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEAELAAKEREIAQLVEDVQRLQANLSKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPAEGAGTQDASRPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGPLPASPPSQLPRNTGEQASNTNGTHQFSPAGLTQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASSGGSADDAIRSILQQARREMEAQQAALEPALKPAPPSQTDITLLTPKLIPASPMSSVSSYSPLAVSLKKPPSAPDASAPALPNPPALKKESQDAPGPDLPGAADPTTQGVLRHVKSELGRGTVWKDHWWSAVQPERKSSAPPEDPKAEDASSSKEKGSGGQTRAERSQLQGPSSSEYWKDWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPLSKPTKPSVPPLTPEQYEIYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIETSKDSKPPEPSDPPASDSQPATPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEAAEGPGAADAEESGGPAAAAKSQGGPAEAAAAPEEREEAPRPAEKAEPPPSGTPVPDAAADEGRPRAPPPPPEGPADGPGPVPNPAAAAAPAAGEDAATSAAPPGEGPCRARDGADRSSALPSTSAPAAARRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF", "length": 1534, "header": "tr|F1N693-1|F1N693_BOVIN Isoform 1 of Homeobox protein cut-like OS=Bos taurus OX=9913 GN=CUX1 PE=3 SV=3 CANONICAL=F1N693-1" }, "locus": { "chromosome": "25", "start_pos": 35052578, "end_pos": 34728534, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014098.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014098.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014098.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014098.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "F1N693", "url": "https://www.uniprot.org/uniprotkb/F1N693" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N693" }, { "id": "PS51042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUT", "eco_id": "ECO_0000259", "start_pos": 553, "end_pos": 640, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N693" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 1249, "end_pos": 1309, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 272, "end_pos": 274 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 346, "end_pos": 348 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 457, "end_pos": 459 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 666, "end_pos": 668 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q3C5-1", "uniprot_ac": "F6Q3C5", "uniprot_id": "F6Q3C5_BOVIN", "mass": { "chemical_mass": 57610.0, "monoisotopic_mass": 57610.0 }, "refseq": { "ac": "XP_059739588", "name": "sodium-dependent lysophosphatidylcholine symporter 1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739588" }, "gene_names": [ { "name": "MFSD2A", "type": "recommended", "evidence": [ { "id": "F6Q3C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ] }, { "name": "MFSD2A", "type": "synonym", "evidence": [ { "id": "XP_059739588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739588" } ] }, { "name": "MFSD2", "type": "synonym", "evidence": [ { "id": "XP_059739588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739588" } ] } ], "protein_names": [ { "name": "Sodium-dependent lysophosphatidylcholine symporter 1", "type": "recommended", "evidence": [ { "id": "F6Q3C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5/entry#names_and_taxonomy" } ] }, { "name": "Major facilitator superfamily domain-containing protein 2A", "type": "synonym", "evidence": [ { "id": "F6Q3C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5/entry#names_and_taxonomy" } ] }, { "name": "sodium-dependent lysophosphatidylcholine symporter 1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_059739588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739588" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFSD2A", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5", "locus": { "chromosome": "3", "start_pos": 106122952, "end_pos": 106135921, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013054", "url": "https://www.ensembl.org/id/ENSBTAG00000013054" } ] } } ], "crossref": [ { "id": "F6Q3C5", "url": "https://alphafold.ebi.ac.uk/entry/F6Q3C5", "database": "AlphaFoldDB", "categories": [] }, { "id": "512633", "url": "https://www.ncbi.nlm.nih.gov/gene/512633", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11328", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11328", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11328:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11328:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739588", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739588", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "43856", "url": "https://www.rhea-db.org/rhea/43856", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43860", "url": "https://www.rhea-db.org/rhea/43860", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43864", "url": "https://www.rhea-db.org/rhea/43864", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43868", "url": "https://www.rhea-db.org/rhea/43868", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44376", "url": "https://www.rhea-db.org/rhea/44376", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SP22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q3C5-1", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKGEGAESGSAAGLLPTGILQAGERPVQKEPKKKKQLSICNKLCYAVGGAPYQVTGCALGFFLQIYLLDVAQVDPFSASIILFVGRAWDAITDPLVGFCISKSPWTRLGRLMPWITFSTPLAIIAYFLIWFVPDFHQGQTLWYLLFYCLFETLVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVLGTAIQGQIVGQADSPCIPDANASTVNRTQSSTSIKETQNAYLLAAGVIASIYVICAVILILGVREQRESYETQQTKQMPFFRGLRLVMSHGPYIKLIAGFLFTSLAFMLVEGNFALFCTYTLGFRNEFQNLLLAIMFSATVTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMESNLIVTYVVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHIHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFTGYQTRGCSQPARVKFTLKMLVTMAPIVLILIGLLLFKLYPIDEEKRRQNKKALQALREEASSSGCSDTDSTELASIL", "length": 522, "header": "tr|F6Q3C5-1|F6Q3C5_BOVIN Isoform 1 of Sodium-dependent lysophosphatidylcholine symporter 1 OS=Bos taurus OX=9913 GN=MFSD2A PE=3 SV=1 CANONICAL=F6Q3C5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP22/entry", "sequence": { "sequence": "MAKGEGAESGSAAGLLPTGILQAGERPVQVKEPKKKKQLSICNKLCYAVGGAPYQVTGCALGFFLQIYLLDVAQVDPFSASIILFVGRAWDAITDPLVGFCISKSPWTRLGRLMPWITFSTPLAIIAYFLIWFVPDFHQGQTLWYLLFYCLFETLVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVLGTAIQGQIVGQADSPCIPDANASTVNRTQSSTSIKETQNAYLLAAGVIASIYVICAVILILGVREQRESYETQQTKQMPFFRGLRLVMSHGPYIKLIAGFLFTSLAFMFSATVTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMESNLIVTYVVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHIHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFTGYQTRGCSQPARVKFTLKMLVTMAPIVLILIGLLLFKLYPIDEEKRRQNKKALQALREEASSSGCSDTDSTELASIL", "length": 495, "header": "tr|A0AAA9SP22-1|F6Q3C5_BOVIN Computationally mapped isoform of Sodium-dependent lysophosphatidylcholine symporter 1 OS=Bos taurus OX=9913 GN=MFSD2A PE=3 SV=1 CANONICAL=F6Q3C5-1" }, "locus": { "chromosome": "3", "start_pos": 106135618, "end_pos": 106123411, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096073.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096073.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084634.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084634.1" } ] } }, { "isoform_ac": "F6Q3C5-1", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5/entry", "sequence": { "sequence": "MAKGEGAESGSAAGLLPTGILQAGERPVQKEPKKKKQLSICNKLCYAVGGAPYQVTGCALGFFLQIYLLDVAQVDPFSASIILFVGRAWDAITDPLVGFCISKSPWTRLGRLMPWITFSTPLAIIAYFLIWFVPDFHQGQTLWYLLFYCLFETLVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVLGTAIQGQIVGQADSPCIPDANASTVNRTQSSTSIKETQNAYLLAAGVIASIYVICAVILILGVREQRESYETQQTKQMPFFRGLRLVMSHGPYIKLIAGFLFTSLAFMLVEGNFALFCTYTLGFRNEFQNLLLAIMFSATVTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMESNLIVTYVVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHIHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFTGYQTRGCSQPARVKFTLKMLVTMAPIVLILIGLLLFKLYPIDEEKRRQNKKALQALREEASSSGCSDTDSTELASIL", "length": 522, "header": "tr|F6Q3C5-1|F6Q3C5_BOVIN Isoform 1 of Sodium-dependent lysophosphatidylcholine symporter 1 OS=Bos taurus OX=9913 GN=MFSD2A PE=3 SV=1 CANONICAL=F6Q3C5-1" }, "locus": { "chromosome": "3", "start_pos": 106135618, "end_pos": 106123411, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017353.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017353.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017353.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017353.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "lysophospholipid transport", "id": "GO:0051977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051977", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "carbohydrate transport", "id": "GO:0008643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008643", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "lipid transport across blood-brain barrier", "id": "GO:1990379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990379", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "establishment of blood-brain barrier", "id": "GO:0060856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060856", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "hippocampus development", "id": "GO:0021766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021766", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "transcytosis", "id": "GO:0045056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045056", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "lysophospholipid translocation", "id": "GO:0140329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140329", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "regulation of phosphatidylcholine metabolic process", "id": "GO:0150172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150172", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "lysophospholipid:sodium symporter activity", "id": "GO:0051978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051978", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "lysophosphatidylcholine flippase activity", "id": "GO:0140348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140348", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" }, { "name": "oleate transmembrane transporter activity", "id": "GO:1901480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901480", "evidence": [ { "database": "UniProtKB", "id": "F6Q3C5", "url": "https://www.uniprot.org/uniprotkb/F6Q3C5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "43856", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "43856", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43856" } ] }, { "id": "43860", "name": "", "equation": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "43860", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43860" } ] }, { "id": "43864", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "43864", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43864" } ] }, { "id": "43868", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "43868", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43868" } ] }, { "id": "44376", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "44376", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44376" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 }, { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N339-1", "uniprot_ac": "F1N339", "uniprot_id": "F1N339_BOVIN", "mass": { "chemical_mass": 67854.0, "monoisotopic_mass": 67854.0 }, "refseq": { "ac": "XP_059732385", "name": "tyrosine-protein phosphatase non-receptor type 11 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732385" }, "gene_names": [ { "name": "PTPN11", "type": "recommended", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "name": "PTPN11", "type": "synonym", "evidence": [ { "id": "XP_059732385", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732385" } ] } ], "protein_names": [ { "name": "Tyrosine-protein phosphatase non-receptor type", "type": "recommended", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339/entry#names_and_taxonomy" } ] }, { "name": "tyrosine-protein phosphatase non-receptor type 11 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_059732385", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732385" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTPN11", "url": "https://www.uniprot.org/uniprotkb/F1N339", "locus": { "chromosome": "17", "start_pos": 61735552, "end_pos": 61802222, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002048", "url": "https://www.ensembl.org/id/ENSBTAG00000002048" } ] } } ], "crossref": [ { "id": "F1N339", "url": "https://alphafold.ebi.ac.uk/entry/F1N339", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002048", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002048", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09931", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09931", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14605", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14605", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533590", "url": "https://www.ncbi.nlm.nih.gov/gene/533590", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N339", "url": "https://www.orthodb.org/?gene=F1N339", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46559", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46559", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46559:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46559:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1059683", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1059683", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-109704", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110056", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110056", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-114604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1257604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1295596", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1295596", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433557", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-180292", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-180292", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-186763", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-210990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-210993", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210993", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389513", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389948", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389948", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432142", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432142", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-512988", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-512988", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654693", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654693", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654700", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654700", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654710", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654710", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654712", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654712", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654720", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654720", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654726", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654726", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654727", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654727", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654732", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654732", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654733", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654733", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854691", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8865999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8865999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8934593", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934593", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-912694", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912694", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-936964", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-936964", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9674555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059732385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732385", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9ST00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N339-1", "url": "https://www.uniprot.org/uniprotkb/F1N339-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR", "length": 592, "header": "tr|F1N339-1|F1N339_BOVIN Isoform 1 of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=4 CANONICAL=F1N339-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST00/entry", "sequence": { "sequence": "MWDPSSPAMRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR", "length": 598, "header": "tr|A0AAA9ST00-1|F1N339_BOVIN Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=1 CANONICAL=F1N339-1" }, "locus": { "chromosome": "17", "start_pos": 61783019, "end_pos": 61736478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099100.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099100.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087246.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087246.1" } ] } }, { "isoform_ac": "A0AAA9TK15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK15/entry", "sequence": { "sequence": "MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR", "length": 468, "header": "tr|A0AAA9TK15-1|F1N339_BOVIN Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=1 CANONICAL=F1N339-1" }, "locus": { "chromosome": "17", "start_pos": 61801942, "end_pos": 61736478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120165.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120165.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096598.1" } ] } }, { "isoform_ac": "A0AAA9TLS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLS8/entry", "sequence": { "sequence": "MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAECELSPSP", "length": 578, "header": "tr|A0AAA9TLS8-1|F1N339_BOVIN Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=1 CANONICAL=F1N339-1" }, "locus": { "chromosome": "17", "start_pos": 61801942, "end_pos": 61735555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089729.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089729.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099383.1" } ] } }, { "isoform_ac": "A0AAA9TTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTU5/entry", "sequence": { "sequence": "MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQTLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR", "length": 555, "header": "tr|A0AAA9TTU5-1|F1N339_BOVIN Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=1 CANONICAL=F1N339-1" }, "locus": { "chromosome": "17", "start_pos": 61801942, "end_pos": 61736478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101777.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101777.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099961.1" } ] } }, { "isoform_ac": "F1N339-1", "url": "https://www.uniprot.org/uniprotkb/F1N339/entry", "sequence": { "sequence": "MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDAKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLTDQASGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR", "length": 592, "header": "tr|F1N339-1|F1N339_BOVIN Isoform 1 of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN11 PE=3 SV=4 CANONICAL=F1N339-1" }, "locus": { "chromosome": "17", "start_pos": 61801942, "end_pos": 61736478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002653.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002653.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002653.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002653.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 565, "start_aa": "Thr", "end_pos": 565, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr565", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1059683", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1059683", "resource": "Reactome", "description": "Interleukin-6 signaling" }, { "id": "R-BTA-109704", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "resource": "Reactome", "description": "PI3K Cascade" }, { "id": "R-BTA-110056", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110056", "resource": "Reactome", "description": "MAPK3 (ERK1) activation" }, { "id": "R-BTA-114604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114604", "resource": "Reactome", "description": "GPVI-mediated activation cascade" }, { "id": "R-BTA-1257604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-BTA-1295596", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1295596", "resource": "Reactome", "description": "Spry regulation of FGF signaling" }, { "id": "R-BTA-1433557", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433557", "resource": "Reactome", "description": "Signaling by SCF-KIT" }, { "id": "R-BTA-180292", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-180292", "resource": "Reactome", "description": "GAB1 signalosome" }, { "id": "R-BTA-186763", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "resource": "Reactome", "description": "Downstream signal transduction" }, { "id": "R-BTA-210990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210990", "resource": "Reactome", "description": "PECAM1 interactions" }, { "id": "R-BTA-210993", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210993", "resource": "Reactome", "description": "Tie2 Signaling" }, { "id": "R-BTA-389513", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389513", "resource": "Reactome", "description": "Co-inhibition by CTLA4" }, { "id": "R-BTA-389948", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389948", "resource": "Reactome", "description": "Co-inhibition by PD-1" }, { "id": "R-BTA-432142", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432142", "resource": "Reactome", "description": "Platelet sensitization by LDL" }, { "id": "R-BTA-512988", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-512988", "resource": "Reactome", "description": "Interleukin-3, Interleukin-5 and GM-CSF signaling" }, { "id": "R-BTA-5654689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654689", "resource": "Reactome", "description": "PI-3K cascade:FGFR1" }, { "id": "R-BTA-5654693", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654693", "resource": "Reactome", "description": "FRS-mediated FGFR1 signaling" }, { "id": "R-BTA-5654695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654695", "resource": "Reactome", "description": "PI-3K cascade:FGFR2" }, { "id": "R-BTA-5654700", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654700", "resource": "Reactome", "description": "FRS-mediated FGFR2 signaling" }, { "id": "R-BTA-5654706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654706", "resource": "Reactome", "description": "FRS-mediated FGFR3 signaling" }, { "id": "R-BTA-5654710", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654710", "resource": "Reactome", "description": "PI-3K cascade:FGFR3" }, { "id": "R-BTA-5654712", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654712", "resource": "Reactome", "description": "FRS-mediated FGFR4 signaling" }, { "id": "R-BTA-5654720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654720", "resource": "Reactome", "description": "PI-3K cascade:FGFR4" }, { "id": "R-BTA-5654726", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654726", "resource": "Reactome", "description": "Negative regulation of FGFR1 signaling" }, { "id": "R-BTA-5654727", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654727", "resource": "Reactome", "description": "Negative regulation of FGFR2 signaling" }, { "id": "R-BTA-5654732", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654732", "resource": "Reactome", "description": "Negative regulation of FGFR3 signaling" }, { "id": "R-BTA-5654733", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654733", "resource": "Reactome", "description": "Negative regulation of FGFR4 signaling" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-8853659", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "resource": "Reactome", "description": "RET signaling" }, { "id": "R-BTA-8854691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "resource": "Reactome", "description": "Interleukin-20 family signaling" }, { "id": "R-BTA-8865999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8865999", "resource": "Reactome", "description": "MET activates PTPN11" }, { "id": "R-BTA-8934593", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934593", "resource": "Reactome", "description": "Regulation of RUNX1 Expression and Activity" }, { "id": "R-BTA-912694", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912694", "resource": "Reactome", "description": "Regulation of IFNA/IFNB signaling" }, { "id": "R-BTA-936964", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-936964", "resource": "Reactome", "description": "Activation of IRF3, IRF7 mediated by TBK1, IKK\u03b5 (IKBKE)" }, { "id": "R-BTA-9674555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674555", "resource": "Reactome", "description": "Signaling by CSF3 (G-CSF)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "atrioventricular canal development", "id": "GO:0036302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036302", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "genitalia development", "id": "GO:0048806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048806", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "ERBB signaling pathway", "id": "GO:0038127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038127", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "negative regulation of T cell proliferation", "id": "GO:0042130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042130", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "negative regulation of cell adhesion mediated by integrin", "id": "GO:0033629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033629", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "face morphogenesis", "id": "GO:0060325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060325", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of D-glucose import", "id": "GO:0046326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046326", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of insulin receptor signaling pathway", "id": "GO:0046628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046628", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "inner ear development", "id": "GO:0048839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048839", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "regulation of protein-containing complex assembly", "id": "GO:0043254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043254", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "negative regulation of chondrocyte differentiation", "id": "GO:0032331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032331", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of lipopolysaccharide-mediated signaling pathway", "id": "GO:0031666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031666", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of ossification", "id": "GO:0045778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045778", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "negative regulation of neutrophil activation", "id": "GO:1902564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902564", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "receptor tyrosine kinase binding", "id": "GO:0030971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "peptide hormone receptor binding", "id": "GO:0051428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051428", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "signaling receptor complex adaptor activity", "id": "GO:0030159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030159", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N339", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-BTA-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "A0A3Q1LUE0-1", "F1MN51-1", "F1MYM3-1", "F1MRU0-1", "F1N339-1", "F1MTL5-1", "F1MNW2-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-109699", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109699" } ] }, { "id": "R-BTA-109857", "name": "MAP2K1 binds MAPK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SXH6-1", "F1MCX4-1", "F1N339-1", "E1B8P9-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-109857", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109857" } ] }, { "id": "R-BTA-1112690", "name": "PTPN11 binds CBL", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "A0AAA9SXH6-1", "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-1112690", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1112690" } ] }, { "id": "R-BTA-1112703", "name": "PTPN11 is phosphorylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SXH6-1", "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-1112703", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1112703" } ] }, { "id": "R-BTA-1112708", "name": "PTPN11 binds p-Y759-IL6ST", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SXH6-1", "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-1112708", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1112708" } ] }, { "id": "R-BTA-1433428", "name": "GRB2 is indirectly recruited to p-KIT through SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-1433428", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433428" } ] }, { "id": "R-BTA-1433454", "name": "Phosphorylation of GAB2 by SFKs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-1433454", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433454" } ] }, { "id": "R-BTA-1433488", "name": "Phosphorylation of SHP2 by SFKs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-1433488", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433488" } ] }, { "id": "R-BTA-1433514", "name": "Synthesis of PIP3 from PIP2 by PI3K", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-1433514", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433514" } ] }, { "id": "R-BTA-1549564", "name": "PPTN11 dephosphorylates SPRY2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P67774-1", "Q0P594-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-1549564", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1549564" } ] }, { "id": "R-BTA-1562641", "name": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-1562641", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1562641" } ] }, { "id": "R-BTA-166271", "name": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S7G8-1", "A0AAA9TWW0-1", "F1MQ36-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-166271", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166271" } ] }, { "id": "R-BTA-177923", "name": "Sustained activation of SRC kinase by SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-BTA-180499" ], "enzyme_list": [ "Q0VBZ0-1", "F1N339-1", "A0A3Q1MHB0-1", "E1BIM8-1" ], "evidence": [ { "id": "R-BTA-177923", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177923" } ] }, { "id": "R-BTA-177924", "name": "Dephosphorylation of Gab1 by SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0A3Q1MHB0-1" ], "evidence": [ { "id": "R-BTA-177924", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177924" } ] }, { "id": "R-BTA-177926", "name": "Dephosphorylation of PAG by SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-BTA-180494" ], "output_participant_list": [ "R-BTA-180500" ], "enzyme_list": [ "F1N339-1", "A0A3Q1MHB0-1" ], "evidence": [ { "id": "R-BTA-177926", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177926" } ] }, { "id": "R-BTA-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0A3Q1MHB0-1" ], "evidence": [ { "id": "R-BTA-177935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177935" } ] }, { "id": "R-BTA-177944", "name": "Activation of SHP2 through the binding to phospho-Gab1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0A3Q1MHB0-1" ], "evidence": [ { "id": "R-BTA-177944", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177944" } ] }, { "id": "R-BTA-186778", "name": "SHP2 binds to the active receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MX49-1", "F1N339-1", "F1N759-1" ], "evidence": [ { "id": "R-BTA-186778", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186778" } ] }, { "id": "R-BTA-204873", "name": "Interaction of Tie2 and Shp2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q06807-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-204873", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204873" } ] }, { "id": "R-BTA-205234", "name": "Indirect recruitment of GAB2 to p-KIT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-205234", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-205234" } ] }, { "id": "R-BTA-205238", "name": "SHP2 interacts with p-KIT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-205238", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-205238" } ] }, { "id": "R-BTA-210294", "name": "Interaction of PECAM-1 and SHP-2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1" ], "evidence": [ { "id": "R-BTA-210294", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210294" } ] }, { "id": "R-BTA-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "A0A3Q1LUE0-1", "F1N758-1", "A0AAA9SBR4-1", "F1MN51-1", "Q3ZCC3-1", "Z4YHD9-1", "F1MX49-1", "F1MYM3-1", "F1MRU0-1", "Q1RMT8-1", "Q2LGB3-1", "E1BE66-1", "F1N339-1", "A0A3Q1MHB0-1", "P43481-1", "A0JNB0-1", "E1BIM8-1", "F1N759-1", "F1MNW2-1", "A0A3Q1LT44-1", "F1N6J0-1", "A0AAA9TAT1-1", "Q9TU25-1" ], "evidence": [ { "id": "R-BTA-2316434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2316434" } ] }, { "id": "R-BTA-388829", "name": "SHP2 phosphatase binds CTLA-4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0JNB0-1", "E1BIM8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-388829", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-388829" } ] }, { "id": "R-BTA-389758", "name": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VBZ0-1", "F1N339-1", "F6RY99-1" ], "evidence": [ { "id": "R-BTA-389758", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389758" } ] }, { "id": "R-BTA-389759", "name": "Interaction of SHP-1 or SHP-2 with phospho PD-1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VBZ0-1", "F1N339-1", "F6RY99-1" ], "evidence": [ { "id": "R-BTA-389759", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389759" } ] }, { "id": "R-BTA-453200", "name": "SYK autophosphorylates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F6RY99-1", "A0A3Q1MHG9-1", "A0JNB0-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-453200", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-453200" } ] }, { "id": "R-BTA-5654584", "name": "Activated FGFR1:p-FRS bind to PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654584", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654584" } ] }, { "id": "R-BTA-5654587", "name": "Activated FGFR1:p-FRS phosphorylates PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654587", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654587" } ] }, { "id": "R-BTA-5654594", "name": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654594", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654594" } ] }, { "id": "R-BTA-5654596", "name": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654596", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654596" } ] }, { "id": "R-BTA-5654607", "name": "Activated FGFR2 phosphorylates PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654607", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654607" } ] }, { "id": "R-BTA-5654608", "name": "Activated FGFR2:p-FRS bind to PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654608", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654608" } ] }, { "id": "R-BTA-5654620", "name": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654620", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654620" } ] }, { "id": "R-BTA-5654622", "name": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654622", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654622" } ] }, { "id": "R-BTA-5654631", "name": "Activated FGFR3 phosphorylates PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654631", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654631" } ] }, { "id": "R-BTA-5654633", "name": "Activated FGFR3:p-FRS bind to PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654633", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654633" } ] }, { "id": "R-BTA-5654641", "name": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654641", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654641" } ] }, { "id": "R-BTA-5654643", "name": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654643", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654643" } ] }, { "id": "R-BTA-5654655", "name": "Activated FGFR4 phosphorylates PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654655", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654655" } ] }, { "id": "R-BTA-5654658", "name": "Activated FGFR4:p-FRS bind to PPTN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654658", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654658" } ] }, { "id": "R-BTA-5654667", "name": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654667", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654667" } ] }, { "id": "R-BTA-5654669", "name": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654669", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654669" } ] }, { "id": "R-BTA-5654672", "name": "CBL ubiquitinates FRS2 and FGFR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654672", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654672" } ] }, { "id": "R-BTA-5654673", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654673", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654673" } ] }, { "id": "R-BTA-5654677", "name": "CBL ubiquitinates FRS2 and FGFR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654677", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654677" } ] }, { "id": "R-BTA-5654679", "name": "CBL ubiquitinates FRS2 and FGFR3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654679", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654679" } ] }, { "id": "R-BTA-5654684", "name": "CBL ubiquitinates FRS2 and FGFR4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654684", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654684" } ] }, { "id": "R-BTA-5654692", "name": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "A0A3Q1LUE0-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654692", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654692" } ] }, { "id": "R-BTA-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654697", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654697" } ] }, { "id": "R-BTA-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654709", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654709" } ] }, { "id": "R-BTA-5654714", "name": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654714", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654714" } ] }, { "id": "R-BTA-5654729", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-5654729", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654729" } ] }, { "id": "R-BTA-5654730", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-5654730", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654730" } ] }, { "id": "R-BTA-5654734", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S497-1", "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-5654734", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654734" } ] }, { "id": "R-BTA-5684169", "name": "G6B binds PTPN6,PTPN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F6RY99-1" ], "evidence": [ { "id": "R-BTA-5684169", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684169" } ] }, { "id": "R-BTA-5684801", "name": "p-Y7-CLEC1B dimer:PDPN binds SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F6RY99-1", "A0A3Q1MHG9-1" ], "evidence": [ { "id": "R-BTA-5684801", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684801" } ] }, { "id": "R-BTA-8855508", "name": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1", "F1MS00-1" ], "evidence": [ { "id": "R-BTA-8855508", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8855508" } ] }, { "id": "R-BTA-8865994", "name": "GAB1 binds PTPN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Z4YHD9-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-8865994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8865994" } ] }, { "id": "R-BTA-8937744", "name": "PTPN11 binds p-7Y-RUNX1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N339-1" ], "evidence": [ { "id": "R-BTA-8937744", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937744" } ] }, { "id": "R-BTA-8937767", "name": "PTPN11 dephosphorylates RUNX1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-BTA-8937745", "R-BTA-8865295" ], "enzyme_list": [ "F1N339-1" ], "evidence": [ { "id": "R-BTA-8937767", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937767" } ] }, { "id": "R-BTA-8941613", "name": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LMP2-1", "F1MN51-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-8941613", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941613" } ] }, { "id": "R-BTA-8941618", "name": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LMP2-1", "F1N339-1", "F1MNW2-1" ], "evidence": [ { "id": "R-BTA-8941618", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941618" } ] }, { "id": "R-BTA-8941623", "name": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LUE0-1", "A0A3Q1LMP2-1", "F1N339-1" ], "evidence": [ { "id": "R-BTA-8941623", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941623" } ] }, { "id": "R-BTA-8941628", "name": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LMP2-1", "F1N339-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-8941628", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941628" } ] }, { "id": "R-BTA-8987014", "name": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-8987014", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8987014" } ] }, { "id": "R-BTA-8987070", "name": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-8987070", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8987070" } ] }, { "id": "R-BTA-8987132", "name": "IL22:pY251,pY301IL22RA1:pJAK1:PTPN11:IL10RB:pTYK2 binds PTPN11", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-8987132", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8987132" } ] }, { "id": "R-BTA-8987236", "name": "p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-8987236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8987236" } ] }, { "id": "R-BTA-909738", "name": "SHP1 and SHP2 bind the common beta chain", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SXH6-1", "F1N339-1", "F6RY99-1" ], "evidence": [ { "id": "R-BTA-909738", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-909738" } ] }, { "id": "R-BTA-914036", "name": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SXH6-1", "F1N339-1", "F6RY99-1" ], "evidence": [ { "id": "R-BTA-914036", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-914036" } ] }, { "id": "R-BTA-9674816", "name": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [ "R-BTA-9674821" ], "output_participant_list": [ "R-BTA-9647915" ], "enzyme_list": [ "A0AAA9SXH6-1", "A0A3Q1LMP2-1", "F1MCX4-1", "F1MWN2-1", "F1N339-1", "A0A3Q1MHG9-1", "A0ABI0P1V8-1", "F1N261-1" ], "evidence": [ { "id": "R-BTA-9674816", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674816" } ] }, { "id": "R-BTA-997309", "name": "Dephosphorylation of STAT1 by SHP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCX4-1", "F1N339-1", "A0ABI0P1V8-1" ], "evidence": [ { "id": "R-BTA-997309", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997309" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-180494", "participant_name": "phospho-PAG1 [plasma membrane]", "crossref": [ { "id": "F1MQC1", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000014026", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000065216", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000067689", "database": "ENSEMBL", "url": "" }, { "id": "XP_024857630.1", "database": "RefSeq", "url": "" }, { "id": "XP_059730436.1", "database": "RefSeq", "url": "" }, { "id": "XP_059730437.1", "database": "RefSeq", "url": "" }, { "id": "XP_059730438.1", "database": "RefSeq", "url": "" }, { "id": "XP_024857629.1", "database": "RefSeq", "url": "" }, { "id": "32553", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-180499", "participant_name": "CSK [plasma membrane]", "crossref": [ { "id": "Q0VBZ0", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000028559", "database": "ENSEMBL", "url": "" }, { "id": "27761", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000028559", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000021424", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-180500", "participant_name": "PAG1 [plasma membrane]", "crossref": [ { "id": "XP_059730438.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAT00000067689", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000014026", "database": "ENSEMBL", "url": "" }, { "id": "32553", "database": "VGNC", "url": "" }, { "id": "XP_059730436.1", "database": "RefSeq", "url": "" }, { "id": "F1MQC1", "database": "UniProt", "url": "" }, { "id": "XP_059730437.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000065216", "database": "ENSEMBL", "url": "" }, { "id": "XP_024857629.1", "database": "RefSeq", "url": "" }, { "id": "XP_024857630.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-8865295", "participant_name": "RUNX1 [nucleoplasm]", "crossref": [ { "id": "A0A3Q1MAF6", "database": "UniProt", "url": "" }, { "id": "49959", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8937745", "participant_name": "PTPN11 [nucleoplasm]", "crossref": [ { "id": "33530", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000002048", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000002653", "database": "ENSEMBL", "url": "" }, { "id": "F1N339", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000002653", "database": "ENSEMBL", "url": "" }, { "id": "XP_059732385.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-9647915", "participant_name": "KRAS [plasma membrane]", "crossref": [ { "id": "ENSBTAG00000009778", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000043161", "database": "ENSEMBL", "url": "" }, { "id": "E1BMX0", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000040751", "database": "ENSEMBL", "url": "" }, { "id": "30710", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9674821", "participant_name": "phospho-KRAS [plasma membrane]", "crossref": [ { "id": "E1BMX0", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000009778", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000040751", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000043161", "database": "ENSEMBL", "url": "" }, { "id": "30710", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1LT44", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] } ] }, { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LUE0", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MHB0", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] } ] }, { "uniprot_ac": "A0A3Q1MHG9", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S497", "gene_name": "CBL", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S497", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S497" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S497", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S497" } ] } ] }, { "uniprot_ac": "A0AAA9S7G8", "gene_name": "TRAF3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S7G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S7G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G8" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SBR4", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9SXH6", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAT1", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A0ABI0P1V8", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] } ] }, { "uniprot_ac": "A0JNB0", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BE66", "gene_name": "PIK3CD", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIM8", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MCX4", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MN51", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] } ] }, { "uniprot_ac": "F1MNW2", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQ36", "gene_name": "IKBKE", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ36" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "F1MQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ36" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MRU0", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] } ] }, { "uniprot_ac": "F1MS00", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] } ] }, { "uniprot_ac": "F1MTL5", "gene_name": "PIK3C3", "activity": [ { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "F1MTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "F1MTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MWN2", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] } ] }, { "uniprot_ac": "F1MX49", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1N261", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6J0", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F1N758", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] } ] }, { "uniprot_ac": "F1N759", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P43481", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "Q06807", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q0VBZ0", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q3ZCC3", "gene_name": "TRAF6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3ZCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3ZCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC3" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] }, { "uniprot_ac": "Z4YHD9", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N339-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 592, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N339-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N339" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 101, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 435, "end_pos": 511, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" }, { "id": "PS50055", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50055" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 246, "end_pos": 520, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 565 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 318, "end_pos": 320 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1E7-1", "uniprot_ac": "F1N1E7", "uniprot_id": "F1N1E7_BOVIN", "mass": { "chemical_mass": 86887.0, "monoisotopic_mass": 86887.0 }, "refseq": { "ac": "NP_001180136", "name": "protein PAT1 homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180136" }, "gene_names": [ { "name": "PATL1", "type": "recommended", "evidence": [ { "id": "F1N1E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ] }, { "name": "PATL1", "type": "synonym", "evidence": [ { "id": "NP_001180136", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180136" } ] } ], "protein_names": [ { "name": "Protein PAT1 homolog 1", "type": "recommended", "evidence": [ { "id": "F1N1E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E7/entry#names_and_taxonomy" } ] }, { "name": "PAT1-like protein 1", "type": "synonym", "evidence": [ { "id": "F1N1E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E7/entry#names_and_taxonomy" } ] }, { "name": "Protein PAT1 homolog b", "type": "synonym", "evidence": [ { "id": "F1N1E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E7/entry#names_and_taxonomy" } ] }, { "name": "protein PAT1 homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001180136", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180136" } ] }, { "name": "protein associated with topoisomerase II homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001180136", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180136" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PATL1", "url": "https://www.uniprot.org/uniprotkb/F1N1E7", "locus": { "chromosome": "15", "start_pos": 82824636, "end_pos": 82859455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005913", "url": "https://www.ensembl.org/id/ENSBTAG00000005913" } ] } } ], "crossref": [ { "id": "F1N1E7", "url": "https://alphafold.ebi.ac.uk/entry/F1N1E7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005913", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005913", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "537453", "url": "https://www.ncbi.nlm.nih.gov/gene/537453", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537453", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537453", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QAPMFRA", "url": "https://omabrowser.org/oma/group/QAPMFRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMH1", "url": "https://www.orthodb.org/?gene=A0A3Q1LMH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1E7", "url": "https://www.orthodb.org/?gene=F1N1E7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21551:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21551:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09770", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09770", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-430039", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001180136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180136", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1E7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPAAVNEQSGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPVIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRIGQMLPPAPGFRAFFSAPPPTTPPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRNLNGAGDRGSHRSSHQDHIRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEMQGDGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLFIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICCMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPPVTVTSLLQQLMNLPQSAAAPAPSNPHLSAVLQNKFGLSLLLVVLSRGEDLQSSDAASELAQSNPWTEVMFVATRELLRIPQTGLAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR", "length": 771, "header": "tr|F1N1E7-1|F1N1E7_BOVIN Isoform 1 of Protein PAT1 homolog 1 OS=Bos taurus OX=9913 GN=PATL1 PE=3 SV=2 CANONICAL=F1N1E7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH1/entry", "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPAAVNEQSGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPVIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRIGQMLPPAPGFRAFFSAPPPTTPPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRNLNGAGDRGSHRSSHQDHIRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEMQGDGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLFIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICCMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPPVTVTSLLQQLMNLPQSAAAPAPSNPHLSAVLQNKFGLSLLLVVLSRGEDLQSSDAASELAQSNPWTEVMFVATRELLRIPQTGLAKPISIPTNLVSLFSRYVDRQKLNLLETKLQMQIQ", "length": 769, "header": "tr|A0A3Q1LMH1-1|A0A3Q1LMH1_BOVIN Computationally mapped isoform of Protein PAT1 homolog 1 OS=Bos taurus OX=9913 GN=PATL1 PE=3 SV=2 CANONICAL=F1N1E7-1" }, "locus": { "chromosome": "15", "start_pos": 82859294, "end_pos": 82825640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072254.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072254.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061065.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061065.2" } ] } }, { "isoform_ac": "A0AAA9SWH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH3/entry", "sequence": { "sequence": "MPSVQKVIMKLLCRLSLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPAAVNEQSGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPVIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRIGQMLPPAPGFRAFFSAPPPTTPPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRNLNGAGDRGSHRSSHQDHIRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEMQGDGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLFIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICCMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPPVTVTSLLQQLMNLPQSAAAPAPSNPHLSAVLQNKFGLSLLLVVLSRGEDLQSSDAASELAQSNPWTEVMFVATRELLRIPQTGLAKPISIPTNLVSLFSRYVDRQKLNLLETKLQ", "length": 775, "header": "tr|A0AAA9SWH3-1|F1N1E7_BOVIN Computationally mapped isoform of Protein PAT1 homolog 1 OS=Bos taurus OX=9913 GN=PATL1 PE=3 SV=1 CANONICAL=F1N1E7-1" }, "locus": { "chromosome": "15", "start_pos": 82857480, "end_pos": 82833223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107700.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107700.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088575.1" } ] } }, { "isoform_ac": "F1N1E7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1E7/entry", "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPAAVNEQSGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPVIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRIGQMLPPAPGFRAFFSAPPPTTPPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRNLNGAGDRGSHRSSHQDHIRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEMQGDGPKKERTKLITPQVAKLEHTYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLFIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICCMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPPVTVTSLLQQLMNLPQSAAAPAPSNPHLSAVLQNKFGLSLLLVVLSRGEDLQSSDAASELAQSNPWTEVMFVATRELLRIPQTGLAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR", "length": 771, "header": "tr|F1N1E7-1|F1N1E7_BOVIN Isoform 1 of Protein PAT1 homolog 1 OS=Bos taurus OX=9913 GN=PATL1 PE=3 SV=2 CANONICAL=F1N1E7-1" }, "locus": { "chromosome": "15", "start_pos": 82859294, "end_pos": 82832892, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007768.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007768.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007768.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007768.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 325, "start_aa": "Thr", "end_pos": 325, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr325", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:537453", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537453", "resource": "KEGG Pathway" }, { "id": "R-BTA-430039", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "resource": "Reactome", "description": "mRNA decay by 5' to 3' exoribonuclease" } ], "orthologs": [ { "uniprot_canonical_ac": "B5DF93-1", "protein_name": "Protein PAT1 homolog 1", "gene_name": "Patl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAADEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAVMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPPATPPPQQHPPGPGPHLQNLRPQAPMFRPDTTHLHPQHRRLLHQRQLQSRNQHRNLNGTGDRGGHRVSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKSSAAEEMQGDGPKKERTKLITPQVARLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALTDERKHKIWSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMATARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSATAPAPSNSHLTAVLQNKFGLSLLLILLSRGEDLHSSDPTVESTQNNQWTEVMFMATQELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGMR", "length": 770 }, "evidence": [ { "id": "F1N1E7", "url": "https://omabrowser.org/oma/group/F1N1E7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RI83-1", "protein_name": "Protein PAT1 homolog 1", "gene_name": "PATL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPAAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLGQEMPTVSVLEYALPQRPPQGPEDDRDVSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPIPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPPATPPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRNQHRSLNGAGDRGSHRSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEVQGDGPKKERTKLITPQVAKLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEDRPALMDERKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSAAAPAPASPHLTAVLQNKFGLSLLLVILSRGEDLQSSDPASESTQNSQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR", "length": 771 }, "evidence": [ { "id": "F1N1E7", "url": "https://omabrowser.org/oma/group/F1N1E7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TC46-1", "protein_name": "Protein PAT1 homolog 1", "gene_name": "Patl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAADEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPLQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERISPNQLCSVPNSSLLGHPFPPNVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPSFRAFFSAPPPATPPPQQHPPGPGPHLQNLRPQAPMFRADTTHLHPQHRRLLHQRQLQSRNQHRNLNGTGDRGGHQSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHAYQPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMATARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSASAPAPSNSHLTAVLQNKFGLSLLLILLSRGEDLQSSDPAIESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR", "length": 770 }, "evidence": [ { "id": "F1N1E7", "url": "https://omabrowser.org/oma/group/F1N1E7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86TB9-1", "protein_name": "Protein PAT1 homolog 1", "gene_name": "PATL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFTQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPSATPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRSQHRNLNGAGDRGSHRSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVSITSLLRQLMNLPQSAATPALSNPHLTAVLQNKFGLSLLLILLSRGEDLQSSDPATESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR", "length": 770 }, "evidence": [ { "id": "F1N1E7", "url": "https://omabrowser.org/oma/group/F1N1E7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VEN9-1", "protein_name": "Protein associated with topo II related - 1, isoform A", "gene_name": "Patr-1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDDSFFGFDTNLPDEDGGDGRIVEAEYDALNDETFGSAINGDWEEAHETMVRLGGNGERVRKRPAESSGNTDFADQGNGAFLRHANPLSSAPSSSGSTPAPLNAPFRQSRHIGDSDLELNISSMKLDDMDLSSFTTDSEAGGLSNRIKLDSGVWGSQPFPNNQHLFREPMRSAFKPQQQQHQQHQPQQMKPPQEANANFALNPQPFPKITTLEDIERNMIIQQAIPKQQQQSQQQAERKMFDDFSLGNRQQVPTPTMLQQQMLQQQHHQKQQSQQQPPQQAQHKVPPGFLGTPHTSPPRPNLGFPGPELLPTPSSQQQLNGIGGNRVPPGFIYPQGLPGNIPQLPQHPLMQQHMPHNFPLPGGNQRPLPNPQALPTALNNFAMHPSFNAMRAAGIHPGAFMQPPHPHQMLPPRMPPHPLQAATSLLGQQPPNSMYNMFNMRLVQEIQQNHPLLQQAAVVRQMQQSRAGSVASDRQRSQAQQQQQGRRPDGTGNYPLEEYDEYANLMSTRDKHWLIGIQLSQLNTDTPYIDDYYYTVFRERKAQQNGQMRNSQAHKDNQLNHPLTQPRGHAQLILVQLGNKNGTRNGHGRERRNSENTNSTSGNTNNGSGGNNNNLTGYIFSPLKFENSLGKLQYGSVTAPRKIIDADIMSGESNAAAEANATSSSKSSTPLPTSASHDVNPSSMRKSRHILLLIETLYRYLLKLEDLESPEVMATIELKKKKEAERIAALEQLEMANKTPEERAAEAANPQTMNPQLKNKFNYEVETKAALVNKLKAGLAFDKVIAMMNVRKGKILIRRIMPFIADQSIRWVVWSGVFCSLQTVVKKDKDDVEGVLYALYPEFKKHVNKATFELLVSISSAITLNDKKLAGIFCSRFGILSLVALILRAEEIYVSRTDATLSEENRQKWREFLAQVASCLNRTIQNQTISAAIESDAIQPLMDHFERFKDLKLDALLALITEARHQID", "length": 968 }, "evidence": [ { "id": "F1N1E7", "url": "https://omabrowser.org/oma/group/F1N1E7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "id": "GO:0000290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" }, { "name": "P-body assembly", "id": "GO:0033962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033962", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" }, { "name": "CCR4-NOT complex", "id": "GO:0030014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030014", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" }, { "name": "poly(G) binding", "id": "GO:0034046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034046", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N1E7", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E7" }, { "id": "PF09770", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09770" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "mRNA decay factor PAT1", "eco_id": "ECO_0000259", "start_pos": 475, "end_pos": 717, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 325 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 242, "end_pos": 244 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QNF3-1", "uniprot_ac": "F6QNF3", "uniprot_id": "F6QNF3_BOVIN", "mass": { "chemical_mass": 71037.0, "monoisotopic_mass": 71037.0 }, "refseq": {}, "gene_names": [ { "name": "CTPS1", "type": "recommended", "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ] } ], "protein_names": [ { "name": "CTP synthase", "type": "recommended", "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3/entry#names_and_taxonomy" } ] }, { "name": "6.3.4.2", "type": "synonym", "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3/entry#names_and_taxonomy" } ] }, { "name": "UTP--ammonia ligase", "type": "synonym", "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX55#function" }, { "database": "UniProtKB", "id": "RU810713", "url": "https://www.uniprot.org/uniprotkb/RU810713#function" }, { "database": "UniProtKB", "id": "A0AAA9SYC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC2#function" }, { "database": "UniProtKB", "id": "A0AAA9TSW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW3#function" }, { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3#function" }, { "database": "UniProtKB", "id": "A0A3Q1LQB4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQB4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTPS1", "url": "https://www.uniprot.org/uniprotkb/F6QNF3", "locus": { "chromosome": "3", "start_pos": 105201098, "end_pos": 105256601, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001626", "url": "https://www.ensembl.org/id/ENSBTAG00000001626" } ] } } ], "crossref": [ { "id": "F6QNF3", "url": "https://alphafold.ebi.ac.uk/entry/F6QNF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01746", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01746", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03113", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03113", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506131", "url": "https://www.ncbi.nlm.nih.gov/gene/506131", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11550", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11550", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11550:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11550:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00117", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00117", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06418", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06418", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "26426", "url": "https://www.rhea-db.org/rhea/26426", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "57416", "url": "https://www.rhea-db.org/rhea/57416", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQB4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQB4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QNF3-1", "url": "https://www.uniprot.org/uniprotkb/F6QNF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQNSYVPKVIIPAAAAAKSLQLCPTLCDPIDGRPLGSSVPVIPQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPNTNHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDPDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD", "length": 633, "header": "tr|F6QNF3-1|F6QNF3_BOVIN Isoform 1 of CTP synthase OS=Bos taurus OX=9913 GN=CTPS1 PE=3 SV=1 CANONICAL=F6QNF3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQB4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQB4/entry", "sequence": { "sequence": "MSPCAETSKETSQSMSTSKMKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPNTNHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDPDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD", "length": 610, "header": "tr|A0A3Q1LQB4-1|A0A3Q1LQB4_BOVIN Computationally mapped isoform of CTP synthase OS=Bos taurus OX=9913 GN=CTPS1 PE=3 SV=1 CANONICAL=F6QNF3-1" }, "locus": { "chromosome": "3", "start_pos": 105256570, "end_pos": 105203279, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068403.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068403.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057142.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057142.2" } ] } }, { "isoform_ac": "A0AAA9SX55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX55/entry", "sequence": { "sequence": "MSTSKMKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPNTNHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDPDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD", "length": 596, "header": "tr|A0AAA9SX55-1|F6QNF3_BOVIN Computationally mapped isoform of CTP synthase OS=Bos taurus OX=9913 GN=CTPS1 PE=3 SV=1 CANONICAL=F6QNF3-1" }, "locus": { "chromosome": "3", "start_pos": 105231609, "end_pos": 105203279, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096587.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096587.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088809.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088809.1" } ] } }, { "isoform_ac": "A0AAA9SYC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC2/entry", "sequence": { "sequence": "MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQGRPPGSRNDKPAVALTRSPMAEPSLEGGGDHTV", "length": 450, "header": "tr|A0AAA9SYC2-1|F6QNF3_BOVIN Computationally mapped isoform of CTP synthase OS=Bos taurus OX=9913 GN=CTPS1 PE=3 SV=1 CANONICAL=F6QNF3-1" }, "locus": { "chromosome": "3", "start_pos": 105228910, "end_pos": 105208312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107882.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107882.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089259.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089259.1" } ] } }, { "isoform_ac": "A0AAA9TSW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSW3/entry", "sequence": { "sequence": "MRRFSARFNRLCTVSPYDIPGRDCWSTSKMKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPNTNHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDPDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD", "length": 620, "header": "tr|A0AAA9TSW3-1|F6QNF3_BOVIN Computationally mapped isoform of CTP synthase OS=Bos taurus OX=9913 GN=CTPS1 PE=3 SV=1 CANONICAL=F6QNF3-1" }, "locus": { "chromosome": "3", "start_pos": 105231638, "end_pos": 105203279, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093288.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093288.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100149.1" } ] } }, { "isoform_ac": "F6QNF3-1", "url": "https://www.uniprot.org/uniprotkb/F6QNF3/entry", "sequence": { "sequence": "MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQNSYVPKVIIPAAAAAKSLQLCPTLCDPIDGRPLGSSVPVIPQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEDPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAISWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPNTNHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDPDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD", "length": 633, "header": "tr|F6QNF3-1|F6QNF3_BOVIN Isoform 1 of CTP synthase OS=Bos taurus OX=9913 GN=CTPS1 PE=3 SV=1 CANONICAL=F6QNF3-1" }, "locus": { "chromosome": "3", "start_pos": 105228910, "end_pos": 105203279, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002131.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002131.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002131.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002131.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "CTP synthase activity", "id": "GO:0003883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003883", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "histone H1N76/N77 asparagine deamidase activity", "id": "GO:0160264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160264", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "'de novo' CTP biosynthetic process", "id": "GO:0044210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044210", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "negative regulation of chromosome condensation", "id": "GO:1902340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902340", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "B cell proliferation", "id": "GO:0042100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042100", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "T cell proliferation", "id": "GO:0042098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042098", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "DNA repair-dependent chromatin remodeling", "id": "GO:0140861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140861", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" }, { "name": "cytoophidium", "id": "GO:0097268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097268", "evidence": [ { "database": "UniProtKB", "id": "F6QNF3", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "26426", "name": "", "equation": "UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6QNF3-1", "Q1RMS2-1" ], "evidence": [ { "id": "26426", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26426" } ] }, { "id": "57416", "name": "", "equation": "L-asparaginyl-[protein] + H2O = L-aspartyl-[protein] + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6QNF3-1" ], "evidence": [ { "id": "57416", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/57416" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F6QNF3", "gene_name": "CTPS1", "activity": [ { "ec_number": "6.3.4.2", "activity": "UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+).", "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ] }, { "ec_number": "6.3.4.2", "activity": "", "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" } ] } ] }, { "uniprot_ac": "Q1RMS2", "gene_name": "CTPS2", "activity": [ { "ec_number": "6.3.4.2", "activity": "UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+).", "evidence": [ { "id": "Q1RMS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS2" } ] }, { "ec_number": "6.3.4.2", "activity": "", "evidence": [ { "id": "Q1RMS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMS2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" }, { "id": "PF06418", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06418" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTP synthase N-terminal", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 240, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6QNF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNF3" }, { "id": "PF00117", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glutamine amidotransferase", "eco_id": "ECO_0000259", "start_pos": 353, "end_pos": 580, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.4.2", "ec_name": "UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+).", "evidence": [ { "id": "6.3.4.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2" }, { "id": "6.3.4.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 462, "end_pos": 464 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q3R4-1", "uniprot_ac": "F6Q3R4", "uniprot_id": "F6Q3R4_BOVIN", "mass": { "chemical_mass": 46398.0, "monoisotopic_mass": 46398.0 }, "refseq": { "ac": "XP_015326513", "name": "queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326513" }, "gene_names": [ { "name": "QTRT2", "type": "recommended", "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ] }, { "name": "QTRT2", "type": "synonym", "evidence": [ { "id": "XP_015326513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326513" } ] }, { "name": "QTRTD1", "type": "synonym", "evidence": [ { "id": "XP_015326513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326513" } ] } ], "protein_names": [ { "name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "type": "recommended", "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4/entry#names_and_taxonomy" } ] }, { "name": "Queuine tRNA-ribosyltransferase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4/entry#names_and_taxonomy" } ] }, { "name": "queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015326513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326513" } ] } ], "function": [ { "annotation": "Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU6#function" }, { "database": "HAMAP", "id": "MF_03043", "url": "https://hamap.expasy.org/signature/MF_03043" }, { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "QTRT2", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4", "locus": { "chromosome": "1", "start_pos": 58795781, "end_pos": 58741744, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004977", "url": "https://www.ensembl.org/id/ENSBTAG00000004977" } ] } } ], "crossref": [ { "id": "F6Q3R4", "url": "https://alphafold.ebi.ac.uk/entry/F6Q3R4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004977", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004977", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508374", "url": "https://www.ncbi.nlm.nih.gov/gene/508374", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028592", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028592", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MAGSRMK", "url": "https://omabrowser.org/oma/group/MAGSRMK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6Q3R4", "url": "https://www.orthodb.org/?gene=F6Q3R4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46064:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46064:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01702", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01702", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015326513", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326513", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SYU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q3R4-1", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLNLTKVVNGCRLGKIKNLGKTGDCTMDIPGCLLYTKAGSAPHLTHHTLHKIHGVPAMAQLTLSSLAEHYEVLAEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWGVGGRVEMTASKFMAIQQALQPDWFQCISDGEATCNEATSIKRARKSVDRSLLFLDNCLKLQEESEVLQKSSIIGVIEGGDVTEERLRSARETAKRPVGGFLLDGFQGNPATLETRLHLLSSVTAELPEDKPRLICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKYVDQTKKSKTTSCNQEMTSFEINLKEKKYQEDFSPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHSIREALKSDRLAQLKDLICRQAS", "length": 415, "header": "tr|F6Q3R4-1|F6Q3R4_BOVIN Isoform 1 of Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Bos taurus OX=9913 GN=QTRT2 PE=3 SV=1 CANONICAL=F6Q3R4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU6/entry", "sequence": { "sequence": "MKLNLTKVVNGCRLGKIKNLGKTGDCTMDIPGCLLYTKAGSAPHLTHHTLHKIHGVPAMAQLTLSSLAEHYEVLAEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWGVGGRVEMTASKFMAIQQALQPDWFQCISDGEATCNEATSIKRARKSVDRSLLFLDNCLKLQEESEVLQKSSIIGVIEGGDVTEERLRSARETAKRPVGGFLLDGFQGNPATLETRLHLLSSVTAELPEDKPRLICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKYVDQTKKSKTTSCNQEMTSFEINLKEKKFGNSVLQKESDSSCSHISECIFQLSLQTFITTSLADMKKHWTPWDLAGVALHSQMAGQNLILHTPDNASFLILQSLLRSHYFSFICPWSLLRPWICCR", "length": 437, "header": "tr|A0AAA9SYU6-1|F6Q3R4_BOVIN Computationally mapped isoform of Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Bos taurus OX=9913 GN=QTRT2 PE=3 SV=1 CANONICAL=F6Q3R4-1" }, "locus": { "chromosome": "1", "start_pos": 58795781, "end_pos": 58741766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124682.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124682.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089449.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089449.1" } ] } }, { "isoform_ac": "F6Q3R4-1", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4/entry", "sequence": { "sequence": "MKLNLTKVVNGCRLGKIKNLGKTGDCTMDIPGCLLYTKAGSAPHLTHHTLHKIHGVPAMAQLTLSSLAEHYEVLAEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWGVGGRVEMTASKFMAIQQALQPDWFQCISDGEATCNEATSIKRARKSVDRSLLFLDNCLKLQEESEVLQKSSIIGVIEGGDVTEERLRSARETAKRPVGGFLLDGFQGNPATLETRLHLLSSVTAELPEDKPRLICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKYVDQTKKSKTTSCNQEMTSFEINLKEKKYQEDFSPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHSIREALKSDRLAQLKDLICRQAS", "length": 415, "header": "tr|F6Q3R4-1|F6Q3R4_BOVIN Isoform 1 of Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Bos taurus OX=9913 GN=QTRT2 PE=3 SV=1 CANONICAL=F6Q3R4-1" }, "locus": { "chromosome": "1", "start_pos": 58760105, "end_pos": 58741766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054516.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054516.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048481.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048481.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SX99-1", "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "QTRT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLNKIHGVPAMAQLTLSSLAEHHEVLAEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWGVGGRVEMTTSKFMAIQQALQPDWFQCLSDGEATCDEATSIKRARKSVDRSLLFLDNCLKLQEESEVLQKSTIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPATLETRLHLLSSVTAELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKCVDQTKKIKTTSCNQEMTSFEINLKEKKYQEDFDPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHSIREALKSDHLAQLKELIHRQAS", "length": 415 }, "evidence": [ { "id": "F6Q3R4", "url": "https://omabrowser.org/oma/group/F6Q3R4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XXC1-1", "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "QTRT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRVKLCGAAGGRLGTLAGLGRSGAAALALPGCLLYTRTGTAPHLTLDTLREVSGVPPVAQLTLPTMAELHDVLAEYKEGAAKFIGMPDTVLYCSLQDPVAPCPSGYNTNKTVSLWSSSGRMEMTASKFMDIQRAIQPDWFQCIADGDTISGEVTRKRAKKSVDRSLSFLDACLQLLEKTPELQGSVMFGTIEGGDVLEERLRSARETAKRPVGGFLLDGFQGRAMAKETKMNLISSVTAELPEDKPRIIHGVGKPDEVLECIERGVDIFESFFPFQVTERGCALVFGYDYHSDPKAEAALKQNGAQDLEKNSPEEDQEEEVVKADPEMTPFEIFLKEKRYHDDFRPLLEGCTCYCCQRHTRAYLHHLLVSSELLAGVLLMMHNFQHYFSFFSAIRDALRDDKLDQLKKLIFRQALQGPENAKIDQ", "length": 425 }, "evidence": [ { "id": "F6Q3R4", "url": "https://omabrowser.org/oma/group/F6Q3R4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B8ZXI1-1", "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "Qtrt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLSLIKVVNGCRLGKIQNLGKAGDCTVDIPGCLLYTRTGSAPHLTHQTLRNIHGVPGIAQLTLSSLAEHHEVLAEYKKGVGSFIGMPESLFYCSLHDPVTPGPAGYVTSKSVSVWGFGGRVEMTVSKFMAIQEALQPDWFQCLSDGEASCAETTSIKRARKSVDRSLLFLDSCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGDPAVTETRLHLLSSVTAELPEDKPRLICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFTFDCQLNPEETLLQQNGIQEKIKGLDQAKKIEATGCNQEMTSFEINLKEKKYQEDFDPLVRGCSCYCCKNHTRAYIHHLLMTNELLAGVLLMMHNFEHYFGFFCSIREALKNDTLAQLKELICRQMF", "length": 415 }, "evidence": [ { "id": "F6Q3R4", "url": "https://omabrowser.org/oma/group/F6Q3R4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H974-1", "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "QTRT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMAQLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAGRVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVTAELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS", "length": 415 }, "evidence": [ { "id": "F6Q3R4", "url": "https://omabrowser.org/oma/group/F6Q3R4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "tRNA-guanosine(34) queuine transglycosylase activity", "id": "GO:0008479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008479", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "enzyme-substrate adaptor activity", "id": "GO:0140767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140767", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasmic side of mitochondrial outer membrane", "id": "GO:0032473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032473", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "tRNA-guanine transglycosylase complex", "id": "GO:0120507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120507", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA wobble guanine modification", "id": "GO:0002099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002099", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" }, { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "F6Q3R4", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6Q3R4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 415, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6Q3R4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6Q3R4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" }, { "id": "PF01702", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01702" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "tRNA-guanine(15) transglycosylase-like", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 413, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" }, { "id": "MF_03043", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03043" } ], "binding_site_uniprot": 351, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 351, "end_pos": 351, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" }, { "id": "MF_03043", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03043" } ], "binding_site_uniprot": 353, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 353, "end_pos": 353, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" }, { "id": "MF_03043", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03043" } ], "binding_site_uniprot": 356, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 356, "end_pos": 356, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6Q3R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q3R4" }, { "id": "MF_03043", "database": "HAMAP", "url": "https://hamap.expasy.org/signature/MF_03043" } ], "binding_site_uniprot": 382, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 382, "end_pos": 382, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 304, "end_pos": 306 }, { "start_pos": 358, "end_pos": 360 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QH94-1", "uniprot_ac": "F6QH94", "uniprot_id": "F6QH94_BOVIN", "mass": { "chemical_mass": 48141.0, "monoisotopic_mass": 48141.0 }, "refseq": { "ac": "NP_001193274", "name": "protein disulfide-isomerase A6 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193274" }, "gene_names": [ { "name": "PDIA6", "type": "recommended", "evidence": [ { "id": "F6QH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ] }, { "name": "PDIA6", "type": "synonym", "evidence": [ { "id": "NP_001193274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193274" } ] } ], "protein_names": [ { "name": "Protein disulfide-isomerase A6", "type": "recommended", "evidence": [ { "id": "F6QH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QH94/entry#names_and_taxonomy" } ] }, { "name": "5.3.4.1", "type": "synonym", "evidence": [ { "id": "F6QH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QH94/entry#names_and_taxonomy" } ] }, { "name": "protein disulfide isomerase-associated 6", "type": "synonym", "evidence": [ { "id": "NP_001193274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193274" } ] }, { "name": "protein disulfide-isomerase A6 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193274" } ] } ], "function": [ { "annotation": "May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.", "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94#function" }, { "database": "UniProtKB", "id": "ARBA00045396", "url": "https://www.uniprot.org/uniprotkb/ARBA00045396#function" }, { "database": "UniProtKB", "id": "A0AAA9TGA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDIA6", "url": "https://www.uniprot.org/uniprotkb/F6QH94", "locus": { "chromosome": "11", "start_pos": 86882947, "end_pos": 86859610, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001928", "url": "https://www.ensembl.org/id/ENSBTAG00000001928" } ] } } ], "crossref": [ { "id": "F6QH94", "url": "https://alphafold.ebi.ac.uk/entry/F6QH94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001928", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001928", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02983", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02983", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03001", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03001", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613927", "url": "https://www.ncbi.nlm.nih.gov/gene/613927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613927", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613927", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQKLWGW", "url": "https://omabrowser.org/oma/group/KQKLWGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6QH94", "url": "https://www.orthodb.org/?gene=F6QH94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45815", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45815", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45815:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45815:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193274", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QH94-1", "url": "https://www.uniprot.org/uniprotkb/F6QH94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARLVLGLMSCTLFITVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHQSLGGQYGVQGFPTIKIFGSNKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRGSGYSSGKQGRGDSSSKKDVIELTDDNFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDVAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTISTREPWDGKDGELPVEDDIDLSDVELDDLEKDEL", "length": 440, "header": "tr|F6QH94-1|F6QH94_BOVIN Isoform 1 of Protein disulfide-isomerase A6 OS=Bos taurus OX=9913 GN=PDIA6 PE=1 SV=1 CANONICAL=F6QH94-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TGA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA8/entry", "sequence": { "sequence": "VALGLMSCTLFITVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHQSLGGQYGVQGFPTIKIFGSNKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRGSGYSSGKQGRGDSSSKKDVIELTDDNFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDVAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTISTREPWDGKDGELPVEDDIDLSDVELDDLEKDEL", "length": 437, "header": "tr|A0AAA9TGA8-1|F6QH94_BOVIN Computationally mapped isoform of Protein disulfide-isomerase A6 OS=Bos taurus OX=9913 GN=PDIA6 PE=1 SV=1 CANONICAL=F6QH94-1" }, "locus": { "chromosome": "11", "start_pos": 86881999, "end_pos": 86861812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097213.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097213.1" } ] } }, { "isoform_ac": "F6QH94-1", "url": "https://www.uniprot.org/uniprotkb/F6QH94/entry", "sequence": { "sequence": "MARLVLGLMSCTLFITVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHQSLGGQYGVQGFPTIKIFGSNKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRGSGYSSGKQGRGDSSSKKDVIELTDDNFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDVAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTISTREPWDGKDGELPVEDDIDLSDVELDDLEKDEL", "length": 440, "header": "tr|F6QH94-1|F6QH94_BOVIN Isoform 1 of Protein disulfide-isomerase A6 OS=Bos taurus OX=9913 GN=PDIA6 PE=1 SV=1 CANONICAL=F6QH94-1" }, "locus": { "chromosome": "11", "start_pos": 86881999, "end_pos": 86859716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002508.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002508.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002508.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002508.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:613927", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613927", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XGH4-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGVRGTGGLWWGTVSCTLFLAVNGLYSASDDVIELTPTNFNKEVIQSESLWLVEFYAPWCGHCQRLTPEWKKAATALKGVVKVGAVDADKHQSLGGQYGVRGFPTIKIFGANKNKAEDYQGGRTSEAIVDAALSALRSLVKDRLSGRSGGYSSGRQSRESGGGDKKDVIELTDDSFDKNVINSDDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQMLANRYGIRGFPTIKIFQKGEDPVDYDGGRTRSDIIARALDLFSDNAPPPELLEIINEDVLKTTCDAHQLCIISVLPHILDTGASGRNSYLDVMLKMAEKYKKKMWGWLWTEAGAQSDLESSLGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSVGRGSTAPVGGGAFPKIHAVEPWDGKDGELPVEDDIDLSDVDLDDIWDKDEL", "length": 447 }, "evidence": [ { "id": "F6QH94", "url": "https://omabrowser.org/oma/group/F6QH94/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL", "length": 440 }, "evidence": [ { "id": "F6QH94", "url": "https://omabrowser.org/oma/group/F6QH94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q63081-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "Pdia6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARLVLGLVSCTFFLAVSALYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPNITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL", "length": 440 }, "evidence": [ { "id": "F6QH94", "url": "https://omabrowser.org/oma/group/F6QH94/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9MAU6-1", "protein_name": "Protein disulfide-isomerase like 2-2", "gene_name": "PDIL2-2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MERKMYKSTVFPICCLLFALFDRGNALYGSSSPVLQLTPSNFKSKVLNSNGVVLVEFFAPWCGHCQSLTPTWEKVASTLKGIATVAAIDADAHKSVSQDYGVRGFPTIKVFVPGKPPIDYQGARDAKSISQFAIKQIKALLKDRLDGKTSGTKNGGGSSEKKKSEPSASVELNSSNFDELVTESKELWIVEFFAPWCGHCKKLAPEWKKAANNLKGKVKLGHVNCDAEQSIKSRFKVQGFPTILVFGSDKSSPVPYEGARSASAIESFALEQLESNAGPAEVTELTGPDVMEDKCGSAAICFVSFLPDILDSKAEGRNKYLEMLLSVADKFKKDPYGFVWVAAGKQPDLEKRVGVGGYGYPAMVALNAKKGAYAPLKSGFEVKHLKDFVKEAAKGGKGNLPIDGTMEIVKTEAWDGKDGEVVDADEFSLEDLMGNDDEASTESKDDL", "length": 447 }, "evidence": [ { "id": "F6QH94", "url": "https://omabrowser.org/oma/group/F6QH94/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V438-1", "protein_name": "Protein disulfide-isomerase A6 homolog", "gene_name": "CaBP1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRQLASILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRDISYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEEDIDLSDIDLDKDEL", "length": 433 }, "evidence": [ { "id": "F6QH94", "url": "https://omabrowser.org/oma/group/F6QH94/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein disulfide isomerase activity", "id": "GO:0003756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003756", "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ], "pmid": "" }, { "name": "protein-disulfide reductase activity", "id": "GO:0015035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015035", "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "F6QH94", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q10741-1", "O77836-1", "Q95M18-1", "Q1LZE9-1", "F1N076-1", "F1N5H2-1", "G5E5T0-1", "F6QH94-1", "F6Q9Q9-1", "A0A140T851-1" ], "evidence": [ { "id": "R-BTA-8952289", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8952289" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T851", "gene_name": "PROC", "activity": [ { "ec_number": "3.4.21.69", "activity": "Degradation of blood coagulation factors Va and VIIIa.", "evidence": [ { "id": "A0A140T851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T851" } ] }, { "ec_number": "3.4.21.69", "activity": "", "evidence": [ { "id": "A0A140T851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T851" } ] } ] }, { "uniprot_ac": "F1N076", "gene_name": "CP", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] } ] }, { "uniprot_ac": "F1N5H2", "gene_name": "FUCA2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] } ] }, { "uniprot_ac": "F6Q9Q9", "gene_name": "P4HB", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "F6Q9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9Q9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "F6Q9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9Q9" } ] } ] }, { "uniprot_ac": "F6QH94", "gene_name": "PDIA6", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "F6QH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "F6QH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QH94" } ] } ] }, { "uniprot_ac": "G5E5T0", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] } ] }, { "uniprot_ac": "O77836", "gene_name": "MGAT4A", "activity": [ { "ec_number": "2.4.1.145", "activity": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+).", "evidence": [ { "id": "O77836", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77836" } ] }, { "ec_number": "2.4.1.145", "activity": "", "evidence": [ { "id": "O77836", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77836" } ] } ] }, { "uniprot_ac": "Q10741", "gene_name": "ADAM10", "activity": [ { "ec_number": "3.4.24.81", "activity": "Endopeptidase of broad specificity.", "evidence": [ { "id": "Q10741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10741" } ] }, { "ec_number": "3.4.24.81", "activity": "", "evidence": [ { "id": "Q10741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q10741" } ] } ] }, { "uniprot_ac": "Q1LZE9", "gene_name": "PRSS23", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q1LZE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZE9" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QH94-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 440, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QH94-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QH94" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QH94" }, { "id": "PS51352", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51352" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 133, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.3.4.1", "ec_name": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "5.3.4.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.3.4.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5D1-1", "uniprot_ac": "F1N5D1", "uniprot_id": "F1N5D1_BOVIN", "mass": { "chemical_mass": 36614.0, "monoisotopic_mass": 36614.0 }, "refseq": { "ac": "NP_001074377", "name": "carbonic anhydrase 5B, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074377" }, "gene_names": [ { "name": "CA5B", "type": "recommended", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ] }, { "name": "CA5B", "type": "synonym", "evidence": [ { "id": "NP_001074377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074377" } ] } ], "protein_names": [ { "name": "Carbonic anhydrase", "type": "recommended", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.1", "type": "synonym", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1/entry#names_and_taxonomy" } ] }, { "name": "carbonic anhydrase 5B, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001074377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074377" } ] } ], "function": [ { "annotation": "Reversible hydration of carbon dioxide.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TUI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI2#function" }, { "database": "UniProtKB", "id": "RU367011", "url": "https://www.uniprot.org/uniprotkb/RU367011#function" }, { "database": "UniProtKB", "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CA5B", "url": "https://www.uniprot.org/uniprotkb/F1N5D1", "locus": { "chromosome": "X", "start_pos": 127724914, "end_pos": 127752302, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020418", "url": "https://www.ensembl.org/id/ENSBTAG00000020418" } ] } } ], "crossref": [ { "id": "F1N5D1", "url": "https://alphafold.ebi.ac.uk/entry/F1N5D1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020418", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020418", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514494", "url": "https://www.ncbi.nlm.nih.gov/gene/514494", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514494", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514494", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GESNDWG", "url": "https://omabrowser.org/oma/group/GESNDWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N5D1", "url": "https://www.orthodb.org/?gene=F1N5D1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1475029", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001074377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074377", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10748", "url": "https://www.rhea-db.org/rhea/10748", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TUI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5D1-1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVMMSHLRAILQASPYKTLWRRFQIPRSMPARPCSLYTCTYKSRNRVLHPLWEKVDLAPAGERQSPINIRWKDSVYDPGLQPLTISYDPTTCLHVWNNGYSFLVEFEDSADKSVIEGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCYPAELHLVHWNAVKFEHFEDAALEENGLAVIGVFLKLGKHHKELQKLVNILPSIKHKDTLAEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFHHDYVLNIQAKPKPSTSQVTP", "length": 317, "header": "tr|F1N5D1-1|F1N5D1_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5B PE=3 SV=1 CANONICAL=F1N5D1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TUI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI2/entry", "sequence": { "sequence": "MVMMSHLRAILQASPYKTLWRRFQIPRSMPARPCSLYTCTYKSRNRVLHPLWEKVDLAPAGERQSPINIRWKDSVYDPGLQPLTISYDPTTCLHVWNNGYSFLVEFEDSADKSVIEGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCYPAELHLVHWNAVKFEHFEDAALEENGLAVIGVFLKDTLAEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFHHDYVLNIQAKPKPSTSQVTP", "length": 296, "header": "tr|A0AAA9TUI2-1|F1N5D1_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5B PE=3 SV=1 CANONICAL=F1N5D1-1" }, "locus": { "chromosome": "X", "start_pos": 127743377, "end_pos": 127727046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105215.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105215.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102027.1" } ] } }, { "isoform_ac": "F1N5D1-1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1/entry", "sequence": { "sequence": "MVMMSHLRAILQASPYKTLWRRFQIPRSMPARPCSLYTCTYKSRNRVLHPLWEKVDLAPAGERQSPINIRWKDSVYDPGLQPLTISYDPTTCLHVWNNGYSFLVEFEDSADKSVIEGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCYPAELHLVHWNAVKFEHFEDAALEENGLAVIGVFLKLGKHHKELQKLVNILPSIKHKDTLAEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFHHDYVLNIQAKPKPSTSQVTP", "length": 317, "header": "tr|F1N5D1-1|F1N5D1_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5B PE=3 SV=1 CANONICAL=F1N5D1-1" }, "locus": { "chromosome": "X", "start_pos": 127743377, "end_pos": 127727046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027210.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027210.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027210.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027210.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514494", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514494", "resource": "KEGG Pathway" }, { "id": "R-BTA-1475029", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "resource": "Reactome", "description": "Reversible hydration of carbon dioxide" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YA50-1", "protein_name": "Carbonic anhydrase", "gene_name": "CA5A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMNSIKTNGLGRLFKQLKSAWSSPAVPARSCSLATCTPKNRNDALHPLWQSPLTIPGGTRQSPINIQWRDSVYDPVLKPLKISYDPATCLHIWNNGYSFLVEFDDSADRSIIVGGPLENQYRLKQFHFHWGAINEWGSEHTVDSKFYPAELHLVHWNAVVYPTFEEAVMEGDGLAVIGVFLKLGAHHEGLQTLVDALPAIKHKDTVIEFDVFDPSCLLPPCPDYWTYAGSLTTPPLTESVTWIIKKQPIEVDENQLEAFRMLLFTSDGEEEKRMVDNFRPLQPLMNRTVRSSFQIRQLLDIEAQYSDHAQQIRP", "length": 314 }, "evidence": [ { "id": "F1N5D1", "url": "https://omabrowser.org/oma/group/F1N5D1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q66HG6-1", "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "Ca5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVMSHLRVSLQVSSCTLLWRRFRVPRLVPLRSCSLYTCTYRTRNRALPPLWENLDLVPAGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHIWNNGYSFLVEFEDTTDKSVIEGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCYPAELHLVHWNAVKFESFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDTLVKFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNIQVKPEPTASEVSP", "length": 317 }, "evidence": [ { "id": "F1N5D1", "url": "https://omabrowser.org/oma/group/F1N5D1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QZA0-1", "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "Ca5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVMNHLRVILQVSSSTLPWRRCWVPRLVPRRSCSLYTCTYRTRNRALPPLWENLDLVPAGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHIWNNGYSFLVEFEDSTDKSVVEGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCYPAELHLVHWNAVKFESFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDTLVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDRDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNIQVKPKPTASEVTP", "length": 317 }, "evidence": [ { "id": "F1N5D1", "url": "https://omabrowser.org/oma/group/F1N5D1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2D0-1", "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "CA5B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP", "length": 317 }, "evidence": [ { "id": "F1N5D1", "url": "https://omabrowser.org/oma/group/F1N5D1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ], "pmid": "" }, { "name": "carbonate dehydratase activity", "id": "GO:0004089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004089", "evidence": [ { "database": "UniProtKB", "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N5D1", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10748", "name": "", "equation": "hydrogencarbonate + H(+) = CO2 + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "G3MX64-1", "E1BAD9-1", "E1BHA4-1", "F1MBS0-1", "F1MPL2-1", "Q95323-1", "P00921-1", "P18915-1", "Q1LZA1-1", "Q3SZX4-1", "F1N0H3-1", "E1BPA4-1", "A0A0A0MP99-1", "A0A3Q1LYT6-1" ], "evidence": [ { "id": "10748", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10748" } ] }, { "id": "R-BTA-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "E1BAD9-1" ], "evidence": [ { "id": "R-BTA-1475028", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475028" } ] }, { "id": "R-BTA-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "E1BAD9-1" ], "evidence": [ { "id": "R-BTA-1475032", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475032" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0A0MP99", "gene_name": "LOC100847874", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] } ] }, { "uniprot_ac": "A0A3Q1LYT6", "gene_name": "LOC784254", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] } ] }, { "uniprot_ac": "E1BAD9", "gene_name": "CA5A", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] } ] }, { "uniprot_ac": "E1BHA4", "gene_name": "CA7", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] } ] }, { "uniprot_ac": "E1BPA4", "gene_name": "CA9", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] } ] }, { "uniprot_ac": "F1MBS0", "gene_name": "CA6", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] } ] }, { "uniprot_ac": "F1MPL2", "gene_name": "CA12", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1MPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1MPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ] } ] }, { "uniprot_ac": "F1N0H3", "gene_name": "CA2", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1N0H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0H3" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1N0H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0H3" } ] } ] }, { "uniprot_ac": "F1N5D1", "gene_name": "CA5B", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ] } ] }, { "uniprot_ac": "G3MX64", "gene_name": "CA13", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "G3MX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX64" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "G3MX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX64" } ] } ] }, { "uniprot_ac": "P00921", "gene_name": "CA2", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "P00921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00921" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "P00921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00921" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "P00921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00921" } ] } ] }, { "uniprot_ac": "P18915", "gene_name": "CA6", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "P18915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18915" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "P18915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18915" } ] } ] }, { "uniprot_ac": "Q1LZA1", "gene_name": "CA1", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "Q1LZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA1" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "Q1LZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA1" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "Q1LZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA1" } ] } ] }, { "uniprot_ac": "Q3SZX4", "gene_name": "CA3", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "Q3SZX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "Q3SZX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX4" } ] } ] }, { "uniprot_ac": "Q95323", "gene_name": "CA4", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "Q95323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95323" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "Q95323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95323" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5D1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 317, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5D1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5D1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" }, { "id": "PS51144", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51144" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-carbonic anhydrase", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 296, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.1", "ec_name": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "4.2.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1" }, { "id": "4.2.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 289, "end_pos": 291 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4U1-1", "uniprot_ac": "F1N4U1", "uniprot_id": "F1N4U1_BOVIN", "mass": { "chemical_mass": 69576.0, "monoisotopic_mass": 69576.0 }, "refseq": { "ac": "XP_010818639", "name": "sodium-dependent phosphate transporter 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818639" }, "gene_names": [ { "name": "SLC20A2", "type": "recommended", "evidence": [ { "id": "F1N4U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ] }, { "name": "SLC20A2", "type": "synonym", "evidence": [ { "id": "XP_010818639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818639" } ] } ], "protein_names": [ { "name": "Phosphate transporter", "type": "recommended", "evidence": [ { "id": "F1N4U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U1/entry#names_and_taxonomy" } ] }, { "name": "sodium-dependent phosphate transporter 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010818639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818639" } ] } ], "function": [ { "annotation": "Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM53#function" }, { "database": "UniProtKB", "id": "ARBA00045989", "url": "https://www.uniprot.org/uniprotkb/ARBA00045989#function" }, { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC20A2", "url": "https://www.uniprot.org/uniprotkb/F1N4U1", "locus": { "chromosome": "27", "start_pos": 37252190, "end_pos": 37331294, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014861", "url": "https://www.ensembl.org/id/ENSBTAG00000014861" } ] } } ], "crossref": [ { "id": "F1N4U1", "url": "https://alphafold.ebi.ac.uk/entry/F1N4U1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014861", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014861", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518905", "url": "https://www.ncbi.nlm.nih.gov/gene/518905", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MQAFCIA", "url": "https://omabrowser.org/oma/group/MQAFCIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4U1", "url": "https://www.orthodb.org/?gene=F1N4U1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11101:SF83", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101:SF83", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01384", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01384", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-427652", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-427652", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010818639", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818639", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "71259", "url": "https://www.rhea-db.org/rhea/71259", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6DM53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4U1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNNTVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGATIGFSLVAIGTQGVQWMELVKIVASWFISPLLSGFMSGVLFVLIRMFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVMGLVLPMWAIALISFGVALLFALFVWLFVCPWMRRKITGKLQKECALSRASDESLNKIQEVESPVFKELPGAKAHDDSTVPLTGSAADPSGTSESMSGGHHPRAPYGRALSMTHGTTKSPVSNGTFGFDGTARADGHVYHTVHKDSGLYKDLLHRIRDERPADGAPRQLRRNNSYTCYTAAICGLPGLATRRGDTPAPEDSEKLVADAVAYSRRRLRYDSYSSYCNAVAEAEIEAEEGGVEVRLAPPLAEPEPPRDDPADEEKEEKDSPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYEQGAVLQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAIMALLIHGILPFV", "length": 645, "header": "tr|F1N4U1-1|F1N4U1_BOVIN Isoform 1 of Phosphate transporter OS=Bos taurus OX=9913 GN=SLC20A2 PE=3 SV=1 CANONICAL=F1N4U1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DM53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM53/entry", "sequence": { "sequence": "MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNNTVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGATIGFSLVAIGTQGVQWMELVKIVASWFISPLLSGFMSGVLFVLIRMFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVMGLVLPMWAIALISFGVALLFALFVWLFVCPWMRRKITGKLQKECALSRASDESLNKIQEVESPVFKELPGAKAHDDSTVPLTGSAADPSGTSESMSGGHHPRAPYGRALSMTHGTTKSPVSNGTFGFDGTARADGHVYHTVHKDSGLYKDLLHRIRDERPADGAPRQLRRNNSYTCYTAAICGLPGLATRRGDTPAPEDSEKLVADAVAYSRRRLRYDSYSSYCNAVAEAEIEAEEGGVEVRLAPPLAEPEPPRDDPADEEKEEKDSPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYEQGAVLQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKC", "length": 592, "header": "tr|A0AAF6DM53-1|F1N4U1_BOVIN Computationally mapped isoform of Phosphate transporter OS=Bos taurus OX=9913 GN=SLC20A2 PE=3 SV=1 CANONICAL=F1N4U1-1" }, "locus": { "chromosome": "27", "start_pos": 37306374, "end_pos": 37262989, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063501.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063501.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056283.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056283.3" } ] } }, { "isoform_ac": "F1N4U1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1/entry", "sequence": { "sequence": "MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNNTVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGATIGFSLVAIGTQGVQWMELVKIVASWFISPLLSGFMSGVLFVLIRMFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVMGLVLPMWAIALISFGVALLFALFVWLFVCPWMRRKITGKLQKECALSRASDESLNKIQEVESPVFKELPGAKAHDDSTVPLTGSAADPSGTSESMSGGHHPRAPYGRALSMTHGTTKSPVSNGTFGFDGTARADGHVYHTVHKDSGLYKDLLHRIRDERPADGAPRQLRRNNSYTCYTAAICGLPGLATRRGDTPAPEDSEKLVADAVAYSRRRLRYDSYSSYCNAVAEAEIEAEEGGVEVRLAPPLAEPEPPRDDPADEEKEEKDSPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYEQGAVLQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAIMALLIHGILPFV", "length": 645, "header": "tr|F1N4U1-1|F1N4U1_BOVIN Isoform 1 of Phosphate transporter OS=Bos taurus OX=9913 GN=SLC20A2 PE=3 SV=1 CANONICAL=F1N4U1-1" }, "locus": { "chromosome": "27", "start_pos": 37306374, "end_pos": 37253488, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019790.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019790.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019790.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019790.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-427652", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-427652", "resource": "Reactome", "description": "Sodium-coupled phosphate cotransporters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PVB6-1", "protein_name": "Phosphate transporter", "gene_name": "SLC20A2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAMEEYLWMVIVGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASVFETTGSVLLGAKVGETIRKGIIDVNLYNDTVPLLMAGEVSAMVGSAVWQLIASFLKLPISGTHCIVGATIGFSLVAIGTQGVQWMQLVKIVASWFISPLLSGLMSGVLFVLIRFFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISLGVSLVFAVLVWIFVCPWMKRKIESRLKKDAALSRISDESLDKIQDEETSVFKELPGAKASDESSVPLTGSVTEAAGASDTIANGNHPRVPYGRAFSMTHTSVKSPVSNGTFSFDGQVRSDGHVYHTVHKDSGLYKDLLHKMHLDRSTDEKPAQENNYKLLRRNNSYTCYTAAICGMPVHSSFKAADTSTPEDSEKLVGDTVSYSKKRVRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPNRPPEDPVEEDKEEKDTSQVHLLFHFLQILTACFGSFAHGGNDVSNAIGPLVALWLIYEQGAVMQEASTPVWLLFYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVVASNVGLPVSTTHCKVGSVVAVGWIRSKKAVDWRLFRNIFLAWFVTVPVAGLFSAGVMALLMYGILPYV", "length": 652 }, "evidence": [ { "id": "F1N4U1", "url": "https://omabrowser.org/oma/group/F1N4U1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q08357-1", "protein_name": "Sodium-dependent phosphate transporter 2", "gene_name": "SLC20A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV", "length": 652 }, "evidence": [ { "id": "F1N4U1", "url": "https://omabrowser.org/oma/group/F1N4U1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q63488-1", "protein_name": "Sodium-dependent phosphate transporter 2", "gene_name": "Slc20a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPVFKELPGAKASDDSAVPLTSLAGEAAGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFEGHMRNDGHVYHTVHKDSGLYKDLLHKIHVDKGPEEKPAQENNYRLLRRNNSYTCYTAAICGMPVHATFRASDTSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMRLASELTDPDQPHEDPAEDEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFIAWFVTVPVAGLFSAAIMALLMYICGFVSSSR", "length": 656 }, "evidence": [ { "id": "F1N4U1", "url": "https://omabrowser.org/oma/group/F1N4U1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80UP8-1", "protein_name": "Sodium-dependent phosphate transporter 2", "gene_name": "Slc20a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPGFKELPGAKPSDDSAVPLTSLAGEAVGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFEGHMRNDGHVYHTVHKDSGLYKDLLHKIHVDRGSEEKPTQENNYRLLRRNNSYTCYTAAICGMPVHTTFRASDTSSAPEDSEKLVGDSVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMRLASELADPDRPHEDPTEEEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYQQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAIMALLMYICGLFSSSR", "length": 656 }, "evidence": [ { "id": "F1N4U1", "url": "https://omabrowser.org/oma/group/F1N4U1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" }, { "name": "phosphate transmembrane transporter activity", "id": "GO:0005315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005315", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" }, { "name": "virus receptor activity", "id": "GO:0001618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001618", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" }, { "name": "sodium:phosphate symporter activity", "id": "GO:0005436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005436", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" }, { "name": "phosphate ion transport", "id": "GO:0006817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006817", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" }, { "name": "positive regulation of bone mineralization", "id": "GO:0030501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030501", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" }, { "name": "phosphate ion transmembrane transport", "id": "GO:0035435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035435", "evidence": [ { "database": "UniProtKB", "id": "F1N4U1", "url": "https://www.uniprot.org/uniprotkb/F1N4U1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "71259", "name": "", "equation": "2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71259", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71259" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4U1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 645, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4U1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4U1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 560 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 328, "end_pos": 330 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5G3-1", "uniprot_ac": "F1N5G3", "uniprot_id": "F1N5G3_BOVIN", "mass": { "chemical_mass": 31097.0, "monoisotopic_mass": 31097.0 }, "refseq": { "ac": "XP_005218736", "name": "E3 ubiquitin-protein ligase SIAH1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218736" }, "gene_names": [ { "name": "SIAH1", "type": "recommended", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "name": "SIAH1", "type": "synonym", "evidence": [ { "id": "XP_005218736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218736" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase", "type": "recommended", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase SIAH1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218736" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3#function" }, { "database": "UniProtKB", "id": "RU201113", "url": "https://www.uniprot.org/uniprotkb/RU201113#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SIAH1", "url": "https://www.uniprot.org/uniprotkb/F1N5G3", "locus": { "chromosome": "18", "start_pos": 16771820, "end_pos": 16794928, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010868", "url": "https://www.ensembl.org/id/ENSBTAG00000010868" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010868", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010868", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03829", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03829", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534655", "url": "https://www.ncbi.nlm.nih.gov/gene/534655", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534655", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534655", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HSNTGCT", "url": "https://omabrowser.org/oma/group/HSNTGCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N5G3", "url": "https://www.orthodb.org/?gene=F1N5G3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45877:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45877:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21361", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21361", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21362", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21362", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005218736", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218736", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5G3-1", "url": "https://www.uniprot.org/uniprotkb/F1N5G3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRQTATALPTGTSKCAPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC", "length": 282, "header": "tr|F1N5G3-1|F1N5G3_BOVIN Isoform 1 of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=SIAH1 PE=3 SV=3 CANONICAL=F1N5G3-1" }, "isoforms": [ { "isoform_ac": "F1N5G3-1", "url": "https://www.uniprot.org/uniprotkb/F1N5G3/entry", "sequence": { "sequence": "MSRQTATALPTGTSKCAPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC", "length": 282, "header": "tr|F1N5G3-1|F1N5G3_BOVIN Isoform 1 of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=SIAH1 PE=3 SV=3 CANONICAL=F1N5G3-1" }, "locus": { "chromosome": "18", "start_pos": 16773756, "end_pos": 16772911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053788.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053788.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052492.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052492.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534655", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534655", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JJJ4-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "Siah1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEVSSLLCLGAKGLAGSSGAGWPCGLQEPDASILMTWKPPEPLLHSWKGVLLACLPTVRTRTRKRKEMSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC", "length": 349 }, "evidence": [ { "id": "F1N5G3", "url": "https://omabrowser.org/oma/group/F1N5G3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1P2G0-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "SIAH1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRQTATALPTGTSKCTPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC", "length": 282 }, "evidence": [ { "id": "F1N5G3", "url": "https://omabrowser.org/oma/group/F1N5G3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P21461-1", "protein_name": "E3 ubiquitin-protein ligase sina", "gene_name": "sina", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNKINPKRREPTAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSSSSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSKLTCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFADNGNLGINVTISLV", "length": 314 }, "evidence": [ { "id": "F1N5G3", "url": "https://omabrowser.org/oma/group/F1N5G3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P61092-1", "protein_name": "E3 ubiquitin-protein ligase SIAH1A", "gene_name": "Siah1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC", "length": 282 }, "evidence": [ { "id": "F1N5G3", "url": "https://omabrowser.org/oma/group/F1N5G3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IUQ4-1", "protein_name": "E3 ubiquitin-protein ligase SIAH1", "gene_name": "SIAH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC", "length": 282 }, "evidence": [ { "id": "F1N5G3", "url": "https://omabrowser.org/oma/group/F1N5G3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N5G3", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 76, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" }, { "id": "PS51081", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51081" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SIAH-type", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 153, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 276, "end_pos": 278 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2J6-1", "uniprot_ac": "F1N2J6", "uniprot_id": "F1N2J6_BOVIN", "mass": { "chemical_mass": 53868.0, "monoisotopic_mass": 53868.0 }, "refseq": { "ac": "XP_005211706", "name": "myocardial zonula adherens protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211706" }, "gene_names": [ { "name": "MYZAP", "type": "recommended", "evidence": [ { "id": "F1N2J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ] }, { "name": "MYZAP", "type": "synonym", "evidence": [ { "id": "XP_005211706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211706" } ] } ], "protein_names": [ { "name": "Myocardial zonula adherens protein", "type": "synonym", "evidence": [ { "id": "F1N2J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J6/entry#names_and_taxonomy" } ] }, { "name": "myocardial zonula adherens protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005211706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211706" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYZAP", "url": "https://www.uniprot.org/uniprotkb/F1N2J6", "locus": { "chromosome": "10", "start_pos": 52607554, "end_pos": 52741681, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002194", "url": "https://www.ensembl.org/id/ENSBTAG00000002194" } ] } } ], "crossref": [ { "id": "F1N2J6", "url": "https://alphafold.ebi.ac.uk/entry/F1N2J6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002194", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002194", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "104968465", "url": "https://www.ncbi.nlm.nih.gov/gene/104968465", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968465", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968465", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CMGMEKS", "url": "https://omabrowser.org/oma/group/CMGMEKS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDW3", "url": "https://www.orthodb.org/?gene=A0A3Q1MDW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2J6", "url": "https://www.orthodb.org/?gene=F1N2J6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23171:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23171:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005211706", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211706", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDW3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3X0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3X0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N791", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N791", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N791-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N791-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9P8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9P8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2F1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6H8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6H8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6H8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2J6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2J6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPSQTGRTREISMPSRNYTPYTRVLELTTKKTLT", "length": 463, "header": "tr|F1N2J6-1|F1N2J6_BOVIN Isoform 1 of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=2 CANONICAL=F1N2J6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDW3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDW3/entry", "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPRIHLSTLTTWGNQQRK", "length": 447, "header": "tr|A0A3Q1MDW3-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=2 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52719311, "end_pos": 52625159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072323.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072323.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069151.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069151.2" } ] } }, { "isoform_ac": "A0A3Q1N3X0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3X0/entry", "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPRKPGLIPGTGKSPGEGNGYPLYYSCLENPMDRGLLKVPWTAKRSSQSVLKPNR", "length": 484, "header": "tr|A0A3Q1N3X0-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=2 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52719311, "end_pos": 52608643, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078519.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078519.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064324.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064324.2" } ] } }, { "isoform_ac": "A0A3Q1N791-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N791/entry", "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEENNELQSRLDYLIETQSKTEVETREVGVGCDLLPSQTGRTREISMPSRNYTPYTRVLELTTKKTLT", "length": 435, "header": "tr|A0A3Q1N791-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=1 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52719311, "end_pos": 52608558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082796.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082796.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066492.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066492.1" } ] } }, { "isoform_ac": "A0A3Q1N9P8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9P8/entry", "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPSQTGRTREISMPSRNYTPYTRVLELTTKKTLT", "length": 425, "header": "tr|A0A3Q1N9P8-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=1 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52719311, "end_pos": 52608558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082400.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082400.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067888.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067888.1" } ] } }, { "isoform_ac": "A0AAA9S2F1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F1/entry", "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIMSHELFSRFSLRLFGR", "length": 387, "header": "tr|A0AAA9S2F1-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=1 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52719311, "end_pos": 52661203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094720.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094720.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077881.1" } ] } }, { "isoform_ac": "A0AAA9T6H8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6H8/entry", "sequence": { "sequence": "MPGTRQLMCGRALTDTQANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPRYQN", "length": 430, "header": "tr|A0AAA9T6H8-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=1 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52728365, "end_pos": 52624741, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096491.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096491.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094368.1" } ] } }, { "isoform_ac": "A0AAA9U1L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1L3/entry", "sequence": { "sequence": "MPGTRQLMCGRALTDTQANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPSQTGRTREISMPSRNYTPYTRVLELTTKKTLT", "length": 458, "header": "tr|A0AAA9U1L3-1|F1N2J6_BOVIN Computationally mapped isoform of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=1 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52728365, "end_pos": 52608558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111715.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111715.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103120.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103120.1" } ] } }, { "isoform_ac": "F1N2J6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2J6/entry", "sequence": { "sequence": "MLRSTSTVTLLSGSGSGAPSRRANVCRLRLTVPPENPVPEPSEKKVERREQHRDLSNGESTRKLPQGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSQAKQDYLENHIQTQSSALDSFNAMNAALASDSISLQKTLVDVTLENSNIKDQIRNLQQTYTASMDKLREKQRQLDAAQVENKLLKMKVECSQQANAEVMREMTRKLYSQYEEKLQEEQQRHNAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSNKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLIETQSKTEVETREVGVGCDLLPSQTGRTREISMPSRNYTPYTRVLELTTKKTLT", "length": 463, "header": "tr|F1N2J6-1|F1N2J6_BOVIN Isoform 1 of Myocardial zonula adherens protein OS=Bos taurus OX=9913 GN=MYZAP PE=4 SV=2 CANONICAL=F1N2J6-1" }, "locus": { "chromosome": "10", "start_pos": 52719311, "end_pos": 52608558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002839.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002839.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002839.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002839.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104968465", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968465", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RZH1-1", "protein_name": "Myocardial zonula adherens protein", "gene_name": "MYZAP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRSTSTVTLFSGSGSRTPGAPSRRANVCRLRLTVPPESPVSEPSEKKLERKEQHRDLSNGEPTRKLPHGVVYGVVRRSDQNQQKEMVVYGWTTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSISQAQQDYLENHIQTQSSALDSFNAMNSALASDSISLQKTLVDVTLENSSIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTRKLYSQYEEKLHEEQQRHSAEKEALLEETNNFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSAEITDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPRTEVETREIGVGCDLLPSQTGRTREIAMPSRNYTPYTRVLELTMKKTLT", "length": 466 }, "evidence": [ { "id": "F1N2J6", "url": "https://omabrowser.org/oma/group/F1N2J6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GRL7-1", "protein_name": "Myocardial zonula adherens protein isoform X1", "gene_name": "Myzap", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRSTSTVTLLSGGSAKSPGTPSRRANVCRLRLTVPPESPVPQQTEKKIERKDQPPELSNGEPTRKLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSQAQKDYLDSHIQAQSSALDSFNAMNSALASDSVGLQKTLVDVTLENSNIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMKVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGEIADSDKDRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREVGVGCDLLPSPTGRTREIMMPSRSYTPYTRVLELTSKKTLT", "length": 466 }, "evidence": [ { "id": "F1N2J6", "url": "https://omabrowser.org/oma/group/F1N2J6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0CAP1-1", "protein_name": "Myocardial zonula adherens protein", "gene_name": "MYZAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT", "length": 466 }, "evidence": [ { "id": "F1N2J6", "url": "https://omabrowser.org/oma/group/F1N2J6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3UIJ9-1", "protein_name": "Myocardial zonula adherens protein", "gene_name": "Myzap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRSTSTVTLFSGGGAKSPGTPSRRANVCRLRLTVPPENPVPQQTEKKIERKDQPPELSNGESTKRLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSFNAMNAALASDSVGLQKTLVDVTLENSHIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQKIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADSDKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSPTGRTREITMPSRSYTPYTRVLELSSKKTLT", "length": 466 }, "evidence": [ { "id": "F1N2J6", "url": "https://omabrowser.org/oma/group/F1N2J6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "I band", "id": "GO:0031674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031674", "evidence": [ { "database": "UniProtKB", "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ], "pmid": "" }, { "name": "RNA polymerase II, core complex", "id": "GO:0005665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005665", "evidence": [ { "database": "UniProtKB", "id": "F1N2J6", "url": "https://www.uniprot.org/uniprotkb/F1N2J6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 446, "end_pos": 448 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2S1-1", "uniprot_ac": "F1N2S1", "uniprot_id": "F1N2S1_BOVIN", "mass": { "chemical_mass": 70203.0, "monoisotopic_mass": 70203.0 }, "refseq": {}, "gene_names": [ { "name": "ASB2", "type": "recommended", "evidence": [ { "id": "F1N2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box protein 2", "type": "recommended", "evidence": [ { "id": "F1N2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB2", "url": "https://www.uniprot.org/uniprotkb/F1N2S1", "locus": { "chromosome": "21", "start_pos": 58530360, "end_pos": 58579232, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007109", "url": "https://www.ensembl.org/id/ENSBTAG00000007109" } ] } } ], "crossref": [ { "id": "F1N2S1", "url": "https://alphafold.ebi.ac.uk/entry/F1N2S1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007109", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007109", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03721", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03721", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WTCIKEK", "url": "https://omabrowser.org/oma/group/WTCIKEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2S1", "url": "https://www.orthodb.org/?gene=F1N2S1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123:SF140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123:SF140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24171:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24171:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13606", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13606", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1ML99", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML99-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEISARGRPRAIGQEEYNLYSSLSEDELVQMAIEQSLADKTRGPTTTETTVPTRVNREPAHFYPWTRSSVSPESAPTSAPKGLFQEVMQKYNRSKSSQLAPVDPVLKAIKEDDEEALTAMIKAGKNLSEPNKEGWLPLHEAAYYGQLNCLKALHRAYPAVIDQRTLQEETALYLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQYKADTNHRCNRGWTALHESVARNDLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDSASALYEACKNGHEEVVEFLLSQGADANKTNKDGMLPLHIASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNNDEVLEALLGARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVINPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCNGEPCFSCLYGNGPHPPAPPPSNRFNDAPASDKAPSAVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 633, "header": "tr|F1N2S1-1|F1N2S1_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 2 OS=Bos taurus OX=9913 GN=ASB2 PE=3 SV=2 CANONICAL=F1N2S1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ML99-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML99/entry", "sequence": { "sequence": "MAGPSNEEPARWGWVTDLAWRPSFALLVPHPGEFLVHLLLGPSPARPKTECFSSWDLPLTTSHIFWGFLQGPKIIWRHSSCIQTQGGPGHLLWFRALCLSVSLPRALPPSSFLPPAMTRFSYTEYFSLFHSCPAPSRSSVSPESAPTSAPKGLFQEVMQKYNRSKSSQLAPVDPVLKAIKEDDEEALTAMIKAGKNLSEPNKEGWLPLHEAAYYGQLNCLKALHRAYPAVIDQRTLQEETALYLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQYKADTNHRCNRGWTALHESVARNDLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDSASALYEACKNGHEEVVEFLLSQGADANKTNKDGMLPLHIASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNNDEVLEALLGARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVINPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCNGEPCFSCLYGNGPHPPAPPPSNRFNDAPASDKAPSAVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 701, "header": "tr|A0A3Q1ML99-1|F1N2S1_BOVIN Computationally mapped isoform of Ankyrin repeat and SOCS box protein 2 OS=Bos taurus OX=9913 GN=ASB2 PE=3 SV=1 CANONICAL=F1N2S1-1" }, "locus": { "chromosome": "21", "start_pos": 58556736, "end_pos": 58530912, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087131.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087131.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072444.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072444.2" } ] } }, { "isoform_ac": "F1N2S1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1/entry", "sequence": { "sequence": "MATEISARGRPRAIGQEEYNLYSSLSEDELVQMAIEQSLADKTRGPTTTETTVPTRVNREPAHFYPWTRSSVSPESAPTSAPKGLFQEVMQKYNRSKSSQLAPVDPVLKAIKEDDEEALTAMIKAGKNLSEPNKEGWLPLHEAAYYGQLNCLKALHRAYPAVIDQRTLQEETALYLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQYKADTNHRCNRGWTALHESVARNDLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDSASALYEACKNGHEEVVEFLLSQGADANKTNKDGMLPLHIASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNNDEVLEALLGARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVINPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCNGEPCFSCLYGNGPHPPAPPPSNRFNDAPASDKAPSAVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 633, "header": "tr|F1N2S1-1|F1N2S1_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 2 OS=Bos taurus OX=9913 GN=ASB2 PE=3 SV=2 CANONICAL=F1N2S1-1" }, "locus": { "chromosome": "21", "start_pos": 58564579, "end_pos": 58530912, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038558.5", "url": "https://www.ensembl.org/id/ENSBTAT00000038558.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038371.4", "url": "https://www.ensembl.org/id/ENSBTAP00000038371.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZZK0-1", "protein_name": "Ankyrin repeat and SOCS box containing 2", "gene_name": "ASB2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATQISARGTQPAIGQEEYNLYSSLSEDELVQMAIEQSLADKTRGPTATEAAVSTRVNREPAHFYPWTRSTVSPESPPTSAPKGLFQEVMQKYKSSRMAPVDPVLKAIKEGDEEALKAMIKAGKNLAEPNKDGWLPLHEAAYYGQLSCLKTLHQAYPAVIDQRTLQEETALYLATCRGHLDCLQSLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQYNADTNHRCNRGWTALHESVARNDLEVMEILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEEVVEFLLSQGADANKANKDGMLPLHIASKRGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNNDEVLEALLNARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVINPLLVAIRHGCLRTMQLLLDHGANIDAYITTHPTAFPATIMFAMKCLSLLKFLMDLGCNGEPCFSCLYGNGPHPPPPPPSNRFNDTPATDKPPGVVQFCEILSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLQVRKAIGNTV", "length": 607 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MFE7-1", "protein_name": "Ankyrin repeat and SOCS box protein 2", "gene_name": "Asb2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATEITTRGRQRAIGHEEYSLYSSLSEEELVQMAIEQSLADKTRGQTPAETTVPSQTNHQPGHFHSWTRSSSPPESPPSRAPLGLFQGVMQKYSSSLFKTSQMAAMDPVLKAIKEGDEEALKVMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADTNHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDGVLEALLAARFDVNAPLAPERSRLYEDRRSSALYFAVVNNNVYATELLLLAGADPNSDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 634 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YZ98-1", "protein_name": "Ankyrin repeat and SOCS box containing 2", "gene_name": "ASB2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATTAANTQRQTIGSEEYSLYSSLSEDELINMAIQQSLGEDPVGHAAAQGHPKPLGGGPSEAAAPSRANSHNPPYHLYPWQRLAARGRIQPPNAGAAWAVRRRYDGSLFSTAQPIELDPVVAAIRDGDEKEICNMMKSGKDLSEPNKDGWLPLHEAAYYGQVGCLRLLQKAYPGTIDQRTLNEETALFLATSRGNLDCLLALLQAGAEPDISNKARETPLYKACERKNAEAARLLVQYNADTNHRCNRGWTALHEAVSRNDLEIMDILVKGGAKIESTNSYGITSLFVAAESGQLEALRYLAKCGADINTQASDSASALYEACKNGHVHIVEFLLSQGADANKANKDGLLPLHIAAKKGICEIVSMLIPVTSRIRVKRSGISPLHLAAERNNDDILEELIDAGYEVNTTLSNERSCLYEDRRTTPLYFAVFNNNIYATELLLQAGANPNIDLINPLLISIRHGCLTTMKLLLDHGANIDAYISSHPTTFPATIMFSMKYLSVLKYLLDLGCDAVSCFQCQYGNCPHPALNYRRDRFNDPQLSKEPTITQFCDMVSAPEISRWAGPIIDVLLDYVGNVQLCSRLKEHIDSYEDWAVIKEKAEPPRPLAHLCRVKVRSLIGRNRIKLIDTLPLPYRLIRYLQHDYTQ", "length": 645 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AC58I5B0-1", "protein_name": "Ankyrin repeat and SOCS box protein 2 isoform X1", "gene_name": "asb2a.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVALQFALSSHSKKVTVSSPDWASWRVCVEFACSPRGGLGFFQELRFPPQSKDIGTIMAATHVSLPGTTGTNLEFADYSLYSNLSDDELLHLAIERSLADAHSSGSGTENLKTPAALNKPSSAAATAACQTPSRPPQQQQRQQTVQAACPANPPREKIDLENVCSVSHFVTGYGKPMVAYRRYDGSMQLVPEPEEELEPIAKAISEGDVGTVRLMVKQPGCNLLKPNKEGWIPLHEAAYYGQDQCVKILLRAQPGMINQRTLRDQTPLMLAVSRENLACVEILLEKGADPEIPNKEKETPLYKACEKENPALVAMLLNHGALVNKSCIQGWTALHESVCRNNVEICEMLMKAGAKVSLPNKYGITPIFVAAQSGKVEALRMLLKNGADLNSQASDGATALYEACKNGHEDIVEFLLSQNADANKAGKTGLLPIHIAAQRGKDGKDLLTFGCTRKNISATKIIAMLIPATSRARVRRSGISPLHLAAERNRNDIVEVLIEAGFDVNAMLSEDRSMMYEDRRSTALYFAVINNNIEATTMLLEAGANPNLDTFKPLLVALRQGCIQTVTLLVEHGADVNANIPTHPTSFPASVMFCMKYLSLLKYLMDNGCDALSCFNCVYGSNPHPPIKPRRNPRYDSDESREKTCVLFCEVISTENYSRWSGPIIDVLLDYVGHVKLCARLVEHLDSYHEWQCIKEKAMPPRPLMQLCRLKIRTLLGINRLKKIHKLPVPPRLIKFLNHQEREYEM", "length": 746 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5U2S6-1", "protein_name": "Ankyrin repeat and SOCS box protein 2", "gene_name": "Asb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTEISTRGRQRAIGHEEYSLYSSLSEEELVQMAIEQSLADKTRGPTPAETSVSSQTNHQPGHIHPWTRSSSPPESPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNTPLAPERARLYEDRRTSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRSGRFNDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 634 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K0L0-1", "protein_name": "Ankyrin repeat and SOCS box protein 2", "gene_name": "Asb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATEISTRGRQRAIGHEEYSLYSSLSEEELLQMAIEQSLADKTRGPTPAEASASSQTNHQPGHFHPWTRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 634 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96Q27-2", "protein_name": "Ankyrin repeat and SOCS box protein 2", "gene_name": "ASB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATQISTRGSQCTIGQEEYSLYSSLSEDELVQMAIEQSLADKTRGPTTAEATASACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 635 }, "evidence": [ { "id": "F1N2S1", "url": "https://omabrowser.org/oma/group/F1N2S1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "cardiac muscle cell differentiation", "id": "GO:0055007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055007", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" }, { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "F1N2S1", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S1" }, { "id": "PS50225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000259", "start_pos": 584, "end_pos": 633, "start_aa": "Ile", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1F8-1", "uniprot_ac": "F1N1F8", "uniprot_id": "F1N1F8_BOVIN", "mass": { "chemical_mass": 374373.0, "monoisotopic_mass": 374373.0 }, "refseq": { "ac": "XP_005217426", "name": "centromere protein F", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217426" }, "gene_names": [ { "name": "CENPF", "type": "recommended", "evidence": [ { "id": "F1N1F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ] }, { "name": "CENPF", "type": "synonym", "evidence": [ { "id": "XP_005217426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217426" } ] } ], "protein_names": [ { "name": "Centromere protein F", "type": "synonym", "evidence": [ { "id": "F1N1F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F8/entry#names_and_taxonomy" } ] }, { "name": "centromere protein F", "type": "synonym", "evidence": [ { "id": "XP_005217426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217426" } ] }, { "name": "mitosin", "type": "synonym", "evidence": [ { "id": "XP_005217426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217426" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPF", "url": "https://www.uniprot.org/uniprotkb/F1N1F8", "locus": { "chromosome": "16", "start_pos": 68929293, "end_pos": 68992065, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024449", "url": "https://www.ensembl.org/id/ENSBTAG00000024449" } ] } } ], "crossref": [ { "id": "ENSBTAG00000024449", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024449", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533089", "url": "https://www.ncbi.nlm.nih.gov/gene/533089", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EQPNEQH", "url": "https://omabrowser.org/oma/group/EQPNEQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NIE5", "url": "https://www.orthodb.org/?gene=A0A3Q1NIE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1F8", "url": "https://www.orthodb.org/?gene=F1N1F8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18874", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18874", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18874:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18874:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10473", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10473", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10481", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10481", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10490", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10490", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005217426", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217426", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIE5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIE5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1F8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1F8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWALEEWKEGLPTRALQKIQELEGQLDKLKKERQQRQFQLETLEAALQKQKQKVENEKTEGANLKRENQSLMEICENLEKTKQKISHELQVKESQVNFQEGQLNSSKKQIEKLEQELKRCKSELERSQQAAQSADVSLNSCLTPQKIFATPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTIPQSTMNHRDIARHQASSSVFSWQQEKTPSRLSSNTLKTPVRRDFSASHFSGEQEVTPSRSTLQIGKTDANSSFCDNSSNSHLLDQLKAQNQELRSKMSELELRLQGQEKEMKGQVNKLQELQLQLEKAKVELNEKEKVLNKNRDELVRTTSQYDQASAKCTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECTQMKARLTQELQQAKNTYNILQAELDKVTSVKQQIEKKLEEFKQNFSKTEQALQASQTKENELRRSSEEMKRENSLLKSQSEQRAREVCHLEEELKKAKQCLSQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLALADLEKQRDCSQDLLKKREHHIEQLNEKLSKTERESEALLSALELKKKEYEELKEEKTLFSRWKSENEQLLNQMESEKESLQSKVNHLETCLKTQQIKSHEYNERVRTLEMERENLNVEIRNLQNVIDSKTAEAETQKRAYGELQQKAEFSDQKHEKEIENMCLKISHLTGQVEDLEHKLQLLSSEIMDKDQRYQDLHAESESLRDLLKSRDSSAMTIEPHQRSRLAFEQQSALNNSFANIIGEQESVPSERSRCHVATDQSPKSSSMLQNRVVSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSVHQNVVAETLAALESKERELQLLNEKLETEQAETGELKKNNHLLQESLKELQFLSETLSLEKKELNSIISLNKKDIEELTQENGTLKEINATLTQEKMNLLQKTESFSNCIDERDRSISELSNQYKQERLTLLQRCEETGNAFQDLSEKYKAVQEKNSKLECLLSECTGVCEDRKNELGQLKETFAREHQAFVSQLALAEERNQNLIVELETVQQALQSEITDIQNSSKRETDGLKQEIMNLKEEQNKMQQEVSALLQENEHLMELMKTKHEHQCLELEPIQDSEKEEREINTCHLQLPMDLDVKDTSPDTCNAQLVQVESKVRNMELKLQKSEKEECLQYELQTRELETEDLQQDPQSQDISGLGDSEIDPEEKYISVLQELSTSQQDNAHLQCSLQTAMNKLNELEKMCEALQVEKSELISELNDSRSECITATSKMAEEVGKLVNEVETLNDENALLQGELVEETPEGEFGEQQDEQTSVNLNPLDDSNFYEHLTMSSKEVQMHFAELQEKFSSLQSEHKILHEQHCLMSSKMSELQSYVDTLKAENSVLSMSLRSSQGDLVKEVPPGPGEEHLLSLSFSCVTDSPGKASLGESSFYKDLLEHTTETSLLNNLEGTVSANQSNVEEVSCSSLEEENLTEKEIPSVPLRSARELETLCQTYLESLKQLEEEIESQGITKNKEIKELKELLSSSREELDDLRKQYLSENEQWQQKLTDVTAEMESKLAAEKRHAEHLTLELEVARLQLQGLDLSSRSLLGTDIEDAILGGNDSCDIRESEEYISETKERTPKHEIHQICEKDVQQDLSLEMEKITKTGATKLTEEWSREQSSESSHETPVEDPAQGCSGCISELSLSGPNASVPRDFLENQVTIQSLELKVKETSNENLRLLHGIEERDQKVENLLNEIKELDSKFHLLEVQLTTKIEACVALEKIVEELKKEKLDLNEKLESFSCHNQREESSGGLTSNLEMVTSKFPHEGIEDDVAKVTDNWREKCLQVENELQRIQSEKDSMEHHALSAEASLEAVQTEKLYLEKDNENKQTVITCLEEGLSVVTSERDQLRGELDTLSKENQELDQMSEKMKEKIRELESHQSECLHLQEWLQSLEKDSQALSLVRSELENQIEQLNKEKDSLVWESESLQTKLSESEHEKLAITKALEAALMEKGEVAVRLSSTQEEVHQLRKGIEKLRVRIEADEKKQLHVSEKLKESERRNDSLQDKVETLERELQMAEENQELVILDAENCKAEVETLKTQIELMTERLKDLELDLVTIRSEKENLLKQLQEKQGQASELDTLLSSLKNLLEEKEREKIQTKEEAKSAVEMLQTQLRELTEEIAALCDDQETWKVEEQSLDSPAQEVQQLRNNIEKLKVHLDIDKKKQLQILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEKMDQNLRGLQLDLVNIRSEKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQTQLKELSEEVAILCVDQETWKVEEQSLDSPLEEIQQLRNNIGKLKVCLDADKKQQLHILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEEMDQNLRGLQLDLVNIRSDKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQKELEELNEKMAALGNDQETRKVKEQSLSSQVDSLEHEKAQLLQDLDDAKSNYMILQSSVNDLIQEVEDGKQKLEKKDEEISILKSQTRDQEQLVSKLSQMEGEQQLWKKQKADLENLMVELEQKIQVLQSKNDALQDTLEALQNSSRNLEKELELTKLEKMSFVEKVNTMTVKETELQKEIHAVIQKTVALKEEFSGEKNRLMEELNLMLEEVKSSKGQLKELMLENSELKKSLDCVHKDRMEEQGKMRGEIAEYQLRLQEAENKHQALLLDTNKQHEMEIQTYREKLTSKEECLSSQKVEIDLLKSSKEELNNSLKATTEILEELKKTKMENLKHADKLKKENDRAQSKIKLLVKSCKQLEEEKVMLQKELSHLEAAQEKQRADTVVDANVDELITEMKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVARLSSQQSKLNLRRSPLVNSLAPGPSPVPSATEKKLPSGQNKSSGKRQRSSGIREDGGETTPSTPETFSKKSRKAIRSGTHLAEDAEDAEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLAASPPSLDKENLTETSKPTAGGSRSQKVKVSQQSPVDSGTAFRDPIGRSLSISNLPERSPVGSPREGLRAKRGRHAPSPESSLESKGSENCRVQ", "length": 3259, "header": "tr|F1N1F8-1|F1N1F8_BOVIN Isoform 1 of Centromere protein F OS=Bos taurus OX=9913 GN=CENPF PE=4 SV=3 CANONICAL=F1N1F8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NIE5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIE5/entry", "sequence": { "sequence": "MSWALEEWKEGLPTRALQKIQELEGQLDKLKKERQQRQFQLETLEAALQKQKQKVENEKTEGANLKRENQSLMEICENLEKTKQKISHELQVKESQVNFQEGQLNSSKKQIEKLEQELKRCKSELERSQQAAQSADVSLNSCLTPQKIFATPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTIPQSTMNHRDIARHQASSSVFSWQQEKTPSRLSSNTLKTPVRRDFSASHFSGEQEVTPSRSTLQIGKTDANSSFCDNSSNSHLLDQLKAQNQELRSKMSELELRLQGQEKEMKGQVNKLQELQLQLEKAKVELNEKEKVLNKNRDELVRTTSQYDQASAKCTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECTQMKARLTQELQQAKNTYNILQAELDKVTSVKQQIEKKLEEFKQNFSKTEQALQASQTKENELRRSSEEMKRENSLLKSQSEQRAREVCHLEEELKKAKQCLSQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLALADLEKQRDCSQDLLKKREHHIEQLNEKLSKTERESEALLSALELKKKEYEELKEEKTLFSRWKSENEQLLNQMESEKESLQSKVNHLETCLKTQQIKSHEYNERVRTLEMERENLNVEIRNLQNVIDSKTAEAETQKRAYGELQQKAEFSDQKHEKEIENMCLKISHLTGQVEDLEHKLQLLSSEIMDKDQRYQDLHAESESLRDLLKSRDSSAMTIEPHQRSRLAFEQQSALNNSFANIIGEQESVPSERSRCHVATDQSPKSSSMLQNRVVSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSVHQNVVAETLAALESKERELQLLNEKLETEQAETGELKKNNHLLQESLKELQFLSETLSLEKKELNSIISLNKKDIEELTQENGTLKEINATLTQEKMNLLQKTESFSNCIDERDRSISELSNQYKQERLTLLQRCEETGNAFQDLSEKYKAVQEKNSKLECLLSECTGVCEDRKNELGQLKETFAREHQAFVSQLALAEERNQNLIVELETVQQALQSEITDIQNSSKRETDGLKQEIMNLKEEQNKMQQEVSALLQENEHLMELMKTKHEHQCLELEPIQDSEKEEREINTCHLQLPMDLDVKDTSPDTCNAQLVQVESKVRNMELKLQKSEKEECLQYELQTRELETEDLQQDPQSQDISGLGDSEIDPEEKYISVLQELSTSQQDNAHLQCSLQTAMNKLNELEKMCEALQVEKSELISELNDSRSECITATSKMAEEVGKLVNEVETLNDENALLQGELVEETPEGEFGEQQDEQTSVNLNPLDDSNFYEHLTMSSKEVQMHFAELQEKFSSLQSEHKILHEQHCLMSSKMSELQSYVDTLKAENSVLSMSLRSSQGDLVKEVPPGPGEEHLLSLSFSCVTDSPGKASLGESSFYKDLLEHTTETSLLNNLEGTVSANQSNVEEVSCSSLEEENLTEKEIPSVPLRSARELETLCQTYLESLKQLEEEIESQGITKNKEIKELKELLSSSREELDDLRKQYLSENEQWQQKLTDVTAEMESKLAAEKRHAEHLTLELEVARLQLQGLDLSSRSLLGTDIEDAILGGNDSCDIRESEEYISETKERTPKHEIHQICEKDVQQDLSLEMEKITKTGATKLTEEWSREQSSESSHETPVEDPAQGCSGCISELSLSGPNASVPRDFLENQREESSGGLTSNLEMVTSKFPHEGIEDDVAKVTDNWREKCLQVENELQRIQSEKDSMEHHALSAEASLEAVQTEKLYLEKDNENKQTVITCLEEGLSVVTSERDQLRGELDTLSKENQELDQMSEKMKEKIRELESHQSECLHLQEWLQSLEKDSQALSLVRSELENQIEQLNKEKDSLVWESESLQTKLSESEHEKLAITKALEAALMEKGEVAVRLSSTQEEVHQLRKGIEKLRVRIEADEKKQLHVSEKLKESERRNDSLQDKVETLERELQMAEENQELVILDAENCKAEVETLKTQIELMTERLKDLELDLVTIRSEKENLLKQLQEKQGQASELDTLLSSLKNLLEEKEREKIQTKEEAKSAVEMLQTQLRELTEEIAALCDDQETWKVEEQSLDSPAQEVQQLRNNIEKLKVHLDIDKKKQLQILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEKMDQNLRGLQLDLVNIRSEKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQTQLKELSEEVAILCVDQETWKVEEQSLDSPLEEIQQLRNNIGKLKVCLDADKKQQLHILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEEMDQNLRGLQLDLVNIRSDKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQKELEELNEKMAALGNDQETRKVKEQSLSSQVDSLEHEKAQLLQDLDDAKSNYMILQSSVNDLIQEVEDGKQKLEKKDEEISILKSQTRDQEQLVSKLSQMEGEQQLWKKQKADLENLMVELEQKIQVLQSKNDALQDTLEALQNSSRNLEKELELTKLEKMSFVEKVNTMTVKETELQKEIHAVIQKTVALKEEFSGEKNRLMEELNLMLEEVKSSKGQLKELMLENSELKKSLDCVHKDRMEEQGKMRGEIAEYQLRLQEAENKHQALLLDTNKQHEMEIQTYREKLTSKEECLSSQKVEIDLLKSSKEELNNSLKATTEILEELKKTKMENLKHADKLKKENDRAQSKIKLLVKSCKQLEEEKVMLQKELSHLEAAQEKQRADTVVDANVDELITEMKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVARLSSQQSKLNLRRSPLVNSLAPGPSPVPSATEKKLPSGQNKSSGKRQRSSGIREDGGETTPSTPETFSKKSRKAIRSGTHLAEDAEDAEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLAASPPSLDKENLTETSKPTAGGSRSQKVKVSQQSPVDSGTAFRDPIGRSLSISNLPERSPVGSPREGLRAKRGRHAPSPESSLESKGSENCRVQ", "length": 3171, "header": "tr|A0A3Q1NIE5-1|F1N1F8_BOVIN Computationally mapped isoform of Centromere protein F OS=Bos taurus OX=9913 GN=CENPF PE=4 SV=1 CANONICAL=F1N1F8-1" }, "locus": { "chromosome": "16", "start_pos": 68989000, "end_pos": 68930070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079772.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079772.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071796.1" } ] } }, { "isoform_ac": "A0AAA9SYD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD6/entry", "sequence": { "sequence": "MSWALEEWKEGLPTRALQKIQELEGQLDKLKKERQQRQFQLETLEAALQKQKQKWKLRVLTTGSPKKSPAAAKLLQSSLTLCDPINGSPPGSPVPGILQVENEKTEGANLKRENQSLMEICENLEKTKQKISHELQVKESQVNFQEGQLNSSKKQIEKLEQELKRCKSELERSQQAAQSADVSLNSCLTPQKIFATPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTIPQSTMNHRDIARHQASSSVFSWQQEKTPSRLSSNTLKTPVRRDFSASHFSGEQEVTPSRSTLQIGKTDANSSFCDNSSNSHLLDQLKAQNQELRSKMSELELRLQGQEKEMKGQVNKLQELQLQLEKAKVELNEKEKVLNKNRDELVRTTSQYDQASAKCTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECTQMKARLTQELQQAKNTYNILQAELDKVTSVKQQIEKKLEEFKQNFSKTEQALQASQTKENELRRSSEEMKRENSLLKSQSEQRAREVCHLEEELKKAKQCLSQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLALADLEKQRDCSQDLLKKREHHIEQLNEKLSKTERESEALLSALELKKKEYEELKEEKTLFSRWKSENEQLLNQMESEKESLQSKVNHLETCLKTQQIKSHEYNERVRTLEMERENLNVEIRNLQNVIDSKTAEAETQKRAYGELQQKAEFSDQKHEKEIENMCLKISHLTGQVEDLEHKLQLLSSEIMDKDQRYQDLHAESESLRDLLKSRDSSAMTIEPHQRSRLAFEQQSALNNSFANIIGEQESVPSERSRCHVATDQSPKSSSMLQNRVVSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSVHQNVVAETLAALESKERELQLLNEKLETEQAETGELKKNNHLLQESLKELQFLSETLSLEKKELNSIISLNKKDIEELTQENGTLKEINATLTQEKMNLLQKTESFSNCIDERDRSISELSNQYKQERLTLLQRCEETGNAFQDLSEKYKAVQEKNSKLECLLSECTGVCEDRKNELGQLKETFAREHQAFVSQLALAEERNQNLIVELETVQQALQSEITDIQNSSKRETDGLKQEIMNLKEEQNKMQQEVSALLQENEHLMELMKTKHEHQCLELEPIQDSEKEEREINTCHLQLPMDLDVKDTSPDTCNAQLVQVESKVRNMELKLQKSEKEECLQYELQTRELETEDLQQDPQSQDISGLGDSEIDPEEKYISVLQELSTSQQDNAHLQCSLQTAMNKLNELEKMCEALQVEKSELISELNDSRSECITATSKMAEEVGKLVNEVETLNDENALLQGELVEETPEGEFGEQQDEQTSVNLNPLDDSNFYEHLTMSSKEVQMHFAELQEKFSSLQSEHKILHEQHCLMSSKMSELQSYVDTLKAENSVLSMSLRSSQGDLVKEVPPGPGEEHLLSLSFSCVTDSPGKASLGESSFYKDLLEHTTETSLLNNLEGTVSANQSNVEEVSCSSLEEENLTEKEIPSVPLRSARELETLCQTYLESLKQLEEEIESQGITKNKEIKELKELLSSSREELDDLRKQYLSENEQWQQKLTDVTAEMESKLAAEKRHAEHLTLELEVARLQLQGLDLSSRSLLGTDIEDAILGGNDSCDIRESEEYISETKERTPKHEIHQICEKDVQQDLSLEMEKITKTGATKLTEEWSREQSSESSHETPVEDPAQGCSGCISELSLSGPNASVPRDFLENQVTIQSLELKVKETSNENLRLLHGIEERDQKVENLLNEIKELDSKFHLLEVQLTTKIEACVALEKIVEELKKEKLDLNEKLESFSCHNQREESSGGLTSNLEMVTSKFPHEGIEDDVAKVTDNWREKCLQVENELQRIQSEKDSMEHHALSAEASLEAVQTEKLYLEKDNENKQTVITCLEEGLSVVTSERDQLRGELDTLSKENQELDQMSEKMKEKIRELESHQSECLHLQEWLQSLEKDSQALSLVRSELENQIEQLNKEKDSLVWESESLQTKLSESEHEKLAITKALEAALMEKGEVAVRLSSTQEEVHQLRKGIEKLRVRIEADEKKQLHVSEKLKESERRNDSLQDKVETLERELQMAEENQELVILDAENCKAEVETLKTQIELMTERLKDLELDLVTIRSEKENLLKQLQEKQGQASELDTLLSSLKNLLEEKEREKIQTKEEAKSAVEMLQTQLRELTEEIAALCDDQETWKVEEQSLDSPAQEVQQLRNNIEKLKVHLDIDKKKQLQILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEKMDQNLRGLQLDLVNIRSEKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQTQLKELSEEVAILCVDQETWKVEEQSLDSPLEEIQQLRNNIGKLKVCLDADKKQQLHILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEEMDQNLRGLQLDLVNIRSDKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQKELEELNEKMAALGNDQETRKVKEQSLSSQVDSLEHEKAQLLQDLDDAKSNYMILQSSVNDLIQEVEDGKQKLEKKDEEISILKSQTRDQEQLVSKLSQMEGEQQLWKKQKADLENLMVELEQKIQVLQSKNDALQDTLEALQNSSRNLEKELELTKLEKMSFVEKVNTMTVKETELQKEIHAVIQKTVALKEEFSGEKNRLMEELNLMLEEVKSSKGQLKELMLENSELKKSLDCVHKDRMEEQGKMRGEIAEYQLRLQEAENKHQALLLDTNKQHEMEIQTYREKLTSKEECLSSQKVEIDLLKSSKEELNNSLKATTEILEELKKTKMENLKHADKLKKENDRAQSKIKLLVKSCKQLEEEKVMLQKELSHLEAAQEKQRADTVVDANVDELITEMKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVARLSSQQSKLNLRRSPLVNSLAPGPSPVPSATEKKLPSGQNKSSGKRQRSSGIREDGGETTPSTPETFSKKSRKAIRSGTHLAEDAEDAEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLAASPPSLDKENLTETSKPTAGGSRSQKVKVSQQSPVDSGTAFRDPIGRSLSISNLPERSPVGSPREGLRAKRGRHAPSPESSLESKGSENCRVQ", "length": 3304, "header": "tr|A0AAA9SYD6-1|F1N1F8_BOVIN Computationally mapped isoform of Centromere protein F OS=Bos taurus OX=9913 GN=CENPF PE=4 SV=1 CANONICAL=F1N1F8-1" }, "locus": { "chromosome": "16", "start_pos": 68989000, "end_pos": 68930070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106970.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106970.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091476.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091476.1" } ] } }, { "isoform_ac": "F1N1F8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1F8/entry", "sequence": { "sequence": "MSWALEEWKEGLPTRALQKIQELEGQLDKLKKERQQRQFQLETLEAALQKQKQKVENEKTEGANLKRENQSLMEICENLEKTKQKISHELQVKESQVNFQEGQLNSSKKQIEKLEQELKRCKSELERSQQAAQSADVSLNSCLTPQKIFATPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTIPQSTMNHRDIARHQASSSVFSWQQEKTPSRLSSNTLKTPVRRDFSASHFSGEQEVTPSRSTLQIGKTDANSSFCDNSSNSHLLDQLKAQNQELRSKMSELELRLQGQEKEMKGQVNKLQELQLQLEKAKVELNEKEKVLNKNRDELVRTTSQYDQASAKCTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECTQMKARLTQELQQAKNTYNILQAELDKVTSVKQQIEKKLEEFKQNFSKTEQALQASQTKENELRRSSEEMKRENSLLKSQSEQRAREVCHLEEELKKAKQCLSQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLALADLEKQRDCSQDLLKKREHHIEQLNEKLSKTERESEALLSALELKKKEYEELKEEKTLFSRWKSENEQLLNQMESEKESLQSKVNHLETCLKTQQIKSHEYNERVRTLEMERENLNVEIRNLQNVIDSKTAEAETQKRAYGELQQKAEFSDQKHEKEIENMCLKISHLTGQVEDLEHKLQLLSSEIMDKDQRYQDLHAESESLRDLLKSRDSSAMTIEPHQRSRLAFEQQSALNNSFANIIGEQESVPSERSRCHVATDQSPKSSSMLQNRVVSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSVHQNVVAETLAALESKERELQLLNEKLETEQAETGELKKNNHLLQESLKELQFLSETLSLEKKELNSIISLNKKDIEELTQENGTLKEINATLTQEKMNLLQKTESFSNCIDERDRSISELSNQYKQERLTLLQRCEETGNAFQDLSEKYKAVQEKNSKLECLLSECTGVCEDRKNELGQLKETFAREHQAFVSQLALAEERNQNLIVELETVQQALQSEITDIQNSSKRETDGLKQEIMNLKEEQNKMQQEVSALLQENEHLMELMKTKHEHQCLELEPIQDSEKEEREINTCHLQLPMDLDVKDTSPDTCNAQLVQVESKVRNMELKLQKSEKEECLQYELQTRELETEDLQQDPQSQDISGLGDSEIDPEEKYISVLQELSTSQQDNAHLQCSLQTAMNKLNELEKMCEALQVEKSELISELNDSRSECITATSKMAEEVGKLVNEVETLNDENALLQGELVEETPEGEFGEQQDEQTSVNLNPLDDSNFYEHLTMSSKEVQMHFAELQEKFSSLQSEHKILHEQHCLMSSKMSELQSYVDTLKAENSVLSMSLRSSQGDLVKEVPPGPGEEHLLSLSFSCVTDSPGKASLGESSFYKDLLEHTTETSLLNNLEGTVSANQSNVEEVSCSSLEEENLTEKEIPSVPLRSARELETLCQTYLESLKQLEEEIESQGITKNKEIKELKELLSSSREELDDLRKQYLSENEQWQQKLTDVTAEMESKLAAEKRHAEHLTLELEVARLQLQGLDLSSRSLLGTDIEDAILGGNDSCDIRESEEYISETKERTPKHEIHQICEKDVQQDLSLEMEKITKTGATKLTEEWSREQSSESSHETPVEDPAQGCSGCISELSLSGPNASVPRDFLENQVTIQSLELKVKETSNENLRLLHGIEERDQKVENLLNEIKELDSKFHLLEVQLTTKIEACVALEKIVEELKKEKLDLNEKLESFSCHNQREESSGGLTSNLEMVTSKFPHEGIEDDVAKVTDNWREKCLQVENELQRIQSEKDSMEHHALSAEASLEAVQTEKLYLEKDNENKQTVITCLEEGLSVVTSERDQLRGELDTLSKENQELDQMSEKMKEKIRELESHQSECLHLQEWLQSLEKDSQALSLVRSELENQIEQLNKEKDSLVWESESLQTKLSESEHEKLAITKALEAALMEKGEVAVRLSSTQEEVHQLRKGIEKLRVRIEADEKKQLHVSEKLKESERRNDSLQDKVETLERELQMAEENQELVILDAENCKAEVETLKTQIELMTERLKDLELDLVTIRSEKENLLKQLQEKQGQASELDTLLSSLKNLLEEKEREKIQTKEEAKSAVEMLQTQLRELTEEIAALCDDQETWKVEEQSLDSPAQEVQQLRNNIEKLKVHLDIDKKKQLQILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEKMDQNLRGLQLDLVNIRSEKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQTQLKELSEEVAILCVDQETWKVEEQSLDSPLEEIQQLRNNIGKLKVCLDADKKQQLHILEKLKESEHQADFLKDTVENLERELKLSGENQEHVTLEAEKSKAEVETLKATVEEMDQNLRGLQLDLVNIRSDKEDLTKELQKEQSRVSELETLNSSFENLLREKEQEKVQMKEESKAAVEMLQKELEELNEKMAALGNDQETRKVKEQSLSSQVDSLEHEKAQLLQDLDDAKSNYMILQSSVNDLIQEVEDGKQKLEKKDEEISILKSQTRDQEQLVSKLSQMEGEQQLWKKQKADLENLMVELEQKIQVLQSKNDALQDTLEALQNSSRNLEKELELTKLEKMSFVEKVNTMTVKETELQKEIHAVIQKTVALKEEFSGEKNRLMEELNLMLEEVKSSKGQLKELMLENSELKKSLDCVHKDRMEEQGKMRGEIAEYQLRLQEAENKHQALLLDTNKQHEMEIQTYREKLTSKEECLSSQKVEIDLLKSSKEELNNSLKATTEILEELKKTKMENLKHADKLKKENDRAQSKIKLLVKSCKQLEEEKVMLQKELSHLEAAQEKQRADTVVDANVDELITEMKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVARLSSQQSKLNLRRSPLVNSLAPGPSPVPSATEKKLPSGQNKSSGKRQRSSGIREDGGETTPSTPETFSKKSRKAIRSGTHLAEDAEDAEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLAASPPSLDKENLTETSKPTAGGSRSQKVKVSQQSPVDSGTAFRDPIGRSLSISNLPERSPVGSPREGLRAKRGRHAPSPESSLESKGSENCRVQ", "length": 3259, "header": "tr|F1N1F8-1|F1N1F8_BOVIN Isoform 1 of Centromere protein F OS=Bos taurus OX=9913 GN=CENPF PE=4 SV=3 CANONICAL=F1N1F8-1" }, "locus": { "chromosome": "16", "start_pos": 68989000, "end_pos": 68930070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033913.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033913.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033816.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033816.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "E9PT83-1", "protein_name": "Centromere protein F", "gene_name": "Cenpf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEDGKTEGADLKRENQRLMEICENLEKTRQKLSHELQVKESQVNFQESQLSSCKKQIEKLEQELKRCKSEFERSQQSAEVSLNPCSTPQKLFTTPLTPSSTYEDLKEKYNKEVEDRKRLEAEVKALHAKKASLPVSQATMNHRDIARHQASSSVFSWQQDKTPSRLSSCSLRTPLRRDVSAAHFLGEEVTPNKSSVQIGRGDCSGLPDDPHCSQPLHQAKAQNQELKSKMNELELRLRGQEKEMKDQVNKFQELQLQLEKTKVDLIEKEKILNKTRDEVVRTTAQYEQAAAKCTALEQKLKNLTEELSCHRQNAESAKRSLEQRVKEKEKELREELSRQHQSFQALDHEYTQMKTRLTQELQQAKHSLSVLQLELEKVTSVKQQLERSLEEIRHKFSRAEQALQASQLTENELRRSSEEMKKENSLIRSQSEQRTREACRLEDELGKVKVCLSQSQSFAEEMRAKNTSQEIMLRDLQEKLNQQENSLTLEKLKLALADLEGQRDCSQDLLKKREHHIEQLNDKLNKIEKEFETLLSALELKKKECEELKEEKNQISCWKSENEKLINQIESEKEILLGKVNHLEASLKTQQISHDYSERVRTLEMERENLTVEIRNLHSLLDSKMVEIETQKQAYLELQQQSESSDQKHQKEMENMCLKANKLTGQVESLECKLQSLSGEVETKDQQYQDLRMEYETMRDSLQARGSSLVTDEKNQRSSSAFEEQPAVSHSFANLVGEKGSIYSERSDSSVDRGQSPENVAVLQSRVTLLESSLESQNQMNSDLQKQCEELLQIKGEIEENLIKADQIHQNFVAETNQRIGKLQEDAAVHQNIVAETLATLESREKELQLLKEQLEAQQTEVQKLEKNNCLLEGALKELQLLTDTLSSEKKEMNSIISLRKKDIEELTQANGALKEVNEALRQEKMNLLQQHEEITRCVAEGERSIAELSGQYKQERLLLLQRCEETETVLEGLRGDYKAAQENNAKLECMLSECTALCENKKNELEQLKETFAKEQQEFLTKLAFTEEQNRKLVLELETEPQTVRSEITNINKHPVSETDALGQESWSSKEEQKEKQKEVSNLTPENEQLMELTQTKHDYYHLEVEPVENSVKATEEEIRKSSSQYQMDIDTKDISLDSYKAQLVQLEALIKVMEVKLDRSEEEKNSLRQELQTIREELGTKTSQDTQSQARVGLKDCEVEAEEKYVSVLQELSTSQNENVHLQCSLQTAMNKLNELGKMCEVLRVEKLQLESELNDSRSECITATSQMAAEVEKLVNEMKMLNHENALSHGELMKDTADVEFDDKPNHTSVFLTPLDNSEQMTSSNKEVRVHFAELQEKFSCLQSEHKILHDQHCEVSSKMSALRSYVDTLKAENSVLSMNLRTLQGDLVKEKEPGAEDGHILPLSFCRTDSPTLTNFGENSFYKDVLEQTGDTSHLSLEGNASANPCDVDEVSYSSLEEENLTEKEIPFASLRTVEELEILCQVYLQSIKNLEEKIESQRIMKNKEIEELEQLLSSERKELSCLRKQYLSEKEQWQQKLTSVTLEMESKLAEEKQQTKNLSLELEVARLQLQELDLSSRSLLGTDLEGAVRGPNDGYAIKESEVYISETTEKTPKQDTNQTCDNDVQQDLCLETSVTETETTRLTGDGCEEQPSKISCEAPAEDRTQDYSECISELFSTPSVLVPMDVLEDQGSIQNLHLQKDTSNENLRLLPEVEDWDKKVESLLNEIKEADSKLSLQELQLKIKIATCIELEKIVKHLKKEETDLSEKLESLPCNQEVCPRVERSDLDFNLDMGDDELFRESTKDDAANTEDNYKEKFLDMERELTRIKSEKANIEHHIVSVKANLEVVQAEKLCLERDTESKQKVIVDLKGELFTVISERNRLREELDNVSKESKALDQMSKKMKEKIEELESHQRESLHHIGAVESEVKDKAELIQTLSFSVDELTKDKAHLQEQLQNLQNDSQGLSLAIGELEIQIGQLNKEKESLVKESQNFQVKLTESECEKQTISKALEVALMEKGEFAMRLSSTQEEVHQLRQGIEKLSVRIEADEKKHLSAVAKLKESQRESDSLKDKVENLERELEMSEENQELAILDSENLKAEVETLKAQMDEMAKSLRVFELDLVNVRSERENLAKQLQEKQSRVSELDELCSSLRSLSEEKEQARVQMERDSKSAMLMLQTQLKELWEEVAALYNDQETLKAQEQSLDQPGEEVHLLKSSIQKLKVHIDADKKKQCHILEQLKESKHHADLFKDRVENLEQELMLSEKNKEHLIFQAENSKAEIQTLKTEIQTMDQNLQDLELELTNTRSEKENLMKELKNEQEQISKLETINSSIERLLKDKEQEKVQVKEEARITVEMLQTQLKELNETVVSLCNDQEAYKTKEQNLGSRVQTLELEKAQLLQDLGEAKNKYIIFQSSVNALTQEVEAGKQKLEKEEEEVRTLKEQLKGQEQLVCKLARVEGEQQLCQKQKLELRSLTMELEQKVKVLQSENDALQTTYEALQSSYKSLEGELGLIKMEKMALVERVNTMTGKEAELQRELHDVEQKSTQLKEEYSKEKTRLTEDLEVVMEELKNTKVAHLKNVNHLEKEFQRAQGKIKLLLKSCKQLEGEKKMLQKELSQLEAAQKQRAGGWSWGSLVDSNVDELMTENKELKETLEEKIKEADKYLDKYCSLLISHEELEKTKEILEIQVARLSSRQNKQDLQSSPLLDSSVAGPSPSTSVSERKSTSGLNKTLGKRQRSSGIGENGNGTAPSTPETFSKKSRKSVSNSAHPAEDEEETEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLLGSSPTLGKENLVESSKPTAGGSRSQKVKVVQESSMDAHAVFQELPAKSLTANNMPGRNSTESPREGLRAKRACPASSPAAGPDPMNNENCRVQ", "length": 2985 }, "evidence": [ { "id": "F1N1F8", "url": "https://omabrowser.org/oma/group/F1N1F8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q3P4-1", "protein_name": "Centromere protein F", "gene_name": "Cenpf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSWALEEWKEGLPSRALQKIQELEGQLEKLKKEKQQRQFQLDSLEAALQKQKQKVEDGKTEGADLKRENQRLMEICEHLEKSRQKLSHELQVKESQVNLQESQLSSCKKQIEKLEQELKRCKSEFERSQQVAQSADVSLNPCSTPQKLFATPLTPSSTYEDLKEKYNKEVEERKRLEEEVKALHAKKVSLPVSQATMNHRDIARHQASSSVFPWQQENTPSRLSSDALKTPLRRDGSAAHFLGEEVSPNKSSMKTGRGDCSSLPGEPHSAQLLHQAKAQNQDLKSKMTELELRLQGQEKEMRSQVNKCQDLQLQLEKTKVELIEKERILNKTRDEVVRSTAQYDQAAAKCTTLEQKLKTLTEELSCHRQNAESAKRSLEQRIKEKEKELQEELSRQHQSFQALDSEYTQMKTRLTQELQQVKHLHSTLQLELEKVTSVKQQLERNLEEIRLKLSRAEQALQASQVAENELRRSSEEMKKENSLIRSQSEQRTREVCHLEEELGKVKVSLSKSQNFAEEMKAKNTSQEIMLRDLQEKLNQQENSLTLEKLKLALADLERQRNCSQDLLKKREHHIDQLNNKLNKIEKEFETLLSALELKKKECEELKEEKNQISFWKIDSEKLINQIESEKEILLGKINHLETSLKTQQVSPDSNERIRTLEMERENFTVEIKNLQSMLDSKMVEIKTQKQAYLELQQKSESSDQKHQKEIENMCLKANKLTGQVESLECKLQLLSSEVVTKDQQYQDLRMEYETLRDLLKSRGSSLVTNEDNQRSSEDNQRSSEDNQRGSLAFEQQPAVSDSFANVMGRKGSINSERSDCSVDGGRSPEHIAILQNRVTSLESSLESQNQMNSDLQMRCEELLQIKGEVEENLSKAEQIHQNFVAETNQCISKLQEDAAVHQNIVAETLATLESKEKELQLLKEKLEAQQTEVQKLNKNNCLLEGTLKELQLLSDTLSSEKKEMNSIISLSKKNIEELTQANEALKEVNEALEQEKMNLLQKHEKITSCIAEQERSIAELSDQYKQERLQLLQRCEETEAVLEDLRGNYKTAQENNAKLECMLSECTALCENRKNELEQLKETFAKEQQEFLTKLAFAEEQNRKLMLELEIEQQTVRSEITNTNKHSMSATDGLRQECLTLNEEQNEQQNEVSNLTHENEQLMELTQTKHDSYLAVEPVENSVKATEDEIGKSSSQYQMDIDTKDISLDSYKAQLVHLEALVRILEVQLDQSEEENKKLHLELQTIREELETKSSQDPQSQARTGLKDCDTAEEKYVSMLQELSASQNENAHLQCSLQTAVNKLNELGKMCDVLRVEKLQLESELNDSRTECITATSQMTAEVEKLVSEMKMLNHESALSQNELMKDTSGGEFHDKANHSSVFLTPLDSSNFCEQMTLSSKEVRVHFAELQEKFSCLQSEHKILHDQHCEVSSKMSALRSYVDTLKAENSALSMSLRTLQGDLVKEGEPAAEGGHGLPLSFCGADSPSLTNFGETSFYKDVLEQTGDTCHLSLEGNASANSCDLDEEFSSSLEEETLTEKESPPAPGRTVEGLEVLCQVYLQSLKNLEEKTESQRIMKNKEIEKLEQLLSSERKELSCLRKQYLSEKEQWQQKLTSVTLEMESKLAEEKQQTKTLSLELEVARLQLQELDLSSRSLLGTDLESVVRCQNDNYDIKESEVYISETTEKTPKQDTDQTCDKDIQQDLGLETSVTESETTRLTGEGCEEQPPKTNCEAPAEDKTQDCSECISELCSSSNVLVPMDVLEDQGSIQNLQLQKDTLNENLRLLPEVEDWDKKVESLLNEIMEADSKLSLQEVQLKMKIATCIQLEKIVKDLRKEKADLSEKLESLPCNQEVCLRVERSEEDLGFNLDMGANELLSKSTKDNATNTEDNYKEKFLDMERELTRIKSEKANIEHHILSVETNLEVVQAEKLCLERDTESKQKVIIDLKEELFTVISERNRLREELDNVSKESKALDQMSKKMKEKIEELESHQRESLRHIGAVESEVKDKADLIQTLSFNVGELTKDKAHLQEQLQNLQNDSQELSLAIGELEIQIGQLNKEKESLVKESQNFQIKLTESECEKQTISKALEVALKEKGEFAVQLSSAQEEVHQLRRGIEKLSVRIEADEKKHLSAVAKLKESQRESDSLKDTVETLERELERSEENQELAILDSENLKAEVETLKAQKDEMTKSLRIFELDLVTVRTERENLAKQLQEKQSRVSELDERCSSLRRLLEEKEQARVQMEEDSKSAMLMLQMQLKELREEVAALCNDQETLKAQEQSLDQPGEEVHHLKSSIRKLKVHIDADEKKHQNILEQLKESKHHADLLKDRVENLEQELILSEKNMIFQAEKSKAEIQTLKSEIQRMAQNLQDLQLELISTRSENENLMKELKKEQERVSDLETINSSIENLLKDKEQEKVQMKEEAKITVEMLQTQLKELNETVVSLCNDQEVSKTKEQNLGSQVQTLELEKAQLLQDLGEAKNKYIIFQSSVNALTQEVEAGKQKLEKGEKEIRTLKEQLKSQEQLVCKLAQVEGEQQLWQKQKLELRNVTMALEQKVQVLQSENNTLQSTYEALQNSHKSLESELGLIKLEKVALVERVSTISGKEAELQRELRDMLQKTTQLSEDYNKEKNRLTEEVEVLREELQNTKAAHLKSVNQLEKELQRAQGKIKLMLKSCRQLEGEKEMLQKELSQLEAAQQQRAGSLVDSNVDEVMTENKALKETLEEKVKEADKYLDKYCSLLISHEELEKAKEILEIEVARLKSRQSRQDLQSSPLLNSSIPGPSPNTSVSEMKSASGQNKASGKRQRSSGIWEHGKRAAPSTAETFSKKSRKSDSKSTRPAEHEQETEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRFATQKLVGSSPSLGKENVVESSKPTAGGSRSQKVKVVQESSADSHTAFQELPAKSLTASNIPGRNSTESPREGLRAKRAYPASSPAAGPDPTNNENCRVQ", "length": 2997 }, "evidence": [ { "id": "F1N1F8", "url": "https://omabrowser.org/oma/group/F1N1F8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1Q7X5-1", "protein_name": "Centromere protein F isoform X1", "gene_name": "cenpf", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSWAVEEWKDGLPAKALQKIQEIEAQLDKLKKERQQKQFQMDSLEATLQKQKQKMDSEKSEASALKRENQSLVESCEHLEKARQKLTHDIQTKEQQVNYLEGQLNSFKKQTDRLEQEVKKYKHELERSQTSHASEIQQLSTPQKTFATPATPNHWQQDSKITDLQEKYNREVEERKKLEAEIKVMHVKLLNQSSVSHKDIARQQTGSSIFPWQQDQKSSHQSLPVMETPSRRRNGASGMPWSYDDTPIKPHQQFTSGAPSDTVGSQQMEQLKNINQDLRSKVSELELRLQAHEKDMKNQINKFSEIQSQLEMAKKDVAEKDKLLNKSRDELTKATGQYEQSVSKCSAFEIKLKQVTEEMNCQRHNAESMHRSLEQKIKDQERESQKELAQLQSSYQALDQQFTQVKNKTSMEIQQAKKDHNVLQSEMDKVTALKNRLEKELEELKQKLLRSEQALQASQVKEAETKKKFEEMQREKNTLNCQLDQGMKRVKQLEDEKQNTEQILAKNRMMVDDLKVKTQTQNEELTELRKKMDHQSVSSAQELENLKKTLIEAEAKNMKTQAELQKLVHDVELKENKICAVEKENEELKMTSNSCQKELAEMKKEYDALLQWKTEKEQLINNAESNRNELLAKVADLEKDKDNLSNAHGDLQKKMQDLENEKIGLSGQIDSLKGELLVKCVELEEKGRVYEELQQQFGETKIKHKKEMDNLNQQITLTQGKVSELEAKLLQETSKLEGMEQAHGQLLAEYESACILAMSKDSIIEMNKTEIVHLQESFTLRDQELEKFKVEKDILAKECEDRLAQNKELEQQKLNTETSLMEVLAKFTLLESDLRCQKDLNAEIQGKYDELSKIKEDLVEKVSSLEKREKDLINEVESLLQKNKSLCSLEEQFNCLVAEAEETRSSLEKVKELQVQTTTELENQKTIAENLAIDLEEEKKKALSIKQENTQLKVKQEEIENKANDLFEKYESLQKLHDAVCQENANHLKEISIVTEALAEKDAMAERIALIKTELETSNNLSATLKNSLENLQTQFDSSVELISSLEKKLHDMSDEKSLLEISIKELTERHNKESEVYVSELETHIKKHKSLEEHISVLETELQNKSLETKTASEKLEVTTQEMIKLKQDFSLSENKLSVVTDSNKKVAKELEDMKQNVFLQEQEMEGLRLALSDLKNQEAAKSCEIETLKEKLQKAQSEHAKTSETLNEKNINMSKIKVQLEMLQMDLEDNENCINAFDAQVEELQGNVSILEAKLSESEAQRSNLESKLESVKEDYVKSSLEVSQLSACLEESQKEQQSRSVLVAELESLRVIHEQLKVSLEQENCKQANLEAMYTNLMDQKLKLESEIQELKADTQGSQKQIDQLKQANDRLASQIAEQQIHIEQLQSEKNLADTLNKEQTSGGNDQDICEMPFANTSLLPFEEDTAILGMSSPKGKHDSQEEPKTPLSAEEDYKDFALQEQMQNKSSDIEDMSHVLKETVRTMEEQTAIQIEQLKLQHATELQSMEEQMLNIKNELEAKLKEEKQHTEILSSQLEATMQQLQELDIASSSLLAADTSQNMGKFASGAQDDLIHHTEQSNSTLGIITESEHSNLETETLKEVLRKREEELLHLQSQFEVLESEMVIRKDLCLDMEGKICKMESEKTNGTDKLASIIQENEKLNKHIGELKEEIDSLTLQLQTSNCQLTDVMEMMESLEMAKGEWNEKFFQIESELKRVRSEKANLEKHILSMEADIEEMQEQKQKQEAELETARRTNCSLEQQLNITMAEGGRLKEELILCTDERESETHSLMKLKEKADLLEKRETDTKELIKELEDDIRVGKKQNEVASDQISVLLKEKEQLIQQSQNLENKIVLLNEDNERLLSELNDIKHNDSFTSRETENMSSKIHSLEDENVRLSQSLEMSLLEKGEIASRLISTQEEVAQMRQGIEKLKVRIESDERKKNHMSQLLKAAQRKADVLQDNIEKLEREKELSEQNLEDAILQAETAKAELEEIQAETQDLTKKIEEMTSELKDLKEEKYKLEQELDQKNKLIEELQLSIQEASVKLKSAEEATLNQEQMIKDFQFKVGAMEEELRLFQTEVESKEVKALELASHLLSLESENKEFAQRVLEYERSQEELHSSNQSLLKDFESKQQELSEENTQLRSQIAELQALSLIREEQDEELQKDKVELQSTIAQLEEKTQMQSTKMEVMQNSISSLEINIQQLEGQLDAMKLMNVELTGKLNSLQESSLHLETQHKQELCEAKEIQNALEINQNLLTCQLQESQKQIEEYKFSLEALAAEKDGLQKSISVIQESHDVQLKENNMRHEENLKRTQQQLEVELNALKENILVAEKNAAQYQSDLESIKSQNAEKDSALKELQNKWENCQKEKAELDSKITRLSKEKDSAMSKINLWMKSCKQLENEKQTLQEELQQQGQEIETLKASKEQAEGSSSSGALQEELEELKEALEEKSREADDSMDRYCSLMVKVHKLEDSNESLKNQLKQLSTQTKTPKSRRSLRSETSDLENSNPEGVTSGKRQRAIDDTPNKAQEALHNITKRLKAAAATPKAKQDDEDFRPEGLPELVQKGFADIPVGEMSPFIVRRTTAQRCSPRLAARTTAVLQSSGSAEHPAQISMQTAEGRTPNTVQKPKATPSRNVPLLSTLTNSPLKNSCERLAPVIEQKISRRSRSFKNSPQTSEQVTASPKQNDNCQVQ", "length": 2708 }, "evidence": [ { "id": "F1N1F8", "url": "https://omabrowser.org/oma/group/F1N1F8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P49454-1", "protein_name": "Centromere protein F", "gene_name": "CENPF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAVMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQRSPVDSGTILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ", "length": 3114 }, "evidence": [ { "id": "F1N1F8", "url": "https://omabrowser.org/oma/group/F1N1F8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q00402-1", "protein_name": "Nuclear migration protein NUM1", "gene_name": "NUM1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSHNNRHKKNNDKDSSAGQYANSIDNSLSQESVSTNGVTRMANLKADECGSGDEGDKTKRFSISSILSKRETKDVLPEFAGSSSHNGVLTANSSKDMNFTLELSENLLVECRKLQSSNEAKNEQIKSLKQIKESLSDKIEELTNQKKSFMKELDSTKDLNWDLESKLTNLSMECRQLKELKKKTEKSWNDEKESLKLLKTDLEILTLTKNGMENDLSSQKLHYDKEISELKERILDLNNENDRLLISVSDLTSEINSLQSNRTERIKIQKQLDDAKASISSLKRKVQKKYYQKQHTSDTTVTSDPDSEGTTSEEDIFDIVIEIDHMIETGPSVEDISEDLVKKYSEKNNMILLSNDSYKNLLQKSESASKPKDDELMTKEVAENLNMIALPNDDNYSKKEFSLESHIKYLEASGYKVLPLEEFENLNESLSNPSYNYLKEKLQALKKIPIDQSTFNLLKEPTIDFLLPLTSKIDCLIIPTKDYNDLFESVKNPSIEQMKKCLEAKNDLQSNICKWLEERNGCKWLSNDLYFSMVNKIETPSKQYLSDKAKEYDQVLIDTKALEGLKNPTIDFLREKASASDYLLLKKEDYVSPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELQRKYSELEKEVEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDVEFLKEKSAKLGHTVVSSEEYSELQRKYSELEKEVEQPSLAYLVEHAKATDHHLLSDSAYEELVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENSDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEELVKCKENPDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEELVKCKENPDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNKEYSELEKKLEQPSLEYLVKHAEQIQSKIISISDFNTLANPSMEDMASKLQKLEYQIVSNDEYIALKNTMEKPDVELLRSKLKGYHIIDTTTYNELVSNFNSPTLKFIEEKAKSKGYRLIEPNEYLDLNRIATTPSKEEIDNFCKQIGCYALDSKEYERLKNSLENPSKKFIEENAALLDLVLVDKTEYQAMKDNASNKKSLIPSTKALDFVTMPAPQLASAEKSSLQKRTLSDIENELKALGYVAIRKENLPNLEKPIVDNASKNDVLNLCSKFSLVPLSTEEYDNMRKEHTKILNILGDPSIDFLKEKCEKYQMLIISKHDYEEKQEAIENPGYEFILEKASALGYELVSEVELDRMKQMIDSPDIDYMQEKAARNEMVLLRNEEKEALQKKIEYPSLTFLIEKAAGMNKILVDQIEYDETIRKCNHPTRMELEESCHHLNLVLLDQNEYSTLREPLENRNVEDLINTLSKLNYIAIPNTIYQDLIGKYENPNFDYLKDSLNKMDYVAISRQDYELMVAKYEKPQLDYLKISSEKIDHIVVPLSEYNLMVTNYRNPSLSYLKEKAVLNNHILIKEDDYKNILAVSEHPTVIHLSEKASLLNKVLVDKDDFATMSRSIEKPTIDFLSTKALSMGKILVNESTHKRNEKLLSEPDSEFLTMKAKEQGLIIISEKEYSELRDQIDRPSLDVLKEKAAIFDSIIVENIEYQQLVNTTSPCPPITYEDLKVYAHQFGMELCLQKPNKLSGAERAERIDEQSINTTSSNSTTTSSMFTDALDDNIEELNRVELQNNEDYTDIISKSSTVKDATIFIPAYENIKNSAEKLGYKLVPFEKSNINLKNIEAPLFSKDNDDTSVASSIDLDHLSRKAEKYGMTLISDQEFEEYHILKDNAVNLNGGMEEMNNPLSENQNLAAKTTNTAQEGAFQNTVPHNDMDNEEVEYGPDDPTFTVRQLKKPAGDRNLILTSREKTLLSRDDNIMSQNEAVYGDDISDSFVDESQEIKNDVDIIKTQAMKYGMLCIPESNFVGASYASAQDMSDIVVLSASYYHNLMSPEDMKWNCVSNEELQAEVKKRGLQIALTTKEDKKGQATASKHEYVSHKLNNKTSTVSTKSGAKKGLAEAAATTAYEDSESHPQIEEQSHRTNHHKHHKRQQSLNSNSTSKTTHSSRNTPASRRDIVASFMSRAGSASRTASLQTLASLNEPSIIPALTQTVIGEYLFKYYPRLGPFGFESRHERFFWVHPYTLTLYWSASNPILENPANTKTKGVAILGVESVTDPNPYPTGLYHKSIVVTTETRTIKFTCPTRQRHNIWYNSLRYLLQRNMQGISLEDIADDPTDNMYSGKIFPLPGENTKSSSKRLSASRRSVSTRSLRHRVPQSRSFGNLR", "length": 2748 }, "evidence": [ { "id": "F1N1F8", "url": "https://omabrowser.org/oma/group/F1N1F8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "dynein complex binding", "id": "GO:0070840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "nuclear matrix", "id": "GO:0016363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "ciliary transition fiber", "id": "GO:0097539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097539", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "outer kinetochore", "id": "GO:0000940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000940", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "metaphase chromosome alignment", "id": "GO:0051310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051310", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010389", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" }, { "name": "ventricular system development", "id": "GO:0021591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021591", "evidence": [ { "database": "UniProtKB", "id": "F1N1F8", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1119, "end_pos": 1121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1319, "end_pos": 1321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1516, "end_pos": 1518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1532, "end_pos": 1534, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1665, "end_pos": 1667, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1754, "end_pos": 1756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2112, "end_pos": 2114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2378, "end_pos": 2380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2560, "end_pos": 2562, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2733, "end_pos": 2735, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2902, "end_pos": 2904, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3071, "end_pos": 3073, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3176, "end_pos": 3178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 794, "end_pos": 796, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" }, { "start_pos": 983, "end_pos": 985, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" }, { "id": "PF10481", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10481" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centromere protein Cenp-F N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 307, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" }, { "id": "PF10473", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10473" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centromere protein Cenp-F leucine-rich repeat-containing", "eco_id": "ECO_0000259", "start_pos": 1888, "end_pos": 2027, "start_aa": "Trp", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F8" }, { "id": "PF10490", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10490" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinetochore protein Cenp-F/LEK1 Rb protein-binding", "eco_id": "ECO_0000259", "start_pos": 3115, "end_pos": 3158, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 1119, "end_pos": 1121 }, { "start_pos": 1319, "end_pos": 1321 }, { "start_pos": 1516, "end_pos": 1518 }, { "start_pos": 1532, "end_pos": 1534 }, { "start_pos": 1665, "end_pos": 1667 }, { "start_pos": 1754, "end_pos": 1756 }, { "start_pos": 2112, "end_pos": 2114 }, { "start_pos": 2378, "end_pos": 2380 }, { "start_pos": 2560, "end_pos": 2562 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 2733, "end_pos": 2735 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 2902, "end_pos": 2904 }, { "start_pos": 3071, "end_pos": 3073 }, { "start_pos": 3176, "end_pos": 3178 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 530, "end_pos": 532 }, { "start_pos": 69, "end_pos": 71 }, { "start_pos": 794, "end_pos": 796 }, { "start_pos": 976, "end_pos": 978 }, { "start_pos": 983, "end_pos": 985 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3B4-1", "uniprot_ac": "F1N3B4", "uniprot_id": "F1N3B4_BOVIN", "mass": { "chemical_mass": 68838.0, "monoisotopic_mass": 68838.0 }, "refseq": { "ac": "NP_001414835", "name": "lysosomal cobalamin transporter ABCD4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414835" }, "gene_names": [ { "name": "ABCD4", "type": "recommended", "evidence": [ { "id": "F1N3B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ] }, { "name": "ABCD4", "type": "synonym", "evidence": [ { "id": "NP_001414835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414835" } ] } ], "protein_names": [ { "name": "ATP binding cassette subfamily D member 4", "type": "synonym", "evidence": [ { "id": "F1N3B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B4/entry#names_and_taxonomy" } ] }, { "name": "ATP-binding cassette, sub-family D (ALD), member 4", "type": "synonym", "evidence": [ { "id": "NP_001414835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414835" } ] }, { "name": "ATP-binding cassette, sub-family D, member 4", "type": "synonym", "evidence": [ { "id": "NP_001414835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414835" } ] }, { "name": "lysosomal cobalamin transporter ABCD4", "type": "synonym", "evidence": [ { "id": "NP_001414835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414835" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCD4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4", "locus": { "chromosome": "10", "start_pos": 85630970, "end_pos": 85647090, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014633", "url": "https://www.ensembl.org/id/ENSBTAG00000014633" } ] } } ], "crossref": [ { "id": "F1N3B4", "url": "https://alphafold.ebi.ac.uk/entry/F1N3B4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014633", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014633", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528646", "url": "https://www.ncbi.nlm.nih.gov/gene/528646", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KQFHDME", "url": "https://omabrowser.org/oma/group/KQFHDME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11384:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06472", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06472", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9758881", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9758881", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9758890", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9758890", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001414835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414835", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NLY3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NLY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3B4-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIRGPGPRPGGRPRLDLQFLQRFLQIQKVLFPSWSSQSALMFLTLLCVALLEQLVIYQVGLIPSQYFGVLGNKDLNGFKTLTFLSVVLIVLQSMLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRVYYTLNVLRDDVDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFRSTSWLGPVSIFGYFILGTVVNRVVMGPIVAKLVQQEKLEGDFRFKHMQIRVNAEPAAFFRAGHVEHMRTDRRLQRLLKTQRELMSKELWLYIGINMFDYLGSILSYIVIAIPIFSGVYGDLSPTELSSLVSKNAFVCMYLINCFSQLIDLCTTLSDVAGYTHRIGELQETLLDMTLKSQDGEFLDESQWDLARGPGGPATEPADTAFLLERVCICAPSSHKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWASARGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSTDDERIMRFLELAGLSSLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRVGQQLGMTFISVGHRRSLEKFHSLVLRLCGDGRWELTRIKVE", "length": 606, "header": "tr|F1N3B4-1|F1N3B4_BOVIN Isoform 1 of ATP binding cassette subfamily D member 4 OS=Bos taurus OX=9913 GN=ABCD4 PE=3 SV=1 CANONICAL=F1N3B4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NLY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLY3/entry", "sequence": { "sequence": "MAIRGPGPRPGGRPRLDLQFLQRFLQIQKVLFPSWSSQSALMFLTLLCVALLEQLVIYQVGLIPSQYFGVLGNKDLNGFKTLTFLSVVLIVLQSMLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRVYYTLNVLRDDVDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFRSTSWLGPVSIFGYFILGTVVNRVVMGPIVAKLVQQEKLEGDFRAGHVEHMRTDRRLQRLLKTQRELMSKELWLYIGINMFDYLGSILSYIVIAIPIFSGVYGDLSPTELSSLVSKNAFVCMYLINCFSQLIDLCTTLSDVAGYTHRIGELQETLLDMTLKSQDGEFLDESQWDLARGPGGPATEPADTAFLLERVCICAPSSHKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWASARGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSTDDERIMRFLELAGLSSLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRVGQQLGMTFISVGHRRSLEKFHSLVLRLCGDGRWELTRIKVE", "length": 589, "header": "tr|A0A3Q1NLY3-1|F1N3B4_BOVIN Computationally mapped isoform of ATP binding cassette subfamily D member 4 OS=Bos taurus OX=9913 GN=ABCD4 PE=3 SV=1 CANONICAL=F1N3B4-1" }, "locus": { "chromosome": "10", "start_pos": 85646931, "end_pos": 85632103, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087425.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087425.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073501.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073501.1" } ] } }, { "isoform_ac": "A0AAA9RYV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYV8/entry", "sequence": { "sequence": "MAIRGPGPRPGGRPRLDLQFLQRFLQIQKVLFPSWSSQSALMFLTLLCVALLEQLVIYQVGLIPSQYFGVLGNKDLNGFKTLTFLSVVLIVLQSMLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRVYYTLNVLRDDVDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFRRFKHMQIRVNAEPAAFFRAGHVEHMRTDRRLQRLLKTQRELMSKELWLYIGINMFDYLGSILSYIVIAIPIFSGVYGDLSPTELSSLVSKNAFVCMYLINCFSQLIDLCTTLSDVAGYTHRIGELQETLLDMTLKSQDGEFLDESQWDLARGPGGPATEPADTAFLLERVCICAPSSHKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWASARGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSTDDERIMRFLELAGLSSLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRVGQQLGMTFISVGHRRSLEKFHSLVLRLCGDGRWELTRIKVE", "length": 564, "header": "tr|A0AAA9RYV8-1|F1N3B4_BOVIN Computationally mapped isoform of ATP binding cassette subfamily D member 4 OS=Bos taurus OX=9913 GN=ABCD4 PE=3 SV=1 CANONICAL=F1N3B4-1" }, "locus": { "chromosome": "10", "start_pos": 85646931, "end_pos": 85632103, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110059.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110059.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076480.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076480.1" } ] } }, { "isoform_ac": "A0AAA9TIU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU2/entry", "sequence": { "sequence": "MAIRGPGPRPGGRPRLDLQFLQRFLQIQKVLFPSWSSQSALMFLTLLCVALLEQLVIYQVGLIPSQYFGVLGNKDLNGFKTLTFLSVVLIVLQSMLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRVYYTLNVLRDDVDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFRRAGHVEHMRTDRRLQRLLKTQRELMSKELWLYIGINMFDYLGSILSYIVIAIPIFSGVYGDLSPTELSSLVSKNAFVCMYLINCFSQLIDLCTTLSDVAGYTHRIGELQETLLDMTLKSQDGEFLDESQWDLARGPGGPATEPADTAFLLERVCICAPSSHKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWASARGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSTDDERIMRFLELAGLSSLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRVGQQLGMTFISVGHRRSLEKFHSLVLRLCGDGRWELTRIKVE", "length": 547, "header": "tr|A0AAA9TIU2-1|F1N3B4_BOVIN Computationally mapped isoform of ATP binding cassette subfamily D member 4 OS=Bos taurus OX=9913 GN=ABCD4 PE=3 SV=1 CANONICAL=F1N3B4-1" }, "locus": { "chromosome": "10", "start_pos": 85646931, "end_pos": 85632103, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112527.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112527.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098378.1" } ] } }, { "isoform_ac": "A0AAA9TQG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG4/entry", "sequence": { "sequence": "MAIRGPGPRPGGRPRLDLQFLQRFLQIQKVLFPSWSSQSALMFLTLLCVALLEQLVIYQVGLIPSQYFGVLGNKDLNGFKTLTFLSVVLIVLQSMLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRVYYTLNVLRDDVDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFRSTSWLGPVSIFGYFILGTVVNRVVMGPIVAKLVQQEKLEGDFRRPHSSQPVDLGPALRFLAASFRPGPGRRRGGGSYAPVLSGARFKHMQIRVNAEPAAFFRAGHVEHMRTDRRLQRLLKTQRELMSKELWLYIGINMFDYLGSILSYIVIAIPIFSGVYGDLSPTELSSLVSKNAFVCMYLINCFSQLIDLCTTLSDVAGYTHRIGELQETLLDMTLKSQDGEFLDESQWDLARGPGGPATEPADTAFLLERVCICAPSSHKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWASARGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSTDDERIMRFLELAGLSSLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRVGQQLGMTFISVGHRRSLEKFHSLVLRLCGDGRWELTRIKVE", "length": 648, "header": "tr|A0AAA9TQG4-1|F1N3B4_BOVIN Computationally mapped isoform of ATP binding cassette subfamily D member 4 OS=Bos taurus OX=9913 GN=ABCD4 PE=3 SV=1 CANONICAL=F1N3B4-1" }, "locus": { "chromosome": "10", "start_pos": 85646931, "end_pos": 85632103, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087641.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087641.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100825.1" } ] } }, { "isoform_ac": "F1N3B4-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B4/entry", "sequence": { "sequence": "MAIRGPGPRPGGRPRLDLQFLQRFLQIQKVLFPSWSSQSALMFLTLLCVALLEQLVIYQVGLIPSQYFGVLGNKDLNGFKTLTFLSVVLIVLQSMLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRVYYTLNVLRDDVDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFRSTSWLGPVSIFGYFILGTVVNRVVMGPIVAKLVQQEKLEGDFRFKHMQIRVNAEPAAFFRAGHVEHMRTDRRLQRLLKTQRELMSKELWLYIGINMFDYLGSILSYIVIAIPIFSGVYGDLSPTELSSLVSKNAFVCMYLINCFSQLIDLCTTLSDVAGYTHRIGELQETLLDMTLKSQDGEFLDESQWDLARGPGGPATEPADTAFLLERVCICAPSSHKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWASARGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSTDDERIMRFLELAGLSSLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRVGQQLGMTFISVGHRRSLEKFHSLVLRLCGDGRWELTRIKVE", "length": 606, "header": "tr|F1N3B4-1|F1N3B4_BOVIN Isoform 1 of ATP binding cassette subfamily D member 4 OS=Bos taurus OX=9913 GN=ABCD4 PE=3 SV=1 CANONICAL=F1N3B4-1" }, "locus": { "chromosome": "10", "start_pos": 85646931, "end_pos": 85632103, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019482.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019482.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019482.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019482.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9758881", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9758881", "resource": "Reactome", "description": "Uptake of dietary cobalamins into enterocytes" }, { "id": "R-BTA-9758890", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9758890", "resource": "Reactome", "description": "Transport of RCbl within the body" } ], "orthologs": [ { "uniprot_canonical_ac": "F1Q4Y1-1", "protein_name": "Lysosomal cobalamin transporter ABCD4", "gene_name": "abcd4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTPMKQSSVKRPKLDWKFLQRFYSILKILFPSWSNQNVRMFMTLLGVTLSVQLVIYQVGLIPSQFYRVLSERSYGKFKDLVVFAVVLILINSTLKSLDQYICSLLYVRWRKTLTEDLHHLYFKGRVYYTLNILCKDIDNPDQRISQDVERLCKQMSTMASRLLITPFTVTYYTYQCFNSAGWIGFVSIFSYFVVGTIINKILIGPIVSMLVEQEKLEGDFRFKHMQIRVNAESAAFYRASNVEHMRTDRKLQMLLSTQRSLMNKELWLYLGVNTFDYMGSILSYIVIAIPIFAGNYDHLTPGELSALISKNAFVCIYLINCFTQLIDLSTTVSDVAGYTHRIGELQEAMADIAKKQRDEYQYDPVSKAESNSDRELQSVPADTAFVLDRLCYKSPLSEELLVKDLTLSISQGTHLLVVGNTGTGKTSLLRVLNSLWEPCRGSVQMTTCFGPRGLMFLPQKAYLTDGTLRDQIIYPLKDIYPSSGSIDDERILKYLELVGLSNLLTRIGGLDTEVTWNWYDVLSPGEMQRLCFARLLYLQPKFAVLDEATSALTEEAEGQLYNACKQQGMTLISLGHRSTLEKHHDVMLRLCGGGQWELSKLKEP", "length": 604 }, "evidence": [ { "id": "F1N3B4", "url": "https://omabrowser.org/oma/group/F1N3B4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O14678-1", "protein_name": "Lysosomal cobalamin transporter ABCD4", "gene_name": "ABCD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRIKVE", "length": 606 }, "evidence": [ { "id": "F1N3B4", "url": "https://omabrowser.org/oma/group/F1N3B4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O89016-1", "protein_name": "Lysosomal cobalamin transporter ABCD4", "gene_name": "Abcd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVPGPTARAGARPRLDLQLVQRFVRIQKVFFPSWSSQNVLMFMTLLCVTLLEQLVIYQVGLIPSQYYGVLGNKDLDGFKALTLLAVTLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHHLYFRARVYYTLNVLRDDIDNPDQRISQDVERFCRQLSSVTSKLIISPFTLTYYTYQCFQSTGWLGPVSIFGYFIVGTMVNKTLMGPIVTKLVQQEKLEGDFRFKHMQIRVNAEPAAFYRAGLVEHMRTDRRLQRLLQTQRELMSRELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPTELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGELQEALLDMSRKSQDCEALGESEWDLDKTPGCPTTEPSDTAFLLDRVSILAPSSDKPLIKDLSLKICEGQSLLITGNTGTGKTSLLRVLGGLWEGMKGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSADDERIVRFLELAGLSSLVARTGGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEAESELYRIGQQLGMTFISVGHRPSLEKFHSWVLRLHGGGSWELTRIKLE", "length": 606 }, "evidence": [ { "id": "F1N3B4", "url": "https://omabrowser.org/oma/group/F1N3B4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "ABC-type vitamin B12 transporter activity", "id": "GO:0015420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015420", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "long-chain fatty acid transmembrane transporter activity", "id": "GO:0005324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005324", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cobalamin metabolic process", "id": "GO:0009235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009235", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "very long-chain fatty acid catabolic process", "id": "GO:0042760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042760", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "peroxisome organization", "id": "GO:0007031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007031", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" }, { "name": "long-chain fatty acid import into peroxisome", "id": "GO:0015910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015910", "evidence": [ { "database": "UniProtKB", "id": "F1N3B4", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" }, { "id": "PS50929", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50929" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transmembrane type-1", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 311, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B4" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 389, "end_pos": 603, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3R5-1", "uniprot_ac": "F1N3R5", "uniprot_id": "F1N3R5_BOVIN", "mass": { "chemical_mass": 35970.0, "monoisotopic_mass": 35970.0 }, "refseq": { "ac": "XP_005210408", "name": "aquaporin-7 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210408" }, "gene_names": [ { "name": "AQP7", "type": "recommended", "evidence": [ { "id": "F1N3R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ] }, { "name": "AQP7", "type": "synonym", "evidence": [ { "id": "XP_005210408", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210408" } ] } ], "protein_names": [ { "name": "Aquaporin-3", "type": "recommended", "evidence": [ { "id": "F1N3R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R5/entry#names_and_taxonomy" } ] }, { "name": "Aquaglyceroporin-3", "type": "synonym", "evidence": [ { "id": "F1N3R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R5/entry#names_and_taxonomy" } ] }, { "name": "aquaporin-7 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005210408", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210408" } ] } ], "function": [ { "annotation": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Also participates in cell permeability to H2O2 and H2O2-mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC34#function" }, { "database": "UniProtKB", "id": "ARBA00049592", "url": "https://www.uniprot.org/uniprotkb/ARBA00049592#function" }, { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AQP7", "url": "https://www.uniprot.org/uniprotkb/F1N3R5", "locus": { "chromosome": "8", "start_pos": 75137786, "end_pos": 75154391, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020105", "url": "https://www.ensembl.org/id/ENSBTAG00000020105" } ] } } ], "crossref": [ { "id": "F1N3R5", "url": "https://alphafold.ebi.ac.uk/entry/F1N3R5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020105", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020105", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00333", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00333", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615498", "url": "https://www.ncbi.nlm.nih.gov/gene/615498", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3R5", "url": "https://www.orthodb.org/?gene=F1N3R5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43829:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43829:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432030", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432030", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432047", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432047", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005210408", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210408", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29667", "url": "https://www.rhea-db.org/rhea/29667", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29675", "url": "https://www.rhea-db.org/rhea/29675", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "74375", "url": "https://www.rhea-db.org/rhea/74375", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3R5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3R5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQSDRKRRSTRVSKVVSTPTATKMQVIWQNENVREFLAEFISTYVMMVFGLGAVAHMVLGGKMGSYLAVNLGFGFGVTIGVHMAGNISGAHMNAALTFTSCALGRMSWKKFPVYVLGQFLGSFVAAATIYGLFYNAIIDFSGGKLMTTGPTATANIFATYLPDHMTLWRGFLDEVVVTGMLQLCLLAIADKGNNPTLLGTQAIVTGILVVIIGISLGMNSGYAINPSRDLPPRFFTFLAGWGSQVFRTKDWWWVPVVAPPLGAYCGAIIYLFFIGSNKRQEPQVLENPLAFEDHKISVLPKTTSHQHGVASLTPVSVYPEDRPSALYHP", "length": 330, "header": "tr|F1N3R5-1|F1N3R5_BOVIN Isoform 1 of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP7 PE=3 SV=3 CANONICAL=F1N3R5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W9/entry", "sequence": { "sequence": "MKKARDRTQGSSVFMRQMNEEECGKELCRGKGYRAKRETRRETCHGSQRGGPFWKQSGEERESQHTHVFGLGAVAHMVLGGKMGSYLAVNLGFGFGVTIGVHMAGNISGAHMNAALTFTSCALGRMSWKKFPVYVLGQFLGSFVAAATIYGLFYNAIIDFSGGKLMTTGPTATANIFATYLPDHMTLWRGFLDEVVVTGMLQLCLLAIADKGNNPTLLGTQAIVTGILVVIIGISLGMNSGYAINPSRDLPPRFFTFLAGWGSQVFRTKDWWWVPVVAPPLGAYCGAIIYLFFIGSNKRQEPQVLENPLAFEDHKISVLPKTTSHQHGVASLTPVSVYPEDRPSALYHP", "length": 349, "header": "tr|A0AAA9S9W9-1|F1N3R5_BOVIN Computationally mapped isoform of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP7 PE=3 SV=1 CANONICAL=F1N3R5-1" }, "locus": { "chromosome": "8", "start_pos": 75141158, "end_pos": 75137865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080722.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080722.1" } ] } }, { "isoform_ac": "A0AAA9TC34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC34/entry", "sequence": { "sequence": "MGAPSQWSSLWHRRKKGRDLDVQPQSLSTSLGSHVPLTPEVPAALGKSRSTRVSKVVSTPTATKMQVIWQNENVREFLAEFISTYVMMVFGLGAVAHMVLGGKMGSYLAVNLGFGFGVTIGVHMAGNISGAHMNAALTFTSCALGRMSWKKFPVYVLGQFLGSFVAAATIYGLFYNAIIDFSGGKLMTTGPTATANIFATYLPDHMTLWRGFLDEVVVTGMLQLCLLAIADKGNNPTLLGTQAIVTGILVVIIGISLGMNSGYAINPSRDLPPRFFTFLAGWGSQVFRTKDWWWVPVVAPPLGAYCGAIIYLFFIGSNKRQEPQVLENPLAFEDHKISVLPKTTSHQHGVASLTPVSVYPEDRPSALYHP", "length": 370, "header": "tr|A0AAA9TC34-1|F1N3R5_BOVIN Computationally mapped isoform of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP7 PE=3 SV=1 CANONICAL=F1N3R5-1" }, "locus": { "chromosome": "8", "start_pos": 75148368, "end_pos": 75137865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088434.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088434.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093653.1" } ] } }, { "isoform_ac": "F1N3R5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3R5/entry", "sequence": { "sequence": "MTQSDRKRRSTRVSKVVSTPTATKMQVIWQNENVREFLAEFISTYVMMVFGLGAVAHMVLGGKMGSYLAVNLGFGFGVTIGVHMAGNISGAHMNAALTFTSCALGRMSWKKFPVYVLGQFLGSFVAAATIYGLFYNAIIDFSGGKLMTTGPTATANIFATYLPDHMTLWRGFLDEVVVTGMLQLCLLAIADKGNNPTLLGTQAIVTGILVVIIGISLGMNSGYAINPSRDLPPRFFTFLAGWGSQVFRTKDWWWVPVVAPPLGAYCGAIIYLFFIGSNKRQEPQVLENPLAFEDHKISVLPKTTSHQHGVASLTPVSVYPEDRPSALYHP", "length": 330, "header": "tr|F1N3R5-1|F1N3R5_BOVIN Isoform 1 of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP7 PE=3 SV=3 CANONICAL=F1N3R5-1" }, "locus": { "chromosome": "8", "start_pos": 75152959, "end_pos": 75137865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026782.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026782.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026782.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026782.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 152, "start_aa": "Thr", "end_pos": 152, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr152", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-432030", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432030", "resource": "Reactome", "description": "Transport of glycerol from adipocytes to the liver by Aquaporins" }, { "id": "R-BTA-432047", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432047", "resource": "Reactome", "description": "Passive transport by Aquaporins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "channel activity", "id": "GO:0015267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015267", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" }, { "name": "water channel activity", "id": "GO:0015250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015250", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" }, { "name": "glycerol channel activity", "id": "GO:0015254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015254", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" }, { "name": "urea transmembrane transporter activity", "id": "GO:0015204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015204", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "water transport", "id": "GO:0006833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006833", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" }, { "name": "glycerol transmembrane transport", "id": "GO:0015793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015793", "evidence": [ { "database": "UniProtKB", "id": "F1N3R5", "url": "https://www.uniprot.org/uniprotkb/F1N3R5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29667", "name": "", "equation": "H2O(in) = H2O(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29667", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29667" } ] }, { "id": "29675", "name": "", "equation": "glycerol(in) = glycerol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29675", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29675" } ] }, { "id": "74375", "name": "", "equation": "H2O2(out) = H2O2(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "74375", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/74375" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 152 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2M3-1", "uniprot_ac": "F1N2M3", "uniprot_id": "F1N2M3_BOVIN", "mass": { "chemical_mass": 49942.0, "monoisotopic_mass": 49942.0 }, "refseq": { "ac": "XP_003586717", "name": "zinc finger and BTB domain-containing protein 26 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586717" }, "gene_names": [ { "name": "ZBTB26", "type": "recommended", "evidence": [ { "id": "F1N2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ] }, { "name": "ZBTB26", "type": "synonym", "evidence": [ { "id": "XP_003586717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586717" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain containing 26", "type": "synonym", "evidence": [ { "id": "F1N2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2M3/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 26 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_003586717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586717" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAZ5#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9TCU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU6#function" }, { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB26", "url": "https://www.uniprot.org/uniprotkb/F1N2M3", "locus": { "chromosome": "11", "start_pos": 94079533, "end_pos": 94097410, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038610", "url": "https://www.ensembl.org/id/ENSBTAG00000038610" } ] } } ], "crossref": [ { "id": "ENSBTAG00000038610", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038610", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100848248", "url": "https://www.ncbi.nlm.nih.gov/gene/100848248", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848248", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848248", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003586717", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586717", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2M3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2M3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKPKQPMESKEGCEPQSASPQSKEHQGDARGSPKQDSPCIHPSEDSMDIEDSDIQIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNYALSYTGSDNIIMAAKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQVLDAGKLAQAVLNLRNDSTCVN", "length": 441, "header": "tr|F1N2M3-1|F1N2M3_BOVIN Isoform 1 of Zinc finger and BTB domain containing 26 OS=Bos taurus OX=9913 GN=ZBTB26 PE=4 SV=3 CANONICAL=F1N2M3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAZ5/entry", "sequence": { "sequence": "MNRSAKMSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKPKQPMESKEGCEPQSASPQSKEHQGDARGSPKQDSPCIHPSEDSMDIEDSDIQIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNYALSYTGSDNIIMAAKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQVLDAGKLAQAVLNLRNDSTCVN", "length": 447, "header": "tr|A0AAA9SAZ5-1|F1N2M3_BOVIN Computationally mapped isoform of Zinc finger and BTB domain containing 26 OS=Bos taurus OX=9913 GN=ZBTB26 PE=4 SV=1 CANONICAL=F1N2M3-1" }, "locus": { "chromosome": "11", "start_pos": 94086054, "end_pos": 94084617, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092748.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092748.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079345.1" } ] } }, { "isoform_ac": "A0AAA9TCU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU6/entry", "sequence": { "sequence": "MRSFSKEIALQQDIYAVFTKKPSPWSAKMSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKPKQPMESKEGCEPQSASPQSKEHQGDARGSPKQDSPCIHPSEDSMDIEDSDIQIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNYALSYTGSDNIIMAAKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQVLDAGKLAQAVLNLRNDSTCVN", "length": 469, "header": "tr|A0AAA9TCU6-1|F1N2M3_BOVIN Computationally mapped isoform of Zinc finger and BTB domain containing 26 OS=Bos taurus OX=9913 GN=ZBTB26 PE=4 SV=1 CANONICAL=F1N2M3-1" }, "locus": { "chromosome": "11", "start_pos": 94087059, "end_pos": 94084617, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110143.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110143.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095894.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095894.1" } ] } }, { "isoform_ac": "F1N2M3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2M3/entry", "sequence": { "sequence": "MSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKPKQPMESKEGCEPQSASPQSKEHQGDARGSPKQDSPCIHPSEDSMDIEDSDIQIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNYALSYTGSDNIIMAAKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQVLDAGKLAQAVLNLRNDSTCVN", "length": 441, "header": "tr|F1N2M3-1|F1N2M3_BOVIN Isoform 1 of Zinc finger and BTB domain containing 26 OS=Bos taurus OX=9913 GN=ZBTB26 PE=4 SV=3 CANONICAL=F1N2M3-1" }, "locus": { "chromosome": "11", "start_pos": 94085939, "end_pos": 94084617, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096526.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096526.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098611.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848248", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848248", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "F1N2M3", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 97, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2M3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 273, "end_pos": 295, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 435, "end_pos": 437 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N672-1", "uniprot_ac": "F1N672", "uniprot_id": "F1N672_BOVIN", "mass": { "chemical_mass": 75706.0, "monoisotopic_mass": 75706.0 }, "refseq": { "ac": "NP_001192252", "name": "transmembrane 9 superfamily member 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192252" }, "gene_names": [ { "name": "TM9SF2", "type": "recommended", "evidence": [ { "id": "F1N672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ] }, { "name": "TM9SF2", "type": "synonym", "evidence": [ { "id": "NP_001192252", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192252" } ] } ], "protein_names": [ { "name": "Transmembrane 9 superfamily member", "type": "recommended", "evidence": [ { "id": "F1N672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N672/entry#names_and_taxonomy" } ] }, { "name": "transmembrane 9 superfamily member 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192252", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192252" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM9SF2", "url": "https://www.uniprot.org/uniprotkb/F1N672", "locus": { "chromosome": "12", "start_pos": 76395109, "end_pos": 76343402, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001589", "url": "https://www.ensembl.org/id/ENSBTAG00000001589" } ] } } ], "crossref": [ { "id": "F1N672", "url": "https://alphafold.ebi.ac.uk/entry/F1N672", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001589", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001589", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514455", "url": "https://www.ncbi.nlm.nih.gov/gene/514455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514455", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514455", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KVYYMFG", "url": "https://omabrowser.org/oma/group/KVYYMFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N672", "url": "https://www.orthodb.org/?gene=F1N672", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10766", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10766", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10766:SF111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10766:SF111", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02990", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02990", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192252", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N672-1", "url": "https://www.uniprot.org/uniprotkb/F1N672-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSARLPAPCPPRWWLLLSLLLLGAAPGPRRGAAFYLPGLAPVNFCEEEKKTDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFKKEETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYEVEDSQRFCNPGFPIGCYITDKGHAKDACVINSEFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKVAYTYSINFEEEKNIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAIHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD", "length": 661, "header": "tr|F1N672-1|F1N672_BOVIN Isoform 1 of Transmembrane 9 superfamily member OS=Bos taurus OX=9913 GN=TM9SF2 PE=1 SV=3 CANONICAL=F1N672-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD81/entry", "sequence": { "sequence": "MSARLPAPCPPRWWLLLSLLLLGAAPGPRRGAAFYLPGLAPVNFCEEEKKTDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFKKEETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYEVEDSQRFCNPGFPIGCYITDKGHAKDACVINSEFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKVAYTYSINFEEEKNIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAIHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTAHQASLSITNSRSSLKRTSIESVMPSIFSCKTVSEFTFST", "length": 679, "header": "tr|A0AAA9SD81-1|F1N672_BOVIN Computationally mapped isoform of Transmembrane 9 superfamily member OS=Bos taurus OX=9913 GN=TM9SF2 PE=1 SV=1 CANONICAL=F1N672-1" }, "locus": { "chromosome": "12", "start_pos": 76393289, "end_pos": 76343532, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121242.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121242.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083365.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083365.1" } ] } }, { "isoform_ac": "F1N672-1", "url": "https://www.uniprot.org/uniprotkb/F1N672/entry", "sequence": { "sequence": "MSARLPAPCPPRWWLLLSLLLLGAAPGPRRGAAFYLPGLAPVNFCEEEKKTDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFKKEETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYEVEDSQRFCNPGFPIGCYITDKGHAKDACVINSEFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKVAYTYSINFEEEKNIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAIHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD", "length": 661, "header": "tr|F1N672-1|F1N672_BOVIN Isoform 1 of Transmembrane 9 superfamily member OS=Bos taurus OX=9913 GN=TM9SF2 PE=1 SV=3 CANONICAL=F1N672-1" }, "locus": { "chromosome": "12", "start_pos": 76394317, "end_pos": 76343532, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002080.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002080.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002080.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002080.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514455", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514455", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P58021-1", "protein_name": "Transmembrane 9 superfamily member 2", "gene_name": "Tm9sf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSRPPASPPAQGSRLLLLSLLLLGTVPGPRPGSAFYLPGLAPVNFCAEEKSNECKADIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYNTEKAEDKQKLDFLKKSMLLNYQHHWIVDNMPVTWCYEVEDSQKFCNPGFPIGCYITDKGHAKDACVISSEFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPAMDISNKASGEIKIAYTYSISFEEEKNIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAIHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD", "length": 662 }, "evidence": [ { "id": "F1N672", "url": "https://omabrowser.org/oma/group/F1N672/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q04562-1", "protein_name": "Transmembrane 9 superfamily member 2", "gene_name": "TMN2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKRGVWLLIYCYATLTKGFSLPGLSPTTYHSGDEIPLLVNRLTPSIYFQHQDEEGNDVSGDKEHFLYSYDYYNKRFHFCRPEHVEKQPESLGSVIFGDRIYNSPFQLNMLEEKECVALCKSTIPGKDAKFINTLIKSGFFQNWLVDGLPAARKAYDSRTKTNYYGTGFELGFTDVKQTVDGKAVPSTMEELTSEASNEDVILDARLPKNVKPNLVKTVELPYFVNHFDIEVEFHDRGNDNYRVVGVIVNPVSIERSSPGACSTTGKPLILDEDKDNEVYFTYSVKFVASDTVWATRWDKYLHIYDPQIQWFSLINFSVIVILLSSVVMHSLLRALKSDLARYNELNLDNEFHEDSGWKLGHGDVFRTPSKSMLLSILVGSGMQLFLMVMCSIFFAAVGLVSPVSRGSLPTVMFVLYALFGFVGSYASMGVYKFFRGPYWKANMILTPILLPGAIFLLIVIMNFFLLFAHSSGVIPARSLFFIILLWFLVSVPLSFAGSIVAHKQCNWDEHPTKTNQIARQIPYQPWYLRTAQATLIAGIFSFGSIAVELYFIYSSLWFNKIFYMFGFLLFSFLLLTLTTSLVTILITYYSLCLENWLWQWRSFIIGGLGCSIYTFIHSILFTKFKLGGVITVVLYLGYSLIISALCCVVTGAIGFFSSMFFIRKIYSAIKVE", "length": 672 }, "evidence": [ { "id": "F1N672", "url": "https://omabrowser.org/oma/group/F1N672/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q66HG5-1", "protein_name": "Transmembrane 9 superfamily member 2", "gene_name": "Tm9sf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSRPPASLPARGPRLLLLSLLLLGTVPGPRPGSAFYLPGLAPVNFCTEEKKSNECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFNKEETCKLVCTKTYHTEKAEDKQKLDFLKKSMLLNYQHHWIVDNMPVTWCYEVEDNQKFCNPGFPIGCYITDKGHAKDACVISSEFHERDTFYIFNHVDIKIQYHVVETGSMGARLVAAKLEPKSFRHTHIDKPDCSGPAMDISNKASGEIKIAYTYSISFEEEKNIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLVYAIHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD", "length": 663 }, "evidence": [ { "id": "F1N672", "url": "https://omabrowser.org/oma/group/F1N672/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99805-1", "protein_name": "Transmembrane 9 superfamily member 2", "gene_name": "TM9SF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPIGCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYTYSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD", "length": 663 }, "evidence": [ { "id": "F1N672", "url": "https://omabrowser.org/oma/group/F1N672/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VIK1-1", "protein_name": "Transmembrane 9 superfamily member", "gene_name": "TM9SF2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MILLSGLLPLLGVVLLHLATPTQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVNRLNTEESVIPYEYHHFDFCLGEEQNSPVENLGQVVFGERIRPGPYKIQFLENQQCATTCVKTYKGDDPASNRRMMVLKKGISLNYQHHWIVDNMPVTWCYPLENGKQYCGIGFPMGCLVRSDGEGCPINSIYNQPMHYYPFNHVDLEITYHSGQSEDWGIQFGNSGRIISVKVTPKSIKHTDKENPNCLSTEPLAISENSLKAGEQLEIVYTYSVKFVKNDSIKWSSRWDYILESMPHTNIQWFSILNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSGEDAQEEFGWKLVHGDVFRPPRKGMLLSVFLGSGVQVLVMAMITLAFACLGFLSPANRGALMTCSMVLFVSLGTPAGYVSARIYKSFGGLKWKSNVILTSIVCPGVVFSLFFVMNLVLWGENSSGAVPFSTLIALLALWFGVSVPLTFVGAYFGFRKRALEHPVRTNQIPRQIPDQSIYTQPIPGIVMGGVLPFGCIFIQLFFILSSLWSSQIYYMFGFLFLVFVILVITCSETTILLCYFHLCAEDYHWWWRSFLTSGFTAVYLFIYCCHYFVTKLSIKDSASTFLYFGYTAIMVFLFFLLTGTIGFFACFWFIRKIYSVVKVD", "length": 659 }, "evidence": [ { "id": "F1N672", "url": "https://omabrowser.org/oma/group/F1N672/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "glycosphingolipid biosynthetic process", "id": "GO:0006688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006688", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" }, { "name": "ceramide metabolic process", "id": "GO:0006672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006672", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" }, { "name": "regulation of heparan sulfate proteoglycan biosynthetic process", "id": "GO:0010908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010908", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "F1N672", "url": "https://www.uniprot.org/uniprotkb/F1N672" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5P7-1", "uniprot_ac": "F1N5P7", "uniprot_id": "F1N5P7_BOVIN", "mass": { "chemical_mass": 114585.0, "monoisotopic_mass": 114585.0 }, "refseq": { "ac": "NP_001192724", "name": "protein FAM83B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192724" }, "gene_names": [ { "name": "FAM83B", "type": "recommended", "evidence": [ { "id": "F1N5P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ] }, { "name": "FAM83B", "type": "synonym", "evidence": [ { "id": "NP_001192724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192724" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 83 member B", "type": "synonym", "evidence": [ { "id": "F1N5P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P7/entry#names_and_taxonomy" } ] }, { "name": "protein FAM83B", "type": "synonym", "evidence": [ { "id": "NP_001192724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192724" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM83B", "url": "https://www.uniprot.org/uniprotkb/F1N5P7", "locus": { "chromosome": "23", "start_pos": 5456524, "end_pos": 5552818, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016058", "url": "https://www.ensembl.org/id/ENSBTAG00000016058" } ] } } ], "crossref": [ { "id": "F1N5P7", "url": "https://alphafold.ebi.ac.uk/entry/F1N5P7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016058", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016058", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09182", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09182", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540231", "url": "https://www.ncbi.nlm.nih.gov/gene/540231", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540231", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540231", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYKPHFI", "url": "https://omabrowser.org/oma/group/GYKPHFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N5P7", "url": "https://www.orthodb.org/?gene=F1N5P7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16181:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16181:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-177929", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177929", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5P7-1", "url": "https://www.uniprot.org/uniprotkb/F1N5P7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSSMLSSLNDECKSDNYIEPHYKEWYRVAVDTLIEHGLDAYKEFLAKERVSDFLAEEEINYILNNVQKVAQSTSHGPDNSCDDASSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIELLFHPPRAQLLTIKETVRKMIKEARKVIALAMDIFTDVDIFKEIVEASTRGISVYILLDESKFSHFLSMTEKQGCQVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMFGSYSYMWSFEKAHLSMVQVITGQLVESFDEEFRTLYARSCVPSSFAPEESVRVNRGKALWENGTYQRSVSSLASVSSQRNLFGRQDSIHKLDSSYFKNRGIYTRNEHDKYNIRNHTYKPHFVPNFNGPIRQHQHSQLNENWKRHSYAGEQPETTPYLLLNRALNRNVNAPGNWKKPSDSLSVTSSSRGGYGGRQHTPAQSFADRLAQRKTTNLPERNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEAAPDSNGSAPADRFEGYEGHENLKASALYTHSRLRSSLVFKPTLPEQQEANSCTTDSSNSTVVGSQGSDTPKKIPDTPTGAQLMTDKPPEEATPKSSLHPEAPKMHTLQVPESHPPALNPTTNGPTESNNYLYTTLCANKQTENPKNQQNENLLKRRSFPFFDHSKANMDHGNSKHYVYSTLTRNPVRQPEKLKEDLLKSSKSMHSMTHGVEEEEEGEEEVPKGDPPSGTGNKSISMAALLDVNKEEPNKEVTSKKEVKGSPSFLKKGSQKLRSLLSLAPEKKDNLSKNKAPAFYRMCSSSDTLISEAEENQKQKKSEPKNDSSPRRKHSSSSNSPGSIHKSKEDVAVHSPKRIHSPSDESNKTIASSGPAESKFSERAGDASAPRFNTEQIQYQDSKEIKAVVAPERKPTSSPRAKPNDELLRTHSIERRVYSRFEPFCKIESSIQPTSNMPNSSTHRPEVKSSTMGNSYGRSSPMLNYNTGVYHSFQPNENKFRGFMQKFGNFIHKNK", "length": 1014, "header": "tr|F1N5P7-1|F1N5P7_BOVIN Isoform 1 of Family with sequence similarity 83 member B OS=Bos taurus OX=9913 GN=FAM83B PE=3 SV=1 CANONICAL=F1N5P7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK1/entry", "sequence": { "sequence": "MESSSMLSSLNDECKSDNYIEPHYKEWYRVAVDTLIEHGLDAYKEFLAKERVSDFLAEEEINYILNNVQKVAQSTSHGPDNSCDDASSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIELLFHPPRAQLLTIKETVRKMIKEARKESSLPCLHFKRKEVIALAMDIFTDVDIFKEIVEASTRGISVYILLDESKFSHFLSMTEKQGCQVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMFGSYSYMWSFEKAHLSMVQVITGQLVESFDEEFRTLYARSCVPSSFAPEESVRVNRGKALWENGTYQRSVSSLASVSSQRNLFGRQDSIHKLDSSYFKNRGIYTRNEHDKYNIRNHTYKPHFVPNFNGPIRQHQHSQLNENWKRHSYAGEQPETTPYLLLNRALNRNVNAPGNWKKPSDSLSVTSSSRGGYGGRQHTPAQSFADRLAQRKTTNLPERNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEAAPDSNGSAPADRFEGYEGHENLKASALYTHSRLRSSLVFKPTLPEQQEANSCTTDSSNSTVVGSQGSDTPKKIPDTPTGAQLMTDKPPEEATPKSSLHPEAPKMHTLQVPESHPPALNPTTNGPTESNNYLYTTLCANKQTENPKNQQNENLLKRRSFPFFDHSKANMDHGNSKHYVYSTLTRNPVRQPEKLKEDLLKSSKSMHSMTHGVEEEEEGEEEVPKGDPPSGTGNKSISMAALLDVNKEEPNKEVTSKKEVKGSPSFLKKGSQKLRSLLSLAPEKKDNLSKNKAPAFYRMCSSSDTLISEAEENQKQKKSEPKNDSSPRRKHSSSSNSPGSIHKSKEDVAVHSPKRIHSPSDESNKTIASSGPAESKFSERAGDASAPRFNTEQIQYQDSKEIKAVVAPERKPTSSPRAKPNDELLRTHSIERRVYSRFEPFCKIESSIQPTSNMPNSSTHRPEVKSSTMGNSYGRSSPMLNYNTGVYHSFQPNENKFRGFMQKFGNFIHKNK", "length": 1027, "header": "tr|A0AAA9SGK1-1|F1N5P7_BOVIN Computationally mapped isoform of Family with sequence similarity 83 member B OS=Bos taurus OX=9913 GN=FAM83B PE=3 SV=1 CANONICAL=F1N5P7-1" }, "locus": { "chromosome": "23", "start_pos": 5531408, "end_pos": 5457115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122464.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122464.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082823.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082823.1" } ] } }, { "isoform_ac": "F1N5P7-1", "url": "https://www.uniprot.org/uniprotkb/F1N5P7/entry", "sequence": { "sequence": "MESSSMLSSLNDECKSDNYIEPHYKEWYRVAVDTLIEHGLDAYKEFLAKERVSDFLAEEEINYILNNVQKVAQSTSHGPDNSCDDASSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIELLFHPPRAQLLTIKETVRKMIKEARKVIALAMDIFTDVDIFKEIVEASTRGISVYILLDESKFSHFLSMTEKQGCQVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMFGSYSYMWSFEKAHLSMVQVITGQLVESFDEEFRTLYARSCVPSSFAPEESVRVNRGKALWENGTYQRSVSSLASVSSQRNLFGRQDSIHKLDSSYFKNRGIYTRNEHDKYNIRNHTYKPHFVPNFNGPIRQHQHSQLNENWKRHSYAGEQPETTPYLLLNRALNRNVNAPGNWKKPSDSLSVTSSSRGGYGGRQHTPAQSFADRLAQRKTTNLPERNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEAAPDSNGSAPADRFEGYEGHENLKASALYTHSRLRSSLVFKPTLPEQQEANSCTTDSSNSTVVGSQGSDTPKKIPDTPTGAQLMTDKPPEEATPKSSLHPEAPKMHTLQVPESHPPALNPTTNGPTESNNYLYTTLCANKQTENPKNQQNENLLKRRSFPFFDHSKANMDHGNSKHYVYSTLTRNPVRQPEKLKEDLLKSSKSMHSMTHGVEEEEEGEEEVPKGDPPSGTGNKSISMAALLDVNKEEPNKEVTSKKEVKGSPSFLKKGSQKLRSLLSLAPEKKDNLSKNKAPAFYRMCSSSDTLISEAEENQKQKKSEPKNDSSPRRKHSSSSNSPGSIHKSKEDVAVHSPKRIHSPSDESNKTIASSGPAESKFSERAGDASAPRFNTEQIQYQDSKEIKAVVAPERKPTSSPRAKPNDELLRTHSIERRVYSRFEPFCKIESSIQPTSNMPNSSTHRPEVKSSTMGNSYGRSSPMLNYNTGVYHSFQPNENKFRGFMQKFGNFIHKNK", "length": 1014, "header": "tr|F1N5P7-1|F1N5P7_BOVIN Isoform 1 of Family with sequence similarity 83 member B OS=Bos taurus OX=9913 GN=FAM83B PE=3 SV=1 CANONICAL=F1N5P7-1" }, "locus": { "chromosome": "23", "start_pos": 5531408, "end_pos": 5457115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021370.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021370.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021370.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021370.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 630, "start_aa": "Thr", "end_pos": 630, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr630", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540231", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540231", "resource": "KEGG Pathway" }, { "id": "R-BTA-177929", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177929", "resource": "Reactome", "description": "Signaling by EGFR" }, { "id": "R-BTA-9696264", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "resource": "Reactome", "description": "RND3 GTPase cycle" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" }, { "id": "R-BTA-9696273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "resource": "Reactome", "description": "RND1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I737-1", "protein_name": "Protein FAM83B", "gene_name": "Fam83b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METSSMLSSLNDECRSDNYIEPHYKEWYRVAVDALIEHGIEAYQEFLVKERVSDFLAEEEINYILKNVQKFAQHTERGSDNSYDDASSSGTYWPMQSDVEAPNLDLGWPYVMPGLLGSTHIDLLFHPPRAHLLTIKETIRKMIKDARKVIAIVMDIFTDVDIFKEIIEASTRGISVYILLDESNFNHFLTMTEKQGCQIQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGHLVELFDEEFRTLYARSCVPSSFAQEESVRVKPGKALWENGIYQRSISSLASVSSQRNLFGRQDQIHKIDSSYFKGRGMYALNEHDKLSMRNHGYKPHFIPNFNGPNAVRHFQPSQINENWKRHSYAGEQPETTPYLLLNRALNRTNNAPGHWRRPSDSLSVASSLRGGQANQTNIPAQSFADRLAQRKTTNLAERNSNVRRSFNGTDNHIRSLQQRMPTLENTTKSFLRSWRIDSYLNDNSEVPPDSNGSTLGDRFEGYDNHESVKANALYTHSRLRSSFVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSDTHSEVQESSTSALPLTEKPLPESIPKLPTQSEVPKMHSLQVPEKPPAILNQTTNGRAELNNCIYTNLCVNKQLENTKNQPSENLLKRRSFPSFDHSKVNLEHGNTKNYVYSTLTRNRVRQPAKPKEEVLKTSKSMHNVTHSTDEEEEEAIKRHPPTSSATKSISIAALLDVNKEDPNKELTSKKDVKGSPSFLKKGSQKLRSLLSLTPEKRENLSKNKAPAFYRMCSSSDTLVSEGEENQKPKKSEPRVDSSPRRKRSSSSNSQGSIHKSKEDIAVSTSPGINSQAEESRRTAPSPSPVQRRLSERAGDASAPRFNTEQIQYRDSKETSAVIAPQRRSTSSPVPKSSELLRSHSTNQRVYSRFEPFCKIESSIQPASSMTNTHVNRPEVKPTAMGSSYGRSSPMLNYKTGAYHSYSPNENKFRGFMQKFGNFIHKNK", "length": 1012 }, "evidence": [ { "id": "F1N5P7", "url": "https://omabrowser.org/oma/group/F1N5P7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XDH4-1", "protein_name": "Family with sequence similarity 83 member B", "gene_name": "FAM83B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "METSSLLSSLHDECRSDNYIEPHYKEWYRVAIDALIEGGLEAYKEFLSKERCSEFLADEEIDYILNNVHKLPQNTVYSSNNAIDDTSSSGTYWPIESDVEAPNLDLGWPYLMPGISGGTNIDLLFHPPRAQPYTIKETIRKMIRDARKVIAIVMDMFTDVDIFREIVEASTRGIAVYLLLDESNFGHFLKMTEKQGCQVQRLRNMRVRTVKGQDYYSKTGAKFHGKMEQKFLLVDCKKVVYGSYSFMWSFEKTNLSMVQVITGQLVESFDEEFRTLYARSSVPSSFAPELVRVNSRRTLWHNDTYQHSVSSLASVSSQRNLFGRQDKIHKLDPVYLKARGRFAVNEIDKFGLRNQSFNKQPFHPSFNMQNPIQQYQPSEKNEHWKRHSYAGEKPERTPYLLLNRAINRASNPSNTWKMPSDSLSIVSSLRGGYANNYNTPQQSFADQFSRPKVNLAERNSIVRRSFNGTDNQIRHLQQRMPTLEHTTKSFLRNWRIKSYLNDQSDYPVESNGSALGDRYDGYDTTENIKAHALYSHSRLRSSLVFQPTLPEQQEVSSCASSSNSTIIGSEGSATPKGTSNHAPSLENGTDNTSEELSTNASPKSEAPKNHKIQMAENIKPIVNSDALGDQSVYLYTTLCADKHAENMKNLQNENMLKRRSFPMFNSKSILDPHADKHTSSYVYSTLTRHRLKQPVSPKIPEDTLKNSKSLHSMANHLPQEERNLKGELKSPTATKAISMAVLAEAIKEESGKDCTSKKESKNSPSFLKKGSQKLRSLLNLTPDKKEILSKNKGPAFYRMCSSSDTLVSEEENQKPKISENKTDSSPRRKRNTSNSQGSLNRSKEDVTSSPSKSPKSPKSPKPQKPPSDESNKKCPVLCPLETKFIETAGDASTPRFNTEQIQYQDVKEITTNAAPESAPVCALQRATSMTPQLASSKHQEDLRSRSSERRVYSRFEPFYKMENASQLAGNTLNSSSHLSDMKSKTLGNNYGRSNHLVSYNSTAYHPFQPNENKLRGFMQKFGNFLHKNK", "length": 1029 }, "evidence": [ { "id": "F1N5P7", "url": "https://omabrowser.org/oma/group/F1N5P7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZF70-1", "protein_name": "Family with sequence similarity 83, member B", "gene_name": "Fam83b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METSSMLSSLNDECRSDNYVEPHYKEWYRVAVDTLIEHGLEAYQEFLVKERVSDFLAEEEINYILKNVQKIAQNTEHGSDSSCDDGSSSGTYWPMQSDVEAPNLDLGWPCVMPGLLGSTHIDLLFHPPRAHLLTIKETVRKMIKDARKVVAIVMDVFTDVDIFKEIVEASTRGISVYILLDESNFNHFLTMTEKQGCQIQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGHLVELFDEEFRTLYARSSVPSCFAQEESTRVKPGKALWENGIYQRSISSLASVSSQRNLFGRQDQIHKLDSSYFKGRGIYPLNEQDKHGMRNHGYKPHFVPNFNGPSAIRHFQPSQINENWKRHSYAGEQSETTPYLLLNRAMNRTNNAPGRWRRPSDSLSVASSLRGGQGSQQNIPAQSFADRLAQRKTTNLAERNSNVRRSFNGTDNHIRFIQQRMPTLENTTKSFLRSWRIESYLNDNSEAPPDSNGSTLGDRFEGYDNPETVKANAVYTHSRLRSSFVFKPTLPEQKEVNSCTTGSSNSTIIGSQGRDTPKELPESSTNAPPPLTEKPLPESIPKLPTQSEEPKTHSLRVPEKQPEVLNQRTNGRAELNNCIYTKLCVNKPMENAKNQPSDNLLKRRSFPSFDHSKVNLDHGNSKNYVYSTLTRNRIRQPEKPKEDVLKSSKSLHNVTHSTDEDDDEVTKRDPPSASAKSISIAALLDVNKEEPNKELNSKKEGKASPSFLKKGSQKLRSLLSLTPEKRENLAKNKAPAFYRMCSSSDTLVSEGEENQKPKKSEPKGDASPRRKRSSLSNSQGSIHKSKEDIAVSTSPGISSQVEETRIAPSPRPAERRLSERAGDASAPRFNTEQIQYRDSKEINAVMTPARRPTSSPVLKPSELLRSHSTNQRVYSRFEPFCKIESSIQPASSVTHVNRPEVKSTTMGSYGRSSPMLNYKTGAYQSYSPNENKFRGFMQKFGNFIHKNK", "length": 1008 }, "evidence": [ { "id": "F1N5P7", "url": "https://omabrowser.org/oma/group/F1N5P7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RZW2-1", "protein_name": "Family with sequence similarity 83 member B", "gene_name": "FAM83B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METSSMLSSLNDECKSDNYIEPHYKEWYRVAVDTLIEHGLDAYQEFLATERVSDFLAEEEIAYILKNVQKVAQSTAHGNDNSYDDTSSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIDLLFHPPRAQLLTIKETIRKMIKEARKVIALVMDIFTDVDIFKEIVEASTRGISVYILLDESNFSHFLTMTEKQGCQVQRLRNIRVRTVKGQDYLSKTGAKFHGKLEQKFLLIDCQKVMYGSYSYMWSFEKAHLSMVQLITGQLVESFDEEFRTLYARSCVPSSFAQEEAARVKRGKAFWENGTYQRSVSSFASVSSQRNLFGRQDKIHHLESSYFKNRGMYPLNEHDKYNIRNLGYKPHFVPNFNGPNPVRPLHPSQMNANWKRHSYAGEQPETAPYLLLNRALNRTGNAPGHWKRPSDSLSVTSSSRGGLAGRQNTPAQSFADRLAQRKTTNLAERNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEAAPDSNGSALGDRFEGYDGPENVKASALYNHSRLRSSLVFKPTLPEQQEVNSCTTDSSNSTVIGSQGSDTPKKVIDAPTGAQHQTDKPSQELTPRVPLQSEAPKMHTLQIPESHPAALHPNTNGPTESNNYLYTTLCVNKQTENLKNQQNENLLKRRSFPFFDHSKANLDHGNSKHYVYSTLTRNRGRQPEKPKEDLLKSSKSMHNVTRGVEEEEEDVVKREPPSATTTKSISIAALLDVNKEEPNRELTPKKEVKGSPSFLKKGSQKLRSLLSLAPEKKENLSKNKAPAFYRMCSSSDTLVSEAEENQKQKKSEPKIDSSPRRKCSSSSNSQGSIHKSKEDVAVPSSQGVQSPSDENSQVMPSSSPVESKFLERAGDASAPRFNTEQIQYQDSKEIQAVVPERKPASPRRKPNDELLRTHSIDRRVYSRFEPFCKIESSIQPTSSKPNTSTHRPEIKSTTVGNSYGRSSPMLNYNTGVYHSYQPNENKFRGFMQKFGNFIHKNK", "length": 1011 }, "evidence": [ { "id": "F1N5P7", "url": "https://omabrowser.org/oma/group/F1N5P7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q0VBM2-1", "protein_name": "Protein FAM83B", "gene_name": "Fam83b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASSMLSSLNDECRSDNYVEPHYKEWYRVAVDTLIEHGLEAYQEFLIKERVSDFLAEEEINYILKNVQKIAQNTEHGSDSSCDDGSSSGTYWPMQSDVEAPNLDLGWPYVMPGLLGSTHIDLLFHPPRAHLLTIKETIRKMIKEARKVVAIVMDVFTDVDIFKEIVEASTRGISVYILLDESNFSHFLTMTEKQGCQIQRLRNIRIRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGHLVELFDEEFRTLYARSSVPSSFAQEESVRAKPGKALWENGIYQRSISSLASVSSQRNLFGRQDQIHKLDSSYFKGRGIYPLNDQDKHSMRNHGYKPHFVPNFNGPSTIRHFQPSQLNENWKRHSYAGEQPETTPYLLLNRAMNRTNNAPGRWRRPSDSLSVASSLRGGQGSQQNIPAQSFADRLAQRKTTNLAERNSNVRRSFNGTDNHIRFIQQRMPTLENTTKSFLRSWRIESYLNDNSEVPPDSNGSTLGDRFEGYENPEAVKANALYTHSRLRSSFVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSDTPNEVPDTSTNAPPLTEKPLPEPSSKLPTQQEEPKMHNLQVPEKQPEALNQRTNGRAELNNCIYTNLCVNKQRENTENQQNDNLLKRRSFPSFDHSKVNLEHGNSKNYVYSTLTRNRIRQPEKPKEVVLKSSKSMHNVTHSAEEDDDEVIERDPPSASATKSISIAALLDVNKEEPNKEPNSKKEGKASPSFLKKGSQKLRSLLSLTPEKRESLAKNKAPAFYRMCSSSDTLVSEGEENQKPKKSEPKVDSSPRRKRSSSSNSQGSIHKSKEDIAVSASPGISSQAEESRRIAPSPRPVERRLSERAGDASAPRFNTEQIQYRDSKEISSLMTPARRPTPSPVLKPNELLRSHSTNQRVYSRFEPFCKIESSIQPASSVTNTHVNRPEVKSSTMGTAYGRSSPMLNYKTGAYHSYAPNENKFRGFMQKFGNFIHKNK", "length": 1012 }, "evidence": [ { "id": "F1N5P7", "url": "https://omabrowser.org/oma/group/F1N5P7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T0W9-1", "protein_name": "Protein FAM83B", "gene_name": "FAM83B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METSSMLSSLNDECKSDNYIEPHYKEWYRVAIDILIEHGLEAYQEFLVQERVSDFLAEEEINYILKNVQKVAQSTAHGTDDSCDDTLSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIDLLFHPPRAHLLTIKETIRKMIKEARKVIALVMDIFTDVDIFKEIVEASTRGVSVYILLDESNFNHFLNMTEKQGCSVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGQLVESFDEEFRTLYARSCVPSSFAQEESARVKHGKALWENGTYQHSVSSLASVSSQRNLFGRQDKIHKLDSSYFKNRGIYTLNEHDKYNIRSHGYKPHFVPNFNGPNAIRQFQPNQINENWKRHSYAGEQPETVPYLLLNRALNRTNNPPGNWKKPSDSLSVASSSREGYVSHHNTPAQSFANRLAQRKTTNLADRNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEATPDSNGSALGDRFEGYDNPENLKANALYTHSRLRSSLVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSETPKEVPDTPTNVQHLTDKPLPESIPKLPLQSEAPKMHTLQVPENHSVALNQTTNGHTESNNYIYKTLGVNKQTENLKNQQTENLLKRRSFPLFDNSKANLDPGNSKHYVYSTLTRNRVRQPEKPKEDLLKSSKSMHNVTHNLEEDEEEVTKRNSPSGTTTKSVSIAALLDVNKEESNKELASKKEVKGSPSFLKKGSQKLRSLLSLTPDKKENLSKNKAPAFYRLCSSSDTLVSEGEENQKPKKSDTKVDSSPRRKHSSSSNSQGSIHKSKEDVTVSPSQEINAPPDENKRTPSPGPVESKFLERAGDASAPRFNTEQIQYRDSREINAVVTPERRPTSSPRPTSSELLRSHSTDRRVYSRFEPFCKIESSIQPTSNMPNTSINRPEIKSATMGNSYGRSSPLLNYNTGVYRSYQPNENKFRGFMQKFGNFIHKNK", "length": 1011 }, "evidence": [ { "id": "F1N5P7", "url": "https://omabrowser.org/oma/group/F1N5P7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" }, { "name": "epidermal growth factor receptor binding", "id": "GO:0005154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005154", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase regulatory subunit binding", "id": "GO:0036312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036312", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase catalytic subunit binding", "id": "GO:0036313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036313", "evidence": [ { "database": "UniProtKB", "id": "F1N5P7", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 563, "end_pos": 565, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 789, "end_pos": 791, "annotation": "n_glycosylation_sequon" }, { "start_pos": 825, "end_pos": 827, "annotation": "n_glycosylation_sequon" }, { "start_pos": 866, "end_pos": 868, "annotation": "n_glycosylation_sequon" }, { "start_pos": 958, "end_pos": 960, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P7" }, { "id": "PF07894", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07894" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Scaffolding anchor of CK1", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 281, "start_aa": "Glu", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 630 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 563, "end_pos": 565 }, { "start_pos": 736, "end_pos": 738 }, { "start_pos": 789, "end_pos": 791 }, { "start_pos": 825, "end_pos": 827 }, { "start_pos": 866, "end_pos": 868 }, { "start_pos": 958, "end_pos": 960 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N242-1", "uniprot_ac": "F1N242", "uniprot_id": "F1N242_BOVIN", "mass": { "chemical_mass": 81170.0, "monoisotopic_mass": 81170.0 }, "refseq": {}, "gene_names": [ { "name": "LMBRD2", "type": "recommended", "evidence": [ { "id": "F1N242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N242" } ] } ], "protein_names": [ { "name": "LMBR1 domain containing 2", "type": "synonym", "evidence": [ { "id": "F1N242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N242/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N242", "url": "https://www.uniprot.org/uniprotkb/F1N242" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LMBRD2", "url": "https://www.uniprot.org/uniprotkb/F1N242", "locus": { "chromosome": "20", "start_pos": 38147661, "end_pos": 38088739, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020142", "url": "https://www.ensembl.org/id/ENSBTAG00000020142" } ] } } ], "crossref": [ { "id": "F1N242", "url": "https://alphafold.ebi.ac.uk/entry/F1N242", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020142", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020142", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510014", "url": "https://www.ncbi.nlm.nih.gov/gene/510014", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510014", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510014", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N242", "url": "https://www.orthodb.org/?gene=F1N242", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21355:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21355:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T184", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T184", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T184-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T184-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N242", "url": "https://www.uniprot.org/uniprotkb/F1N242", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N242-1", "url": "https://www.uniprot.org/uniprotkb/F1N242-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIVGTLLAWYLCFLIVFILPLDVSTTIYNRCKHAAANSSPPEGSNMTGLYATATSVPSQHLCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPHLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEETLEDVMEEVRKVNESIKYNHPLRKCVDTILKKCPIDYQEKMGRNMDDYEDFDEKHNTYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATCQFVHTFQSPEPENRFIQYFYNPTVEWYWECLLRPWFYRILAVVLSIFSVIVVWSECTFFSTRPVLSLFAVFIQLAEKTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHQNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDNDMTSDLVDEGKELIRREKRKRQRQEEGENRRREWKERYGHSREDSTRNRNVHIDPKESNFSEMSTNRSTSKYTRANNRTERDRIELLQDAEPLDFNAETFTDDPLESESGSQTASSMKSKVMFACLAISPQSV", "length": 698, "header": "tr|F1N242-1|F1N242_BOVIN Isoform 1 of LMBR1 domain containing 2 OS=Bos taurus OX=9913 GN=LMBRD2 PE=3 SV=4 CANONICAL=F1N242-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB4/entry", "sequence": { "sequence": "MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIVGTLLAWYLCFLIVFILPLDVSTTIYNRCKHAAANSSPPEGSNMTGLYATATSVPSQHLCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPHLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEETLEDVMEEVRKVNESIKYNHPLRKCVDTILKKCPIDYQEKMGRNMDDYEDFDEKHNTYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATCQFVHTFQSPEPENRFIQYFYNPTVEWYWECLLRPWFYRILAVVLSIFSVIVVWSECTFFSTRPVLSLFAVFIQLAEKTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHQNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDNDMTSDLVDEGKELIRREKRKRQRQEEGENRRREWKERYGHSREDSTRNRNVHIDPKESNFSEMSTNRSTSKYTRANNRTERDRIELLQDAEPLDFNAETFTDDPLESESGRFYHETQMLL", "length": 685, "header": "tr|A0AAA9SHB4-1|F1N242_BOVIN Computationally mapped isoform of LMBR1 domain containing 2 OS=Bos taurus OX=9913 GN=LMBRD2 PE=3 SV=1 CANONICAL=F1N242-1" }, "locus": { "chromosome": "20", "start_pos": 38137345, "end_pos": 38105482, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131936.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131936.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081891.1" } ] } }, { "isoform_ac": "A0AAA9T184-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T184/entry", "sequence": { "sequence": "MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIVGTLLAWYLCFLIVFILPLDVSTTIYNRCKHAAANSSPPEGSNMTGLYATATSVPSQHLCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPHLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEETLEDVMEEVRKVNESIKYNHPLRKCVDTILKKCPIDYQEKMGRNMDDYEDFDEKHNTYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATCQFVHTFQSPEPENRFIQYFYNPTVEWYWECLLRPWFYRILAVVLSIFSVIVVWSECTFFSTRPVLSLFAVFIQLAEKTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHQNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDNDMTSDLVDEGKELIRREKRKRQRQEEGENRRREWKERYGHSREDSTRNRNVHIDPKESNFSEMSTNRSTSKYTRANNRTERDRIELLQDAEPLDFNAETFTDDPLESESGRYQPGGRYLSMSRSRIFDDV", "length": 695, "header": "tr|A0AAA9T184-1|F1N242_BOVIN Computationally mapped isoform of LMBR1 domain containing 2 OS=Bos taurus OX=9913 GN=LMBRD2 PE=3 SV=2 CANONICAL=F1N242-1" }, "locus": { "chromosome": "20", "start_pos": 38135083, "end_pos": 38105482, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107605.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107605.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089425.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089425.2" } ] } }, { "isoform_ac": "F1N242-1", "url": "https://www.uniprot.org/uniprotkb/F1N242/entry", "sequence": { "sequence": "MSGAALGLEIVFVFFLALFLLHRYGDFKKQHRLVIVGTLLAWYLCFLIVFILPLDVSTTIYNRCKHAAANSSPPEGSNMTGLYATATSVPSQHLCFKPWSYIPDGIMPIFWRVVYWTSQFLTWILLPFMQSYARSGGFSITGKIKTALIENAIYYGTYLLIFGAFLIYVAVNPHLHLEWNQLQTIGIAAANTWGLFLLVLLLGYGLVEIPRSYWNGAKRGYLLMKTYFKAAKLMTEKADAEETLEDVMEEVRKVNESIKYNHPLRKCVDTILKKCPIDYQEKMGRNMDDYEDFDEKHNTYPSEKSLVKLHKQVIYSVQRHRRTQVQWQILLEQAFYLEDVAKNETSATCQFVHTFQSPEPENRFIQYFYNPTVEWYWECLLRPWFYRILAVVLSIFSVIVVWSECTFFSTRPVLSLFAVFIQLAEKTYNYIYIEIACFLSIFFLSICVYSTVFRIRVFNYYYLASHHQTDAYSLLFSGMLFCRLTPPLCLNFLGLTHMDSSISHQNTQPTAYTSIMGSMKVLSFIADGFYIYYPMLVVILCIATYFSLGTRCLNLLGFQQFMGDNDMTSDLVDEGKELIRREKRKRQRQEEGENRRREWKERYGHSREDSTRNRNVHIDPKESNFSEMSTNRSTSKYTRANNRTERDRIELLQDAEPLDFNAETFTDDPLESESGSQTASSMKSKVMFACLAISPQSV", "length": 698, "header": "tr|F1N242-1|F1N242_BOVIN Isoform 1 of LMBR1 domain containing 2 OS=Bos taurus OX=9913 GN=LMBRD2 PE=3 SV=4 CANONICAL=F1N242-1" }, "locus": { "chromosome": "20", "start_pos": 38147660, "end_pos": 38105482, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026829.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026829.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026829.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026829.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510014", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510014", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N242", "url": "https://www.uniprot.org/uniprotkb/F1N242" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adrenergic receptor signaling pathway", "id": "GO:0071875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071875", "evidence": [ { "database": "UniProtKB", "id": "F1N242", "url": "https://www.uniprot.org/uniprotkb/F1N242" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" }, { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 }, { "start_pos": 343, "end_pos": 345 }, { "start_pos": 624, "end_pos": 626 }, { "start_pos": 631, "end_pos": 633 }, { "start_pos": 642, "end_pos": 644 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1Z6-1", "uniprot_ac": "F1N1Z6", "uniprot_id": "F1N1Z6_BOVIN", "mass": { "chemical_mass": 104278.0, "monoisotopic_mass": 104278.0 }, "refseq": {}, "gene_names": [ { "name": "ITIH5", "type": "recommended", "evidence": [ { "id": "F1N1Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" } ] } ], "protein_names": [ { "name": "Inter-alpha-trypsin inhibitor heavy chain 5", "type": "synonym", "evidence": [ { "id": "F1N1Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1Z6", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITIH5", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6", "locus": { "chromosome": "13", "start_pos": 16281657, "end_pos": 16200829, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013004", "url": "https://www.ensembl.org/id/ENSBTAG00000013004" } ] } } ], "crossref": [ { "id": "F1N1Z6", "url": "https://alphafold.ebi.ac.uk/entry/F1N1Z6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013004", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013004", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01461", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01461", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TWSYLTI", "url": "https://omabrowser.org/oma/group/TWSYLTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10338", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10338", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10338:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10338:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06668", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06668", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08487", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08487", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1Q4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Z6", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Z6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPLLGLCFALPLCAGLLEEARSWEDTSDQVGLRIPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVACRMLNRGSEDQEVTFQMQIPAAAFITNFTALIGDKVYQGEITEREKRNGDKVKEKRNKTIEDNGEKGTETFRASAVLPSKDKAAFLLSYEELLQRRLGKYEHVVSVRPQQLVGRLTVEVTVLERPGIAELEVLGLQNSRQRGSGRGPDDSGPPPSTVINQNETFAKVVFKPSVVQQAKIAQNGILGDFIVRYDVNREQSIGDIQVLDGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDHFNIVGFSNRIKVWKDHLVSVTPNSIRDGKVYIHHMSPSGGTDINGALQRGIQLLNDYVAHNDIEDRSVSLVVFLTDGKPTVGETHTLKILNNTREAARGRVCIFTVGIGADVDFKLLEKLSLENCGLTRRVHEDHDARAQLIGFYDEIRTPLLSDIRVDYPPSLVERATRTLFPNYFNGSEIVIAGKLVDRAMDRLHVEVTASNSKKFVVLKKDVPVEPRKVGIDVSQSPRPRGRGQEEPNHLERLWSYLTLKELLSAWLQSIEEPERERLRQEAQALAVNHHFLIPFTSMTLKSAPRTEAPEAAYGMSSTSMATGPETVMQSLRGTHLQPGPAVKKPYNPRIKISKTSADGDPHFVVDFPLSNLTVCFNIDGEPGHILRLVSDHADSGVTVNGELIGAPAPPNGHKKQRTYFRTITILVNKPERSYLEITPSRVIVDGGDRLVLPCNQSAVVGRRGLEVSVSANASVTVSIQGTVAFVVLLHLYKKPAPYQRNHLGFYIANGQGLSSNCHGLLGQFLNQEARLIGLSKSPAHPPVPEAGERSEAVLEVKGRQVPVVWKQRRIYNGEEQVDCWFARNNAAGLIDGEYKGYLAAHPFDSETAFGPGLSQGL", "length": 940, "header": "tr|F1N1Z6-1|F1N1Z6_BOVIN Isoform 1 of Inter-alpha-trypsin inhibitor heavy chain 5 OS=Bos taurus OX=9913 GN=ITIH5 PE=3 SV=2 CANONICAL=F1N1Z6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL0/entry", "sequence": { "sequence": "MLPLLGLCFALPLCAGLLEEARSWEDTSDQAYGTQLPDPGLNPSSLHWKVGLRIPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVACRMLNRGSEDQEVTFQMQIPAAAFITNFTALIGDKVYQGEITEREKRNGDKVKEKRNKTIEDNGEKGTETFRASAVLPSKDKAAFLLSYEELLQRRLGKYEHVVSVRPQQLVGRLTVEVTVLERPGIAELEVLGLQNSRQRGSGRGPDDSGPPPSTVINQNETFAKVVFKPSVVQQAKIAQNGILGDFIVRYDVNREQSIGDIQVLDGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDHFNIVGFSNRIKVWKDHLVSVTPNSIRDGKVYIHHMSPSGGTDINGALQRGIQLLNDYVAHNDIEDRSVSLVVFLTDGKPTVGETHTLKILNNTREAARGRVCIFTVGIGADVDFKLLEKLSLENCGLTRRVHEDHDARAQLIGFYDEIRTPLLSDIRVDYPPSLVERATRTLFPNYFNGSEIVIAGKLVDRAMDRLHVEVTASNSKKFVVLKKDVPVEPRKVGIDVSQSPRPRGRGQEEPNHLERLWSYLTLKELLSAWLQSIEEPERERLRQEAQALAVNHHFLIPFTSMTLKSAPRTEAPEAAYGMSSTSMATGPETVMQSLRGTHLQPGPAVKKPYNPRIKISKTSADGDPHFVVDFPLSNLTVCFNIDGEPGHILRLVSDHADSGVTVNGELIGAPAPPNGHKKQRTYFRTITILVNKPERSYLEITPSRVIVDGGDRLVLPCNQSAVVGRRGLEVSVSANASVTVSIQGTVAFVVLLHLYKKPAPYQRNHLGFYIANGQGLSSNCHGLLGQFLNQEARLIGLSKSPAHPPVPEAGERSEAVLEVKGRQVPVVWKQRRIYNGEEQVDCWFARNNAAGLIDGEYKGYLAAHPFDSETAFGPGLSQGL", "length": 959, "header": "tr|A0AAA9SLL0-1|F1N1Z6_BOVIN Computationally mapped isoform of Inter-alpha-trypsin inhibitor heavy chain 5 OS=Bos taurus OX=9913 GN=ITIH5 PE=3 SV=1 CANONICAL=F1N1Z6-1" }, "locus": { "chromosome": "13", "start_pos": 16281067, "end_pos": 16200889, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084841.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084841.1" } ] } }, { "isoform_ac": "A0ABI0P1Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Q4/entry", "sequence": { "sequence": "MLPLLGLCFALPLCAGLLEEARSWEDTSDQVGLRIPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVACRMLNRGSEDQEVTFQMQIPAAAFITNFTAVFQGEITEREKRNGDKVKEKRNKTIEDNGEKGTETFRASAVLPSKDKAAFLLSYEELLQRRLGKYEHVVSVRPQQLVGRLTVEVTVLERPGIAELEVLGLQNSRQRGSGRGPDDSGPPPSTVINQNETFAKVVFKPSVVQQAKIAQNGILGDFIVRYDVNREQSIGDIQVLDGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDHFNIVGFSNRIKVWKDHLVSVTPNSIRDGKVYIHHMSPSGGTDINGALQRGIQLLNDYVAHNDIEDRSVSLVVFLTDGKPTVGETHTLKILNNTREAARGRVCIFTVGIGADVDFKLLEKLSLENCGLTRRVHEDHDARAQLIGFYDEIRTPLLSDIRVDYPPSLVERATRTLFPNYFNGSEIVIAGKLVDRAMDRLHVEVTASNSKKFVVLKKDVPVEPRKVGIDVSQSPRPRGRGQEEPNHLERLWSYLTLKELLSAWLQSIEEPERERLRQEAQALAVNHHFLIPFTSMTLKSAPRTEAPEAAYGMSSTSMATGPETVMQSLRGTHLQPGPAVKKPYNPRIKISKTSADGDPHFVVDFPLSNLTVCFNIDGEPGHILRLVSDHADSGVTVNGELIGAPAPPNGHKKQRTYFRTITILVNKPERSYLEITPSRVIVDGGDRLVLPCNQSAVVGRRGLEVSVSANASVTVSIQGTVAFVVLLHLYKKPAPYQRNHLGFYIANGQGLSSNCHGLLGQFLNQEARLIGLSKSPAHPPVPEAGERSEAVLEVKGRQVPVVWKQRRIYNGEEQVDCWFARNNAAGLIDGEYKGYLAAHPFDSETAFGPGLSQGL", "length": 935, "header": "tr|A0ABI0P1Q4-1|A0ABI0P1Q4_BOVIN Computationally mapped isoform of Inter-alpha-trypsin inhibitor heavy chain 5 OS=Bos taurus OX=9913 GN=ITIH5 PE=3 SV=1 CANONICAL=F1N1Z6-1" }, "locus": { "chromosome": "13", "start_pos": 16281067, "end_pos": 16200889, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146040.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146040.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106998.1" } ] } }, { "isoform_ac": "F1N1Z6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6/entry", "sequence": { "sequence": "MLPLLGLCFALPLCAGLLEEARSWEDTSDQVGLRIPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVACRMLNRGSEDQEVTFQMQIPAAAFITNFTALIGDKVYQGEITEREKRNGDKVKEKRNKTIEDNGEKGTETFRASAVLPSKDKAAFLLSYEELLQRRLGKYEHVVSVRPQQLVGRLTVEVTVLERPGIAELEVLGLQNSRQRGSGRGPDDSGPPPSTVINQNETFAKVVFKPSVVQQAKIAQNGILGDFIVRYDVNREQSIGDIQVLDGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDHFNIVGFSNRIKVWKDHLVSVTPNSIRDGKVYIHHMSPSGGTDINGALQRGIQLLNDYVAHNDIEDRSVSLVVFLTDGKPTVGETHTLKILNNTREAARGRVCIFTVGIGADVDFKLLEKLSLENCGLTRRVHEDHDARAQLIGFYDEIRTPLLSDIRVDYPPSLVERATRTLFPNYFNGSEIVIAGKLVDRAMDRLHVEVTASNSKKFVVLKKDVPVEPRKVGIDVSQSPRPRGRGQEEPNHLERLWSYLTLKELLSAWLQSIEEPERERLRQEAQALAVNHHFLIPFTSMTLKSAPRTEAPEAAYGMSSTSMATGPETVMQSLRGTHLQPGPAVKKPYNPRIKISKTSADGDPHFVVDFPLSNLTVCFNIDGEPGHILRLVSDHADSGVTVNGELIGAPAPPNGHKKQRTYFRTITILVNKPERSYLEITPSRVIVDGGDRLVLPCNQSAVVGRRGLEVSVSANASVTVSIQGTVAFVVLLHLYKKPAPYQRNHLGFYIANGQGLSSNCHGLLGQFLNQEARLIGLSKSPAHPPVPEAGERSEAVLEVKGRQVPVVWKQRRIYNGEEQVDCWFARNNAAGLIDGEYKGYLAAHPFDSETAFGPGLSQGL", "length": 940, "header": "tr|F1N1Z6-1|F1N1Z6_BOVIN Isoform 1 of Inter-alpha-trypsin inhibitor heavy chain 5 OS=Bos taurus OX=9913 GN=ITIH5 PE=3 SV=2 CANONICAL=F1N1Z6-1" }, "locus": { "chromosome": "13", "start_pos": 16281067, "end_pos": 16200889, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048699.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048699.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045691.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045691.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1RUM0-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain 5", "gene_name": "ITIH5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLLLGLCLALPLCAGSLEEAGTWGDTSEQVGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASKDQEVTFQMQIPAAAFITNFTMLIGNQVYQGEITERDEKPGGQVKEKRNKTAEDNGEKGTEMFRASVVLPSKDKAAFFLSYEELLQRRLGKYEHVVSVRPQQLVGRLTVEVNVLERSGIAELEVLRLQNSRRKGSGSGEDDSGPPPSTVIHHNETFAHVVFKPSVVQQAKIAQNGILGDFIVRYDVSREQSIGDIQVLNGYFVHYFAPRDLPPLPKNVVFVLDSSASMVGAKLRQTKDALFTILHDLRPQDHFNIIGFSNRIKVWKDHLVSVTPNNVRDGKVYIHHMSPSGGTDINGALQTGIALLHDSVAPHDLEDRSVSLIVFLTDGKPTVGETHTPKILNNTREAARGRVCIFTVGIGDDVDFRLLEKLSLENCGFTRHVHEDEDAGAQLIGFYDEIRTPLLSDIRVDYPPDAVEQVTRTLFPNYFNGSEIIVAGKLADRAKDRLHVEVTASNSKKFVVLKKDVPVEPRWGGSGGPGGPGPQGGGQEDPNPLERLWSYLTLKELQSSWLQSDQEQERDRLRRKAQALAVAGRFLTPFTSMKLRPAPQAHTPEATYGLAGMSAAMGPEMVMQSLQGTHLQPGPALKKPYDPRIKISKTSADGDPHFVVDFPRSRLTVCFNIDGQPGDILRLVSDHADSGVTVNGELIGAPAPPHGHKKQRTYFHAITILVNKPQRSYLEITPSRVIVDGGDRQVLPCNQSTVVGSRGLEVSVSANANVTVTVQGTVAFVILFHLYKKPAPYQRNHLGFYIANGQGLSGNCHGLLGQFLNQEARLTEEAAGLSKNPTNPPVPEAGGRSKAILMVKGHQVPVVWKQRKIYNGEEQVDCWFAGNNAANLIDGEYKDYLAAHPFDSETTFGPGAPRGL", "length": 944 }, "evidence": [ { "id": "F1N1Z6", "url": "https://omabrowser.org/oma/group/F1N1Z6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0RAR2-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain 5", "gene_name": "Itih5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGQDWVRAGQSLPRCAHNWFSRSYSNSLKILPGPREVARSGFAMLLLLGLCLGLPLFSESQEEAQIWDDTSEQVMLRVPRQLRLLQRLKTKPLMAEFSVKSTIISRYAFTTVSCRMLNRASEDQDAEFQMQIPESAFITNFTMLIGDNVYQSEITEKEKKSSDRIKEKRNRTTDDNEEKGTDMFKASLVIPSKDKAAFFLSYEELLQRRLGKYEHIISVRPQQLVGRLTVEVNILERSGITSLEVLPLHNSRKKGSGKAEGDEGPPPSTIINHNETFAKVVFKPTVVQQAKIAQNGILGDFIIQYDVKREQNIGDIQVLDGYFVHYFAPKNLPPLPKNVVFVLDISASMVGAKLQQTREALVTILNDLRPQDRFNIIGFSNRIKMWKDHLLPVTPDNIRNGKIYMYHLSPTGGTDINGALQTAIKLLNNYVAQNDIEDRSVSLIIFLTDGKPTFGETNTLRILSNTKEATGGQICIFTVGIGNDVDFRLLEKLSLENCGLTRRVHEEEKAGAQLIGFYDEIRTPLLSDIRIDYPPDAVERVTKTLFPNYFNGSEIVIAGKMADKKFDQLHVEVTASNSKKFVILKRDIPVESRKMGNDVSVTPGSVSGGGKDPNHLERLWSYLTVKELLSSWVQSNSEQEKEQLRQKAQALALNYHFLTPFTSMKLKKPGLHPNQLEDTHGMSAATGPTTVVQNLREASMQPEPAPKKPYGPRIKISKTSVDGDPHFVVDFPISKLTVCFNIDGEPGDILRLVSDHLGSGVTVNGELIGAPAPPNGHKKHRTYFRTITILINQPERSYLEITPNRVILDGGDRLVLPCNQSMVVGSRGLEVSVSANANVTVTIQGTIAFVILIHLYKKPAPFQRNHLGFYIANSKGLSHNCHGLLGQFLNQDAKLVGAPEEYGKNLSNHQPSPRAEGMPEAILKVKGRRVPVVWKQRKIYNGLEQVDCWFDKNNAAKLIDGVYKDYLALHPFDTESARGPSMSRKAEPDSLHEESA", "length": 997 }, "evidence": [ { "id": "F1N1Z6", "url": "https://omabrowser.org/oma/group/F1N1Z6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86UX2-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H5", "gene_name": "ITIH5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLLLGLCLGLSLCVGSQEEAQSWGHSSEQDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAGSQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEPVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDILRLVSDHRDSGVTVNGELIGAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRHHLGFYIANSEGLSSNCHGLLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEEQIDCWFARNNAAKLIDGEYKDYLAFHPFDTGMTLGQGMSREL", "length": 942 }, "evidence": [ { "id": "F1N1Z6", "url": "https://omabrowser.org/oma/group/F1N1Z6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BJD1-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H5", "gene_name": "Itih5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLLLGLCLGLPLFSESQEEARSWDDTSEQVVLRVPRQLRLLQRLKTKPLMAEFSVKSTIISRYAFTTVSCRMLNRASEDQEAEFQMQIPESAFITNFTMLIGDSVYRGEITQKDKKSSESVKDKRNRTSDDNEENGSDMFKASLVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLVGRLTVEVDILERSGITSLEVLPLHNSRKKGSGKAEGDVGPPPSTLINQNETFAKVIFKPTVVQQAKIAQNGILGDFIVRYDVEREQNIGDIQVLNGYFVHYFAPKNLPPLPKNVVFVLDISASMVGAKLQQTREALVTILNDLRPQDRFNIIGFSNRIKMWKDHLLPVTPDNIRNGKIYMYHLSPTGGTDINGALQAAIKLLNNYVAQNDIEDRSVSLIIFLTDGKPTFGETNTLKILSNTKEATRGQICIFTVGIGDDVDFKLLEKLSLENCGLTRRVHEEDKAGAQLIGFYDEIRTPLLSDIRIDYPPDVVEHATKTLFPNYFNGSEIVIAGKMVDKKFDQLHVEVTASNSKKFVILKRDIPVEFRKMGNDVSVTPGSARDGGKDLNHIERLWSYLTVKELLSSWRQSNSEQEKEQLRQKAQDLALNYHFLTPFTSMKLRKPGLRTNQLEDTYGMSAATGPATVVQNLREAGKQPEPDLKKTYDPRIKISKTSVDGDPHFVVDFPLSKLTVCFNIDGEPGDILRLVSDHLNSGVTVNGELIGAPAPPNGHKKQRTYFRTITILINRPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSRGLEVSVSANANITVVIQGNIAFVILIHLYKNPAPFQRDHLGFYIANSRGLSDNCHGLLGQFLNQDAKLVGAPEEYGKNLSNQPFPRAEGMPEAILKVKGRRVPVVWKQRKIYNGQAQVDCWFDRNNAAKLIDGVYKDYLASHPFDTESALGLSTPRKPETDRPHEESV", "length": 952 }, "evidence": [ { "id": "F1N1Z6", "url": "https://omabrowser.org/oma/group/F1N1Z6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z6", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z6", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z6", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" } ], "pmid": "" }, { "name": "hyaluronan metabolic process", "id": "GO:0030212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030212", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z6", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 694, "end_pos": 696, "annotation": "n_glycosylation_sequon" }, { "start_pos": 778, "end_pos": 780, "annotation": "n_glycosylation_sequon" }, { "start_pos": 795, "end_pos": 797, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" }, { "id": "PS51468", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51468" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VIT", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 161, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z6" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 478, "start_aa": "Asn", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 508, "end_pos": 510 }, { "start_pos": 694, "end_pos": 696 }, { "start_pos": 778, "end_pos": 780 }, { "start_pos": 795, "end_pos": 797 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6L3-1", "uniprot_ac": "F1N6L3", "uniprot_id": "F1N6L3_BOVIN", "mass": { "chemical_mass": 89285.0, "monoisotopic_mass": 89285.0 }, "refseq": {}, "gene_names": [ { "name": "PTPN22", "type": "recommended", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ], "protein_names": [ { "name": "protein-tyrosine-phosphatase", "type": "recommended", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTPN22", "url": "https://www.uniprot.org/uniprotkb/F1N6L3", "locus": { "chromosome": "3", "start_pos": 29576961, "end_pos": 29504936, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019617", "url": "https://www.ensembl.org/id/ENSBTAG00000019617" } ] } } ], "crossref": [ { "id": "F1N6L3", "url": "https://alphafold.ebi.ac.uk/entry/F1N6L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019617", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019617", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14602", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14602", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N6L3", "url": "https://www.orthodb.org/?gene=F1N6L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45983:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45983:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-202427", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202427", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SUI4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1F7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6L3-1", "url": "https://www.uniprot.org/uniprotkb/F1N6L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDQREILQKFLDEAQHRKSNKEEFANEFLTLKRLSSKYKADKTYPTTVAERPKNIKKNRYKDILPYDHSLVELCMITSDEDSSYINANFIKGVYGPKTYIATQGPLPTTVLDFWRMIWEYSILIIVMACMEFEMGKKKCERYWAEPGDTQLQLGPFSISCEAENRKSDYTIRTLKAKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQDDNSVPICIHCSAGCGRTGVLCAIDYTWMLLKDGIIPENFSVFSLIQEMRTQRPSLVQTQQQYELVYNAVLELFTRQMDIIGDKHSGTEIQAKDSVFEQNPNIEAKSYSPSLPKSNIKEATVMNQQSKGRIRVKSAEASSFDLRTSEINEKEGLVMHSAKQSSSLEFLELNCGCNKNADTTMKWETKVFPIAGEPLQKHQSLDLSSILFGAYPKSKPVNAAGRYSNLKKPILRTKSTPFELMQERDSKELDIKGNFYLESQPHNSCVDQAQKVMHVSTAELNFSPLHDSKHQTCNAANAKQHDSGALNEHSYMSLVEDPYFSSLSPSSAHSKTSFNLPQKQDGSVLPCSSLSKSSTTLFPYYNSHDSLTLSTLTNFPPPLNQETAAVATSPRIDDEIPPPLPERTPESFIVVEEAGELPQGVPTSSSSPVKVKIGTSLECSGTSESKKSDDLVRLRPSKSVKPRSPKSDLQQDRSSSPPPPLPERTLESFLLADEDCTQAQPVETCSTSCPNTMENSTSSKQTLKPPGKNFTRSKSLKILRNVKKSICNSSPPNKPAETARSKNSSSFLNFGMCVTFQS", "length": 795, "header": "tr|F1N6L3-1|F1N6L3_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN22 PE=3 SV=4 CANONICAL=F1N6L3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI4/entry", "sequence": { "sequence": "MDQREILQKFLDEAQHRKSNKEEFANEFLTLKRLSSKYKADKTYPTTVAERPKNIKKNRYKDILPYDHSLVELCMITSDEDSSYINANFIKGVYGPKTYIATQGPLPTTVLDFWRMIWEYSILIIVMACMEFEMGKEAENRKSDYTIRTLKAKFNSVSVILPHQTSLQRLLGQKTPAPF", "length": 179, "header": "tr|A0AAA9SUI4-1|F1N6L3_BOVIN Computationally mapped isoform of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN22 PE=3 SV=1 CANONICAL=F1N6L3-1" }, "locus": { "chromosome": "3", "start_pos": 29573635, "end_pos": 29519988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088360.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088360.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087805.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087805.1" } ] } }, { "isoform_ac": "A0AAA9T1F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F7/entry", "sequence": { "sequence": "MDQREILQKFLDEAQHRKSNKEEFANEFLTLKRLSSKYKADKTYPTTVAERPKNIKKNRYKDILPYDHSLVELCMITSDEDSSYINANFIKGVYGPKTYIATQGPLPTTVLDFWRMIWEYSILIIVMACMEFEMGKKKCERYWAEPGDTQLQLGPFSISCEAENRKSDYTIRTLKAKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQDDNSVPICIHCSAGCGRTGVLCAIDYTWMLLKDGQQYELVYNAVLELFTRQMDIIGDKHSGTEIQAKDSVFEQNPNIEAKSYSPSLPKSNIKEATVMNQQSKGRIRVKSAEASSFDLRTSEINEKEGLVMHSAKQSSSLEFLELNCGCNKNADTTMKWETKVFPIAGEPLQKHQSLDLSSILFGAYPKSKPVNAAGRYSNLKKPILRTKSTPFELMQERDSKELDIKGNFYLESQPHNSCVDQAQKVMHVSTAELNFSPLHDSKHQTCNAANAKQHDSGALNEHSYMSLVEDPYFSSLSPSSAHSKTSFNLPQKQDGSVLPCSSLSKSSTTLFPYYNSHDSLTLSTLTNFPPPLNQETAAVATSPRIDDEIPPPLPERTPESFIVVEEAGELPQGVPTSSSSPVKVKIGTSLECSGTSESKKSDDLSVKPRSPKSDLQQDRSSSPPPPLPERTLESFLLADEDCTQAQPVETCSTSCPNTMENSTSSKQTLKPPGKNFTRSKSLKILRNVKKSICNSSPPNKPAETARSKNSSSFLNFGFANRFSKPKGPRNPPSTWKI", "length": 775, "header": "tr|A0AAA9T1F7-1|F1N6L3_BOVIN Computationally mapped isoform of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN22 PE=3 SV=1 CANONICAL=F1N6L3-1" }, "locus": { "chromosome": "3", "start_pos": 29575957, "end_pos": 29519988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123654.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123654.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089489.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089489.1" } ] } }, { "isoform_ac": "F1N6L3-1", "url": "https://www.uniprot.org/uniprotkb/F1N6L3/entry", "sequence": { "sequence": "MDQREILQKFLDEAQHRKSNKEEFANEFLTLKRLSSKYKADKTYPTTVAERPKNIKKNRYKDILPYDHSLVELCMITSDEDSSYINANFIKGVYGPKTYIATQGPLPTTVLDFWRMIWEYSILIIVMACMEFEMGKKKCERYWAEPGDTQLQLGPFSISCEAENRKSDYTIRTLKAKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQDDNSVPICIHCSAGCGRTGVLCAIDYTWMLLKDGIIPENFSVFSLIQEMRTQRPSLVQTQQQYELVYNAVLELFTRQMDIIGDKHSGTEIQAKDSVFEQNPNIEAKSYSPSLPKSNIKEATVMNQQSKGRIRVKSAEASSFDLRTSEINEKEGLVMHSAKQSSSLEFLELNCGCNKNADTTMKWETKVFPIAGEPLQKHQSLDLSSILFGAYPKSKPVNAAGRYSNLKKPILRTKSTPFELMQERDSKELDIKGNFYLESQPHNSCVDQAQKVMHVSTAELNFSPLHDSKHQTCNAANAKQHDSGALNEHSYMSLVEDPYFSSLSPSSAHSKTSFNLPQKQDGSVLPCSSLSKSSTTLFPYYNSHDSLTLSTLTNFPPPLNQETAAVATSPRIDDEIPPPLPERTPESFIVVEEAGELPQGVPTSSSSPVKVKIGTSLECSGTSESKKSDDLVRLRPSKSVKPRSPKSDLQQDRSSSPPPPLPERTLESFLLADEDCTQAQPVETCSTSCPNTMENSTSSKQTLKPPGKNFTRSKSLKILRNVKKSICNSSPPNKPAETARSKNSSSFLNFGMCVTFQS", "length": 795, "header": "tr|F1N6L3-1|F1N6L3_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN22 PE=3 SV=4 CANONICAL=F1N6L3-1" }, "locus": { "chromosome": "3", "start_pos": 29573670, "end_pos": 29519988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026136.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026136.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026136.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026136.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-202427", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202427", "resource": "Reactome", "description": "Phosphorylation of CD3 and TCR zeta chains" }, { "id": "R-BTA-202430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202430", "resource": "Reactome", "description": "Translocation of ZAP-70 to Immunological synapse" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "positive regulation of toll-like receptor 3 signaling pathway", "id": "GO:0034141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034141", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of protein import into nucleus", "id": "GO:0042307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042307", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor production", "id": "GO:0032720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of defense response to virus by host", "id": "GO:0002230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of CD8-positive, alpha-beta T cell proliferation", "id": "GO:2000566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000566", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "regulation of leukocyte migration", "id": "GO:0002685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002685", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "cellular response to muramyl dipeptide", "id": "GO:0071225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071225", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901222", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "negative regulation of interleukin-8 production", "id": "GO:0032717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032717", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 4 signaling pathway", "id": "GO:0034145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034145", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 7 signaling pathway", "id": "GO:0034157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034157", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 9 signaling pathway", "id": "GO:0034165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034165", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "phosphoanandamide dephosphorylation", "id": "GO:0035644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035644", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "negative regulation of T cell activation", "id": "GO:0050868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050868", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway", "id": "GO:0070433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070433", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of granzyme B production", "id": "GO:0071663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071663", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "negative regulation of p38MAPK cascade", "id": "GO:1903753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903753", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of NLRP3 inflammasome complex assembly", "id": "GO:1900227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900227", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "regulation of innate immune response", "id": "GO:0045088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045088", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of protein K63-linked ubiquitination", "id": "GO:1902523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902523", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "F1N6L3", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 746, "end_pos": 748, "annotation": "n_glycosylation_sequon" }, { "start_pos": 765, "end_pos": 767, "annotation": "n_glycosylation_sequon" }, { "start_pos": 780, "end_pos": 782, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-BTA-8852200", "name": "Inactivation of LCK by PTPN22", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6L3-1" ], "evidence": [ { "id": "R-BTA-8852200", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852200" } ] }, { "id": "R-BTA-8855375", "name": "PTPN22 dissociates from CSK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VBZ0-1", "F1N6L3-1" ], "evidence": [ { "id": "R-BTA-8855375", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8855375" } ] }, { "id": "R-BTA-8855381", "name": "PTPN22 dephosphorylates ZAP70", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BMP9-1", "F1N6L3-1" ], "evidence": [ { "id": "R-BTA-8855381", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8855381" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BMP9", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0VBZ0", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 280, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" }, { "id": "PS50055", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50055" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 289, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 }, { "start_pos": 498, "end_pos": 500 }, { "start_pos": 732, "end_pos": 734 }, { "start_pos": 746, "end_pos": 748 }, { "start_pos": 765, "end_pos": 767 }, { "start_pos": 780, "end_pos": 782 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6PXY2-1", "uniprot_ac": "F6PXY2", "uniprot_id": "F6PXY2_BOVIN", "mass": { "chemical_mass": 57744.0, "monoisotopic_mass": 57744.0 }, "refseq": { "ac": "XP_024853714", "name": "homeobox and leucine zipper protein Homez isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853714" }, "gene_names": [ { "name": "HOMEZ", "type": "recommended", "evidence": [ { "id": "F6PXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ] }, { "name": "HOMEZ", "type": "synonym", "evidence": [ { "id": "XP_024853714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853714" } ] } ], "protein_names": [ { "name": "Homeobox and leucine zipper protein Homez", "type": "recommended", "evidence": [ { "id": "F6PXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PXY2/entry#names_and_taxonomy" } ] }, { "name": "Homeodomain leucine zipper-containing factor", "type": "synonym", "evidence": [ { "id": "F6PXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PXY2/entry#names_and_taxonomy" } ] }, { "name": "homeobox and leucine zipper protein Homez isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024853714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853714" } ] } ], "function": [ { "annotation": "May function as a transcriptional regulator.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW9#function" }, { "database": "UniProtKB", "id": "ARBA00059151", "url": "https://www.uniprot.org/uniprotkb/ARBA00059151#function" }, { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOMEZ", "url": "https://www.uniprot.org/uniprotkb/F6PXY2", "locus": { "chromosome": "10", "start_pos": 21630418, "end_pos": 21620210, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032686", "url": "https://www.ensembl.org/id/ENSBTAG00000032686" } ] } } ], "crossref": [ { "id": "ENSBTAG00000032686", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032686", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614181", "url": "https://www.ncbi.nlm.nih.gov/gene/614181", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6PXY2", "url": "https://www.orthodb.org/?gene=F6PXY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15467", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15467", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15467:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15467:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11569", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11569", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024853714", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853714", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXY2-1", "url": "https://www.uniprot.org/uniprotkb/F6PXY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPNKEASSLNSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLQTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLHFKSLLSFTHHAGRPPEEMPPSPVPPPEQVGLGIVPLTLSEPTQMKGLKVEPEESLSHQKAKEPLMVPGSGAFPHQSQFWQDHQCSGLSKEQAGRCPDQSHSLATASWNHATAVHQPRARDKPQSISLLASSCKKESASNVTPPSSTSSSFQGLANGAPATSKPLQPLGCAPQPLSPNEQALPPQLEPAWPQGLRHNSASGRIGPAEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAVPTPPPSTRSLNEWAETPPLPNPPPPPDIRPLERYWATHQQLRESDIPQLSQASRLSTQQVLDWFDSRLPEPAEVVVCLDEEEEEEEEELPEDGEEEEEEDDDDDDDDVIIQD", "length": 515, "header": "tr|F6PXY2-1|F6PXY2_BOVIN Isoform 1 of Homeobox and leucine zipper protein Homez OS=Bos taurus OX=9913 GN=HOMEZ PE=4 SV=4 CANONICAL=F6PXY2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW9/entry", "sequence": { "sequence": "MVRGWEPPPGLDCAISEGHKSESTMPPNKEASSLNSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLQTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLHFKSLLSFTHHAGRPPEEMPPSPVPPPEQVGLGIVPLTLSEPTQMKGLKGLANGAPATSKPLQPLGCAPQPLSPNEQALPPQLEPAWPQGLRHNSASGRIGPAEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAVPTPPPSTRSLNEWAETPPLPNPPPPPDIRPLERYWATHQQLRESDIPQLSQASRLSTQQVLDWFDSRLPEPAEVVVCLDEEEEEEEEELPEDGEEEEEEDDDDDDDDVIIQD", "length": 436, "header": "tr|A0AAA9SVW9-1|F6PXY2_BOVIN Computationally mapped isoform of Homeobox and leucine zipper protein Homez OS=Bos taurus OX=9913 GN=HOMEZ PE=4 SV=2 CANONICAL=F6PXY2-1" }, "locus": { "chromosome": "10", "start_pos": 21627521, "end_pos": 21620603, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108275.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108275.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088163.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088163.2" } ] } }, { "isoform_ac": "F6PXY2-1", "url": "https://www.uniprot.org/uniprotkb/F6PXY2/entry", "sequence": { "sequence": "MPPNKEASSLNSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLQTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLHFKSLLSFTHHAGRPPEEMPPSPVPPPEQVGLGIVPLTLSEPTQMKGLKVEPEESLSHQKAKEPLMVPGSGAFPHQSQFWQDHQCSGLSKEQAGRCPDQSHSLATASWNHATAVHQPRARDKPQSISLLASSCKKESASNVTPPSSTSSSFQGLANGAPATSKPLQPLGCAPQPLSPNEQALPPQLEPAWPQGLRHNSASGRIGPAEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAVPTPPPSTRSLNEWAETPPLPNPPPPPDIRPLERYWATHQQLRESDIPQLSQASRLSTQQVLDWFDSRLPEPAEVVVCLDEEEEEEEEELPEDGEEEEEEDDDDDDDDVIIQD", "length": 515, "header": "tr|F6PXY2-1|F6PXY2_BOVIN Isoform 1 of Homeobox and leucine zipper protein Homez OS=Bos taurus OX=9913 GN=HOMEZ PE=4 SV=4 CANONICAL=F6PXY2-1" }, "locus": { "chromosome": "10", "start_pos": 21627521, "end_pos": 21625977, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105304.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105304.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088123.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088123.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 405, "start_aa": "Thr", "end_pos": 405, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr405", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F6PXY2", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6PXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PXY2" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 322, "end_pos": 382, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 405 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 249, "end_pos": 251 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4S8-1", "uniprot_ac": "F1N4S8", "uniprot_id": "F1N4S8_BOVIN", "mass": { "chemical_mass": 14600.0, "monoisotopic_mass": 14600.0 }, "refseq": { "ac": "NP_001033165", "name": "C-C motif chemokine 21 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033165" }, "gene_names": [ { "name": "CCL21", "type": "recommended", "evidence": [ { "id": "F1N4S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ] }, { "name": "CCL21", "type": "synonym", "evidence": [ { "id": "NP_001033165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033165" } ] } ], "protein_names": [ { "name": "C-C motif chemokine 21 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033165" } ] }, { "name": "C-C motif chemokine ligand 21", "type": "synonym", "evidence": [ { "id": "F1N4S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S8/entry#names_and_taxonomy" } ] }, { "name": "chemokine (C-C motif) ligand 21", "type": "synonym", "evidence": [ { "id": "NP_001033165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033165" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCL21", "url": "https://www.uniprot.org/uniprotkb/F1N4S8", "locus": { "chromosome": "8", "start_pos": 76080470, "end_pos": 76081730, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010161", "url": "https://www.ensembl.org/id/ENSBTAG00000010161" } ] } } ], "crossref": [ { "id": "F1N4S8", "url": "https://alphafold.ebi.ac.uk/entry/F1N4S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010161", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010161", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511112", "url": "https://www.ncbi.nlm.nih.gov/gene/511112", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511112", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511112", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKRTEQP", "url": "https://omabrowser.org/oma/group/CKRTEQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4S8", "url": "https://www.orthodb.org/?gene=F1N4S8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-380108", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033165", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMAQSLVLSILVLVLAFCILQVQGSDGGAQDCCLRYSRKKIPANIVRSYRKQDPTLSCAMPAILFSPRKRSQPELCADPKEAWVQKLMQRLDKPSAPRKPVQDCKKEKGAPKSGKKGKGSKGCKRTEISKGP", "length": 133, "header": "tr|F1N4S8-1|F1N4S8_BOVIN Isoform 1 of C-C motif chemokine ligand 21 OS=Bos taurus OX=9913 GN=CCL21 PE=3 SV=2 CANONICAL=F1N4S8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1C5/entry", "sequence": { "sequence": "MAMAQSLVLSILVLVLAFCILQVQGSDGGAQDCCLRYSRKKIPANIVRSYRKQDPTLSCAMPAILFSPRKRSQPELCADPKEAWVQKLMQRLDKPSAPRKPVQDCKKEKGAPKSGKKGKGSKGCKREATVTTGGVTHSKVPIRSSGWKNSMFS", "length": 153, "header": "tr|A0AAA9T1C5-1|F1N4S8_BOVIN Computationally mapped isoform of C-C motif chemokine ligand 21 OS=Bos taurus OX=9913 GN=CCL21 PE=3 SV=1 CANONICAL=F1N4S8-1" }, "locus": { "chromosome": "8", "start_pos": 76081682, "end_pos": 76080471, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123991.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123991.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089446.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089446.1" } ] } }, { "isoform_ac": "F1N4S8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S8/entry", "sequence": { "sequence": "MAMAQSLVLSILVLVLAFCILQVQGSDGGAQDCCLRYSRKKIPANIVRSYRKQDPTLSCAMPAILFSPRKRSQPELCADPKEAWVQKLMQRLDKPSAPRKPVQDCKKEKGAPKSGKKGKGSKGCKRTEISKGP", "length": 133, "header": "tr|F1N4S8-1|F1N4S8_BOVIN Isoform 1 of C-C motif chemokine ligand 21 OS=Bos taurus OX=9913 GN=CCL21 PE=3 SV=2 CANONICAL=F1N4S8-1" }, "locus": { "chromosome": "8", "start_pos": 76081682, "end_pos": 76080995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033670.4", "url": "https://www.ensembl.org/id/ENSBTAT00000033670.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033580.3", "url": "https://www.ensembl.org/id/ENSBTAP00000033580.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511112", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511112", "resource": "KEGG Pathway" }, { "id": "R-BTA-380108", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "resource": "Reactome", "description": "Chemokine receptors bind chemokines" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "O00585-1", "protein_name": "C-C motif chemokine 21", "gene_name": "CCL21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP", "length": 134 }, "evidence": [ { "id": "F1N4S8", "url": "https://omabrowser.org/oma/group/F1N4S8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P84444-1", "protein_name": "C-C motif chemokine 21a", "gene_name": "Ccl21a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFSPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPGCRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG", "length": 133 }, "evidence": [ { "id": "F1N4S8", "url": "https://omabrowser.org/oma/group/F1N4S8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 27, "go_terms": [ { "name": "negative regulation of dendritic cell apoptotic process", "id": "GO:2000669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000669", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of cell adhesion mediated by integrin", "id": "GO:0033630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033630", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "cellular response to prostaglandin E stimulus", "id": "GO:0071380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071380", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "release of sequestered calcium ion into cytosol", "id": "GO:0051209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051209", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of pseudopodium assembly", "id": "GO:0031274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031274", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "ruffle organization", "id": "GO:0031529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031529", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "dendritic cell chemotaxis", "id": "GO:0002407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002407", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of filopodium assembly", "id": "GO:0051491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "mesangial cell-matrix adhesion", "id": "GO:0035759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035759", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of neutrophil chemotaxis", "id": "GO:0090023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090023", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of cell-matrix adhesion", "id": "GO:0001954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001954", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "negative regulation of leukocyte tethering or rolling", "id": "GO:1903237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903237", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "establishment of T cell polarity", "id": "GO:0001768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001768", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of myeloid dendritic cell chemotaxis", "id": "GO:2000529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000529", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "CCL21-activated CCR7 signaling pathway", "id": "GO:0038120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038120", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of phospholipase C/protein kinase C signal transduction", "id": "GO:0141214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141214", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "id": "GO:0061844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "chemokine-mediated signaling pathway", "id": "GO:0070098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070098", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "eosinophil chemotaxis", "id": "GO:0048245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048245", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" }, { "name": "CCR chemokine receptor binding", "id": "GO:0048020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048020", "evidence": [ { "database": "UniProtKB", "id": "F1N4S8", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S8" }, { "id": "SM00199", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chemokine interleukin-8-like", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 92, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Y5-1", "uniprot_ac": "F1N6Y5", "uniprot_id": "F1N6Y5_BOVIN", "mass": { "chemical_mass": 212318.0, "monoisotopic_mass": 212318.0 }, "refseq": { "ac": "XP_024833470", "name": "histone-lysine N-methyltransferase SETD1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833470" }, "gene_names": [ { "name": "SETD1B", "type": "recommended", "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ] }, { "name": "SETD1B", "type": "synonym", "evidence": [ { "id": "XP_024833470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833470" } ] } ], "protein_names": [ { "name": "[histone H3]-lysine(4) N-methyltransferase", "type": "recommended", "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.364", "type": "synonym", "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5/entry#names_and_taxonomy" } ] }, { "name": "histone-lysine N-methyltransferase SETD1B", "type": "synonym", "evidence": [ { "id": "XP_024833470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833470" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SETD1B", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5", "locus": { "chromosome": "17", "start_pos": 53476991, "end_pos": 53499853, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004172", "url": "https://www.ensembl.org/id/ENSBTAG00000004172" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004172", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004172", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12549", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12549", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19169", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19169", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514102", "url": "https://www.ncbi.nlm.nih.gov/gene/514102", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514102", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514102", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N6Y5", "url": "https://www.orthodb.org/?gene=F1N6Y5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45814:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45814:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11764", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11764", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214841", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8936459", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936459", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9772755", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024833470", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833470", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60264", "url": "https://www.rhea-db.org/rhea/60264", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60268", "url": "https://www.rhea-db.org/rhea/60268", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60272", "url": "https://www.rhea-db.org/rhea/60272", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T3J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y5-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSSSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPTTTFKARRHESKFTDAYNRRHEHHYVHNSSAVTAVAGATAAFRGAVDLPFGAVGGSGGSSGPPFKAQPQDSATFAHTPPPTQATPAPGVAFKSAFSPYQTPVPPFPPPPEEPTTTAPFGARDSGEFRRAPAPPPLPPAEPLTKEKPGTPPGPPPPEANSIELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTELQMEGSPISSSSSQLSPLAPFGANSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDGELDLGLGPRPPPEPGPPDPTGLLGQTSETALDLAGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGSMPMSFQMQTQMLSRLMTGQGTCPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLGNTGPGRGQPWPPLPKFDPSVPPPGYVPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLSYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDMADAPCELAKRDPKGMGVRRRPARPLELDSGGEEDEKESLSVSSSSSASSSSGSSTTSPSSSASDKEERESTEEEEEGEGEEEGEEGPRSQISSSSTSSMSDKDDDDEDSDDRDESENDDEDTALSEASEKEEGDSDGEETVSITTSKPGAESSSESSESSDFASSSESSSSSSSEDEEELPAGEDEEEEEEEGEAAADESMAPTAPDEDFENEVVTGAPTTESQGPEEEVDIEAEDEAPKERTPMLEEPPLPVSVEELTGCKEPPGEPGLNQEGARLLSPEPPAGEMEARPLPSPEPTPEDNLEAEPEAPALLSLPLQPPLPPPRPPRPPSPPPEPKTPDPPLPSVPLEPPPHEEQPPRTPSLCGSLGKSQSAEAVPATPSGEPLPTAGSGGLALSSPQLPGSPFSYPSPSPSLSSGGLPRTPGRDFSFTPTFPEPGGPLLLPVCPLPAGRRDDRSGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQSRAPTQLPPLLPAPLAPCPPPIKRKPGRPRRSPPAVLTLDGPLVRPPGGAALGRDLLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELENQWPSEAIPPGPRGRDEISDEFMAKVRGSWRRPPKKRHEDLVVSASPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHMTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPTDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN", "length": 1966, "header": "tr|F1N6Y5-1|F1N6Y5_BOVIN Isoform 1 of [histone H3]-lysine(4) N-methyltransferase OS=Bos taurus OX=9913 GN=SETD1B PE=4 SV=4 CANONICAL=F1N6Y5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J6/entry", "sequence": { "sequence": "MLIWLKSWFPLLSSAPGGGGRGAEEEAVAEIPRLQLVWGPPCRPSRLRASKHTIIHPKTSPFPWVPTRPPRVLAVWKQFWRPEAQAAAAAARRVAPAAGGWVNGMENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSSSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPTTTFKARRHESKFTDAYNRRHEHHYVHNSSAVTAVAGATAAFRGAVDLPFGAVGGSGGSSGPPFKAQPQDSATFAHTPPPTQATPAPGVAFKSAFSPYQTPVPPFPPPPEEPTTTAPFGARDSGEFRRAPAPPPLPPAEPLTKEKPGTPPGPPPPEANSIELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTELQMEGSPISSSSSQLSPLAPFGANSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDGELDLGLGPRPPPEPGPPDPTGLLGQTSETALDLAGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGSMPMSFQMQTQMLSRLMTGQGTCPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLGNTGPGRGQPWPPLPKFDPSVPPPGYVPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLSYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDMADAPCELAKRDPKGMGVRRRPARPLELDSGGEEDEKESLSVSSSSSASSSSGSSTTSPSSSASDKEERESTEEEEEGEGEEEGEEGPRSQISSSSTSSMSDKDDDDEDSDDRDESENDDEDTALSEASEKEEGDSDGEETVSITTSKPGAESSSESSESSDFASSSESSSSSSSEDEEELPAGEDEEEEEEEGEAAADESMAPTAPDEDFENEVVTGAPTTESQGPEEEVDIEAEDEAPKERTPMLEEPPLPVSVEELTGCKEPPGEPGLNQEGARLLSPEPPAGEMEARPLPSPEPTPEDNLEAEPEAPALLSLPLQPPLPPPRPPRPPSPPPEPKTPDPPLPSVPLEPPPHEEQPPRTPSLCGSLGKSQSAEAVPATPSGEPLPTAGSGGLALSSPQLPGSPFSYPSPSPSLSSGGLPRTPGRDFSFTPTFPEPGGPLLLPVCPLPAGRRDDRSGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQSRAPTQLPPLLPAPLAPCPPPIKRKPGRPRRSPPAVLTLDGPLVRPPGGAALGRDLLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELENQWPSEAIPPGPRGRDEISDEFMAKVRGSWRRPPKKRHEDLVVSASPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHMTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPTDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN", "length": 2070, "header": "tr|A0AAA9T3J6-1|F1N6Y5_BOVIN Computationally mapped isoform of [histone H3]-lysine(4) N-methyltransferase OS=Bos taurus OX=9913 GN=SETD1B PE=4 SV=1 CANONICAL=F1N6Y5-1" }, "locus": { "chromosome": "17", "start_pos": 53499737, "end_pos": 53477995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135263.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135263.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090266.1" } ] } }, { "isoform_ac": "A0AAA9T4X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4X9/entry", "sequence": { "sequence": "MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSSSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPTTTFKARRHESKFTDAYNRRHEHHYVHNSSAVTAVAGATAAFRGAVDLPFGAVGGSGGSSGPPFKAQPQDSATFAHTPPPTQATPAPGVAFKSAFSPYQTPVPPFPPPPEEPTTTAPFGARDSGEFRRAPAPPPLPPAEPLTKEKPGTPPGPPPPEANSIELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTELQMEGSPISSSSSQLSPLAPFGANSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDGELDLGLGPRPPPEPGPPDPTGLLGQTSETALDLAGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMMQTQMLSRLMTGQGTCPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLGNTGPGRGQPWPPLPKFDPSVPPPGYVPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLSYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDMADAPCELAKRDPKGMGVRRRPARPLELDSGGEEDEKESLSVSSSSSASSSSGSSTTSPSSSASDKEERESTEEEEEGEGEEEGEEGPRSQISSSSTSSMSDKDDDDEDSDDRDESENDDEDTALSEASEKEEGDSDGEETVSITTSKPGAESSSESSESSDFASSSESSSSSSSEDEEELPAGEDEEEEEEEGEAAADESMAPTAPDEDFENEVVTGAPTTESQGPEEEVDIEAEDEAPKERTPMLEEPPLPVSVEELTGCKEPPGEPGLNQEGARLLSPEPPAGEMEARPLPSPEPTPEDNLEAEPEAPALLSLPLQPPLPPPRPPRPPSPPPEPKTPDPPLPSVPLEPPPHEEQPPRTPSLCGSLGKSQSAEAVPATPSGEPLPTAGSGGLALSSPQLPGSPFSYPSPSPSLSSGGLPRTPGRDFSFTPTFPEPGGPLLLPVCPLPAGRRDDRSGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQSRAPTQLPPLLPAPLAPCPPPIKRKPGRPRRSPPAVLTLDGPLVRPPGGAALGRDLLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELENQWPSEAIPPGPRGRDEISDEFMAKVRGSWRRPPKKRHEDLVVSASPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHMTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPTDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN", "length": 1849, "header": "tr|A0AAA9T4X9-1|F1N6Y5_BOVIN Computationally mapped isoform of [histone H3]-lysine(4) N-methyltransferase OS=Bos taurus OX=9913 GN=SETD1B PE=4 SV=1 CANONICAL=F1N6Y5-1" }, "locus": { "chromosome": "17", "start_pos": 53498420, "end_pos": 53477995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127901.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127901.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091567.1" } ] } }, { "isoform_ac": "F1N6Y5-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5/entry", "sequence": { "sequence": "MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSSSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPTTTFKARRHESKFTDAYNRRHEHHYVHNSSAVTAVAGATAAFRGAVDLPFGAVGGSGGSSGPPFKAQPQDSATFAHTPPPTQATPAPGVAFKSAFSPYQTPVPPFPPPPEEPTTTAPFGARDSGEFRRAPAPPPLPPAEPLTKEKPGTPPGPPPPEANSIELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTELQMEGSPISSSSSQLSPLAPFGANSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDGELDLGLGPRPPPEPGPPDPTGLLGQTSETALDLAGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGSMPMSFQMQTQMLSRLMTGQGTCPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLGNTGPGRGQPWPPLPKFDPSVPPPGYVPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLSYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDMADAPCELAKRDPKGMGVRRRPARPLELDSGGEEDEKESLSVSSSSSASSSSGSSTTSPSSSASDKEERESTEEEEEGEGEEEGEEGPRSQISSSSTSSMSDKDDDDEDSDDRDESENDDEDTALSEASEKEEGDSDGEETVSITTSKPGAESSSESSESSDFASSSESSSSSSSEDEEELPAGEDEEEEEEEGEAAADESMAPTAPDEDFENEVVTGAPTTESQGPEEEVDIEAEDEAPKERTPMLEEPPLPVSVEELTGCKEPPGEPGLNQEGARLLSPEPPAGEMEARPLPSPEPTPEDNLEAEPEAPALLSLPLQPPLPPPRPPRPPSPPPEPKTPDPPLPSVPLEPPPHEEQPPRTPSLCGSLGKSQSAEAVPATPSGEPLPTAGSGGLALSSPQLPGSPFSYPSPSPSLSSGGLPRTPGRDFSFTPTFPEPGGPLLLPVCPLPAGRRDDRSGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQSRAPTQLPPLLPAPLAPCPPPIKRKPGRPRRSPPAVLTLDGPLVRPPGGAALGRDLLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELENQWPSEAIPPGPRGRDEISDEFMAKVRGSWRRPPKKRHEDLVVSASPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKRDDGIREHMTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPTDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN", "length": 1966, "header": "tr|F1N6Y5-1|F1N6Y5_BOVIN Isoform 1 of [histone H3]-lysine(4) N-methyltransferase OS=Bos taurus OX=9913 GN=SETD1B PE=4 SV=4 CANONICAL=F1N6Y5-1" }, "locus": { "chromosome": "17", "start_pos": 53498420, "end_pos": 53477995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022553.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022553.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022553.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022553.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1303, "start_aa": "Thr", "end_pos": 1303, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1303", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1384, "start_aa": "Thr", "end_pos": 1384, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1384", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 295, "start_aa": "Thr", "end_pos": 295, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr295", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 385, "start_aa": "Thr", "end_pos": 385, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr385", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 388, "start_aa": "Thr", "end_pos": 388, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr388", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 577, "start_aa": "Thr", "end_pos": 577, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr577", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 665, "start_aa": "Thr", "end_pos": 665, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr665", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 726, "start_aa": "Thr", "end_pos": 726, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr726", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514102", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514102", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214841", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214841", "resource": "Reactome", "description": "PKMTs methylate histone lysines" }, { "id": "R-BTA-8936459", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936459", "resource": "Reactome", "description": "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" }, { "id": "R-BTA-9772755", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "resource": "Reactome", "description": "Formation of WDR5-containing histone-modifying complexes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" }, { "name": "histone H3K4 monomethyltransferase activity", "id": "GO:0140945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140945", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" }, { "name": "histone H3K4 methyltransferase activity", "id": "GO:0042800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042800", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" }, { "name": "Set1C/COMPASS complex", "id": "GO:0048188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048188", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y5", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1715, "end_pos": 1717, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1765, "end_pos": 1767, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1905, "end_pos": 1907, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60264", "name": "", "equation": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TQW6-1", "E1B9N8-1", "F1MHA1-1", "E1BKN0-1", "E1B906-1", "F1N6Y5-1", "E1BLX2-1", "A0ABI0NZS0-1" ], "evidence": [ { "id": "60264", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60264" } ] }, { "id": "60268", "name": "", "equation": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHA1-1", "E1B906-1", "E1BKN0-1", "F1N6Y5-1", "E1BLX2-1" ], "evidence": [ { "id": "60268", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60268" } ] }, { "id": "60272", "name": "", "equation": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6Y5-1", "E1BLX2-1" ], "evidence": [ { "id": "60272", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60272" } ] }, { "id": "R-BTA-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MXG0-1", "A0AAA9RUH2-1", "F1N6Y5-1", "E1BKH5-1" ], "evidence": [ { "id": "R-BTA-4827382", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4827382" } ] }, { "id": "R-BTA-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MF12-1", "E1BKN0-1", "F1N6Y5-1", "A0AAA9TQW6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-5159245", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5159245" } ] }, { "id": "R-BTA-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BKN0-1", "F1N6Y5-1", "G3X834-1", "A0AAA9TQW6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-5244692", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5244692" } ] }, { "id": "R-BTA-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MF12-1", "E1BKN0-1", "F1N6Y5-1", "A0AAA9TQW6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-5637686", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5637686" } ] }, { "id": "R-BTA-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BKN0-1", "A0ABZ3NNC5-1", "F1N6Y5-1", "A0AAA9TQW6-1", "A0A3Q1MLT2-1", "E1B8D6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-8936481", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936481" } ] }, { "id": "R-BTA-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BKN0-1", "A0ABZ3NNC5-1", "F1N6Y5-1", "A0AAA9TQW6-1", "A0A3Q1MLT2-1", "E1B8D6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-8936621", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936621" } ] }, { "id": "R-BTA-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BKN0-1", "A0ABZ3NNC5-1", "F1N6Y5-1", "A0AAA9TQW6-1", "A0A3Q1MLT2-1", "E1B8D6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-8937016", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937016" } ] }, { "id": "R-BTA-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BKN0-1", "A0ABZ3NNC5-1", "F1N6Y5-1", "A0AAA9TQW6-1", "A0A3Q1MLT2-1", "E1B8D6-1", "F1MHA1-1", "E1BLX2-1" ], "evidence": [ { "id": "R-BTA-8937050", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937050" } ] }, { "id": "R-BTA-9676264", "name": "Formation of the SET1B complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6Y5-1" ], "evidence": [ { "id": "R-BTA-9676264", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9676264" } ] }, { "id": "R-BTA-9821476", "name": "CXXC1 and WDR82 bind SET1B complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6Y5-1" ], "evidence": [ { "id": "R-BTA-9821476", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9821476" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MF12", "gene_name": "SETD3", "activity": [ { "ec_number": "2.1.1.85", "activity": "L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1MF12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF12" } ] }, { "ec_number": "2.1.1.85", "activity": "", "evidence": [ { "id": "A0A3Q1MF12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF12" } ] } ] }, { "uniprot_ac": "A0A3Q1MLT2", "gene_name": "KAT2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MLT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLT2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLT2" } ] } ] }, { "uniprot_ac": "A0AAA9RUH2", "gene_name": "SUV39H1", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "A0AAA9RUH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUH2" } ] } ] }, { "uniprot_ac": "A0AAA9TQW6", "gene_name": "KMT2C", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0AAA9TQW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQW6" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "A0AAA9TQW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQW6" } ] } ] }, { "uniprot_ac": "A0ABI0NZS0", "gene_name": "SETD7", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0ABI0NZS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZS0" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "A0ABI0NZS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZS0" } ] } ] }, { "uniprot_ac": "A0ABZ3NNC5", "gene_name": "PRMT1", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "A0ABZ3NNC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNC5" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "A0ABZ3NNC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNC5" } ] } ] }, { "uniprot_ac": "E1B8D6", "gene_name": "EP300", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "E1B8D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E1B8D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D6" } ] } ] }, { "uniprot_ac": "E1B906", "gene_name": "SETD4", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1B906", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B906" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "E1B906", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B906" } ] } ] }, { "uniprot_ac": "E1B9N8", "gene_name": "KMT2D", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8" } ] } ] }, { "uniprot_ac": "E1BKH5", "gene_name": "SETDB1", "activity": [ { "ec_number": "2.1.1.366", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1BKH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKH5" } ] }, { "ec_number": "2.1.1.366", "activity": "", "evidence": [ { "id": "E1BKH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKH5" } ] } ] }, { "uniprot_ac": "E1BKN0", "gene_name": "KMT2B", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1BKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKN0" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "E1BKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKN0" } ] } ] }, { "uniprot_ac": "E1BLX2", "gene_name": "SETD1A", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1BLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLX2" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "E1BLX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLX2" } ] } ] }, { "uniprot_ac": "F1MHA1", "gene_name": "KMT2A", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F1MHA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHA1" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "F1MHA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHA1" } ] } ] }, { "uniprot_ac": "F1MXG0", "gene_name": "SETDB2", "activity": [ { "ec_number": "2.1.1.366", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F1MXG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXG0" } ] }, { "ec_number": "2.1.1.366", "activity": "", "evidence": [ { "id": "F1MXG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXG0" } ] } ] }, { "uniprot_ac": "F1N6Y5", "gene_name": "SETD1B", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" } ] } ] }, { "uniprot_ac": "G3X834", "gene_name": "", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.355", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" }, { "id": "PS50868", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50868" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Post-SET", "eco_id": "ECO_0000259", "start_pos": 1950, "end_pos": 1966, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 181, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y5" }, { "id": "PS50280", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50280" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SET", "eco_id": "ECO_0000259", "start_pos": 1827, "end_pos": 1944, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.364", "ec_name": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.364", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364" }, { "id": "2.1.1.364", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.364" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 295, 385, 388, 560, 577, 665, 726, 1303, 1384 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1715, "end_pos": 1717 }, { "start_pos": 1765, "end_pos": 1767 }, { "start_pos": 1905, "end_pos": 1907 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 332, "end_pos": 334 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 9 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 9 }, { "field": "exact_o_linked_sites", "count": 9 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 9 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 9 }, { "field": "exact_o_linked_sites", "count": 9 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3J5-1", "uniprot_ac": "F1N3J5", "uniprot_id": "F1N3J5_BOVIN", "mass": { "chemical_mass": 66604.0, "monoisotopic_mass": 66604.0 }, "refseq": { "ac": "NP_001180021", "name": "bromodomain-containing protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180021" }, "gene_names": [ { "name": "BRD9", "type": "recommended", "evidence": [ { "id": "F1N3J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ] }, { "name": "BRD9", "type": "synonym", "evidence": [ { "id": "NP_001180021", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180021" } ] } ], "protein_names": [ { "name": "Bromodomain-containing protein 9", "type": "recommended", "evidence": [ { "id": "F1N3J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J5/entry#names_and_taxonomy" } ] }, { "name": "bromodomain-containing protein 9", "type": "synonym", "evidence": [ { "id": "NP_001180021", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180021" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRD9", "url": "https://www.uniprot.org/uniprotkb/F1N3J5", "locus": { "chromosome": "20", "start_pos": 71408911, "end_pos": 71390380, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006971", "url": "https://www.ensembl.org/id/ENSBTAG00000006971" } ] } } ], "crossref": [ { "id": "F1N3J5", "url": "https://alphafold.ebi.ac.uk/entry/F1N3J5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006971", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006971", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05513", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05513", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615865", "url": "https://www.ncbi.nlm.nih.gov/gene/615865", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615865", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615865", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEEDNPG", "url": "https://omabrowser.org/oma/group/MEEDNPG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3J5", "url": "https://www.orthodb.org/?gene=F1N3J5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22881", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22881", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22881:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22881:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9933947", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933947", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001180021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180021", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T8L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3J5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3J5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKKHKKHKTEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREKEHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIAANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAAEEPVPEVVPVHVETAKKSKRPSREVISCVFEPEGNACSLTDSTAEEHVLALVEHAADEARDRISRLVPGGKMGYLKKNGDGSLLYSVVNTAGLDADEEETHPVDLSSLSSKLLPGFTTLGFREERRSRVTFLSSASTALSTHNNSVFGDLKADEVELLYSAYGDETGVQCALSLQEFVKDAGSYSKKLVDDLLDQITGGDHSRMLFRLRQRRSVPMKPLDEVKAGDPLGDGSSTLDFMAMKPYSDVSLDISVLGCLGKVKKELDPEDGHLSLDETTKLLQDLQEAQAERGGSRPSSNLSSLSNASDRDQHHLGSPSRLSVGEQPEAAHDPYEFLQSPEPAVSTKP", "length": 596, "header": "tr|F1N3J5-1|F1N3J5_BOVIN Isoform 1 of Bromodomain-containing protein 9 OS=Bos taurus OX=9913 GN=BRD9 PE=4 SV=4 CANONICAL=F1N3J5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L9/entry", "sequence": { "sequence": "MGKKHKKHKTEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREKEHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPVSLNRVALVTGVTPRTLVPWWRRAFGTPHLGLWVQPWGHSGEDYILKCSCGGNLTELCSRSLEAVLPCCAARAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIAANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAAEEPVPEVVPVHVETAKKSKRPSREVISCVFEPEGNACSLTDSTAEEHVLALVEHAADEARDRISRLVPGGKMGYLKKNGDGSLLYSVVNTAGLDADEEETHPVDLSSLSSKLLPGFTTLGFREERRSRVTFLSSASTALSTHNNSVFGDLKADEVELLYSAYGDETGVQCALSLQEFVKDAGSYSKKLVDDLLDQITGGDHSRMLFRLRQRRSVPMKPLDEVKAGDPLGDGSSTLDFMAMKPYSDVSLDISVLGCLGKVKKELDPEDGHLSLDETTKLLQDLQEAQAERGGSRPSSNLSSLSNASDRDQHHLGSPSRLSVGEQPEAAHDPYEFLQSPEPAVSTKP", "length": 668, "header": "tr|A0AAA9T8L9-1|F1N3J5_BOVIN Computationally mapped isoform of Bromodomain-containing protein 9 OS=Bos taurus OX=9913 GN=BRD9 PE=4 SV=1 CANONICAL=F1N3J5-1" }, "locus": { "chromosome": "20", "start_pos": 71408356, "end_pos": 71390484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093956.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093956.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092220.1" } ] } }, { "isoform_ac": "F1N3J5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3J5/entry", "sequence": { "sequence": "MGKKHKKHKTEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREKEHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIAANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAAEEPVPEVVPVHVETAKKSKRPSREVISCVFEPEGNACSLTDSTAEEHVLALVEHAADEARDRISRLVPGGKMGYLKKNGDGSLLYSVVNTAGLDADEEETHPVDLSSLSSKLLPGFTTLGFREERRSRVTFLSSASTALSTHNNSVFGDLKADEVELLYSAYGDETGVQCALSLQEFVKDAGSYSKKLVDDLLDQITGGDHSRMLFRLRQRRSVPMKPLDEVKAGDPLGDGSSTLDFMAMKPYSDVSLDISVLGCLGKVKKELDPEDGHLSLDETTKLLQDLQEAQAERGGSRPSSNLSSLSNASDRDQHHLGSPSRLSVGEQPEAAHDPYEFLQSPEPAVSTKP", "length": 596, "header": "tr|F1N3J5-1|F1N3J5_BOVIN Isoform 1 of Bromodomain-containing protein 9 OS=Bos taurus OX=9913 GN=BRD9 PE=4 SV=4 CANONICAL=F1N3J5-1" }, "locus": { "chromosome": "20", "start_pos": 71408356, "end_pos": 71390484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048732.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048732.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045723.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045723.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615865", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615865", "resource": "KEGG Pathway" }, { "id": "R-BTA-9933947", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933947", "resource": "Reactome", "description": "Formation of the non-canonical BAF (ncBAF) complex" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XVB3-1", "protein_name": "Bromodomain-containing protein 9", "gene_name": "BRD9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGKKHKKHKADKAEWRSASTTSYSDYVDKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKEKHLDDEERRKRKEEKKRKREKEQCDTEGETDDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKEKIAANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHTGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGDEDTVVEEPVPEVMPVQVETTKKSKKQNKEVISCIFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRYLPNSKIGYLKKNGDGTLLFSVVNSSDPEAEEEETHPVDLSSLSSKFLPGFTTLGFKDERRNKVTFLTSASTALSMQNNSIFHDLKSEEMELLYSAYGDETGIQCALSLQEFVKDAGYYSKKIVDDLLDQITSGDHSKTVYQLKQRRNIPVKPLDEVKVLPVLIKEEHKLRNTCPDSSKQIMVGESAGDSNTSELDFLSMKSYSDVSLDISMLSSLGKVKKELDHDDNHLHLDETAKLLQDLHEAQADRVGSRPSSNLSSLSNTSERDQHHLGSPSHLSVGEQQDIVHDPYEFLQSPETSNATTN", "length": 650 }, "evidence": [ { "id": "F1N3J5", "url": "https://omabrowser.org/oma/group/F1N3J5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ACF5-1", "protein_name": "Bromodomain-containing protein 9", "gene_name": "Brd9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGLFTAHLPLRCKTSTWTAGDSATHGSACFRSPTASSMAPQPGAEEMRPARMRSRSPLGALWDSLLSCTKIHPGRVPDKSTSAARVARRLAIRPAPPSFESAARCAPPHPDPEALGGWRRNTSDWRRSGYGQPLLTGSRATSAMGKKHKKHKAEWRSSYEDYTDTPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHREKKKKKKKKSEKEKHLDEEERRKRKEEKKRKREKEHCDSEGEADAFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGSEDPAVEEPVPEVVPVQVETTKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKKLGDGSLLYSVVNATEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSASTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKMVDDLLDQITGGDHSRMIFQLKQRRSIPMRPADEMKVGDPLGDSGGPVLDFMSMKQYPDVSLDVSMLSSLGKVKKELDHEDSHLNLDETARLLQDLHEAQAERGGSRPSSNLSSLSTASEREQHPPGSPSRLSVGEQPDVTHDPYEFLQSPEPAAPAKN", "length": 761 }, "evidence": [ { "id": "F1N3J5", "url": "https://omabrowser.org/oma/group/F1N3J5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UQU0-1", "protein_name": "Bromodomain-containing protein 9", "gene_name": "Brd9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKKHKKHKAEWRSSYEDYTDTPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHREKKKKKKKKSEKEKHLDEEERRKRKEEKKRKREKEHCDSEGEADAFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKAALLGSEDPAAEEPVPEVVPVQVETTKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKKLGDGSLLYSVVNAPEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSASTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKMVDDLLDQITGGDHSRMIFQLKQRRSIPMRPADEMKVGDPLGESGGPVLDFMSMKQYPDVSLDVSMLSSLGKVKKELDHEDSHLNLDETARLLQDLHEAQAERGGSRPSSNLSSLSTASEREHPPPGSPSRLSVGEQPDVAHDPYEFLQSPEPAAPAKN", "length": 596 }, "evidence": [ { "id": "F1N3J5", "url": "https://omabrowser.org/oma/group/F1N3J5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H8M2-5", "protein_name": "Bromodomain-containing protein 9", "gene_name": "BRD9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT", "length": 597 }, "evidence": [ { "id": "F1N3J5", "url": "https://omabrowser.org/oma/group/F1N3J5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" }, { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "F1N3J5", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J5" }, { "id": "PS50014", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bromo", "eco_id": "ECO_0000259", "start_pos": 153, "end_pos": 223, "start_aa": "Gln", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 394, "end_pos": 396 }, { "start_pos": 548, "end_pos": 550 }, { "start_pos": 554, "end_pos": 556 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6R7-1", "uniprot_ac": "F1N6R7", "uniprot_id": "F1N6R7_BOVIN", "mass": { "chemical_mass": 65406.0, "monoisotopic_mass": 65406.0 }, "refseq": {}, "gene_names": [ { "name": "ACOXL", "type": "recommended", "evidence": [ { "id": "F1N6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ] } ], "protein_names": [ { "name": "Acyl-coenzyme A oxidase", "type": "recommended", "evidence": [ { "id": "F1N6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6R7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACOXL", "url": "https://www.uniprot.org/uniprotkb/F1N6R7", "locus": { "chromosome": "11", "start_pos": 1237715, "end_pos": 1576248, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004297", "url": "https://www.ensembl.org/id/ENSBTAG00000004297" } ] } } ], "crossref": [ { "id": "F1N6R7", "url": "https://alphafold.ebi.ac.uk/entry/F1N6R7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004297", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004297", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10909:SF352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10909:SF352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02770", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02770", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22924", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22924", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-389887", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389887", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZG0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZG0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2H7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2H7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2H7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2H7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6R7-1", "url": "https://www.uniprot.org/uniprotkb/F1N6R7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSRRQFGPKAREEVKIIEHQTQTLRLMPHLATALALTFASRYAGTLLDEDIFRGKELVDSRPLQALVAGLKAYSTWENVSCLQDCRECTGGMVVVRELLAQYTKQCEERPVSSLLRNWVESGSDRLRTSFLAFNMDTVGHLTFLLKAVHFRERILQRGLVARIYYKVMTEKEDFFSAWNSCLHHITCLSLAHIHRVTLEQFCLAVRNCPDQEDQDLLKQFCLLYGTKLVFQERAWYLEHKYLTPMTSMRIRRQLLHLCNSVKDDALRVISAFNISHASLHAPIAGFANPNAAWVLYPAPQHSLAGERARSPRPKLGAKL", "length": 580, "header": "tr|F1N6R7-1|F1N6R7_BOVIN Isoform 1 of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOXL PE=3 SV=2 CANONICAL=F1N6R7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ7/entry", "sequence": { "sequence": "MRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSRRQFGPKAREEVKIIEHQTQTLRLMPHLATALALTFASRYAGTLLDEDIFRGKELVDSRPLQALVAGLKAYSTWENVSCLQDCRECTGGMGYMMENQISGLKCDTDVFVTFEGDNVVMLQVVVRELLAQYTKQCEERPVSSLLRNWVESGSDRLRTSFLAFNMDTVGHLTFLLKAVHFRERILQRGLVARIYYKVMTEKEDFFSAWNSCLHHITCLSLAHIHRVTLEQFCLAVRNCPDQEDQDLLKQTSKEASQRRV", "length": 520, "header": "tr|A0A3Q1LWZ7-1|A0A3Q1LWZ7_BOVIN Computationally mapped isoform of Acyl-CoA oxidase like OS=Bos taurus OX=9913 GN=ACOXL PE=4 SV=3 CANONICAL=F1N6R7-1" }, "locus": { "chromosome": "11", "start_pos": 1550260, "end_pos": 1267074, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082299.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082299.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060012.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060012.3" } ] } }, { "isoform_ac": "A0AAA9TLL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLL1/entry", "sequence": { "sequence": "MEPADLGLGDSSLHRYLDGEFWSLKNELRGLLGGCPLFRPRYDLSLDEMRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSRRQFGPKAREEVKIIEHQTQTLRLMPHLATALALTFASRYAGTLLDEDIFRGKELVDSRPLQALVAGLKAYSTWENVSCLQDCRECTGGMGYMMENQISGLKCDTDVFVTFEGDNVVMLQVVVRELLAQYTKQCEERPVSSLLRNWVESGSDRLRTSFLAFNMDTVGHLTFLLKAVHFRERILQRGLVARIYYKVMTEKEDFFSAWNSCLHHITCLSLAHIHRVTLEQFCLAVRNCPDQEDQDLLKQFCLLYGTKLVFQERAWYLEHKYLTPMTSMRIRRQAWWYFVGGCNWNSVRQPQSTWK", "length": 614, "header": "tr|A0AAA9TLL1-1|F1N6R7_BOVIN Computationally mapped isoform of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOXL PE=3 SV=1 CANONICAL=F1N6R7-1" }, "locus": { "chromosome": "11", "start_pos": 1576166, "end_pos": 1261948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116191.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116191.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099336.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099336.1" } ] } }, { "isoform_ac": "A0AAA9TRQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRQ5/entry", "sequence": { "sequence": "MEPADLGLGDSSLHRYLDGEFWSLKNELRGLLGGCPLFRPRYDLSLDEMRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSASHNSQDVETT", "length": 322, "header": "tr|A0AAA9TRQ5-1|F1N6R7_BOVIN Computationally mapped isoform of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOXL PE=3 SV=1 CANONICAL=F1N6R7-1" }, "locus": { "chromosome": "11", "start_pos": 1576166, "end_pos": 1457949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110670.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110670.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099154.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099154.1" } ] } }, { "isoform_ac": "A0ABI0NZG0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZG0/entry", "sequence": { "sequence": "MRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSRRQFGPKAREEVKIIEHQTQTLRLMPHLATALALTFASRYAGTLLDEDIFRGKELVDSRPLQALVAGLKAYSTWENVSCLQDCRECTGGMGYMMENQISGLKCDTDVFVTFEGDNVVMLQVVVRELLAQYTKQCEERPVSSLLRNWVESGSDRLRTSFLAFNMDTVGHLTFLLKAVHFRERILQRGLVARIYYKVMTEKEDFFSAWNSCLHHITCLSLAHIHRVTLEQFCLAVRNCPDQEDQDLLKQFCLLYGTKLVFQERAWYLEHKYLTPMTSMRIRRQPIKSFCIFGKKAWWYFVGGCNWNSVRQPQSTWK", "length": 577, "header": "tr|A0ABI0NZG0-1|A0ABI0NZG0_BOVIN Computationally mapped isoform of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOXL PE=3 SV=1 CANONICAL=F1N6R7-1" }, "locus": { "chromosome": "11", "start_pos": 1550260, "end_pos": 1261948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150543.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150543.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107064.1" } ] } }, { "isoform_ac": "A0ABI0P2H7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2H7/entry", "sequence": { "sequence": "MEPADLGLGDSSLHRYLDGEFWSLKNELRGLLGGCPLFRPRYDLSLDEMRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSRRQFGPKAREEVKIIEHQTQTLRLMPHLATALALTFASRYAGTLLDEDIFRGKELVDSRPLQALVAGLKAYSTWENVSCLQDCRECTGGMGYMMENQISGLKCDTDVFVTFEGDNVVMLQVVVRELLAQYTKQCEERPVSSLLRNWVESGSDRLRTSFLAFNMDTVGHLTFLLKAVHFRERILQRGLVARIYYKVMTEKEDFFSAWNSCLHHITCLSLAHIHRVTLEQFCLAVRNCPDQEDQDLLKQFCLLYGTKLVFQERAWYLEHKYLTPMTSMRIRRQLLHLCNSVKDDALRVISAFNISHASLHAPIAGFA", "length": 626, "header": "tr|A0ABI0P2H7-1|A0ABI0P2H7_BOVIN Computationally mapped isoform of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOXL PE=3 SV=1 CANONICAL=F1N6R7-1" }, "locus": { "chromosome": "11", "start_pos": 1576166, "end_pos": 1238042, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141122.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141122.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105574.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105574.1" } ] } }, { "isoform_ac": "F1N6R7-1", "url": "https://www.uniprot.org/uniprotkb/F1N6R7/entry", "sequence": { "sequence": "MRTLTFQRVTFTMGLPLLKRAIQDQVEKTRNFVSRSLVIGEVLSMADMATGVKCGIIYWLFGGAIRSLGGPAHVTQWLQPLQEQKYTGMFAMTERGHGSNVRVIQTEATFDFSAQEFVIDTPCKNAEKMYIGNAMYGNYAAVFAQLIINGRSQGPHCFIVPVRDENGSLYPGVTVVDMMHKEGLHGVDNGILRFDSVRIPRENLLDKFGSVGPDGQYHSPIKDKSARFNAMLAALTPSRLAVTFQAMGSMKLGLTIAIRYSHSRRQFGPKAREEVKIIEHQTQTLRLMPHLATALALTFASRYAGTLLDEDIFRGKELVDSRPLQALVAGLKAYSTWENVSCLQDCRECTGGMVVVRELLAQYTKQCEERPVSSLLRNWVESGSDRLRTSFLAFNMDTVGHLTFLLKAVHFRERILQRGLVARIYYKVMTEKEDFFSAWNSCLHHITCLSLAHIHRVTLEQFCLAVRNCPDQEDQDLLKQFCLLYGTKLVFQERAWYLEHKYLTPMTSMRIRRQLLHLCNSVKDDALRVISAFNISHASLHAPIAGFANPNAAWVLYPAPQHSLAGERARSPRPKLGAKL", "length": 580, "header": "tr|F1N6R7-1|F1N6R7_BOVIN Isoform 1 of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOXL PE=3 SV=2 CANONICAL=F1N6R7-1" }, "locus": { "chromosome": "11", "start_pos": 1550260, "end_pos": 1237946, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033248.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033248.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033168.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033168.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-389887", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389887", "resource": "Reactome", "description": "Beta-oxidation of pristanoyl-CoA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation using acyl-CoA oxidase", "id": "GO:0033540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033540", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" }, { "name": "acyl-CoA oxidase activity", "id": "GO:0003997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003997", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" }, { "name": "fatty acid binding", "id": "GO:0005504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005504", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "F1N6R7", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" }, { "id": "PF22924", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22924" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA oxidase C-alpha1", "eco_id": "ECO_0000259", "start_pos": 234, "end_pos": 353, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" }, { "id": "PF01756", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01756" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA oxidase C-terminal", "eco_id": "ECO_0000259", "start_pos": 420, "end_pos": 545, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6R7" }, { "id": "PF02770", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02770" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA oxidase/dehydrogenase middle", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 197, "start_aa": "Phe", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 534, "end_pos": 536 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6C2-1", "uniprot_ac": "F1N6C2", "uniprot_id": "F1N6C2_BOVIN", "mass": { "chemical_mass": 26212.0, "monoisotopic_mass": 26212.0 }, "refseq": {}, "gene_names": [ { "name": "TMED4", "type": "recommended", "evidence": [ { "id": "F1N6C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ] } ], "protein_names": [ { "name": "Transmembrane p24 trafficking protein 4", "type": "synonym", "evidence": [ { "id": "F1N6C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMED4", "url": "https://www.uniprot.org/uniprotkb/F1N6C2", "locus": { "chromosome": "4", "start_pos": 76862564, "end_pos": 76859676, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010612", "url": "https://www.ensembl.org/id/ENSBTAG00000010612" } ] } } ], "crossref": [ { "id": "F1N6C2", "url": "https://alphafold.ebi.ac.uk/entry/F1N6C2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010612", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010612", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR009038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N6C2", "url": "https://www.orthodb.org/?gene=F1N6C2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22811", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22811", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TQ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSM9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSM9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6C2-1", "url": "https://www.uniprot.org/uniprotkb/F1N6C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGVWAGRRRAMGLPALLLLALCAASARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPEGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGRLRVHLDIQVGEHTNNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLISESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV", "length": 227, "header": "tr|F1N6C2-1|F1N6C2_BOVIN Isoform 1 of Transmembrane p24 trafficking protein 4 OS=Bos taurus OX=9913 GN=TMED4 PE=3 SV=4 CANONICAL=F1N6C2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TQ06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ06/entry", "sequence": { "sequence": "MAGVWAGRRRAMGLPALLLLALCAASARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPEGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGRLYREERFRLISESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV", "length": 178, "header": "tr|A0AAA9TQ06-1|F1N6C2_BOVIN Computationally mapped isoform of Transmembrane p24 trafficking protein 4 OS=Bos taurus OX=9913 GN=TMED4 PE=3 SV=2 CANONICAL=F1N6C2-1" }, "locus": { "chromosome": "4", "start_pos": 76861560, "end_pos": 76859718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094565.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094565.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100649.1" } ] } }, { "isoform_ac": "A0ABI0NSM9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSM9/entry", "sequence": { "sequence": "MAGVWAGRRRAMGLPALLLLALCAASARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPEGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGRLRVHLDIQVGEHTNNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRVRACHVLG", "length": 186, "header": "tr|A0ABI0NSM9-1|A0ABI0NSM9_BOVIN Computationally mapped isoform of Transmembrane p24 trafficking protein 4 OS=Bos taurus OX=9913 GN=TMED4 PE=3 SV=1 CANONICAL=F1N6C2-1" }, "locus": { "chromosome": "4", "start_pos": 76860995, "end_pos": 76859718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151030.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151030.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107124.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107124.1" } ] } }, { "isoform_ac": "F1N6C2-1", "url": "https://www.uniprot.org/uniprotkb/F1N6C2/entry", "sequence": { "sequence": "MAGVWAGRRRAMGLPALLLLALCAASARGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPEGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGRLRVHLDIQVGEHTNNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLISESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV", "length": 227, "header": "tr|F1N6C2-1|F1N6C2_BOVIN Isoform 1 of Transmembrane p24 trafficking protein 4 OS=Bos taurus OX=9913 GN=TMED4 PE=3 SV=4 CANONICAL=F1N6C2-1" }, "locus": { "chromosome": "4", "start_pos": 76861560, "end_pos": 76859718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014027.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014027.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014027.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014027.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" }, { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "F1N6C2", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C2" }, { "id": "PS50866", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GOLD", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 137, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4E2-1", "uniprot_ac": "F1N4E2", "uniprot_id": "F1N4E2_BOVIN", "mass": { "chemical_mass": 27551.0, "monoisotopic_mass": 27551.0 }, "refseq": {}, "gene_names": [ { "name": "CD27", "type": "recommended", "evidence": [ { "id": "F1N4E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ] } ], "protein_names": [ { "name": "CD27 antigen", "type": "recommended", "evidence": [ { "id": "F1N4E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E2/entry#names_and_taxonomy" } ] }, { "name": "CD27L receptor", "type": "synonym", "evidence": [ { "id": "F1N4E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E2/entry#names_and_taxonomy" } ] }, { "name": "T-cell activation antigen CD27", "type": "synonym", "evidence": [ { "id": "F1N4E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E2/entry#names_and_taxonomy" } ] }, { "name": "Tumor necrosis factor receptor superfamily member 7", "type": "synonym", "evidence": [ { "id": "F1N4E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TST6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TST6#function" }, { "database": "UniProtKB", "id": "ARBA00058746", "url": "https://www.uniprot.org/uniprotkb/ARBA00058746#function" }, { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD27", "url": "https://www.uniprot.org/uniprotkb/F1N4E2", "locus": { "chromosome": "5", "start_pos": 103931998, "end_pos": 103937571, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014725", "url": "https://www.ensembl.org/id/ENSBTAG00000014725" } ] } } ], "crossref": [ { "id": "F1N4E2", "url": "https://alphafold.ebi.ac.uk/entry/F1N4E2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014725", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014725", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13408", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13408", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LSTHWSP", "url": "https://omabrowser.org/oma/group/LSTHWSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4E2", "url": "https://www.orthodb.org/?gene=F1N4E2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47496", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47496", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47496:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47496:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TST6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TST6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TST6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TST6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4E2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4E2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARLPPCWLWVLGTLAGLSATPDPKSCPEKHYWAQGGWCCQMCEPGTFLVKDCEQHREAAQCNPCTPGVSFMPDHHSRPHCESCRHCNSGLLIRNCTLTANSECACPEGQQCRDKDCMECDGPAQAPGPHPQPSHLPYAEEIAESRTDRHTQTLANSRWLPAPTLSTHWSPQRSLCSANCIRIFVLLSGMFLAFTIVGALFLHQQRKLNAGESPVAPAEPCPYTCPSEEEGSAIPIQEDYRKPEPTSYF", "length": 249, "header": "tr|F1N4E2-1|F1N4E2_BOVIN Isoform 1 of CD27 antigen OS=Bos taurus OX=9913 GN=CD27 PE=4 SV=2 CANONICAL=F1N4E2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TST6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TST6/entry", "sequence": { "sequence": "MARLPPCWLWVLGTLAGLSATPDPKSCPEKHYWAQGGWCCQMCEPGTFLVKDCEQHREAAQCNPCTPGVSFMPDHHSRPHCESCRHCNSGLLIRNCTLTANSECACPEGQQCRDKDCMECDGPAQAPGPHPQPSHLPYAEEIAESRTDRHTQTLANSRWLPAPTLSTHWSRDSSPIPSGGTKIPHATEQQRPNIAKTQRSLCSANCIRIFVLLSGMFLAFTIVGALFLHQQRKLNAGESPVAPAEPCPYTCPSEEEGSAIPIQEDYRKPEPTSYF", "length": 275, "header": "tr|A0AAA9TST6-1|F1N4E2_BOVIN Computationally mapped isoform of CD27 antigen OS=Bos taurus OX=9913 GN=CD27 PE=4 SV=1 CANONICAL=F1N4E2-1" }, "locus": { "chromosome": "5", "start_pos": 103937219, "end_pos": 103932655, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119414.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119414.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100411.1" } ] } }, { "isoform_ac": "F1N4E2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4E2/entry", "sequence": { "sequence": "MARLPPCWLWVLGTLAGLSATPDPKSCPEKHYWAQGGWCCQMCEPGTFLVKDCEQHREAAQCNPCTPGVSFMPDHHSRPHCESCRHCNSGLLIRNCTLTANSECACPEGQQCRDKDCMECDGPAQAPGPHPQPSHLPYAEEIAESRTDRHTQTLANSRWLPAPTLSTHWSPQRSLCSANCIRIFVLLSGMFLAFTIVGALFLHQQRKLNAGESPVAPAEPCPYTCPSEEEGSAIPIQEDYRKPEPTSYF", "length": 249, "header": "tr|F1N4E2-1|F1N4E2_BOVIN Isoform 1 of CD27 antigen OS=Bos taurus OX=9913 GN=CD27 PE=4 SV=2 CANONICAL=F1N4E2-1" }, "locus": { "chromosome": "5", "start_pos": 103937219, "end_pos": 103932655, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019595.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019595.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019595.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019595.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5669034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "resource": "Reactome", "description": "TNFs bind their physiological receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P26842-1", "protein_name": "CD27 antigen", "gene_name": "CD27", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYRSNKGESPVEPAEPCHYSCPREEEGSTIPIQEDYRKPEPACSP", "length": 260 }, "evidence": [ { "id": "F1N4E2", "url": "https://omabrowser.org/oma/group/F1N4E2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41272-1", "protein_name": "CD27 antigen", "gene_name": "Cd27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAWPPPYWLCMLGTLVGLSATLAPNSCPDKHYWTGGGLCCRMCEPGTFFVKDCEQDRTAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANAECSCSKNWQCRDQECTECDPPLNPALTRQPSETPSPQPPPTHLPHGTEKPSWPLHRQLPNSTVYSQRSSHRPLCSSDCIRIFVTFSSMFLIFVLGAILFFHQRRNHGPNEDRQAVPEEPCPYSCPREEEGSAIPIQEDYRKPEPAFYP", "length": 250 }, "evidence": [ { "id": "F1N4E2", "url": "https://omabrowser.org/oma/group/F1N4E2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "id": "GO:0043027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043027", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "T cell activation", "id": "GO:0042110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042110", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "positive regulation of B cell differentiation", "id": "GO:0045579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045579", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "positive regulation of T cell differentiation", "id": "GO:0045582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045582", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "adaptive immune memory response involving T cells and B cells", "id": "GO:0090717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090717", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "CD27 signaling pathway", "id": "GO:0160162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160162", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N4E2", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E2" }, { "id": "PS50050", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50050" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TNFR-Cys", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 104, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2V3-1", "uniprot_ac": "F1N2V3", "uniprot_id": "F1N2V3_BOVIN", "mass": { "chemical_mass": 44503.0, "monoisotopic_mass": 44503.0 }, "refseq": {}, "gene_names": [ { "name": "GNA15", "type": "recommended", "evidence": [ { "id": "F1N2V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ] } ], "protein_names": [ { "name": "Guanine nucleotide-binding protein subunit alpha", "type": "recommended", "evidence": [ { "id": "F1N2V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2V3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3#function" }, { "database": "UniProtKB", "id": "RU369122", "url": "https://www.uniprot.org/uniprotkb/RU369122#function" } ] }, { "annotation": "Member of the G-protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses.", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3#function" }, { "database": "UniProtKB", "id": "ARBA00094124", "url": "https://www.uniprot.org/uniprotkb/ARBA00094124#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNA15", "url": "https://www.uniprot.org/uniprotkb/F1N2V3", "locus": { "chromosome": "7", "start_pos": 20660318, "end_pos": 20685281, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019988", "url": "https://www.ensembl.org/id/ENSBTAG00000019988" } ] } } ], "crossref": [ { "id": "F1N2V3", "url": "https://alphafold.ebi.ac.uk/entry/F1N2V3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019988", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019988", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00066", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00066", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N2V3", "url": "https://www.orthodb.org/?gene=F1N2V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218:SF217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218:SF217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00503", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00503", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TSV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2V3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARSLTWRCCPWCLTEDEKSAARIDQEINKILLEQKKRDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEDRKNFRPLVYQNIFISMRSMIEAMERLQIPFSWPESKHHASVIMSQDPYKVTKFEKRHAVAMQWLWEDTGIRACYERRREFHLLDSAVYYLSNLDRITEEGYIPTAQDVLRSRMPTTGINEYCFSVQKTNLRRWFPRRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFRGPKQDAEAAKKFILDMYTRMYAGCVDGADGGRKGPRSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL", "length": 380, "header": "tr|F1N2V3-1|F1N2V3_BOVIN Isoform 1 of Guanine nucleotide-binding protein subunit alpha OS=Bos taurus OX=9913 GN=GNA15 PE=3 SV=2 CANONICAL=F1N2V3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TSV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSV9/entry", "sequence": { "sequence": "MARSLTWRCCPWCLTEDEKSAARIDQEINKILLEQKKRDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEDRKNFRPLVYQNIFISMRSMIEAMERLQIPFSWPESKHHASVIMSQDPYKVTKFEKRHAVAMQWLWEDTGIRACYERRREFHLLDSAVYYLSNLDRITEEGYIPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFRVGSFESRPKQSPHVAFGCCSVQSLSHVRLIGTPRTVACQAPLSLKFSRQEHWSGLPFPSSGDLPDSGIEPMSLASPALAGGFFTTAPLGNPLGFSIS", "length": 396, "header": "tr|A0AAA9TSV9-1|F1N2V3_BOVIN Computationally mapped isoform of Guanine nucleotide-binding protein subunit alpha OS=Bos taurus OX=9913 GN=GNA15 PE=3 SV=1 CANONICAL=F1N2V3-1" }, "locus": { "chromosome": "7", "start_pos": 20684912, "end_pos": 20661322, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113830.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113830.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100431.1" } ] } }, { "isoform_ac": "F1N2V3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2V3/entry", "sequence": { "sequence": "MARSLTWRCCPWCLTEDEKSAARIDQEINKILLEQKKRDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEDRKNFRPLVYQNIFISMRSMIEAMERLQIPFSWPESKHHASVIMSQDPYKVTKFEKRHAVAMQWLWEDTGIRACYERRREFHLLDSAVYYLSNLDRITEEGYIPTAQDVLRSRMPTTGINEYCFSVQKTNLRRWFPRRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFRGPKQDAEAAKKFILDMYTRMYAGCVDGADGGRKGPRSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL", "length": 380, "header": "tr|F1N2V3-1|F1N2V3_BOVIN Isoform 1 of Guanine nucleotide-binding protein subunit alpha OS=Bos taurus OX=9913 GN=GNA15 PE=3 SV=2 CANONICAL=F1N2V3-1" }, "locus": { "chromosome": "7", "start_pos": 20684912, "end_pos": 20666147, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026624.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026624.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026624.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026624.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "G-protein beta/gamma-subunit complex binding", "id": "GO:0031683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031683", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "phospholipase C-activating dopamine receptor signaling pathway", "id": "GO:0060158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060158", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" }, { "name": "heterotrimeric G-protein complex", "id": "GO:0005834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005834", "evidence": [ { "database": "UniProtKB", "id": "F1N2V3", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "F1N2V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" }, { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 189, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 189, "end_pos": 189, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2V3" }, { "id": "PIRSR601019-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601019-2" } ], "binding_site_uniprot": 56, "amino_acid": "Ser", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 56, "end_pos": 56, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QNK2-1", "uniprot_ac": "F6QNK2", "uniprot_id": "F6QNK2_BOVIN", "mass": { "chemical_mass": 103973.0, "monoisotopic_mass": 103973.0 }, "refseq": {}, "gene_names": [ { "name": "SLC4A1", "type": "recommended", "evidence": [ { "id": "F6QNK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ] } ], "protein_names": [ { "name": "Anion exchange protein", "type": "recommended", "evidence": [ { "id": "F6QNK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNK2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2#function" }, { "database": "UniProtKB", "id": "ARBA00059376", "url": "https://www.uniprot.org/uniprotkb/ARBA00059376#function" }, { "database": "UniProtKB", "id": "A0A3Q1MR36", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR36#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC4A1", "url": "https://www.uniprot.org/uniprotkb/F6QNK2", "locus": { "chromosome": "19", "start_pos": 44066249, "end_pos": 44082466, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001610", "url": "https://www.ensembl.org/id/ENSBTAG00000001610" } ] } } ], "crossref": [ { "id": "F6QNK2", "url": "https://alphafold.ebi.ac.uk/entry/F6QNK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001610", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001610", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MR36", "url": "https://www.orthodb.org/?gene=A0A3Q1MR36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11453:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00955", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00955", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07565", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07565", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "72363", "url": "https://www.rhea-db.org/rhea/72363", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MR36", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QNK2-1", "url": "https://www.uniprot.org/uniprotkb/F6QNK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QEYEDQLEETLEQKEYEDHDSVSIPMEEAEGDTIQEEEAEARVNQLTDTDYHTTSQHPETHKVCVQLRELVMDEKNQEIQWMETARWVGLEENLGKDGIWGRPHLPYLNFWSLLELQKAFAKGTVLLDLPGKSLAEVANQLLDRFTFEGQIQPDDQDNLLRVLLLKHSHASDMEALGGVKPVVVTHSGDPSEPLLPQHPSLETELFCEQGEGSTRGHAPEILGKSPQDWEATLVLVGCARFLKRPVLGFVRLKEPMEPEPKPEGSEEPAVPVRFLIVLLGPEGPNINYTQLGRAAATLMSERVFWNDAYLAQSKETLVQSLEGFLDCSLVLPPLDAPSEKALLSLVPVQKELLRRRYLPSPAKPDPSIFKDLDVKKGPGDTPEDPLQRTGKLFGGLVRDIRRRYPRYLSDITDALSPQVLSAIIFIYFAALTPAITFGGLLGDKTENMIGVSELLLSTALQGIIFSLLGAQPLLVLGFSGPLLVFEEAFYSFCQTNNLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFYKLVTIFQDHPLQKNYDHDVLTTPKPQAALPNTALLSLVLMAGTFFLAMMLRKFKNSSYFPGKLRRIIGDFGVPISILIMVMVDALIQDTYTQKLSVPEGLSVSNPTERDWLIHPLGIRVEFPIWMMFASALPALLVFILIFLESQITTLIISKPERKMVKGSGFHLDLLLIIGMGGVGAIFGMPWLSATTVRTVTHANALTVMSKDSTPGAVSQIQGVKEQRISGLLVAVLVGVSILMGPVLRHIPLAVLFGIFLYMGVTSLSGIQLFDRVLLLLKPRKYYPEVPYARRVKTWRMHLFTITQIVCLVVLWVVRSIKQISLALPFILILTVPLRRFLLPFIFRDMELKLLDADDVKLNLDEQNGQDEYDEVAMPV", "length": 926, "header": "tr|F6QNK2-1|F6QNK2_BOVIN Isoform 1 of Anion exchange protein OS=Bos taurus OX=9913 GN=SLC4A1 PE=3 SV=1 CANONICAL=F6QNK2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MR36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR36/entry", "sequence": { "sequence": "MGDPEEYEDQLEETLEQKEYEDHDSVSIPMEEAEGDTIQEEEAEARVNQLTDTDYHTTSQHPETHKVCVQLRELVMDEKNQEIQWMETARWVGLEENLGKDGIWGRPHLPYLNFWSLLELQKAFAKGTVLLDLPGKSLAEVANQLLDRFTFEGQIQPDDQDNLLRVLLLKHSHASDMEALGGVKPVVVTHSGDPSEPLLPQHPSLETELFCEQGEGSTRGHAPEILGKSPQDWEATLVLVGCARFLKRPVLGFVRLKEPMEPEPKPEGSEEPAVPVRFLIVLLGPEGPNINYTQLGRAAATLMSERVFWNDAYLAQSKETLVQSLEGFLDCSLVLPPLDAPSEKALLSLVPVQKELLRRRYLPSPAKPDPSIFKDLDVKKGPGDTPEDPLQRTGKLFGGLVRDIRRRYPRYLSDITDALSPQVLSAIIFIYFAALTPAITFGGLLGDKTENMIGVSELLLSTALQGIIFSLLGAQPLLVLGFSGPLLVFEEAFYSFCQTNNLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFYKLVTIFQDHPLQKNYDHDVLTTPKPQAALPNTALLSLVLMAGTFFLAMMLRKFKNSSYFPGKKLSVPEGLSVSNPTERDWLIHPLGIRVEFPIWMMFASALPALLVFILIFLESQITTLIISKPERKMVKGSGFHLDLLLIIGMGGVGAIFGMPWLSATTVRTVTHANALTVMSKDSTPGAVSQIQGVKEQRISGLLVAVLVGVSILMGPVLRHIPLAVLFGIFLYMGVTSLSGIQLFDRVLLLLKPRKYYPEVPYARRVKTWRMHLFTITQIVCLVVLWVVRSIKQISLALPFILILTVPLRRFLLPFIFRDMELKLLDADDVKLNLDEQNGQDEYDEVAMPV", "length": 900, "header": "tr|A0A3Q1MR36-1|F6QNK2_BOVIN Computationally mapped isoform of Anion exchange protein OS=Bos taurus OX=9913 GN=SLC4A1 PE=3 SV=1 CANONICAL=F6QNK2-1" }, "locus": { "chromosome": "19", "start_pos": 44077609, "end_pos": 44066771, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077641.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077641.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074146.1" } ] } }, { "isoform_ac": "F6QNK2-1", "url": "https://www.uniprot.org/uniprotkb/F6QNK2/entry", "sequence": { "sequence": "QEYEDQLEETLEQKEYEDHDSVSIPMEEAEGDTIQEEEAEARVNQLTDTDYHTTSQHPETHKVCVQLRELVMDEKNQEIQWMETARWVGLEENLGKDGIWGRPHLPYLNFWSLLELQKAFAKGTVLLDLPGKSLAEVANQLLDRFTFEGQIQPDDQDNLLRVLLLKHSHASDMEALGGVKPVVVTHSGDPSEPLLPQHPSLETELFCEQGEGSTRGHAPEILGKSPQDWEATLVLVGCARFLKRPVLGFVRLKEPMEPEPKPEGSEEPAVPVRFLIVLLGPEGPNINYTQLGRAAATLMSERVFWNDAYLAQSKETLVQSLEGFLDCSLVLPPLDAPSEKALLSLVPVQKELLRRRYLPSPAKPDPSIFKDLDVKKGPGDTPEDPLQRTGKLFGGLVRDIRRRYPRYLSDITDALSPQVLSAIIFIYFAALTPAITFGGLLGDKTENMIGVSELLLSTALQGIIFSLLGAQPLLVLGFSGPLLVFEEAFYSFCQTNNLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFYKLVTIFQDHPLQKNYDHDVLTTPKPQAALPNTALLSLVLMAGTFFLAMMLRKFKNSSYFPGKLRRIIGDFGVPISILIMVMVDALIQDTYTQKLSVPEGLSVSNPTERDWLIHPLGIRVEFPIWMMFASALPALLVFILIFLESQITTLIISKPERKMVKGSGFHLDLLLIIGMGGVGAIFGMPWLSATTVRTVTHANALTVMSKDSTPGAVSQIQGVKEQRISGLLVAVLVGVSILMGPVLRHIPLAVLFGIFLYMGVTSLSGIQLFDRVLLLLKPRKYYPEVPYARRVKTWRMHLFTITQIVCLVVLWVVRSIKQISLALPFILILTVPLRRFLLPFIFRDMELKLLDADDVKLNLDEQNGQDEYDEVAMPV", "length": 926, "header": "tr|F6QNK2-1|F6QNK2_BOVIN Isoform 1 of Anion exchange protein OS=Bos taurus OX=9913 GN=SLC4A1 PE=3 SV=1 CANONICAL=F6QNK2-1" }, "locus": { "chromosome": "19", "start_pos": 44077484, "end_pos": 44066771, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002116.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002116.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002116.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002116.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 381, "start_aa": "Thr", "end_pos": 381, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr381", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "cortical cytoskeleton", "id": "GO:0030863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030863", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "ankyrin-1 complex", "id": "GO:0170014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170014", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "monoatomic anion transmembrane transporter activity", "id": "GO:0008509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008509", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "cytoskeletal protein binding", "id": "GO:0008092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "solute:inorganic anion antiporter activity", "id": "GO:0005452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005452", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "hemoglobin binding", "id": "GO:0030492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030492", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "ankyrin binding", "id": "GO:0030506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" }, { "name": "chloride:bicarbonate antiporter activity", "id": "GO:0140900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140900", "evidence": [ { "database": "UniProtKB", "id": "F6QNK2", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 607, "end_pos": 609, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72363", "name": "", "equation": "hydrogencarbonate(in) + chloride(out) = hydrogencarbonate(out) + chloride(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72363", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72363" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QNK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" }, { "id": "PF07565", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07565" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Band 3 cytoplasmic", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 337, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6QNK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QNK2" }, { "id": "PF00955", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00955" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bicarbonate transporter-like transmembrane", "eco_id": "ECO_0000259", "start_pos": 391, "end_pos": 566, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 381 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 287, "end_pos": 289 }, { "start_pos": 607, "end_pos": 609 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6T0-1", "uniprot_ac": "F1N6T0", "uniprot_id": "F1N6T0_BOVIN", "mass": { "chemical_mass": 103590.0, "monoisotopic_mass": 103590.0 }, "refseq": { "ac": "XP_024834683", "name": "zinc finger protein ZFPM1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834683" }, "gene_names": [ { "name": "ZFPM1", "type": "recommended", "evidence": [ { "id": "F1N6T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ] }, { "name": "ZFPM1", "type": "synonym", "evidence": [ { "id": "XP_024834683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834683" } ] } ], "protein_names": [ { "name": "Zinc finger protein ZFPM1", "type": "recommended", "evidence": [ { "id": "F1N6T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T0/entry#names_and_taxonomy" } ] }, { "name": "Friend of GATA protein 1", "type": "synonym", "evidence": [ { "id": "F1N6T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T0/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein multitype 1", "type": "synonym", "evidence": [ { "id": "F1N6T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T0/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein ZFPM1", "type": "synonym", "evidence": [ { "id": "XP_024834683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834683" } ] } ], "function": [ { "annotation": "Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.", "evidence": [ { "database": "UniProtKB", "id": "G3MWI7", "url": "https://www.uniprot.org/uniprotkb/G3MWI7#function" }, { "database": "UniProtKB", "id": "ARBA00059605", "url": "https://www.uniprot.org/uniprotkb/ARBA00059605#function" }, { "database": "UniProtKB", "id": "A0AAA9T654", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T654#function" }, { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFPM1", "url": "https://www.uniprot.org/uniprotkb/F1N6T0", "locus": { "chromosome": "18", "start_pos": 13782410, "end_pos": 13719997, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015766", "url": "https://www.ensembl.org/id/ENSBTAG00000015766" } ] } } ], "crossref": [ { "id": "F1N6T0", "url": "https://alphafold.ebi.ac.uk/entry/F1N6T0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015766", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015766", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528338", "url": "https://www.ncbi.nlm.nih.gov/gene/528338", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528338", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528338", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DCGIWFR", "url": "https://omabrowser.org/oma/group/DCGIWFR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6T0", "url": "https://www.orthodb.org/?gene=F1N6T0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12958:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12958:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21182", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21182", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8936459", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936459", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024834683", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834683", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T654", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T654", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T654-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T654-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6T0-1", "url": "https://www.uniprot.org/uniprotkb/F1N6T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWI7", "url": "https://www.uniprot.org/uniprotkb/G3MWI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWI7-1", "url": "https://www.uniprot.org/uniprotkb/G3MWI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRKQSNPRQIKRSLGDMEAKEEAQAADTSLPEREATAVEPEPTSPSSPDANPPPPPLPPAPTSPGGPEEPEHREPEMRPEEEAASSPWSGPDELEPLLQDGQRCVQARCSLTEGLSWGPFRGSIQTRASSPGQAELSPALTLLLEDEACWLRTLPQPLAEAEANAEIYRKDEALWCRLTRPVPAGGQLKVLLVAKPPSNPSHPVKKEPAEPESPAPSHPDIQLLPQQAGMASILATAVVNKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGAGSPAVATLDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLTGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKAEIYSPGTGHPTAKLPTDSLAAFHQHTALHGPLASADLGLAPAPSPGVDRKALAEATNGESRAGPQNGGGGDPPAAPRSIKVEAAEEPEAEPGPLAPSRTPSPPSPGPARVKAELSSPTPGSSPGPSALFLPHLPAAPPASEILAKMSELVHSRLQAGTGLGAPTGLFAGAPKGATCFECDITFNNVNNFYVHKRLYCSGRRPPDDVPPARRPKAAPAPPRVPPAPPSSEAEAPRSSPGPGAREDEAGSAATPEADADASGRGSEGSPSPGSGADEDDDPRRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAPAGTPAPSAPPVRSRRRRKLYELHAAGPAPPLAGPAPPLAGPAPPSAPGSAPTPPGPAPTPPASPRPGSGSGQEAAEGPIDLSKKPRRQAPAAAPGPAPGLAALADYHECTACRVSFHSLEAYLAHKKFSCPAAPRRLRAAPEDPPAVVCPYCPPNGVVRGDLIEHFRLAHGLLLGKPLVGPGAEARTPSPAAPRDGLNGQDLQEPPASSPRPGPPPAASPEAVPTPPSYSDKGVQTPSQGAPAPVPNGNHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK", "length": 986, "header": "tr|F1N6T0-1|F1N6T0_BOVIN Isoform 1 of Zinc finger protein ZFPM1 OS=Bos taurus OX=9913 GN=ZFPM1 PE=4 SV=2 CANONICAL=F1N6T0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T654-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T654/entry", "sequence": { "sequence": "MEAKEEAQAADTSLPEREATAVEPEPTSPSSPDANPPPPPLPPAPTSPGGPEEPEHREPEMRPEEEAASSPWSGPDELEPLLQDGQRCVQARCSLTEGLSWGPFRGSIQTRASSPGQAELSPALTLLLEDEACWLRTLPQPLAEAEANAEIYRKDEALWCRLTRPVPAGGQLKVLLVAKPPSNPSHPVKKEPAEPESPAPSHPDIQLLPQQAGMASILATAVVNKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGAGSPAVATLDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLTGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKAEIYSPGTGHPTAKLPTDSLAAFHQHTALHGPLASADLGLAPAPSPGVDRKALAEATNGESRAGPQNGGGGDPPAAPRSIKVEAAEEPEAEPGPLAPSRTPSPPSPGPARVKAELSSPTPGSSPGPSALFLPHLPAAPPASEILAKMSELVHSRLQAGTGLGAPTGLFAGAPKGATCFECDITFNNVNNFYVHKRLYCSGRRPPDDVPPARRPKAAPAPPRVPPAPPSSEAEAPRSSPGPGAREDEAGSAATPEADADASGRGSEGSPSPGSGADEDDDPRRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAPAGTPAPSAPPVRSRRRRKLYELHAAGPAPPLAGPAPPLAGPAPPSAPGSAPTPPGPAPTPPASPRPGSGSGQEAAEGPIDLSKKPRRQAPAAAPGPAPGLAALADYHECTACRVSFHSLEAYLAHKKFSCPAAPRRLRAAPEDPPAVVCPYCPPNGVVRGDLIEHFRLAHGLLLGKPLVGPGAEARTPSPAAPRDGLNGQDLQEPPASSPRPGPPPAASPEAVPTPPSYSDKGVQTPSQGAPAPVPNGNHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK", "length": 968, "header": "tr|A0AAA9T654-1|F1N6T0_BOVIN Computationally mapped isoform of Zinc finger protein ZFPM1 OS=Bos taurus OX=9913 GN=ZFPM1 PE=4 SV=1 CANONICAL=F1N6T0-1" }, "locus": { "chromosome": "18", "start_pos": 13781406, "end_pos": 13744410, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101462.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101462.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093347.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093347.1" } ] } }, { "isoform_ac": "F1N6T0-1", "url": "https://www.uniprot.org/uniprotkb/F1N6T0/entry", "sequence": { "sequence": "MSRRKQSNPRQIKRSLGDMEAKEEAQAADTSLPEREATAVEPEPTSPSSPDANPPPPPLPPAPTSPGGPEEPEHREPEMRPEEEAASSPWSGPDELEPLLQDGQRCVQARCSLTEGLSWGPFRGSIQTRASSPGQAELSPALTLLLEDEACWLRTLPQPLAEAEANAEIYRKDEALWCRLTRPVPAGGQLKVLLVAKPPSNPSHPVKKEPAEPESPAPSHPDIQLLPQQAGMASILATAVVNKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGAGSPAVATLDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLTGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKAEIYSPGTGHPTAKLPTDSLAAFHQHTALHGPLASADLGLAPAPSPGVDRKALAEATNGESRAGPQNGGGGDPPAAPRSIKVEAAEEPEAEPGPLAPSRTPSPPSPGPARVKAELSSPTPGSSPGPSALFLPHLPAAPPASEILAKMSELVHSRLQAGTGLGAPTGLFAGAPKGATCFECDITFNNVNNFYVHKRLYCSGRRPPDDVPPARRPKAAPAPPRVPPAPPSSEAEAPRSSPGPGAREDEAGSAATPEADADASGRGSEGSPSPGSGADEDDDPRRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAPAGTPAPSAPPVRSRRRRKLYELHAAGPAPPLAGPAPPLAGPAPPSAPGSAPTPPGPAPTPPASPRPGSGSGQEAAEGPIDLSKKPRRQAPAAAPGPAPGLAALADYHECTACRVSFHSLEAYLAHKKFSCPAAPRRLRAAPEDPPAVVCPYCPPNGVVRGDLIEHFRLAHGLLLGKPLVGPGAEARTPSPAAPRDGLNGQDLQEPPASSPRPGPPPAASPEAVPTPPSYSDKGVQTPSQGAPAPVPNGNHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK", "length": 986, "header": "tr|F1N6T0-1|F1N6T0_BOVIN Isoform 1 of Zinc finger protein ZFPM1 OS=Bos taurus OX=9913 GN=ZFPM1 PE=4 SV=2 CANONICAL=F1N6T0-1" }, "locus": { "chromosome": "18", "start_pos": 13781406, "end_pos": 13720196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047968.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047968.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045114.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045114.3" } ] } }, { "isoform_ac": "G3MWI7-1", "url": "https://www.uniprot.org/uniprotkb/G3MWI7/entry", "sequence": { "sequence": "MPTSASSAIAALIGLTSSSCGTGPGAHPRHILRLWKPECSLGDMEAKEEAQAADTSLPEREATAVEPEPTSPSSPDANPPPPPLPPAPTSPGGPEEPEHREPEMRPEEEAASSPWSGPDELEPLLQDGQRCVQARCSLTEGLSWGPFRGSIQTRASSPGQAELSPALTLLLEDEACWLRTLPQPLAEAEANAEIYRKDEALWCRLTRPVPAGGQLKVLLVAKPPSNPSHPVKKEPAEPESPAPSHPDIQLLPQQAGMASILATAVVNKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGAGSPAVATLDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLTGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKAEIYSPGTGHPTAKLPTDSLAAFHQHTALHGPLASADLGLAPAPSPGVDRKALAEATNGESRAGPQNGGGGDPPAAPRSIKVEAAEEPEAEPGPLAPSRTPSPPSPGPARVKAELSSPTPGSSPGPSALFLPHLPAAPPASEILAKMSELVHSRLQAGTGLGAPTGLFAGAPKGATCFECDITFNNVNNFYVHKRLYCSGRRPPDDVPPARRPKAAPAPPRVPPAPPSSEAEAPRSSPGPGAREDEAGSAATPEADADASGRGSEGSPSPGSGADEDDDPRRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAPAGTPAPSAPPVRSRRRRKLYELHAAGPAPPLAGPAPPLAGPAPPSAPGSAPTPPGPAPTPPASPRPGSGSGQEAAEGPIDLSKKPRRQAPAAAPGPAPGLAALADYHECTACRVSFHSLEAYLAHKKFSCPAAPRRLRAAPEDPPAVVCPYCPPNGVVRGDLIEHFRLAHGLLLGKPLVGPGAEARTPSPAAPRDGLNGQDLQEPPASSPRPGPPPAASPEAVPTPPSYSDKGVQTPSQGAPAPVPNGNHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK", "length": 1011, "header": "tr|G3MWI7-1|F1N6T0_BOVIN Computationally mapped isoform of Zinc finger protein ZFPM1 OS=Bos taurus OX=9913 GN=ZFPM1 PE=4 SV=3 CANONICAL=F1N6T0-1" }, "locus": { "chromosome": "18", "start_pos": 13781406, "end_pos": 13743920, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063705.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063705.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053887.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053887.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 503, "start_aa": "Thr", "end_pos": 503, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr503", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 636, "start_aa": "Thr", "end_pos": 636, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr636", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 64, "start_aa": "Thr", "end_pos": 64, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr64", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 706, "start_aa": "Thr", "end_pos": 706, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr706", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 755, "start_aa": "Thr", "end_pos": 755, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr755", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 762, "start_aa": "Thr", "end_pos": 762, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr762", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 928, "start_aa": "Thr", "end_pos": 928, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr928", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:528338", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528338", "resource": "KEGG Pathway" }, { "id": "R-BTA-8936459", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936459", "resource": "Reactome", "description": "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A168-1", "protein_name": "Zinc finger protein, multitype 1", "gene_name": "Zfpm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRRKQSNPRQIKRSLRDMEAGEEAKGMDISPMEQEATAPEAPAIEEPPSPPREDVSLPTVSAPPESPDDPEDVEGQELEMRPQDEKKEEKEEESAMASPWSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPALTLMVDESCWLRMLPQALTEEEANSEIYRKDDALWCRVTKAVPSGGLLHVLLVAEPHGTPKHPVQEPEEAGSSGPVHTDIQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQRASSPVSATEEKPKETYPNERICPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSAWPTGVCHNCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAAKLPSDSLTGFQQHSLRHSPLVPADKAPTPSSGLDSKALAEVTNGETRVPPQNGGSSESPAAPRTIKVEAAEEPEAARASGPGEPGPQAPSRTPSPHSPNPVRVKAELSSPTPGSSPGPGELTMAGTLFLPQYVFGPDAGTTTVPAAPQASEILAKMSELVHNRLQQGAGSSGVAGTPTGLFPGTKGATCFECEITFNNINNFYVHKRLYCSGRRAPEDPPAVRRPKAATGSARAPAGVAAEPDPPRSSPGPGPREEEASGATTPEAETAGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPPVPTPAPGPAAPALTAPPVRTRRRRKLYELPAAGAPPPAAGPAPVPVVSSPTAELPSSPRPASASAGPAPTPSPGPVPDGPIDLSKRPRRQTPDTPTALPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPLRTTALCPYCPPNGRVRGDLVEHLRQAHGLQVAKPAASPGAEPRTAAERAPRDSPDGRAPRSPSPAPENTPSDQADQGARTSCKGPPAPAPAPGGGGGHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK", "length": 1001 }, "evidence": [ { "id": "F1N6T0", "url": "https://omabrowser.org/oma/group/F1N6T0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35615-1", "protein_name": "Zinc finger protein ZFPM1", "gene_name": "Zfpm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRRKQSNPRQIKRSLRDMEAGEEAKAMDSSPKEQEAPDPEAPAIEEPPSPPREDVSPPAVPAPPESPEDPEDMEGQELEMRPQDEEKEEKEEEAAMASPWSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPAVTLMVDESCWLRMLPQVLTEEAANSEIYRKDDALWCRVTKVVPSGGLLYVRLVTEPHGAPRHPVQEPVEPGGLAPVHTDIQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQRAGSPVSATEEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHNCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAAKLPPDSLAGFQQHSLMHSPLVPADKAPTPSSGLDSKAEVTNGETRVPPQNGGSSESPAAPRTIKVEAAEEPEATRASGPGEPGPQAPSRTPSPHSPNPVRVKTELSSPTPGSSPGPGELTMAGTLFLPQYVFSPDAGTTTVPTAPQASEILAKMSELVHNRLQQGAGSSGAAGTPTGLFSGTKGATCFECEITFNNINNFYVHKRLYCSGRRAPEDPPTVRRPKAATGPARAPAGAAAEPDPSRSSPGPGPREEEASGTTTPEAEAAGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPPAPTTAPGPAAPALTAPPVRTRRRRKLYELPAAGAPPPAAGPAPVPVVPSPTAELPSSPRPGSASAGPAPALSPSPVPDGPIDLSKRPRRQSPDAPTALPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPLRTTALCPYCPPNGRVRGDLVEHLRQAHGLQVAKPAASPGAEPRTPAERAPRDSPDGRAPRSPSPAPENTPSDPADQGARTPSKGPPAPAPAPGGGGGHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK", "length": 995 }, "evidence": [ { "id": "F1N6T0", "url": "https://omabrowser.org/oma/group/F1N6T0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IX07-1", "protein_name": "Zinc finger protein ZFPM1", "gene_name": "ZFPM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDLQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAAATDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGLAPTPSPGLDRKALAEATNGEARAEPLAQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPASEILAKMSELVHSRLQQGAGAGAGGAQTGLFPGAPKGATCFECEITFSNVNNYYVHKRLYCSGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAPPGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPPPGALGLPAAACPYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTPSKGTPAPLPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK", "length": 1006 }, "evidence": [ { "id": "F1N6T0", "url": "https://omabrowser.org/oma/group/F1N6T0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 26, "go_terms": [ { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "regulation of myeloid cell differentiation", "id": "GO:0045637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045637", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "anatomical structure formation involved in morphogenesis", "id": "GO:0048646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048646", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "leukocyte differentiation", "id": "GO:0002521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002521", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "myeloid cell differentiation", "id": "GO:0030099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030099", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "negative regulation of multicellular organismal process", "id": "GO:0051241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051241", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "megakaryocyte differentiation", "id": "GO:0030219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030219", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "mitral valve formation", "id": "GO:0003192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003192", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "tricuspid valve formation", "id": "GO:0003195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003195", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "regulation of definitive erythrocyte differentiation", "id": "GO:0010724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010724", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "embryonic hemopoiesis", "id": "GO:0035162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035162", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "negative regulation of mast cell differentiation", "id": "GO:0060377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060377", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "cardiac muscle tissue morphogenesis", "id": "GO:0055008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055008", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "positive regulation of type II interferon production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "platelet formation", "id": "GO:0030220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030220", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "ventricular septum morphogenesis", "id": "GO:0060412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060412", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "outflow tract morphogenesis", "id": "GO:0003151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003151", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "negative regulation of interleukin-4 production", "id": "GO:0032713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032713", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "atrial septum morphogenesis", "id": "GO:0060413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060413", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" }, { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "F1N6T0", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 324, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T0" }, { "id": "PS51810", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51810" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC FOG-type", "eco_id": "ECO_0000259", "start_pos": 240, "end_pos": 273, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 64, 503, 636, 706, 755, 762, 928 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 7 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_o_linked_sites", "count": 7 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 7 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_o_linked_sites", "count": 7 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N781-1", "uniprot_ac": "F1N781", "uniprot_id": "F1N781_BOVIN", "mass": { "chemical_mass": 114055.0, "monoisotopic_mass": 114055.0 }, "refseq": { "ac": "XP_005208108", "name": "ephrin type-A receptor 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208108" }, "gene_names": [ { "name": "EPHA5", "type": "recommended", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] }, { "name": "EPHA5", "type": "synonym", "evidence": [ { "id": "XP_005208108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208108" } ] } ], "protein_names": [ { "name": "receptor protein-tyrosine kinase", "type": "recommended", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781/entry#names_and_taxonomy" } ] }, { "name": "2.7.10.1", "type": "synonym", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781/entry#names_and_taxonomy" } ] }, { "name": "ephrin type-A receptor 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208108" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPHA5", "url": "https://www.uniprot.org/uniprotkb/F1N781", "locus": { "chromosome": "6", "start_pos": 80836084, "end_pos": 81240140, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009438", "url": "https://www.ensembl.org/id/ENSBTAG00000009438" } ] } } ], "crossref": [ { "id": "F1N781", "url": "https://alphafold.ebi.ac.uk/entry/F1N781", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009438", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009438", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05066", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05066", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09546", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09546", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337226", "url": "https://www.ncbi.nlm.nih.gov/gene/100337226", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N781", "url": "https://www.orthodb.org/?gene=F1N781", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46877:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46877:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01404", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01404", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07699", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07699", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14575", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14575", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25599", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25599", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928663", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005208108", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208108", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M9N5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9N5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N781-1", "url": "https://www.uniprot.org/uniprotkb/F1N781-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGSGPRGAGRLRLPSTPASLAGCSSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDNENGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVAGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHSQSCSKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCDECGGHVRYLPQQIGLKNTSVMVVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETIPVSVAASSDQSQIPIIAVSVTVGVILLAVVIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFEEIVNMLDKLIRNPSSLKTLVNASSRVSNLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL", "length": 1031, "header": "tr|F1N781-1|F1N781_BOVIN Isoform 1 of receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EPHA5 PE=4 SV=3 CANONICAL=F1N781-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9N5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N5/entry", "sequence": { "sequence": "MRGSGPRGAGRLRLPSTPASLAGCSSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDNENGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVAGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETIPVSVAASSDQSQIPIIAVSVTVGVILLAVVIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFEEIVNMLDKLIRNPSSLKTLVNASSRVSNLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL", "length": 867, "header": "tr|A0A3Q1M9N5-1|F1N781_BOVIN Computationally mapped isoform of receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EPHA5 PE=4 SV=2 CANONICAL=F1N781-1" }, "locus": { "chromosome": "6", "start_pos": 81239941, "end_pos": 80837088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069741.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069741.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065177.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065177.2" } ] } }, { "isoform_ac": "A0A3Q1MAA9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA9/entry", "sequence": { "sequence": "MRGSGPRGAGRLRLPSTPASLAGCSSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDNENGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVAGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHSQSCSKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCDECGGHVRYLPQQIGLKNTSVMVVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETIPVSVAASSDQSQIPIIAVSVTVGVILLAVVIGFLLSGRRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFEEIVNMLDKLIRNPSSLKTLVNASSRVSNLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL", "length": 1009, "header": "tr|A0A3Q1MAA9-1|A0A3Q1MAA9_BOVIN Computationally mapped isoform of receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EPHA5 PE=4 SV=2 CANONICAL=F1N781-1" }, "locus": { "chromosome": "6", "start_pos": 81239941, "end_pos": 80837088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083978.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083978.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065469.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065469.2" } ] } }, { "isoform_ac": "A0A3Q1MB85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB85/entry", "sequence": { "sequence": "MRGSGPRGAGRLRLPSTPASLAGCSSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDNENGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVAGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHSQSCSKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTTPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETIPVSVAASSDQSQIPIIAVSVTVGVILLAVVIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFEEIVNMLDKLIRNPSSLKTLVNASSRVSNLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL", "length": 919, "header": "tr|A0A3Q1MB85-1|F1N781_BOVIN Computationally mapped isoform of receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EPHA5 PE=4 SV=2 CANONICAL=F1N781-1" }, "locus": { "chromosome": "6", "start_pos": 81239941, "end_pos": 80837088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084493.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084493.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067928.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067928.2" } ] } }, { "isoform_ac": "F1N781-1", "url": "https://www.uniprot.org/uniprotkb/F1N781/entry", "sequence": { "sequence": "MRGSGPRGAGRLRLPSTPASLAGCSSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDNENGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVAGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHSQSCSKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCDECGGHVRYLPQQIGLKNTSVMVVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETIPVSVAASSDQSQIPIIAVSVTVGVILLAVVIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFEEIVNMLDKLIRNPSSLKTLVNASSRVSNLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL", "length": 1031, "header": "tr|F1N781-1|F1N781_BOVIN Isoform 1 of receptor protein-tyrosine kinase OS=Bos taurus OX=9913 GN=EPHA5 PE=4 SV=3 CANONICAL=F1N781-1" }, "locus": { "chromosome": "6", "start_pos": 81239941, "end_pos": 80837088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039576.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039576.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039366.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039366.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 574, "start_aa": "Thr", "end_pos": 574, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr574", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2682334", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "resource": "Reactome", "description": "EPH-Ephrin signaling" }, { "id": "R-BTA-3928663", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928663", "resource": "Reactome", "description": "EPHA-mediated growth cone collapse" }, { "id": "R-BTA-3928665", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "resource": "Reactome", "description": "EPH-ephrin mediated repulsion of cells" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" }, { "name": "ephrin receptor activity", "id": "GO:0005003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005003", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" }, { "name": "transmembrane-ephrin receptor activity", "id": "GO:0005005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005005", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" }, { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1N781", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 941, "end_pos": 943, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MWN2-1", "A0AAF6DMB3-1", "E1BI01-1", "A0AAA9TQL1-1", "F1MQH2-1", "F1N781-1", "F6QXU6-1", "A0A3Q1MKW9-1", "A0A3Q1M0U5-1", "F6S1J8-1", "A5D791-1", "F1N664-1", "E1BMP9-1", "F1MS00-1", "P43481-1", "A0A3Q1LR28-1", "A0A3Q1LVP1-1", "Q06807-1", "A0AAA9TD48-1", "Q5E9X2-1", "Q05688-1", "Q17R13-1", "E1BG90-1", "Q0VBZ0-1", "F1N758-1", "A0A3Q1LTC6-1", "A0A3Q1LNU2-1", "F1N1Q0-1", "A0A3Q1MHB0-1", "A0AAA9SN20-1", "A0AAA9TMY2-1", "A0A3Q1LI98-1", "E1BJ31-1", "A0A3Q1LRR9-1", "F1MX49-1", "A0A3Q1MHG9-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "E1BNE0-1", "A0A3Q1LT44-1", "A0A3Q1MJG0-1", "F1MII5-1", "F1N0D3-1", "F1N261-1", "F1N759-1", "F1N780-1", "F1MC14-1", "F1N3R6-1", "A0ABI0P1V8-1", "A0A3Q1LUE0-1", "F1MFH7-1", "F1MNW2-1", "A0AAA9SPC9-1", "F1N381-1", "F1MS29-1", "G1K218-1", "Q4TVR5-1", "A0AAA9SXH6-1", "E1BJS9-1", "A0AAA9SBR4-1", "F1MKR1-1", "F1MN51-1", "E1BCZ6-1", "E1BEL4-1", "F1MCX4-1", "F1N6J0-1", "Q3SZJ2-1", "Q769I5-1", "Z4YHD9-1", "Q06805-1", "Q3SX21-1", "A0A3Q1MAM7-1", "E1BPB5-1", "A0A3Q1MF99-1", "A0AAA9SA57-1", "A0AAA9TAT1-1", "A0AAA9THG2-1", "F1MC23-1", "A0AAA9SVL9-1", "F1MRU0-1", "A0AAA9T042-1", "E1BKP7-1", "E1BNA8-1", "F1ML02-1", "E1BPI3-1", "A0AAA9SW95-1", "G3X680-1", "A0AAA9TRY4-1", "A0A3Q1MEZ6-1", "E1B9H4-1", "E1B6X6-1", "E1B9Q2-1", "E1BPP1-1", "F1N6H6-1", "A0ABI0NRQ5-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-BTA-3928578", "name": "EPH receptors autophosphorylate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1MII5-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928578", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928578" } ] }, { "id": "R-BTA-3928591", "name": "EPH:EFN tetramers oligomerise", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1MII5-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928591" } ] }, { "id": "R-BTA-3928597", "name": "EPH:EFN dimers tetramerise", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1MII5-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928597", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928597" } ] }, { "id": "R-BTA-3928604", "name": "SFKs phosphorylate VAV2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "F1MII5-1", "F1N261-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928604" } ] }, { "id": "R-BTA-3928607", "name": "p-EPHs bind VAV2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "F1MII5-1", "F1N261-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928607", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928607" } ] }, { "id": "R-BTA-3928646", "name": "EPHAs bind EFNAs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928646", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928646" } ] }, { "id": "R-BTA-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61585-1", "E1BJS9-1", "F1MFH7-1", "E1BJ31-1", "F1N6H6-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "F1N261-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928651" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LI98", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRR9", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] } ] }, { "uniprot_ac": "A0A3Q1LT44", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LUE0", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] } ] }, { "uniprot_ac": "A0A3Q1LVP1", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LVP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LVP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP1" } ] } ] }, { "uniprot_ac": "A0A3Q1M0U5", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1M0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U5" } ] } ] }, { "uniprot_ac": "A0A3Q1MAM7", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAM7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAM7" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MF99", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MF99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF99" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MF99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF99" } ] } ] }, { "uniprot_ac": "A0A3Q1MHB0", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] } ] }, { "uniprot_ac": "A0A3Q1MHG9", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] } ] }, { "uniprot_ac": "A0A3Q1MJG0", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] } ] }, { "uniprot_ac": "A0A3Q1MKW9", "gene_name": "ALK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] } ] }, { "uniprot_ac": "A0AAA9SA57", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] } ] }, { "uniprot_ac": "A0AAA9SBR4", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] } ] }, { "uniprot_ac": "A0AAA9SN20", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] } ] }, { "uniprot_ac": "A0AAA9SPC9", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] } ] }, { "uniprot_ac": "A0AAA9SVL9", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] } ] }, { "uniprot_ac": "A0AAA9SW95", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] } ] }, { "uniprot_ac": "A0AAA9SXH6", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9TAT1", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9THG2", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] } ] }, { "uniprot_ac": "A0AAA9TMY2", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] } ] }, { "uniprot_ac": "A0AAA9TQL1", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] } ] }, { "uniprot_ac": "A0AAA9TRY4", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] } ] }, { "uniprot_ac": "A0AAF6DMB3", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0P1V8", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] } ] }, { "uniprot_ac": "A0JNB0", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "E1B6X6", "gene_name": "BAZ1B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] } ] }, { "uniprot_ac": "E1B9H4", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BCZ6", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] } ] }, { "uniprot_ac": "E1BEL4", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] } ] }, { "uniprot_ac": "E1BER5", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BIM8", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] } ] }, { "uniprot_ac": "E1BJ31", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] } ] }, { "uniprot_ac": "E1BJS9", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] } ] }, { "uniprot_ac": "E1BKP7", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] } ] }, { "uniprot_ac": "E1BMP9", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] } ] }, { "uniprot_ac": "E1BNA8", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] } ] }, { "uniprot_ac": "E1BNE0", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "F1MC14", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] } ] }, { "uniprot_ac": "F1MC23", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] } ] }, { "uniprot_ac": "F1MCX4", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] } ] }, { "uniprot_ac": "F1MFH7", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] } ] }, { "uniprot_ac": "F1MII5", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] } ] }, { "uniprot_ac": "F1MKR1", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] } ] }, { "uniprot_ac": "F1ML02", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] } ] }, { "uniprot_ac": "F1MN51", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] } ] }, { "uniprot_ac": "F1MNW2", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] } ] }, { "uniprot_ac": "F1MQH2", "gene_name": "EPHA6", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] } ] }, { "uniprot_ac": "F1MRU0", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] } ] }, { "uniprot_ac": "F1MS00", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] } ] }, { "uniprot_ac": "F1MS29", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] } ] }, { "uniprot_ac": "F1MWN2", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] } ] }, { "uniprot_ac": "F1MX49", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] } ] }, { "uniprot_ac": "F1N0D3", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] } ] }, { "uniprot_ac": "F1N1Q0", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] } ] }, { "uniprot_ac": "F1N261", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] } ] }, { "uniprot_ac": "F1N381", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N381" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N381" } ] } ] }, { "uniprot_ac": "F1N3R6", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R6" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6H6", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] } ] }, { "uniprot_ac": "F1N6J0", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] } ] }, { "uniprot_ac": "F1N758", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] } ] }, { "uniprot_ac": "F1N759", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] } ] }, { "uniprot_ac": "F1N780", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N780" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N780" } ] } ] }, { "uniprot_ac": "F1N781", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] } ] }, { "uniprot_ac": "F6QXU6", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QXU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QXU6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6QXU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QXU6" } ] } ] }, { "uniprot_ac": "F6S1J8", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6S1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6S1J8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6S1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6S1J8" } ] } ] }, { "uniprot_ac": "G1K218", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "G1K218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K218" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G1K218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K218" } ] } ] }, { "uniprot_ac": "G3X680", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3X680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3X680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X680" } ] } ] }, { "uniprot_ac": "P43481", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "Q05688", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q05688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05688" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05688" } ] } ] }, { "uniprot_ac": "Q06805", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06805" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06805" } ] } ] }, { "uniprot_ac": "Q06807", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] } ] }, { "uniprot_ac": "Q0VBZ0", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q769I5", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q769I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q769I5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q769I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q769I5" } ] } ] }, { "uniprot_ac": "Z4YHD9", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N781-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1031, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N781-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N781" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" }, { "id": "PS51550", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51550" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Eph LBD", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 231, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 350, "end_pos": 460, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 669, "end_pos": 930, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 959, "end_pos": 1023, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.10.1", "ec_name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.10.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1" }, { "id": "2.7.10.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.10.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 574 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 429, "end_pos": 431 }, { "start_pos": 454, "end_pos": 456 }, { "start_pos": 752, "end_pos": 754 }, { "start_pos": 941, "end_pos": 943 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q4W6-1", "uniprot_ac": "F6Q4W6", "uniprot_id": "F6Q4W6_BOVIN", "mass": { "chemical_mass": 60696.0, "monoisotopic_mass": 60696.0 }, "refseq": {}, "gene_names": [ { "name": "NKD1", "type": "recommended", "evidence": [ { "id": "F6Q4W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ] } ], "protein_names": [ { "name": "Protein naked cuticle homolog", "type": "recommended", "evidence": [ { "id": "F6Q4W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cell autonomous antagonist of the canonical Wnt signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MAS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS1#function" }, { "database": "UniProtKB", "id": "RU367060", "url": "https://www.uniprot.org/uniprotkb/RU367060#function" }, { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NKD1", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6", "locus": { "chromosome": "18", "start_pos": 19032328, "end_pos": 18940337, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012295", "url": "https://www.ensembl.org/id/ENSBTAG00000012295" } ] } } ], "crossref": [ { "id": "F6Q4W6", "url": "https://alphafold.ebi.ac.uk/entry/F6Q4W6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012295", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012295", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAS1", "url": "https://www.orthodb.org/?gene=A0A3Q1MAS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22611", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22611", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22611:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22611:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q4W6-1", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRARPMGARGGAGRGGGLGARLARASVRPRQQRQERVPALPRAPLSSGAASGGGERDKARRAFRARRPGAWLRDAPSSRSPSMGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGSSGPRQLRAAGTVGRGARELVGEVFRETLSEEEEEDFRLEVALPPEKSDGLASGDEKRMEKSGEPCSGSKKQLKFEELQCDVSVEEDSRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQSKKSIVLNHPDLQSARPRAETKPAEELRSWEKKQRALLRFQGDSHLEQSGCYHHCVDENIERRNHYLDLAGIENYTSQFGPGSPSVAQKSELPPRASNPTRSRSHEPEAIHVPHRKPQGADPGSFHFLDAPFAKASEVQQRLRGGTQDGSKHFVRSPKAQGKSVGVGHVARGARSKPPGGPAVPAVAPSAHLAASPALLPTLAPLGHRKHKHRAKESQQGCRGLQAPLAVGGTVVGRDHLRELPAVVVYESQAGQAVQRHEHHHHHEHHHHYHHFYQT", "length": 554, "header": "tr|F6Q4W6-1|F6Q4W6_BOVIN Isoform 1 of Protein naked cuticle homolog OS=Bos taurus OX=9913 GN=NKD1 PE=3 SV=1 CANONICAL=F6Q4W6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS1/entry", "sequence": { "sequence": "MGKLHSKPGDSFAVSAAWARKGIEEWIGRQRCPGGSSGPRQLRAAGTVGRGARELVGEVFRETLSEEEEEDFRLEVALPPEKSDGLASGDEKRMEKSGEPCSGSKKQLKFEELQCDVSVEEDSRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQSKKSIVLNHPDLQSARPRAETKPAEELRSWEKKQRALLRFQGDSHLEQSGCYHHCVDENIERRNHYLDLAGIENYTSQFGPGSPSVAQKSELPPRASNPTRSRSHEPEAIHVPHRKPQGADPGSFHFLDAPFAKASEVQQRLRGGTQDGSKHFVRSPKAQGKSVGVGHVARGARSKPPGGPAVPAVAPSAHLAASPALLPTLAPLGHRKHKHRAKESQQGCRGLQAPLAVGGTVVGRDHLRELPAVVVYESQAGQAVQRHEHHHHHEHHHHYHHFYQT", "length": 460, "header": "tr|A0A3Q1MAS1-1|F6Q4W6_BOVIN Computationally mapped isoform of Protein naked cuticle homolog OS=Bos taurus OX=9913 GN=NKD1 PE=3 SV=1 CANONICAL=F6Q4W6-1" }, "locus": { "chromosome": "18", "start_pos": 19031633, "end_pos": 18940606, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074918.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074918.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065699.1" } ] } }, { "isoform_ac": "F6Q4W6-1", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6/entry", "sequence": { "sequence": "MRRARPMGARGGAGRGGGLGARLARASVRPRQQRQERVPALPRAPLSSGAASGGGERDKARRAFRARRPGAWLRDAPSSRSPSMGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGSSGPRQLRAAGTVGRGARELVGEVFRETLSEEEEEDFRLEVALPPEKSDGLASGDEKRMEKSGEPCSGSKKQLKFEELQCDVSVEEDSRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQSKKSIVLNHPDLQSARPRAETKPAEELRSWEKKQRALLRFQGDSHLEQSGCYHHCVDENIERRNHYLDLAGIENYTSQFGPGSPSVAQKSELPPRASNPTRSRSHEPEAIHVPHRKPQGADPGSFHFLDAPFAKASEVQQRLRGGTQDGSKHFVRSPKAQGKSVGVGHVARGARSKPPGGPAVPAVAPSAHLAASPALLPTLAPLGHRKHKHRAKESQQGCRGLQAPLAVGGTVVGRDHLRELPAVVVYESQAGQAVQRHEHHHHHEHHHHYHHFYQT", "length": 554, "header": "tr|F6Q4W6-1|F6Q4W6_BOVIN Isoform 1 of Protein naked cuticle homolog OS=Bos taurus OX=9913 GN=NKD1 PE=3 SV=1 CANONICAL=F6Q4W6-1" }, "locus": { "chromosome": "18", "start_pos": 19031633, "end_pos": 18940357, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016306.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016306.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016306.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016306.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "protein phosphatase type 2A complex", "id": "GO:0000159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000159", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "positive regulation of Wnt signaling pathway, planar cell polarity pathway", "id": "GO:2000096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000096", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "axis elongation", "id": "GO:0003401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003401", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "convergent extension", "id": "GO:0060026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060026", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" }, { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "F6Q4W6", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6Q4W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4W6" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 249, "start_aa": "Glu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 }, { "start_pos": 350, "end_pos": 352 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7X5-1", "uniprot_ac": "F1N7X5", "uniprot_id": "F1N7X5_BOVIN", "mass": { "chemical_mass": 31827.0, "monoisotopic_mass": 31827.0 }, "refseq": { "ac": "NP_001192762", "name": "aquaporin-9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192762" }, "gene_names": [ { "name": "AQP9", "type": "recommended", "evidence": [ { "id": "F1N7X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ] }, { "name": "AQP9", "type": "synonym", "evidence": [ { "id": "NP_001192762", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192762" } ] } ], "protein_names": [ { "name": "Aquaporin-3", "type": "recommended", "evidence": [ { "id": "F1N7X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7X5/entry#names_and_taxonomy" } ] }, { "name": "Aquaglyceroporin-3", "type": "synonym", "evidence": [ { "id": "F1N7X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7X5/entry#names_and_taxonomy" } ] }, { "name": "aquaporin-9", "type": "synonym", "evidence": [ { "id": "NP_001192762", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192762" } ] } ], "function": [ { "annotation": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Also participates in cell permeability to H2O2 and H2O2-mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MAV3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAV3#function" }, { "database": "UniProtKB", "id": "ARBA00049592", "url": "https://www.uniprot.org/uniprotkb/ARBA00049592#function" }, { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5#function" } ] }, { "annotation": "Research on associations between variants and haplotypes of Aquaporin 9 (AQP9) gene with growth traits in three cattle breeds.", "evidence": [ { "database": "RefSeq", "id": "NP_001192762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192762" }, { "database": "PubMed", "id": "31680615", "url": "https://glygen.org/publication/PubMed/31680615" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AQP9", "url": "https://www.uniprot.org/uniprotkb/F1N7X5", "locus": { "chromosome": "10", "start_pos": 52087959, "end_pos": 52136080, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013452", "url": "https://www.ensembl.org/id/ENSBTAG00000013452" } ] } } ], "crossref": [ { "id": "F1N7X5", "url": "https://alphafold.ebi.ac.uk/entry/F1N7X5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013452", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013452", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00333", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00333", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516762", "url": "https://www.ncbi.nlm.nih.gov/gene/516762", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516762", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516762", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MQPEMEQ", "url": "https://omabrowser.org/oma/group/MQPEMEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR43829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43829:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43829:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432030", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432030", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432047", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432047", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192762", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29667", "url": "https://www.rhea-db.org/rhea/29667", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29675", "url": "https://www.rhea-db.org/rhea/29675", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "32799", "url": "https://www.rhea-db.org/rhea/32799", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "74375", "url": "https://www.rhea-db.org/rhea/74375", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MAV3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAV3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7X5-1", "url": "https://www.uniprot.org/uniprotkb/F1N7X5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPEMEQKKKSLKQRLVLKNTLAKETLSEFLGTFIMIVLGCGSVAQAVLSRGHFGGIITINTGFSMAVAMAIYVSAGVSGGHINPAVSFALCLFGRMKWFKFPFYVGAQFLGAFAGAATLFGIYYDAFMSFAGGKLLIVGENATAHIFATYPAPYLSLVNAFAEQVVATMFLLIVIFAIFDSRNLGVPRGLEPVVIGFLIVTIASSLGMNSGCAMNPARDLSPRLFTALAGWGFEVFTAGNNFWWIPVVGPLVGAAAGGFVYFLLIEIHHPDLNPDLEAEQPEDKPEKYELNAIM", "length": 295, "header": "tr|F1N7X5-1|F1N7X5_BOVIN Isoform 1 of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP9 PE=3 SV=3 CANONICAL=F1N7X5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAV3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAV3/entry", "sequence": { "sequence": "MQPEMEQKKKSLKQRLVLKNTLAKETLSEFLGTFIMIVLGCGSVAQAVLSRGHFGGIITINTGFSMAVAMAIYVSAGVSVSPPVNWSRTHLTGFLGGSSGHINPAVSFALCLFGRMKWFKFPFYVGAQFLGAFAGAATLFGIYYDAFMSFAGGKLLIVGENATAHIFATYPAPYLSLVNAFAEQVVATMFLLIVIFAIFDSRNLGVPRGLEPVVIGFLIVTIASSLGMNSGCAMNPARDLSPRLFTALAGWGFEVFTAGNNFWWIPVVGPLVGAAAGGFVYFLLIEIHHPDLNPDLEAEQPEDKPEKYELNAIM", "length": 314, "header": "tr|A0A3Q1MAV3-1|F1N7X5_BOVIN Computationally mapped isoform of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP9 PE=3 SV=2 CANONICAL=F1N7X5-1" }, "locus": { "chromosome": "10", "start_pos": 52135881, "end_pos": 52088946, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080210.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080210.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067375.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067375.2" } ] } }, { "isoform_ac": "F1N7X5-1", "url": "https://www.uniprot.org/uniprotkb/F1N7X5/entry", "sequence": { "sequence": "MQPEMEQKKKSLKQRLVLKNTLAKETLSEFLGTFIMIVLGCGSVAQAVLSRGHFGGIITINTGFSMAVAMAIYVSAGVSGGHINPAVSFALCLFGRMKWFKFPFYVGAQFLGAFAGAATLFGIYYDAFMSFAGGKLLIVGENATAHIFATYPAPYLSLVNAFAEQVVATMFLLIVIFAIFDSRNLGVPRGLEPVVIGFLIVTIASSLGMNSGCAMNPARDLSPRLFTALAGWGFEVFTAGNNFWWIPVVGPLVGAAAGGFVYFLLIEIHHPDLNPDLEAEQPEDKPEKYELNAIM", "length": 295, "header": "tr|F1N7X5-1|F1N7X5_BOVIN Isoform 1 of Aquaporin-3 OS=Bos taurus OX=9913 GN=AQP9 PE=3 SV=3 CANONICAL=F1N7X5-1" }, "locus": { "chromosome": "10", "start_pos": 52135881, "end_pos": 52088946, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017894.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017894.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017894.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017894.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Research on associations between variants and haplotypes of Aquaporin 9 (AQP9) gene with growth traits in three cattle breeds.", "journal": "Animal biotechnology", "date": "2021-04", "authors": "Zhang Jingmin, Tan Jiaoyan, Zhang Chunlei, Wang Yanhong, Chen Xi, Lei Chuzhao, Chen Hong, Fang Xingtang", "evidence": [ { "database": "RefSeq", "id": "NP_001192762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192762" } ], "reference": [ { "type": "PubMed", "id": "31680615", "url": "https://glygen.org/publication/PubMed/31680615" } ] } ], "pathway": [ { "id": "bta:516762", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516762", "resource": "KEGG Pathway" }, { "id": "R-BTA-432030", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432030", "resource": "Reactome", "description": "Transport of glycerol from adipocytes to the liver by Aquaporins" }, { "id": "R-BTA-432047", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432047", "resource": "Reactome", "description": "Passive transport by Aquaporins" } ], "orthologs": [ { "uniprot_canonical_ac": "P56627-1", "protein_name": "Aquaporin-9", "gene_name": "Aqp9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSEKDGAKKSLMQRLALKSRIAKETLSEFLGTFIMIVLGCSSIAQAVLSRERFGGIITINIGFASAVVMALYVTFGISGGHINPAVSFAMCAFGRMEWFKFPFYVGAQFLGAFVGAATVFGIYYDGLMAFAGGKLLVVGENATAFIFATYPAPFISTPGAFVDQVVSTMFLLLIVFAMFDSRNLGVPRGLEPVVIGLLIIVLSCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFTVGNNFWWIPVVGPMIGAFLGGLIYILFIQMHHSKLDPDMKAEPSENNLEKHELSVIM", "length": 295 }, "evidence": [ { "id": "F1N7X5", "url": "https://omabrowser.org/oma/group/F1N7X5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9SAI4-1", "protein_name": "Aquaporin NIP6-1", "gene_name": "NIP6-1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDHEEIPSTPSTPATTPGTPGAPLFGGFEGKRNGHNGRYTPKSLLKSCKCFSVDNEWALEDGRLPPVTCSLPPPNVSLYRKLGAEFVGTLILIFAGTATAIVNQKTDGAETLIGCAASAGLAVMIVILSTGHISGAHLNPAVTIAFAALKHFPWKHVPVYIGAQVMASVSAAFALKAVFEPTMSGGVTVPTVGLSQAFALEFIISFNLMFVVTAVATDTRAVGELAGIAVGATVMLNILIAGPATSASMNPVRTLGPAIAANNYRAIWVYLTAPILGALIGAGTYTIVKLPEEDEAPKERRSFRR", "length": 305 }, "evidence": [ { "id": "F1N7X5", "url": "https://omabrowser.org/oma/group/F1N7X5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "detoxification of arsenic-containing substance", "id": "GO:0071722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071722", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "water transport", "id": "GO:0006833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006833", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "glycerol transmembrane transport", "id": "GO:0015793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015793", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "water channel activity", "id": "GO:0015250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015250", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "glycerol channel activity", "id": "GO:0015254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015254", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "urea channel activity", "id": "GO:0015265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015265", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "hydrogen peroxide channel activity", "id": "GO:0140070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140070", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" }, { "name": "urea transmembrane transporter activity", "id": "GO:0015204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015204", "evidence": [ { "database": "UniProtKB", "id": "F1N7X5", "url": "https://www.uniprot.org/uniprotkb/F1N7X5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29667", "name": "", "equation": "H2O(in) = H2O(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29667", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29667" } ] }, { "id": "29675", "name": "", "equation": "glycerol(in) = glycerol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29675", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29675" } ] }, { "id": "32799", "name": "", "equation": "urea(in) = urea(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "32799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32799" } ] }, { "id": "74375", "name": "", "equation": "H2O2(out) = H2O2(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "74375", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/74375" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7X5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 295, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7X5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7X5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N554-1", "uniprot_ac": "F1N554", "uniprot_id": "F1N554_BOVIN", "mass": { "chemical_mass": 68937.0, "monoisotopic_mass": 68937.0 }, "refseq": { "ac": "XP_015327817", "name": "polypeptide N-acetylgalactosaminyltransferase 10 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327817" }, "gene_names": [ { "name": "GALNT10", "type": "recommended", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ] }, { "name": "GALNT10", "type": "synonym", "evidence": [ { "id": "XP_015327817", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327817" } ] } ], "protein_names": [ { "name": "Polypeptide N-acetylgalactosaminyltransferase", "type": "recommended", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554/entry#names_and_taxonomy" } ] }, { "name": "Protein-UDP acetylgalactosaminyltransferase", "type": "synonym", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554/entry#names_and_taxonomy" } ] }, { "name": "polypeptide N-acetylgalactosaminyltransferase 10 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015327817", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327817" } ] } ], "function": [ { "annotation": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MDA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDA8#function" }, { "database": "UniProtKB", "id": "ARBA00056323", "url": "https://www.uniprot.org/uniprotkb/ARBA00056323#function" }, { "database": "UniProtKB", "id": "A0A3Q1MN21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN21#function" }, { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GALNT10", "url": "https://www.uniprot.org/uniprotkb/F1N554", "locus": { "chromosome": "7", "start_pos": 65702575, "end_pos": 65477777, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034113", "url": "https://www.ensembl.org/id/ENSBTAG00000034113" } ] } } ], "crossref": [ { "id": "F1N554", "url": "https://alphafold.ebi.ac.uk/entry/F1N554", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23476", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23476", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787200", "url": "https://www.ncbi.nlm.nih.gov/gene/787200", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDA8", "url": "https://www.orthodb.org/?gene=A0A3Q1MDA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MN21", "url": "https://www.orthodb.org/?gene=A0A3Q1MN21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N554", "url": "https://www.orthodb.org/?gene=F1N554", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11675:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11675:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02709", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02709", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015327817", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327817", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23956", "url": "https://www.rhea-db.org/rhea/23956", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52424", "url": "https://www.rhea-db.org/rhea/52424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MDA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDA8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N554-1", "url": "https://www.uniprot.org/uniprotkb/F1N554-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAAAAAAGQGSHNQPKKSFFFGDRQKLKDWHDKEAIKRDAQRVGDGEQGKPFPLTYAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCKSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASAATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAMDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEHIYQRRPEYRHLSAGDVTAQKKLRSSLNCKSFKWFMTKIAWDLPQFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLESCIRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKDQTLYHPVSGSCMDCSESDHRIFMNTCNPSSPTQQWLFEHTNSTVLEKFNSN", "length": 603, "header": "tr|F1N554-1|F1N554_BOVIN Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT10 PE=3 SV=5 CANONICAL=F1N554-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDA8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDA8/entry", "sequence": { "sequence": "MEYQWDKKGSHNQPKKSFFFGDRQKLKDWHDKEAIKRDAQRVGDGEQGKPFPLTYAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCKSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASAATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAMDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEHIYQRRPEYRHLSAGDVTAQKKLRSSLNCKSFKWFMTKIAWDLPQFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLESCIRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKDQTLYHPVSGSCMDCSESDHRIFMNTCNPSSPTQQWLFEHTNSTVLEKFNSN", "length": 558, "header": "tr|A0A3Q1MDA8-1|F1N554_BOVIN Computationally mapped isoform of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT10 PE=3 SV=2 CANONICAL=F1N554-1" }, "locus": { "chromosome": "7", "start_pos": 65700085, "end_pos": 65481381, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080776.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080776.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068387.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068387.2" } ] } }, { "isoform_ac": "A0A3Q1MN21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN21/entry", "sequence": { "sequence": "MGSHNQPKKSFFFGDRQKLKDWHDKEAIKRDAQRVGDGEQGKPFPLTYAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCKSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASAATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAMDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEHIYQRRPEYRHLSAGDVTAQKKLRSSLNCKSFKWFMTKIAWDLPQFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLESCIRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKDQTLYHPVSGSCMDCSESDHRIFMNTCNPSSPTQQWLFEHTNSTVLEKFNSN", "length": 551, "header": "tr|A0A3Q1MN21-1|F1N554_BOVIN Computationally mapped isoform of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT10 PE=3 SV=2 CANONICAL=F1N554-1" }, "locus": { "chromosome": "7", "start_pos": 65700085, "end_pos": 65506263, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067682.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067682.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070889.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070889.2" } ] } }, { "isoform_ac": "A0AAA9STZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ8/entry", "sequence": { "sequence": "MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAAAAAAGQGSHNQPKKSFFFGDRQKLKDWHDKEAIKRDAQRVGDGEQGKPFPLTYAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCKSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDFSDRDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAMDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEHIYQRRPEYRHLSAGDVTAQKKLRSSLNCKSFKWFMTKIAWDLPQFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLESCIRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKDQTLYHPVSGSCMDCSESDHRIFMNTCNPSSPTQQWLFEHTNSTVLEKFNSN", "length": 541, "header": "tr|A0AAA9STZ8-1|F1N554_BOVIN Computationally mapped isoform of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT10 PE=3 SV=1 CANONICAL=F1N554-1" }, "locus": { "chromosome": "7", "start_pos": 65700085, "end_pos": 65477976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096835.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096835.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089897.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089897.1" } ] } }, { "isoform_ac": "F1N554-1", "url": "https://www.uniprot.org/uniprotkb/F1N554/entry", "sequence": { "sequence": "MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAAAAAAGQGSHNQPKKSFFFGDRQKLKDWHDKEAIKRDAQRVGDGEQGKPFPLTYAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCKSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELIAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASAATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAMDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEHIYQRRPEYRHLSAGDVTAQKKLRSSLNCKSFKWFMTKIAWDLPQFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLESCIRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKDQTLYHPVSGSCMDCSESDHRIFMNTCNPSSPTQQWLFEHTNSTVLEKFNSN", "length": 603, "header": "tr|F1N554-1|F1N554_BOVIN Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT10 PE=3 SV=5 CANONICAL=F1N554-1" }, "locus": { "chromosome": "7", "start_pos": 65700085, "end_pos": 65477976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048360.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048360.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045411.6", "url": "https://www.ensembl.org/id/ENSBTAP00000045411.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" }, { "name": "polypeptide N-acetylgalactosaminyltransferase activity", "id": "GO:0004653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004653", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" }, { "name": "protein O-linked glycosylation via N-acetyl-galactosamine", "id": "GO:0016266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016266", "evidence": [ { "database": "UniProtKB", "id": "F1N554", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23956", "name": "", "equation": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "Q5EA41-1", "A0AAA9TS02-1", "A0AAA9S1Y7-1", "F1N554-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9S5W3-1", "E1B9U7-1", "A0AAA9T153-1", "A0A3Q1N2Q7-1", "E1BPR6-1" ], "evidence": [ { "id": "23956", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23956" } ] }, { "id": "52424", "name": "", "equation": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "Q5EA41-1", "A0AAA9TS02-1", "A0AAA9S1Y7-1", "F1N554-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9S5W3-1", "E1B9U7-1", "A0AAA9T153-1", "A0A3Q1N2Q7-1", "E1BPR6-1" ], "evidence": [ { "id": "52424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52424" } ] }, { "id": "R-BTA-913675", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-9942384" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9T153-1", "F1N554-1", "F6QA59-1", "F6RJ62-1", "A0AAA9S1Y7-1", "E1BPR6-1", "E1B9U7-1", "A0AAA9S5W3-1", "E1BKQ9-1" ], "evidence": [ { "id": "R-BTA-913675", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913675" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9942384", "participant_name": "UDP-GalNAc [Golgi lumen]", "crossref": [ { "id": "67138", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551132", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M986", "gene_name": "GALNT2", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1M986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M986" } ] } ] }, { "uniprot_ac": "A0A3Q1N2Q7", "gene_name": "GALNT12", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1N2Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2Q7" } ] } ] }, { "uniprot_ac": "A0AAA9S1Y7", "gene_name": "GALNT14", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Y7" } ] } ] }, { "uniprot_ac": "A0AAA9S5W3", "gene_name": "GALNT3", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S5W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W3" } ] } ] }, { "uniprot_ac": "A0AAA9T153", "gene_name": "GALNT7", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9T153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T153" } ] } ] }, { "uniprot_ac": "A0AAA9TS02", "gene_name": "GALNTL6", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS02" } ] } ] }, { "uniprot_ac": "E1B9U7", "gene_name": "GALNT17", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ] } ] }, { "uniprot_ac": "E1BDW8", "gene_name": "GALNT11", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BDW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDW8" } ] } ] }, { "uniprot_ac": "E1BHN6", "gene_name": "GALNT15", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BHN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHN6" } ] } ] }, { "uniprot_ac": "E1BKQ9", "gene_name": "GALNT5", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BKQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKQ9" } ] } ] }, { "uniprot_ac": "E1BPR6", "gene_name": "GALNT9", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BPR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ] } ] }, { "uniprot_ac": "F1N554", "gene_name": "GALNT10", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ] } ] }, { "uniprot_ac": "F6QA59", "gene_name": "GALNT8", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6QA59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QA59" } ] } ] }, { "uniprot_ac": "F6RJ62", "gene_name": "GALNT18", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6RJ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RJ62" } ] } ] }, { "uniprot_ac": "Q07537", "gene_name": "GALNT1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] }, { "ec_number": "2.4.1.41", "activity": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] }, { "ec_number": "2.4.1.41", "activity": "", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] } ] }, { "uniprot_ac": "Q5EA41", "gene_name": "GALNT6", "activity": [ { "ec_number": "2.4.1.41", "activity": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "Q5EA41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA41" } ] }, { "ec_number": "2.4.1.41", "activity": "", "evidence": [ { "id": "Q5EA41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA41" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554" }, { "id": "SM00458", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00458" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ricin B lectin", "eco_id": "ECO_0000259", "start_pos": 460, "end_pos": 590, "start_aa": "Trp", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00027JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00030VN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00031MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00032MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00033MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00034MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00034UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00035MO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00036MO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00037MO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00038MO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00039MO", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G00040MO", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G00041IL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00041MO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G00042MO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G00043MO", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G00044MO", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G00063MO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00069YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00079IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00094SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00112IO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00139WK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00140UB", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G00140YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00164QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00196CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00219VH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00230IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00234GG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00238CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00241VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00249XF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00257RE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00257UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00277SO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00287UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00288RP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G00318OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00321UH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00335JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00371DJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00372ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00376RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00379PJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G00383NC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00387BU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00390EC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G00394CR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00423TL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00428HK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00430ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00464AQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00467QU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00468NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00496OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00520NI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00523PT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G00542QA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00546ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00560KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00567EI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G00569WM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00598IA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00641XC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G00652BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00653TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00654GN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00660CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00675GF", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G00682IE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00707RC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00728SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00729SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00745CN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00745GK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G00754TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00769YD", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G00771KB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00789VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00802PL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G00803TF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00852XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00862ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00872ZT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00891GP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00895EF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00897BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00901NZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00907IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00924FH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00932UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00944OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00950FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00952LS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00967VH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00978GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00979XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00980BE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00987AB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G00997UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01004EH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01033BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01040ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01044ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01056RH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01097FM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01102LZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01116MS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01140NK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G01155GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01203BZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01236CM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01243KR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01282UD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01284WP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01287FH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01302LF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01316HN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01325OU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01351CD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01356MD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01357LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01362WX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01376HR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01416HI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01437WY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01445XB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01447VG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01450RG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01453BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01455VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01457KB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01464ES", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01471GI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01476LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01518MI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01520KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01528QE", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G01532FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01534TU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01546PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01567JL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01577DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01584VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01608UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01614ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01618EL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01625GQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01643LM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01657UH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01665LU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01666SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01674VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01682LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01707KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01710XJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01722HI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01725BW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01726AR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01736JN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01744JD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01747FB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01749YL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01753LJ", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G01759NM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01763RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01769GP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01784XC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01801SZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01802HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01822KD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01856DB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G01864UR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01866QN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01869FL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01877VI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01877XT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01879FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01912GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01922RI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01923FT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01999VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02020YO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02025JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02032MW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02033VO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02042KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02066SJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02070ZG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02078ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02089YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02092XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02096RK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02127XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02131QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02150AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02151GJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02161CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02180YM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02188HQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02230VA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02239FM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02244ID", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02256MB", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G02275IQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02288EO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02289NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02297WO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G02305XD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02316AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02322YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02353KU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02366EM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02370LQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02377RY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02379AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02387FV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02393LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02398MD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G02402NL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02403ZU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02404UN", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G02405SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02442MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02452RJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02460JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02471VE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G02522JF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02530VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02539TH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02550PY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02559GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02562EQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02563ZC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02581SF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02586QB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G02594WS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02595UE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02608NW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02613LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02624KW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02637UJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02642GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02651QY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02684WR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02701ML", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G02702PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02725GF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02729OV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02747VH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02752WS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02764NO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02799CL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02841PN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02844SX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02856QE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02860LZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02864GJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02873KW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G02906NO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02912JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02915JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02928DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02937FA", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G02942YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02953CZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02972HU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02985MG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G02990AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03003KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03016AA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03016BW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03018QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03024EJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03027LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03035VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03049NB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03052ZR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03061QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03127JO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03129RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03140AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03146JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03150CV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03163GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03168RN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03171HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03172PR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03197WV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03200OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03211IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03213HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03249SR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03263DS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03266UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03272YK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03278MV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03289LB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03304QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03325JN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03339IQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03340FG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03379XU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03412UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03425VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03429MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03433NI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03438WE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03462LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03466XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03468CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03468RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03470GM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03484HH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03494YC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03505EQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03513BY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03520RT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03542TR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03549GG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03549GS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03574EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03575DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03588SZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03591CN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03591EN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03603IS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03605AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03644PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03651GB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03670RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03674DU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03714XC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03720YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03753TG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03766GQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03770XP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03792OA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03796EF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03819IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03825PZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03825XC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03840OO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03847RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03852KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03877AD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G03900NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03912AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03916DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03923CH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03941EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03950FF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03968JR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G03975EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03989SP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03998SF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04002YJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04014AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04014FP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04016KC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04043RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04062VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04074KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04088QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04091CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04114CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04116CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04130SK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04137HF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04181GO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04185QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04210UW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04241UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04267RL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04267XF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04269FO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G04289KQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04298QC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04324CR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04337AE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04339EV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G04348LJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04352JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04402ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04406VW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04407AH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G04421LE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04422XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04428BJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04438UN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04450CG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04459VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04464LR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04473OG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G04478DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04483QG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04490OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04505IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04512BK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04513DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04522ZB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04527KW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04531ET", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04531NI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04534UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04536JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04540PY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04547KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04548YV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04557PM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04564SK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04608YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04631XC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04638IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04653HU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04699IC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G04712IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04734LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04737UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04760HF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G04760XP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04765GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04820ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04838ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04842IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04849OP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G04908IA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04917SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04949CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04970RV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G04984PI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05002AF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05026EL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05028TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05096XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05106AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05107KY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05128BK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G05159DR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05180BW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05183GM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05184IQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05187DJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05189AI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05191EM", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G05208JP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05220ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05231YG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05234QD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05235KE", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G05239GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05252QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05252XR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05259MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05268QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05278GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05286IK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05324AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05344UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05361BA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05367PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05367SU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05374TU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05378UG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05379WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05380VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05384EB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G05394VU", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G05397XY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05400IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05402FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05405HZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05410WY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05411CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05412ZS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G05413EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05428SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05456PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05490PJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05543BI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05562YT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05570RS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G05573WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05597SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05620JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05620VJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05633TS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05644LC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05665LK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05669ME", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05670VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05675LB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05690OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05694MA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05694XS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05724WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05767GS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05774PX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05784LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05784QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05785JJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05801MA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G05819IS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05827UQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05835TV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G05848DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05874CB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G05882RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05892LT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05918XD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G05955CJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05970FR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G05987PT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G05994BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06022CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06036CF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G06057IP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G06067PC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06087NW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06090HW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06104DC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06116KH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06149AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06161ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06162AQ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G06172PE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G06175CN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G06187MQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06225LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06230AO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06233HK", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G06240OP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06248CM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06275FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06291OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06300IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06303QR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06317RG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06339MJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G06341YK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06342XU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06366AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06404BM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06408QU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06411SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06415PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06435TQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G06439PI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06448OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06449JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06453RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06460LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06463OO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06477WS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06499NY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06503AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06507BB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06523WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06558RX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06563KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06566UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06577DG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06593KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06601IE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06624ZC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G06646VA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G06650FN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G06654RA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06661NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06662OV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06662ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06676BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06710OE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06755AP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06768ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06783AN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06786CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06810ZN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06840BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06864JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06893QX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06893ST", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G06938KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06963BI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06967GN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G06969QL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06990BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G06990MN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G07014IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07025FE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G07061BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07061YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07068RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07078LK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07082VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07099MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07099ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07100DF", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G07104FL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G07141OG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07145VL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G07164WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07166NN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G07176DR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G07191NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07210GE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G07247VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07275AV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07281UF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07285FW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07293JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07304BE", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G07304ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07360NF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G07393CN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G07395MI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G07398EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07405CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07430HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07435LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07443RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07479EG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07480TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07489IL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07527DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07532UC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07543GD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07570IW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G07578MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07610EM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07610JY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G07611FT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07620UR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G07641WS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G07646UD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G07676GT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07677VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07680WY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07689ET", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G07692KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07695IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07724XN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G07764JS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07779GP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07784RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07789RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07808ZA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G07819HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07820YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07831TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07858AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07869UA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07898UR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07904XW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07932PU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G07937GC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G07943FD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07981IJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G07982LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G07990CD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G07995UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08016YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08033FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08043FC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G08046LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08055MG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08059ZN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08083HB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G08107SW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G08115PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08116AL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08131WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08140FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08178PQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08190JB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G08201TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08201TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08224KD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08244HV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08244KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08244YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08246QI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G08264JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08265CU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08267YC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08275UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08306FC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08308ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08358DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08358SM", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G08366OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08371CD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08382XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08397LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08403NB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G08425VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08426DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08459GF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08465VN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08514IA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G08516DU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08524NC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G08566CQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08569VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08577GJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08606TA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08634HO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G08660AA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08670DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08697NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08700OQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08715FO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08728GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08735WG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08737TR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08744HU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08758GZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08772WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08784DO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08807HM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G08817RK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G08862JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08892TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08941LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08952PH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G09008LJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09053BO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09060TD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09071DK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09079WY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09108HO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09117FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09125MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09127IA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09130SS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09139MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09147XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09153LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09154YX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09163PD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09182TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09185DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09198TC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09207SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09224US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09226UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09234AI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09283JE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09287HW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09367JM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09403AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09423RD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09424UT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09425PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09441IP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G09441VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09480OP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09508VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09520ZQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G09575SG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G09577ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09583DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09588MX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09620VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09640VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09642IX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09663DE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09678FF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09682KX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G09698FP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09756YR", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G09761AD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09764PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09767ET", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G09778JK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G09781FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09782EI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09786SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09793BH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09805DP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09805UR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09812PB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09822LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09831CM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G09845DR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09859LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09892NW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G09911WJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G09921KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09938IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09941BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09947VX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09959OR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09969GE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G09980KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10013HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10023KT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10082ZS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10104VB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G10110YZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G10119AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10148CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10174LI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10177BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10180QX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10199RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10199RZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10204GU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10225UW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10247HK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10257XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10269QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10287KB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10290UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10300QZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G10302UO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G10325PN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10341DR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10343DO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G10372YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10388YZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10408DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10408ZL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G10436HD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10453CW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G10480CH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G10487BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10514PF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10515PV", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G10526QU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10552FV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10564SS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10581YA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10604KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10608NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10630CU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10643IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10651WD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10665MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10679DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10687EF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G10688VV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G10698NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10705PR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10706IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10709GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10736VG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10739QG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G10746HE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10768ZE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10787GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10816YX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10818TP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G10831FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10836AU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G10859BP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G10924UK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G10925II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10931ML", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G10939BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10954DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10954XM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G10993EM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11031EI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11039UJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G11061BV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11061VC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11078XZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11083DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11091XO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11104AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11105TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11120EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11122ZF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11143QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11160KY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G11198HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11201QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11210ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11218TW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11220GW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G11234AI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G11237JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11253PI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11253WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11254WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11259WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11260US", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G11263YZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11265MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11272SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11276SJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G11288UE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11302IV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G11340UD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11343WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11349QC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11350ZR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11366PY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11373TT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11374GO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G11377IU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11382ZM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G11411KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11427UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11457RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11466IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11466SI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G11482NO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G11589YK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11603CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11647UD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G11669SL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G11679KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11683WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11699WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11704PO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11730TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11737JS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11778HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11795BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11819NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11821VL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G11827HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11830CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11846US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11848VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11863CH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G11863HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11876US", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G11889PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11905CY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G11907PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11914JH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G11932BY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G11936KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11937GI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11940TK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G11980DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11985MT", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G12000YX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12019PJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G12020PN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G12032IY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12035CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12040RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12074QJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12075FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12080OQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12100NK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12111NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12114XT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12121CY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12122TT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12124FY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G12133SZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12150EL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12190QO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12193VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12204PG", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G12230UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12232DG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G12232OT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12233LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12339WZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12340JM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12347FB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G12347ZH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12350CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12357FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12365RQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12389NM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12396GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12405JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12428MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12429DG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G12455XO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12486YB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12493OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12493UH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12510ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12525VG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12526XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12541EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12548MD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12573LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12573WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12574EB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12604MY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12610QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12616PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12619FL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12627CA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12637ID", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12678YV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12679QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12680ES", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12696IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12697UE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12719GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12720KS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12726EP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12744WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12756LW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12761QA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12772KY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G12781XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12785ZM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G12813VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12835RP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G12847GY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G12848QL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12850TQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12891KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12893IS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12900GB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G12902SM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12944WQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12962XA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G12969QE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G13031IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13041DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13041EF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13063NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13089IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13101AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13102EV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13104VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13122AV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G13125OG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G13159TN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13168IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13179DW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G13179FD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13204HV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13205MF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13214IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13223JD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13230RR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13233BL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G13236VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13251BD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13258AZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13260JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13260WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13292XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13305DT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G13346FI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13346PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13355CI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13359QL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13442BO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G13458KB", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G13477DY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13483MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13496UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13500IP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13511YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13520PN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G13523IF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13523SK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13600HM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13609NI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13610SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13616KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13625HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13635IS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13640RX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G13666UP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G13684QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13695SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13715AS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G13717KM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G13760QV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13761UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13764NR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13764RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13767YY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13782XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13785BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13789ZE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G13791TE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G13813GW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13814UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13816ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13824WQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G13836FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13836RN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13846OY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G13858YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13863XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13872KR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13885FQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G13890JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13890RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13894RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13934YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G13968BO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G13976VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13985TC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14009XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14014EQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14023SP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14053SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14090RI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14119CE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G14125ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14130OH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G14133PN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G14138XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14188TW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14191ZT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G14195FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14205YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14227RA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14238UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14250HG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14259XA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14296RM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14302JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14303LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14316XA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14317JF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G14346JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14375KO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14379EB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14380OJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G14392HC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14442NU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14446LS", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G14453LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14513HL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14514DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14515IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14524OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14532FN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14533ZS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14555ST", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14558IN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14567YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14591XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14597KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14606ZK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G14623FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14645TH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14646AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14660IB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14676JD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14689BA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14693JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14708HL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14711SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14722QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14781HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14812IG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14815WH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14829OL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G14838MX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14840QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14845YK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G14847GM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14868UU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14870EV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G14911GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14919CV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14920PG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14931HB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14955CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14965PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14973GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14978ZY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G14997LZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15003XX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15011KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15023FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15030FS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G15031GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15033WI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15048BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15048IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15050SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15053SL", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G15073KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15086ZG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15090NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15099DI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15144TI", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G15148GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15173TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15178AV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15178NA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G15197TW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15208OO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15209ON", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G15220QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15249CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15270BO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15271GT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15307GJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15343IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15367TG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15379YZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15393WU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15442IV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15446MA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15454NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15467EU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15484AW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15509XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15555MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15563FY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G15570UM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15577GZ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G15577KP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15618NB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15626ED", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15631KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15633AT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15635CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15642UW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15648GT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15654DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15667KI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15684YZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G15690OZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G15706DW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G15714MJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G15718TL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15733CB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15756SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15772KA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15779LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15794WJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15807NZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15813JZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15819YF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15843BD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15848IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15849KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15867AH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15867XT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G15870AR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15876HU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15882EZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G15935OB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15949YP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G15952WX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G15985WB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16014UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16040DE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G16040ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16056IF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G16059HK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16078YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16079QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16111VB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16135DK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16136DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16214HG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16265YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16268BN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16270SN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16292QQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16296RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16327YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16331AD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16344NR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16345OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16365JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16370GQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16373HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16413MV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16415EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16438UK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16440EL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16456ZV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G16458JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16459CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16463NX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16470PS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16488DY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16502FJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16503YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16506MW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G16527XF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G16530WZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16536QD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G16558ON", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16560KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16568AK", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G16576OQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16598VU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16607CP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16609LV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16612QG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16617GO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16617HJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16656BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16682CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16687RY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16696HU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16699MZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G16706SR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16709FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16739XD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16756OS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16768QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16793QH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16816IR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G16827DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16831PL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16832WQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16837KL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16867VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16904OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16909IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16934VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16938RD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16943AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16964KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16970LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G16975LY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16982ND", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G16983XV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G16984QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17024OR", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G17034UD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17039UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17039ZC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17041QN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17050CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17054FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17055DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17055PP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17069VW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G17077YF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17089DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17091SL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G17096JA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17100VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17126MK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17133RP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17156PI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G17158TZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G17173XA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17218WW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17236TT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G17241OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17251XF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17269LY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17280PS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17294JY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17300DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17318DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17320JG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17326TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17331IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17331WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17343QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17346NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17350RY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17359VK", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G17361GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17388RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17401LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17405ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17454VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17456TE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17457PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17465GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17469LW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17480GI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17482JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17488LP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17497PZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G17500FP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17527HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17555JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17638JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17649JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17667YX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17673XH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17700LK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G17709UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17733ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17734NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17740TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17743FY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17752YB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17758YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17765UK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17766ES", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17766PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17766YF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G17782WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17810KS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17823PT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G17827ZK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G17833GN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17843DM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G17856AF", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G17862JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17866PG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G17908GP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17931ZZ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G17940HM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17981IH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17991JB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18057CS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18067AF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18072NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18078JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18090HL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18098OS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18117YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18120TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18123MJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18132YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18135ML", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18142CV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G18143YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18149MR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18155IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18174LR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18201QM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18214MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18220BL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18299YA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18315KI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18335TO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G18347PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18362VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18372EE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18388QV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18405WX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18407SY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18423OV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18427DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18431SG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18463FK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18472TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18516CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18519LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18559LN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G18559VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18561AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18564GN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18567LJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18572VB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18574CV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18583IP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18593SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18603OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18603ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18628GH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G18636LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18643HE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18653BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18695QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18702SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18707MU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18717LR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18734SR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18755YY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18800AB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18814OJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18815VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18833GC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18837FE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18837VD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18841NY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18853HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18855WX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G18871OL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18878GS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G18878PL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18890KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18892PE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G18904HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18909BQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G18924BG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18930SC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18932FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18946TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18950NM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18953GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18963DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18969NW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18975PJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G18980PD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G18982QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19002DQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19011KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19029ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19032WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19043KB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19075LN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G19114BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19121KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19122BQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19135OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19173OJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G19202DD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19203SG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G19212IL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19231UV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G19238ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19243BC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19251MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19283CF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19298NU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G19302IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19316VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19335EO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G19342EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19364EV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19369OY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19382GM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19393PU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G19425JC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G19454WY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19474IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19535JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19555CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19562CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19596BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19617WB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G19618VN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19647KE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G19656TZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G19664QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19722GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19749DC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G19752OX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19756XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19793PI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19793TF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19806ZW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19807BK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G19807JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19813SH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19832RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19910JZ", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G19913KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G19933AN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G19934JL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G19954YX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G19957ZD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20016GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20038KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20043VW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20059NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20061RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20064ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20151DP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20164HH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20165PS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20169US", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G20176YB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G20210OT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20222KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20242KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20244DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20246IY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G20251UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20254HG", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G20264TJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20269BE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20278CQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20308RQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G20310DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20359JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20362YW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20371UX", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G20372QO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20386DV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20392AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20398NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20435PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20438JB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G20440GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20453WS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20482JP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20516BM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20523OQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20528MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20538OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20557GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20557NB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G20566UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20574XF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G20575PK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20658IM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20672RS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20697RD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20709RI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20713UI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20718YD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20731UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20735IM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20739VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20745AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20752RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20826OM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20828MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20835CN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G20854YP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20857JS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G20860NB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20867OR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20873CU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20878US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20879UO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G20884GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20884IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G20887HP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20890FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20924FZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G20928FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20955DU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20966PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20967CU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G20988ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20993TP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21016US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21029LJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21030ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21077LY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21089WK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21100PW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G21108AJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G21130YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21147BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21200QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21202EE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21213KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21217SF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21227CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21246WW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G21269QM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21287OF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G21294PY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G21297DP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21312EA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G21320TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21324NP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G21360BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21373SZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21384RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21385AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21412CQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21426LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21438WG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G21468AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21472XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21498YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21506SF", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G21507RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21516LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21534CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21535UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21557NG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21564HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21573GX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21581BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21586NB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21635DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21654MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21672LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21675EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21678AK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21679QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21696DT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21699NQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G21702CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21728DQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21740EF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21755QG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21780GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21807KQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21808OQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G21827YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21845NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21852WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21859TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21877OB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21880FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21884JK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21895BD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21900DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21905ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21922VA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21928TI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G21931BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G21939VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21939WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21981BW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G21989SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G21998NE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G22012EW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G22058OT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G22070LE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G22074CA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22104MB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22134AH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22142BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22166AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22171KQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G22174MI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G22185MF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G22191PL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22219ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22222BH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22233KL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G22260HK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G22261TH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22302YD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22308XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22316RA", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G22327AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22343QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22348XO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22366MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22385OT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22411LD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22412KQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22420ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22447YO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22469CF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22473CK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22487KJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22491WZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22498IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22516UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22525ER", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22529GT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22535AU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22536LR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G22536RS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22540KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22555FB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22564NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22587IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22594FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22609VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22611UR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22626SX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22629JM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G22668GN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22682SO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22701RO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G22733YM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22745SA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22751CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22773YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22782LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22787WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22793FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22803YZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G22815DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22827ZB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G22841DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22843ZN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G22849VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22852AR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22852XR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G22903MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22912HN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G22926UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22970UG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22976NF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G22986SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22988HQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G22995SW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G23006CO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23016AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23021IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23021NE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G23032DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23048PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23056FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23061NF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23066SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23068ZB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23081CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23082UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23113ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23119MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23121SR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23126IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23152JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23152RS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23193CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23202WP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23229LN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G23236BR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G23243LM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G23250OE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G23252EB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23262BU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23262LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23263FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23280NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23285KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23314QX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23334BB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23348CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23349FM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G23351CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23355WV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23368XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23375IV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23392LW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23404PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23416ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23419VW", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G23425OX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23438NR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23442ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23447MZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23463KX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23466CZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23490ZP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G23491CM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23494UZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23501RV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23502AY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23532MP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23532XZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G23560WQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G23564VW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G23573FE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G23580VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23581EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23624JT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G23633EE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23649LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23652VU", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G23654OQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23665FB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23674BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23761KD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23801QI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23828KW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G23854HB", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G23855LE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23866EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23870PO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23888EZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23893ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23909XW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23939XO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G23975EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23979XZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G23990GP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G23996QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23999MD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24021AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24030QV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24048XD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24054AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24055UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24067PC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24080TH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24096JA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G24108KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24114NP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24115PD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G24120OI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24120VK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24123DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24137GH", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G24142JB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24146VR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24151NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24156WO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24168XN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G24169HD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24186OV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24204KW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24218RK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24218XI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G24233PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24256XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24275MB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24283IO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24293BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24296ZA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24296ZX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24303LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24312RF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24315QB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G24323NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24326HG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24327KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24363HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24366RG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24371IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24371QT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24375OF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G24387TQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24399RI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G24407ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24421WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24430RJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24434ZO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24443AK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24475OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24495XJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24497GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24508MA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24515SH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24516WB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24524DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24525ZJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24547WU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24548HS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24553WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24568RE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24569EC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24629LF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24646NC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24646WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24649MY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24650WZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24684JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24713JA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24720OO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24739SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24756UB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24768CX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24790YU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24794ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24798BT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24820LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24830XZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G24845EE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G24856YP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24859RN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24862OS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24882EK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24898NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24912KZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G24916OP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24931MM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24941BY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G24946XU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G24951IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G24970IL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G24992BU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25006JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25012OX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G25023LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25024JR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25025GX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25032EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25032PK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G25040JY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25043OJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25044JE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25061TS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25064SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25065CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25111WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25127JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25133LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25146DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25152WV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25153GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25157GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25213RP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25218ZC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25233TU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25244IK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25273PY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25299GA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25322NY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25323VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25338OL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25340RJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25351JT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25353NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25369DU", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G25369QF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25380IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25382JX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25382RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25387FN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25413GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25416CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25417NG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25421NH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25426PD", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G25436EB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25439DD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25443TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25446AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25459WN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25489WW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25498HI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25499LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25524RD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25529RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25538MM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25541GW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25559NI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25571LJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25599RT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25612EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25626YS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25650TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25694MT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25705WX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25709GM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25716MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25726HS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25733QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25738BH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25757VH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25757VY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25764DO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25766ID", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25776XU", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G25778VW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25780HH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25795DA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25804XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25812XU", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G25830YW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25835YC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25844GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25845BH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25848FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25865TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25869EQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25870FA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G25895SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25934VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25935VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25937FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25953KD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G25955UH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G25967GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25977RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25985EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26020AK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G26021BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26030RR", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G26035PF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26054ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26091TF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26099QT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26121MN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26176JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26185YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26209TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26224UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26228QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26229QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26241YH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26250DB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G26289WH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G26301NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26325AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26326PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26332EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26341AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26341TZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26358SO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G26387NM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G26392IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26427QF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26429CZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26438GB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26441FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26450SH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G26452XA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G26472EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26474AZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26493RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26497EU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26519FA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G26534SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26570RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26575AQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26592TP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26596ON", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26629OM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G26642RP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26651YZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26667EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26688CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26690QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26700PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26702BZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26712CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26718PT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G26724PP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26725PG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26725WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26754XS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26777KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26778RK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26793BW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26805JF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26806EA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26816AP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26827ST", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26833PD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26854HB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G26885DO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G26889NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26913JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26918XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26930UQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G26943DV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26981KT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G26985QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G26989YB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27000YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27025MB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G27030ZC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27063LN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G27071PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27092AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27124TL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27126VE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27167IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27192WV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27209GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27210II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27236KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27248RA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27253PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27263EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27297CO", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G27300OX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G27304BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27304YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27326AW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27345TX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27366LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27384IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27400ON", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G27409LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27428XM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G27431EQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G27439WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27440CC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27447FZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27457VN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G27469DP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G27499KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27513XS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27520PV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27523II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27526NG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27526RV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27562JG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27562KD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G27575YP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27602SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27603XJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27605DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27624KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27626TX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27642RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27655DO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27669KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27721RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27724VO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27726WH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G27730BR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27796IG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27817KG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G27854NJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G27854QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27863LS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27864IF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27866VO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27868TR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G27883TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27888XB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27889FI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G27890BG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27893KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27911BB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G27920WV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G27930EM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G27966RX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G27967WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28010TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28023AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28040SC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28077AI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28083XW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28085OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28116PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28132XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28134WJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28136FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28163VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28175OY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28198FM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G28200CZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28200IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28218FO", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G28218FT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28225EV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28226YW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28302VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28316UU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28326EU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28329XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28336JR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G28336ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28337WM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28367EQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28371PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28378DY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28378XH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28384MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28406IL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28430RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28439XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28465GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28481VT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28505XN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G28525CY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28546UC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28561QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28570DO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28582VX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28589RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28598IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28599FB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G28616IZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28628LQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28640UD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G28649NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28665FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28691NY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28694FA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28725VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28731PH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28743EB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28745PN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G28749YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28750LN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28754WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28755KN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28756KZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G28757BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28765YW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28782ND", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28791JD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28801XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28806OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28856KD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28867TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28873AQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28877HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28878FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28881KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28885XK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G28886HO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G28890YF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G28895HZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G28898NZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G28915JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28960YA", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G28975MI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G28989XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29014XV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29025YS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G29031ZI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29046MX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29081QO", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G29097OR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G29098XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29112PJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G29144HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29166US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29181KK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29214BB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29231AT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29237TW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29260RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29276PB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29290QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29301RL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G29323AG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29326OK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29348FH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29386CS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29388XG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29393FW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29394YZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29404FC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29415QN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29418HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29432PD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G29434SO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29460QV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G29470VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29477YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29489PN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29495CE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29503CE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G29524AT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G29539ZA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29546CR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29549OQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29578WS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29587NV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29622NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29624ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29628MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29636OK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G29644TC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29667VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29712MR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G29725MK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29729DB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G29739GM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G29740WT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29774PP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G29815AP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29818FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29849JL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G29853JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29860KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29867AK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29879FQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29908ZA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29914BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29914GR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G29921YQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G29929KQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29940LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29956GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29970QU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G29971IY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G29988CY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G29988NK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G30011VO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30086CM", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G30087HU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G30089VH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30090IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30110UW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30119VI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30120XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30147IW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30182VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30211JD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30214PS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G30232EU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30235YK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30241UB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30255XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30260NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30284BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30285AP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30296PK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30304DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30304IT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G30356CR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G30356XK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30365BX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30367FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30367NE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30372CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30372RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30391YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30392XP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30399ZO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30425ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30431XW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30434OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30434QC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30443NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30464XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30524AR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30524IG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G30567BL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30584YH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30586VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30590EC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30591GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30609WQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30614QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30621FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30623NS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30640LU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30647NK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30651QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30656BO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30657WR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30673NA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30697FM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G30710NE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30736BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30739AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30743FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30753DF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30774VI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G30774XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30783DZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G30832XJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30835JV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30853JB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G30871VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30872GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30897RJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G30908XZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G30926OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30933VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G30976UY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31008GE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G31061SB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31073HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31087MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31101EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31118TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31155FD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31161GA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31162WU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G31194II", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G31208LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31218QF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31234AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31248ZH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G31254YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31259RV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G31282SD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31288FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31317BJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G31317XB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31335UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31345CV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31372TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31378RD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31422IN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31457ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31489QJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G31493NN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31540HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31552VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31563MH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31565JD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G31572EB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G31586XE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31601FB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31613VR", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G31654CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31671UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31672UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31676DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31686QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31721SH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31729QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31732RG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31745GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31767KB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G31776ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31835NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31846AZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31849TV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31858VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31881UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31884XL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31894FR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G31909BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31910FR", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G31911LU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G31941YJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31948FR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31966IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31975LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G31982GY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G31997DH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G32005GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32021YB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32026LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32027JZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G32053XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32057WN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32063IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32077KC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G32104HQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G32107QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32112SX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32160JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32167RW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G32216IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32218WF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32222SO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32253LY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G32289FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32306OG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G32306SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32314DS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32319LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32333NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32361GT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G32367NO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32371YQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G32383ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32397EL", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G32405GG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32417DU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32418EP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32426JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32446BD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32460TA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32485KG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32510SF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32530PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32541GR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G32546KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32546UR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G32554UC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32556JI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G32588AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32590UP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32604OZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32625IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32652KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32660EU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32660GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32675WL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32684NS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32698TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32720EK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G32722PR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G32723SL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32735YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32748CU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32785BQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G32818XV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32826HK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32830IJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32853SP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32863IR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32877EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32885BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32908YA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32910OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32944VN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G32948PW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32953MP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G32968SR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G32989SG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G32998WQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33012HL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33018IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33024FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33044HF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33064PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33068BF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33079AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33094KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33101CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33115WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33135OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33149BM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G33159AG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33195EC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G33236UO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33278DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33286MK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33287EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33287GK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G33294DV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33318DG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33334QS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33337PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33345BX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33350QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33350UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33364OS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33368AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33377US", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33394ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33401IN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33403VX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33418YX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33433YV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G33443TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33463NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33469TY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G33479HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33508VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33569OU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33593EQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33610ZO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33627YQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G33630GM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G33633KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33637CY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33652MJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33658KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33669VL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33696UB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33711LE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33718UW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33719VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33740YL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33746QF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G33758XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33772BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33825CM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33840DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33841YH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G33858ZT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33860PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33866SM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G33877TL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G33886DT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33892UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33899KJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G33908QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33911NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33961NR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G33963JX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G33964KE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G34041VO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34049BA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34068FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34073UX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34096TA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34100DU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34115KM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G34118NA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G34123VN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34143CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34151GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34154HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34162ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34163NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34168KI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34180FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34208UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34219XL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34229EO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34256VM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34258QU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34263TP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34293SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34298UZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34311QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34336BJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G34339XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34372NB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34384TY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34398FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34449IE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34461YU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G34466UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34479QF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34487MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34539VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34592BE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G34596BP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G34602IJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34609SH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34624WH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G34632KL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34641KA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34705QH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34706DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34721BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34740CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34751ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34764BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34774HI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G34789KG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34797CS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34801BK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34807KI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G34814JC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34824ZD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34854XJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34863TS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G34865TP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34877SN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34879YH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G34891MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34893KL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G34918NO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34938CC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G34962LY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34962OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34985TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G34988TR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35033MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35037PU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35039IM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35040PZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35064LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35106OM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G35110VT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35116PX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35124IV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35127KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35127VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35129PK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35179MW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G35186LB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35199BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35212EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35214MM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35225VE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35234CM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35238UK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35241BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35243PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35252ME", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35252UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35255WG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35301YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35312VR", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35316IV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35319OJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35326EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35338HV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35343OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35347WX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G35369GY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35373KW", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G35409EZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35409SK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35419IZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35432EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35432MX", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G35437KG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35438RA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G35451HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35481RN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G35486FC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35528EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35539BB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35551AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35580MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35583GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35609TJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G35617MS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35632SP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35644NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35656YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35679QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35684CI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35689CT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G35701MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35708SF", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35718GY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35745YL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35749JN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35750SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35761ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35778AN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35799DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35804ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35805TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35815ZB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35825BV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35842UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35855PE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G35866KN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35875IX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35884UD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35886GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35891AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35896AC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35898DT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35900GR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35910XN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G35916JD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35932XK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G35941VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35945JK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G35946GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35947YD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G35949CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35955MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35977FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36008WY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36038OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36039YA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36046VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36047BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36094GH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36112QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36123IU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36124QZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36134SL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36138ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36157LL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36169RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36171FU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36175JD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36184OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36185XU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36191EH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36226TU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36231CI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36240AB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36253YP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36258NK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36288QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36341SC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G36359GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36381SH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36382RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36404TW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36406GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36410KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36410YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36416LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36443XA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36460HY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36460YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36479RD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36480VP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36482YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36494BB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36498HE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36502OW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36511AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36534NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36573BV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36588NK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36597IG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36632JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36669SS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36672CQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36674QY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36682FJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36721CL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36761DZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36765BN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36774NW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36777IJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36786TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36793ZF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36807NH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36813TJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36835IG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36839GD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36855EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36856ZX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G36878RU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G36935SP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36956RR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G36958OJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36970ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G36983SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37003XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37004VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37021DD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G37043BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37077FO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G37093SO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37097TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37115PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37134CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37134TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37137WW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37163SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37175JP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G37185HI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G37190OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37193ED", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G37203ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37222EI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37223NW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G37231JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37239FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37241GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37282LW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37283DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37297IE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37325HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37353HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37354FL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37356AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37369MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37381UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37382BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37416IO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G37416IR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37435GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37510PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37528JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37530LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37584UP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G37589WD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37597VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37619KE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G37638KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37649DI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37653KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37663EI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G37689ZA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G37716XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37717BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37723AL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G37732RA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37748PE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G37779JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37801HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37843CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37844TL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37854OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37861OJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37877OJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G37885HZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37891WT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G37927WZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G37983HD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G37983TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G37987JW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38002BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38004LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38027UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38065TJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38075PP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38078TR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38079LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38100PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38120GJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G38152SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38177ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38189CI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G38195IZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G38207GT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38215XX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G38229RW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38234JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38245IP", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G38279WF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38296RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38301SX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G38309TB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G38312ZB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38315QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38316MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38322NO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38332TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38335CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38351JR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G38351MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38361SH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38402DW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G38418FR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G38421BP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G38437KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38450KX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38451WG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38452NY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38462TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38465NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38466KL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G38468XG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38478IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38483QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38506CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38542FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38542SD", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G38568EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38581WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38584AL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38588AL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38603QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38616ID", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G38644TH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38648NC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38648SD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G38655XV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38684VZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G38688TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38691VX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38702PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38722VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38754AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38767OS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G38773BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38783ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38785NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38795WJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38799GI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38802WX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G38812YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38823IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38859XU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G38861VL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38877IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38880ZX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G38887OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38887TM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38933BS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G38933FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38960NX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G38975ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G38979WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39011RO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G39011WZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39037TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39053QM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39098FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39100MY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G39113GN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39115ZT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39120NF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39130DL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G39135DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39136MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39147LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39155BY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39162CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39174FJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G39189IR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G39192YG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39205FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39218TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39246KD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39247UK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G39258JD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39260NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39279TA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G39283IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39305NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39308RS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39321UZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39326PP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39335JJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39335NM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39369QQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39370BY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39393JJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39403FE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G39407UA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39417RW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G39422JF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39423SD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39428SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39490MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39496AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39516UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39520FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39523KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39535TC", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G39541XZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39558MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39567YM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39611QP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39615UL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39624YQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39632AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39643KO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39650IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39660LT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39676NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39713SV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39720OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39738WL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G39742GX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G39753BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39759RL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39762RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39785OI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39802SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39815IU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G39838HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39865FQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39882MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39890DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39893XZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G39916NT", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G39924QQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39927BK", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G39929JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39948NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G39952OA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G39976AK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40019JN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G40026ZO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40047QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40061GI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40069TO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40088CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40107NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40119MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40159OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40185ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40188OO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40193LX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40228ND", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40269CS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40270LS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40276YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40289VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40291QP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40294ED", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40319SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40331VO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40338WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40347YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40381AZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40393FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40394CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40397HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40413JC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40445LE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40455IF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40463SB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40468XE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40539YV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40560AU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40560HO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40560KZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40565CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40573EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40580KO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40583AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40589UV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40592RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40599KA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40606LI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40609PW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G40610OP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40626GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40652SR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40660XA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40676QN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40681EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40689UV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40706KD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40709XS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40714SE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40724HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40737YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40748QJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G40750ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40757HO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40762DZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40765JD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40778MP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G40778XV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40792HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40799GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40813RE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40825DC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40834NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40838GB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G40841KI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40852TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40871OK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40885WH", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G40907PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40909HG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G40930TX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G40957MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40963HH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40976PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40979HK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40995JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41008BQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G41021NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41037IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41063BN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G41068YK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G41079HW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G41095YZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41165OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41165PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41168HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41196CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41203GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41205RC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G41220ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41227XH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G41227ZE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G41232YR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G41245OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41247ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41255BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41257VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41286JH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41321IO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41322DV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41324RH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41330YY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41332SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41358UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41372SJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G41378OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41380ZD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G41384PQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41387TK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41403QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41424HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41429NP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41430WQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G41434QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41444DX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41445CB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G41451JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41498BE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41539MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41540NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41541BW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G41545LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41552DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41552FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41570ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41575BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41581KJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41606JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41662PV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41666CG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G41732ZR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41780OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41797KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41816PJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41834QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41835FB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41836YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41866GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41896LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G41919TD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41925MG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G41928NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41943FT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41964LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41991IF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42002WQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42008DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42028WD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42039AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42051BB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G42062OV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42065BH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42089IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42094MI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42105TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42114VS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42115GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42120JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42138LH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G42147XQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42154JB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42197WD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42206TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42233WE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G42239FO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42239OO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42245KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42256QJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42263HE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G42283HC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42295OK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42300CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42325VD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42332XP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42366QH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42368XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42373AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42388XF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42393CS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42398CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42404DZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42407QV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G42420CF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42426KZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42434UV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42444RF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42448AG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42448YD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42468DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42473FG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42475DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42519AN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G42531AE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G42537PG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42545LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42603IF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42603RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42611JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42622BJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42632OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42650PV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42658PX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42658SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42665KV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42667BL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42668PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42669SS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42714XD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42750RV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42752PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42762AJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G42772WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42791PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42797SX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42806LZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42806RX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42814RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42818YG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G42828SU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42829MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42829WM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42832EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42883ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42889MJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G42908EG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G42912TT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42927HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42929BO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G42958BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42993UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43001RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43025II", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43027VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43039PK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43059DJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G43059PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43079BH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43123WA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43133YJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43145UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43146HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43167FQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G43187MV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43204BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43211ZC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G43220WQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43221GX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G43232UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43247AT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G43265YA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G43297AH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G43315LE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43321OQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43326BY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43415UJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G43417CQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43426MU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G43438SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43438TM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43449ON", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43453MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43455UG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G43482PE", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G43484TW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43506AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43514NA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43558QZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G43572AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43585PF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G43592AC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43592PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43593XZ", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G43619YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43629KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43636EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43639BV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43656YN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43662XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43668RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43699PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43699RJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G43728SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43744JB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G43744LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43766HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43808WE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G43825VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G43828ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43840GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43875XT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G43925AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43933MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43946PN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G43972TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43980GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43993DD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44037MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44058FL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44088BX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G44094CZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44127LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44131LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44139DZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44139ZU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44144AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44159MM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44177HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44194HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44198VS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44199IU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44204WT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G44212UE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44233ST", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44236OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44244JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44254HO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G44302QI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G44342ZF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44374JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44397RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44407SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44409MI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44411RJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44414IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44419OK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G44463UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44495BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44502UE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G44504WW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44507OO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44516PQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44543KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44551BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44579CT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G44597NW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44639QZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44642MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44686VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44692LQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G44711FK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44742BQ", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G44772RK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44809JX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G44817MT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44827DP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G44828HC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G44831CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44848OP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44880NI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G44886WZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44890AJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G44900DK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G44907FO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44917UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44948DV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44980KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45002XX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45003LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45007TW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G45047PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45086UC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45089UO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45095CF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45111VK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45118AI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45120SG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45129XM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45145KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45157JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45219EG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45235OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45242NO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45289MV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45291XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45304AE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45304XA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45313PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45320WQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G45331AO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45333LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45333UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45335XP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45362KT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45367LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45388GV", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G45388VA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45402WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45403OQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G45426EB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45431CR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G45465HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45471LL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45494FB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45516HW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45516VR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45518GL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G45548XA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45563MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45563VS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45565NV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45577BZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45579IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45583YB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45592JO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45592PF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45596OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45604PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45637XA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45677CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45685UE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45690OD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45699QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45705HF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45707SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45709SU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45718WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45723ON", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45752UQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45756EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45763XX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45767XH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45819SH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G45827ZM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45828OZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45837PC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G45849QU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G45859FD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G45892JC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G45911EQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45917UD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G45939NL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G45941OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46014PJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G46015GT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46016EN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G46026IB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G46029TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46039GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46043RA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46053AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46060BG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G46088YW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G46108TZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46135RN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G46144MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46168RR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46174KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46183VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46187ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46206TA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G46222DM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46241WB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46252BF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46295MJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46304CE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46305ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46309DU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46320BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46340EI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46341RW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46360PG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G46366OF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G46382BV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46420ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46439VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46462MG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46500XL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46501AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46503UI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G46520QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46525FF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G46532VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46609ZR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46622AK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46627WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46643OR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46681XX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46686VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46711IU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G46711XU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46743AZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G46748BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46754UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46758LT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46760LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46772BG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G46785SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46790QW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46817ET", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46822ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46823CW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G46866BD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G46868TY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46887YC", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G46890BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46915JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46917EP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46926OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46935AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46960TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46974QL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G46979RJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G46996ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47058RI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G47064OG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47116HX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G47152AG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47159JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47174QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47179FY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G47180UC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47190LU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47191GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47201SK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G47262KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47307MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47318KU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G47320HQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47325XO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47330ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47331LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47345EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47357GP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G47357TH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47359DC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47360UL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G47370LX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47391NN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47393ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47439SP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G47451TR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47452EQ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G47459CP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47466SD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47483HJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47486YB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47489ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47519RD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47520QY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G47522FK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47537XW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47538PA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47541JN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47549XD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47552PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47557KS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G47560LW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47573PO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47589JT", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G47590GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47595SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47652ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47669CK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47689UY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47690ND", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47701VN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G47709SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47772RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47818EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47847UW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47867DI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47868BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47902AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47902TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47904CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47921ZO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G47925PB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G47935HW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47947JW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G47952MI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G47967NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47975LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G47999PB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48010LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48056PC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G48064BJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G48081MJ", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G48082DW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G48087XR", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G48088DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48089FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48089QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48092WH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G48115DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48126ES", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G48129FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48192XR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G48205UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48208OJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48235SJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48251XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48256FI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48265KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48265YT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48315PB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48321FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48330EV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G48355MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48365EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48367IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48367ZH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48375OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48440GN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G48465YI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G48472LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48474NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48488SV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G48499NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48503ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48525ST", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48533PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48555NH", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G48558NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48585WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48615MM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G48638TB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G48676QC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48678VC", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G48714QU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48728KD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48758KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48759RG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48768LT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48768RT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48785BB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48789OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48791KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48809BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48809VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48818KL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48822HK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48823WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48840GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48850WY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48851YP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G48854JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48884SG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G48887AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48905NO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48916GD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48938DX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G48941WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48949LD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48949QP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G48972NU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G48980VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49007JT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49015YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49029NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49045KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49077EU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49088AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49104WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49120XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49128NT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49194KA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49197SK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49200LA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49200MO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G49221CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49228QV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G49233FW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49277CJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49292FH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G49302PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49313FU", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G49322HB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G49327HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49332RT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49349BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49370IN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49390AT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49394FL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49398PG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49416SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49418IP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49426SU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49437KN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49452BL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49460YF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G49464XD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G49465QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49473DH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G49485GD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49489TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49499OL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49499SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49502SC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49508KM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G49520ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49527BY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49529DV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49542DJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49555AQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49567XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49575MY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49582PC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49584VF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G49603LL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49604IR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49609ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49622ZO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G49632WD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G49642CM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49668VU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G49671FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49685NJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G49721KD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49740JK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49741NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49742PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49743FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49747JY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G49757FF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G49763BM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G49773DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49794AK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G49844LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49854OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49915EH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49936EV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G49936GP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49944DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50001GD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50001WA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G50003EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50003FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50010ZG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G50043OB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G50068TE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G50071OA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50076EU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50077VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50117DJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50136MD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50165MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50178BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50183RQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G50192TG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G50198YU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G50215WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50223FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50241DS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G50252SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50254UQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50303VE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50339FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50355CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50362JF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50370PE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G50390GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50425IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50432RB", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G50471DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50482KM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G50501KF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50513EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50537DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50558NC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G50562TV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G50570JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50570OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50574FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50587UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50598PQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G50613GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50615HW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50617EZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50619VO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G50631BD", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G50652EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50683ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50685MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50690RS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50692JY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G50705JT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G50708YO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G50709IS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50755IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50762OP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50769VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50802FP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G50805QB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50808YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50809LR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50824HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50844LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50849OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50849VH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50896EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50903CR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G50905UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50931GW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50937OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50970GU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50977JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G50999TP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51005JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51015NS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G51018LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51020FB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51057EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51071LC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51071WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51080VE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G51091HB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51099WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51100CM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51103QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51114IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51116JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51127XF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51131QP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51140AE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G51157XM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51162XR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G51176VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51184PT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G51192NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51216AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51234MH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51247FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51316WJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51318YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51340HW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51343UJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G51349BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51357YX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51376IN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51394GL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51445EM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51472NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51473GI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51500KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51502JK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51509AZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51554PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51557QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51566FN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51586EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51588OR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G51633YN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51636DE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51665JN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G51678TA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51707UA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51709UX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51713OS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51722JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51726CK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51747SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51751TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51774AT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51809HE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51809TM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51840MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51842SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51862BI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G51877RK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G51879PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51881PG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51883EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51891WI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51911LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51911XK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G51914CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51914HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51931HC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G51947OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51957KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51963NX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G51984GX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G51992CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51993UG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G51994JG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52030AX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52051HO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G52070NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52071EY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G52106VD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52120GQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52120NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52132CU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G52138BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52144RR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52154FO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52173KV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52179YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52188XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52217QW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52227EX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52232VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52236QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52236XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52239LM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G52244NI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52262VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52273YQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52308HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52311ZH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52316LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52318OF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52361CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52376IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52380IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52380RJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G52447UD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52457VS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52460PC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52471BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52488RZ", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G52512BG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52515QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52558KX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52578IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52604VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52608IK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52608KW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52629RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52631BA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G52639VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52652AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52674BA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52706RS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52732EM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52738OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52759XA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52764DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52794ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52814NP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52839BU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52887ZR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G52902AR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G52916PO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52919XH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52937XP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G52953EP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G52960IE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G52971BE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G52971SZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52972TJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53000BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53016WG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53023PP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53031QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53034PL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53063UV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53064IK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53066XA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53084MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53084TQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53085VE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53151WW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53176VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53180NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53188WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53206FD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53208AY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53219BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53220ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53225BR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53246IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53251NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53266MQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53297ZN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53303ZX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53319DU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53330OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53362BF", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G53368RM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53385YP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53396TS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53404LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53407VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53421UG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G53426PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53435KM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53440PM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53472RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53490OS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53497KU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53498KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53502ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53510YN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53520QY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G53522BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53527TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53529RC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53535QW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53542OI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53549QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53557CQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G53568QG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53639VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53665QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53682MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53707KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53722CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53726DG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53733IF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53737KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53749RD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53778MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53809VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53810EV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53822JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53827VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53834TX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G53836TU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G53846NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53856PB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53861OY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53864RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53869ZZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53878DC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53880XP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G53909CK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G53917YN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53922OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53931RD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53933PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53944BV", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G53960NM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53979EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54029EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54043EU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54047WG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54060QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54082VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54083SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54094BQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54095CK", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G54095RB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54121EO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54125VH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54134KW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54159GO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54163UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54165VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54190AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54199ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54212AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54228HN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54250UE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54264AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54273JA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54286RT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54305YK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54316BP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54334WY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54335XN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54351IR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54362RR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54370PI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54371SF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54392HP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54394ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54402EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54409FD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54410JV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54425VX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54426UX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54434IR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54439SD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54451EW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54458VQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54461SS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54462MO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54496CV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54499HR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54500KX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54513GY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54536OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54542VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54555CN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54557YU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54561II", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G54567NU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54572EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54578OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54580AN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54624RV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54643MT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54650UF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54651DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54706BB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54727BI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54741SP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54745KD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G54760IB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54768QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54795GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54802EG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54831HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54847BG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54847JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G54860YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54870QZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G54887WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54890PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54896JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54925RP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54938LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54945BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54951YG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54951ZT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G54953IZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54968VQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54970OI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G54971WD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G54994IG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G55006MX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G55019GV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55025YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55026LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55037II", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55043JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55051BJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55055JS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55091DF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55102GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55104BW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G55114PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55126WZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G55135NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55144QZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G55146EO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G55152EE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55174HS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55177GW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55180PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55192YV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55205VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55223IP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55252QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55259BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55282VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55299ME", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55331YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55340IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55353EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55368WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55398ID", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55402MT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G55407TJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55459AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55459MJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55464VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55480NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55487QV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G55492KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55494GF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G55507CF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55514LR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55529NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55550BB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55559HZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55560NP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55567ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55578JG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55592QU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55636WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55638XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55664FE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55675FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55695AY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55700PF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55728EM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G55753QM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G55777FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55823NJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G55838UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55866KK", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G55870EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55880FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55925AY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G55925JJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G55964YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55967EP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55975RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55975YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55986UN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56011JM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56033WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56042JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56044AQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56067ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56077PT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56111FM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56186MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56194FV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56200PW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56202KK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G56221OY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56245IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56248SW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56256KD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G56267PD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56270HP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G56276UW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56285KF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G56292BI", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G56293JI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56295OD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56296MY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56299XO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56315MK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56346ZN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G56404GH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56418NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56427WT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56480ZT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56485ZR", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G56489QW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56493QM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56498UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56502CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56506GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56517QL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56529CD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56556KH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56575BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56657VE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G56675EV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G56676XV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56682BC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56697EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56699NM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56731XW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56734EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56767LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56796RC", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G56803IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56829ZH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56831HO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56852MM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G56878YW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56882GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56913CG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G56920BC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G56936OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56946CM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56947WF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G56961QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56973FQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G56979BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56987FT", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G57007FO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57030TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57046HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57051HS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G57051UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57061PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57063AY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G57068ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57073DH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G57092PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57120NC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57130DY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G57130XG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G57144YM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57183BI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G57184TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57226OB", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G57247BR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G57249PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57253BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57262IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57276IQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57296XM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57313ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57321FI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57330MO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57335GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57340EZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G57385MA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57385TO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57387RD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57399TD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G57415BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57447MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57471CR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G57482YT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57505PZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57510LQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57545VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57558XS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57568CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57591KJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G57592QM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G57598XN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G57610OS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G57672ST", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57692HM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57723XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57734UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57753FT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57755LH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G57772TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57777JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57778QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57803ND", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57808QW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G57832UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G57836JM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57840ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57843CW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G57857CB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57872KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57925NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57930HQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57938VY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G57940FP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G57949TL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57965EF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57971KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57993RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G57998VW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G58006UM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G58028QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58061QH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58066JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58078TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58106KY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58145JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58180BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58181OH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58195CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58201OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58240EV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G58267EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58272ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58276QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58293BE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G58297AS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58314JG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G58325KK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58362DI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58368SN", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G58386YP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58402CL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G58414HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58450MK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G58469ZS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58473ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58477IT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G58486ZT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58489WT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58489YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58501OI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58511VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58537BJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G58539KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58543HQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58577QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58578BZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58580BP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G58582XO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58590MR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G58620PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58634ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58645HA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58660DS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G58670TY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G58683GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58695FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58697JA", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G58699XL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58699ZC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58701XD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58740DK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58759ZL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58776MY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G58793GF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58806SQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58810QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58814JC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58814TJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58815WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58825HG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58837QJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58846EV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58859HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58870KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58871OJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G58878NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58890ZT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G58952ZX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G58959YB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G58972RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G58972ZH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G58980RJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59031ZJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G59035KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59044CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59052WJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G59068XW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G59097RP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G59103LK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59111AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59130AK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59133XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59155GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59179MY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G59212FY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59216UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59280CO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G59287RT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G59306VK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G59332RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59362TA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G59362UD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59379KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59392WK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G59417ID", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G59432AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59479IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59498PG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59505RO", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G59528VC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G59529EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59544AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59548CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59576RD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G59587GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59588ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59595AB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59635FY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G59644LY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G59658KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59659CN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G59674PZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G59684RH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G59701TN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59712UJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G59740UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59745LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59746EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59747EH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G59757WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59804FF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G59817AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59821JJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G59833AV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59853RL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59862RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59915RO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G59930AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59937NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59944EN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59951KW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G59969VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59970QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59973RN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G59999BN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60010FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60057HO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60059YM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60066HN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60067UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60087UT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60090VO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G60127MT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60128FW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60138JZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60149XJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60190AL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G60199VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60219RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60231EF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60234BX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60273TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60275BG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G60282OI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60321GY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G60323NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60324UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60341PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60361PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60403CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60414ZR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G60425OM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60426XC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60437DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60441MD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60457MA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60461BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60515CZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60527GH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G60558WQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60564JX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G60567MY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60598XD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60603HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60615ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60625SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60626AG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60638AI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60638WA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G60673FL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G60687DB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60725IW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G60729FR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G60731ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60734PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60735SE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G60740GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60741OC", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G60755CL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60759PA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60799ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60833BB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G60844ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60852ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60864NI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60883HN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G60884FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60890ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60895UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60912CW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G60920ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60925RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G60949GI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G60955ML", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G60965JU", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G60977LC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61009EJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G61011QL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61044YD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G61072JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61073CA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G61078TF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61081DV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61089HL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61090QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61094XY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61108WE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61116DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61119KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61155XS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G61159LY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61176JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61191HU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61238HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61281CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61311ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61314HT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61339UO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61341GD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61350QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61358KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61367OF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G61392DS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61406KC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61411XJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61424DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61426YN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61431OM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61442IL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61459KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61486JC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61501FW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61503ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61538CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61547RR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61559VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61582HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61588MG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61625UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61633GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61672HK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61715VD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61724IO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61730RY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G61747RH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61757FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61778ST", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G61780GR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61786HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61788PW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61823QH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61833XV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61886WA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G61887JK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G61887VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61889LW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G61906XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61918NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61921AV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61929YU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G61938MK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G61944AL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G61972DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62001NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62002KG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G62007JK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G62007UG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G62014UA", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G62014YU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62015ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62044IM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62044ND", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62055DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62070TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62074KH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G62081IR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G62086ZV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G62138GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62146JX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62149VQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G62159SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62165LJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G62182KD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G62189UN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62217NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62218ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62221RF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62243CB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62244TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62252OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62274IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62278MB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62311FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62355RX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62382LX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62384BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62400VU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62401LZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G62407IF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G62414VY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62418LM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G62437NU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G62440QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62449EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62469XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62471ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62531KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62533XK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62549PS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62558LM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G62567KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62568FD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G62574YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62577TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62613QD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62621XS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62632ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62642QZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G62680DG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62680UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62713BK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62741IO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62765JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62820PI", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G62824TL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62861MP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G62870QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62882LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62904LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G62911EF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G62980KY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G63020KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63083UK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63110FE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63135DD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G63161GM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63188OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63193BW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63193FF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63194GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63209WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63213PP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63231BS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63241SG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63242HY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63251EV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63258OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63286MF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G63295GL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G63303QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63309YY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63317CA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63324SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63326CP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63327EC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63327FD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G63329SO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G63334FZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G63342TJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63343WQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63349JM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63361NH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63377SE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63383SE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63388IH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63404EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63405JW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63416WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63427CD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63438BO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63438EB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63443GA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63444WV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63452MH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63461XJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63468HF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63474NY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63499JS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63505HS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63519GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63525TE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63527PL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63550TC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63570GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63580II", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63628UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63646FQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63660JP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63664GB", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G63690PS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63716UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63717SU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63727WO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63748AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63754TT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63787FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63791WF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63794QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63826DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63830GM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G63842WA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G63845LK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63858YS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G63930KA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63932ZM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G63946SF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G63952EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G63978FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64002SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64008QI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64029DP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64050LH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64054WF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64055WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64061QG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64068RC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64102JR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64106XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64111DY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64122IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64157NZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G64164CA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64165TJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64171LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64200LI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64206XB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64239KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64241WX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64242OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64252WT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64274SJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64285PF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64305XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64354IV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64377MH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64404HO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64414BV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64450GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64454AV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64458EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64459DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64463IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64468GG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64476AV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64482PB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G64485VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64504HS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64527IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64535ZF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64553RA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64560HC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64563CQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64566OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64575OQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64577HA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64581FT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64604UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64610UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64613CO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64617OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64662EI", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G64684RR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64712UU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64774WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64787HE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64813IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64839PV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64842RE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64844ET", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64849QZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G64851ON", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64852XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64860QW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64878VD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64881OC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64899EB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G64904FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64904QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64905PP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G64931FF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64937TE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64963GW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G64965PX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G64973KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G64981YW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G64996BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65012NY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65026YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65037OI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65070OM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65076KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65085NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65112YQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G65124UZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65135MY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65137ZN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65162CH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65169LC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65180FA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65191ST", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65200OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65224TC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65225VD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65234FH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65237AB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65249DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65253JD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65262KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65263TV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65268SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65285QO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65288NK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65315WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65321MY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65321RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65343GU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65345RD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65347HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65348IZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65351EL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65363PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65364FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65365ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65369IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65376QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65396UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65400TP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65408JY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65446KH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65447BW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65460ES", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G65464AD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G65499ZI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65549NV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65562ZE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65579KI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65593FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65600KO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65602FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65609NG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65660BL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65667PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65669BM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65704VY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65715DK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65728QH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65777NT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65790DQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65796IY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65796KU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65800DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65805JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65808UZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65809MG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65815BT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65837AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65852GY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65860PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65867LM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65890NG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G65895VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65909WP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65933SR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G65955VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65962JE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G65967AW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G65978JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66013IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66021ZE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66030KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66038TP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G66040GE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66040YD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66055IE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66076QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66123IE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66154CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66160FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66162WI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66166BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66169TD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G66184ZO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66188DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66191UP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66205CG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66213WH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66225EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66244VX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G66253BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66255YY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G66271TT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66283JW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66284CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66289YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66301VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66307BZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66349AX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66360FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66367EU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66405LD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66414OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66418NO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G66419SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66421OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66435SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66460UY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66489LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66505YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66509EZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G66512FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66524AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66544EE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G66545QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66552NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66576RC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66605YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66621SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66632SG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G66646CU", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G66651WU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66654PP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66662KA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66669IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66685LA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66685ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66699QG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66711OC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66722AJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66723JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66741QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66772SE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66788MF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66828DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66830UP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66838AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66858BS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66867PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66872WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66874OD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G66887YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66888DD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66917BW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G66923LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66945SJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66959DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G66961JH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G66967KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G66977DX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66991YE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G66995XV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67019HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67046QM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G67053LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67061AB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67080ES", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67129FV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G67174VO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G67195ED", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G67200RM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67208MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67212WQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67251TG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G67251WU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G67255LY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67256DS", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G67263AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67265VZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G67274NW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67277GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67281LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67293HE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67300CR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G67306YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67310PZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67326LW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67354ZM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67371HE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67384JS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67384KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67400MO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67405DY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G67407NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67432KX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G67451GS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67466TY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67471ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67481WJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G67499HP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67534CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67561OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67571VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67586UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67590LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67624GB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G67642QF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67646YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67650WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67682CC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67682MC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67686RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67693JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67694IK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67695RM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67697EV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67731YT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67772KL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G67775HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67776GW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67779EA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67796SA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67797LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67815NN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67821CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67825LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67839YV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67878YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67883AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67893HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67899GK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67902NS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67920QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67923GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67935MX", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G67949RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67959IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67966GD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G67969CT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G67980TZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G67984UO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67987DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G67997AX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G67998OP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G68007WG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68008QO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68038KC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68043EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68053UD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68062BK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68066IG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68072QH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68074JL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G68099MP", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G68107IH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68132LA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G68133RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68145BY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68175FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68178AA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68186HL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68190BD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68200GL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68207KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68210RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68215ES", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68232HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68253RD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G68264WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68268VH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68286QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68290RT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68306RK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68308SZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68310FJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68316FE", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G68338CE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68373VW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68384KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68391RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68412PR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G68458SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68480EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68490DY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G68523WA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G68529CM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68529LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68541BJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G68550ZM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68563JG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68596UN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68614NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68636XD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68637SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68639VP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G68646SF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G68667ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68672OT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68686HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68694JF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68707XN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G68713BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68721DM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G68733PD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68776NM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68792QL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G68806LA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68820TX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68881YW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G68893BQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68893PY", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G68894XH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68897ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68905CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68914XE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68924IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68931EB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G68940KR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68951DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68956JQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68964XC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G68984AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68986CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G68987LV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G68990TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69003EQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69022KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69024AW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69025XA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69033GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69052CM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69065FL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69093SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69096ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69099KE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69118GP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69126NO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69137GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69173KW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G69176ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69185XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69189FV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69204PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69228BH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G69229KW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69230QH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69233PF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G69261IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69281GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69288VJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69327YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69345JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69349ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69375AJ", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G69397VF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G69406YD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G69408ZZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G69420JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69440CJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G69443HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69445ZX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69446XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69453HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69476MK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69479TC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G69487NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69500TM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69553SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69554ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69585DZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G69616MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69627IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69631DE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69636EJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G69683VZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69685RI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69689ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69715ZH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69723CB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69735UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69738KH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G69748HU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69748TK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69751PD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69762CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69762TP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69765IW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69774ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69788BR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G69808IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69822EU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G69824GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69831AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69837XX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G69876CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69890SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G69897TU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G69969LR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70025ON", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70030ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70048IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70062NE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70074GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70080NT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70081ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70097NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70122ZE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70125XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70146PH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70186NT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70224LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70228DF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70288OC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G70323JV", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G70332AA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70347OW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G70362WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70386XL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G70421MD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G70422TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70444FA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70479DP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G70494NA", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G70497TX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G70520NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70528XB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G70538OR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70539LS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70568SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70572KM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70572KX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70579MZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70582LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70587KR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70590VH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G70611DW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70620WD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70623QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70631UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70634FN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G70647PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70648DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70649KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70651ES", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70656EA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G70658PP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70688TC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70693FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70697FM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G70751QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70776TD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G70783BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70795HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70815NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70839YE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G70857WY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G70881GH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G70912PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70919RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70928KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70943ER", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G70962SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70976HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70980PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G70985IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71016LJ", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G71031QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71037KV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71041DQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71057CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71070JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71072JD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71077LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71089OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71091AL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71091TJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71093FQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71094KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71107CC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71121NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71133TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71138QD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71139HJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71159AI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71165VR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71174VV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71202JE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71222KY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71229DV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71234WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71247WG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71249CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71275SD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G71283AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71304WV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71305OT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71306LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71307CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71313AZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71326BY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71331ST", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71338QU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71362YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71378JW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71388VQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71391WN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71398ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71403JN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71409LF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71414GS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71446UK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71455DJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71461JM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71479KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71487ZS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71494LB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71502EE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71506JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71511JI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71520GT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71525IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71528GY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71538OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71549TN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71575PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71586EH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71599VG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71620LJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71620VO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71624ZZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71680KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71688TU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71695GL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71698NY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71703UN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71707QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71713QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71719NW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71725KE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71767XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71773FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71816WC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71832QJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71832WA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71835SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71839WD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G71847NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71847XW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71910GL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71913HX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G71918PA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G71951OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71953WK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71958XX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71961AV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G71964JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71966PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71969OB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G71989CT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71990XF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G71994UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G71999UY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72008IY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72041CH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G72069QX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72070EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72130HX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72154SP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G72175XZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72207TE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72246LI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G72261BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72263DG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72279PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72287LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72289FX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G72298WI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G72303HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72304KR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G72319HC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72319UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72336LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72356ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72379PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72405RM", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G72446TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72452LM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G72484IY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G72526DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72539TP", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G72548AI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72554ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72558UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72574NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72579SX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G72596QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72603ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72614KG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G72620YF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72647JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72647WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72648QI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72656BW", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G72665QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72673RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72693SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72729HN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72734AU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G72735TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72736BF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G72745SQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G72779EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72790LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72790QJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G72827OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72828HZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G72830DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72854ZT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G72879CL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72900AG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G72902IR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G72911FU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G72914LC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G72929XF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G72935VB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72959NR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72986IT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G72992IV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73019DE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73029NN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G73033IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73076IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73077ZO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G73162BZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73168SJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G73184QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73195UA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G73200UX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G73203OQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73209SM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73215YD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73313KA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G73318SN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G73323VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73328UF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73330CF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73344QV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73351YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73373AY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73382HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73394KQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73410LR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G73423PD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73429NT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G73432XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73440TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73481KW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73487DJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73507OJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73507OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73510WB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73522II", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73544PN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G73573VW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73574DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73576SB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G73582RP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73609FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73616UE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G73653TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73663RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73678DS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73707DO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73723ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73748DH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G73749NZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G73760YR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G73809WP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73819QW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G73829NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73851KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73857XE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73862MD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73882WS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73883TP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G73898EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73909ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73913LV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73938VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G73941VE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G73971ME", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G73988HM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G73991ZU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G74012IM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74020TX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G74038AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74049SP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74084GS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74114HO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G74130BZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G74130TT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G74163WT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74176HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74179EL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74206UC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G74225AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74226VD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74228BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74241QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74242PX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G74252EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74286WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74287RU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74294TP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74307LW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74307VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74318WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74324NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74339LA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G74340SH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74376RF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74396CO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74410JX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74426IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74440VS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74463NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74471QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74473MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74484ON", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74489AS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74491LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74503BE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74532PT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74542HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74555XQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74589YB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G74603OI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74607VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74626LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74632FV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74632SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74642TI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G74678FD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G74678YC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74679FP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G74684ZW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74699ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74701OU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74702CZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74714MV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74724PV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G74758HW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74760GM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G74770TW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74782FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74785LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74790FN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74793LO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G74799WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74808ZY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74814JR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74827ZJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74836XO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74855ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74855JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74855SC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74878YV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G74917JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74918VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74929XO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G74941GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74945NC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74950DJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G74959QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74960IM", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G74975UG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G74992YO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75011MA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G75017TA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G75031OT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75032PM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75039PU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75042KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75081UH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75113PZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75120QY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75121VU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75153EW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75168BA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75171WW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75178DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75192PM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G75212LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75242PD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75248WN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75300HM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75321RS", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G75324CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75339KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75347TP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G75376YT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75381CL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G75389LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75398QL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75407RU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75407SV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75408KS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G75453GL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75462ID", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G75472OU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75480QF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75483WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75498OJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G75500ME", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G75510GI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75518WT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G75528JJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75547HK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G75549SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75563VE", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G75565BZ", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G75583KV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75584YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75586OT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75594JP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75597IN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75599HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75621PH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75637RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75642KI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75646NW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75648IS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75650VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75655AB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G75687SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75701WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75704MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75709RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75717AV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75726JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75748QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75749JP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75783XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75786FQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75828CP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75834EU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G75842YX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G75851ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75868SR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G75905JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75906TR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G75924IA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75927LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G75936VJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75974DW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G75975LI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G75999PF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76020RM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G76031FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76036GS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76082SD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76097GZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76104SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76133WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76154QC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76173TA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76200OU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76213KN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76214JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76243MI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76247UK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G76299ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76317AM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G76330SV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76343XZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76351FY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76355TG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76362LL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G76370WH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76385PD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76387IG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76389HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76420FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76429IN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76431SN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76459ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76465IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76470HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76481US", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76500NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76505ZE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76524PQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76525MF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76526WR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76544YY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76561LL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76599ZT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76603DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76607YV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76614XW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76636VL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76703CC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G76725JQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76726PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76748ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76763LN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G76789KR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76844PH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76855CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76863NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76874HM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76876LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G76881UY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76910CD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G76962UC", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G76974OT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G76986FH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76993QS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G76994RW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G76997PL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77000EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77063JN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G77065ZV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77076CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77078YI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77095CK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77101QR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G77109JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77122LF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77136XW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77141HO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77149IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77151XM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77194JD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G77208XM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G77211VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77213YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77218JF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G77259GO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77264UN", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G77311AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77353TH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77395DA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77400TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77413CE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G77477NL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77481LZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77497MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77503IE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77515ZX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77535NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77546PH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77550KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77555YU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77557JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77590TW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77597MJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77627AJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77628RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77633IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77646IY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G77652GC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G77674IK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77685SR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77690ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77696IB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77727WY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77740PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77757UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77792ZA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77814AS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77843RR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G77851XO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77864MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77900OU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G77906ZO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77915WT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G77937PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77938VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G77938WM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G77945NE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G77960OV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G77967JJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G77970DT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G77993ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78011OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78016MI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G78032US", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78033ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78034SR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78056MI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78104ML", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78106KK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78108ZM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G78122DT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78127DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78134HQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78156NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78202HA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78239OD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78241UJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78248QX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78262KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78263WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78293EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78306GH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78312BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78314LL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78315BS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G78315FS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78333MH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G78369LH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78372JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78429YP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78436BB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78450WR", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G78475DU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78482II", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G78482IS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78519JI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78533WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78592EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78617GO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78641UQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78657XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78668AS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G78695ET", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78698EP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78713VS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78729FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78734OE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78742PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78744AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78757VY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78759XX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G78767YD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78768PN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78778QM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78783JO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78788QJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78789AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78792AJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78792RY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78811IE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78830IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78843SE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G78856SO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78859BS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G78880TG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78900SX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78915OI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G78918BK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78928PU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78930SC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G78990OC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G78992FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G78999VN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G79011EQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79017QZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79019WG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79021MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79021WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79034WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79035QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79039LV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79056JA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G79083TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79093TF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G79120BW", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G79137TM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79150MP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79151XT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G79168SD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79177TQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79222ND", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79224KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79243QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79246GM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79254LX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G79301TW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G79308EQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79311OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79323CW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79364NZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G79372AN", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G79384AQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79385UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79388TI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79464QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79492YL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79562FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79566BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79578AN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79600DE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G79619FY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G79627VE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79690CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79718RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79730DI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79735PS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G79745IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79749ZY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G79762CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79762KQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79763SM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79764DY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G79779MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79787PB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79788QE", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G79798AT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G79828LU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G79855KD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79878OX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G79889QN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79890WA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G79913NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79915IB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G79968EZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79976GJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G79991RJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G79994XR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G80027ER", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80055EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80068SW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G80106WE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80111QD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80118LE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80147HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80148RS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80164MG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G80176YK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80187JE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80187RV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80188JS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80204VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80209RM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80214IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80217RM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G80228HI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G80235JY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80251DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80281PU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G80288AX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80306SV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80308BA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80316IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80325WI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G80343TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80345NV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80346ZU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80362CW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80367EB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80396YJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80399EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80403NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80418BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80418WK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G80425FZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80428YE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G80434TI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80479HQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G80483TF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80484RY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80489MK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80509FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80511NN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80562EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80565QS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80569VM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80569XM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80577JZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80577OW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80586FE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80618TG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80643JD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80649OD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80667HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80678HX", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80690PN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G80692PL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80700YJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80708VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80719YH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80726UW", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G80729IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80736RG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80738BU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80738PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80758JE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G80762WG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G80777VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80778GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80787JJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80874VF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80879EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80884ES", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G80903UK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80903ZD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G80951VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G80960YD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81002OL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81013HU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81016SV", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G81041HS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81082JG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81096BD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81112MA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81115FG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81126MU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81167HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81213GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81214EK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81217LD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G81219YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81221QB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G81225OR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81272FZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G81303NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81370GY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81371RJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G81420KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81439BR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81466NG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81471KU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G81473HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81520BE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81534KB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G81541IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81568VW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81598AZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81628EZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81632WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81680BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81702BT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G81725CS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G81748GB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81753IL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G81759TU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G81778DU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81787XH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G81797TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81825YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81832CY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81832XS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G81844SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81881TF", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G81902IO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81909AL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G81921LU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81944UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81962WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G81991FU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82028JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82049CD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82054AK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82058GP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82083TQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82092PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82110XO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82133EG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82147MI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82152YZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82155DA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82175BQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G82186ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82195SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82216JH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G82222XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82243CK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82249SB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82251ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82264VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82267MT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82285OB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82286VD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G82305SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82317GV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82324DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82334OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82354BQ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82362HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82363EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82366DK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82370DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82379LH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82393KC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82406IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82407GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82412EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82412NE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82426OW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82427FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82437NT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82463EY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82469TL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82512PT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82621TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82638QD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82651UV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82680GQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82680KA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82693QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82698QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82699CV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82700SN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G82714WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82724OR", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82737ZO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G82785ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82790IO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82806QI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82831RJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G82840TE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82862JX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82870SE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82881HF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82882LR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82905PO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82906DM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82913AR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G82913EE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G82947ES", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G82947LB", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G82950HY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82952OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G82970CD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G82987BA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83009HN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G83015GK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83029ZD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83048UX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83068AX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83080DP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G83092KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83103PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83104JJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83120VA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83134ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83140GU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83155KW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83192EO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83206CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83232LD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83238IZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83241PZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83244OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83261UB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83344UL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G83362WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83364CQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83412BV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G83412LT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83423NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83432YR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83434MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83476KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83479LG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83480VO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83483MN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83491LR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83495JN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83502DX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83514WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83517DN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83519QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83524RP", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G83546KK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G83561CI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G83565AD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83567OS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83580CS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83620XJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83623GP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83643ND", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G83646AE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83694JC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83697JV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83700KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83719UD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83732YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83736YU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G83740WV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G83754KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83781BA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G83808HF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83827QM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83831AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83833YG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83843GL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83885CD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83894HO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83897FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83920DK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83928VU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83940OS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G83944UI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G83950JR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G83952ID", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G83997BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G83998HE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G84003GC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84010XP", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G84032TK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G84064VM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84071MB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84122DM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84146JE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G84147VQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G84168WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84182AF", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G84184XU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84205RB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84228OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84243HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84264WM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84273UX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84275GW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G84277NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84279CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84285WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84332AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84360YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84366AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84398ZW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84459ZZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G84466TC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G84502HG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G84503DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84504MZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84507CY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84515GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84517LG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G84532IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84539VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84550DH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84559PU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84571QT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84579JI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G84596RP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84641CT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G84646MS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G84647SC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G84662EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84663MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84675XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84731OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84800MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84818UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84821OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84822FG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84823QS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G84827GB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84853WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84880FB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84884IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84906AJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84906ML", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G84910XD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84917IA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84919ZX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G84958AF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G84969LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85002XD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85020KV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85039TI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85049LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85052OU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G85079IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85083RQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85121CV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85145NA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G85174VD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G85180ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85213IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85213NF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G85214AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85231EY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85243CH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85282JA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85284LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85284MK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85302NF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85310SF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85313YF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85315VP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85342DQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85343TN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G85357PU", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G85366AQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85366II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85389AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85392NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85393KI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85411LG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85431OK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G85445QG", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G85463RK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85483NO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85490MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85493TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85496BH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G85540GM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G85545QE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85548QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85578HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85595RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G85596OS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85608AG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85618IE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G85630KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85633MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85670FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85714GY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G85721WE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G85734JO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G85736BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85774KQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G85821PU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G85828UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85851IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85862MS", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G85864UD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G85887XT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85890AG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G85899UL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G85907UO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85924HA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G85947FY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85971OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85972OZ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G85972YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G85977BN", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G85997RC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86002IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86013XY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86050NV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86069NX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86072HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86082YL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86083AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86085BW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86085HN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86117ZB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G86118SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86130AV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86164WK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G86167MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86173MX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86186US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86193XM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86196JH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86198MF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86199GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86206OP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86221TG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86227LF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86239DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86248YA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86294AN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86300ZI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G86304WJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G86320XR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86330CJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86354VJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86365HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86372GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86375CM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86387VT", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G86389LM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86407VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86443JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86450IC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86454PA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86469VE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86472WY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86480FG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86499WY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G86533KK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86537AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86557DD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86571PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86574WP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86584AI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86627OG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86634NY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86654VS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86655NE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86656HK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86669AN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86682HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86702JK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86718YQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86728DD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G86732WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86733FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86736BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86737YW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86738PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86742LS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86750UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86782PI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G86783GV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G86838HC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86861MW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G86871XB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G86889SJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86908OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86917QS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86944DR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86947FH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G86948NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G86954HB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G86979CW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87014UA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87019OZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87030ZZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87057NG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87063TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87103TP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G87124AC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87157JK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87218FV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87244KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87249CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87253VG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87256FP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87280CM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87293LX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G87310ZF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87313SD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87328UF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G87360YD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87418QZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87420IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87444MS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87459HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87493YB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87514QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87528ZH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G87570GQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87574LM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87615UU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G87628EQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87648QA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G87649DU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87666TN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87676CC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87683NV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87755UZ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G87756AW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87758PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87772NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87779WY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87797TV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87808DX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87819IQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87847UQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87925KZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G87935YG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87945CD", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G87972UK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G87984PA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G87996EB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88014YP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G88035KQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88038KU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88043PD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88050IP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88055WY", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88089UV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88097LH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88122BX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88139CF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88142QX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88143XD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G88162NH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88184ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88188XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88204LN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88212BS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88216WD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88230UV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88233EF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88254XP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88256EZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88263BY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G88268AZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88274IU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88286DF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88286KJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88313DY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88336BP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88347ND", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G88356CV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88357PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88366YR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G88371FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88376DR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88381SG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88386KM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88388NU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88431RN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88432QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88448RB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88449YB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88457GX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88463NE", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G88464ZX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88486YW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88500KL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88505QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88508SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88518CI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88525XI", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88528AI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88541AN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G88557YZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88567RB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88599FO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88609PK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88624YG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88635SO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88641OZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88642TF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88678EQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88687UE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88689KL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88695TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88696BY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88708RX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88721JO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88725FA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88743SZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G88759BF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88770MJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88776LK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88780VN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G88787RV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G88796VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88815IR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G88828CK", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G88830DA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88837PJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88843AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88850TN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88856QG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88906FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88908BO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88936JZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88938QF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G88955WS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G88975RE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89009CR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G89010BO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G89019WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89026DU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G89058HG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G89058LG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89089XB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89104MS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89107UR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89119ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89129AU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89136NX", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G89137AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89169IY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89182DO", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G89210OT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89215CC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89230YO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G89233QM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89242LQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89242PW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89257WJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89270VP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89278UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89315II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89328HG", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G89337EE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89354EL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G89355NY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G89380NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89398MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89477FF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G89524PP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G89536HI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G89541GZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89544LF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89570VS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G89585FG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89586YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89597IJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G89603EU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G89605NX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G89609RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89611JH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89646CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89649RN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G89661WR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89720WL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G89721BJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89748NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89749SX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89753PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89769RM", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G89798IM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G89803II", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89816MU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89854YO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89870ED", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89870OL", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G89897ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89899YC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G89928FY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G89946SW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G89948OA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89973QY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G89978WX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G89990JE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G89996XH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G90000ZH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90011DC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90011PP", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G90047IV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90054DB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90057EW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G90077BJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G90079WZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90098HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90103MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90135ZJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90146ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90153WX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90182FM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90205AB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90221FQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G90233EO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G90242XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90244OP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G90251SV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90295ID", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90298QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90310QP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90310YO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G90334GI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90350EB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90351WW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G90375IE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90402OU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G90423CD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90436CB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90439ZM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90451QF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G90479ES", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90487UB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90494RK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90510OM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90529LH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90561GD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G90572ER", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90575VK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90628RS", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G90630JW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90634OE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90639RS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90657JS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90684PC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90689AW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90719NY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90724OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90739UE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G90743KX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90746ZG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90754EO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90767ZX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90771OP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90771UI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G90788JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90789UO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90791MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90794QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90816KP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90818DN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90829NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90877FW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G90901EO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90903RC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90926WR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G90928ZN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G90935OH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90936JJ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G90952OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90965BZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90974OV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G90999PU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G90999QY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91016QL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91017HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91021AJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91041PO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91043NZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91047NA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91067ZR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91069QW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91083FL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91093AL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G91124TR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G91135NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91143IL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91144VS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G91151HA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G91161VR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91166AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91181WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91184FE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G91191RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91227PM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91227UA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91236EO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91313DF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G91322OS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91368WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91392GZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G91410ZU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91447PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91459EI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91474LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91484JV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91484XT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91509JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91523GT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G91561TB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G91563MR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91583LA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91596AH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91618RS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91627PX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91637SF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91659ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91662EF", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G91669BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91684MM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G91687HB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91724MB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91731DX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91732VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91738GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91756JQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G91757WO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91775YA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91777HP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G91786NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91788FV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91799SO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91803IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91807FJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G91809FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91827RZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91843YE", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G91863BD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91875JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91881LP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G91883RB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91898TC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G91945VH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G91965NG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G91990OC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G92017SL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92019ZO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92032WO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92097UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92115PW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92115RL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92127GC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92130WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92142RG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92155IO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92175OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92179IH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92184RD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G92190YN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92194JK", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G92215RW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92225FJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G92232VN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92252GS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92264YI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92281IL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92288VL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G92296LB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92302BV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92318PO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92324IJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92327HS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92332SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92332WW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92333JS", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G92345KY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92354TO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92358PV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92378XH", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G92388MC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92389OS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G92399AI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92399PD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92399RB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92410QB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G92424DL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92440ZF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G92444JZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G92485YK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92487PT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92490QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92500NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92501LD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92509CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92593OX", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G92594CB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G92666GK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92694MO", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G92716MQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92734HI", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G92740EF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G92796NN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92797EC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92808AT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92829RR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92834ME", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G92838RO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92928SW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G92933OP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92933SR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G92980WM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G92982UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93000QZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93045SX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93073GJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93088DU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93090IR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93160RG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93184BI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93191IF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93195AE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93213IL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93227HA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93239VC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93242HC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93258UI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93270TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93278FL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93279YE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G93296CH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93309ZC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93333OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93337VO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G93346ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93364WV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93365WI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93389TU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G93450CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93461HH", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93470LV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93476UL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93493GN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G93503MM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93505VZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93515DH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G93520MA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93523MF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93526OI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93533JW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93542QZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G93543SY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93560KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93577ZC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93592ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93596GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93597FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93612TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93612YS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G93626XM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93627NS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G93630PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93636BY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93691AZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93692RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93696JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93706QR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93763TV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93774RM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G93774WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93791KT", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G93801LA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G93802CF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G93814YA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G93825UP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93828IC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93830FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93861DJ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93861XR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93867XX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93909NH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93910CU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93911DY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93924RQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G93935AM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93941QH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G93948SP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93984MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93987XA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93994EV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G93996ZB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94005KC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94025TC", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94058TU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94062FP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94070ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94072JB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94085VM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94092LO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94146NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94161VQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94178IQ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94180RN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G94216WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94217FB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94222CK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94234FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94244YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94260JY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94264FX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94285QA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94304ZN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94306LD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G94351CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94352TY", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G94374SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94397HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94416QP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G94435QH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94442KU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94449FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94470EI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94477RP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94502LK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94505FR", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94510EL", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94514IB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94517VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94541HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94566ZN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G94577KW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94586KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94593TA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94595ZZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94599CR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G94599QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94615OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94618YC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94621HP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94627QP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G94677FK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94682VY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94705OR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94718XM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94722MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94768NG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94791MM", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94808GT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94808XV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94817WU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94824OK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94849XM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G94850BN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94850KK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94854QH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G94855OA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G94895HH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94900KH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94906EX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94925SE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G94930MP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94938LU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G94941PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G94971CC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95003CS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95006CL", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G95035TM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95054VP", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G95114RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95144UL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95151JF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95159TE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G95259QI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95273RH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G95292IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95304AA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G95324VU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95329IQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95343SU", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G95353IZ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95370BC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95397YW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G95415HZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95430GC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G95438ID", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95448VV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95455DG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95509VI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95515SK", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G95518AM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G95532JO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95560ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95586IZ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95593KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95615QI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95620GE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95648NB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95664HQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95675JM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95698VF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95706CX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95715FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95715NY", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95739UA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G95739WE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95740GH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95763TD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95776WU", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G95809LN", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G95812KU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95872RH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G95889EP", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G95890CG", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G95915TY", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G95925PE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95936DV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95961OC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G95963UH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95981KO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G95990QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G95994QZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G95997AL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96005ME", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96017QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96018DP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96039NQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96057TO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96066HD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96067FK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96079CK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96093AA", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G96099JL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96105BP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96107WD", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96115PK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96119TZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96142QQ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96169RK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96174JO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G96334ZO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96336FY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96349IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96349RY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96367AD", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96371NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96373OE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96409DQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G96416ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96416NB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96425TB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G96463EY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96464LK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96464PC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G96483ZT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96503AM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G96540EH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96568SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96576RP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G96576WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96588SJ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G96599KT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96600WW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G96622FI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96631UP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96636JK", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G96643WB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96653KP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96663HG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96679EA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96691CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96715CG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96735SK", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96738CW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96746BC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96748VF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96758WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96763TB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96783GY", "type": "O-linked", "subtype": "Core 7" }, { "glytoucan_ac": "G96793JK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96811WN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96812PM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96820VB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96828EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96857WY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96890VV", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96899NE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96902HX", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96914KL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96915PP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96921JI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G96935KI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G96943FZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96950XO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96951LZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G96971EN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96977LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G96984EM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97082HJ", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G97083VO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G97084CG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97118EJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97123YR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97127IZ", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G97154XB", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97160DA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97165QS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97192BE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97213ID", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97227KS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97263AV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97269SV", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97271OF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97316FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97345NY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97347WG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97373KA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97413OV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97420WF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97423YZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97425NF", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97436MG", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97436XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97437DL", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97452SL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G97463WM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97473TX", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97494HI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97515HE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97529OC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97553OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97561SL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97578GB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97582XN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97585KM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97586IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97595JJ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97600FR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97600OZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97608ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97643UW", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97644GG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97647MG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97657WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97763JB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97777ZK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97793RN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97808FL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G97811LK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97834OQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97840DJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97841LZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G97850YT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G97852WM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G97857BW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97860FK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97863GV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G97872RT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97886SP", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G97900CQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97906UF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G97923LO", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G97956ZX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97965SK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G97972BA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G98003WW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98007XA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98008PC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98038DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98073MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98074JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98089PE", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98126OX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98127AN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G98166HB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98166ZJ", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G98200VV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98264BW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98270SB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98279FP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G98308VA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98319WB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98327TQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98340SM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98353BT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98383AS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98393IW", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98412TA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98417SQ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98423LY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98437LC", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98459DZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G98473NJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98477QQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98479SI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98499YC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98518WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98522DF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98525PI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98535LH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98540XI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98541DI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98572QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98579QO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98621JL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G98654DA", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98658WC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98664QA", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G98688IJ", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98689EK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98695CG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98698LI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98744TO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98745FI", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G98753FD", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G98771BG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98786OF", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98795OG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98798WK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98817QU", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G98873GM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98891IZ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98912YW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G98925GS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98940EW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G98944UB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G98950NH", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G98975FF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G98977CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99005CT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99019AH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99039KB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99041WC", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99041XF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99069BG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99137GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99146BF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99163JB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99221NU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99231ED", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G99236CU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99241BD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99244AI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99264QJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99269VU", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G99281CN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99298LT", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G99315PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99329AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99354AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99365LP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99368YN", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99372JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99375YM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99382PO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G99388YO", "type": "O-linked", "subtype": "Core 9" }, { "glytoucan_ac": "G99394BY", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99402IB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99415KF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99419FW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99423WT", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99435JQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99448MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99454KR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99457YH", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G99464KD", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99466GU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G99507PM", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99517NL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99522JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99527BL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99539HR", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99556PB", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99567UC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99571MI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99619WE", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G99632DB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99650PY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99657DS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99667HV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99691UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99709XR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99725YQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99728AI", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G99730GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99738HT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99738PW", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G99752IF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99770FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99772FN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99772YU", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G99783GX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99785MW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99792ZO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G99833CR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99839QA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99893CA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G99938VL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99987ZQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99988WL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99991DB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G99998AA", "type": "O-linked", "subtype": "Core 2" } ], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 170, "end_pos": 172 }, { "start_pos": 593, "end_pos": 595 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N607-1", "uniprot_ac": "F1N607", "uniprot_id": "F1N607_BOVIN", "mass": { "chemical_mass": 29069.0, "monoisotopic_mass": 29069.0 }, "refseq": { "ac": "XP_024838322", "name": "pre-mRNA-splicing factor SYF2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838322" }, "gene_names": [ { "name": "SYF2", "type": "recommended", "evidence": [ { "id": "F1N607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ] }, { "name": "SYF2", "type": "synonym", "evidence": [ { "id": "XP_024838322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838322" } ] } ], "protein_names": [ { "name": "Pre-mRNA-splicing factor SYF2", "type": "recommended", "evidence": [ { "id": "F1N607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N607/entry#names_and_taxonomy" } ] }, { "name": "pre-mRNA-splicing factor SYF2", "type": "synonym", "evidence": [ { "id": "XP_024838322", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838322" } ] } ], "function": [ { "annotation": "Involved in pre-mRNA splicing as component of the spliceosome.", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607#function" }, { "database": "UniProtKB", "id": "ARBA00045277", "url": "https://www.uniprot.org/uniprotkb/ARBA00045277#function" }, { "database": "UniProtKB", "id": "A0A3Q1MFC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC2#function" }, { "database": "UniProtKB", "id": "A0ABI0NZ58", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ58#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYF2", "url": "https://www.uniprot.org/uniprotkb/F1N607", "locus": { "chromosome": "2", "start_pos": 127732104, "end_pos": 127483607, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001651", "url": "https://www.ensembl.org/id/ENSBTAG00000001651" } ] } } ], "crossref": [ { "id": "F1N607", "url": "https://alphafold.ebi.ac.uk/entry/F1N607", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001651", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001651", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522372", "url": "https://www.ncbi.nlm.nih.gov/gene/522372", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013260", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013260", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522372", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522372", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LRMKMNA", "url": "https://omabrowser.org/oma/group/LRMKMNA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N607", "url": "https://www.orthodb.org/?gene=F1N607", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13264", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13264", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13264:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13264:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08231", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08231", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024838322", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838322", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZ58", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZ58-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N607-1", "url": "https://www.uniprot.org/uniprotkb/F1N607-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAATLTEKVPVGGAEEQQPPAGAEELASQKREQRLRKFRELHLKRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKRRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVLDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV", "length": 245, "header": "tr|F1N607-1|F1N607_BOVIN Isoform 1 of Pre-mRNA-splicing factor SYF2 OS=Bos taurus OX=9913 GN=SYF2 PE=3 SV=5 CANONICAL=F1N607-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC2/entry", "sequence": { "sequence": "MAAATLTEKVPVGGAEEQQPPAGAEELASQKREQRLRKFRELHLKRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKRRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVLDLEKQIEKRDKYSRRRPYNDDAERFYGKYTAEIKQNLERGTAV", "length": 229, "header": "tr|A0A3Q1MFC2-1|F1N607_BOVIN Computationally mapped isoform of Pre-mRNA-splicing factor SYF2 OS=Bos taurus OX=9913 GN=SYF2 PE=3 SV=3 CANONICAL=F1N607-1" }, "locus": { "chromosome": "2", "start_pos": 127731100, "end_pos": 127726074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083714.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083714.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069820.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069820.3" } ] } }, { "isoform_ac": "A0ABI0NZ58-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ58/entry", "sequence": { "sequence": "VPVGGAEEQQPPAGAEELASQKREQRLRKFRELHLKRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKRRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVLDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV", "length": 236, "header": "tr|A0ABI0NZ58-1|A0ABI0NZ58_BOVIN Computationally mapped isoform of Pre-mRNA-splicing factor SYF2 OS=Bos taurus OX=9913 GN=SYF2 PE=3 SV=1 CANONICAL=F1N607-1" }, "locus": { "chromosome": "2", "start_pos": 127731100, "end_pos": 127726320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146125.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146125.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107760.1" } ] } }, { "isoform_ac": "F1N607-1", "url": "https://www.uniprot.org/uniprotkb/F1N607/entry", "sequence": { "sequence": "MAAATLTEKVPVGGAEEQQPPAGAEELASQKREQRLRKFRELHLKRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKRRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVLDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV", "length": 245, "header": "tr|F1N607-1|F1N607_BOVIN Isoform 1 of Pre-mRNA-splicing factor SYF2 OS=Bos taurus OX=9913 GN=SYF2 PE=3 SV=5 CANONICAL=F1N607-1" }, "locus": { "chromosome": "2", "start_pos": 127731100, "end_pos": 127726074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002165.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002165.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002165.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002165.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522372", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522372", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AZF3-1", "protein_name": "Pre-mRNA-splicing factor SYF2", "gene_name": "SYF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAATLVEKVPGNGAEEQQPPLGPEELAAQKREQRLRKFRELHLKRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKRRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVVDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV", "length": 245 }, "evidence": [ { "id": "F1N607", "url": "https://omabrowser.org/oma/group/F1N607/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54PG4-1", "protein_name": "Pre-mRNA-splicing factor SYF2", "gene_name": "syf2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSEKETIESLKEEIEIHDRNKSNKGYLPKESYNQVTYDYSKEEEQAKLAHLPKKYLKESENDDKHFIDPLANLTPAQRKVYELRKKLETTKSVIYKSVVDEHKRIHQGAQDEIEEKKRLYKEKIKQEEEEMKKQGLDPQKERLKNQIAEEIKPNKKEKKKDSIVKDKSNTYSDEHVYNSYKKRVKEMEKFHNSEHFKKVVSNEDVKESGDSINNNKYEYGKSIEIPRDNINAMKQELLKNQENRRSFKRKSFKEEEDINYINEENRLFNQKVSRAYDKYTVETRQNLERGTAL", "length": 293 }, "evidence": [ { "id": "F1N607", "url": "https://omabrowser.org/oma/group/F1N607/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" }, { "name": "post-mRNA release spliceosomal complex", "id": "GO:0071014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071014", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" }, { "name": "U2-type catalytic step 2 spliceosome", "id": "GO:0071007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071007", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" }, { "name": "Prp19 complex", "id": "GO:0000974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000974", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "F1N607", "url": "https://www.uniprot.org/uniprotkb/F1N607" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5D4-1", "uniprot_ac": "F1N5D4", "uniprot_id": "F1N5D4_BOVIN", "mass": { "chemical_mass": 108802.0, "monoisotopic_mass": 108802.0 }, "refseq": { "ac": "NP_001359040", "name": "ephrin type-B receptor 6 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359040" }, "gene_names": [ { "name": "EPHB6", "type": "recommended", "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ] }, { "name": "EPHB6", "type": "synonym", "evidence": [ { "id": "NP_001359040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359040" } ] } ], "protein_names": [ { "name": "Ephrin type-B receptor 6", "type": "recommended", "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4/entry#names_and_taxonomy" } ] }, { "name": "Tyrosine-protein kinase-defective receptor EPH-6", "type": "synonym", "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4/entry#names_and_taxonomy" } ] }, { "name": "ephrin receptor EphB6", "type": "synonym", "evidence": [ { "id": "NP_001359040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359040" } ] }, { "name": "ephrin type-B receptor 6 precursor", "type": "synonym", "evidence": [ { "id": "NP_001359040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359040" } ] } ], "function": [ { "annotation": "Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MGK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGK1#function" }, { "database": "UniProtKB", "id": "ARBA00059300", "url": "https://www.uniprot.org/uniprotkb/ARBA00059300#function" }, { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPHB6", "url": "https://www.uniprot.org/uniprotkb/F1N5D4", "locus": { "chromosome": "4", "start_pos": 106180964, "end_pos": 106164451, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015510", "url": "https://www.ensembl.org/id/ENSBTAG00000015510" } ] } } ], "crossref": [ { "id": "F1N5D4", "url": "https://alphafold.ebi.ac.uk/entry/F1N5D4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00185", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00185", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10475", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10475", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529800", "url": "https://www.ncbi.nlm.nih.gov/gene/529800", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529800", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529800", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PQGPSCM", "url": "https://omabrowser.org/oma/group/PQGPSCM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGK1", "url": "https://www.orthodb.org/?gene=A0A3Q1MGK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N5D4", "url": "https://www.orthodb.org/?gene=F1N5D4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46877:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46877:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01404", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01404", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07699", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07699", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14575", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14575", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25599", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25599", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001359040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001359040", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGK1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5D4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5D4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEGAAPSGSRAAGMVGSLWVLALVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAAPGLGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVAGGTCRETFTLYYRQAEEPDGPDSISSWHLKRWTKVDTIAADESFPASSAWAVGPPRAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYACPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGAGGQAAGSSPRLHCNGEGKWMVAVGGCRCQPGHQPARGDKACQACPRGSYKALAGNAPCSPCPARSHALAPAAPVCPCLEGFFRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECGGAGGQGPCRRCRDEVHFDPRQRGLTESRVLIGGLRPHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHAVPSAVPAVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTKLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSAQLPERLSLVVGSILGALAFLLLAAITVLALVFQRKRRGTGYMEQLQQYSSPGLGVKYYIDPSTYEDPCQAIREFAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWTGGAESLQMAFLGQAAMLGQFQHPNILRLEGVVTRSRPFMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFGFVHRALSAHSVLVNSHLECKVARLGRSPQGPSCLLRWAAPEVITHGKHTTSSDVWSFGIVMWEVMSYGERPYWDMSDQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRTQRPHFDQLVAAFDKMIRKPDTLQAGGSPGDRPSQALLNPVALDFPSLDSPQAWLSAIGLECYQDNFSQSGLCTFGDVAQLSLEDLPALGVTLAGHQKKLLHHIQLLQQHLRPPGPVEV", "length": 1007, "header": "tr|F1N5D4-1|F1N5D4_BOVIN Isoform 1 of Ephrin type-B receptor 6 OS=Bos taurus OX=9913 GN=EPHB6 PE=4 SV=3 CANONICAL=F1N5D4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGK1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGK1/entry", "sequence": { "sequence": "MAAEGAAPSGSRAAGMVGSLWVLALVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAAPGLGQDNWLQTHFVERRGAQRAHIRLHFSAEEPDGPDSISSWHLKRWTKVDTIAADESFPASSAWAVGPPRAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYACPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGAGGQAAGSSPRLHCNGEGKWMVAVGGCRCQPGHQPARGDKACQACPRGSYKALAGNAPCSPCPARSHALAPAAPVCPCLEGFFRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECGGAGGQGPCRRCRDEVHFDPRQRGLTESRVLIGGLRPHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHAVPSAVPAVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTKLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSAQLPERLSLVVGSILGALAFLLLAAITVLALVFQRKRRGTGYMEQLQQYSSPGLGVKYYIDPSTYEDPCQAIREFAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWTGGAESLQMAFLGQAAMLGQFQHPNILRLEGVVTRSRPFMVLTELMELGPLDSFLRREGQFSSLQLVAMQRGVAAAMQYLSSFGFVHRALSAHSVLVNSHLECKVARLGRSPQGPSCLLRWAAPEVITHGKHTTSSDVWSFGIVMWEVMSYGERPYWDMSDQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRTQRPHFDQLVAAFDKMIRKPDTLQAGGSPGDRPSQALLNPVALDFPSLDSPQAWLSAIGLECYQDNFSQSGLCTFGDVAQLSLEDLPALGVTLAGHQKKLLHHIQLLQQHLRPPGPVEV", "length": 982, "header": "tr|A0A3Q1MGK1-1|F1N5D4_BOVIN Computationally mapped isoform of Ephrin type-B receptor 6 OS=Bos taurus OX=9913 GN=EPHB6 PE=4 SV=2 CANONICAL=F1N5D4-1" }, "locus": { "chromosome": "4", "start_pos": 106180771, "end_pos": 106173887, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071408.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071408.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069699.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069699.2" } ] } }, { "isoform_ac": "F1N5D4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5D4/entry", "sequence": { "sequence": "MAAEGAAPSGSRAAGMVGSLWVLALVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAAPGLGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVAGGTCRETFTLYYRQAEEPDGPDSISSWHLKRWTKVDTIAADESFPASSAWAVGPPRAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYACPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGAGGQAAGSSPRLHCNGEGKWMVAVGGCRCQPGHQPARGDKACQACPRGSYKALAGNAPCSPCPARSHALAPAAPVCPCLEGFFRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECGGAGGQGPCRRCRDEVHFDPRQRGLTESRVLIGGLRPHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHAVPSAVPAVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTKLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSAQLPERLSLVVGSILGALAFLLLAAITVLALVFQRKRRGTGYMEQLQQYSSPGLGVKYYIDPSTYEDPCQAIREFAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWTGGAESLQMAFLGQAAMLGQFQHPNILRLEGVVTRSRPFMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFGFVHRALSAHSVLVNSHLECKVARLGRSPQGPSCLLRWAAPEVITHGKHTTSSDVWSFGIVMWEVMSYGERPYWDMSDQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRTQRPHFDQLVAAFDKMIRKPDTLQAGGSPGDRPSQALLNPVALDFPSLDSPQAWLSAIGLECYQDNFSQSGLCTFGDVAQLSLEDLPALGVTLAGHQKKLLHHIQLLQQHLRPPGPVEV", "length": 1007, "header": "tr|F1N5D4-1|F1N5D4_BOVIN Isoform 1 of Ephrin type-B receptor 6 OS=Bos taurus OX=9913 GN=EPHB6 PE=4 SV=3 CANONICAL=F1N5D4-1" }, "locus": { "chromosome": "4", "start_pos": 106180771, "end_pos": 106173887, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033428.7", "url": "https://www.ensembl.org/id/ENSBTAT00000033428.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033341.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033341.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529800", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529800", "resource": "KEGG Pathway" }, { "id": "R-BTA-2682334", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "resource": "Reactome", "description": "EPH-Ephrin signaling" }, { "id": "R-BTA-3928662", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "resource": "Reactome", "description": "EPHB-mediated forward signaling" }, { "id": "R-BTA-3928664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928664", "resource": "Reactome", "description": "Ephrin signaling" }, { "id": "R-BTA-3928665", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "resource": "Reactome", "description": "EPH-ephrin mediated repulsion of cells" } ], "orthologs": [ { "uniprot_canonical_ac": "O08644-1", "protein_name": "Ephrin type-B receptor 6", "gene_name": "Ephb6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATEGTTGSGSRVVAGMVCSLWLLVLGSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQADEPDGPDSIAAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTGQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALAGNVPCSPCPARSHSPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRELWFEVQGSALMLHWRLPQELGGRGDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSLVIGSILGALAFLLLAAITVLAVIFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYDDPCQAIRELAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAEGGSGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLLQQHLRQPGSVEV", "length": 1014 }, "evidence": [ { "id": "F1N5D4", "url": "https://omabrowser.org/oma/group/F1N5D4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O15197-1", "protein_name": "Ephrin type-B receptor 6", "gene_name": "EPHB6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV", "length": 1021 }, "evidence": [ { "id": "F1N5D4", "url": "https://omabrowser.org/oma/group/F1N5D4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0C0K7-1", "protein_name": "Ephrin type-B receptor 6", "gene_name": "Ephb6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASENTAGSGSRVAGMVYSLWLLVLGPSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQADEPDSPDSISAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTDQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALPGNVPCSPCPARSHSPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRELWFEVQGSALMLHWRLPQELGGRGDLLFNVVCKECGGHKEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSLVIGSILGALAFLLLAAITVLAVIFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYDDPCQAIRELAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTRSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMSDQEVLNAIEQEFRLPPPPGCPTGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAEGSSGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLLQQHLRQPGSVEV", "length": 1013 }, "evidence": [ { "id": "F1N5D4", "url": "https://omabrowser.org/oma/group/F1N5D4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" }, { "name": "ephrin receptor activity", "id": "GO:0005003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005003", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" }, { "name": "transmembrane-ephrin receptor activity", "id": "GO:0005005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005005", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1N5D4", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 954, "end_pos": 956, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5D4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1007, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5D4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5D4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" }, { "id": "PS51550", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51550" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Eph LBD", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 228, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 360, "end_pos": 472, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 656, "end_pos": 905, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D4" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 934, "end_pos": 998, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 466, "end_pos": 468 }, { "start_pos": 954, "end_pos": 956 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5F2-1", "uniprot_ac": "F1N5F2", "uniprot_id": "F1N5F2_BOVIN", "mass": { "chemical_mass": 53388.0, "monoisotopic_mass": 53388.0 }, "refseq": {}, "gene_names": [ { "name": "BCKDHA", "type": "recommended", "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ] } ], "protein_names": [ { "name": "2-oxoisovalerate dehydrogenase subunit alpha", "type": "recommended", "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2/entry#names_and_taxonomy" } ] }, { "name": "1.2.4.4", "type": "synonym", "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2/entry#names_and_taxonomy" } ] }, { "name": "Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain", "type": "synonym", "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MGN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN1#function" }, { "database": "UniProtKB", "id": "RU365014", "url": "https://www.uniprot.org/uniprotkb/RU365014#function" }, { "database": "UniProtKB", "id": "ARBA00037052", "url": "https://www.uniprot.org/uniprotkb/ARBA00037052#function" }, { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2#function" }, { "database": "UniProtKB", "id": "A0ABI0P3F3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCKDHA", "url": "https://www.uniprot.org/uniprotkb/F1N5F2", "locus": { "chromosome": "18", "start_pos": 50560776, "end_pos": 50541310, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016037", "url": "https://www.ensembl.org/id/ENSBTAG00000016037" } ] } } ], "crossref": [ { "id": "F1N5F2", "url": "https://alphafold.ebi.ac.uk/entry/F1N5F2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016037", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016037", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02000", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02000", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGN1", "url": "https://www.orthodb.org/?gene=A0A3Q1MGN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N5F2", "url": "https://www.orthodb.org/?gene=F1N5F2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43380:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43380:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00676", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00676", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70895", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9859138", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9859138", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "13457", "url": "https://www.rhea-db.org/rhea/13457", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "84639", "url": "https://www.rhea-db.org/rhea/84639", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "84643", "url": "https://www.rhea-db.org/rhea/84643", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MGN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGN1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3F3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3F3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5F2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5F2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGQPLSRRGEGRISEGWSAKMAMAVAVAVARVWRPSRGLGRTGLPLLRLLGARGLARFHPHRWQQQQHFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEKVLKFYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDDTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDLGKGRQMPVHYGCRERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGILSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHHLQSRGWWDDEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLIFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDHFEK", "length": 470, "header": "tr|F1N5F2-1|F1N5F2_BOVIN Isoform 1 of 2-oxoisovalerate dehydrogenase subunit alpha OS=Bos taurus OX=9913 GN=BCKDHA PE=3 SV=3 CANONICAL=F1N5F2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGN1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN1/entry", "sequence": { "sequence": "MKGQPLSRRGEGRISEGWSAKMAMAVAVAVARVWRPSRGLGRTGLPLLRLLGARGLARFHPHRWQQQQHFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEKVLKFYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDDTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDLGKGRQMPVHYGCRERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGILSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHHLQSRGWWDDEQEKAWRKQSRKKMSGPSSFISEEGYWVPASEVCLRPCTYSKCSVMEAFEQAERKLKPNPSLIFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDHFEK", "length": 501, "header": "tr|A0A3Q1MGN1-1|F1N5F2_BOVIN Computationally mapped isoform of 2-oxoisovalerate dehydrogenase subunit alpha OS=Bos taurus OX=9913 GN=BCKDHA PE=3 SV=2 CANONICAL=F1N5F2-1" }, "locus": { "chromosome": "18", "start_pos": 50560327, "end_pos": 50541472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072345.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072345.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069739.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069739.2" } ] } }, { "isoform_ac": "A0ABI0P3F3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F3/entry", "sequence": { "sequence": "MAMAVAVAVARVWRPSRGLGRTGLPLLRLLGARGLARFHPHRWQQQQHFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHGRISFYMTNYGEEGTHVGSAAALDDTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDLGKGRQMPVHYGCRERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGILSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHHLQSRGWWDDEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLIFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDHFEK", "length": 420, "header": "tr|A0ABI0P3F3-1|A0ABI0P3F3_BOVIN Computationally mapped isoform of 2-oxoisovalerate dehydrogenase subunit alpha OS=Bos taurus OX=9913 GN=BCKDHA PE=3 SV=1 CANONICAL=F1N5F2-1" }, "locus": { "chromosome": "18", "start_pos": 50560327, "end_pos": 50541535, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138793.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138793.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105117.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105117.1" } ] } }, { "isoform_ac": "F1N5F2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5F2/entry", "sequence": { "sequence": "MKGQPLSRRGEGRISEGWSAKMAMAVAVAVARVWRPSRGLGRTGLPLLRLLGARGLARFHPHRWQQQQHFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEKVLKFYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDDTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDLGKGRQMPVHYGCRERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGILSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHHLQSRGWWDDEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLIFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDHFEK", "length": 470, "header": "tr|F1N5F2-1|F1N5F2_BOVIN Isoform 1 of 2-oxoisovalerate dehydrogenase subunit alpha OS=Bos taurus OX=9913 GN=BCKDHA PE=3 SV=3 CANONICAL=F1N5F2-1" }, "locus": { "chromosome": "18", "start_pos": 50560327, "end_pos": 50541472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021342.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021342.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021342.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021342.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-70895", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "resource": "Reactome", "description": "Branched-chain amino acid catabolism" }, { "id": "R-BTA-9859138", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9859138", "resource": "Reactome", "description": "BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "pmid": "" }, { "name": "branched-chain alpha-ketoacid dehydrogenase complex", "id": "GO:0160157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160157", "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "pmid": "" }, { "name": "branched-chain 2-oxo acid dehydrogenase activity", "id": "GO:0003863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003863", "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "id": "GO:0120552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120552", "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "pmid": "" }, { "name": "branched-chain amino acid catabolic process", "id": "GO:0009083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009083", "evidence": [ { "database": "UniProtKB", "id": "F1N5F2", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13457", "name": "", "equation": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5F2-1", "P21839-1", "P11178-1" ], "evidence": [ { "id": "13457", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13457" } ] }, { "id": "84639", "name": "", "equation": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 4-methyl-2-oxopentanoate + H(+) = N(6)-[(R)-S(8)-3-methylbutanoyldihydrolipoyl]-L-lysyl-[protein] + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11178-1", "P21839-1", "F1N5F2-1" ], "evidence": [ { "id": "84639", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84639" } ] }, { "id": "84643", "name": "", "equation": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + (S)-3-methyl-2-oxopentanoate + H(+) = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11178-1", "P21839-1", "F1N5F2-1" ], "evidence": [ { "id": "84643", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84643" } ] }, { "id": "R-BTA-5693148", "name": "BCKDK phosphorylates BCKDH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11181-1", "P21839-1", "Q2KJG8-1", "F1N5F2-1", "F1N206-1" ], "evidence": [ { "id": "R-BTA-5693148", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693148" } ] }, { "id": "R-BTA-5693153", "name": "PPM1K dephosphorylates p-BCKDH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11181-1", "P21839-1", "Q2PC20-1", "F1N5F2-1", "F1N206-1" ], "evidence": [ { "id": "R-BTA-5693153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693153" } ] }, { "id": "R-BTA-9859148", "name": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11181-1", "P21839-1", "F1N5F2-1", "F1N206-1" ], "evidence": [ { "id": "R-BTA-9859148", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9859148" } ] }, { "id": "R-BTA-9859163", "name": "DBT transfers BCAA to CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11181-1", "P21839-1", "F1N5F2-1", "F1N206-1" ], "evidence": [ { "id": "R-BTA-9859163", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9859163" } ] }, { "id": "R-BTA-9859172", "name": "DLD dimer dehydrogenates dihydrolipoyl", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-BTA-9859167" ], "output_participant_list": [ "R-BTA-70017" ], "enzyme_list": [ "P11181-1", "P21839-1", "F1N5F2-1", "F1N206-1" ], "evidence": [ { "id": "R-BTA-9859172", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9859172" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-70017", "participant_name": "Lipo-K105-DBT [mitochondrial matrix]", "crossref": [ { "id": "2.3.1.168", "database": "IntEnz", "url": "" }, { "id": "P11181", "database": "UniProt", "url": "" }, { "id": "2II5", "database": "PDB", "url": "" }, { "id": "ENSBTAP00000008292", "database": "ENSEMBL", "url": "" }, { "id": "2II4", "database": "PDB", "url": "" }, { "id": "27896", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000008292", "database": "ENSEMBL", "url": "" }, { "id": "2IHW", "database": "PDB", "url": "" }, { "id": "ENSBTAG00000006320", "database": "ENSEMBL", "url": "" }, { "id": "2II3", "database": "PDB", "url": "" }, { "id": "NP_776330.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-9859167", "participant_name": "LipoH2-K105-DBT [mitochondrial matrix]", "crossref": [ { "id": "P11181", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006320", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000008292", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000008292", "database": "ENSEMBL", "url": "" }, { "id": "2.3.1.168", "database": "IntEnz", "url": "" }, { "id": "2II3", "database": "PDB", "url": "" }, { "id": "2II4", "database": "PDB", "url": "" }, { "id": "2IHW", "database": "PDB", "url": "" }, { "id": "2II5", "database": "PDB", "url": "" }, { "id": "NP_776330.1", "database": "RefSeq", "url": "" }, { "id": "27896", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1N206", "gene_name": "DLD", "activity": [ { "ec_number": "1.8.1.4", "activity": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+).", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] } ] }, { "uniprot_ac": "F1N5F2", "gene_name": "BCKDHA", "activity": [ { "ec_number": "1.2.4.4", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + (S)-3-methyl-2-oxopentanoate + H(+) = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ] }, { "ec_number": "1.2.4.4", "activity": "", "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" } ] } ] }, { "uniprot_ac": "P11178", "gene_name": "BCKDHA", "activity": [ { "ec_number": "1.2.4.4", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + (S)-3-methyl-2-oxopentanoate + H(+) = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "P11178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11178" } ] }, { "ec_number": "1.2.4.4", "activity": "", "evidence": [ { "id": "P11178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11178" } ] } ] }, { "uniprot_ac": "P11181", "gene_name": "DBT", "activity": [ { "ec_number": "2.3.1.168", "activity": "(2S)-2-methylbutanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CoA.", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.168", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] } ] }, { "uniprot_ac": "P21839", "gene_name": "BCKDHB", "activity": [ { "ec_number": "1.2.4.4", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + (S)-3-methyl-2-oxopentanoate + H(+) = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "P21839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21839" } ] }, { "ec_number": "1.2.4.4", "activity": "", "evidence": [ { "id": "P21839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21839" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F2" }, { "id": "PF00676", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00676" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dehydrogenase E1 component", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 430, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.2.4.4", "ec_name": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + (S)-3-methyl-2-oxopentanoate + H(+) = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "1.2.4.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4" }, { "id": "1.2.4.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.2.4.4" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 333, "end_pos": 335 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7B7-1", "uniprot_ac": "F1N7B7", "uniprot_id": "F1N7B7_BOVIN", "mass": { "chemical_mass": 186925.0, "monoisotopic_mass": 186925.0 }, "refseq": {}, "gene_names": [ { "name": "RIMS1", "type": "recommended", "evidence": [ { "id": "F1N7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ] } ], "protein_names": [ { "name": "Regulating synaptic membrane exocytosis 1", "type": "synonym", "evidence": [ { "id": "F1N7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIMS1", "url": "https://www.uniprot.org/uniprotkb/F1N7B7", "locus": { "chromosome": "9", "start_pos": 11696383, "end_pos": 11090031, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020238", "url": "https://www.ensembl.org/id/ENSBTAG00000020238" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020238", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020238", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04028", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04028", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04031", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04031", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06714", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06714", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJA7", "url": "https://www.orthodb.org/?gene=A0A3Q1LJA7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3X0", "url": "https://www.orthodb.org/?gene=A0A3Q1M3X0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9V3", "url": "https://www.orthodb.org/?gene=A0A3Q1M9V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBC7", "url": "https://www.orthodb.org/?gene=A0A3Q1MBC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MH95", "url": "https://www.orthodb.org/?gene=A0A3Q1MH95", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MP76", "url": "https://www.orthodb.org/?gene=A0A3Q1MP76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRF9", "url": "https://www.orthodb.org/?gene=A0A3Q1MRF9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTH8", "url": "https://www.orthodb.org/?gene=A0A3Q1MTH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVD8", "url": "https://www.orthodb.org/?gene=A0A3Q1MVD8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7B7", "url": "https://www.orthodb.org/?gene=F1N7B7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12157:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12157:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22601", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22601", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-181429", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-181429", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-181430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-181430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-210500", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210500", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-212676", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212676", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-264642", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264642", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-888590", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-888590", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJA7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3X0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3X0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9V3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9V3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9V3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBC7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH95", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH95-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP76", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP76-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVD8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVD8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7B7-1", "url": "https://www.uniprot.org/uniprotkb/F1N7B7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLETCSHWDIYSSILPARTKTQTLHHECFHSRALRFTDEILVGDLQPSLDRARSASTNCLRPDASLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQSQTRKGTASDAERVLPPCLSRRGYAAARATDQPVLRGKHPARSRSSEHPSVRTLCSMHHLAPGGSAPPSPLLTRTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRISSFTPKMQGRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1679, "header": "tr|F1N7B7-1|F1N7B7_BOVIN Isoform 1 of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=4 CANONICAL=F1N7B7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJA7/entry", "sequence": { "sequence": "MLAVFLQLRLLHTLHSGTGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTSDLQPSLDRARSASTNCLRPDASLHSPERERHSRKSERSSIQSQTRKGTASDAERTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 826, "header": "tr|A0A3Q1LJA7-1|A0A3Q1LJA7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=3 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11485750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067826.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067826.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059430.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059430.3" } ] } }, { "isoform_ac": "A0A3Q1M3X0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X0/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTSDLQPSLDRARSASTNCLRPDASLHSPERERHSRKSERSSIQSQTRKGTASDAERTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1357, "header": "tr|A0A3Q1M3X0-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=3 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087174.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087174.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064879.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064879.3" } ] } }, { "isoform_ac": "A0A3Q1M9V3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9V3/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTRTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRIRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1469, "header": "tr|A0A3Q1M9V3-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085134.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085134.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070760.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070760.2" } ] } }, { "isoform_ac": "A0A3Q1MBC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBC7/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDRTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1285, "header": "tr|A0A3Q1MBC7-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085889.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085889.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067585.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067585.2" } ] } }, { "isoform_ac": "A0A3Q1MH95-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH95/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLETCSHWDIYSDLQPSLDRARSASTNCLRPDASLHSPERERTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRISSFTPKMQGRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1535, "header": "tr|A0A3Q1MH95-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066372.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066372.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068442.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068442.2" } ] } }, { "isoform_ac": "A0A3Q1MP76-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP76/entry", "sequence": { "sequence": "TCAPGTPVSSEGWEDMRAVNPKEGSMEAWRAGAGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTSDLQPSLDRARSASTNCLRPDASLHSPERERHSRKSERSSIQSQTRKGTASDAERTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRISSFTPKMQGRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1012, "header": "tr|A0A3Q1MP76-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11481580, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067288.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067288.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073685.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073685.2" } ] } }, { "isoform_ac": "A0A3Q1MRF9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF9/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTSDLQPSLDRARSASTNCLRPDASLHSPERERTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRISSFTPKMQGRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1475, "header": "tr|A0A3Q1MRF9-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081547.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081547.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072413.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072413.2" } ] } }, { "isoform_ac": "A0A3Q1MTH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTH8/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTSDLQPSLDRARSASTNCLRPDASLHSPERERTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRISSFTPKMQGRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1509, "header": "tr|A0A3Q1MTH8-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085580.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085580.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073615.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073615.2" } ] } }, { "isoform_ac": "A0A3Q1MVD8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVD8/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTSDLQPSLDRARSASTNCLRPDASLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1365, "header": "tr|A0A3Q1MVD8-1|F1N7B7_BOVIN Computationally mapped isoform of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=2 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068382.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068382.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058967.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058967.2" } ] } }, { "isoform_ac": "F1N7B7-1", "url": "https://www.uniprot.org/uniprotkb/F1N7B7/entry", "sequence": { "sequence": "MSSAVGPRGPRPPTVPPPMPELPDLSHLTEEERNIILAVMDRQKEEEEKEEAMLKCVVRDMVKPAACKAPRNVEHQPHQPPPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSSNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSDTATGAGSEAPREKKARLQERSRSQTPLSSAAASAQDQATPGAQVDRTKGAEPAPQAGGPEQKQASSRSRSEPPRDRKKTPGLAEQNGKGAPKGERKRAPRTSAPPAEAPAEERERKERRESRRLEKGRSQDYSVVPEKREEGPVAEAEKQRKEEEYQTRYRSDPNLARYPVQPPPEEQQMRMHARVSRARHERRHSDVSLPRTEAAAGPEGRPGPRAPHAARGSPPASPRAYSAERTAEARAPGAQPLADSSPPAPRPGPGPAEVPEPLRKQSRLDPGSAVLVRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRAKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKESGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKVLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHTHGESASKKLQRSQRISDSDMSDYEVDDAIGVVPPVGYRSSTRESKPSTLTVPEQQRTTHHRSRSVSPHRGDDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHRDASRSPIDQRIRDVDSQCLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLETCSHWDIYSSILPARTKTQTLHHECFHSRALRFTDEILVGDLQPSLDRARSASTNCLRPDASLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQSQTRKGTASDAERVLPPCLSRRGYAAARATDQPVLRGKHPARSRSSEHPSVRTLCSMHHLAPGGSAPPSPLLTRTHRQASPTRSPPMDAAFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNAHTDQYRSCDNVSTRSSDSDVSDASAVSRTSSASRLSSTSFLSEQSERPRGRISSFTPKMQGRRMGTSGRAITKSTSMSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS", "length": 1679, "header": "tr|F1N7B7-1|F1N7B7_BOVIN Isoform 1 of Regulating synaptic membrane exocytosis 1 OS=Bos taurus OX=9913 GN=RIMS1 PE=4 SV=4 CANONICAL=F1N7B7-1" }, "locus": { "chromosome": "9", "start_pos": 11695379, "end_pos": 11090230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061208.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061208.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053624.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053624.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 234, "start_aa": "Thr", "end_pos": 234, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr234", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 724, "start_aa": "Thr", "end_pos": 724, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr724", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-181429", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-181429", "resource": "Reactome", "description": "Serotonin Neurotransmitter Release Cycle" }, { "id": "R-BTA-181430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-181430", "resource": "Reactome", "description": "Norepinephrine Neurotransmitter Release Cycle" }, { "id": "R-BTA-210500", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210500", "resource": "Reactome", "description": "Glutamate Neurotransmitter Release Cycle" }, { "id": "R-BTA-212676", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212676", "resource": "Reactome", "description": "Dopamine Neurotransmitter Release Cycle" }, { "id": "R-BTA-264642", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264642", "resource": "Reactome", "description": "Acetylcholine Neurotransmitter Release Cycle" }, { "id": "R-BTA-888590", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-888590", "resource": "Reactome", "description": "GABA synthesis, release, reuptake and degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "positive regulation of dendrite extension", "id": "GO:1903861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903861", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "acrosomal vesicle exocytosis", "id": "GO:0060478", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060478", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "synaptic vesicle priming", "id": "GO:0016082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016082", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "synaptic vesicle docking", "id": "GO:0016081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016081", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle exocytosis", "id": "GO:2000300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000300", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "structural constituent of presynaptic active zone", "id": "GO:0098882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098882", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "presynaptic active zone cytoplasmic component", "id": "GO:0098831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098831", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "F1N7B7", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1321, "end_pos": 1323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 492, "end_pos": 494, "annotation": "n_glycosylation_sequon" }, { "start_pos": 804, "end_pos": 806, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 736, "end_pos": 859, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" }, { "id": "PS50178", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FYVE-type", "eco_id": "ECO_0000259", "start_pos": 110, "end_pos": 170, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 599, "end_pos": 685, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7B7" }, { "id": "PS50916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RabBD", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 182, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 234, 724 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1321, "end_pos": 1323 }, { "start_pos": 492, "end_pos": 494 }, { "start_pos": 804, "end_pos": 806 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5R0-1", "uniprot_ac": "F1N5R0", "uniprot_id": "F1N5R0_BOVIN", "mass": { "chemical_mass": 87822.0, "monoisotopic_mass": 87822.0 }, "refseq": {}, "gene_names": [ { "name": "SLC6A5", "type": "recommended", "evidence": [ { "id": "F1N5R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ] } ], "protein_names": [ { "name": "Transporter", "type": "recommended", "evidence": [ { "id": "F1N5R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5R0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC6A5", "url": "https://www.uniprot.org/uniprotkb/F1N5R0", "locus": { "chromosome": "29", "start_pos": 24320076, "end_pos": 24374065, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014300", "url": "https://www.ensembl.org/id/ENSBTAG00000014300" } ] } } ], "crossref": [ { "id": "F1N5R0", "url": "https://alphafold.ebi.ac.uk/entry/F1N5R0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014300", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014300", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11499", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11499", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHT9", "url": "https://www.orthodb.org/?gene=A0A3Q1MHT9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N5R0", "url": "https://www.orthodb.org/?gene=F1N5R0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616:SF241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616:SF241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-442660", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442660", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MHT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHT9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5R0-1", "url": "https://www.uniprot.org/uniprotkb/F1N5R0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEVKDCSAPKEMNKQPANSLEAAVPSGHHDGPCAPRTSPEQELPAATAAPPPRVPRSASTGAQTFHAADARACEAERPGGAGACKLSSLRSPAASAALRDWSEAHGAQTAPPSGGAGPGNALPCKITALRGLEGDANVSVGKGTLERNNTPAVGWVNMSQSTVVLGTDGITSVLPGSVATAATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVINDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCVCFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC", "length": 802, "header": "tr|F1N5R0-1|F1N5R0_BOVIN Isoform 1 of Transporter OS=Bos taurus OX=9913 GN=SLC6A5 PE=3 SV=2 CANONICAL=F1N5R0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHT9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHT9/entry", "sequence": { "sequence": "MDCSAPKEMNKQPANSLEAAVPSGHHDGPCAPRTSPEQELPAATAAPPPRVPRSASTGAQTFHAADARACEAERPGGAGACKLSSLRSPAASAALRDWSEAHGAQTAPPSGGAGPGNALPCKITALRGLEGDANVSVGKGTLERNNTPAVGWVNMSQSTVVLGTDGITSVLPGSVATAATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVINDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCVCFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC", "length": 798, "header": "tr|A0A3Q1MHT9-1|F1N5R0_BOVIN Computationally mapped isoform of Transporter OS=Bos taurus OX=9913 GN=SLC6A5 PE=3 SV=2 CANONICAL=F1N5R0-1" }, "locus": { "chromosome": "29", "start_pos": 24373866, "end_pos": 24321080, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083984.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083984.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070792.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070792.2" } ] } }, { "isoform_ac": "F1N5R0-1", "url": "https://www.uniprot.org/uniprotkb/F1N5R0/entry", "sequence": { "sequence": "MAEVKDCSAPKEMNKQPANSLEAAVPSGHHDGPCAPRTSPEQELPAATAAPPPRVPRSASTGAQTFHAADARACEAERPGGAGACKLSSLRSPAASAALRDWSEAHGAQTAPPSGGAGPGNALPCKITALRGLEGDANVSVGKGTLERNNTPAVGWVNMSQSTVVLGTDGITSVLPGSVATAATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVINDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCVCFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC", "length": 802, "header": "tr|F1N5R0-1|F1N5R0_BOVIN Isoform 1 of Transporter OS=Bos taurus OX=9913 GN=SLC6A5 PE=3 SV=2 CANONICAL=F1N5R0-1" }, "locus": { "chromosome": "29", "start_pos": 24373482, "end_pos": 24321080, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019000.4", "url": "https://www.ensembl.org/id/ENSBTAT00000019000.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019000.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019000.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 690, "start_aa": "Thr", "end_pos": 690, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr690", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-442660", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442660", "resource": "Reactome", "description": "SLC-mediated transport of neurotransmitters" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" }, { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" }, { "name": "glycine:sodium symporter activity", "id": "GO:0015375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015375", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "synaptic transmission, glycinergic", "id": "GO:0060012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060012", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" }, { "name": "glycine import across plasma membrane", "id": "GO:1903804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903804", "evidence": [ { "database": "UniProtKB", "id": "F1N5R0", "url": "https://www.uniprot.org/uniprotkb/F1N5R0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 717, "end_pos": 719, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5R0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 802, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5R0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5R0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 690 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 149, "end_pos": 151 }, { "start_pos": 158, "end_pos": 160 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 348, "end_pos": 350 }, { "start_pos": 358, "end_pos": 360 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 717, "end_pos": 719 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4C6-1", "uniprot_ac": "F2Z4C6", "uniprot_id": "F2Z4C6_BOVIN", "mass": { "chemical_mass": 103644.0, "monoisotopic_mass": 103644.0 }, "refseq": {}, "gene_names": [ { "name": "EIF4G2", "type": "recommended", "evidence": [ { "id": "F2Z4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 4 gamma 2", "type": "recommended", "evidence": [ { "id": "F2Z4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MLW1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLW1#function" }, { "database": "UniProtKB", "id": "ARBA00037759", "url": "https://www.uniprot.org/uniprotkb/ARBA00037759#function" }, { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6#function" }, { "database": "UniProtKB", "id": "A0ABI0P1Y5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Y5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF4G2", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6", "locus": { "chromosome": "15", "start_pos": 41881439, "end_pos": 41871084, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020308", "url": "https://www.ensembl.org/id/ENSBTAG00000020308" } ] } } ], "crossref": [ { "id": "F2Z4C6", "url": "https://alphafold.ebi.ac.uk/entry/F2Z4C6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020308", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020308", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11559", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11559", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CAPLDIN", "url": "https://omabrowser.org/oma/group/CAPLDIN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLW1", "url": "https://www.orthodb.org/?gene=A0A3Q1MLW1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F2Z4C6", "url": "https://www.orthodb.org/?gene=F2Z4C6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23253:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23253:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02847", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02847", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02854", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02854", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MLW1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLW1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1Y5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4C6-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVAILRCQAAKVESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 919, "header": "tr|F2Z4C6-1|F2Z4C6_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4 gamma 2 OS=Bos taurus OX=9913 GN=EIF4G2 PE=3 SV=2 CANONICAL=F2Z4C6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLW1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLW1/entry", "sequence": { "sequence": "VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 869, "header": "tr|A0A3Q1MLW1-1|F2Z4C6_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 4 gamma 2 OS=Bos taurus OX=9913 GN=EIF4G2 PE=3 SV=2 CANONICAL=F2Z4C6-1" }, "locus": { "chromosome": "15", "start_pos": 41880673, "end_pos": 41871251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073712.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073712.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072061.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072061.2" } ] } }, { "isoform_ac": "A0ABI0P1Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1Y5/entry", "sequence": { "sequence": "VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 907, "header": "tr|A0ABI0P1Y5-1|A0ABI0P1Y5_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 4 gamma 2 OS=Bos taurus OX=9913 GN=EIF4G2 PE=3 SV=1 CANONICAL=F2Z4C6-1" }, "locus": { "chromosome": "15", "start_pos": 41880673, "end_pos": 41871251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151430.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151430.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107135.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107135.1" } ] } }, { "isoform_ac": "F2Z4C6-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6/entry", "sequence": { "sequence": "MEVAILRCQAAKVESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 919, "header": "tr|F2Z4C6-1|F2Z4C6_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4 gamma 2 OS=Bos taurus OX=9913 GN=EIF4G2 PE=3 SV=2 CANONICAL=F2Z4C6-1" }, "locus": { "chromosome": "15", "start_pos": 41880673, "end_pos": 41869620, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055320.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055320.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049614.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049614.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1169408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TP96-1", "protein_name": "Eukaryotic translation initiation factor 4 gamma 2", "gene_name": "EIF4G2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLVVSNFGTLFSFQVFRFSHPFPPHPSINIILLKILRCQAAKVESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 949 }, "evidence": [ { "id": "F2Z4C6", "url": "https://omabrowser.org/oma/group/F2Z4C6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P78344-1", "protein_name": "Eukaryotic translation initiation factor 4 gamma 2", "gene_name": "EIF4G2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 907 }, "evidence": [ { "id": "F2Z4C6", "url": "https://omabrowser.org/oma/group/F2Z4C6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62448-1", "protein_name": "Eukaryotic translation initiation factor 4 gamma 2", "gene_name": "Eif4g2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEAVVTDYLNSGNANDAVSGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD", "length": 906 }, "evidence": [ { "id": "F2Z4C6", "url": "https://omabrowser.org/oma/group/F2Z4C6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "translation factor activity, RNA binding", "id": "GO:0008135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008135", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of translational initiation", "id": "GO:0006446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006446", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "negative regulation of autophagy", "id": "GO:0010507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010507", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 4F complex", "id": "GO:0016281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016281", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C6", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 769, "end_pos": 771, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F2Z4C6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 919, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F2Z4C6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F2Z4C6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F2Z4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" }, { "id": "PS51366", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51366" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MI", "eco_id": "ECO_0000259", "start_pos": 555, "end_pos": 678, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F2Z4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C6" }, { "id": "PS51363", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51363" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "W2", "eco_id": "ECO_0000259", "start_pos": 732, "end_pos": 916, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 769, "end_pos": 771 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1E9-1", "uniprot_ac": "F1N1E9", "uniprot_id": "F1N1E9_BOVIN", "mass": { "chemical_mass": 132423.0, "monoisotopic_mass": 132423.0 }, "refseq": { "ac": "XP_024841262", "name": "leptin receptor isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841262" }, "gene_names": [ { "name": "LEPR", "type": "recommended", "evidence": [ { "id": "F1N1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ] }, { "name": "LEPR", "type": "synonym", "evidence": [ { "id": "XP_024841262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841262" } ] }, { "name": "Ob-RM", "type": "synonym", "evidence": [ { "id": "XP_024841262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841262" } ] }, { "name": "Ob-R", "type": "synonym", "evidence": [ { "id": "XP_024841262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841262" } ] } ], "protein_names": [ { "name": "Leptin receptor", "type": "recommended", "evidence": [ { "id": "F1N1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E9/entry#names_and_taxonomy" } ] }, { "name": "OB receptor", "type": "synonym", "evidence": [ { "id": "F1N1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E9/entry#names_and_taxonomy" } ] }, { "name": "leptin receptor isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024841262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841262" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LEPR", "url": "https://www.uniprot.org/uniprotkb/F1N1E9", "locus": { "chromosome": "3", "start_pos": 79741920, "end_pos": 79837754, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005910", "url": "https://www.ensembl.org/id/ENSBTAG00000005910" } ] } } ], "crossref": [ { "id": "F1N1E9", "url": "https://alphafold.ebi.ac.uk/entry/F1N1E9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005910", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005910", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "497205", "url": "https://www.ncbi.nlm.nih.gov/gene/497205", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FPPHCLF", "url": "https://omabrowser.org/oma/group/FPPHCLF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNZ1", "url": "https://www.orthodb.org/?gene=A0A3Q1MNZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1E9", "url": "https://www.orthodb.org/?gene=F1N1E9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23037:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06328", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06328", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18589", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18589", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841262", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841262", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1E9-1", "url": "https://www.uniprot.org/uniprotkb/F1N1E9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MICQKSCVALLHWEFIYVITAFNLAYPITPWKFKVSCMPSNTTYDFLFPPGISKNTSNLNGRYEAVVETKLNSSGTYLSNLSSRTTFHCCFWSEEDKNCSVYTDDIEGKAFVTTVNSLVFQQTGANWNIQCWMKEDLKLFICNIESLFKNPFKNYDLKVHLLYVLLDVLEESPLLPQKDSFQVVQCNCSVHECCECHVPVPTAKLNDTLLMYLKITSGGAVFHSPPMSAQPINVVKPDPPLGLRMEITDTGSLKISWSSPTLVPFQLQYQVQYSENSTKYIRKTDEIVSATSLLVDSVLPGSSYGAQVRCKRLDGLGIWSDWSALLTFTTQDVIYFPPKILTAVGSNISFHCIYKNEKKIVSSKKIVWWLNLAEKIPQSQYDVVDDHISKVTFPNLNATKPRGKFTYDAVYCCNEQECHHRYAELYVIDVNINISCETDGYLTKMTCRWSPNAIQSLAGSNLQLRYHRSSLYCSDVPSIHPVSEPKDCHLQRDGFYECIFQPIFLLSGYTMWIRINHTLGSLDSPPACVIPDSVVKPLPPSSVKAEITVKIGLLKISWEKPVFPENNLQFQIRYGLSGKQVQWKMFEVYDAKLKSASLPVPDLCAVYTVQVRCKRLDGLGYWSNWSTPAHTVVMDVKVPIRGPEFWRLISEDTTKKERNVTLLWKPLMKNDSLCSVRRYVVKHHTSHNGTWLEDVGNHTKLTFLWTEQAHSVMVLAINSIGASSANFNLTFSRAISKVNIVQSLSAYPLNSSCVILSWMLSPSDYNLMYFILEWKILNEDSEIKWLRIPSSVKKYYVHDYFIPIEKYQFSLYPIFTEGVGKPKIINSFAQDDEKHQHDADLYVIVPIIISSSILLLGILSVSHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTESTTFGPLLLEPETISEDISVDTSWKNKDEMVPATTDALLLTTPDLEKGSICISDQCSSAQFSEAESTDITCEDESRRQPSVKYATLLSNSKSGETEEEQGLINSSVSKCFLSNNSPPKDSSSKRSWEIETQAFFILSDQHPNIISPHLPFSEGLDELLKLEGNFPEENNNERPVYYLGVTSIKKRESDVFLTNESRVLSPFPAHCLFTDIRILQDSCSHLVENNFNLGTSGQKTFVSYMPQFQTCSTQTQKIMENKMCDLTV", "length": 1165, "header": "tr|F1N1E9-1|F1N1E9_BOVIN Isoform 1 of Leptin receptor OS=Bos taurus OX=9913 GN=LEPR PE=3 SV=3 CANONICAL=F1N1E9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MNZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNZ1/entry", "sequence": { "sequence": "MICQKSCVALLHWEFIYVITAFNLAYPITPWKFKVSCMPSNTTYDFLFPPGISKNTSNLNGRYEAVVETKLNSSGTYLSNLSSRTTFHCCFWSEEDKNCSVYTDDIEGKAFVTTVNSLVFQQTGANWNIQCWMKEDLKLFICNIESLFKNPFKNYDLKVHLLYVLLDVLEESPLLPQKDSFQVVQCNCSVHECCECHVPVPTAKLNDTLLMYLKITSGGAVFHSPPMSAQPINVVKPDPPLGLRMEITDTGSLKISWSSPTLVPFQLQYQVQYSENSTKYIRKTDEIVSATSLLVDSVLPGSSYGAQVRCKRLDGLGIWSDWSALLTFTTQDVIYFPPKILTAVGSNISFHCIYKNEKKIVSSKKIVWWLNLAEKIPQSQYDVVDDHISKVTFPNLNATKPRGKFTYDAVYCCNEQECHHRYAELYVIDVNINISCETDGYLTKMTCRWSPNAIQSLAGSNLQLRYHRSSLYCSDVPSIHPVSEPKDCHLQRDGFYECIFQPIFLLSGYTMWIRINHTLGSLDSPPACVIPDSVVKPLPPSSVKAEITVKIGLLKISWEKPVFPENNLQFQIRYGLSGKQVQWKMFEVYDAKLKSASLPVPDLCAVYTVQVRCKRLDGLGYWSNWSTPAHTVVMDVKVPIRGPEFWRLISEDTTKKERNVTLLWKPLMKNDSLCSVRRYVVKHHTSHNGTWLEDVGNHTKLTFLWTEQAHSVMVLAINSIGASSANFNLTFSRAISKVNIVQSLSAYPLNSSCVILSWMLSPSDYNLMYFILEWKILNEDSEIKWLRIPSSVKKYYVHDYFIPIEKYQFSLYPIFTEGVGKPKIINSFAQDDEKHQHDADLYVIVPIIISSSILLLGILSVSHQRMKKLFWEDVPNPKNCSWAQGLNFQKRTDIL", "length": 895, "header": "tr|A0A3Q1MNZ1-1|F1N1E9_BOVIN Computationally mapped isoform of Leptin receptor OS=Bos taurus OX=9913 GN=LEPR PE=3 SV=3 CANONICAL=F1N1E9-1" }, "locus": { "chromosome": "3", "start_pos": 79817232, "end_pos": 79746224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067031.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067031.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073045.3", "url": "https://www.ensembl.org/id/ENSBTAP00000073045.3" } ] } }, { "isoform_ac": "F1N1E9-1", "url": "https://www.uniprot.org/uniprotkb/F1N1E9/entry", "sequence": { "sequence": "MICQKSCVALLHWEFIYVITAFNLAYPITPWKFKVSCMPSNTTYDFLFPPGISKNTSNLNGRYEAVVETKLNSSGTYLSNLSSRTTFHCCFWSEEDKNCSVYTDDIEGKAFVTTVNSLVFQQTGANWNIQCWMKEDLKLFICNIESLFKNPFKNYDLKVHLLYVLLDVLEESPLLPQKDSFQVVQCNCSVHECCECHVPVPTAKLNDTLLMYLKITSGGAVFHSPPMSAQPINVVKPDPPLGLRMEITDTGSLKISWSSPTLVPFQLQYQVQYSENSTKYIRKTDEIVSATSLLVDSVLPGSSYGAQVRCKRLDGLGIWSDWSALLTFTTQDVIYFPPKILTAVGSNISFHCIYKNEKKIVSSKKIVWWLNLAEKIPQSQYDVVDDHISKVTFPNLNATKPRGKFTYDAVYCCNEQECHHRYAELYVIDVNINISCETDGYLTKMTCRWSPNAIQSLAGSNLQLRYHRSSLYCSDVPSIHPVSEPKDCHLQRDGFYECIFQPIFLLSGYTMWIRINHTLGSLDSPPACVIPDSVVKPLPPSSVKAEITVKIGLLKISWEKPVFPENNLQFQIRYGLSGKQVQWKMFEVYDAKLKSASLPVPDLCAVYTVQVRCKRLDGLGYWSNWSTPAHTVVMDVKVPIRGPEFWRLISEDTTKKERNVTLLWKPLMKNDSLCSVRRYVVKHHTSHNGTWLEDVGNHTKLTFLWTEQAHSVMVLAINSIGASSANFNLTFSRAISKVNIVQSLSAYPLNSSCVILSWMLSPSDYNLMYFILEWKILNEDSEIKWLRIPSSVKKYYVHDYFIPIEKYQFSLYPIFTEGVGKPKIINSFAQDDEKHQHDADLYVIVPIIISSSILLLGILSVSHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTESTTFGPLLLEPETISEDISVDTSWKNKDEMVPATTDALLLTTPDLEKGSICISDQCSSAQFSEAESTDITCEDESRRQPSVKYATLLSNSKSGETEEEQGLINSSVSKCFLSNNSPPKDSSSKRSWEIETQAFFILSDQHPNIISPHLPFSEGLDELLKLEGNFPEENNNERPVYYLGVTSIKKRESDVFLTNESRVLSPFPAHCLFTDIRILQDSCSHLVENNFNLGTSGQKTFVSYMPQFQTCSTQTQKIMENKMCDLTV", "length": 1165, "header": "tr|F1N1E9-1|F1N1E9_BOVIN Isoform 1 of Leptin receptor OS=Bos taurus OX=9913 GN=LEPR PE=3 SV=3 CANONICAL=F1N1E9-1" }, "locus": { "chromosome": "3", "start_pos": 79817232, "end_pos": 79741923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007764.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007764.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007764.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007764.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 29, "start_aa": "Thr", "end_pos": 29, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr29", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 627, "start_aa": "Thr", "end_pos": 627, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr627", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZR35-1", "protein_name": "Leptin receptor", "gene_name": "LEPR", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYHQIILTMSLLLGFLHVAAAHCMVHEIHPRSFTLPCLLLNETSSSPSAAGVVRSWSGWRREHGVAETNPSLLMDEESFLCCLWSNNNASCSLYSANMQARMLIPSEMSISASQERDSNWNIECWVEGKLDLLVCSLQFPKFHMRLDMKVHLLYAVSELSLGDTSTSSLKRTALAAQCNCSEYGKCECHVPSPRLNHTYVMWLKTVIGVTPLWSPLMSVKPIDIVKPEPPLNVRLEMTERGQVKICWSEPVPMPYPLRCEVNISGNSDQNGWQVVQVALNTSLDIDNMLLDSSSFAQVRCKSHCGPGFWSEWSTLYNLNVGAEVLYFPTKILTSVGSNVSFHCIYKNKTQSVASKKIVWWLNLAEEIPESQYTLVNDRVSKVTLFNLKATKPRGSFFYNALYCCHQNRECHHRYAELYVVDVNINIKCETDGYLTKMTCRWSANPNALLLGSSLQLRYHRSKIYCSNFPSTPPESEVKECHFQRNHSYECTFQPVFLLSGYTMWIELKHSLGTLESSPTCVVPADVVKPLPPSSIKAEITRNDGLLNVSWTNPVFTNDDLKFQIRYAVNREELTWELYEVLSVPTRSAVIEVQLCVEYIVQIRCRALDGLGYWSNWSRSAYAAVKDIQAPLHGPEFWRTVTEDPATGQKNVTLLWKPLMKNHSLCSVSRYVIKHQTSENTSWSEYVDNGTTCSFPWTESTHTITILAVNSIGASSVNFNLTLSQQMSTVNAVQSLIAYPVNSTCVILTWTLSPQIYVITSFIIEWRNLNKEEEMKWVQVPPNISKYYIYDHFILIEKYRFSLYPVFAAGVGKSRATDQFSKDGYASQTSSNLYMVLPIVISTSVLLLGALLVSHRRMKKLLWEDVPNPKNCSWAQGVDFQQPETFEHLFVKHPEAMSFEPLLLEPEIVLEDISVTKALEQEDTQDFLVLDSTFTKPEDSEHDSACPSSHFSGRSSLECSPSDPTSGETASQSNIKYATVISNSRSGGLYEQNKNPRCRFDGRFLAEDSLAAGARSGSSWELGNEAFLLLPDQPGSQPCKTLSLISSEGFSEPSDQDDAFTDGGSPERGLHYLGITSLVKRENDIFLTESSRLMCHFHTADLLRGVGFLQNTPPNLNAFIQSSIKAIVPYVPQFQMTAAKVQETTENSC", "length": 1148 }, "evidence": [ { "id": "F1N1E9", "url": "https://omabrowser.org/oma/group/F1N1E9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LFJ6-1", "protein_name": "Leptin receptor", "gene_name": "LEPR", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MICPKFSVALLHWEFIYVITAFDLAYPITPWKFKLSCMPPNTTYDFLLPAGISKNTSTLNGHDEAVVEMELNSSGTYLSNLSSKTTFHCCFWSEEDKNCSVHADNIAGKAFVSAVNSLVFQQTGANWNIQCWMKEDLKLFICYMESLFKNPFKNYDLKVHLLYVLLEVLEGSPLLPQKGSFQSVQCNCSARECCECHVPVSAAKLNYTLLMYLKITSGGAVFHSPLMSVQPINVVKPDPPLGLHMEITDTGNLKISWSSPTLVPFQLQYQVKYSENSTTNMRKADEIVSDTSLLVDSVLPGSSYEVQVRGKRLDGPGIWSDWSTPFTFTTQDVIYFPPKILTSVGSNISFHCIYKNENKIVSSKKIVWWMNLAEKIPQSQYDVVGDHVSKVTFPNMNATKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTNAIQSLVGSTLQLRYHRSSLYCSDVPSVHPISEPKDCQLQRDGFYECIFQPIFLLSGYTMWIRINHPLGSLDSPPTCVIPDSVVKPLPPSSVKAEITAKIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKIYEVYDTKLKSTSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSTPAYTVVTDVKVPIRGPEFWRIINEDATKKERNITLLWKPLMKNDSLCSVRSYVVKHHTSRHGTWSEDVGNHTKLTFLWTEQAHSVTVLAVNSIGASSANFNLTFSWPMSKVNIVQSLSAYPLNSSCVGLSWLLSPSDYNLMYFILEWKILNEDHEIKWLRIPSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDGEKHRNDAGLYVIVPIIISSSILLLGTLLMSHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTESVTFGPLLLEPETISEDISVDTSWKNKDEMVPPTTVSLLLTTPDLEKSSICISDQRSSAHFSEAESMEITCEDENRRQPSIKYATLLSSPKSGETEQEQELVSSLVSRCFSSSNSLPKESFSNSSWEIETQAFFILSDQHPNMISPHLSFSEGLDELMKFEGNFPKEHNDERSVYYLGVTSIKKRESDVFLTDESRVRCPFPAHCLFADIKILQESCSHLVENNFNLGTSGQKTFVSYMPQFQTCSTQTQKIMENKMYDLTV", "length": 1165 }, "evidence": [ { "id": "F1N1E9", "url": "https://omabrowser.org/oma/group/F1N1E9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P48356-1", "protein_name": "Leptin receptor", "gene_name": "Lepr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMCQKFYVVLLHWEFLYVIAALNLAYPISPWKFKLFCGPPNTTDDSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSALTDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNLQFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHRTAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVESLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAGLYVIVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPEPISEEISVDTAWKNKDEMVPAAMVSLLLTTPDPESSSICISDQCNSANFSGSQSTQVTCEDECQRQPSVKYATLVSNDKLVETDEEQGFIHSPVSNCISSNHSPLRQSFSSSSWETEAQTFFLLSDQQPTMISPQLSFSGLDELLELEGSFPEENHREKSVCYLGVTSVNRRESGVLLTGEAGILCTFPAQCLFSDIRILQERCSHFVENNLSLGTSGENFVPYMPQFQTCSTHSHKIMENKMCDLTV", "length": 1162 }, "evidence": [ { "id": "F1N1E9", "url": "https://omabrowser.org/oma/group/F1N1E9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P48357-1", "protein_name": "Leptin receptor", "gene_name": "LEPR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFASYMPQFQTCSTQTHKIMENKMCDLTV", "length": 1165 }, "evidence": [ { "id": "F1N1E9", "url": "https://omabrowser.org/oma/group/F1N1E9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62959-1", "protein_name": "Leptin receptor", "gene_name": "Lepr", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTCQKFYVVLLHWEFLYVITALNLAYPTSPWRFKLFCAPPSTTDDSFLSPAGVPNNTSSLKGASEALVEAKFNSTGIYVSELSKTIFHCCFGNEQGQNCSALTGNTEGKTLASVVKPLVFRQLGVNWDIECWMKGDLTLFICHMEPLLKNPFKNYDSKVHLLYDLPEVIDDLPLPPLKDSFQTVQCNCSVRECECHVPVPRAKVNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLRMEVTDDGNLKISWDSQTKAPFPLQYQVKYLENSTIVREAAEIVSDTSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSLPQLFTTQDVMYFPPKILTSVGSNASFCCIYKNENQTISSKQIVWWMNLAEKIPETQYNTVSDHISKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDNPSIRPTSELKNCVLQTDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITINTGLLKVSWEKPVFPENNLQFQIRYGLNGKEIQWKTHEVFDAKSKSASLPVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRIMDGDITKKERNVTLLWKPLMKNDSLCSVRRYVVKHRTAHNGTWSQDVGNQTNLTFLWAESAHTVTVLAINSIGASLVNFNLTFSWPMSKVNAVQSLSAYPLSSSCVILSWTLSPNDYSLLYLVIEWKNLNDDDGMKWLRIPSNVNKYYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDDIAKQQNDAGLYVIVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPEPVSEEISVDTAWKNKDEMVPAAMVSLLLTTPDSTRGSICISDQCNSANFSGAQSTQGTCEDECQSQPSVKYATLVSNVKTVETDEEQGAIHSSVSQCIARKHSPLRQSFSSNSWEIEAQAFFLLSDHPPNVISPQLSFSGLDELLELEGNFPEENHGEKSVYYLGVSSGNKRENDMLLTDEAGVLCPFPAHCLFSDIRILQESCSHFVENNLNLGTSGKNFVPYMPQFQSCSTHSHKIIENKMCDLTV", "length": 1162 }, "evidence": [ { "id": "F1N1E9", "url": "https://omabrowser.org/oma/group/F1N1E9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "cytokine binding", "id": "GO:0019955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019955", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "leptin receptor activity", "id": "GO:0038021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038021", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "energy homeostasis", "id": "GO:0097009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097009", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "negative regulation of autophagy", "id": "GO:0010507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010507", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "regulation of feeding behavior", "id": "GO:0060259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060259", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "T cell differentiation", "id": "GO:0030217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "regulation of transport", "id": "GO:0051049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051049", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "regulation of bone remodeling", "id": "GO:0046850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046850", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "bone growth", "id": "GO:0098868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098868", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway via STAT", "id": "GO:0097696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097696", "evidence": [ { "database": "UniProtKB", "id": "F1N1E9", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1006, "end_pos": 1008, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1016, "end_pos": 1018, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1096, "end_pos": 1098, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" }, { "start_pos": 670, "end_pos": 672, "annotation": "n_glycosylation_sequon" }, { "start_pos": 688, "end_pos": 690, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 750, "end_pos": 752, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 879, "end_pos": 881, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1E9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1165, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1E9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1E9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1E9" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 239, "end_pos": 333, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 29, 627 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1006, "end_pos": 1008 }, { "start_pos": 1016, "end_pos": 1018 }, { "start_pos": 1096, "end_pos": 1098 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 397, "end_pos": 399 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 55, "end_pos": 57 }, { "start_pos": 624, "end_pos": 626 }, { "start_pos": 659, "end_pos": 661 }, { "start_pos": 670, "end_pos": 672 }, { "start_pos": 688, "end_pos": 690 }, { "start_pos": 697, "end_pos": 699 }, { "start_pos": 728, "end_pos": 730 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 750, "end_pos": 752 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 879, "end_pos": 881 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4C4-1", "uniprot_ac": "F2Z4C4", "uniprot_id": "F2Z4C4_BOVIN", "mass": { "chemical_mass": 77529.0, "monoisotopic_mass": 77529.0 }, "refseq": { "ac": "XP_005203927", "name": "U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203927" }, "gene_names": [ { "name": "PRPF3", "type": "recommended", "evidence": [ { "id": "F2Z4C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ] }, { "name": "PRPF3", "type": "synonym", "evidence": [ { "id": "XP_005203927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203927" } ] } ], "protein_names": [ { "name": "U4/U6 small nuclear ribonucleoprotein Prp3", "type": "recommended", "evidence": [ { "id": "F2Z4C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4/entry#names_and_taxonomy" } ] }, { "name": "Pre-mRNA-splicing factor 3", "type": "synonym", "evidence": [ { "id": "F2Z4C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4/entry#names_and_taxonomy" } ] }, { "name": "U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005203927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203927" } ] } ], "function": [ { "annotation": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N7W0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7W0#function" }, { "database": "UniProtKB", "id": "ARBA00035603", "url": "https://www.uniprot.org/uniprotkb/ARBA00035603#function" }, { "database": "UniProtKB", "id": "A0A3Q1MP00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP00#function" }, { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRPF3", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4", "locus": { "chromosome": "3", "start_pos": 20311997, "end_pos": 20330621, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013946", "url": "https://www.ensembl.org/id/ENSBTAG00000013946" } ] } } ], "crossref": [ { "id": "F2Z4C4", "url": "https://alphafold.ebi.ac.uk/entry/F2Z4C4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013946", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013946", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd24162", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd24162", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510322", "url": "https://www.ncbi.nlm.nih.gov/gene/510322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NPQHRFK", "url": "https://omabrowser.org/oma/group/NPQHRFK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MP00", "url": "https://www.orthodb.org/?gene=A0A3Q1MP00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F2Z4C4", "url": "https://www.orthodb.org/?gene=F2Z4C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14212", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14212", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14212:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14212:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01480", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01480", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08572", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08572", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005203927", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203927", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7W0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7W0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7W0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4C4-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 683, "header": "tr|F2Z4C4-1|F2Z4C4_BOVIN Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 OS=Bos taurus OX=9913 GN=PRPF3 PE=4 SV=1 CANONICAL=F2Z4C4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MP00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP00/entry", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKGTDLRGREERVETHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 661, "header": "tr|A0A3Q1MP00-1|F2Z4C4_BOVIN Computationally mapped isoform of U4/U6 small nuclear ribonucleoprotein Prp3 OS=Bos taurus OX=9913 GN=PRPF3 PE=4 SV=1 CANONICAL=F2Z4C4-1" }, "locus": { "chromosome": "3", "start_pos": 20328276, "end_pos": 20312212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080551.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080551.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071368.1" } ] } }, { "isoform_ac": "A0A3Q1N7W0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7W0/entry", "sequence": { "sequence": "MCSIESCFELSSFSQRMALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 699, "header": "tr|A0A3Q1N7W0-1|F2Z4C4_BOVIN Computationally mapped isoform of U4/U6 small nuclear ribonucleoprotein Prp3 OS=Bos taurus OX=9913 GN=PRPF3 PE=4 SV=1 CANONICAL=F2Z4C4-1" }, "locus": { "chromosome": "3", "start_pos": 20328788, "end_pos": 20312212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083022.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083022.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066951.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066951.2" } ] } }, { "isoform_ac": "F2Z4C4-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4/entry", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 683, "header": "tr|F2Z4C4-1|F2Z4C4_BOVIN Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 OS=Bos taurus OX=9913 GN=PRPF3 PE=4 SV=1 CANONICAL=F2Z4C4-1" }, "locus": { "chromosome": "3", "start_pos": 20328276, "end_pos": 20312212, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018533.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018533.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018533.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018533.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BNS2-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "PRPF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGESKKN", "length": 592 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6GK69-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "Prpf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 683 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AJK4-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "PRPF3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSNSDRNRKRELKDVFGDDSEVSKESSGVKKRRIPRFEEVEDEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFINPPTPQPKISSSSQSERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTYFDPRVSITPAQRQKRTFKFHEKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTKLALITPKKELKEGEIPEIEWWDSYIIPNGLDLKGGTSSKKDEYFGITNLVEHPAQLNPPVDSDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKAKKIKKLKEDVSQGVHIAVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGEDDDESDEESVKKTNKCSLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 684 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H2W0-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "Prpf3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 683 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O43395-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "PRPF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 683 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q922U1-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp3", "gene_name": "Prpf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD", "length": 683 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VW52-1", "protein_name": "Precursor RNA processing 3, isoform A", "gene_name": "Prp3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSIITRKDGDDQKLSKKRAAASDSKSGGGSALEAPKKSRFDVPEKNGGGGEKKEEVAVPASLSSTQIKLMMAHAQREIEERKRALSNLRDKDPLLASVPSIGMPVALATQALAKKPTPEDSEKARKIAELQAQIRAKLTGNLASLIQPTAVAAAAAAAAQAQERPKPLILDDEGRTVDKSGRTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLRFHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPDDVPAMEWWDSVILTQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRRQNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDANNARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDCCVVVVEGGPKQQKKYRRLMLTRIKWEEDNAKGNDGQDVPNSCVLVWEGTSQRRHFGEIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTDQQ", "length": 598 }, "evidence": [ { "id": "F2Z4C4", "url": "https://omabrowser.org/oma/group/F2Z4C4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" }, { "name": "U4/U6 x U5 tri-snRNP complex", "id": "GO:0046540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046540", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" }, { "name": "spliceosomal tri-snRNP complex assembly", "id": "GO:0000244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000244", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F2Z4C4", "url": "https://www.uniprot.org/uniprotkb/F2Z4C4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F2Z4C4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 683, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F2Z4C4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F2Z4C4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 430, "end_pos": 432 }, { "start_pos": 550, "end_pos": 552 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2C1-1", "uniprot_ac": "F1N2C1", "uniprot_id": "F1N2C1_BOVIN", "mass": { "chemical_mass": 28664.0, "monoisotopic_mass": 28664.0 }, "refseq": {}, "gene_names": [ { "name": "C3H1orf43", "type": "recommended", "evidence": [ { "id": "F1N2C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ] } ], "protein_names": [ { "name": "Lipid transport auxiliary protein 1", "type": "recommended", "evidence": [ { "id": "F1N2C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2C1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for the formation of endoplasmic reticulum-plasma membrane junctions and functions as an accessory protein for bridge-like lipid transfer protein BLTP1, participating in lipid delivery between endoplasmic reticulum and cell membranes. Regulates the phagocytosis of Gram-negative bacteria like L. pneumophila and E. coli, as well as Gram-positive bacteria such as S. aureus.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MPI1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI1#function" }, { "database": "UniProtKB", "id": "ARBA00094356", "url": "https://www.uniprot.org/uniprotkb/ARBA00094356#function" }, { "database": "UniProtKB", "id": "A0A3Q1MRQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRQ0#function" }, { "database": "UniProtKB", "id": "A0AAA9RYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE7#function" }, { "database": "UniProtKB", "id": "A0AAA9SD77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD77#function" }, { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C3H1orf43", "url": "https://www.uniprot.org/uniprotkb/F1N2C1", "locus": { "chromosome": "3", "start_pos": 16309314, "end_pos": 16300714, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020026", "url": "https://www.ensembl.org/id/ENSBTAG00000020026" } ] } } ], "crossref": [ { "id": "F1N2C1", "url": "https://alphafold.ebi.ac.uk/entry/F1N2C1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020026", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020026", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR010876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QHAKVNM", "url": "https://omabrowser.org/oma/group/QHAKVNM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPI1", "url": "https://www.orthodb.org/?gene=A0A3Q1MPI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRQ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MRQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2C1", "url": "https://www.orthodb.org/?gene=F1N2C1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21425", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21425", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21425:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21425:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07406", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07406", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MPI1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPI1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2C1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNQNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 253, "header": "tr|F1N2C1-1|F1N2C1_BOVIN Isoform 1 of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=C3H1orf43 PE=3 SV=1 CANONICAL=F1N2C1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPI1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI1/entry", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNQNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQTINYPKGDRAWCPVFCTQLNGSHLV", "length": 245, "header": "tr|A0A3Q1MPI1-1|F1N2C1_BOVIN Computationally mapped isoform of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=C3H1orf43 PE=3 SV=1 CANONICAL=F1N2C1-1" }, "locus": { "chromosome": "3", "start_pos": 16308838, "end_pos": 16300913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072579.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072579.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071568.1" } ] } }, { "isoform_ac": "A0A3Q1MRQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRQ0/entry", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNQKIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 235, "header": "tr|A0A3Q1MRQ0-1|F1N2C1_BOVIN Computationally mapped isoform of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=C3H1orf43 PE=3 SV=2 CANONICAL=F1N2C1-1" }, "locus": { "chromosome": "3", "start_pos": 16308434, "end_pos": 16300913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070145.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070145.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057038.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057038.2" } ] } }, { "isoform_ac": "A0AAA9RYE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE7/entry", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNQNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATV", "length": 155, "header": "tr|A0AAA9RYE7-1|F1N2C1_BOVIN Computationally mapped isoform of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=C3H1orf43 PE=3 SV=1 CANONICAL=F1N2C1-1" }, "locus": { "chromosome": "3", "start_pos": 16306654, "end_pos": 16300913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104785.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104785.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076135.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076135.1" } ] } }, { "isoform_ac": "A0AAA9SD77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD77/entry", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNQNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGGQ", "length": 171, "header": "tr|A0AAA9SD77-1|F1N2C1_BOVIN Computationally mapped isoform of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=C3H1orf43 PE=3 SV=1 CANONICAL=F1N2C1-1" }, "locus": { "chromosome": "3", "start_pos": 16308247, "end_pos": 16300913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108814.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108814.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081808.1" } ] } }, { "isoform_ac": "F1N2C1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1/entry", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSKVQDIKYEPQLLADDDARLLQLETQGNQNCYNYLYRMKALDAIRASEIPFHAEGRHPHSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGLSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 253, "header": "tr|F1N2C1-1|F1N2C1_BOVIN Isoform 1 of Lipid transport auxiliary protein 1 OS=Bos taurus OX=9913 GN=C3H1orf43 PE=3 SV=1 CANONICAL=F1N2C1-1" }, "locus": { "chromosome": "3", "start_pos": 16308434, "end_pos": 16300913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026674.3", "url": "https://www.ensembl.org/id/ENSBTAT00000026674.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000026674.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VV85-1", "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "C1orf43", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRASEIPFHAEGRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQSEYLRYQEALSELATVVKARSGSSQRQHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 219 }, "evidence": [ { "id": "F1N2C1", "url": "https://omabrowser.org/oma/group/F1N2C1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A1ZAM0-1", "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "Dmel\\CG6665", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDGHLRLHKVGDYAAPSLQEKASKAGGNMEQLSGVMIIIIISGGVLTCLMLFIFAKRQIMRFQLRGRRGPHVPVGNDAKKALRREIERRLDCIQKITQEPKLLWDDGDKYIVQPEQEAPLPPYYYRMKAVDDVKLLESEIARADGSSRHAPESLRAFLLTTLSVTLNGAGQRMIHQYCDMYEHARHDPNEFGKDEYEAYHHLLLKLMEASKQLKNYNSRKASPARTPRKQTKMHSLLDPARLRPPTTLENVQPSSELKTGQHAKVNLTLGLQGGGGGGGDGPAELATNPLHLQAPSDRDLIIRNRIKTPTLDDIIVEADHHQSSDGGVMEDNEIKSISSMQFQRNSSNV", "length": 349 }, "evidence": [ { "id": "F1N2C1", "url": "https://omabrowser.org/oma/group/F1N2C1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "G3HBZ9-1", "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "C1H1orf43", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDTRLLQLETQGNQTGCYNYLYRMKALDAIRASEIPFHAEGRHPCSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQSEYLRYQEALSELATVVKARIGSSQRQHQSAAKDLTQSPEMSPTTIQVTYLPSSQKSKRPKHFLELKSFKDNYNTLESTL", "length": 254 }, "evidence": [ { "id": "F1N2C1", "url": "https://omabrowser.org/oma/group/F1N2C1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5XII8-1", "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "Ltap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDTRLLQLETQGSQKIPFHAEGRHPCSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQSEYLRYQEALSELATVVKARIGSSQRQHQSAAKDLTQSPEMSPTTIQVTYLPSSQKSKRPKHFLELKSFKDNYNTLESTL", "length": 235 }, "evidence": [ { "id": "F1N2C1", "url": "https://omabrowser.org/oma/group/F1N2C1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R092-3", "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "Ltap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDTRLLQLETQGNQSCYNYLYRMKALDAIRASEIPFHAEGRHPCSLMGKNFRSYLLDLRNTSTPFKGVGKALIDTLLDGYETARYGTGVFGQSEYLRYQEALSELATVVKARIGSSQRQHQSAAKDLTQSPEMSPTTIQVTYLPSSQKSKRPKHFLELKSFKDNYNTLESTL", "length": 253 }, "evidence": [ { "id": "F1N2C1", "url": "https://omabrowser.org/oma/group/F1N2C1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BWL3-1", "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "LTAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRTSEIPFHSEGRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQNEYLRYQEALSELATAVKARIGSSQRHHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL", "length": 253 }, "evidence": [ { "id": "F1N2C1", "url": "https://omabrowser.org/oma/group/F1N2C1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ], "pmid": "" }, { "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "evidence": [ { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "F1N2C1", "url": "https://www.uniprot.org/uniprotkb/F1N2C1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2C1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 253, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2C1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2C1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N222-1", "uniprot_ac": "F1N222", "uniprot_id": "F1N222_BOVIN", "mass": { "chemical_mass": 79669.0, "monoisotopic_mass": 79669.0 }, "refseq": {}, "gene_names": [ { "name": "SDAD1", "type": "recommended", "evidence": [ { "id": "F1N222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N222" } ] } ], "protein_names": [ { "name": "Protein SDA1", "type": "recommended", "evidence": [ { "id": "F1N222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N222/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for 60S pre-ribosomal subunits export to the cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T017", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T017#function" }, { "database": "UniProtKB", "id": "ARBA00003823", "url": "https://www.uniprot.org/uniprotkb/ARBA00003823#function" }, { "database": "UniProtKB", "id": "RU365057", "url": "https://www.uniprot.org/uniprotkb/RU365057#function" }, { "database": "UniProtKB", "id": "A0A3Q1MQK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQK0#function" }, { "database": "UniProtKB", "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDAD1", "url": "https://www.uniprot.org/uniprotkb/F1N222", "locus": { "chromosome": "6", "start_pos": 90809716, "end_pos": 90841174, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007639", "url": "https://www.ensembl.org/id/ENSBTAG00000007639" } ] } } ], "crossref": [ { "id": "F1N222", "url": "https://alphafold.ebi.ac.uk/entry/F1N222", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007639", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007639", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027312", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027312", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AMYKTYK", "url": "https://omabrowser.org/oma/group/AMYKTYK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12730", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12730", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12730:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12730:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05285", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05285", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08158", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08158", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21638", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21638", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MQK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T017", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T017", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T017-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T017-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N222-1", "url": "https://www.uniprot.org/uniprotkb/F1N222-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNIVLQNFMYTMLRDSNATAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALTFFLGKDEEEKQDSDSESEDEGPTARDLLVQYATGKKSSKNKKLEKAMKVLTKHKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESSKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNAGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIQLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEILEVENEEENAEGDEDGWESASLSDEADSDGEWVDVHHSSDEEQKEISEKLNSMPLEERKAKAAAVSTSRVLSQEDFQKIRMAQMRKELDAAPGKAQKRKYIEIDSDEERRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKMNPFSSSTNKEKKKQKNFMMMRYSHNVRSKNKRSFREKQLALRDALLKKRKRMK", "length": 687, "header": "tr|F1N222-1|F1N222_BOVIN Isoform 1 of Protein SDA1 OS=Bos taurus OX=9913 GN=SDAD1 PE=3 SV=3 CANONICAL=F1N222-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQK0/entry", "sequence": { "sequence": "MSSRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNIVLQNFMYTMLRDSNATAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALTFFLGKDEEEKQDSDSESEDEGPTARDLLVQYLEKAMKVLTTMGPQYTSLIIFFFPDFAEKLLKQLESSKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQRGKTSACCVPFVIIQSLLMTVANNFVTDKNAGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIQLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEILEVENEEENAEGDEDGWESASLSDEADSDGEWVDVHHSSDEEQKEISEKLNSMPLEERKAKAAAVSTSRVLSQEDFQKIRMAQMRKELDAAPGKAQKRKYIEIDSDEERRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKMNPFSSSTNKEKKKQKNFMMMRYSHNVRSKNKRSFREKQVSST", "length": 648, "header": "tr|A0A3Q1MQK0-1|F1N222_BOVIN Computationally mapped isoform of Protein SDA1 OS=Bos taurus OX=9913 GN=SDAD1 PE=3 SV=2 CANONICAL=F1N222-1" }, "locus": { "chromosome": "6", "start_pos": 90841097, "end_pos": 90814823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071321.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071321.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072038.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072038.2" } ] } }, { "isoform_ac": "A0AAA9T017-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T017/entry", "sequence": { "sequence": "MSSRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTLYTHIVTDIKNINAKHKNNKVNIVLQNFMYTMLRDSNATAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALTFFLGKDEEEKQDSDSESEDEGPTARDLLVQYATGKKSSKNKKLEKAMKVLTKHKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESSKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNAGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIQLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEILEVENEEENAEGDEDGWESASLSDEADSDGEWVDVHHSSDEEQKEISEKLNSMPLEERKAKAAAVSTSRVLSQEDFQKIRMAQMRKELDAAPGKAQKRKYIEIDSDEERRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKMNPFSSSTNKEKKKQKNFMMMRYSHNVRSKNKRSFREKQLALRDALLKKRKRMK", "length": 650, "header": "tr|A0AAA9T017-1|F1N222_BOVIN Computationally mapped isoform of Protein SDA1 OS=Bos taurus OX=9913 GN=SDAD1 PE=3 SV=1 CANONICAL=F1N222-1" }, "locus": { "chromosome": "6", "start_pos": 90841097, "end_pos": 90810564, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122811.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122811.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092070.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092070.1" } ] } }, { "isoform_ac": "F1N222-1", "url": "https://www.uniprot.org/uniprotkb/F1N222/entry", "sequence": { "sequence": "MSSRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNIVLQNFMYTMLRDSNATAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALTFFLGKDEEEKQDSDSESEDEGPTARDLLVQYATGKKSSKNKKLEKAMKVLTKHKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESSKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNAGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIQLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEILEVENEEENAEGDEDGWESASLSDEADSDGEWVDVHHSSDEEQKEISEKLNSMPLEERKAKAAAVSTSRVLSQEDFQKIRMAQMRKELDAAPGKAQKRKYIEIDSDEERRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKMNPFSSSTNKEKKKQKNFMMMRYSHNVRSKNKRSFREKQLALRDALLKKRKRMK", "length": 687, "header": "tr|F1N222-1|F1N222_BOVIN Isoform 1 of Protein SDA1 OS=Bos taurus OX=9913 GN=SDAD1 PE=3 SV=3 CANONICAL=F1N222-1" }, "locus": { "chromosome": "6", "start_pos": 90841097, "end_pos": 90810564, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007240.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007240.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007240.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007240.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 242, "start_aa": "Thr", "end_pos": 242, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr242", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XLN0-1", "protein_name": "Protein SDA1", "gene_name": "SDAD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGRQGNKLPSNLPQLQNLIKRDPTSYTEEFLQQYHHYQSHVEIFTFQPDKPNKELAELVMFLAQVGRALLRENTRAAVGPLSGCGVGVWLRFTELCWHSQIAIVAHCYPEQMANFPQQLKELLSYHHTVLDADLRMTFCKALMLLRNKNLINPTSLLELFFQLLRCHDKLLRKTLYTHIVTDIKNVNAKHKNNRINTTLQNFMYTMLRDSNPTAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKVLVAGLKFFLGKDEDENQESDSDSEDDGPTARDLMVRYATSKKTSKRKKKLEKAMKVLKKHKKKSKPEVFNFSAIHLIHDPQDFAEKLLKQLENCKERFEVKMMLMDLISRLVGIHELFLFNFYPFIQRFLQPHQREVTKILLFAAHASHQLVPPEIIQSVLMTIANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEDLLHDLAHYKTHKNKNVMMSARTLIHLFRSLNPEMLQKKYRGKPTEASVEARIHEYGELDAKDYIPGAEVLEVEDQEKEGGNQEEDGWESASMSEEDDGEDGEWIDVHHSSDEEQQEVAEKIKSMPVEERKAKAAAVSTSRLLTQEDFHRIRLAQLSREINSAPGKAAKRKNIEIDDEEESRGELLSLRDIEHLHKKPKSDKETRLATAMAGKTDRKEFVKKKKRLNPFASSTNKEKKKQKNFMMMRYSHNVRTKNKRSFREKQLALRDALLRKKKQLLK", "length": 730 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RYU6-1", "protein_name": "Protein SDA1", "gene_name": "SDAD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQIGHCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNIVLQNFMYTMLRDSNATAAKISLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALTFFLGKDEEEKQGSDSESEDDTPTARDLLVQYATGKKSSKNKKKLEKAMKVLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESSKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIQLFRTLNPQMLQKKFRGKPTEASLEARVQEYGELDAKDYIPGAEILEVEKEENAEEDGDGWESTSLSDEADSDGEWVDVHHSSDEEQKEISEKLNSMPLEERKAKAAAVSTSRVLSQEDFQKIRMAQMRKELDAAPGKAQKRKYVEIDSDEEPRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKMNPFSSSTNKEKKKQKNFMMMRYSHNVRSKNKRSFREKQLALRDALLKKRKRMK", "length": 687 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3ID18-1", "protein_name": "Protein SDA1", "gene_name": "Sdad1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNMEIFKLQPNKPSKDLAELVMFMAQIGHCYPEHLSNFPQELKELLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKITKILVAALTFFLGKDEGEKQDSDSESEDEGPTARDLLVQYATGKKGSKNKKKLEKAMKVLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESCKERFEVKMMFMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARIQEYGELDAKDYIPGAEVLEIEKEEDTENDEDGWESASLSPEEEEDGEWVDVHHSSDEEQQEIAKKLDSMPMEERKAKAAAISTSRVLTQDDFQKIRMAQMKKEMDAAPGKAQKRKYIEIDSDEESRGELLSLRDIERLHKKPKSDKETRLATAMAGRTDRKEFVRKKTKINPFSSSTNKEKKKQKNFMMMRYSQNVRSKNKRSFREKQLALRDALLKKRKRMK", "length": 687 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53313-1", "protein_name": "Protein SDA1", "gene_name": "SDA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGRRSRAAMLPTNIILLQNLVKRDPESYQEEFLQQYAHYESLRDIFMLNGLAGGDSAAATNGLDVGNGSSTMAGTNGTTMSTSTSQLIELVGFVSQVCSCFPRETANFPSELKQLLLEHHKSLPFELKEKILSCLTMLRNKDVITAEELIQSLFPLLVAYSSHGNSLGVNSHAKELRKIIYTNLISLLKSCNTNGKNQKLNKSTQAVCFNLLDQPDSQGIWATKLTRELWRRGIWDDSRTVEIMTQAALHQDVKIVMSGVMFFLDADREREENFEENSEDEDGFDLDALRHKMQVNKKTGRRGKKLENAIKTVKKKKKNGPGAPQGYLNFSAIHLLRDPQGFAEKLFKEHLSGKTKNKFDMEQKISLMQLLSRLIGTHKLIVLGIYTFFLKYLTPKQRDVTRIMSACAQACHDLVPPEVINVMVRKIADEFVSDGVANEVAAAGINTIREICSRAPLAIDEILLQDLVEYKGSKAKGVNMAAKSLIALYRDVAPEMLKKKDRGKNAAMEVQEAKKGGKDSKRPQFGADNSVQGIAGIELLAKWKKEHGEESENEDADANWEVDVDSEEDDVDGEWVTMDSDKEYDVDMEDSDDEKDNAKGKESDSDLELSDDDDEKEVKDEQEDADIDPEAAFREIASTRILTPADFAKLQELRNEESVAKIMGIHKQDKREELVDASTLTGPIKYKQSREERLQKVLEGREGRDKFGSRRGKRDNMRSTTNREKERRKNFVMSIHKRSVRGKQKMSLRDKQKVLRAHITKQKKKGY", "length": 767 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55DE2-1", "protein_name": "Protein SDA1 homolog", "gene_name": "sdad1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGTRILDLLQLQNLTKRDPSAYKEEFLLQYQHYLTQLQIFQLKPTKEFKHFSQLVSYLSHVCVCYPKELSEFPKQISDLLENNCNNLEPELRRILAKSLILMRNRNLLPQIQMLSLFFKLFRVHDKPLRSLLYSHIVADIKNTNLKQKNQKLNRTLQNFMFTMMNDDSEIASKMSLKVMIELFRKKIWHDTKTVNVISNGVFSKNSKILITTLNFFLHIDNPDKPDEEEEDEAVKEKRAKDNFRKKSLAHRVGKKTKGRITRLAKSKVDLKKAKQEEDNKLQPNFPAIELIHDPQGYCDKLFNVLVKTTEKFETRIMIMNFISRLIYVHKLMVYNFYPFLQKYLQPHQKNITYLLAVLAQSCHELVDPDVLKPLVMTIAKYFVNDGCGSDVIAIGLNTIRSICSRCPLAIDTVLLADLIQYREKKEKGVAMASKSLLQFFKDNYPSMLPKKERGKNKTDIGLLAFGHQKVSQGIDGLDLLMDEELNARLDAIEAGEEFESDDDSDSDSDDEGWEDVNTTTADDDNNSEWVSDDDDEEGEEDEEVEDEEDEEEVDEEELEDDEEGDWESGEEIEGDDDDDEEWEEVEEEVEEEEEEEIKPTKKKSQQKEKVEVLRTDDIKVLTDEELIRIRKLRILKEARENNKQYEDMDQDDDENGENVHGLIRPEDLQGAHKKKKEEKLERIARAKEGRDGGYGSKASRRDKTGKSTTNEYKAKVTKPFVLTLKTKKVRGKSLKSFRDKQIGQREHSARQKRGRH", "length": 756 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XIQ5-1", "protein_name": "Protein SDA1 homolog", "gene_name": "Sdad1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNMEIFKLQPNKPSKELAELVMFMAQIGHCYPEHLSEFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSDLLELFFELLRCRDKLLRKTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKITKILVAALTFFLGKDEEEKQDSDSESEDDGPTARDLLVQYATGKKGSKNKKKLEKAMKVLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESCKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLLTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARIQEYGELDAKDYIPGAEVLELEKEENTENDEDGWESASLSEEEEDGEWVDVHHSSDEEQQAVAKKLDSMPMEERKAKAAAVSTSRVLTQDDFQKIRMAQMKKEMDAAPGKAQKRKYLDMDSDEESRGELLSLRDIERLHKKPKSDKETRLATAMAGRTDRKEFVRKKTKINPFSSSTNKEKKKQKNFMMMRYSQNVRSKTSRSFREKQLALRDALLKKRKRMK", "length": 686 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7KKH3-1", "protein_name": "Protein SDA1 homolog", "gene_name": "Mys45A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVRPNNNQLPENLPQLQNLIKRDPESYSDEFHIQYQHFLSLLEVFALNPSEENKSLDDIVMFVAQVAQCYPAVCEEFPKRLSDLLKNYATVLDPAMRNCFVKALILLRNKNLVPALDILELFFQLLRCPDKNLRTFLQTHIVTDIKNMNAKHKDMKLNSSLQAFMYSMLKDANPKAAKMSADIMIELYKKNIWNDSKTVNVIATVGCFSKVTKVLVTSLKFFLGHDEEDEEEDTDSENEVDLKGALMANRVNKKTKKRTKQLAQIKKQAVKAQKKKKNAPAFNFSGIHLVHNPQGMAEGLFKQLQATNERFEVKLMHLDVISRLIGIHDLFLFGFYPYITRFLQPHQRQVTRVLQFAAQASHELVPGDIIEPILKTIANNFITERNSSDVMAIGLNATREICMRCPLAMGEDLLQDLAMYKTYKEKSVMMAARSLITLYREQLPALLHKKDRGRQTEAQAERKVRAYGEREVHDTVLGAEALLKDSKTIDIESEDDTDSNDGEWVNVAHSDGEGGGADDDEEDEDEDEDDDDEDEDEENSNDEENEDEDNSDEGVESGEESAKAKKEKKDMRILNQKEAAQELALTRIFTDEDFKRINAANLKKTVTSARKRPLEQDRAEFVKLNSIEMIYKKRKHDKESRLETVQAGRQDRERFGWKDGRVNEHCSKTNREKRKTKNFGMLRHKARSKVKKSFKDKQQALRKHLLHQKKMK", "length": 712 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q80UZ2-1", "protein_name": "Protein SDA1 homolog", "gene_name": "Sdad1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRNNNKLPSNLPQLQNLIKRDPPAYVEEFLQQYNHYKSNMEIFKLQPNKPSKELAELVMFMAQIGQCYPEHLSNFPQELKDLLSYNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELLRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKITKILVAALTFFLGKDEEEKQDSDSESEDDGPTARDLLVQYATGKKGSKNKKKLEKAMKVLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLESCKERFEVKMMLMNLISRLVGIHELFLFNFYPFVQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLVTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARIQEYGELDAKDYIPGAEVLELEKGENTEDDEDGWESASLSEEEEEDGEWVDVHHSSDEEQQAIATKLDSMPMEERKAKAAAISTSRVLTQDDFQKIRMAQMKKEMDAAPGKAQKRKYLEIDSDEESRGELLSLRDIERLHKKPKSDKETRLATAMAGRTDRKEFVRKKTKINPFSSSTNKEKKKQKNFMMMRYSQNVRSKSARSFRDKQLALRDALLKKRKRMK", "length": 687 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVU7-1", "protein_name": "Protein SDA1 homolog", "gene_name": "SDAD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEYLSNFPQEVKDLLSCNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELFRCHDKLLRKTLYTHIVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKVTKILVAALTFFLGKDEDEKQDSDSESEDDGPTARDLLVQYATGKKSSKNKKKLEKAMKVLKKQKKKKKPEVFNFSAIHLIHDPQDFAEKLLKQLECCKERFEVKMMLMNLISRLVGIHELFLFNFYPFLQRFLQPHQREVTKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQYKTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEVLEVEKEENAENDEDGWESTSLSEEEDADGEWIDVQHSSDEEQQEISKKLNSMPMEERKAKAAAISTSRVLTQEDFQKIRMAQMRKELDAAPGKSQKRKYIEIDSDEEPRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRKKTKTNPFSSSTNKEKKKQKNFMMMRYSQNVRSKNKRSFREKQLALRDALLKKRKRMK", "length": 687 }, "evidence": [ { "id": "F1N222", "url": "https://omabrowser.org/oma/group/F1N222/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "ribosomal large subunit export from nucleus", "id": "GO:0000055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000055", "evidence": [ { "database": "UniProtKB", "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222" } ], "pmid": "" }, { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N222", "url": "https://www.uniprot.org/uniprotkb/F1N222" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N222-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 687, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N222-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N222" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N222" }, { "id": "PF21638", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21638" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SDA1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 638, "end_pos": 684, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N222" }, { "id": "PF08158", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SDA1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 62, "end_pos": 423, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N222" }, { "id": "PF05285", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05285" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SDA1 middle", "eco_id": "ECO_0000259", "start_pos": 484, "end_pos": 620, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 242 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4S5-1", "uniprot_ac": "F1N4S5", "uniprot_id": "F1N4S5_BOVIN", "mass": { "chemical_mass": 24171.0, "monoisotopic_mass": 24171.0 }, "refseq": { "ac": "NP_001069859", "name": "peptidyl-prolyl cis-trans isomerase FKBP14 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069859" }, "gene_names": [ { "name": "FKBP14", "type": "recommended", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] }, { "name": "FKBP14", "type": "synonym", "evidence": [ { "id": "NP_001069859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069859" } ] } ], "protein_names": [ { "name": "peptidylprolyl isomerase", "type": "recommended", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5/entry#names_and_taxonomy" } ] }, { "name": "5.2.1.8", "type": "synonym", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5/entry#names_and_taxonomy" } ] }, { "name": "FK506 binding protein 14, 22 kDa", "type": "synonym", "evidence": [ { "id": "NP_001069859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069859" } ] }, { "name": "peptidyl-prolyl cis-trans isomerase FKBP14 precursor", "type": "synonym", "evidence": [ { "id": "NP_001069859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069859" } ] } ], "function": [ { "annotation": "PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWI1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI1#function" }, { "database": "UniProtKB", "id": "ARBA00059888", "url": "https://www.uniprot.org/uniprotkb/ARBA00059888#function" }, { "database": "UniProtKB", "id": "F1N4S5", "url": "https://www.uniprot.org/uniprotkb/F1N4S5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4S5", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FKBP14", "url": "https://www.uniprot.org/uniprotkb/F1N4S5", "locus": { "chromosome": "4", "start_pos": 66340716, "end_pos": 66328677, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007870", "url": "https://www.ensembl.org/id/ENSBTAG00000007870" } ] } } ], "crossref": [ { "id": "F1N4S5", "url": "https://alphafold.ebi.ac.uk/entry/F1N4S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007870", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007870", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615718", "url": "https://www.ncbi.nlm.nih.gov/gene/615718", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615718", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615718", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQMCVGE", "url": "https://omabrowser.org/oma/group/KQMCVGE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWI1", "url": "https://www.orthodb.org/?gene=A0A3Q1LWI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTP0", "url": "https://www.orthodb.org/?gene=A0A3Q1MTP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4S5", "url": "https://www.orthodb.org/?gene=F1N4S5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46222:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46222:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00254", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00254", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069859", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16237", "url": "https://www.rhea-db.org/rhea/16237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWI1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWI1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S5", "url": "https://www.uniprot.org/uniprotkb/F1N4S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S5-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLFLWNAVLTLLVTCLSGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLTIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKNEVKVYLKKEFEKHGAVVNESHHDVLVEDIFDKEDEDKDGFISAREFTYKHDEL", "length": 211, "header": "tr|F1N4S5-1|F1N4S5_BOVIN Isoform 1 of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP14 PE=4 SV=2 CANONICAL=F1N4S5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWI1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI1/entry", "sequence": { "sequence": "MRLFLWNAVLTLLVTCLSGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLTIPPALGYGKEGKESHETNPANMYLNTSFVVFEYHVCMPPFGKIAVFFMTSSACPLPRSGMVRFSTQCKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKNEVKVYLKKEFEKHGAVVNESHHDVLVEDIFDKEDEDKDGFISAREFTYKHDEL", "length": 265, "header": "tr|A0A3Q1LWI1-1|A0A3Q1LWI1_BOVIN Computationally mapped isoform of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP14 PE=4 SV=1 CANONICAL=F1N4S5-1" }, "locus": { "chromosome": "4", "start_pos": 66338592, "end_pos": 66328856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068827.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068827.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061783.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061783.1" } ] } }, { "isoform_ac": "A0A3Q1MTP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTP0/entry", "sequence": { "sequence": "MRLFLWNAVLTLLVTCLSGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLTIPPALGYGKEGKVFEYHVCMPPFGKIAVFFMTSSACPLPRSGMVRFSTQCKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKNEEIIVLEKSILRLPILLLFFPLMQ", "length": 219, "header": "tr|A0A3Q1MTP0-1|F1N4S5_BOVIN Computationally mapped isoform of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP14 PE=4 SV=2 CANONICAL=F1N4S5-1" }, "locus": { "chromosome": "4", "start_pos": 66335652, "end_pos": 66328856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082931.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082931.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058057.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058057.2" } ] } }, { "isoform_ac": "F1N4S5-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S5/entry", "sequence": { "sequence": "MRLFLWNAVLTLLVTCLSGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLTIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKNEVKVYLKKEFEKHGAVVNESHHDVLVEDIFDKEDEDKDGFISAREFTYKHDEL", "length": 211, "header": "tr|F1N4S5-1|F1N4S5_BOVIN Isoform 1 of peptidylprolyl isomerase OS=Bos taurus OX=9913 GN=FKBP14 PE=4 SV=2 CANONICAL=F1N4S5-1" }, "locus": { "chromosome": "4", "start_pos": 66338592, "end_pos": 66328856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033684.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033684.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033594.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033594.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:615718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615718", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7KCM6-1", "protein_name": "peptidylprolyl isomerase", "gene_name": "Fkbp14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRFFLWNAILTLWVMAVSSALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTKSELIDGVGVVIEVIREGFPGAWQGSSHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKHEVKVYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYVHDEL", "length": 238 }, "evidence": [ { "id": "F1N4S5", "url": "https://omabrowser.org/oma/group/F1N4S5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C487-1", "protein_name": "peptidylprolyl isomerase", "gene_name": "FKBP14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVLRAVLLGALLGCAAAALIPAADVKVEVLQKPFLCHRRTKWGDMMLVHYEGFLQSDGSMFHSTHKHNNGQPMWFTLGIREAIKGWDKGLKDMCVGEKRKLTIPPALAYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKQEVKIYLKKEFEKHGAVVNDTQHDALVEDIFDKEDEDSDGFISAREFTYKHDEL", "length": 210 }, "evidence": [ { "id": "F1N4S5", "url": "https://omabrowser.org/oma/group/F1N4S5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P59024-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP14", "gene_name": "Fkbp14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFFLWNAILALWVTVLSGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPVWFTLGILEVLKGWDQGLKGMCVGEKRKLTVPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLQKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYVHDEL", "length": 211 }, "evidence": [ { "id": "F1N4S5", "url": "https://omabrowser.org/oma/group/F1N4S5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NWM8-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP14", "gene_name": "FKBP14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYKHDEL", "length": 211 }, "evidence": [ { "id": "F1N4S5", "url": "https://omabrowser.org/oma/group/F1N4S5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "F1N4S5", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N4S5", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N4S5", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4A4-1", "P18203-1", "Q5BIN5-1", "A6QPY8-1", "F1N4S5-1", "F1N6W2-1", "G3X8B1-1", "A0A3Q1LI03-1", "A0AAA9TG77-1", "F1MNW5-1", "E1B9G4-1", "G3MXV0-1", "Q2KJC8-1", "A0AAF6YJC8-1", "A0AAF6YJR2-1", "P26882-1", "F6RD06-1", "Q32PA9-1", "Q0P5D0-1", "Q2KJ44-1", "Q2HJ89-1", "Q08E11-1", "Q9TRY0-1", "A0A3Q1LK42-1", "A4FV72-1", "P26884-1", "P30404-1", "P62935-1", "P68107-1", "Q29RZ2-1", "P80311-1", "A0AAA9RV00-1", "F1MU79-1", "A0A3Q1LJJ1-1", "Q5E992-1", "Q2YDL5-1", "A0AAA9U018-1", "A0ABI0NKM5-1", "A0ABI0NMT7-1", "A0A3Q1LSB7-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LI03", "gene_name": "FKBP11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI03" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI03" } ] } ] }, { "uniprot_ac": "A0A3Q1LJJ1", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ1" } ] } ] }, { "uniprot_ac": "A0A3Q1LK42", "gene_name": "FKBP8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] } ] }, { "uniprot_ac": "A0A3Q1LSB7", "gene_name": "LOC786614", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSB7" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSB7" } ] } ] }, { "uniprot_ac": "A0A3Q1M4A4", "gene_name": "LOC112445968", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1M4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4A4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1M4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4A4" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9TG77", "gene_name": "FKBP15", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9TG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG77" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9TG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG77" } ] } ] }, { "uniprot_ac": "A0AAA9U018", "gene_name": "AIP", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9U018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U018" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9U018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U018" } ] } ] }, { "uniprot_ac": "A0AAF6YJC8", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAF6YJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAF6YJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC8" } ] } ] }, { "uniprot_ac": "A0AAF6YJR2", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] } ] }, { "uniprot_ac": "A0ABI0NKM5", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0ABI0NKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKM5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0ABI0NKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKM5" } ] } ] }, { "uniprot_ac": "A0ABI0NMT7", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0ABI0NMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT7" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0ABI0NMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT7" } ] } ] }, { "uniprot_ac": "A4FV72", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A4FV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV72" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A4FV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV72" } ] } ] }, { "uniprot_ac": "A6QPY8", "gene_name": "PIN4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A6QPY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPY8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A6QPY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPY8" } ] } ] }, { "uniprot_ac": "E1B9G4", "gene_name": "PPIL3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] } ] }, { "uniprot_ac": "F1MNW5", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1MNW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1MNW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW5" } ] } ] }, { "uniprot_ac": "F1MU79", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1MU79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU79" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1MU79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU79" } ] } ] }, { "uniprot_ac": "F1N4S5", "gene_name": "FKBP14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] } ] }, { "uniprot_ac": "F1N6W2", "gene_name": "PPIL4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] } ] }, { "uniprot_ac": "F6RD06", "gene_name": "FKBP7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F6RD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD06" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F6RD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD06" } ] } ] }, { "uniprot_ac": "G3MXV0", "gene_name": "FKBP5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3MXV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXV0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3MXV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXV0" } ] } ] }, { "uniprot_ac": "G3X8B1", "gene_name": "LOC613401", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3X8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X8B1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3X8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X8B1" } ] } ] }, { "uniprot_ac": "P18203", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P18203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18203" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P18203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18203" } ] } ] }, { "uniprot_ac": "P26882", "gene_name": "PPID", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26882" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26882" } ] } ] }, { "uniprot_ac": "P26884", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26884" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26884" } ] } ] }, { "uniprot_ac": "P30404", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30404" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30404" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68107", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68107" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P68107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68107" } ] } ] }, { "uniprot_ac": "P80311", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] } ] }, { "uniprot_ac": "Q08E11", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q08E11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E11" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q08E11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E11" } ] } ] }, { "uniprot_ac": "Q0P5D0", "gene_name": "PPIH", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q0P5D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5D0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q0P5D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5D0" } ] } ] }, { "uniprot_ac": "Q29RZ2", "gene_name": "PPWD1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q29RZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q29RZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ2" } ] } ] }, { "uniprot_ac": "Q2HJ89", "gene_name": "FKBP10", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2HJ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ89" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2HJ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ89" } ] } ] }, { "uniprot_ac": "Q2KJ44", "gene_name": "PTPA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2KJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ44" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2KJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ44" } ] } ] }, { "uniprot_ac": "Q2KJC8", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2KJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJC8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2KJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJC8" } ] } ] }, { "uniprot_ac": "Q2YDL5", "gene_name": "FKBP11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] } ] }, { "uniprot_ac": "Q32PA9", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q32PA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q32PA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA9" } ] } ] }, { "uniprot_ac": "Q5BIN5", "gene_name": "PIN1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] } ] }, { "uniprot_ac": "Q5E992", "gene_name": "PPIL1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5E992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5E992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ] } ] }, { "uniprot_ac": "Q9TRY0", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q9TRY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TRY0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q9TRY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TRY0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4S5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 211, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4S5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4S5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 135, "end_pos": 170, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" }, { "id": "PS50059", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50059" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPIase FKBP-type", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 135, "start_aa": "Gly", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.2.1.8", "ec_name": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "5.2.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8" }, { "id": "5.2.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.2.1.8" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5I4-1", "uniprot_ac": "F1N5I4", "uniprot_id": "F1N5I4_BOVIN", "mass": { "chemical_mass": 84120.0, "monoisotopic_mass": 84120.0 }, "refseq": { "ac": "XP_024836694", "name": "disintegrin and metalloproteinase domain-containing protein 11 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836694" }, "gene_names": [ { "name": "ADAM11", "type": "recommended", "evidence": [ { "id": "F1N5I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" } ] }, { "name": "ADAM11", "type": "synonym", "evidence": [ { "id": "XP_024836694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836694" } ] } ], "protein_names": [ { "name": "ADAM metallopeptidase domain 11", "type": "synonym", "evidence": [ { "id": "F1N5I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I4/entry#names_and_taxonomy" } ] }, { "name": "disintegrin and metalloproteinase domain-containing protein 11 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024836694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836694" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5I4", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADAM11", "url": "https://www.uniprot.org/uniprotkb/F1N5I4", "locus": { "chromosome": "19", "start_pos": 44504294, "end_pos": 44485241, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001735", "url": "https://www.ensembl.org/id/ENSBTAG00000001735" } ] } } ], "crossref": [ { "id": "F1N5I4", "url": "https://alphafold.ebi.ac.uk/entry/F1N5I4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001735", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001735", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522375", "url": "https://www.ncbi.nlm.nih.gov/gene/522375", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5I4", "url": "https://www.orthodb.org/?gene=F1N5I4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905:SF114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905:SF114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836694", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836694", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N5I4", "url": "https://www.uniprot.org/uniprotkb/F1N5I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5I4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5I4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRLRRWAFAALPLLLLPLLPSPGVGTWGPAGALRWRVSPHLGGPEAPEITEPSRLVGESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGLTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNFTYIVEPREMAGPWENAQGPLPHLIYRTPLLPAPLGCREPGCLFAAPDHPAPLNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFGQMRQSVVLTSNFAKSVVNLADVMYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEASDATHLFSGRTFQSTSSGAAYVGGICSLSRGGGVNEYDNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDNWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQALWGHAAADRFCYEKLNVEGTERGNCGRKGSGWVQCNKQDVLCGFLLCVNISGAPRLGDLGGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA", "length": 772, "header": "tr|F1N5I4-1|F1N5I4_BOVIN Isoform 1 of ADAM metallopeptidase domain 11 OS=Bos taurus OX=9913 GN=ADAM11 PE=4 SV=3 CANONICAL=F1N5I4-1" }, "isoforms": [ { "isoform_ac": "F1N5I4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5I4/entry", "sequence": { "sequence": "MRRLRRWAFAALPLLLLPLLPSPGVGTWGPAGALRWRVSPHLGGPEAPEITEPSRLVGESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGLTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNFTYIVEPREMAGPWENAQGPLPHLIYRTPLLPAPLGCREPGCLFAAPDHPAPLNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFGQMRQSVVLTSNFAKSVVNLADVMYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEASDATHLFSGRTFQSTSSGAAYVGGICSLSRGGGVNEYDNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDNWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQALWGHAAADRFCYEKLNVEGTERGNCGRKGSGWVQCNKQDVLCGFLLCVNISGAPRLGDLGGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA", "length": 772, "header": "tr|F1N5I4-1|F1N5I4_BOVIN Isoform 1 of ADAM metallopeptidase domain 11 OS=Bos taurus OX=9913 GN=ADAM11 PE=4 SV=3 CANONICAL=F1N5I4-1" }, "locus": { "chromosome": "19", "start_pos": 44503805, "end_pos": 44485438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002276.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002276.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002276.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002276.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "F1N5I4", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5I4", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N5I4", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 608, "end_pos": 610, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" }, { "id": "PS50214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Disintegrin", "eco_id": "ECO_0000259", "start_pos": 447, "end_pos": 534, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N5I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 676, "end_pos": 713, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N5I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I4" }, { "id": "PS50215", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M12B", "eco_id": "ECO_0000259", "start_pos": 242, "end_pos": 441, "start_aa": "Lys", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 608, "end_pos": 610 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N740-1", "uniprot_ac": "F1N740", "uniprot_id": "F1N740_BOVIN", "mass": { "chemical_mass": 442726.0, "monoisotopic_mass": 442726.0 }, "refseq": {}, "gene_names": [ { "name": "FRAS1", "type": "recommended", "evidence": [ { "id": "F1N740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ] } ], "protein_names": [ { "name": "Fraser extracellular matrix complex subunit 1", "type": "synonym", "evidence": [ { "id": "F1N740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N740/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FRAS1", "url": "https://www.uniprot.org/uniprotkb/F1N740", "locus": { "chromosome": "6", "start_pos": 93292876, "end_pos": 92761853, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010716", "url": "https://www.ensembl.org/id/ENSBTAG00000010716" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010716", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010716", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00064", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00064", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45739", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45739", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45739:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45739:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16184", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16184", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LGT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7Z8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N740-1", "url": "https://www.uniprot.org/uniprotkb/F1N740-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVFQVWLGMALTLAEFAALPHHSEGACVYQGSLLADATIWKPDSCQNCRCHGDIVICKPAVCRNPQCAFEKGEVLQIPANQCCPECVPRMPGSCHYEKKIHGHGTAWASSPCSTCSCTHGEVRCAPQPCPPLMCGHQELEFIPEGSCCPVCVGPGKSCSYEGHVFQDGDWPLSRCAKCVCRNGVAQCFAAQCPPLFCNQDETVIRVPGKCCPQCSSLSCSAAGQVYEHGEQWQENACTTCTCDQGQVRCHKQPCPPLRCEKGQRRARLPGQCCEDCVSPAGSCSHRGLVRYQDDMWKGSACEFCVCNRGQVTCQTAECAKVECAQGEELIHLEGKCCPECISRNGYCVYEENAEFMSSNASKVKRIPEGEKWEDGPCKVCECRGAQITCYEPSCPPCPVATLAQAVKGQCCPDCTSVRCHPDCLTCSQSPDHCDLCQDPTKLLRNGQCVHSCGLGFYQAGALCLACQPQCSTCTSGLECSSCQPPLLMQQGQCVSTCGIGFYQDRHSCAACHESCAACWGPTEKHCLACRDPLHVLREGGCESSCGNRFYNKQGTCSACDQSCKSCGPSSPRCLTCVEKTVLHDGKCISECPGGYYADATGRCKVCHNSCASCSGPTAAHCTACIHPQALRQGHCLPNCGEAFYPDHGVCKACHTSCLTCVGPAHSHCTQCRKPEDGLQFEPLSGANITSGECLSRCRAQFYLEITGLCEACHPSCSACAGMSPHNCTACWPSHMLLDGECLSQCPDGYFNQEGSCTECHPTCRQCHGPLESDCISCHPHVPLTAGSCRARCKEEQFLNLVGYCADCHPLCHHCAANLRDTGSVCLRCQNARNLLLGDRCVPDCPSGYFVERGACKKCHSSCRTCQGRGPFSCSSCDTGRVLSHLGTCSIACFPGHYLDDNRVCQPCNMHCGRCDSQASCTSCRDPSKVLLFGDCQHESCAPQYYLDFSTKTCKECDWSCNVCSGPLRTDCLQCMDGYVLQDGACVEQCSASFYRDLGLCKSCESHCLQCQGPHECTRCEEPFLLLEAQCVQECGKGFFADHANHKCTACPKGCLQCSRRDRCHLCDQGFFLKSGLCLSNCVPGFSAHSSNETCAGKIHTPSLHVNGSLTLAIGSMKPLDFFLLNVQDQGGRVEDLLFHVVSAPTNGQLVLSRNGKEAQLDKAGHFSWRDVKEKKVRFVHSREKPRKGYFSLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHINRGERGTITTQLLDIRDDDNPQDVVVEVLDPPLHGQLLQTLQSPAAPIYQFRLDELSRGLVQYVHDGSDSTSDITVLQANDGHSFQNILFHVRTVPKNDRGLRLVANSMVWVPEGGMLQITNRILQAEAPGASASEIIYKITQDHPQFGEVVLLVNMPADSPADGGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGVPAQSDSFRFQVSSATEAHTHLESRLFNIAILPHALETPQHFPGSLHMTAREDGLTVIQPHSLSFVNSERPNRKLIYNITLPLHPNQGIIEHRDQPHSPIRYFSQEDVNQGNIMYRPPTAAPHLQEIRAFSFAGLPESVKFHFTVSDGEHTSPEMALTIHLLRTDQYPPVFQVTAPLLVVSPGGSTSIELQLVVRDMETVPEELLFELRKPPQHGVLIKYTAGSPGPMATGDTFTYEDVEKNVLRYLHDGSSAREDSMEISVTDGLSATTVDVRVEVSPAEAQGPRLAAGASLSVTVASKSTAVITRSHLAYVDDSSSDPEIWIQITSLPMYGALLKTAGPEVEELSEISNFTMEDINNKKIRYSAAFETGGHPVTDSFHFSVSDMDHNRLDNQKFTITITPVKDPPPVIAFADLITVDEGGRTPLSFHHFFAAAAEDSFQEDAIIKLSALPQYGCIENTGTGDRFGPGTTSDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGNSRSEVHSINITIERKNDEPPRMTLRPLGVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPGHGHLLWRQTASEPLENGRVLAQGSSFTYQDILAGLVGYMPGGPGVAVDEFQFSLTDGLHTDTGRMEIYIELPTSDIPNLAVNRGLQVSAGSVATITDWHLKVTAPDSDDHQVMYILKEDPGVGRLQMVKRDSLEQISTRGPIQSFTQADISQGLIEYSHGKGESGGNFAFKFDVVDGEGNKLIGQSFSISVSEDKSPPVIITNKGLFLDENSVKKITTLQLSATDQEAEPTELVYRIIREPQLGRLEHTASPGIQISSFTQADLTSGNVQYIHSSETEKHSDAFSFTLSDGVHEVTQTFRITLRPVDDSLPHVQNFGMRVQEGVRKTITEFELKAVDEDTEAESVTFTVVQPPRHGTIERTADGQPFQLMSTFTMEDIYQSRVRYSHDGSNSLRDRFTFTVADGTNPFFIVEEGGKEIITAAPQQFWIDILPVDDGTPRIVTNLGLQWLEYMDGQATNLITKKELLTMDPDTEDLQLVYEITTGPKHGHVENKLQPGRAVATFTQEDVNLGLIRYVLHEEKIHEMMDSFQFLVKDSKPNVVNDNIFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTATSSSRVGSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDNVFEDVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKTYRVNESAGFLFAPIERKGDSSSIVSVICYTVPKSAMGSSLYALESGSDFKSRGMSAESRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALTGASDNARIGRMASAKVLIAGPNDASTVSLGNTAFTISEDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRKVEFGPGVTEQYCTLTILDDTQYPVIEGLETFVVFLSSPQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPIIRSGDLSYESSVRCYTQGLSAQVMEDFEERRNADSSRITFLKGEKMKNCTVYIHDDSMFEPEEQFRVYLGRPLGNHWSGARVGKNHMATITISNDEDAPTIEFEEAAYQVREPSGPDATAILNVKVIRRGDQNRTSKIRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEVTKEGVKKSPSPGYPLICVTPCDPHFPKYAVMKERCIEAGINQTSVQFSWEVAAPTDGNGARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNVVTIGTDSAICHTPVVAGTARGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLHNLHFLLSESIYRHQHVCSNLVTTRDLRGISEAGFLDDRVHDSMALGPGYDRPFQFDSSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLHVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAKFRGQFVMEHHTLPDVKSFILTPDHLGGIEFDLQLLWSAQTFDSPYQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWADPGEKPLACTAHAPERFLIPIAFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLNSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRSQPEVTDKYFHDVPFEAHFASELPDFHVVSSMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDTISGPRVQRSLTAPLRRHRRDLADPSGWLSLDESLIYDNEGDQVKNGTNMKSLNLEMQEPVVAASLSQTGASIGSALAAIMLLLLVSLVACFITRKCQKQRKKPPTGDILEEYPLNTKVDMPKRGADRVEKNVDRQYCTVRNVNILGEAERAYVFRGAKVKKLNLEVRVHNNLQDGTEV", "length": 4010, "header": "tr|F1N740-1|F1N740_BOVIN Isoform 1 of Fraser extracellular matrix complex subunit 1 OS=Bos taurus OX=9913 GN=FRAS1 PE=3 SV=4 CANONICAL=F1N740-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGT4/entry", "sequence": { "sequence": "MSVFQVWLGMALTLAEFAALPHHSEGACVYQGSLLADATIWKPDSCQNCRCHGDIVICKPAVCRNPQCAFEKGEVLQIPANQCCPECVPRMPGSCHYEKKIHGHGTAWASSPCSTCSCTHGEVRCAPQPCPPLMCGHQELEFIPEGSCCPVCVGPGKSCSYEGHVFQDGDWPLSRCAKCVCRNGVAQCFAAQCPPLFCNQDETVIRVPGKCCPQCSSLSCSAAGQVYEHGEQWQENACTTCTCDQGQVRCHKQPCPPLRCEKGQRRARLPGQCCEDCVSPAGSCSHRGLVRYQDDMWKGSACEFCVCNRGQVTCQTAECAKVECAQGEELIHLEGKCCPECISRNGYCVYEENAEFMSSNASKVKRIPEGEKWEDGPCKVCECRGAQITCYEPSCPPCPVATLAQAVKGQCCPDCTSVRCHPDCLTCSQSPDHCDLCQDPTKLLRNGQCVHSCGLGFYQAGALCLACQPQCSTCTSGLECSSCQPPLLMQQGQCVSTCGIGFYQDRHSCAACHESCAACWGPTEKHCLACRDPLHVLREGGCESSCGNRFYNKQGTCSACDQSCKSCGPSSPRCLTCVEKTVLHDGKCISECPGGYYADATGRCKVCHNSCASCSGPTAAHCTACIHPQALRQGHCLPNCGEAFYPDHGVCKACHTSCLTCVGPAHSHCTQCRKPEDGLQFEPLSGANITSGECLSRCRAQFYLEITGLCEGQNLDFCQNLEVIPACFGVLPTEN", "length": 735, "header": "tr|A0A3Q1LGT4-1|F1N740_BOVIN Computationally mapped isoform of Fraser extracellular matrix complex subunit 1 OS=Bos taurus OX=9913 GN=FRAS1 PE=3 SV=2 CANONICAL=F1N740-1" }, "locus": { "chromosome": "6", "start_pos": 93042319, "end_pos": 92761853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080351.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080351.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057753.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057753.2" } ] } }, { "isoform_ac": "A0A3Q1N7Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7Z8/entry", "sequence": { "sequence": "MSVFQVWLGMALTLAEFAALPHHSEGACVYQGSLLADATIWKPDSCQNCRCHGDIVICKPAVCRNPQCAFEKGEVLQIPANQCCPECVPRMPGSCHYEKKIHGHGTAWASSPCSTCSCTHGEVRCAPQPCPPLMCGHQELEFIPEGSCCPVCVGPGKSCSYEGHVFQDGDWPLSRCAKCVCRNGVAQCFAAQCPPLFCNQDETVIRVPGKCCPQCSSLSCSAAGQVYEHGEQWQENACTTCTCDQGQVRCHKQPCPPLRCEKGQRRARLPGQCCEDCVSPAGSCSHRGLVRYQDDMWKGSACEFCVCNRGQVTCQTAECAKVECAQGEELIHLEGKCCPECISRNGYCVYEENAEFMSSNASKVKRIPEGEKWEDGPCKVCECRGAQITCYEPSCPPCPVATLAQAVKGQCCPDCTSVRCHPDCLTCSQSPDHCDLCQDPTKLLRNGQCVHSCGLGFYQAGALCLACQPQCSTCTSGLECSSCQPPLLMQQGQCVSTCGIGFYQDRHSCAACHESCAACWGPTEKHCLACRDPLHVLREGGCESSCGNRFYNKQGTCSACDQSCKSCGPSSPRCLTCVEKTVLHDGKCISECPGGYYADATGRCKVCHNSCASCSGPTAAHCTACIHPQALRQGHCLPNCGEAFYPDHGVCKACHTSCLTCVGPAHSHCTQCRKPEDGLQFEPLSGANITSGECLSRCRAQFYLEITGLCEACHPSCSACAGMSPHNCTACWPSHMLLDGECLSQCPDGYFNQEGSCTECHPTCRQCHGPLESDCISCHPHVPLTAGSCRARCKEEQFLNLVGYCADCHPLCHHCAANLRDTGSVCLRCQNARNLLLGDRCVPDCPSGYFVERGACKKCHSSCRTCQGRGPFSCSSCDTGRVLSHLGTCSIACFPGHYLDDNRVCQPCNMHCGRCDSQASCTSCRDPSKVLLFGDCQHESCAPQYYLDFSTKTCKECDWSCNVCSGPLRTDCLQCMDGYVLQDGACVEQCSASFYRDLGLCKSCESHCLQCQGPHECTRCEEPFLLLEAQCVQECGKGFFADHANHKCTACPKGCLQCSRRDRCHLCDQGFFLKSGLCLSNCVPGFSAHSSNETCAGKIHTPSLHVNGSLTLAIGSMKPLDFFLLNVQDQGGRVEDLLFHVVSAPTNGQLVLSRNGKEAQLDKAGHFSWRDVKEKKVRFVHSREKPRKGYFSLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHINRGERGTITTQLLDIRDDDNPQDVVVEVLDPPLHGQLLQTLQSPAAPIYQFRLDELSRGLVQYVHDGSDSTSDITVLQANDGHSFQNILFHVRTVPKNDRGLRLVANSMVWVPEGGMLQITNRILQAEAPGASASEIIYKITQDHPQFGEVVLLVNMPADSPADGGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGVPAQSDSFRFQVSSATEAHTHLESRLFNIAILPHALETPQHFPGSLHMTAREDGLTVIQPHSLSFVNSERPNRKLIYNITLPLHPNQGIIEHRDQPHSPIRYFSQEDVNQGNIMYRPPTAAPHLQEIRAFSFAGLPESVKFHFTVSDGEHTSPEMALTIHLLRTDQYPPVFQVTAPLLVVSPGGSTSIELQLVVRDMETVPEELLFELRKPPQHGVLIKYTAGSPGPMATGDTFTYEDVEKNVLRYLHDGSSAREDSMEISVTDGLSATTVDVRVEVSPAEAQGPRLAAGASLSVTVASKSTAVITRSHLAYVDDSSSDPEIWIQITSLPMYGALLKTAGPEVEELSEISNFTMEDINNKKIRYSAAFETGGHPVTDSFHFSVSDMDHNRLDNQKFTITITPVKDPPPVIAFADLITVDEGGRTPLSFHHFFAAAAEDSFQEDAIIKLSALPQYGCIENTGTGDRFGPGTTSDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGNSRSEVHSINITIERKNDEPPRMTLRPLGVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPGHGHLLWRQTASEPLENGRVLAQGSSFTYQDILAGLVGYMPGGPGVAVDEFQFSLTDGLHTDTGRMEIYIELPTSDIPNLAVNRGLQVSAGSVATITDWHLKVTAPDSDDHQVMYILKEDPGVGRLQMVKRDSLEQISTRGPIQSFTQADISQGQALLLPDFQKLHPL", "length": 2167, "header": "tr|A0A3Q1N7Z8-1|F1N740_BOVIN Computationally mapped isoform of Fraser extracellular matrix complex subunit 1 OS=Bos taurus OX=9913 GN=FRAS1 PE=3 SV=2 CANONICAL=F1N740-1" }, "locus": { "chromosome": "6", "start_pos": 93206442, "end_pos": 92761853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080436.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080436.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067012.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067012.2" } ] } }, { "isoform_ac": "F1N740-1", "url": "https://www.uniprot.org/uniprotkb/F1N740/entry", "sequence": { "sequence": "MSVFQVWLGMALTLAEFAALPHHSEGACVYQGSLLADATIWKPDSCQNCRCHGDIVICKPAVCRNPQCAFEKGEVLQIPANQCCPECVPRMPGSCHYEKKIHGHGTAWASSPCSTCSCTHGEVRCAPQPCPPLMCGHQELEFIPEGSCCPVCVGPGKSCSYEGHVFQDGDWPLSRCAKCVCRNGVAQCFAAQCPPLFCNQDETVIRVPGKCCPQCSSLSCSAAGQVYEHGEQWQENACTTCTCDQGQVRCHKQPCPPLRCEKGQRRARLPGQCCEDCVSPAGSCSHRGLVRYQDDMWKGSACEFCVCNRGQVTCQTAECAKVECAQGEELIHLEGKCCPECISRNGYCVYEENAEFMSSNASKVKRIPEGEKWEDGPCKVCECRGAQITCYEPSCPPCPVATLAQAVKGQCCPDCTSVRCHPDCLTCSQSPDHCDLCQDPTKLLRNGQCVHSCGLGFYQAGALCLACQPQCSTCTSGLECSSCQPPLLMQQGQCVSTCGIGFYQDRHSCAACHESCAACWGPTEKHCLACRDPLHVLREGGCESSCGNRFYNKQGTCSACDQSCKSCGPSSPRCLTCVEKTVLHDGKCISECPGGYYADATGRCKVCHNSCASCSGPTAAHCTACIHPQALRQGHCLPNCGEAFYPDHGVCKACHTSCLTCVGPAHSHCTQCRKPEDGLQFEPLSGANITSGECLSRCRAQFYLEITGLCEACHPSCSACAGMSPHNCTACWPSHMLLDGECLSQCPDGYFNQEGSCTECHPTCRQCHGPLESDCISCHPHVPLTAGSCRARCKEEQFLNLVGYCADCHPLCHHCAANLRDTGSVCLRCQNARNLLLGDRCVPDCPSGYFVERGACKKCHSSCRTCQGRGPFSCSSCDTGRVLSHLGTCSIACFPGHYLDDNRVCQPCNMHCGRCDSQASCTSCRDPSKVLLFGDCQHESCAPQYYLDFSTKTCKECDWSCNVCSGPLRTDCLQCMDGYVLQDGACVEQCSASFYRDLGLCKSCESHCLQCQGPHECTRCEEPFLLLEAQCVQECGKGFFADHANHKCTACPKGCLQCSRRDRCHLCDQGFFLKSGLCLSNCVPGFSAHSSNETCAGKIHTPSLHVNGSLTLAIGSMKPLDFFLLNVQDQGGRVEDLLFHVVSAPTNGQLVLSRNGKEAQLDKAGHFSWRDVKEKKVRFVHSREKPRKGYFSLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHINRGERGTITTQLLDIRDDDNPQDVVVEVLDPPLHGQLLQTLQSPAAPIYQFRLDELSRGLVQYVHDGSDSTSDITVLQANDGHSFQNILFHVRTVPKNDRGLRLVANSMVWVPEGGMLQITNRILQAEAPGASASEIIYKITQDHPQFGEVVLLVNMPADSPADGGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGVPAQSDSFRFQVSSATEAHTHLESRLFNIAILPHALETPQHFPGSLHMTAREDGLTVIQPHSLSFVNSERPNRKLIYNITLPLHPNQGIIEHRDQPHSPIRYFSQEDVNQGNIMYRPPTAAPHLQEIRAFSFAGLPESVKFHFTVSDGEHTSPEMALTIHLLRTDQYPPVFQVTAPLLVVSPGGSTSIELQLVVRDMETVPEELLFELRKPPQHGVLIKYTAGSPGPMATGDTFTYEDVEKNVLRYLHDGSSAREDSMEISVTDGLSATTVDVRVEVSPAEAQGPRLAAGASLSVTVASKSTAVITRSHLAYVDDSSSDPEIWIQITSLPMYGALLKTAGPEVEELSEISNFTMEDINNKKIRYSAAFETGGHPVTDSFHFSVSDMDHNRLDNQKFTITITPVKDPPPVIAFADLITVDEGGRTPLSFHHFFAAAAEDSFQEDAIIKLSALPQYGCIENTGTGDRFGPGTTSDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGNSRSEVHSINITIERKNDEPPRMTLRPLGVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPGHGHLLWRQTASEPLENGRVLAQGSSFTYQDILAGLVGYMPGGPGVAVDEFQFSLTDGLHTDTGRMEIYIELPTSDIPNLAVNRGLQVSAGSVATITDWHLKVTAPDSDDHQVMYILKEDPGVGRLQMVKRDSLEQISTRGPIQSFTQADISQGLIEYSHGKGESGGNFAFKFDVVDGEGNKLIGQSFSISVSEDKSPPVIITNKGLFLDENSVKKITTLQLSATDQEAEPTELVYRIIREPQLGRLEHTASPGIQISSFTQADLTSGNVQYIHSSETEKHSDAFSFTLSDGVHEVTQTFRITLRPVDDSLPHVQNFGMRVQEGVRKTITEFELKAVDEDTEAESVTFTVVQPPRHGTIERTADGQPFQLMSTFTMEDIYQSRVRYSHDGSNSLRDRFTFTVADGTNPFFIVEEGGKEIITAAPQQFWIDILPVDDGTPRIVTNLGLQWLEYMDGQATNLITKKELLTMDPDTEDLQLVYEITTGPKHGHVENKLQPGRAVATFTQEDVNLGLIRYVLHEEKIHEMMDSFQFLVKDSKPNVVNDNIFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTATSSSRVGSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDNVFEDVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKTYRVNESAGFLFAPIERKGDSSSIVSVICYTVPKSAMGSSLYALESGSDFKSRGMSAESRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALTGASDNARIGRMASAKVLIAGPNDASTVSLGNTAFTISEDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRKVEFGPGVTEQYCTLTILDDTQYPVIEGLETFVVFLSSPQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPIIRSGDLSYESSVRCYTQGLSAQVMEDFEERRNADSSRITFLKGEKMKNCTVYIHDDSMFEPEEQFRVYLGRPLGNHWSGARVGKNHMATITISNDEDAPTIEFEEAAYQVREPSGPDATAILNVKVIRRGDQNRTSKIRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEVTKEGVKKSPSPGYPLICVTPCDPHFPKYAVMKERCIEAGINQTSVQFSWEVAAPTDGNGARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNVVTIGTDSAICHTPVVAGTARGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLHNLHFLLSESIYRHQHVCSNLVTTRDLRGISEAGFLDDRVHDSMALGPGYDRPFQFDSSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLHVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAKFRGQFVMEHHTLPDVKSFILTPDHLGGIEFDLQLLWSAQTFDSPYQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWADPGEKPLACTAHAPERFLIPIAFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLNSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRSQPEVTDKYFHDVPFEAHFASELPDFHVVSSMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDTISGPRVQRSLTAPLRRHRRDLADPSGWLSLDESLIYDNEGDQVKNGTNMKSLNLEMQEPVVAASLSQTGASIGSALAAIMLLLLVSLVACFITRKCQKQRKKPPTGDILEEYPLNTKVDMPKRGADRVEKNVDRQYCTVRNVNILGEAERAYVFRGAKVKKLNLEVRVHNNLQDGTEV", "length": 4010, "header": "tr|F1N740-1|F1N740_BOVIN Isoform 1 of Fraser extracellular matrix complex subunit 1 OS=Bos taurus OX=9913 GN=FRAS1 PE=3 SV=4 CANONICAL=F1N740-1" }, "locus": { "chromosome": "6", "start_pos": 93291872, "end_pos": 92761853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060947.5", "url": "https://www.ensembl.org/id/ENSBTAT00000060947.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053681.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053681.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2845, "start_aa": "Thr", "end_pos": 2845, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2845", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3484, "start_aa": "Thr", "end_pos": 3484, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3484", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3620, "start_aa": "Thr", "end_pos": 3620, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3620", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 618, "start_aa": "Thr", "end_pos": 618, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr618", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "system development", "id": "GO:0048731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048731", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" }, { "name": "cell communication", "id": "GO:0007154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007154", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" }, { "name": "epithelial structure maintenance", "id": "GO:0010669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010669", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N740", "url": "https://www.uniprot.org/uniprotkb/F1N740" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1092, "end_pos": 1094, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1107, "end_pos": 1109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1502, "end_pos": 1504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1775, "end_pos": 1777, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1946, "end_pos": 1948, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1976, "end_pos": 1978, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2561, "end_pos": 2563, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2666, "end_pos": 2668, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2684, "end_pos": 2686, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2910, "end_pos": 2912, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2987, "end_pos": 2989, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3072, "end_pos": 3074, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3220, "end_pos": 3222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3678, "end_pos": 3680, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3877, "end_pos": 3879, "annotation": "n_glycosylation_sequon" }, { "start_pos": 688, "end_pos": 690, "annotation": "n_glycosylation_sequon" }, { "start_pos": 727, "end_pos": 729, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N740" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 88, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 618, 2845, 3484, 3620 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1092, "end_pos": 1094 }, { "start_pos": 1107, "end_pos": 1109 }, { "start_pos": 1502, "end_pos": 1504 }, { "start_pos": 1775, "end_pos": 1777 }, { "start_pos": 1946, "end_pos": 1948 }, { "start_pos": 1976, "end_pos": 1978 }, { "start_pos": 2561, "end_pos": 2563 }, { "start_pos": 2666, "end_pos": 2668 }, { "start_pos": 2684, "end_pos": 2686 }, { "start_pos": 2910, "end_pos": 2912 }, { "start_pos": 2987, "end_pos": 2989 }, { "start_pos": 3072, "end_pos": 3074 }, { "start_pos": 3220, "end_pos": 3222 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 3678, "end_pos": 3680 }, { "start_pos": 3877, "end_pos": 3879 }, { "start_pos": 688, "end_pos": 690 }, { "start_pos": 727, "end_pos": 729 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QRH3-1", "uniprot_ac": "F6QRH3", "uniprot_id": "F6QRH3_BOVIN", "mass": { "chemical_mass": 30246.0, "monoisotopic_mass": 30246.0 }, "refseq": {}, "gene_names": [ { "name": "TPRG1L", "type": "recommended", "evidence": [ { "id": "F6QRH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" } ] } ], "protein_names": [ { "name": "Tumor protein p63 regulated 1 like", "type": "synonym", "evidence": [ { "id": "F6QRH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QRH3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QRH3", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPRG1L", "url": "https://www.uniprot.org/uniprotkb/F6QRH3", "locus": { "chromosome": "16", "start_pos": 49419778, "end_pos": 49422661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015857", "url": "https://www.ensembl.org/id/ENSBTAG00000015857" } ] } } ], "crossref": [ { "id": "F6QRH3", "url": "https://alphafold.ebi.ac.uk/entry/F6QRH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015857", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015857", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR022158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WNPWSSN", "url": "https://omabrowser.org/oma/group/WNPWSSN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LHQ9", "url": "https://www.orthodb.org/?gene=A0A3Q1LHQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QRH3", "url": "https://www.orthodb.org/?gene=F6QRH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31108:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31108:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LHQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QRH3", "url": "https://www.uniprot.org/uniprotkb/F6QRH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QRH3-1", "url": "https://www.uniprot.org/uniprotkb/F6QRH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGSGGGGGGGRPGVGTPLRQTLWPLSVHDPTRRARVKEYFVFRPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEVDHWNNEKERLVLITDQALLICKYDFISLQCQQVVRVALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 274, "header": "tr|F6QRH3-1|F6QRH3_BOVIN Isoform 1 of Tumor protein p63 regulated 1 like OS=Bos taurus OX=9913 GN=TPRG1L PE=3 SV=2 CANONICAL=F6QRH3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LHQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHQ9/entry", "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGSGGGGGGGRPGVGTPLRQTLWPLSVHDPTRRARVKEYFVFRVRLEVGAGAGEGVGLVDHWNNEKERLVLITDQALLICKYDFISLQCQQVVRVALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 258, "header": "tr|A0A3Q1LHQ9-1|F6QRH3_BOVIN Computationally mapped isoform of Tumor protein p63 regulated 1 like OS=Bos taurus OX=9913 GN=TPRG1L PE=3 SV=1 CANONICAL=F6QRH3-1" }, "locus": { "chromosome": "16", "start_pos": 49422622, "end_pos": 49420100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071937.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071937.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058328.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058328.1" } ] } }, { "isoform_ac": "A0AAA9TTZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTZ4/entry", "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGSGGGGGGGRPGVGTPLRQTLWPLSVHDPTRRARVKEYFVFRPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 215, "header": "tr|A0AAA9TTZ4-1|F6QRH3_BOVIN Computationally mapped isoform of Tumor protein p63 regulated 1 like OS=Bos taurus OX=9913 GN=TPRG1L PE=3 SV=1 CANONICAL=F6QRH3-1" }, "locus": { "chromosome": "16", "start_pos": 49422622, "end_pos": 49420100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089305.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089305.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100006.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100006.1" } ] } }, { "isoform_ac": "F6QRH3-1", "url": "https://www.uniprot.org/uniprotkb/F6QRH3/entry", "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGSGGGGGGGRPGVGTPLRQTLWPLSVHDPTRRARVKEYFVFRPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEVDHWNNEKERLVLITDQALLICKYDFISLQCQQVVRVALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 274, "header": "tr|F6QRH3-1|F6QRH3_BOVIN Isoform 1 of Tumor protein p63 regulated 1 like OS=Bos taurus OX=9913 GN=TPRG1L PE=3 SV=2 CANONICAL=F6QRH3-1" }, "locus": { "chromosome": "16", "start_pos": 49422622, "end_pos": 49420100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021078.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021078.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021078.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021078.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QRM0-1", "protein_name": "Tumor protein p63 regulated 1 like", "gene_name": "TPRG1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGGGGSGGGGGGGRPGVGTPLRQTLWPLSIHDPTRRARVKEYFVFRPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEVDHWNNEKERLVLITDQSLLICKYDFISLQCQQVVRVALSAVDTISYGEFQFPPKSLNKREGVGVRIQWDKQSRPSFISRWNPWSTSVPYTTFTEHPMAGVDEKTASLCQLEDFKALLIQAVKKAQKESPWPGQAGGVLVLERPLLIETYVGLMSFISNEAKLGYSMTRGRIGF", "length": 277 }, "evidence": [ { "id": "F6QRH3", "url": "https://omabrowser.org/oma/group/F6QRH3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A8WCF8-1", "protein_name": "Tumor protein p63-regulated gene 1-like protein", "gene_name": "Tprg1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLQLRDTVDSAGTSPTAVLAAGEDAGAGRQGAGTPLRQTLWPLNVHDPTRRARVKEYFVFRPGTIEQAVEEIRAVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTDQSLLICKYDFISLQCQQVVRVALSAVDTISCGEFQFPPKSLNKREGFGVRIQWDKQSRPSFINRWNPWSTNMPYATFIEHPMAGMDEKTASLCHLESFKALLIQAVKKAQKESPLPGQANNVLVLDRPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 266 }, "evidence": [ { "id": "F6QRH3", "url": "https://omabrowser.org/oma/group/F6QRH3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B8A4V5-1", "protein_name": "Tumor protein p63-regulated gene 1-like protein", "gene_name": "tprg1l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLQLNDSVITLDPESPGAAVLLSADCDDGLEVSARAGASVACCSSLQTLTPFHVHNPTMRAKVKDYFVFRPGTIEQAVNDIRTVALPSEDGEVLSVWLLAEVDHWNNEKERLVLITERSLLVCKYDFINLQCQQVIRISLNAVDTISIGEFEFPPKSLNKREGTGIRVQWDKRPRASFMNRWNPWSTDIPYATFTEHPMAHADEKVASLCQLENFKTQLIQAVKKAHKEYPIPGRANGVLILERPLLIETYLGIMSFINNEAKLGYAMTRGKIGF", "length": 275 }, "evidence": [ { "id": "F6QRH3", "url": "https://omabrowser.org/oma/group/F6QRH3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1P107-1", "protein_name": "Tumor protein p63 regulated 1 like", "gene_name": "TPRG1L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLQLRDPEEGGPEDEEEAAGGAAALLVPGGPEPPFSAAPPRQKLRPLNVRTASRAGRLKEYFVFRPGTIEQAVSEIRAVVMPTEDGDVESVWLLTEIDHWNNEKERLVLITDRSLLICKYDFVGLQCQHVTRIALNAIDTISVGEFEFPPKSLNKREGVGIRIQWDKRSRASFINRWNPWSTNVPYATFTEHPMADADEKVASLCLLENFKTQLIQAVKKAHKEWPLPGRANGVLVLERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 270 }, "evidence": [ { "id": "F6QRH3", "url": "https://omabrowser.org/oma/group/F6QRH3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5T0D9-1", "protein_name": "Tumor protein p63-regulated gene 1-like protein", "gene_name": "TPRG1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQLRDSVDSAGTSPTAVLAAGEEVGAGGGPGGGRPGAGTPLRQTLWPLSIHDPTRRARVKEYFVFRPGSIEQAVEEIRVVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTEQSLLICKYDFISLQCQQVVRIALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFINRWNPWSTNVPYATFTEHPMAGADEKTASLCQLESFKALLIQAVKKAQKESPLPGQANGVLILERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 272 }, "evidence": [ { "id": "F6QRH3", "url": "https://omabrowser.org/oma/group/F6QRH3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DBS2-1", "protein_name": "Tumor protein p63-regulated gene 1-like protein", "gene_name": "Tprg1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLQLRDTVDSAGTSPTAVLAAGEDAGAGRPGAGTPLRQTLWPLNVHDPTRRARVKEYFVFRPGTIEQAVEEIRAVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTDQSLLICKYDFISLQCQQVVRVALSAVDTISCGEFQFPPKSLNKREGFGVRIQWDKQSRPSFINRWNPWSTNMPYATFIEHPMAGMDEKTASLCHLESFKALLIQAVKKAQKESPLPGQANTVLVLERPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 266 }, "evidence": [ { "id": "F6QRH3", "url": "https://omabrowser.org/oma/group/F6QRH3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F6QRH3", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F6QRH3", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F6QRH3", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "F6QRH3", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QRH3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 274, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QRH3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QRH3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QRH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QRH3" }, { "id": "PS51791", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51791" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HSac2", "eco_id": "ECO_0000259", "start_pos": 67, "end_pos": 239, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1K2-1", "uniprot_ac": "F1N1K2", "uniprot_id": "F1N1K2_BOVIN", "mass": { "chemical_mass": 65632.0, "monoisotopic_mass": 65632.0 }, "refseq": {}, "gene_names": [ { "name": "TRIP4", "type": "recommended", "evidence": [ { "id": "F1N1K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ] } ], "protein_names": [ { "name": "Activating signal cointegrator 1", "type": "recommended", "evidence": [ { "id": "F1N1K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K2/entry#names_and_taxonomy" } ] }, { "name": "Thyroid receptor-interacting protein 4", "type": "synonym", "evidence": [ { "id": "F1N1K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2#function" }, { "database": "UniProtKB", "id": "ARBA00055901", "url": "https://www.uniprot.org/uniprotkb/ARBA00055901#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIP4", "url": "https://www.uniprot.org/uniprotkb/F1N1K2", "locus": { "chromosome": "10", "start_pos": 45587771, "end_pos": 45639642, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014493", "url": "https://www.ensembl.org/id/ENSBTAG00000014493" } ] } } ], "crossref": [ { "id": "F1N1K2", "url": "https://alphafold.ebi.ac.uk/entry/F1N1K2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06554", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06554", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533430", "url": "https://www.ncbi.nlm.nih.gov/gene/533430", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFNSYRH", "url": "https://omabrowser.org/oma/group/EFNSYRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKE3", "url": "https://www.orthodb.org/?gene=A0A3Q1LKE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJH2", "url": "https://www.orthodb.org/?gene=A0A3Q1MJH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1K2", "url": "https://www.orthodb.org/?gene=F1N1K2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12963", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12963", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12963:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12963:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23135", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23135", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKE3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJH2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJH2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1K2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1K2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVAGAASREQLVGWCTEQLRKSFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEELVTKWQKNDQELTSDALQQSFKKDDGQRSGDQLKRSRRKGRNKQEAPAFTEPDTTTEVKTPFDLAKAQDNSSSLKKKTKFVSLYTKEGQDKLAVLIPGRHPCDCLGQKHKLINNCLVCGRIVCEQEGSGPCLFCGSLVCTHEERDILQRDSNKSQKLLKKLMSGTENSGKVDISTKDLLPHQELRFKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKIEREAIQKREEELREFRHASRLSKKITIDFAGRKIVEDEDPLAEYHSKLDEAIHAIANGTLNQPVTKLDRSSEEPLGLLVNPNLYQSPPQWIDQMGAASQKKAFHPAGSGLEFSSSRHQFRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRNWYTPHRGRLWIAATAKRPSPQEVSELQTTYLLLRGKGVEFPSDYPSGCLLGCVDLIDCLSQKQFKDQYPDISQEESDSPFVFICTNPQEMIVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAG", "length": 579, "header": "tr|F1N1K2-1|F1N1K2_BOVIN Isoform 1 of Activating signal cointegrator 1 OS=Bos taurus OX=9913 GN=TRIP4 PE=4 SV=3 CANONICAL=F1N1K2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKE3/entry", "sequence": { "sequence": "MAVAGAASREQLVGWCTEQLRKSFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEELVTKWQKNDQELTSDALQQSFKKDDGQRSGDQLKRSRRKGRNKQEAPAFTEPDTTTEVKTPFDLAKAQDNSSSLKKKTKFVSLYTKEGQDKLAVLIPGRHPCDCLGQKHKLINNCLVCGRIVCEQEGSGPCLFCGSLVCTHEERDILQRDSNKSQKLLKKLMSGTENSGKVDISTKDLLPHQELRFKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKIEREAIQKREEELREFRHASRLSKKITIDFAGRKIVEDEDPLAEYHSKLDEAIHAIANGTLNQPVTKLDRSSEEPLGLLVNPNLYQSPPQWIDQMGAASQKKAFHPAGSGLEFSSSRHQFRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRNWYTPHRGRLWIAATAKRPSPQEVSELQTTYLLLRGKGVEFPSDYPSGCLLGCVDLIDCLSQKQFKDQCLLRKKKKNQ", "length": 532, "header": "tr|A0A3Q1LKE3-1|F1N1K2_BOVIN Computationally mapped isoform of Activating signal cointegrator 1 OS=Bos taurus OX=9913 GN=TRIP4 PE=4 SV=1 CANONICAL=F1N1K2-1" }, "locus": { "chromosome": "10", "start_pos": 45639621, "end_pos": 45612206, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072698.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072698.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060025.1" } ] } }, { "isoform_ac": "A0A3Q1MJH2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJH2/entry", "sequence": { "sequence": "MAVAGAASREQLVGWCTEQLRKSFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEELVTKWQKNDQELTSDALQQSFKKDDGQRSGDQLKRSRRKGRNKQEAPAFTEPDTTTEVKTPFDLAKAQDNSSSLKKKTKFVSLYTKEGQDKLAVLIPGRHPCDCLGQKHKLINNCLVCGRIVCEQEGSGPCLFCGSLVCTHEERDILQRDSNKSQKLLKKLMSGTENSGKVDISTKDLLPHQELRFKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKIEREAIQKREEELREFRHASRLSKKITIDFAGRKIVEDEDPLAEYHSKLDEAIHAIANGTLNQPVTKLDRSSEEPLGLLVNPNLYQSPPQWIDQMGAASQKKAFHPAGSGLEFSSSRHQFRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRNWYTPHRGRLWIAATAKRPSPQEVSELQTTYLLLRGKGVEFPSDYPSGCLLGCVDLIDCLSQKQFKDQVSKEYFFWTDA", "length": 533, "header": "tr|A0A3Q1MJH2-1|F1N1K2_BOVIN Computationally mapped isoform of Activating signal cointegrator 1 OS=Bos taurus OX=9913 GN=TRIP4 PE=4 SV=2 CANONICAL=F1N1K2-1" }, "locus": { "chromosome": "10", "start_pos": 45639621, "end_pos": 45613188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067613.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067613.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070926.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070926.2" } ] } }, { "isoform_ac": "F1N1K2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1K2/entry", "sequence": { "sequence": "MAVAGAASREQLVGWCTEQLRKSFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEELVTKWQKNDQELTSDALQQSFKKDDGQRSGDQLKRSRRKGRNKQEAPAFTEPDTTTEVKTPFDLAKAQDNSSSLKKKTKFVSLYTKEGQDKLAVLIPGRHPCDCLGQKHKLINNCLVCGRIVCEQEGSGPCLFCGSLVCTHEERDILQRDSNKSQKLLKKLMSGTENSGKVDISTKDLLPHQELRFKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKIEREAIQKREEELREFRHASRLSKKITIDFAGRKIVEDEDPLAEYHSKLDEAIHAIANGTLNQPVTKLDRSSEEPLGLLVNPNLYQSPPQWIDQMGAASQKKAFHPAGSGLEFSSSRHQFRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRNWYTPHRGRLWIAATAKRPSPQEVSELQTTYLLLRGKGVEFPSDYPSGCLLGCVDLIDCLSQKQFKDQYPDISQEESDSPFVFICTNPQEMIVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAG", "length": 579, "header": "tr|F1N1K2-1|F1N1K2_BOVIN Isoform 1 of Activating signal cointegrator 1 OS=Bos taurus OX=9913 GN=TRIP4 PE=4 SV=3 CANONICAL=F1N1K2-1" }, "locus": { "chromosome": "10", "start_pos": 45639621, "end_pos": 45588003, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019269.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019269.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019269.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019269.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IR18-1", "protein_name": "Activating signal cointegrator 1", "gene_name": "trip4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDSLLRWTVDKLKHGFGLDASDDIVQYILSIDNADEIVEYVGDLLQGTEGNKQEFVDELVQRWQRCQTQTSDGLGGVLRKEVVMEELDTAPKDTQKKSKRKGRNKQEIVTVSQAEPEPVRTPIDLMKAQESSNSSSVKKKSKFVNLYAKEGKDKLAVLLPGRQACECLAQKHRLINNCLSCGRIVCEQEGSGPCLFCGSLVCTNEEQEILQRDSNKSQKLRKKLMGEGTEREYLPHQESKMKAGLEKAVKHKDKLLEFDKNSVKRTQVLDDESDYFATDSNQWLSPGEREALRKREEELRELRHASRKDRKITLDFAGRRVLDEGENLSPYYQKFDETVKAINTGSFGQKAKHSAPADRQHFRELVNPNILQSAPEWVDVASSNPSRKSSSKAASGKETSERSRLRLQDKELQEIADGGWCLSMHQPWASLLVKGIKRVEGRTWYTSHRGRLWIAAAANRPTPQEIAEVEAMYRHLYKHEPQFPAEYPTGCLLGCVNVSDCLSQEQFREQYPQISEESTSPFVFICSNPQELVVKFPMKGKHKIWKLESQSHQSAKKCLMQPA", "length": 564 }, "evidence": [ { "id": "F1N1K2", "url": "https://omabrowser.org/oma/group/F1N1K2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZUQ7-1", "protein_name": "Activating signal cointegrator 1", "gene_name": "TRIP4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLCSSTPGTGAPGPRFRGTAVRRHFPSPHEDGGARRPAGLVRAAPARRLRAGRGRGGRAVSLPAATGCPVSRRCCAPPFCFRFPDPFPWSSLGPPRPLYLLRVPLPLTALLRSPTCPLVLLDSWFASSVYILSITSEDEIREYVVDLLQGTEGRKGRFVEELLSRWQQSSQSPAEPLPAYRKKDETSESPRAGDQAKKGKRKGRNKQETPAYVEPSTHVEEVKTPLDLAKAQESSTASSSNAYKKKTKYVSLYTKEGQDRLAVLIPGRHACECLGQKHKLINNCLVCGRIVCEQEGSGPCLFCGSLVCTKEEQDILQRDSNKSQKLLKKLMAGAESSGNLDAISKDLLPRQEARLKAGLEMAVKHKDKLLEFDRTSVRRTQVIDDESDYFATDSNQWLSKQEREALQKREQELQELRHASRLAKKITIDFAGRQILEEDSGMAEYHSKLDETVEAINCGTLSQPAASPEAKMTLSSGVLVNPHLLQPAPLWVDQTGSLPLRRATHSMGAGEEFGSERNRLRIQDRELQEISDDGWCLSMHQPWASLLIRGIKRVEGRTWYTSHRGRLWIAATAKRPSPQEISELETTYRMLLRKDVEFPNEYPSGCLLGCVDVTDCLSQEQFNEQYPDLSQESGSPFVFICTNPQEMVVKFPIKGKPKIWKLDSKIHQGAKKGLMKQKAVA", "length": 682 }, "evidence": [ { "id": "F1N1K2", "url": "https://omabrowser.org/oma/group/F1N1K2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q15650-1", "protein_name": "Activating signal cointegrator 1", "gene_name": "TRIP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVAGAVSGEPLVHWCTQQLRKTFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEELITKWQKNDQELISDPLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTREGQDRLAVLLPGRHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCLFCGTLVCTHEEQDILQRDSNKSQKLLKKLMSGVENSGKVDISTKDLLPHQELRIKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKLERETLQKREEELRELRHASRLSKKVTIDFAGRKILEEENSLAEYHSRLDETIQAIANGTLNQPLTKLDRSSEEPLGVLVNPNMYQSPPQWVDHTGAASQKKAFRSSGFGLEFNSFQHQLRIQDQEFQEGFDGGWCLSVHQPWASLLVRGIKRVEGRSWYTPHRGRLWIAATAKKPSPQEVSELQATYRLLRGKDVEFPNDYPSGCLLGCVDLIDCLSQKQFKEQFPDISQESDSPFVFICKNPQEMVVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAV", "length": 581 }, "evidence": [ { "id": "F1N1K2", "url": "https://omabrowser.org/oma/group/F1N1K2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QXN3-1", "protein_name": "Activating signal cointegrator 1", "gene_name": "Trip4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVAGAAYREPLVHWCTQQLQKTFALDVSEEIIQYVLSIENAEEIREYVTDLLQGNEGKKGQFIEDLITKWQKNDQEFISDSFQQCLRKDEILDGQRSVDQLKRSRRKGRNKQEVPAFPEPDVAVEVKTPLDLAKAQESNNSVKKKTRFVNLYTREGQDKLAVLLPGRHPCDCLGQKHKLINNCLVCGRIVCEQEGSGPCLFCGSLVCTNEEQDILQRDSNKSQKLLKKLMSGAETSGKVDVSTKDLLPHQESRMKSGLEKAIKHKEKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKVEREMLQKREEELRELRHASRLSKKVTIDFAGRKILEDENPLAEYHSRLDETIQAIASGTLNQSLVTLDRSCEEPLGVLVNPNMYQASPQWVDNTGSTPQKKTSLSAGPRLEPSLHQHQLRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRSWYTPHRGRLWIAATGKRPSPQEVSELQATYRLLRGKDVEFPNDYPSGCLLGCVDLIDCLSQKQFQEQFPDISQESDSSFVFICKNPQEMVVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAV", "length": 581 }, "evidence": [ { "id": "F1N1K2", "url": "https://omabrowser.org/oma/group/F1N1K2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "estrogen receptor signaling pathway", "id": "GO:0030520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030520", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "ribosome-associated ubiquitin-dependent protein catabolic process", "id": "GO:1990116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990116", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "regulation of myoblast differentiation", "id": "GO:0045661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045661", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "RQC-trigger complex", "id": "GO:0180022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180022", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "nuclear estrogen receptor binding", "id": "GO:0030331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030331", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "ubiquitin-like protein ligase binding", "id": "GO:0044389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044389", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" }, { "name": "histone acetyltransferase binding", "id": "GO:0035035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035035", "evidence": [ { "database": "UniProtKB", "id": "F1N1K2", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1K2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1K2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1K2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K2" }, { "id": "SM01022", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ASCH", "eco_id": "ECO_0000259", "start_pos": 434, "end_pos": 549, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 218, "end_pos": 220 }, { "start_pos": 355, "end_pos": 357 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2I1-1", "uniprot_ac": "F1N2I1", "uniprot_id": "F1N2I1_BOVIN", "mass": { "chemical_mass": 79374.0, "monoisotopic_mass": 79374.0 }, "refseq": {}, "gene_names": [ { "name": "TGM6", "type": "recommended", "evidence": [ { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ] } ], "protein_names": [ { "name": "protein-glutamine gamma-glutamyltransferase", "type": "recommended", "evidence": [ { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.13", "type": "synonym", "evidence": [ { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2I1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TGM6", "url": "https://www.uniprot.org/uniprotkb/F1N2I1", "locus": { "chromosome": "13", "start_pos": 52700360, "end_pos": 52736582, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037464", "url": "https://www.ensembl.org/id/ENSBTAG00000037464" } ] } } ], "crossref": [ { "id": "F1N2I1", "url": "https://alphafold.ebi.ac.uk/entry/F1N2I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037464", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037464", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036238", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKI3", "url": "https://www.orthodb.org/?gene=A0A3Q1LKI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2I1", "url": "https://www.orthodb.org/?gene=F1N2I1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11590", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11590", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11590:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11590:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00868", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00868", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "54816", "url": "https://www.rhea-db.org/rhea/54816", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S876", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S876", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S876-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S876-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2I1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2I1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLRVTEVDWQRLRNGTAHHTQEYPGSNLVVRRGQRFTFTLELNRPLESEETLIFTVETGPQASEALHTKAVFQTSELERGDTWMAVKEAQTENTTTFSLASPPNAVIGRYQLSARVSSRRKHSDRKLGEFVLLFNPWCPEDDVFLDSEEERQEYVLNDSGIIFRGVEKRIRAQGWNFGQFEEDILNICLSILDRTPSYQDDPATDVSHRHDPVYITRAVSAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILHKWFKGRFKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTDRNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARRDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWNEDESRERVYSDTKKIGRCISTKAVGSDSRVDITSLYKYPEGSRKERQVYSKAVKKLFSVEASGRRARVRRGGGRGLWHDDLLEPATKPSITGKFKVLEPPVLGHDLKLALCLTSLTSRAQRVQVNLSGATILYTRRPVAEILHESHTVKLGPEEEKKIPIAISYSQYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAVVGVAVAVEVMVLNPLSERVKDCSLMVEGSGLLQGQLSIDVPSLDPQEKASVQFKITPFKSGPRQLQVDFVSPHFPDIKGFVIIHVATAK", "length": 706, "header": "tr|F1N2I1-1|F1N2I1_BOVIN Isoform 1 of protein-glutamine gamma-glutamyltransferase OS=Bos taurus OX=9913 GN=TGM6 PE=3 SV=3 CANONICAL=F1N2I1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKI3/entry", "sequence": { "sequence": "MAGLRVTEVDWQRLRNGTAHHTQEYPGSNLVVRRGQRFTFTLELNRPLESEETLIFTVETGPQASEALHTKAVFQTSELERGDTWMAVKEAQTENTTTFSLASPPNAVIGRYQLSARVSSRRKHSDRKLGEFVLLFNPWCPEDDVFLDSEEERQEYVLNDSGIIFRGVEKRIRAQGWNFGQVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILHKWFKGRFKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTDRNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARRDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWNEDESRERVYSDTKKIGRCISTKAVGSDSRVDITSLYKYPEGSRKERQVYSKAVKKLFSVEASGRRARVRRGGGRGLWHDDLLEPATKPSITGKFKVLEPPVLGHDLKLALCLTSLTSRAQRVQVNLSGATILYTRRPVAEILHESHTVKLGPEEEKKIPIAISYSQYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAVVGVAVAVEVMVLNPLSERVKDCSLMVEGSGLLQGQLSIDVPSLDPQEKASVQFKITPFKSGPRQLQVDFVSPHFPDIKGFVIIHVATAK", "length": 663, "header": "tr|A0A3Q1LKI3-1|F1N2I1_BOVIN Computationally mapped isoform of protein-glutamine gamma-glutamyltransferase OS=Bos taurus OX=9913 GN=TGM6 PE=3 SV=2 CANONICAL=F1N2I1-1" }, "locus": { "chromosome": "13", "start_pos": 52736463, "end_pos": 52701364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086686.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086686.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060108.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060108.2" } ] } }, { "isoform_ac": "A0AAA9S876-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S876/entry", "sequence": { "sequence": "MAGLRVTEVDWQRLRNGTAHHTQEYPGSNLVVRRGQRFTFTLELNRPLESEETLIFTVETGPQASEALHTKAVFQTSELERGDTWMAVKEAQTENTTTFSLASPPNAVIGRYQLSARVSSRRKHSDRKLGEFVLLFNPWCPEDDVFLDSEEERQEYVLNDSGIIFRGVEKRIRAQGWNFGQFEEDILNICLSILDRTPSYQDDPATDVSHRHDPVYITRAVSAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILHKWFKGRFKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTDRNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARRDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWNEDESRERVYSDTKKIGRCISTKAVGSDSRVDITSLYKYPEGSRKERQVYSKAVKKLFSVEASGRRARVRRGGGRGLWHDDLLEPATKPSITGKFKVLEPPVLGHDLKLALCLTSLTSRAQRVQVNLSGATILYTRRPVAEILHESHTVKLGPEEEKKIPIAISYSQYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKCAQPGSPREGLGPIQDHPLQERPTAAAGRLRQPPLPGHQGLCDHPRGHS", "length": 660, "header": "tr|A0AAA9S876-1|F1N2I1_BOVIN Computationally mapped isoform of protein-glutamine gamma-glutamyltransferase OS=Bos taurus OX=9913 GN=TGM6 PE=3 SV=1 CANONICAL=F1N2I1-1" }, "locus": { "chromosome": "13", "start_pos": 52736463, "end_pos": 52701368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105871.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105871.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081442.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081442.1" } ] } }, { "isoform_ac": "F1N2I1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1/entry", "sequence": { "sequence": "MAGLRVTEVDWQRLRNGTAHHTQEYPGSNLVVRRGQRFTFTLELNRPLESEETLIFTVETGPQASEALHTKAVFQTSELERGDTWMAVKEAQTENTTTFSLASPPNAVIGRYQLSARVSSRRKHSDRKLGEFVLLFNPWCPEDDVFLDSEEERQEYVLNDSGIIFRGVEKRIRAQGWNFGQFEEDILNICLSILDRTPSYQDDPATDVSHRHDPVYITRAVSAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILHKWFKGRFKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTDRNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARRDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWNEDESRERVYSDTKKIGRCISTKAVGSDSRVDITSLYKYPEGSRKERQVYSKAVKKLFSVEASGRRARVRRGGGRGLWHDDLLEPATKPSITGKFKVLEPPVLGHDLKLALCLTSLTSRAQRVQVNLSGATILYTRRPVAEILHESHTVKLGPEEEKKIPIAISYSQYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAVVGVAVAVEVMVLNPLSERVKDCSLMVEGSGLLQGQLSIDVPSLDPQEKASVQFKITPFKSGPRQLQVDFVSPHFPDIKGFVIIHVATAK", "length": 706, "header": "tr|F1N2I1-1|F1N2I1_BOVIN Isoform 1 of protein-glutamine gamma-glutamyltransferase OS=Bos taurus OX=9913 GN=TGM6 PE=3 SV=3 CANONICAL=F1N2I1-1" }, "locus": { "chromosome": "13", "start_pos": 52736463, "end_pos": 52701364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002338.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002338.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002338.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002338.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N2I1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "pmid": "" }, { "name": "protein-glutamine gamma-glutamyltransferase activity", "id": "GO:0003810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003810", "evidence": [ { "database": "UniProtKB", "id": "F1N2I1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N2I1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "peptide cross-linking", "id": "GO:0018149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018149", "evidence": [ { "database": "UniProtKB", "id": "F1N2I1", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54816", "name": "", "equation": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MI90-1", "A6QP57-1", "P12260-1", "P51176-1", "F1MBB7-1", "A0A3Q1LN92-1", "F1N2I1-1", "F1MW44-1" ], "evidence": [ { "id": "54816", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54816" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LN92", "gene_name": "TGM3", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "A0A3Q1LN92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN92" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "A0A3Q1LN92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN92" } ] } ] }, { "uniprot_ac": "A0A3Q1MI90", "gene_name": "TGM2", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "A0A3Q1MI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI90" } ] }, { "ec_number": "3.5.1.44", "activity": "L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "A0A3Q1MI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI90" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "A0A3Q1MI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI90" } ] }, { "ec_number": "3.5.1.44", "activity": "", "evidence": [ { "id": "A0A3Q1MI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI90" } ] } ] }, { "uniprot_ac": "A6QP57", "gene_name": "TGM3", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "A6QP57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP57" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "A6QP57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP57" } ] } ] }, { "uniprot_ac": "F1MBB7", "gene_name": "TGM1", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "F1MBB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBB7" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "F1MBB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBB7" } ] } ] }, { "uniprot_ac": "F1MW44", "gene_name": "F13A1", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "F1MW44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW44" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "F1MW44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW44" } ] } ] }, { "uniprot_ac": "F1N2I1", "gene_name": "TGM6", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ] } ] }, { "uniprot_ac": "P12260", "gene_name": "F13A1", "activity": [ { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "P12260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P12260" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "P12260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P12260" } ] } ] }, { "uniprot_ac": "P51176", "gene_name": "TGM2", "activity": [ { "ec_number": "3.4.-.-", "activity": "", "evidence": [ { "id": "P51176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51176" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P51176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51176" } ] }, { "ec_number": "2.3.2.13", "activity": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "P51176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51176" } ] }, { "ec_number": "3.5.1.44", "activity": "L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "P51176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51176" } ] }, { "ec_number": "2.3.2.13", "activity": "", "evidence": [ { "id": "P51176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P51176" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2I1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 706, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2I1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2I1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" }, { "id": "SM00460", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00460" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transglutaminase-like", "eco_id": "ECO_0000259", "start_pos": 266, "end_pos": 359, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" } ], "binding_site_uniprot": 353, "amino_acid": "Gln", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 353, "end_pos": 353, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" } ], "binding_site_uniprot": 355, "amino_acid": "Leu", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 355, "end_pos": 355, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" }, { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "binding_site_uniprot": 396, "amino_acid": "Asn", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 396, "end_pos": 396, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" }, { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "binding_site_uniprot": 398, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 398, "end_pos": 398, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" } ], "binding_site_uniprot": 402, "amino_acid": "Trp", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 402, "end_pos": 402, "start_aa": "Trp", "end_aa": "Trp", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" } ], "binding_site_uniprot": 407, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 407, "end_pos": 407, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" }, { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "binding_site_uniprot": 445, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 445, "end_pos": 445, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR000459-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000459-2" }, { "id": "F1N2I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2I1" } ], "binding_site_uniprot": 450, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 450, "end_pos": 450, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.13", "ec_name": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+).", "evidence": [ { "id": "2.3.2.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13" }, { "id": "2.3.2.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.13" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 16, "end_pos": 18 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 530, "end_pos": 532 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N531-1", "uniprot_ac": "F1N531", "uniprot_id": "F1N531_BOVIN", "mass": { "chemical_mass": 65945.0, "monoisotopic_mass": 65945.0 }, "refseq": {}, "gene_names": [ { "name": "JMJD4", "type": "recommended", "evidence": [ { "id": "F1N531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ] } ], "protein_names": [ { "name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "type": "recommended", "evidence": [ { "id": "F1N531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N531/entry#names_and_taxonomy" } ] }, { "name": "JmjC domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "F1N531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N531/entry#names_and_taxonomy" } ] }, { "name": "Jumonji domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "F1N531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N531/entry#names_and_taxonomy" } ] }, { "name": "Lysyl-hydroxylase JMJD4", "type": "synonym", "evidence": [ { "id": "F1N531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N531/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JMJD4", "url": "https://www.uniprot.org/uniprotkb/F1N531", "locus": { "chromosome": "7", "start_pos": 3474795, "end_pos": 3469253, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004191", "url": "https://www.ensembl.org/id/ENSBTAG00000004191" } ] } } ], "crossref": [ { "id": "F1N531", "url": "https://alphafold.ebi.ac.uk/entry/F1N531", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004191", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004191", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506151", "url": "https://www.ncbi.nlm.nih.gov/gene/506151", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506151", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506151", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HPCMFSR", "url": "https://omabrowser.org/oma/group/HPCMFSR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N531", "url": "https://www.orthodb.org/?gene=F1N531", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12480", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12480", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12480:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12480:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9629569", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629569", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "57156", "url": "https://www.rhea-db.org/rhea/57156", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N531-1", "url": "https://www.uniprot.org/uniprotkb/F1N531-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRACAQGLALRVSGSGRNSECRLLVPLDCSGTTSGSAVCTSPVSLWPAVGCEPRTPRGFTPEAVLANTSFFFSQFKEQRRRNAQVGFRASALRGSAAGRLHRCFHYPYQPLCPRCSFDIPRAPPRSQQPSRLPVPPRQTPSPGFPAPHGRRTWPGMDRETRVFAESHFRGLEGRLPSRVCPKLDRVDFIEKPDSFSYADFFKGYLLPNLPCVFSSAFTEDWGSRRLWVTPSGKPNFDYLLQNYGDVVVPVANCGVQEYNSNPKEHMPLRDYISYWKEYIQANYSSSRGCLYLKDWHLCRDFLAEGVFTLPIYFSSDWLNEYWDALDVDDYRFVYMGPTGTWSPFHADVFRSFSWSVNICGRKKWFFFPPGQEEALRDCHGGLPYDVTSPTLLDSRLHPMRDRCGPPLEVTQEAGEMVFVPSGWHHQVHNLEDTISINHNWVNGCNLANMWHFLQQELSAVQQEVIEWRDTMPDWHHHCQVIMKSCSGINFEEFYHFLKIIAERRLLLLAKGMSPGQVEGGEDTGLGPQQAAFDIGRIAEVLESVVAHPDFQRVDPSTFSPRPEVLLRQLEEAVAATTSL", "length": 580, "header": "tr|F1N531-1|F1N531_BOVIN Isoform 1 of 2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Bos taurus OX=9913 GN=JMJD4 PE=3 SV=3 CANONICAL=F1N531-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKP7/entry", "sequence": { "sequence": "MKRACAQGLALRVSGSGRNSECRLLVPLDCSGTTSGSAVCTSPVSLWPAVGCEPRTPRGFTPEAVLANTSFFFSQFKEQRRRNAQVGFRASALRGSAAGRLHRCFHYPYQPLCPRCSFDIPRAPPRSQQPSRLPVPPRQTPSPGFPAPHGRRTWPGMDRETRVFAESHFRGLEGRLPSRVCPKLDRVDFIEKPDSFSYADFFKGYLLPNLPCVFSSAFTEDWGSRRLWVTPSGKPNFDYLLQNYGDVVVPVANCGVQEYNSNPKEHMPLRDYISYWKEYIQANYSSSRGCLYLKDWHLCRSPFHADVFRSFSWSVNICGRKKWFFFPPGQEEALRDCHGGLPYDVTSPTLLDSRLHPMRDRCGPPLEVTQEAGEMVFVPSGWHHQVHNLEDTISINHNWVNGCNLANMWHFLQQELSAVQQEVIEWRDTMPDWHHHCQVIMKSCSGINFEEFYHFLKIIAERRLLLLAKGMSPGQVEGGEDTGLGPQQAAFDIGRIAEVLESVVAHPDFQRVDPSTFSPRPEVLLRQLEEAVAATTSL", "length": 538, "header": "tr|A0A3Q1LKP7-1|F1N531_BOVIN Computationally mapped isoform of 2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Bos taurus OX=9913 GN=JMJD4 PE=3 SV=1 CANONICAL=F1N531-1" }, "locus": { "chromosome": "7", "start_pos": 3474668, "end_pos": 3469380, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074631.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074631.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057295.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057295.1" } ] } }, { "isoform_ac": "F1N531-1", "url": "https://www.uniprot.org/uniprotkb/F1N531/entry", "sequence": { "sequence": "MKRACAQGLALRVSGSGRNSECRLLVPLDCSGTTSGSAVCTSPVSLWPAVGCEPRTPRGFTPEAVLANTSFFFSQFKEQRRRNAQVGFRASALRGSAAGRLHRCFHYPYQPLCPRCSFDIPRAPPRSQQPSRLPVPPRQTPSPGFPAPHGRRTWPGMDRETRVFAESHFRGLEGRLPSRVCPKLDRVDFIEKPDSFSYADFFKGYLLPNLPCVFSSAFTEDWGSRRLWVTPSGKPNFDYLLQNYGDVVVPVANCGVQEYNSNPKEHMPLRDYISYWKEYIQANYSSSRGCLYLKDWHLCRDFLAEGVFTLPIYFSSDWLNEYWDALDVDDYRFVYMGPTGTWSPFHADVFRSFSWSVNICGRKKWFFFPPGQEEALRDCHGGLPYDVTSPTLLDSRLHPMRDRCGPPLEVTQEAGEMVFVPSGWHHQVHNLEDTISINHNWVNGCNLANMWHFLQQELSAVQQEVIEWRDTMPDWHHHCQVIMKSCSGINFEEFYHFLKIIAERRLLLLAKGMSPGQVEGGEDTGLGPQQAAFDIGRIAEVLESVVAHPDFQRVDPSTFSPRPEVLLRQLEEAVAATTSL", "length": 580, "header": "tr|F1N531-1|F1N531_BOVIN Isoform 1 of 2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Bos taurus OX=9913 GN=JMJD4 PE=3 SV=3 CANONICAL=F1N531-1" }, "locus": { "chromosome": "7", "start_pos": 3474668, "end_pos": 3469380, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005487.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005487.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005487.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005487.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506151", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506151", "resource": "KEGG Pathway" }, { "id": "R-BTA-9629569", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629569", "resource": "Reactome", "description": "Protein hydroxylation" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A029-1", "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "Jmjd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDRETRTFAERYYRGLRDRVPSGGGPRPSSVNFIQAPDAFSYADFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPDFEYLLQKYGDAVVPVANCGVREYNSNPKEHMPFRDYISYWKEYIQGGYSSPRGCLYLKDWHLCRDSLVDDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPKGTCPCCRSPFHADIFRSFSWSVNICGKKKWLFFPPGQEEALRDCRGNLPYDVTSTELLDTHLYPRIQQDSLPIEVIQEPGEMVFVPSGWHHQVYNLEDTISINHNWVNGCNLANMWHFLQQELQAVQHEVGEWKDSMPDWHHHCQVIMKSCTGINYEEFYHFLKVIAEKRLLVLRQGLKGDSGDNKSLGLGLQQAAFDVGRLADVLASVVVNPDFQRVDTSVFSPQPEELLQQLEDSVTAAEAL", "length": 430 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NX61-1", "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "JMJD4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDRATFACSTAFFHDYSSSAQGTFSTGHVDFIDKIESFTYSDFFRDYLIPNQPCVFSEKFTDGWGSRRNWVTWGGKPDFDHLLQEFGEAIVPVANCDVKEYNSNPKEQLPFKEYISYWKEYIKNGYRSSRGCLYLKDWHLSRAFPEQDVYTTPVYFSSDWLNEYWDAIAVDDYRFVYMGPKGSWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDYLKDCHGNLPFDVTAPGLQDRSVYPRYNQSQPPVEIVQEAGEIVFIPSGWHHQVYNLEDTISINHNWVNGCNVAIMWCFLQDELAAVQREINEWKDPMDDWHLQCQLIMKSCTGIDYKEFYNFLKVIAENRISILENGLDDEASAKNTPKAAISTLGMLHAVFDLKRTVKVLTSLSANEDFKKLDLTSLSPPPEALLHHLKAAIDTALL", "length": 425 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S5T5-1", "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "JMJD4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRQMRAFAESHFRGLQGGLSSNVSPKLDHVDFIENPDSFSYADFFKGYLLPNLPCVFSSAFTEGWGSRRLWVTPSGKPNFDYLLQNYGDVVVPVANCGVREYNSNPKEHMPLKDYISYWKEYIQGNYSSSRGCLYLKDWHLCRDSSAESVFTLPIYFSSDWLNEYWDALDVDDYRFIYMGPTGTWSPFHADIFRSFSWSVNICGRKKWFFFPPGQEEALRDCHGGLPYDVTSPTLLDSRLHPVLNRCSPPLEVTQEAGEMVFVPSGWHHQVHNLEDTISINHNWVNGCNLANMWHFLQQELCAVQQEIIEWRDTMPDWHHHCQVIMRSCSGINFEEFYHFLKVIAERRLLFLAKGVGPGKVECGKSTGLGPQQAAFDVSRIAEVLKSVLAHPDFQRMDTSTFSPQPEELLQQLEEVVAATTSL", "length": 424 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08BY5-1", "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "jmjd4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDRETFHSCSSLVKLPRQIHQQHCSSHFIEYIEREIPYSKFFKNYLIPNQPCMFSKKFTEEWNCRKKWVTAEGKPNLQRLLHEFDETPVPVANCSVKEYNANPKQIMPFKEFIQYWRESIQNGHSSPKGCLYLKDWHMQRNFPEHNIYKTPIYFSSDWLNEYWDTIEVDDYRFVYMGPKGSWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDFLRDCHGNLAYDVTAPILQDKGLYAQFEEACQPLEIIQEAGEIIFVPSGWHHQVYNLEDTISINHNWLNGCNLDIMWQFLQDELSSVQREIEEWRDTMDTWHQHCQVIMKSCTGIDYAEFASFLKTIANNRISFLNSSPRNADSCQDLLAESLCALGPHHAAFDLQRVLHIFEIMLNNEDFKRLDPATLSFKPEDLLQEIREAIRTIV", "length": 422 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q67ZB6-1", "protein_name": "Arginine-specific demethylase JMJ20", "gene_name": "JMJ20", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGIQIIGQIERINGKELSYGDFAERYLAKNQPVVISDLTEDWRAREDWVSENGNPNLHVFATHFGKSRVQVADCDTREFTDQKRLEMSVTEFVEQWTNKDSIEESVLYLKDWHFVKEYPDYTAYQTPPLFSDDWLNVYLDNYQMHEDRDSFQKYDQISCSDYRFVYMGGKGSWTPLHADVFRSYSWSANVCGKKRWLFLPPPQSHLVYDRYMKNCVYDIFEEVNETKFPGFKKTTWLECIQEPGEIIFVPSGWHHQVYNLEDTISINHNWLNAYNLSWVWDLLWKDYKDTEESIEDIRDICDDFEAICQRNLAANTGMNLNDFFLFMSRFSLGNMVLLQSYSDKHKNLNSCSLAMAQNLLMNLSTILKVMMKMISAGGVTAEEVYLDLRETLEDPQFLRFVRDMGRTYARIHMEEEDQFLSSKELLQKLSGLAGPNMQICSPKDLVEMINHHNTFSSQIYFI", "length": 462 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8BFT6-1", "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "Jmjd4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRETRTFAERYYRDLRDPVPSGGGGPTPSGVTFIQTPNAFSYADFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPDFEYLQQKYGDAVVPVANCGVREYNSNPKEHMSFRDYISYWKDYIQGSYSSSRGCLYLKDWHLCRDSLVNDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPRGTWSPFHADIFRSFSWSVNICGKKKWLFFPPGEEEALRDCHGNLPYDVTSTELLDTHLYPKIQHHSLPIEVIQEPGEMVFVPSGWHHQVYNLDDTISINHNWVNGCNLPNMWHFLQQELQAVQHEVEEWKDSMPDWHHHCQVIMKSCTGINFEEFYHFLKVIAEKRLLVLEQGLKGDSGDSRSLDLGLQQAAFDIGRLADVLASVVVNPDFQRVDTSAFSPQPEELLQQLEDAVAAAEAL", "length": 427 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H9V9-3", "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "JMJD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRETRALADSHFRGLGVDVPGVGQAPGRVAFVSEPGAFSYADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQAGYSSPRGCLYLKDWHLCRDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKKWLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVHNLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINFEEFYHFLKVIAEKRLLVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQRVDTSAFSPQPKELLQQLREAVDAAAAP", "length": 417 }, "evidence": [ { "id": "F1N531", "url": "https://omabrowser.org/oma/group/F1N531/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" }, { "name": "2-oxoglutarate-dependent dioxygenase activity", "id": "GO:0016706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" }, { "name": "catalytic activity, acting on a protein", "id": "GO:0140096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140096", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of translational termination", "id": "GO:0045905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045905", "evidence": [ { "database": "UniProtKB", "id": "F1N531", "url": "https://www.uniprot.org/uniprotkb/F1N531" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "57156", "name": "", "equation": "L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "57156", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/57156" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N531-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 580, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N531-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N531" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N531" }, { "id": "PS51184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "JmjC", "eco_id": "ECO_0000259", "start_pos": 299, "end_pos": 458, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1Z3-1", "uniprot_ac": "F1N1Z3", "uniprot_id": "F1N1Z3_BOVIN", "mass": { "chemical_mass": 66662.0, "monoisotopic_mass": 66662.0 }, "refseq": { "ac": "XP_024838090", "name": "CREB-regulated transcription coactivator 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838090" }, "gene_names": [ { "name": "CRTC3", "type": "recommended", "evidence": [ { "id": "F1N1Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ] }, { "name": "CRTC3", "type": "synonym", "evidence": [ { "id": "XP_024838090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838090" } ] } ], "protein_names": [ { "name": "CREB regulated transcription coactivator 3", "type": "synonym", "evidence": [ { "id": "F1N1Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3/entry#names_and_taxonomy" } ] }, { "name": "CREB-regulated transcription coactivator 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838090", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838090" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRTC3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3", "locus": { "chromosome": "21", "start_pos": 21992224, "end_pos": 22086270, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010915", "url": "https://www.ensembl.org/id/ENSBTAG00000010915" } ] } } ], "crossref": [ { "id": "F1N1Z3", "url": "https://alphafold.ebi.ac.uk/entry/F1N1Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010915", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010915", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540109", "url": "https://www.ncbi.nlm.nih.gov/gene/540109", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540109", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540109", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LPHNGQN", "url": "https://omabrowser.org/oma/group/LPHNGQN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLZ8", "url": "https://www.orthodb.org/?gene=A0A3Q1LLZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1Z3", "url": "https://www.orthodb.org/?gene=F1N1Z3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13589", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13589", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13589:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13589:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838090", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838090", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Z3-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSAPEFQPVFHPADSVRGTRHHGLVERPSRTRFHPLHRRSGDKPGRQFDGSTLGANYASQPLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPASYVGFCDGENDVHGEVVSFPGPLREENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGSTFPHNGQNMGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTGDHLFGSMSVGNSVGNLPAAMTHLGIRGSSGLQSSRSNPSIQATLNKTVLSSSLNSRPEASAASASALHPSLRLFSLSNPSLSTTSLSGPPRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLHPYPASQMVSSDRSPLSFLPTEAQAQVSPPPPYPAAHDLPQPLLQQPHAQEPPAQQPQAASSLSQSDFPLLTAQGSSLTSFFPDVSFDQQSMRPGPAFTQQVPPVQQGPREPQDSFHLRPNLYSNCGNFPNTVLTEDSSTSLFKDLSSALGGMPEVSLSVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 619, "header": "tr|F1N1Z3-1|F1N1Z3_BOVIN Isoform 1 of CREB regulated transcription coactivator 3 OS=Bos taurus OX=9913 GN=CRTC3 PE=3 SV=3 CANONICAL=F1N1Z3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLZ8/entry", "sequence": { "sequence": "MVQFQKLQQLRLTQYHGGSLPNVSQLRSSAPEFQPVFHPADSVRGTRHHGLVERPSRTRFHPLHRRSGDKPGRQFDGSTLGANYASQPLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPASYVGFCDGENDVHGEVVSFPGPLREENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGSTFPHNGQNMGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTGDHLFGSMSVGNSVGNLPAAMTHLGIRGSSGLQSSRSNPSIQATLNKTVLSSSLNSRPEASAASASALHPSLRLFSLSNPSLSTTSLSGPPRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLHPYPASQMVSSDRSPLSFLPTEAQAQVSPPPPYPAAHDLPQPLLQQPHAQEPPAQQPQAASSLSQSDFPLLTAQGSSLTSFFPDVSFDQQSMRPGPAFTQQVPPVQQGPREPQDSFHLRPNLYSNCGNFPNTVLTEDSSTSLFKDLSSALGGMPEVSLSVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 576, "header": "tr|A0A3Q1LLZ8-1|F1N1Z3_BOVIN Computationally mapped isoform of CREB regulated transcription coactivator 3 OS=Bos taurus OX=9913 GN=CRTC3 PE=3 SV=1 CANONICAL=F1N1Z3-1" }, "locus": { "chromosome": "21", "start_pos": 22086226, "end_pos": 21993228, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076080.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076080.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060870.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060870.1" } ] } }, { "isoform_ac": "F1N1Z3-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3/entry", "sequence": { "sequence": "MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSAPEFQPVFHPADSVRGTRHHGLVERPSRTRFHPLHRRSGDKPGRQFDGSTLGANYASQPLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPASYVGFCDGENDVHGEVVSFPGPLREENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGSTFPHNGQNMGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTGDHLFGSMSVGNSVGNLPAAMTHLGIRGSSGLQSSRSNPSIQATLNKTVLSSSLNSRPEASAASASALHPSLRLFSLSNPSLSTTSLSGPPRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLHPYPASQMVSSDRSPLSFLPTEAQAQVSPPPPYPAAHDLPQPLLQQPHAQEPPAQQPQAASSLSQSDFPLLTAQGSSLTSFFPDVSFDQQSMRPGPAFTQQVPPVQQGPREPQDSFHLRPNLYSNCGNFPNTVLTEDSSTSLFKDLSSALGGMPEVSLSVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 619, "header": "tr|F1N1Z3-1|F1N1Z3_BOVIN Isoform 1 of CREB regulated transcription coactivator 3 OS=Bos taurus OX=9913 GN=CRTC3 PE=3 SV=3 CANONICAL=F1N1Z3-1" }, "locus": { "chromosome": "21", "start_pos": 22085854, "end_pos": 21993228, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014501.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014501.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014501.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014501.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540109", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540109", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZST9-1", "protein_name": "CREB regulated transcription coactivator 3", "gene_name": "CRTC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSAPDFQPAFHPADSVRGTRHHGLVERPSRTRFHPLHRRSGDKPGRQFDGSAFGATYASQPLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKAQDPYGGGGQSAWPASYMGFCDGENDVHGEGVSFPSPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGSAFPHNGQNIGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTSDHLFGSMSVGNSVGNLPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTALSSSLNSHPQASAPSASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLNPYPASQMASSDRSPLSFLPTEAQAQVSPPPPYPTPQDLPQPLLQQPRAQEPPAQQPQAASSLPQSDFQLLPAQGSSLTSFFPDVSFDQPSMRPGPAFTQQVPLVQQGAREPQDSFHLRPNLYSNCGNFPNTSLTEDSSTSLFKDLSSALAGMPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 619 }, "evidence": [ { "id": "F1N1Z3", "url": "https://omabrowser.org/oma/group/F1N1Z3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1LVL6-1", "protein_name": "CREB regulated transcription coactivator 3", "gene_name": "Crtc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQRLQQLRLTQHHGGSLPNVSQLRGSAPELQPSLHHADNVRGTRHHGLVERPARNRFHPLHRRSGDKPGRQFDGNAFAASYSSQPLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMAAFPGLLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGSAFPHNGQNTGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTSDHLFGSMSVGNSVGNLPAAMTHLGIRNSSGLQSSRSNPSIQATLNKIALSSSLNSHPQPSVANASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFNRQLSATSPLNPYPASQMVTSEQSPLSFLPTDAQAQVSPPPPYPTPQELPQPLLQQPHAHEPPAQQPQAAPSLSQSDFQLLTAQGSSLTNFFRDVGFDQQPMRPSPAFPQQVPLVQQSHREPQDSFHLRPNPYSNCGSFPNTILTEDTNTSLFKGLSGGLSGMPEVSLDMDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 606 }, "evidence": [ { "id": "F1N1Z3", "url": "https://omabrowser.org/oma/group/F1N1Z3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UUV7-1", "protein_name": "CREB-regulated transcription coactivator 3", "gene_name": "CRTC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSASEFQPSFHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCGSLPNTILPEDSSTSLFKDLNSALAGLPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 619 }, "evidence": [ { "id": "F1N1Z3", "url": "https://omabrowser.org/oma/group/F1N1Z3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91X84-1", "protein_name": "CREB-regulated transcription coactivator 3", "gene_name": "Crtc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRNSAPEFQPSLHQADNVRGTRHHGLVERPARNRFHPLHRRSGDKPGRQFDGNAFAASYSSQHLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENDGHAEVAAFPGPLKEENLLNVPKPLPKHLWESKEIQSLSGRPRSCDVGGGNAFPHNGQNTGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTSDHLFGSMSVGNSVGNLPAAMTHLGIRTSSGLQSSRSNPSIQATLSKMALSSSLKCHPQPSVANASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSATSPLNPYPASQMVTSEQSPLSFLPTDAQAQVSPPPPYPTPQELPQPLLQQPHAQEPPTQQPQAAPSLPQSDFQLLTAQGSALTSFFPDVRFDQQPMRPSPAFPQQVPLVQQSHREPQDSFHLRPNPYSSCGSFPGTILTEDTNSNLFKGLSGGLSGMPEVSLDMDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL", "length": 619 }, "evidence": [ { "id": "F1N1Z3", "url": "https://omabrowser.org/oma/group/F1N1Z3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "cAMP response element binding protein binding", "id": "GO:0008140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008140", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway", "id": "GO:0071878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071878", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" }, { "name": "macrophage activation", "id": "GO:0042116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042116", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z3", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1Z3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 619, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1Z3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1Z3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" }, { "id": "PF12886", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12886" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transducer of regulated CREB activity C-terminal", "eco_id": "ECO_0000259", "start_pos": 545, "end_pos": 619, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" }, { "id": "PF12884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transducer of regulated CREB activity N-terminal", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 64, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z3" }, { "id": "PF12885", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12885" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transducer of regulated CREB activity middle", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 321, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1Q7-1", "uniprot_ac": "F1N1Q7", "uniprot_id": "F1N1Q7_BOVIN", "mass": { "chemical_mass": 185300.0, "monoisotopic_mass": 185300.0 }, "refseq": { "ac": "XP_024857071", "name": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857071" }, "gene_names": [ { "name": "PREX1", "type": "recommended", "evidence": [ { "id": "F1N1Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ] }, { "name": "PREX1", "type": "synonym", "evidence": [ { "id": "XP_024857071", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857071" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "type": "recommended", "evidence": [ { "id": "F1N1Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024857071", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857071" } ] } ], "function": [ { "annotation": "Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LME9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LME9#function" }, { "database": "UniProtKB", "id": "ARBA00055300", "url": "https://www.uniprot.org/uniprotkb/ARBA00055300#function" }, { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PREX1", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7", "locus": { "chromosome": "13", "start_pos": 76841311, "end_pos": 77021835, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015609", "url": "https://www.ensembl.org/id/ENSBTAG00000015609" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015609", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015609", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527410", "url": "https://www.ncbi.nlm.nih.gov/gene/527410", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527410", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527410", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TMPHYEF", "url": "https://omabrowser.org/oma/group/TMPHYEF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LME9", "url": "https://www.orthodb.org/?gene=A0A3Q1LME9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1Q7", "url": "https://www.orthodb.org/?gene=F1N1Q7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013406", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024857071", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857071", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LME9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LME9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LME9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LME9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Q7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVSGGRDPGGDGAGDSAPPDALAHGAAAPNSGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNAADSVEKGLTEENVKILFSNIEDILEVHKDFLEALEFCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGGKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEMAGLQVGRKIFSINEDLVFLRPLAEVESILNQSFCSRHPLRLLVATKAKEIVKVPDHPEALCFQIRGAAPPYVYAVGRGSEAAAAGLCAGQCILKVNGNNVTNDGASEVLEHFQAFRSRQEEALGLYQWIYRTHEDAQEAREAAGEDPSGEGAGEEDQLNSAFPLMSLGAQPSQHEDSPLVSLTVDNVHLEHGVVYEYVSTAGVKCHVLEKIVEPRGCFSLTAKILEAFAADDSVFVQNCGRLMALSSNMRTMSHFEFRNICDTKLESIGQRIACYQEFAAQLKSRISPPFKQAPLEPHPLCGLDFCPTNCHVNLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAADGDPQRQGPNDSSFGPANGALGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPSSSGSCDPAVAEEASSPPLVSEESEMDRTDHGASKKVCFKVCEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHTLLKGPVMSRAFEETKHFPMDHSLQEFKQKEECTIRGRNLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDGIFCQALVAAVCAFSEQLLAALSYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPAVKEERTMLEDIWVTLSELDNVTFSFKQLDENCVANTNVFYHIEGSRQALKVVLYLDSYHFSKLPSRLESGASLRLHTVLFTKALESMEVSPPPGSQAVEDLQQEINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSLVHPKPGAAGSLGAGLIPISSELCYRLGACQIAMCATGMQRSTLSLSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQVPQGAPRLYRLCQPPVDGDL", "length": 1653, "header": "tr|F1N1Q7-1|F1N1Q7_BOVIN Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein OS=Bos taurus OX=9913 GN=PREX1 PE=4 SV=3 CANONICAL=F1N1Q7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LME9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LME9/entry", "sequence": { "sequence": "MKDKFCVYEEYCSNHEKALRLLVELNKIPAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGGKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEMAGLQVGRKIFSINEDLVFLRPLAEVESILNQSFCSRHPLRLLVATKAKEIVKVPDHPEALCFQIRGAAPPYVYAVGRGSEAAAAGLCAGQCILKVNGNNVTNDGASEVLEHFQAFRSRQEEALGLYQWIYRTHEDAQEAREAAGEDPSGEGAGEEDQLNSAFPLMSLGAQPSQHEDSPLVSLTVDNVHLEHGVVYEYVSTAGVKCHVLEKIVEPRGCFSLTAKILEAFAADDSVFVQNCGRLMALSSNMRTMSHFEFRNICDTKLESIGQRIACYQEFAAQLKSRISPPFKQAPLEPHPLCGLDFCPTNCHVNLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAADGDPQRQGPNDSSFGPANGALGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPSSSGSCDPAVAEEASSPPLVSEESEMDRTDHGASKKVCFKVCEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHTLLKGPVMSRAFEETKHFPMDHSLQEFKQKEECTIRGRNLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDGIFCQALVAAVCAFSEQLLAALSYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPAVKEERTMLEDIWVTLSELDNVTFSFKQLDENCVANTNVFYHIEGSRQALKVVLYLDSYHFSKLPSRLESGASLRLHTVLFTKALESMEVSPPPGSQAVEDLQQEINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSLVHPKPGAAGSLGAGLIPISSELCYRLGACQIAMCATGMQRSTLSLSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQVPQGAPRLYRLCQPPVDGDL", "length": 1518, "header": "tr|A0A3Q1LME9-1|F1N1Q7_BOVIN Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein OS=Bos taurus OX=9913 GN=PREX1 PE=4 SV=2 CANONICAL=F1N1Q7-1" }, "locus": { "chromosome": "13", "start_pos": 76940150, "end_pos": 76842315, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074728.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074728.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057848.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057848.2" } ] } }, { "isoform_ac": "F1N1Q7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7/entry", "sequence": { "sequence": "MEVSGGRDPGGDGAGDSAPPDALAHGAAAPNSGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNAADSVEKGLTEENVKILFSNIEDILEVHKDFLEALEFCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGGKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEMAGLQVGRKIFSINEDLVFLRPLAEVESILNQSFCSRHPLRLLVATKAKEIVKVPDHPEALCFQIRGAAPPYVYAVGRGSEAAAAGLCAGQCILKVNGNNVTNDGASEVLEHFQAFRSRQEEALGLYQWIYRTHEDAQEAREAAGEDPSGEGAGEEDQLNSAFPLMSLGAQPSQHEDSPLVSLTVDNVHLEHGVVYEYVSTAGVKCHVLEKIVEPRGCFSLTAKILEAFAADDSVFVQNCGRLMALSSNMRTMSHFEFRNICDTKLESIGQRIACYQEFAAQLKSRISPPFKQAPLEPHPLCGLDFCPTNCHVNLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAADGDPQRQGPNDSSFGPANGALGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPSSSGSCDPAVAEEASSPPLVSEESEMDRTDHGASKKVCFKVCEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHTLLKGPVMSRAFEETKHFPMDHSLQEFKQKEECTIRGRNLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDGIFCQALVAAVCAFSEQLLAALSYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPAVKEERTMLEDIWVTLSELDNVTFSFKQLDENCVANTNVFYHIEGSRQALKVVLYLDSYHFSKLPSRLESGASLRLHTVLFTKALESMEVSPPPGSQAVEDLQQEINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSLVHPKPGAAGSLGAGLIPISSELCYRLGACQIAMCATGMQRSTLSLSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQVPQGAPRLYRLCQPPVDGDL", "length": 1653, "header": "tr|F1N1Q7-1|F1N1Q7_BOVIN Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein OS=Bos taurus OX=9913 GN=PREX1 PE=4 SV=3 CANONICAL=F1N1Q7-1" }, "locus": { "chromosome": "13", "start_pos": 77021636, "end_pos": 76842315, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043215.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043215.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040802.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040802.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527410", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527410", "resource": "KEGG Pathway" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013406", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9013409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013409", "resource": "Reactome", "description": "RHOJ GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GLR6-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "gene_name": "Prex1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAPGSGSGDGGGDPGGDGAHPDARGPSSGPCAAARDSERQLRLRLCVLNEILATERDYVGTLRFLQSAFLQRIRQNVADSVDKGLTEENVKILFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAARAFLLNCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELSKRTPGKHPDHSAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETILNQSFCSRRPLRLLVATKAKETIKIPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGLCAGQCILKVNGNSVANDGALEVLEHFQAFRSRREEALGLYQWVYHSHEDAQQARASQGAPDEDPQEDDSVLPLLSLGPQLSLHEDSAVVSLTLDNVHLEHGVVYEYVSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAEDDSLFVQNCGRLMAMGSAIITMSHYEFHNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEDHPLCGLDFCPTNCHINFMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMAYTQHCITTMAAPSWKCAPAVDGDSQSQGLIDSIFVSASGALSQQERGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSAAPCDPPLVEETSSSPPASEESEVDRTDHGGIKKVCFKVSEDEQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDETGSGDELPCDIRIPSDKQDKLHGCLEHLFNQVDSIHALLKGPVMSRAFEETRHFPMEHSWQEFKQKEECTVRGRNLIQISIQEDPWNLPSSIRTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVAAVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENSVANTNVFYHIEGSRQALKVVFYLDGFHFSRLPSRLEGGASLRLHTVLFTKALENVEGPSPPGSQAAEDLQQEINAQSLEKVQQYYRRLRAFYLERSNLPTDATTTAVKIDQLIRPINALDELYRLMKSFVHPKAGAGGSLGAGLVPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQGPRVEILAKNLRIKDPMPQGAPRLYRLCQPPVDGDL", "length": 1646 }, "evidence": [ { "id": "F1N1Q7", "url": "https://omabrowser.org/oma/group/F1N1Q7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0AC58G9V8-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1", "gene_name": "prex1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSHSYEMLGAERLLWGCGQALMADCHAEDASPQGHTRLFINLGSPQQNEPPTYPAYVFCNGCPSSCNPSLAFLQRIRQTAENQQCLTQEQVKVLFSNIESILDVHREFLSTLDASLQPEPQAHHSLGHVFLQFKVRFSVYGEYCSNHEKALRLLMELNKIPHIRAFLLHLMLLGGKKSTDVPLEGYLLSPIQRICKYPLLLRELLKRTPKKHSDYPAVEEALQAMKAVCCNINETKRQMEKLEALEILQSHIEGWEGTNLTDICTELLLQGNLLKISAGNIQERVFFLFDNLLVYCKRKSRVSGKKSTKRTKSINGPQYVFRGRINTEVMEVENVEDGTADYHSNNYTVTNGWKIHNTAKNKWFVCMAKNAEDKQKWLDAILKEREQRESLKLGMERDAYVMIAEKGEKLYHMMMTKNRHLIKDRRRKLTNVPKCFLGNEFVSWLLESGEISKAEEGINLGQALLENGIIHHVSDKHQFKNEQVLYRFRYDDGTYKARSEMEDIISKGVRLYCRLHSLFTPVVKDRDHHLKTFKSVIPASKLVEWLVSQGDSASREDAVTLGVGLCNAGFMHHVLEKSEFKDESQFFRFYADEETEGTSSKSKQLRSDFKLIENILAKSLVIHPEEEDYGFEIEEKNKAIIVKSVSRGSYAEMAGLQPGRKIYSINEDLVFLRPFSEVETMINQSFCIRRSLRLLVATKNKEIVKIPDVHGTLPFVLSGSCPPHIHAVKKGSEAAAAGLQPGQCVLKVNGNNMNQSGYQEVLEHFSGYQPVLEQQDTSCGQWAYRVYEDVEEQMSFRGCENGSDSEDGCTNGTGSVRRLEQLSISDDGPLVSLNVDNVHVEHGVVYEYVSPAGIKHCVLEKMVEPKGCFNLTAKILKAFVKDDSLFVKSCRQLMALNDKVVTMPQFEFRNICDTKLESIDKRISSYKQFVEELQTKAWPTFKQASTKPHILGCMDFVPTNCHLNLMQVSCPKNTSSAGRAFSIRFGRKNSFFGLDPDQANLNPMSHSVHCVTSMGAPSFSCQSLDEETENGEGNSEDSRKHEEGGLSFLLKQEDTESQDNYICLYNRLDIAVREMKQYVAQIDVLLSSITGPTQPQGSEPPSFESGPSTSPIPEETDQDKTEHCGNKRVCFKVNEDDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMQIPFDKQDKLHGCLEHLFNQVDSINSLLKGPVMSKACEETKHFHTDHSQPEFRHTDDWTVRWRYVLHKNIQEDPWNLPISIKSLINSLHRFVEDGRSQLLLALLKCTDTKLQLRRDVIFCQSLVGALCALAEQLVTALNLRFNNNGEYEEDSKEVSHKWLEQISTIGVLFNFQSTLSPHVREERIMLEDTKAALQDLEKVTVLFRPLENECLVPNTSVHYQVEGSRQAIRVTMFLDNCHFSELPTRLQNGGSLKLQSVLFTRGLEKPEGVLSQDFVTMEEFQQRTNALSLEKVKGYYRKLRAFYLEKSNSDSNSTAMKIDQLLRPLNTLDDLCRLMQTYMNVKASSAGQPSGVSVLLVSSELCNRLGACQITMCATGMQRCTLTVSLEQATILARNHSLMPRCLMQTMDLMRKQGTRVEISAKNLRVMDQMPPLAPRLFRLCLPPSDGDL", "length": 1640 }, "evidence": [ { "id": "F1N1Q7", "url": "https://omabrowser.org/oma/group/F1N1Q7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q69ZK0-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "gene_name": "Prex1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAPGSGGGDGGGDPGGDGAHPDARGPVSGPCAAARDSERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLQRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHTAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTELLLQGNLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIPPQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETILNQFFCSRRPLRLLVATKAKETIKVPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGLCAGQCILKVNGTSVANDGALEVLEHFQAFRNHREEALGLYQWVYHSHEDAQLARASQGAPDEDPQEDDQPDSALPLLSLGPQLSLHEDSAVVSLTLDNVHLEHGVVYEYMSTAGAKCHVLEKIVEPRGCFRLAAKILEAFAVDDSIFVQNCGRLMAMSSAIVTMSHYEFHNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQASLEPHPLCGLDFCPTNCHVNLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGLNPMAYTQHCITTMAAPSWKCSPAVDEDSQGQGLNDSSYGSASGAPSQQDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSAAPAPCDPSLVEETSSSPPVSEESEVDRTDHSGIKKVCFKVSEDEQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSIHALLKGPVMSRAFEETRHFPMKHSWQEFKQKEECTVRGRNLIQISIQEDPWNLPSSIRTLVDNIQQYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVAAVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPASVKEERTMLEDIWVTLSELDNVTFSFKQLDENSVANTNVFYHIEGSRQALKVVFYLDGFHFSRLPSRLEGGASLRLHTVLFTKALESVEGPPPPGNQAAEELQQEINAQSLEKVQQYYRKLRAFYLERSNLPTDAGATAVKIDQLIRPINALDELYRLMKTFVHPKAGAAGSLGAGLIPVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQGPRVEILAKNLRIKDPMPQGAPRLYQLCQPPVDGDL", "length": 1650 }, "evidence": [ { "id": "F1N1Q7", "url": "https://omabrowser.org/oma/group/F1N1Q7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TCU6-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "gene_name": "PREX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSKQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL", "length": 1659 }, "evidence": [ { "id": "F1N1Q7", "url": "https://omabrowser.org/oma/group/F1N1Q7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "leukocyte activation", "id": "GO:0045321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045321", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "F1N1Q7", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1041, "end_pos": 1043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1184, "end_pos": 1186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1402, "end_pos": 1404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 756, "end_pos": 758, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 419, "end_pos": 494, "start_aa": "Met", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 238, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 623, "end_pos": 670, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q7" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 269, "end_pos": 390, "start_aa": "Gln", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1041, "end_pos": 1043 }, { "start_pos": 1184, "end_pos": 1186 }, { "start_pos": 1402, "end_pos": 1404 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 756, "end_pos": 758 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4B0-1", "uniprot_ac": "F1N4B0", "uniprot_id": "F1N4B0_BOVIN", "mass": { "chemical_mass": 135451.0, "monoisotopic_mass": 135451.0 }, "refseq": { "ac": "XP_002690361", "name": "SAM and SH3 domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690361" }, "gene_names": [ { "name": "SASH1", "type": "recommended", "evidence": [ { "id": "F1N4B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" } ] }, { "name": "SASH1", "type": "synonym", "evidence": [ { "id": "XP_002690361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690361" } ] } ], "protein_names": [ { "name": "SAM and SH3 domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "F1N4B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B0/entry#names_and_taxonomy" } ] }, { "name": "SAM and SH3 domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002690361", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690361" } ] } ], "function": [ { "annotation": "Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LPN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPN3#function" }, { "database": "UniProtKB", "id": "ARBA00057807", "url": "https://www.uniprot.org/uniprotkb/ARBA00057807#function" }, { "database": "UniProtKB", "id": "A0AAA9S7F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7F2#function" }, { "database": "UniProtKB", "id": "A0AAA9TAK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK8#function" }, { "database": "UniProtKB", "id": "A0AAA9SSF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF9#function" }, { "database": "UniProtKB", "id": "A0AAA9SST9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST9#function" }, { "database": "UniProtKB", "id": "F1N4B0", "url": "https://www.uniprot.org/uniprotkb/F1N4B0#function" }, { "database": "UniProtKB", "id": "A0AAA9TKL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4B0", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SASH1", "url": "https://www.uniprot.org/uniprotkb/F1N4B0", "locus": { "chromosome": "9", "start_pos": 85857293, "end_pos": 84831208, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001826", "url": "https://www.ensembl.org/id/ENSBTAG00000001826" } ] } } ], "crossref": [ { "id": "F1N4B0", "url": "https://alphafold.ebi.ac.uk/entry/F1N4B0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001826", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001826", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09492", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09492", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09559", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09559", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11967", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11967", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539603", "url": "https://www.ncbi.nlm.nih.gov/gene/539603", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539603", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SMSDWLI", "url": "https://omabrowser.org/oma/group/SMSDWLI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPN3", "url": "https://www.orthodb.org/?gene=A0A3Q1LPN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4B0", "url": "https://www.orthodb.org/?gene=F1N4B0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12301", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12301", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12301:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12301:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26285", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26285", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690361", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690361", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SST9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SST9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4B0", "url": "https://www.uniprot.org/uniprotkb/F1N4B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4B0-1", "url": "https://www.uniprot.org/uniprotkb/F1N4B0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQDAGAAGAAPEPEPEPASEPEVGAGMSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1236, "header": "tr|F1N4B0-1|F1N4B0_BOVIN Isoform 1 of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=2 CANONICAL=F1N4B0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPN3/entry", "sequence": { "sequence": "MAKDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1196, "header": "tr|A0A3Q1LPN3-1|F1N4B0_BOVIN Computationally mapped isoform of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=2 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85671476, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077167.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077167.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058901.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058901.2" } ] } }, { "isoform_ac": "A0AAA9S7F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7F2/entry", "sequence": { "sequence": "MEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1151, "header": "tr|A0AAA9S7F2-1|F1N4B0_BOVIN Computationally mapped isoform of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=1 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85751058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089944.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089944.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079847.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079847.1" } ] } }, { "isoform_ac": "A0AAA9SSF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF9/entry", "sequence": { "sequence": "MLPLHPSRCLLPTCLAVEPMESKGKPQDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1220, "header": "tr|A0AAA9SSF9-1|F1N4B0_BOVIN Computationally mapped isoform of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=1 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85227277, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133456.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133456.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088268.1" } ] } }, { "isoform_ac": "A0AAA9SST9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST9/entry", "sequence": { "sequence": "MEDQDGRDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1200, "header": "tr|A0AAA9SST9-1|F1N4B0_BOVIN Computationally mapped isoform of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=1 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85600178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090790.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090790.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087188.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087188.1" } ] } }, { "isoform_ac": "A0AAA9TAK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK8/entry", "sequence": { "sequence": "MDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1194, "header": "tr|A0AAA9TAK8-1|F1N4B0_BOVIN Computationally mapped isoform of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=1 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85663284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092768.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092768.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095742.1" } ] } }, { "isoform_ac": "A0AAA9TKL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL0/entry", "sequence": { "sequence": "MEHFAREAEFWSRLMDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1208, "header": "tr|A0AAA9TKL0-1|F1N4B0_BOVIN Computationally mapped isoform of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=1 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85511437, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102707.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102707.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097725.1" } ] } }, { "isoform_ac": "F1N4B0-1", "url": "https://www.uniprot.org/uniprotkb/F1N4B0/entry", "sequence": { "sequence": "MEQDAGAAGAAPEPEPEPASEPEVGAGMSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPEASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSTALDPADWPDGSYPTFEGSSNCNSREQSEDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEQVFENSPVPDERSALYSGVHKKPFFFDASPEKPPEDDSDSLTTAPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEDDKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHIGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPSSQPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRATRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKTGLSAKSSTESSLKSFNRNQLGNYPTLPLTKSVDALKQGGEGRLGGGLTPLASKSCDPPCVTDLNKNRRSLPVSICRSCETLEGPQTVETWPRSHSLDNLQGEPEKDVPGEVTEPSPEIVPEVPQKTAPSVTKVPSPKRDSAVDNALLLTQSKRFSEPQKTTAKKLDGPMGPFSRGASPPPCLPKTFDTQPPAIKPSLTRTPLEGHRKGLDFEGTHHPPGTKEGMDAEQRGPEVRTQAKPPVQPPPVPAKKSRERLANGLHPVPPGPPGVPSPDAPGLPLKKGSPGGPSDCPLVVAVARPPPGPEPGSPPSTRPPPWLSELPESASLQEHGVRLGPALARKVSCARGLDLEMLTENKLRAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGYVSSVSDWLVSIGLPMYASALSEAGFSTLGQVPSLSHTCLQEAGITEERHISKLVSAARLFKLPPGPEAM", "length": 1236, "header": "tr|F1N4B0-1|F1N4B0_BOVIN Isoform 1 of SAM and SH3 domain-containing protein 1 OS=Bos taurus OX=9913 GN=SASH1 PE=4 SV=2 CANONICAL=F1N4B0-1" }, "locus": { "chromosome": "9", "start_pos": 85856289, "end_pos": 85670339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002389.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002389.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002389.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002389.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539603", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539603", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GLI1-1", "protein_name": "SAM and SH3 domain-containing protein 1", "gene_name": "Sash1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEDAGAASPAPEPEVDPAREPEPEPESEPEAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKYPLHKSNSEDGCVGKADWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSSALDPADWPDGSYPTLDGSSTCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFESPPVQDERSALYSGVHKKPFFYDGSPEKPPEDSADSLTPSPSSSSLETWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGVSTDGVFFYDSHRRRHHFLVSLEEVQSIRKQIRLKKTDTNYSCSRTFLCQRPSRKGVNGTTCDLLPRPKPKGGGGCGFPGRRGRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASDRTLSKAEKQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPSASRISLGKKVKSVKETMRKRMSKKYSSPVTEQDSGLDGTPGSPTSVKPDSEHMDKPKLKAGGSVESLRSSLSGQSSMSGHTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRPTRRRRKGRPSQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLADSQGLSGRSPRDSGCYESSENLENGKTQKPSALSTKSSTESNLKSFNRSQPGNYPTLPLTKSGEVRKQGEESRLGRGLAPDTAKCCDVPCVTGLSKNRRSLPVSICRSCETLEGPEPVESWPRSHSLDDLQGDADVGKDVPTEKPETCPENVPEVPQKASACTSKALPRGRDPTAEDVMFLTQSKRFSDPPKTMAKKLEGSAVASNLGIAPPQCIPRNFEAQPPVKPGLTRTSLEGLRKGHDHHSLGTKEGVDGEQSTPETRTQSRHPSQPPPVPAKKSRERLANGLHLVPSPEAPILPLKKASPASPVSPSDCPSPREPRSSSGTEPGSPVCTRPPPWLAELPESTSLQEHGVKLGPVLSRKVSCIRGVDLEMLTENKLQAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGCVTSVSDWLISIGLPMYTSTLSDAGFSALSQVPSLSHTCLQEAGITEERHIRKLVTAARLFKLPPSPEAM", "length": 1397 }, "evidence": [ { "id": "F1N4B0", "url": "https://omabrowser.org/oma/group/F1N4B0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O94885-1", "protein_name": "SAM and SH3 domain-containing protein 1", "gene_name": "SASH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM", "length": 1247 }, "evidence": [ { "id": "F1N4B0", "url": "https://omabrowser.org/oma/group/F1N4B0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P59808-1", "protein_name": "SAM and SH3 domain-containing protein 1", "gene_name": "Sash1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEDAGAASPAPEPEPEVDPARELEPEAGVSESISRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKYPLHKSNSEDGCVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSSTLDPADWPDGSYPTLDGSSTCNSREQSDDETEDSVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSAEGGEEHVFENSPVQDERSALYSGVHKKPFFYDGSPEKPPEDDADSLTPSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPAGKEGDFVYKEVIKSPPAPRISLGKKVRSVKETMRKRMSKKYSSPVSEQDSGLDGMPSSPASGKPDSEHVDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRPTRRRKKGRPSQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDNQGLSGRSPRDSGCYESSENLENAKTHKPSVLSTKSSTESNLKSFTRSQPGNYPTLPLMKSGEVRKQGEEGRLGRGLAPDTAKSCDVPSVTDLSKNRRSLPVSICRSCETLEGPEPVESWPRSHSLDDLQGDADVGKNVPTEMPETCSQNVPEVPQKTSACTSKALPRGRDPTADVMLLTQSKRFSDPPKTMAKKLDGSVVASNLGIAPPQCIPRDFEAQPPVKPGLTRTSLEGLRKGHDHHPLGTKEGVDGEQSAPETRTQSRHPSQPPPVPAKKSRERLANGLHLVPSPEAPILPLKKASPASPVSPSDCPSPREPRPSSGTEPGSPACTRPPPWLAELPESTSLQEHGVKLGPVLSRKVSCVRGVDLEMLTENKLQAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLEQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGCVASMSDWLISIGLPMYTSTLSDAGFSTLSQVPSLSHSCLQEAGITEERHIRKLITAARLFKLPPSPEAM", "length": 1230 }, "evidence": [ { "id": "F1N4B0", "url": "https://omabrowser.org/oma/group/F1N4B0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4B0", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "F1N4B0", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mitogen-activated protein kinase kinase kinase binding", "id": "GO:0031435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031435", "evidence": [ { "database": "UniProtKB", "id": "F1N4B0", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4B0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1236, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4B0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4B0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 624, "end_pos": 688, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B0" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 545, "end_pos": 606, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1I2-1", "uniprot_ac": "F1N1I2", "uniprot_id": "F1N1I2_BOVIN", "mass": { "chemical_mass": 31921.0, "monoisotopic_mass": 31921.0 }, "refseq": {}, "gene_names": [ { "name": "SCGN", "type": "recommended", "evidence": [ { "id": "F1N1I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ] } ], "protein_names": [ { "name": "Secretagogin", "type": "recommended", "evidence": [ { "id": "F1N1I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1I2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCGN", "url": "https://www.uniprot.org/uniprotkb/F1N1I2", "locus": { "chromosome": "23", "start_pos": 32189851, "end_pos": 32242064, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019926", "url": "https://www.ensembl.org/id/ENSBTAG00000019926" } ] } } ], "crossref": [ { "id": "F1N1I2", "url": "https://alphafold.ebi.ac.uk/entry/F1N1I2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019926", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019926", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16178", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16178", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618206", "url": "https://www.ncbi.nlm.nih.gov/gene/618206", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QFMSAYD", "url": "https://omabrowser.org/oma/group/QFMSAYD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQJ3", "url": "https://www.orthodb.org/?gene=A0A3Q1LQJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1I2", "url": "https://www.orthodb.org/?gene=F1N1I2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19972:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19972:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13202", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13202", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LQJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1I2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1I2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSAREPTQGSLDAAGFWQVWQRFDVEEKGYIEEKELDAFFYHMLTKLGVDDAVKEENVQKMKQQFMAPHNVSKDGCIQMKELAGMFLSEDENFLLLFRQETPLDSSVEFMRIWRKYDADSSGFISAAELCNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDACSSEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVQPSIRGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP", "length": 276, "header": "tr|F1N1I2-1|F1N1I2_BOVIN Isoform 1 of Secretagogin OS=Bos taurus OX=9913 GN=SCGN PE=4 SV=1 CANONICAL=F1N1I2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQJ3/entry", "sequence": { "sequence": "MDSAREPTQGSLDAAGFWQVWQRFDVEEKGYIEEKELDAFFYHMLTKLGVDDAVKEENVQKMKQQFMAPHNVSKDGCIQMKELAGMFLSEDENFLLLFRQETPLDSSVEFMRIWRKYDADSSGFISAAELCNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDKNKDVAWKWCQRFRNTFLGACSSEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVQPSIRGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP", "length": 266, "header": "tr|A0A3Q1LQJ3-1|F1N1I2_BOVIN Computationally mapped isoform of Secretagogin OS=Bos taurus OX=9913 GN=SCGN PE=4 SV=1 CANONICAL=F1N1I2-1" }, "locus": { "chromosome": "23", "start_pos": 32241965, "end_pos": 32190284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068736.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068736.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062451.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062451.1" } ] } }, { "isoform_ac": "A0AAA9TXV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXV6/entry", "sequence": { "sequence": "MDSAREPTQGSLDAAGFWQVWQRFDVEEKGYIEEKELDAFFYHMLTKLGVDDAVKEENVQKMKQQFMAPHNVSKDGCIQMKELAGMFLSEDENFLLLFRQETPLDSSVEFMRIWRKYDADSSGFISAAELCNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDACSSEERKRDFEKIFAHYDVPSIRGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP", "length": 253, "header": "tr|A0AAA9TXV6-1|F1N1I2_BOVIN Computationally mapped isoform of Secretagogin OS=Bos taurus OX=9913 GN=SCGN PE=4 SV=1 CANONICAL=F1N1I2-1" }, "locus": { "chromosome": "23", "start_pos": 32241965, "end_pos": 32190284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106292.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106292.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103168.1" } ] } }, { "isoform_ac": "F1N1I2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1I2/entry", "sequence": { "sequence": "MDSAREPTQGSLDAAGFWQVWQRFDVEEKGYIEEKELDAFFYHMLTKLGVDDAVKEENVQKMKQQFMAPHNVSKDGCIQMKELAGMFLSEDENFLLLFRQETPLDSSVEFMRIWRKYDADSSGFISAAELCNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDACSSEERKRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVQPSIRGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP", "length": 276, "header": "tr|F1N1I2-1|F1N1I2_BOVIN Isoform 1 of Secretagogin OS=Bos taurus OX=9913 GN=SCGN PE=4 SV=1 CANONICAL=F1N1I2-1" }, "locus": { "chromosome": "23", "start_pos": 32241965, "end_pos": 32190284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026544.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026544.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026544.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026544.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E1BY74-1", "protein_name": "Secretagogin", "gene_name": "SCGN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESGAERRLDAAAFLGAWRRFDADDNGYIEGKELDNFFRHLLEKLRPDDTITEEEVQRMKEQFMSAYDVTTDGRLQIQELANVILPDDENFLLLFRRETPLDNSVEFMRIWRSYDADGSGFISAGELKDFLRDLFLQHNRVVTEVKLEEYTDTMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDACSTEERRRDFEKIFAHYDVSKTGALEGPEVDGFVKDMMELVKPSISGVDLDKFRQILLNHCDVNRDGKIQKSELALCLGLKLNP", "length": 273 }, "evidence": [ { "id": "F1N1I2", "url": "https://omabrowser.org/oma/group/F1N1I2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5XJX1-1", "protein_name": "Secretagogin", "gene_name": "scgn", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDSAFANLDAAGFLQIWQHFDADDNGYIEGKELDDFFRHMLKKLQPKDKITDERVQQIKKSFMSAYDATFDGRLQIEELANMILPQEENFLLIFRREAPLDNSVEFMKIWRKYDADSSGYISAAELKNFLKDLFLQHKKKIPPNKLDEYTDAMMKIFDKNKDGRLDLNDLARILALQENFLLQFKMDASSQVERKRDFEKIFAHYDVSRTGALEGPEVDGFVKDMMELVRPSISGGDLDKFRECLLTHCDMNKDGKIQKSELALCLGLKHKP", "length": 272 }, "evidence": [ { "id": "F1N1I2", "url": "https://omabrowser.org/oma/group/F1N1I2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "transport vesicle membrane", "id": "GO:0030658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030658", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" }, { "name": "terminal bouton", "id": "GO:0043195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043195", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N1I2", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1I2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 276, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1I2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1I2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1I2" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 47, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5U2-1", "uniprot_ac": "F1N5U2", "uniprot_id": "F1N5U2_BOVIN", "mass": { "chemical_mass": 136742.0, "monoisotopic_mass": 136742.0 }, "refseq": { "ac": "XP_005221883", "name": "zinc finger protein 592 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221883" }, "gene_names": [ { "name": "ZNF592", "type": "recommended", "evidence": [ { "id": "F1N5U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U2" } ] }, { "name": "ZNF592", "type": "synonym", "evidence": [ { "id": "XP_005221883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221883" } ] } ], "protein_names": [ { "name": "Zinc finger protein 592", "type": "synonym", "evidence": [ { "id": "F1N5U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 592 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005221883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221883" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQM6#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1MN68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN68#function" }, { "database": "UniProtKB", "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF592", "url": "https://www.uniprot.org/uniprotkb/F1N5U2", "locus": { "chromosome": "21", "start_pos": 22454629, "end_pos": 22424790, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001616", "url": "https://www.ensembl.org/id/ENSBTAG00000001616" } ] } } ], "crossref": [ { "id": "F1N5U2", "url": "https://alphafold.ebi.ac.uk/entry/F1N5U2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001616", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001616", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516451", "url": "https://www.ncbi.nlm.nih.gov/gene/516451", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041697", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SVKKYPC", "url": "https://omabrowser.org/oma/group/SVKKYPC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQM6", "url": "https://www.orthodb.org/?gene=A0A3Q1LQM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MN68", "url": "https://www.orthodb.org/?gene=A0A3Q1MN68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N5U2", "url": "https://www.orthodb.org/?gene=F1N5U2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47222:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47222:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9940951", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005221883", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5U2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5U2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGLCVDENVSLSHSGSASDVPAVSVIVKNTSRQESFEAEKDHIAPSLLHNGFRGSDLPADPHSLGHNCGKFDSTFMNGDSTRGFPGKLEASKSEPLPTFNQFSPISSPEPEDAIKDNGFGMKPKHSDSYFPPPPGCGSVGGPVLEALTKFPVPELHMFDHFCKKEPKPEPLPLGSPQEHERGGQKALEVHKELDASRFFGDALDFSSHPGNSIGEPKGLASELGTGSAFPPRQRLKPAHSKLSSCVAALVALQAKRVANVAKEDQTSHTKDPSGPAKEGSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPSGSPLGSATAEAPSEAPEDEATTLSGVEHFAEVGAQPGSPQSDRKGEECTAKASEPSPSCFSSGARGQKGAASGTLEGRKPQQSPAPPASAPAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQPTQMSVPLVHQVKKAAPLVLEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSQTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSTPANSTAPAAAAPPSPSQPGQASSNASTPLPALPLYPDPVRLIRHSIKCLECHKQMRDYMAMAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGALCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNASTAQVGVFKCPECPLLFLQKPELMQHVKSTHGVPRNVDELSSLQSSADSSSSRPGPRVPAEPPALSVTARGSALPSSRWGRPEAHRRAEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKVYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKARPSGGHSPQVNHLKRPVSGVGAAPDTSNGTPVSSTKRHKSLFQCAKCSFATDSGLEFQRHIPQHQKDSSTAQCLLCGLCYTSAGSLSRHLFIVHKVRDQEEEEAEAAEPEEGSGEEVPMETRENGLEESAEEPLVGDSETGRSLGLAQDEDGAQDAPSRPQTSQDRDSHTPSPQV", "length": 1265, "header": "tr|F1N5U2-1|F1N5U2_BOVIN Isoform 1 of Zinc finger protein 592 OS=Bos taurus OX=9913 GN=ZNF592 PE=3 SV=1 CANONICAL=F1N5U2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQM6/entry", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGLCVDENVSLSHSGSASDVPAVSVIVKNTSRQESFEAEKDHIAPSLLHNGFRGSDLPADPHSLGHNCGKFDSTFMNGDSTRGFPGKLEASKSEPLPTFNQFSPISSPEPEDAIKDNGFGMKPKHSDSYFPPPPGCGSVGGPVLEALTKFPVPELHMFDHFCKKEPKPEPLPLGSPQEHERGGQKALEVHKELDASRFFGDALDFSSHPGNSIGEPKGLASELGTGSAFPPRQRLKPAHSKLSSCVAALVALQAKRVANVAKEDQTSHTKDPSGPAKEGSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPSGSPLGSATAEAPSEAPEDEATTLSGVEHFAEVGAQPGSPQSDRKGEECTAKASEPSPSCFSSGARGQKGAASGTLEGRKPQQSPAPPASAPAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQPTQMSVPLVHQVKKAAPLVLEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSQTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSTPANSTAPAAAAPPSPSQPGQASSNASTPLPALPLYPDPVRLIRHSIKCLECHKQMRDYMAMAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGALCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNASTAQVGVFKCPECPLLFLQKPELMQHVKSTHGVPRNVDELSSLQSSADSSSSRPGPRVPAEPPALSVTARGSALPSSRWGRPEAHRRAEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKVYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKARPSGGHSPQVNHLKRPVSGVGAAPDTSNGTPVSSTKRHKSLFQCAKCSFATDSGLEFQRHIPQHQKDSSTAQCLLCGLCYTSAGSLSRHLFIVHKA", "length": 1186, "header": "tr|A0A3Q1LQM6-1|F1N5U2_BOVIN Computationally mapped isoform of Zinc finger protein 592 OS=Bos taurus OX=9913 GN=ZNF592 PE=3 SV=1 CANONICAL=F1N5U2-1" }, "locus": { "chromosome": "21", "start_pos": 22454451, "end_pos": 22424809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082824.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082824.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057286.1" } ] } }, { "isoform_ac": "A0A3Q1MN68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN68/entry", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGLCVDENVSLSHSGSASDVPAVSVIVKNTSRQESFEAEKDHIAPSLLHNGFRGSDLPADPHSLGHNCGKFDSTFMNGDSTRGFPGKLEASKSEPLPTFNQFSPISSPEPEDAIKDNGFGMKPKHSDSYFPPPPGCGSVGGPVLEALTKFPVPELHMFDHFCKKEPKPEPLPLGSPQEHERGGQKALEVHKELDASRFFGDALDFSSHPGNSIGEPKGLASELGTGSAFPPRQRLKPAHSKLSSCVAALVALQAKRVANVAKEDQTSHTKDPSGPAKEGSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPSGSPLGSATAEAPSEAPEDEATTLSGVEHFAEVGAQPGSPQSDRKGEECTAKASEPSPSCFSSGARGQKGAASGTLEGRKPQQSPAPPASAPAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQPTQMSVPLVHQVKKAAPLVLEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSQTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSTPANSTAPAAAAPPSPSQPGQASSNASTPLPALPLYPDPVRLIRHSIKCLECHKQMRDYMAMAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGALCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNASTAQVGVFKCPECPLLFLQKPELMQHVKSTHGVPRNVDELSSLQSSADSSSSRPGPRVPAEPPALSVTARGSALPSSRWGRPEAHRRAEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKVYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKARPSGGHSPQVNHLKRPVSGVGAAPDTSNGTPVSSTKRHKSLFQCAKCSFATDSGLEFQRHIPQHQKDSSTAQCLLCGLCYTSAGSLSRHLFIVHKELNLHLLCLLHWLVSSLPFEPPGKSLRSPRRFYLLDPA", "length": 1223, "header": "tr|A0A3Q1MN68-1|F1N5U2_BOVIN Computationally mapped isoform of Zinc finger protein 592 OS=Bos taurus OX=9913 GN=ZNF592 PE=3 SV=2 CANONICAL=F1N5U2-1" }, "locus": { "chromosome": "21", "start_pos": 22454451, "end_pos": 22424809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073365.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073365.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072674.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072674.2" } ] } }, { "isoform_ac": "F1N5U2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5U2/entry", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGLCVDENVSLSHSGSASDVPAVSVIVKNTSRQESFEAEKDHIAPSLLHNGFRGSDLPADPHSLGHNCGKFDSTFMNGDSTRGFPGKLEASKSEPLPTFNQFSPISSPEPEDAIKDNGFGMKPKHSDSYFPPPPGCGSVGGPVLEALTKFPVPELHMFDHFCKKEPKPEPLPLGSPQEHERGGQKALEVHKELDASRFFGDALDFSSHPGNSIGEPKGLASELGTGSAFPPRQRLKPAHSKLSSCVAALVALQAKRVANVAKEDQTSHTKDPSGPAKEGSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPSGSPLGSATAEAPSEAPEDEATTLSGVEHFAEVGAQPGSPQSDRKGEECTAKASEPSPSCFSSGARGQKGAASGTLEGRKPQQSPAPPASAPAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQPTQMSVPLVHQVKKAAPLVLEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSQTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSTPANSTAPAAAAPPSPSQPGQASSNASTPLPALPLYPDPVRLIRHSIKCLECHKQMRDYMAMAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGALCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNASTAQVGVFKCPECPLLFLQKPELMQHVKSTHGVPRNVDELSSLQSSADSSSSRPGPRVPAEPPALSVTARGSALPSSRWGRPEAHRRAEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKVYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKARPSGGHSPQVNHLKRPVSGVGAAPDTSNGTPVSSTKRHKSLFQCAKCSFATDSGLEFQRHIPQHQKDSSTAQCLLCGLCYTSAGSLSRHLFIVHKVRDQEEEEAEAAEPEEGSGEEVPMETRENGLEESAEEPLVGDSETGRSLGLAQDEDGAQDAPSRPQTSQDRDSHTPSPQV", "length": 1265, "header": "tr|F1N5U2-1|F1N5U2_BOVIN Isoform 1 of Zinc finger protein 592 OS=Bos taurus OX=9913 GN=ZNF592 PE=3 SV=1 CANONICAL=F1N5U2-1" }, "locus": { "chromosome": "21", "start_pos": 22445952, "end_pos": 22424809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002120.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002120.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002120.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002120.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 542, "start_aa": "Thr", "end_pos": 542, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr542", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9940951", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "resource": "Reactome", "description": "Interaction of NuRD complexes with transcription factors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B5T2-1", "protein_name": "Zinc finger protein 592 isoform X1", "gene_name": "znf592", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDATSLDAKEAIHGNQDEGDGHLKHSEMCMDTTVSIPHPVPTADAPAVSVIVKNTSRQNSYENLVEKESPHLGHLLQNGFKSSVGSLETHPSSYPRLDSSSVNGENFNHSLEKTPVLYKPEKGPTLSESVSQFSPISSPESEDIQSNGIDDCPKSAETSYFPSDSLFTSPTVTVLDYLEKADVPDSGCNYSHCGSKGVDDLESDSSSFKDDLVGKNADSATKSDCSQDCRTNTYPTLETNSPSRPCAKAHTSRLSSCIDALAALNPKKDSGGHINSKDIPVTPKETVKISQKIPISPRSPKSPLEVVKRFTKQPDSPMSICSDSSGKASPAVATGSPPAIPRVRIKTIKTSSGEIKRTVTSILPDSETEDLMSPFGSSPSQSSVEEAFSKTLPPNHSTDIISEVIFEDGSQEASKMASSGSTKSVRSSKSPQIQNIGHALKTTEGGTQQRKATSAQIGSSANTNYLPKALHLANLNLVPHSVAASVTARSSTNRQEPSQLSSSMVCSSVPLVHQVKKVSPNTRAVVPNTAAGTLNRLLNYSNPVPTYVPNLSPPPGTNIKLPTQGYCCLECGDSFGLEKSLAYHYSRRSVHIEVACTHCSKTLVFFNRCALLAHARDHKNKGMVMQCTQLFMKPIAVDQMLVPTKTSLQSAIQIPCGNTTTEPSKGQVVLPLYPDNVIRNGSKCLECNKQISDYTALARHYQKSSEDEGLICKVCSMLLPNKCSYRAHQRIHTHKSPYCCPECGALSRSVDIQKHVKENCLHYTRKIGYSCLHCEMLFMSLSHLKSHIEEKHCEVFYKCTTCPVAFKSYDGCLMHVKNKHGGSEPNHQVIYKCSCETVFKRRQLLYQHFHNRICVFKCPECTSLFPEKLPLVQHFKTIHGGVFRGEAEKSSKTTETSLPKNLQPSLTKAGNEACVKEMENSTARKSSAEAGIKNTGWTCGVCLLWVPDRETYVSHMKTSHGKSLKRQPCRLCERSFNSPMSLKRHIRNDHNGKKKVYTCWYCTSERMSFTEHSLLKNHISLMHGVKNPDFSQMAKLESQEVGKIRSERPKKRRAEHPDGVKGNGETSHNTPSKRHKPLYRCAKCGFTSEAQAQFQEHIPQHKSDSNTPQCQHCGLCFTSQLALSRHLFIVHKVKEPEEHEDFKDGKEREISTDLSDKTVPLLRNKTGLSTAEDQLGLHNVPTDTDYNTQTSENSGLEDKKA", "length": 1219 }, "evidence": [ { "id": "F1N5U2", "url": "https://omabrowser.org/oma/group/F1N5U2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZMT9-1", "protein_name": "Zinc finger protein 592", "gene_name": "ZNF592", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKETIPSAGEENENHLKSSGICIDENVSLSHSLPPSDAPVVSVIVKNTSRQESFEAEKEGNHLGTGLLHNGFRGSDLPSEAHALVHNYGKFESTFINGDSSRSYSEKLDQSKSEPLPTFSQFSPISSPEPEDTFKENSIGDKPKHAQTPYFPPPSMYMPTGASVLDHFRKVPEPELSMFDQYCKKEQKMEIHFQPESRQEMSRREQDKATERFVESGKDLVDTNSFLGEGLVFGELPHSNLGEDKGSVPELNLSSSVPPRQRLKPTHSKLSSCVAALVALQAKKVACIPKGDQPNLIKEPGPFKDGTKGSPKMPKSPKSPRSPLEVVRKASKQPESPRSVCSDSSGKGSPSMAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPESDELGKSLEESPLETSSAEEFIKSFPSPDTSAVMESEASKNSTKNGAAIAIQLSNIVSPYTDGLKADLAANTTSLVSLSPLPNCGGGAIKVGVVGQQLNKKQHQQQGIVVQPSNVTASSSLLPKAVHLANLNLVPHSVAASVTAKSSAQRRNQPQVTQMSVPLVHQVKKAAPVIVEAFNKVLHSANPVPIYSPNLSPPPDTSINLPASGYCCLECGDSFALEKSLTQHYSRRSVHIEVMCTQCSTMLLFFNKCSLLKHARDHKSKGFIMQCSQLVMKPISLDQMFSPSASSSASSTPQTLHLSSPSRKPNASSGNGVGISTNTQPAMPLYPDPLRLIRHGLKCLECNKQAQDYVALAAHYQRTSEDSERLTCQVCQMMLPNQCSYCAHQRIHAHKSPYCCPECGAVCRSAYFQTHVKENCLHYSRKVGFRCIHCGVVFMTLALLKVHIHEKHCEVFHKCSFCPMAFKSADSTVAHMTSQHSAEPHKTTQVIYKCSCETVFNKKKLLQEHFEQNTNKLLVGVFKCPQCQLVYMQKQQLMQHVKGVHGVPQNPEELLNFRQKSEKIAKNQVHNTPKELLVANGTSHSPLPRKDMRVEGHNLESKSRLRRTGWTCKECSQWMPDRETYVSHMKRSHGRAMKRYPCRQCERSFNASNSLRRHIRNNHDTAKKVYTCWYCTDENQTFPQPFMLENHISLMHGIKNPDLSQMAKARAPDRDTAEARSPKRMATNELGQAETAAGSDAPPAKKLKAHWKCAKCGFATDISTEFQEHIPQHKTDSSTYQCLFCGLCYTSQISLNRHLFIVHKVKDEEEEEEEEDEEEQEEGEEVREKLRAETNENGHEGYNGEMNTTAEEESLECKECKTDSALCEHRQTCGVEGPRSTSQNNHSKSVKT", "length": 1302 }, "evidence": [ { "id": "F1N5U2", "url": "https://omabrowser.org/oma/group/F1N5U2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZJG8-1", "protein_name": "Zinc finger protein 592", "gene_name": "Zfp592", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKSSGMCMDENVSLSHSGSVPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDSHHCGKFDSTFINGDSARSFTSKLEPSKSEPLPTFNQFSPISSPEPEDPVKDNGFGIKSKHSDSYFPPPPGTVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLESQQEHEQGGQKVVEPHKDLDSSRFFGEALEFNSHPSNSIGEPKKLVPELSACSSVPPRQRLKPAHSKLSSCVAALVALQAKRVANVTKEDQPGHIKDSSGPTKEGSKGSPKMPKSPKSPRSPLEATRKNIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRVLPDPDDPSESPAGGTSAEVPSEVPGDEGSAMPVEEHFSEAGIDSGSPQGDRKGGENMINKTSDSLSPCRTSGPRVPKGSALNSQASKKQQSTALQASTPAPASLLPKAVHLANLNLVPHSVAASVTAKSSAQRRSQPQVTQMTVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYSRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVAAPVNSTAPATPAASSSPKPSPTLDNASPVIPALPLYPDPVRLIRYGTKCPECHKQMRDYMVLATHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHYARKVGYRCIHCGVIHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTMDHSTTQHPTQPHKPSQLIYKCSCEMIFNKKRHIQQHFYQNVSKTQAAVFKCPECPLLFLQKPELMQHVKNTHGVPRNVEELSSLQSSTDTSSNRPGSRAPTEPPATNVATRGSSLTAGRWGRPDAHRRAEARPRMRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLRRYPCRQCEQSFHNPSSLRKHIRNNHDTVKKVYTCGYCSEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKVKHAGGHSPQVNHLKRPVSRMADAPGTSNGATASSTKRHKPLFQCARCTFSTDSELEFQSHIPQHQVDSSTAQCPLCGLCYTSARSLSRHLFIVHKVRGQEEGGEEIVQVKVEATDPEACSGEEVAVKTGENGLEECVSEPLVADIEPRRSLGLAVDEDSAQDPQNQPQASQDQNSHALSPQV", "length": 1262 }, "evidence": [ { "id": "F1N5U2", "url": "https://omabrowser.org/oma/group/F1N5U2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHZ4-1", "protein_name": "Zinc finger protein 592", "gene_name": "Znf592", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQAPSEENESPLKSSGMCIDENVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHIAPSLLHNGFRGSDLPPDSHHCGKFDSTFINGDSARSFTSKLEPSKSEPLPTFNQFSPISSPEPEDPVKDNGFGIKSKHSDSYFPPPPGTVGGPVLEALSKFPVPELHMFDHFCKKEPKPEPLPLESQQEHEQGGQKVVEPHKDLDSSRFFGEALEFNSHPSNSIGEPKKLAPELSACSSVPPRQRLKPAHSKLSSCVAALVALQAKRVANVTKEDQPGHTKDSSGPTKEGSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPAESPAGSTITEAPSEAPGDEGTAMPVEEHFSEAGIHSGSPQGDRKGDENMIKTSDSSSPCRISGSRVPKGSALNSQASKKQQSTAPQASTPAASLLPKAVHLANLNLVPHSVAASVTAKSSAQRRSQPQVTQMTVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYSRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVAAPVNSTAPATPAASSSPKPSPTLDNASSVIPALPLYPDPVRLIRYGTKCPECHKQMRDYMVLATHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHYARKVGYRCIHCGVIHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTMDHSTTQHPTQPHKPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQAGVFKCPECPLLFLQKPELMQHVKNTHGVPRNVEELSSLQSSTDTSSNRPGSRAPAEPPATNVAARGSSLTAGRWGRPEAHRRAEARPRMRSTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHNPSSLRKHIRNNHDTVKKVYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKVRHPGGPSPQVNHLKRPVSRMADAPGTSNGATVSSTKRHKSLFQCAKCTFATDSELEFQSHIPQHQVDSSTAQCLLCGLCYTSTSSLNRHLFIVHKVRDQEEGGEDIVEVKVEAPDSEACSGEEVAMETKENGLEECASEPLVTDLGGQQGLALDEDSAQDPQNQPQASQDQNSHALSPQV", "length": 1262 }, "evidence": [ { "id": "F1N5U2", "url": "https://omabrowser.org/oma/group/F1N5U2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92610-1", "protein_name": "Zinc finger protein 592", "gene_name": "ZNF592", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPSGRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV", "length": 1267 }, "evidence": [ { "id": "F1N5U2", "url": "https://omabrowser.org/oma/group/F1N5U2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N5U2", "url": "https://www.uniprot.org/uniprotkb/F1N5U2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1118, "end_pos": 1120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 579, "end_pos": 581, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 891, "end_pos": 893, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5U2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1265, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5U2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5U2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 542 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1118, "end_pos": 1120 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 579, "end_pos": 581 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 697, "end_pos": 699 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 891, "end_pos": 893 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4A4-1", "uniprot_ac": "F1N4A4", "uniprot_id": "F1N4A4_BOVIN", "mass": { "chemical_mass": 134729.0, "monoisotopic_mass": 134729.0 }, "refseq": {}, "gene_names": [ { "name": "KCNH7", "type": "recommended", "evidence": [ { "id": "F1N4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ] } ], "protein_names": [ { "name": "Voltage-gated inwardly rectifying potassium channel KCNH2", "type": "recommended", "evidence": [ { "id": "F1N4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A4/entry#names_and_taxonomy" } ] }, { "name": "Ether-a-go-go-related gene potassium channel 1", "type": "synonym", "evidence": [ { "id": "F1N4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A4/entry#names_and_taxonomy" } ] }, { "name": "Potassium voltage-gated channel subfamily H member 2", "type": "synonym", "evidence": [ { "id": "F1N4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A4/entry#names_and_taxonomy" } ] }, { "name": "Voltage-gated potassium channel subunit Kv11.1", "type": "synonym", "evidence": [ { "id": "F1N4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSM4#function" }, { "database": "UniProtKB", "id": "ARBA00054598", "url": "https://www.uniprot.org/uniprotkb/ARBA00054598#function" }, { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNH7", "url": "https://www.uniprot.org/uniprotkb/F1N4A4", "locus": { "chromosome": "2", "start_pos": 34058050, "end_pos": 33528940, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001899", "url": "https://www.ensembl.org/id/ENSBTAG00000001899" } ] } } ], "crossref": [ { "id": "F1N4A4", "url": "https://alphafold.ebi.ac.uk/entry/F1N4A4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001899", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001899", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSM4", "url": "https://www.orthodb.org/?gene=A0A3Q1LSM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4A4", "url": "https://www.orthodb.org/?gene=F1N4A4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217:SF466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4A4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4A4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDVAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVRNEENAASPERVNPILPVKTVNRKLFGFKFPGLRVLTYRKQSLPQEDPDVVVIESSKHSDDSVAMKHLKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLTHSRSKESICSIRRASSVHDIEGFSVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSDVKAEKKNASPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLLRSQSVNDSEADHCKLRRRLSFDSEEDKGSTTNDPEDSVDTIRHYQSSKKHFEEKKSRSSSFISSIDDEQKPLFSGLADSPPGIGKATGLDLEETVPTSGRIHIDKRSHSCKDITDTRSWERENAGTQADESSPSALQRAAWGVSETESDLTYGEVEQRLDLLQEQLNRLESQMTADIQTILQLLQKQTTVVPPAYSMVTAGGEYQRPTIRLMRPRHPVASIKTDRTFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHPPRQRKTCLHPIRHPSLTDSSLSTVGVLGLHRHVSDPGLPGK", "length": 1197, "header": "tr|F1N4A4-1|F1N4A4_BOVIN Isoform 1 of Voltage-gated inwardly rectifying potassium channel KCNH2 OS=Bos taurus OX=9913 GN=KCNH7 PE=3 SV=3 CANONICAL=F1N4A4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSM4/entry", "sequence": { "sequence": "MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDVAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVRNEENAASPERVNPILPVKTVNRKLFGFKFPGLRVLTYRKQSLPQEDPDVVVIESSKHSDDSVAMKHLKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLTHSRSKESICSIRRASSVHDIEGFSVHPKNIFRDRHASEGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSDVKAEKKNASPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLLRSQSVNDSEADHCKLRRRLSFDSEEDKDFGKGSTTNDPEDSVDTIRHYQSSKKHFEEKKSRSSSFISSIDDEQKPLFSGLADSPPGIGKATGLDLEETVPTSGRIHIDKRSHSCKDITDTRSWERENAGTQADESSPSALQRAAWGVSETESDLTYGEVEQRLDLLQEQLNRLESQMTADIQTILQLLQKQTTVVPPAYSMVTAGGEYQRPTIRLMRPRHPVASIKTDRTFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHPPRQRKTCLHPIRHPSLTDSSLSTVGVLGLHRHVSDPGLPGK", "length": 1194, "header": "tr|A0A3Q1LSM4-1|F1N4A4_BOVIN Computationally mapped isoform of Voltage-gated inwardly rectifying potassium channel KCNH2 OS=Bos taurus OX=9913 GN=KCNH7 PE=3 SV=2 CANONICAL=F1N4A4-1" }, "locus": { "chromosome": "2", "start_pos": 34058047, "end_pos": 33529208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070249.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070249.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060260.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060260.2" } ] } }, { "isoform_ac": "F1N4A4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4A4/entry", "sequence": { "sequence": "MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDVAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVRNEENAASPERVNPILPVKTVNRKLFGFKFPGLRVLTYRKQSLPQEDPDVVVIESSKHSDDSVAMKHLKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLTHSRSKESICSIRRASSVHDIEGFSVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSDVKAEKKNASPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLLRSQSVNDSEADHCKLRRRLSFDSEEDKGSTTNDPEDSVDTIRHYQSSKKHFEEKKSRSSSFISSIDDEQKPLFSGLADSPPGIGKATGLDLEETVPTSGRIHIDKRSHSCKDITDTRSWERENAGTQADESSPSALQRAAWGVSETESDLTYGEVEQRLDLLQEQLNRLESQMTADIQTILQLLQKQTTVVPPAYSMVTAGGEYQRPTIRLMRPRHPVASIKTDRTFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHPPRQRKTCLHPIRHPSLTDSSLSTVGVLGLHRHVSDPGLPGK", "length": 1197, "header": "tr|F1N4A4-1|F1N4A4_BOVIN Isoform 1 of Voltage-gated inwardly rectifying potassium channel KCNH2 OS=Bos taurus OX=9913 GN=KCNH7 PE=3 SV=3 CANONICAL=F1N4A4-1" }, "locus": { "chromosome": "2", "start_pos": 34058047, "end_pos": 33529208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002469.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002469.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002469.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002469.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" }, { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" }, { "name": "inward rectifier potassium channel activity", "id": "GO:0005242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005242", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of membrane potential", "id": "GO:0042391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "F1N4A4", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1139, "end_pos": 1141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 882, "end_pos": 884, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4A4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4A4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4A4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A4" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 745, "end_pos": 845, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 1139, "end_pos": 1141 }, { "start_pos": 230, "end_pos": 232 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 348, "end_pos": 350 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 600, "end_pos": 602 }, { "start_pos": 632, "end_pos": 634 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 736, "end_pos": 738 }, { "start_pos": 882, "end_pos": 884 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4F6-1", "uniprot_ac": "F2Z4F6", "uniprot_id": "F2Z4F6_BOVIN", "mass": { "chemical_mass": 53329.0, "monoisotopic_mass": 53329.0 }, "refseq": {}, "gene_names": [ { "name": "SNX7", "type": "recommended", "evidence": [ { "id": "F2Z4F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ] } ], "protein_names": [ { "name": "Sorting nexin 7", "type": "synonym", "evidence": [ { "id": "F2Z4F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX7", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6", "locus": { "chromosome": "3", "start_pos": 44501681, "end_pos": 44620678, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031461", "url": "https://www.ensembl.org/id/ENSBTAG00000031461" } ] } } ], "crossref": [ { "id": "F2Z4F6", "url": "https://alphafold.ebi.ac.uk/entry/F2Z4F6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07284", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07284", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07666", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07666", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LHYYEEC", "url": "https://omabrowser.org/oma/group/LHYYEEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSX0", "url": "https://www.orthodb.org/?gene=A0A3Q1LSX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0T7", "url": "https://www.orthodb.org/?gene=A0A3Q1M0T7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F2Z4F6", "url": "https://www.orthodb.org/?gene=F2Z4F6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45949", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45949", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45949:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45949:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LSX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0T7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0T7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0T7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4F6-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKLGEAGLAATAGPARTLGMEGECRASQARSWGLPAGGAGGDSPGGDAPLPGSISSSSLLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPLMPTSPLSMINQVKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKEKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQASEFSSHKKQGPGLLSRMGQSVRAVALSMRGVKSRPEEFMEMNNFIEIFSQKINLIDKISQRIYKEEREYLDEMKEYGPIHILWSASEEDLADTLKSVASCIDKCCKATEKRMSGFSEALLPVVHEYVLYSEMLMAVMKRRDQIQAELDSKVEALTSKKADTDLLTEEIGKLEDKVECANNALKADWERWKQNMQNDIKSAFTNMAEENILYYEQCLATWESFLTSQTDLHLEEASEDKL", "length": 471, "header": "tr|F2Z4F6-1|F2Z4F6_BOVIN Isoform 1 of Sorting nexin 7 OS=Bos taurus OX=9913 GN=SNX7 PE=3 SV=3 CANONICAL=F2Z4F6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSX0/entry", "sequence": { "sequence": "MEGECRASQARSWGLPAGGAGGDSPGGDAPLPGSISSSSLLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPLMPTSPLSMINQVKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKEKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQASEFSSHKKQGPGLLSRMGQSVRAVALSMRGVKSRPEEFMEMNNFIEIFSQKINLIDKISQRIYKEEREYLDEMKEYGPIHILWSASEEDLADTLKSVASCIDKCCKATEKRMSGFSEALLPVVHEYVLYSEMLMLTEEIGKLEDKVECANNALKADWERWKQNMQNDIKSAFTNMAEENILYYEQCLATWESFLTSQTDLHLEEASEDKL", "length": 422, "header": "tr|A0A3Q1LSX0-1|F2Z4F6_BOVIN Computationally mapped isoform of Sorting nexin 7 OS=Bos taurus OX=9913 GN=SNX7 PE=3 SV=2 CANONICAL=F2Z4F6-1" }, "locus": { "chromosome": "3", "start_pos": 44620419, "end_pos": 44502038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085192.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085192.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060126.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060126.2" } ] } }, { "isoform_ac": "A0A3Q1M0T7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0T7/entry", "sequence": { "sequence": "MEGECRASQARSWGLPAGGAGGDSPGGDAPLPGSISSSSLLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPLMPTSPLSMINQVKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKEKLEEAHPTLIIPEFSSHKKQGPGLLSRMGQSVRAVALSMRGVKSRPEEFMEMNNFIEIFSQKINLIDKISQRIYKEEREYLDEMKEYGPIHILWSASEEDLADTLKSVASCIDKCCKATEKRMSGFSEALLPVVHEYVLYSEMLMAVMKRRDQIQAELDSKVEALTSKKADTDLLTEEIGKLEDKVECANNALKADWERWKQNMQNDIKSAFTNMAEENILYYEQCLATWESFLTSQTDLHLEEASEDKL", "length": 396, "header": "tr|A0A3Q1M0T7-1|A0A3Q1M0T7_BOVIN Computationally mapped isoform of Sorting nexin 7 OS=Bos taurus OX=9913 GN=SNX7 PE=3 SV=2 CANONICAL=F2Z4F6-1" }, "locus": { "chromosome": "3", "start_pos": 44620419, "end_pos": 44502038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075082.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075082.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063602.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063602.2" } ] } }, { "isoform_ac": "A0AAA9SAS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS9/entry", "sequence": { "sequence": "MGKLGEAGLAATAGPARTLGMEGECRASQARSWGLPAGGAGGDSPGGDAPLPGSISSSSLLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPLMPTSPLSMINQVKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKEKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQASEFSSHKKQGPGLLSRMGQSVRAVALSMRGVKSRPEEFMEMNNFIEIFSQKINLIDKISQRIYKEEREYLDEMKEYGPIHILWSASEEDLADTLKSVASCIDKCCKATEKRMSGFSEALLPVVHEYVLYSEMLMAVMKRRDQIQAELDSKVEALTSKKADTDLLTEEIGKLEDKVECANNALKADWERWKQNMQNDIKSAFTNMAEENILYYEQFSIRSP", "length": 452, "header": "tr|A0AAA9SAS9-1|F2Z4F6_BOVIN Computationally mapped isoform of Sorting nexin 7 OS=Bos taurus OX=9913 GN=SNX7 PE=3 SV=1 CANONICAL=F2Z4F6-1" }, "locus": { "chromosome": "3", "start_pos": 44620479, "end_pos": 44502929, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111484.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111484.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083199.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083199.1" } ] } }, { "isoform_ac": "F2Z4F6-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6/entry", "sequence": { "sequence": "MGKLGEAGLAATAGPARTLGMEGECRASQARSWGLPAGGAGGDSPGGDAPLPGSISSSSLLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPLMPTSPLSMINQVKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKEKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQASEFSSHKKQGPGLLSRMGQSVRAVALSMRGVKSRPEEFMEMNNFIEIFSQKINLIDKISQRIYKEEREYLDEMKEYGPIHILWSASEEDLADTLKSVASCIDKCCKATEKRMSGFSEALLPVVHEYVLYSEMLMAVMKRRDQIQAELDSKVEALTSKKADTDLLTEEIGKLEDKVECANNALKADWERWKQNMQNDIKSAFTNMAEENILYYEQCLATWESFLTSQTDLHLEEASEDKL", "length": 471, "header": "tr|F2Z4F6-1|F2Z4F6_BOVIN Isoform 1 of Sorting nexin 7 OS=Bos taurus OX=9913 GN=SNX7 PE=3 SV=3 CANONICAL=F2Z4F6-1" }, "locus": { "chromosome": "3", "start_pos": 44620479, "end_pos": 44502038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044574.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044574.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042058.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042058.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IBS8-1", "protein_name": "Sorting nexin-7 isoform X1", "gene_name": "snx7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVPAVDNTVSSGNASVAIPADMSGQMLDLDEDDDLEVFSKDTTITDGSSFNASMQTSPASMINQYKFEEEEEDVGTKDIFVTVDNPESHVTAIETYITYRVMTKTTRSEFDSSEFEVRRRYQDFLWLKGRLEEAHPTLIVHPLPEKFVMKGMVERFNEDFIETRRRALHRFLNRIAEHPIFSSTEDFKIFLTAASEELISHKKQGPGFLSRMGETVKAVAASVRGVRNRPEEFNDMQEYVEAFSQKINSLDKVTQRIIREQREYLEELKECGPTYTLWSNSEQELAEPLKNMADCLDRCYKETDEQVKQLNDQLSPALHEYVLCTETLKAVIRRRDNIQADFEAKTEALATKKADREADSKVLSLAWDSLVGRSPEEVKQQRQQKLKAEIKEMKDDLEKLEDRLEWANNALKSDWTRWNKVMRTDLRSAFVDTAERNVSYYEKCLAIWESFLHSQRTDAEANGKADFS", "length": 469 }, "evidence": [ { "id": "F2Z4F6", "url": "https://omabrowser.org/oma/group/F2Z4F6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F7EXP7-1", "protein_name": "Sorting nexin 7", "gene_name": "Snx7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPATSHTNLVALSCVSARTPPPVLWVSIAHPGGVPRVRISSPAADQSQVRVRQAPQLSRPARAPRAPAVPRLRTAEGQELGWPGRRRAPREPMGARGGAGLAAAAGWARTAGMDGERLASGSSELAVGESPRGGAPIPSGSGSCSLLQADVLDLDEEEDDLEVFSKDASLMDMNSFSPMMPTSPLSMINQIKFEDGPDLKDLFITVDAPESHVTTIETFITYRIVTKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKVFLTAEAWELSSYKKQGPGLLSRMGQTVRAVASSMRGVKNRPDEFTEMNNFIETFSQKINLIDKISQRIYKEERDYFDEMKEYGPIHTLWSTSEEDLVDTLKGIASCIDQCCKATEKRMSGLSEALLPVVHEYVLYSEMLVGVMKRRDQIQAELDSKVEALTYKKADADLLTEEIGKLEDKVECANNALKADWERWRQNMQNDLRSAFTDTAEENIRYYEQCLATWESFLTSQTDLPLEEDPEDKL", "length": 558 }, "evidence": [ { "id": "F2Z4F6", "url": "https://omabrowser.org/oma/group/F2Z4F6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CY18-1", "protein_name": "Sorting nexin-7", "gene_name": "Snx7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDMNSFSPMMPTSPLSMINQIKFEDGPDLKDLFITVDAPESHVTTIETFITYRIVTKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKVFLTAQAEELSSYKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIETFSQKINLIDKISQRIYKEERDYFDEMKEYGPIHILWSASEEELVDTLKGMAGCIEQCCKATEKRMAGLSEALLPVVHEYVLYSEMLVGVMKRRDQIQTELDSKVEALTYKKADIDLLTEEIGKLEDKVECANNALKADWERWKQNMKNDLRSAFTDTAEQNIRYYEQCLATWESFLTSQTDLPSEEDSEEKL", "length": 387 }, "evidence": [ { "id": "F2Z4F6", "url": "https://omabrowser.org/oma/group/F2Z4F6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UNH6-1", "protein_name": "Sorting nexin-7", "gene_name": "SNX7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIKLAFTDMAEENIHYYEQCLATWESFLTSQTNLHLEEASEDKP", "length": 387 }, "evidence": [ { "id": "F2Z4F6", "url": "https://omabrowser.org/oma/group/F2Z4F6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "positive regulation of autophagosome assembly", "id": "GO:2000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000786", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" }, { "name": "phagophore assembly site", "id": "GO:0000407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000407", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "F2Z4F6", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F2Z4F6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 471, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F2Z4F6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F2Z4F6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F2Z4F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4F6" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 235, "start_aa": "Lys", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2Y2-1", "uniprot_ac": "F1N2Y2", "uniprot_id": "F1N2Y2_BOVIN", "mass": { "chemical_mass": 144959.0, "monoisotopic_mass": 144959.0 }, "refseq": {}, "gene_names": [ { "name": "COL5A2", "type": "recommended", "evidence": [ { "id": "F1N2Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ] } ], "protein_names": [ { "name": "Collagen type V alpha 2 chain", "type": "synonym", "evidence": [ { "id": "F1N2Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL5A2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2", "locus": { "chromosome": "2", "start_pos": 7357604, "end_pos": 7198368, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027020", "url": "https://www.ensembl.org/id/ENSBTAG00000027020" } ] } } ], "crossref": [ { "id": "ENSBTAG00000027020", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027020", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1109", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1109", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LSX2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSX2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2Y2-1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMANWVEARPLLILTVLLGQFVSIKAQEEDEDEGYGEEIACTQNGQMYLNRDIWKPAPCQICVCDNGAILCDKIQCQDVLECADPVTPPGECCPVCPHTTGGGNTNFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGERGPKGKPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGVGPAGPPGEPGDPGPMGPVGARGPEGPPGKPGEDGEPGRNGKPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGATGSKGEAGPTGPMGAMGPMGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSAGFPGNPGMKGEAGPTGARGPEGPQGQRGETGPPGPVGSQGLPGAVGTDGTPGAKGPTGSPGTSGPPGLAGPPGSPGPQGSTGPPGIRGQPGDPGVPGFKGEAGPKGEPGPHGVQGPIGPPGEEGKRGPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEAGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPPGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPSGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGAPGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLLGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPTGEQGSAGIPGPFGPRGPPGPVGPSGKEGSPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDDSMPDPLPEFTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSRKHPARTCDDLKLCHSAKKSGEYWIDPNQGSAEDAIKVYCNMETGETCISANPSSVPRKTWWASKSPDNKPVWYGLDMNRGSQFVYGDHQSPNAAITQMTFLRLLSKEASQNITYICKNSVGYMDDQAKNLKKAVVLKGSNDLEIKAEGNVRFRYIVLHDSCSKRNGNVGKTIFEYRTQNVARLPIIDLAPVDVGSTDQEFGVEIGPVCFV", "length": 1499, "header": "tr|F1N2Y2-1|F1N2Y2_BOVIN Isoform 1 of Collagen type V alpha 2 chain OS=Bos taurus OX=9913 GN=COL5A2 PE=4 SV=4 CANONICAL=F1N2Y2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSX2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSX2/entry", "sequence": { "sequence": "MMANWVEARPLLILTVLLGQFVSIKAQEEDEDEGYGEEIACTQNGQMYLNRDIWKPAPCQICVCDNGAILCDKIQCQDVLECADPVTPPGECCPVCPHTTGGGNTNFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGERGPKGKPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGVGPAGPPGEPGDPGPMGPVGARGPEGPPGKPGEDGEPGRNGKPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGATGSKGEAGPTGPMGDPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEAGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPPGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPSGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGAPGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLLGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPTGEQGSAGIPGPFGPRGPPGPVGPSGKEGSPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDDSMPDPLPEFTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSRKHPARTCDDLKLCHSAKKSGEYWIDPNQGSAEDAIKVYCNMETGETCISANPSSVPRKTWWASKSPDNKPVWYGLDMNRGSQFVYGDHQSPNAAITQMTFLRLLSKEASQNITYICKNSVGYMDDQAKNLKKAVVLKGSNDLEIKAEGNVRFRYIVLHDSCSKRNGNVGKTIFEYRTQNVARLPIIDLAPVDVGSTDQEFGVEIGPVCFV", "length": 1322, "header": "tr|A0A3Q1LSX2-1|F1N2Y2_BOVIN Computationally mapped isoform of Collagen type V alpha 2 chain OS=Bos taurus OX=9913 GN=COL5A2 PE=4 SV=2 CANONICAL=F1N2Y2-1" }, "locus": { "chromosome": "2", "start_pos": 7357284, "end_pos": 7198509, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073698.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073698.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060389.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060389.2" } ] } }, { "isoform_ac": "F1N2Y2-1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2/entry", "sequence": { "sequence": "MMANWVEARPLLILTVLLGQFVSIKAQEEDEDEGYGEEIACTQNGQMYLNRDIWKPAPCQICVCDNGAILCDKIQCQDVLECADPVTPPGECCPVCPHTTGGGNTNFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGERGPKGKPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGVGPAGPPGEPGDPGPMGPVGARGPEGPPGKPGEDGEPGRNGKPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEVGATGSKGEAGPTGPMGAMGPMGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLGIPGSAGFPGNPGMKGEAGPTGARGPEGPQGQRGETGPPGPVGSQGLPGAVGTDGTPGAKGPTGSPGTSGPPGLAGPPGSPGPQGSTGPPGIRGQPGDPGVPGFKGEAGPKGEPGPHGVQGPIGPPGEEGKRGPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEAGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPPGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPSGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGAPGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLLGPQGPRGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPTGEQGSAGIPGPFGPRGPPGPVGPSGKEGSPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDDSMPDPLPEFTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSRKHPARTCDDLKLCHSAKKSGEYWIDPNQGSAEDAIKVYCNMETGETCISANPSSVPRKTWWASKSPDNKPVWYGLDMNRGSQFVYGDHQSPNAAITQMTFLRLLSKEASQNITYICKNSVGYMDDQAKNLKKAVVLKGSNDLEIKAEGNVRFRYIVLHDSCSKRNGNVGKTIFEYRTQNVARLPIIDLAPVDVGSTDQEFGVEIGPVCFV", "length": 1499, "header": "tr|F1N2Y2-1|F1N2Y2_BOVIN Isoform 1 of Collagen type V alpha 2 chain OS=Bos taurus OX=9913 GN=COL5A2 PE=4 SV=4 CANONICAL=F1N2Y2-1" }, "locus": { "chromosome": "2", "start_pos": 7357284, "end_pos": 7198509, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038684.7", "url": "https://www.ensembl.org/id/ENSBTAT00000038684.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038495.6", "url": "https://www.ensembl.org/id/ENSBTAP00000038495.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1015, "start_aa": "Thr", "end_pos": 1015, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1015", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1022, "start_aa": "Thr", "end_pos": 1022, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1022", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1057, "start_aa": "Thr", "end_pos": 1057, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1057", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1087, "start_aa": "Thr", "end_pos": 1087, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1087", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1160, "start_aa": "Thr", "end_pos": 1160, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1160", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 326, "start_aa": "Thr", "end_pos": 326, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr326", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 392, "start_aa": "Thr", "end_pos": 392, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr392", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 427, "start_aa": "Thr", "end_pos": 427, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr427", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 434, "start_aa": "Thr", "end_pos": 434, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr434", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 751, "start_aa": "Thr", "end_pos": 751, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr751", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 772, "start_aa": "Thr", "end_pos": 772, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr772", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 812, "start_aa": "Thr", "end_pos": 812, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr812", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 842, "start_aa": "Thr", "end_pos": 842, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr842", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 87, "start_aa": "Thr", "end_pos": 87, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr87", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" }, { "name": "collagen type V trimer", "id": "GO:0005588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005588", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" }, { "name": "SMAD binding", "id": "GO:0046332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" }, { "name": "skin development", "id": "GO:0043588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043588", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" }, { "name": "eye morphogenesis", "id": "GO:0048592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048592", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" }, { "name": "negative regulation of endodermal cell differentiation", "id": "GO:1903225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903225", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1262, "end_pos": 1264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" }, { "id": "PS51461", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51461" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrillar collagen NC1", "eco_id": "ECO_0000259", "start_pos": 1266, "end_pos": 1499, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y2" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 97, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 87, 326, 392, 427, 434, 751, 772, 812, 842, 1015, 1022, 1057, 1087, 1160 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1262, "end_pos": 1264 }, { "start_pos": 1400, "end_pos": 1402 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 14 }, { "field": "total_sites", "count": 14 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 14 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 14 }, { "field": "exact_o_linked_sites", "count": 14 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 14 }, { "field": "total_sites", "count": 14 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 14 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 14 }, { "field": "exact_o_linked_sites", "count": 14 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QKN4-1", "uniprot_ac": "F6QKN4", "uniprot_id": "F6QKN4_BOVIN", "mass": { "chemical_mass": 108198.0, "monoisotopic_mass": 108198.0 }, "refseq": { "ac": "XP_005204566", "name": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204566" }, "gene_names": [ { "name": "KANK4", "type": "recommended", "evidence": [ { "id": "F6QKN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QKN4" } ] }, { "name": "KANK4", "type": "synonym", "evidence": [ { "id": "XP_005204566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204566" } ] } ], "protein_names": [ { "name": "KN motif and ankyrin repeat domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "F6QKN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QKN4/entry#names_and_taxonomy" } ] }, { "name": "Ankyrin repeat domain-containing protein 38", "type": "synonym", "evidence": [ { "id": "F6QKN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QKN4/entry#names_and_taxonomy" } ] }, { "name": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204566" } ] } ], "function": [ { "annotation": "May be involved in the control of cytoskeleton formation by regulating actin polymerization.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTJ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ0#function" }, { "database": "UniProtKB", "id": "ARBA00059781", "url": "https://www.uniprot.org/uniprotkb/ARBA00059781#function" }, { "database": "UniProtKB", "id": "F6QKN4", "url": "https://www.uniprot.org/uniprotkb/F6QKN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QKN4", "url": "https://www.uniprot.org/uniprotkb/F6QKN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KANK4", "url": "https://www.uniprot.org/uniprotkb/F6QKN4", "locus": { "chromosome": "3", "start_pos": 83334028, "end_pos": 83292167, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014382", "url": "https://www.ensembl.org/id/ENSBTAG00000014382" } ] } } ], "crossref": [ { "id": "F6QKN4", "url": "https://alphafold.ebi.ac.uk/entry/F6QKN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014382", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014382", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519027", "url": "https://www.ncbi.nlm.nih.gov/gene/519027", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QSCQGDE", "url": "https://omabrowser.org/oma/group/QSCQGDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6QKN4", "url": "https://www.orthodb.org/?gene=F6QKN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24168", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24168", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24168:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24168:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12075", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12075", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204566", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTJ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QKN4", "url": "https://www.uniprot.org/uniprotkb/F6QKN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QKN4-1", "url": "https://www.uniprot.org/uniprotkb/F6QKN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGARPHAVLSHPNWSPMVSRKVLGTEARAQPLPLGDHPQAPQAASGSEVSYHRKALLMETARQLEAAAAPGEAELTSGSGRPQLLRASSMPATLLQTRASEDPSLNSGPPTPPVLPPLQGEDVVCDGAFGPAEGFAGFSNFTPRAATQPEVRESGDLVPGIPELIQEGPEPPESEKEAPNHLSFPSPPFLSQNALVVLEDAEDQQESREAQVVVTTPSSPTPSPPPLPSPIPENELPLEEIELNISEIPPPPPVEVDVRSVGIRVTEESLGLASLDPGSISCLKQQISDLEGELSGRTEELAQVRAALQRQEEEIKAKGQRIQELECTVAQLVEKLSGGNTKDAQGQTDAMVNTDPLQGLLTRQSCDKSIGVSLLGSMGSESWGARGEGNGLLWGWESHKRGDGSPAGLVSPPQPSLPQGSETVLMPSLHSCLSTELRIEEGGSEQAGGPSVGIKGLDRGVGGSPGSGERKAPPAGREEAGPELSGKERLGRPPSSPTDATIGQYVKKIQELLQEQWSCLEHGYPELARAIKQPASKLSSIQSQLQSSLNLLLSAYSAQAPPQKEPPGPSSSPTMEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSSPEDLSDSEAEKKCDGPEPRRGKDAHLSCRVGQGTPEGTRDTDQETGPGEELPHPRTERYKPSEEFLNACRVLSQHLPETGTTTDQLLKQSLNTISQEWFRISSRKSSSPAVVASYLHGVQPHSPHLLKLLVNLADGNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETDEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDRGDMVQALLSCQADVNLQDHDGSSALMLACCHGNTDMVRLLLAHPTCDSSLTDKAGQTALSIALKSPAHVEIAGLLRAHLKQGRSLGP", "length": 1014, "header": "tr|F6QKN4-1|F6QKN4_BOVIN Isoform 1 of KN motif and ankyrin repeat domain-containing protein 4 OS=Bos taurus OX=9913 GN=KANK4 PE=4 SV=2 CANONICAL=F6QKN4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ0/entry", "sequence": { "sequence": "MEKTDEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSSPEDLSDSEAEKKCDGPEPRRGKDAHLSCRVGQGTPEGTRDTDQETGPGEELPHPRTERYKPSEEFLNACRVLSQHLPETGTTTDQLLKQSLNTISQEWFRISSRKSSSPAVVASYLHGVQPHSPHLLKLLVNLADGNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETDEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDRGDMVQALLSCQADVNLQDHDGSSALMLACCHGNTDMVRLLLAHPTCDSSLTDKAGQTALSIALKSPAHVEIAGLLRAHLKQGRSLGP", "length": 367, "header": "tr|A0A3Q1LTJ0-1|F6QKN4_BOVIN Computationally mapped isoform of KN motif and ankyrin repeat domain-containing protein 4 OS=Bos taurus OX=9913 GN=KANK4 PE=4 SV=1 CANONICAL=F6QKN4-1" }, "locus": { "chromosome": "3", "start_pos": 83332027, "end_pos": 83298429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082492.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082492.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060642.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060642.2" } ] } }, { "isoform_ac": "F6QKN4-1", "url": "https://www.uniprot.org/uniprotkb/F6QKN4/entry", "sequence": { "sequence": "MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGARPHAVLSHPNWSPMVSRKVLGTEARAQPLPLGDHPQAPQAASGSEVSYHRKALLMETARQLEAAAAPGEAELTSGSGRPQLLRASSMPATLLQTRASEDPSLNSGPPTPPVLPPLQGEDVVCDGAFGPAEGFAGFSNFTPRAATQPEVRESGDLVPGIPELIQEGPEPPESEKEAPNHLSFPSPPFLSQNALVVLEDAEDQQESREAQVVVTTPSSPTPSPPPLPSPIPENELPLEEIELNISEIPPPPPVEVDVRSVGIRVTEESLGLASLDPGSISCLKQQISDLEGELSGRTEELAQVRAALQRQEEEIKAKGQRIQELECTVAQLVEKLSGGNTKDAQGQTDAMVNTDPLQGLLTRQSCDKSIGVSLLGSMGSESWGARGEGNGLLWGWESHKRGDGSPAGLVSPPQPSLPQGSETVLMPSLHSCLSTELRIEEGGSEQAGGPSVGIKGLDRGVGGSPGSGERKAPPAGREEAGPELSGKERLGRPPSSPTDATIGQYVKKIQELLQEQWSCLEHGYPELARAIKQPASKLSSIQSQLQSSLNLLLSAYSAQAPPQKEPPGPSSSPTMEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSSPEDLSDSEAEKKCDGPEPRRGKDAHLSCRVGQGTPEGTRDTDQETGPGEELPHPRTERYKPSEEFLNACRVLSQHLPETGTTTDQLLKQSLNTISQEWFRISSRKSSSPAVVASYLHGVQPHSPHLLKLLVNLADGNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETDEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDRGDMVQALLSCQADVNLQDHDGSSALMLACCHGNTDMVRLLLAHPTCDSSLTDKAGQTALSIALKSPAHVEIAGLLRAHLKQGRSLGP", "length": 1014, "header": "tr|F6QKN4-1|F6QKN4_BOVIN Isoform 1 of KN motif and ankyrin repeat domain-containing protein 4 OS=Bos taurus OX=9913 GN=KANK4 PE=4 SV=2 CANONICAL=F6QKN4-1" }, "locus": { "chromosome": "3", "start_pos": 83332027, "end_pos": 83298429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019125.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019125.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019125.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019125.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 188, "start_aa": "Thr", "end_pos": 188, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr188", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 298, "start_aa": "Thr", "end_pos": 298, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr298", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZP92-1", "protein_name": "KN motif and ankyrin repeat domain-containing protein 4", "gene_name": "KANK4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEKTDAAGQPPLPNGDGEQPRSLPYSLETPYGFHLDLDFLKYVDDIEKGNTIRRVHIHRKAKQPKFSTLPRNFSLPENGSHGYAASTGPGWPAATYRAQRKASLGAEEISRAPLPSEEPSYRRKALLAETRRHAELVRCEDELRGRPQLLRASSLPAALPPGQAPASDGCVPCPLLPSDNGSCPESTFRPMPRSPDGIASLPSLMLSPGAELASQQQEWPGKGGLVRDVPKERAQPLWQGQHSAVQLQVVMESRGEEGDASDATNGSTLVSASPGALQLADESTNHGKAGGSVSEIALNVLKEGEGRCAHAQEKKEQGGDAGEPGGIAALKQHIAALEEQLDRKKEELEQIRAVLKQQDHKIKEKEKSIQLLASSKAQLEEQLCRENTREDAVSSMQRGSMLQCNDVAVNTELSYVNGSKQVHDKGINVNIPLSTKSIGCGIRRADNGNLLAAELSAQGWADVGTSGGGDGHFAKLSETEAGLEPGLHAPGFTELKIDEQLSDDNQNQRNSCDTQSLAARAAAAESYRTKRTGSSADENEAGFGEDKTEDGMGEEGLPDPKDFPAVDPIGQYVKKIQELLQEQWMCLEHGYPELASAIKQPASKLSSIQNQLVNSLNSLLSAYSSQRPADKENSNTHYQQLETSSTTSLKSIMKKKGYGSHAGGNGTKKNLQFVGVNGGYETTSSEDTSCEDSPSDGDMESDTERGAGGLEPTQEQGGGGSEGASFVTSVQETREDDDLQEPGAETAPCTQHKADSCKPSEDFLAACQLLSQHLSEIRATSDQHLRHVLSTICQEWFQVSSRKSSSPEVVTAYLQALGTIQPQLLEAVVNMADRNGNTALHYSISHSNFTIAKLLLDTGVCRLDLPNQAGYTAVMLTPLVAAETDEDMAVVMRLLKEGDVNVRAAQGGQTALMLGVSHEREAMVRALLACHADVNLQDEQGSTALMVACRQGSTDMVRLLLAQPGCQLALTDKDGDTALSIAQRSAHEDIAALLHSAQHGPND", "length": 1003 }, "evidence": [ { "id": "F6QKN4", "url": "https://omabrowser.org/oma/group/F6QKN4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A6X3-1", "protein_name": "KN motif and ankyrin repeat domain-containing protein 4", "gene_name": "Kank4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKMDGRQFLSPDLKAKDQSPQGDEEKEPPKSYPYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRAKQAKFSTLPRNFSLPNSGDRSHAAPPQQNWSPVVPRKISLGTQEQSQSVPLGDLPQATVHGNELSYHRKALLAKDTRQVEAGSLEDAGSGRPQLLRASSMPATLPQNQAPEVPNLTSGPSALLVLPPLQDEGSVRDGTFDPAEGLMGFQAAAQSTDRAVEELEPAIPEPVWEGAEPEEGDIKAASHLSQPAPSSSVQNVSVDLEEVDIQHHTRTADLALSPGSSTPSPPPLPSPIPENELSLEEIELNISEIPPPPPIEVDVRSVGVRVTEESLGLVETATSSISSLKSQVLDLEDKLSGRTEELAQVRAALEQQEEETKAREQRIQELECTVAHLEEKLSQEKASDALDRTDAMVNTDPLRELIPRESQDKNIGVNLLSTPVPECWASRAEKNGFPWVQTNHKQSYPSPEEPALPPQLSLPRGPEQILASSLCSCLSMELRIEEEVSEQERDPDGGAGSLSREAGGSPWSRRESAPVIREEASSQLPGAERPGRPASSPQDATIGQYVKKIQELLHEQWNCLEHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEPKESPVPPSSTPPPPPEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEDTSGEDSSPEDLSDSETEKKQDCSEPREDRDMHLSCEAGQGVSKGTGNSGHMSEPRKGVSHMKAERYKPSEEFLNACQALSQHLPEAGATNKQLLRQSLNTISQEWFRVSSRKLSSPEAVAACLLEVQPQSPHLLKLLVNLADRSGNTALHYSVSHSNFAIAKLLLDTGVCNVDHQNKAGYTAVMITPLASPKTKEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCKADVNLQDHDGSSALMLACHQGNADLVRLLLAHADCNSNLTDKAGQTALSIVLNSPAHVEIAELLRAHSEQGRSLGLKELQKN", "length": 1020 }, "evidence": [ { "id": "F6QKN4", "url": "https://omabrowser.org/oma/group/F6QKN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T7N3-1", "protein_name": "KN motif and ankyrin repeat domain-containing protein 4", "gene_name": "KANK4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL", "length": 995 }, "evidence": [ { "id": "F6QKN4", "url": "https://omabrowser.org/oma/group/F6QKN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P9J5-1", "protein_name": "KN motif and ankyrin repeat domain-containing protein 4", "gene_name": "Kank4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKIDGKDQSSQGDEEKEPPKSYPYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRAKQAKFSTLPRNFSLPNSGDRTYAVPPQQNWSPVVPRKISLGTQEPSQPLPLGDLPQASVQGSELNYHRKALLAKDARQAEAGSLEDVGSGRPQLLRASSMPATLLQNQVPEEPSLTSGPSTLLALPLLQDEGSVCDGAFDPAEGLMGFQASAQSVDRELGELEPAIPEQVWEGAEPEEGDLKASSHLSQPGPSSAVQSVPMDLEEVEIEHHMREAELVLTPGSATPSPPPLPSPILENDLSLDEIELSISEIPPPPPIEVDVRSIGIRVTEESLGLLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQEEETKAREQRIQELECTVAHLEEKLSQERASEAPDRTDATVNTDPLQELTPRESHDKNIGVNLLNTPDPECRAPRAEKNGFPWVQNNHKQSYPSPEEPVLPPQLSLPRGPEQILASSLCSCLSMELRIEEEGSEQEGGQEEGAGGLSRAAGESSWSTRESAPVIREEATSELPGAERPGRPASSPQDATIGQYVKKIQELLHEQWNCLEHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEPEPKETPAPPPSTPPPPPPPPPEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSSPEDLSDSETEKKQDCSESREDRDLHPSCEAGQGVPEGTRNSGHTSDRGEEVSHLRAERYKPSEEFLNACQTLSQHLPETGDTTKQLLRQSLNTISQEWFRVSSRKLSSPEAVAAYLLEVQPHSPYLLKLLVNLADRSGNTALHYSVSHSNFAIVKLLLDTGVCNVDHQNKAGYTAVMITPLASAETKEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDNDGSSALMLACHQGNADLVRLLLAHPACNSSLTDKAGRTALSLVLNSPAHVEIAELLRAHSEPGRSLGPKELQKN", "length": 1016 }, "evidence": [ { "id": "F6QKN4", "url": "https://omabrowser.org/oma/group/F6QKN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F6QKN4", "url": "https://www.uniprot.org/uniprotkb/F6QKN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of actin filament polymerization", "id": "GO:0030837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837", "evidence": [ { "database": "UniProtKB", "id": "F6QKN4", "url": "https://www.uniprot.org/uniprotkb/F6QKN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 855, "end_pos": 857, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QKN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1014, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QKN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QKN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 188, 298 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 855, "end_pos": 857 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6S8-1", "uniprot_ac": "F1N6S8", "uniprot_id": "F1N6S8_BOVIN", "mass": { "chemical_mass": 131904.0, "monoisotopic_mass": 131904.0 }, "refseq": {}, "gene_names": [ { "name": "SRCIN1", "type": "recommended", "evidence": [ { "id": "F1N6S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ] } ], "protein_names": [ { "name": "SRC kinase signaling inhibitor 1", "type": "synonym", "evidence": [ { "id": "F1N6S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6S8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRCIN1", "url": "https://www.uniprot.org/uniprotkb/F1N6S8", "locus": { "chromosome": "19", "start_pos": 39148784, "end_pos": 39219803, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013469", "url": "https://www.ensembl.org/id/ENSBTAG00000013469" } ] } } ], "crossref": [ { "id": "F1N6S8", "url": "https://alphafold.ebi.ac.uk/entry/F1N6S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013469", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013469", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR022782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVB1", "url": "https://www.orthodb.org/?gene=A0A3Q1LVB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ME33", "url": "https://www.orthodb.org/?gene=A0A3Q1ME33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N5E1", "url": "https://www.orthodb.org/?gene=A0A3Q1N5E1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N6S8", "url": "https://www.orthodb.org/?gene=F1N6S8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22741", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22741", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22741:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22741:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03915", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03915", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LVB1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVB1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME33", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME33-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5E1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5E1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5E1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5E1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6S8-1", "url": "https://www.uniprot.org/uniprotkb/F1N6S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGGSKRGRGLGPLSPPQEKFGREGTGQRTREREVASNQDGRRGQSHLEKSVEPTDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAPSGAGQPAQTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAPGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGPLYGDGYGFRLPPSSPQKLADVTAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSTGGSSTAGAPPPELFPGPGERPLVGFGPPAPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGSRSSGATPVSGPPPPPASSTPAGQPTAINRLQMQLHLRGLQNSTNDLRSQLQQLRKLQLQNLESLRALLKGTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPSNLLSQSPKKMTAETDFNKSLDFEMPPPSPPLNLHELSGPTEGAPPAPKAGNPTKGLDTPGKRSMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKTPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRTVSEVARPASTPPIMASAIKDEDDEDRIIAELEVFERSSVSPLPPTPRRQPIPTLLSPPDLGPPRASAPGPTWKVTGCPHLSQRSLCLCLHASSPHFSR", "length": 1225, "header": "tr|F1N6S8-1|F1N6S8_BOVIN Isoform 1 of SRC kinase signaling inhibitor 1 OS=Bos taurus OX=9913 GN=SRCIN1 PE=4 SV=4 CANONICAL=F1N6S8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVB1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVB1/entry", "sequence": { "sequence": "MRSAWVHLHSGAASGLRPCLCGTSGTPEGSPSPGWWGGPDTKGGVSFAGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAPGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGPLYGDGYGFRLPPSSPQKLADVTAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSTGGSSTAGAPPPELFPGPGERPLVGFGPPAPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGSRSSGATPVSGPPPPPASSTPAGQPTAINRLQMQLHLRGLQNSTNDLRSQLQQLRKLQLQNLESLRALLKGTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPSNLLSQSPKKMTAETDFNKSLDFEMPPPSPPLNLHELSGPTEGAPPAPKAGNPTKGLDTPGKRSMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKTPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRTVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKTAQGQAGSPDKGKHGKQRAEYMRIQAQQQIK", "length": 1004, "header": "tr|A0A3Q1LVB1-1|F1N6S8_BOVIN Computationally mapped isoform of SRC kinase signaling inhibitor 1 OS=Bos taurus OX=9913 GN=SRCIN1 PE=4 SV=2 CANONICAL=F1N6S8-1" }, "locus": { "chromosome": "19", "start_pos": 39178819, "end_pos": 39157396, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087318.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087318.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059219.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059219.2" } ] } }, { "isoform_ac": "A0A3Q1ME33-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME33/entry", "sequence": { "sequence": "MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAPSGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAPGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGPLYGDGYGFRLPPSSPQKLADVTAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSTGGSSTAGAPPPELFPGPGERPLVGFGPPAPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGSRSSGATPVSGPPPPPASSTPAGQPTAINRLQMQLHLRGLQNSTNDLRSQLQQLRKLQLQNLESLRALLKGTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPSNLLSQSPKKMTAETDFNKSLDFEMPPPSPPLNLHELSGPTEGAPPAPKAGNPTKGLDTPGKRSMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKTPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRTVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKTAQGQAGSPDKGKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF", "length": 1212, "header": "tr|A0A3Q1ME33-1|F1N6S8_BOVIN Computationally mapped isoform of SRC kinase signaling inhibitor 1 OS=Bos taurus OX=9913 GN=SRCIN1 PE=4 SV=2 CANONICAL=F1N6S8-1" }, "locus": { "chromosome": "19", "start_pos": 39218462, "end_pos": 39149788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071143.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071143.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068731.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068731.2" } ] } }, { "isoform_ac": "A0A3Q1N5E1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5E1/entry", "sequence": { "sequence": "MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAPGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGPLYGDGYGFRLPPSSPQKLADVTAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSTGGSSTAGAPPPELFPGPGERPLVGFGPPAPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGSRSSGATPVSGPPPPPASSTPAGQPTAINRLQMQLHLRGLQNSTNDLRSQLQQLRKLQLQNLESLRALLKGTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPSNLLSQSPKKMTAETDFNKSLDFEMPPPSPPLNLHELSGPTEGAPPAPKAGNPTKGLDTPGKRSMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKTPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRTVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKTAQGQAGSPDKGKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF", "length": 1178, "header": "tr|A0A3Q1N5E1-1|F1N6S8_BOVIN Computationally mapped isoform of SRC kinase signaling inhibitor 1 OS=Bos taurus OX=9913 GN=SRCIN1 PE=4 SV=2 CANONICAL=F1N6S8-1" }, "locus": { "chromosome": "19", "start_pos": 39218462, "end_pos": 39149788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067711.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067711.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065377.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065377.2" } ] } }, { "isoform_ac": "F1N6S8-1", "url": "https://www.uniprot.org/uniprotkb/F1N6S8/entry", "sequence": { "sequence": "MPGGSKRGRGLGPLSPPQEKFGREGTGQRTREREVASNQDGRRGQSHLEKSVEPTDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSAPSGAGQPAQTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAPGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGPLYGDGYGFRLPPSSPQKLADVTAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSTGGSSTAGAPPPELFPGPGERPLVGFGPPAPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGSRSSGATPVSGPPPPPASSTPAGQPTAINRLQMQLHLRGLQNSTNDLRSQLQQLRKLQLQNLESLRALLKGTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPSNLLSQSPKKMTAETDFNKSLDFEMPPPSPPLNLHELSGPTEGAPPAPKAGNPTKGLDTPGKRSMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKTPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRTVSEVARPASTPPIMASAIKDEDDEDRIIAELEVFERSSVSPLPPTPRRQPIPTLLSPPDLGPPRASAPGPTWKVTGCPHLSQRSLCLCLHASSPHFSR", "length": 1225, "header": "tr|F1N6S8-1|F1N6S8_BOVIN Isoform 1 of SRC kinase signaling inhibitor 1 OS=Bos taurus OX=9913 GN=SRCIN1 PE=4 SV=4 CANONICAL=F1N6S8-1" }, "locus": { "chromosome": "19", "start_pos": 39219680, "end_pos": 39162370, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017913.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017913.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017913.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017913.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1030, "start_aa": "Thr", "end_pos": 1030, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1030", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1198, "start_aa": "Thr", "end_pos": 1198, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1198", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 55, "start_aa": "Thr", "end_pos": 55, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr55", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 678, "start_aa": "Thr", "end_pos": 678, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr678", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 706, "start_aa": "Thr", "end_pos": 706, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr706", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 947, "start_aa": "Thr", "end_pos": 947, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr947", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "substrate adhesion-dependent cell spreading", "id": "GO:0034446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034446", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" }, { "name": "postsynaptic actin cytoskeleton organization", "id": "GO:0098974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098974", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" }, { "name": "regulation of dendritic spine morphogenesis", "id": "GO:0061001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061001", "evidence": [ { "database": "UniProtKB", "id": "F1N6S8", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" }, { "start_pos": 924, "end_pos": 926, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6S8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1225, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6S8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6S8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6S8" }, { "id": "PF03915", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Actin interacting protein 3-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 258, "end_pos": 332, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 55, 678, 706, 947, 1030, 1198 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 370, "end_pos": 372 }, { "start_pos": 728, "end_pos": 730 }, { "start_pos": 924, "end_pos": 926 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2K8-1", "uniprot_ac": "F1N2K8", "uniprot_id": "F1N2K8_BOVIN", "mass": { "chemical_mass": 214690.0, "monoisotopic_mass": 214690.0 }, "refseq": { "ac": "XP_005224719", "name": "periplakin isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224719" }, "gene_names": [ { "name": "PPL", "type": "recommended", "evidence": [ { "id": "F1N2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ] }, { "name": "PPL", "type": "synonym", "evidence": [ { "id": "XP_005224719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224719" } ] } ], "protein_names": [ { "name": "Periplakin", "type": "recommended", "evidence": [ { "id": "F1N2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K8/entry#names_and_taxonomy" } ] }, { "name": "periplakin isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005224719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224719" } ] } ], "function": [ { "annotation": "Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8#function" }, { "database": "UniProtKB", "id": "ARBA00059924", "url": "https://www.uniprot.org/uniprotkb/ARBA00059924#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPL", "url": "https://www.uniprot.org/uniprotkb/F1N2K8", "locus": { "chromosome": "25", "start_pos": 3947863, "end_pos": 3996586, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002178", "url": "https://www.ensembl.org/id/ENSBTAG00000002178" } ] } } ], "crossref": [ { "id": "ENSBTAG00000002178", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002178", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00176", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00176", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522886", "url": "https://www.ncbi.nlm.nih.gov/gene/522886", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVG3", "url": "https://www.orthodb.org/?gene=A0A3Q1LVG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2K8", "url": "https://www.orthodb.org/?gene=F1N2K8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23169:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23169:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26346", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26346", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27015", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27015", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8851680", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8851680", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005224719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2K8-1", "url": "https://www.uniprot.org/uniprotkb/F1N2K8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRVLPGPRVPTQIPGRAPSSLQPGRGRAWKPRPPGAPPPGRYAPPSRERRGEPGPAGAPPPTSSDRPPPPRRTRGSRVAARSPAPAALPSVRAGASAAQCPARRSDPPPRPAATMNSLFRKRNKGKYSPTVRTRSVSNKELSELIEQLQKNADQVERNIVDTEAKMQRDLARLQEGQQPEHRDVALQKVSDSEKLLYMLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYNLVVKEVDPQVNWEALVEEKLDELSSQGFGTELPLVGQQVEQHNVFHNEVKAIGPHLAKEQNGELQAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAQGRIQYDWSDRNLNYPSRRRQYENFIHRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELLRKVDSDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYQHVVRGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGDQGLISRGYSYTLQRNNGESWDLTDSAGNKLTAPAVCFMIPPTDPEALALAESLGSQYQSLRQKAAGSRKALQEQHEVLKAESSGADASDLQGRQLLAGLDKVASDLDRQEKAITAILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKARSTAEGEAFVRALPDSGSTALLRTRVEDTQRRYERLVQLLEAAQEKLDIANRLEKSLQQGREMLATYETQLAQEDTVPESGQALDSRRQELAAMASELQARKALLGEVQRNLQAAKQCSGSLASRFQEHCPDLERQEAEVHKLCQRFDGLCQQAELRVQSLQSARAEHDAFCSGRDRLLQFLSHIPSYEPQETDGLGQVETKLNNQKNLLDEIARREEEVQKVHTHSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVREEEAALAAKFTEVNAINRQRLQNLEFALTLLRQQLEAGASQEALPGSKPGPGAEETWKIQEELDEEMERRQQLEHEVRSAQEEIRALRSQSPQEAVVTREVLRKVPDPALEESFQQAQQTLAEEQHKNRLLQGEVEALRLRLRALEEAARAGGQEYVVKEVLRIEPDRAQADEVLRLRGELEVLRRQKGAREAEALLLQQRVAALAEEKRRAREVVTEKEVVKVHNDPQLEAEFRQLQEDQQREQGLREKQEEELGFLQDKLKRLEKERAMAEGKITVKEVLKVEKDVAAEREVGALQRRYEDEAARARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLKSYQSELEALRRRGPQVEVKEVTKEVIKYTTDPETEKELQRLREEIVDKTRLIERCDLEIYQLKQEIQSLKEAKPQVQTKEVVQEILQFQEDPQTKEEVAALRARLAEEHKKQVDLERECVSQEEKIQEKEEELARGKEVVVQQEVVRYEEEPGLRAEVSAFTESIDAELRQIDGLRGELRRLQRRRAELEHQLEELERERQARREAELEVQHLKQQLAQLEAQEGEAHEKVTLTQKVVLQQDPQQAREHALLALQLEEERHRRQGLERELETLKQQLEHLEKMEVKEKVVFSESVQVEKGDTEQEIERLRGSLEAESRGKRELDAEVSRLEAKLSELEFCNSKSSKELDFLREENHKLQLERQSLQLEARRLQSEIEMAKAEAQSLRSLPTTTGADPGAQLDSRLRSLERELDDLRRLSRDKDQEIEELQRRLGSVAIKREQRENHLRRSIVVIDPDSGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPGGESSVIHDRKSGRKFSIEEALQSGRLTPAQYDRYVNKSMSIQELAVLVSGQK", "length": 1871, "header": "tr|F1N2K8-1|F1N2K8_BOVIN Isoform 1 of Periplakin OS=Bos taurus OX=9913 GN=PPL PE=1 SV=3 CANONICAL=F1N2K8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG3/entry", "sequence": { "sequence": "MNSLFRKRNKGKYSPTVRTRSVSNKELSELIEQLQKNADQVERNIVDTEAKMQRDLARLQEGQQPEHRDVALQKVSDSEKLLYMLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYNLVVKEVDPQVNWEALVEEKLDELSSQGFGTELPLVGQQVEQHNVFHNEVKAIGPHLAKEQNGELQAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAQGRIQYDWSDRNLNYPSRRRQYENFIHRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELLRKVDSDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYQHVVRGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGDQGLISRGYSYTLQRNNGESWDLTDSAGNKLTAPAVCFMIPPTDPEALALAESLGSQYQSLRQKAAGSRKALQEQHEVLKAESSGADASDLQGRQLLAGLDKVASDLDRQEKAITAILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKARSTAEGEAFVRALPDSGSTALLRTRVEDTQRRYERLVQLLEAAQEKLDIANRLEKSLQQGREMLATYETQLAQEDTVPESGQALDSRRQELAVSVRTPGPGSPLLSWAWALRAPVCSPPLDNRGTQGPGQQVSPGLESQPHKGFVRPAEIRVQSLQSARAEHDAFCSGRDRLLQFLSHIPSYEPQETDGLGQVETKLNNQKNLLDEIARREEEVQKVHTHSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVREEEAALAAKFTEVNAINRQRLQNLEFALTLLRQLEAGASQEALPGSKPGPGAEETWKIQEELDEEMERRQQLEHEVRSAQEEIRALRSQSPQEAVVTREVLRKVPDPALEESFQQAQQTLAEEQHKNRLLQGEVEALRLRLRALEEAARAGGQEYVVKEVLRIEPDRAQADEVLRLRGELEVLRRQKGAREAEALLLQQRVAALAEEKRRAREVVTEKEVVKVHNDPQLEAEFRQLQEDQQREQGLREKQEEELGFLQDKLKRLEKERAMAEGKITVKEVLKVEKDVAAEREVGALQRRYEDEAARARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLKSYQSELEALRRRGPQVEVKEVTKEVIKYTTDPETEKELQRLREEIVDKTRLIERCDLEIYQLKQEIQSLKEAKPQVQTKEVVQEILQFQEDPQTKEEVAALRARLAEEHKKQVDLERECVSQEEKIQEKEEELARGKEVVVQQEVVRYEEEPGLRAEVSAFTESIDAELRQIDGLRGELRRLQRRRAELEHQLEELERERQARREAELEVQHLKQQLAQLEAQEGEAHEKVTLTQKVVLQQDPQQAREHALLALQLEEERHRRQGLERELETLKQQLEHLEKMEVKEKVVFSESVQVEKGDTEQEIERLRGSLEAESRGKRELDAEVSRLEAKLSELEFCNSKSSKELDFLREENHKLQLERQSLQLEARRLQSEIEMAKAEAQSLRSLPTTTGADPGAQLDSRLRSLERELDDLRRLSRDKDQEIEELQRRLGSVAIKREQRENHLRRSIVVIDPDSGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPGGESSVIHDRKSGRKFSIEEALQSGRLTPAQYDRYVNKSMSIQELAVLVSGQK", "length": 1749, "header": "tr|A0A3Q1LVG3-1|F1N2K8_BOVIN Computationally mapped isoform of Periplakin OS=Bos taurus OX=9913 GN=PPL PE=1 SV=3 CANONICAL=F1N2K8-1" }, "locus": { "chromosome": "25", "start_pos": 3996222, "end_pos": 3948867, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068455.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068455.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059293.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059293.3" } ] } }, { "isoform_ac": "F1N2K8-1", "url": "https://www.uniprot.org/uniprotkb/F1N2K8/entry", "sequence": { "sequence": "MGRVLPGPRVPTQIPGRAPSSLQPGRGRAWKPRPPGAPPPGRYAPPSRERRGEPGPAGAPPPTSSDRPPPPRRTRGSRVAARSPAPAALPSVRAGASAAQCPARRSDPPPRPAATMNSLFRKRNKGKYSPTVRTRSVSNKELSELIEQLQKNADQVERNIVDTEAKMQRDLARLQEGQQPEHRDVALQKVSDSEKLLYMLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYNLVVKEVDPQVNWEALVEEKLDELSSQGFGTELPLVGQQVEQHNVFHNEVKAIGPHLAKEQNGELQAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAQGRIQYDWSDRNLNYPSRRRQYENFIHRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELLRKVDSDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYQHVVRGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGDQGLISRGYSYTLQRNNGESWDLTDSAGNKLTAPAVCFMIPPTDPEALALAESLGSQYQSLRQKAAGSRKALQEQHEVLKAESSGADASDLQGRQLLAGLDKVASDLDRQEKAITAILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKARSTAEGEAFVRALPDSGSTALLRTRVEDTQRRYERLVQLLEAAQEKLDIANRLEKSLQQGREMLATYETQLAQEDTVPESGQALDSRRQELAAMASELQARKALLGEVQRNLQAAKQCSGSLASRFQEHCPDLERQEAEVHKLCQRFDGLCQQAELRVQSLQSARAEHDAFCSGRDRLLQFLSHIPSYEPQETDGLGQVETKLNNQKNLLDEIARREEEVQKVHTHSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVREEEAALAAKFTEVNAINRQRLQNLEFALTLLRQQLEAGASQEALPGSKPGPGAEETWKIQEELDEEMERRQQLEHEVRSAQEEIRALRSQSPQEAVVTREVLRKVPDPALEESFQQAQQTLAEEQHKNRLLQGEVEALRLRLRALEEAARAGGQEYVVKEVLRIEPDRAQADEVLRLRGELEVLRRQKGAREAEALLLQQRVAALAEEKRRAREVVTEKEVVKVHNDPQLEAEFRQLQEDQQREQGLREKQEEELGFLQDKLKRLEKERAMAEGKITVKEVLKVEKDVAAEREVGALQRRYEDEAARARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLKSYQSELEALRRRGPQVEVKEVTKEVIKYTTDPETEKELQRLREEIVDKTRLIERCDLEIYQLKQEIQSLKEAKPQVQTKEVVQEILQFQEDPQTKEEVAALRARLAEEHKKQVDLERECVSQEEKIQEKEEELARGKEVVVQQEVVRYEEEPGLRAEVSAFTESIDAELRQIDGLRGELRRLQRRRAELEHQLEELERERQARREAELEVQHLKQQLAQLEAQEGEAHEKVTLTQKVVLQQDPQQAREHALLALQLEEERHRRQGLERELETLKQQLEHLEKMEVKEKVVFSESVQVEKGDTEQEIERLRGSLEAESRGKRELDAEVSRLEAKLSELEFCNSKSSKELDFLREENHKLQLERQSLQLEARRLQSEIEMAKAEAQSLRSLPTTTGADPGAQLDSRLRSLERELDDLRRLSRDKDQEIEELQRRLGSVAIKREQRENHLRRSIVVIDPDSGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPGGESSVIHDRKSGRKFSIEEALQSGRLTPAQYDRYVNKSMSIQELAVLVSGQK", "length": 1871, "header": "tr|F1N2K8-1|F1N2K8_BOVIN Isoform 1 of Periplakin OS=Bos taurus OX=9913 GN=PPL PE=1 SV=3 CANONICAL=F1N2K8-1" }, "locus": { "chromosome": "25", "start_pos": 3996567, "end_pos": 3948867, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002822.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002822.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002822.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002822.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 566, "start_aa": "Thr", "end_pos": 566, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr566", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 63, "start_aa": "Thr", "end_pos": 63, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr63", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" }, { "id": "R-BTA-8851680", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8851680", "resource": "Reactome", "description": "Butyrophilin (BTN) family interactions" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "cornified envelope", "id": "GO:0001533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001533", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intermediate filament cytoskeleton organization", "id": "GO:0045104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045104", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "response to mechanical stimulus", "id": "GO:0009612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009612", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" }, { "name": "wound healing", "id": "GO:0042060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "F1N2K8", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1855, "end_pos": 1857, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" }, { "id": "PF17902", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17902" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Desmoplakin SH3", "eco_id": "ECO_0000259", "start_pos": 501, "end_pos": 564, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" }, { "id": "PF26346", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26346" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Periplakin-like plectin repeat", "eco_id": "ECO_0000259", "start_pos": 1118, "end_pos": 1280, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K8" }, { "id": "PF23160", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23160" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Periplakin/Envoplakin N-terminal", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 241, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 63, 566 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1855, "end_pos": 1857 }, { "start_pos": 663, "end_pos": 665 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4N6-1", "uniprot_ac": "F1N4N6", "uniprot_id": "F1N4N6_BOVIN", "mass": { "chemical_mass": 132660.0, "monoisotopic_mass": 132660.0 }, "refseq": { "ac": "XP_024847312", "name": "SWI/SNF complex subunit SMARCC2 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847312" }, "gene_names": [ { "name": "SMARCC2", "type": "recommended", "evidence": [ { "id": "F1N4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ] }, { "name": "SMARCC2", "type": "synonym", "evidence": [ { "id": "XP_024847312", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847312" } ] } ], "protein_names": [ { "name": "SWI/SNF complex subunit SMARCC2 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024847312", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847312" } ] }, { "name": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2", "type": "synonym", "evidence": [ { "id": "F1N4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMARCC2", "url": "https://www.uniprot.org/uniprotkb/F1N4N6", "locus": { "chromosome": "5", "start_pos": 57161786, "end_pos": 57141033, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014697", "url": "https://www.ensembl.org/id/ENSBTAG00000014697" } ] } } ], "crossref": [ { "id": "F1N4N6", "url": "https://alphafold.ebi.ac.uk/entry/F1N4N6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014697", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014697", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509060", "url": "https://www.ncbi.nlm.nih.gov/gene/509060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509060", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR15381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15381:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15381:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00249", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00249", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04433", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04433", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16495", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16495", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16498", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16498", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024847312", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847312", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVW2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4N6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4N6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNSASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVNDDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETTGKDEDESSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQQNSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGTDEARAEGQATEDKKEPKEPREGVGTVEEEAKEKTSEAPKKDDEKGKDGDSEKESEKSDGDPTADPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQQQQQPPPALPPGSQPIPPPGAAGPPTVHGLAMAPASVAPAPAGSGAPPGSLGPSEQLGQAGSTVGPQQQPPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPPPPPAPSIIPFGSLADSISINLPPPPNLHGHHHHLPFAPATLPPPNLPVSMANPLHPNLPATTTMPSSLPLGPGLGSAAAQSPAIVAAVQGNLLPSASPLPDPGTPLPPDPTAPSPGTVTPVPPPQ", "length": 1212, "header": "tr|F1N4N6-1|F1N4N6_BOVIN Isoform 1 of SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 OS=Bos taurus OX=9913 GN=SMARCC2 PE=3 SV=4 CANONICAL=F1N4N6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW2/entry", "sequence": { "sequence": "MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNSASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVNDDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETTGKDEDESSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQGRQVDADTKAGRKGKELDDLVPETAKGKPELQNSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGTDEARAEGQATEDKKEPKEPREGVGTVEEEAKEKTSEAPKKDDEKGKDGDSEKESEKSDGDPTADPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQQQQQPPPALPPGSQPIPPPGAAGPPTVHGLAMAPASVAPAPAGSGAPPGSLGPSEQLGQAGSTVGPQQQPPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPSMMPGAVPGSGHPGVADPGTPLPPDPTAPSPGTVTPVPPPQ", "length": 1130, "header": "tr|A0A3Q1LVW2-1|F1N4N6_BOVIN Computationally mapped isoform of SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 OS=Bos taurus OX=9913 GN=SMARCC2 PE=3 SV=1 CANONICAL=F1N4N6-1" }, "locus": { "chromosome": "5", "start_pos": 57159878, "end_pos": 57141059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073340.1", "url": "https://www.ensembl.org/id/ENSBTAT00000073340.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061567.1" } ] } }, { "isoform_ac": "F1N4N6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4N6/entry", "sequence": { "sequence": "MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNSASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVNDDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETTGKDEDESSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQQNSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGTDEARAEGQATEDKKEPKEPREGVGTVEEEAKEKTSEAPKKDDEKGKDGDSEKESEKSDGDPTADPEKEKEPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQQQQQPPPALPPGSQPIPPPGAAGPPTVHGLAMAPASVAPAPAGSGAPPGSLGPSEQLGQAGSTVGPQQQPPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPPPPPAPSIIPFGSLADSISINLPPPPNLHGHHHHLPFAPATLPPPNLPVSMANPLHPNLPATTTMPSSLPLGPGLGSAAAQSPAIVAAVQGNLLPSASPLPDPGTPLPPDPTAPSPGTVTPVPPPQ", "length": 1212, "header": "tr|F1N4N6-1|F1N4N6_BOVIN Isoform 1 of SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 OS=Bos taurus OX=9913 GN=SMARCC2 PE=3 SV=4 CANONICAL=F1N4N6-1" }, "locus": { "chromosome": "5", "start_pos": 57159878, "end_pos": 57141059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019562.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019562.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019562.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019562.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1198, "start_aa": "Thr", "end_pos": 1198, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1198", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 230, "start_aa": "Thr", "end_pos": 230, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr230", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 308, "start_aa": "Thr", "end_pos": 308, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr308", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509060", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear lumen", "id": "GO:0031981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031981", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" }, { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" }, { "name": "npBAF complex", "id": "GO:0071564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071564", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" }, { "name": "nBAF complex", "id": "GO:0071565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071565", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1N4N6", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 857, "end_pos": 859, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4N6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1212, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4N6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4N6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" }, { "id": "PS52032", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52032" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chromo", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 274, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" }, { "id": "PS50090", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50090" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myb-like", "eco_id": "ECO_0000259", "start_pos": 601, "end_pos": 643, "start_aa": "Trp", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" }, { "id": "PS51293", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51293" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SANT", "eco_id": "ECO_0000259", "start_pos": 596, "end_pos": 647, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N6" }, { "id": "PS50934", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50934" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SWIRM", "eco_id": "ECO_0000259", "start_pos": 424, "end_pos": 521, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 230, 308, 1198 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 416, "end_pos": 418 }, { "start_pos": 454, "end_pos": 456 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 857, "end_pos": 859 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N294-1", "uniprot_ac": "F1N294", "uniprot_id": "F1N294_BOVIN", "mass": { "chemical_mass": 56303.0, "monoisotopic_mass": 56303.0 }, "refseq": { "ac": "XP_002698883", "name": "monocarboxylate transporter 9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698883" }, "gene_names": [ { "name": "SLC16A9", "type": "recommended", "evidence": [ { "id": "F1N294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ] }, { "name": "SLC16A9", "type": "synonym", "evidence": [ { "id": "XP_002698883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698883" } ] } ], "protein_names": [ { "name": "Monocarboxylate transporter 9", "type": "recommended", "evidence": [ { "id": "F1N294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N294/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 16 member 9", "type": "synonym", "evidence": [ { "id": "F1N294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N294/entry#names_and_taxonomy" } ] }, { "name": "monocarboxylate transporter 9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698883", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698883" } ] } ], "function": [ { "annotation": "Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN3#function" }, { "database": "UniProtKB", "id": "ARBA00058966", "url": "https://www.uniprot.org/uniprotkb/ARBA00058966#function" }, { "database": "UniProtKB", "id": "A0A3Q1MIA6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIA6#function" }, { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC16A9", "url": "https://www.uniprot.org/uniprotkb/F1N294", "locus": { "chromosome": "28", "start_pos": 15308710, "end_pos": 15393234, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019792", "url": "https://www.ensembl.org/id/ENSBTAG00000019792" } ] } } ], "crossref": [ { "id": "F1N294", "url": "https://alphafold.ebi.ac.uk/entry/F1N294", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019792", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019792", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17428", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17428", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539514", "url": "https://www.ncbi.nlm.nih.gov/gene/539514", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539514", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539514", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WLHTYQE", "url": "https://omabrowser.org/oma/group/WLHTYQE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXN3", "url": "https://www.orthodb.org/?gene=A0A3Q1LXN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIA6", "url": "https://www.orthodb.org/?gene=A0A3Q1MIA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N294", "url": "https://www.orthodb.org/?gene=F1N294", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11360", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11360:SF158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698883", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIA6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N294-1", "url": "https://www.uniprot.org/uniprotkb/F1N294-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFKKPPDGGWGWVIVVVSFFTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWIGSLASGVGLLASPVCSVCVSSFGARAVTIFSGFLVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRLLIEFYGLDGCLLIVGALALNILACGSLMRPLQSSDFPLPEKTALENVPDRYSIYKEKEKDPEENINMLEKSYIGEETCKSTLANGDWKSESLLHKNPTTMSRTKETETYKKKVAERTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAIFLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLILGILADFKWINTLYLYVATLIIMSLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGLCVLLGGFILLLAALPSWDTCKKQLPKPAPTTFLYKVASNSSNV", "length": 513, "header": "tr|F1N294-1|F1N294_BOVIN Isoform 1 of Monocarboxylate transporter 9 OS=Bos taurus OX=9913 GN=SLC16A9 PE=3 SV=2 CANONICAL=F1N294-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN3/entry", "sequence": { "sequence": "MEFKKPPDGGWGWVIVVVSFFTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWIGSLASGVGLLASPVCSVCVSSFGARAVTIFSGFLVAGGLMLSSFAPNIYFLFFSYGIVVGSSVGLFIYAALQRLLIEFYGLDGCLLIVGALALNILACGSLMRPLQSSDFPLPEKTALENVPDRYSIYKEKEKDPEENINMLEKSYIGEETCKSTLANGDWKSESLLHKNPTTMSRTKETETYKKKVAERTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAIFLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLILGILADFKWINTLYLYVATLIIMSLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGLCVLLGGFILLLAALPSWDTCKKQLPKPAPTTFLYKVASNSSNV", "length": 481, "header": "tr|A0A3Q1LXN3-1|F1N294_BOVIN Computationally mapped isoform of Monocarboxylate transporter 9 OS=Bos taurus OX=9913 GN=SLC16A9 PE=3 SV=1 CANONICAL=F1N294-1" }, "locus": { "chromosome": "28", "start_pos": 15355953, "end_pos": 15309714, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079636.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079636.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061972.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061972.1" } ] } }, { "isoform_ac": "A0A3Q1MIA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIA6/entry", "sequence": { "sequence": "MEFKKPPDGGWGWVIVVVSFFTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWIGSLASGVGLLASLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRLLIEFYGLDGCLLIVGALALNILACGSLMRPLQSSDFPLPEKTALENVPDRYSIYKEKEKDPEENINMLEKSYIGEETCKSTLANGDWKSESLLHKNPTTMSRTKETETYKKKVAERTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAIFLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLILGILADFKWINTLYLYVATLIIMSLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGLCVLLGGFILLLAALPSWDTCKKQLPKPAPTTFLYKVASNSSNV", "length": 465, "header": "tr|A0A3Q1MIA6-1|F1N294_BOVIN Computationally mapped isoform of Monocarboxylate transporter 9 OS=Bos taurus OX=9913 GN=SLC16A9 PE=3 SV=1 CANONICAL=F1N294-1" }, "locus": { "chromosome": "28", "start_pos": 15355953, "end_pos": 15309714, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086385.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086385.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070443.1" } ] } }, { "isoform_ac": "F1N294-1", "url": "https://www.uniprot.org/uniprotkb/F1N294/entry", "sequence": { "sequence": "MEFKKPPDGGWGWVIVVVSFFTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWIGSLASGVGLLASPVCSVCVSSFGARAVTIFSGFLVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRLLIEFYGLDGCLLIVGALALNILACGSLMRPLQSSDFPLPEKTALENVPDRYSIYKEKEKDPEENINMLEKSYIGEETCKSTLANGDWKSESLLHKNPTTMSRTKETETYKKKVAERTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAIFLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLILGILADFKWINTLYLYVATLIIMSLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGLCVLLGGFILLLAALPSWDTCKKQLPKPAPTTFLYKVASNSSNV", "length": 513, "header": "tr|F1N294-1|F1N294_BOVIN Isoform 1 of Monocarboxylate transporter 9 OS=Bos taurus OX=9913 GN=SLC16A9 PE=3 SV=2 CANONICAL=F1N294-1" }, "locus": { "chromosome": "28", "start_pos": 15355953, "end_pos": 15309714, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026369.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026369.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026369.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026369.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539514", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539514", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BA41-1", "protein_name": "Monocarboxylate transporter 9", "gene_name": "SLC16A9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEYKKSPDGGWGWVIVFVSFCTQFLCYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARAVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRLLIDLYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPEKTALENIPDRYSIYNEKEKNLEENINILEKSYSGEETCKSTLANGDWKSDSLLHQNPTTAAQTKETETYKKKVAERTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAIFLFDIGGFPPSLLMEDVARSSNVKEEEFLMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMSLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGLILLLAALPSCDTCKKQLPKPAPTTFLYKVASNSSNV", "length": 513 }, "evidence": [ { "id": "F1N294", "url": "https://omabrowser.org/oma/group/F1N294/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9P097-1", "protein_name": "Monocarboxylate transporter 9", "gene_name": "slc16a9a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAVKSESTLDGGWGWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALALNLMACAGPMRPLNLPGYYLKQRAALQRTEDPEPLYSKPTAIIIESGSDLKTKPGLAENTTTVKLLINKDPTELQDSEGERKVHILSSSIIARAIKKWMRPYGQYFCETVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLAALPCWNRTAQEGNSQAEEDVNTSQQHHSFDCDKVASVA", "length": 512 }, "evidence": [ { "id": "F1N294", "url": "https://omabrowser.org/oma/group/F1N294/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Y7B5-1", "protein_name": "Monocarboxylate transporter 9", "gene_name": "SLC16A9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVYRKPPDGGWGWVIVIVSFFTQFLCYGSPLAVGVLYLEWLDAFGEGKGKTAWVGSLANGIGLLASPVCSICVSSFGARPVAIFSGFMVAGGLMMSSFAPNIYFLYLSYGIVVGLGCGLLYNATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLIVGALSLNILACGSLMRPLESSDSPSPEKACTDKVPDQYFVYHEKEKTVEENISILEKGYIDEKCANNVPDYKQDNILNKNVLSSINVNEKDTYKKKVVEQTNFCKQLAKRKWQLYLNYWEETVVLFKNRVFSALFFAILLFDIGGFPPSLLMEDIARSANINEEDYHMPLVSIIGIMTAIGKLILGILADFKWVNTLYLYVLTLLMMGAALLAIPFARSYFTLAVLSGILGFLTGNWSIFPYVTTKTVGIEKLTHAYGILMFFAGLGNSLGPPIVGWFYDWTQEYDTAFYFSGFCVLLGGFLLLLAALPCWNACTDRSSKLPPNTYSYKVASSA", "length": 507 }, "evidence": [ { "id": "F1N294", "url": "https://omabrowser.org/oma/group/F1N294/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "M0RCI4-1", "protein_name": "Monocarboxylate transporter 9", "gene_name": "Slc16a9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFQKSPDGGWGWVIVVVSFFTQFLCYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKIAPENVPDRYSIYNEKEKNQEETMTFQDKGYSNEDKCLPNGDWGRETSLPKNPTGAAHTKEPEPYKKKVVEQTNFCKQLAKRKWQVYRNYCGETASLFKNKVFSALFVAILLFDIGGFPPSLLMEDVARSYHVREEDLTIPLISIFGIMTAVGKLLLGILADFKWVNTLYLYVATLIITGLALCAIPLAKSYVTLAILSGILGFLTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAILPCWGMCNQRLPKPAAPTTFFYKVASNV", "length": 508 }, "evidence": [ { "id": "F1N294", "url": "https://omabrowser.org/oma/group/F1N294/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7RTY1-1", "protein_name": "Monocarboxylate transporter 9", "gene_name": "SLC16A9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELKKSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKGKNLEENINILDKSYSSEEKCRITLANGDWKQDSLLHKNPTVTHTKEPETYKKKVAEQTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFLYKVASNV", "length": 509 }, "evidence": [ { "id": "F1N294", "url": "https://omabrowser.org/oma/group/F1N294/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TM99-1", "protein_name": "Monocarboxylate transporter 9", "gene_name": "Slc16a9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEFQKSPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKTAPENVPDRYSMYNEKEKNPEETMNFQDKGYSSEDKCLPNGDWGRETSLPKSLAIAAHTKEPETYKKKVVEQTNFCKQLAKRKWQLYRNYCGETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAILPCWDMCNKKLPKPAVPTTFFYKVASNV", "length": 508 }, "evidence": [ { "id": "F1N294", "url": "https://omabrowser.org/oma/group/F1N294/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" }, { "name": "monocarboxylic acid transmembrane transporter activity", "id": "GO:0008028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008028", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" }, { "name": "creatine transmembrane transporter activity", "id": "GO:0005308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005308", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" }, { "name": "carnitine transmembrane transporter activity", "id": "GO:0015226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015226", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "urate metabolic process", "id": "GO:0046415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046415", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" }, { "name": "carboxylic acid transmembrane transport", "id": "GO:1905039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905039", "evidence": [ { "database": "UniProtKB", "id": "F1N294", "url": "https://www.uniprot.org/uniprotkb/F1N294" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N294-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 513, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N294-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N294" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N294" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 487, "start_aa": "Ile", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 412, "end_pos": 414 }, { "start_pos": 509, "end_pos": 511 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1C8-1", "uniprot_ac": "F1N1C8", "uniprot_id": "F1N1C8_BOVIN", "mass": { "chemical_mass": 86975.0, "monoisotopic_mass": 86975.0 }, "refseq": { "ac": "XP_024840741", "name": "BRCA1-associated ATM activator 1 isoform X6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741" }, "gene_names": [ { "name": "BRAT1", "type": "recommended", "evidence": [ { "id": "F1N1C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C8" } ] }, { "name": "BAAT1", "type": "synonym", "evidence": [ { "id": "XP_024840741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741" } ] }, { "name": "BRAT1", "type": "synonym", "evidence": [ { "id": "XP_024840741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741" } ] }, { "name": "C25H7orf27", "type": "synonym", "evidence": [ { "id": "XP_024840741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741" } ] }, { "name": "C7orf27", "type": "synonym", "evidence": [ { "id": "XP_024840741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741" } ] } ], "protein_names": [ { "name": "BRCA1 associated ATM activator 1", "type": "synonym", "evidence": [ { "id": "F1N1C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C8/entry#names_and_taxonomy" } ] }, { "name": "BRCA1-associated ATM activator 1 isoform X6", "type": "synonym", "evidence": [ { "id": "XP_024840741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1C8", "url": "https://www.uniprot.org/uniprotkb/F1N1C8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRAT1", "url": "https://www.uniprot.org/uniprotkb/F1N1C8", "locus": { "chromosome": "25", "start_pos": 40660262, "end_pos": 40670945, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014502", "url": "https://www.ensembl.org/id/ENSBTAG00000014502" } ] } } ], "crossref": [ { "id": "F1N1C8", "url": "https://alphafold.ebi.ac.uk/entry/F1N1C8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014502", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014502", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532550", "url": "https://www.ncbi.nlm.nih.gov/gene/532550", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IQVFTEW", "url": "https://omabrowser.org/oma/group/IQVFTEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1C8", "url": "https://www.orthodb.org/?gene=F1N1C8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21331", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21331", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21331:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21331:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840741", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840741", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXW2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C8", "url": "https://www.uniprot.org/uniprotkb/F1N1C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPECARLLPALCDVLADPRQPVADDTCLEKLLDWFKAVTEAGSSLLLLQDHPCLVELLFHVLKPQDLSSRILSFVLRLAGIFAAQENCFQYLQQGELLPGLFGEPGPLGAAAWAAPSVRSGWIQGLHSLAQHPSALRFLADSGAVDTIFSLQGDPSLFVASAAGQLLVRVLDLALCGPAEGHISLQAWDWPACARKIVCHLEDCLRSEATPRVTQALHVLTTAFGHCHGLWTQGLWVQLSPLVARLLEKDPVPAPHALVDLLLSVARSSMLSSDPGLWETAAQTLSRLSPTQAGPLAAGILKLQDCPQALRIQAFGVLLQPLAFVLEATAQAPGMPGLLEGAAGDLMAVDTLPPSKSACVGLLCSALAHLELLQPLPQRPSPWPQAPLLAAVVAILRLCNGSAAPNSEAGGRLCAMLGGCVRVQRAALDFLGVLSQGLGPQELVTQVFAILLEYLVSPDSSPTVLKKAFQATLCWLLSSAAPPGCCDLEPYAQLVLGELLSVLRKRLCSPCWEVRDSGLEFLTQMTRHQGGQAGFRQALLASEVPELTRQLLQDPESYVRASAVAAVGQLSSWGLLAAPSSPEHAATPQKTPLEELLLVLTTDSEGFPRRAVMRVFTEWLRDGYADVAEDPERFVARVLQAASGDLDWEVRVQGLELALAFLEQLLGPCGPSAVAPPGALAQALQALCRVQLFEFAFRSLFDCDRPVAQKSCDLLLFLRAKAIPSSNSQEAGDGPDVTSVEAALRRWQAGEQGQPLGELAPEAVLAVLRSMDLEALQDTLAESSDHVERSPQSLLQDMLATVGVLGDNEADCY", "length": 814, "header": "tr|F1N1C8-1|F1N1C8_BOVIN Isoform 1 of BRCA1 associated ATM activator 1 OS=Bos taurus OX=9913 GN=BRAT1 PE=3 SV=3 CANONICAL=F1N1C8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXW2/entry", "sequence": { "sequence": "MDPECARLLPALCDVLADPRQPVADDTCLEKLLDWFKAVTEAGSSLLLLQDHPCLVELLFHVLKPQDLSSRILSFVLRLAGIFAAQENCFQYLQGDPSLFVASAAGQLLVRVLDLALCGPAEGHISLQAWDWPACARKIVCHLEDCLRSEATPRVTQALHVLTTAFGHCHGLWTQGLWVQLSPLVARLLEKDPVPAPHALVDLLLSVARSSMLSSDPGLWETAAQTLSRLSPTQAGPLAAGILKLQDCPQALRIQAFGVLLQPLAFVLEATAQAPGMPGLLEGAAGDLMAVDTLPPSKSACVGLLCSALAHLELLQPLPQRPSPWPQAPLLAAVVAILRLCNGSAAPNSEAGGRLCAMLGGCVRVQRAALDFLGVLSQGLGPQELVTQVFAILLEYLVSPDSSPTVLKKAFQATLCWLLSSAAPPGCCDLEPYAQLVLGELLSVLRKRLCSPCWEVRDSGLEFLTQMTRHQGGQAGFRQALLASEVPELTRQLLQDPESYVRASAVAAVGQLSSWGLLAAPSSPEHAATPQKTPLEELLLVLTTDSEGFPRRAVMRVFTEWLRDGYADVAEDPERFVARVLQAASGDLDWEVRVQGLELALAFLEQLLGPCGPSAVAPPGALAQALQALCRVQLFEFAFRSLFDCDRPVAQKSCDLLLFLRAKAIPSSNSQEAGDGPDVTSVEAALRRWQAGEQGQPLGELAPEAVLAVLRSMDLEALQDTLAESSDHVERSPQSLLQDMLATVGVLGDNEADCY", "length": 755, "header": "tr|A0A3Q1LXW2-1|F1N1C8_BOVIN Computationally mapped isoform of BRCA1 associated ATM activator 1 OS=Bos taurus OX=9913 GN=BRAT1 PE=3 SV=2 CANONICAL=F1N1C8-1" }, "locus": { "chromosome": "25", "start_pos": 40669877, "end_pos": 40661266, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086978.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086978.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062079.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062079.2" } ] } }, { "isoform_ac": "F1N1C8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C8/entry", "sequence": { "sequence": "MDPECARLLPALCDVLADPRQPVADDTCLEKLLDWFKAVTEAGSSLLLLQDHPCLVELLFHVLKPQDLSSRILSFVLRLAGIFAAQENCFQYLQQGELLPGLFGEPGPLGAAAWAAPSVRSGWIQGLHSLAQHPSALRFLADSGAVDTIFSLQGDPSLFVASAAGQLLVRVLDLALCGPAEGHISLQAWDWPACARKIVCHLEDCLRSEATPRVTQALHVLTTAFGHCHGLWTQGLWVQLSPLVARLLEKDPVPAPHALVDLLLSVARSSMLSSDPGLWETAAQTLSRLSPTQAGPLAAGILKLQDCPQALRIQAFGVLLQPLAFVLEATAQAPGMPGLLEGAAGDLMAVDTLPPSKSACVGLLCSALAHLELLQPLPQRPSPWPQAPLLAAVVAILRLCNGSAAPNSEAGGRLCAMLGGCVRVQRAALDFLGVLSQGLGPQELVTQVFAILLEYLVSPDSSPTVLKKAFQATLCWLLSSAAPPGCCDLEPYAQLVLGELLSVLRKRLCSPCWEVRDSGLEFLTQMTRHQGGQAGFRQALLASEVPELTRQLLQDPESYVRASAVAAVGQLSSWGLLAAPSSPEHAATPQKTPLEELLLVLTTDSEGFPRRAVMRVFTEWLRDGYADVAEDPERFVARVLQAASGDLDWEVRVQGLELALAFLEQLLGPCGPSAVAPPGALAQALQALCRVQLFEFAFRSLFDCDRPVAQKSCDLLLFLRAKAIPSSNSQEAGDGPDVTSVEAALRRWQAGEQGQPLGELAPEAVLAVLRSMDLEALQDTLAESSDHVERSPQSLLQDMLATVGVLGDNEADCY", "length": 814, "header": "tr|F1N1C8-1|F1N1C8_BOVIN Isoform 1 of BRCA1 associated ATM activator 1 OS=Bos taurus OX=9913 GN=BRAT1 PE=3 SV=3 CANONICAL=F1N1C8-1" }, "locus": { "chromosome": "25", "start_pos": 40669877, "end_pos": 40661266, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019280.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019280.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019280.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019280.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZBQ7-1", "protein_name": "BRCA1 associated ATM activator 1", "gene_name": "BRAT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSPRGRRAMSRACARLLPRVCAALADPRQPGSDDTCLEKMLDWFRELREAEPTVKLLRDNPCLTEFFTAVLALPEPEPNVLSFTLRLAGIVAAVEDSFMHLQQLELLARLFGEDGPLNSAAWEDASVRSGWVEGVHSMVQHQSALHFICSGGGIDVIFTLQGDPSLFVASAACRLLVHLLTLSVGSELTVPLNAKDCDWPACAHMIIRHIEESLQSNSASHIKQSLKLLTSLFGSCQAPWTKVLWLGMAKQVESFLTEDSVQAQHILADLLLNMARSPVFHDTEGSFWALVTSALEHLTPVQSSPLAVGILRLHRCPQVVRIKALTVLLQPMDCILRAAFQPLEYAGLLDESVSDPSAVESLLSSKSSCASLLCQTLAHLEELLSVVFLPVNLPYASLLRSVVTILQFCNGLLIPASPLGSKISQILVGCFRVQKSALDALAALSDRKCSDTVVGSLFDVLLAYLESPNTTPTVLKKSFKAMSKWLMSLPGMSFFKNQQQTEKTLQDVFLVLQKRLCSPCWEVRDSSLEFLTNLIRNLRDHDEFRQSLLSSEVPKLTENLLEDPESYVRASAVTAMGHLAFITYFFVPESPVAGNQYNKEKTVAKLQEILSTDPEGFPRRAVMNVFTMWLKESCTGQLEETEQFVSTVVQTTAHDLDWEVKLGCLELVQIFCNHMFCRFGLPECPYAPISSAVTSSICQNEPLQIFCRANLFSFLFRSLCDCDKPVGQKACDILLALKSHFCQSSTTDLQGPGDLSAGHGIHWLQGTLRQGSLVQNFPTDDGNGVDFQDPESMMLALRTIDLVELHNDLNKCSDYVEKSPQSLLEDILATVGTAEENEADCY", "length": 842 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZSM9-1", "protein_name": "Integrator complex assembly factor BRAT1", "gene_name": "Brat1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAECSRLLPALCAVLADPRQLVADDTCLEKLLDWFKTVTEAEPSLQLLQDHPCLMELLSHVLKPQDVSPRVLSFALRLVGVFAAQEDCFQYLQQGELLLGLFGETGALSWAAWSIPSVRSGWIQGLCSLAHHPSALHFLADSGAVDTIFSLQGDPSLFVASAASQLLVHILALSMQGGAPGSPVPEAVAWPVCAQKIMNHVEESLHSKATPQVTQALNVLTTTFGRCHNPWTGVLWERLSPPVARLFERDPIPATHSLMDLLLSVARSPVLNFAACGLWEMLAQTLSRLSPTQAGPLALGTLKLQHCPQELRTQAFRVLLQPLACILKATTQAPGPPGLLDGTAGSLLTVDALLSSKSACVGLLCQTLAHLEELQMLPQCPSPWPQVPLLQAAVTILRLSDGSADPSSSAGGRLCGALGGCVRVQRAALDFLGTLSLGTSPLELVLEVFAVLLKTLESPESSPMVLKKAFQATLRWLQSPHKTPSGSDLSPDALLFLGELFPILQKRLCSPCWEVRDSALEFLTHLIRDWGGQADFREALHSSEVPTLARQLLQDPESYVRASAVGAAGQLSSQGLQATPANQQGLLMDLMHILSTDSEGFPRRAVLRVFTEWLRDGHADVVRDTEWFVATVLQAVSRDLDWEVRVQGLELAQVFLIQAMGQPRLHCPYTVGLPGATSSRPHLEFLQTLCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTVSCSNPQEAGDSPNSASVEAALQRWREGEQAQPLGDLEPEAMLAILRSLDLEGLQGRLAKSSDHVEKSPQSLLQDMLATVGVLEENEADCY", "length": 816 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RI80-1", "protein_name": "BRCA1 associated ATM activator 1", "gene_name": "BRAT1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPECSRLLPALCAVLADPRQPVADDTCLEKLLDWFKTITEAGSSLLVLQENPCLVELLFHVLKPQDLSPRVLSFSLRLAGMFAAQEDCFQYLQQGELLPRLFGEAGPLGGAAWTAPTVRSGWIQGLRSLAQHPRALPFLADCGAVDTIFSLQGDSSLFVASAAGQLLVHILDLAMRAPPRGHPGPQACDGPACAQKIVCHLEDSLRAAAAPQLTQALNVLTTTFGHCHGLWTPGLWGRLSPLVGHLLEKDPVPASHALVDLLLSVARSPVLSSESGPWETLALTLSRLSPMQAGPLALGILKLQDCPQALRTQASGVLLQPLACVLKAAVQGPGRPGLPDGAAGDSVTVDTLFSSKSACVGLLCCALAHLELLQLLPQCPSPWPQEALLEAVVTVLRFCNGSAVPASDLGGHLCATLVGCVRVQRAALDFLGTLSQRAGPQELVTQVSAVLLEYLSGPDSSPTVLKKAFQASLGWLLSSPKTPGCCDLDPHAQQFLRELLPVLQKRLCSPCWEVRDSGLEFLTQMARHWGGQAAFRQVLLASEVPRLTRQLLQDPESYVRASAVTATGQLSSWGLHAAPAGPEQPGVQQKSLLSELLHVLATDSEGFPRRAVMQVFTEWLRGGHADVAEDPEQFVAGVLQAASRDLDWEVRAQGLELALVFLEQLLGPPGVRCPYAVALPKAAPPGTLAQALQALCRVQLFEFAFRALFDCDRPVAQKSCDLLLFLKAKATSCGTPQEERDSPDVSSVEATLQKWQAGEHGHPLGDLEPAAVVAVLRSMDLEGLQDTLAESSDHVERSPQSLLQDMLATVGVLGENEADCY", "length": 822 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GVE7-1", "protein_name": "Integrator complex assembly factor BRAT1", "gene_name": "Brat1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPECSKLLPALCAVLADPRQLVADDTCLEKLLDWFKTVMETESSLHLLQDHPCLMELLSHVLKTQDVSPRVLSFVLRLVGIFAAQEDCFQYLQQGELLLGLFGETGALSWTAWNMPSVRSGWIQGLCSLAHHPSALHFLADSGAVDTIFALQGDPSLFVASAASQLLVHILALAMQGGASGSPISEAAAWPICAQKIVNHVEESLHSKATPQVTQALNVLTTTFGRCHSPWTGVLWGRLSPPVACLFERDPIPAVHSLMDLLLSVARSHVLNFAACGLWEMLAQTLSRLSPTQAGPLALGTLKLQHCPQELRTQAFGVLLQPLACILKATTQAPGPPGLLDGTAGSSLTVDALLSSKSACVGLLCQTLAHLEELQMLPQCPCPWPQVPLLGATVTILRLCDGSVDPSSSMGGRLCGTLGGCVRVQRAALDFLGTLSQGTSPLELVLEVFAVLLKTLESPESSPTVLKKAFQATLRWLQNSHKTPNCSDLSPDALLFLGELFPILQKRLCSPCWEVRDSALEFLTHLIRHWGGQADFREALHSSEVPTLARQLLQDPESYVRASAVGTAGQLSSRGLQATSASPENPLAQQGLLMDLMHILSTDSEGFPRRAVLRVFTEWLRDGHADVIRDTEWFVATVLQAVSRDLDWEVRMQGLELAQVFLIQAMGQPSLHCPYTVGLPEATSPRPHPEFLQTLCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTTHCSGPQEAGDSPNSASVEAVLQRWREGEQGQPLGDLEPEAMLAILRSLDLEGLQGKLAKSSDHVEKSPQSLLQDMLATVGILEENEADCY", "length": 822 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1RLU1-1", "protein_name": "Integrator complex assembly factor BRAT1", "gene_name": "brat1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDGDCSSLLPAVCLVLADPKQTPPDDTSLEKLLDWFKDLHSQSNGQVLLEHQPCLLEFISSVCASKATDPAILSFTLKLTGLLAASKQDFHLLEEGGHLVCVFEREAWSVCDLWEDASVRSGWIQGLLNMLKHQQALDFICRQGLIKVILQLQNDRSLFVACLANQLLVQILKLLTPSDVTSGSDAVVSSKSSSSLDWVSVSSEITNAVVEALSSENHPQVLQGVQLLSLVLSQCEEPIRSSLWKDVLPPLEVLINRGSEPLTQPLMTVLRAAVMTPLLGQSEYKVEEFLEVMLGTGNRKEGILCATLIVKLEKCPKVLKRKAMDIILLPLQCVSTQSQDEKEVDLVLKEPLSQKALCISLLVQSLSSLAELAHKEYFEGVCIPSVTSRVVQLLRVCSGHCTSSLLHVSACTHLIGSCKIQRCGLDTLGALSVYEDNLDLRKDIFGVLLDYLKSPDSHATVLKKTFQAVLRWIGVCASFPDLLQFISNDLFPVLEKRMCDVRWEVRDSTLEFITQLTVALSDNSGFVEVLYTSGLVSILLSLLSDTEGYVRASAVTAVGEAVTSSVQQMALVSKINLLEEALAQMMIILSQDTEGFPRRAVVKTFTSWLKGSNPITALDSSLSSVLSLGGNDFDWEVKMHTLELAEALMEKMLTCCPYAVQSFSSSERTRLTQSLSKLKDLGLFDVLLNGLFDCDRPVCEKSCQLLLKLKRLNAEKADFDHDALVLKACGNRWGDEVQSRFLNKQQVKASEHVLIGGGEGTEKDLHCIKEIPLSVILQILDLDDMQRMLKLSSDHVVNSPRSLMEDILSAAQQSEENIVDCY", "length": 822 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6PJG6-1", "protein_name": "Integrator complex assembly factor BRAT1", "gene_name": "BRAT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPECAQLLPALCAVLVDPRQPVADDTCLEKLLDWFKTVTEGESSVVLLQEHPCLVELLSHVLKVQDLSSGVLSFSLRLAGTFAAQENCFQYLQQGELLPGLFGEPGPLGRATWAVPTVRSGWIQGLRSLAQHPSALRFLADHGAVDTIFSLQGDSSLFVASAASQLLVHVLALSMRGGAEGQPCLPGGDWPACAQKIMDHVEESLCSAATPKVTQALNVLTTTFGRCQSPWTEALWVRLSPRVACLLERDPIPAAHSFVDLLLCVARSPVFSSSDGSLWETVARALSCLGPTHMGPLALGILKLEHCPQALRTQAFQVLLQPLACVLKATVQAPGPPGLLDGTADDATTVDTLLASKSSCAGLLCRTLAHLEELQPLPQRPSPWPQASLLGATVTVLRLCDGSAAPASSVGGHLCGTLAGCVRVQRAALDFLGTLSQGTGPQELVTQALAVLLECLESPGSSPTVLKKAFQATLRWLLSSPKTPGCSDLGPLIPQFLRELFPVLQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCALLASEVPQLALQLLQDPESYVRASAVTAMGQLSSQGLHAPTSPEHAEARQSLFLELLHILSVDSEGFPRRAVMQVFTEWLRDGHADAAQDTEQFVATVLQAASRDLDWEVRAQGLELALVFLGQTLGPPRTHCPYAVALPEVAPAQPLTEALRALCHVGLFDFAFCALFDCDRPVAQKSCDLLLFLRDKIASYSSLREARGSPNTASAEATLPRWRAGEQAQPPGDQEPEAVLAMLRSLDLEGLRSTLAESSDHVEKSPQSLLQDMLATGGFLQGDEADCY", "length": 821 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C3R1-1", "protein_name": "Integrator complex assembly factor BRAT1", "gene_name": "Brat1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPECSRLLPALCAVLADPRQLVADDTCLEKLLDWFKTVTEAESSLQLLQDHPCLMELLSHVLKPQDVSPRVLSFALRLVGVFAAQEDCFEYLQQGELLLGLFGESGAPGWAAWSIPSVRSGWIQGLCYLAHHPSALHFLADSGAVDTLFSLQGDPSLFVASAASQLLVHILALSMQGGAPGSPVPEAAAWPMCAQKIVNHVDESLHAKATPQVTQALNVLTTTFGRCHNPWTGVLWERLSPPVARLFERDPIPAVHALMDLLLSVARSPVLNFAACGLWEMLAQTLSRLSPIQAGPLALGTLKLQHCPQELRTQAFGVLLQPLACILKATTQAPGPPGLLDGTVGSLLTVDILLASKSACVGLLCQTLAHLEELQMLPQCPSPWPQVHLLQAALTILHLCDGSADPSSSAGGRLCGTLGGCVRVQRAALDFLGTLSQGTSPLELVLEVFAVLLKTLESPESSPMVLKKAFQATLRWLQNPHKTPSSSDLSSDALLFLGELFPILQKRLCSPCWEVRDSALEFLTHLIRHWGGQADFREALRSSEVPTLALQLLQDPESYVRASAVGAAGQLSSQGLQAAPASPENSQAQQGLLMDLMHILSTDSEGFPRRAVLRVFTDWLRDGHADVVRDTEWFVATVLQAVSRDLDWEVRVQGLELARVFLTQALGQPSLHCPYTVGLPRASSPRPHPEFLQTLCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTVPCSSPREAGDSPNSASVEAALQRWREGEQAQPLGDLDPEAMLAILRALDLEGLQGRLAKSSDHVEKSPQSLLQDMLATVGVLEENEADCY", "length": 822 }, "evidence": [ { "id": "F1N1C8", "url": "https://omabrowser.org/oma/group/F1N1C8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N1C8", "url": "https://www.uniprot.org/uniprotkb/F1N1C8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1C8", "url": "https://www.uniprot.org/uniprotkb/F1N1C8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "F1N1C8", "url": "https://www.uniprot.org/uniprotkb/F1N1C8" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "F1N1C8", "url": "https://www.uniprot.org/uniprotkb/F1N1C8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1C8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 814, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1C8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1C8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 401, "end_pos": 403 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q4T4-1", "uniprot_ac": "F6Q4T4", "uniprot_id": "F6Q4T4_BOVIN", "mass": { "chemical_mass": 86742.0, "monoisotopic_mass": 86742.0 }, "refseq": { "ac": "NP_001341293", "name": "ralBP1-associated Eps domain-containing protein 1 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341293" }, "gene_names": [ { "name": "REPS1", "type": "recommended", "evidence": [ { "id": "F6Q4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ] }, { "name": "REPS1", "type": "synonym", "evidence": [ { "id": "NP_001341293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341293" } ] } ], "protein_names": [ { "name": "RALBP1 associated Eps domain containing 1", "type": "synonym", "evidence": [ { "id": "F6Q4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4/entry#names_and_taxonomy" } ] }, { "name": "ralBP1-associated Eps domain-containing protein 1 isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001341293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341293" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REPS1", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4", "locus": { "chromosome": "9", "start_pos": 76639361, "end_pos": 76728983, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012299", "url": "https://www.ensembl.org/id/ENSBTAG00000012299" } ] } } ], "crossref": [ { "id": "F6Q4T4", "url": "https://alphafold.ebi.ac.uk/entry/F6Q4T4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012299", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012299", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00052", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00052", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536155", "url": "https://www.ncbi.nlm.nih.gov/gene/536155", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QCCDVEN", "url": "https://omabrowser.org/oma/group/QCCDVEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZ35", "url": "https://www.orthodb.org/?gene=A0A3Q1LZ35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6Q4T4", "url": "https://www.orthodb.org/?gene=F6Q4T4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11216:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11216:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001341293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341293", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ35-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q4T4-1", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVSANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHPTSYSSDSENQGSYSGVIPPPPGRGQVKKGSTSHDTVQPRASVDQQEPVSPVVSPQQSPPASPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTANEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKTSDLSEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGNNVTRQRSHSGTSPENTAPPPPPPRPQPSHSRSSSLDMNRTFSVTTGQQQAGVVAQPPAVPPRPQPSQAPGPVVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNEEQDDEAEKHPEVLPVEKSSDPASSRVAKTDSKIEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 795, "header": "tr|F6Q4T4-1|F6Q4T4_BOVIN Isoform 1 of RALBP1 associated Eps domain containing 1 OS=Bos taurus OX=9913 GN=REPS1 PE=4 SV=2 CANONICAL=F6Q4T4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ35-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ35/entry", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVSANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHPTSYSSDSENQGSYSGVIPPPPGRGQVKKGSTSHDTVQPRASVDQQEPVSPVVSPQQSPPASPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTANEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKTSDLSEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGNNVTRQRSHSGTSPENTAPPPPPPRPQPSHSRSSSLDMNRTFSVTTGQQQAGVVAQPPAVPPRPQPSQAPGPVVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNEEQDDEAEKHPEVLPVEKSSDPASSRVAKTDSKIEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 768, "header": "tr|A0A3Q1LZ35-1|F6Q4T4_BOVIN Computationally mapped isoform of RALBP1 associated Eps domain containing 1 OS=Bos taurus OX=9913 GN=REPS1 PE=4 SV=1 CANONICAL=F6Q4T4-1" }, "locus": { "chromosome": "9", "start_pos": 76728792, "end_pos": 76639563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067633.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067633.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062881.1" } ] } }, { "isoform_ac": "A0AAA9SF71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF71/entry", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVSANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHPTSYSSDSENQGSYSGVIPPPPGRGQVKKGSTSHDTVQPRASVDQQEPVSPVVSPQQSPPASPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGNSQTLIKMEP", "length": 220, "header": "tr|A0AAA9SF71-1|F6Q4T4_BOVIN Computationally mapped isoform of RALBP1 associated Eps domain containing 1 OS=Bos taurus OX=9913 GN=REPS1 PE=4 SV=1 CANONICAL=F6Q4T4-1" }, "locus": { "chromosome": "9", "start_pos": 76728792, "end_pos": 76682208, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095016.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095016.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082482.1" } ] } }, { "isoform_ac": "A0AAA9SPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF2/entry", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVSANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHPTSYSSDSENQGSYSGVIPPPPGRGQVKKGSTSHDTVQPRASVDQQEPVSPVVSPQQSPPASPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTANEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKTSDLSEENKINSSVKFASGNTVGQQQAGVVAQPPAVPPRPQPSQAPGPVVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNEEQDDEAEKHPEVLPVEKSSDPASSRVAKTDSKIEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 704, "header": "tr|A0AAA9SPF2-1|F6Q4T4_BOVIN Computationally mapped isoform of RALBP1 associated Eps domain containing 1 OS=Bos taurus OX=9913 GN=REPS1 PE=4 SV=1 CANONICAL=F6Q4T4-1" }, "locus": { "chromosome": "9", "start_pos": 76728792, "end_pos": 76639563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087229.1" } ] } }, { "isoform_ac": "A0AAA9ST91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST91/entry", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVSANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHPTSYSSDSENQGSYSGVIPPPPGRGQVKKGSTSHDTVQPRASVDQQEPVSPVVSPQQSPPASPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTANEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKTSDLSEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGNNVTRQRSHSGTSPENTAPPPPPPRPQPSHSRSSSLDMNRTFSVTTGQQQAGVVAQPPAVPPRPQPSQAPGPVVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNEEQDDEAEKHPEVLPSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 737, "header": "tr|A0AAA9ST91-1|F6Q4T4_BOVIN Computationally mapped isoform of RALBP1 associated Eps domain containing 1 OS=Bos taurus OX=9913 GN=REPS1 PE=4 SV=1 CANONICAL=F6Q4T4-1" }, "locus": { "chromosome": "9", "start_pos": 76728792, "end_pos": 76639563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115989.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115989.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089637.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089637.1" } ] } }, { "isoform_ac": "F6Q4T4-1", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4/entry", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVSANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHPTSYSSDSENQGSYSGVIPPPPGRGQVKKGSTSHDTVQPRASVDQQEPVSPVVSPQQSPPASPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTANEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKTSDLSEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGNNVTRQRSHSGTSPENTAPPPPPPRPQPSHSRSSSLDMNRTFSVTTGQQQAGVVAQPPAVPPRPQPSQAPGPVVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNEEQDDEAEKHPEVLPVEKSSDPASSRVAKTDSKIEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 795, "header": "tr|F6Q4T4-1|F6Q4T4_BOVIN Isoform 1 of RALBP1 associated Eps domain containing 1 OS=Bos taurus OX=9913 GN=REPS1 PE=4 SV=2 CANONICAL=F6Q4T4-1" }, "locus": { "chromosome": "9", "start_pos": 76728792, "end_pos": 76639563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016319.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016319.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016319.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016319.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B7S1-1", "protein_name": "RalBP1-associated Eps domain-containing protein 1 isoform X1", "gene_name": "reps1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MESLTLSDVEQKYYSELFLSCDVDNAKKVASNGKVLELFRAAQLSNEVVLQITELCGATRLGHFGRSQFYIALKLIALAQSGLPLRLESLNTVRDLPLPRFVMGKNEQETRHMVMFTDAENQGPFLPRPPGRVQAKKVSAHEMIQPCVPTADPQPDTTSPVVSPHQSPPTSPLAWRKHKRQASGGNVDRQPSVPGVVWPHFREAQPGPVPGDGMWSAHSPPPVQESWVSFTDTPPSSTLPMHPPSAQTESSTVRTVPSAMTTNEIQRQTSGYDDPWKITDEQRQYYINQFKTIQADLTGLIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLDDSAGVPEPAPEVGFSASPVEVTPNKSPSMPSLNQNWPELNQSNEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTHPTSPLMTKPPELSDETKLAAAIKFPGTAVGDGYSSSDSFTSDQEPISSAVNRQRSHSGTSPEGLKVVAPPPPPPRPHASHSRSSSLDMNRNFAAVPAAGSQQAGVVAFPPAVPPRPLPTQTSVPHGHRSVEGDGLPAHTSTSPQQMPEQPNFADFSQFKAFAVDQPADDGENPSDGGQAERLPEAAGTMRTAKNDVQAEERNATTVNSAKVSTPLAPPPKPVRRRLKSEDELRPDVDDLPQKSNVIATVLATQPSIPRSLGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDLLEERISLEVQLEQLRPFSHL", "length": 791 }, "evidence": [ { "id": "F6Q4T4", "url": "https://omabrowser.org/oma/group/F6Q4T4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S6Z2-1", "protein_name": "RALBP1 associated Eps domain containing 1", "gene_name": "REPS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVAANGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHTASYSSDSENQGSYSGVIPPPPGRGQVKKGSISHDPVQPRVSADQQEPASPVVSPQQSPPTSPHTWRKHNRHPSGGNSERPLAGPGPFWSPFGEAQSGSSTGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTANEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTSSDHTNPTSPLLVKTSDLSEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGNNVTRQRSQSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFSVTTGQQQAGVVAQPPAVPPRPQPSQAPGPVVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNEEQGDEAEKHPEVLVEKASDPASSLRVAKTDSKIEEKTAAIAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEIDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 795 }, "evidence": [ { "id": "F6Q4T4", "url": "https://omabrowser.org/oma/group/F6Q4T4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O54916-1", "protein_name": "RalBP1-associated Eps domain-containing protein 1", "gene_name": "Reps1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRLAASYSSDSENQGSYSGVIPPPPGRGQVKKGPGSHDAVQPRPSAEQQEPVSPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLTGPGPFWSPFGDAQAGSSAGDAVWSGQSPPPPQDNWVSFADTPPTSALLTMHPASVQDQTTVRTVASAATANEIRRQSSSYEDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGEQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTSSDHTNPTSPLLVKPSDLSEENKINSSVKFPSGNTVDGYSSSDSFPSDPEQIGSSVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFAVTTGQQQAGVVAHPPAVPPRPQPSQAPGPSVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVSEEQDSEAEKHPEVLPAEKASDPSSSLRAAQADSKAEEKTATNVPANVSKGTTPLAPPPKPVRRRLKSEDELRPDVDEHTQKTGVLAAVLTSQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 795 }, "evidence": [ { "id": "F6Q4T4", "url": "https://omabrowser.org/oma/group/F6Q4T4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96D71-1", "protein_name": "RalBP1-associated Eps domain-containing protein 1", "gene_name": "REPS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL", "length": 796 }, "evidence": [ { "id": "F6Q4T4", "url": "https://omabrowser.org/oma/group/F6Q4T4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" }, { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "F6Q4T4", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6Q4T4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 795, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6Q4T4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6Q4T4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6Q4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 318, "end_pos": 353, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6Q4T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q4T4" }, { "id": "PS50031", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50031" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EH", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 113, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 408, "end_pos": 410 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 498, "end_pos": 500 }, { "start_pos": 529, "end_pos": 531 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 687, "end_pos": 689 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Y1-1", "uniprot_ac": "F1N6Y1", "uniprot_id": "F1N6Y1_BOVIN", "mass": { "chemical_mass": 109472.0, "monoisotopic_mass": 109472.0 }, "refseq": { "ac": "NP_001192706", "name": "neutral alpha-glucosidase AB", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192706" }, "gene_names": [ { "name": "GANAB", "type": "recommended", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ] }, { "name": "GANAB", "type": "synonym", "evidence": [ { "id": "NP_001192706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192706" } ] } ], "protein_names": [ { "name": "Neutral alpha-glucosidase AB", "type": "recommended", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.207", "type": "synonym", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1/entry#names_and_taxonomy" } ] }, { "name": "Alpha-glucosidase 2", "type": "synonym", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1/entry#names_and_taxonomy" } ] }, { "name": "Glucosidase II subunit alpha", "type": "synonym", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1/entry#names_and_taxonomy" } ] }, { "name": "glucosidase, alpha", "type": "synonym", "evidence": [ { "id": "NP_001192706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192706" } ] }, { "name": "neutral AB", "type": "synonym", "evidence": [ { "id": "NP_001192706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192706" } ] }, { "name": "neutral alpha-glucosidase AB", "type": "synonym", "evidence": [ { "id": "NP_001192706", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192706" } ] } ], "function": [ { "annotation": "Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZU8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU8#function" }, { "database": "UniProtKB", "id": "ARBA00058913", "url": "https://www.uniprot.org/uniprotkb/ARBA00058913#function" }, { "database": "UniProtKB", "id": "A0A3Q1N1T6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1T6#function" }, { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1#function" }, { "database": "UniProtKB", "id": "A0AAA9SVL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GANAB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1", "locus": { "chromosome": "29", "start_pos": 40966912, "end_pos": 40982246, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016956", "url": "https://www.ensembl.org/id/ENSBTAG00000016956" } ] } } ], "crossref": [ { "id": "F1N6Y1", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Y1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016956", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06603", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06603", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14752", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14752", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540155", "url": "https://www.ncbi.nlm.nih.gov/gene/540155", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540155", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540155", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HWALGYH", "url": "https://omabrowser.org/oma/group/HWALGYH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZU8", "url": "https://www.orthodb.org/?gene=A0A3Q1LZU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N1T6", "url": "https://www.orthodb.org/?gene=A0A3Q1N1T6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N6Y1", "url": "https://www.orthodb.org/?gene=F1N6Y1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22762:SF162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22762:SF162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13802", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13802", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21365", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21365", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9768727", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192706", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "55996", "url": "https://www.rhea-db.org/rhea/55996", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56000", "url": "https://www.rhea-db.org/rhea/56000", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZU8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZU8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1T6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1T6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1T6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y1-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIAAVEARRRRSWTALVLACLGVCLGITFAVDRSNFKTCEESSFCKRQRSIRPGHSPYRALLDSLQLGPDALTVHLINEVTKVVLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTAGLSVSGRDDNSVELTVAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLNLEHQRTPRVSFSDKVSLTLGSIWDRIKNVFSRQGSKEPAEGDGAQPEETPGDDNKPDETQGKPEHDEPGAWEETFKTHSDSKPYGPTSVSLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNRMALYGSVPVLLAHSPLRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDVRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELQNLGLYVKTRDGSDYEGWCWPGAAGYPDFTNPKMRAWWANMFHFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLVLRSGGIERPFVLSRAFFAGSQRFGAVWTGDNAAEWDHMKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQYHEIIRDALGQRYSLLPFWYTLFYQSHREGIPVMRPLWVHYPKDVTTFSIDDQFLLGDALLVHPVSDSEARGVQVYLPGQGEVWYDVQSYQKYHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSLQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGNTLVSSSADPKGHFETPIWIERVVIIGAGKPATVVLQTKGSPESRLSFQHDPETSVLILRKPGVNVASDWTIHLR", "length": 966, "header": "tr|F1N6Y1-1|F1N6Y1_BOVIN Isoform 1 of Neutral alpha-glucosidase AB OS=Bos taurus OX=9913 GN=GANAB PE=1 SV=1 CANONICAL=F1N6Y1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZU8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU8/entry", "sequence": { "sequence": "MAAIAAVEARRRRSWTALVLACLGVCLGITFAVDRSNFKTCEESSFCKRQRSIRPGHSPYRALLDSLQLGPDALTVHLINEVTKVVLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTAGLSVSGRDDNSVELTVAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLNLEHQRTPRVSQGSKEPAEGDGAQPEETPGDDNKPDETQGKPEHDEPGAWEETFKTHSDSKPYGPTSVSLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNRMALYGSVPVLLAHSPLRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDVRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELQNLGLYVKTRDGSDYEGWCWPGAAGYPDFTNPKMRAWWANMFHFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLVLRSGGIERPFVLSRAFFAGSQRFGAVWTGDNAAEWDHMKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQYHEIIRDALGQRYSLLPFWYTLFYQSHREGIPVMRPLWVHYPKDVTTFSIDDQFLLGDALLVHPVSDSEARGVQVYLPGQGEVWYDVQSYQKYHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSLQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGNTLVSSSADPKGHFETPIWIERVVIIGAGKPATVVLQTKGSPESRLSFQHDPETSVLILRKPGVNVASDWTIHLR", "length": 944, "header": "tr|A0A3Q1LZU8-1|F1N6Y1_BOVIN Computationally mapped isoform of Neutral alpha-glucosidase AB OS=Bos taurus OX=9913 GN=GANAB PE=1 SV=1 CANONICAL=F1N6Y1-1" }, "locus": { "chromosome": "29", "start_pos": 40982243, "end_pos": 40967896, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067012.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067012.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062873.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062873.1" } ] } }, { "isoform_ac": "A0A3Q1N1T6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1T6/entry", "sequence": { "sequence": "MAAIAAVEARRRRSWTALVLACLGVCLGITFAVDRSNFKTCEESSFCKRQRSIRPGHSPYRALLDSLQLGPDALTVHLINEVTKVVLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTAGLSVSGRDDNSVELTVAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLNLEHQRTPRVSFSDKVSLTLGSIWDRIKNVFSRQGSKEPAEGDGAQPEETPGDDNKPDETQGKPEHDEPGAWEETFKTHSDSKPYGPTSVSLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNRMALYGSVPVLLAHSPLRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDVRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELQNLGLYVKTRDGSDYEGWCWPGAAGYPDFTNPKMRAWWANMFHFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLVLRSGGIERPFVLSRAFFAGSQRFGAVWTGDNAAEWDHMKISIPMCLSLGLVGLSFCGGRGLGGLLKPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQYHEIIRDALGQRYSLLPFWYTLFYQSHREGIPVMRPLWVHYPKDVTTFSIDDQFLLGDALLVHPVSDSEARGVQVYLPGQGEVWYDVQSYQKYHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSLQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGNTLVSSSADPKGHFETPIWIERVVIIGAGKPATVVLQTKGSPESRLSFQHDPETSVLILRKPGVNVASDWTIHLR", "length": 964, "header": "tr|A0A3Q1N1T6-1|F1N6Y1_BOVIN Computationally mapped isoform of Neutral alpha-glucosidase AB OS=Bos taurus OX=9913 GN=GANAB PE=1 SV=1 CANONICAL=F1N6Y1-1" }, "locus": { "chromosome": "29", "start_pos": 40982243, "end_pos": 40967896, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069247.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069247.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063092.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063092.1" } ] } }, { "isoform_ac": "A0AAA9SVL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL8/entry", "sequence": { "sequence": "MAAIAAVEARRRRLSVSGRDDNSVELTVAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLNLEHQRTPRVSFSDKVSLTLGSIWDRIKNVFSRQGSKEPAEGDGAQPEETPGDDNKPDETQGKPEHDEPGAWEETFKTHSDSKPYGPTSVSLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNRMALYGSVPVLLAHSPLRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDVRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELQNLGLYVKTRDGSDYEGWCWPGAAGYPDFTNPKMRAWWANMFHFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLVLRSGGIERPFVLSRAFFAGSQRFGAVWTGDNAAEWDHMKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQYHEIIRDALGQRYSLLPFWYTLFYQSHREGIPVMRPLWVHYPKDVTTFSIDDQFLLGDALLVHPVSDSEARGVQVYLPGQGEVWYDVQSYQKYHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSLQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGNTLVSSSADPKGHFETPIWIERVVIIGAGKPATVVLQTKGSPESRLSFQHDPETSVLILRKPGVNVASDWTIHLR", "length": 852, "header": "tr|A0AAA9SVL8-1|F1N6Y1_BOVIN Computationally mapped isoform of Neutral alpha-glucosidase AB OS=Bos taurus OX=9913 GN=GANAB PE=1 SV=1 CANONICAL=F1N6Y1-1" }, "locus": { "chromosome": "29", "start_pos": 40982243, "end_pos": 40967896, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097634.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097634.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088235.1" } ] } }, { "isoform_ac": "F1N6Y1-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1/entry", "sequence": { "sequence": "MAAIAAVEARRRRSWTALVLACLGVCLGITFAVDRSNFKTCEESSFCKRQRSIRPGHSPYRALLDSLQLGPDALTVHLINEVTKVVLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTAGLSVSGRDDNSVELTVAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLNLEHQRTPRVSFSDKVSLTLGSIWDRIKNVFSRQGSKEPAEGDGAQPEETPGDDNKPDETQGKPEHDEPGAWEETFKTHSDSKPYGPTSVSLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNRMALYGSVPVLLAHSPLRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDVRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWDPSRFPQPRNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELQNLGLYVKTRDGSDYEGWCWPGAAGYPDFTNPKMRAWWANMFHFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLVLRSGGIERPFVLSRAFFAGSQRFGAVWTGDNAAEWDHMKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQYHEIIRDALGQRYSLLPFWYTLFYQSHREGIPVMRPLWVHYPKDVTTFSIDDQFLLGDALLVHPVSDSEARGVQVYLPGQGEVWYDVQSYQKYHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSLQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGNTLVSSSADPKGHFETPIWIERVVIIGAGKPATVVLQTKGSPESRLSFQHDPETSVLILRKPGVNVASDWTIHLR", "length": 966, "header": "tr|F1N6Y1-1|F1N6Y1_BOVIN Isoform 1 of Neutral alpha-glucosidase AB OS=Bos taurus OX=9913 GN=GANAB PE=1 SV=1 CANONICAL=F1N6Y1-1" }, "locus": { "chromosome": "29", "start_pos": 40982243, "end_pos": 40967896, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022558.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022558.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022558.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022558.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 125, "start_aa": "Thr", "end_pos": 125, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr125", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540155", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540155", "resource": "KEGG Pathway" }, { "id": "R-BTA-9768727", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "resource": "Reactome", "description": "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAN3-1", "protein_name": "Neutral alpha-glucosidase AB", "gene_name": "Ganab", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAIAAVAARRRRSWLSLVLAYLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPYRALLDTLQLGPDALTVHLTHEVTKVLLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPATARLSISGRDDNSVELTVAEGPYKIILTAKPFRLDLLEDRSLLLSVNARGLMAFEHQRAPRVPFSDKVSLTLGSMWDKIKNLFSRQEPKDAAEGNGAEPEARPGDGDKAKETQEKAEKDEPGAWEETFKTHSDSKPYGPTSVGLDFSLPGMEHVYGIPEHADSLRLKVTEGGEPYRLYNLDVFQYELNNPMALYGSVPVLLAHSFHRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDIRWMSESGIVDVFLMLGPSVLDVFRQHASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNMPCDVIWLDIEHADGKRYFTWDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELRNHGLYVKTRDGSDYEGWCWPGSASYPDFTNPQMRAWWANMFNFHNYEGSAPNLFVWNDMNEPSVFNGPEVTMLKDAVHYGGWEHRDIHNIYGLYVHMATADGLIQRSGGIERPFVLSRAFFSGSQRFGAVWTGDNTAEWDHLKISIPMCLSLALVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLASQYQDAIRDALFQRYSLLPFWYTLFYQAHQEGFPVMRPLWVQYPEDMSTFSMEDQFMLGDALLIHPVSDAGAHGVQVYLPGEEEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKEDPITLFVALSAQGTAQGELFLDDGHTFNYQNRHEFLLRRFSFSGNTLVSSSADPKGHLETPVWIERVVIMGAGKPAAVVLQTKGSPESRLSFQHDPETSVLTLRKPGVNVASDWSIHLR", "length": 966 }, "evidence": [ { "id": "F1N6Y1", "url": "https://omabrowser.org/oma/group/F1N6Y1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q6Z9-1", "protein_name": "Neutral alpha-glucosidase AB", "gene_name": "ganabb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAANSIERMGLLSVLCVSLFFSSTFAVDRGSFKTCDQSSFCKRQRTLKPGQSPYRALLDTLELSDSRLTLQLINDNNKVHLLLELYRLQGNMTRVKINELKPLKPRFEVPDVLIADPPTEPLSVLSQDDNGLVLSLGAESQRLIVSARPFRLDIMEGPEVLLSLNSRGLLAFEHLRLRKDTQAQPDGAEVKESTEADQQQAEGEKDEDGENDKDEDGLWDESFKAHADTKPNGPTSISLDFSLPGVEHVYGIPEHADNLKLKTTDGGDPYRLYNLDVFQYELYNPMALYGSVPVMIAHNTQRTMGIFWLNAAETWVDISSNTAGKTVFGKMLDFVQGSSETPQTDVRWISESGIIDVFIMLGPKPSDVFSQYASLTGTQSFPPLASLAYHQCRWNYNDQDDVKSVDEGFDQHDIPYDFIWLDIEHADGKRYFTWDPHKFPEPKEMLQGLMEKRRKMVAIVDPHIKVDSDYKIHNEITNKDFYVKNSDGRNYEGWCWPGNSGYPDFTNPEMRAWWASMFSYDQYEGSMENLFTWNDMNEPSVFNGPEITMHKDAIHGKWEHRDVHNIYGLYVQKATAEGQIQRSGGVERPFVLTRAFFAGSQRYGAVWTGDNAADWGHLKISIPMCLSLGLVGISFCGADVGGFFNNPSTELLVRWYQTGAYQPFFRAHAHLDTTRREPWLFGPENTALIREAIRQRYALLPYWYQLIYQAHTTGMPVMRPLWVDYPKETATFTIDDEFLIGRDLLVHPVTEEGSRGVTAYLPGAGEVWYDVHTFQKHNGAQNLYIPVTLSSIPVFQRGGSIIPRKDRIRRSSACMENDPYTLYVALSPKKFAEGELYIDDGHSFNYDTKSEFIHRKLTFANNSLTSRNLCPDCKFSTSSWVEKVVILGASKPRKVLLKVDGKETPVEFEFDASMSVLTLRKPGINAGMDWTILLQSQRNDL", "length": 941 }, "evidence": [ { "id": "F1N6Y1", "url": "https://omabrowser.org/oma/group/F1N6Y1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BHN3-1", "protein_name": "Neutral alpha-glucosidase AB", "gene_name": "Ganab", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAIAAVAARRRRSWLSLVLAYLGVCLGITLAVDRSNFKTCDESSFCKRQRSIRPGLSPYRALLDTLQLGPDALTVHLIHEVTKVLLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTARLSVSGRDDNSVELTVAEGPYKIILTAQPFRLDLLEDRSLLLSVNARGLMAFEHQRAPRVPQESKDPAEGNGAQPEATPGDGDKPEETQEKAEKDEPGAWEETFKTHSDSKPYGPTSVGLDFSLPGMEHVYGIPEHADSLRLKVTEGGEPYRLYNLDVFQYELNNPMALYGSVPVLLAHSFHRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDIRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNMPCDVIWLDIEHADGKRYFTWDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELRNHGLYVKTRDGSDYEGWCWPGSASYPDFTNPRMRAWWSNMFSFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAVHYGGWEHRDIHNIYGLYVHMATADGLIQRSGGIERPFVLSRAFFSGSQRFGAVWTGDNTAEWDHLKISIPMCLSLALVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLASQYQDAIRDALFQRYSLLPFWYTLFYQAHKEGFPVMRPLWVQYPEDMSTFSIEDQFMLGDALLIHPVSDAGAHGVQVYLPGQEEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGSTLVSSSADPKGHLETPIWIERVVIMGAGKPAAVVLQTKGSPESRLSFQHDPETSVLILRKPGVSVASDWSIHLR", "length": 944 }, "evidence": [ { "id": "F1N6Y1", "url": "https://omabrowser.org/oma/group/F1N6Y1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" }, { "name": "glucosidase II complex", "id": "GO:0017177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017177", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" }, { "name": "N-glycan processing", "id": "GO:0006491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" }, { "name": "glucan 1,3-alpha-glucosidase activity", "id": "GO:0033919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033919", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" }, { "name": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "id": "GO:0106407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106407", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "55996", "name": "", "equation": "N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6Y1-1" ], "evidence": [ { "id": "55996", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55996" } ] }, { "id": "56000", "name": "", "equation": "N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + beta-D-glucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6Y1-1" ], "evidence": [ { "id": "56000", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56000" } ] }, { "id": "R-BTA-9932352", "name": "Glucosidase II removes glucose residue from Glu2Man9GlucNAc2-CDH1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-BTA-9932341" ], "output_participant_list": [ "R-BTA-9932915" ], "enzyme_list": [ "F1N6Y1-1" ], "evidence": [ { "id": "R-BTA-9932352", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932352" } ] }, { "id": "R-BTA-9932913", "name": "Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-BTA-9932989" ], "enzyme_list": [ "F1N6Y1-1" ], "evidence": [ { "id": "R-BTA-9932913", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932913" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-9932341", "participant_name": "CDH1 [endoplasmic reticulum membrane]", "crossref": [ { "id": "A0A3Q1MSS6", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000073179", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000087488", "database": "ENSEMBL", "url": "" }, { "id": "27090", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000015991", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-9932915", "participant_name": "CDH1 [endoplasmic reticulum membrane]", "crossref": [ { "id": "ENSBTAT00000087488", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1MSS6", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000015991", "database": "ENSEMBL", "url": "" }, { "id": "27090", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000073179", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-9932989", "participant_name": "CANX [endoplasmic reticulum membrane]", "crossref": [ { "id": "26736", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000064711", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000048107", "database": "ENSEMBL", "url": "" }, { "id": "NP_001099082.1", "database": "RefSeq", "url": "" }, { "id": "A7Z066", "database": "UniProt", "url": "" }, { "id": "XP_059743936.1", "database": "RefSeq", "url": "" }, { "id": "XP_059743935.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000054517", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1N6Y1", "gene_name": "GANAB", "activity": [ { "ec_number": "3.2.1.207", "activity": "N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + beta-D-glucose.", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ] }, { "ec_number": "3.2.1.207", "activity": "", "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Y1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 966, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Y1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Y1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" }, { "id": "PF13802", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13802" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycoside hydrolase family 31 N-terminal", "eco_id": "ECO_0000259", "start_pos": 89, "end_pos": 346, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" }, { "id": "PF01055", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01055" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycoside hydrolase family 31 TIM barrel", "eco_id": "ECO_0000259", "start_pos": 409, "end_pos": 736, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y1" }, { "id": "PF21365", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21365" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycosyl hydrolase family 31 C-terminal", "eco_id": "ECO_0000259", "start_pos": 744, "end_pos": 832, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.207", "ec_name": "N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + beta-D-glucose.", "evidence": [ { "id": "3.2.1.207", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.207" }, { "id": "3.2.1.207", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.207" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 125 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6T8-1", "uniprot_ac": "F1N6T8", "uniprot_id": "F1N6T8_BOVIN", "mass": { "chemical_mass": 101228.0, "monoisotopic_mass": 101228.0 }, "refseq": {}, "gene_names": [ { "name": "VAV2", "type": "recommended", "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ] } ], "protein_names": [ { "name": "Guanine nucleotide exchange factor VAV2", "type": "recommended", "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MQP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQP9#function" }, { "database": "UniProtKB", "id": "ARBA00058236", "url": "https://www.uniprot.org/uniprotkb/ARBA00058236#function" }, { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8#function" }, { "database": "UniProtKB", "id": "A0AAA9STZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ4#function" }, { "database": "UniProtKB", "id": "A0A3Q1M182", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M182#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VAV2", "url": "https://www.uniprot.org/uniprotkb/F1N6T8", "locus": { "chromosome": "11", "start_pos": 104590862, "end_pos": 104778132, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004511", "url": "https://www.ensembl.org/id/ENSBTAG00000004511" } ] } } ], "crossref": [ { "id": "F1N6T8", "url": "https://alphafold.ebi.ac.uk/entry/F1N6T8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004511", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004511", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10406", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10406", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11977", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11977", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11980", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11980", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20868", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20868", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515718", "url": "https://www.ncbi.nlm.nih.gov/gene/515718", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022613", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022613", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45818:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45818:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11971", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11971", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2424491", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2424491", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871796", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871796", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871809", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871809", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4420097", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4420097", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9958810", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9958810", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M182", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M182", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M182-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M182-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T744", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T744", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T744-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T744-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6T8-1", "url": "https://www.uniprot.org/uniprotkb/F1N6T8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQWRQCGRWLIDCRVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDVNFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPASCASYNFSFLSPQGLGLASQGSSTPFWSVFTPRVIGTAVARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKGETSGRVGWFPSTYVEEEGVQ", "length": 878, "header": "tr|F1N6T8-1|F1N6T8_BOVIN Isoform 1 of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=4 CANONICAL=F1N6T8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M182-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M182/entry", "sequence": { "sequence": "MEQWRQCGRWLIDCRVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDVNFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPASCASYNFSFLSPQGLGLASQGSSTPFWSAVFTPRVIGTAVARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKGETSGRVGWFPSTYVEEEGVQ", "length": 869, "header": "tr|A0A3Q1M182-1|F1N6T8_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=2 CANONICAL=F1N6T8-1" }, "locus": { "chromosome": "11", "start_pos": 104777933, "end_pos": 104592024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067212.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067212.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061789.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061789.2" } ] } }, { "isoform_ac": "A0A3Q1MQP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQP9/entry", "sequence": { "sequence": "MEQWRQCGRWLIDCRVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDVNFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPAVFTPRVIGTAVARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKGETSGRVGWFPSTYVEEEGVQ", "length": 840, "header": "tr|A0A3Q1MQP9-1|F1N6T8_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=2 CANONICAL=F1N6T8-1" }, "locus": { "chromosome": "11", "start_pos": 104777933, "end_pos": 104592024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086853.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086853.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073942.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073942.2" } ] } }, { "isoform_ac": "A0AAA9STZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ4/entry", "sequence": { "sequence": "MEQWRQCGRWLIDCRVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDVNFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPGRLVSFNVCRRGGRPVTARSRTGLADFLGRVAPAMKSVSSSATQRGNARQPSSLQQPVGMGRGFRTYM", "length": 840, "header": "tr|A0AAA9STZ4-1|F1N6T8_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=1 CANONICAL=F1N6T8-1" }, "locus": { "chromosome": "11", "start_pos": 104777933, "end_pos": 104591866, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087473.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087473.1" } ] } }, { "isoform_ac": "A0AAA9T744-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T744/entry", "sequence": { "sequence": "MEQWRQCGRWLIDCRVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDVNFRPQMSQVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPVFTPRVIGTAVARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKGETSGRVGWFPSTYVEEEGVQ", "length": 800, "header": "tr|A0AAA9T744-1|F1N6T8_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=1 CANONICAL=F1N6T8-1" }, "locus": { "chromosome": "11", "start_pos": 104777933, "end_pos": 104592024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093724.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093724.1" } ] } }, { "isoform_ac": "A0AAA9TMQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMQ3/entry", "sequence": { "sequence": "MTCHWLAGPRSPCLDQGRPWPPLRPSGGFGEKMWACLPPGLFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPVFTPRVIGTAVARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKGETSGRVGWFPSTYVEEEGVQ", "length": 812, "header": "tr|A0AAA9TMQ3-1|F1N6T8_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=1 CANONICAL=F1N6T8-1" }, "locus": { "chromosome": "11", "start_pos": 104771102, "end_pos": 104592024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107607.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107607.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098261.1" } ] } }, { "isoform_ac": "F1N6T8-1", "url": "https://www.uniprot.org/uniprotkb/F1N6T8/entry", "sequence": { "sequence": "MEQWRQCGRWLIDCRVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDVNFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSDLFDPFDLFDVRDFGKVISAVSRLSLHSLAQNKGIRPFPSEETTENDEDVYRSLEELADEHGVGEDIYDCVPCEDDGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYVTPLRLVLSPVDMAAIFINLEDLIKVHHSFLRAIDVSMMAGGSSLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSTDRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRRGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACRMFLRGTFYQGYLCTKCGVGAHKECLEVTPPCKISSPADPDASGAGPGPKMVAVQNYHGNPAPPTKPALTFQTGDVIELLRGDPESQWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPLSREMDYTAYPWFAGNMERQQTDNLLKPHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWVHITEAKKFESLLELVEYYQYHSLKESFKQLDTTLKYPYKAWERTASRASSRSPASCASYNFSFLSPQGLGLASQGSSTPFWSVFTPRVIGTAVARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKGETSGRVGWFPSTYVEEEGVQ", "length": 878, "header": "tr|F1N6T8-1|F1N6T8_BOVIN Isoform 1 of Guanine nucleotide exchange factor VAV2 OS=Bos taurus OX=9913 GN=VAV2 PE=4 SV=4 CANONICAL=F1N6T8-1" }, "locus": { "chromosome": "11", "start_pos": 104777933, "end_pos": 104592024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005932.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005932.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005932.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005932.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-114604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114604", "resource": "Reactome", "description": "GPVI-mediated activation cascade" }, { "id": "R-BTA-2029482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "resource": "Reactome", "description": "Regulation of actin dynamics for phagocytic cup formation" }, { "id": "R-BTA-2424491", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2424491", "resource": "Reactome", "description": "DAP12 signaling" }, { "id": "R-BTA-2871796", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871796", "resource": "Reactome", "description": "FCERI mediated MAPK activation" }, { "id": "R-BTA-2871809", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871809", "resource": "Reactome", "description": "FCERI mediated Ca+2 mobilization" }, { "id": "R-BTA-3928665", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "resource": "Reactome", "description": "EPH-ephrin mediated repulsion of cells" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-4420097", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4420097", "resource": "Reactome", "description": "VEGFA-VEGFR2 Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" }, { "id": "R-BTA-9958810", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9958810", "resource": "Reactome", "description": "SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "regulation of intracellular signal transduction", "id": "GO:1902531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902531", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "immune response-regulating cell surface receptor signaling pathway", "id": "GO:0002768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002768", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" }, { "name": "epidermal growth factor receptor binding", "id": "GO:0005154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005154", "evidence": [ { "database": "UniProtKB", "id": "F1N6T8", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 789, "end_pos": 791, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6T8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 878, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6T8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6T8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 120, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 198, "end_pos": 376, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 405, "end_pos": 512, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" }, { "id": "PS50081", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50081" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phorbol-ester/DAG-type", "eco_id": "ECO_0000259", "start_pos": 523, "end_pos": 572, "start_aa": "His", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 673, "end_pos": 767, "start_aa": "Trp", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T8" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 586, "end_pos": 652, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 419, "end_pos": 421 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 789, "end_pos": 791 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7X3-1", "uniprot_ac": "F1N7X3", "uniprot_id": "F1N7X3_BOVIN", "mass": { "chemical_mass": 48468.0, "monoisotopic_mass": 48468.0 }, "refseq": {}, "gene_names": [ { "name": "NAP1L4", "type": "recommended", "evidence": [ { "id": "F1N7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ] } ], "protein_names": [ { "name": "Nucleosome assembly protein 1 like 4", "type": "synonym", "evidence": [ { "id": "F1N7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7X3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAP1L4", "url": "https://www.uniprot.org/uniprotkb/F1N7X3", "locus": { "chromosome": "29", "start_pos": 48676964, "end_pos": 48624071, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022160", "url": "https://www.ensembl.org/id/ENSBTAG00000022160" } ] } } ], "crossref": [ { "id": "F1N7X3", "url": "https://alphafold.ebi.ac.uk/entry/F1N7X3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022160", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022160", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1N7", "url": "https://www.orthodb.org/?gene=A0A3Q1M1N7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ME14", "url": "https://www.orthodb.org/?gene=A0A3Q1ME14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7X3", "url": "https://www.orthodb.org/?gene=F1N7X3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11875", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11875", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M1N7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1N7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1N7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7X3-1", "url": "https://www.uniprot.org/uniprotkb/F1N7X3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGVVGGHGGAVPERAKPRRLPLLPQEARGAAARARPGDKDIQMADNSFSDGVPSDSLEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVKCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSETEEEDKLAGDMKNKAVIAEKEAAAAEEPAPRGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNDSFFNFFSPLRASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEAEDDDDAEINPKKEPSQPSECKQQ", "length": 430, "header": "tr|F1N7X3-1|F1N7X3_BOVIN Isoform 1 of Nucleosome assembly protein 1 like 4 OS=Bos taurus OX=9913 GN=NAP1L4 PE=3 SV=3 CANONICAL=F1N7X3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1N7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1N7/entry", "sequence": { "sequence": "MSGGVVGGHGGAVPERAKPRRLPLLPQEARGDKDIQMADNSFSDGVPSDSLEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVKCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSETEEEDKLAGDMKNKAVIAEKEAAAAEEPAPRGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNDSFFNFFSPLRASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNVQSAPGARTRPAWRIQGLGKRPGHCSRISLGDAGCTDSDPM", "length": 422, "header": "tr|A0A3Q1M1N7-1|F1N7X3_BOVIN Computationally mapped isoform of Nucleosome assembly protein 1 like 4 OS=Bos taurus OX=9913 GN=NAP1L4 PE=3 SV=2 CANONICAL=F1N7X3-1" }, "locus": { "chromosome": "29", "start_pos": 48669241, "end_pos": 48624270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086965.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086965.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067269.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067269.2" } ] } }, { "isoform_ac": "A0A3Q1ME14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME14/entry", "sequence": { "sequence": "MAHGVPSDSLEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVKCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSETEEEDKLAGDMKNKAVIAEKEAAAAEEPAPRGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNDSFFNFFSPLRGDFPSQDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNVGGLGAGGLGGPAGGRCSLEPGAEGMAQCPSQPVQ", "length": 373, "header": "tr|A0A3Q1ME14-1|F1N7X3_BOVIN Computationally mapped isoform of Nucleosome assembly protein 1 like 4 OS=Bos taurus OX=9913 GN=NAP1L4 PE=3 SV=2 CANONICAL=F1N7X3-1" }, "locus": { "chromosome": "29", "start_pos": 48668528, "end_pos": 48643508, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086720.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086720.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069213.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069213.2" } ] } }, { "isoform_ac": "F1N7X3-1", "url": "https://www.uniprot.org/uniprotkb/F1N7X3/entry", "sequence": { "sequence": "MSGGVVGGHGGAVPERAKPRRLPLLPQEARGAAARARPGDKDIQMADNSFSDGVPSDSLEAAKNASNTEKLTDQVMQNPQVLAALQERLDNVSHTPSSYIETLPKAVKRRINALKQLQVKCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSETEEEDKLAGDMKNKAVIAEKEAAAAEEPAPRGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNPVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNDSFFNFFSPLRASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEAEDDDDAEINPKKEPSQPSECKQQ", "length": 430, "header": "tr|F1N7X3-1|F1N7X3_BOVIN Isoform 1 of Nucleosome assembly protein 1 like 4 OS=Bos taurus OX=9913 GN=NAP1L4 PE=3 SV=3 CANONICAL=F1N7X3-1" }, "locus": { "chromosome": "29", "start_pos": 48676000, "end_pos": 48624270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029894.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029894.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029889.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029889.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 161, "start_aa": "Thr", "end_pos": 161, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr161", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" }, { "name": "nucleosome binding", "id": "GO:0031491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "evidence": [ { "database": "UniProtKB", "id": "F1N7X3", "url": "https://www.uniprot.org/uniprotkb/F1N7X3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7X3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 430, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7X3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7X3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 161 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 64, "end_pos": 66 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5Q6-1", "uniprot_ac": "F1N5Q6", "uniprot_id": "F1N5Q6_BOVIN", "mass": { "chemical_mass": 25104.0, "monoisotopic_mass": 25104.0 }, "refseq": {}, "gene_names": [ { "name": "CRYBA1", "type": "recommended", "evidence": [ { "id": "F1N5Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6" } ] } ], "protein_names": [ { "name": "Crystallin beta A1", "type": "synonym", "evidence": [ { "id": "F1N5Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Crystallins are the dominant structural components of the vertebrate eye lens.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M246", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M246#function" }, { "database": "UniProtKB", "id": "ARBA00003689", "url": "https://www.uniprot.org/uniprotkb/ARBA00003689#function" }, { "database": "UniProtKB", "id": "F1N5Q6", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5Q6", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRYBA1", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6", "locus": { "chromosome": "19", "start_pos": 20591495, "end_pos": 20584547, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005352", "url": "https://www.ensembl.org/id/ENSBTAG00000005352" } ] } } ], "crossref": [ { "id": "F1N5Q6", "url": "https://alphafold.ebi.ac.uk/entry/F1N5Q6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005352", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005352", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IGRQWEM", "url": "https://omabrowser.org/oma/group/IGRQWEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M246", "url": "https://www.orthodb.org/?gene=A0A3Q1M246", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N5Q6", "url": "https://www.orthodb.org/?gene=F1N5Q6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11818:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11818:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M246", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M246", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M246-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M246-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5Q6", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5Q6-1", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METQTVQQELESLPTTKMAQTNPMPGSVGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVECGAWVGYEHTSFCGQQFVLERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWPNNEVGSMKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ", "length": 215, "header": "tr|F1N5Q6-1|F1N5Q6_BOVIN Isoform 1 of Crystallin beta A1 OS=Bos taurus OX=9913 GN=CRYBA1 PE=3 SV=1 CANONICAL=F1N5Q6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M246-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M246/entry", "sequence": { "sequence": "SERQSLHQKSLPTTKMAQTNPMPGSVGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVECGAWVGYEHTSFCGQQFVLERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWPNNEVGSMKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ", "length": 213, "header": "tr|A0A3Q1M246-1|F1N5Q6_BOVIN Computationally mapped isoform of Crystallin beta A1 OS=Bos taurus OX=9913 GN=CRYBA1 PE=3 SV=2 CANONICAL=F1N5Q6-1" }, "locus": { "chromosome": "19", "start_pos": 20591364, "end_pos": 20586053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078591.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078591.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064064.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064064.2" } ] } }, { "isoform_ac": "F1N5Q6-1", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6/entry", "sequence": { "sequence": "METQTVQQELESLPTTKMAQTNPMPGSVGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVECGAWVGYEHTSFCGQQFVLERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWPNNEVGSMKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ", "length": 215, "header": "tr|F1N5Q6-1|F1N5Q6_BOVIN Isoform 1 of Crystallin beta A1 OS=Bos taurus OX=9913 GN=CRYBA1 PE=3 SV=1 CANONICAL=F1N5Q6-1" }, "locus": { "chromosome": "19", "start_pos": 20591364, "end_pos": 20584551, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007037.3", "url": "https://www.ensembl.org/id/ENSBTAT00000007037.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007037.1", "url": "https://www.ensembl.org/id/ENSBTAP00000007037.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0QG53-1", "protein_name": "Crystallin beta A1", "gene_name": "CRYBA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "SETMHWQYEGSDESLPTTKMAQTNPMPGSVGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVECGAWVGYEHTSFCGQQFVLERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWFNNEVGSMKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ", "length": 217 }, "evidence": [ { "id": "F1N5Q6", "url": "https://omabrowser.org/oma/group/F1N5Q6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P05813-1", "protein_name": "Beta-crystallin A3", "gene_name": "CRYBA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ", "length": 215 }, "evidence": [ { "id": "F1N5Q6", "url": "https://omabrowser.org/oma/group/F1N5Q6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P10042-1", "protein_name": "Beta-crystallin A3", "gene_name": "CRYBA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGEAAVPPELDTFPAAKMAQTNPLPVPMGPWKITVYDQENFQGKRMEFTSACPNIMECGFDNIRSLKVECGAWVGYEHTGFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPVCSANHKESKITVYEKDNFIGRQWEISDDYPSLQAMGWANNEVGSMKIPCGAWVCYQYPGYRGYQYVLEADHHGGDYKHWREWGSHAQTSQIQSIRRIQQ", "length": 215 }, "evidence": [ { "id": "F1N5Q6", "url": "https://omabrowser.org/oma/group/F1N5Q6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P14881-1", "protein_name": "Beta-crystallin A3", "gene_name": "Cryba1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METQTVQRELETLPTTKMAQTNPMPGSMGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVECGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWFNNEVGSMKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGTHAQTSQIQSIRRIQQ", "length": 215 }, "evidence": [ { "id": "F1N5Q6", "url": "https://omabrowser.org/oma/group/F1N5Q6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of eye lens", "id": "GO:0005212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005212", "evidence": [ { "database": "UniProtKB", "id": "F1N5Q6", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "F1N5Q6", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6" } ], "pmid": "" }, { "name": "lens development in camera-type eye", "id": "GO:0002088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002088", "evidence": [ { "database": "UniProtKB", "id": "F1N5Q6", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5Q6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 215, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5Q6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5Q6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5Q6" }, { "id": "PS50915", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta/gamma crystallin 'Greek key'", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 70, "start_aa": "Trp", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 54, "end_pos": 56 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7N8-1", "uniprot_ac": "F1N7N8", "uniprot_id": "F1N7N8_BOVIN", "mass": { "chemical_mass": 115880.0, "monoisotopic_mass": 115880.0 }, "refseq": {}, "gene_names": [ { "name": "RASA1", "type": "recommended", "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ] } ], "protein_names": [ { "name": "Ras GTPase-activating protein 1", "type": "recommended", "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8/entry#names_and_taxonomy" } ] }, { "name": "Ras p21 protein activator", "type": "synonym", "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8/entry#names_and_taxonomy" } ] }, { "name": "p120GAP", "type": "synonym", "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GTPase-activating protein (GAP) that stimulates the intrinsic GTPase activity of Ras proteins, such as NRAS, facilitating their transition from the active GTP-bound state to the inactive GDP-bound state, thereby terminating Ras signaling.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M630", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M630#function" }, { "database": "UniProtKB", "id": "ARBA00094190", "url": "https://www.uniprot.org/uniprotkb/ARBA00094190#function" }, { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8#function" }, { "database": "UniProtKB", "id": "A0A3Q1MNX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNX0#function" }, { "database": "UniProtKB", "id": "A0AAA9TPY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPY9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RASA1", "url": "https://www.uniprot.org/uniprotkb/F1N7N8", "locus": { "chromosome": "7", "start_pos": 87035500, "end_pos": 86925648, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009565", "url": "https://www.ensembl.org/id/ENSBTAG00000009565" } ] } } ], "crossref": [ { "id": "F1N7N8", "url": "https://alphafold.ebi.ac.uk/entry/F1N7N8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009565", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009565", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05391", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05391", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10353", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10353", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10354", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10354", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11788", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11788", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M630", "url": "https://www.orthodb.org/?gene=A0A3Q1M630", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNX0", "url": "https://www.orthodb.org/?gene=A0A3Q1MNX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7N8", "url": "https://www.orthodb.org/?gene=F1N7N8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10194:SF146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10194:SF146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00616", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00616", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-186763", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928662", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5218921", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5218921", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8849471", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849471", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M630", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M630", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M630-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M630-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7N8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7N8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMAAEAGGEEGGPVTAGAAGGGAAAASGAYPAVCRVKIPAALPVAAAAPFPGLAEAGVAATLGGGAALGSGFLGPGSVAGTPGGVGLSAGGAAAGVAGVAAAAAGAGGEMAFAKGTTSLPTETFGAGGGFPPLPPPPPQLPTLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEAIEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTSENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDAVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLILHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILRIMESKQSCELSPSKLEKNEDVNTNLAHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLCRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR", "length": 1044, "header": "tr|F1N7N8-1|F1N7N8_BOVIN Isoform 1 of Ras GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RASA1 PE=4 SV=4 CANONICAL=F1N7N8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M630-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M630/entry", "sequence": { "sequence": "GTTGYGSVPCRLRWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTSENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDAVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLILHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILRIMESKQSCELSPSKLEKNEDVNTNLAHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLCRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR", "length": 880, "header": "tr|A0A3Q1M630-1|F1N7N8_BOVIN Computationally mapped isoform of Ras GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RASA1 PE=4 SV=2 CANONICAL=F1N7N8-1" }, "locus": { "chromosome": "7", "start_pos": 87034754, "end_pos": 86927066, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076668.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076668.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065397.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065397.2" } ] } }, { "isoform_ac": "A0A3Q1MNX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNX0/entry", "sequence": { "sequence": "MMAAEAGGEEGGPVTAGAAGGGAAAASGAYPAVCRVKIPAALPVAAAAPFPGLAEAGVAATLGGGAALGSGFLGPGSVAGTPGGVGLSAGGAAAGVAGVAAAAAGAGGEMAFAKGTTSLPTETFGAGGGFPPLPPPPPQLPTLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVVKAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTSENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDAVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLILHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILRIMESKQSCELSPSKLEKNEDVNTNLAHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLCRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR", "length": 1025, "header": "tr|A0A3Q1MNX0-1|F1N7N8_BOVIN Computationally mapped isoform of Ras GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RASA1 PE=4 SV=2 CANONICAL=F1N7N8-1" }, "locus": { "chromosome": "7", "start_pos": 87034754, "end_pos": 86926247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073443.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073443.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073013.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073013.2" } ] } }, { "isoform_ac": "A0AAA9TPY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPY9/entry", "sequence": { "sequence": "MMAAEAGGEEGGPVTAGAAGGGAAAASGAYPAVCRVKIPAALPVAAAAPFPGLAEAGVAATLGGGAALGSGFLGPGSVAGTPGGVGLSAGGAAAGVAGVAAAAAGAGGEMAFAKGTTSLPTETFGAGGGFPPLPPPPPQLPTLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEAIEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTSENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDAVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLILHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELSPSKLEKNEDVNTNLAHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLCRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR", "length": 943, "header": "tr|A0AAA9TPY9-1|F1N7N8_BOVIN Computationally mapped isoform of Ras GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RASA1 PE=4 SV=1 CANONICAL=F1N7N8-1" }, "locus": { "chromosome": "7", "start_pos": 87034754, "end_pos": 86926247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099236.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099236.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099353.1" } ] } }, { "isoform_ac": "F1N7N8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7N8/entry", "sequence": { "sequence": "MMAAEAGGEEGGPVTAGAAGGGAAAASGAYPAVCRVKIPAALPVAAAAPFPGLAEAGVAATLGGGAALGSGFLGPGSVAGTPGGVGLSAGGAAAGVAGVAAAAAGAGGEMAFAKGTTSLPTETFGAGGGFPPLPPPPPQLPTLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEAIEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTSENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDAVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLILHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILRIMESKQSCELSPSKLEKNEDVNTNLAHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLCRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR", "length": 1044, "header": "tr|F1N7N8-1|F1N7N8_BOVIN Isoform 1 of Ras GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RASA1 PE=4 SV=4 CANONICAL=F1N7N8-1" }, "locus": { "chromosome": "7", "start_pos": 87034754, "end_pos": 86926247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012583.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012583.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012583.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012583.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 81, "start_aa": "Thr", "end_pos": 81, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr81", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-186763", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "resource": "Reactome", "description": "Downstream signal transduction" }, { "id": "R-BTA-3928662", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "resource": "Reactome", "description": "EPHB-mediated forward signaling" }, { "id": "R-BTA-5218921", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5218921", "resource": "Reactome", "description": "VEGFR2 mediated cell proliferation" }, { "id": "R-BTA-8849471", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849471", "resource": "Reactome", "description": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "system development", "id": "GO:0048731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048731", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "negative regulation of cell-matrix adhesion", "id": "GO:0001953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001953", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "regulation of intracellular signal transduction", "id": "GO:1902531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902531", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "regulation of actin filament polymerization", "id": "GO:0030833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030833", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "GTPase binding", "id": "GO:0051020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051020", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "F1N7N8", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 657, "end_pos": 659, "annotation": "n_glycosylation_sequon" }, { "start_pos": 885, "end_pos": 887, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7N8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1044, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7N8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7N8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 574, "end_pos": 687, "start_aa": "Asn", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 471, "end_pos": 574, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" }, { "id": "PS50018", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50018" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-GAP", "eco_id": "ECO_0000259", "start_pos": 745, "end_pos": 939, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 178, "end_pos": 269, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7N8" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 276, "end_pos": 338, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 81 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 657, "end_pos": 659 }, { "start_pos": 885, "end_pos": 887 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q334-1", "uniprot_ac": "F6Q334", "uniprot_id": "F6Q334_BOVIN", "mass": { "chemical_mass": 55676.0, "monoisotopic_mass": 55676.0 }, "refseq": {}, "gene_names": [ { "name": "NAPA", "type": "recommended", "evidence": [ { "id": "F6Q334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ] } ], "protein_names": [ { "name": "NSF attachment protein alpha", "type": "synonym", "evidence": [ { "id": "F6Q334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q334/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M6H3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H3#function" }, { "database": "UniProtKB", "id": "RU367013", "url": "https://www.uniprot.org/uniprotkb/RU367013#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAPA", "url": "https://www.uniprot.org/uniprotkb/F6Q334", "locus": { "chromosome": "18", "start_pos": 54461037, "end_pos": 54487597, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013084", "url": "https://www.ensembl.org/id/ENSBTAG00000013084" } ] } } ], "crossref": [ { "id": "F6Q334", "url": "https://alphafold.ebi.ac.uk/entry/F6Q334", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013084", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013084", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15832", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15832", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000744", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000744", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M6H3", "url": "https://www.orthodb.org/?gene=A0A3Q1M6H3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6Q334", "url": "https://www.orthodb.org/?gene=F6Q334", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13768", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13768", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13768:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13768:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M6H3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6H3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q334-1", "url": "https://www.uniprot.org/uniprotkb/F6Q334-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNSGKEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGSAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEETCAKPRRAPAPVSLPRPLSPGQALQRGSPCEPRERGARDPGCEPFPPPTEDSTATPRAQHCFRGPRGRAHWPDGHPLFSLHPSPPALYLSPQSCSSPPRHTGSLAGSLAQACSLWVLPGVGVRIQPHLSQPAESWSRCLVSSSPPSSLAELWVHVATVIRSHCWGGSGSFPPPRTGSPLPPAAPTSQDGPSPGAARVVPMPTPPSPPCASRWWWWEAAATRGRK", "length": 507, "header": "tr|F6Q334-1|F6Q334_BOVIN Isoform 1 of NSF attachment protein alpha OS=Bos taurus OX=9913 GN=NAPA PE=3 SV=2 CANONICAL=F6Q334-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6H3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H3/entry", "sequence": { "sequence": "MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGSAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEETCAKSHRLWGS", "length": 303, "header": "tr|A0A3Q1M6H3-1|F6Q334_BOVIN Computationally mapped isoform of NSF attachment protein alpha OS=Bos taurus OX=9913 GN=NAPA PE=3 SV=2 CANONICAL=F6Q334-1" }, "locus": { "chromosome": "18", "start_pos": 54487299, "end_pos": 54461040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069659.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069659.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069334.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069334.2" } ] } }, { "isoform_ac": "A0AAA9SDN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDN2/entry", "sequence": { "sequence": "MGEQPRLLPWKQKGGDFPNTVGSSKIEEACEIYARAANMFKMAKNWSAAGSAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEETCAKPRRAPAPVSLPRPLSPGQALQRGSPCEPRERGARDPGCEPFPPPTEDSTATPRAQHCFRGPRGRAHWPDGHPLFSLHPSPPALYLSPQSCSSPPRHTGSLAGSLAQACSLWVLPGVGVRIQPHLSQPAESWSRCLVSSSPPSSLAELWVHVATVIRSHCWGGSGSFPPPRTGSPLPPAAPTSQDGPSPGAARVVPMPTPPSPPCASRWWWWEAAATRGRK", "length": 504, "header": "tr|A0AAA9SDN2-1|F6Q334_BOVIN Computationally mapped isoform of NSF attachment protein alpha OS=Bos taurus OX=9913 GN=NAPA PE=3 SV=1 CANONICAL=F6Q334-1" }, "locus": { "chromosome": "18", "start_pos": 54483248, "end_pos": 54461504, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098350.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098350.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081927.1" } ] } }, { "isoform_ac": "F6Q334-1", "url": "https://www.uniprot.org/uniprotkb/F6Q334/entry", "sequence": { "sequence": "MDNSGKEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGSAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAAQLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWLTTMLLRIKKTIQGDEETCAKPRRAPAPVSLPRPLSPGQALQRGSPCEPRERGARDPGCEPFPPPTEDSTATPRAQHCFRGPRGRAHWPDGHPLFSLHPSPPALYLSPQSCSSPPRHTGSLAGSLAQACSLWVLPGVGVRIQPHLSQPAESWSRCLVSSSPPSSLAELWVHVATVIRSHCWGGSGSFPPPRTGSPLPPAAPTSQDGPSPGAARVVPMPTPPSPPCASRWWWWEAAATRGRK", "length": 507, "header": "tr|F6Q334-1|F6Q334_BOVIN Isoform 1 of NSF attachment protein alpha OS=Bos taurus OX=9913 GN=NAPA PE=3 SV=2 CANONICAL=F6Q334-1" }, "locus": { "chromosome": "18", "start_pos": 54487299, "end_pos": 54461504, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017397.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017397.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017397.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017397.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 485, "start_aa": "Thr", "end_pos": 485, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr485", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811434", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" }, { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "SNARE complex disassembly", "id": "GO:0035494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035494", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "synaptic transmission, glutamatergic", "id": "GO:0035249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035249", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle priming", "id": "GO:0010807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010807", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "terminal bouton", "id": "GO:0043195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043195", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "synaptobrevin 2-SNAP-25-syntaxin-1a complex", "id": "GO:0070044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070044", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" }, { "name": "soluble NSF attachment protein activity", "id": "GO:0005483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005483", "evidence": [ { "database": "UniProtKB", "id": "F6Q334", "url": "https://www.uniprot.org/uniprotkb/F6Q334" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6Q334-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 507, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6Q334-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6Q334" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 485 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N628-1", "uniprot_ac": "F1N628", "uniprot_id": "F1N628_BOVIN", "mass": { "chemical_mass": 130662.0, "monoisotopic_mass": 130662.0 }, "refseq": { "ac": "XP_005204997", "name": "zinc finger and SCAN domain-containing protein 20 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204997" }, "gene_names": [ { "name": "ZSCAN20", "type": "recommended", "evidence": [ { "id": "F1N628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ] }, { "name": "ZSCAN20", "type": "synonym", "evidence": [ { "id": "XP_005204997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204997" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain-containing protein 20", "type": "recommended", "evidence": [ { "id": "F1N628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N628/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 31", "type": "synonym", "evidence": [ { "id": "F1N628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N628/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and SCAN domain-containing protein 20 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204997" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M9N3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N3#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSCAN20", "url": "https://www.uniprot.org/uniprotkb/F1N628", "locus": { "chromosome": "3", "start_pos": 112321229, "end_pos": 112338396, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019555", "url": "https://www.ensembl.org/id/ENSBTAG00000019555" } ] } } ], "crossref": [ { "id": "F1N628", "url": "https://alphafold.ebi.ac.uk/entry/F1N628", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019555", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019555", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538651", "url": "https://www.ncbi.nlm.nih.gov/gene/538651", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N628", "url": "https://www.orthodb.org/?gene=F1N628", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13837", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13837", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204997", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204997", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9N3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9N3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N628-1", "url": "https://www.uniprot.org/uniprotkb/F1N628-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNNLFRFVPVPEEMVHLLADYTCKTASEEGAGPHSGARAVPSGSCSHRSAIHGVALFGLRVPAFPARVLEHFRPVVKWVSWWSRGGLSSPESPLRTHYRCRKTLDMESPAEGRRPGEKMAVALEARASPQQEPEELVIVKLEEDSWTPVSQPKKDRDHVPGPEASRQRFRQFQYREAAGPHEAFSQLWALCCHWLRPEIRLKEQILELLVLEQFLTILPQEAQAWVQARHPESGEEAVALVEDWHREARAAGQRELELCAEDTRSLKTTKESQGCQLQPADHWPEEQSQKQWVKNSCPDLPKNLDTKMVPQPLKESAVLTPRVPALPKTGSVGDWEVTAESQEALGPDRHAEKEFCTDPPGDNCGNGLSLGVPVSKPTIIAQQEQGPEFWGPRLVNSGKKNSADYSVDPEQTKPAQALAWRDCKTWEERCPAPVEDVKVSGVHWSYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAERLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRASDGPGETVALPRLGDSDMEVDEQEEGGWEPEETADDCNGDDVATESIQGPGIPGGPALLQSRIAGVHWGYEETKAFLTILSESPFSEKLRTCHQNSQVYRAIAERLCAQGFLRTLEQCRYRFKNLLRSYRKAKSSHPPGTCPFYEELDSLMRARTAVRDMGTGGEAAGLPTSDQSSTEVVSQEAWDEMAGEDVIRPPTPSPKTSDTGFEMRCEDEDQIPEDDLFCNLPRALSKCTAGDDCYPHDSGEDSENENEGKGQWGDPSQEQWEECSSEEDLEKLIDHQGLYLAEKPYKCDMCVKTFSRNSQLTTHQRIHTGEKPYKCLECGKSFSDRSNFNTHQRIHTGEKPYECLECGKSFSDLSNLITHQRTHMKVKPYKCEECWESFIQSSDLLKHQGIHLGGNSDHCREPGENSGQSPSFSAHWRNSTEGTNPEQPHSASKNANSPGPQSTHAGEKLYQCSECGRSFSKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYECMDCGKCFGERSKLITHQRVHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKPYKCTECGKDFNNSSHFSAHRRTHAGGKAS", "length": 1161, "header": "tr|F1N628-1|F1N628_BOVIN Isoform 1 of Zinc finger and SCAN domain-containing protein 20 OS=Bos taurus OX=9913 GN=ZSCAN20 PE=3 SV=3 CANONICAL=F1N628-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9N3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N3/entry", "sequence": { "sequence": "MESPAEGRRPGEKMAVALEARASPQQEPEELVIVKLEEDSWTPVSQPKKDRDHVPGPEASRQRFRQFQYREAAGPHEAFSQLWALCCHWLRPEIRLKEQILELLVLEQFLTILPQEAQAWVQARHPESGEEAVALVEDWHREARAAGQRELELCAEDTRSLKTTKESQGCQLQPADHWPEEQSQKQWVKNSCPDLPKNLDTKMVPQPLKESGVPVSKPTIIAQQEQGPEFWGPRLVNSGKKNSADYSVDPEQTKPAQALAWRDCKTWEERCPAPVEDVKVSGVHWSYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAERLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRASDGPGETVALPRLGDSDMEVDEQEEGGWEPEETADDCNGDDVATESIQGPGIPGGPALLQSRIGKNFGA", "length": 445, "header": "tr|A0A3Q1M9N3-1|F1N628_BOVIN Computationally mapped isoform of Zinc finger and SCAN domain-containing protein 20 OS=Bos taurus OX=9913 GN=ZSCAN20 PE=3 SV=1 CANONICAL=F1N628-1" }, "locus": { "chromosome": "3", "start_pos": 112333028, "end_pos": 112326925, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078171.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078171.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066885.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066885.2" } ] } }, { "isoform_ac": "F1N628-1", "url": "https://www.uniprot.org/uniprotkb/F1N628/entry", "sequence": { "sequence": "MRNNLFRFVPVPEEMVHLLADYTCKTASEEGAGPHSGARAVPSGSCSHRSAIHGVALFGLRVPAFPARVLEHFRPVVKWVSWWSRGGLSSPESPLRTHYRCRKTLDMESPAEGRRPGEKMAVALEARASPQQEPEELVIVKLEEDSWTPVSQPKKDRDHVPGPEASRQRFRQFQYREAAGPHEAFSQLWALCCHWLRPEIRLKEQILELLVLEQFLTILPQEAQAWVQARHPESGEEAVALVEDWHREARAAGQRELELCAEDTRSLKTTKESQGCQLQPADHWPEEQSQKQWVKNSCPDLPKNLDTKMVPQPLKESAVLTPRVPALPKTGSVGDWEVTAESQEALGPDRHAEKEFCTDPPGDNCGNGLSLGVPVSKPTIIAQQEQGPEFWGPRLVNSGKKNSADYSVDPEQTKPAQALAWRDCKTWEERCPAPVEDVKVSGVHWSYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAERLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRASDGPGETVALPRLGDSDMEVDEQEEGGWEPEETADDCNGDDVATESIQGPGIPGGPALLQSRIAGVHWGYEETKAFLTILSESPFSEKLRTCHQNSQVYRAIAERLCAQGFLRTLEQCRYRFKNLLRSYRKAKSSHPPGTCPFYEELDSLMRARTAVRDMGTGGEAAGLPTSDQSSTEVVSQEAWDEMAGEDVIRPPTPSPKTSDTGFEMRCEDEDQIPEDDLFCNLPRALSKCTAGDDCYPHDSGEDSENENEGKGQWGDPSQEQWEECSSEEDLEKLIDHQGLYLAEKPYKCDMCVKTFSRNSQLTTHQRIHTGEKPYKCLECGKSFSDRSNFNTHQRIHTGEKPYECLECGKSFSDLSNLITHQRTHMKVKPYKCEECWESFIQSSDLLKHQGIHLGGNSDHCREPGENSGQSPSFSAHWRNSTEGTNPEQPHSASKNANSPGPQSTHAGEKLYQCSECGRSFSKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYECMDCGKCFGERSKLITHQRVHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKPYKCTECGKDFNNSSHFSAHRRTHAGGKAS", "length": 1161, "header": "tr|F1N628-1|F1N628_BOVIN Isoform 1 of Zinc finger and SCAN domain-containing protein 20 OS=Bos taurus OX=9913 GN=ZSCAN20 PE=3 SV=3 CANONICAL=F1N628-1" }, "locus": { "chromosome": "3", "start_pos": 112338295, "end_pos": 112322233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026057.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026057.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026057.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026057.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N628", "url": "https://www.uniprot.org/uniprotkb/F1N628" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1115, "end_pos": 1117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1143, "end_pos": 1145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1144, "end_pos": 1146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 961, "end_pos": 963, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N628-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1161, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N628-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N628" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N628" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 828, "end_pos": 855, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N628" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 167, "end_pos": 248, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1115, "end_pos": 1117 }, { "start_pos": 1143, "end_pos": 1145 }, { "start_pos": 1144, "end_pos": 1146 }, { "start_pos": 961, "end_pos": 963 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6PZE4-1", "uniprot_ac": "F6PZE4", "uniprot_id": "F6PZE4_BOVIN", "mass": { "chemical_mass": 91296.0, "monoisotopic_mass": 91296.0 }, "refseq": {}, "gene_names": [ { "name": "NOX5", "type": "recommended", "evidence": [ { "id": "F6PZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ] } ], "protein_names": [ { "name": "NADPH oxidase 5", "type": "synonym", "evidence": [ { "id": "F6PZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZE4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOX5", "url": "https://www.uniprot.org/uniprotkb/F6PZE4", "locus": { "chromosome": "10", "start_pos": 15888853, "end_pos": 15849435, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009030", "url": "https://www.ensembl.org/id/ENSBTAG00000009030" } ] } } ], "crossref": [ { "id": "F6PZE4", "url": "https://alphafold.ebi.ac.uk/entry/F6PZE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009030", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009030", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06186", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06186", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFE9", "url": "https://www.orthodb.org/?gene=A0A3Q1MFE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6PZE4", "url": "https://www.orthodb.org/?gene=F6PZE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11972:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11972:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13405", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13405", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3299685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MFE9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZE4-1", "url": "https://www.uniprot.org/uniprotkb/F6PZE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAPGDTAWTDSEGFRGTMNAEEDAKWLQWVTHQFKTIAGEDGEINLQDFKKALKVKESFFAERFFVLFDSDGSGTITLQELQKALTLLIHGSPMDKLKFLFQVYDVDGSGSIDADELRTVLQSCLYESAISLPKEKLDQLTLALFESADKDCSGTITFEELRDELQRFPGVLENLTISAAHWLTPPAPQRHRRQPRLLTSAYWHNHRSHVLCLAVFVGLHMLLFALAASAYRAFGSSVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDHNIQFHQLMGYVVVGLSLVHTVAHVVNFALQAQSETSPFRFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFACSSSCVRRSGHFEVFYWTHLSYLPMWLLLILHGPNFWKWLLVPGTLFFLEKTISLAASRMAALHIVEVNLLPSKVTHLLIKRPPLFHYRPGDYLYLNIPSIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLFESFKKPEPVFCGSKRLSRRLEMKRSQRKPQQGLQPQPIDFGASAQGAVASNKEGIVELISYRPEGAPWQGHEGLVNTGTKDRTRAQREAAAEDPALVSEMSSENHQFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSILYRHQKRKHICPNCQHSWMESGQDEDMKLHKVDFIWINRDQQSFEWFVSLLTKLEMDQAEETQEGRFLELHMYMTSALSKNDIKAIGLQMALDLLAKKEKKDSITGLQTRTQPGRPDWNKVFQKVAAEKKGKVQVFFCGSPALAKILKGHCEQFSFKFFQENF", "length": 804, "header": "tr|F6PZE4-1|F6PZE4_BOVIN Isoform 1 of NADPH oxidase 5 OS=Bos taurus OX=9913 GN=NOX5 PE=4 SV=2 CANONICAL=F6PZE4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFE9/entry", "sequence": { "sequence": "MNAEEDAKWLQWVTHQFKTIAGEDGEINLQDFKKALKVKESFFAERFFVLFDSDGSGTITLQELQKALTLLIHGSPMDKLKFLFQVYDVDGSGSIDADELRTVLQSCLYESAISLPKEKLDQLTLALFESADKDCSGTITFEELRDELQRFPGVLENLTISAAHWLTPPAPQRHRRQPRLLTSAYWHNHRSHVLCLAVFVGLHMLLFALAASAYRAFGSSVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDHNIQFHQLMGYVVVGLSLVHTVAHVVNFALQAQSETSPFRFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFACSSSCVRRSGHFEVFYWTHLSYLPMWLLLILHGPNFWKWLLVPGTLFFLEKTISLAASRMAALHIVEVNLLPSKVTHLLIKRPPLFHYRPGDYLYLNIPSIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLFESFKKPEPVFCGSKRLSRRLEMKRSQRKPQGLQPQPIDFGASAQGAVASNKEGIVELISYRPEGAPWQGHEGLVNTGTKDRTRAQREAAAEDPALVSEMSSENHQFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSILYRHQKRKHICPNCQHSWMESGQDEDMKLHKVDFIWINRDQQSFEWFVSLLTKLEMDQAEETQEGRFLELHMYMTSALSKNDIKAIGLQMALDLLAKKEKKDSITGLQTRTQPGRPDWNKVFQKVAAEKKGKVQVFFCGSPALAKILKGHCEQFSFKFFQENF", "length": 785, "header": "tr|A0A3Q1MFE9-1|F6PZE4_BOVIN Computationally mapped isoform of NADPH oxidase 5 OS=Bos taurus OX=9913 GN=NOX5 PE=4 SV=3 CANONICAL=F6PZE4-1" }, "locus": { "chromosome": "10", "start_pos": 15888223, "end_pos": 15856222, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068426.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068426.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069253.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069253.3" } ] } }, { "isoform_ac": "F6PZE4-1", "url": "https://www.uniprot.org/uniprotkb/F6PZE4/entry", "sequence": { "sequence": "MSAPGDTAWTDSEGFRGTMNAEEDAKWLQWVTHQFKTIAGEDGEINLQDFKKALKVKESFFAERFFVLFDSDGSGTITLQELQKALTLLIHGSPMDKLKFLFQVYDVDGSGSIDADELRTVLQSCLYESAISLPKEKLDQLTLALFESADKDCSGTITFEELRDELQRFPGVLENLTISAAHWLTPPAPQRHRRQPRLLTSAYWHNHRSHVLCLAVFVGLHMLLFALAASAYRAFGSSVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDHNIQFHQLMGYVVVGLSLVHTVAHVVNFALQAQSETSPFRFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFACSSSCVRRSGHFEVFYWTHLSYLPMWLLLILHGPNFWKWLLVPGTLFFLEKTISLAASRMAALHIVEVNLLPSKVTHLLIKRPPLFHYRPGDYLYLNIPSIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLFESFKKPEPVFCGSKRLSRRLEMKRSQRKPQQGLQPQPIDFGASAQGAVASNKEGIVELISYRPEGAPWQGHEGLVNTGTKDRTRAQREAAAEDPALVSEMSSENHQFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSILYRHQKRKHICPNCQHSWMESGQDEDMKLHKVDFIWINRDQQSFEWFVSLLTKLEMDQAEETQEGRFLELHMYMTSALSKNDIKAIGLQMALDLLAKKEKKDSITGLQTRTQPGRPDWNKVFQKVAAEKKGKVQVFFCGSPALAKILKGHCEQFSFKFFQENF", "length": 804, "header": "tr|F6PZE4-1|F6PZE4_BOVIN Isoform 1 of NADPH oxidase 5 OS=Bos taurus OX=9913 GN=NOX5 PE=4 SV=2 CANONICAL=F6PZE4-1" }, "locus": { "chromosome": "10", "start_pos": 15888223, "end_pos": 15849508, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011888.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011888.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011888.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011888.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3299685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "resource": "Reactome", "description": "Detoxification of Reactive Oxygen Species" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "NADPH oxidase complex", "id": "GO:0043020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "proton channel activity", "id": "GO:0015252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015252", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "superoxide-generating NAD(P)H oxidase activity", "id": "GO:0016175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016175", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "superoxide-generating NADPH oxidase activity", "id": "GO:0106292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106292", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "endothelial cell proliferation", "id": "GO:0001935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001935", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" }, { "name": "superoxide anion generation", "id": "GO:0042554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554", "evidence": [ { "database": "UniProtKB", "id": "F6PZE4", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6PZE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 804, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6PZE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6PZE4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6PZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 92, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F6PZE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZE4" }, { "id": "PS51384", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51384" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD-binding FR-type", "eco_id": "ECO_0000259", "start_pos": 413, "end_pos": 527, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 175, "end_pos": 177 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5K1-1", "uniprot_ac": "F1N5K1", "uniprot_id": "F1N5K1_BOVIN", "mass": { "chemical_mass": 94381.0, "monoisotopic_mass": 94381.0 }, "refseq": { "ac": "XP_059731238", "name": "cyclin-dependent kinase 11B isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238" }, "gene_names": [ { "name": "CDK11B", "type": "recommended", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "name": "CDC2L1", "type": "synonym", "evidence": [ { "id": "XP_059731238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238" } ] }, { "name": "CDC2L2", "type": "synonym", "evidence": [ { "id": "XP_059731238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238" } ] }, { "name": "CDK11B", "type": "synonym", "evidence": [ { "id": "XP_059731238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238" } ] }, { "name": "CDK11", "type": "synonym", "evidence": [ { "id": "XP_059731238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238" } ] } ], "protein_names": [ { "name": "Galactosyltransferase-associated protein kinase p58/GTA", "type": "recommended", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.22", "type": "synonym", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.23", "type": "synonym", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1/entry#names_and_taxonomy" } ] }, { "name": "cyclin-dependent kinase 11B isoform X3", "type": "synonym", "evidence": [ { "id": "XP_059731238", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5K1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDK11B", "url": "https://www.uniprot.org/uniprotkb/F1N5K1", "locus": {} } ], "crossref": [ { "id": "F1N5K1", "url": "https://alphafold.ebi.ac.uk/entry/F1N5K1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010737", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010737", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07843", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07843", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "493708", "url": "https://www.ncbi.nlm.nih.gov/gene/493708", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5K1", "url": "https://www.orthodb.org/?gene=F1N5K1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24056", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24056", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24056:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24056:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059731238", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731238", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10216", "url": "https://www.rhea-db.org/rhea/10216", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MGN2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5K1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5K1-1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPPSNGPVAHAAQVVFQINSDGENSSRVLTQMGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRRELAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTVREDYSDKVKASHWSRSPLRPPRERLEPGDSRKPVKEEKVEERDLLSDLQDVSDSERKTSSAESSSAESGSGSEEEEEEEEEEEGSSSEESEEEEEEEEEEEEEETGSNSEDVSGQSAEEVSEEEMSEDEERENENHVLVVPESRFDHDSGESEEGEEEAGEGTPQSSALTEGDFVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYNDLPAVKKMTFTEYPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRVNAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF", "length": 814, "header": "tr|F1N5K1-1|F1N5K1_BOVIN Isoform 1 of Galactosyltransferase-associated protein kinase p58/GTA OS=Bos taurus OX=9913 GN=CDK11B PE=3 SV=3 CANONICAL=F1N5K1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGN2/entry", "sequence": { "sequence": "MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRRELAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTVREDYSDKVKASHWSRSPLRPPRERLEPGDSRKPVKEEKVEERDLLSDLQDVSDSERKTSSAESSSGDCSPGPAQLSHHRAGPKFTAACFLPKAESGSGSEEEEEEEEEEEGSSSEESEEEEEEEEEEEEEETGSNSEDVSGQSAEEVSEEEMSEDEERENENHVLVVPESRFDHDSGESEEGEEEAGEGTPQSSALTEGDFVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYNDLPAVKKMTFTEYPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRVNAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF", "length": 774, "header": "tr|A0A3Q1MGN2-1|F1N5K1_BOVIN Computationally mapped isoform of Galactosyltransferase-associated protein kinase p58/GTA OS=Bos taurus OX=9913 GN=CDK11B PE=3 SV=2 CANONICAL=F1N5K1-1" }, "locus": { "chromosome": "16", "start_pos": 51002927, "end_pos": 50986341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080107.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080107.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068184.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068184.2" } ] } }, { "isoform_ac": "F1N5K1-1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1/entry", "sequence": { "sequence": "MGLPPSNGPVAHAAQVVFQINSDGENSSRVLTQMGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRRELAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTVREDYSDKVKASHWSRSPLRPPRERLEPGDSRKPVKEEKVEERDLLSDLQDVSDSERKTSSAESSSAESGSGSEEEEEEEEEEEGSSSEESEEEEEEEEEEEEEETGSNSEDVSGQSAEEVSEEEMSEDEERENENHVLVVPESRFDHDSGESEEGEEEAGEGTPQSSALTEGDFVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYNDLPAVKKMTFTEYPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRVNAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF", "length": 814, "header": "tr|F1N5K1-1|F1N5K1_BOVIN Isoform 1 of Galactosyltransferase-associated protein kinase p58/GTA OS=Bos taurus OX=9913 GN=CDK11B PE=3 SV=3 CANONICAL=F1N5K1-1" }, "locus": { "chromosome": "16", "start_pos": 51002927, "end_pos": 50983987, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014227.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014227.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014227.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014227.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N5K1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0004693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", "evidence": [ { "database": "UniProtKB", "id": "F1N5K1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1N5K1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N5K1", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10216", "name": "", "equation": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E518-1", "P48734-1", "A0A3Q1LNU2-1", "E1BB50-1", "E1BB52-1", "Q5EAB2-1", "F1MPI8-1", "A0AAF6YMX3-1", "F1N5K1-1" ], "evidence": [ { "id": "10216", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10216" } ] }, { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-380311", "name": "Recruitment of Plk1 to centrosomes", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00517-1", "A0A3Q1MS69-1", "P35508-1", "P48734-1", "P81948-1", "Q2TA25-1", "F1N5K1-1", "A2VDZ4-1", "Q76LV2-1" ], "evidence": [ { "id": "R-BTA-380311", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380311" } ] }, { "id": "R-BTA-380455", "name": "Recruitment of CDK11p58 to the centrosomes", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00517-1", "A0A3Q1MS69-1", "P35508-1", "P48734-1", "P81948-1", "Q2TA25-1", "F1N5K1-1", "A2VDZ4-1", "Q76LV2-1" ], "evidence": [ { "id": "R-BTA-380455", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380455" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5K1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 814, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5K1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5K1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 457, "end_pos": 742, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.22", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22" }, { "id": "2.7.11.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.22" } ] }, { "ec_number": "2.7.11.23", "ec_name": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "2.7.11.23", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23" }, { "id": "2.7.11.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.23" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 26, "end_pos": 28 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N579-1", "uniprot_ac": "F1N579", "uniprot_id": "F1N579_BOVIN", "mass": { "chemical_mass": 60292.0, "monoisotopic_mass": 60292.0 }, "refseq": { "ac": "XP_005219737", "name": "epsin-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219737" }, "gene_names": [ { "name": "EPN1", "type": "recommended", "evidence": [ { "id": "F1N579", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ] }, { "name": "EPN1", "type": "synonym", "evidence": [ { "id": "XP_005219737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219737" } ] } ], "protein_names": [ { "name": "Epsin 1", "type": "synonym", "evidence": [ { "id": "F1N579", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N579/entry#names_and_taxonomy" } ] }, { "name": "epsin-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005219737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219737" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPN1", "url": "https://www.uniprot.org/uniprotkb/F1N579", "locus": { "chromosome": "18", "start_pos": 61867751, "end_pos": 61875826, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046996", "url": "https://www.ensembl.org/id/ENSBTAG00000046996" } ] } } ], "crossref": [ { "id": "F1N579", "url": "https://alphafold.ebi.ac.uk/entry/F1N579", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046996", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046996", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16990", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16990", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508199", "url": "https://www.ncbi.nlm.nih.gov/gene/508199", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MI34", "url": "https://www.orthodb.org/?gene=A0A3Q1MI34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N579", "url": "https://www.orthodb.org/?gene=F1N579", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12276", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12276", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12276:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12276:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01417", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01417", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-182971", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005219737", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219737", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI34", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N579-1", "url": "https://www.uniprot.org/uniprotkb/F1N579-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTSSLRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKARQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQVPPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETAGQEESSLMDLADVFTAPAAAPATDPWGAPVSMAAALPTAAPASDPWGGPPVPQAADPWGGPAPTPASGDPWRPAAPAGPPADPWGGTQAPAAGEGPAPDPWGGSDGGAPVSGPPASDPWAPAPAFSDPWGGSPAKPSTNGTAVVGGFDTEADEFSDFDRLRTALPASGSSTGELELLAGEVPARSPGAFDMSGVGGSLAEAVGSPPPAAAPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPAMPGAKASNPFLPSGAPATGPSITNPFQPAPPATLTLNQLRISPVPPVAGAPSTYISPLGGGPGLPPMMPPGPPAPNTNPFLL", "length": 578, "header": "tr|F1N579-1|F1N579_BOVIN Isoform 1 of Epsin 1 OS=Bos taurus OX=9913 GN=EPN1 PE=3 SV=2 CANONICAL=F1N579-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MI34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI34/entry", "sequence": { "sequence": "MSTSSLRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKARQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESKRETAGQEESSLMDLADVFTAPAAAPATDPWGAPVSMAAALPTAAPASDPWGGPPVPQAADPWGGPAPTPASGDPWRPAAPAGPPADPWGGTQAPAAGEGPAPDPWGGSDGGAPVSGPPASDPWAPAPAFSDPWGGSPAKPSTNGTAVVGGFDTEADEFSDFDRLRTALPASGSSTGELELLAGEVPARSPGAFDMSGVGGSLAEAVGSPPPAAAPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPAMPGAKASNPFLPSGAPATGPSITNPFQPAPPATLTLNQLRISPVPPVAGAPSTYISPLGGGPGLPPMMPPGPPAPNTNPFLL", "length": 551, "header": "tr|A0A3Q1MI34-1|F1N579_BOVIN Computationally mapped isoform of Epsin 1 OS=Bos taurus OX=9913 GN=EPN1 PE=3 SV=1 CANONICAL=F1N579-1" }, "locus": { "chromosome": "18", "start_pos": 61875820, "end_pos": 61868146, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075559.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075559.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068782.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068782.1" } ] } }, { "isoform_ac": "F1N579-1", "url": "https://www.uniprot.org/uniprotkb/F1N579/entry", "sequence": { "sequence": "MSTSSLRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKARQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQVPPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETAGQEESSLMDLADVFTAPAAAPATDPWGAPVSMAAALPTAAPASDPWGGPPVPQAADPWGGPAPTPASGDPWRPAAPAGPPADPWGGTQAPAAGEGPAPDPWGGSDGGAPVSGPPASDPWAPAPAFSDPWGGSPAKPSTNGTAVVGGFDTEADEFSDFDRLRTALPASGSSTGELELLAGEVPARSPGAFDMSGVGGSLAEAVGSPPPAAAPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPAMPGAKASNPFLPSGAPATGPSITNPFQPAPPATLTLNQLRISPVPPVAGAPSTYISPLGGGPGLPPMMPPGPPAPNTNPFLL", "length": 578, "header": "tr|F1N579-1|F1N579_BOVIN Isoform 1 of Epsin 1 OS=Bos taurus OX=9913 GN=EPN1 PE=3 SV=2 CANONICAL=F1N579-1" }, "locus": { "chromosome": "18", "start_pos": 61875820, "end_pos": 61868146, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064026.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064026.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055682.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055682.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 316, "start_aa": "Thr", "end_pos": 316, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr316", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 464, "start_aa": "Thr", "end_pos": 464, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr464", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 466, "start_aa": "Thr", "end_pos": 466, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr466", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-182971", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-182971", "resource": "Reactome", "description": "EGFR downregulation" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "clathrin vesicle coat", "id": "GO:0030125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030125", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "molecular sequestering activity", "id": "GO:0140313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140313", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" }, { "name": "negative regulation of sprouting angiogenesis", "id": "GO:1903671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903671", "evidence": [ { "database": "UniProtKB", "id": "F1N579", "url": "https://www.uniprot.org/uniprotkb/F1N579" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N579-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 578, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N579-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N579" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N579", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N579" }, { "id": "PS50942", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50942" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ENTH", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 144, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 316, 464, 466 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 391, "end_pos": 393 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N331-1", "uniprot_ac": "F1N331", "uniprot_id": "F1N331_BOVIN", "mass": { "chemical_mass": 82647.0, "monoisotopic_mass": 82647.0 }, "refseq": { "ac": "XP_005209752", "name": "hyaluronan mediated motility receptor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209752" }, "gene_names": [ { "name": "HMMR", "type": "recommended", "evidence": [ { "id": "F1N331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ] }, { "name": "HMMR", "type": "synonym", "evidence": [ { "id": "XP_005209752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209752" } ] }, { "name": "rhamm", "type": "synonym", "evidence": [ { "id": "XP_005209752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209752" } ] } ], "protein_names": [ { "name": "Hyaluronan mediated motility receptor", "type": "synonym", "evidence": [ { "id": "F1N331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N331/entry#names_and_taxonomy" } ] }, { "name": "hyaluronan mediated motility receptor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209752" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HMMR", "url": "https://www.uniprot.org/uniprotkb/F1N331", "locus": { "chromosome": "7", "start_pos": 75170625, "end_pos": 75136818, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014773", "url": "https://www.ensembl.org/id/ENSBTAG00000014773" } ] } } ], "crossref": [ { "id": "F1N331", "url": "https://alphafold.ebi.ac.uk/entry/F1N331", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014773", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014773", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281227", "url": "https://www.ncbi.nlm.nih.gov/gene/281227", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJE8", "url": "https://www.orthodb.org/?gene=A0A3Q1MJE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N331", "url": "https://www.orthodb.org/?gene=F1N331", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18956", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18956", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18956:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18956:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15905", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15905", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2142845", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2142845", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2160916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005209752", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209752", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N331-1", "url": "https://www.uniprot.org/uniprotkb/F1N331-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFPKAPLKRFNDPSGCAPSPGAYDVKTSEVLKGPVSFQKSQRFQKQKAESQQNLNVDKETTLPVSARKVKTSGLKKESQKNDKDLKMLEKEIRILVQERGAQDRRIQDLEAEVEKMEAKLNAAVREKTSLSASNASLEKQLIELTRTNELLKSKFSEDNNQKNLRILSLELMKLRNKRETKMRSMMAKQEGMEVKLQLTQKNLVESQEKIVQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNHEVLSLKQSLEENITILSKQIEDMKSKYQVLEEEKEDLINRNRERDENLNSEIQSLKERSILEKQEHEELQQKVLQMDSLLQQEKELSSGLQQKLCSFQEEMIKERTLFEGELKQALDELDKLQQKEEQAENLLKQLEEEAESRAAELKRLKEKLKGKEAELEESNAAYTQATLLLQEKHNSTVQNLEDVTAQFESYKASTASELKDLKVQNESLKEKLAKAEQSAEDVRDQVLATENSNQEYARMLLDLQTKSALKEAEMKEITVSSLKRISDLQNQLKQQSEDFKKQLEEEEARKAGKENSIAELTEEMNKWRLLYEELYNKTKPFQLQLDAFEAEKQALLNEHGAAQEQLNNLRDSYAKLLGHQNLKQKIKHVVKLKDENSNLKSEVLKLRAQLTKRKQSEAKLQEELNKVLGIKHFDPSKAFLHESKENFVPKTPLKEGNTNCS", "length": 715, "header": "tr|F1N331-1|F1N331_BOVIN Isoform 1 of Hyaluronan mediated motility receptor OS=Bos taurus OX=9913 GN=HMMR PE=4 SV=4 CANONICAL=F1N331-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJE8/entry", "sequence": { "sequence": "MSFPKAPLKRFNDPSGCAPSPGAYDVKTSEVLKGPVSFQKSQRFQKQKAESQQNLNVDKETTLPVSARKVKTSGLKIRILVQERGAQDRRIQDLEAEVEKMEAKLNAAVREKTSLSASNASLEKQLIELTRTNELLKSKFSEDNNQKNLRILSLELMKLRNKRETKMRSMMAKQEGMEVKLQLTQKNLVESQEKIVQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNHEVLSLKQSLEENITILSKQIEDMKSKYQVLEEEKEDLINRNRERDENLNSEIQSLKERSILEKQEHEELQQKVLQMDSLLQQEKELSSGLQQKLCSFQEEMIKERTLFEGELKQALDELDKLQQKEEQAENLLKQLEEEAESRAAELKRLKEKLKGKEAELEESNAAYTQATLLLQEKHNSTVQNLEDVTAQFESYKASTASELKDLKVQNESLKEKLAKAEQSAEDVRDQVLATENSNQEYARMLLDLQTKSALKEAEMKEITVSSLKRISDLQNQLKQQSEDFKKQLEEEEARKAGKENSIAELTEEMNKWRLLYEELYNKTKPFQLQLDAFEAEKQALLNEHGAAQEQLNNLRDSYAKLLGHQNLKQKIKHVVKLKDENSNLKSEVLKLRAQLTKRKQSEAKLQEELNKVLGIKHFDPSKAFLHESKENFVPKTPLKEGNTNCS", "length": 699, "header": "tr|A0A3Q1MJE8-1|F1N331_BOVIN Computationally mapped isoform of Hyaluronan mediated motility receptor OS=Bos taurus OX=9913 GN=HMMR PE=4 SV=2 CANONICAL=F1N331-1" }, "locus": { "chromosome": "7", "start_pos": 75169341, "end_pos": 75137017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080269.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080269.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071461.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071461.2" } ] } }, { "isoform_ac": "A0AAA9SVB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVB0/entry", "sequence": { "sequence": "MSFPKAPLKRFNDPSGCAPSPGAYDVKTSEVLKGPVSFQKSQRFQKQKAESQQNLNVDKETTLPVSARKVKTSGLKKESQKNDKDLKMLEKEIRILVQERGAQDRRIQDLEAEVEKMEAKLNAAVREKTSLSASNASLEKQLIELTRTNELLKSKFSEDNNQKNLRILSLELMKLRNKRETKMRSMMAKQEGMEVKLQLTQKNLVESQEKIVQLEGKLCASDQVEKYKLDIAQLEENLKEKNHEVLSLKQSLEENITILSKQIEDMKSKYQVLEEEKEDLINRNRERDENLNSEIQSLKERSILEKQEHEELQQKVLQMDSLLQQEKELSSGLQQKLCSFQEEMIKERTLFEGELKQALDELDKLQQKEEQAENLLKQLEEEAESRAAELKRLKEKLKGKEAELEESNAAYTQATLLLQEKHNSTVQNLEDVTAQFESYKASTASELKDLKVQNESLKEKLAKAEQSAEDVRDQVLATENSNQEYARMLLDLQTKSALKEAEMKEITVSSLKRISDLQNQLKQQSEDFKKQLEEEEARKAGKENSIAELTEEMNKWRLLYEELYNKTKPFQLQLDAFEAEKQALLNEHGAAQEQLNNLRDSYAKLLGHQNLKQKIKHVVKLKDENSNLKSEVLKLRAQLTKRKQSEAKLQEELNKVLGIKHFDPSKAFLHESKENFVPKTPLKEGNTNCS", "length": 690, "header": "tr|A0AAA9SVB0-1|F1N331_BOVIN Computationally mapped isoform of Hyaluronan mediated motility receptor OS=Bos taurus OX=9913 GN=HMMR PE=4 SV=1 CANONICAL=F1N331-1" }, "locus": { "chromosome": "7", "start_pos": 75169341, "end_pos": 75137017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130887.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130887.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087924.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087924.1" } ] } }, { "isoform_ac": "F1N331-1", "url": "https://www.uniprot.org/uniprotkb/F1N331/entry", "sequence": { "sequence": "MSFPKAPLKRFNDPSGCAPSPGAYDVKTSEVLKGPVSFQKSQRFQKQKAESQQNLNVDKETTLPVSARKVKTSGLKKESQKNDKDLKMLEKEIRILVQERGAQDRRIQDLEAEVEKMEAKLNAAVREKTSLSASNASLEKQLIELTRTNELLKSKFSEDNNQKNLRILSLELMKLRNKRETKMRSMMAKQEGMEVKLQLTQKNLVESQEKIVQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNHEVLSLKQSLEENITILSKQIEDMKSKYQVLEEEKEDLINRNRERDENLNSEIQSLKERSILEKQEHEELQQKVLQMDSLLQQEKELSSGLQQKLCSFQEEMIKERTLFEGELKQALDELDKLQQKEEQAENLLKQLEEEAESRAAELKRLKEKLKGKEAELEESNAAYTQATLLLQEKHNSTVQNLEDVTAQFESYKASTASELKDLKVQNESLKEKLAKAEQSAEDVRDQVLATENSNQEYARMLLDLQTKSALKEAEMKEITVSSLKRISDLQNQLKQQSEDFKKQLEEEEARKAGKENSIAELTEEMNKWRLLYEELYNKTKPFQLQLDAFEAEKQALLNEHGAAQEQLNNLRDSYAKLLGHQNLKQKIKHVVKLKDENSNLKSEVLKLRAQLTKRKQSEAKLQEELNKVLGIKHFDPSKAFLHESKENFVPKTPLKEGNTNCS", "length": 715, "header": "tr|F1N331-1|F1N331_BOVIN Isoform 1 of Hyaluronan mediated motility receptor OS=Bos taurus OX=9913 GN=HMMR PE=4 SV=4 CANONICAL=F1N331-1" }, "locus": { "chromosome": "7", "start_pos": 75169341, "end_pos": 75137017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019652.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019652.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019652.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019652.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2142845", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2142845", "resource": "Reactome", "description": "Hyaluronan metabolism" }, { "id": "R-BTA-2160916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "resource": "Reactome", "description": "Hyaluronan degradation" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" }, { "name": "cargo receptor activity", "id": "GO:0038024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038024", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" }, { "name": "hyaluronan catabolic process", "id": "GO:0030214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030214", "evidence": [ { "database": "UniProtKB", "id": "F1N331", "url": "https://www.uniprot.org/uniprotkb/F1N331" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" }, { "start_pos": 713, "end_pos": 715, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N331-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 715, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N331-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N331" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N331" }, { "id": "PF15908", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Hyaluronan-mediated motility receptor C-terminal", "eco_id": "ECO_0000259", "start_pos": 554, "end_pos": 710, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 448, "end_pos": 450 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 590, "end_pos": 592 }, { "start_pos": 713, "end_pos": 715 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N703-1", "uniprot_ac": "F1N703", "uniprot_id": "F1N703_BOVIN", "mass": { "chemical_mass": 123371.0, "monoisotopic_mass": 123371.0 }, "refseq": {}, "gene_names": [ { "name": "UBE3C", "type": "recommended", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ], "protein_names": [ { "name": "Ubiquitin-protein ligase E3C", "type": "recommended", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.26", "type": "synonym", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703/entry#names_and_taxonomy" } ] }, { "name": "HECT-type ubiquitin transferase E3C", "type": "synonym", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703/entry#names_and_taxonomy" } ] }, { "name": "RTA-associated ubiquitin ligase", "type": "synonym", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE3C", "url": "https://www.uniprot.org/uniprotkb/F1N703", "locus": { "chromosome": "4", "start_pos": 118580908, "end_pos": 118465448, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008025", "url": "https://www.ensembl.org/id/ENSBTAG00000008025" } ] } } ], "crossref": [ { "id": "F1N703", "url": "https://alphafold.ebi.ac.uk/entry/F1N703", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008025", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008025", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWC5", "url": "https://www.orthodb.org/?gene=A0A3Q1LWC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJH3", "url": "https://www.orthodb.org/?gene=A0A3Q1MJH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N703", "url": "https://www.orthodb.org/?gene=F1N703", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45700", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45700", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45700:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45700:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWC5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWC5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJH3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJH3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N703-1", "url": "https://www.uniprot.org/uniprotkb/F1N703-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQCSIQRSAFDRCASLSQSGGAFPLASGPNLTLLVRQLLFFYRQSEDSKRLIWMYQNLIKHSALFVQQLEGSERLTCLFQIKRLMSLCCRLLQSCNDDSLNVALPMRMLEVFSSEDTYLPVLQDASYVVSVIEQILHYMIQNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTKEVLAAPFTEQIFHFVIPALADARTVFPYEPFLTALLSLEGRRPATSGGAPWLFYFVLTVGDNYLGALSEDGLLAHLRVLQALLSQLPVSPARASGQDAASDSDEEEGEEADRPASTPEDGRLSVLYIAEECLKKLDTKQQTNTLLSLVWRDSASEEAFTLMAAICHTLMVQHRVLVPRARLLYSLAFNARFLRHLWFLISSMTTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELVVLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRNAWRFRRMGRIGPLRSTLDVGLESPPLSVSEERQLAILTQLPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDAFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYRNLLFLKSYEGDVEELGLNFTVVNNDLGEAQAIELKSGGKDIPVTSANRIAYIHLVADYRLNRQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAEHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFQDEALLRSKLLYAIECAAGFELS", "length": 1085, "header": "tr|F1N703-1|F1N703_BOVIN Isoform 1 of Ubiquitin-protein ligase E3C OS=Bos taurus OX=9913 GN=UBE3C PE=3 SV=4 CANONICAL=F1N703-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWC5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC5/entry", "sequence": { "sequence": "MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQCSIQRSAFDRCASLSQSGGAFPLASGPNLTLLVRQLLFFYRQSEDSKRLIWMYQNLIKHSALFVQQLEGSERLTCLFQIKRLMSLCCRLLQSCNDDSLNVALPMRMLEVFSSEDTYLPVLQDASYVVSVIEQILHYMIQNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTKEVLAAPFTEQIFHFVIPALADARTVFPYEPFLTALLSLEGRRPATSGGAPWLFYFVLTVGDNYLGALSEDGLLAHLRVLQALLSQLPVSPARASGQDAASDSDEEEGEEADRPASTPEDGRLSVLYIAEECLKKLDTKQQTNTLLSLVWRDSASEEAFTLMAAICHTLMVQHRVLVPRARLLYSLAFNARFLRHLWFLISSMTTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELVVLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRNAWRFRRMGRIGPLRSTLDVGLESPPLSVSEERQLAILTQLPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDAFARHYYFLGRMLGKVVELKSGGKDIPVTSANRIAYIHLVADYRLNRQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAEHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFQDEALLRSKLLYAIECAAGFELS", "length": 1014, "header": "tr|A0A3Q1LWC5-1|A0A3Q1LWC5_BOVIN Computationally mapped isoform of HECT-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=UBE3C PE=4 SV=2 CANONICAL=F1N703-1" }, "locus": { "chromosome": "4", "start_pos": 118579473, "end_pos": 118465717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078229.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078229.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059707.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059707.2" } ] } }, { "isoform_ac": "A0A3Q1MJH3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJH3/entry", "sequence": { "sequence": "MFSFEGDFKTRPKVSLGGASRKCSIQRSAFDRCASLSQSGGAFPLASGPNLTLLVRQLLFFYRQSEDSKRLIWMYQNLIKHSALFVQQLEGSERLTCLFQIKRLMSLCCRLLQSCNDDSLNVALPMRMLEVFSSEDTYLPVLQDASYVVSVIEQILHYMIQNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTKEVLAAPFTEQIFHFVIPALADARTVFPYEPFLTALLSLEGRRPATSGGAPWLFYFVLTVGDNYLGALSEDGLLAHLRVLQALLSQLPVSPARASGQDAASDSDEEEGEEADRPASTPEDGRLSVLYIAEECLKKLDTKQQTNTLLSLVWRDSASEEAFTLMAAICHTLMVQHRVLVPRARNSEG", "length": 407, "header": "tr|A0A3Q1MJH3-1|F1N703_BOVIN Computationally mapped isoform of Ubiquitin-protein ligase E3C OS=Bos taurus OX=9913 GN=UBE3C PE=3 SV=2 CANONICAL=F1N703-1" }, "locus": { "chromosome": "4", "start_pos": 118512045, "end_pos": 118465717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085066.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085066.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071492.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071492.2" } ] } }, { "isoform_ac": "F1N703-1", "url": "https://www.uniprot.org/uniprotkb/F1N703/entry", "sequence": { "sequence": "MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQCSIQRSAFDRCASLSQSGGAFPLASGPNLTLLVRQLLFFYRQSEDSKRLIWMYQNLIKHSALFVQQLEGSERLTCLFQIKRLMSLCCRLLQSCNDDSLNVALPMRMLEVFSSEDTYLPVLQDASYVVSVIEQILHYMIQNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTKEVLAAPFTEQIFHFVIPALADARTVFPYEPFLTALLSLEGRRPATSGGAPWLFYFVLTVGDNYLGALSEDGLLAHLRVLQALLSQLPVSPARASGQDAASDSDEEEGEEADRPASTPEDGRLSVLYIAEECLKKLDTKQQTNTLLSLVWRDSASEEAFTLMAAICHTLMVQHRVLVPRARLLYSLAFNARFLRHLWFLISSMTTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELVVLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRNAWRFRRMGRIGPLRSTLDVGLESPPLSVSEERQLAILTQLPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDAFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYRNLLFLKSYEGDVEELGLNFTVVNNDLGEAQAIELKSGGKDIPVTSANRIAYIHLVADYRLNRQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAEHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFQDEALLRSKLLYAIECAAGFELS", "length": 1085, "header": "tr|F1N703-1|F1N703_BOVIN Isoform 1 of Ubiquitin-protein ligase E3C OS=Bos taurus OX=9913 GN=UBE3C PE=3 SV=4 CANONICAL=F1N703-1" }, "locus": { "chromosome": "4", "start_pos": 118579473, "end_pos": 118465717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010553.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010553.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010553.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010553.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ], "pmid": "" }, { "name": "protein K29-linked ubiquitination", "id": "GO:0035519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035519", "evidence": [ { "database": "UniProtKB", "id": "F1N703", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 726, "end_pos": 728, "annotation": "n_glycosylation_sequon" }, { "start_pos": 888, "end_pos": 890, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" }, { "start_pos": 983, "end_pos": 985, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N703-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1085, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N703-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N703" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 746, "end_pos": 1085, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.26", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.26" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 726, "end_pos": 728 }, { "start_pos": 888, "end_pos": 890 }, { "start_pos": 93, "end_pos": 95 }, { "start_pos": 983, "end_pos": 985 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N590-1", "uniprot_ac": "F1N590", "uniprot_id": "F1N590_BOVIN", "mass": { "chemical_mass": 59310.0, "monoisotopic_mass": 59310.0 }, "refseq": { "ac": "XP_010812909", "name": "neuropilin and tolloid-like protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812909" }, "gene_names": [ { "name": "NETO2", "type": "recommended", "evidence": [ { "id": "F1N590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ] }, { "name": "NETO2", "type": "synonym", "evidence": [ { "id": "XP_010812909", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812909" } ] } ], "protein_names": [ { "name": "Neuropilin and tolloid like 2", "type": "synonym", "evidence": [ { "id": "F1N590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N590/entry#names_and_taxonomy" } ] }, { "name": "neuropilin and tolloid-like protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010812909", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812909" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NETO2", "url": "https://www.uniprot.org/uniprotkb/F1N590", "locus": { "chromosome": "18", "start_pos": 15484074, "end_pos": 15549702, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014370", "url": "https://www.ensembl.org/id/ENSBTAG00000014370" } ] } } ], "crossref": [ { "id": "F1N590", "url": "https://alphafold.ebi.ac.uk/entry/F1N590", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014370", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014370", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520056", "url": "https://www.ncbi.nlm.nih.gov/gene/520056", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520056", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520056", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KECIYVL", "url": "https://omabrowser.org/oma/group/KECIYVL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQ17", "url": "https://www.orthodb.org/?gene=A0A3Q1MQ17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N590", "url": "https://www.orthodb.org/?gene=F1N590", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24251", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24251", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24251:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24251:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010812909", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812909", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ17", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ17-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N590-1", "url": "https://www.uniprot.org/uniprotkb/F1N590-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALEQLCSVLKVLLVTVLVVEGIAVAQKTQDGQNIGMKHVPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTGSTFFCHSNMCINNSLVCNGIQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEMSADLADLSEELDSYQKTRRSSTASRCIHDHHCGSQAPSAKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF", "length": 525, "header": "tr|F1N590-1|F1N590_BOVIN Isoform 1 of Neuropilin and tolloid like 2 OS=Bos taurus OX=9913 GN=NETO2 PE=4 SV=2 CANONICAL=F1N590-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQ17-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ17/entry", "sequence": { "sequence": "MALEQLCSVLKVLLVTVLVVEGIAVAQKTQDGQNIGMKHVPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEQKKKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEMSADLADLSEELDSYQKTRRSSTASRCIHDHHCGSQAPSAKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF", "length": 487, "header": "tr|A0A3Q1MQ17-1|F1N590_BOVIN Computationally mapped isoform of Neuropilin and tolloid like 2 OS=Bos taurus OX=9913 GN=NETO2 PE=4 SV=1 CANONICAL=F1N590-1" }, "locus": { "chromosome": "18", "start_pos": 15548487, "end_pos": 15485078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074854.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074854.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071804.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071804.1" } ] } }, { "isoform_ac": "A0AAA9S4N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N0/entry", "sequence": { "sequence": "MLKAVLLVTVLVVEGIAVAQKTQDGQNIGMKHVPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTGSTFFCHSNMCINNSLVCNGIQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEMSADLADLSEELDSYQKTRRSSTASRCIHDHHCGSQAPSAKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF", "length": 518, "header": "tr|A0AAA9S4N0-1|F1N590_BOVIN Computationally mapped isoform of Neuropilin and tolloid like 2 OS=Bos taurus OX=9913 GN=NETO2 PE=4 SV=1 CANONICAL=F1N590-1" }, "locus": { "chromosome": "18", "start_pos": 15549407, "end_pos": 15485078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080889.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080889.1" } ] } }, { "isoform_ac": "F1N590-1", "url": "https://www.uniprot.org/uniprotkb/F1N590/entry", "sequence": { "sequence": "MALEQLCSVLKVLLVTVLVVEGIAVAQKTQDGQNIGMKHVPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTGSTFFCHSNMCINNSLVCNGIQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEMSADLADLSEELDSYQKTRRSSTASRCIHDHHCGSQAPSAKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF", "length": 525, "header": "tr|F1N590-1|F1N590_BOVIN Isoform 1 of Neuropilin and tolloid like 2 OS=Bos taurus OX=9913 GN=NETO2 PE=4 SV=2 CANONICAL=F1N590-1" }, "locus": { "chromosome": "18", "start_pos": 15548487, "end_pos": 15485078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019107.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019107.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019107.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019107.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520056", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520056", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "C6K2K4-1", "protein_name": "Neuropilin and tolloid-like protein 2", "gene_name": "Neto2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALEQLCAVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHVPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGVTSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLREKEISADLADLSEELDNYQKLRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQTHDCPEQALEDRVMEEIPCEIYVRGRDDSAQASISIDF", "length": 525 }, "evidence": [ { "id": "F1N590", "url": "https://omabrowser.org/oma/group/F1N590/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3L833-1", "protein_name": "Neuropilin and tolloid like 2", "gene_name": "NETO2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALEQLCSVLKVLLITIFVVEGIAVAQKTQDGQNIGIKHIPSTQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTGSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGITSGIVFVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEISADLADLSEELDNYQKTRRSSTASRCIHDHHCGSQAPSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF", "length": 525 }, "evidence": [ { "id": "F1N590", "url": "https://omabrowser.org/oma/group/F1N590/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BNJ6-1", "protein_name": "Neuropilin and tolloid-like protein 2", "gene_name": "Neto2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALEQLCAVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDERYYIEPSFECRFDHLEIRDGPFGFSPLIDRYCGMKSPALIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSAIENLKAKFCSTVANDVMLKTGVGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGLFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLREKEISADLADLSEELDNYQKLRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQAHECPEQALEDRVMEEIPCEIYVRGRDDSAQASISIDF", "length": 525 }, "evidence": [ { "id": "F1N590", "url": "https://omabrowser.org/oma/group/F1N590/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NC67-1", "protein_name": "Neuropilin and tolloid-like protein 2", "gene_name": "NETO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEKKKAGVFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEISADLADLSEELDNYQKMRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQGHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF", "length": 525 }, "evidence": [ { "id": "F1N590", "url": "https://omabrowser.org/oma/group/F1N590/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0098696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098696", "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "pmid": "" }, { "name": "neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0099645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099645", "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ionotropic glutamate receptor binding", "id": "GO:0035255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035255", "evidence": [ { "database": "UniProtKB", "id": "F1N590", "url": "https://www.uniprot.org/uniprotkb/F1N590" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N590-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 525, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N590-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N590" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N590" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 159, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 311, "end_pos": 313 }, { "start_pos": 385, "end_pos": 387 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 475, "end_pos": 477 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Y7-1", "uniprot_ac": "F1N6Y7", "uniprot_id": "F1N6Y7_BOVIN", "mass": { "chemical_mass": 138514.0, "monoisotopic_mass": 138514.0 }, "refseq": {}, "gene_names": [ { "name": "EIF5B", "type": "recommended", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 5B", "type": "recommended", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.3", "type": "synonym", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7/entry#names_and_taxonomy" } ] }, { "name": "Translation initiation factor IF-2", "type": "synonym", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RYK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYK8#function" }, { "database": "UniProtKB", "id": "ARBA00053410", "url": "https://www.uniprot.org/uniprotkb/ARBA00053410#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ63#function" }, { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF5B", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7", "locus": { "chromosome": "11", "start_pos": 4544968, "end_pos": 4455741, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034255", "url": "https://www.ensembl.org/id/ENSBTAG00000034255" } ] } } ], "crossref": [ { "id": "F1N6Y7", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Y7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01887", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01887", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03703", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03703", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16266", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16266", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFAVMLC", "url": "https://omabrowser.org/oma/group/EFAVMLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MS04", "url": "https://www.orthodb.org/?gene=A0A3Q1MS04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N6Y7", "url": "https://www.orthodb.org/?gene=F1N6Y7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43381:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43381:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11987", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11987", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14578", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14578", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MS04", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS04-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKKQKNKNEDSAKDDIDLDALAAEIEGAGAAREQEPQKAKGKKKKEKKRQDFDEDDILKELEELSWEAQGIKADREPAAVKPTENNEDEPISKQDKKKKGQKGKKQSFEDNDSEELEEKDSKSKKTAKPKVEMYSGSDDDDDFNKLSKKAKGKAQKSNKKRDASEEDEDNSKRIKERMRAHSSGESGDESDEFLQSRKGQKKNQKNKPGPTVESGNEDDDSSFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELESGKKDLGKPKESQRKPEEEALKSKVTLDSGAAPASEEKGEGPIGAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKKKKPPQQMENKVSEPVELSAAAEVVEQGLPEKEETPPPVEPEEEEETEDAGLDDWEAMASDEERETEENTVHIEVKENPEEEEEEEEEEEEEEESEDEEEEEGDSEGSEGEDDDEKVSDEKDAGKTLDKKPSKDVSSESEDDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTRDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLICLLVELTQTMLSKRLAQCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEVPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQFIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEVNHKQVDVAKKGQEVCVKIEPIPGESPKMYGRHFEATDILVSKCELVCRPNLGRTYKASDQFWNQILSGVWPWSYTASLHTS", "length": 1223, "header": "tr|F1N6Y7-1|F1N6Y7_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5B OS=Bos taurus OX=9913 GN=EIF5B PE=1 SV=4 CANONICAL=F1N6Y7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MS04-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS04/entry", "sequence": { "sequence": "AKDDIDLDALAAEIEGAGAAREQEPQKAKGKKKKEKKRQDFDEDDILKELEELSWEAQGIKADREPAAVKPTENNEDEPISKQDKKKKGQKGKKQSFEDNDSEELEEKDSKSKKTAKPKVEMYSGSDDDDDFNKLSKKAKGKAQKSNKKRDASEEDEDNSKRIKERMRAHSSGESGDESDEFLQSRKGQKKNQKNKPGPTVESGNEDDDSSFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELESGKKDLGKPKESQRKPEEEALKSKVTLDSGAAPASEEKGEGPIGAEGW", "length": 297, "header": "tr|A0A3Q1MS04-1|F1N6Y7_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 5B OS=Bos taurus OX=9913 GN=EIF5B PE=1 SV=3 CANONICAL=F1N6Y7-1" }, "locus": { "chromosome": "11", "start_pos": 4485746, "end_pos": 4484099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084017.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084017.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057191.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057191.3" } ] } }, { "isoform_ac": "A0AAA9RYK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYK8/entry", "sequence": { "sequence": "MGKKQKNKNEDSAKDDIDLDALAAEIEGAGAAREQEPQKAKGKKKKEKKRQDFDEDDILKELEELSWEAQGIKADREPAAVKPTENNEDEPISKQDKKKKGQKGKKQSFEDNDSEELEEKDSKSKKTAKPKVEMYSGSDDDDDFNKLSKKAKGKAQKSNKKRDASEEDEDNSKRIKERMRAHSSGESGDESDEFLQSRKGQKKNQKNKPGPTVESGNEDDDSSFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELESGKKDLGKPKESQRKPEEEALKSKVTLDSGAAPASEEKGEGPIGAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKKKKPPQQMENKVSEPVELSAAAEVVEQGLPEKEETPPPSEDEEEEEGDSEGSEGEDDDEKVSDEKDAGKTLDKKPSKDVSSESEDDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTRDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLICLLVELTQTMLSKRLAQCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEVPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQFIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEVNHKQVDVAKKGQEVCVKIEPIPGESPKMYGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII", "length": 1163, "header": "tr|A0AAA9RYK8-1|F1N6Y7_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 5B OS=Bos taurus OX=9913 GN=EIF5B PE=1 SV=1 CANONICAL=F1N6Y7-1" }, "locus": { "chromosome": "11", "start_pos": 4531607, "end_pos": 4455902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130085.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130085.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076212.1" } ] } }, { "isoform_ac": "A0AAA9TJ63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ63/entry", "sequence": { "sequence": "MRILGDGTRNETRNDDIDLDALAAEIEGAGAAREQEPQKAKGKKKKEKKRQDFDEDDILKELEELSWEAQGIKADREPAAVKPTENNEDEPISKQDKKKKGQKGKKQSFEDNDSEELEEKDSKSKKTAKPKVEMYSGSDDDDDFNKLSKKAKGKAQKSNKKRDASEEDEDNSKRIKERMRAHSSGESGDESDEFLQSRKGQKKNQKNKPGPTVESGNEDDDSSFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELESGKKDLGKPKESQRKPEEEALKSKVTLDSGAAPASEEKGEGPIGAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKKKKPPQQMENKVSEPVELSAAAEVVEQGLPEKEETPPPVEPEEEEETEDAGLDDWEAMASDEERETEENTVHIEVKENPEEEEEEEEEEEEEEESEDEEEEEGDSEGSEGEDDDEKVSDEKDAGKTLDKKPSKDVSSESEDDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTRDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLICLLVELTQTMLSKRLAQCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEVPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQFIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEVNHKQVDVAKKGQEVCVKIEPIPGESPKMYGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII", "length": 1219, "header": "tr|A0AAA9TJ63-1|F1N6Y7_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 5B OS=Bos taurus OX=9913 GN=EIF5B PE=1 SV=1 CANONICAL=F1N6Y7-1" }, "locus": { "chromosome": "11", "start_pos": 4531607, "end_pos": 4483403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135076.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135076.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097208.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097208.1" } ] } }, { "isoform_ac": "F1N6Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7/entry", "sequence": { "sequence": "MGKKQKNKNEDSAKDDIDLDALAAEIEGAGAAREQEPQKAKGKKKKEKKRQDFDEDDILKELEELSWEAQGIKADREPAAVKPTENNEDEPISKQDKKKKGQKGKKQSFEDNDSEELEEKDSKSKKTAKPKVEMYSGSDDDDDFNKLSKKAKGKAQKSNKKRDASEEDEDNSKRIKERMRAHSSGESGDESDEFLQSRKGQKKNQKNKPGPTVESGNEDDDSSFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELESGKKDLGKPKESQRKPEEEALKSKVTLDSGAAPASEEKGEGPIGAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKKKKPPQQMENKVSEPVELSAAAEVVEQGLPEKEETPPPVEPEEEEETEDAGLDDWEAMASDEERETEENTVHIEVKENPEEEEEEEEEEEEEEESEDEEEEEGDSEGSEGEDDDEKVSDEKDAGKTLDKKPSKDVSSESEDDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTRDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLICLLVELTQTMLSKRLAQCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEVPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQFIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEVNHKQVDVAKKGQEVCVKIEPIPGESPKMYGRHFEATDILVSKCELVCRPNLGRTYKASDQFWNQILSGVWPWSYTASLHTS", "length": 1223, "header": "tr|F1N6Y7-1|F1N6Y7_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5B OS=Bos taurus OX=9913 GN=EIF5B PE=1 SV=4 CANONICAL=F1N6Y7-1" }, "locus": { "chromosome": "11", "start_pos": 4544894, "end_pos": 4455902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034635.7", "url": "https://www.ensembl.org/id/ENSBTAT00000034635.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034522.6", "url": "https://www.ensembl.org/id/ENSBTAP00000034522.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 212, "start_aa": "Thr", "end_pos": 212, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr212", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YTY9-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "EIF5B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTVNPDLIVNYLTAAASQWFHPEDSELLCAKDDIDIDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSIEAQGGKADREPSTGKVENDNEDSLSKQDKKRKGKSKKANLENDYDSEEMEDKDRKSKKTQKAKQDVLSGSDDDDLEIQPKKNKGKTQKSNKKHELSEDEANVKKSKERVGTLSTGESGDESDEFSQPRKGQKKNQKPKSTAALGSGDEEEESSFKVKTVAQKKAEKKERERKKREEEKAKLRKLKEKEELEGGKEAAKPKEAPKKAEEKASPDVAAAPGPGGKGEIPAGAEADDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKMKEEEERAKREEEERIRRLEELEAKRKEEERLEQERKERKKQKEKERKERLKKEGKLLTKAQREARARAEATLKLLQAQGVEVPSKDSVPKKRPIYEDKKKKKQQQPENKEVSESLEVTSPAEDAVELETLVKEEPPLPAEPEEKEEEEEDDGGLDDWEAMVSDEDEEKESKPVHIEVKEQNEVDEEEEEEEEDEEEEEEESEESDDAESEGSEDEDEKTSDERDADSQATGKQSVEKKPSKEISSDSEYDSDDDRTKEERAYDKAKRRIEKRRAENSKNANTEKLRAPVICVLGHVDTGKTKILDKLRHTHVQDSEAGGITQQIGATNVPLEAINEQTKMVKNFDRENIKIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDTDVAVTLKKQKKNTKDEFEERAKAIIVEFAKQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIALLVELTQTMLTKRLAECQELRAQVMEVKALPGMGTTIDVILINGRLREGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVVAAQGVKILGKDLEKTLAGLPLLVAHKEDEVPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKMKILPQFIFNSRDPIVMGVVVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKPVEVAKKGQEVCVKIEPIPGESPKMYGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII", "length": 1237 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2GUV7-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "Eif5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKKQKNKSEDSTKDDTDLGALAAEIEGAGAAKEQEPQKGKGKKKKEKKKQDFDENDILRELEELSLEAQGIGADRDAATVKPTENNEEESASKQDKKKKGQKGKKTSFDENDSEELEDKDSKSKKPARPNSEVLLSGSEDADDPNKLSKKGKKAQKSTKKRDGSEEDEDNSKRSKERSRVNSSGESGGESDEFLQSRKGQKKNQKNKSVPTIDSGNEDDDSSFKIKTVAQKKAEKKERERKKREEEKAKLRKVKEKEELEKGRKEQSKQREPQKRPDEEVLVLRGTPDAGAASEEKGDIAATLEDDNEGDKKKKDKKKKKTEKDDKEKEKKKGPSKSTVKAIQEALAKLREEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEVTLRHLQAQGVEVPSKDSLPKKRPVYEDKKKKKTPQQLESKEALETVEVSAPVEVVDQGVPEKEETPPSVDAEEDEETEDAGLDDWEAMASDEEREKEGNMIHIEVEENPEEEEEEEEDEDEEDSEDEEDEGDSEGSDGDEEDYKLSDEKDLGKAGDTKPNKDASSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHGKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINILKSKKCPFIVALNKIDRLYDWKKSPDSDVAVTLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKDDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKMKILPQYIFNSRDPIVIGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII", "length": 1216 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O60841-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "EIF5B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII", "length": 1220 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P39730-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "FUN12", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAKKSKKNQQNYWDEEFEEDAAQNEEISATPTPNPESSAGADDTSREASASAEGAEAIEGDFMSTLKQSKKKQEKKVIEEKKDGKPILKSKKEKEKEKKEKEKQKKKEQAARKKAQQQAQKEKNKELNKQNVEKAAAEKAAAEKSQKSKGESDKPSASAKKPAKKVPAGLAALRRQLELKKQLEEQEKLEREEEERLEKEEEERLANEEKMKEEAKAAKKEKEKAKREKRKAEGKLLTRKQKEEKKLLERRRAALLSSGNVKVAGLAKKDGEENKPKKVVYSKKKKRTTQENASEAIKSDSKKDSEVVPDDELKESEDVLIDDWENLALGDDDEEGTNEETQESTASHENEDQNQGEEEEEGEEEEEEEEERAHVHEVAKSTPAATPAATPTPSSASPNKKDLRSPICCILGHVDTGKTKLLDKIRQTNVQGGEAGGITQQIGATYFPIDAIKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELTQKRMSKQLMYLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALLTPQPLRELRLKSEYVHHKEVKAALGVKIAANDLEKAVSGSRLLVVGPEDDEDELMDDVMDDLTGLLDSVDTTGKGVVVQASTLGSLEALLDFLKDMKIPVMSIGLGPVYKRDVMKASTMLEKAPEYAVMLCFDVKVDKEAEQYAEQEGIKIFNADVIYHLFDSFTAYQEKLLEERRKDFLDYAIFPCVLQTLQIINKRGPMIIGVDVLEGTLRVGTPICAVKTDPTTKERQTLILGKVISLEINHQPVQEVKKGQTAAGVAVRLEDPSGQQPIWGRHVDENDTLYSLVSRRSIDTLKDKAFRDQVARSDWLLLKKLKVVFGIE", "length": 1002 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q05D44-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "Eif5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKKQKNKSEDSTKDDTDLGALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDENDILRELEELSLEAQGIRADRDAAAVKPTENNEEESASKQDKKKKGQKGKKTSFDENDSEELEDKDSKSKKTARPNSEAPLSGSEDADDSNKLSKKGKKAQKSTKKRDGSEEDEDNSKRSKERSRVNSSGESGGESDEFLQSRKGQKKNQKNKSVPTVDSGNEDDDSSFKIKTVAQKKAEKKEREKKKRDEEKAKLRKMKEKEELEKGKKEQSKQREPQKRPEEEVLTLRGTPDTGAASEEKGDTAAALEDDNEGDKKKKDKKKKKTEKDEKEKEKKKGPSKSTVKAIQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEVTLRHLQAQGVEVPSKDSLPKKRPVYEDKKKKKTPQQLESKEVSETLEISAPVEAVDQGGPEKEETPPSVEPEEEEDTEDAGLDDWEAMASDEEREKEGNMIHIEVEENPEEEEEEEEEEEEEESEDEEEEGDSEGSDGDEEDCKLSDEKDSGKAGDTKPSKDASSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHGKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINILKSKKCPFIVALNKIDRLYDWKKSPDSDVAVTLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKDDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKMKILPQYIFNSRDPIVIGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII", "length": 1216 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54XP6-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "eif5b", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGPKQRVRKDNYWDSGEADKDREEAEKLHKKGQQQSDSDSDSDDIPISKKKPTSKFAPVDESSSESEESSSEEEVQKKPSKPAAKQSKKVAPTNNKKKPVVESSSSEEEESESESEESSEEDTKKKPSKPAAKQSKKVAPTNNNNNKKKPVVESSSEESESESEESSSEEDTKKKPSKPAAKQNKKAPAKKAAAVESSSESEEESSSSEEEEKPTKPTQNNNNKKNNAKKPPAAKPSAAKQQAKKPAPKKPEEPEVLSGFLLKQRQEEERIAREKEEKRIREEEEKKRAAEQKIIDDEKARLKSIENSKKRAEKKEKQAGAAAEADRMAKLAKLGVNISAVGEKKEKSTNKTKSGGKKQNQVSSITESVEKLKIEEPTSAPKDDVVEVMDSWDNDDYETVEEIQKKKEEEAKRKEEEEEAQRLAAKEEKKKAKAAAAAAAAALIPTTDPTTTFADKSYRSPIICILGHVDTGKTSLLDKIRNTNVQGGEARGITQQIGASFIPVDAIKEQTKSFAEKIKMDFKLPGLLLIDTPGHESFNNLRSRGSGLCDLAILVIDIMHGLQAQTLESINLLRMRKTPFIVALNKVDRIYDWKPCVNTDFKEAYKIQSKSAAQEFDYKVKDIIAALAGQELNAELYWRNKDHRKYVSLVPTSANTGEGISDLMLVVIQLMQKLMLDKVEFTNQLQCTLLEVKVIEGFGTTIDVVLVNGTLNEGDKIVVSGFNGPIETSIRSLLTPPPLRESRVKSQFINHKSIRAAMGIKIVAPGLEKAVPGTSLHVVGPNDDIEKIRAEAKREVDSVLNDVETSGIGVSVQASTLGSLEAFLNFLKKIKIPVANVAIGPVHKKHIMNASIMLDKDPKYAILLAFDVKIEESAIQAANEMKVQVLSDETIYLFEEKLKKHFGAIKEKLRAETASICVWPCILEVTNVFRNSNPILVGVRVKEGTLRIGTPICVPESNCADVGKVIGIKLNEKDVTLAKKDDVVSVAIDDNNTKTTIYRHFDDKKQWMSKITRESLDALKEGWSEDLTKQDIQLLKFMKTVYKIQ", "length": 1045 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SRE1-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVICWKISEPMGRKKPSSSRGGDDEQPPAASSLVGAESKKKAVQSDEEDKYSINTEEEKVVITGKKKSNKKVTQKHDDDDDFTEAVPENGFVGKKKKSKGKNRGGSVSFALLSGKEETDDNESNGDKDDEPVISFTGKKNASNKGKKGFAVSAFDALGGDKDDEEVDGDEEQVSPITFSGKKTRSSKSSKKTTNKVALPDEEEGTMGDEESLEITFSGKKKGSIVLASLGDDSVADETSQAKTPDTKSVEVIETGKIKKKKKNKNKVARTLEEEDDLDKLLAELGETPAAERPASSTPEVEKVQAQPGPVAPVENAGEKEGEKETVETAAAKKKKKKKEKDKEKKAAAAATSSVEAKEEKQEESVTEPLQPKKKDAKGKAAEKKIPKHVREMQEALARRQEAEERKKKEEEEKLRKEEEERRRQEELEAQAEEAKRKRKEKEKEKLLRKKLEGKLLTAKQKTEAQKREAFKNQLLAAGRGLPVADDVGDATSSKRPIYANKKKPSRQKGNDTSVQVEDEVEPQENHAATLGEVGSEDTEKVDLLESANTGEKSGPADVAQENGVEEDDEWDAKSWDNVDLKIDDKEEEAQPVVKKELKAHDSDHETEKPTAKPAGMSKLTTGAVKAISEVEDAATQTKRAKKGKCLAPSEFIKEGGENLRSIICCIMGHVDSGKTKLLDCIRGTNVQEGEAGGITQQIGATYFPAKNIRERTRELKADAKLKVPGLLVIDTPGHESFTNLRSRGSSLCDLAILVVDIKHGLEPQTIESLNLLRMRNTEFIIALNKVDRLYGWKTCKNAPIVKAMKQQNKDVTNEFNIRLTDIITQFKEQGLNTEIYYKNKEMGETFSIVPTSAKSGEGVPDLLLWLVQWAQKTMVEKLTYVDEVQCTVLEVKVIEGHGTTIDVVLVNGELHEGDQIVVCGLQGPIVTTIRALLTPHPMKELRVKGTYLHHKEIKAAQGIKITAQGLEHAIAGTSLHVVGPDDDIEAMKESAMEDMESVLSRIDKSGEGVYVQTSTLGSLEALLEFLKTPAVNIPVSEGYNEGWSDAREEKEYATILAFDVKVTTEARELADEMGVKIFCADIIYQLFNQFQVYIENIKEEKKKESAGEAVFPCVLQILPNCVFNKRDPIILGVKVHDGILKIGTPICVPGREFTDIGRIASIENNHKPVDYAEKGDEVAIKIVASNREEQKMFGRHFDMEDELVSHISRRSIDILKADYMVSQG", "length": 1224 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VZP5-1", "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "eIF5B", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVKAKKGKKEILTKVEGGSSVDEISDVDSDQLSLNNKQNHALKGNQAGDDDVKAVTKGVKKLNVKGKGKAGKNDDSDEEEVVPAKGKASKKSAFELLMDDDEQDEPAAQESQSEKEEKVVVSKPQKNEKKGKKAKRKGKDDDDEDLDKVLAELQAEYAGEAAPAATTVVSPEELADEFSKKKKNKKQAKQAAVAENAGEDEASDDEEGGSTVKSAAQKKKEKKERQKREAALAKQKAATEPKPKPVEKPAPEPEPVATEEVQPAAEEEEEKSSKNKKKGKKDKKAEPEEEKKDAKKKGMSASMVAAMQEQLRKRKEEEERLEREEAERIRLEDEREEARLEAVRLEAERKEKKKQREAERKARLKAEGKLLTKKQKEDRARAQALLESLKAQGLEIPDPNDKRPTRPGTRIRPNKKKGPKEEAAEEEAKAAEAEAQSAAAAAAAAAAEKAEEERVKESWDATDSEAEPEPEEETSQATNNGKTEAAEEENEDTDDDEDDDDDEDDSDDSDGDSDDSREVSVLANDPESRRLRAEARILKRQAEAEKKRSTDELRAGVVCVLGHVDTGKTKILDKLRRTHVQDSEAGGITQQIGATNVPIEAIKEQTKYVKAAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGMGNLLFMIADFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNAYVEYKEVKAAQGVKIAAKDLEKAIAGINLLIAHKPDEVEICTEEVARELKSALSHIKLAQTGVHVQASTLGSLEALLEFLRTSKIPYSAIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEMADSLGVKIFQADIIYHLFDKFTAYREELKQKKREEFRSVAVFPCKLRILPQFVFNSRDPIVMGVMVENGIVKVGTPICVPSKEFVDIGIVTSIESNHKQIEFARKGQEICVKIDPIPGESPKMFGRHFEADDMLISKISRQSIDACKDYFRDDLIKADWALMVELKKLFEIL", "length": 1144 }, "evidence": [ { "id": "F1N6Y7", "url": "https://omabrowser.org/oma/group/F1N6Y7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "regulation of translational initiation", "id": "GO:0006446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006446", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" }, { "name": "ribosome assembly", "id": "GO:0042255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042255", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y7", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-BTA-72671", "name": "eIF5B:GTP is hydrolyzed and released", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T169-1", "F1N6Y7-1" ], "evidence": [ { "id": "R-BTA-72671", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72671" } ] }, { "id": "R-BTA-72672", "name": "The 60S subunit joins the translation initiation complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T169-1", "F1N6Y7-1" ], "evidence": [ { "id": "R-BTA-72672", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72672" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3T169", "gene_name": "RPS3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q3T169", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T169" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q3T169", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T169" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Y7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1223, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Y7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Y7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 628, "end_pos": 845, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.3", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3" }, { "id": "3.6.5.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 212 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q9W0-1", "uniprot_ac": "F6Q9W0", "uniprot_id": "F6Q9W0_BOVIN", "mass": { "chemical_mass": 78662.0, "monoisotopic_mass": 78662.0 }, "refseq": {}, "gene_names": [ { "name": "SLC3A1", "type": "recommended", "evidence": [ { "id": "F6Q9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ] } ], "protein_names": [ { "name": "Amino acid transporter heavy chain SLC3A1", "type": "recommended", "evidence": [ { "id": "F6Q9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0/entry#names_and_taxonomy" } ] }, { "name": "Neutral and basic amino acid transport protein", "type": "synonym", "evidence": [ { "id": "F6Q9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 3 member 1", "type": "synonym", "evidence": [ { "id": "F6Q9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0/entry#names_and_taxonomy" } ] }, { "name": "b(0,+)-type amino acid transporter-related heavy chain", "type": "synonym", "evidence": [ { "id": "F6Q9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC3A1", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0", "locus": { "chromosome": "11", "start_pos": 26735016, "end_pos": 26701406, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017421", "url": "https://www.ensembl.org/id/ENSBTAG00000017421" } ] } } ], "crossref": [ { "id": "F6Q9W0", "url": "https://alphafold.ebi.ac.uk/entry/F6Q9W0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017421", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017421", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11359", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11359", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PNGEKWA", "url": "https://omabrowser.org/oma/group/PNGEKWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MSG3", "url": "https://www.orthodb.org/?gene=A0A3Q1MSG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6Q9W0", "url": "https://www.orthodb.org/?gene=F6Q9W0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10357:SF179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357:SF179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00128", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00128", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-352230", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MSG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q9W0-1", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEDKSKRDSIGLNAKEGQTNNGFVQNEDIRETDLDPSSPVVGPQHNTVDILGPGEPDVKDVRPYAGMPKEVLFQFSGQACYRIPREVLFWLTVASVLVLIAATIAIIAISPKCLDWWQAGPMYQIYPRSFRDSNKDGDGDLKGIQDKLDYITTLNIKTVWITSFYKSSLKDFRHGVEDFREIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDKHAWFQWSRNRTGKYTDYYIWHDCNHENGTTIPPNNWLSVYGNSSWHFDEVRKQCYFHQFMKEQPDLNFRNPDVQEEIKEIIQFWLSKGVDGFSFDALPFLLEAKHLRDEAQVNKTQIPDMVTHYSQLHHDFTTTQVGMHDIVRSFRQTMNQYSREPGRYRFMGTEAHGESITKTMVYYGLPFIQEADFPFNSYLSKLDKPSGNSVSEIITSWMENMPEGKWPNWMTGGPDSVRLTSRLGEKYVNIMNMLVFTLPGTPITYYGEEIGMRNILAANLNETYDAGTLFSKSPMQWDNSSNAGFSEGNHTWLPTSSDYHTVNVDVQKTQPRSALKLYQELSLLHANELLLGRGWFCFLGNYNHSIMYTRELDGINRIFLMVLNFGESSVLNLKEMISNIPTRVRIRLSTNSAYGGREVDTHAVTLASGEGLILEYNTRNLLHRQTAFKERCFVSNRACYSRVLNILYSLC", "length": 685, "header": "tr|F6Q9W0-1|F6Q9W0_BOVIN Isoform 1 of Amino acid transporter heavy chain SLC3A1 OS=Bos taurus OX=9913 GN=SLC3A1 PE=4 SV=1 CANONICAL=F6Q9W0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MSG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSG3/entry", "sequence": { "sequence": "MAEDKSKRDSIGLNAKEGQTNNGFVQNEDIRETDLDPSSPVVGPQHNTVDILGPGEPDVKDVRPYAGMPKEVLFQFSGQACYRIPREVLFWLTVASVLVLIAATIAIIAISPKCLDWWQAGPMYQIYPRSFRDSNKDGDGDLKGIQDKLDYITTLNIKTVWITSFYKSSLKDFRHGVEDFREIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDKHAWFQWSRNRTGKYTDYYIWHDCNHENGTTIPPNNWLSVYGNSSWHFDEVRKQCYFHQFMKEQPDLNFRNPDVQEEIKDMVTHYSQLHHDFTTTQVGMHDIVRSFRQTMNQYSREPGRYRFMGTEAHGESITKTMVYYGLPFIQEADFPFNSYLSKLDKPSGNSVSEIITSWMENMPEGKWPNWMTGGPDSVRLTSRLGEKYVNIMNMLVFTLPGTPITYYGEEIGMRNILAANLNETYDAGTLFSKSPMQWDNSSNAGFSEGNHTWLPTSSDYHTVNVDVQKTQPRSALKLYQELSLLHANELLLGRGWFCFLGNYNHSIMYTRELDGINRIFLMVLNFGESSVLNLKEMISNIPTRVRIRLSTNSAYGGREVDTHAVTLASGEGLILEYNTRNLLHRQTAFKERCFVSNRACYSRVLNILYSLC", "length": 645, "header": "tr|A0A3Q1MSG3-1|F6Q9W0_BOVIN Computationally mapped isoform of Amino acid transporter heavy chain SLC3A1 OS=Bos taurus OX=9913 GN=SLC3A1 PE=4 SV=1 CANONICAL=F6Q9W0-1" }, "locus": { "chromosome": "11", "start_pos": 26734677, "end_pos": 26701419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084611.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084611.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057435.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057435.1" } ] } }, { "isoform_ac": "F6Q9W0-1", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0/entry", "sequence": { "sequence": "MAEDKSKRDSIGLNAKEGQTNNGFVQNEDIRETDLDPSSPVVGPQHNTVDILGPGEPDVKDVRPYAGMPKEVLFQFSGQACYRIPREVLFWLTVASVLVLIAATIAIIAISPKCLDWWQAGPMYQIYPRSFRDSNKDGDGDLKGIQDKLDYITTLNIKTVWITSFYKSSLKDFRHGVEDFREIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDKHAWFQWSRNRTGKYTDYYIWHDCNHENGTTIPPNNWLSVYGNSSWHFDEVRKQCYFHQFMKEQPDLNFRNPDVQEEIKEIIQFWLSKGVDGFSFDALPFLLEAKHLRDEAQVNKTQIPDMVTHYSQLHHDFTTTQVGMHDIVRSFRQTMNQYSREPGRYRFMGTEAHGESITKTMVYYGLPFIQEADFPFNSYLSKLDKPSGNSVSEIITSWMENMPEGKWPNWMTGGPDSVRLTSRLGEKYVNIMNMLVFTLPGTPITYYGEEIGMRNILAANLNETYDAGTLFSKSPMQWDNSSNAGFSEGNHTWLPTSSDYHTVNVDVQKTQPRSALKLYQELSLLHANELLLGRGWFCFLGNYNHSIMYTRELDGINRIFLMVLNFGESSVLNLKEMISNIPTRVRIRLSTNSAYGGREVDTHAVTLASGEGLILEYNTRNLLHRQTAFKERCFVSNRACYSRVLNILYSLC", "length": 685, "header": "tr|F6Q9W0-1|F6Q9W0_BOVIN Isoform 1 of Amino acid transporter heavy chain SLC3A1 OS=Bos taurus OX=9913 GN=SLC3A1 PE=4 SV=1 CANONICAL=F6Q9W0-1" }, "locus": { "chromosome": "11", "start_pos": 26734677, "end_pos": 26701419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023161.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023161.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023161.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023161.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-352230", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-352230", "resource": "Reactome", "description": "Amino acid transport across the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C011-1", "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "SLC3A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVDKELKGLPMELSEKGGVENNGFVQNEAFDDRDTDTSSQDEIPKTCAVDVSPAAVAEPALQPYAGMPKEVLLKFSSQARYRVTREILFWLTIAAAVLLVSATIAIIALSPKCLDWWQDGPIYQVYPRSFKDSNMDGNGDLKGIQEKLDHITHLNIKTIWITSFYKSPLKDAGYGAEDFYDIDPMFGSMRDFEDLLASIHDRGLKVIMDFIPNHTSDKHQWFQLSRNRTGKYTDYYIWQDCVQAGAAISAPNNWVSVYGNSSWQYDDVRKQCYFHQFGKEQPDLNFRNPAVQQEIHDVIKFWLGKGVDGFNFIAVKFLLEATHLRDEPQVNKSQNPESITAYSELYHDYTTTQVGMHDIIRSFRQTMDQYSSEPGRYRFMGSDSDEKEDIEATMMYYGTTFVQEADFPFNLHLINMKNLSGNSVFEAVNMWMKNMPEGKWPNWAVGSPNTARISSRFGSEYVRVINMLLLTLPGTPITYYGEEIGMENIASENVTSPEKSPMQWNGNLNAGFTKGNSSWIPVNSDYESVNAEVQMTRFNSTLNLYRELTLLRNSELPIHRGWMCSIWNDSDVFVYVRELDGLDSVFMMVLNFGQESTIDLKAIVPDLPSKAVVRLSTDFSNNGKAVDTTIIKTDVGEGLVLEYKTGKPVHNMEAFRENCFVAEKACYSSAFNLLYMNC", "length": 678 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QEA9-1", "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "slc3a1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLTRVTNIDAVELQEGIQNAAFREDDDDNNGDIVCIRRVSSLPEESEYTQIKPYAGMPKEVLMLYSNKPCYRIPREVIFWLVIACTLALIAMTAAIVALSPRCMSWWQLSPIYQVYPRSFKDSNADGVGDLRGIKEKLSHFEYLNIKAIWISPFYKSPMRDFGYDVEDFRDVDPLFGTMEDFDDLLTSMHDKGLKLIMDYIPNHTSDKHVWFQLSRNYTEPYTDYYIWVNCTADKHPNNWVSVFGNSTWEYDEIRQQCYFHQFLKEQPDLNYRNPLVLQEMTDIIHFWLKKGVDGFRMDAVKHMLEATHLRDEPQVNPDQDPSTVDTEFELYHDYTYTQAGLHEILTDWRIQMDTYSREPGRYRFMVMESYDYEEIDKTMRYYGTNYAKESDFPFNFYLLDLPDNLSGNYAKSIVERWMSNMPKGKWPNWVVGNHDKPRIGSSAGKEYVRALNMLLLTLPGTPTTYYGEEIGMVDVNISVIQDPAGQYDPSKSRDPQRTPMQWNNELNAGFSESLNGTWLDIASDYRTVNVEVQQDDTSSTISQYRALSLLRSSNVILSRGWFCYVWNDVNVFAYLRELDGLSKGFLVVLNFGKETTTDLSSVKELPDSLTLHLSTESITQTEFPKSRIPTSQGQGLLLEYSSSQKFHLNHQSQCYVSEKACYLPALDILYQC", "length": 674 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S5K2-1", "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "SLC3A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEDKSKRGSIGMSLKGGQTNNGFVQNEDIRERDPNPEDRQQHNAVDMLGPGDPDLKDIRPYAGMPKEVLFQFSGQARYRVPREVLFWLTVASVLALIAATISIIAISPKCLDWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQDKLDYLTTLNIKTVWITSFYKSSLKDFRYGVEDFREIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDKHAWFLSRTRTGKYTDYYIWHDCTQEDGITIPPNNWLSVYGNSSWHFDEIRNQCYFHQFLKEQPDLNFRNPDVQEEIKEIIQFWLSKGVDGFSFDAVQFLLEAKHLRDETQVNKTQIPATITHYSELYHDFTTTQVGMHDIVRSFRQMMDQYSREPGRYRFMGTEAQGESIAGTMMYYGLPFIQEADFPFNSYFGQLDTPSGDSVAEVILSWMENMPEGKWPNWMTGGPDNARLTSRLGEEYVNVMNMLIFTLPGTPITYYGEEIGMNILATSLNETYDADTLLSKSPMQWDNSSNAGFSEGSHTWLPTGSDYHTVNVDVQKTQPRSALKLYQELSLLHANELLLSRGWFCYLRNDNYSVVYTRELNGIDRVLLMVLNFGESSLLNLKEVISNIPTRVRIRLSTNSVYTGREVDTHAISVDRGEGLILEYNTKNLLHQQAAFRDRCFISNRACYSSVFNILYSLC", "length": 680 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P40884-1", "protein_name": "Oligo-1,6-glucosidase IMA5", "gene_name": "IMA5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTIIHNPKWWKEATVYQIYPASFKDSNNDGWGDLAGITSKLDYVKELGVDAIWVCPFYDSPQEDMGYDIANYEKVWPRYGTNEDCFQMIEEAHKRGIKVIVDLVINHCSEEHEWFKESRSSKANPKRDWFFWRPPKGYDEKGNPIPPNNWRSFFGGSAWRYDEKTGEFFLHVFALGQPDFNWENEECRKAIYDSSVGYWLRHNVDGFRIDVGSMYSKVEGLPDAPITDPTVPYQKGTEFFINGPRIHEYHKEMHNYMLSQVPEGKEIMTVGEVGIGNEDDFRVYTSAKEGELNMMFNFKHTSVGENPKCKYELIPFTLKDFKLALAESFLFIENTDCWSTIYLENHDQPRSVSRFGSDSPKWREISSKMLATLIISLTGTVFIYQGQELGMPNFKNRKIEQIKCVEGTGTYAAIKRDYGEDSEKMKKFFEALALISRDHGRTPFPWSADEPSAGFSKDAKPWIDMNESFRDGINAEAELKDKNSVFFFWKKALQVRKEHKDILVYGHNFQFIDLDNDKLFMFTKDTDNKKMFAVFNFSSDNTDFSVPDNEASYTMFFGNYANSNGDSRTLQPWEGRLYLLK", "length": 581 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q07837-1", "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "SLC3A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFKGVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC", "length": 685 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54S16-1", "protein_name": "maltose alpha-D-glucosyltransferase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTTPNGLGNSIENMLSLSSGDTLTQQFISSPPLNNSTDEFLDYSEHERSEMSVSNNLWYKEAIFYEVYVRAFCDIEGTGNGGISGITNKLDYLHTLGVDCIWLLPIYPSPLKDDGYDISDYCDIHPDYGTLNDFKILVKAVHERNMKIIADFIPNHCSDKHKWFQSARLSRDSPYRDYFVWSDSPQKYKDARIIFLDVEQSNWTWDEAAGQYYWHRFYKEQPDLNFDNPKVQQEMLNIIDFWLNLGIDGFRVDAVPYLFEREGTSCENLPETHEFLKKMRKFIDDKYPGRIILAEACQMPDEVRKYFGDGDEFHMGFHFPVMPRIYMSIMRSKSECLRSIMENTPEIPNTCQWVTFLRNHDELTLEMVTKDERKEMWDFYAPVPRMRINLGIRRRLAPLMGGDQRKIELAYSLLFTLPGSPIIYYGDEICMGDNIWLEDRHGVRTPMQWSDQPPNGGFSTSNKLYAPVIDDPEYGYQKVNVVESEKDPSSLYQVIRQMIQRRRKHLSFGHGSFQWVNSDNPHIASYMRICGIDRMFIVQNLSDQVQKVTLHTHATPVLPSLSTHQSSICGGGGSLHRRTASNSGDGIASGIGSRIGGTNTSGGGGGGNNDGISNITSNFGNTLTVDGAGGNLSGSKVTPIPTRKVHTHYQQSNINRQQHLQPLTTKEEYEASKDTKQPFVSFLNVETASYDEQSHYLIDILTDYQVMVDQKGYVTMDLEPYQFFWFSMGEITTLMGDGSKSRDLRRKSIQINDPINLHHRNSHFADPIDE", "length": 770 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q64319-1", "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "Slc3a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNEDKDKRDSIQMSMKGCRTNNGFVQNEDIQEQDPDSRDTPQSNAVSIPAPEEPQLKVVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGATIAIIIISPKCLDWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTIWITSFYKSPLKDFRYAVEDFKEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWHNCTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFHQFLKEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTVTRYSELYHDFTTTQVGMHDLVRDFRQTMNQFSREPGRYRFMGTEVSAESTERTMVYYGLSFIQEADFPFNKYLATLDTLSGHTVYEAITSWMENMPEGKWPNWMIGGPETSRLTSRVGSEYVNAMNMLLFTLPGTPITYYGEEIGMGDISITNLNERYDTNALLSKSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHARELLLSRGWFCLLRDDNHSVVYTRELDGIDKVFLVVLNFGESSTVLNLQETISDVPTKLRIRLSTNPASKGSDVDTHAVSLEKGEGLILEHSMKTLLHHQKAFRDKCFISNRACYSSVLDLLYSSC", "length": 683 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91WV7-1", "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "Slc3a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEDKGKRDPIQMSLKGCRTNNGFVQNEDIPEQDPDPGSRDTPQPNAVSIPAPEEPHLKAVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGATIAIIVISPKCLDWWQAGPIYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTLWITSFYKSSLKDFRYAVEDFKEIDPIFGTMKDFENLVAAIHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWHNCTHVNGVTTPPNNWLSVYGNSSWHFDEVRKQCYFHQFLKEQPDLNFRNPAVQEEIKEIITFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTVTHYSELYHDFTTTQVGMHDIVRDFRQTMNQYSREPGRYRFMGAEASAESIERTMMYYGLPFIQEADFPFNKYFTTIGTLSGHTVYEVITSWMENMPEGKWPNWMTGGPETPRLTSRVGSEYVNAMHMLLFTLPGTPITYYGEEIGMGDISVTNFNESYDSTTLVSKSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHATELVLSRGWFCLLRDDSHSVVYTRELDGIDNVFLVVLNFGESSTVLNLQGIISDLPPELRIRLSTNSASKGSAVDTRAISLEKGEGLVLEHSTKAPLHQQAAFRDRCFVSSRACYSSALDILYSSC", "length": 685 }, "evidence": [ { "id": "F6Q9W0", "url": "https://omabrowser.org/oma/group/F6Q9W0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" }, { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" }, { "name": "L-cystine transport", "id": "GO:0015811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015811", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" }, { "name": "aspartate transmembrane transport", "id": "GO:0015810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015810", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" }, { "name": "L-glutamate transmembrane transport", "id": "GO:0015813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015813", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" }, { "name": "brush border membrane", "id": "GO:0031526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031526", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F6Q9W0", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6Q9W0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 685, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6Q9W0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6Q9W0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6Q9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9W0" }, { "id": "SM00642", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycosyl hydrolase family 13 catalytic", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 550, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 246, "end_pos": 248 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 513, "end_pos": 515 }, { "start_pos": 523, "end_pos": 525 }, { "start_pos": 577, "end_pos": 579 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QT67-1", "uniprot_ac": "F6QT67", "uniprot_id": "F6QT67_BOVIN", "mass": { "chemical_mass": 120688.0, "monoisotopic_mass": 120688.0 }, "refseq": {}, "gene_names": [ { "name": "INVS", "type": "recommended", "evidence": [ { "id": "F6QT67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ] } ], "protein_names": [ { "name": "Inversin", "type": "recommended", "evidence": [ { "id": "F6QT67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QT67/entry#names_and_taxonomy" } ] }, { "name": "Nephrocystin-2", "type": "synonym", "evidence": [ { "id": "F6QT67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QT67/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MSY1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSY1#function" }, { "database": "UniProtKB", "id": "ARBA00059836", "url": "https://www.uniprot.org/uniprotkb/ARBA00059836#function" }, { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INVS", "url": "https://www.uniprot.org/uniprotkb/F6QT67", "locus": { "chromosome": "8", "start_pos": 65273530, "end_pos": 65136441, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009806", "url": "https://www.ensembl.org/id/ENSBTAG00000009806" } ] } } ], "crossref": [ { "id": "F6QT67", "url": "https://alphafold.ebi.ac.uk/entry/F6QT67", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009806", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009806", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529698", "url": "https://www.ncbi.nlm.nih.gov/gene/529698", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MSY1", "url": "https://www.orthodb.org/?gene=A0A3Q1MSY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QT67", "url": "https://www.orthodb.org/?gene=F6QT67", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198:SF194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198:SF194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MSY1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSY1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QT67-1", "url": "https://www.uniprot.org/uniprotkb/F6QT67-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRSENLFFAGSSLASQVHAAAINGDKGALHKLIIGNSALKDKEDQFGRTPLMYCVLADRLDCADTLLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHKSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRREAEQQKGRLSPDSCRPHAPLCLPRTQAEPHRQSRAPSKQPPCSDKAQGPERKACRRSPGRGSPSRAPQKEQQLSSDLQRTEPRKPNETAREHSKGRSACVHFSPSEGSDGNRRPGVCPAEKPRGETAGEQHCDKGKGSSKQPSHVKGAGPDAEGEEPSWAATSLPQQDSHWKASRRQDAAPKAMRASQKRRSQELRGGRRSPAGSSRPGSAKGEVVHPGQSPLHHRTPRNTVTQDKLAGGTSSDLPPSTEVLRSGVRKLGTSARSEDTRLPKETDPAPGPLPGQTVNIDLLPVELRLQIIQRERSRKELFRRKNKAAAIIQRAWRSYQLRKHLSHLLHVKQLGARDMDRWNRECLALILQVWRKELELKPPKTMAVSKTTKSPPKGSSGTKPTRHSVLKQIYGSQEGKVRQPTRSSKAHSVLGLNSVSNLQCIHLLKNSGKSQNFSYNLQSANPSRNKLKLRLPKEEDCARGARIASADFKFSD", "length": 1088, "header": "tr|F6QT67-1|F6QT67_BOVIN Isoform 1 of Inversin OS=Bos taurus OX=9913 GN=INVS PE=4 SV=1 CANONICAL=F6QT67-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MSY1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSY1/entry", "sequence": { "sequence": "MNRSENLFFAGSSLASQVHAAAINGDKGALHKLIIGNSALKDKEDQFGRTPLMYCVLADRLDCADTLLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHKSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRREAEQQKGRLSPDSCRPHAPLCLPRTQAEPHRQSRAPSKQPPCSDKAQGPERKACRRSPGRGSPSRAPQKEQQLSSDLQRTEPRKPNETAREHSKGRSACVHFSPSEGSDGNRRPGVCPAEKPRELRLQIIQRERSRKELFRRKNKAAAIIQRAWRSYQLRKHLSHLLHVKQLGARDMDRWNRECLALILQVWRKELELKPPKTMAVSKTTKSPPKGSSGTKPTRHSVLKQIYGSQEGKVRQPTRSSKAHSVLGLNSVSNLQCIHLLKNSGKSQNFSYNLQSANPSRNKLKLRLPKEEDCARGARIASADFKFSD", "length": 918, "header": "tr|A0A3Q1MSY1-1|F6QT67_BOVIN Computationally mapped isoform of Inversin OS=Bos taurus OX=9913 GN=INVS PE=4 SV=1 CANONICAL=F6QT67-1" }, "locus": { "chromosome": "8", "start_pos": 65272585, "end_pos": 65139515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069660.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069660.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073266.1" } ] } }, { "isoform_ac": "F6QT67-1", "url": "https://www.uniprot.org/uniprotkb/F6QT67/entry", "sequence": { "sequence": "MNRSENLFFAGSSLASQVHAAAINGDKGALHKLIIGNSALKDKEDQFGRTPLMYCVLADRLDCADTLLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHKSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRREAEQQKGRLSPDSCRPHAPLCLPRTQAEPHRQSRAPSKQPPCSDKAQGPERKACRRSPGRGSPSRAPQKEQQLSSDLQRTEPRKPNETAREHSKGRSACVHFSPSEGSDGNRRPGVCPAEKPRGETAGEQHCDKGKGSSKQPSHVKGAGPDAEGEEPSWAATSLPQQDSHWKASRRQDAAPKAMRASQKRRSQELRGGRRSPAGSSRPGSAKGEVVHPGQSPLHHRTPRNTVTQDKLAGGTSSDLPPSTEVLRSGVRKLGTSARSEDTRLPKETDPAPGPLPGQTVNIDLLPVELRLQIIQRERSRKELFRRKNKAAAIIQRAWRSYQLRKHLSHLLHVKQLGARDMDRWNRECLALILQVWRKELELKPPKTMAVSKTTKSPPKGSSGTKPTRHSVLKQIYGSQEGKVRQPTRSSKAHSVLGLNSVSNLQCIHLLKNSGKSQNFSYNLQSANPSRNKLKLRLPKEEDCARGARIASADFKFSD", "length": 1088, "header": "tr|F6QT67-1|F6QT67_BOVIN Isoform 1 of Inversin OS=Bos taurus OX=9913 GN=INVS PE=4 SV=1 CANONICAL=F6QT67-1" }, "locus": { "chromosome": "8", "start_pos": 65272585, "end_pos": 65139515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012932.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012932.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012932.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012932.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "F6QT67", "url": "https://www.uniprot.org/uniprotkb/F6QT67" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1048, "end_pos": 1050, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 690, "end_pos": 692, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QT67-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1088, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QT67-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QT67" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1048, "end_pos": 1050 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 247, "end_pos": 249 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 690, "end_pos": 692 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7G8-1", "uniprot_ac": "F1N7G8", "uniprot_id": "F1N7G8_BOVIN", "mass": { "chemical_mass": 164618.0, "monoisotopic_mass": 164618.0 }, "refseq": { "ac": "XP_024855827", "name": "sister chromatid cohesion protein PDS5 homolog B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855827" }, "gene_names": [ { "name": "PDS5B", "type": "recommended", "evidence": [ { "id": "F1N7G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ] }, { "name": "PDS5B", "type": "synonym", "evidence": [ { "id": "XP_024855827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855827" } ] } ], "protein_names": [ { "name": "PDS5 cohesin associated factor B", "type": "synonym", "evidence": [ { "id": "F1N7G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G8/entry#names_and_taxonomy" } ] }, { "name": "sister chromatid cohesion protein PDS5 homolog B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024855827", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855827" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDS5B", "url": "https://www.uniprot.org/uniprotkb/F1N7G8", "locus": { "chromosome": "12", "start_pos": 28311935, "end_pos": 28495485, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011597", "url": "https://www.ensembl.org/id/ENSBTAG00000011597" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011597", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011597", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19953", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19953", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533890", "url": "https://www.ncbi.nlm.nih.gov/gene/533890", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533890", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533890", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPPAYNM", "url": "https://omabrowser.org/oma/group/YPPAYNM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUX7", "url": "https://www.orthodb.org/?gene=A0A3Q1MUX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7G8", "url": "https://www.orthodb.org/?gene=F1N7G8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12663:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12663:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2468052", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2468052", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2470946", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2470946", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855827", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855827", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7G8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7G8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQISWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEVLVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGGKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTTNVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELDKPRSRKKTPVTDSEEKLGMDDLSKLVQEQKPKGSQRGRKRGHTASESDEQQWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKKSGPSAAEEEEEEERQSGNTEQKSKSKQHRTSRRAQQSRAESPDTTAAEPTQSTPQKGRGGPSKTPSPSQPPKKVRVGRSKQAATKENDSSEEIDVFQGSSPVNDENPQEETEEEEVSTVNVRRRGSKRERR", "length": 1449, "header": "tr|F1N7G8-1|F1N7G8_BOVIN Isoform 1 of PDS5 cohesin associated factor B OS=Bos taurus OX=9913 GN=PDS5B PE=3 SV=2 CANONICAL=F1N7G8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX7/entry", "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQISWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEVLVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGGKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTTNVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELDKPRSRKKTPVTDSEEKLGMDDLSKLVQEQKPKGSQRGRKRGHTASESDEQQWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKKSGPSAAEEEEEEERQSGNTEQKSKSKQHRTSRRAQQSRVGRSKQAATKENDSSEEIDVFQGSSPVNDENPQEETEEEEVSTVNVRRRGSKRERR", "length": 1412, "header": "tr|A0A3Q1MUX7-1|F1N7G8_BOVIN Computationally mapped isoform of PDS5 cohesin associated factor B OS=Bos taurus OX=9913 GN=PDS5B PE=3 SV=1 CANONICAL=F1N7G8-1" }, "locus": { "chromosome": "12", "start_pos": 28425497, "end_pos": 28312939, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080256.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080256.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058692.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058692.1" } ] } }, { "isoform_ac": "F1N7G8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7G8/entry", "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQISWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEVLVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGGKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTTNVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELDKPRSRKKTPVTDSEEKLGMDDLSKLVQEQKPKGSQRGRKRGHTASESDEQQWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKKSGPSAAEEEEEEERQSGNTEQKSKSKQHRTSRRAQQSRAESPDTTAAEPTQSTPQKGRGGPSKTPSPSQPPKKVRVGRSKQAATKENDSSEEIDVFQGSSPVNDENPQEETEEEEVSTVNVRRRGSKRERR", "length": 1449, "header": "tr|F1N7G8-1|F1N7G8_BOVIN Isoform 1 of PDS5 cohesin associated factor B OS=Bos taurus OX=9913 GN=PDS5B PE=3 SV=2 CANONICAL=F1N7G8-1" }, "locus": { "chromosome": "12", "start_pos": 28425497, "end_pos": 28312939, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015410.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015410.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015410.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015410.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533890", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533890", "resource": "KEGG Pathway" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2468052", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2468052", "resource": "Reactome", "description": "Establishment of Sister Chromatid Cohesion" }, { "id": "R-BTA-2470946", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2470946", "resource": "Reactome", "description": "Cohesin Loading onto Chromatin" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IP12-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "pds5b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAHSKNRATDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSAQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFQVINNGHNQKVHMHMVDLMSSIVCEGDSVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSVSDLSEHVFDLILELYNIDNHLLLSVLPQLEFKLKSNDNDERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPVRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTASKKDLSLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQAEAGKEAAKQISWIKDKLLHIYYQNSIDDRLLVERIFAQYLVPHNLETTERMKCLYYLYATLDGNAVKALNEMWKCQNMLRHHVKDLLDLVKQPKSDSYNKAVFSKVMVITRNLPDPGKTQDFVKKLAQVLEEDEKIRKQLETLVSPSCSCKQAEVCVKEITKKLGSPKQPSNPFLEMVKFLLERIAPVHIDTESISALIKQVNKSIEGTADDEDEGVPTEQAIRAGLELLKVLSFTHPVSFHSAETFESLLGCLKMDDEKVAEAALQIFKNTGNKLEDSFPHIKSVLLPVLQHKAKKGPPRQAKYAIHCIHAMFSNRDTHFAQIFEPLHKGLDTDNMEQLITPLTTLGHLAMLAPEQFAAPLKSLVANFIVKDLLMNDRIPGKKTTKLWVPDDEVSPETSAKIQGLKLMVRWLLGVKNNQSKSGNSTLRMLTAILSSDGDLTEQGKMGKPDMSRLRLAAGCAILRLAQEPCYHEIITLEQYQLCALVINDECYQVRQAFAQKLHKGLCRLRLPLEYLAVFTLCAKDPVKERRAHARQCLVKNINLRREYLKQHAAVSEKLISLLPEYVVPYAIHLLVHDPDYVKVQDIEQLKDIKEALWFVLEILMAKNENNSHAFIRKMVENIKQTKDGQCPDDAKINEKLYTVCDVAMNIVISKSTTYSLESPKDPVLPARYFTQPDKNFSNTKNYLPPEMKSFFTPGKPKAANVLGAVNKPLSATGKLQTKLSRMETISNASSNSNPSSPGRSKGRLDSGDHSENEDISMKSPSETEKPTRGRKRGAGASQDDKGQESKPKRGRKKAANTSTDDAEDQWGEDSSLAEANLETEDEQNSPPKRGRRGRPPKSAAAKEETPSKGRRGRRKTAPPVEEDNEDEQQEEEDEDEEEDAGSENMEVKPKGRRGRKPKVDVSETASDSVETTPQKRRGRPPKSQTAARKASGGRSRAAAHQEEESEEEMDTVQQSEEDEDESVDSSPKVRRKVGRRDRR", "length": 1408 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A9J7GV50-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog B isoform X8", "gene_name": "Pds5b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKTLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQISWVKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEILVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESIRYLSLQISRFLSHAFNSALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGNKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNITVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTANVLGAVNKPLSSAGKQSQSKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELEKPRSRKKAPVADPEEKLGMDDLTKLVQEQKPKGSQRGRKRGRIASESDEQQWPEEKRHKEELLENEDEQNSPPKKGKRGRPPKPLGGGTSKEEPTMKTSKKGSKKKPVPSVVDDDDEEERQIGNTEQKSKSKQHRSSKRAQQSRAESPESSAVESTQSTPQKGRGRPSKTPSPSQSKKNVRVGRSKQTATKENDSSEEMDVLQASSPISDDTAQEGAEEEDISAGNVRRRSSKRERR", "length": 1465 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1Z8S6-1", "protein_name": "Precocious dissociation of sisters 5, isoform A", "gene_name": "pds5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MADIVYPTGCRPLVEDLGTDELIRRLKTLANVLQTMDQDDNLYQQYIPLALHLLDDFFMQHPSRDVQLLIACCVADVLRVYAPEAPYKEQDQIKTIFKFFIKQLHGLKDPRDPSFKRYFYLLENLAFVKSFNMCFELEDCQEIFQDLFSTIFKIVNDQHSVKVTNFFLDVLSPLITEADNLSVELLDLILINIVEPYKSNNKFACQLTEQLLTKTGDALESTIKMFFNRALVMDKPNTKLSITNKIYDIIYELNRINAGLLCSVLPQLENKLLSTDDAERLKATTLLSRMFSEKDSQLAKKYPNLLKIFFGRFCDITEPVRIKCVQSSMHFLLNHPSLQHDITEKLRLRNHDLDEVVRHEVVMAIVETAKRDFTLVLEAPDLLEIVRERTLDKKYKIRRDAMNGLAYIYKRAICEPNDLSTGLKVRVDWIKNKILHGYYKVGLEDRLLVERLLITCLVPYKLAPEERMKKLYHLLGDLDANATKAFVELQKNQMKTRNTVSDWIKLHHSKEFTPRVLSQLSAKQANIAKLLPDPLKAAEYLTQFSNNLRKDAQLLRCINIVLKRDVSCRECADTMGVLLKKLGAHVQSNLYYNTVKMLIERVASVMVDKESIGVLISLIEQCIEKGSMCEEIGISAQEAGERGLKLLAMLSYVFSAHFFTDTSLRHLISLLSYEQDYVAPLVLKTLTHLGRYQPLIDDPTPAILDELAPVCKDFALIGTPKQAKHAVRCIFVNSQSSASTDGATSGAGSASTTTQTVHPIFNEIIETLRLKLTPNCEHQRTKIVTLGHIAYNMPQAFLTPIKNMIARRIVKELLIQEVPAQRDYELPEDSDWCAQEKLPPDTLCKLDALKAMARWLLGLRTDEHAAQKTFRMLAAFVNQRGDLLGQNRLCGAEKSWLRLGAACAMLKVCEQKGVGDQYSAEQYLQLSQLMADPVPEVREIFARKLHKGLSRSLPRNCLPLDFMGLYVLAGLETERKLQDLVRHYAETDVNKRREYLKTVAMTSPDSSTESQSLHILPDYMLAFAIPVLVHDPRFTNHEDYVQLRKMEKCLRFILEPLMAKRETFVHSFYKQLLQLIKHREFSLGSDKRDNYKMWALCDLAMYIIDSKFSPFDGNTSTFSMPLALPEMYYKEPAVANFQNNDVYIPLDVYTLGAKSTSKAAATAMTTSRAAVAPKRPAEQSIMDDENPQENNLFDNIRAADTTEPMAKRTRAGAASAKS", "length": 1218 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F4I735-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "PDS5B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEKTPTQIVSELCSRLLQLSRPNKDSLVKLLREVANTLSKIDQPSATNKEKGLKLIEAELRPLKKSIIKHALLKNRDNDVSLLVTVCVSELFRILAPHLPFEDEYLRDIFTLFIAEFSELSDTVSPYFSKRAKILETVSRLKFCLLMLDEDCQDLVHEMFNMFFSLVREHHQQSLINQKSMKTQQRKANTQQTQHSLFNNILAIMSDVLEEEANSSFVVVILENLVKEGEDTTSGADKLASSLIERCADRLEPLICSFLTSCFMEKDSIQTNLKDSYHEIIFKISLIAPQMLLAVIPKLTQELLTDQVDVRIKALNLAGRIFAQPKHCLSSYVETYQDLYAEFLRRFSDKSAEVRMAALKCGKQCYFANPSGNKASGVLTAIQERLLDFDDRVRTQALIVACDIMKFNMKYVPLNLISEASERLRDKKISVRKKALQKLTEVYQDYCDKCSEGDMTITDNFEQIPCKILLLCCEKNCEEFRSQNLELVLSDDLFPRLLPVEERMRHWVQCFAIMNHIHLKSLNSILSQKRRLQNELRHCLTLWRKAKVDNIEEAQRKKKSYFVKLSACFPDASEAEDLFEKLDRMRDASIFDVLTLLLEELSSTNAQIIKEKFLKMIGVKHSLFEFLRILSTKCSPSIFSSEHVQCLLNQLCGSTSANTQLKAPSIKLLLVILNMFPSYLRGSEKQFLKLLEENDSAADELIVVLSKAAPYISVNFGDYYPVLEKVCLEGTRSQTKCAVSAISSLAGSSEKSVFSELCEMLMDSLLCGRNIPTTLQSLACVGQYSVLEYDNIYEDITSYIYRVFQAEPSDNQLPCDQSSGCCNSCKLKIYGLKTLVKSFLPRHGQVVRKIDDLLNILKKTLKSQGHDGIKSCEDTGANVRLAAAKAVLLLSRKWDLHISPEVFRLTILMAKDSNAFITKTFLTKLYKLLTEHMIPSRYACAFSFSLSSPCRDLHDDSFRYINGFINKATRESRTCRDLDQGESLTDSPVYMTVFLIHVLAHDPEFPSEDCRDEHIYARFCGPLFSVLQVLLSINNNGFTIKETAPFLFCIFRAIKRAEDAVDSRKTPRLHILADIGYSAVNILNSIVVTSPQAPRSILLPSSLYSLTSITDNQNKAKSRTRNALEQSFIERIVHIFQSQISMHDQRCQKDSLAVGSEDKVLPPLLGNQIETSITGSTEASQNNTRCSRKRTHLGEHISCNSLSLRTVESEIPIKKLERHTTCAKESVKASVSNKITSSKHSGVVSALKDISNHGEAIIGQRIKLLSPTDGCFYPGTVEKFNSKSNSHKIIFDNGDVELVCLDSESWETLSHESMGQQERLGKETESYGSRNCVPEISHTLAKVTAQKQTTTTKQQNKKVPAKLNPPAVPCFMMSAKSKKGNSDSGEGSVSEVTDTSDNIGPRRSRRQRIS", "length": 1410 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q04264-1", "protein_name": "Sister chromatid cohesion protein PDS5", "gene_name": "PDS5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAKGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEVISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPGLFKKYNISTGASIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTLFKDQIRTLKTIIKDLDDPDAEKNDNLSLEEALKTLYKASKTLKDQVDFDDTFFFTKLYDFAVESKPEITKYATKLIALSPKAEETLKKIKIRILPLDLQKDKYFTSHIIVLMEIFKKFPHVLNDDSTDIISYLIKEVLLSNQVVGDSKKEIDWVEDSLLSDTKYSAIGNKVFTLKLFTNKLRSIAPDVPRDELAESFTEKTMKLFFYLIASGGELISEFNKEFYPTPSNYQTKLRCVAGIQVLKLARISNLNNFIKPSDIIKLINLVEDESLPVRKTFLEQLKDYVANELISIKFLPLVFFTAYEPDVELKTTTKIWINFTFGLKSFKKGTIFERALPRLIHAIAHHPDIVGGLDSEGDAYLNALTTAIDYLLFYFDSIAAQENFSLLYYLSERVKNYQDKLVEDEIDEEEGPQKEEAPKKHRPYGQKMYIIGELSQMILLNLKEKKNWQHSAYPGKLNLPSDLFKPFATVQEAQLSFKTYIPESLTEKIQNNIKAKIGRILHTSQTQRQRLQKRLLAHENNESQKKKKKVHHARSQADDEEGDGDRESDSDDDSYSPSNKNETKKGHENIVMKKLRVRKEVDYKDDEDDDIEMT", "length": 1277 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q4VA53-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "Pds5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYSLQSAAGKDAAKQISWVKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEALVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNITVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTANVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKREDPDLSELEKPRSRKKAPVTDPEEKLGMDDLTKLVQEQKPKGSQRGRKRGRTASDSDEQQWPEEKRHKEELLENEDEQNSPPKKGKRGRPPKPLGGGTSKEEPTMKTSKKGNKKKLVPPVVDDDEEEERQIGNTEHKSKSKQHRTSKRAQQRAESPETSAVESTQSTPQKGRGRPSKAPSPSQPPKKIRVGRSKQVATKENDSSEEMDVLQASSPVSDDTTQEGAEEEDISVGNVRRRSSKRERR", "length": 1446 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q552Q7-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog", "gene_name": "pds5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MATRATRAASEVAKTKAATNLPSIRKRKSIENEEEESKHNTSINDDGELDSDIDEEDESKFEKEFTVKKRQKKSPAKTQQQPQKSITTPTKPTPTKTTSKPTKPSATTSPSQQKQSSQSSQNTSKKQATSSSSQQSTQQKKKETKIKYNLKPINIERLATYDQHMSGTLSNEKIIKRLKKLDEYLQDKKRGNTEGLEIVLEVLIDPKFADNKIFEIRLMTSCCLSEIFRIYAPTLPFDMVVLKVVFKLFTEQVLQGDKVDKKLFPQYFQMLERLSVIKVFALLALVDSSMLTPFFKDCLSRVHGDKEHQPMDIMFSTLLNTILESLEEVPTSLWNELLESLIEREKGGVPTSKAIFTHDLIETNSRFLQVHFDLFLQDLLEPEILAGGQQQQQQDSSLSNNGISKQLKKKKNEILFEMFNILPEFIYPALQNLEFDLEDVNASIRKGAAIVLSRCYSTESASDELIAQRPTLYTTFLNRFHDVDIKIRTVMMEFSEHFTTTSDLEMERVLKSVRDRFRDSEPDIRIKAIQIFQKYIIKNPELMNPELMSEYLERVRDKDSKVRKDAEISLSTVWRSVREKYGPIDDWSNTLIDCFSTIPNTLIHCLGLYDDDKYRIEIAFDSILLPQHSDVKNRSQVFLEIYKYLDESNKQLFKKYLEEKKSLRQEFLALIQFLKNPKVVGGSTTPTSKKSQPPQQQQQQQQQQQQQLQQPENDIEVYITHVDNLLPKFIGESSKKLVRQLITPSNKKILDLLVLISDINTTFQEQYNIKISIISKAQNESSFSEFIKYMVNKLAYSIVGKENIKYLLRGLRSDLGLDNFDKNNPIDLLEEFNEKIYEKEVKDGVPETLEVLLMLSQVYANIFDDYGDQLVGFLTCSKSIVYPVLQILSNSWKTLKLSKKTLKSTLDMLLRLTQVPQPTLARLAFKTFIKFATPALTSINSTNGKVDNNKLVVTLKDLANNLFDQLEDKSKNLLSILEVIGCLAKGYSLVLSEHLDTLDILLIKKIMTGVCTLDFNQKVQLNKSVEHHLNTSYSKDVLIKIAAIKCMSNYLLGLREITKKSHEMVNMLFEFYIGLDKNKTYNDLEKSHLKIHIAIGLLRVFQRSQYEKEITPQQFILICNSTSITTKQRGDPLIRRLIEKLAKVMILNRLPMKYMAAFGMAAQQPYSVLALVRKHSTSIIKTRRMVISRLAASLSMAKNLTEFYPESSMPYFLYVVSHREDFERDAPDYIESACYLNFFIDLLVEEADNYSIIHTIFTKLKRSTDALDKKSKNHIIAAELGLQILTHQYQQKKWKPQKHPIVIVLPEKFYIIHDDQDEMSIDDEVTSIKLPSLLPKRFKLPPLPSITDQNNNNNNNNTNSTNNDESEKDENNNNKNDNDNDNDNDDNSTTAVPQKSIISKPPAKKVSKKAAAKQKSPKKKTNKKKKQSSSEEEVSSSEEEDESQDEEVEN", "length": 1450 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6TRW4-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "Pds5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQICWVKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEALVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNITVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDTKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTANVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSTEMDHSENEDYTMSSPLPGKKSDKREDSDLVRSELEKPRSRKKASVTDPEEKLGMDDLSKLVQEQKPKGSQRGRKRGHAASESEEQQWPEEKRHKEELLGNEDEQNSPPKKGKRGRPPKPLGGTSKEEPVVKTSKKGNKKKPAPPVVDEDEEEERQMGNTEQKSKSKQQRTSKRAQQRAESPETSAVESTQSTPQKGRGRPSKTPSPSQPKKNIRVGRSKQVATKENDSSEEMDVLQASSPVSDDTTQEGAEEEDISAGNVRRRSSKRERR", "length": 1447 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NTI5-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "PDS5B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYALQSAAGKDAAKQIAWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVKALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIRKQLEVLVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSIDGTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIEEDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTIGHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTTNVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELEKPRGRKKTPVTEQEEKLGMDDLTKLVQEQKPKGSQRSRKRGHTASESDEQQWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKKSGPPAPEEEEEEERQSGNTEQKSKSKQHRVSRRAQQRAESPESSAIESTQSTPQKGRGRPSKTPSPSQPKKNVRVGRSKQAATKENDSSEEVDVFQGSSPVDDIPQEETEEEEVSTVNVRRRSAKRERR", "length": 1447 }, "evidence": [ { "id": "F1N7G8", "url": "https://omabrowser.org/oma/group/F1N7G8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" }, { "name": "mitotic sister chromatid cohesion", "id": "GO:0007064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007064", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" }, { "name": "cohesin unloader activity", "id": "GO:0140670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140670", "evidence": [ { "database": "UniProtKB", "id": "F1N7G8", "url": "https://www.uniprot.org/uniprotkb/F1N7G8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1034, "end_pos": 1036, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1104, "end_pos": 1106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1157, "end_pos": 1159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1405, "end_pos": 1407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1034, "end_pos": 1036 }, { "start_pos": 1104, "end_pos": 1106 }, { "start_pos": 1157, "end_pos": 1159 }, { "start_pos": 1405, "end_pos": 1407 }, { "start_pos": 626, "end_pos": 628 }, { "start_pos": 842, "end_pos": 844 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5T0-1", "uniprot_ac": "F1N5T0", "uniprot_id": "F1N5T0_BOVIN", "mass": { "chemical_mass": 26330.0, "monoisotopic_mass": 26330.0 }, "refseq": {}, "gene_names": [ { "name": "CUTA", "type": "recommended", "evidence": [ { "id": "F1N5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ] } ], "protein_names": [ { "name": "Protein CutA", "type": "recommended", "evidence": [ { "id": "F1N5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5T0/entry#names_and_taxonomy" } ] }, { "name": "Brain acetylcholinesterase putative membrane anchor", "type": "synonym", "evidence": [ { "id": "F1N5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5T0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CUTA", "url": "https://www.uniprot.org/uniprotkb/F1N5T0", "locus": { "chromosome": "23", "start_pos": 7592055, "end_pos": 7593931, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001635", "url": "https://www.ensembl.org/id/ENSBTAG00000001635" } ] } } ], "crossref": [ { "id": "F1N5T0", "url": "https://alphafold.ebi.ac.uk/entry/F1N5T0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001635", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001635", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR004323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5T0", "url": "https://www.orthodb.org/?gene=F1N5T0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23419", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23419", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23419:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23419:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MZ77", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZ77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZ77-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZ77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5T0-1", "url": "https://www.uniprot.org/uniprotkb/F1N5T0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAPFPCTSADPGVDWLDPSSPLPPPEAGQTGPRGSKDWLALEVRVVRLLLSRGLRCFLITWLLPSIGCMRRGRAPTFLLGGGAALLLSLFWMPTLLPAASRLLLLPRALLSMASGSPPAQPSSASGSAYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNSPYLQWVRQVTESVPDSSTAPL", "length": 246, "header": "tr|F1N5T0-1|F1N5T0_BOVIN Isoform 1 of Protein CutA OS=Bos taurus OX=9913 GN=CUTA PE=3 SV=2 CANONICAL=F1N5T0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MZ77-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZ77/entry", "sequence": { "sequence": "MPTLLPAASRLLLLPRALLSMASGSPPAQPSSASGSAYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEPRCDEPCSCW", "length": 132, "header": "tr|A0A3Q1MZ77-1|F1N5T0_BOVIN Computationally mapped isoform of Protein CutA OS=Bos taurus OX=9913 GN=CUTA PE=3 SV=2 CANONICAL=F1N5T0-1" }, "locus": { "chromosome": "23", "start_pos": 7593117, "end_pos": 7592131, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083307.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083307.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061467.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061467.2" } ] } }, { "isoform_ac": "F1N5T0-1", "url": "https://www.uniprot.org/uniprotkb/F1N5T0/entry", "sequence": { "sequence": "MGAPFPCTSADPGVDWLDPSSPLPPPEAGQTGPRGSKDWLALEVRVVRLLLSRGLRCFLITWLLPSIGCMRRGRAPTFLLGGGAALLLSLFWMPTLLPAASRLLLLPRALLSMASGSPPAQPSSASGSAYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLVPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNSPYLQWVRQVTESVPDSSTAPL", "length": 246, "header": "tr|F1N5T0-1|F1N5T0_BOVIN Isoform 1 of Protein CutA OS=Bos taurus OX=9913 GN=CUTA PE=3 SV=2 CANONICAL=F1N5T0-1" }, "locus": { "chromosome": "23", "start_pos": 7593732, "end_pos": 7592151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002142.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002142.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002142.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002142.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "response to metal ion", "id": "GO:0010038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010038", "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "pmid": "" }, { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "F1N5T0", "url": "https://www.uniprot.org/uniprotkb/F1N5T0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5T0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5T0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5T0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1S5-1", "uniprot_ac": "F1N1S5", "uniprot_id": "F1N1S5_BOVIN", "mass": { "chemical_mass": 26289.0, "monoisotopic_mass": 26289.0 }, "refseq": {}, "gene_names": [ { "name": "EMCN", "type": "recommended", "evidence": [ { "id": "F1N1S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ] } ], "protein_names": [ { "name": "Endomucin", "type": "synonym", "evidence": [ { "id": "F1N1S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1S5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMCN", "url": "https://www.uniprot.org/uniprotkb/F1N1S5", "locus": { "chromosome": "6", "start_pos": 24332244, "end_pos": 24210613, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034206", "url": "https://www.ensembl.org/id/ENSBTAG00000034206" } ] } } ], "crossref": [ { "id": "F1N1S5", "url": "https://alphafold.ebi.ac.uk/entry/F1N1S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034206", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034206", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616367", "url": "https://www.ncbi.nlm.nih.gov/gene/616367", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N0Y0", "url": "https://www.orthodb.org/?gene=A0A3Q1N0Y0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1S5", "url": "https://www.orthodb.org/?gene=F1N1S5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15869:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15869:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N0Y0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1S5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1S5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLLQGTIFCLLLSSISSNDQIADTSATTTPLSTTSEINPTPPTRDTRTSPNGTSSKEAAQMPHLLTPSPVTPNTKGDGASTESIMETKLSTTEATVMSQSLSNAVSTSQSSDSKTETQSSIKATETPVNTSPPEASSFRTATLSSISVTSAENISPSQVGLENAKNASASTTSPSYSSIILPIVIALIVITLSVFVLVGLYRMCWKTDPGRMFSVSNRPQSDKESVKLLTVKTISHESGEHSAQGKTKN", "length": 250, "header": "tr|F1N1S5-1|F1N1S5_BOVIN Isoform 1 of Endomucin OS=Bos taurus OX=9913 GN=EMCN PE=4 SV=5 CANONICAL=F1N1S5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N0Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Y0/entry", "sequence": { "sequence": "MKLLQGTIFCLLLSSISSNDQIADTSATTTPLSTTSEINPTPPTRDTRTSPNDKNSTGELSIEGASTESIMETKLSTTEATVMSQSLSNAVSTSQSSDSKTETQSSIKATETPVNTSPPEASSFRTATLSSISVTSAENISPSQVGLENAKNASASTTSPSYSSIILPIVIALIVITLSVFVLVGLYRMCWKTDPGTQENGNEQPQSDKESVKLLTVKTISHESGEHSAQGKTKN", "length": 235, "header": "tr|A0A3Q1N0Y0-1|F1N1S5_BOVIN Computationally mapped isoform of Endomucin OS=Bos taurus OX=9913 GN=EMCN PE=4 SV=1 CANONICAL=F1N1S5-1" }, "locus": { "chromosome": "6", "start_pos": 24322989, "end_pos": 24210718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068808.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068808.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062504.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062504.1" } ] } }, { "isoform_ac": "F1N1S5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1S5/entry", "sequence": { "sequence": "MKLLQGTIFCLLLSSISSNDQIADTSATTTPLSTTSEINPTPPTRDTRTSPNGTSSKEAAQMPHLLTPSPVTPNTKGDGASTESIMETKLSTTEATVMSQSLSNAVSTSQSSDSKTETQSSIKATETPVNTSPPEASSFRTATLSSISVTSAENISPSQVGLENAKNASASTTSPSYSSIILPIVIALIVITLSVFVLVGLYRMCWKTDPGRMFSVSNRPQSDKESVKLLTVKTISHESGEHSAQGKTKN", "length": 250, "header": "tr|F1N1S5-1|F1N1S5_BOVIN Isoform 1 of Endomucin OS=Bos taurus OX=9913 GN=EMCN PE=4 SV=5 CANONICAL=F1N1S5-1" }, "locus": { "chromosome": "6", "start_pos": 24322989, "end_pos": 24210718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048484.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048484.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045511.6", "url": "https://www.ensembl.org/id/ENSBTAP00000045511.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ], "pmid": "" }, { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F1N1S5", "url": "https://www.uniprot.org/uniprotkb/F1N1S5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1S5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 250, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1S5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1S5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N444-1", "uniprot_ac": "F1N444", "uniprot_id": "F1N444_BOVIN", "mass": { "chemical_mass": 185540.0, "monoisotopic_mass": 185540.0 }, "refseq": { "ac": "XP_024854254", "name": "latent-transforming growth factor beta-binding protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854254" }, "gene_names": [ { "name": "LTBP1", "type": "recommended", "evidence": [ { "id": "F1N444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ] }, { "name": "LTBP1", "type": "synonym", "evidence": [ { "id": "XP_024854254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854254" } ] } ], "protein_names": [ { "name": "Latent-transforming growth factor beta-binding protein 1", "type": "recommended", "evidence": [ { "id": "F1N444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N444/entry#names_and_taxonomy" } ] }, { "name": "Transforming growth factor beta-1-binding protein 1", "type": "synonym", "evidence": [ { "id": "F1N444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N444/entry#names_and_taxonomy" } ] }, { "name": "latent-transforming growth factor beta-binding protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024854254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854254" } ] } ], "function": [ { "annotation": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LF45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF45#function" }, { "database": "UniProtKB", "id": "ARBA00059743", "url": "https://www.uniprot.org/uniprotkb/ARBA00059743#function" }, { "database": "UniProtKB", "id": "F1MJM5", "url": "https://www.uniprot.org/uniprotkb/F1MJM5#function" }, { "database": "UniProtKB", "id": "A0A3Q1N2U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U0#function" }, { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LTBP1", "url": "https://www.uniprot.org/uniprotkb/F1N444", "locus": { "chromosome": "11", "start_pos": 15930106, "end_pos": 15473810, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019839", "url": "https://www.ensembl.org/id/ENSBTAG00000019839" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019839", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510559", "url": "https://www.ncbi.nlm.nih.gov/gene/510559", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SQRCTKX", "url": "https://omabrowser.org/oma/group/SQRCTKX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N444", "url": "https://www.orthodb.org/?gene=F1N444", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47333:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47333:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47333:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47333:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00683", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00683", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2129379", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2129379", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173789", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173789", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024854254", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854254", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF45-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2U0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJM5", "url": "https://www.uniprot.org/uniprotkb/F1MJM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJM5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N444-1", "url": "https://www.uniprot.org/uniprotkb/F1N444-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAWLRWGLLLWAGLLASSAHGRVRRITYVVRPGPGLAAGALPLGGPPRPRTFNVALNARYSRSSAGAGAPSERTRRTSPPGGAALQGLRPPPPPPELARPGGPGGPLHPKPGGHPAAAPFAKQGRQAMRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGQCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETTAAQDTSSPVFGGQSTAAASSWVPPEQAAKRTSSKKADALPRVSPVAQMTLTLKPKPSVGLSQQIHSQMTPLSSQNVMIHHGQTQEYVLKPTYFTAQKVVSGEQSTEGSLPLRFGQDHVPAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASLPKVYQHSQQSGKALGTHVVHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRVDGPTGQKVKEAQPGQSQAPYQGLPVQKTQTVHSSYQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFHKCQKCPKKPSYHGYNQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKVGFGPDPTFSSCVPDTPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREQGPGAVEPEVATVPPEKEIPSLDQEKTRLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPMPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYDGYKFNEQQRKCVDIDECAQDQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTMGAFRCEYCDSGYHMTPGGQCEDVDECLTPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPKICTNGTCSNLEGSYMCSCHKGYSPTPDHKHCEDIDECQQGTMCMNGQCKNTDGSFRCTCGQGYQLSAAKDQCEDIDECQHHHLCSNGQCRNTEGSFRCVCDHGYRASALGDHCEDINECLEDKSVCQGGDCINTKGSYECTCPDGFQLNDNKGCQDINECEQPGLCGPHGECLNTDSSFHCICEQGFSISADGRTCEDIDECVNNTICDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADESQEYSPMTGQCRSRLSMDSEVDEPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVPGTAEFTEMCPRGKGFVPSEESSYGVDGENYKDADECLLFGQEICKNGFCMNTQPGYECYCKQGTYYDPVKLQCFDIDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDASEKRCIRPTESHEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYAPEADPYFVRDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECDELNNRMSLCKNAKCINTEGSYKCVCLPGFVPSDKPNYCTPLNTALNLEKDSDLE", "length": 1708, "header": "tr|F1N444-1|F1N444_BOVIN Isoform 1 of Latent-transforming growth factor beta-binding protein 1 OS=Bos taurus OX=9913 GN=LTBP1 PE=3 SV=3 CANONICAL=F1N444-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LF45-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF45/entry", "sequence": { "sequence": "MAGAWLRWGLLLWAGLLASSAHGRVRRITYVVRPGPGLAAGALPLGGPPRPRTFNVALNARYSRSSAGAGAPSERTRRTSPPGGAALQGLRPPPPPPELARPGGPGGPLHPKPGGHPAAAPFAKQGRQAMRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGQCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETTAAQDTSSPVFGGQSTAAASSWVPPEQAAKRTSSKKADALPRVSPVAQMTLTLKPKPSVGLSQQIHSQMTPLSSQNVMIHHGQTQEYVLKPTYFTAQKVVSGEQSTEGSLPLRFGQDHVPAPFQLICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASLPKVYQHSQQSGKALGTHVVHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRVDGPTGQKVKEAQPGQSQAPYQGLPVQKTQTVHSSYQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFHKCQKCPKKPSYHGYNQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKVGFGPDPTFSSCVPDTPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAKEEPVEALTFSREQGPGAVEPEVATVPPEKEIPSLDQEKTRLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPMPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYDGYKFNEQQRKCVDIDECAQDQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTMGAFRCEYCDSGYHMTPGGQCEDVDECLTPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPKICTNGTCSNLEGSYMCSCHKGYSPTPDHKHCEDIDECQQGTMCMNGQCKNTDGSFRCTCGQGYQLSAAKDQCEDIDECQHHHLCSNGQCRNTEGSFRCVCDHGYRASALGDHCEDINECLEDKSVCQGGDCINTKGSYECTCPDGFQLNDNKGCQDINECEQPGLCGPHGECLNTDSSFHCICEQGFSISADGRTCEDIDECVNNTICDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADESQEYSPMTGQCRSRLSMDSEVDEPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVPGTAEFTEMCPRGKGFVPSEESSYGVDGENYKDADECLLFGQEICKNGFCMNTQPGYECYCKQGTYYDPVKLQCFDIDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDASEKRCIRPTESHEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYAPEADPYFVRDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECDELNNRMSLCKNAKCINTEGSYKCVCLPGFVPSDKPNYCTPLNTALNLEKDSDLE", "length": 1599, "header": "tr|A0A3Q1LF45-1|A0A3Q1LF45_BOVIN Computationally mapped isoform of Latent-transforming growth factor beta-binding protein 1 OS=Bos taurus OX=9913 GN=LTBP1 PE=4 SV=2 CANONICAL=F1N444-1" }, "locus": { "chromosome": "11", "start_pos": 15929300, "end_pos": 15474009, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085972.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085972.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056685.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056685.2" } ] } }, { "isoform_ac": "A0A3Q1N2U0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U0/entry", "sequence": { "sequence": "MDQSHPECLLKHRLLDSTWLRQDTRTCMSASCVPPCQNGGMCLRPQLCVCKPGTKGKACETTAAQDTSSPVFGGQSTAAASSWVPPEQAAKRTSSKKADALPRVSPVAQMTLTLKPKPSVGLSQQIHSQMTPLSSQNVMIHHGQTQEYVLKPTYFTAQKVVSGEQSTEGSLPLRFGQDHVPAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASLPKVYQHSQQSGKALGTHVVHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRVDGPTGQKVKEAQPGQSQAPYQGLPVQKTQTVHSSYQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFHKCQKCPKKPSYHGYNQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKVGFGPDPTFSSCVPDTPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREQGPGAVEPEVATVPPEKEIPSLDQEKTRLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPMPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYDGYKFNEQQRKCVDIDECAQDQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTMGAFRCEYCDSGYHMTPGGQCEDVDECLTPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPKICTNGTCSNLEGSYMCSCHKGYSPTPDHKHCEDIDECQQGTMCMNGQCKNTDGSFRCTCGQGYQLSAAKDQCEDIDECQHHHLCSNGQCRNTEGSFRCVCDHGYRASALGDHCEDINECLEDKSVCQGGDCINTKGSYECTCPDGFQLNDNKGCQDINECEQPGLCGPHGECLNTDSSFHCICEQGFSISADGRTCEDIDECVNNTICDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADESQEYSPMTGQCRSRLSMDSEVDEPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVPGTAEFTEMCPRGKGFVPSEESSYGVDGENYKDADECLLFGQEICKNGFCMNTQPGYECYCKQGTYYDPVKLQCFDIDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDASEKRCIRPTESHEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYAPEADPYFVRDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECDELNNRMSLCKNAKCINTEGSYKCVCLPGFVPSDKPNYCTPLNTALNLEKDSDLE", "length": 1558, "header": "tr|A0A3Q1N2U0-1|F1N444_BOVIN Computationally mapped isoform of Latent-transforming growth factor beta-binding protein 1 OS=Bos taurus OX=9913 GN=LTBP1 PE=3 SV=2 CANONICAL=F1N444-1" }, "locus": { "chromosome": "11", "start_pos": 15929300, "end_pos": 15504217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074954.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074954.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063636.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063636.2" } ] } }, { "isoform_ac": "F1MJM5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJM5/entry", "sequence": { "sequence": "MAGAWLRWGLLLWAGLLASSAHGRVRRITYVVRPGPGLAAGALPLGGPPRPRTFNVALNARYSRSSAGAGAPSERTRRTSPPGGAALQGLRPPPPPPELARPGGPGGPLHPKPGGHPAAAPFAKQGRQAMRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGQCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETTAAQDTSSPVFGGQSTAAASSWVPPEQAAKRTSSKKADALPRVSPVAQMTLTLKPKPSVGLSQQIHSQMTPLSSQNVMIHHGQTQEYVLKPTYFTAQKVVSGEQSTEGSLPLRFGQDHVPAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASLPKVYQHSQQSGKALGTHVVHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRVDGPTGQKVKEAQPGQSQAPYQGLPVQKTQTVHSSYQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFHKCQKCPKKPSYHGYNQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKVGFGPDPTFSSCVPDTPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAKEEPVEALTFSREQGPGAVEPEVATVPPEKEIPSLDQEKTRLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPMPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYDGYKFNEQQRKCVDIDECAQDQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTMGAFRCEYCDSGYHMTPGGQCEDVDECLTPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPKICTNGTCSNLEGSYMCSCHKGYSPTPDHKHCEDIDECQQGTMCMNGQCKNTDGSFRCTCGQGYQLSAAKDQCEDIDECQHHHLCSNGQCRNTEGSFRCVCDHGYRASALGDHCEDINECLEDKSVCQGGDCINTKGSYECTCPDGFQLNDNKGCQDINECEQPGLCGPHGECLNTDSSFHCICEQGFSISADGRTCEDVNECELLSGVCGEAFCENVEGSFLCVCADESQEYSPMTGQCRSRLSMDSEVDEPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVPGTAEFTEMCPRGKGFVPSEESSYGVDGENYKDADECLLFGQEICKNGFCMNTQPGYECYCKQGTYYDPVKLQCFDIDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDASEKRCIRPTESHEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYAPEADPYFVRDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECDELNNRMSLCKNAKCINTEGSYKCVCLPGFVPSDKPNYCTPLNTALNLEKDSDLE", "length": 1613, "header": "tr|F1MJM5-1|F1MJM5_BOVIN Computationally mapped isoform of Latent-transforming growth factor beta-binding protein 1 OS=Bos taurus OX=9913 GN=LTBP1 PE=4 SV=4 CANONICAL=F1N444-1" }, "locus": { "chromosome": "11", "start_pos": 15929300, "end_pos": 15474009, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055559.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055559.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049409.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049409.4" } ] } }, { "isoform_ac": "F1N444-1", "url": "https://www.uniprot.org/uniprotkb/F1N444/entry", "sequence": { "sequence": "MAGAWLRWGLLLWAGLLASSAHGRVRRITYVVRPGPGLAAGALPLGGPPRPRTFNVALNARYSRSSAGAGAPSERTRRTSPPGGAALQGLRPPPPPPELARPGGPGGPLHPKPGGHPAAAPFAKQGRQAMRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGQCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETTAAQDTSSPVFGGQSTAAASSWVPPEQAAKRTSSKKADALPRVSPVAQMTLTLKPKPSVGLSQQIHSQMTPLSSQNVMIHHGQTQEYVLKPTYFTAQKVVSGEQSTEGSLPLRFGQDHVPAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASLPKVYQHSQQSGKALGTHVVHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRVDGPTGQKVKEAQPGQSQAPYQGLPVQKTQTVHSSYQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFHKCQKCPKKPSYHGYNQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKVGFGPDPTFSSCVPDTPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREQGPGAVEPEVATVPPEKEIPSLDQEKTRLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPMPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYDGYKFNEQQRKCVDIDECAQDQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTMGAFRCEYCDSGYHMTPGGQCEDVDECLTPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPKICTNGTCSNLEGSYMCSCHKGYSPTPDHKHCEDIDECQQGTMCMNGQCKNTDGSFRCTCGQGYQLSAAKDQCEDIDECQHHHLCSNGQCRNTEGSFRCVCDHGYRASALGDHCEDINECLEDKSVCQGGDCINTKGSYECTCPDGFQLNDNKGCQDINECEQPGLCGPHGECLNTDSSFHCICEQGFSISADGRTCEDIDECVNNTICDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADESQEYSPMTGQCRSRLSMDSEVDEPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVPGTAEFTEMCPRGKGFVPSEESSYGVDGENYKDADECLLFGQEICKNGFCMNTQPGYECYCKQGTYYDPVKLQCFDIDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDASEKRCIRPTESHEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYAPEADPYFVRDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECDELNNRMSLCKNAKCINTEGSYKCVCLPGFVPSDKPNYCTPLNTALNLEKDSDLE", "length": 1708, "header": "tr|F1N444-1|F1N444_BOVIN Isoform 1 of Latent-transforming growth factor beta-binding protein 1 OS=Bos taurus OX=9913 GN=LTBP1 PE=3 SV=3 CANONICAL=F1N444-1" }, "locus": { "chromosome": "11", "start_pos": 15929300, "end_pos": 15474009, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026435.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026435.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026435.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026435.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1060, "start_aa": "Thr", "end_pos": 1060, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1060", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2129379", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2129379", "resource": "Reactome", "description": "Molecules associated with elastic fibres" }, { "id": "R-BTA-2173789", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173789", "resource": "Reactome", "description": "TGF-beta receptor signaling activates SMADs" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XPE8-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARIGWGFLLCAWALLSPALAAAEKGRLRRITYVLHPGQAGSAAGRQQQRPALLAGQQQQRTFNVQLNARYGTAERTRRMSKAGGAGVQLRLGPVGQSHSNSAASFSKPARFGPRPKPPPGPHGNSSGAPPRQKHPLPPLPGVNVCGGQCCHGWSRATGSQRCIKPNCAPPCQNGGMCLRPQLCVCKPGTKGNSCEDTVMQDTSSTGGRSPVVPPWPIPQQAAQQAFSQKVQVPPKVGPMTQMAFTIKQKPPVGLPQQMQPQMIPLSSQTLMMNLHHGQTQEYVIKPKYYPVKKVISGEQSTEGSLPLRLGQDQLASSFQLGNHTGRIKVVFTPSICKVTCTKGNCQNNCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNYTGKLCQIPVQNGNTPKLYHHPQQVNKAVGSQIIHSTHTLPLTMSGQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDSASTGQKSKVPQPGHPQVSYQGLPYQKTQKGHATYTNQQPIPHVFPVSVKTQLGRCFQETIGTQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYSPMTECPQGYKRINATFCQDINECQLQGVCPNGECLNTMGSYRCTCKMGFVPDPTLSRCIADSPIVAEEKGPCYRFVSAGKQCMHPLSVQLSKQLCCCSVGKAWGPNCEKCPLPGTAAFKEICPGGMGYTVSGPHRNKLYHHPAVRVQPPVIGKTPITQPVAKGTSPPPLPAKEEPVEALTFSQKSEPDMAVQEVATAAPDQELVSLDQEKQILEPGQPQLSPGISTINLHPQFPVVIEKTSPPLPVEVAPEVSTSSASQVIAPTQVTEINECTVNPDICGAGHCVNLPVGYTCICYEGYRLNDQQTKCSDINECNQTPHLCSLGRCENTEGSFLCICQAGFMASEDGTDCIDFDECSRPHTCGEGFCINTVGSYRCEYCDSGYQMNRRGECEDIDECTTPTTCPDAQCINAPGSYQCIPCRVGFRGWNGQCHDINECQYGNLCANGRCENIEGSFRCICGQGFKLSASEDQCEDIDECQDRSLCVNGRCRNTEGSFRCVCSQGYVLSATGDQCEDIDECLQDSDICLGGNCMNTDGSYKCSCLDGFQQIANRGCQDINECERSDLCSPHGECLNTDGSYQCICEQGFSVSADGRTCEDIDECVNGTVCGSHGFCENMDGSYRCLCYQGYQDSQDGQGCTDVNECEMLSGVCGEALCENVDGSFLCLCSDENQEYDPMTGQCRFRTSSELPIEPDQHEDGKKECYYNLNDANFCDNVLASNVTKQECCCTLGAGWGDNCEIFPCPVFGTAEFTDLCPEGKGFIPSGESSYGLLAENYKDADECQLFGQEICKNGFCLNTQPGYECYCKQGTYYDPVKLQCFDTDECQDPNSCIDGQCINTEGSYNCFCTHPMVLDATEKRCIRPADSSEQTEETEVYQDLCWQHLSDDFVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKESEDYAQLCNIPVPGSRRPYGQDALVDFEEHYTPETNPYFVEDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECNELNNRMSLCKNAKCINTEGSYKCLCLPGYVPSDKPNYCTPLNSELDSELE", "length": 1655 }, "evidence": [ { "id": "F1N444", "url": "https://omabrowser.org/oma/group/F1N444/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIHHGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE", "length": 1721 }, "evidence": [ { "id": "F1N444", "url": "https://omabrowser.org/oma/group/F1N444/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CG19-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "Ltbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGAWLRWGLLLWAGLLAWSAHGRVRRITYVVRPGPGLPAGALPLAGPPRTFNVALDARYSRSSTAASSRALAGPPAERTRRTSQPGGAALPGLRSPLPPEPARPGGPSRQLHSKAGAQTAVTRFAKHGRQVVRSQVQQDAQSAGGSRLQVQQKQQLQGINVCGGQCCHGWSKPPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGSKGKACEITAAQDTMPPAFGGQNPGSSWAPLEQAAKHTSTKKADTLPRVSPVAQMTLTLKPKPSMGLSQQIHPQVAPLSSQNVMIRHGQTQEYLLKPKYFPAPKVVSAEQSTEGSFSLRYGQEQGTAPFQVSNHTGRIKVVFTPSICKVTCTKGNCQNSCQKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVLGASMPKLYQHAQQQGKALGSHVIHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDSPGGQKVKEAQPGQSQVSYQGLPVQKTQTVHSTYSHQQLIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPVISEEKGPCYRLVSPGRHCMHPLSVHLTKQICCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHQHIGKEAVYVKPKNTQPVAKSTHPPPLPAKEEPVEALTSSWEHGPRGAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQLRKCVDIDECAQVRHLCSQGRCENTEGSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSFRCTCGQGYQLSAAKDQCEDIDECEHHHLCSHGQCRNTEGSFQCVCNQGYRASVLGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGFQLNDNKGCQDINECAQPGLCGSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRVTEDSGVDRQPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGEEICKNGYCLNTQPGYECYCKQGTYYDPVKLQCFDMDECQDPNSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSYKCLCLPGYIPSDKPNYCTPLNSALNLDKESDLE", "length": 1712 }, "evidence": [ { "id": "F1N444", "url": "https://omabrowser.org/oma/group/F1N444/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "growth factor binding", "id": "GO:0019838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019838", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "transforming growth factor beta binding", "id": "GO:0050431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050431", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "microfibril binding", "id": "GO:0050436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050436", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "receptor ligand inhibitor activity", "id": "GO:0141069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141069", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sequestering of TGFbeta in extracellular matrix", "id": "GO:0035583", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035583", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "establishment of protein localization to extracellular region", "id": "GO:0035592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035592", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "microfibril", "id": "GO:0001527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001527", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N444", "url": "https://www.uniprot.org/uniprotkb/F1N444" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1239, "end_pos": 1241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1353, "end_pos": 1355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N444" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 178, "end_pos": 210, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N444" }, { "id": "PS51364", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51364" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TB", "eco_id": "ECO_0000259", "start_pos": 546, "end_pos": 591, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1060 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 1239, "end_pos": 1241 }, { "start_pos": 1353, "end_pos": 1355 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 609, "end_pos": 611 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3C5-1", "uniprot_ac": "F1N3C5", "uniprot_id": "F1N3C5_BOVIN", "mass": { "chemical_mass": 89818.0, "monoisotopic_mass": 89818.0 }, "refseq": { "ac": "NP_001192418", "name": "TBC1 domain family member 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192418" }, "gene_names": [ { "name": "TBC1D5", "type": "recommended", "evidence": [ { "id": "F1N3C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ] }, { "name": "TBC1D5", "type": "synonym", "evidence": [ { "id": "NP_001192418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192418" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 5", "type": "recommended", "evidence": [ { "id": "F1N3C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3C5/entry#names_and_taxonomy" } ] }, { "name": "TBC1 domain family member 5", "type": "synonym", "evidence": [ { "id": "NP_001192418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192418" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5", "locus": { "chromosome": "1", "start_pos": 154095127, "end_pos": 154616588, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030581", "url": "https://www.ensembl.org/id/ENSBTAG00000030581" } ] } } ], "crossref": [ { "id": "F1N3C5", "url": "https://alphafold.ebi.ac.uk/entry/F1N3C5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030581", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030581", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614554", "url": "https://www.ncbi.nlm.nih.gov/gene/614554", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614554", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614554", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PWNQYFQ", "url": "https://omabrowser.org/oma/group/PWNQYFQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N488", "url": "https://www.orthodb.org/?gene=A0A3Q1N488", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKZ2", "url": "https://www.orthodb.org/?gene=A0A3Q1NKZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N3C5", "url": "https://www.orthodb.org/?gene=F1N3C5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957:SF337", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957:SF337", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192418", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N488", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N488", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N488-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N488-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3C5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3C5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGTDPLSSYPDQPGGDSNQNGRTSSLDSDGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSVKEIHITNPRKAVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQESVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLTLTLVDYVFVAMLLYIRDALISSNYQTCLGLLMHYPLIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGVPLNINKVSNSLINFGRKLISPAAAPGGAGGPVAAGGAGAPSPAAAPTRTLAEAPRHALQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQTLTDLPGQSSKNISSSPSIESLPGGREFTGSPPSSAAKKDSFFSNISRSRSHSKTMGRRESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQEVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEDNEQISISDDHYCSSGAAQQVPGSQGGAGPGGVHRGRGETPGRRERPGADDFVLVSKDCEERGAGLSPAGQAQPLRPLRGAARPVLVFSDPLTGPASASSSNPSSSPDDDSSGHSKDSGFTIVSPLDL", "length": 809, "header": "tr|F1N3C5-1|F1N3C5_BOVIN Isoform 1 of TBC1 domain family member 5 OS=Bos taurus OX=9913 GN=TBC1D5 PE=4 SV=3 CANONICAL=F1N3C5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N488-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N488/entry", "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGTDPLSSYPDQPGGDSNQNGRTSSLDSDGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSVKEIHITNPRKAVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQESVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLTLTLVDYVFVAMLLYIRDALISSNYQTCLGLLMHYPLIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGVPLNINKVSNSLINFGRKLISPAAAPGGAGGPVAAGGAGAPSPAAAPTRTLAEAPRHALQQQQQRLMKSESMPVQLNKGQSSKNISSSPSIESLPGGREFTGSPPSSAAKKDSFFSNISRSRSHSKTMGRRESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQEVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEDNEQISISDDHYCSSGAAQQAPPAAPGRRERPGADDFVLVSKDCEERGAGLSPAGQAQPLRPLRGAARPVLVFSDPLTGPASASSSNPSSSPDDDSSGHSKDSGFTIVSPLDL", "length": 772, "header": "tr|A0A3Q1N488-1|F1N3C5_BOVIN Computationally mapped isoform of TBC1 domain family member 5 OS=Bos taurus OX=9913 GN=TBC1D5 PE=4 SV=1 CANONICAL=F1N3C5-1" }, "locus": { "chromosome": "1", "start_pos": 154451667, "end_pos": 154096131, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083881.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083881.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064561.1" } ] } }, { "isoform_ac": "A0A3Q1NKZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKZ2/entry", "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGTDPLSSYPDQPGGDSNQNGRTSSLDSDGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKHITNPRKAVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQESVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLTLTLVDYVFVAMLLYIRDALISSNYQTCLGLLMHYPLIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGVPLNINKVSNSLINFGRKLISPAAAPGGAGGPVAAGGAGAPSPAAAPTRTLAEAPRHALQQQQQRLMKSESMPVQLNKGQSSKNISSSPSIESLPGGREFTGSPPSSAAKKDSFFSNISRSRSHSKTMGRRESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQEVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEDNEQISISDDHYCSSGAAQQAPPAAPGRRERPGADDFVLVSKDCEERGAGLSPAGQAQPLRPLRGAARPVLVFSDPLTGPASASSSNPSSSPDDDSSGHSKDSGFTIVSPLDL", "length": 742, "header": "tr|A0A3Q1NKZ2-1|F1N3C5_BOVIN Computationally mapped isoform of TBC1 domain family member 5 OS=Bos taurus OX=9913 GN=TBC1D5 PE=4 SV=2 CANONICAL=F1N3C5-1" }, "locus": { "chromosome": "1", "start_pos": 154451667, "end_pos": 154096131, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074279.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074279.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073051.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073051.2" } ] } }, { "isoform_ac": "F1N3C5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3C5/entry", "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGTDPLSSYPDQPGGDSNQNGRTSSLDSDGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSVKEIHITNPRKAVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQESVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLTLTLVDYVFVAMLLYIRDALISSNYQTCLGLLMHYPLIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGVPLNINKVSNSLINFGRKLISPAAAPGGAGGPVAAGGAGAPSPAAAPTRTLAEAPRHALQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQTLTDLPGQSSKNISSSPSIESLPGGREFTGSPPSSAAKKDSFFSNISRSRSHSKTMGRRESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQEVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEDNEQISISDDHYCSSGAAQQVPGSQGGAGPGGVHRGRGETPGRRERPGADDFVLVSKDCEERGAGLSPAGQAQPLRPLRGAARPVLVFSDPLTGPASASSSNPSSSPDDDSSGHSKDSGFTIVSPLDL", "length": 809, "header": "tr|F1N3C5-1|F1N3C5_BOVIN Isoform 1 of TBC1 domain family member 5 OS=Bos taurus OX=9913 GN=TBC1D5 PE=4 SV=3 CANONICAL=F1N3C5-1" }, "locus": { "chromosome": "1", "start_pos": 154451667, "end_pos": 154096131, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043194.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043194.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040783.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040783.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614554", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614554", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K712-1", "protein_name": "TBC1 domain family member 5", "gene_name": "Tbc1d5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKPRGDSCQNGRGANSNLDCDGTFSSYMREWDDLFVNNNYLAAVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIKELRSWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVRRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDTELYMHLNRLEIPPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLHLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPLIGDIHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLIAPASAPGSMGGPVPGSNSSSSFSAAVPFRTSAEAPRHHSQQQRQQQQQQQQQQQQQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQALTDLQGQSPKTISSSPSMESLPGGREPPGSPPSSATKRDSFFSHIARSRSHSKAMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSSGQDQGTQGPRAAKQASSEMPGCTGGATSDDFILVSKEDEGRRAKEAFSGQAQPLLTLRNTSGKSRVPTCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 827 }, "evidence": [ { "id": "F1N3C5", "url": "https://omabrowser.org/oma/group/F1N3C5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0X5W4-1", "protein_name": "TBC1 domain family member 5", "gene_name": "TBC1D5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVTSKTSEGLQKIVREPPRRLLQYYKYPSVEIIANMYHSVSETSHPLQTEEQEVGIDPLQSYLNKTEEGGSNENGSTQHTSDSAGTFISYSKEWEELFVNNNYLATIRLKGINGQLRSSRFRSVCWKLFLEVLPQDRSQWIKNTSELRTSYNKIKEIHITNPRKAGQQDLIINNPLSQDEGSLWNKFFQDKELRAMIEQDVTRTFPEMQYFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFILHCDHQAFSHASEAAQPSEEMKVLLNPEYLEHDAYAMFTRLMKTAEHWFSTFEHDSQKEKDVMITPMPFARPQDLGPSIAIVTKVNQIQDQLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSITLNLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPPIGDVHSLILRALFLRDPKKNPRPVTHQFQQNLDYYKARGADLMNKTRASAKAAPLNINKVSNSLLNFGRKLIAPAMASGSTAGPTAGTGSFPPTTGPTRGTTEAPQYHQHQAQQQRMMKSESMPVQLGKGQSSKISSSPSIESLPGGREFTGSPPLSASKKDSFFSTISRSRSQSKTMSRKESEEELEAQISFLQGQLNDLEAMCKYCAKMMNTHLGNIQEVILQEHLEKEDEILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADDHYCSNNQNKGTGDILKGSVMTKQQFISGRQTATHSSTSESKGADDCILVSKEEGSRNAVPEPAQLLQTFKESAVKPEAPSRPLVFSDPLMGSISASSSNLSSSPDDNSSNNSKDSDFAIVSPLDI", "length": 828 }, "evidence": [ { "id": "F1N3C5", "url": "https://omabrowser.org/oma/group/F1N3C5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QXM3-1", "protein_name": "TBC1 domain family member 5", "gene_name": "tbc1d5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQHPNFETRHPLQQDEQETGYDPLQNYNRNRDRGSLGSAVESTLQSYRKEWDDLFQNSNYLPRIRQAGINGRLRSSRFRSVCWKLYLDVLPEDKAQWISRTKEHRAQYEKIKEMHITNPRKAAGQQDLVVNNPLSQDEGSLWNKFFQDKELRGMIKQDVLRTFPEMLYFQEEDVRTKMTDILFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFQHASETANPSDEMKVLLDPKFHEHDAYTMFSLLMETAEPWFSSFEREVRKGKEEMLTSIPFARPQDSGPSVAIVTKVNRIQDQLIKKHDIELYMHLNRLEIAPQIYGIRWVRLLFGREFPLQDLLVVWDALFADSITLDLVDYVFVAMLLYIRDALIASNFQTCLGLLMHYPPIGDIHSLLLKALFLRDPKNNPRPVNYQFQQNLDYYKTRGADLVNKTRASTKAAPLNINKVSSSLLNFGRKLIAPMGGGSGGISPINSEVLSAPPLPAPASRPLTEAPSCPAPLNTQMKSQPLPQTQHQHRLLKSESMPVHLSKDVGSCGASQISLPAQIHSDITGHSSRTVSSSPSTESLSCSRDHAMSSPPLPVSRGRDSSTSSPPSSATKKDSFFNISRSRSHSKTINKKDAEELEAQVSFLQGQINDLEAMSKYCAKMMNAHIGKIQDVILQEHLEKEDEVLVSLAGLKQIKDILKGALRFNQSQLESEDNEEITIADDHYCSSQYSTLKYYSDFVHQSADNDADADASRQQTQQLDDHEEVDGMADKEEELQEVEEKVLTTKNVPMTPELQASEGRNWDDYILVSKDGEPSGNEEQSGTPTAPLFKNVRALNKADFQDPLMGTTSGSSSPDDGSTHSKDSDFTIVNPTDL", "length": 863 }, "evidence": [ { "id": "F1N3C5", "url": "https://omabrowser.org/oma/group/F1N3C5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80XQ2-1", "protein_name": "TBC1 domain family member 5", "gene_name": "Tbc1d5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNSTLDTEGTFNSYMKEWEELFVNNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRPATYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTISSSPSIESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAGENEQITIADDHYCSSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKEDEGHRARGAFSGQAQPLLTLRSTSGKSRAPACSPLLFSDPLMGPASASASSSNPSSSPDDDSSKESGFTIVSPLDI", "length": 815 }, "evidence": [ { "id": "F1N3C5", "url": "https://omabrowser.org/oma/group/F1N3C5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92609-1", "protein_name": "TBC1 domain family member 5", "gene_name": "TBC1D5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI", "length": 795 }, "evidence": [ { "id": "F1N3C5", "url": "https://omabrowser.org/oma/group/F1N3C5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "AP-2 adaptor complex binding", "id": "GO:0035612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035612", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "retromer complex binding", "id": "GO:1905394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905394", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "positive regulation of receptor internalization", "id": "GO:0002092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002092", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "AP-2 adaptor complex", "id": "GO:0030122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030122", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "Atg1/ULK1 kinase complex", "id": "GO:1990316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990316", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "F1N3C5", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3C5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 809, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3C5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3C5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3C5" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 79, "end_pos": 357, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 439, "end_pos": 441 }, { "start_pos": 553, "end_pos": 555 }, { "start_pos": 586, "end_pos": 588 }, { "start_pos": 674, "end_pos": 676 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1R6-1", "uniprot_ac": "F1N1R6", "uniprot_id": "F1N1R6_BOVIN", "mass": { "chemical_mass": 41789.0, "monoisotopic_mass": 41789.0 }, "refseq": {}, "gene_names": [ { "name": "PDGFRL", "type": "recommended", "evidence": [ { "id": "F1N1R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R6" } ] } ], "protein_names": [ { "name": "Platelet-derived growth factor receptor-like protein", "type": "recommended", "evidence": [ { "id": "F1N1R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1R6", "url": "https://www.uniprot.org/uniprotkb/F1N1R6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDGFRL", "url": "https://www.uniprot.org/uniprotkb/F1N1R6", "locus": { "chromosome": "27", "start_pos": 19631336, "end_pos": 19709829, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001966", "url": "https://www.ensembl.org/id/ENSBTAG00000001966" } ] } } ], "crossref": [ { "id": "F1N1R6", "url": "https://alphafold.ebi.ac.uk/entry/F1N1R6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001966", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001966", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CWGQLCN", "url": "https://omabrowser.org/oma/group/CWGQLCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N8R2", "url": "https://www.orthodb.org/?gene=A0A3Q1N8R2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1R6", "url": "https://www.orthodb.org/?gene=F1N1R6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15360", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15360", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15360:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15360:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N8R2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N8R2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8R2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R6", "url": "https://www.uniprot.org/uniprotkb/F1N1R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIWLLLGLLLMHEALEDVTGQHPPKNKRPKEPGENRIKPTNKKVKPKIPKIKDRDSADPTPKTPSIMTQMMDKGRFQKPAATLSLVAGQTLELRCKGNKIGWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCTGYVCRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDLKRGFVYLQPHVGHQGVVYCKAEAGGKSQISVKYQLLYAEVPRGPPSTTILASSNKVKGGDDVSVLCTVLGEPDVEVEFRWTYPGQKDERPVTIQDSWRLIHRGLGHTTRISQSVLSIEDFETIDAGYYICTAQNLQGQTTVATTVESS", "length": 375, "header": "tr|F1N1R6-1|F1N1R6_BOVIN Isoform 1 of Platelet-derived growth factor receptor-like protein OS=Bos taurus OX=9913 GN=PDGFRL PE=4 SV=1 CANONICAL=F1N1R6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N8R2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8R2/entry", "sequence": { "sequence": "QGKAVLLGSVITGQHPPKNKRPKEPGENRIKPTNKKVKPKIPKIKDRDSADPTPKTPSIMTQMMDKGRFQKPAATLSLVAGQTLELRCKGNKIGWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCTGYVCRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDLKRGFVYLQPHVGHQGVVYCKAEAGGKSQISVKYQLLYAEVPRGPPSTTILASSNKVKGGDDVSVLCTVLGEPDVEVEFRWTYPGQKDERPVTIQDSWRLIHRGLGHTTRISQSVLSIEDFETIDAGYYICTAQNLQGQTTVATTVESS", "length": 367, "header": "tr|A0A3Q1N8R2-1|F1N1R6_BOVIN Computationally mapped isoform of Platelet-derived growth factor receptor-like protein OS=Bos taurus OX=9913 GN=PDGFRL PE=4 SV=2 CANONICAL=F1N1R6-1" }, "locus": { "chromosome": "27", "start_pos": 19689634, "end_pos": 19636507, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086149.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086149.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067464.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067464.2" } ] } }, { "isoform_ac": "A0AAA9TCL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCL4/entry", "sequence": { "sequence": "MKIWLLLGLLLMHEALEDVTGQHPPKNKRPKEPGENRIKPTNKKVKPKIPKIKDRDSADPTPKTPSIMTQMMDKGRFQKPAATLSLVAGQTLELRCKGNKIGWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCTGYVCRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDLKRGFVYLQPHVGHQGVVYCKAEAGGKSQISVKYQLLYAEVPRGPPSTTILASSNKVKGGDDVSVLCTVLGEPDVEVEFRWTYPGQKRLLQDRLLRGKLPGRQKGARNHPGFPGKGRHAR", "length": 346, "header": "tr|A0AAA9TCL4-1|F1N1R6_BOVIN Computationally mapped isoform of Platelet-derived growth factor receptor-like protein OS=Bos taurus OX=9913 GN=PDGFRL PE=4 SV=1 CANONICAL=F1N1R6-1" }, "locus": { "chromosome": "27", "start_pos": 19709706, "end_pos": 19631368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088666.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088666.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095792.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095792.1" } ] } }, { "isoform_ac": "F1N1R6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R6/entry", "sequence": { "sequence": "MKIWLLLGLLLMHEALEDVTGQHPPKNKRPKEPGENRIKPTNKKVKPKIPKIKDRDSADPTPKTPSIMTQMMDKGRFQKPAATLSLVAGQTLELRCKGNKIGWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCTGYVCRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDLKRGFVYLQPHVGHQGVVYCKAEAGGKSQISVKYQLLYAEVPRGPPSTTILASSNKVKGGDDVSVLCTVLGEPDVEVEFRWTYPGQKDERPVTIQDSWRLIHRGLGHTTRISQSVLSIEDFETIDAGYYICTAQNLQGQTTVATTVESS", "length": 375, "header": "tr|F1N1R6-1|F1N1R6_BOVIN Isoform 1 of Platelet-derived growth factor receptor-like protein OS=Bos taurus OX=9913 GN=PDGFRL PE=4 SV=1 CANONICAL=F1N1R6-1" }, "locus": { "chromosome": "27", "start_pos": 19709706, "end_pos": 19636507, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002553.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002553.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002553.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002553.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SET2-1", "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "PDGFRL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKVWLLLGLLLVHEALEDVTGQHPPKNKRPKEPGENKIKPTNKKVKPKIPKIKDRDSADSVPKTQSIMIQMMDKGRFQKPAATLSLTAGQTLELRCKGNKIAWSYPAYLDTFKDTRLSVKQHERYGQLTLVNSTAADTGEFSCWGQLCNGYICRRDEAKTGSTYIFFTEKGELFVPSPSHFDVVYLNPDKQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDAKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYAEVPSGPPSTTILASANKVKGGDDISVLCTVLGEPDVEVEFRWIYPGLKDERPVTIQDAWRLIHRGLGHTTRISQSVLTVEDLETIDAGYYICTAQNLRGQTTVATTVEFS", "length": 375 }, "evidence": [ { "id": "F1N1R6", "url": "https://omabrowser.org/oma/group/F1N1R6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15198-1", "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "PDGFRL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVEFS", "length": 375 }, "evidence": [ { "id": "F1N1R6", "url": "https://omabrowser.org/oma/group/F1N1R6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5RJP7-1", "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "Pdgfrl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKVWLLLGLLLLHEALGDVAGQHPPKNKRPKEQGENRIKPTNKKAKPKIPKIKDRDTADSAPKSQSIMMQAMDNGRFQKPAATVSLMAGQSVELRCKGSKVEWSYPAYLDTFKDSRLTVKQNERYGQLTLVNSTTADTGEFSCWERLCNGYICRRDEARTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVPSGPPSTTILASSNKVRGGDDISVLCTVLGEPDVEVEFRWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLRGQTTVATTVEFS", "length": 375 }, "evidence": [ { "id": "F1N1R6", "url": "https://omabrowser.org/oma/group/F1N1R6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PE55-1", "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "Pdgfrl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKFWLLLGLLLLHEALEDVAGQHSPKNKRPKEQGENRIKPTNKKAKPKIPKVKDRDSTDSTAKSQSIMMQAMGNGRFQRPAATVSLLAGQTLELRCKGSKVEWSYPAYLDTFKDSRLTVKQSERYGQLTLVNSTAADTGEFSCWEQLCNGYICRRDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVPSGPPSTTILASSNKVRGGDDISVLCTVLGEPDVEVEFRWLFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVIIVEDFETIDAGYYICTAQNLRGQTTVATTVEFS", "length": 375 }, "evidence": [ { "id": "F1N1R6", "url": "https://omabrowser.org/oma/group/F1N1R6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N1R6", "url": "https://www.uniprot.org/uniprotkb/F1N1R6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "platelet-derived growth factor receptor activity", "id": "GO:0005017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005017", "evidence": [ { "database": "UniProtKB", "id": "F1N1R6", "url": "https://www.uniprot.org/uniprotkb/F1N1R6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1R6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 375, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1R6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1R6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 143, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2H6-1", "uniprot_ac": "F1N2H6", "uniprot_id": "F1N2H6_BOVIN", "mass": { "chemical_mass": 57063.0, "monoisotopic_mass": 57063.0 }, "refseq": { "ac": "XP_002690541", "name": "CD276 antigen", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690541" }, "gene_names": [ { "name": "CD276", "type": "recommended", "evidence": [ { "id": "F1N2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ] }, { "name": "CD276", "type": "synonym", "evidence": [ { "id": "XP_002690541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690541" } ] } ], "protein_names": [ { "name": "CD276 antigen", "type": "recommended", "evidence": [ { "id": "F1N2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2H6/entry#names_and_taxonomy" } ] }, { "name": "B7 homolog 3", "type": "synonym", "evidence": [ { "id": "F1N2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2H6/entry#names_and_taxonomy" } ] }, { "name": "CD276 antigen", "type": "synonym", "evidence": [ { "id": "XP_002690541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690541" } ] }, { "name": "Costimulatory molecule", "type": "synonym", "evidence": [ { "id": "F1N2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2H6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD276", "url": "https://www.uniprot.org/uniprotkb/F1N2H6", "locus": { "chromosome": "10", "start_pos": 20522347, "end_pos": 20490742, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019734", "url": "https://www.ensembl.org/id/ENSBTAG00000019734" } ] } } ], "crossref": [ { "id": "F1N2H6", "url": "https://alphafold.ebi.ac.uk/entry/F1N2H6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20934", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20934", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508656", "url": "https://www.ncbi.nlm.nih.gov/gene/508656", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508656", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508656", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1ND16", "url": "https://www.orthodb.org/?gene=A0A3Q1ND16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2H6", "url": "https://www.orthodb.org/?gene=F1N2H6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100:SF155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100:SF155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690541", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND16", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND16-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLCGPSSTGVSVAPALGVLWFCLTGAAVEVQVPEDPVVALVGTDATLRCSFSTEPGFSLAQLNLIWQLTDTKQLVHSFAEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVRIQDFGSATVSLQVAARYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPKAEVLWQDGQGAPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITPHRSPTGAVEVQVPEDPVVALVGTDATLRCSFSTEPGFSLAQLNLIWQLTDTKQLVHSFAEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVLWQDGQGAPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSICLVALLVALAFVCWRKIKQSCEEENAGAEDHDGDGEGSKTALRPLKHSENKEDDGPEIV", "length": 533, "header": "tr|F1N2H6-1|F1N2H6_BOVIN Isoform 1 of CD276 antigen OS=Bos taurus OX=9913 GN=CD276 PE=3 SV=4 CANONICAL=F1N2H6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ND16-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND16/entry", "sequence": { "sequence": "MLCGPSSTGVSVAPALGVLWFCLTGAAVEVQVPEDPVVALVGTDATLRCSFSTEPGFSLAQLNLIWQLTDTKQLVHSFAEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVRIQDFGSATVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVLWQDGQGAPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSICLVALLVALAFVCWRKIKQSCEEENAGAEDHDGDGEGSKTALRPLKHSENKEDDGPEIV", "length": 315, "header": "tr|A0A3Q1ND16-1|F1N2H6_BOVIN Computationally mapped isoform of CD276 antigen OS=Bos taurus OX=9913 GN=CD276 PE=3 SV=2 CANONICAL=F1N2H6-1" }, "locus": { "chromosome": "10", "start_pos": 20521343, "end_pos": 20508926, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082230.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082230.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069343.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069343.2" } ] } }, { "isoform_ac": "F1N2H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2H6/entry", "sequence": { "sequence": "MLCGPSSTGVSVAPALGVLWFCLTGAAVEVQVPEDPVVALVGTDATLRCSFSTEPGFSLAQLNLIWQLTDTKQLVHSFAEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVRIQDFGSATVSLQVAARYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPKAEVLWQDGQGAPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITPHRSPTGAVEVQVPEDPVVALVGTDATLRCSFSTEPGFSLAQLNLIWQLTDTKQLVHSFAEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVLWQDGQGAPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSICLVALLVALAFVCWRKIKQSCEEENAGAEDHDGDGEGSKTALRPLKHSENKEDDGPEIV", "length": 533, "header": "tr|F1N2H6-1|F1N2H6_BOVIN Isoform 1 of CD276 antigen OS=Bos taurus OX=9913 GN=CD276 PE=3 SV=4 CANONICAL=F1N2H6-1" }, "locus": { "chromosome": "10", "start_pos": 20521343, "end_pos": 20508926, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026300.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026300.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026300.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026300.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508656", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508656", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "T cell activation", "id": "GO:0042110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042110", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "positive regulation of T cell proliferation", "id": "GO:0042102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042102", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "regulation of type II interferon production", "id": "GO:0032649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032649", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" }, { "name": "positive regulation of type II interferon production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "F1N2H6", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2H6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2H6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2H6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2H6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 138, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 214, "end_pos": 216 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7U2-1", "uniprot_ac": "F1N7U2", "uniprot_id": "F1N7U2_BOVIN", "mass": { "chemical_mass": 72425.0, "monoisotopic_mass": 72425.0 }, "refseq": {}, "gene_names": [ { "name": "NPLOC4", "type": "recommended", "evidence": [ { "id": "F1N7U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ] } ], "protein_names": [ { "name": "Nuclear protein localization protein 4 homolog", "type": "recommended", "evidence": [ { "id": "F1N7U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7U2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2#function" }, { "database": "UniProtKB", "id": "ARBA00056115", "url": "https://www.uniprot.org/uniprotkb/ARBA00056115#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPLOC4", "url": "https://www.uniprot.org/uniprotkb/F1N7U2", "locus": { "chromosome": "19", "start_pos": 51220472, "end_pos": 51171671, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019105", "url": "https://www.ensembl.org/id/ENSBTAG00000019105" } ] } } ], "crossref": [ { "id": "F1N7U2", "url": "https://alphafold.ebi.ac.uk/entry/F1N7U2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019105", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019105", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08061", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08061", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016563", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016563", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N7U2", "url": "https://www.orthodb.org/?gene=F1N7U2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12710", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12710", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12710:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12710:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11543", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11543", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RST8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RST8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVU7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVU7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6J4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6J4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7U2-1", "url": "https://www.uniprot.org/uniprotkb/F1N7U2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERRWRRRREAGAGAEAGVGAARPVGRQAAAARGPSPDTGAATMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSNLAGPSSEMETSAPQGLKACGAPNVVEDEIDQYLSRQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSHNTSSVFLDTISDFHLLLFLVTNDVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLQEYGAVGGSTHAASSAMWACQHCTFMNQPGTGHCEMCSLPRT", "length": 651, "header": "tr|F1N7U2-1|F1N7U2_BOVIN Isoform 1 of Nuclear protein localization protein 4 homolog OS=Bos taurus OX=9913 GN=NPLOC4 PE=3 SV=4 CANONICAL=F1N7U2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RST8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST8/entry", "sequence": { "sequence": "MLVSIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSNLAGPSSEMETSAPQGLKACGAPNVVEDEIDQYLSRQDGKIYRSRDPQLRLMRTT", "length": 134, "header": "tr|A0AAA9RST8-1|F1N7U2_BOVIN Computationally mapped isoform of Nuclear protein localization protein 4 homolog OS=Bos taurus OX=9913 GN=NPLOC4 PE=3 SV=1 CANONICAL=F1N7U2-1" }, "locus": { "chromosome": "19", "start_pos": 51188489, "end_pos": 51175676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116557.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116557.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074750.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074750.1" } ] } }, { "isoform_ac": "A0ABI0NVU7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVU7/entry", "sequence": { "sequence": "MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSNLAGPSSEMETSAPQGLKACGAPNVVEDEIDQYLSRQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSHNTSSVFLDTISDFHLLLFLVTNDVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLQEYGAVGGSTHAASSAMWACQHCTFMNQPGTGHCEMCSLPRT", "length": 579, "header": "tr|A0ABI0NVU7-1|A0ABI0NVU7_BOVIN Computationally mapped isoform of NPL4 homolog, ubiquitin recognition factor OS=Bos taurus OX=9913 GN=NPLOC4 PE=4 SV=1 CANONICAL=F1N7U2-1" }, "locus": { "chromosome": "19", "start_pos": 51219816, "end_pos": 51172007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143141.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143141.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104928.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104928.1" } ] } }, { "isoform_ac": "A0ABI0P6J4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6J4/entry", "sequence": { "sequence": "MAESIVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSNLAGPSSEMETSAPQGLKACGAPNVVEDEIDQYLSRQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSHNTSSVFLDTISDFHLLLFLVTNDVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLQEYGAVGGSTHAASSAMWACQHCTFMNQPGTGHCEMCSLPRT", "length": 581, "header": "tr|A0ABI0P6J4-1|A0ABI0P6J4_BOVIN Computationally mapped isoform of Nuclear protein localization protein 4 homolog OS=Bos taurus OX=9913 GN=NPLOC4 PE=3 SV=1 CANONICAL=F1N7U2-1" }, "locus": { "chromosome": "19", "start_pos": 51219816, "end_pos": 51172007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137432.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137432.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107276.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107276.1" } ] } }, { "isoform_ac": "F1N7U2-1", "url": "https://www.uniprot.org/uniprotkb/F1N7U2/entry", "sequence": { "sequence": "MERRWRRRREAGAGAEAGVGAARPVGRQAAAARGPSPDTGAATMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSNLAGPSSEMETSAPQGLKACGAPNVVEDEIDQYLSRQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSHNTSSVFLDTISDFHLLLFLVTNDVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLQEYGAVGGSTHAASSAMWACQHCTFMNQPGTGHCEMCSLPRT", "length": 651, "header": "tr|F1N7U2-1|F1N7U2_BOVIN Isoform 1 of Nuclear protein localization protein 4 homolog OS=Bos taurus OX=9913 GN=NPLOC4 PE=3 SV=4 CANONICAL=F1N7U2-1" }, "locus": { "chromosome": "19", "start_pos": 51219816, "end_pos": 51171878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042613.6", "url": "https://www.ensembl.org/id/ENSBTAT00000042613.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040249.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040249.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-110320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110320", "resource": "Reactome", "description": "Translesion Synthesis by POLH" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9755511", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "retrograde protein transport, ER to cytosol", "id": "GO:0030970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030970", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "negative regulation of RIG-I signaling pathway", "id": "GO:0039536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039536", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "VCP-NPL4-UFD1 AAA ATPase complex", "id": "GO:0034098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034098", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "UFD1-NPL4 complex", "id": "GO:0036501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036501", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "F1N7U2", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 538, "end_pos": 540, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7U2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 651, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7U2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7U2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" }, { "id": "PS50249", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50249" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MPN", "eco_id": "ECO_0000259", "start_pos": 269, "end_pos": 406, "start_aa": "Ile", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N7U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7U2" }, { "id": "PS50199", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RanBP2-type", "eco_id": "ECO_0000259", "start_pos": 623, "end_pos": 651, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 538, "end_pos": 540 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N535-1", "uniprot_ac": "F1N535", "uniprot_id": "F1N535_BOVIN", "mass": { "chemical_mass": 132455.0, "monoisotopic_mass": 132455.0 }, "refseq": {}, "gene_names": [ { "name": "NCAPG2", "type": "recommended", "evidence": [ { "id": "F1N535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ] } ], "protein_names": [ { "name": "Non-SMC condensin II complex subunit G2", "type": "synonym", "evidence": [ { "id": "F1N535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N535/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCAPG2", "url": "https://www.uniprot.org/uniprotkb/F1N535", "locus": { "chromosome": "4", "start_pos": 119334801, "end_pos": 119408828, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016131", "url": "https://www.ensembl.org/id/ENSBTAG00000016131" } ] } } ], "crossref": [ { "id": "F1N535", "url": "https://alphafold.ebi.ac.uk/entry/F1N535", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016131", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016131", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516644", "url": "https://www.ncbi.nlm.nih.gov/gene/516644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N535", "url": "https://www.orthodb.org/?gene=F1N535", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16199:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16199:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12422", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2299718", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2299718", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RTE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N535-1", "url": "https://www.uniprot.org/uniprotkb/F1N535-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKRETFIQAVSKELIGKFLQFIQLDNDTCDPFNLNELIDELSRKQKEELWQRLKNLLVDMLLESPVEGWQTAEAPSEDSVRAEQDSKMHRNIEIIHAVTSVILASVSVINERENCEPLLECAVILNGILYALPEGERALQGSIQDLCVKWWERGLPAKENMGKTAFIMLLRRSLRTKTGADICRLWRIHQALYCFDYHLEESREIKDMLLECFINVNYIKKEEGRRFLSSLFNWNINFIKMIHGTIKNQLQGLPKSLMVHIAEIYFRAWKKASGKILEAIENDCIQDLMHHGVHLPRRSPVHPRVRKVLSYFHHQKEVRQGVEEMLYKLYKPILWRGLKARNSEVRSNAALLFVEAFPIRHPGFNAIEMDSEIQKQFEELYSLLEDPYPMVRSAGILGVCKITSKYWEMMPPTILIDLLKKVTEELAFDLSSADVRCSVFKCLPIILDNKLSHPLLEQLLPALKYCLHDNSEKVRVAFVDMLLKVKAVRAAKFWKICPMEHILARLESDSRPVCRRLVGLIFNSFLPVNQPEAVWCERCVALLQMNHAAARRFYQHAHEHTACTNIAKLIHVIRHCLNACIRRALSACREDAEEPGKENASALDQTLSVSDAASMAGLLETVVILWRSIHRSLENNKEARVYTVDKFASVLPQYMRVFTDERCRAPLCVLASLMPAPAVPTFSCGVISTLRNQEEGTADRTYCILLDCLCSWGHVGHVLELVFDWLPEEPPQSKGNSASKRKVRVQDPCPVKPGLALVFVEYLLTHPKNRECLLSAPQKKLNCLLKALETSKATVSSPPVRAARPEPGLRSPVLQGNLESILQTPDGSPPRLSEGTALRAFSLYCRLSIHLQHKFCSEGKVYLSTLEDTGSWLESKVLSFIRDQDEEYLKLHRVVYQQIIQTYLTVCKDVIMVGLGDCKFQTHLLQWSLGIMQTVKGFFYVSLLLGILKEITGSSLTWKTDSEEEVAVVFDMVQKVFQQMLECMAWSFKKQPEEGLQLLYSVQTPLHEFISTVQSWHVDKPVHRGVFSTLIAASVVEISHWLRKVSDTEELTPPEGLSALPPFSRCLIGIIIKSPNLVRSFLDELKACVISEDIEGIVCLTAVVHIILVINKGKHKTSKVKDVAASIERKLKTFMEITLEEDSLERFLYESSSRTLGALLNS", "length": 1163, "header": "tr|F1N535-1|F1N535_BOVIN Isoform 1 of Non-SMC condensin II complex subunit G2 OS=Bos taurus OX=9913 GN=NCAPG2 PE=4 SV=2 CANONICAL=F1N535-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTE1/entry", "sequence": { "sequence": "MEKRETFIQAVSKELIGKFLQFIQLDNDTCDPFNLNELIDELSRKQKEELWQRLKNLLVDMLLESPVEGWQTAEAPSEDSVRAEQDSKMHRNIEIIHAVTSVILASVSVINERENCEPLLECAVILNGILYALPEGERALQGSIQDLCVKWWERGLPAKENMGKTAFIMLLRRSLRTKTGADICRLWRIHQALYCFDYHLEESREIKDMLLECFINVNYIKKEEGRRFLSSLFNWNINFIKMIHGTIKNQLQGLPKSLMVHIAEIYFRAWKKASGKILEVLSYFHHQKEVRQGVEEMLYKLYKPILWRGLKARNSEVRSNAALLFVEAFPIRHPGFNAIEMDSEIQKQFEELYSLLEDPYPMVRSAGILGVCKITSKYWEMMPPTILIDLLKKVTEELAFDLSSADVRCSVFKCLPIILDNKLSHPLLEQLLPALKYCLHDNSEKVRVAFVDMLLKVKAVRAAKFWKICPMEHILARLESDSRPVCRRLVGLIFNSFLPVNQPEAVWCERCVALLQMNHAAARRFYQHAHEHTACTNIAKLIHVIRHCLNACIRRALSACREDAEEPGKENASALDQTLSVSDAASMAGLLETVVILWRSIHRSLENNKEARVYTVDKFASVLPQYMRVFTDERCRAPLCVLASLMPAPAVPTFSCGVISTLRNQEEGTADRTYCILLDCLCSWGHVGHVLELVFDWLPEEPPQSKGNSASKRKVRVQDPCPVKPGLALVFVEYLLTHPKNRECLLSAPQKKLNCLLKALETSKGNLESILQTPDGSPPRLSEGTALRAFSLYCRLSIHLQHKFCSEGKVYLSTLEDTGSWLESKVLSFIRDQDEEYLKLHRVVYQQIIQTYLTVCKDVIMVGLGDCKFQTHLLQWSLGIMQTVKGFFYVSLLLGILKEITGSSLTWKTDSEEEVAVVFDMVQKVFQQMLECMAWSFKKQPEEGLQLLYSVQTPLHEFISTVQSWHVDKPVHRGVFSTLIAASVVEISHWLRKVSDTEELTPPEGLSALPPFSRCLIGIIIKSPNLVRSFLDELKACVISEDIEGIVCLTAVVHIILVINKGKHKTSKVKDVAASIERKLKTFMEITLEEDSLERFLYESSSRTLGALLNS", "length": 1111, "header": "tr|A0AAA9RTE1-1|F1N535_BOVIN Computationally mapped isoform of Non-SMC condensin II complex subunit G2 OS=Bos taurus OX=9913 GN=NCAPG2 PE=4 SV=1 CANONICAL=F1N535-1" }, "locus": { "chromosome": "4", "start_pos": 119406063, "end_pos": 119335156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110136.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110136.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075133.1" } ] } }, { "isoform_ac": "A0AAA9TGA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA6/entry", "sequence": { "sequence": "MEKRETFIQAVSKELIGKFLQFIQLDNDTCDPFNLNELIDELSRKQKEELWQRLKNLLVDMLLESPVEGWQTAEAPSEDSVRAEQDSKMHRNIEIIHAVTSVILASVSVINERENCEPLLECAVILNGILYALPEGERALQGSIQDLCVKWWERGLPAKENMGKTAFIMLLRRSLRTKTGADICRLWRIHQALYCFDYHLEESREIKDMLLECFINVNYIKKEEGRRFLSSLFNWNINFIKMIHGTIKNQLQGLPKSLMVHIAEIYFRAWKKASGKILEAIENDCIQDLMHHGVHLPRRSPVHPRVRKVLSYFHHQKEVRQGVEEMLYKLYKPILWRGLKARNSEVRSNAALLFVEAFPIRHPGFNAIEMDSEIQKQFEELYSLLEDPYPMVRSAGILGVCKITSKYWEMMPPTILIDLLKKVTEELAFDLSSADVRCSVFKCLPIILDNKLSHPLLEQLLPALKYCLHDNSEKVRVAFVDMLLKVKAVRAAKFWKICPMEHILARLESDSRPVCRRLVGLIFNSFLPVNQPEAVWCERCVALLQMNHAAARRFYQHAHEHTACTNIAKLIHVIRHCLNACIRRALSACREDAEEPGKENASALDQTLSVSDAASMAGLLETVVILWRSIHRSLENNKEARVYTVDKFASVLPQYMRVFTDERCRAPLCVLASLMPAPAVPTFSCGVISTLRNQEEGTADRTYCILLDCLCSWGHVGHVLELVFDWLPEEPPQSKGNSASKRKVRVQDPCPVKPGLALVFVEYLLTHPKNRECLLSAPQKKLNCLLKALETSKGNLESILQTPDGSPPRLSEGTALRAFSLYCRLSIHLQHKTYLTVCKDVIMVGLGDCKFQTHLLQWSLGIMQTVKGFFYVSLLLGILKEITGSSLTWKTDSEEEVAVVFDMVQKVFQQMLECMAWSFKKQPEEGLQLLYSVQTPLHEFISTVQSWHVDKPVHRGVFSTLIAASVVEISHWLRKVSDTEELTPPEGLSALPPFSRCLIGIIIKSPNLVRSFLDELKACVISEDIEGIVCLTAVVHIILVINKGKHKTSKVKDVAASIERKLKTFMEITLEEDSLERFLYESSSRTLGALLNS", "length": 1093, "header": "tr|A0AAA9TGA6-1|F1N535_BOVIN Computationally mapped isoform of Non-SMC condensin II complex subunit G2 OS=Bos taurus OX=9913 GN=NCAPG2 PE=4 SV=1 CANONICAL=F1N535-1" }, "locus": { "chromosome": "4", "start_pos": 119406063, "end_pos": 119335156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130787.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130787.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095901.1" } ] } }, { "isoform_ac": "F1N535-1", "url": "https://www.uniprot.org/uniprotkb/F1N535/entry", "sequence": { "sequence": "MEKRETFIQAVSKELIGKFLQFIQLDNDTCDPFNLNELIDELSRKQKEELWQRLKNLLVDMLLESPVEGWQTAEAPSEDSVRAEQDSKMHRNIEIIHAVTSVILASVSVINERENCEPLLECAVILNGILYALPEGERALQGSIQDLCVKWWERGLPAKENMGKTAFIMLLRRSLRTKTGADICRLWRIHQALYCFDYHLEESREIKDMLLECFINVNYIKKEEGRRFLSSLFNWNINFIKMIHGTIKNQLQGLPKSLMVHIAEIYFRAWKKASGKILEAIENDCIQDLMHHGVHLPRRSPVHPRVRKVLSYFHHQKEVRQGVEEMLYKLYKPILWRGLKARNSEVRSNAALLFVEAFPIRHPGFNAIEMDSEIQKQFEELYSLLEDPYPMVRSAGILGVCKITSKYWEMMPPTILIDLLKKVTEELAFDLSSADVRCSVFKCLPIILDNKLSHPLLEQLLPALKYCLHDNSEKVRVAFVDMLLKVKAVRAAKFWKICPMEHILARLESDSRPVCRRLVGLIFNSFLPVNQPEAVWCERCVALLQMNHAAARRFYQHAHEHTACTNIAKLIHVIRHCLNACIRRALSACREDAEEPGKENASALDQTLSVSDAASMAGLLETVVILWRSIHRSLENNKEARVYTVDKFASVLPQYMRVFTDERCRAPLCVLASLMPAPAVPTFSCGVISTLRNQEEGTADRTYCILLDCLCSWGHVGHVLELVFDWLPEEPPQSKGNSASKRKVRVQDPCPVKPGLALVFVEYLLTHPKNRECLLSAPQKKLNCLLKALETSKATVSSPPVRAARPEPGLRSPVLQGNLESILQTPDGSPPRLSEGTALRAFSLYCRLSIHLQHKFCSEGKVYLSTLEDTGSWLESKVLSFIRDQDEEYLKLHRVVYQQIIQTYLTVCKDVIMVGLGDCKFQTHLLQWSLGIMQTVKGFFYVSLLLGILKEITGSSLTWKTDSEEEVAVVFDMVQKVFQQMLECMAWSFKKQPEEGLQLLYSVQTPLHEFISTVQSWHVDKPVHRGVFSTLIAASVVEISHWLRKVSDTEELTPPEGLSALPPFSRCLIGIIIKSPNLVRSFLDELKACVISEDIEGIVCLTAVVHIILVINKGKHKTSKVKDVAASIERKLKTFMEITLEEDSLERFLYESSSRTLGALLNS", "length": 1163, "header": "tr|F1N535-1|F1N535_BOVIN Isoform 1 of Non-SMC condensin II complex subunit G2 OS=Bos taurus OX=9913 GN=NCAPG2 PE=4 SV=2 CANONICAL=F1N535-1" }, "locus": { "chromosome": "4", "start_pos": 119406063, "end_pos": 119335156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021476.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021476.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021476.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021476.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2299718", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2299718", "resource": "Reactome", "description": "Condensation of Prophase Chromosomes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear lumen", "id": "GO:0031981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031981", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "condensin complex", "id": "GO:0000796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000796", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "chromosome condensation", "id": "GO:0030261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030261", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "positive regulation of chromosome separation", "id": "GO:1905820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905820", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "positive regulation of chromosome segregation", "id": "GO:0051984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051984", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "mitotic chromosome condensation", "id": "GO:0007076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007076", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "mitotic sister chromatid segregation", "id": "GO:0000070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000070", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "bHLH transcription factor binding", "id": "GO:0043425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043425", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" }, { "name": "histone H4K20me1 reader activity", "id": "GO:0140117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140117", "evidence": [ { "database": "UniProtKB", "id": "F1N535", "url": "https://www.uniprot.org/uniprotkb/F1N535" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N535-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N535-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N535" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 27, "end_pos": 29 }, { "start_pos": 600, "end_pos": 602 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4G9-1", "uniprot_ac": "F2Z4G9", "uniprot_id": "F2Z4G9_BOVIN", "mass": { "chemical_mass": 36721.0, "monoisotopic_mass": 36721.0 }, "refseq": {}, "gene_names": [ { "name": "ANAPC10", "type": "recommended", "evidence": [ { "id": "F2Z4G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" } ] } ], "protein_names": [ { "name": "Anaphase-promoting complex subunit 10", "type": "recommended", "evidence": [ { "id": "F2Z4G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9/entry#names_and_taxonomy" } ] }, { "name": "Cyclosome subunit 10", "type": "synonym", "evidence": [ { "id": "F2Z4G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RVM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVM7#function" }, { "database": "UniProtKB", "id": "ARBA00045696", "url": "https://www.uniprot.org/uniprotkb/ARBA00045696#function" }, { "database": "UniProtKB", "id": "A0AAA9SAK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAK8#function" }, { "database": "UniProtKB", "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANAPC10", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9", "locus": { "chromosome": "17", "start_pos": 13350328, "end_pos": 13187173, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013326", "url": "https://www.ensembl.org/id/ENSBTAG00000013326" } ] } } ], "crossref": [ { "id": "F2Z4G9", "url": "https://alphafold.ebi.ac.uk/entry/F2Z4G9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013326", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013326", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08366", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08366", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783986", "url": "https://www.ncbi.nlm.nih.gov/gene/783986", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F2Z4G9", "url": "https://www.orthodb.org/?gene=F2Z4G9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12936", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12936", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12936:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12936:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174048", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174048", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174084", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174154", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174184", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176407", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176407", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176412", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176412", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-179409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-179409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2559582", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559582", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68867", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RVM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9A1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9A1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4G9-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPRCLDRGRLQLKANPLQSIHVPGETDSPCGGERRDQIGACFSLLSHTACSSGHRPKWRCPAAASRMPQGRNARARQGAPGGAVERGREGRLGLTSLYCDPSDISGEARRAWEAEWEWRGAAADPEKLSGSKQSPQASIFKMTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGVSTSGVSATIEVVLNKVFFTVS", "length": 332, "header": "tr|F2Z4G9-1|F2Z4G9_BOVIN Isoform 1 of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=3 SV=3 CANONICAL=F2Z4G9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVM7/entry", "sequence": { "sequence": "MSPRCLDRGRLQLKANPLQSIHVPGETDSPCGGERRDQIGACFSLLSHTACSSGHRPKWRCPAAASRMPQGRNARARQGAPGGAVERGREGRLGLTSLYCDPSDISGEARRAWEAEWEWRGAAADPEKLSGSKQSPQASIFKMTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIEVQDQV", "length": 315, "header": "tr|A0AAA9RVM7-1|F2Z4G9_BOVIN Computationally mapped isoform of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=3 SV=1 CANONICAL=F2Z4G9-1" }, "locus": { "chromosome": "17", "start_pos": 13290009, "end_pos": 13187215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120185.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120185.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077417.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077417.1" } ] } }, { "isoform_ac": "A0AAA9SAK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAK8/entry", "sequence": { "sequence": "MSPRCLDRGRLQLKANPLQSIHVPGETDSPCGGERRDQIGACFSLLSHTACSSGHRPKWRCPAAASRMPQGRNARARQGAPGGAVERGREGRLGLTSLYCDPSDISGEARRAWEAEWEWRGAAADPEKLSGSKQSPQASIFKMTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGVKHATWLADLSFPTKD", "length": 326, "header": "tr|A0AAA9SAK8-1|F2Z4G9_BOVIN Computationally mapped isoform of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=3 SV=1 CANONICAL=F2Z4G9-1" }, "locus": { "chromosome": "17", "start_pos": 13308426, "end_pos": 13187215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095450.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095450.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080938.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080938.1" } ] } }, { "isoform_ac": "A0AAA9T9A1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9A1/entry", "sequence": { "sequence": "MSPRCLDRGRLQLKANPLQSIHVPGETDSPCGGERRDQIGACFSLLSHTACSSGHRPKWRCPAAASRMPQGRNARARQGAPGGAVERGREGRLGLTSLYCDPSDISGEARRAWEAEWEWRGAAADPEKLSGSKQSPQASIFKMTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRYFIMENFRYTEKLKELNSEPQHTHTHILDYTIVSVLPYFIMIFSLSHFYVHFKIGCRYFYISPQIL", "length": 317, "header": "tr|A0AAA9T9A1-1|F2Z4G9_BOVIN Computationally mapped isoform of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=3 SV=1 CANONICAL=F2Z4G9-1" }, "locus": { "chromosome": "17", "start_pos": 13224227, "end_pos": 13187215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094576.1" } ] } }, { "isoform_ac": "F2Z4G9-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9/entry", "sequence": { "sequence": "MSPRCLDRGRLQLKANPLQSIHVPGETDSPCGGERRDQIGACFSLLSHTACSSGHRPKWRCPAAASRMPQGRNARARQGAPGGAVERGREGRLGLTSLYCDPSDISGEARRAWEAEWEWRGAAADPEKLSGSKQSPQASIFKMTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGVSTSGVSATIEVVLNKVFFTVS", "length": 332, "header": "tr|F2Z4G9-1|F2Z4G9_BOVIN Isoform 1 of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=3 SV=3 CANONICAL=F2Z4G9-1" }, "locus": { "chromosome": "17", "start_pos": 13350326, "end_pos": 13187215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017721.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017721.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017721.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017721.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-174048", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174048", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Cyclin B" }, { "id": "R-BTA-174084", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "resource": "Reactome", "description": "Autodegradation of Cdh1 by Cdh1:APC/C" }, { "id": "R-BTA-174154", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Securin" }, { "id": "R-BTA-174178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "resource": "Reactome", "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "id": "R-BTA-174184", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "resource": "Reactome", "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "id": "R-BTA-176407", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176407", "resource": "Reactome", "description": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" }, { "id": "R-BTA-176408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176408", "resource": "Reactome", "description": "Regulation of APC/C activators between G1/S and early anaphase" }, { "id": "R-BTA-176409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176409", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of mitotic proteins" }, { "id": "R-BTA-176412", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176412", "resource": "Reactome", "description": "Phosphorylation of the APC/C" }, { "id": "R-BTA-179409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-179409", "resource": "Reactome", "description": "APC-Cdc20 mediated degradation of Nek2A" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2559582", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559582", "resource": "Reactome", "description": "Senescence-Associated Secretory Phenotype (SASP)" }, { "id": "R-BTA-68867", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "resource": "Reactome", "description": "Assembly of the pre-replicative complex" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" } ], "pmid": "" }, { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "anaphase-promoting complex", "id": "GO:0005680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G9", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F2Z4G9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 332, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F2Z4G9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F2Z4G9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F2Z4G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G9" }, { "id": "PS51284", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51284" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DOC", "eco_id": "ECO_0000259", "start_pos": 143, "end_pos": 327, "start_aa": "Met", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7G0-1", "uniprot_ac": "F1N7G0", "uniprot_id": "F1N7G0_BOVIN", "mass": { "chemical_mass": 60028.0, "monoisotopic_mass": 60028.0 }, "refseq": { "ac": "XP_059747321", "name": "heterogeneous nuclear ribonucleoprotein L-like isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747321" }, "gene_names": [ { "name": "HNRNPLL", "type": "recommended", "evidence": [ { "id": "F1N7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ] }, { "name": "HNRNPLL", "type": "synonym", "evidence": [ { "id": "XP_059747321", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747321" } ] }, { "name": "HNRPLL", "type": "synonym", "evidence": [ { "id": "XP_059747321", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747321" } ] } ], "protein_names": [ { "name": "Heteroous nuclear ribonucleoprotein L like", "type": "synonym", "evidence": [ { "id": "F1N7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G0/entry#names_and_taxonomy" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein L-like isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059747321", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747321" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HNRNPLL", "url": "https://www.uniprot.org/uniprotkb/F1N7G0", "locus": { "chromosome": "11", "start_pos": 20895389, "end_pos": 20948016, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020567", "url": "https://www.ensembl.org/id/ENSBTAG00000020567" } ] } } ], "crossref": [ { "id": "F1N7G0", "url": "https://alphafold.ebi.ac.uk/entry/F1N7G0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020567", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020567", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12700", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12700", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12781", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12781", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12786", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12786", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534315", "url": "https://www.ncbi.nlm.nih.gov/gene/534315", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GKRLNVX", "url": "https://omabrowser.org/oma/group/GKRLNVX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N7G0", "url": "https://www.orthodb.org/?gene=F1N7G0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11835", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11835", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22976", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22976", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059747321", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747321", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RW20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7G0-1", "url": "https://www.uniprot.org/uniprotkb/F1N7G0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSSSSPRETYEEDRDYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMLMFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 541, "header": "tr|F1N7G0-1|F1N7G0_BOVIN Isoform 1 of Heteroous nuclear ribonucleoprotein L like OS=Bos taurus OX=9913 GN=HNRNPLL PE=4 SV=2 CANONICAL=F1N7G0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RW20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW20/entry", "sequence": { "sequence": "MSSSSSSPRETYEEDRDYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMLMFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPSYQHAL", "length": 529, "header": "tr|A0AAA9RW20-1|F1N7G0_BOVIN Computationally mapped isoform of Heteroous nuclear ribonucleoprotein L like OS=Bos taurus OX=9913 GN=HNRNPLL PE=4 SV=1 CANONICAL=F1N7G0-1" }, "locus": { "chromosome": "11", "start_pos": 20947763, "end_pos": 20895679, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121810.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121810.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075302.1" } ] } }, { "isoform_ac": "A0AAA9SEX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX9/entry", "sequence": { "sequence": "MSSSSSSPRETYEEDRDYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMLMFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 517, "header": "tr|A0AAA9SEX9-1|F1N7G0_BOVIN Computationally mapped isoform of Heteroous nuclear ribonucleoprotein L like OS=Bos taurus OX=9913 GN=HNRNPLL PE=4 SV=1 CANONICAL=F1N7G0-1" }, "locus": { "chromosome": "11", "start_pos": 20947763, "end_pos": 20911380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127586.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127586.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082394.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082394.1" } ] } }, { "isoform_ac": "A0AAA9TRY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY1/entry", "sequence": { "sequence": "MSSSSSSPRETYEEDRDYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 507, "header": "tr|A0AAA9TRY1-1|F1N7G0_BOVIN Computationally mapped isoform of Heteroous nuclear ribonucleoprotein L like OS=Bos taurus OX=9913 GN=HNRNPLL PE=4 SV=1 CANONICAL=F1N7G0-1" }, "locus": { "chromosome": "11", "start_pos": 20947763, "end_pos": 20911380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101023.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101023.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101132.1" } ] } }, { "isoform_ac": "F1N7G0-1", "url": "https://www.uniprot.org/uniprotkb/F1N7G0/entry", "sequence": { "sequence": "MSSSSSSPRETYEEDRDYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMLMFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 541, "header": "tr|F1N7G0-1|F1N7G0_BOVIN Isoform 1 of Heteroous nuclear ribonucleoprotein L like OS=Bos taurus OX=9913 GN=HNRNPLL PE=4 SV=2 CANONICAL=F1N7G0-1" }, "locus": { "chromosome": "11", "start_pos": 20947763, "end_pos": 20911380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027405.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027405.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027405.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027405.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M262-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein L-like", "gene_name": "Hnrnpll", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTSSSPKEETYEEDREFESQAKRLKTEEGEIVYSAEESENRQEATPQAGSDSDSGGGDRGSGGGGGDGEEGDGGEEGDGEEGDEGDGDERGSGGDEGGSGGGPRSMPPSTEGGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADVPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGDHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGSPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLPFIKYKVFDAKASAKTLSGLLEWKCKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 591 }, "evidence": [ { "id": "F1N7G0", "url": "https://omabrowser.org/oma/group/F1N7G0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1P0T4-1", "protein_name": "Heteroous nuclear ribonucleoprotein L like", "gene_name": "HNRNPLL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSPSSGDRYEEEEEEDGAYESQAKRLKPSAAAEEGEIEYSGAEESESRRDKVPPPRGGGFSGGDAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFEKVESAKKCVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVFCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFVKLCEDHEVLSFIKYKVFDPKPSAKTLSGLLEWECKTDAVEALTVLNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 543 }, "evidence": [ { "id": "F1N7G0", "url": "https://omabrowser.org/oma/group/F1N7G0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8WVV9-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein L-like", "gene_name": "HNRNPLL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSSSSSPRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 542 }, "evidence": [ { "id": "F1N7G0", "url": "https://omabrowser.org/oma/group/F1N7G0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q921F4-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein L-like", "gene_name": "Hnrnpll", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSSSSSPKEETYEEDREFESQAKRLKTEEGEIVYSAEESENRQEATPQAGSDSDSGGGDGGDGDGGSGGGGDGEEGEGGEEGDEGDGDEGGSGGDEGGSGGGPRSMPLSTEGGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADVPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGDHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGSPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLPFIKYKVFDAKASAKTLSGLLEWKCKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL", "length": 591 }, "evidence": [ { "id": "F1N7G0", "url": "https://omabrowser.org/oma/group/F1N7G0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" }, { "name": "positive regulation of RNA splicing", "id": "GO:0033120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033120", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "F1N7G0", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7G0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 541, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7G0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7G0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7G0" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 149, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 524, "end_pos": 526 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3U6-1", "uniprot_ac": "F1N3U6", "uniprot_id": "F1N3U6_BOVIN", "mass": { "chemical_mass": 77972.0, "monoisotopic_mass": 77972.0 }, "refseq": { "ac": "NP_001179955", "name": "UV radiation resistance-associated gene protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179955" }, "gene_names": [ { "name": "DGAT2", "type": "recommended", "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ] }, { "name": "UVRAG", "type": "recommended", "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ] }, { "name": "DGAT2", "type": "synonym", "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ] }, { "name": "UVRAG", "type": "synonym", "evidence": [ { "id": "NP_001179955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179955" }, { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ] } ], "protein_names": [ { "name": "UV radiation resistance associated", "type": "synonym", "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6/entry#names_and_taxonomy" } ] }, { "name": "UV radiation resistance-associated gene protein", "type": "synonym", "evidence": [ { "id": "NP_001179955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179955" } ] } ], "function": [ { "annotation": "Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RWA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWA1#function" }, { "database": "UniProtKB", "id": "ARBA00055895", "url": "https://www.uniprot.org/uniprotkb/ARBA00055895#function" }, { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UVRAG", "url": "https://www.uniprot.org/uniprotkb/F1N3U6", "locus": { "chromosome": "15", "start_pos": 55538967, "end_pos": 55212071, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016355", "url": "https://www.ensembl.org/id/ENSBTAG00000016355" } ] } } ], "crossref": [ { "id": "F1N3U6", "url": "https://alphafold.ebi.ac.uk/entry/F1N3U6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07987", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07987", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "404129", "url": "https://www.ncbi.nlm.nih.gov/gene/404129", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "614285", "url": "https://www.ncbi.nlm.nih.gov/gene/614285", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404129", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404129", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:614285", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614285", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IMGVACT", "url": "https://omabrowser.org/oma/group/IMGVACT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T836", "url": "https://www.orthodb.org/?gene=A0A140T836", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LHG3", "url": "https://www.orthodb.org/?gene=A0A3Q1LHG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNN3", "url": "https://www.orthodb.org/?gene=A0A3Q1LNN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4T1", "url": "https://www.orthodb.org/?gene=A0A3Q1M4T1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N3U6", "url": "https://www.orthodb.org/?gene=F1N3U6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12317:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12317:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15157:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15157:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03982", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03982", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179955", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10868", "url": "https://www.rhea-db.org/rhea/10868", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "11488", "url": "https://www.rhea-db.org/rhea/11488", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "37911", "url": "https://www.rhea-db.org/rhea/37911", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "37915", "url": "https://www.rhea-db.org/rhea/37915", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38071", "url": "https://www.rhea-db.org/rhea/38071", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38163", "url": "https://www.rhea-db.org/rhea/38163", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38175", "url": "https://www.rhea-db.org/rhea/38175", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38219", "url": "https://www.rhea-db.org/rhea/38219", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38435", "url": "https://www.rhea-db.org/rhea/38435", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38439", "url": "https://www.rhea-db.org/rhea/38439", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55340", "url": "https://www.rhea-db.org/rhea/55340", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140T836", "url": "https://www.uniprot.org/uniprotkb/A0A140T836", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T836-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T836-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4T1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4T1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3U6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3U6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNASASVGGPLPPPPTGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCNTEKVYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEDVYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKNILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNGLKKESECLQLKILVLRNELERQKKALGREVVLLHKEQIALQDKGSTFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPVIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGYRKRASSENERLQYKTPPPSYNSALVQPVTPVPSTGESDRKTASLSSSLDTSLDLSKENKKKGVDLGDSLNGSHVSVNTSQEQGQALSGPPATINGTLLPGEQASSSGAQLPGSFHPVSEAELCCTVEQAEEIIGMEATGFTSGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK", "length": 699, "header": "tr|F1N3U6-1|F1N3U6_BOVIN Isoform 1 of UV radiation resistance associated OS=Bos taurus OX=9913 GN=UVRAG PE=4 SV=2 CANONICAL=F1N3U6-1" }, "isoforms": [ { "isoform_ac": "A0A140T836-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T836/entry", "sequence": { "sequence": "MKTLIAAYSGVLRGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTSRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPRLERPTQQDIDLYHAMYVQALVKLFDQHKTKFGLPETEVLEVN", "length": 361, "header": "tr|A0A140T836-1|A0A140T836_BOVIN Computationally mapped isoform of Acyltransferase OS=Bos taurus OX=9913 GN=DGAT2 PE=3 SV=1 CANONICAL=F1N3U6-1" }, "locus": { "chromosome": "15", "start_pos": 55191943, "end_pos": 55160869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001536.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001536.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001536.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001536.5" } ] } }, { "isoform_ac": "A0A3Q1LHG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHG3/entry", "sequence": { "sequence": "MWSCRLSSVVLDIFGTLLPGTLLIGMAISSLIPTSHFTCVTLKRYTKNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEDVYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKNILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNGLKKESECLQLKILVLRNELERQKKALGREVVLLHKEQIALQDKGSTFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPVIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGYRKRASSENERLQYKTPPPSYNSALVQPVTPVPSTGESDRKTASLSSSLDTSLDLSKENKKKGVDLGDSLNGSHVSVNTSQEQGQALSGPPATINGTLLPGEQASSSGAQLPGSFHPVSEAELCCTVEQAEEIIGMEATGFTSGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK", "length": 656, "header": "tr|A0A3Q1LHG3-1|A0A3Q1LHG3_BOVIN Computationally mapped isoform of UV radiation resistance associated OS=Bos taurus OX=9913 GN=UVRAG PE=4 SV=1 CANONICAL=F1N3U6-1" }, "locus": { "chromosome": "15", "start_pos": 55537963, "end_pos": 55212306, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074939.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074939.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058173.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058173.1" } ] } }, { "isoform_ac": "A0A3Q1LNN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNN3/entry", "sequence": { "sequence": "KGADICLLSVTGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTSRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPRLERPTQQDIDLYHAMYVQALVKLFDQHKTKFGLPETEVLEVN", "length": 359, "header": "tr|A0A3Q1LNN3-1|F1N3U6_BOVIN Computationally mapped isoform of UV radiation resistance associated OS=Bos taurus OX=9913 GN=UVRAG PE=4 SV=2 CANONICAL=F1N3U6-1" }, "locus": { "chromosome": "15", "start_pos": 55191943, "end_pos": 55174515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070747.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070747.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058441.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058441.2" } ] } }, { "isoform_ac": "A0A3Q1M4T1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4T1/entry", "sequence": { "sequence": "MASVKGRPVMGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTSRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPRLERPTQQDIDLYHAMYVQALVKLFDQHKTKFGLPETEVLEVN", "length": 358, "header": "tr|A0A3Q1M4T1-1|F1N3U6_BOVIN Computationally mapped isoform of UV radiation resistance associated OS=Bos taurus OX=9913 GN=UVRAG PE=4 SV=2 CANONICAL=F1N3U6-1" }, "locus": { "chromosome": "15", "start_pos": 55191943, "end_pos": 55163124, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082392.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082392.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068611.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068611.2" } ] } }, { "isoform_ac": "A0AAA9RWA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWA1/entry", "sequence": { "sequence": "MNASASVGGPLPPPPTGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCNTEKVYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEDVYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKNILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNGLKKESECLQLKILVLRNELERQKKALGREVVLLHKEQIALQDKGSTFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQEKFWNLLSLPNSKDDGSIAVALGYTAHLVSMISFFLQVPLRYPVIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGYRKRASSENERLQYKTPPPSYNSALVQPVTPVPSTGESDRKTASLSSSLDTSLDLSKENKKKGVDLGDSLNGSHVSVNTSQEQGQALSGPPATINGTLLPGEQASSSGAQLPGSFHPVSEAELCCTVEQAEEIIGMEATGFTSGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK", "length": 710, "header": "tr|A0AAA9RWA1-1|F1N3U6_BOVIN Computationally mapped isoform of UV radiation resistance associated OS=Bos taurus OX=9913 GN=UVRAG PE=4 SV=1 CANONICAL=F1N3U6-1" }, "locus": { "chromosome": "15", "start_pos": 55537963, "end_pos": 55212212, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075393.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075393.1" } ] } }, { "isoform_ac": "F1N3U6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3U6/entry", "sequence": { "sequence": "MNASASVGGPLPPPPTGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCNTEKVYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEDVYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKNILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNGLKKESECLQLKILVLRNELERQKKALGREVVLLHKEQIALQDKGSTFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPVIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGYRKRASSENERLQYKTPPPSYNSALVQPVTPVPSTGESDRKTASLSSSLDTSLDLSKENKKKGVDLGDSLNGSHVSVNTSQEQGQALSGPPATINGTLLPGEQASSSGAQLPGSFHPVSEAELCCTVEQAEEIIGMEATGFTSGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK", "length": 699, "header": "tr|F1N3U6-1|F1N3U6_BOVIN Isoform 1 of UV radiation resistance associated OS=Bos taurus OX=9913 GN=UVRAG PE=4 SV=2 CANONICAL=F1N3U6-1" }, "locus": { "chromosome": "15", "start_pos": 55537963, "end_pos": 55212212, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021758.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021758.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021758.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021758.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 16, "start_aa": "Thr", "end_pos": 16, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr16", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 532, "start_aa": "Thr", "end_pos": 532, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr532", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:404129", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404129", "resource": "KEGG Pathway" }, { "id": "bta:614285", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614285", "resource": "KEGG Pathway" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XC94-1", "protein_name": "Acyltransferase", "gene_name": "DGAT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGGACGRGLVPSQGWGLLIFEPIPAVCSVICFLLFALSIGTGSSILSALQDLFWLSKSKVEKQLQIISVLQWVLTFLIMGIACTLILMYILCTDCWAIAALYLAWLVFDWNTPKKGGRRSQWVRNWAIWRYFRDYFPIRLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATGVSQKFPGIRPYLATLAGNFRMPILRDYLMSGGICPVNRDSIDYILSKNGSGNAIIIVVGGAAESLNCTPGKNSVTLRNRKGFVKLALRHGADLVPVYSFGENEVYKQVIFEEGSWGRWVQKKFQKHIGFAPCIFHGRGLFSSNTWGLLPYSKPITTVVGEPITIPKIDNPSQKEVDFYHSVYVDSLIKLFDKYKGRFGLPETEVLEVN", "length": 385 }, "evidence": [ { "id": "F1N3U6", "url": "https://omabrowser.org/oma/group/F1N3U6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HUS2-1", "protein_name": "Acyltransferase", "gene_name": "Dgat2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKTLIAAYSGVLRGERRAEAAGSENKNGGSALSREGSGRWGTGSSILSALQDIFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGIACSVILMYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN", "length": 388 }, "evidence": [ { "id": "F1N3U6", "url": "https://omabrowser.org/oma/group/F1N3U6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5FVP8-1", "protein_name": "Diacylglycerol O-acyltransferase 2", "gene_name": "Dgat2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGSSILSALQDIFSVTWLNRSKVEKHLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAALYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIVIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITVPKLEHPTQKDIDLYHTMYMEALVKLFDNHKTKFGLPETEVLEVN", "length": 388 }, "evidence": [ { "id": "F1N3U6", "url": "https://omabrowser.org/oma/group/F1N3U6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96PD7-1", "protein_name": "Diacylglycerol O-acyltransferase 2", "gene_name": "DGAT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN", "length": 388 }, "evidence": [ { "id": "F1N3U6", "url": "https://omabrowser.org/oma/group/F1N3U6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCV3-1", "protein_name": "Diacylglycerol O-acyltransferase 2", "gene_name": "Dgat2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGSSILSALQDIFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN", "length": 388 }, "evidence": [ { "id": "F1N3U6", "url": "https://omabrowser.org/oma/group/F1N3U6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "double-strand break repair via classical nonhomologous end joining", "id": "GO:0097680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097680", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate biosynthetic process", "id": "GO:0036092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036092", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "maintenance of Golgi location", "id": "GO:0051684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051684", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "centrosome cycle", "id": "GO:0007098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007098", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "spindle organization", "id": "GO:0007051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007051", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "receptor catabolic process", "id": "GO:0032801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032801", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "SNARE complex assembly", "id": "GO:0035493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035493", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "cellular response to oleic acid", "id": "GO:0071400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071400", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "fatty acid homeostasis", "id": "GO:0055089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055089", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA metabolic process", "id": "GO:0035336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035336", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "diacylglycerol biosynthetic process", "id": "GO:0006651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006651", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "low-density lipoprotein particle clearance", "id": "GO:0034383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034383", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "lipid storage", "id": "GO:0019915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019915", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "triglyceride biosynthetic process", "id": "GO:0019432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019432", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "glycerol metabolic process", "id": "GO:0006071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006071", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "fat pad development", "id": "GO:0060613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060613", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "intracellular triglyceride homeostasis", "id": "GO:0035356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035356", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "monoacylglycerol biosynthetic process", "id": "GO:0006640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006640", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 20, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "DNA-dependent protein kinase complex", "id": "GO:0070418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070418", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "lytic vacuole", "id": "GO:0000323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000323", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "perinuclear endoplasmic reticulum membrane", "id": "GO:1990578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990578", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "diacylglycerol O-acyltransferase activity", "id": "GO:0004144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004144", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "2-acylglycerol O-acyltransferase activity", "id": "GO:0003846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003846", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" }, { "name": "retinol O-fatty-acyltransferase activity", "id": "GO:0050252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050252", "evidence": [ { "database": "UniProtKB", "id": "F1N3U6", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 573, "end_pos": 575, "annotation": "n_glycosylation_sequon" }, { "start_pos": 580, "end_pos": 582, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10868", "name": "", "equation": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1", "Q0VCR6-1" ], "evidence": [ { "id": "10868", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10868" } ] }, { "id": "11488", "name": "", "equation": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "11488", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11488" } ] }, { "id": "37911", "name": "", "equation": "2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "37911", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37911" } ] }, { "id": "37915", "name": "", "equation": "1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ7-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "37915", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37915" } ] }, { "id": "38071", "name": "", "equation": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "38071", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38071" } ] }, { "id": "38163", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "38163", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38163" } ] }, { "id": "38175", "name": "", "equation": "all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "38175", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38175" } ] }, { "id": "38219", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6QP72-1", "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1", "Q0VCR6-1" ], "evidence": [ { "id": "38219", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38219" } ] }, { "id": "38435", "name": "", "equation": "1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "38435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38435" } ] }, { "id": "38439", "name": "", "equation": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "38439", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38439" } ] }, { "id": "55340", "name": "", "equation": "1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1" ], "evidence": [ { "id": "55340", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55340" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A6QP72", "gene_name": "DGAT2L6", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "A6QP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ] } ] }, { "uniprot_ac": "F1MIW3", "gene_name": "DGAT1", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "F1MIW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIW3" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "F1MIW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIW3" } ] } ] }, { "uniprot_ac": "F1N3U6", "gene_name": "UVRAG", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ] } ] }, { "uniprot_ac": "Q0VCR6", "gene_name": "TMEM68", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q0VCR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR6" } ] }, { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q0VCR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR6" } ] }, { "ec_number": "2.3.1.22", "activity": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA.", "evidence": [ { "id": "Q0VCR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR6" } ] } ] }, { "uniprot_ac": "Q70VZ7", "gene_name": "MOGAT1", "activity": [ { "ec_number": "2.3.1.22", "activity": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA.", "evidence": [ { "id": "Q70VZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ7" } ] }, { "ec_number": "2.3.1.22", "activity": "", "evidence": [ { "id": "Q70VZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ7" } ] } ] }, { "uniprot_ac": "Q70VZ8", "gene_name": "DGAT2", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q70VZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ8" } ] }, { "ec_number": "2.3.1.76", "activity": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA.", "evidence": [ { "id": "Q70VZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ8" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "Q70VZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ8" } ] } ] }, { "uniprot_ac": "Q8MK44", "gene_name": "DGAT1", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q8MK44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MK44" } ] }, { "ec_number": "2.3.1.76", "activity": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA.", "evidence": [ { "id": "Q8MK44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MK44" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "Q8MK44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MK44" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3U6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 699, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3U6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3U6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 149, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 16, 532 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 }, { "start_pos": 573, "end_pos": 575 }, { "start_pos": 580, "end_pos": 582 }, { "start_pos": 597, "end_pos": 599 }, { "start_pos": 686, "end_pos": 688 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N334-1", "uniprot_ac": "F1N334", "uniprot_id": "F1N334_BOVIN", "mass": { "chemical_mass": 33530.0, "monoisotopic_mass": 33530.0 }, "refseq": { "ac": "XP_059731214", "name": "short-chain dehydrogenase/reductase 3 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731214" }, "gene_names": [ { "name": "DHRS3", "type": "recommended", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ] }, { "name": "DHRS3", "type": "synonym", "evidence": [ { "id": "XP_059731214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731214" } ] }, { "name": "SDR1", "type": "synonym", "evidence": [ { "id": "XP_059731214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731214" } ] }, { "name": "retSDR1", "type": "synonym", "evidence": [ { "id": "XP_059731214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731214" } ] } ], "protein_names": [ { "name": "Short-chain dehydrogenase/reductase 3", "type": "recommended", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.300", "type": "synonym", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334/entry#names_and_taxonomy" } ] }, { "name": "Retinal short-chain dehydrogenase/reductase 1", "type": "synonym", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334/entry#names_and_taxonomy" } ] }, { "name": "short-chain dehydrogenase/reductase 3 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_059731214", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731214" } ] } ], "function": [ { "annotation": "Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334#function" }, { "database": "UniProtKB", "id": "ARBA00059620", "url": "https://www.uniprot.org/uniprotkb/ARBA00059620#function" }, { "database": "UniProtKB", "id": "A0AAA9RWM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWM9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHRS3", "url": "https://www.uniprot.org/uniprotkb/F1N334", "locus": { "chromosome": "16", "start_pos": 41160245, "end_pos": 41109610, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024493", "url": "https://www.ensembl.org/id/ENSBTAG00000024493" } ] } } ], "crossref": [ { "id": "F1N334", "url": "https://alphafold.ebi.ac.uk/entry/F1N334", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05339", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05339", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281482", "url": "https://www.ncbi.nlm.nih.gov/gene/281482", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NWYAVLP", "url": "https://omabrowser.org/oma/group/NWYAVLP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N334", "url": "https://www.orthodb.org/?gene=F1N334", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24322", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24322:SF483", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322:SF483", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2187335", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2187335", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5365859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059731214", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731214", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "25033", "url": "https://www.rhea-db.org/rhea/25033", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RWM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N334-1", "url": "https://www.uniprot.org/uniprotkb/F1N334-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVWKRLGALVVFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALIILKSILPQAALEEIHKFSGTYTCMNTFKGRT", "length": 302, "header": "tr|F1N334-1|F1N334_BOVIN Isoform 1 of Short-chain dehydrogenase/reductase 3 OS=Bos taurus OX=9913 GN=DHRS3 PE=3 SV=3 CANONICAL=F1N334-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWM9/entry", "sequence": { "sequence": "MDQGELLFCSVRGVSPPPPGSAARRMVWKRLGALVVFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALIILKSILPQAALEEIHKFSGTYTCMNTFKGRT", "length": 327, "header": "tr|A0AAA9RWM9-1|F1N334_BOVIN Computationally mapped isoform of Short-chain dehydrogenase/reductase 3 OS=Bos taurus OX=9913 GN=DHRS3 PE=3 SV=1 CANONICAL=F1N334-1" }, "locus": { "chromosome": "16", "start_pos": 41159806, "end_pos": 41109809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103862.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103862.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076861.1" } ] } }, { "isoform_ac": "F1N334-1", "url": "https://www.uniprot.org/uniprotkb/F1N334/entry", "sequence": { "sequence": "MVWKRLGALVVFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALIILKSILPQAALEEIHKFSGTYTCMNTFKGRT", "length": 302, "header": "tr|F1N334-1|F1N334_BOVIN Isoform 1 of Short-chain dehydrogenase/reductase 3 OS=Bos taurus OX=9913 GN=DHRS3 PE=3 SV=3 CANONICAL=F1N334-1" }, "locus": { "chromosome": "16", "start_pos": 41159806, "end_pos": 41111140, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034028.3", "url": "https://www.ensembl.org/id/ENSBTAT00000034028.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033930.3", "url": "https://www.ensembl.org/id/ENSBTAP00000033930.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2187335", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2187335", "resource": "Reactome", "description": "The retinoid cycle in cones (daylight vision)" }, { "id": "R-BTA-5365859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5365859", "resource": "Reactome", "description": "RA biosynthesis pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RF61-1", "protein_name": "Short-chain dehydrogenase/reductase 3", "gene_name": "DHRS3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVWKWLGALVVFPLQMIYLVVKAAIGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQTLLLLPWTMHVLIILKSILPQAALEEIHRFSGTYTCMNTFKGRT", "length": 302 }, "evidence": [ { "id": "F1N334", "url": "https://omabrowser.org/oma/group/F1N334/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75911-1", "protein_name": "Short-chain dehydrogenase/reductase 3", "gene_name": "DHRS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT", "length": 302 }, "evidence": [ { "id": "F1N334", "url": "https://omabrowser.org/oma/group/F1N334/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88876-1", "protein_name": "Short-chain dehydrogenase/reductase 3", "gene_name": "Dhrs3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVWKWLGALVVFPLQMIYLVTKAAVGMVLPPKLRDLSRESVLITGGGRGIGRHLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQMAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHVNTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVDAVQQNQALLLLPWTMNILIILKSILPQAALEEIHRFSGTYTCMNTFKGRT", "length": 302 }, "evidence": [ { "id": "F1N334", "url": "https://omabrowser.org/oma/group/F1N334/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "all-trans-retinol dehydrogenase (NAD+) activity", "id": "GO:0004745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004745", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "pmid": "" }, { "name": "all-trans-retinol dehydrogenase (NADP+) activity", "id": "GO:0052650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052650", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "retinoid metabolic process", "id": "GO:0001523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001523", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "pmid": "" }, { "name": "regulation of retinoic acid receptor signaling pathway", "id": "GO:0048385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048385", "evidence": [ { "database": "UniProtKB", "id": "F1N334", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25033", "name": "", "equation": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YUM7-1", "A0A493UA87-1", "Q8SPU8-1", "P59837-1", "P16116-1", "Q17QW3-1", "Q8HZT6-1", "Q9N126-1", "O77769-1", "E1BM93-1", "F1MD39-1", "F1N334-1" ], "evidence": [ { "id": "25033", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25033" } ] }, { "id": "R-BTA-2465940", "name": "atRAL is reduced to atROL", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, photoreceptor outer segment membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N334-1" ], "evidence": [ { "id": "R-BTA-2465940", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2465940" } ] }, { "id": "R-BTA-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-975599" ], "enzyme_list": [ "E1BM93-1", "Q17QW3-1", "F1N334-1" ], "evidence": [ { "id": "R-BTA-5419165", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419165" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-975599", "participant_name": "atROL [cytosol]", "crossref": [ { "id": "HMDB0000305", "database": "HMDB Metabolite", "url": "" }, { "id": "C00473", "database": "COMPOUND", "url": "" }, { "id": "4053", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "17336", "database": "ChEBI", "url": "" }, { "id": "8144182", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000003831417", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A493UA87", "gene_name": "AKR1B1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.21", "activity": "L-arabinitol + NADP(+) = L-arabinose + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + NADPH + H(+).", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "A0A493UA87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A493UA87" } ] } ] }, { "uniprot_ac": "A0AAF6YUM7", "gene_name": "RDH8", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "A0AAF6YUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUM7" } ] } ] }, { "uniprot_ac": "E1BM93", "gene_name": "RDH11", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "E1BM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM93" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "E1BM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM93" } ] } ] }, { "uniprot_ac": "F1MD39", "gene_name": "RDH12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "F1MD39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD39" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "F1MD39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD39" } ] } ] }, { "uniprot_ac": "F1N334", "gene_name": "DHRS3", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334" } ] } ] }, { "uniprot_ac": "O77769", "gene_name": "DHRS3", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "O77769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77769" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "O77769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77769" } ] } ] }, { "uniprot_ac": "P16116", "gene_name": "AKR1B1", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.21", "activity": "L-arabinitol + NADP(+) = L-arabinose + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.372", "activity": "glycerol + NADP(+) = L-glyceraldehyde + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + NADPH + H(+).", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.21", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] }, { "ec_number": "1.1.1.372", "activity": "", "evidence": [ { "id": "P16116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P16116" } ] } ] }, { "uniprot_ac": "P59837", "gene_name": "RDH12", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "P59837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P59837" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "P59837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P59837" } ] } ] }, { "uniprot_ac": "Q17QW3", "gene_name": "RDH14", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q17QW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW3" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q17QW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QW3" } ] } ] }, { "uniprot_ac": "Q8HZT6", "gene_name": "RDH10", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q8HZT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZT6" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8HZT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZT6" } ] } ] }, { "uniprot_ac": "Q8SPU8", "gene_name": "DHRS4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + NADPH + H(+).", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8SPU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU8" } ] } ] }, { "uniprot_ac": "Q9N126", "gene_name": "RDH8", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "Q9N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N126" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q9N126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N126" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N334-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 302, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N334-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N334" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N334" }, { "id": "SM00822", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00822" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ketoreductase", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 221, "start_aa": "Glu", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.300", "ec_name": "all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+).", "evidence": [ { "id": "1.1.1.300", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300" }, { "id": "1.1.1.300", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.300" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QQ80-1", "uniprot_ac": "F6QQ80", "uniprot_id": "F6QQ80_BOVIN", "mass": { "chemical_mass": 30862.0, "monoisotopic_mass": 30862.0 }, "refseq": {}, "gene_names": [ { "name": "OLR1", "type": "recommended", "evidence": [ { "id": "F6QQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ] } ], "protein_names": [ { "name": "Oxidized low-density lipoprotein receptor 1", "type": "recommended", "evidence": [ { "id": "F6QQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QQ80/entry#names_and_taxonomy" } ] }, { "name": "Lectin-like oxidized LDL receptor 1", "type": "synonym", "evidence": [ { "id": "F6QQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QQ80/entry#names_and_taxonomy" } ] }, { "name": "Lectin-type oxidized LDL receptor 1", "type": "synonym", "evidence": [ { "id": "F6QQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QQ80/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OLR1", "url": "https://www.uniprot.org/uniprotkb/F6QQ80", "locus": { "chromosome": "5", "start_pos": 99814711, "end_pos": 99803819, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004547", "url": "https://www.ensembl.org/id/ENSBTAG00000004547" } ] } } ], "crossref": [ { "id": "F6QQ80", "url": "https://alphafold.ebi.ac.uk/entry/F6QQ80", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47298:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47298:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RXU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QQ80-1", "url": "https://www.uniprot.org/uniprotkb/F6QQ80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQTIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ", "length": 270, "header": "tr|F6QQ80-1|F6QQ80_BOVIN Isoform 1 of Oxidized low-density lipoprotein receptor 1 OS=Bos taurus OX=9913 GN=OLR1 PE=4 SV=1 CANONICAL=F6QQ80-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXU2/entry", "sequence": { "sequence": "MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELV", "length": 185, "header": "tr|A0AAA9RXU2-1|F6QQ80_BOVIN Computationally mapped isoform of Oxidized low-density lipoprotein receptor 1 OS=Bos taurus OX=9913 GN=OLR1 PE=4 SV=1 CANONICAL=F6QQ80-1" }, "locus": { "chromosome": "5", "start_pos": 99813950, "end_pos": 99803853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129849.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129849.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078350.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078350.1" } ] } }, { "isoform_ac": "A0AAA9SEZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEZ5/entry", "sequence": { "sequence": "MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGIHPANNCPFQFPLLDGVVNEETQLLVALGRWYSFDAPLV", "length": 177, "header": "tr|A0AAA9SEZ5-1|F6QQ80_BOVIN Computationally mapped isoform of Oxidized low-density lipoprotein receptor 1 OS=Bos taurus OX=9913 GN=OLR1 PE=4 SV=1 CANONICAL=F6QQ80-1" }, "locus": { "chromosome": "5", "start_pos": 99813950, "end_pos": 99803853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113179.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113179.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081002.1" } ] } }, { "isoform_ac": "F6QQ80-1", "url": "https://www.uniprot.org/uniprotkb/F6QQ80/entry", "sequence": { "sequence": "MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQTIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ", "length": 270, "header": "tr|F6QQ80-1|F6QQ80_BOVIN Isoform 1 of Oxidized low-density lipoprotein receptor 1 OS=Bos taurus OX=9913 GN=OLR1 PE=4 SV=1 CANONICAL=F6QQ80-1" }, "locus": { "chromosome": "5", "start_pos": 99814089, "end_pos": 99803853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005975.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005975.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005975.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005975.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F6QQ80", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QQ80" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 261, "start_aa": "His", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 208, "end_pos": 210 }, { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1R4-1", "uniprot_ac": "F1N1R4", "uniprot_id": "F1N1R4_BOVIN", "mass": { "chemical_mass": 109149.0, "monoisotopic_mass": 109149.0 }, "refseq": { "ac": "XP_024855878", "name": "exosome complex exonuclease RRP44 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855878" }, "gene_names": [ { "name": "DIS3", "type": "recommended", "evidence": [ { "id": "F1N1R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ] }, { "name": "DIS3", "type": "synonym", "evidence": [ { "id": "XP_024855878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855878" } ] } ], "protein_names": [ { "name": "Exosome complex exonuclease RRP44", "type": "recommended", "evidence": [ { "id": "F1N1R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R4/entry#names_and_taxonomy" } ] }, { "name": "Protein DIS3 homolog", "type": "synonym", "evidence": [ { "id": "F1N1R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R4/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal RNA-processing protein 44", "type": "synonym", "evidence": [ { "id": "F1N1R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R4/entry#names_and_taxonomy" } ] }, { "name": "exosome complex exonuclease RRP44 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024855878", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855878" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIS3", "url": "https://www.uniprot.org/uniprotkb/F1N1R4", "locus": { "chromosome": "12", "start_pos": 47506720, "end_pos": 47532835, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019889", "url": "https://www.ensembl.org/id/ENSBTAG00000019889" } ] } } ], "crossref": [ { "id": "F1N1R4", "url": "https://alphafold.ebi.ac.uk/entry/F1N1R4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019889", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019889", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09862", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09862", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767887", "url": "https://www.ncbi.nlm.nih.gov/gene/767887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767887", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767887", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQVMRNN", "url": "https://omabrowser.org/oma/group/GQVMRNN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1R4", "url": "https://www.orthodb.org/?gene=F1N1R4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23355:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23355:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13638", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13638", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17215", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17215", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17216", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17216", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17849", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17849", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-429958", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429958", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450385", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450385", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450513", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450513", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9930044", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855878", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855878", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R4-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGASGCAVCDGAHEGPVLELQPLDRASSLCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDMTNNQEKHFYTFTNEHHRETYVEQLQGENSNDRNDRAIRVAAKWYNEHLKNMSAENRLQVIFITNDRKNKEKAIEEGIPAFTCEEYIKSLTANPELIDRLACLSEEGNEIESGKTIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWVHSDDEDNKEILLQGLKNLNRAIHEDIVAVELLPKHQWVAPSSVVLQDEGQNEDDIEKEEERECILKTAVNEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAVDGWPRNSRYPNGHFVKNLGEVGDKETETEVLLLEHDVPHQAFSQAVLSFLPKMPWSITEKDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMTHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDNITTSLRGLNKLAKILKKGRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAAKSKNLEIKTDTAKALADSLDQADSPIFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLADLCKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPRLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISVSADTSNMDINEPERKKKKLQK", "length": 958, "header": "tr|F1N1R4-1|F1N1R4_BOVIN Isoform 1 of Exosome complex exonuclease RRP44 OS=Bos taurus OX=9913 GN=DIS3 PE=3 SV=3 CANONICAL=F1N1R4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX8/entry", "sequence": { "sequence": "MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGASGCAVCDGAHEGPVLELQPLDRASSLCPQPHYLLPDTNVLLHQILVWRPGTWASVASCLRPSGSLETYVEQLQGENSNDRNDRAIRVAAKWYNEHLKNMSAENRLQVIFITNDRKNKEKAIEEGIPAFTCEEYIKSLTANPELIDRLACLSEEGNEIESGKTIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWVHSDDEDNKEILLQGLKNLNRAIHEDIVAVELLPKHQWVAPSSVVLQDEGQNEDDIEKEEERECILKTAVNEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAVDGWPRNSRYPNGHFVKNLGEVGDKETETEVLLLEHDVPHQAFSQAVLSFLPKMPWSITEKDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMTHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDNITTSLRGLNKLAKILKKGRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAAKSKNLEIKTDTAKALADSLDQADSPIFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLADLCKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPRLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISVSADTSNMDINEPERKKKKLQK", "length": 927, "header": "tr|A0AAA9RXX8-1|F1N1R4_BOVIN Computationally mapped isoform of Exosome complex exonuclease RRP44 OS=Bos taurus OX=9913 GN=DIS3 PE=3 SV=1 CANONICAL=F1N1R4-1" }, "locus": { "chromosome": "12", "start_pos": 47532636, "end_pos": 47507724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102041.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102041.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078393.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078393.1" } ] } }, { "isoform_ac": "F1N1R4-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R4/entry", "sequence": { "sequence": "MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGASGCAVCDGAHEGPVLELQPLDRASSLCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDMTNNQEKHFYTFTNEHHRETYVEQLQGENSNDRNDRAIRVAAKWYNEHLKNMSAENRLQVIFITNDRKNKEKAIEEGIPAFTCEEYIKSLTANPELIDRLACLSEEGNEIESGKTIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWVHSDDEDNKEILLQGLKNLNRAIHEDIVAVELLPKHQWVAPSSVVLQDEGQNEDDIEKEEERECILKTAVNEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAVDGWPRNSRYPNGHFVKNLGEVGDKETETEVLLLEHDVPHQAFSQAVLSFLPKMPWSITEKDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMTHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDNITTSLRGLNKLAKILKKGRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAAKSKNLEIKTDTAKALADSLDQADSPIFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLADLCKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPRLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISVSADTSNMDINEPERKKKKLQK", "length": 958, "header": "tr|F1N1R4-1|F1N1R4_BOVIN Isoform 1 of Exosome complex exonuclease RRP44 OS=Bos taurus OX=9913 GN=DIS3 PE=3 SV=3 CANONICAL=F1N1R4-1" }, "locus": { "chromosome": "12", "start_pos": 47532636, "end_pos": 47507724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026500.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026500.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026500.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026500.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767887", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767887", "resource": "KEGG Pathway" }, { "id": "R-BTA-429958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429958", "resource": "Reactome", "description": "mRNA decay by 3' to 5' exoribonuclease" }, { "id": "R-BTA-450385", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450385", "resource": "Reactome", "description": "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" }, { "id": "R-BTA-450513", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450513", "resource": "Reactome", "description": "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" }, { "id": "R-BTA-450604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450604", "resource": "Reactome", "description": "KSRP (KHSRP) binds and destabilizes mRNA" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-9930044", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "resource": "Reactome", "description": "Nuclear RNA decay" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QQU7-1", "protein_name": "Exosome complex exonuclease RRP44", "gene_name": "DIS3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPVLEPQPLDPASSLCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQQQGENSNDRNDRAIRVAAKWYNEHLKKMSAENQLQVIFITNDRKNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSDEGNEIESGKVIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWVHGDTEENKEIILQGLKNLNRAVHEDIVAVELLPKNQWVAPSSVVLHDEGQNEDDVEKEEERERILKTAVNEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVSIDGWPRNSRYPNGHFVKNLGEVGDKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELENGDLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDSITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAAKSKNLEIKTDTAKALADSLDRVDSPIFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLADLCKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPKPRLIYDDEVPSLKIEDTVFHIFDKVKVRIMLDSSNLQHQKIRMLLVEPQIPGISVPTDTSNMDNSEPERKKKKLQK", "length": 958 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7EPZ4-1", "protein_name": "Exosome complex exonuclease RRP44", "gene_name": "Dis3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSAAARRLARPVARRTRARPWSCSPGTRRAASAHGRTTSCRTPMCCCTRCVDAGPRGDEGAWREGRRVSGWRGKFFGHPRFQLSRPGYLSLTLLHLLVVFGSWSRTFRHVNFLTPGVSSTLDYKCLEAGDLGFCGLQIATPRQLIDVLEDPAIRNVIVLQTVLQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNEHHKETYIEQEQGENANDRNDRAIRVAAKWYNEHLKMSAENQLQVILITNDKKNKEKAAEEGIPAFTCEEYVKSLTANPELIDRLACLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEDEKEILIQGLKHLNRAIHEDIVAVELLPKSQWVAPSSVVLHDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNKLAKILKRGRIEKGALTLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEVLVKAAKSKNLEIRTDTAKSLADSLDRAECPDFPYLNTLLRILATRCMMQAVYFCSGMDSDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLSDICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPKPRLTYDDEIPSLRIEGTVFHVFDKVKVKITLDSSNLQHQKIRMALVEPQIPGINMPPDVSDMDLNGPGGKKRKLEK", "length": 1026 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08162-1", "protein_name": "Exosome complex exonuclease DIS3", "gene_name": "DIS3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSVPAIAPRRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNDRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMDSFDKDLERDTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDIEAGDDDDNNESSSNTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDIDDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK", "length": 1001 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54BH9-1", "protein_name": "Ribosomal RNA-processing protein 44", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQSNKCFYKATKKGTIIKVVNEIYLRDDIPCGHDSCKECKIKLERRTTVEDRALLSNEINTIDSDKILILDTNVILHQIDLLEDPTIKNCIILSTVLDEVKSQNRAIFNRIRDVIKESSRKFYVYSNEYSTFTSITRENGESPNDRNDRAIRVATQWYKSHLHKYSIKVLLITNDKDNLKKAKSLGLDCQTIQDLVFELSDKNPSLVDKLSDPNDDSNEKDNDESKRFQYQEHKPMSMLTEGIKGGKLIQGIFRTSITNYREATVSNREMEKEILIQGIENINRAVDGDIVAVELFDQSKWNTPSTLIMLENEGVEEDDDSIAKDSLISKKQPTGKVVGIIKRNWKPYCGAVEFKQDDNNTTTKTSTGLHFLYFMPIDKRIPKIRIKSRQVSNLIGKRIVVAIDQWDKNSKYPSGHFVKDLGPLGDKETESQVLLLQFDIPHHPFGAAVMKCLPSPDIMDRVTSADMVGRKDLRKECIFSVDPPGCTDIDDALHIKDLGKGIMEVGVHIADVSHFVQEGTAIDEEAANRSTSVYLVDRRIDMLPGELSGNLCSLMSNVDRFAFSCIWKINQHTGEIIAVEYTKSIIRSCASLTYEQAQIRIDDKSQNDQITVNLRNLNSLAKILRKQRFDRGALYLASPQVKFKTEELGGDPSDVEIYQLRETNSMIEEFMLLANIWVAKKIYKHFPGCAMLRRHPTPNKAAFDLLTKLIENKGYKFSTTTSKDLADSLDSAVDKNDSYFNTLCRIMTTRCMSPAKYFSSGSLPYEDFNHYGLATDIYTHFTSPIRRYPDIIVHRLLASAIGIQSVSLNLENKTISALTENNNFRHKMAQYASRGSTQLHTLIFFKGRKSVEDAYIIRVKANAFVVLVPRYGFEGTVYVSDPNSSTATTNGGGGTSNIYNYNHEDQTLGNGIHTFRVFDKVTVEIYVDDSKAHDQKLKINCINPNISFVPSDDIDSNNLDDILNQENNINKSTSSTSSSNKSSKVRKQPENIKSSTKPTSNKKLKK", "length": 1006 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CSH3-1", "protein_name": "Exosome complex exonuclease RRP44", "gene_name": "Dis3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRSKTFLKKTRAGGVVKIVREHYLRDDIGCGAPACSACGGAHAGPALELQPRDQASSLCPWPHYLLPDTNVLLHQIDVLEHPAIRNVIVLQTVMQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNEHHKETYIEQEQGENANDRNDRAIRVAAKWYNEHLKRVAADSQLQVILITNDRKNKEKAVQEGIPAFTCEEYVKSLTANPELIDRLAYLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGALTLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYDILVKAAKSKNLQIKTDTAKSLADSLDRAESPDFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLSDICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPKPRLAYDDEIPSLRIEGTVFHVFDKVKVKITLDSSNLQHQKIRMALVEPQIPGINIPPNVADKALTAPGGKKRKLEK", "length": 958 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SHL7-1", "protein_name": "Exosome complex exonuclease RRP44 homolog A", "gene_name": "RRP44A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLQSKVFNKKTRGGRIQKQVREVYLRDDIYCGAFSCKSCDSSAARLSSSKIIVVDTNVVLHQIDLLENKAIDTVVVLSVVLDEVKNRNRSVYNRIRLLCSNPARQFYVFSNHVHKDTYVQAMEKESANDHNDRAIRVATLWYQKHLGDTSQVLLVTNDRENKRKATEEGISAETIEAYVKSLGQPELLDLLAQPTNEDITMEDADDSRPSKRKLIYQEHKPMSEITAGLHRGIYHQGKLRVNRFNPYEAYVGSESIGEEIIIYGRSNMNRAFDGDIVAVELLPRDQWQDEKALSIAEEDDEEDDTVHLAPDNVDDAPRTSNLSHETSGDKNAAPVRPSGRVVGVIRRNWHSYCGSLEPMSLPAGSGGTAHALFVSKDRRIPKIRINTRQLQNLLDMRIVVAVDSWDRQSRYPSGHYVRPIGKIGDKETETEVVLIENDVDYSPFSSQVLACLPPLPWSVSSEDVSNPVRQDLRHLLVFSVDPPGCKDIDDALHCTSLPNGNFELGVHIADVTNFVHPGTPLDDEASKRGTSVYLVERRIDMLPKPLTEDICSLRADVERLAFSVIWEMSPDAEIISTRFTKSIIKSSAALSYIEAQARMDDSRLTDSLTTDLRNMNTLAKIMRQRRIDRGALTLASAEVKFDIDPENHDPLNIGMYQILEANQMVEEFMLAANVSVAGQILKLFPSCSLLRRHPTPTREMLEPLLRTAAAIGLTLDVSSSKALADSLDRAVGEDPYFNKLIRILATRCMTQAVYFCSGDLSPPEYHHYGLAAPLYTHFTSPIRRYADVFVHRLLAASLGIYKLPTVFQDRPQLTSVADNLNYRHRNAQMAGRASVELYVLIYFRTRPTDEEARVVKIRSNGFIVFVPKYGIEGPVYLTGKGEKGAGDWYVDEEKQKIVKMDGSLSYSVLQTVKIHMEVVEPQPNRPKLQLTLL", "length": 933 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VC93-1", "protein_name": "Exosome complex exonuclease RRP44", "gene_name": "Dis3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQTLREFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVSAAPPSKKTKKDKKKK", "length": 982 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y2L1-1", "protein_name": "Exosome complex exonuclease RRP44", "gene_name": "DIS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK", "length": 958 }, "evidence": [ { "id": "F1N1R4", "url": "https://omabrowser.org/oma/group/F1N1R4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "3'-5'-RNA exonuclease activity", "id": "GO:0000175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000175", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "nuclear exosome (RNase complex)", "id": "GO:0000176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000176", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "cytoplasmic exosome (RNase complex)", "id": "GO:0000177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000177", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process", "id": "GO:0000956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000956", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "rRNA catabolic process", "id": "GO:0016075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016075", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "CUT catabolic process", "id": "GO:0071034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071034", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" }, { "name": "nuclear mRNA surveillance of mRNA 3'-end processing", "id": "GO:0071031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071031", "evidence": [ { "database": "UniProtKB", "id": "F1N1R4", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 605, "end_pos": 607, "annotation": "n_glycosylation_sequon" }, { "start_pos": 671, "end_pos": 673, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1R4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 958, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1R4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1R4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" }, { "id": "SM00670", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00670" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIN", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 182, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R4" }, { "id": "SM00955", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00955" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RNB", "eco_id": "ECO_0000259", "start_pos": 467, "end_pos": 797, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 605, "end_pos": 607 }, { "start_pos": 671, "end_pos": 673 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4C6-1", "uniprot_ac": "F1N4C6", "uniprot_id": "F1N4C6_BOVIN", "mass": { "chemical_mass": 39457.0, "monoisotopic_mass": 39457.0 }, "refseq": {}, "gene_names": [ { "name": "BHMT2", "type": "recommended", "evidence": [ { "id": "F1N4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ] } ], "protein_names": [ { "name": "Betaine--homocysteine S-methyltransferase 2", "type": "synonym", "evidence": [ { "id": "F1N4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the regulation of homocysteine metabolism.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RZ93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ93#function" }, { "database": "UniProtKB", "id": "PIRNR037505", "url": "https://www.uniprot.org/uniprotkb/PIRNR037505#function" }, { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BHMT2", "url": "https://www.uniprot.org/uniprotkb/F1N4C6", "locus": { "chromosome": "10", "start_pos": 10158404, "end_pos": 10142588, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038234", "url": "https://www.ensembl.org/id/ENSBTAG00000038234" } ] } } ], "crossref": [ { "id": "F1N4C6", "url": "https://alphafold.ebi.ac.uk/entry/F1N4C6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038234", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038234", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46120", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46120", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46120:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46120:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1614635", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614635", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "22336", "url": "https://www.rhea-db.org/rhea/22336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZ93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4C6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4C6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPIEGPRVKKGLLEHLDSGEVVVGDGSFLLTLEKRGYVKAGLWTPEAVVEHPNAVRQLHMEFLRVGSDVMQTFTFSASENNMESLWEAVNTAACDLAREGANKGDALVAGGICRTSLYAHHKDEVRIKKLFRLQLEIFARKNVDFLIAEYFEHAVEVLKESGEPVAATMCIGPEGDMHGVTPGECAVKLVKAGASVVGVNCRFGPWTSLKTMSLMKEARQAAELKAPLMVWSLGFHMPDCGKGGFLDLPEYPFVLEPRVATRWDIQKNAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPEKGFLSPASEKHGSWGSGLNMHTKPWIRARARREYWENLRLASGRPFCPSLSKPDA", "length": 357, "header": "tr|F1N4C6-1|F1N4C6_BOVIN Isoform 1 of Betaine--homocysteine S-methyltransferase 2 OS=Bos taurus OX=9913 GN=BHMT2 PE=4 SV=4 CANONICAL=F1N4C6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZ93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ93/entry", "sequence": { "sequence": "MAPIEGPRVKKGLLEHLDSGEVVVGDGSFLLTLEKRGYVKAGLWTPEAVVEHPNAVRQLHMEFLRVGSDVMQTFTFSASENNMESLYFEHAVEVLKESGEPVAATMCIGPEGDMHGVTPGECAVKLVKAGASVVGVNCRFGPWTSLKTMSLMKEARQAAELKAPLMVWSLGFHMPDCGKGGFLDLPEYPFVLEPRVATRWDIQKNAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPEKGFLSPASEKHGSWGSGLNMHTKPWIRARARREYWENLRLASGRPFCPSLSKPDA", "length": 293, "header": "tr|A0AAA9RZ93-1|F1N4C6_BOVIN Computationally mapped isoform of Betaine--homocysteine S-methyltransferase 2 OS=Bos taurus OX=9913 GN=BHMT2 PE=4 SV=1 CANONICAL=F1N4C6-1" }, "locus": { "chromosome": "10", "start_pos": 10158401, "end_pos": 10142912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117452.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117452.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077962.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077962.1" } ] } }, { "isoform_ac": "F1N4C6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4C6/entry", "sequence": { "sequence": "MAPIEGPRVKKGLLEHLDSGEVVVGDGSFLLTLEKRGYVKAGLWTPEAVVEHPNAVRQLHMEFLRVGSDVMQTFTFSASENNMESLWEAVNTAACDLAREGANKGDALVAGGICRTSLYAHHKDEVRIKKLFRLQLEIFARKNVDFLIAEYFEHAVEVLKESGEPVAATMCIGPEGDMHGVTPGECAVKLVKAGASVVGVNCRFGPWTSLKTMSLMKEARQAAELKAPLMVWSLGFHMPDCGKGGFLDLPEYPFVLEPRVATRWDIQKNAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPEKGFLSPASEKHGSWGSGLNMHTKPWIRARARREYWENLRLASGRPFCPSLSKPDA", "length": 357, "header": "tr|F1N4C6-1|F1N4C6_BOVIN Isoform 1 of Betaine--homocysteine S-methyltransferase 2 OS=Bos taurus OX=9913 GN=BHMT2 PE=4 SV=4 CANONICAL=F1N4C6-1" }, "locus": { "chromosome": "10", "start_pos": 10158401, "end_pos": 10142912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048928.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048928.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045884.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045884.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 182, "start_aa": "Thr", "end_pos": 182, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr182", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1614635", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614635", "resource": "Reactome", "description": "Sulfur amino acid metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "S-methyltransferase activity", "id": "GO:0008172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008172", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "betaine-homocysteine S-methyltransferase activity", "id": "GO:0047150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047150", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "S-methylmethionine-homocysteine S-methyltransferase activity", "id": "GO:0061627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061627", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "methionine biosynthetic process", "id": "GO:0009086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009086", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "S-methylmethionine metabolic process", "id": "GO:0033477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033477", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "S-adenosylmethionine metabolic process", "id": "GO:0046500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046500", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" }, { "name": "L-methionine salvage", "id": "GO:0071267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071267", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N4C6", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22336", "name": "", "equation": "L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I597-1" ], "evidence": [ { "id": "22336", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22336" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q5I597", "gene_name": "BHMT", "activity": [ { "ec_number": "2.1.1.5", "activity": "L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine.", "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ] }, { "ec_number": "2.1.1.5", "activity": "", "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4C6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 357, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4C6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4C6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" }, { "id": "PS50970", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50970" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Hcy-binding", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 299, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" }, { "id": "PIRSR037505-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037505-2" } ], "binding_site_uniprot": 138, "amino_acid": "Ile", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 138, "end_pos": 138, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" }, { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" }, { "id": "PIRSR037505-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037505-2" } ], "binding_site_uniprot": 202, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 202, "end_pos": 202, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" }, { "id": "PIRSR037505-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037505-2" } ], "binding_site_uniprot": 220, "amino_acid": "Arg", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 220, "end_pos": 220, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" }, { "id": "PIRSR037505-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037505-2" } ], "binding_site_uniprot": 221, "amino_acid": "Gln", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 221, "end_pos": 221, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" }, { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" }, { "id": "PIRSR037505-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037505-2" } ], "binding_site_uniprot": 284, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 284, "end_pos": 284, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4C6" }, { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" }, { "id": "PIRSR037505-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037505-2" } ], "binding_site_uniprot": 285, "amino_acid": "Cys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 285, "end_pos": 285, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 182 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4N8-1", "uniprot_ac": "F1N4N8", "uniprot_id": "F1N4N8_BOVIN", "mass": { "chemical_mass": 20732.0, "monoisotopic_mass": 20732.0 }, "refseq": { "ac": "NP_001192698", "name": "cerebral dopamine neurotrophic factor precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192698" }, "gene_names": [ { "name": "CDNF", "type": "recommended", "evidence": [ { "id": "F1N4N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ] }, { "name": "ARMETL1", "type": "synonym", "evidence": [ { "id": "NP_001192698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192698" } ] }, { "name": "CDNF", "type": "synonym", "evidence": [ { "id": "NP_001192698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192698" } ] } ], "protein_names": [ { "name": "Cerebral dopamine neurotrophic factor", "type": "synonym", "evidence": [ { "id": "F1N4N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N8/entry#names_and_taxonomy" } ] }, { "name": "arginine-rich, mutated in early stage tumors-like 1", "type": "synonym", "evidence": [ { "id": "NP_001192698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192698" } ] }, { "name": "cerebral dopamine neurotrophic factor precursor", "type": "synonym", "evidence": [ { "id": "NP_001192698", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192698" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDNF", "url": "https://www.uniprot.org/uniprotkb/F1N4N8", "locus": { "chromosome": "13", "start_pos": 29470661, "end_pos": 29492703, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016450", "url": "https://www.ensembl.org/id/ENSBTAG00000016450" } ] } } ], "crossref": [ { "id": "F1N4N8", "url": "https://alphafold.ebi.ac.uk/entry/F1N4N8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016450", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016450", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513798", "url": "https://www.ncbi.nlm.nih.gov/gene/513798", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513798", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513798", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSWGEVC", "url": "https://omabrowser.org/oma/group/DSWGEVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4N8", "url": "https://www.orthodb.org/?gene=F1N4N8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12990", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12990", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12990:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12990:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192698", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4N8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4N8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWCGGAAAMVAFCAGLWVSNPGRAQGQEAGGIPGADCEVCQEFLSRFYNSLIARGVNFSLDTIEKELINFCLDVKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAAKICEKLKKMDSQICELKYEKKLDLASVDLSKMRVAELKQILHSWGEECRACAEKTDYVNLIKELAPKYAATHPQTEL", "length": 187, "header": "tr|F1N4N8-1|F1N4N8_BOVIN Isoform 1 of Cerebral dopamine neurotrophic factor OS=Bos taurus OX=9913 GN=CDNF PE=3 SV=2 CANONICAL=F1N4N8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E4/entry", "sequence": { "sequence": "DAGSTNGWFPNSNSAGPRHSPIKHRGDFTFQSTHYASALAEAARVAANQREGPAFSVAQSAISYLCQEFLSRFYNSLIARGVNFSLDTIEKELINFCLDVKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAAKICEKLKKMDSQICELKYEKKLDLASVDLSKMRVAELKQILHSWGEECRACAEKTDYVNLIKELAPKYAATHPQTEL", "length": 213, "header": "tr|A0AAA9S0E4-1|F1N4N8_BOVIN Computationally mapped isoform of Cerebral dopamine neurotrophic factor OS=Bos taurus OX=9913 GN=CDNF PE=3 SV=1 CANONICAL=F1N4N8-1" }, "locus": { "chromosome": "13", "start_pos": 29492701, "end_pos": 29472852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135819.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135819.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075530.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075530.1" } ] } }, { "isoform_ac": "F1N4N8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4N8/entry", "sequence": { "sequence": "MWCGGAAAMVAFCAGLWVSNPGRAQGQEAGGIPGADCEVCQEFLSRFYNSLIARGVNFSLDTIEKELINFCLDVKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAAKICEKLKKMDSQICELKYEKKLDLASVDLSKMRVAELKQILHSWGEECRACAEKTDYVNLIKELAPKYAATHPQTEL", "length": 187, "header": "tr|F1N4N8-1|F1N4N8_BOVIN Isoform 1 of Cerebral dopamine neurotrophic factor OS=Bos taurus OX=9913 GN=CDNF PE=3 SV=2 CANONICAL=F1N4N8-1" }, "locus": { "chromosome": "13", "start_pos": 29492247, "end_pos": 29472852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021871.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021871.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021871.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021871.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513798", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513798", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GVR5-1", "protein_name": "Cerebral dopamine neurotrophic factor", "gene_name": "Cdnf", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRCTSPAILVTFCALLWISNLVQAQDQDTDTQLEADCEVCKAFLNRFYNSLLTRGVDFSVDTIEEELASFCLDAKGKESHLCYYLGASKDSATKILGEVTRPLSVHVPIVKICERLKKMNSQICKLNYEKKLDLASVDLWKMRDAELKQILHSWGEECRACAEKNDYVNLIKELAPKYVEIHPQIEL", "length": 187 }, "evidence": [ { "id": "F1N4N8", "url": "https://omabrowser.org/oma/group/F1N4N8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0C5I0-1", "protein_name": "Cerebral dopamine neurotrophic factor", "gene_name": "Cdnf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRCTSPAALVTFCAGLWISNHVLAQGLEAGVRSRADCEVCKEFLNRFYNSLLTRGIDFSVDTIEEELISFCADTKGKENRLCYYLGATKDSATKILGEVTRPMSVHMPTVKICEKLKKMDSQICELKYEKKLDLESVDLWKMRVAELKQILHSWGEECRACAEKHDYVNLIKELAPKYVETRPQTEL", "length": 187 }, "evidence": [ { "id": "F1N4N8", "url": "https://omabrowser.org/oma/group/F1N4N8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q49AH0-1", "protein_name": "Cerebral dopamine neurotrophic factor", "gene_name": "CDNF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAATHPKTEL", "length": 187 }, "evidence": [ { "id": "F1N4N8", "url": "https://omabrowser.org/oma/group/F1N4N8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CC36-1", "protein_name": "Cerebral dopamine neurotrophic factor", "gene_name": "Cdnf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRCISPTALVTFCAGFCISNPVLAQGLEAGVGPRADCEVCKEFLDRFYNSLLSRGIDFSADTIEKELLNFCSDAKGKENRLCYYLGATTDAATKILGEVTRPMSVHIPAVKICEKLKKMDSQICELKYGKKLDLASVDLWKMRVAELKQILQRWGEECRACAEKSDYVNLIRELAPKYVEIYPQTEL", "length": 187 }, "evidence": [ { "id": "F1N4N8", "url": "https://omabrowser.org/oma/group/F1N4N8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ], "pmid": "" }, { "name": "dopaminergic neuron differentiation", "id": "GO:0071542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071542", "evidence": [ { "database": "UniProtKB", "id": "F1N4N8", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4N8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 187, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4N8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4N8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" }, { "id": "PF10208", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10208" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ARMET C-terminal", "eco_id": "ECO_0000259", "start_pos": 136, "end_pos": 178, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4N8" }, { "id": "PF20145", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ARMET N-terminal", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 132, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5I1-1", "uniprot_ac": "F1N5I1", "uniprot_id": "F1N5I1_BOVIN", "mass": { "chemical_mass": 41428.0, "monoisotopic_mass": 41428.0 }, "refseq": {}, "gene_names": [ { "name": "CD1E", "type": "recommended", "evidence": [ { "id": "F1N5I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ] } ], "protein_names": [ { "name": "CD1e molecule", "type": "synonym", "evidence": [ { "id": "F1N5I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD1E", "url": "https://www.uniprot.org/uniprotkb/F1N5I1", "locus": { "chromosome": "3", "start_pos": 11606523, "end_pos": 11610099, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009421", "url": "https://www.ensembl.org/id/ENSBTAG00000009421" } ] } } ], "crossref": [ { "id": "F1N5I1", "url": "https://alphafold.ebi.ac.uk/entry/F1N5I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009421", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009421", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21029", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21029", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5I1", "url": "https://www.orthodb.org/?gene=F1N5I1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675:SF146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675:SF146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16497", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16497", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S0X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5I1-1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLLLPLLPLLFKGLLCHGASIVGLQVPGPHHVAAEESPSFRLIQISSFANHSWTKTQGSGWLGDLQTHGWDSVLASIRFLRPWAQGNFSKEELKNIQAFLQLYLHSFPREVQAYASQFQFEYPFELQVSFGCLIHSGKALETFLNGAYQGLDFLSFQENSWKSSPEAGSRAENVCKVLNHYRVIKEIVQRLLSDTCPRFLAGVLEAGKAELEKQVKPEAWVSKGPSPGPGRLLLVCHVSGFHPKPIWVMWMRGKQKHPGTRRGDVLPNADGTWYLRVTLDVAAGEAAGLSCQVKHSSLGGQDIIIHWGGYSVFWILICLIVIVTLVMLVIVDSLFKKQRSQNPRPQEFRTSALLGTGIMDQKQTLKEMES", "length": 371, "header": "tr|F1N5I1-1|F1N5I1_BOVIN Isoform 1 of CD1e molecule OS=Bos taurus OX=9913 GN=CD1E PE=4 SV=2 CANONICAL=F1N5I1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0X8/entry", "sequence": { "sequence": "MLLLLPLLPLLFKGLLCHGASIVDPFELQVSFGCLIHSGKALETFLNGAYQGLDFLSFQENSWKSSPEAGSRAENVCKVLNHYRVIKEIVQRLLSDTCPRFLAGVLEAGKAELEKQVKPEAWVSKGPSPGPGRLLLVCHVSGFHPKPIWVMWMRGKQKHPGTRRGDVLPNADGTWYLRVTLDVAAGEAAGLSCQVKHSSLGGQDIIIHWGGYSVFWILICLIVIVTLVMLVIVDSLFKKQSSNQDVFSISHPAFPIGAKTQDPRNSGHQLCLAQESWIKNKLLKKWKARLNQLC", "length": 294, "header": "tr|A0AAA9S0X8-1|F1N5I1_BOVIN Computationally mapped isoform of CD1e molecule OS=Bos taurus OX=9913 GN=CD1E PE=4 SV=1 CANONICAL=F1N5I1-1" }, "locus": { "chromosome": "3", "start_pos": 11610046, "end_pos": 11607202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130081.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130081.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075732.1" } ] } }, { "isoform_ac": "A0AAA9SPD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPD0/entry", "sequence": { "sequence": "MLLLLPLLPLLFKGLLCHGASIVVKPEAWVSKGPSPGPGRLLLVCHVSGFHPKPIWVMWMRGKQKHPGTRRGDVLPNADGTWYLRVTLDVAAGEAAGLSCQVKHSSLGGQDIIIHWGGYSVFWILICLIVIVTLVMLVIVDSLFKKQSSNQDVFSISHPAFPIGAKTQDPRNSGHQLCLAQESWIKNKLLKKWKARLNQLC", "length": 201, "header": "tr|A0AAA9SPD0-1|F1N5I1_BOVIN Computationally mapped isoform of CD1e molecule OS=Bos taurus OX=9913 GN=CD1E PE=4 SV=1 CANONICAL=F1N5I1-1" }, "locus": { "chromosome": "3", "start_pos": 11610046, "end_pos": 11607202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085782.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085782.1" } ] } }, { "isoform_ac": "F1N5I1-1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1/entry", "sequence": { "sequence": "MLLLLPLLPLLFKGLLCHGASIVGLQVPGPHHVAAEESPSFRLIQISSFANHSWTKTQGSGWLGDLQTHGWDSVLASIRFLRPWAQGNFSKEELKNIQAFLQLYLHSFPREVQAYASQFQFEYPFELQVSFGCLIHSGKALETFLNGAYQGLDFLSFQENSWKSSPEAGSRAENVCKVLNHYRVIKEIVQRLLSDTCPRFLAGVLEAGKAELEKQVKPEAWVSKGPSPGPGRLLLVCHVSGFHPKPIWVMWMRGKQKHPGTRRGDVLPNADGTWYLRVTLDVAAGEAAGLSCQVKHSSLGGQDIIIHWGGYSVFWILICLIVIVTLVMLVIVDSLFKKQRSQNPRPQEFRTSALLGTGIMDQKQTLKEMES", "length": 371, "header": "tr|F1N5I1-1|F1N5I1_BOVIN Isoform 1 of CD1e molecule OS=Bos taurus OX=9913 GN=CD1E PE=4 SV=2 CANONICAL=F1N5I1-1" }, "locus": { "chromosome": "3", "start_pos": 11610046, "end_pos": 11607218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038392.4", "url": "https://www.ensembl.org/id/ENSBTAT00000038392.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038206.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038206.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated cytotoxicity", "id": "GO:0001916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001916", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "antigen processing and presentation, exogenous lipid antigen via MHC class Ib", "id": "GO:0048007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048007", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "antigen processing and presentation, endogenous lipid antigen via MHC class Ib", "id": "GO:0048006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048006", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "endogenous lipid antigen binding", "id": "GO:0030883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030883", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "exogenous lipid antigen binding", "id": "GO:0030884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030884", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" }, { "name": "lipopeptide binding", "id": "GO:0071723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071723", "evidence": [ { "database": "UniProtKB", "id": "F1N5I1", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5I1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 371, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5I1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5I1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5I1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 198, "end_pos": 298, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N322-1", "uniprot_ac": "F1N322", "uniprot_id": "F1N322_BOVIN", "mass": { "chemical_mass": 166941.0, "monoisotopic_mass": 166941.0 }, "refseq": { "ac": "XP_024839009", "name": "nischarin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839009" }, "gene_names": [ { "name": "NISCH", "type": "recommended", "evidence": [ { "id": "F1N322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ] }, { "name": "NISCH", "type": "synonym", "evidence": [ { "id": "XP_024839009", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839009" } ] } ], "protein_names": [ { "name": "Nischarin", "type": "recommended", "evidence": [ { "id": "F1N322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N322/entry#names_and_taxonomy" } ] }, { "name": "Imidazoline receptor 1", "type": "synonym", "evidence": [ { "id": "F1N322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N322/entry#names_and_taxonomy" } ] }, { "name": "Imidazoline-1 receptor", "type": "synonym", "evidence": [ { "id": "F1N322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N322/entry#names_and_taxonomy" } ] }, { "name": "nischarin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839009", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839009" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NISCH", "url": "https://www.uniprot.org/uniprotkb/F1N322", "locus": { "chromosome": "22", "start_pos": 48370388, "end_pos": 48434240, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014779", "url": "https://www.ensembl.org/id/ENSBTAG00000014779" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014779", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014779", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06875", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06875", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100336473", "url": "https://www.ncbi.nlm.nih.gov/gene/100336473", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057288", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057288", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336473", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336473", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WSKNDLC", "url": "https://omabrowser.org/oma/group/WSKNDLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N322", "url": "https://www.orthodb.org/?gene=F1N322", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15454:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15454:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024839009", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839009", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S317", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S317", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S317-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S317-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N322-1", "url": "https://www.uniprot.org/uniprotkb/F1N322-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAARSFGPEREAEPVKTARVVGSELVDTYTVYIIQITDGSHEWTVKHRYSDFHDLHEKLVAEKKIDRSLLPPKKIIGKNSRSLVEKREKDLEIYLQTLLATFPDVAPRVLAQFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDARRIRGLVASKPTLATMSVRFSATSMKEVLVPEASEFDEWEPAGAALEGPVTAVIPTWQALTALDLSHNSISEIDDSVKLIPKIEFLDLSHNGVLVMNNLQHLYNLVHVDLSYNKLSSLEGAHTKLGNIKTLNLAGNLLRHLSGLHKLYSLVNLDLSDNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKVSEDSRLSAAPCVRPSSSPPSAAPTSASLPQPILSNQGIMFVQEDALASSLSSTDSLTPEDRSIVGGCSDSLESIPAGQAPSDDLRDVPGAVGGVSPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEDDEEEEDVAENRYFEMGPPDTEEEEEGGPGEEEEEEEEEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAAHLHEFHADLRACFAPQHMAMLCSPVLYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAPGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKTPATGGGPQSPLVDGQPAESRASSDQNLQEAPAETTAPALVEAPALTPGEASAPSPAKTPAPVEASVPALVPVEVPEEAEASAEIPVEALAQAEAPAQYPSEPLIRSMSEDNQIPSHLPACPSLRHIASLRGRAVVEFFHSSIAEVENEELRHLLWSSVVFYQMPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQVVNVGLFDQYFRLTGSCPAQVVTCLTRDSYLTHCFLQHLMAVLSLLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEVGDLTFTVAQKMAAPEKAPALSILLCVQAFQVGSPQPGRCRGLLRPKTLLLTSAEIFLLDEDFVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARGGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1508, "header": "tr|F1N322-1|F1N322_BOVIN Isoform 1 of Nischarin OS=Bos taurus OX=9913 GN=NISCH PE=4 SV=3 CANONICAL=F1N322-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S317-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S317/entry", "sequence": { "sequence": "MAAAARSFGPEREAEPVKTARVVGSELVDTYTVYIIQITDGSHEWTVKHRYSDFHDLHEKLVAEKKIDRSLLPPKKIIGKNSRSLVEKREKDLEIYLQTLLATFPDVAPRVLAQFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDARRIRGLVASKPTLATMSVRFSATSMKEVLVPEASEFDEWEPAGAALEGPVTAVIPTWQALTALDLSHNSISEIDDSVKLIPKIEFLDLSHNGVLVMNNLQHLYNLVHVDLSYNKLSSLEGAHTKLGNIKTLNLAGNLLRHLSGLHKLYSLVNLDLSDNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKVSEDSRLSAAPCVRPSSSPPSAAPTSASLPQPILSNQGILGDE", "length": 516, "header": "tr|A0AAA9S317-1|F1N322_BOVIN Computationally mapped isoform of Nischarin OS=Bos taurus OX=9913 GN=NISCH PE=4 SV=2 CANONICAL=F1N322-1" }, "locus": { "chromosome": "22", "start_pos": 48432678, "end_pos": 48411842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122749.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122749.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078145.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078145.2" } ] } }, { "isoform_ac": "A0AAA9SBT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT5/entry", "sequence": { "sequence": "MGVGKVVILCPFIQVYIIQITDGSHEWTVKHRYSDFHDLHEKLVAEKKIDRSLLPPKKIIGKNSRSLVEKREKDLEIYLQTLLATFPDVAPRVLAQFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDARRIRGLVASKPTLATMSVRFSATSMKEVLVPEASEFDEWEPAGAALEGPVTAVIPTWQALTALDLSHNSISEIDDSVKLIPKIEFLDLSHNGVLVMNNLQHLYNLVHVDLSYNKLSSLEGAHTKLGNIKTLNLAGNLLRHLSGLHKLYSLVNLDLSDNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKVSEDSRLSAAPCVRPSSSPPSAAPTSASLPQPILSNQGIMFVQEDALASSLSSTDSLTPEDRSIVGGCSDSLESIPAGQAPSDDLRDVPGAVGGVSPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEDDEEEEDVAENRYFEMGPPDTEEEEEGGPGEEEEEEEEEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAAHLHEFHADLRACFAPQHMAMLCSPVLYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAPGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKTPATGGGPQSPLVDGQPAESRASSDQNLQEAPAETTAPALVEAPALTPGEASAPSPAKTPAPVEASVPALVPVEVPEEAEASAEIPVEALAQAEAPAQYPSEPLIRSMSEDNQIPSHLPACPSLRHIASLRGRAVVEFFHSSIAEVENEELRHLLWSSVVFYQMPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQVVNVGLFDQYFRLTGSCPAQVVTCLTRDSYLTHCFLQHLMAVLSLLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEVGDLTFTVAQKMAAPEKAPALSILLCVQAFQVGSPQPGRCRGLLRPKTLLLTSAEIFLLDEDFVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARGGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1490, "header": "tr|A0AAA9SBT5-1|F1N322_BOVIN Computationally mapped isoform of Nischarin OS=Bos taurus OX=9913 GN=NISCH PE=4 SV=1 CANONICAL=F1N322-1" }, "locus": { "chromosome": "22", "start_pos": 48431329, "end_pos": 48371219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108120.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108120.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082852.1" } ] } }, { "isoform_ac": "A0AAA9T2Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q1/entry", "sequence": { "sequence": "MPARSSARAMEEAKRGPLLLSKGQVYIIQITDGSHEWTVKHRYSDFHDLHEKLVAEKKIDRSLLPPKKIIGKNSRSLVEKREKDLEIYLQTLLATFPDVAPRVLAQFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDARRIRGLVASKPTLATMSVRFSATSMKEVLVPEASEFDEWEPAGAALEGPVTAVIPTWQALTALDLSHNSISEIDDSVKLIPKIEFLDLSHNGVLVMNNLQHLYNLVHVDLSYNKLSSLEGAHTKLGNIKTLNLAGNLLRHLSGLHKLYSLVNLDLSDNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKVSEDSRLSAAPCVRPSSSPPSAAPTSASLPQPILSNQGIMFVQEDALASSLSSTDSLTPEDRSIVGGCSDSLESIPAGQAPSDDLRDVPGAVGGVSPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEDDEEEEDVAENRYFEMGPPDTEEEEEGGPGEEEEEEEEEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAAHLHEFHADLRACFAPQHMAMLCSPVLYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAPGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKTPATGGGPQSPLVDGQPAESRASSDQNLQEAPAETTAPALVEAPALTPGEASAPSPAKTPAPVEASVPALVPVEVPEEAEASAEIPVEALAQAEAPAQYPSEPLIRSMSEDNQIPSHLPACPSLRHIASLRGRAVVEFFHSSIAEVENEELRHLLWSSVVFYQMPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQVVNVGLFDQYFRLTGSCPAQVVTCLTRDSYLTHCFLQHLMAVLSLLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEVGDLTFTVAQKMAAPEKAPALSILLCVQAFQVGSPQPGRCRGLLRPKTLLLTSAEIFLLDEDFVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARGGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1500, "header": "tr|A0AAA9T2Q1-1|F1N322_BOVIN Computationally mapped isoform of Nischarin OS=Bos taurus OX=9913 GN=NISCH PE=4 SV=1 CANONICAL=F1N322-1" }, "locus": { "chromosome": "22", "start_pos": 48430417, "end_pos": 48371219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112048.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112048.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090725.1" } ] } }, { "isoform_ac": "F1N322-1", "url": "https://www.uniprot.org/uniprotkb/F1N322/entry", "sequence": { "sequence": "MAAAARSFGPEREAEPVKTARVVGSELVDTYTVYIIQITDGSHEWTVKHRYSDFHDLHEKLVAEKKIDRSLLPPKKIIGKNSRSLVEKREKDLEIYLQTLLATFPDVAPRVLAQFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDARRIRGLVASKPTLATMSVRFSATSMKEVLVPEASEFDEWEPAGAALEGPVTAVIPTWQALTALDLSHNSISEIDDSVKLIPKIEFLDLSHNGVLVMNNLQHLYNLVHVDLSYNKLSSLEGAHTKLGNIKTLNLAGNLLRHLSGLHKLYSLVNLDLSDNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKVSEDSRLSAAPCVRPSSSPPSAAPTSASLPQPILSNQGIMFVQEDALASSLSSTDSLTPEDRSIVGGCSDSLESIPAGQAPSDDLRDVPGAVGGVSPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEDDEEEEDVAENRYFEMGPPDTEEEEEGGPGEEEEEEEEEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAAHLHEFHADLRACFAPQHMAMLCSPVLYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAPGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKTPATGGGPQSPLVDGQPAESRASSDQNLQEAPAETTAPALVEAPALTPGEASAPSPAKTPAPVEASVPALVPVEVPEEAEASAEIPVEALAQAEAPAQYPSEPLIRSMSEDNQIPSHLPACPSLRHIASLRGRAVVEFFHSSIAEVENEELRHLLWSSVVFYQMPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQVVNVGLFDQYFRLTGSCPAQVVTCLTRDSYLTHCFLQHLMAVLSLLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEVGDLTFTVAQKMAAPEKAPALSILLCVQAFQVGSPQPGRCRGLLRPKTLLLTSAEIFLLDEDFVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARGGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1508, "header": "tr|F1N322-1|F1N322_BOVIN Isoform 1 of Nischarin OS=Bos taurus OX=9913 GN=NISCH PE=4 SV=3 CANONICAL=F1N322-1" }, "locus": { "chromosome": "22", "start_pos": 48432678, "end_pos": 48371219, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019661.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019661.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019661.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019661.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336473", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336473", "resource": "KEGG Pathway" }, { "id": "R-BTA-9696264", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "resource": "Reactome", "description": "RND3 GTPase cycle" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RKR1-1", "protein_name": "Nischarin", "gene_name": "NISCH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAARSFGPEPEAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKLVAEKKIDKSLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLATFPDVAPRVLAHFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQHLPFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATMSVCFSATSMKEVLVPEASEFDEWEPAGAALEGPVTAIIPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLNLAGNLLGSLHGLHKLYSLVNLDLSNNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELDTVEVLKAIQKAKEVKSKLSNTEKKVSEDSRLSAATCIRPSGSPPTVAPTSASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEDRPIARGCSDSLESIPAGQALCDEIRDVPGAVGGASPEHSEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGRGEQGEEEEEEEEEDVAENRYFEMGPPDVEEEEEGGPGEEEEEEEEEEEEEGEEGEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDATNLHEFHADLRSCFAPQHMAMLCSPVLYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRIYNQLRASLQDLKTVVIAKTPATGGRPQSPLADGQPTEGRASDDQHLQEALEEVPVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQYPSERLIQSMSEENQIPSHLPACPSLQHIASLQGSAVVEFFHNSIAEVENEELRHLLWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQTVNVGLFDQYFRLTGSSPAQVVTCLTRDSYLTHCFLQHVMAVLSLLERTPSPEPVDKDFYSEFGNKTTGKVENYELIHSSRVKFTYPSEEEIGDLTFTVAQKMADPEKAPGLSILLYVQAFQVGMPLPGRCRGLLRPKTLLLTSAEIFLLDEDFVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEEPGGPARAGQGREVQWQVFIPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1520 }, "evidence": [ { "id": "F1N322", "url": "https://omabrowser.org/oma/group/F1N322/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A6X1-1", "protein_name": "Nischarin", "gene_name": "NISCH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAAAAAGEDGEEPLRSARVLGSELVETYTVYIIQVSVGNHQWTVKHRYSDFHDLHEKLVSEKKIDKNLLPPKKIIGKNSKSLVEKRQKELEVYLQTLLVKFSVTAPKVLSHFLHFHFYEINGITAALAEELFHKGEQLLMAGEVFTIRPLQLYAVTQQLLQGKPTCANGDAKTDLGHILDFTCRLKYLKVTGTGGPFGTSNIQEHHLPFDLSIFKSLHQIEINHCGGKLIKGLTSSKHTLATMSVRFSATSMKEILVPEASEFDQWEPEGASASCPVTAVIPTWRNLTTLDMSHNNISQIDDSVKLIPKIEFLDLSHNGVSLVENLQHLYNLVHLDLSYNKLTSLEGVHTKLGNIKTLNLAGNQLESLYGLNKLYSLVNLDLSSNRIEQIDEVKNIGSLPCLEKVVLSSNPLSIIPDYRTKVLAQFGDRASEVCLDNIVTTEKELDTVEVLKAIQKSKEVKYKLSNSDKKISEDFRLTAASSKSNCSSLTVRPSSPSLPRPVSSSQEIVCEETVLASSSFQFNASTPTDHTVPQRCSEIPDSRCKNQAPVSLLEYGRGDNTCLDHPEEERCTVPDPCNTVILPFNCMSYTATNQDFTQHLSALIAQTVQRTTPSFIENKGSLPAGSRTTDKEDGYFEMGLHEGDQTFEFSTSQTQSSDNVAVKSINVVKILWSFSIHIYKEVRQFASCLVLTDDLLAVFEIPPQELRGSCQHIPSALKLILCFPYADLTEFGFLMPEICLMLKLKNSDNCLFVVSDSQNLQDFYSCLHTCHSRHCTSVLPSSTTYCGSANLQEFLSQLMELNCISSEDVEIKGCFPTYLVYGNKTNAQKTLHQPDSAGSNKAWSKDDLRSTLYSSMYKSSDQCPCVFHPCWLFLTTQHLYIIKVDFSVLPNKWIGTEDLRSVLKLNSIPLASVVLHPTHGSIQQKGSFLDGHVLELLIGYRFVTAVFVLPHEKFHFLRVYSLLRTLLKNVKTIIVFKASNKSDAARNHVLESNRHGQSASFYKPHLTLSSLYPSEFLIQKITEDNQIPVHLHASVSLQYVAGLKGNALVEFFHGNIAEVENEELRHLMWSSVLFYKTPSVEVMACVLLSTKAIYFLLDDTFNHADEQQSDFWNQENSDCENNSFHLSCCLVLKLNDLQSVNVGLFDQYFRITGQSADHIVTCLTRDSYNTHAFMQQLMAVLSLLARTPSPEPIDKDFYSEFGSKNTGKMENYELIHSSRVKFIYPNEEEIGDLAFLVAEKMDDLTHLQSLHILLYVLAFQVNPVEGSAQNTSPLQPKTLILTSSDLFLFDEDYICYPLPEFAKEPPKRDKYRLADGRRIRDLDRVLMGYQTYPQALTFVFDDVQNQNLMQNLALNHFGDADSAPKGNAKQEGNRSREIQWYIFIPSAESRERLISLLARQWEILCGRELPLELTG", "length": 1416 }, "evidence": [ { "id": "F1N322", "url": "https://omabrowser.org/oma/group/F1N322/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q4G017-1", "protein_name": "Nischarin", "gene_name": "Nisch", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAATLSFGPEREAEPAKEARVVGSELVDTYTVYVIQVTDGNHEWTIKHRYSDFHDLHEKLVAERKIDKTLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLKTFPDVAPRVLAHFLHFHLYEINGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIREQLLPFDLSIFKSLHQVEMSHCDAKHVRGLVTSKPTLATMSVRFSAASMKEVLVPEASEFDEWEPEGTTLGGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEYLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVKTLNLAGNFLERLSGLHKLYSLVNLDLRDNRIEQLDEVKSIGNLPCLEHVALLNNPLSIIPDYRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSKLSSTEKKVGEDFRLPTAPCIRPSSSPPTAVPTSASLPQPILSNQGIMFVQEEALASSLSSTDSLPPDDRPIAQACSNSMGSLPTGQVAAEDLRDLPGAVGGVSPDHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEAHGEQGEEEEEEEEEDVAESRYFEMGPPDAEEEEGSGQGEEDEEDEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFYKVAGGSQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTSQHLNVIKADFNPMPSRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLKDLKTVVIAKNPSARPRTQGPLAGGQPAKSRVSAEQRLQETPAEAPAPAPAAAESAAEAPAAAEASAPAGAPAPAGAPAPAGAPAGAQAPAPAQAEVPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAIIDLFHSSIAEVENEELRHLLWSSVVFYQTPGLEVTACVLLSTKAVYFILHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDSYLTHCFLQHLMLVLSSLERTPSPEPIDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSEEEVGDLTYVVAQKMADPAKNPALSILLYIQAFQVITPQLGRGRGPLRPKTLLLTSAEIFLLDEDYIHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYNPYPQALTLVFDDTQGHDLMGSVTLDHFGEMPGGPGRAGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1502 }, "evidence": [ { "id": "F1N322", "url": "https://omabrowser.org/oma/group/F1N322/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80TM9-1", "protein_name": "Nischarin", "gene_name": "Nisch", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAATLSFGPEREAEPAKEARVVGSELVDTYTVYVIQVTDGNHEWTIKHRYSDFHDLHEKLVAERKIDKSLLPPKKIIGKNSRSLVEKRERDLEVYLQTLLTTFPDVAPRVLAHFLHFHLYEVNGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIKEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVTSKPTLATMSVRFSATSMKEVLAPEASEFDEWEPEGTATLGGPVTAIIPTWQALTTLDLSHNSICEIDESVKLIPKIEYLDLSHNGLRVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVKTLNLAGNFLESLSGLHKLYSLVNVDLRDNRIEQLDEVKSIGSLPCLERLTLLNNPLSIIPDYRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSKLSNTEKKAGEDFRLPPAPCIRPGGSPPAAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLPPEDHRPIARACSDSLESIPAGQVASDDLRDVPGAVGGVSPDHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEAHGEQGEEEEEEEEEEDVAENRYFEMGPPDAEEEEGSGQGEEDEEDEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTTLQEFLRQLLTFYKVAGGSQERSQGCFPVYLVYSDKRMVQTPAGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTSQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVISKNPSAKPRNQPAKSRASAEQRLQETPADAPAPAAVPPTASAPAPAEALAPDLAPVQAPGEDRGLTSAEAPAAAEAPAAAEAPAAAEAPAAAEAPAAAEAPAAAEAPAPAEAPAAAEAPAAAEAPAAAEAPAAAEAPASAEAPAPNQAPAPARGPAPARGPAPAGGPAPAEALAQAEVPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAIIDLFHNSIAEVENEELRHLLWSSVVFYQTPGLEVTACVLLSSKAVYFILHDGLRRYFSEPLQDFWHQKNTDYNNSPFHVSQCFVLKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDSYLTHCFLQHLMLVLSSLERTPSPEPVDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSEEEVGDLTYIVAQKMADPAKNPALSILLYIQAFQVVTPHLGRGRGPLRPKTLLLTSAEIFLLDEDYIHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYYPYPQALTLVFDDTQGHDLMGSVTLDHFGEMPGGPGRVGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1593 }, "evidence": [ { "id": "F1N322", "url": "https://omabrowser.org/oma/group/F1N322/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2I1-1", "protein_name": "Nischarin", "gene_name": "NISCH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKLVAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSVSEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPPDVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTGGSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEASTSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSAIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTRDSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPSEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEIFLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHDLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVELTG", "length": 1504 }, "evidence": [ { "id": "F1N322", "url": "https://omabrowser.org/oma/group/F1N322/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" }, { "name": "Rac protein signal transduction", "id": "GO:0016601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016601", "evidence": [ { "database": "UniProtKB", "id": "F1N322", "url": "https://www.uniprot.org/uniprotkb/F1N322" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1219, "end_pos": 1221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1302, "end_pos": 1304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N322" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 128, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1219, "end_pos": 1221 }, { "start_pos": 1302, "end_pos": 1304 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7C1-1", "uniprot_ac": "F1N7C1", "uniprot_id": "F1N7C1_BOVIN", "mass": { "chemical_mass": 114106.0, "monoisotopic_mass": 114106.0 }, "refseq": { "ac": "XP_010804331", "name": "probable E3 ubiquitin-protein ligase HERC6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804331" }, "gene_names": [ { "name": "HERC6", "type": "recommended", "evidence": [ { "id": "F1N7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ] }, { "name": "HERC6", "type": "synonym", "evidence": [ { "id": "XP_010804331", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804331" } ] } ], "protein_names": [ { "name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 6", "type": "synonym", "evidence": [ { "id": "F1N7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7C1/entry#names_and_taxonomy" } ] }, { "name": "probable E3 ubiquitin-protein ligase HERC6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010804331", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804331" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HERC6", "url": "https://www.uniprot.org/uniprotkb/F1N7C1", "locus": { "chromosome": "6", "start_pos": 36309709, "end_pos": 36366769, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020536", "url": "https://www.ensembl.org/id/ENSBTAG00000020536" } ] } } ], "crossref": [ { "id": "F1N7C1", "url": "https://alphafold.ebi.ac.uk/entry/F1N7C1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020536", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020536", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527520", "url": "https://www.ncbi.nlm.nih.gov/gene/527520", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NFVTTYQ", "url": "https://omabrowser.org/oma/group/NFVTTYQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N7C1", "url": "https://www.orthodb.org/?gene=F1N7C1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45622", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45622", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45622:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45622:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010804331", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804331", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S348", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S348", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S348-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S348-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7C1-1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYFCWRAGGRRPLRERQVCAGGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRGPGCASRSPHPGAESSDISCLVSAKDLADVQVKHIFAGTYANFVTTSQKDTSSTSVPRKTLPEISRINQSLTEKWMAVAKRSIEDEVAKSEIRVIFSSPACLTASFLKKREPGEMISIDVDLEMARDTFKKLTEKEWISSMITACLKDNLLGALPCHSSHQEALSVFLLLPECPVMLDSRNYITLVVPFAEAIRKMTNQSSKVLKRCWTSLQESSLSSLVQMLKTAIISQMVCWTETVQSNHNVKTLLEVMKDVYKVNKTNCRLSEDTFHINEVSFLLNFYEDRIRVINREKNLIPAENFSPIIFSDFPFVFNLMSKIKLLQADSQIRVLKSEVNNYMDFRGIILQRRDESPLFTLSVRRSHLVEDALCQLSQAEDTDLQKILVVEFIKEIRSGGEGVKSEFFHCIFESMTKEEYGMFMYPEEDSYMWFPVKPKFEKKMYFLFGMLCGLSLYNFNVVYLPFPLALFKKLLDQEPSLEDLKELSPSFGKCLQEVLNDDANDIKEEFGLRFSIHWDQNDVDLIPNGISVFVDQSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDWEQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLTGNDRLHVKGIQKPGIRFRCPETCSESDFPKSLTCHNILELPEYSTMKKVKEALQRAINSNKGFISATVTG", "length": 1017, "header": "tr|F1N7C1-1|F1N7C1_BOVIN Isoform 1 of HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 OS=Bos taurus OX=9913 GN=HERC6 PE=4 SV=3 CANONICAL=F1N7C1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S348-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S348/entry", "sequence": { "sequence": "MYFCWRAGGRRPLRERQVCAGGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRGPGCASRSPHPGAESSDISCLVSAKDLADVQVKHIFAGTYANFVTTSQKDTSSTSVPRKTLPEISRINQSLTEKWMAVAKRSIEDEVAKSEIRVIFSSPACLTASFLKKREPGEMISIDVDLEMARDTFKKLTEKEWISSMITACLKDNLLGALPCHSSHQEALSVFLLLPECPVMLDSRNYITLVVPFAEAIRKMTNQSSKVLKRCWTSLQESSLSSLVQMLKTAIISQMVCWTETVQSNHNVKTLLEVMKDVYKIPAENFSPIIFSDFPFVFNLMSKIKLLQADSQIRVLKSEVNNYMDFRGIILQRRDESPLFTLSVRRSHLVEDALCQLSQAEDTDLQKILVVEFIKEIRSGGEGVKSEFFHCIFESMTKEEYGMFMYPEEDSYMWFPVKPKFEKKMYFLFGMLCGLSLYNFNVVYLPFPLALFKKLLDQEPSLEDLKELSPSFGKCLQEVLNDDANDIKEEFGLRFSIHWDQNDVDLIPNGISVFVDQSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDWEQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLTGNDRLHVKGIQKPGIRFRCPETCSESDFPKSLTCHNILELPEYSTMKKVKEALQRAINSNKGFISATVTG", "length": 979, "header": "tr|A0AAA9S348-1|F1N7C1_BOVIN Computationally mapped isoform of HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 OS=Bos taurus OX=9913 GN=HERC6 PE=4 SV=1 CANONICAL=F1N7C1-1" }, "locus": { "chromosome": "6", "start_pos": 36366649, "end_pos": 36309918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105784.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105784.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079528.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079528.1" } ] } }, { "isoform_ac": "F1N7C1-1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1/entry", "sequence": { "sequence": "MYFCWRAGGRRPLRERQVCAGGNTLLQAASGEHHSLLLLSDGTVQSCGDNSRGQLGRKGTPRGEQPERIPALETLNVALVSCGKEHSLAVCHKGRVFAWGAASEGQLGIGEFKETTFIPKKIKTLAGIKIIQVACGHYHSVALSEDGQVFSWGTNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGHHSFALSLSGTSFGWGSNSAGQLALSGNNAPVQRYKPVSIGALKTLGVVSISCGYKHTAVLTQDGKVFTFGDNSYGQLGHDPTAEKRGPQLVERIEGLVSQIDCGSDHTLAYIYTTGQVVSFGRGPGCASRSPHPGAESSDISCLVSAKDLADVQVKHIFAGTYANFVTTSQKDTSSTSVPRKTLPEISRINQSLTEKWMAVAKRSIEDEVAKSEIRVIFSSPACLTASFLKKREPGEMISIDVDLEMARDTFKKLTEKEWISSMITACLKDNLLGALPCHSSHQEALSVFLLLPECPVMLDSRNYITLVVPFAEAIRKMTNQSSKVLKRCWTSLQESSLSSLVQMLKTAIISQMVCWTETVQSNHNVKTLLEVMKDVYKVNKTNCRLSEDTFHINEVSFLLNFYEDRIRVINREKNLIPAENFSPIIFSDFPFVFNLMSKIKLLQADSQIRVLKSEVNNYMDFRGIILQRRDESPLFTLSVRRSHLVEDALCQLSQAEDTDLQKILVVEFIKEIRSGGEGVKSEFFHCIFESMTKEEYGMFMYPEEDSYMWFPVKPKFEKKMYFLFGMLCGLSLYNFNVVYLPFPLALFKKLLDQEPSLEDLKELSPSFGKCLQEVLNDDANDIKEEFGLRFSIHWDQNDVDLIPNGISVFVDQSNKKDYVSKCVDYVLNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDWEQFEKNSIYEQGYHESHPTILMFWKAFHSLTLDEKRKFLFFLTGNDRLHVKGIQKPGIRFRCPETCSESDFPKSLTCHNILELPEYSTMKKVKEALQRAINSNKGFISATVTG", "length": 1017, "header": "tr|F1N7C1-1|F1N7C1_BOVIN Isoform 1 of HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 OS=Bos taurus OX=9913 GN=HERC6 PE=4 SV=3 CANONICAL=F1N7C1-1" }, "locus": { "chromosome": "6", "start_pos": 36366649, "end_pos": 36309918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027362.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027362.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027362.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027362.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AMT7-1", "protein_name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 6", "gene_name": "HERC6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYFCWSGDRPRSQNPGPAGPGGDALLQAASGERHSLLLLSNGAVQSCGDNSHGQLGRKGVQRGERPERIPALKTLPVRLVSCGKEHSLAVCHRGRVFAWGAGSEGQLGTGDFKEVNFIPKKITLTDIKIIQVSCGHYHSLALSEDGQVFSWGKNSDGQLGLGKEVPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLPGTSFGWGSNRAGQLALSGNNVPAQAYKPRSVGALKNLGVIYISCGYEHTAVLTQDGKVFTFGDNSYGQLGHSPTAEKRGPRLVERIEGLVSQIDCGSYHTLAYVYTTGQVVSFGRGPSCPGSSLHPEALAEDFDISCLISADDLADSQVKHIFAGTYADFVTTCQKDPSSNGVPRKTLPEISRIHQSLTEEWMAVAKGSAQFEAAESKIKAVFSSPACLTASFLKKRECGETNSIYVDLQMARDTFEKLTKKDWISFLITTSLKDNLLPALPHRSPHQEALSVFLLLPECPVMHDAKNWMALVVPFAEAVHKMTSQSLQVLKQCWESLQESSFNALVQMLKTAIVSQLYYWTETIQSHNNLKALLKMMKEVYKVNKANCRLPENTFYIDELHFLLNFYAERSRMIFRNKSQISAENFDFIIFSDFPFVFNLPSKIKLLQADSHLKMMELEGKAHMDFNQVILQRKDEFPPSPIFTLKVRRSHLVEDTLRQLSQADATDLRKVLVVEFIKEICSVGEGVKSEFFHCIFEEMIKKEYGLFIYPEDGSCMWFPVNPTRGKKMYFLFGILCGLSLYNLNVVNLPFPLALFKKLLDQKPSLEDLKELSPLLGKSLQEVLNDEADDIKEELGLCFSIYWDKEAVDLIPNGSSVSVDQINKKDYISKYVNYIFNASVMGVYEEFQRGFHKVCDKEILKLFHPEELMTAIVGHTDYDWQQFEKNSAYDQGYHVSHPTIVMFWKAFHKLTLDEKKKFLFFLTGNDRLHVRGVQKMGILFRCPETLSERDNPRPLTCHNILDLPKYSTMERMEEALQVAINNHKGFTSPRVTG", "length": 1021 }, "evidence": [ { "id": "F1N7C1", "url": "https://omabrowser.org/oma/group/F1N7C1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1LPM8-1", "protein_name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 6", "gene_name": "Herc6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYFTWAPGRRQPRRLEAGTGLKLLKAASGERHSLLLFSNHRVYSCGDNSRGQLGQKSPQSTKRPEPIQALSTVHIDLVSCGKEHSVAVCHQGRVFTWGAGSEGQLGIGESKEISFMPTKINSLAGIKIIQVSCGHYHSLALSEDGQVFSWGSNRQGQLGLGNNLCSQASPQKVKSLEGIPLAQVAAGGTHSFALSLMGTSFGWGNNRSGQLALSGNSAKEQIYKPHSIGALKTLNVVYISCGYEHTSVLTEDGQVFTFGGSSSEQLQHSPRSGRGGPQLIEGIGGHVSQIECGSYHTIAYVYTTGQVVSLGRGPSCTSNATHQEAACSDVTCLLSAKDLVDIEVKDIFAGAHANFVTTCRHTRSTSVSMKILPEIIRITQPLVKKWRAAKKGKVHEDAKREISLIFSSPACLTASFLKKRDAGENNFINVDLKLARDVFKMLTAEKWISSLITTCLEETLLRGLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFASAIHKMRSKSLTFLRNWWASLEVSSLNSLVQMLKKTIVSQLHNEVPMMKDTSNLKVSLEMMKEVQKILEKTNSHLHNEVPKMEDTSNLKVLLEVMKEVHEANCQLPENAFIMNDIFNFNTEEGIMAKQQMFFIKYYSMVFNDFPFILDLPSKIILMKHDSSVKLSDEVKVAASPEKMGCPFFILKVRRSHLVEDTLRQLRQAEDFDLRKTLSVGFINEIRPEGGGVSSEFFHCIFEEMTDPKYEMFMYPENGSNMWFPVNPKFEKSRYFLFGILCGLSLNNLNVINLSFPLALYKKLLEQKPSLEDLKDLSLLLGRNLQEVLNCEAGVIEELHMYFSIYWDQRDVDLIPDGISVPVNETNKRDYVSKCVDYIFNISIKTIYDEFHRGFYKVCNRDSIRHFQPEELMAAIIGNPTCDWKQFENNSKYENGYSKSHPTILLFWKAFHELTLDEKKKFLLFLTGCDRLHVKGLQNEGIRFRCPEVFSERDNPRSLTCHSILDLPKYSTMRRMKEALQVAINNNKGFISPE", "length": 1027 }, "evidence": [ { "id": "F1N7C1", "url": "https://omabrowser.org/oma/group/F1N7C1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F2Z461-1", "protein_name": "E3 ISG15--protein ligase Herc6", "gene_name": "Herc6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYFSWAAGSRKPRRLKAGTSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLIEGIGGRVSQIECASYHTIAYVYTTGQVVSLGRGPSHTSNPTHQEAPAENSDITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVSHTRSTGVSMKILPEIIRINQSLVKKWRAANKRKDREGAKREISLIFSSSACLTASFLKKRDAGENNLIDVDLKLARDVFKKLTTEKWISSLITTCLEEYLLRDLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFAKAIHKMGPQSLAFLRTCWASLEVSSLNILVQMLKKAIISQIQYGVATEQYITNIKVLLEVIKEVHKANCQLPESAFIINELSGIFNFDAEAGRMFIRHNDLDCTESSDMVVFSDFLFVFDLPSKIKLMKCDSFVKLMSEVMAFPEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMFIYPEKGSSMWFPVNPKFEKSSYFLFGILCGLSLHNLKVINLPFPLALYKKLLNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEELHMYFSIYWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKGLQNEGIVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGFVSQE", "length": 1003 }, "evidence": [ { "id": "F1N7C1", "url": "https://omabrowser.org/oma/group/F1N7C1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IVU3-1", "protein_name": "Probable E3 ubiquitin-protein ligase HERC6", "gene_name": "HERC6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLTQS", "length": 1022 }, "evidence": [ { "id": "F1N7C1", "url": "https://omabrowser.org/oma/group/F1N7C1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N7C1", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" }, { "start_pos": 861, "end_pos": 863, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7C1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1017, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7C1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7C1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7C1" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 689, "end_pos": 1013, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 382, "end_pos": 384 }, { "start_pos": 512, "end_pos": 514 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 613, "end_pos": 615 }, { "start_pos": 861, "end_pos": 863 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4V1-1", "uniprot_ac": "F1N4V1", "uniprot_id": "F1N4V1_BOVIN", "mass": { "chemical_mass": 75138.0, "monoisotopic_mass": 75138.0 }, "refseq": {}, "gene_names": [ { "name": "C3H1orf226", "type": "recommended", "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1" } ] }, { "name": "NOS1AP", "type": "recommended", "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1" } ] }, { "name": "C3H1orf226", "type": "synonym", "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1" } ] } ], "protein_names": [ { "name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "type": "recommended", "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1/entry#names_and_taxonomy" } ] }, { "name": "C-terminal PDZ ligand of neuronal nitric oxide synthase protein", "type": "synonym", "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1/entry#names_and_taxonomy" } ] }, { "name": "Nitric oxide synthase 1 adaptor protein", "type": "synonym", "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8F3#function" }, { "database": "UniProtKB", "id": "ARBA00054402", "url": "https://www.uniprot.org/uniprotkb/ARBA00054402#function" }, { "database": "UniProtKB", "id": "F1N4V1", "url": "https://www.uniprot.org/uniprotkb/F1N4V1#function" }, { "database": "UniProtKB", "id": "A0AAA9T2C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C6#function" }, { "database": "UniProtKB", "id": "A0AAA9U0Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4V1", "url": "https://www.uniprot.org/uniprotkb/F1N4V1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOS1AP", "url": "https://www.uniprot.org/uniprotkb/F1N4V1", "locus": { "chromosome": "3", "start_pos": 7108525, "end_pos": 7468587, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010158", "url": "https://www.ensembl.org/id/ENSBTAG00000010158" } ] } } ], "crossref": [ { "id": "F1N4V1", "url": "https://alphafold.ebi.ac.uk/entry/F1N4V1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010158", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010158", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01270", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01270", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11232:SF76", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11232:SF76", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15429", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15429", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U005", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U005", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U005-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U005-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4V1", "url": "https://www.uniprot.org/uniprotkb/F1N4V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4V1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4V1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQPGPAPTSHGGAGVQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 697, "header": "tr|F1N4V1-1|F1N4V1_BOVIN Isoform 1 of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=4 CANONICAL=F1N4V1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8F3/entry", "sequence": { "sequence": "MCMRSAYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 659, "header": "tr|A0AAA9S8F3-1|F1N4V1_BOVIN Computationally mapped isoform of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=1 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7453752, "end_pos": 7110819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079624.1" } ] } }, { "isoform_ac": "A0AAA9T0R0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R0/entry", "sequence": { "sequence": "MVGIMVLASGLEPGRSQQLTVVRSFHWPRKETEYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 657, "header": "tr|A0AAA9T0R0-1|F1N4V1_BOVIN Computationally mapped isoform of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=1 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7291794, "end_pos": 7110819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109193.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109193.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089968.1" } ] } }, { "isoform_ac": "A0AAA9T2C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C6/entry", "sequence": { "sequence": "MQKGREERCEQPRRMYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 663, "header": "tr|A0AAA9T2C6-1|F1N4V1_BOVIN Computationally mapped isoform of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=1 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7391232, "end_pos": 7110819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117880.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117880.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090575.1" } ] } }, { "isoform_ac": "A0AAA9TZQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZQ4/entry", "sequence": { "sequence": "VLLLVAQTGDDTPHVVGHYIKRVSLSFVSHLLSEPLSRTVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 307, "header": "tr|A0AAA9TZQ4-1|F1N4V1_BOVIN Computationally mapped isoform of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=1 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7115573, "end_pos": 7110819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107102.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107102.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102773.1" } ] } }, { "isoform_ac": "A0AAA9U005-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U005/entry", "sequence": { "sequence": "MRPRESTQMHFLQWLVCRERLVLYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 647, "header": "tr|A0AAA9U005-1|F1N4V1_BOVIN Computationally mapped isoform of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=1 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7259890, "end_pos": 7110819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135731.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135731.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103176.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103176.1" } ] } }, { "isoform_ac": "A0AAA9U0Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z7/entry", "sequence": { "sequence": "MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKESCPAAFLWPGDPVRG", "length": 641, "header": "tr|A0AAA9U0Z7-1|F1N4V1_BOVIN Computationally mapped isoform of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=1 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7467724, "end_pos": 7109529, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129837.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129837.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103665.1" } ] } }, { "isoform_ac": "F1N4V1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4V1/entry", "sequence": { "sequence": "MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSSSSGDPGRQLTGAERTSTATAEETDIDAVEVPLPGNDALEFSRGVTDLDAVGKEGGSHTDPKVPPHPQEPMLTASPRMLLPSSSSKPPDLGAGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQPGPAPTSHGGAGVQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLHSPPLGAGLADFAHPAGSPLVDHSMFENLNTALTPKLQSSRSFPHLSRPTAPSAAAQGSVEPGGPGLWVGSSQHLKSLGKAVGAKVNDFLRRKEPSSLGSVGTTEVNKTAGAQLAGGADGDDGRSALQEAFPRLDPPPPATRKRTPRALKTTQDMLISSQPVLSSLEYGTELSSGQPQVSSSAQPSPADASQPEATTEVVDRDDALPNGEVSVSVPDLIHKDGQDDPKLKVTECRRASSPGLMERNGLKLSLSPISLAESPEDGSPPPRARTSSVDNEGPHPDLLSFE", "length": 697, "header": "tr|F1N4V1-1|F1N4V1_BOVIN Isoform 1 of Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Bos taurus OX=9913 GN=NOS1AP PE=4 SV=4 CANONICAL=F1N4V1-1" }, "locus": { "chromosome": "3", "start_pos": 7467724, "end_pos": 7110819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048340.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048340.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045400.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045400.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4V1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 697, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4V1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4V1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4V1" }, { "id": "PS01179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PID", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 165, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 186, "end_pos": 188 }, { "start_pos": 516, "end_pos": 518 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Z0-1", "uniprot_ac": "F1N6Z0", "uniprot_id": "F1N6Z0_BOVIN", "mass": { "chemical_mass": 61624.0, "monoisotopic_mass": 61624.0 }, "refseq": {}, "gene_names": [ { "name": "PSMD5", "type": "recommended", "evidence": [ { "id": "F1N6Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 5", "type": "recommended", "evidence": [ { "id": "F1N6Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E4#function" }, { "database": "UniProtKB", "id": "ARBA00055861", "url": "https://www.uniprot.org/uniprotkb/ARBA00055861#function" }, { "database": "UniProtKB", "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD5", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0", "locus": { "chromosome": "8", "start_pos": 110196042, "end_pos": 110217313, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016952", "url": "https://www.ensembl.org/id/ENSBTAG00000016952" } ] } } ], "crossref": [ { "id": "F1N6Z0", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Z0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016952", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016952", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WGQEYIS", "url": "https://omabrowser.org/oma/group/WGQEYIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6Z0", "url": "https://www.orthodb.org/?gene=F1N6Z0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13554", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13554", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13554:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13554:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10508", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10508", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Z0-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLVRPGRFGLSQNSREGRLRPADLARLEEAPREPGAGRADWRTRAGGGIMAAQALALLREVSRLEAPLEELRALQSLLQSVPLSELREQAAELRLGPLFSLLNENHREQTTLCVSILERLLQALEPVHVARNLRVDLQRGLTHPNDSVKILTLSQVGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKTAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDIVRYRVYELIVEISSVSPESLNCCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLACTHHGRQYLAQEGVIDQISNIIVGADADPFSSFYLPGFVKFFGNLAIMDSPQQICERYPIFMEKVFEMTESQDPTMIGVAVDTIGILGSNVEGKQVLQKTGTRFERLLMKIGYQAKNASTELKIRCLDALSSLFYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVMDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPISTTAVEGAE", "length": 554, "header": "tr|F1N6Z0-1|F1N6Z0_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 5 OS=Bos taurus OX=9913 GN=PSMD5 PE=3 SV=2 CANONICAL=F1N6Z0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E4/entry", "sequence": { "sequence": "MLLVRPGRFGLSQNSREGRLRPADLARLEEAPREPGAGRADWRTRAGGGIMAAQALALLREVSRLEAPLEELRALQSLLQSVPLSELREQAAELRLGPLFSLLNENHREQTTLCVSILERLLQALEPVHVARNLRVDLQRGLTHPNDSVKILTLSQVGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKTLIVEISSVSPESLNCCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLACTHHGRQYLAQEGVIDQISNIIVGADADPFSSFYLPGFVKFFGNLAIMDSPQQICERYPIFMEKVFEMTESQDPTMIGVAVDTIGILGSNVEGKQVLQKTGTRFERLLMKIGYQAKNASTELKIRCLDALSSLFYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVMDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPISTTAVEGAE", "length": 511, "header": "tr|A0AAA9S9E4-1|F1N6Z0_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 5 OS=Bos taurus OX=9913 GN=PSMD5 PE=3 SV=1 CANONICAL=F1N6Z0-1" }, "locus": { "chromosome": "8", "start_pos": 110217114, "end_pos": 110196381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099284.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099284.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081910.1" } ] } }, { "isoform_ac": "F1N6Z0-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0/entry", "sequence": { "sequence": "MLLVRPGRFGLSQNSREGRLRPADLARLEEAPREPGAGRADWRTRAGGGIMAAQALALLREVSRLEAPLEELRALQSLLQSVPLSELREQAAELRLGPLFSLLNENHREQTTLCVSILERLLQALEPVHVARNLRVDLQRGLTHPNDSVKILTLSQVGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKTAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDIVRYRVYELIVEISSVSPESLNCCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLACTHHGRQYLAQEGVIDQISNIIVGADADPFSSFYLPGFVKFFGNLAIMDSPQQICERYPIFMEKVFEMTESQDPTMIGVAVDTIGILGSNVEGKQVLQKTGTRFERLLMKIGYQAKNASTELKIRCLDALSSLFYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVMDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPISTTAVEGAE", "length": 554, "header": "tr|F1N6Z0-1|F1N6Z0_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 5 OS=Bos taurus OX=9913 GN=PSMD5 PE=3 SV=2 CANONICAL=F1N6Z0-1" }, "locus": { "chromosome": "8", "start_pos": 110217114, "end_pos": 110196381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022548.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022548.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022548.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022548.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UT36-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "PSMD5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAQVLALLREVSRLEAPLEELRALQSVLQSVPLSELREHAAELHLGPLFSLLNENHREQTTLCVSILERLLQALEPVHVARNLKVDLQRGLTHTNDSVKILTLSQVGRIVDNSDAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDIVRYRVYELIVEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAIMDSPQQICERYPVFVEKVFEMTESQDPTMIGVAVDTIGILGSNVEGKQVLQKTGTRFERLLMKIGYQAKNASTELKIRCLDAVSSLFYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVMDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPISTTAVEGAE", "length": 504 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LA61-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "Psmd5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAQAVTLLREVARLEAPLEELRALQSVVHAVPLHELREQAAELRLGPLFSLLNENNREQTALCVSILERLLQAVGPVHVARNLRVDLQRGLTHPDDSVKTLTLSQIGRIVENSEAVTEILNNTELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKNVMKTNDIVRYRVYELIIEISSVSLESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSGFYLPGFVKFFGNLAVMDSPQQICERYPVFLEKVFEMADSQDPTMIGVAVDTVGILGSSVEGKQVLQKTGTRFEHLLTRIGYQAKNASTELKTRCLDAVSSLLYLSPEQQTDDFLRMAESWFASLSQDSLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEFVMDRSVEHDKASKDAKYELVKALANSKTVAEIFGNSNYLRLRTYLSEGPYYVKPVATTAVEGAD", "length": 504 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1AGU4-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "PSMD5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEAVVELLERAARREAPLEELRALRLAVQAVPPAALRARLSDEHLAALFTLLSSSEREQLSACVAVLERLLQALDPLYVIQNLREELRKGLFHPDDSVKILSISQVGRIVENSDAVREILNSPELLRQIINCIGGEKIAVAKEAIKSLSRIAQTQDGLEALFVSSLLSDLKNVMGTNDVVRYRVYELIVEISSVSADSLNYCANSGLISDLIGELTGDDVLVRATCIEMVTSLAHSPHGRQYLAQQGIIDKISNIIIGAESDPFSGFYLPGFIKFFGNLAVVDSPQQICERYPVFMEKVFEMAESHDPTMNGVAVDTLGILGSSVEGKQVLQKARGRFQNLLNKIGHQAKNAPTELRLRCLDAVSSLLYLPPEQQTEDLLRMTESWFSSLSSQPLELFRSISTQPFPDLHCGALRVFTAIANQAWAQKLMLNSPGFVEYIVDRSVEPDKASKDAKYELVKALVNSKTIAEIFGNQYYLRLRAYLNEGPYYVKAVSTTAVEGAE", "length": 504 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QU35-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "psmd5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMAAPIESLLNEICESEDPIEELKSLRTAVLATPVSGLRPAVSGARLEIIFSLLNTNDKEQIEVCVEILSRVLQALEPVQLAQNYRKALQSGLNHPDDSVKVLTLTQIGRVAGHAEGVTQMLNNVEILHDVIQCISVERIAVAKEAIAALSKLSNTKAGLDALFRSDLLNKLKDVMLTSDIIRYRVYELIVEVSTVSPVSLGYCANSGLISQMLEELTGDDVLVRATAIEMVTNLAQSQHGRQYLAQQGIMDKISNMIIAAESDTFSSLYLPGLVKFFGSLAIMDSPQQVCEKYPVFLEVVFSMVMNLDPTLTPVALDTLGVLGGTVEGKQVLQKTGEKFVSVLKRMSKVASDGATELRVRCLEALAQLLTLPVEQQTDDLLLTCESWFNCLSSQPMAMIRNISTQPFPELHCSALRIFTAIGCQPWAQQLMMDTPGFVEWVMDRSVGSGKEAKDCKFELVSALLSSSSVQKIFGAHNYLKLKTYLNEGPYYVTAVSAVTTEGAD", "length": 505 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3V8G2-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "Psmd5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAQAVSLLREVARLEAPLEELRALQSVVQAVPLHELREQAAELRLRPLFSLLNQNNREQTALCVSILERLLQAVEPIHLARNLRLDLQRGLTHPDDSVKTLTLSQIGRIVEDSEAVTEVLSNAELLRQVVCCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKNVMKTNDVVRYRVYELIIDISSVSSESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSGFYLPGFVKFFGNLAVMDSPQQICERYPVFLEKVFAMADSQDPTMIGVAVDTVGILGSSVEGKQVLQKTGTRFERLLTRIGYQAKNASTELKIRCLDAVSSLLYLSPEQQTDDFLGMTESWFSSVSRDSLELFRGISNQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEFVMDRSVEHDKTSKDAKYELVKALANSKTVAEIFGNSNYLRLRTYLSEGPYYVKPVATTAVEGAD", "length": 504 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q16401-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "PSMD5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQALALLREVARLEAPLEELRALHSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLLQAMEPVHVARNLRVDLQRGLIHPDDSVKILTLSQIGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAVMDSPQQICERYPIFVEKVFEMIESQDPTMIGVAVDTVGILGSNVEGKQVLQKTGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISSQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPVSTTAVEGAE", "length": 504 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BJY1-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "Psmd5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAQAVSLLREVARLEAPLEELRALQSVVQAVPLHELREQAAELRLRPLFSLLNQNNREQTALCVSILERLLQAVEPIHLARNLRLDLQRGLTHPDDSVKTLTLSQIGRIVENSEAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKNVMKTNDVVRYRVYELIIDISSVSSESLNYCTTSGLVTQLLKELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSGFYLPGFVKFFGNLAVMDSPQQICERYPVFLEKVFEMADSQDPTMIGVAVDTVGILGSSVEGKQVLQKTGTRFERVLMRVGYQAKNASTELKIRCLDAVSSLLYLSPEQQTDDFLGMTESWFSSMSRDSLELFRGISNQPFPELHCAALKVFTAIADQPWAQRLMFNSPGFVEFVMDRSVEHDKASKDAKYELVKALANSKTVAEIFGNSNYLRLRAYLSEGPYYVKPVATTAVEGAD", "length": 504 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VYG1-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 5", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEMEDNWWVTKLKALESKPQRLDALTAMNSAIAKEAALPRQIIERLLTTDQLYDCANPAADSHVPKDQAVDVTLELLCHCLDQLAMDTADEQLSSLLRRGLTHSNPALRAQVLASLFKKLLRQLTVGQVLTLPNNELIFLILDELKQPDTQSTSLAINILSIVLPQRISNADVQAKLVQLLKQNEIVRCRAYELAVVLAKKSATLLSDVTFILDAALSELDNDDVLLQASVMELLVPLAEQNHGLSYMERRRVLDIISYRVQRVEEHPLDALLVPSIMKFFGKISVYQPLKIIGGYPHMLACLFMQLQSEDESILPTAMDTLANLATTPQGKILLNMHFSGAMEKSFKKYGSHTKKLSAHIKKRLLNSLDVIYDFKTPPATEIINIGKNWYECFAGGAHANIIMDLINTPFPDLQMAALSFLKTICKYNWGIVALKNTGGAVEFLLSRQKDLHRDIKYMKWQIMEILSASAEFSPTETIRFTAYVNEGPYHVQADLDVATEPQGNA", "length": 506 }, "evidence": [ { "id": "F1N6Z0", "url": "https://omabrowser.org/oma/group/F1N6Z0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome assembly", "id": "GO:0043248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043248", "evidence": [ { "database": "UniProtKB", "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0" } ], "pmid": "" }, { "name": "proteasome regulatory particle assembly", "id": "GO:0070682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070682", "evidence": [ { "database": "UniProtKB", "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "proteasome regulatory particle, base subcomplex", "id": "GO:0008540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008540", "evidence": [ { "database": "UniProtKB", "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N6Z0", "url": "https://www.uniprot.org/uniprotkb/F1N6Z0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Z0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 554, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Z0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Z0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 402, "end_pos": 404 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6J4-1", "uniprot_ac": "F1N6J4", "uniprot_id": "F1N6J4_BOVIN", "mass": { "chemical_mass": 80132.0, "monoisotopic_mass": 80132.0 }, "refseq": { "ac": "NP_001179472", "name": "E3 ubiquitin-protein ligase DCST1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179472" }, "gene_names": [ { "name": "DCST1", "type": "recommended", "evidence": [ { "id": "F1N6J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ] }, { "name": "DCST1", "type": "synonym", "evidence": [ { "id": "NP_001179472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179472" } ] } ], "protein_names": [ { "name": "DC-STAMP domain containing 1", "type": "synonym", "evidence": [ { "id": "F1N6J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J4/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase DCST1", "type": "synonym", "evidence": [ { "id": "NP_001179472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179472" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCST1", "url": "https://www.uniprot.org/uniprotkb/F1N6J4", "locus": { "chromosome": "3", "start_pos": 15548812, "end_pos": 15564300, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010655", "url": "https://www.ensembl.org/id/ENSBTAG00000010655" } ] } } ], "crossref": [ { "id": "F1N6J4", "url": "https://alphafold.ebi.ac.uk/entry/F1N6J4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010655", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010655", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521797", "url": "https://www.ncbi.nlm.nih.gov/gene/521797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521797", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHEVRFN", "url": "https://omabrowser.org/oma/group/EHEVRFN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6J4", "url": "https://www.orthodb.org/?gene=F1N6J4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21041", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21041", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21041:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21041:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179472", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SA17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N6J4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIRPHQNRAKGQRKLPHTTVQGFLNWGLPRSCNQFLWRQPGEFPVSAFLLGAGTGGLLAIGLFQLLVNPMNIYEDQKMVTLYSLVGLGVIGWGTSPHIRCASLLLIPKMLGKEGRLFVLGYALAAIYEGPVANLRHNLNAVIASLGCTVELQINNTRTAWRISTAPLRAVFKDLLSSKESLKAETQNITNSFEELDVQVNSESGFSPKDAEGSETAPGEEAPAASAFRHHLSTQKTYELKTKLRCSYVVNEAMFSCRRWFDQKHGVCMQRIWVPLLNHLLCLPMKFKFFCSIAKVMEVWCRSRIPVEGNFGQTYDSLNQSIHGLEGEFSATINLKEERRAGVLGLNTSWKHVSTEVRDYVRRQEAQLERTLGLLHVLLSCTFLLVLHSCFSYMDSYNGDIRFDNIYISTYFCQIDERRKKLGKQTLLPLRKAEKKTVIFPWDPTIQAAEMRNVLRELVETLPVLLLLLLLCGLDWALYSIFDTIRHHSFVQYSFRSSHKLEVKVGGDSMLARLLRNTIGALNTSSEMVVDSNNMPCLPQPVPLNTRAYLKAALPSGLLACLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLRKRAAFTQLRRATIVRRARQQRAPRRHLVDILHRRCPLLRPLLRRRCVVCQAPETPESYVCPTPNCEAVYCRSCWNDMRQRCPVCTPREELSSSAYSDSNDDATYAE", "length": 704, "header": "tr|F1N6J4-1|F1N6J4_BOVIN Isoform 1 of DC-STAMP domain containing 1 OS=Bos taurus OX=9913 GN=DCST1 PE=4 SV=3 CANONICAL=F1N6J4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA17/entry", "sequence": { "sequence": "MAIRPHQNRAKGQRKLPHTTVQGFLNWGLPRSCNQFLWRQPGEFPVSAFLLGAGTGGLLAIGLGVIGWGTSPHIRCASLLLIPKMLGKEGRLFVLGYALAAIYEGPVANLRHNLNAVIASLGCTVELQINNTRTAWRISTAPLRAVFKDLLSSKESLKAETQNITNSFEELDVQVNSESGFSPKDAEGSETAPGEEAPAASAFRHHLSTQKTYELKTKLRCSYVVNEAMFSCRRWFDQKHGVCMQRIWVPLLNHLLCLPMKFKFFCSIAKVMEVWCRSRIPVEGNFGQTYDSLNQSIHGLEGEFSATINLKEERRAGVLGLNTSWKHVSTEVRDYVRRQEAQLERTLGLLHVLLSCTFLLVLHSCFSYMDSYNGDIRFDNIYISTYFCQIDERRKKLGKQTLLPLRKAEKKTVIFPWDPTIQAAEMRNVLRELVETLPVLLLLLLLCGLDWALYSIFDTIRHHSFVQYSFRSSHKLEVKVGGDSMLARLLRNTIGALNTSSEMVVDSNNMPCLPQPVPLNTRAYLKAALPSGLLACLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLRKRAAFTQLRRATIVRRARQQRAPRRHLVDILHRRCPLLRPLLRRRCVVCQAPETPESYVCPTPNCEAVYCRSCWNDMRQRCPVCTPREELSSSAYSDSNDDATYAE", "length": 679, "header": "tr|A0AAA9SA17-1|F1N6J4_BOVIN Computationally mapped isoform of DC-STAMP domain containing 1 OS=Bos taurus OX=9913 GN=DCST1 PE=4 SV=1 CANONICAL=F1N6J4-1" }, "locus": { "chromosome": "3", "start_pos": 15564300, "end_pos": 15548877, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106548.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106548.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082155.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082155.1" } ] } }, { "isoform_ac": "F1N6J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N6J4/entry", "sequence": { "sequence": "MAIRPHQNRAKGQRKLPHTTVQGFLNWGLPRSCNQFLWRQPGEFPVSAFLLGAGTGGLLAIGLFQLLVNPMNIYEDQKMVTLYSLVGLGVIGWGTSPHIRCASLLLIPKMLGKEGRLFVLGYALAAIYEGPVANLRHNLNAVIASLGCTVELQINNTRTAWRISTAPLRAVFKDLLSSKESLKAETQNITNSFEELDVQVNSESGFSPKDAEGSETAPGEEAPAASAFRHHLSTQKTYELKTKLRCSYVVNEAMFSCRRWFDQKHGVCMQRIWVPLLNHLLCLPMKFKFFCSIAKVMEVWCRSRIPVEGNFGQTYDSLNQSIHGLEGEFSATINLKEERRAGVLGLNTSWKHVSTEVRDYVRRQEAQLERTLGLLHVLLSCTFLLVLHSCFSYMDSYNGDIRFDNIYISTYFCQIDERRKKLGKQTLLPLRKAEKKTVIFPWDPTIQAAEMRNVLRELVETLPVLLLLLLLCGLDWALYSIFDTIRHHSFVQYSFRSSHKLEVKVGGDSMLARLLRNTIGALNTSSEMVVDSNNMPCLPQPVPLNTRAYLKAALPSGLLACLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLRKRAAFTQLRRATIVRRARQQRAPRRHLVDILHRRCPLLRPLLRRRCVVCQAPETPESYVCPTPNCEAVYCRSCWNDMRQRCPVCTPREELSSSAYSDSNDDATYAE", "length": 704, "header": "tr|F1N6J4-1|F1N6J4_BOVIN Isoform 1 of DC-STAMP domain containing 1 OS=Bos taurus OX=9913 GN=DCST1 PE=4 SV=3 CANONICAL=F1N6J4-1" }, "locus": { "chromosome": "3", "start_pos": 15564300, "end_pos": 15548877, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014083.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014083.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014083.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014083.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 660, "start_aa": "Thr", "end_pos": 660, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr660", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZE12-1", "protein_name": "DC-STAMP domain containing 1", "gene_name": "Dcst1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLDFSSPEGHSMSVLTMAAGTKCQCVSSWRFFRFCGAWNSSSCSKFCRLVRWVCLRTRCSPVLRAQGAEELKDTGQSWAVCEAKHTGDMSFLSSTFHSLGIFEKISGIKEALKNRLLDITQRQYRAGGQQRKRPHTIIQGLLRWGLPVSWSRFLWRQPGEFPVTAFLLGTGTGGLLAIGLFQLLVNPMNIYEEQKVVALYGLTSLGAIGWGISPHIRCASLLLVPKMLGKEGRLFIMGYALASIYKGPVANLQYNINEVIASLGCTVELQINNTRSAWRVSTAPLRAVFKDMLSSKDSLKTEIANVSTSFEDLDAQVESNIGYSPEDKDMDTAPGTKALGTGTSRARLHLSTQMVYELKTKLRCSHVVNKAILSCYRWFDKKHQRCMQRIQVPLLNSLLCLPMKFKFFCNIAKVMEIWCHKRIPVEGNFGQTYDSVNQSIHGLSGEFSANIDIKEQKQSAVVGLSTNWEHVSVEVRDYAHQQEARLQWAVGLMHVLLSCTFLLVFHAAFSYMDNYNWDIRFDNIYISTYFYQIDARRKKLGKQSLLPLRKAEKTSVIFPLKATIQATEMRNVIRELLETLPILLLLLVLFAIDWVLYSIFDTIGHHSFVQYSFRSSHKLEINVEGDSILARLLRKTIGALNTTSDTEMETNNMPCLPRAVGLSAGGYFRASLPTCLLMCVCLAQAFGYRLRRVIAAFYFPKREKKRVLFLYNELLRKRSAFTKLRRAAIVRRARQQTTPRPPVVDALYRRCPLLRRLTRRRCVVCQALETPESYVCPTPDCKALYCRSCWDDMQRQCPVCTPREELSSSAHSDSNDDTVYGE", "length": 822 }, "evidence": [ { "id": "F1N6J4", "url": "https://omabrowser.org/oma/group/F1N6J4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q059Y8-1", "protein_name": "E3 ubiquitin-protein ligase DCST1", "gene_name": "Dcst1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLSSTLHSLGIFEKISRIKEVLKNRLLDLTKRRDQAREQQRKRPHTIIQGLLLWSLPVSWIRFLWRQPGEFPVTAFLLGAGTGGLLAIGLFQLLVNPMNIYEEQKVVALYCLASLGAIGWGTSPHIRCASLLLVPKMLGKEGRLFVMGYALAAIYSGPAANLRSNINEVIASLGCTVELQINNTRSAWRVSTAPLRAVFKGMVGSKDSLNKEIQNVSTSFEEMDEQVKSDAGYSSEDWDKNRESTEMFGTSRVRPYLSTQMVYELRTRLRCIHVVNKAILSCYRWFDKKHKNCMRRIHLPLFNNMICVPMKFKFLCNIAKVIEIWCYKRIPVEGNFGQTYDSVNQSIHGLSGEFSANINLKEEKQSSMVGLNTTNWEHMGTEVRDYVRQQETYLQWAMGLLHVLLSCTFLLVFHSAFSYMDHYNWDIRFDNIYISTYFCQIDARRKKLGKQSLLPLRKAERKTVIFPFKATIQAWEMRYVIRELLETLPIVLLLLVLCAIDWALYSVFDTIRQHSFVQYSFRSSHKLEIKVEGDSILAKLLRKTIGALNTSSSTDVETNNMPCLPQPISLNARDYFKASLPTLLLVCLCLAQAFGYRLRRVIAAFYFPKREKKRALFFYNEFLKKRSAFTKLRRAAIVRRANQQKAPPHYLVEALYRRCPLLHRFMRQRCVVCQAMETPDSYVCPTPDCKALYCRSCWDDMQRLCPVCTPREELSSSAHSDSNDDAVYGD", "length": 732 }, "evidence": [ { "id": "F1N6J4", "url": "https://omabrowser.org/oma/group/F1N6J4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T197-1", "protein_name": "E3 ubiquitin-protein ligase DCST1", "gene_name": "DCST1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDIKHHQNGTRGQRRKQPHTTVQRLLTWGLPVSCSWFLWRQPGEFPVTALLLGAGAGGLLAIGLFQLLVNPMNIYEEQKIMFLYSLVGLGAMGWGTSPHIRCASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNTRAAWRISTAPLRAMFKDLLSSKELLRAETRNISATFEDLDAQVNSETGYTPEDTMDSGETAQGREARQAPASRLHLSTQKMYELKTKLRCSYVVNQAILSCRRWFDRKHEQCMKHIWVPLLTHLLCLPMKFKFFCGIAKVMEVWCRNRIPVEGNFGQTYDSLNQSIRGLDGEFSANIDFKEEKQAGVLGLNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHASFSYMDSYNHDIRFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQASEMSNVVRELLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVGGDSMLARLLRKTIGALNTSSETVMESNNMPCLPQPVGLDARAYWRAAVPIGLLVCLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLKKRAAFTKLRRAAILRRERQQKAPRHPLADILHRGCPLLRRWLCRRCVVCQAPETPESYVCRTLDCEAVYCWSCWDDMRQRCPVCTPREELSSSAFSDSNDDTAYAG", "length": 706 }, "evidence": [ { "id": "F1N6J4", "url": "https://omabrowser.org/oma/group/F1N6J4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VU52-1", "protein_name": "Protein sneaky", "gene_name": "snky", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLSLLTRPFLPIFCFLYGPQSEGSTRIQCLRRFVTFLLGLVLGFLLWKLAALNFTLGRLFVNGATDLYVFIIFVLVTGTIFMLSLPVRAVILLIFVALVGKSGRTYLRAVAFAFIISGPIANLVENAGEVARVFVCTTVLTYNLSKTRFDLMAKPFTNTLKHMRGDVEEIRHTFYELQEVLVDLKYAVENSDIEDEKYGDKNTKPIYERWGRETSRMNVSEIGNGGKELPTPAAVQERFQRNMRNRCKHQLRSGHRACLEVFRNGYRKCTTNFPSMIAKAICWPYRVDIICELDLFGNPDKICDPSAVVPQNFGETYVELLKAEKKLFDNSSQIVVNYEIKDEQFAKSQLKSAERTGQAFKEDFERQKRIFNKVMGILQKILCLFMLRMVYVSINYYVKYLNDVEFDNFYITKYFKHVDQRRKEQRIDAILPLRTYEKSKYIDVDHIFSRTHHESTTVCFNLLQFLLELVTAGLFILIDHLVVELLQIVRKRSKIVYQQDGEHEVRFNISGVGQMARLLRTTMHNFNIHEKVSTSLSNKECLPNAHVLPKKMYYQLILLYLIIIVLIYQSTTFLRMRRVICSFFYYKREKQRILFLYNRILRNRLRSLEFLIHDAEDNLATHRIQQQVNVFLWLRFSCPVAFGWIRHFKFAKRTCMICRGLEDSTFTVCGNCGLPYCDDCAEDLNSVCFQCGVVLTRGAEGSESSVEVYTYRKEK", "length": 715 }, "evidence": [ { "id": "F1N6J4", "url": "https://omabrowser.org/oma/group/F1N6J4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "sperm-egg recognition", "id": "GO:0035036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035036", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" }, { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" }, { "name": "negative regulation of type I interferon-mediated signaling pathway", "id": "GO:0060339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060339", "evidence": [ { "database": "UniProtKB", "id": "F1N6J4", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6J4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 704, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6J4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6J4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J4" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 644, "end_pos": 683, "start_aa": "Cys", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 660 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 523, "end_pos": 525 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Q0-1", "uniprot_ac": "F1N6Q0", "uniprot_id": "F1N6Q0_BOVIN", "mass": { "chemical_mass": 64827.0, "monoisotopic_mass": 64827.0 }, "refseq": {}, "gene_names": [ { "name": "DNAJA4", "type": "recommended", "evidence": [ { "id": "F1N6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ] } ], "protein_names": [ { "name": "DnaJ heat shock protein family (Hsp40) member A4", "type": "synonym", "evidence": [ { "id": "F1N6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJA4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0", "locus": { "chromosome": "21", "start_pos": 30669870, "end_pos": 30652221, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015942", "url": "https://www.ensembl.org/id/ENSBTAG00000015942" } ] } } ], "crossref": [ { "id": "F1N6Q0", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Q0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015942", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015942", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10719", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10719", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N6Q0", "url": "https://www.orthodb.org/?gene=F1N6Q0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43888", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43888", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00684", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00684", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01556", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01556", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3371497", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SAB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q0-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTKQRTATPPGRGRVGNAGRSPPSPTPWGRVPANAALQATRSSSRPDPRTRGRERGRPRVGGTAVGRRPPRRSRLPNTRTWPGAAVSTGAPESQTGGRRSRRPRIPGEPEGCRAGPGRRESRPRTCSRAPAHQVQAPPEPPRRFWAFVASLSPCGTFRRRRIKPAAEEPAARVRRCRARRDKMVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDIYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPVCKGRGMQIHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCNGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDDRVLVITSKSGEVIKHGDLKCVRNEGMPIYKSPLEKGILIIQFLVIFPEKHWLPQDKLSQLEALLPPRQKVRITEDMDQVELKEFNPNEQNWRQHREAYEEDDDGPRAGVQCQTA", "length": 579, "header": "tr|F1N6Q0-1|F1N6Q0_BOVIN Isoform 1 of DnaJ heat shock protein family (Hsp40) member A4 OS=Bos taurus OX=9913 GN=DNAJA4 PE=3 SV=4 CANONICAL=F1N6Q0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB6/entry", "sequence": { "sequence": "MVLASATGPKTRPRDLRQATRSSSRPDPRTRGRERGRPRVGGTAVGRRPPRRSRLPNTRTWPGAAVSTGAPESQTGGRRSRRPRIPGEPEGCRAGPGRRESRPRTCSRAPAHQVQAPPEPPRRFWAFVASLSPCGTFRRRRIKPAAEEPAARVRRCRARRDKMVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDIYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPVCKGRGMQIHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCNGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDDRVLVITSKSGEVIKHGDLKCVRNEGMPIYKSPLEKGILIIQFLVIFPEKHWLPQDKLSQLEALLPPRQKVRITEDMDQVELKEFNPNEQNWRQHREAYEEDDDGPRAGVQCQTA", "length": 559, "header": "tr|A0AAA9SAB6-1|F1N6Q0_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member A4 OS=Bos taurus OX=9913 GN=DNAJA4 PE=3 SV=1 CANONICAL=F1N6Q0-1" }, "locus": { "chromosome": "21", "start_pos": 30668109, "end_pos": 30652420, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100741.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100741.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080854.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080854.1" } ] } }, { "isoform_ac": "F1N6Q0-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0/entry", "sequence": { "sequence": "MTKQRTATPPGRGRVGNAGRSPPSPTPWGRVPANAALQATRSSSRPDPRTRGRERGRPRVGGTAVGRRPPRRSRLPNTRTWPGAAVSTGAPESQTGGRRSRRPRIPGEPEGCRAGPGRRESRPRTCSRAPAHQVQAPPEPPRRFWAFVASLSPCGTFRRRRIKPAAEEPAARVRRCRARRDKMVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDIYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPVCKGRGMQIHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCNGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDDRVLVITSKSGEVIKHGDLKCVRNEGMPIYKSPLEKGILIIQFLVIFPEKHWLPQDKLSQLEALLPPRQKVRITEDMDQVELKEFNPNEQNWRQHREAYEEDDDGPRAGVQCQTA", "length": 579, "header": "tr|F1N6Q0-1|F1N6Q0_BOVIN Isoform 1 of DnaJ heat shock protein family (Hsp40) member A4 OS=Bos taurus OX=9913 GN=DNAJA4 PE=3 SV=4 CANONICAL=F1N6Q0-1" }, "locus": { "chromosome": "21", "start_pos": 30668109, "end_pos": 30653081, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021199.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021199.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021199.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021199.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 26, "start_aa": "Thr", "end_pos": 26, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr26", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "Hsp70 protein binding", "id": "GO:0030544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "ATPase activator activity", "id": "GO:0001671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001671", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "response to heat", "id": "GO:0009408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009408", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "negative regulation of inclusion body assembly", "id": "GO:0090084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090084", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "cellular response to heat", "id": "GO:0034605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034605", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell migration", "id": "GO:0010596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010596", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" }, { "name": "protein refolding", "id": "GO:0042026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q0", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Q0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Q0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Q0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" }, { "id": "PS51188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CR-type", "eco_id": "ECO_0000259", "start_pos": 304, "end_pos": 388, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q0" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 188, "end_pos": 250, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 26 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7V2-1", "uniprot_ac": "F1N7V2", "uniprot_id": "F1N7V2_BOVIN", "mass": { "chemical_mass": 23932.0, "monoisotopic_mass": 23932.0 }, "refseq": { "ac": "XP_024846042", "name": "ras-related protein Rab-17 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846042" }, "gene_names": [ { "name": "RAB17", "type": "recommended", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "name": "RAB17", "type": "synonym", "evidence": [ { "id": "XP_024846042", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846042" } ] } ], "protein_names": [ { "name": "Ras-related protein Rab-17", "type": "recommended", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2/entry#names_and_taxonomy" } ] }, { "name": "ras-related protein Rab-17 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024846042", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846042" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB17", "url": "https://www.uniprot.org/uniprotkb/F1N7V2", "locus": { "chromosome": "3", "start_pos": 117009976, "end_pos": 117057332, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017624", "url": "https://www.ensembl.org/id/ENSBTAG00000017624" } ] } } ], "crossref": [ { "id": "F1N7V2", "url": "https://alphafold.ebi.ac.uk/entry/F1N7V2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017624", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017624", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01860", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01860", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616956", "url": "https://www.ncbi.nlm.nih.gov/gene/616956", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616956", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616956", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCCKVGP", "url": "https://omabrowser.org/oma/group/SCCKVGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR47979", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47979", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8873719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024846042", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846042", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7V2-1", "url": "https://www.uniprot.org/uniprotkb/F1N7V2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQVNGVPRPGAALGQPCIFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDLGAACLKFEIWDTAGQEKYHSVCRLYFRGANAALLVYDITRKDSFCKAQQWLKDLEEEFHPGEVVVMLVGNKTDLEEEREVTFEEGKEFAESKGLLFMETSAKRNYQVADVFNAVARELSRREESKEGQRQRRDAPLTLSERPSWRGRCCAH", "length": 213, "header": "tr|F1N7V2-1|F1N7V2_BOVIN Isoform 1 of Ras-related protein Rab-17 OS=Bos taurus OX=9913 GN=RAB17 PE=3 SV=3 CANONICAL=F1N7V2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC3/entry", "sequence": { "sequence": "MSCPLPGGGPLALRKRRTWEAGTGLRLGWGQSQKDGRTASRTSPDKGTKTCLCAAEREQRRGRQGHHAQVCSCAFFTKVVDLGAACLKFEIWDTAGQEKYHSVCRLYFRGANAALLVYDITRKDSFCKAQQWLKDLEEEFHPGEVVVMLVGNKTDLEEEREVTFEEGKEFAESKGLLFMETSAKRNYQVADVFNAVARELSRREESKEGQRQRRDAPLTLSERPSWRGRCCAH", "length": 233, "header": "tr|A0AAA9SBC3-1|F1N7V2_BOVIN Computationally mapped isoform of Ras-related protein Rab-17 OS=Bos taurus OX=9913 GN=RAB17 PE=3 SV=1 CANONICAL=F1N7V2-1" }, "locus": { "chromosome": "3", "start_pos": 117057322, "end_pos": 117021068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096306.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096306.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083390.1" } ] } }, { "isoform_ac": "A0AAA9SMJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ3/entry", "sequence": { "sequence": "MHRSARGMAQVNGVPRPGAALGQPCIFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDLGAACLKFEIWDTAGQEKYHSVCRLYFRGANAALLVYDITRKDSFCKAQQWLKDLEEEFHPGEVVVMLVGNKTDLEEEREVTFEEGKEFAESKGLLFMETSAKRNYQVADVFNAVARELSRREESKEGQRQRRDAPLTLSERPSWRGRCCAH", "length": 220, "header": "tr|A0AAA9SMJ3-1|F1N7V2_BOVIN Computationally mapped isoform of Ras-related protein Rab-17 OS=Bos taurus OX=9913 GN=RAB17 PE=3 SV=1 CANONICAL=F1N7V2-1" }, "locus": { "chromosome": "3", "start_pos": 117057123, "end_pos": 117021068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110369.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110369.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086520.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086520.1" } ] } }, { "isoform_ac": "A0AAA9TN48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN48/entry", "sequence": { "sequence": "MHRSARGMAQVNGVPRPGAALGQPCIFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDLGAACLKFEIWDTAGQEKYHSVCRLYFRGANAALLVYDITRKDSFCKAQQWLKDLEEEFHPGEVVVMLVGNKTDLEEEREVTFEEGKEFAESKGLLFMETSAKRNYQVADVFNAVALSRVIIITAERSLL", "length": 198, "header": "tr|A0AAA9TN48-1|F1N7V2_BOVIN Computationally mapped isoform of Ras-related protein Rab-17 OS=Bos taurus OX=9913 GN=RAB17 PE=3 SV=1 CANONICAL=F1N7V2-1" }, "locus": { "chromosome": "3", "start_pos": 117057123, "end_pos": 117010980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112917.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112917.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099938.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099938.1" } ] } }, { "isoform_ac": "F1N7V2-1", "url": "https://www.uniprot.org/uniprotkb/F1N7V2/entry", "sequence": { "sequence": "MAQVNGVPRPGAALGQPCIFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDLGAACLKFEIWDTAGQEKYHSVCRLYFRGANAALLVYDITRKDSFCKAQQWLKDLEEEFHPGEVVVMLVGNKTDLEEEREVTFEEGKEFAESKGLLFMETSAKRNYQVADVFNAVARELSRREESKEGQRQRRDAPLTLSERPSWRGRCCAH", "length": 213, "header": "tr|F1N7V2-1|F1N7V2_BOVIN Isoform 1 of Ras-related protein Rab-17 OS=Bos taurus OX=9913 GN=RAB17 PE=3 SV=3 CANONICAL=F1N7V2-1" }, "locus": { "chromosome": "3", "start_pos": 117034051, "end_pos": 117021068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042655.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042655.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040290.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040290.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616956", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616956", "resource": "KEGG Pathway" }, { "id": "R-BTA-8873719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "resource": "Reactome", "description": "RAB geranylgeranylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YDI7-1", "protein_name": "Ras-related protein Rab-17", "gene_name": "RAB17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSASGFEVFRSRNAVLEYLIPTTPGASLHQASIKLKDMAQTAVPGSSLGNNRPTYIYKMVLLGSTSVGKSSLAYRYVKNDFKESLPTVGCSFFTQTIQLETATIKLEIWDTAGQEKYHSVCHLYYRGAHAALLVYDLTNKETLNRAKQWLMELEKEFLPDEIVIALVGNKTDLADEREVAAEDGEEFARSRSLLFMETSAKSNHQVNDVFMAVAQELLRREGKKAAVPSTGDRQRLDLQASRTRRGCCHV", "length": 250 }, "evidence": [ { "id": "F1N7V2", "url": "https://omabrowser.org/oma/group/F1N7V2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2RZ46-1", "protein_name": "Ras-related protein Rab-17", "gene_name": "Rab17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQAGGLPQASPSSGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLPTVGCAFFTKVVDLGSSSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFHPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFMESSAKLNYQVSEIFNTIAQELLQRAGDGQSSSPQEGEAVVLNQGPTVRPRQCCA", "length": 213 }, "evidence": [ { "id": "F1N7V2", "url": "https://omabrowser.org/oma/group/F1N7V2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P35292-1", "protein_name": "Ras-related protein Rab-17", "gene_name": "Rab17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQAAGLPQASTASGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLPTVGCAFFTKVLDLGSSSLKLEIWDTAGQEKYQSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFQPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFMETSAKLNYQVSEIFNTVAQELLQRAGDTGSSRPQEGEAVALNQEPPIRQRQCCAR", "length": 214 }, "evidence": [ { "id": "F1N7V2", "url": "https://omabrowser.org/oma/group/F1N7V2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0T7-1", "protein_name": "Ras-related protein Rab-17", "gene_name": "RAB17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH", "length": 212 }, "evidence": [ { "id": "F1N7V2", "url": "https://omabrowser.org/oma/group/F1N7V2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 13, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "dendrite cytoplasm", "id": "GO:0032839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032839", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor", "id": "GO:0002415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002415", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "filopodium assembly", "id": "GO:0046847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046847", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "regulation of synapse assembly", "id": "GO:0051963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051963", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "regulation of filopodium assembly", "id": "GO:0051489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051489", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "melanosome transport", "id": "GO:0032402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032402", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "regulation of dendrite development", "id": "GO:0050773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050773", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "anterograde dendritic transport", "id": "GO:0098937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098937", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "plasma membrane bounded cell projection assembly", "id": "GO:0120031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120031", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1N7V2", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-BTA-8870466", "name": "RGGT:CHM binds RABs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870466" } ] }, { "id": "R-BTA-8870469", "name": "RGGT geranylgeranylates RAB proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1131164" ], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870469", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870469" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1131164", "participant_name": "geranylgeranyl diphosphate [cytosol]", "crossref": [ { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000012495043", "database": "ZINC", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1MWA3", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N7V2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 213, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N7V2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N7V2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 50 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4R7-1", "uniprot_ac": "F1N4R7", "uniprot_id": "F1N4R7_BOVIN", "mass": { "chemical_mass": 43903.0, "monoisotopic_mass": 43903.0 }, "refseq": { "ac": "XP_024833666", "name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833666" }, "gene_names": [ { "name": "MGAT4D", "type": "recommended", "evidence": [ { "id": "F1N4R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ] }, { "name": "MGAT4D", "type": "synonym", "evidence": [ { "id": "XP_024833666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833666" } ] } ], "protein_names": [ { "name": "MGAT4 family member D", "type": "synonym", "evidence": [ { "id": "F1N4R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4R7/entry#names_and_taxonomy" } ] }, { "name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024833666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833666" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MGAT4D", "url": "https://www.uniprot.org/uniprotkb/F1N4R7", "locus": { "chromosome": "17", "start_pos": 17265932, "end_pos": 17214816, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034281", "url": "https://www.ensembl.org/id/ENSBTAG00000034281" } ] } } ], "crossref": [ { "id": "F1N4R7", "url": "https://alphafold.ebi.ac.uk/entry/F1N4R7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034281", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034281", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101907024", "url": "https://www.ncbi.nlm.nih.gov/gene/101907024", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101907024", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907024", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12062", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12062", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12062:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12062:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04666", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04666", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833666", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833666", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4R6", "url": "https://www.uniprot.org/uniprotkb/F1N4R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4R6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4R7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4R7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTRHVNLLITLIAVVLFSFSCFCISRMTQTSNQLTNCRNHISEFKESILRLKNKTERNRQELLNAFKEMKLDISEKERDAQNAVEKKVNASDTNETVSDAFEVLKFFFPHLRKVDRIYPDVIMGREKTGVTFALGISTVNRGNYSYLKQTLTSILSRMTLPEEKDSVVIVSIADSNENYVKSVVDMITKKFKRQVTSGSLEVISIPAYFYPNISHAARSTDDSEKLESWRIKQVLDFCFLMLYAQPKAMYYLQLEDDILANKMYLTKITDFVHNITSNNWLYIEFSVLGFIGKLFKSEDLTDFVRFFLMFYKDKPIDLLLGDIFLVKMCTPGEALEKCIERNKHIRIRYKPSLFQHVGIQSSYPGREQYFKDIYY", "length": 376, "header": "tr|F1N4R7-1|F1N4R7_BOVIN Isoform 1 of MGAT4 family member D OS=Bos taurus OX=9913 GN=MGAT4D PE=4 SV=4 CANONICAL=F1N4R7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG3/entry", "sequence": { "sequence": "MRTRHVNLLITLIAVVLFSFSCFCISRMTQTSNQLTNCRNHISEFKESILRLKNKTERNRQELLNAFKEMKLDISEKERDAQNAGKLFKSEDLTDFVRFFLMFYKDKPIDLLLGDIFLVKMCTPGEALEKCIERNKHIRIRYKPSLFQHVGIQSSYPGREQYFKEI", "length": 166, "header": "tr|A0AAA9SBG3-1|F1N4R7_BOVIN Computationally mapped isoform of MGAT4 family member D OS=Bos taurus OX=9913 GN=MGAT4D PE=4 SV=1 CANONICAL=F1N4R7-1" }, "locus": { "chromosome": "17", "start_pos": 17265929, "end_pos": 17214946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108295.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108295.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082728.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082728.1" } ] } }, { "isoform_ac": "F1N4R6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4R6/entry", "sequence": { "sequence": "MRTRHVNLLITLIAVVLFSFSCFCISRMTQTSNQLTNCRNHISEFKESILRLKNKTERNRQELLNAFKEMKLDISEKERDAQNAVEKKVNASDTNETVSDAFEVLKFFFPHLRKVDRIYPDVIMGREKTGVTFALGISTVNRGNYSYLKQTLTSILSRMTLPEEKDSVVIVSIADSNENYVKSVVDMITKKFKRQVTSGSLEVISIPAYFYPNISHAARSTDDSEKLESWRIKQVLDFCFLMLYAQPKAMYYLQLEDDILANKMYLTKITDFVHNITSNNWLYIEFSVLGFIGKLFKSEDLTDFVRFFLMFYKDKPIDLLLGDIFLVKMCTPGEALEKCIERNKHIRIRYKPSLFQHVGIQSSYPGREQYFKEI", "length": 374, "header": "tr|F1N4R6-1|F1N4R7_BOVIN Computationally mapped isoform of MGAT4 family member D OS=Bos taurus OX=9913 GN=MGAT4D PE=4 SV=4 CANONICAL=F1N4R7-1" }, "locus": { "chromosome": "17", "start_pos": 17265929, "end_pos": 17214946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048576.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048576.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045589.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045589.5" } ] } }, { "isoform_ac": "F1N4R7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4R7/entry", "sequence": { "sequence": "MRTRHVNLLITLIAVVLFSFSCFCISRMTQTSNQLTNCRNHISEFKESILRLKNKTERNRQELLNAFKEMKLDISEKERDAQNAVEKKVNASDTNETVSDAFEVLKFFFPHLRKVDRIYPDVIMGREKTGVTFALGISTVNRGNYSYLKQTLTSILSRMTLPEEKDSVVIVSIADSNENYVKSVVDMITKKFKRQVTSGSLEVISIPAYFYPNISHAARSTDDSEKLESWRIKQVLDFCFLMLYAQPKAMYYLQLEDDILANKMYLTKITDFVHNITSNNWLYIEFSVLGFIGKLFKSEDLTDFVRFFLMFYKDKPIDLLLGDIFLVKMCTPGEALEKCIERNKHIRIRYKPSLFQHVGIQSSYPGREQYFKDIYY", "length": 376, "header": "tr|F1N4R7-1|F1N4R7_BOVIN Isoform 1 of MGAT4 family member D OS=Bos taurus OX=9913 GN=MGAT4D PE=4 SV=4 CANONICAL=F1N4R7-1" }, "locus": { "chromosome": "17", "start_pos": 17258205, "end_pos": 17214946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048574.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048574.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045587.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045587.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101907024", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907024", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" }, { "name": "Golgi stack", "id": "GO:0005795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005795", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "acetylglucosaminyltransferase activity", "id": "GO:0008375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008375", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" }, { "name": "negative regulation of glycoprotein biosynthetic process", "id": "GO:0010561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010561", "evidence": [ { "database": "UniProtKB", "id": "F1N4R7", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4R7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4R7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4R7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4R7" }, { "id": "PF04666", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04666" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MGAT4 conserved region", "eco_id": "ECO_0000259", "start_pos": 97, "end_pos": 375, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 213, "end_pos": 215 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 90, "end_pos": 92 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1C7-1", "uniprot_ac": "F1N1C7", "uniprot_id": "F1N1C7_BOVIN", "mass": { "chemical_mass": 131922.0, "monoisotopic_mass": 131922.0 }, "refseq": { "ac": "XP_024846888", "name": "adipocyte enhancer-binding protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846888" }, "gene_names": [ { "name": "AEBP1", "type": "recommended", "evidence": [ { "id": "F1N1C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ] }, { "name": "AEBP1", "type": "synonym", "evidence": [ { "id": "XP_024846888", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846888" } ] } ], "protein_names": [ { "name": "Adipocyte enhancer-binding protein 1", "type": "recommended", "evidence": [ { "id": "F1N1C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C7/entry#names_and_taxonomy" } ] }, { "name": "Aortic carboxypeptidase-like protein", "type": "synonym", "evidence": [ { "id": "F1N1C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C7/entry#names_and_taxonomy" } ] }, { "name": "adipocyte enhancer-binding protein 1", "type": "synonym", "evidence": [ { "id": "XP_024846888", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846888" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AEBP1", "url": "https://www.uniprot.org/uniprotkb/F1N1C7", "locus": { "chromosome": "4", "start_pos": 77200630, "end_pos": 77212311, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012237", "url": "https://www.ensembl.org/id/ENSBTAG00000012237" } ] } } ], "crossref": [ { "id": "F1N1C7", "url": "https://alphafold.ebi.ac.uk/entry/F1N1C7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012237", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11308", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11308", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "317693", "url": "https://www.ncbi.nlm.nih.gov/gene/317693", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:317693", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:317693", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VIMYIPE", "url": "https://omabrowser.org/oma/group/VIMYIPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1C7", "url": "https://www.orthodb.org/?gene=F1N1C7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11532", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11532", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11532:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11532:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846888", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846888", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALLGAPLLGCLLVLLALCPGGRPQTVLTDDEIEEFLEGFLSELESEPREDDVEAPPPPEPTLPARKPQTGGKPGARPGVAEEVPPGKAKDKGKKGKKDKSPKATKQPPEGSSRPPKKPKEKPPKEKPPKATKKPKEKPPKATKKPKEKQPKEKPPKEKPPKEKPPKATKKPKEKPPKATKRPLAGKKLSIPTPSESPQWPLPPLLSPDHEELPQEGGGPLPDPWGGPGEETDVEHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRPERPWPERPEEKAEPPGRGFEAPEEKIEPPPLKPLPPPLLPDYEDGYVIPNYDDMDYYFRPPKPQKPDTGLETDEEKEELKKPKKEGSSPKEEETDDKWTVEKGKDPKGPRKGEESEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGDTEDDYYDGAWCAEDDSQTQWIEVDTRRTTKFTGVITQGRDSSIHDDFVTSFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVSPVHSYYAQNEVVTTDDLDFRHHNYKDMRQLMKVVNEQCPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIYEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAAMAAARGEDEEEVSEAQETPDHAIFRWLAISFASTHLTMTEPYRGGCQAQDYTGGMGIVNGAKWKPRSGTINDFSYLHTNCLELSIFLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSSKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPRIDPSRPMTPQQRRMQRRRLQYRLRMREQMRLRRLNATTSPATTPTSPPPTPTLLPTADLAPSPAPSSTLGPWQFLPETTVNWEESETETETETETYTEVVTEFGTELGPEEEEGEEGEGEMVTGPDFPFTTVETYTVNFGDF", "length": 1170, "header": "tr|F1N1C7-1|F1N1C7_BOVIN Isoform 1 of Adipocyte enhancer-binding protein 1 OS=Bos taurus OX=9913 GN=AEBP1 PE=3 SV=3 CANONICAL=F1N1C7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL4/entry", "sequence": { "sequence": "MVPPGKAKDKGKKGKKDKSPKATKQPPEGSSRPPKKPKEKPPKEKPPKATKKPKEKPPKATKKPKEKQPKEKPPKEKPPKEKPPKATKKPKEKPPKATKRPLAGKKLSIPTPSESPQWPLPPLLSPDHEELPQEGGGPLPDPWGGPGEETDVEHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRPERPWPERPEEKAEPPGRGFEAPEEKIEPPPLKPLPPPLLPDYEDGYVIPNYDDMDYYFRPPKPQKPDTGLETDEEKEELKKPKKEGSSPKEEETDDKWTVEKGKDPKGPRKGEESEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGDTEDDYYDGAWCAEDDSQTQWIEVDTRRTTKFTGVITQGRDSSIHDDFVTSFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVSPVHSYYAQNEVVTTDDLDFRHHNYKDMRQLMKVVNEQCPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIYEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAAMAAARGEDEEEVSEAQETPDHAIFRWLAISFASTHLTMTEPYRGGCQAQDYTGGMGIVNGAKWKPRSGTINDFSYLHTNCLELSIFLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSSKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPRIDPSRPMTPQQRRMQRRRLQYRLRMREQMRLRRLNATTSPATTPTSPPPTPTLLPTADLAPSPAPSSTLGPWQFLPETTVNWEESETETETETETYTEVVTEFGTELGPEEEEGEEGEGEMVTGPDFPFTTVETYTVNFGDF", "length": 1087, "header": "tr|A0AAA9SBL4-1|F1N1C7_BOVIN Computationally mapped isoform of Adipocyte enhancer-binding protein 1 OS=Bos taurus OX=9913 GN=AEBP1 PE=3 SV=1 CANONICAL=F1N1C7-1" }, "locus": { "chromosome": "4", "start_pos": 77212114, "end_pos": 77200843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130174.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130174.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082783.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082783.1" } ] } }, { "isoform_ac": "A0AAA9TUG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUG6/entry", "sequence": { "sequence": "MAALLGAPLLGCLLVLLALCPGGRPQTVLTDDEIEEFLEGFLSELESEPREDDVEAPPPPEPTLPARKPQTGGKPGARPGVAEEVPPGKAKDKGKKGKKDKSPKATKQPPEGSSRPPKKPKEKPPKEKPPKATKKPKEKPPKATKRPLAGKKLSIPTPSESPQWPLPPLLSPDHEELPQEGGGPLPDPWGGPGEETDVEHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRPERPWPERPEEKAEPPGRGFEAPEEKIEPPPLKPLPPPLLPDYEDGYVIPNYDDMDYYFRPPKPQKPDTGLETDEEKEELKKPKKEGSSPKEEETDDKWTVEKGKDPKGPRKGEESEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGDTEDDYYDGAWCAEDDSQTQWIEVDTRRTTKFTGVITQGRDSSIHDDFVTSFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVSPVHSYYAQNEVVTTDDLDFRHHNYKDMRQLMKVVNEQCPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIYEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAAMAAARGEDEEEVSEAQETPDHAIFRWLAISFASTHLTMTEPYRGGCQAQDYTGGMGIVNGAKWKPRSGTINDFSYLHTNCLELSIFLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSSKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPRIDPSRPMTPQQRRMQRRRLQYRLRMREQMRLRRLNATTSPATTPTSPPPTPTLLPTADLAPSPAPSSTLGPWQFLPETTVNWEESETETETETETYTEVVTEFGTELGPEEEEGEEGEGEMVTGPDFPFTTVETYTVNFGDF", "length": 1133, "header": "tr|A0AAA9TUG6-1|F1N1C7_BOVIN Computationally mapped isoform of Adipocyte enhancer-binding protein 1 OS=Bos taurus OX=9913 GN=AEBP1 PE=3 SV=1 CANONICAL=F1N1C7-1" }, "locus": { "chromosome": "4", "start_pos": 77209981, "end_pos": 77200843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102009.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102009.1" } ] } }, { "isoform_ac": "F1N1C7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C7/entry", "sequence": { "sequence": "MAALLGAPLLGCLLVLLALCPGGRPQTVLTDDEIEEFLEGFLSELESEPREDDVEAPPPPEPTLPARKPQTGGKPGARPGVAEEVPPGKAKDKGKKGKKDKSPKATKQPPEGSSRPPKKPKEKPPKEKPPKATKKPKEKPPKATKKPKEKQPKEKPPKEKPPKEKPPKATKKPKEKPPKATKRPLAGKKLSIPTPSESPQWPLPPLLSPDHEELPQEGGGPLPDPWGGPGEETDVEHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRPERPWPERPEEKAEPPGRGFEAPEEKIEPPPLKPLPPPLLPDYEDGYVIPNYDDMDYYFRPPKPQKPDTGLETDEEKEELKKPKKEGSSPKEEETDDKWTVEKGKDPKGPRKGEESEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGDTEDDYYDGAWCAEDDSQTQWIEVDTRRTTKFTGVITQGRDSSIHDDFVTSFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVSPVHSYYAQNEVVTTDDLDFRHHNYKDMRQLMKVVNEQCPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIYEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAAMAAARGEDEEEVSEAQETPDHAIFRWLAISFASTHLTMTEPYRGGCQAQDYTGGMGIVNGAKWKPRSGTINDFSYLHTNCLELSIFLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSSKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPRIDPSRPMTPQQRRMQRRRLQYRLRMREQMRLRRLNATTSPATTPTSPPPTPTLLPTADLAPSPAPSSTLGPWQFLPETTVNWEESETETETETETYTEVVTEFGTELGPEEEEGEEGEGEMVTGPDFPFTTVETYTVNFGDF", "length": 1170, "header": "tr|F1N1C7-1|F1N1C7_BOVIN Isoform 1 of Adipocyte enhancer-binding protein 1 OS=Bos taurus OX=9913 GN=AEBP1 PE=3 SV=3 CANONICAL=F1N1C7-1" }, "locus": { "chromosome": "4", "start_pos": 77209981, "end_pos": 77200843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033669.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033669.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033579.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033579.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1078, "start_aa": "Thr", "end_pos": 1078, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1078", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:317693", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:317693", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2RUV9-1", "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "Aebp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVRTASLLCGLLALLALCPEGSPQTVLTDDEIQEFLEGFLSEFETQSPPREDDVEAQPLPEPTQRARKSKAGGKPRADAEAPPEKNKDKEKKGKKDKGPKAAKHLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKRFSTVAPLETPERSLTSPSNPGTRELPEERGRTSLNTWQGQGEETQVEARQHRPEPEEETEMPTLDYNDQIEREDYEDFEYIRRQKQPRPTPSRKRIWPEPPEEKTQEPEERKEVDPPLKPLLPPDYGDGYLIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEELKKPKKEGSSPKEDTEDKWAAEKNKDHKAGPRKGEELEEEWGPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGMHGNEVLGRELLLLLMQYLCHEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAALAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRLQQRRLRYRLRMREQMRLRRLNSTTGPATSPTPALTLPPSPTPGSTSRLWEILPTTAAGWEESETETYTEVVTEFETEYGPDLEVEELEEEEEEEEEMDTGLTFPVTTVETYTVNFGDF", "length": 1128 }, "evidence": [ { "id": "F1N1C7", "url": "https://omabrowser.org/oma/group/F1N1C7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F829-1", "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "aebp1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRVLVCAALFALCWILTFAINEELANAPNQRTRSIQMRQSNGVKSNRDDLQEGFSEDTQMDEPGEEMAEKEKPKGKKTPEEILAAKAKKAAEKEAKAKKPKPTKKPKPTKKPKPPKATKKSKPPKATKKPKAAKPTTPARETKPTKKPTMEEEEEKLLLELGWDTLSPKETEMEKPIGPDHDMHSKKDPTTPPSVKEHMPDNWDSRHEIQEPDLIPKVKQPSSTDDPSIYLPIPEEATTTPRTIAPWYEEYDYADLAAKKQEEELEKARKAKEEKAEKLRKMWEEEEEEKRKQTALHAEPKKCPPLGLESHRVEDDQILASSSSNLGYSALRGRLNMQNSADEEDVYGGAWCADTEEKEHWFQVDGRREVEFTGVITQGRNSESNNDFVSSFFVAFSNDSREWTVLHDGYAEWLFYGNVDKDTPVMTEFSYPVVARYIRVLPQSWNGSLCMRLEVLGCQLPTSYATENDVPPTDDLDYRHHNYKEMRQMMKVINEECPNITRIYNIGKSFQGLKMYAMEISDNPGEHEPGEPEFRYTAGLHGNEVLGRELLLLLMQFICKEYNDDNPRVHRLVETVRIHLVPSLNPDAYELAYEMGSEMGNWALGHWTEEGYDIFQNFPDLNSVLWGAEDRGWVPRIVPNHHIPIPENFLNGSVATETKAIISWMERTPFVLGANLQGGEKLVAYPFDMQRPPRATSTDGRVGQPVQEYHNMNEETWARIQRQNEGALRETADENLFRWLATTYAHSHLTLTENHRGSCHTDDITGGQGIINRASWKPVVGSMNDFSYLHTNCFEISIFLGCDKFPHESELPSEWENNREALLAFIEQVHRGIKGVVRDVDGNLLANATVSVEGIKHDVKTASTGDYWRLLNPGEYRVTARADGYSSQTRLCIVGYDANATPCSFTLTKSNWARIQQILAQSGKRPRLVNNIPRNANNQVNGGSTGPAGGSQNERLNRIRLMRMRKLRMERMKSSTTTEMTTSTTTTTPEPTTTTTLGSTSESWYDWFEQESFNFEHTIDED", "length": 1022 }, "evidence": [ { "id": "F1N1C7", "url": "https://omabrowser.org/oma/group/F1N1C7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SSF7-1", "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "AEBP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVRGAPLLGCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELESEPREDDVEAPPPPEPTLPVRKAQAGGKPGARPGVAGEAPPGKAKDKGKKGKKDKGPKATKQPREGSPKPPKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPLAGKKHPIPTPSESPPWPLPPPPSPGLEELPQEGGGAPPNPWEGLGEDDGEHKPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRPERLWPERPEEKAEPPRRGFEAPEEKIEPPLKPLPPPLPDYGDGYVIPDYGDLDYYFQPPRPRKPDTGLETDEEKEELKKPKKEGGSRKEEDTDDKWAVDKGKDHKGPRKGEELEEEWAPVEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGATEDDYFDGAWCAEDDSQTQWIEVDTRRTTKFTGVITQGRDSSIHDDFVTSFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVSSVHSYYAQNEVVTTDDLDFRHHSYKDMRQLMKVVNEQCPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVHDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIYEDFPDLNSVLWGAEERKWVPFRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAAMAAARGEDEEEVSEAQETPDHAIFRWLAISFASTHLTMTEPYRGGCQAQDYTGGMGIVNGAKWKPRSGTINDFSYLHTNCLELSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSSKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRMQHRRLQYRLRMREQMRLRRLNATASLATTPTSPPTTPTLLPMPTLAPSPAPSSTLGPWHVVPETTAAWEESETETYTEVVTEFGTELGPEEEEEEEEGETATGSEFPFTTVETYTVNFGDF", "length": 1140 }, "evidence": [ { "id": "F1N1C7", "url": "https://omabrowser.org/oma/group/F1N1C7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q640N1-1", "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "Aebp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPVRTASLLCGLLALLTLCPEGNPQTVLTDDEIEEFLEGFLSELETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPKATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEERKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFYGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMKAVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETPDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRMQQRRLQYRLRMREQMRLRRLNSTAGPATSPTPALMPPPSPTPAITLRPWEVLPTTTAGWEESETETYTEVVTEFETEYGTDLEVEEIEEEEEEEEEEMDTGLTFPLTTVETYTVNFGDF", "length": 1128 }, "evidence": [ { "id": "F1N1C7", "url": "https://omabrowser.org/oma/group/F1N1C7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IUX7-1", "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "AEBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF", "length": 1158 }, "evidence": [ { "id": "F1N1C7", "url": "https://omabrowser.org/oma/group/F1N1C7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "metallocarboxypeptidase activity", "id": "GO:0004181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "carboxypeptidase activity", "id": "GO:0004180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004180", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" }, { "name": "regulation of collagen fibril organization", "id": "GO:1904026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904026", "evidence": [ { "database": "UniProtKB", "id": "F1N1C7", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1063, "end_pos": 1065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" }, { "start_pos": 946, "end_pos": 948, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1C7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1170, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1C7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1C7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" }, { "id": "PS50022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F5/8 type C", "eco_id": "ECO_0000259", "start_pos": 407, "end_pos": 564, "start_aa": "Ile", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C7" }, { "id": "PS52035", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M14", "eco_id": "ECO_0000259", "start_pos": 587, "end_pos": 928, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1078 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1063, "end_pos": 1065 }, { "start_pos": 504, "end_pos": 506 }, { "start_pos": 552, "end_pos": 554 }, { "start_pos": 946, "end_pos": 948 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6PRF2-1", "uniprot_ac": "F6PRF2", "uniprot_id": "F6PRF2_BOVIN", "mass": { "chemical_mass": 63153.0, "monoisotopic_mass": 63153.0 }, "refseq": {}, "gene_names": [ { "name": "CHST10", "type": "recommended", "evidence": [ { "id": "F6PRF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ] } ], "protein_names": [ { "name": "Carbohydrate sulfotransferase", "type": "recommended", "evidence": [ { "id": "F6PRF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PRF2/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "F6PRF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PRF2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6PRF2", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST10", "url": "https://www.uniprot.org/uniprotkb/F6PRF2", "locus": { "chromosome": "11", "start_pos": 5493519, "end_pos": 5522943, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004328", "url": "https://www.ensembl.org/id/ENSBTAG00000004328" } ] } } ], "crossref": [ { "id": "F6PRF2", "url": "https://alphafold.ebi.ac.uk/entry/F6PRF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004328", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004328", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HWPEEFQ", "url": "https://omabrowser.org/oma/group/HWPEEFQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJQ8", "url": "https://www.orthodb.org/?gene=A0A3Q1LJQ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1B8", "url": "https://www.orthodb.org/?gene=A0A3Q1M1B8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6PRF2", "url": "https://www.orthodb.org/?gene=F6PRF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-975578", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975578", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9939291", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9939291", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJQ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1B8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SET8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SET8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PRF2", "url": "https://www.uniprot.org/uniprotkb/F6PRF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PRF2-1", "url": "https://www.uniprot.org/uniprotkb/F6PRF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVTWWDKVWPHVPLSFPGIHSGGLLGRRLVWDWNSAARAGAEPGTGVSGPASLHLPLVDAAARARRGRRRGRAEPARSAHGADRRGGGGGLASRESFASKPSSFRRRRRRIPGREGRWRRPGLRAGFPRSRDAWAPRASPPGPRGPSRTKPPRPQKGPRTATAPAPLRLQEEPRTSGKADTARKCGSGSEGRIAEWLMFDNMHHQWLLLAACFWVILMFMVASKFITLTFKDPDAYSAKQEFLFLTAVPDAGRLPGETHFPEELKPTGKMLVEPLVYAQRLELMRNVCREDALRNLSHTAVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFPSIEEIPENVVHDHEKNGLPRLSSFSEAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEITYSVVGHHETLADDAPYILREAGIDHLVAYPTIPLGITAYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPEFLLN", "length": 552, "header": "tr|F6PRF2-1|F6PRF2_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST10 PE=3 SV=2 CANONICAL=F6PRF2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ8/entry", "sequence": { "sequence": "MFDNMHHQWLLLAACFWVILMFMVASKFITLTFKDPDAYSAKQEFLFLTAVPDAGRLPGETHFPEELKPTGKMLVEPLVYAQRLELMRNVCREDALRNLSHTAVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFPSIEEIPENVVHDHEKNGLPRLSSFSEAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEITYSVVGHHETLADDAPYILREAGIDHLVAYPTIPLGITAYNRTKVEQYFLGISKRDIRRLLPVWLTAVILKLSKPRLGQQHHIHTVYCPQGRVSLPATSFSKKFQEMTVVIFCRKAHHRLFTVLLCRRRLERFP", "length": 408, "header": "tr|A0A3Q1LJQ8-1|A0A3Q1LJQ8_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST10 PE=3 SV=2 CANONICAL=F6PRF2-1" }, "locus": { "chromosome": "11", "start_pos": 5513444, "end_pos": 5493602, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066485.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066485.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056792.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056792.2" } ] } }, { "isoform_ac": "A0A3Q1M1B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1B8/entry", "sequence": { "sequence": "MCSFLSAQLSTSAVGGPGGGNSCLENSMARGACQASIHGVAKSRMRLSTLALLQEEPRTSGKADTARKCGSGSEGRIAEWLMFDNMHHQWLLLAACFWVILMFMVASKFITLTFKDPDAYSAKQEFLFLTAVPDAGRLPGETHFPEELKPTGKMLVEPLVYAQRLELMRNVCREDALRNLSHTAVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFPSIEEIPENVVHDHEKNGLPRLSSFSEAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEITYSVVGHHETLADDAPYILREAGIDHLVAYPTIPLGITAYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPEFLLN", "length": 436, "header": "tr|A0A3Q1M1B8-1|A0A3Q1M1B8_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST10 PE=3 SV=2 CANONICAL=F6PRF2-1" }, "locus": { "chromosome": "11", "start_pos": 5522030, "end_pos": 5502439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082120.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082120.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063776.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063776.2" } ] } }, { "isoform_ac": "A0AAA9SET8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET8/entry", "sequence": { "sequence": "MMVRPGRIAEWLMFDNMHHQWLLLAACFWVILMFMVASKFITLTFKDPDAYSAKQEFLFLTAVPDAGRLPGETHFPEELKPTGKMLVEPLVYAQRLELMRNVCREDALRNLSHTAVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFPSIEEIPENVVHDHEKNGLPRLSSFSEAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEITYSVVGHHETLADDAPYILREAGIDHLVAYPTIPLGITAYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPEFLLN", "length": 367, "header": "tr|A0AAA9SET8-1|F6PRF2_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST10 PE=3 SV=1 CANONICAL=F6PRF2-1" }, "locus": { "chromosome": "11", "start_pos": 5517132, "end_pos": 5502439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099553.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099553.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082357.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082357.1" } ] } }, { "isoform_ac": "F6PRF2-1", "url": "https://www.uniprot.org/uniprotkb/F6PRF2/entry", "sequence": { "sequence": "MVTWWDKVWPHVPLSFPGIHSGGLLGRRLVWDWNSAARAGAEPGTGVSGPASLHLPLVDAAARARRGRRRGRAEPARSAHGADRRGGGGGLASRESFASKPSSFRRRRRRIPGREGRWRRPGLRAGFPRSRDAWAPRASPPGPRGPSRTKPPRPQKGPRTATAPAPLRLQEEPRTSGKADTARKCGSGSEGRIAEWLMFDNMHHQWLLLAACFWVILMFMVASKFITLTFKDPDAYSAKQEFLFLTAVPDAGRLPGETHFPEELKPTGKMLVEPLVYAQRLELMRNVCREDALRNLSHTAVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFPSIEEIPENVVHDHEKNGLPRLSSFSEAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEITYSVVGHHETLADDAPYILREAGIDHLVAYPTIPLGITAYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPEFLLN", "length": 552, "header": "tr|F6PRF2-1|F6PRF2_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST10 PE=3 SV=2 CANONICAL=F6PRF2-1" }, "locus": { "chromosome": "11", "start_pos": 5522918, "end_pos": 5502439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005667.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005667.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005667.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005667.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-975578", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975578", "resource": "Reactome", "description": "Reactions specific to the complex N-glycan synthesis pathway" }, { "id": "R-BTA-9939291", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9939291", "resource": "Reactome", "description": "Matriglycan biosynthesis on DAG1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z0K6-1", "protein_name": "Carbohydrate sulfotransferase", "gene_name": "CHST10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEQRSTWREGSNNLIWLMSDNMHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYGAKQEPLILTAVTKVEEAHVPEEKHWTKEFQPTGKAFTGNLLHHPLVHMERLELLRNVCRDTALRNLSHTAVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAYSSIDEIPESIVHDHEKNGLPRLSSFSDSEIKKRLNLYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPSIIRKYRRNRMETKGLQFEDFVRYLGDPNHRWLDVQFGDHIIHWVTYVELCAPCEITYSVIGHHETLEDDAPYILKAAGIDRLVSYPTIPPGITVYNKTKVERYFSGISKRDIRRLYARFEGDFKLFGYRVPDFLLN", "length": 380 }, "evidence": [ { "id": "F6PRF2", "url": "https://omabrowser.org/oma/group/F6PRF2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43529-1", "protein_name": "Carbohydrate sulfotransferase 10", "gene_name": "CHST10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFLTTMPEVRKLPEEKHIPEELKPTGKELPDSQLVQPLVYMERLELIRNVCRDDALKNLSHTPVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSDAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIMYSVIGHHETLEDDAPYILKEAGIDHLVSYPTIPPGITVYNRTKVEHYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN", "length": 356 }, "evidence": [ { "id": "F6PRF2", "url": "https://omabrowser.org/oma/group/F6PRF2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O54702-1", "protein_name": "Carbohydrate sulfotransferase 10", "gene_name": "Chst10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYSAKQEFVFLTAMPEAEKLRGEKHFSEVMKPTGKMLSESHPDQPPVYLERLELIRNACKEEALRNLSHTEVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSKIGIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRKNRTETRGIQFEDFVRYLGDPNRRWLDLQFGDHIIHWVTYVKLCAPCEIKYSVIGHHETLEADAPYILKEAGIDHLVSYPTIPPGITMYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN", "length": 356 }, "evidence": [ { "id": "F6PRF2", "url": "https://omabrowser.org/oma/group/F6PRF2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6AXM1-1", "protein_name": "Carbohydrate sulfotransferase 10", "gene_name": "chst10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRRHWLLVGACGWVLLILMFVSKFINFSFRIPGDYAGRSEIFVWTLSSVTTKLPSVVWPEKGASQPYILSSVSPSVVEPIDWHLVNEKRLEQLSTVCSNSSIWNLTHTTVRKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGKFSKVEAIPENLVHDHERNGLPRLSSMTDTEIHQRLNSYFKFFIVRDPFERLISAFKDKFVKNPRFEPWYKHDIAPAIVRKYRRSHHDDSESVGLRFEDFVRYLGDKTGRQHLDRQFGDHIIHWLTYAELCAPCDISYNVVGHHETLELDAPYILKSAGIAGLVSYPSIPPGITRYNRTKVERYFSGISQRDIRRLYARYQGDFSLFDYPKPAFLLN", "length": 365 }, "evidence": [ { "id": "F6PRF2", "url": "https://omabrowser.org/oma/group/F6PRF2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6PGK7-1", "protein_name": "Carbohydrate sulfotransferase 10", "gene_name": "Chst10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYSAKQEFVFLTTMPEAEKLRGEKHFPEVPKPTGKMLSDSRPDQPPVYLERLELIRNTCKEEALRNLSHTEVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSKIGIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRKNRTETRGIQFEDFVRYLGDPNRRWLDLQFGDHIIHWVTYVELCAPCEIKYSVVGHHETLEADAPYILKEAGIDHLVSYPTIPPGITMYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN", "length": 356 }, "evidence": [ { "id": "F6PRF2", "url": "https://omabrowser.org/oma/group/F6PRF2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "F6PRF2", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate biosynthetic process", "id": "GO:0016051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016051", "evidence": [ { "database": "UniProtKB", "id": "F6PRF2", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ], "pmid": "" }, { "name": "proteoglycan biosynthetic process", "id": "GO:0030166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030166", "evidence": [ { "database": "UniProtKB", "id": "F6PRF2", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F6PRF2", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-6786048", "name": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-6786371" ], "output_participant_list": [ "R-ALL-6786380" ], "enzyme_list": [ "F6PRF2-1" ], "evidence": [ { "id": "R-BTA-6786048", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6786048" } ] }, { "id": "R-BTA-9940718", "name": "CHST10 sulfates matriglycan chain", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen", "input_participant_list": [ "R-BTA-9940706" ], "output_participant_list": [ "R-BTA-9940731" ], "enzyme_list": [ "F6PRF2-1" ], "evidence": [ { "id": "R-BTA-9940718", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940718" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6786371", "participant_name": "HNK1 carbohydrate [Golgi lumen]", "crossref": [ { "id": "747405", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-6786380", "participant_name": "S-HNK1 carbohydrate [Golgi lumen]", "crossref": [ { "id": "86335", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-BTA-9940706", "participant_name": "DAG1 [Golgi lumen]", "crossref": [ { "id": "A0A3Q1MDA4", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000011580", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000068898", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000078428", "database": "ENSEMBL", "url": "" }, { "id": "27871", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9940731", "participant_name": "DAG1 [Golgi lumen]", "crossref": [ { "id": "27871", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000068898", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1MDA4", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000011580", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000078428", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F6PRF2", "gene_name": "CHST10", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "F6PRF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PRF2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6PRF2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 552, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6PRF2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6PRF2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G01954ZH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G06898ZN", "type": "O-linked", "subtype": "O-mannose core M1" }, { "glytoucan_ac": "G16475ZM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17406OI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18129IO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25614IV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30265AO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G43848AQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G53366RQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G55005SM", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G57941GW", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G60606QD", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G73224TY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79253EJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G87632FZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G89932GS", "type": "N-linked", "subtype": "Hybrid" } ], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 512, "end_pos": 514 } ] }, "class_list": [ "glycan-modifying enzyme", "glycogene" ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N287-1", "uniprot_ac": "F1N287", "uniprot_id": "F1N287_BOVIN", "mass": { "chemical_mass": 66249.0, "monoisotopic_mass": 66249.0 }, "refseq": { "ac": "NP_001421774", "name": "T-box transcription factor TBX15 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421774" }, "gene_names": [ { "name": "TBX15", "type": "recommended", "evidence": [ { "id": "F1N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ] }, { "name": "TBX15", "type": "synonym", "evidence": [ { "id": "NP_001421774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421774" } ] } ], "protein_names": [ { "name": "T-box 15", "type": "synonym", "evidence": [ { "id": "NP_001421774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421774" } ] }, { "name": "T-box transcription factor 15", "type": "synonym", "evidence": [ { "id": "F1N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N287/entry#names_and_taxonomy" } ] }, { "name": "T-box transcription factor TBX15 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421774" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBX15", "url": "https://www.uniprot.org/uniprotkb/F1N287", "locus": { "chromosome": "3", "start_pos": 24254398, "end_pos": 24130576, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007767", "url": "https://www.ensembl.org/id/ENSBTAG00000007767" } ] } } ], "crossref": [ { "id": "F1N287", "url": "https://alphafold.ebi.ac.uk/entry/F1N287", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007767", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007767", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20198", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20198", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521974", "url": "https://www.ncbi.nlm.nih.gov/gene/521974", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QTANTCD", "url": "https://omabrowser.org/oma/group/QTANTCD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPT3", "url": "https://www.orthodb.org/?gene=E1BPT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11267:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11267:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421774", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2M1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2M1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2M1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPT3", "url": "https://www.uniprot.org/uniprotkb/E1BPT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPT3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N287-1", "url": "https://www.uniprot.org/uniprotkb/F1N287-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAAKMSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDAEDAGAHGLEPHPDSEQSTGSDSEVLTERTSCSFDTHADLGPGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSAAQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHGMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 607, "header": "tr|F1N287-1|F1N287_BOVIN Isoform 1 of T-box transcription factor 15 OS=Bos taurus OX=9913 GN=TBX15 PE=4 SV=4 CANONICAL=F1N287-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEZ2/entry", "sequence": { "sequence": "MPAFYLVALNPTFLFASALPSTHTLETNQDSEQSTGSDSEVLTERTSCSFDTHADLGPGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSAAQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHGMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 563, "header": "tr|A0AAA9SEZ2-1|F1N287_BOVIN Computationally mapped isoform of T-box transcription factor 15 OS=Bos taurus OX=9913 GN=TBX15 PE=4 SV=1 CANONICAL=F1N287-1" }, "locus": { "chromosome": "3", "start_pos": 24253394, "end_pos": 24203522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119582.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119582.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083959.1" } ] } }, { "isoform_ac": "A0AAA9SKH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH4/entry", "sequence": { "sequence": "MSSSTFLYLEEINISFCLVQDSEQSTGSDSEVLTERTSCSFDTHADLGPGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSAAQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHGMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 554, "header": "tr|A0AAA9SKH4-1|F1N287_BOVIN Computationally mapped isoform of T-box transcription factor 15 OS=Bos taurus OX=9913 GN=TBX15 PE=4 SV=1 CANONICAL=F1N287-1" }, "locus": { "chromosome": "3", "start_pos": 24253394, "end_pos": 24202662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128660.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128660.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083115.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083115.1" } ] } }, { "isoform_ac": "A0ABI0P2M1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2M1/entry", "sequence": { "sequence": "MSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSAAQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHGMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 496, "header": "tr|A0ABI0P2M1-1|A0ABI0P2M1_BOVIN Computationally mapped isoform of T-box transcription factor 15 OS=Bos taurus OX=9913 GN=TBX15 PE=4 SV=1 CANONICAL=F1N287-1" }, "locus": { "chromosome": "3", "start_pos": 24253394, "end_pos": 24204476, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150725.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150725.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105115.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105115.1" } ] } }, { "isoform_ac": "E1BPT3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPT3/entry", "sequence": { "sequence": "MLHQESEQDSEQSTGSDSEVLTERTSCSFDTHADLGPGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSAAQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHGMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 542, "header": "tr|E1BPT3-1|E1BPT3_BOVIN Computationally mapped isoform of T-box transcription factor 15 OS=Bos taurus OX=9913 GN=TBX15 PE=4 SV=4 CANONICAL=F1N287-1" }, "locus": { "chromosome": "3", "start_pos": 24253394, "end_pos": 24178016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010213.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010213.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010213.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010213.6" } ] } }, { "isoform_ac": "F1N287-1", "url": "https://www.uniprot.org/uniprotkb/F1N287/entry", "sequence": { "sequence": "MRAAKMSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDAEDAGAHGLEPHPDSEQSTGSDSEVLTERTSCSFDTHADLGPGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSAAQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHGMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 607, "header": "tr|F1N287-1|F1N287_BOVIN Isoform 1 of T-box transcription factor 15 OS=Bos taurus OX=9913 GN=TBX15 PE=4 SV=4 CANONICAL=F1N287-1" }, "locus": { "chromosome": "3", "start_pos": 24253394, "end_pos": 24130846, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033724.7", "url": "https://www.ensembl.org/id/ENSBTAT00000033724.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033633.6", "url": "https://www.ensembl.org/id/ENSBTAP00000033633.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 361, "start_aa": "Thr", "end_pos": 361, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr361", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZJ07-1", "protein_name": "T-box transcription factor 15", "gene_name": "Tbx15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPTGPLGDTDDPATHGLEPHPDSEQSTGSDSEVLTERTSCSFSAHTDLASGAAGSVPVAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPSTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTASATQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHSVHMISPSTNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 602 }, "evidence": [ { "id": "F1N287", "url": "https://omabrowser.org/oma/group/F1N287/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NA14-1", "protein_name": "T-box transcription factor 15", "gene_name": "TBX15", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSERRRSAVALSSRAHAFSVEALIGTNKKRKLRDWEDKGLDLSMESLSPNGQLGDGEDPTQCLDLNPDSEQSTGSDTEVLAERTSCSFGSHSDLTSGGSGPQPPPPSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPSGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPAFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLGDSGYNRLQSGTASASQPSESFMPQRTPSLISGMPTPSSLPSNSKMEAYSSQLGSFPSSQFQYVMQAGNPASSSSSSHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPASPRLAASPEKLTTSQSTLLCSSPSSGAFGERQYLSTGMDHGMHMISPPSSNQQTANACDNRQYGAVQGSSSQMSVHMV", "length": 601 }, "evidence": [ { "id": "F1N287", "url": "https://omabrowser.org/oma/group/F1N287/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O70306-1", "protein_name": "T-box transcription factor TBX15", "gene_name": "Tbx15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDTDDPATHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTASATQPSETFMPQRTPSLISGIPTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHSMHMISPSTNNQQATNTCDGRQYGAVPGSASQMSVHMV", "length": 602 }, "evidence": [ { "id": "F1N287", "url": "https://omabrowser.org/oma/group/F1N287/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96SF7-1", "protein_name": "T-box transcription factor TBX15", "gene_name": "TBX15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDTEDAAAHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSATQPSETFMPQRTPSLISGIPTPPSLPGNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPSGMEHSMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV", "length": 602 }, "evidence": [ { "id": "F1N287", "url": "https://omabrowser.org/oma/group/F1N287/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "RNA polymerase II transcription repressor complex", "id": "GO:0090571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090571", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "cell fate specification", "id": "GO:0001708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001708", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N287", "url": "https://www.uniprot.org/uniprotkb/F1N287" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N287-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 607, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N287-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N287" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N287" }, { "id": "PS50252", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50252" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "T-box", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 309, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 361 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 313, "end_pos": 315 }, { "start_pos": 400, "end_pos": 402 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N391-1", "uniprot_ac": "F1N391", "uniprot_id": "F1N391_BOVIN", "mass": { "chemical_mass": 93930.0, "monoisotopic_mass": 93930.0 }, "refseq": {}, "gene_names": [ { "name": "TMC7", "type": "recommended", "evidence": [ { "id": "F1N391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N391" } ] } ], "protein_names": [ { "name": "Transmembrane channel-like protein", "type": "recommended", "evidence": [ { "id": "F1N391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N391/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N391", "url": "https://www.uniprot.org/uniprotkb/F1N391" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMC7", "url": "https://www.uniprot.org/uniprotkb/F1N391", "locus": { "chromosome": "25", "start_pos": 16930192, "end_pos": 16990049, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016505", "url": "https://www.ensembl.org/id/ENSBTAG00000016505" } ] } } ], "crossref": [ { "id": "F1N391", "url": "https://alphafold.ebi.ac.uk/entry/F1N391", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016505", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016505", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR012496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N391", "url": "https://www.orthodb.org/?gene=F1N391", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23302", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23302", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23302:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23302:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N391", "url": "https://www.uniprot.org/uniprotkb/F1N391", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N391-1", "url": "https://www.uniprot.org/uniprotkb/F1N391-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVPGSSGSPPASPIPGPGRRAAAPSVGSWPVPRDPARRGSGGPARRAWEGRRRPAPASMTSAPEPGIPAPGGKAGRRRQLPERVSGGLSGAWGAVMSESSISALPPGRPSRQPFIHQESLSLDSSCFSSPPVNFLQELPSYRSIARKRTTILSRDKQSGTLLKPTDSYNFQLEGELTEDLDSQSIRKYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFIEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMVVLLPVLLTRYKITNSSFILIPSQDVDIQCTVYPISSSGLIYFYSYVIDLLSGTGFLEDTYLFYGHYTIDGVKFQNFTYDLPLAYLLSTIAYLALSLVWIVKRSVEGFKINLIRSEEHFQSYCNKVFAGWDFCITNRSMADLKHSSLRYELRADLEEERIRQKIAERTSEETIRIYSLRLFLNCIVLAVLAACFYAIYKATIFSQEHMKKEIDKMVFGENLLILYLPSIVITLANFITPIIFAKIIHYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDNYLCELCGYNQKLYPCWETQVGQEMYKLMIFDLIIILAVTLFVDFPRKILVTYCSSWKLFQCWGEQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEISLLYTCRPSPRQFRASNSNFFFLLVLLIGLCLAIIPLTISMARIPSSKACGPFTNFNTTWEVVPKTVSTFPNSLQTLVYGITSEAFAVPFFMIICLIMFYFIALAGAHKRVVVQLREQLNLESRDKRYLIQKLTEAQRDLRNRLD", "length": 823, "header": "tr|F1N391-1|F1N391_BOVIN Isoform 1 of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC7 PE=3 SV=3 CANONICAL=F1N391-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG95/entry", "sequence": { "sequence": "MEPVPGSSGSPPASPIPGPGRRAAAPSVGSWPVPRDPARRGSGGPARRAWEGRRRPAPASMTSAPEPGIPAPGGKAGRRRQLPERVSGGLSGAWGAVMSESSISALPPGRPSRQPFIHQESLSLDSSCFSSPPVNFLQELPSYRSIARKRTTILSRDKQSGTLLKPTDSYNFQLEGELTEDLDSQSIRKYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFIEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMVVLLPVLLTRYKITNSSFILIPSQDVDIQCTVYPISSSGLIYFYSYVIDLLSGTGFLEDTYLFYGHYTIDGVKFQNFTYDLPLAYLLSTIAYLALSLVWIVKRSVEGFKINLIRSEEHFQSYCNKVFAGWDFCITNRSMADLKHSSLRYELRADLEEERIRQKIAERTSEETIRIYSLRLFLNCIVLAVLAACFYAIYKATIFSQEHMKKEIDKMVFGENLLILYLPSIVITLANFITPIIFAKIIHYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDNYLCELCGYNQKLYPCWETQVGQEMYKLMIFDLIIILAVTLFVDFPRKILVTYCSSWKLFQCWGEQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEHPVLQSLRAIHQLQHHLGSGPQDSEHLPQLAADAGLWHHFGSLRSAFFHDHLPHYVLLHRPGRSAQAGGRPAPRAAEPGKS", "length": 758, "header": "tr|A0AAA9SG95-1|F1N391_BOVIN Computationally mapped isoform of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC7 PE=3 SV=1 CANONICAL=F1N391-1" }, "locus": { "chromosome": "25", "start_pos": 16990024, "end_pos": 16931260, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114258.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114258.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082895.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082895.1" } ] } }, { "isoform_ac": "F1N391-1", "url": "https://www.uniprot.org/uniprotkb/F1N391/entry", "sequence": { "sequence": "MEPVPGSSGSPPASPIPGPGRRAAAPSVGSWPVPRDPARRGSGGPARRAWEGRRRPAPASMTSAPEPGIPAPGGKAGRRRQLPERVSGGLSGAWGAVMSESSISALPPGRPSRQPFIHQESLSLDSSCFSSPPVNFLQELPSYRSIARKRTTILSRDKQSGTLLKPTDSYNFQLEGELTEDLDSQSIRKYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFIEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMVVLLPVLLTRYKITNSSFILIPSQDVDIQCTVYPISSSGLIYFYSYVIDLLSGTGFLEDTYLFYGHYTIDGVKFQNFTYDLPLAYLLSTIAYLALSLVWIVKRSVEGFKINLIRSEEHFQSYCNKVFAGWDFCITNRSMADLKHSSLRYELRADLEEERIRQKIAERTSEETIRIYSLRLFLNCIVLAVLAACFYAIYKATIFSQEHMKKEIDKMVFGENLLILYLPSIVITLANFITPIIFAKIIHYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDNYLCELCGYNQKLYPCWETQVGQEMYKLMIFDLIIILAVTLFVDFPRKILVTYCSSWKLFQCWGEQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEISLLYTCRPSPRQFRASNSNFFFLLVLLIGLCLAIIPLTISMARIPSSKACGPFTNFNTTWEVVPKTVSTFPNSLQTLVYGITSEAFAVPFFMIICLIMFYFIALAGAHKRVVVQLREQLNLESRDKRYLIQKLTEAQRDLRNRLD", "length": 823, "header": "tr|F1N391-1|F1N391_BOVIN Isoform 1 of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC7 PE=3 SV=3 CANONICAL=F1N391-1" }, "locus": { "chromosome": "25", "start_pos": 16990024, "end_pos": 16931196, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021939.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021939.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021939.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021939.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N391", "url": "https://www.uniprot.org/uniprotkb/F1N391" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sensory perception of mechanical stimulus", "id": "GO:0050954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050954", "evidence": [ { "database": "UniProtKB", "id": "F1N391", "url": "https://www.uniprot.org/uniprotkb/F1N391" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ion channel inhibitor activity", "id": "GO:0008200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008200", "evidence": [ { "database": "UniProtKB", "id": "F1N391", "url": "https://www.uniprot.org/uniprotkb/F1N391" } ], "pmid": "" }, { "name": "mechanosensitive monoatomic ion channel activity", "id": "GO:0008381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008381", "evidence": [ { "database": "UniProtKB", "id": "F1N391", "url": "https://www.uniprot.org/uniprotkb/F1N391" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 735, "end_pos": 737, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N391-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 823, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N391-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N391" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N391" }, { "id": "PF07810", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07810" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TMC", "eco_id": "ECO_0000259", "start_pos": 583, "end_pos": 694, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 735, "end_pos": 737 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4G1-1", "uniprot_ac": "F2Z4G1", "uniprot_id": "F2Z4G1_BOVIN", "mass": { "chemical_mass": 38897.0, "monoisotopic_mass": 38897.0 }, "refseq": {}, "gene_names": [ { "name": "MEF2B", "type": "recommended", "evidence": [ { "id": "F2Z4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ] } ], "protein_names": [ { "name": "Myocyte enhancer factor 2B", "type": "synonym", "evidence": [ { "id": "F2Z4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEF2B", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1", "locus": { "chromosome": "7", "start_pos": 4099712, "end_pos": 4095640, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001818", "url": "https://www.ensembl.org/id/ENSBTAG00000001818" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001818", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001818", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "APWQHSR", "url": "https://omabrowser.org/oma/group/APWQHSR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11945:SF383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11945:SF383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00319", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00319", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-525793", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SHH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4G1-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGVGLDGPELEPDEGLEGPGEKLRRLAGDGGDPALPRPRLYPAAPTMPSPDMVYGALPPPACEPTGLGEALPAQSRPSPFRPAAPKAGPPGLAHPLFSPSHLASKTPPPLYLAADGRRPDLPGGLAGTRGGLSSSRGLYGGLQSPCSTAAPGPPLGSFPFLPAGPPEYGLGDPPPPPGLLQPPTLAPWQPSRADGPPATPTQPSGGRSLGEDGPPARGASSPTPPVSIKSERLSPAPGGPGDFPKTFPYPLLLARPLAEPLRPGPPLRRLPTADGWPR", "length": 368, "header": "tr|F2Z4G1-1|F2Z4G1_BOVIN Isoform 1 of Myocyte enhancer factor 2B OS=Bos taurus OX=9913 GN=MEF2B PE=4 SV=1 CANONICAL=F2Z4G1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH2/entry", "sequence": { "sequence": "MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGVGLDGPELEPDEGLEGPGEKLRRLAGDGGDPALPRPRLYPAAPTMPSPDMVYGALPPPACEPTGLGEALPAQSRPSPFRPAAPKAGPPERTLRWPAESLLHRCPRTPARELPLPPCRPPSGGRSLGEDGPPARGASSPTPPVSIKSERLSPAPGGPGDFPKTFPYPLLLARPLAEPLRPGPPLRRLPTADGWPR", "length": 286, "header": "tr|A0AAA9SHH2-1|F2Z4G1_BOVIN Computationally mapped isoform of Myocyte enhancer factor 2B OS=Bos taurus OX=9913 GN=MEF2B PE=4 SV=1 CANONICAL=F2Z4G1-1" }, "locus": { "chromosome": "7", "start_pos": 4099488, "end_pos": 4095668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129177.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129177.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083362.1" } ] } }, { "isoform_ac": "F2Z4G1-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1/entry", "sequence": { "sequence": "MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGVGLDGPELEPDEGLEGPGEKLRRLAGDGGDPALPRPRLYPAAPTMPSPDMVYGALPPPACEPTGLGEALPAQSRPSPFRPAAPKAGPPGLAHPLFSPSHLASKTPPPLYLAADGRRPDLPGGLAGTRGGLSSSRGLYGGLQSPCSTAAPGPPLGSFPFLPAGPPEYGLGDPPPPPGLLQPPTLAPWQPSRADGPPATPTQPSGGRSLGEDGPPARGASSPTPPVSIKSERLSPAPGGPGDFPKTFPYPLLLARPLAEPLRPGPPLRRLPTADGWPR", "length": 368, "header": "tr|F2Z4G1-1|F2Z4G1_BOVIN Isoform 1 of Myocyte enhancer factor 2B OS=Bos taurus OX=9913 GN=MEF2B PE=4 SV=1 CANONICAL=F2Z4G1-1" }, "locus": { "chromosome": "7", "start_pos": 4099488, "end_pos": 4095668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002377.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002377.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002377.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002377.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 289, "start_aa": "Thr", "end_pos": 289, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr289", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 313, "start_aa": "Thr", "end_pos": 313, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr313", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-525793", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-525793", "resource": "Reactome", "description": "Myogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "F7EZT3-1", "protein_name": "Myocyte enhancer factor 2B", "gene_name": "Mef2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIALIIFNSAQRLFQYASSDMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDMEEGPEGPGEKLLRTLGGDRGLVSPPPRIYPVAPAMSVSELSYRVPPATSGCDPGGLGEAPSVHSRSPHFRPPGLGHPIFSPSHLAGKTPPPLYLATDGRRPDLPPGLVGARGGLGTSRSLYSGLQSPGAPGPALGSFAFLPPGSADCSPGDAAQVPLQPSPWPPTRDAVDPAGPAARSLCEEGPPSREASPPTPPVSIKSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPASLRRLTPDSWPR", "length": 348 }, "evidence": [ { "id": "F2Z4G1", "url": "https://omabrowser.org/oma/group/F2Z4G1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O55087-1", "protein_name": "Myocyte-specific enhancer factor 2B", "gene_name": "Mef2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIALIIFNSAQRLFQYASSDMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDMEEGPEGPGEKLLRTLGGDRGSASPRPRIYPVAPAMSVSELSYRVPPATPGCDPGGLGEVPSVHSRPAYFRPPGLGHPIFSPSHLASKTPPPLYLATDGRRPDLPPGLVGARGGLGTSRSLYSGLQSPGAPGPALGSFAFLPSGSTDCSPGDAAQGPLQPSPWPPTRDAVDPARPVARSLCKEGPPSRGASPPTPPVSIKSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPSASLHRLTPDSWPR", "length": 349 }, "evidence": [ { "id": "F2Z4G1", "url": "https://omabrowser.org/oma/group/F2Z4G1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q02080-1", "protein_name": "Myocyte-specific enhancer factor 2B", "gene_name": "MEF2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPVGAEAWARRVPQPAAPPRRPPQSASSLSASLRPPGAPATFLRPSPIPCSSPGPWQSLCGLGPPCAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASSEKTQQ", "length": 365 }, "evidence": [ { "id": "F2Z4G1", "url": "https://omabrowser.org/oma/group/F2Z4G1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F2Z4G1", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F2Z4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4G1" }, { "id": "PS50066", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50066" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MADS-box", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 61, "start_aa": "Met", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 289, 313 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3I4-1", "uniprot_ac": "F1N3I4", "uniprot_id": "F1N3I4_BOVIN", "mass": { "chemical_mass": 232725.0, "monoisotopic_mass": 232725.0 }, "refseq": {}, "gene_names": [ { "name": "MYOF", "type": "recommended", "evidence": [ { "id": "F1N3I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ] } ], "protein_names": [ { "name": "Myoferlin", "type": "recommended", "evidence": [ { "id": "F1N3I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I4/entry#names_and_taxonomy" } ] }, { "name": "Fer-1-like protein 3", "type": "synonym", "evidence": [ { "id": "F1N3I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR.", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4#function" }, { "database": "UniProtKB", "id": "ARBA00057975", "url": "https://www.uniprot.org/uniprotkb/ARBA00057975#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYOF", "url": "https://www.uniprot.org/uniprotkb/F1N3I4", "locus": { "chromosome": "26", "start_pos": 14623106, "end_pos": 14803246, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016918", "url": "https://www.ensembl.org/id/ENSBTAG00000016918" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04011", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04011", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04017", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04017", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04018", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04018", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04037", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04037", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08373", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08373", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TCLEFRV", "url": "https://omabrowser.org/oma/group/TCLEFRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3I4", "url": "https://www.orthodb.org/?gene=F1N3I4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12546", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12546", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12546:SF55", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12546:SF55", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45911:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45911:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08150", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08150", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08151", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08151", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16165", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16165", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3I4-1", "url": "https://www.uniprot.org/uniprotkb/F1N3I4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLEIVVKDFETIGQNKLIGTATIALKDLMGDQSRSLPYKLVSLLNERGQETGATIDLVIGYHPPSAPHPNDPGGTSVPGTGEEEEDGGDEDMLDSTVRGPGPRGPGGTVPEAHLARRLTKVKSSRRMLSNKPQDFQIRVRVIEGRQLSGNNIKPVVKVHICGQTHRTRIKRGNNPFFDELFFYNVHLTPSELMDEIISIRVYNSHSLRADSLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGAKGYLKVSMFVLGTGDEPPPEKQDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGVADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGSGAASYTANTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNSGKGEGVAYRGRILVELSTLLEKTPPDKKLESISHDDLLVVEKYQRRRKYSLSAVFHSATMLQDIGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLVMAERLQSNIEALKAGIQGKIPSNELAKMWHKLMDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRALSQIHEAAVRMRSEVPDVKSTLVEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGGDASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGDWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGEWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWVYDINRAVDERGWEYGITIPPDNKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQSTSSTARAMAEFEDREGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTDDGEEKSAEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYIYQARNLMALDKDSFSDPYAHVSFLHRSKTTEIIHSTLNPTWDQTIIFDEIEIYGEPQTILQNPPKVIIELFDNDQVGKDEFLGRSMCSPLVKLDSEMDITPKLLWYPVMNGDKTCGDVLVTAELILRHKDGSNLPILPSQRAPNLYMVPQGIRPVVQLTAIEAASCSLWGPEPMPNGQREPEMVPLVGREVTPTSVTHLPPQFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIDRLDRFRCDPYAGKEDIVPQLKASFLSTPPRRDIVIEIEDTKPLLASKEEEIVDWWSKFYASTGEHEKCGQYIQKGYSKLKIYDCELEDVEEFEGLTDFSDTFKLFRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDNYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEQYCVSGVNTWRDQLKPTQLLQNVARFKGFPPPVLSEDGSSIRYGGKDYGLDEFGKHTANKILHQHLGPPEERLALYILRTQGLVPEHVETRTLHSSFQPNISQGRLQMWVDVFPKNLGPPGPPFNITPRKAKKYYLRVIIWNTKDVVLDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGVGNFNWRFVFPFDYLPAEQLCLVAKKEHFWSIDQTEFRVPPRLVIQIWDNDKFSLDDYLGFLELDLHHTIIPAKSPEKCSLNMIPDLKAMNPLKVKTASLFEQKSMKGWWPCYTEKDGSRVMAGKVEMTLEVLNEKEADERPAGKGRDEPNMNPKLDPPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIALLILLILLFFVAVFLYSLPNYLSMKIVKPNA", "length": 2045, "header": "tr|F1N3I4-1|F1N3I4_BOVIN Isoform 1 of Myoferlin OS=Bos taurus OX=9913 GN=MYOF PE=1 SV=3 CANONICAL=F1N3I4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI21/entry", "sequence": { "sequence": "MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLEIVVKDFETIGQNKLIGTATIALKDLMGDQSRSLPYKLVSLLNERGQETGATIDLVIGYHPPSAPHPNDPGGTSVPGTGGKLTLLKAQPMPLGGIY", "length": 161, "header": "tr|A0AAA9SI21-1|F1N3I4_BOVIN Computationally mapped isoform of Myoferlin OS=Bos taurus OX=9913 GN=MYOF PE=1 SV=1 CANONICAL=F1N3I4-1" }, "locus": { "chromosome": "26", "start_pos": 14803157, "end_pos": 14748486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121730.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121730.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083392.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083392.1" } ] } }, { "isoform_ac": "F1N3I4-1", "url": "https://www.uniprot.org/uniprotkb/F1N3I4/entry", "sequence": { "sequence": "MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLEIVVKDFETIGQNKLIGTATIALKDLMGDQSRSLPYKLVSLLNERGQETGATIDLVIGYHPPSAPHPNDPGGTSVPGTGEEEEDGGDEDMLDSTVRGPGPRGPGGTVPEAHLARRLTKVKSSRRMLSNKPQDFQIRVRVIEGRQLSGNNIKPVVKVHICGQTHRTRIKRGNNPFFDELFFYNVHLTPSELMDEIISIRVYNSHSLRADSLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGAKGYLKVSMFVLGTGDEPPPEKQDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGVADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGSGAASYTANTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNSGKGEGVAYRGRILVELSTLLEKTPPDKKLESISHDDLLVVEKYQRRRKYSLSAVFHSATMLQDIGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLVMAERLQSNIEALKAGIQGKIPSNELAKMWHKLMDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRALSQIHEAAVRMRSEVPDVKSTLVEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGGDASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGDWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGEWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWVYDINRAVDERGWEYGITIPPDNKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQSTSSTARAMAEFEDREGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTDDGEEKSAEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYIYQARNLMALDKDSFSDPYAHVSFLHRSKTTEIIHSTLNPTWDQTIIFDEIEIYGEPQTILQNPPKVIIELFDNDQVGKDEFLGRSMCSPLVKLDSEMDITPKLLWYPVMNGDKTCGDVLVTAELILRHKDGSNLPILPSQRAPNLYMVPQGIRPVVQLTAIEAASCSLWGPEPMPNGQREPEMVPLVGREVTPTSVTHLPPQFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIDRLDRFRCDPYAGKEDIVPQLKASFLSTPPRRDIVIEIEDTKPLLASKEEEIVDWWSKFYASTGEHEKCGQYIQKGYSKLKIYDCELEDVEEFEGLTDFSDTFKLFRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDNYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEQYCVSGVNTWRDQLKPTQLLQNVARFKGFPPPVLSEDGSSIRYGGKDYGLDEFGKHTANKILHQHLGPPEERLALYILRTQGLVPEHVETRTLHSSFQPNISQGRLQMWVDVFPKNLGPPGPPFNITPRKAKKYYLRVIIWNTKDVVLDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGVGNFNWRFVFPFDYLPAEQLCLVAKKEHFWSIDQTEFRVPPRLVIQIWDNDKFSLDDYLGFLELDLHHTIIPAKSPEKCSLNMIPDLKAMNPLKVKTASLFEQKSMKGWWPCYTEKDGSRVMAGKVEMTLEVLNEKEADERPAGKGRDEPNMNPKLDPPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIALLILLILLFFVAVFLYSLPNYLSMKIVKPNA", "length": 2045, "header": "tr|F1N3I4-1|F1N3I4_BOVIN Isoform 1 of Myoferlin OS=Bos taurus OX=9913 GN=MYOF PE=1 SV=3 CANONICAL=F1N3I4-1" }, "locus": { "chromosome": "26", "start_pos": 14803157, "end_pos": 14623783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038965.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038965.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038769.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038769.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LPZ8-1", "protein_name": "Myoferlin", "gene_name": "Myof", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRVIVESATNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDSSSSLVIVVKDFETIGQNKLIGTATVSLKDLIGDQNRSLPYKQISLLNEKGQDTGATIDLVIGYTPPSAPYPNDPSGTSVTGVGEEEEEDQGDEDRVDGMVRGPGPKGPSGTMSEAQLARRITKGKSSRRMLSNKPQDFQIRVRVIEGRQLCGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVHITPSELMDEIISIRVYNSHSLRADSLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGAKGYMKVSMFVLGTGDEPPSEKRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIERNANPEWNQVVNLQIKFPSMCEKIKLTVYDWDRLTKNDVVGTTYLYLSKIAASGGEVEDFSSSGTGAASYTANTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNSGKGEGVAYRGRILVELNTFLEKKPPEKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDATCKPLASTTQYSRAVFDGNYYYYLPWARTKPVVTLTSYWEDISHRLDAVNTLLVMAERLQSNIEAVKSGIQGKIPTNQLAELWLKLIDEVIEDTRYTLPVTEGKANVTVLDTQIRKLRLRFLSQIHEAALRMRSEATDVKSTLLEIEEWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGGNASGKYCGKTQTILLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALVFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGDWVVDPERSLLTEADAGHTEFTDEVYQNETRYPGGEWKQAEDTYTDANGDKAASPNEMTCPPGWEWEDDAWTYDINRAVDEKGWEYGITIPPDNKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELEDREGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYIYQARNLMALDKDSFSDPYAHVSFLHRSKTTEIIHSTLNPTWDQTIIFDDVEIFGEPQTVLQNPPKVIIELFDSDQVGKDEFLGRSICSPLVKLNSETDTTPKLLWHPVMNGDKACGDVLVTAELILRNKDGSNLPILPSQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNYQMASITSPSLVVECGGERVESVVIKSLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIDHLDRFRCDPYAGKEDIVPQLKASLMSAPPCRDVIIEIEDTKPLLASKCLSSMSTALSKMASPRTVHLSEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYDCELEDVADFEGLTDFSDTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVQGLQLQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTINPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETTIDLENRFLSRFGSHCGIPEQYCVSGVNTWRDQLRPTQLLQNVARFKGFPPPVLSEDGSRIQYGGRDYHLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKTYYLRVIIWNTRDVILDEKSITGEDMSDIYVKGWISGSEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRVPPRLIIQIWDNDKFSLDDYLGFLELDLHRTIIPAKTSEKCSLDMIPDLKAMDPLKAKTASLFEQKSMKGWWPCYADKDGSRVMAGKVEMTLEVLNEREADERPAGKGRSEPNMNPKLDPPNRPETSFLWFTNPCKTMRFIVWRRFKWVIIGLLLLLILLLFVAVLLYSLPNYLSMKIVRPNA", "length": 2080 }, "evidence": [ { "id": "F1N3I4", "url": "https://omabrowser.org/oma/group/F1N3I4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q69ZN7-1", "protein_name": "Myoferlin", "gene_name": "Myof", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRVIVESATNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDSSSSLVIVVKDFETIGQNKLIGTATVSLKDLIGDQNRSLPYKQTSLLNEKGQDTGATIDLVIGYTPPSAPHPNDPSGTSVPGMGEEEEEDQGDEDRVDGIVRGPGPKGPSGTVSEAQLARRITKGKSSRRMLSNKPQDFQIRVRVIEGRQLCGNNIRPVVKVHICGQTHRTRIKRGNNPFFDELFFYNVHITPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGAKGYMKVSMFVLGTGDEPPPEKRDRDNDSDDVESNLLLPAGIALRWVTFMLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIERNANPEWNQVVNLQIKFPSMCEKIKLTVYDWDRLTKNDVVGTTYLYLSKIAASGGEVEATTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNSGKGEGVAYRGRIFVELNTFLEKKPPEKKLEPISSDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDATCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLVMAERLQSNIEAVKSGIQGKIPANQLAEVWLKLIDEVIEDTRYTLPVTEGKANVTVLDTQIRKLRSRFLSQIHEAALRMRSEATDVKSTLLEIEEWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGGNASGKYCGKTQTILLKYPQEKTNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALVFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGDWVVDPERSLLTEADAGHTEFTDEVYQNENRYPGGEWKQAEDTYTDANGDKAASPSEMTCPPGWEWEDDAWIYDINRAVDEKGWEYGITIPPDNKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELEDREGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGEEKGPEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYIYQARNLMALDKDSFSDPYAHVSFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIFGEPQTVLQNPPNVTIELFDNDQVGKDEFLGRSICSPLVKLNSETDITPKLLWHPVMNGDKACGDVLVTAELILRNKDGSNLPILPSQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNYQMASVTSPSLVVECGGERVESVVIKSLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIDHLDRFRCDPYAGKEDIVPQLKASLMSAPPCREVVIEIEDTKPLLASKLSEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYDCELEDVADFEGLTDFSDTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVQGLQLQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETTIDLENRFLSRFGSHCGIPEQYCVSGVNTWRDQLRPTQLLQNVARFKGFPPPVLSEDGSRIRYGGRDYHLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEDMSDIYVKGWISGSEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRVPPRLIIQIWDNDKFSLDDYLGFLELDLHRTIIPAKTSEKCSLDMIPDLKAMDPLKAKTASLFEQRSMKGWWPCYADKDGTRVMAGKVEMTLEVLNEREADERPAGKGRSEPNMNPKLDPPNRPETSFLWFTNPCKTMRFIVWRRFKWVIIGLLLLLILLLFVAVLLYSLPNYLSMKIVRPNA", "length": 2048 }, "evidence": [ { "id": "F1N3I4", "url": "https://omabrowser.org/oma/group/F1N3I4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZM1-1", "protein_name": "Myoferlin", "gene_name": "MYOF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDLVIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKPNV", "length": 2061 }, "evidence": [ { "id": "F1N3I4", "url": "https://omabrowser.org/oma/group/F1N3I4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "plasma membrane repair", "id": "GO:0001778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001778", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" }, { "name": "membrane fusion", "id": "GO:0061025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061025", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" }, { "name": "T-tubule organization", "id": "GO:0033292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033292", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "F1N3I4", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1738, "end_pos": 1740, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1763, "end_pos": 1765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 713, "end_pos": 715, "annotation": "n_glycosylation_sequon" }, { "start_pos": 936, "end_pos": 938, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I4" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 101, "start_aa": "Met", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1738, "end_pos": 1740 }, { "start_pos": 1763, "end_pos": 1765 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 713, "end_pos": 715 }, { "start_pos": 936, "end_pos": 938 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N214-1", "uniprot_ac": "F1N214", "uniprot_id": "F1N214_BOVIN", "mass": { "chemical_mass": 86101.0, "monoisotopic_mass": 86101.0 }, "refseq": {}, "gene_names": [ { "name": "ENAH", "type": "recommended", "evidence": [ { "id": "F1N214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ] } ], "protein_names": [ { "name": "Protein enabled homolog", "type": "recommended", "evidence": [ { "id": "F1N214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N214/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY87#function" }, { "database": "UniProtKB", "id": "ARBA00056269", "url": "https://www.uniprot.org/uniprotkb/ARBA00056269#function" }, { "database": "UniProtKB", "id": "A0AAA9SJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ25#function" }, { "database": "UniProtKB", "id": "A0AAA9TVH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH4#function" }, { "database": "UniProtKB", "id": "A0AAA9U218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U218#function" }, { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ENAH", "url": "https://www.uniprot.org/uniprotkb/F1N214", "locus": { "chromosome": "16", "start_pos": 28534629, "end_pos": 28690024, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016185", "url": "https://www.ensembl.org/id/ENSBTAG00000016185" } ] } } ], "crossref": [ { "id": "F1N214", "url": "https://alphafold.ebi.ac.uk/entry/F1N214", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016185", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016185", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01207", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01207", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22185", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22185", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513095", "url": "https://www.ncbi.nlm.nih.gov/gene/513095", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F1N214", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1N214*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000697", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "XDILDEM", "url": "https://omabrowser.org/oma/group/XDILDEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY87", "url": "https://www.orthodb.org/?gene=A0A3Q1LY87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N214", "url": "https://www.orthodb.org/?gene=F1N214", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11202:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11202:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46563", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46563", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46563:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46563:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00568", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00568", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08776", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08776", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LY87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY87-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U218", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U218-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U218-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N214-1", "url": "https://www.uniprot.org/uniprotkb/F1N214-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAAPSSDSSLYSAPLPEYASCQPPSAPPPSYAKVISAPVSEATPEYAVVTALPPTSTPPTPPLRHPATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSPQPPATKPCAWPTPNFSPLPPSPPVMISSPPGKATGPRPVLPVCVSSPVPPMPPSPTAPSGLLDSVPHPVSPPPTSGPAAPPPPPPLPSLAPLSHCGSQASPPPPPSTPLASTPSSKPSVLPSPSAAAPASVETPLNSVLGDSSAPEPGLQAASQPAETPAQQGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 797, "header": "tr|F1N214-1|F1N214_BOVIN Isoform 1 of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=3 CANONICAL=F1N214-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY87-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY87/entry", "sequence": { "sequence": "MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAAPSSDSSLYSAPLPEYASCQPPSAPPPSYAKVISAPVSEATPEYAVVTALPPTSTPPTPPLRHPATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSPQPPATKPCAWPTPNFSPLPPSPPVMISSPPGKATGPRPVLPVCVSSPVPPMPPSPTAPSGLLDSVPHPVSPPPTSGPAAPPPPPPLPSLAPLSHCGSQASPPPPPSTPLASTPSSKPSVLPSPSAAAPASVETPLNSVLGDSSAPEPGLQAASQPAETPAQQGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 779, "header": "tr|A0A3Q1LY87-1|A0A3Q1LY87_BOVIN Computationally mapped isoform of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=1 CANONICAL=F1N214-1" }, "locus": { "chromosome": "16", "start_pos": 28689825, "end_pos": 28535633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084831.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084831.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060596.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060596.1" } ] } }, { "isoform_ac": "A0AAA9SJ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ25/entry", "sequence": { "sequence": "MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETVFYLGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAAPSSDSSLYSAPLPEYASCQPPSAPPPSYAKVISAPVSEATPEYAVVTALPPTSTPPTPPLRHPATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSPQPPATKPCAWPTPNFSPLPPSPPVMISSPPGKATGPRPVLPVCVSSPVPPMPPSPTAPSGLLDSVPHPVSPPPTSGPAAPPPPPPLPSLAPLSHCGSQASPPPPPSTPLASTPSSKPSVLPSPSAAAPASVETPLNSVLGDSSAPEPGLQAASQPAETPAQQGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 783, "header": "tr|A0AAA9SJ25-1|F1N214_BOVIN Computationally mapped isoform of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=1 CANONICAL=F1N214-1" }, "locus": { "chromosome": "16", "start_pos": 28689825, "end_pos": 28535633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131537.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131537.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082568.1" } ] } }, { "isoform_ac": "A0AAA9SRA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA8/entry", "sequence": { "sequence": "MRVYCPQVSLQRQDGPRVDRLLLQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAAPSSDSSLYSAPLPEYASCQPPSAPPPSYAKVISAPVSEATPEYAVVTALPPTSTPPTPPLRHPATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSPQPPATKPCAWPTPNFSPLPPSPPVMISSPPGKATGPRPVLPVCVSSPVPPMPPSPTAPSGLLDSVPHPVSPPPTSGPAAPPPPPPLPSLAPLSHCGSQASPPPPPSTPLASTPSSKPSVLPSPSAAAPASVETPLNSVLGDSSAPEPGLQAASQPAETPAQQGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 678, "header": "tr|A0AAA9SRA8-1|F1N214_BOVIN Computationally mapped isoform of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=1 CANONICAL=F1N214-1" }, "locus": { "chromosome": "16", "start_pos": 28561739, "end_pos": 28535633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105334.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105334.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085507.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085507.1" } ] } }, { "isoform_ac": "A0AAA9TVH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH4/entry", "sequence": { "sequence": "MIYFAAEICGMSNAFFEDRVGEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAAAPASVETPLNSVLGDSSAPEPGLQAASQPAETPAQQGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 568, "header": "tr|A0AAA9TVH4-1|F1N214_BOVIN Computationally mapped isoform of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=2 CANONICAL=F1N214-1" }, "locus": { "chromosome": "16", "start_pos": 28610680, "end_pos": 28535633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102167.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102167.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102363.2", "url": "https://www.ensembl.org/id/ENSBTAP00000102363.2" } ] } }, { "isoform_ac": "A0AAA9U218-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U218/entry", "sequence": { "sequence": "MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 533, "header": "tr|A0AAA9U218-1|F1N214_BOVIN Computationally mapped isoform of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=2 CANONICAL=F1N214-1" }, "locus": { "chromosome": "16", "start_pos": 28689825, "end_pos": 28535633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102270.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102270.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103395.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103395.2" } ] } }, { "isoform_ac": "F1N214-1", "url": "https://www.uniprot.org/uniprotkb/F1N214/entry", "sequence": { "sequence": "SEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERMERERLERERLERERLEQEQLERERQERERQDRLERERQERERLERLDRERQERERQEQLEREQLEWERERRISNAAPSSDSSLYSAPLPEYASCQPPSAPPPSYAKVISAPVSEATPEYAVVTALPPTSTPPTPPLRHPATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSPQPPATKPCAWPTPNFSPLPPSPPVMISSPPGKATGPRPVLPVCVSSPVPPMPPSPTAPSGLLDSVPHPVSPPPTSGPAAPPPPPPLPSLAPLSHCGSQASPPPPPSTPLASTPSSKPSVLPSPSAAAPASVETPLNSVLGDSSAPEPGLQAASQPAETPAQQGIVLGPPAPPPPPPLPPGPAQAPAILPPPPGPPPPPPLPSSGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFSGSMSEDNRPLTGLAAAIAGAKLRKVSRMEDASFPSGGNTTGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKNEDSEPVTSKASSTTTPEPIRKPWERTNTMNGSKSPVISRPKSAPSSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 797, "header": "tr|F1N214-1|F1N214_BOVIN Isoform 1 of Protein enabled homolog OS=Bos taurus OX=9913 GN=ENAH PE=1 SV=3 CANONICAL=F1N214-1" }, "locus": { "chromosome": "16", "start_pos": 28609618, "end_pos": 28535633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021544.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021544.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021544.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021544.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 319, "start_aa": "Thr", "end_pos": 319, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr319", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 322, "start_aa": "Thr", "end_pos": 322, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr322", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 425, "start_aa": "Thr", "end_pos": 425, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr425", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 443, "start_aa": "Thr", "end_pos": 443, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr443", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 481, "start_aa": "Thr", "end_pos": 481, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr481", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GMP8-1", "protein_name": "Protein enabled homolog", "gene_name": "Enah", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCVFYLGPTLPRQNSQLPAQVQNGPSQEEMEIQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQDRERERERLEQLEREQVEWERERRMSNAAPSSDSSLYSAPLPEYSSCQPPSAPPPSYAKVISAPVSDAAPDYAVVTALPPTSTPPTPPLRHSATRFATSLGSAFHPVLPHYATVPRPLNRNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPPPPPPPPPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAAAPASVETPLNPELGDSSASEPGLQAASQPAETPAPQGHVLGPPAPPPPPPLPSGPAYASALPPPPGPPPPPPLPSAGPPPPPPPPPPLPNQVPPPPPPPPAPPLPASGIFSGSMSEDNRPLTGLAAAIAGAKLRKVSRVEDGSFPSGGNTVSVNLASSKTDSGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRSEDAEPVTSKAASTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELSKSNTA", "length": 807 }, "evidence": [ { "id": "F1N214", "url": "https://omabrowser.org/oma/group/F1N214/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M3B449-1", "protein_name": "Protein enabled homolog", "gene_name": "enah", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQLQSAAQCKVSGFILNERCALSSKMEVHREQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNAFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQDAGPPLPRQTPQVQNGPSPEELEVQRRQLQELQRQKEKEQERLDRERQERERQEREMLERERTERERQDRERQDRERQERERLERERTEQERLERERQEQELLERERQERELIERERAEREKQEREQQEQLDREQMDWERGRRISNAAFESTLYTPPPPEYNKTTSSSPVSPSTPSYPPPAPLPSTATPPTPPLRHSASRFATSLGSAFHPVLPHYATVPRRQPAPPTPPPPAPAPPPPSKSVIWTANNFTPLPPSPPVMISSPPGKATGPRPMIAIPAPSPLSQKPPSPISAPNGPPTSLHFHTSSPVSGQPFSSPPTPPPPPPLYSPSPTLPHLAPHVSCPSPQPAVLPSPSTAFPASAEHSVNSGLGDSCFSAPEPPTHPADFPSQPDSAHGVPTPPPPPPLPPSSTVTPTTAGPPPPPGPPPPPPPLPPTLTPTGPPPPPGPPPPPSGQAPPPAPPPPPAPPLPSGLFTPSPTTDENKGLSGLAAALAGAKLKKVPRSDEPLAPAAGPAVSSGGAKPEASRGNGPLPGGGGLMEEMSALLARRRRIAEKGSSPEPEQKADDFEATVTPKVSACSTPDMPRKPWERTNTMNGSKSPVIGRRDTPWRNQMGTDKYYDSLNRPRSTPTPTGSISANGVPTEALDYDRLKQDILEEMRKELSKLKEELIDAIREELGKSNSA", "length": 824 }, "evidence": [ { "id": "F1N214", "url": "https://omabrowser.org/oma/group/F1N214/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q03173-1", "protein_name": "Protein enabled homolog", "gene_name": "Enah", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQERERERLEQLEREQVEWERERRMSNAAPSSDSSLSSAPLPEYSSCQPPSAPPPSYAKVISAPVSDATPDYAVVTALPPTSTPPTPPLRHAATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPPPPPPPPLPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAGAPASAETPLNPELGDSSASEPGLQAASQPAESPTPQGLVLGPPAPPPPPPLPSGPAYASALPPPPGPPPPPPLPSTGPPPPPPPPPPLPNQAPPPPPPPPAPPLPASGIFSGSTSEDNRPLTGLAAAIAGAKLRKVSRVEDGSFPGGGNTGSVSLASSKADAGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRNEDAEPITAKAPSTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELSKSNTA", "length": 802 }, "evidence": [ { "id": "F1N214", "url": "https://omabrowser.org/oma/group/F1N214/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N8S7-1", "protein_name": "Protein enabled homolog", "gene_name": "ENAH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA", "length": 591 }, "evidence": [ { "id": "F1N214", "url": "https://omabrowser.org/oma/group/F1N214/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "WW domain binding", "id": "GO:0050699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050699", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N214", "url": "https://www.uniprot.org/uniprotkb/F1N214" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 731, "end_pos": 733, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N214-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 797, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N214-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N214" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N214" }, { "id": "PS50229", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50229" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WH1", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 110, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 319, 322, 425, 443, 481 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 383, "end_pos": 385 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 644, "end_pos": 646 }, { "start_pos": 731, "end_pos": 733 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3L2-1", "uniprot_ac": "F1N3L2", "uniprot_id": "F1N3L2_BOVIN", "mass": { "chemical_mass": 72809.0, "monoisotopic_mass": 72809.0 }, "refseq": {}, "gene_names": [ { "name": "ABCG5", "type": "recommended", "evidence": [ { "id": "F1N3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ] } ], "protein_names": [ { "name": "ATP binding cassette subfamily G member 5", "type": "synonym", "evidence": [ { "id": "F1N3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3L2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCG5", "url": "https://www.uniprot.org/uniprotkb/F1N3L2", "locus": { "chromosome": "11", "start_pos": 26047011, "end_pos": 26090950, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016365", "url": "https://www.ensembl.org/id/ENSBTAG00000016365" } ] } } ], "crossref": [ { "id": "F1N3L2", "url": "https://alphafold.ebi.ac.uk/entry/F1N3L2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016365", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016365", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3L2", "url": "https://www.orthodb.org/?gene=F1N3L2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48041", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48041", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48041:SF113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48041:SF113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1369062", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1369062", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3L2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3L2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGELPFLTLGESSELQVNRSSQCSLEEVPKASHSLGIFHASYSVSHHVGPWWDIASRRQKWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLRRTGTLLGEVFVNGQELHREQFQDCFSYVLQSDTLLSNLTVRETLNYTALLAIRRGSQSFFQKKVEAVMTELSLSHVADQLIGNYSFGGISHGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLAELARRDRIVILTIHQPRSELFQLFDKIAILSCGELVFCGTPVEMLDFFSGCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETYRRVQMIEVAYRESAMYHKTMEAIERTKHLKTLPKIPFKTRDSPGALSKLCVLLRRVMRNLLRNKLAVTMRLTQNLIMGLFIIFFLLRLGKDVLKGAVQDRVGLLYQFVGAMPYTGMLNAVTLFPVLRAVSDQESQDGLYHKWQMLLAYMLHVLPFSVTATLVCCSVCYWTLALYPEAARFAYFSVALLAPHLIGEFLSLVLLGVIQNPNVVNSVVALLSIAGVLMGSGFVRNIQEMPIPFKILGYFTFQKYCSEILVVNEFYGQNFTCGNSNASVSANPMCTITQGAQFIERNCPGATSRFTANFLILYSFIPALVILGIIVFKIRDYLISR", "length": 648, "header": "tr|F1N3L2-1|F1N3L2_BOVIN Isoform 1 of ATP binding cassette subfamily G member 5 OS=Bos taurus OX=9913 GN=ABCG5 PE=3 SV=2 CANONICAL=F1N3L2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ88/entry", "sequence": { "sequence": "MFRIFFWPQGTWDLSSLTRDQTCTPEFGVQSLSYWTTREVPTCLFLKGSGKTTLLDAMSGRLRRTGTLLGEVFVNGQELHREQFQDCFSYVLQSDTLLSNLTVRETLNYTALLAIRRGSQSFFQKKVEAVMTELSLSHVADQLIGNYSFGGISHGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLAELARRDRIVILTIHQPRSELFQLFDKIAILSCGELVFCGTPVEMLDFFSGCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETYRRVQMIEVAYRESAMYHKTMEAIERTKHLKTLPKIPFKTRDSPGALSKLCVLLRRVMRNLLRNKLAVTMRLTQNLIMGLFIIFFLLRLGKDVLKGAVQDRVGLLYQFVGAMPYTGMLNAVTLFPVLRAVSDQESQDGLYHKWQMLLAYMLHVLPFSVTATLVCCSVCYWTLALYPEAARFAYFSVALLAPHLIGEFLSLVLLGVIQNPNVVNSVVALLSIAGVLMGSGFVRNIQEMPIPFKILGYFTFQKYCSEILVVNEFYGQNFTCGNSNASVSANPMCTITQGAQFIERNCPGATSRFTANFLILYSFIPALVILGIIVFKIRDYLISR", "length": 610, "header": "tr|A0AAA9SJ88-1|F1N3L2_BOVIN Computationally mapped isoform of ATP binding cassette subfamily G member 5 OS=Bos taurus OX=9913 GN=ABCG5 PE=3 SV=1 CANONICAL=F1N3L2-1" }, "locus": { "chromosome": "11", "start_pos": 26082438, "end_pos": 26047019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099102.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099102.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082644.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082644.1" } ] } }, { "isoform_ac": "A0AAA9TLT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLT6/entry", "sequence": { "sequence": "MGPCSVCALTLQFPLGLAAADQGQCCLLPRAGQPLVWLPAFLSGKPSHKHGLCALPAAEITHRHTLAKGTSDNGIHDQAQARRWEVLRRGSRASHHVGPWWDIASRRQKWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLRRTGTLLGEVFVNGQELHREQFQDCFSYVLQSDTLLSNLTVRETLNYTALLAIRRGSQSFFQKKVEAVMTELSLSHVADQLIGNYSFGGISHGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLAELARRDRIVILTIHQPRSELFQLFDKIAILSCGELVFCGTPVEMLDFFSGCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETYRRVQMIEVAYRESAMYHKTMEAIERTKHLKTLPKIPFKTRDSPGALSKLCVLLRRVMRNLLRNKLAVTMRLTQNLIMGLFIIFFLLRLGKDVLKGAVQDRVGLLYQFVGAMPYTGMLNAVTLFPVLRAVSDQESQDGLYHKWQMLLAYMLHVLPFSVTATLVCCSVCYWTLALYPEAARFAYFSVALLAPHLIGEFLSLVLLGVIQNPNVVNSVVALLSIAGVLMGSGFVRNIQEMPIPFKILGYFTFQKYCSEILVVNEFYGQNFTCGNSNASVSANPMCTITQGAQFIERNCPGATSRFTANFLILYSFIPALVILGIIVFKIRDYLISR", "length": 697, "header": "tr|A0AAA9TLT6-1|F1N3L2_BOVIN Computationally mapped isoform of ATP binding cassette subfamily G member 5 OS=Bos taurus OX=9913 GN=ABCG5 PE=3 SV=1 CANONICAL=F1N3L2-1" }, "locus": { "chromosome": "11", "start_pos": 26079432, "end_pos": 26047019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124490.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124490.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097263.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097263.1" } ] } }, { "isoform_ac": "A0AAA9TWM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWM4/entry", "sequence": { "sequence": "MLPTRVLAHCRSRSSAITSSTWCLFPDSFHASGAAPTAEQGTTCWDCGHVPAPRQHGEPENNHHVGPWWDIASRRQKWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLRRTGTLLGEVFVNGQELHREQFQDCFSYVLQSDTLLSNLTVRETLNYTALLAIRRGSQSFFQKKVEAVMTELSLSHVADQLIGNYSFGGISHGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLAELARRDRIVILTIHQPRSELFQLFDKIAILSCGELVFCGTPVEMLDFFSGCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETYRRVQMIEVAYRESAMYHKTMEAIERTKHLKTLPKIPFKTRDSPGALSKLCVLLRRVMRNLLRNKLAVTMRLTQNLIMGLFIIFFLLRLGKDVLKGAVQDRVGLLYQFVGAMPYTGMLNAVTLFPVLRAVSDQESQDGLYHKWQMLLAYMLHVLPFSVTATLVCCSVCYWTLALYPEAARFAYFSVALLAPHLIGEFLSLVLLGVIQNPNVVNSVVALLSIAGVLMGSGFVRNIQEMPIPFKILGYFTFQKYCSEILVVNEFYGQNFTCGNSNASVSANPMCTITQGAQFIERNCPGATSRFTANFLILYSFIPALVILGIIVFKIRDYLISR", "length": 665, "header": "tr|A0AAA9TWM4-1|F1N3L2_BOVIN Computationally mapped isoform of ATP binding cassette subfamily G member 5 OS=Bos taurus OX=9913 GN=ABCG5 PE=3 SV=1 CANONICAL=F1N3L2-1" }, "locus": { "chromosome": "11", "start_pos": 26090751, "end_pos": 26047019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134921.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134921.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103053.1" } ] } }, { "isoform_ac": "F1N3L2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3L2/entry", "sequence": { "sequence": "MGELPFLTLGESSELQVNRSSQCSLEEVPKASHSLGIFHASYSVSHHVGPWWDIASRRQKWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLRRTGTLLGEVFVNGQELHREQFQDCFSYVLQSDTLLSNLTVRETLNYTALLAIRRGSQSFFQKKVEAVMTELSLSHVADQLIGNYSFGGISHGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLAELARRDRIVILTIHQPRSELFQLFDKIAILSCGELVFCGTPVEMLDFFSGCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETYRRVQMIEVAYRESAMYHKTMEAIERTKHLKTLPKIPFKTRDSPGALSKLCVLLRRVMRNLLRNKLAVTMRLTQNLIMGLFIIFFLLRLGKDVLKGAVQDRVGLLYQFVGAMPYTGMLNAVTLFPVLRAVSDQESQDGLYHKWQMLLAYMLHVLPFSVTATLVCCSVCYWTLALYPEAARFAYFSVALLAPHLIGEFLSLVLLGVIQNPNVVNSVVALLSIAGVLMGSGFVRNIQEMPIPFKILGYFTFQKYCSEILVVNEFYGQNFTCGNSNASVSANPMCTITQGAQFIERNCPGATSRFTANFLILYSFIPALVILGIIVFKIRDYLISR", "length": 648, "header": "tr|F1N3L2-1|F1N3L2_BOVIN Isoform 1 of ATP binding cassette subfamily G member 5 OS=Bos taurus OX=9913 GN=ABCG5 PE=3 SV=2 CANONICAL=F1N3L2-1" }, "locus": { "chromosome": "11", "start_pos": 26079051, "end_pos": 26047019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021768.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021768.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021768.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021768.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1369062", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1369062", "resource": "Reactome", "description": "ABC transporters in lipid homeostasis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "cholesterol transfer activity", "id": "GO:0120020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120020", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "ATP-binding cassette (ABC) transporter complex", "id": "GO:0043190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043190", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of intestinal phytosterol absorption", "id": "GO:0010949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010949", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "cholesterol efflux", "id": "GO:0033344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033344", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "negative regulation of intestinal cholesterol absorption", "id": "GO:0045796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045796", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1N3L2", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3L2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 648, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3L2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3L2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3L2" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 290, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 18, "end_pos": 20 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 588, "end_pos": 590 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5P0-1", "uniprot_ac": "F1N5P0", "uniprot_id": "F1N5P0_BOVIN", "mass": { "chemical_mass": 77223.0, "monoisotopic_mass": 77223.0 }, "refseq": { "ac": "XP_003585822", "name": "delta and Notch-like epidermal growth factor-related receptor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585822" }, "gene_names": [ { "name": "DNER", "type": "recommended", "evidence": [ { "id": "F1N5P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ] }, { "name": "DNER", "type": "synonym", "evidence": [ { "id": "XP_003585822", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585822" } ] } ], "protein_names": [ { "name": "Delta/notch like EGF repeat containing", "type": "synonym", "evidence": [ { "id": "F1N5P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P0/entry#names_and_taxonomy" } ] }, { "name": "delta and Notch-like epidermal growth factor-related receptor", "type": "synonym", "evidence": [ { "id": "XP_003585822", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585822" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNER", "url": "https://www.uniprot.org/uniprotkb/F1N5P0", "locus": { "chromosome": "2", "start_pos": 117379825, "end_pos": 117771075, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016063", "url": "https://www.ensembl.org/id/ENSBTAG00000016063" } ] } } ], "crossref": [ { "id": "F1N5P0", "url": "https://alphafold.ebi.ac.uk/entry/F1N5P0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016063", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016063", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516825", "url": "https://www.ncbi.nlm.nih.gov/gene/516825", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516825", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516825", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CECEDAY", "url": "https://omabrowser.org/oma/group/CECEDAY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N5P0", "url": "https://www.orthodb.org/?gene=F1N5P0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12916", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12916:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24049:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24049:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19330", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19330", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003585822", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585822", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5P0-1", "url": "https://www.uniprot.org/uniprotkb/F1N5P0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPRRAPAPALLLLLLLGAGPRSGCLASPVPAAPLPVPGPCSAQPCQNGGVCSQLPAPDPQSPAAAGEPGYSCTCPAGVSGTNCQLVADPCTSNPCHHGNCSSSSSDGYLCICNEGYEGPNCEQALSSVPASGWTESTAPRQLQPVPATQEPEIMLPRSQATITLPTWQPKTGQKVVEMKWDQVEVVPDIACGNASANSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTLLQAPGGLVLLEEMLALGQNHFIGFVNDSITKSIVALRLTLVVKTSTCVPGESRANDLECSGRGRCSTKPSEATFSCNCDDQYTGTFCEEFDACQKKPCQNNASCVDAKEKQDGGNFTCVCLAGYTGELCQSKIDYCILDPCRNGATCTSNLSGFTCQCLEGYLGSTCEEKVDPCASAPCQNNGTCYADGLHFGCSCSAGFTGPACAQLVDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYDECVSAPCLNAATCRDLVNGYECVCLAEYKGIHCESYKDPCANVSCLNGGTCDSEGLNGTCVCTPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSARPAYEDFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL", "length": 727, "header": "tr|F1N5P0-1|F1N5P0_BOVIN Isoform 1 of Delta/notch like EGF repeat containing OS=Bos taurus OX=9913 GN=DNER PE=4 SV=3 CANONICAL=F1N5P0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA4/entry", "sequence": { "sequence": "MQPRRAPAPALLLLLLLGAGPRSGCLASPVPAAPLPVPGPCSAQPCQNGGVCSQLPAPDPQSPAAAGEPGYSCTCPAGVSGTNCQLVADPCTSNPCHHGNCSSSSSDGYLCICNEGYEGPNCEQALSSVPASGWTESTAPRQLQPVPATQEPEIMLPRSQATITLPTWQPKTGQKVVEMKWDQVEVVPDIACGNASANSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTLLQAPGGLVLLEEMLALGQNHFIGFVNDSITKSIVALRLTLVVKTSTCVPGESRANDLECSGRGRCSTKPSEATFSCNCDDQYTGTFCEEFDACQKKPCQNNASCVDAKEKQDGGNFTCVCLAGYTGELCQSKIDYCILDPCRNGATCTSNLSGFTCQCLEGYLGSTCEEKVDPCASAPCQNNGTCYADGLHFGCSCSAGFTGPACAQLVDFCALSPCAHGTCRSVGTSYKCLCDPGIHCESYKDPCANVSCLNGGTCDSEGLNGTCVCTPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSARPAYEDFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL", "length": 686, "header": "tr|A0AAA9SJA4-1|F1N5P0_BOVIN Computationally mapped isoform of Delta/notch like EGF repeat containing OS=Bos taurus OX=9913 GN=DNER PE=4 SV=1 CANONICAL=F1N5P0-1" }, "locus": { "chromosome": "2", "start_pos": 117770913, "end_pos": 117380738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083982.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083982.1" } ] } }, { "isoform_ac": "A0AAA9TT51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT51/entry", "sequence": { "sequence": "MQPRRAPAPALLLLLLLGAGPRSGCLASPVPAAPLPVPGPCSAQPCQNGGVCSQLPAPDPQSPAAAGEPGYSCTCPAGVSGTNCQLVADPCTSNPCHHGNCSSSSSDGYLCICNEGYEGPNCEQALSSVPASGWTESTAPRQLQPVPATQEPEIMLPRSQATITLPTWQPKTGQKVVEMKWDQVEVVPDIACGNASANSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTLLQAPGGLVLLEEMLALGQNHFIGFVNDSITKSIVALRLTLVVKTSTCVPGESRANDLECSGRGRCSTKPSEATFSCNCDDQYTGTFCEEFDACQKKPCQNNASCVDAKEKQDGGNFTCVCLAGYTGELCQSKIDYCILDPCRNGATCTSNLSGFTCQCLEGYLGSTCEEKVDPCASAPCQNNGTCYADGLHFGCSCSAGFTGPACAQLVDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYDECVSAPCLNAATCRDLVNGYECVCLAEYKGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSARPAYEDFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL", "length": 689, "header": "tr|A0AAA9TT51-1|F1N5P0_BOVIN Computationally mapped isoform of Delta/notch like EGF repeat containing OS=Bos taurus OX=9913 GN=DNER PE=4 SV=1 CANONICAL=F1N5P0-1" }, "locus": { "chromosome": "2", "start_pos": 117770913, "end_pos": 117380738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125968.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125968.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101798.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101798.1" } ] } }, { "isoform_ac": "F1N5P0-1", "url": "https://www.uniprot.org/uniprotkb/F1N5P0/entry", "sequence": { "sequence": "MQPRRAPAPALLLLLLLGAGPRSGCLASPVPAAPLPVPGPCSAQPCQNGGVCSQLPAPDPQSPAAAGEPGYSCTCPAGVSGTNCQLVADPCTSNPCHHGNCSSSSSDGYLCICNEGYEGPNCEQALSSVPASGWTESTAPRQLQPVPATQEPEIMLPRSQATITLPTWQPKTGQKVVEMKWDQVEVVPDIACGNASANSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTLLQAPGGLVLLEEMLALGQNHFIGFVNDSITKSIVALRLTLVVKTSTCVPGESRANDLECSGRGRCSTKPSEATFSCNCDDQYTGTFCEEFDACQKKPCQNNASCVDAKEKQDGGNFTCVCLAGYTGELCQSKIDYCILDPCRNGATCTSNLSGFTCQCLEGYLGSTCEEKVDPCASAPCQNNGTCYADGLHFGCSCSAGFTGPACAQLVDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYDECVSAPCLNAATCRDLVNGYECVCLAEYKGIHCESYKDPCANVSCLNGGTCDSEGLNGTCVCTPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSARPAYEDFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL", "length": 727, "header": "tr|F1N5P0-1|F1N5P0_BOVIN Isoform 1 of Delta/notch like EGF repeat containing OS=Bos taurus OX=9913 GN=DNER PE=4 SV=3 CANONICAL=F1N5P0-1" }, "locus": { "chromosome": "2", "start_pos": 117770913, "end_pos": 117380738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021383.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021383.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021383.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021383.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516825", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516825", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1W2Q656-1", "protein_name": "Delta and Notch-like epidermal growth factor-related receptor", "gene_name": "Dner", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPRRAQAPGAPLLPVLALLPLLLGAGPQSSCLASPVPAAPLPAPGPCASQPCRNGGVCTPRSVTDQEHPAVDAEPGYSCTCPAGVSGTDCQFVADPCASNPCHHGNCSSSSSSSSSSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESMAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDATALLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLTLGPNHFIGFVNDSVAKSIVALRLTLVVKASTCVPGDGHSNDIECSGKGKCATKPSEATFSCTCEDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL", "length": 746 }, "evidence": [ { "id": "F1N5P0", "url": "https://omabrowser.org/oma/group/F1N5P0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1A115-1", "protein_name": "Delta/notch like EGF repeat containing", "gene_name": "DNER", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRAAPPLLLLLLLALAQRRSCLPGPVTAAPPGSDPCLGRPCRNNGTCFPAAPRRLPSAAAYRCVCPPGVTGASCQFISDPCASNPCHHGNCSTSGDGYLCACSDGYEGANCEHSRHSPPLPEQAEASSPRQSRPVTSTLEPDVILPHSRATVTLPTWQPRAGQKVVDLKWDEIEILPDVACGNASSNSSAGGRLVSFEVPQNTSIKIRQDATASLILLWKVTTAGFKQCSLIDGRSVTLLQALGGLVLSEEMLALGNNFFIGFLNDSVTKCIVALRLTVIVKVSTCTPAGSHSDKFQCSGKGKCITKPDEATFFCECEDEYRGPLCEEFDACQSQPCQNNATCTDLPQKHNGNNFTCSCLPGYTGELCQSEIDHCIQQPCQNGGTCSSNIHGFTCQCPEGFLGTSCEEKIDPCASSPCQNNGTCYADRLVYSCSCSSGFTGPTCAQLIDFCALNPCAHGICRSVGTSYKCLCSPGYHGLYCEEEYNECLSTPCQNGATCRDLENGYKCLCLAEYEGSLCELYKDPCVNINCQNGGTCDSEGLNATCICAPGYAGEECEIDINDCDSNPCHHAGTCIDQPGGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFVLMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDATPIAYEDYSPDDKPLVTLIKTKDL", "length": 717 }, "evidence": [ { "id": "F1N5P0", "url": "https://omabrowser.org/oma/group/F1N5P0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SMZ4-1", "protein_name": "Delta and Notch-like epidermal growth factor-related receptor", "gene_name": "DNER", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQPRRVSVPGAQLLPAPALLLLLLGAGPRSGCLANPVPAAPLPVPGPCAAQPCRNGGVCTPRPEPGPQSPATAGEPAYSCTCPAGVSGANCQLVADPCASNPCRHGNCSSSSSSSSSNGYLCICSEGYEGPNCEEALPSVPTNGWTESMAPRQLQPVPATQEPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQAEVAPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFRQCSLIDGRSVTLLQAPGGLVLLEEMLALGQNHFIGFVNDSVTKSIVALRLTLVVKASTCVPGESRANDLECSGKGRCTTKPSEATFSCDCDDQYTGTFCEEFDACQRKPCLNNASCVDANEKQDGGNFTCVCLAGYTGELCQSKIDYCVLDPCRNGATCISHLSGFTCQCPEGYLGATCEEKVDPCASSPCQNNGTCYADGLHFGCSCSAGFTGPACAQLVDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSSPCLNAATCRDLVNGYECVCLAEYKGIHCESYKDPCANISCLNGGTCDSEGLNGTCVCAPGFTGEDCDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL", "length": 738 }, "evidence": [ { "id": "F1N5P0", "url": "https://omabrowser.org/oma/group/F1N5P0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NFT8-1", "protein_name": "Delta and Notch-like epidermal growth factor-related receptor", "gene_name": "DNER", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKPLVTLIKTKDL", "length": 737 }, "evidence": [ { "id": "F1N5P0", "url": "https://omabrowser.org/oma/group/F1N5P0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" }, { "name": "Notch binding", "id": "GO:0005112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005112", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "F1N5P0", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5P0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 727, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5P0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5P0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P0" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 85, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 213, "end_pos": 215 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 351, "end_pos": 353 }, { "start_pos": 365, "end_pos": 367 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 539, "end_pos": 541 }, { "start_pos": 554, "end_pos": 556 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N730-1", "uniprot_ac": "F1N730", "uniprot_id": "F1N730_BOVIN", "mass": { "chemical_mass": 50749.0, "monoisotopic_mass": 50749.0 }, "refseq": { "ac": "XP_003586937", "name": "carboxypeptidase A6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586937" }, "gene_names": [ { "name": "CPA6", "type": "recommended", "evidence": [ { "id": "F1N730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N730" } ] }, { "name": "CPA6", "type": "synonym", "evidence": [ { "id": "XP_003586937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586937" } ] } ], "protein_names": [ { "name": "Carboxypeptidase A6", "type": "recommended", "evidence": [ { "id": "F1N730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N730/entry#names_and_taxonomy" } ] }, { "name": "carboxypeptidase A6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003586937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586937" } ] } ], "function": [ { "annotation": "May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG0#function" }, { "database": "UniProtKB", "id": "ARBA00057362", "url": "https://www.uniprot.org/uniprotkb/ARBA00057362#function" }, { "database": "UniProtKB", "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPA6", "url": "https://www.uniprot.org/uniprotkb/F1N730", "locus": { "chromosome": "14", "start_pos": 31534479, "end_pos": 31829214, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044080", "url": "https://www.ensembl.org/id/ENSBTAG00000044080" } ] } } ], "crossref": [ { "id": "F1N730", "url": "https://alphafold.ebi.ac.uk/entry/F1N730", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044080", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044080", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03872", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03872", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337371", "url": "https://www.ncbi.nlm.nih.gov/gene/100337371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100337371", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337371", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HQHAREH", "url": "https://omabrowser.org/oma/group/HQHAREH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N730", "url": "https://www.orthodb.org/?gene=F1N730", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11705", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11705", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11705:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11705:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02244", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02244", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003586937", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586937", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N730-1", "url": "https://www.uniprot.org/uniprotkb/F1N730-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFFGKPRSQTAAFLPLCLLFLKSLSLGHSNLYSNRYAGDKVIRLTPNTEEEAFVLKKICHQLKVDLWQPGGVSQISQGTVTDVHIPHNGSRALLTFLQEANIQYKILIEDLQKVLEKGSSLPAWRSRRSLSGYNYEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGKSYEGRSLYVLKLGRRSRAYKRAVWMDCGIHAREWIGPAFCQWFVKEALLTYRSDPTMRKTLNHLYFYIMPVFNVDGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWRVKWCDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRKHITAYLSFHAYAQMLLYPYSYKYATIPNFSCVESAAYKAVNALRSVHGVQYRYGPASSTLYVSSGSSMDWAYKNGIPYTFAFELRDTGHFGFLLPETLIKPTCTETMLAVKNITMHLLKKCP", "length": 438, "header": "tr|F1N730-1|F1N730_BOVIN Isoform 1 of Carboxypeptidase A6 OS=Bos taurus OX=9913 GN=CPA6 PE=3 SV=3 CANONICAL=F1N730-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG0/entry", "sequence": { "sequence": "MKFFGKPRSQTAAFLPLCLLFLKSLSLGHSNLYSNRYAGDKVIRLTPNTEEEAFVLKKICHQLKVDLWQPGGVSQISQGTVTDVHIPHNGSRALLTFLQEANIQYKILIEDLQKVLEKGSSLPAWRSRRSLSGYNYEVYHSLEELGRRSRAYKRAVWMDCGIHAREWIGPAFCQWFVKEALLTYRSDPTMRKTLNHLYFYIMPVFNVDGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWRVKWCDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRKHITAYLSFHAYAQMLLYPYSYKYATIPNFSCVESAAYKAVNALRSVHGVQYRYGPASSTLYVSSGSSMDWAYKNGIPYTFAFELRDTGHFGFLLPETLIKPTCTETMLAVKNITMHLLKKCP", "length": 404, "header": "tr|A0AAA9SKG0-1|F1N730_BOVIN Computationally mapped isoform of Carboxypeptidase A6 OS=Bos taurus OX=9913 GN=CPA6 PE=3 SV=1 CANONICAL=F1N730-1" }, "locus": { "chromosome": "14", "start_pos": 31829014, "end_pos": 31534792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090661.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090661.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085780.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085780.1" } ] } }, { "isoform_ac": "F1N730-1", "url": "https://www.uniprot.org/uniprotkb/F1N730/entry", "sequence": { "sequence": "MKFFGKPRSQTAAFLPLCLLFLKSLSLGHSNLYSNRYAGDKVIRLTPNTEEEAFVLKKICHQLKVDLWQPGGVSQISQGTVTDVHIPHNGSRALLTFLQEANIQYKILIEDLQKVLEKGSSLPAWRSRRSLSGYNYEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGKSYEGRSLYVLKLGRRSRAYKRAVWMDCGIHAREWIGPAFCQWFVKEALLTYRSDPTMRKTLNHLYFYIMPVFNVDGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWRVKWCDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRKHITAYLSFHAYAQMLLYPYSYKYATIPNFSCVESAAYKAVNALRSVHGVQYRYGPASSTLYVSSGSSMDWAYKNGIPYTFAFELRDTGHFGFLLPETLIKPTCTETMLAVKNITMHLLKKCP", "length": 438, "header": "tr|F1N730-1|F1N730_BOVIN Isoform 1 of Carboxypeptidase A6 OS=Bos taurus OX=9913 GN=CPA6 PE=3 SV=3 CANONICAL=F1N730-1" }, "locus": { "chromosome": "14", "start_pos": 31829014, "end_pos": 31534792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061366.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061366.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053690.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053690.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100337371", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337371", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E7F2H8-1", "protein_name": "Carboxypeptidase A6", "gene_name": "cpa6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALRSTDVSSNVKSAVLLGCVLILCTAPNNVDSYLYNNRYVGDQVFRIIPSSKPEVQAVKQLFQNLTVDLWQPNSASLIRENSSIDVHVRRDKTHWLRNHLHQEHIYYEVLISNLQTEIEKQTGYRSSRKRRSELQYDYEVYHPLEEIQSWMFEMNRTHSHLVDLFSIGQSYEGRPLYVLQLGKRTRFFKKAVWIDCGVHAREWIGPAFCQWFVKEALNSYQHDSSMRRLMNQLNFYIMPVFNVDGYHYSWKMDRFWRKTRSKIPKYHCRGVDANRNWKVKWCDEGASLHPCDDTYCGPFPESEPEVKAVAKFLRKHKKRVKAYISMHAYAQMLLYPYSYKYATIPNFNCVESAAQNAVSALYSAYGVRYRYGPASSTLYVSSGSSMDWAYKNGIPYAFAFELRDTGYYGFLLPEALINPTCTETMRAVKTIASGLLRKCTK", "length": 442 }, "evidence": [ { "id": "F1N730", "url": "https://omabrowser.org/oma/group/F1N730/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M4P0-1", "protein_name": "Carboxypeptidase A6", "gene_name": "Cpa6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKFLGKPRSLTAAFLPVCCLLLKILQPGHCHSYDNRYAGHKVIRLIPKSEEEALALKSVSHQLKVDLWQPSSISYVSEGTITDVRVTQNASRTLLAILQETNIQYKVLIEDLQKAVENENSVHTQRNRRSLSEYNYEVYHSLEDIQSWMHHLNQTQPGLVRVFPIGRSFEGRSLLIIQLGRKSQVYKRAVWIDCGIHAREWIGPAFCQWFVKEAILTYKTDPAMRKMLNHLYFYIMPVLNVDGYHFSWTHDRFWRKTRSRNSKFHCRGVDANRNWKVKWCDEGASADPCDDTYCGPFPESEPEVKAVANFLRKHRKRIRAYLSFHAYAQMLLYPYSYKHATIPNFSCVEFAAHKAVKALRSVHGIRYRHGPASQTLYVSSGNSMDWAYKNGIPYSFAFELRDTGYFGFLLPEMLIKPTCTETMLAVKNITMHLLKNCP", "length": 438 }, "evidence": [ { "id": "F1N730", "url": "https://omabrowser.org/oma/group/F1N730/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "K7GM46-1", "protein_name": "Carboxypeptidase A6", "gene_name": "CPA6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKFLGKPRSPTAAFLPLCLLSLKILQPGHSHLYSNRYAGDKVIRLIPNTKDEAYALKKMYHHLKVDLWQPSSISYISEGTVTDVHIPQNGSRALLAFLQESNIQYKILIEDLQKALEKGSSLPTQRSRRSPSGYNYEVYHSLEEIQNWMRHLNKTHSGLIHMFSIGKSYEGRSLFVLKLGRRSRAYKRGVWIDCGIHAREWIGPAFCQWFVKEALLTYRSDPTMRKMLNHLYFYIMPVFNVDGYHFSWTNDRFWRKTRSRNSRFRCHGVDANRNWRVKWCDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRKHIRAYLSFHAYAQMLLYPYSYKYATIPNFSCVESAAHNAVNALRSVHGVQYRYGPASSTLYVSSGSSMDWAYKTGIPYTFAFELRDTGHFGFLLPEMLIKPTCMETMLAVKNITMHLLKKCP", "length": 438 }, "evidence": [ { "id": "F1N730", "url": "https://omabrowser.org/oma/group/F1N730/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P38836-1", "protein_name": "Inactive metallocarboxypeptidase ECM14", "gene_name": "ECM14", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLHMNSLWGCFLFVLLAVTGAVQGLQEDYSEYAVYRFTSDNYSTLVRDVIAPLTDDYDVWTRSNNFIDIKLPKEIGEQINDGQVIIDNMNELIQNTLPTSQMMAREQAVFENDYDFFFNEYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPESNPEKKTIVITGGIHAREWISVSTVCWALYQLLNRYGSSKKETKYLDDLDFLVIPVFNPDGYAYTWSHDRLWRKNRQRTHVPQCLGIDIDHSFGFQWEKAHTHACSEEYSGETPFEAWEASAWYKYINETKGDYKIYGYIDMHSYSQEILYPYAYSCDALPRDLENLLELSYGLSKAIRSKSGRNYDVISACKDRGSDIFPGLGAGSALDFMYHHRAHWAFQLKLRDTGNHGFLLPPENIKPVGKETYAALKYFCDFLLDPEI", "length": 430 }, "evidence": [ { "id": "F1N730", "url": "https://omabrowser.org/oma/group/F1N730/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5U901-1", "protein_name": "Carboxypeptidase A6", "gene_name": "Cpa6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFLGNPRSHTAAFLPVCWLLLNILKPGHCHSYDNRYAGDKVIRLIPKSEEEALALKNIYHQLKVDLWQPSSISYVSEGTITDVHISQNASRTLLAFLQETHIYYKVLIEDLQKAVENENSLQTQRNRRSLSEYNYEVYHSLEDIQSWLHHLNQTQPGLVRVFSIGRSYEGRPLFIMQLGRKSRAYKRAVWIDCGIHAREWIGPAFCQWFVREAILTYKTDPAMKKMLNHLYFYIMPVFNVDGYHFSWTHDRFWRKTRSRDSKFRCRGVDANRNWKVKWCDEGASAHPCDDTYCGPFPESEPEVKAVANFLRKHRKRIRAYLSFHAYAQMLLYPYSYKYATIPNFSCVEFAAHKAVKALRSVHGIRYRHGPASQTLYVSSGNSMDWAYKNGIPYAFAFELRDTGHFGFLLPEMLIKPTCTETMLAVKNITMHLLKKCP", "length": 438 }, "evidence": [ { "id": "F1N730", "url": "https://omabrowser.org/oma/group/F1N730/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N4T0-1", "protein_name": "Carboxypeptidase A6", "gene_name": "CPA6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKCLGKRRGQAAAFLPLCWLFLKILQPGHSHLYNNRYAGDKVIRFIPKTEEEAYALKKISYQLKVDLWQPSSISYVSEGTVTDVHIPQNGSRALLAFLQEANIQYKVLIEDLQKTLEKGSSLHTQRNRRSLSGYNYEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGRSYEGRSLFILKLGRRSRLKRAVWIDCGIHAREWIGPAFCQWFVKEALLTYKSDPAMRKMLNHLYFYIMPVFNVDGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWKVKWCDEGASMHPCDDTYCGPFPESEPEVKAVANFLRKHRKHIRAYLSFHAYAQMLLYPYSYKYATIPNFRCVESAAYKAVNALQSVYGVRYRYGPASTTLYVSSGSSMDWAYKNGIPYAFAFELRDTGYFGFLLPEMLIKPTCTETMLAVKNITMHLLKKCP", "length": 437 }, "evidence": [ { "id": "F1N730", "url": "https://omabrowser.org/oma/group/F1N730/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730" } ], "pmid": "" }, { "name": "metallocarboxypeptidase activity", "id": "GO:0004181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181", "evidence": [ { "database": "UniProtKB", "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N730", "url": "https://www.uniprot.org/uniprotkb/F1N730" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N730-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 438, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N730-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N730" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N730" }, { "id": "PS52035", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M14", "eco_id": "ECO_0000259", "start_pos": 138, "end_pos": 433, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N773-1", "uniprot_ac": "F1N773", "uniprot_id": "F1N773_BOVIN", "mass": { "chemical_mass": 117784.0, "monoisotopic_mass": 117784.0 }, "refseq": { "ac": "NP_001193442", "name": "connector enhancer of kinase suppressor of ras 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193442" }, "gene_names": [ { "name": "CNKSR2", "type": "recommended", "evidence": [ { "id": "F1N773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ] }, { "name": "CNKSR2", "type": "synonym", "evidence": [ { "id": "NP_001193442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193442" } ] } ], "protein_names": [ { "name": "Connector enhancer of kinase suppressor of Ras 2", "type": "synonym", "evidence": [ { "id": "F1N773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N773/entry#names_and_taxonomy" } ] }, { "name": "connector enhancer of kinase suppressor of ras 2", "type": "synonym", "evidence": [ { "id": "NP_001193442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193442" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNKSR2", "url": "https://www.uniprot.org/uniprotkb/F1N773", "locus": { "chromosome": "X", "start_pos": 121644936, "end_pos": 121953798, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044202", "url": "https://www.ensembl.org/id/ENSBTAG00000044202" } ] } } ], "crossref": [ { "id": "F1N773", "url": "https://alphafold.ebi.ac.uk/entry/F1N773", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044202", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044202", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06748", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06748", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09511", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09511", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534112", "url": "https://www.ncbi.nlm.nih.gov/gene/534112", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534112", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534112", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XAREGEV", "url": "https://omabrowser.org/oma/group/XAREGEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N773", "url": "https://www.orthodb.org/?gene=F1N773", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9U9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N773-1", "url": "https://www.uniprot.org/uniprotkb/F1N773-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSSSPTHYSLLPSLQMDALRQDIMGTPVPEATLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSVVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPTEVEEEEEEEEEEEEGEAAGENIGDKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV", "length": 1036, "header": "tr|F1N773-1|F1N773_BOVIN Isoform 1 of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=3 CANONICAL=F1N773-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM7/entry", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSSSPTHYSLLPSLQMDALRQDIMGTPVPEATLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSVVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPTEVEEEEEEEEEEEEGEAAGENIGDKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV", "length": 1006, "header": "tr|A0AAA9SLM7-1|F1N773_BOVIN Computationally mapped isoform of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=1 CANONICAL=F1N773-1" }, "locus": { "chromosome": "X", "start_pos": 121953599, "end_pos": 121647155, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103329.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103329.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086155.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086155.1" } ] } }, { "isoform_ac": "A0AAA9SUC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC2/entry", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSSSPTHYSLLPSLQMDALRQDIMGTPVPEATLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSVVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPTEVEEEEEEEEEEEEGEAAGENIGDKS", "length": 900, "header": "tr|A0AAA9SUC2-1|F1N773_BOVIN Computationally mapped isoform of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=1 CANONICAL=F1N773-1" }, "locus": { "chromosome": "X", "start_pos": 121953599, "end_pos": 121657783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122731.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122731.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086720.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086720.1" } ] } }, { "isoform_ac": "A0AAA9T9U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9U9/entry", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSSSPTHYSLLPSLQMDALRQDIMGTPVPEATLYHTFQQSSLQHKSKKKNKVWCGREPPPSTRATKISFSFRSIMVQGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSVVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPTEVEEEEEEEEEEEEGEAAGENIGDKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV", "length": 1013, "header": "tr|A0AAA9T9U9-1|F1N773_BOVIN Computationally mapped isoform of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=1 CANONICAL=F1N773-1" }, "locus": { "chromosome": "X", "start_pos": 121953599, "end_pos": 121647155, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130400.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130400.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094787.1" } ] } }, { "isoform_ac": "A0AAA9TDQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ9/entry", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVEYSKILETTQNDGWRNLLSVFALKLTYSFNGF", "length": 302, "header": "tr|A0AAA9TDQ9-1|F1N773_BOVIN Computationally mapped isoform of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=1 CANONICAL=F1N773-1" }, "locus": { "chromosome": "X", "start_pos": 121953599, "end_pos": 121787237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095028.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095028.1" } ] } }, { "isoform_ac": "A0AAA9TUQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUQ2/entry", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSVVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPTEVEEEEEEEEEEEEGEAAGENIGDKS", "length": 683, "header": "tr|A0AAA9TUQ2-1|F1N773_BOVIN Computationally mapped isoform of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=1 CANONICAL=F1N773-1" }, "locus": { "chromosome": "X", "start_pos": 121953599, "end_pos": 121657783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127330.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127330.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100858.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100858.1" } ] } }, { "isoform_ac": "F1N773-1", "url": "https://www.uniprot.org/uniprotkb/F1N773/entry", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSSSPTHYSLLPSLQMDALRQDIMGTPVPEATLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSVVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPTEVEEEEEEEEEEEEGEAAGENIGDKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV", "length": 1036, "header": "tr|F1N773-1|F1N773_BOVIN Isoform 1 of Connector enhancer of kinase suppressor of Ras 2 OS=Bos taurus OX=9913 GN=CNKSR2 PE=3 SV=3 CANONICAL=F1N773-1" }, "locus": { "chromosome": "X", "start_pos": 121953599, "end_pos": 121647155, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061509.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061509.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053655.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053655.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 332, "start_aa": "Thr", "end_pos": 332, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr332", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534112", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534112", "resource": "KEGG Pathway" }, { "id": "R-BTA-5674135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "resource": "Reactome", "description": "MAP2K and MAPK activation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XDZ9-1", "protein_name": "Connector enhancer of kinase suppressor of Ras 2", "gene_name": "CNKSR2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVTRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLTNIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPTEPYVPRDEKGNLPCDDVGRHTVGKPVHTGSESPNSFLDQEYRKRFNVVEEDAVLYCYEYDKGRTSGPGRRESTPTYGKLRPISMPVEYNWVGDYEDPSKIKRDSRRENSLLRYMSNEKIGQEDYMFQRNSKKDTGKKSKKKGDKGNSPSHYSLLPSLQMDSLRQDVIGTPGPETTLYHTFQQSSLQQKSKKKNKAPIPGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDTSLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLAAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCTSPYVEPKHSRLSSTETSQSQSSHEEFRPEAAGSVTDSPVRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSETAVVSPEHRRQSTLPTQKCHLQDHYGPFPLVEGERMQVLNGNGGKPRSFTLPRDSGFNHCCQSLSVGATDHHEEVQQKEVEEEEEEEEEEEVKAAEENQEDKIETTEEIAADSLQDLYRALEQASLSPLGDRRISTKLEYRKSFIKRCSDPVVNEKLHQLRILKSTLKAREGEVAIIDKVLDNPGLTSRDFQEWKQIYLDIFLDICHNSTPRGSVNGSSEVDTLLASLAHTHSYIETHV", "length": 1035 }, "evidence": [ { "id": "F1N773", "url": "https://omabrowser.org/oma/group/F1N773/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q80YA9-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "Cnksr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPAHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGAISGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNTPVSACDPQDDIQPPEVEEEEEEEEEEAAGENVGEKNENREEKLGDSLQDLYRALEEASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQSTTSNDPLSISSEVDVLTSSLTHTHSYIETHV", "length": 1032 }, "evidence": [ { "id": "F1N773", "url": "https://omabrowser.org/oma/group/F1N773/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXI2-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "CNKSR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV", "length": 1034 }, "evidence": [ { "id": "F1N773", "url": "https://omabrowser.org/oma/group/F1N773/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1T4-1", "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "Cnksr2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSTSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGAIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDIQPPEVEEEEEEEEEEAAGENIGEKNENREEKLGDSLQDLYRALEEASLSPLGEHRISTKIEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV", "length": 1032 }, "evidence": [ { "id": "F1N773", "url": "https://omabrowser.org/oma/group/F1N773/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" }, { "name": "enzyme-linked receptor protein signaling pathway", "id": "GO:0007167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007167", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" }, { "name": "postsynaptic specialization organization", "id": "GO:0099084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099084", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "F1N773", "url": "https://www.uniprot.org/uniprotkb/F1N773" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1005, "end_pos": 1007, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N773-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1036, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N773-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N773" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N773" }, { "id": "PS51290", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51290" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRIC", "eco_id": "ECO_0000259", "start_pos": 84, "end_pos": 178, "start_aa": "Asn", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N773" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 215, "end_pos": 297, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N773" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 570, "end_pos": 669, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N773", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N773" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 76, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 332 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1005, "end_pos": 1007 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N678-1", "uniprot_ac": "F1N678", "uniprot_id": "F1N678_BOVIN", "mass": { "chemical_mass": 35549.0, "monoisotopic_mass": 35549.0 }, "refseq": {}, "gene_names": [ { "name": "AKR1B10", "type": "recommended", "evidence": [ { "id": "F1N678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ] } ], "protein_names": [ { "name": "Aldo-keto reductase family 1 member B10", "type": "synonym", "evidence": [ { "id": "F1N678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N678/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKR1B10", "url": "https://www.uniprot.org/uniprotkb/F1N678", "locus": { "chromosome": "4", "start_pos": 98239457, "end_pos": 98217455, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001582", "url": "https://www.ensembl.org/id/ENSBTAG00000001582" } ] } } ], "crossref": [ { "id": "F1N678", "url": "https://alphafold.ebi.ac.uk/entry/F1N678", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001582", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001582", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR018170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LWNDSHQ", "url": "https://omabrowser.org/oma/group/LWNDSHQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N678", "url": "https://www.orthodb.org/?gene=F1N678", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11732", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193144", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SMA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N678-1", "url": "https://www.uniprot.org/uniprotkb/F1N678-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSFVELSTKAKVPILGLGTWKSGLGEVREAVKGAIDIGYRHLDCAYAYENEHEVGEAIQEKIQEKAVKREELFIVSKLWPTFMEKHLVRESCQKTLKDLRLDYLDLYLIHFPQALQPGEDLVPKDDKGNTIISKATFLDTWEAMEELVDEGLVKNIGISNFNHFQIERLLNKPGLKYKPVINQIECHPYLTQEKLIQYCQSKGISVTAYSPLGCPNRSGAKPEDPSLLDDPKINEIAAKHKKSTAQVLIRFHIQRHVIVIPKSVTLARIAENFQVFDFKLSEEEMATLLSLDRNWRLKSLEEYPFYAEY", "length": 310, "header": "tr|F1N678-1|F1N678_BOVIN Isoform 1 of Aldo-keto reductase family 1 member B10 OS=Bos taurus OX=9913 GN=AKR1B10 PE=3 SV=2 CANONICAL=F1N678-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA1/entry", "sequence": { "sequence": "MVSFVELSTKAKVPILGLGTWKSGLGEVREAVKGAIDIGYRHLDCAYAYENEHEVGEAIQEKIQEKAVKREELFIVSKLWPTFMEKHLVRESCQKTLKDLRLDYLDLYLIHFPQALQPGEDLVPKDDKGNTIISKATFLDTWEAMEELVDEGLVKNIGISNFNHFQIERLLNKPGLKYKPVINQIECHPYLTQEKLIQYCQSKGISVTAYSPLGCPNRSGAKPEDPSLLDDPKINEIAAKHKKSTAQVLIRFHIQRHVIVIPKSVTLARIAENFQVFDFKLSEEEMATLLSLDRNWRYYTFNS", "length": 303, "header": "tr|A0AAA9SMA1-1|F1N678_BOVIN Computationally mapped isoform of Aldo-keto reductase family 1 member B10 OS=Bos taurus OX=9913 GN=AKR1B10 PE=3 SV=1 CANONICAL=F1N678-1" }, "locus": { "chromosome": "4", "start_pos": 98235097, "end_pos": 98217548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101837.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101837.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086416.1" } ] } }, { "isoform_ac": "F1N678-1", "url": "https://www.uniprot.org/uniprotkb/F1N678/entry", "sequence": { "sequence": "MVSFVELSTKAKVPILGLGTWKSGLGEVREAVKGAIDIGYRHLDCAYAYENEHEVGEAIQEKIQEKAVKREELFIVSKLWPTFMEKHLVRESCQKTLKDLRLDYLDLYLIHFPQALQPGEDLVPKDDKGNTIISKATFLDTWEAMEELVDEGLVKNIGISNFNHFQIERLLNKPGLKYKPVINQIECHPYLTQEKLIQYCQSKGISVTAYSPLGCPNRSGAKPEDPSLLDDPKINEIAAKHKKSTAQVLIRFHIQRHVIVIPKSVTLARIAENFQVFDFKLSEEEMATLLSLDRNWRLKSLEEYPFYAEY", "length": 310, "header": "tr|F1N678-1|F1N678_BOVIN Isoform 1 of Aldo-keto reductase family 1 member B10 OS=Bos taurus OX=9913 GN=AKR1B10 PE=3 SV=2 CANONICAL=F1N678-1" }, "locus": { "chromosome": "4", "start_pos": 98239154, "end_pos": 98217548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002073.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002073.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002073.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002073.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-193144", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193144", "resource": "Reactome", "description": "Estrogen biosynthesis" }, { "id": "R-BTA-975634", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "resource": "Reactome", "description": "Retinoid metabolism and transport" } ], "orthologs": [ { "uniprot_canonical_ac": "C9JRZ8-1", "protein_name": "Aldo-keto reductase family 1 member B15", "gene_name": "AKR1B15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSHLEDFPFDAEY", "length": 316 }, "evidence": [ { "id": "F1N678", "url": "https://omabrowser.org/oma/group/F1N678/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ], "pmid": "" }, { "name": "aldose reductase (NADPH) activity", "id": "GO:0004032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", "evidence": [ { "database": "UniProtKB", "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N678", "url": "https://www.uniprot.org/uniprotkb/F1N678" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N678-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 310, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N678-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N678" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N678" }, { "id": "PF00248", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADP-dependent oxidoreductase", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 292, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N7K2-1", "uniprot_ac": "F1N7K2", "uniprot_id": "F1N7K2_BOVIN", "mass": { "chemical_mass": 206694.0, "monoisotopic_mass": 206694.0 }, "refseq": { "ac": "XP_024851952", "name": "proprotein convertase subtilisin/kexin type 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851952" }, "gene_names": [ { "name": "PCSK5", "type": "recommended", "evidence": [ { "id": "F1N7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ] }, { "name": "PCSK5", "type": "synonym", "evidence": [ { "id": "XP_024851952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851952" } ] } ], "protein_names": [ { "name": "Proprotein convertase subtilisin/kexin type 5", "type": "recommended", "evidence": [ { "id": "F1N7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K2/entry#names_and_taxonomy" } ] }, { "name": "Proprotein convertase 5", "type": "synonym", "evidence": [ { "id": "F1N7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K2/entry#names_and_taxonomy" } ] }, { "name": "Proprotein convertase 6", "type": "synonym", "evidence": [ { "id": "F1N7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K2/entry#names_and_taxonomy" } ] }, { "name": "Subtilisin/kexin-like protease PC5", "type": "synonym", "evidence": [ { "id": "F1N7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K2/entry#names_and_taxonomy" } ] }, { "name": "proprotein convertase subtilisin/kexin type 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024851952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851952" } ] } ], "function": [ { "annotation": "Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MCD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCD7#function" }, { "database": "UniProtKB", "id": "ARBA00053092", "url": "https://www.uniprot.org/uniprotkb/ARBA00053092#function" }, { "database": "UniProtKB", "id": "A0AAA9SPK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK9#function" }, { "database": "UniProtKB", "id": "A0AAA9SZD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD5#function" }, { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCSK5", "url": "https://www.uniprot.org/uniprotkb/F1N7K2", "locus": { "chromosome": "8", "start_pos": 52429365, "end_pos": 51911827, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008101", "url": "https://www.ensembl.org/id/ENSBTAG00000008101" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008101", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008101", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00064", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00064", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528098", "url": "https://www.ncbi.nlm.nih.gov/gene/528098", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528098", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528098", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCD7", "url": "https://www.orthodb.org/?gene=A0A3Q1MCD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7K2", "url": "https://www.orthodb.org/?gene=F1N7K2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00082", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00082", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14843", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14843", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16470", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16470", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-167060", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-167060", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8963889", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963889", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024851952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851952", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7K2-1", "url": "https://www.uniprot.org/uniprotkb/F1N7K2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKISGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERVRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCDSCFGSHGDQCLSCKYGYFLNEETNSCVTHCPDGSYQDTKKSLCRKCSENCKTCTESDNCTECREGLSLQGSRCAITCEDGWYFNGQDCQPCHRSCATCAGAGADGCINCTGGYFMEERRCVQSCSISYYFDPSSENGYKSCKKCDASCLTCNGPGIKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQICEASCIQCRGPTQEDCTGCPVTRVLDDGRCVLNCSLGKFEFRNQCHPCHFTCQECQGDEPSNCTSCGVDKHGQERFLYWGECRESCPPGYYPEEGHTCQPCPDNCELCHSTHVCTRCVRGYFMVPSNHTCQKLECGQGEIQDPDYEECVSCEEGCLGCSLDDPGTCTSCATGYYMFKDHCYKTCPEKTYREEFECKACDTNCGNCDQNECYWCEEGFFLLEGSCVRNCGPGFYGDPEMGDCEPCHQACETCTGLGHNQCSSCREGLQLLQGTCVRHDQTQEEGSFWNDLLRRHQSCHSSCKTCHGSATLCTSCPKGTYLLAQTCVPSCPQGTWPSVRSGSCENCTEDCASCSEVNLCQKCQTRPDRPLFLHQGRCSTRCPEGFYADNDTCEHCSSSCRTCEGNATNCQSCERGLVLDQGVCRETCPERHVAMEGVCKRCPEMCQDCIHEKTCKECMPEFFLHKDACHQSCPSHFYADGRHCVSCHEDCLECSGPWADDCDLCAEASLVLYDGQCLDECPEGTYLEKETKVCKDCQKSCRTCSSSGACTTCQEGLRVNNHGGCVPHTECAAREYWDKEAQACEACHAKCLHCTGPSEFQCQTCLRDSLLLNTTCMQDCPEGYYADEDSHRCAPCHSSCRTCEGRHSMQCLSCQPGWFQLGQECLTQCREGYYAENSTGQCRRCHRSCKACQGPQPTDCLSCDPFFFLLRSKGQCHRTCPEHYYMEPSTQTCERCHPTCDKCKGKGALNCLSCVWSYHLAGGLCTSDCLVGEYRVGEGEKFNCEKCHESCIECKGPGTRNCTVCPANLVLHMDDSRCLRCCSASDPTDAQECCDCHDTEDECILRASTVEPAGERSKTALLITSSIMLVLLLGAAVIVWRKSRSRAKSTGKAGYAKLAEPSVSYSSYKSSHRESFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDNEDDLEYDDESYSYQ", "length": 1857, "header": "tr|F1N7K2-1|F1N7K2_BOVIN Isoform 1 of Proprotein convertase subtilisin/kexin type 5 OS=Bos taurus OX=9913 GN=PCSK5 PE=3 SV=4 CANONICAL=F1N7K2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCD7/entry", "sequence": { "sequence": "MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKISGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERVRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCDSCFGSHGDQCLSCKYGYFLNEETNSCVTHCPDGSYQDTKKSLCRKCSENCKTCTESDNCTECREGLSLQGSRCAITCEDGWYFNGQDCQPCHRSCATCAGAGADGCINCTGGYFMEERRCVQSCSISYYFDPSSENGYKSCKKCDASCLTCNGPGIKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQICEASCIQCRGPTQEDCTGCPVTRVLDDGRCVLNCSLGKFEFRNQCHPCHFTCQECQGDEPSNCTSCGVDKHGQERFLYWGECRESCPPGYYPEEGHTCQPCPDNCELCHSTHVCTRCVRGYFMVPSNHTCQKLECGQGEIQDPDYEECVSCEEGCLGCSLDDPGTCTSCATGYYMFKDHCYKTCPEKTYREEFECKACDTNCGNCDQNECYWCEEGFFLLEGSCVRNCGPGFYGDPEMGDCEPCHQACETCTGLGHNQCSSCREGLQLLQGTCVRHDQTQEEGSFWNVAVSTASPSLVKSLLQDRRRRKVQIKRDLLRRHQSCHSSCKTCHGSATLCTSCPKGTYLLAQTCVPSCPQGTWPSVRSGSCENCTEDCASCSEVNLCQKCQTRPDRPLFLHQGRCSTRCPEGFYADNDTCEHCSSSCRTCEGNATNCQSCERGLVLDQGVCRETCPERHVAMEGVCKRCPEMCQDCIHEKTCKECMPEFFLHKDACHQSCPSHFYADGRHCVSCHEDCLECSGPWADDCDLCAEASLVLYDGQCLDECPEGTYLEKETKVCKDCQKSCRTCSSSGACTTCQEGLRVNNHGGCVPHTECAAREYWDKEAQACEACHAKCLHCTGPSEFQCQTCLRDSLLLNTTCMQDCPEGYYADEDSHRCAPCHSSCRTCEGRHSMQCLSCQPGWFQLGQECLTQCREGYYAENSTGQCRRCHRSCKACQGPQPTDCLSCDPFFFLLRSKGQCHRTCPEHYYMEPSTQTCERCHPTCDKCKGKGALNCLSCVWSYHLAGGLCTSDCLVGEYRVGEGEKFNCEKCHESCIECKGPGTRNCTVCPANLVLHMDDSRCLRCCSASDPTDAQECCDCHDTEDECILRASTVEPAGERSKTALLITSSIMLVLLLGAAVIVWRKSRSRAKSTGKAGYAKLAEPSVSYSSYKSSHRESFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDNEDDLEYDDESYSYQ", "length": 1884, "header": "tr|A0A3Q1MCD7-1|A0A3Q1MCD7_BOVIN Computationally mapped isoform of Proprotein convertase subtilisin/kexin type 5 OS=Bos taurus OX=9913 GN=PCSK5 PE=3 SV=2 CANONICAL=F1N7K2-1" }, "locus": { "chromosome": "8", "start_pos": 52428361, "end_pos": 51912026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077745.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077745.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066434.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066434.2" } ] } }, { "isoform_ac": "A0AAA9SPK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK9/entry", "sequence": { "sequence": "MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKISGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEAKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERVRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCDSCFGSHGDQCLSCKYGYFLNEETNSCVTHCPDGSYQDTKKSLCRKCSENCKTCTESDNCTECREGLSLQGSRCAITCEDGWYFNGQDCQPCHRSCATCAGAGADGCINCTGGYFMEERRCVQSCSISYYFDPSSENGYKSCKKCDASCLTCNGPGIKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQICEASCIQCRGPTQEDCTGCPVTRVLDDGRCVLNCSLGKFEFRNQCHPCHFTCQECQGDEPSNCTSCGVDKHGQERFLYWGECRESCPPGYYPEEGHTCQPCPDNCELCHSTHVCTRCVRGYFMVPSNHTCQKLECGQGEIQDPDYEECVSCEEGCLGCSLDDPGTCTSCATGYYMFKDHCYKTCPEKTYREEFECKACDTNCGNCDQNECYWCEEGFFLLEGSCVRNCGPGFYGDPEMGDCEPCHQACETCTGLGHNQCSSCREGLQLLQGTCVRHDQTQEEGSFWNGTYLLAQTCVPSCPQGTWPSVRSGSCENCTEDCASCSEVNLCQKCQTRPDRPLFLHQGRCSTRCPEGFYADNDTCEHCSSSCRTCEGNATNCQSCERGLVLDQGVCRETCPERHVAMEGVCKRCPEMCQDCIHEKTCKECMPEFFLHKDACHQSCPSHFYADGRHCVSCHEDCLECSGPWADDCDLCAEASLVLYDGQCLDECPEGTYLEKETKVCKDCQKSCRTCSSSGACTTCQEGLRVNNHGGCVPHTECAAREYWDKEAQACEACHAKCLHCTGPSEFQCQTCLRDSLLLNTTCMQDCPEGYYADEDSHRCAPCHSSCRTCEGRHSMQCLSCQPGWFQLGQECLTQCREGYYAENSTGQCRRCHRSCKACQGPQPTDCLSCDPFFFLLRSKGQCHRTCPEHYYMEPSTQTCERCHPTCDKCKGKGALNCLSCVWSYHLAGGLCTSDCLVGEYRVGEGEKFNCEKCHESCIECKGPGTRNCTVCPANLVLHMDDSRCLRCCSASDPTDAQECCDCHDTEDECILRASTVEPAGERSKTALLITSSIMLVLLLGAAVIVWRKSRSRAKSTGKAGYAKLAEPSVSYSSYKSSHRESFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDNEDDLEYDDESYSYQ", "length": 1755, "header": "tr|A0AAA9SPK9-1|F1N7K2_BOVIN Computationally mapped isoform of Proprotein convertase subtilisin/kexin type 5 OS=Bos taurus OX=9913 GN=PCSK5 PE=3 SV=1 CANONICAL=F1N7K2-1" }, "locus": { "chromosome": "8", "start_pos": 52428361, "end_pos": 51912026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089911.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089911.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084853.1" } ] } }, { "isoform_ac": "A0AAA9SZD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD5/entry", "sequence": { "sequence": "MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKISGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERVRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCDSCFGSHGDQCLSCKYGYFLNEETNSCVTHCPDGSYQDTKKSLCRKCSENCKTCTESDNCTECREGLSLQGSRCAITCEDGWYFNGQDCQPCHRSCATCAGAGADGCINCTGGYFMEERRCVQSCSISYYFDPSSENGYKSCKKCDASCLTCNGPGIKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG", "length": 913, "header": "tr|A0AAA9SZD5-1|F1N7K2_BOVIN Computationally mapped isoform of Proprotein convertase subtilisin/kexin type 5 OS=Bos taurus OX=9913 GN=PCSK5 PE=3 SV=1 CANONICAL=F1N7K2-1" }, "locus": { "chromosome": "8", "start_pos": 52274887, "end_pos": 51912026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113700.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113700.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089455.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089455.1" } ] } }, { "isoform_ac": "F1N7K2-1", "url": "https://www.uniprot.org/uniprotkb/F1N7K2/entry", "sequence": { "sequence": "MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKISGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWILEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERVRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCDSCFGSHGDQCLSCKYGYFLNEETNSCVTHCPDGSYQDTKKSLCRKCSENCKTCTESDNCTECREGLSLQGSRCAITCEDGWYFNGQDCQPCHRSCATCAGAGADGCINCTGGYFMEERRCVQSCSISYYFDPSSENGYKSCKKCDASCLTCNGPGIKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQICEASCIQCRGPTQEDCTGCPVTRVLDDGRCVLNCSLGKFEFRNQCHPCHFTCQECQGDEPSNCTSCGVDKHGQERFLYWGECRESCPPGYYPEEGHTCQPCPDNCELCHSTHVCTRCVRGYFMVPSNHTCQKLECGQGEIQDPDYEECVSCEEGCLGCSLDDPGTCTSCATGYYMFKDHCYKTCPEKTYREEFECKACDTNCGNCDQNECYWCEEGFFLLEGSCVRNCGPGFYGDPEMGDCEPCHQACETCTGLGHNQCSSCREGLQLLQGTCVRHDQTQEEGSFWNDLLRRHQSCHSSCKTCHGSATLCTSCPKGTYLLAQTCVPSCPQGTWPSVRSGSCENCTEDCASCSEVNLCQKCQTRPDRPLFLHQGRCSTRCPEGFYADNDTCEHCSSSCRTCEGNATNCQSCERGLVLDQGVCRETCPERHVAMEGVCKRCPEMCQDCIHEKTCKECMPEFFLHKDACHQSCPSHFYADGRHCVSCHEDCLECSGPWADDCDLCAEASLVLYDGQCLDECPEGTYLEKETKVCKDCQKSCRTCSSSGACTTCQEGLRVNNHGGCVPHTECAAREYWDKEAQACEACHAKCLHCTGPSEFQCQTCLRDSLLLNTTCMQDCPEGYYADEDSHRCAPCHSSCRTCEGRHSMQCLSCQPGWFQLGQECLTQCREGYYAENSTGQCRRCHRSCKACQGPQPTDCLSCDPFFFLLRSKGQCHRTCPEHYYMEPSTQTCERCHPTCDKCKGKGALNCLSCVWSYHLAGGLCTSDCLVGEYRVGEGEKFNCEKCHESCIECKGPGTRNCTVCPANLVLHMDDSRCLRCCSASDPTDAQECCDCHDTEDECILRASTVEPAGERSKTALLITSSIMLVLLLGAAVIVWRKSRSRAKSTGKAGYAKLAEPSVSYSSYKSSHRESFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDNEDDLEYDDESYSYQ", "length": 1857, "header": "tr|F1N7K2-1|F1N7K2_BOVIN Isoform 1 of Proprotein convertase subtilisin/kexin type 5 OS=Bos taurus OX=9913 GN=PCSK5 PE=3 SV=4 CANONICAL=F1N7K2-1" }, "locus": { "chromosome": "8", "start_pos": 52428361, "end_pos": 51912026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036658.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036658.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036514.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036514.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1582, "start_aa": "Thr", "end_pos": 1582, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1582", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:528098", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528098", "resource": "KEGG Pathway" }, { "id": "R-BTA-167060", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-167060", "resource": "Reactome", "description": "NGF processing" }, { "id": "R-BTA-8963889", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963889", "resource": "Reactome", "description": "Assembly of active LPL and LIPC lipase complexes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "peptide binding", "id": "GO:0042277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042277", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "viral life cycle", "id": "GO:0019058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019058", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "peptide hormone processing", "id": "GO:0016486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016486", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "embryonic digestive tract development", "id": "GO:0048566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048566", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "embryo implantation", "id": "GO:0007566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007566", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "limb morphogenesis", "id": "GO:0035108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035108", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "respiratory tube development", "id": "GO:0030323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030323", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "peptide biosynthetic process", "id": "GO:0043043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043043", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "embryonic skeletal system development", "id": "GO:0048706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048706", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" }, { "name": "cytokine precursor processing", "id": "GO:0140447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140447", "evidence": [ { "database": "UniProtKB", "id": "F1N7K2", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1014, "end_pos": 1016, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1230, "end_pos": 1232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1274, "end_pos": 1276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1290, "end_pos": 1292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1497, "end_pos": 1499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1561, "end_pos": 1563, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1685, "end_pos": 1687, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 665, "end_pos": 667, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 852, "end_pos": 854, "annotation": "n_glycosylation_sequon" }, { "start_pos": 920, "end_pos": 922, "annotation": "n_glycosylation_sequon" }, { "start_pos": 949, "end_pos": 951, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7K2" }, { "id": "PS51829", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51829" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P/Homo B", "eco_id": "ECO_0000259", "start_pos": 461, "end_pos": 601, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1582 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1014, "end_pos": 1016 }, { "start_pos": 1230, "end_pos": 1232 }, { "start_pos": 1274, "end_pos": 1276 }, { "start_pos": 1290, "end_pos": 1292 }, { "start_pos": 1497, "end_pos": 1499 }, { "start_pos": 1561, "end_pos": 1563 }, { "start_pos": 1685, "end_pos": 1687 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 381, "end_pos": 383 }, { "start_pos": 665, "end_pos": 667 }, { "start_pos": 752, "end_pos": 754 }, { "start_pos": 802, "end_pos": 804 }, { "start_pos": 852, "end_pos": 854 }, { "start_pos": 920, "end_pos": 922 }, { "start_pos": 949, "end_pos": 951 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6PZN1-1", "uniprot_ac": "F6PZN1", "uniprot_id": "F6PZN1_BOVIN", "mass": { "chemical_mass": 39099.0, "monoisotopic_mass": 39099.0 }, "refseq": {}, "gene_names": [ { "name": "CBX7", "type": "recommended", "evidence": [ { "id": "F6PZN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ] } ], "protein_names": [ { "name": "Chromobox 7", "type": "synonym", "evidence": [ { "id": "F6PZN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZN1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CBX7", "url": "https://www.uniprot.org/uniprotkb/F6PZN1", "locus": { "chromosome": "5", "start_pos": 110591239, "end_pos": 110609223, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007228", "url": "https://www.ensembl.org/id/ENSBTAG00000007228" } ] } } ], "crossref": [ { "id": "F6PZN1", "url": "https://alphafold.ebi.ac.uk/entry/F6PZN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007228", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007228", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18646", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18646", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PHKAHKY", "url": "https://omabrowser.org/oma/group/PHKAHKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6PZN1", "url": "https://www.orthodb.org/?gene=F6PZN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47277", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47277", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47277:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47277:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00385", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00385", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17218", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17218", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZN1-1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGRGRLDESRAPAPPRPAPPSPPPGALARGLARAEENVAQVQKWNVGGVREREGVCARARARARPGEGDGDPAGPSIARRSRGPAAPPPARPGPGPARPPPRMELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTRPLGSGSPKGVVKAGAPELADKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQESPAQDVLQAASEWEPAEQPPEEEAEADLGEGPPSWTPTLPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 354, "header": "tr|F6PZN1-1|F6PZN1_BOVIN Isoform 1 of Chromobox 7 OS=Bos taurus OX=9913 GN=CBX7 PE=4 SV=2 CANONICAL=F6PZN1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPP6/entry", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKRYRQWEPVFPTRFVQMPNWRGVLGRASHAEGLVRHSPQLPWAHSREERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTRPLGSGSPKGVVKAGAPELADKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQESPAQDVLQAASEWEPAEQPPEEEAEADLGEGPPSWTPTLPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 296, "header": "tr|A0AAA9SPP6-1|F6PZN1_BOVIN Computationally mapped isoform of Chromobox 7 OS=Bos taurus OX=9913 GN=CBX7 PE=4 SV=1 CANONICAL=F6PZN1-1" }, "locus": { "chromosome": "5", "start_pos": 110608858, "end_pos": 110592243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094291.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094291.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085907.1" } ] } }, { "isoform_ac": "F6PZN1-1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1/entry", "sequence": { "sequence": "MEGRGRLDESRAPAPPRPAPPSPPPGALARGLARAEENVAQVQKWNVGGVREREGVCARARARARPGEGDGDPAGPSIARRSRGPAAPPPARPGPGPARPPPRMELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTRPLGSGSPKGVVKAGAPELADKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQESPAQDVLQAASEWEPAEQPPEEEAEADLGEGPPSWTPTLPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 354, "header": "tr|F6PZN1-1|F6PZN1_BOVIN Isoform 1 of Chromobox 7 OS=Bos taurus OX=9913 GN=CBX7 PE=4 SV=2 CANONICAL=F6PZN1-1" }, "locus": { "chromosome": "5", "start_pos": 110609167, "end_pos": 110592243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009507.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009507.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009507.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009507.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SNY1-1", "protein_name": "Chromobox 7", "gene_name": "CBX7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLARPLGSGSPEGVVKAGAPELADKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQESPAPDVLQAASEWEPAEQPPEEEADADLAEGPPSWTPTLPSSEVTVTDITANSITVTFREAQAAEGFFRDRGGKF", "length": 251 }, "evidence": [ { "id": "F6PZN1", "url": "https://omabrowser.org/oma/group/F6PZN1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95931-1", "protein_name": "Chromobox protein homolog 7", "gene_name": "CBX7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 251 }, "evidence": [ { "id": "F6PZN1", "url": "https://omabrowser.org/oma/group/F6PZN1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P60889-1", "protein_name": "Chromobox protein homolog 7", "gene_name": "Cbx7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLLLQESAAPDVLQATGDWEPVEQPPEEEAEADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRSGKL", "length": 158 }, "evidence": [ { "id": "F6PZN1", "url": "https://omabrowser.org/oma/group/F6PZN1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VDS3-1", "protein_name": "Chromobox protein homolog 7", "gene_name": "Cbx7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPRRLLLQESAAPDVVQTPGDWEPMEQAPEEEAEADLTNGPPPWTPTLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRNEKL", "length": 158 }, "evidence": [ { "id": "F6PZN1", "url": "https://omabrowser.org/oma/group/F6PZN1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "PRC1 complex", "id": "GO:0035102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035102", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" }, { "name": "PcG protein complex", "id": "GO:0031519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031519", "evidence": [ { "database": "UniProtKB", "id": "F6PZN1", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6PZN1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 354, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6PZN1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6PZN1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6PZN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PZN1" }, { "id": "PS50013", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chromo", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 172, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N270-1", "uniprot_ac": "F1N270", "uniprot_id": "F1N270_BOVIN", "mass": { "chemical_mass": 28249.0, "monoisotopic_mass": 28249.0 }, "refseq": { "ac": "NP_001068609", "name": "V-type proton ATPase subunit D isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" }, "gene_names": [ { "name": "ATP6V1D", "type": "recommended", "evidence": [ { "id": "F1N270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ] }, { "name": "ATP6V1D", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] }, { "name": "VATD", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] } ], "protein_names": [ { "name": "V-type proton ATPase subunit D", "type": "recommended", "evidence": [ { "id": "F1N270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N270/entry#names_and_taxonomy" } ] }, { "name": "V-ATPase 28 kDa accessory protein", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] }, { "name": "V-ATPase subunit D", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] }, { "name": "V-type proton ATPase subunit D isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] }, { "name": "V-type proton ATPase subunit D", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] }, { "name": "V-type proton ATPase subunit d", "type": "synonym", "evidence": [ { "id": "F1N270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N270/entry#names_and_taxonomy" } ] }, { "name": "Vacuolar proton pump subunit D", "type": "synonym", "evidence": [ { "id": "F1N270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N270/entry#names_and_taxonomy" } ] }, { "name": "vacuolar H-ATPase subunit D", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] }, { "name": "vacuolar proton pump subunit D", "type": "synonym", "evidence": [ { "id": "NP_001068609", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609" } ] } ], "function": [ { "annotation": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270#function" }, { "database": "UniProtKB", "id": "ARBA00045802", "url": "https://www.uniprot.org/uniprotkb/ARBA00045802#function" }, { "database": "UniProtKB", "id": "A0AAA9TPW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW3#function" }, { "database": "UniProtKB", "id": "A0AAA9SQW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATP6V1D", "url": "https://www.uniprot.org/uniprotkb/F1N270", "locus": { "chromosome": "10", "start_pos": 79239423, "end_pos": 79255202, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016309", "url": "https://www.ensembl.org/id/ENSBTAG00000016309" } ] } } ], "crossref": [ { "id": "F1N270", "url": "https://alphafold.ebi.ac.uk/entry/F1N270", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016309", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016309", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404152", "url": "https://www.ncbi.nlm.nih.gov/gene/404152", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404152", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404152", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "REEFFRM", "url": "https://omabrowser.org/oma/group/REEFFRM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N270", "url": "https://www.orthodb.org/?gene=F1N270", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11671", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11671", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01813", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01813", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068609", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N270-1", "url": "https://www.uniprot.org/uniprotkb/F1N270-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSDKDLEQRRAAGEVIEPANLLAEEKDEDLLFE", "length": 247, "header": "tr|F1N270-1|F1N270_BOVIN Isoform 1 of V-type proton ATPase subunit D OS=Bos taurus OX=9913 GN=ATP6V1D PE=3 SV=3 CANONICAL=F1N270-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW0/entry", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSDKDLEQRRAAGEVIEPANLLAEEKDEDLLFE", "length": 148, "header": "tr|A0AAA9SQW0-1|F1N270_BOVIN Computationally mapped isoform of V-type proton ATPase subunit D OS=Bos taurus OX=9913 GN=ATP6V1D PE=3 SV=1 CANONICAL=F1N270-1" }, "locus": { "chromosome": "10", "start_pos": 79255065, "end_pos": 79239968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122466.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122466.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086348.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086348.1" } ] } }, { "isoform_ac": "A0AAA9TPW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPW3/entry", "sequence": { "sequence": "CSSKEAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSDKDLEQRRAAGEVIEPANLLAEEKDEDLLFE", "length": 238, "header": "tr|A0AAA9TPW3-1|F1N270_BOVIN Computationally mapped isoform of V-type proton ATPase subunit D OS=Bos taurus OX=9913 GN=ATP6V1D PE=3 SV=2 CANONICAL=F1N270-1" }, "locus": { "chromosome": "10", "start_pos": 79251861, "end_pos": 79239968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131006.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131006.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098412.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098412.2" } ] } }, { "isoform_ac": "F1N270-1", "url": "https://www.uniprot.org/uniprotkb/F1N270/entry", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSDKDLEQRRAAGEVIEPANLLAEEKDEDLLFE", "length": 247, "header": "tr|F1N270-1|F1N270_BOVIN Isoform 1 of V-type proton ATPase subunit D OS=Bos taurus OX=9913 GN=ATP6V1D PE=3 SV=3 CANONICAL=F1N270-1" }, "locus": { "chromosome": "10", "start_pos": 79255065, "end_pos": 79239968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021699.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021699.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021699.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021699.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404152", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404152", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZJL5-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEAMEPANLLAEEKDEDLLFE", "length": 247 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7HJ17-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "Atp6v1d", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKFEKELEYRRAAGEVMEPANLLAEEKDEDLLFE", "length": 247 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F7EUL0-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "Atp6v1d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKSEKDLERRRAAGEVMEPANLLAEEKDEDLLFE", "length": 247 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P32610-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "VMA8", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSGNREQVFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRFRDITKRIDDAKQKMGRVMQTAAFSLAEVSYATGENIGYQVQESVSTARFKVRARQENVSGVYLSQFESYIDPEINDFRLTGLGRGGQQVQRAKEIYSRAVETLVELASLQTAFIILDEVIKVTNRRVNAIEHVIIPRTENTIAYINSELDELDREEFYRLKKVQEKKQNETAKLDAEMKLKRDRAEQDASEVAADEEPQGETLVADQEDDVIF", "length": 256 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P57746-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "Atp6v1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKFEKDLERRRAAGEVMEPANLLAEEKDEDLLFE", "length": 247 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86A77-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "atp6v1d", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSGKNRLNIFPTRMALTVMKTKLKGAVTGHSLLKKKSDALTIRFRRILANIVENKQLMGTTMRDASFSLAAAKYAAGEFSNSVIENVSNPTIAVKMTTENVAGVHLPTFEKISEGVVSNSQELTGLSKGGQQINKSRESHIKAVEALIALASLQTAFITLDEVIKITNRRVNAIEYVVKPKLENTISYIITELDESEREEFYRLKKVQGKKKKDLKAKEAQKEENSANKTIMEPASVHKVRSLIDDEPEDAELLYED", "length": 257 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9V7D2-1", "protein_name": "V-type proton ATPase subunit D 1", "gene_name": "Vha36-1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSGKDRLPIFPSRGAQMLMKARLAGAQKGHGLLKKKADALQMRFRLILGKIIETKTLMGDVMKEAAFSLAEAKFTSGDINQVVLQNVTKAQIKIRTKKDNVAGVTLPVFESYQDGSDTYELAGLARGGQQLAKLKKNYQSAVKLLVELASLQTSFVTLDEVIKITNRRVNAIEHVIIPRIDRTLAYIISELDELEREEFYRLKKIQDKKREARIKADAKKAELLQQGIDVRQQANILDEGDDDVLF", "length": 246 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9XGM1-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "VHA-D", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGQNARLNVVPTVTMLGVMKARLVGATRGHALLKKKSDALTVQFRALLKKIVTAKESMGDMMKTSSFALTEVKYVAGDNVKHVVLENVKEATLKVRSRTENIAGVKLPKFDHFSEGETKNDLTGLARGGQQVRACRVAYVKAIEVLVELASLQTSFLTLDEAIKTTNRRVNALENVVKPKLENTISYIKGELDELEREDFFRLKKIQGYKRREVERQAANAKEFAEEMVLEDISMQRGISINAARNFLVGGAEKDSDIIF", "length": 261 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE", "length": 247 }, "evidence": [ { "id": "F1N270", "url": "https://omabrowser.org/oma/group/F1N270/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "clathrin-coated vesicle membrane", "id": "GO:0030665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030665", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "proton-transporting V-type ATPase complex", "id": "GO:0033176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033176", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "proton-transporting ATPase activity, rotational mechanism", "id": "GO:0046961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046961", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" }, { "name": "synaptic vesicle lumen acidification", "id": "GO:0097401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097401", "evidence": [ { "database": "UniProtKB", "id": "F1N270", "url": "https://www.uniprot.org/uniprotkb/F1N270" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N270-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 247, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N270-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N270" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1S8-1", "uniprot_ac": "F1N1S8", "uniprot_id": "F1N1S8_BOVIN", "mass": { "chemical_mass": 69774.0, "monoisotopic_mass": 69774.0 }, "refseq": { "ac": "NP_001193287", "name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193287" }, "gene_names": [ { "name": "PPP2R5D", "type": "recommended", "evidence": [ { "id": "F1N1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ] }, { "name": "PPP2R5D", "type": "synonym", "evidence": [ { "id": "NP_001193287", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193287" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit", "type": "recommended", "evidence": [ { "id": "F1N1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1S8/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "type": "synonym", "evidence": [ { "id": "NP_001193287", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193287" } ] } ], "function": [ { "annotation": "The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST11#function" }, { "database": "UniProtKB", "id": "PIRNR028043", "url": "https://www.uniprot.org/uniprotkb/PIRNR028043#function" }, { "database": "UniProtKB", "id": "A0AAA9SU24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU24#function" }, { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP2R5D", "url": "https://www.uniprot.org/uniprotkb/F1N1S8", "locus": { "chromosome": "23", "start_pos": 16653065, "end_pos": 16629734, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005533", "url": "https://www.ensembl.org/id/ENSBTAG00000005533" } ] } } ], "crossref": [ { "id": "F1N1S8", "url": "https://alphafold.ebi.ac.uk/entry/F1N1S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005533", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005533", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100134966", "url": "https://www.ncbi.nlm.nih.gov/gene/100134966", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100134966", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100134966", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECSHEYT", "url": "https://omabrowser.org/oma/group/ECSHEYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1S8", "url": "https://www.orthodb.org/?gene=F1N1S8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10257", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10257", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10257:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10257:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-180024", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-180024", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-195253", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-196299", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196299", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-198753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202670", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202670", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389513", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432142", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432142", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673000", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5675221", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675221", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193287", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9ST11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1S8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPYKLKKEKEPPKLAKGTAKPSSSSKDGGGESTEEAQPQPQPQPQPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 600, "header": "tr|F1N1S8-1|F1N1S8_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit OS=Bos taurus OX=9913 GN=PPP2R5D PE=3 SV=2 CANONICAL=F1N1S8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST11/entry", "sequence": { "sequence": "MPYKLKKEKELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 496, "header": "tr|A0AAA9ST11-1|F1N1S8_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit OS=Bos taurus OX=9913 GN=PPP2R5D PE=3 SV=1 CANONICAL=F1N1S8-1" }, "locus": { "chromosome": "23", "start_pos": 16652006, "end_pos": 16629865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090774.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090774.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089551.1" } ] } }, { "isoform_ac": "A0AAA9SU24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU24/entry", "sequence": { "sequence": "MPYKLKKEKAQPQPQPQPQPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 574, "header": "tr|A0AAA9SU24-1|F1N1S8_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit OS=Bos taurus OX=9913 GN=PPP2R5D PE=3 SV=1 CANONICAL=F1N1S8-1" }, "locus": { "chromosome": "23", "start_pos": 16652006, "end_pos": 16629865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097129.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097129.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089917.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089917.1" } ] } }, { "isoform_ac": "F1N1S8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1S8/entry", "sequence": { "sequence": "MPYKLKKEKEPPKLAKGTAKPSSSSKDGGGESTEEAQPQPQPQPQPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 600, "header": "tr|F1N1S8-1|F1N1S8_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit OS=Bos taurus OX=9913 GN=PPP2R5D PE=3 SV=2 CANONICAL=F1N1S8-1" }, "locus": { "chromosome": "23", "start_pos": 16652006, "end_pos": 16629865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007277.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007277.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007277.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007277.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100134966", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100134966", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-180024", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-180024", "resource": "Reactome", "description": "DARPP-32 events" }, { "id": "R-BTA-195253", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-BTA-196299", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196299", "resource": "Reactome", "description": "Beta-catenin phosphorylation cascade" }, { "id": "R-BTA-198753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198753", "resource": "Reactome", "description": "ERK/MAPK targets" }, { "id": "R-BTA-202670", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202670", "resource": "Reactome", "description": "ERKs are inactivated" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-389356", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389356", "resource": "Reactome", "description": "Co-stimulation by CD28" }, { "id": "R-BTA-389513", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389513", "resource": "Reactome", "description": "Co-inhibition by CTLA4" }, { "id": "R-BTA-432142", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432142", "resource": "Reactome", "description": "Platelet sensitization by LDL" }, { "id": "R-BTA-4641262", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "resource": "Reactome", "description": "Disassembly of the destruction complex and recruitment of AXIN to the membrane" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-5673000", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673000", "resource": "Reactome", "description": "RAF activation" }, { "id": "R-BTA-5675221", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675221", "resource": "Reactome", "description": "Negative regulation of MAPK pathway" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LXC9-1", "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit", "gene_name": "Ppp2r5d", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPYKLKKDKEPPKLAKGTAKPSSSSKDGGGENADEVQPQPQPQTPSSNKRPSNSTPPQTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 594 }, "evidence": [ { "id": "F1N1S8", "url": "https://omabrowser.org/oma/group/F1N1S8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6A6K6-1", "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit", "gene_name": "Ppp2r5d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRKKGSCLAPMTNPRRRRLVVRQVCKSSGQLEAQPPLGPGAARRRWRRDAERAECGRAEPEPERGRRSRAGCGPAEMPYKLKKDKEPPKLAKGTAKPSSSSKDGGGENTDTEAQPQPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKDKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 671 }, "evidence": [ { "id": "F1N1S8", "url": "https://omabrowser.org/oma/group/F1N1S8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A5GFQ9-1", "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit", "gene_name": "PPP2R5D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPYKLKKEKEPPKLAKSTAKPSSSSKDGAGESAEEAQPQPQPQPQPPPQPQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 602 }, "evidence": [ { "id": "F1N1S8", "url": "https://omabrowser.org/oma/group/F1N1S8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14738-1", "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "gene_name": "PPP2R5D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL", "length": 602 }, "evidence": [ { "id": "F1N1S8", "url": "https://omabrowser.org/oma/group/F1N1S8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54VB6-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit psrA", "gene_name": "psrA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKNDHINYQQNLSQSPILNSNKNQTQQNQQQQQQQQQQNPQQQQQFQHQQVPQLSPQQIPFSEPLKNNLTLQHQQQQQQHQQLAGGQHGSLLRKSYSSRFHEKPQGELTKIANFQDVSPEERPSLFLLKLKQCCYVYDFSDNTYMVSKGVKQEALLQCVNFLSTNDQPLHESIYKMVFEMVAVNLFRPLPPRINPYGVMYDPEEDEPILEAAWPHIQVVYEVLLRFIDSPTFNTHIAKNYVDDRFVLQMLDLFDSEDPRERDYLKTTLHRIYGKFLGLRGFIRTAIRNLFCTFVYESHQHNGISEILEVLGSIINGFLVPLKDEHKQFLIKVLIPLHKPKSYSVYCSHLGYCMSQFIEKEPSLAEPIFKSILRLWPCGNSQKEVLFLSEMEDLLGLVSDEQFAKFRNQFFRQMTKCFQSEHFQVAERALYLFSNENIVLLIASKNNFTLALETFYKPLHENSISHWNRSIRNLSISSLKLFMEIDMDLFNKISEKYKESKKKQQQIQQREKFKQNAPETQKSKQINQNNNNNNNNINNNNNNNNNNNGSTETKADKPSMIRRKSLLPVDPSTIAALSSHRSLEDIMSTNSNSGNDDDDENNHTNHDSEIENEVKEDFRVPVNNRYTFT", "length": 628 }, "evidence": [ { "id": "F1N1S8", "url": "https://omabrowser.org/oma/group/F1N1S8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8IN89-1", "protein_name": "Well-rounded, isoform B", "gene_name": "wrd", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVFGAMLLTGNGLKGPKQQQQQHQQEPQQQQQQSQQQQQEQKKPAPIKSSSKEQETQPIAAGYYALGIRIPKSPSFHSGLDQLADDELDDQVQDQQQEQQQTGSRFRFSSVEELKAKFEGRKTPLSPPEAAAGGAAGSGAPTTSSSPSSSSTSSNSSASALSSLSQAASSSLASAAANSSASSSAATYGGGANSAAAALIASSPFGSQSSTSSLSLSSNAGMSKNAAGAGSGSGSGTTSTGAASGSNSLVSTLAQHFSAATSAAASAAAAAASSASAASSSSASSSSTATNNAASSSIAASKSPVSAAAAIKNILNATKSVGTSAAAAAAAAATSSSSSPSSAAAVPSSAATAVAAVPTTSDVPAEEMRPTVAQNLVGGISISLGIGQRNGGAAPASSAVMVTPNATMVVTTSSLSIRQNGDILPGHPAGLQPSPQTLQQLTGSPGRARDRNLFYTPPTASVAMALPALRETAASEREELFIQKIQQCCTLFDFSEPLSDLKFKEVKRAALHEMVDFLTNQNGVITEVIYPEAINMFAVNLFRTLPPSSNPNGAEFDPEEDEPTLESSWPHLQLVYELFLRFLESPDFQPSMAKRFIDHQFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKQFLLKVLLPLHKAKSLSVYHPQLTYCVVQFLEKDPSLSEAVIKSLLKFWPKTHSPKEVMFLNELEELLDVIEPAEFQKVMVPLFRQIAKCVSSPHFQVAERALYYWNNEYIMSLITDNSAVILPIMFPALNRNSKTHWNKTIHGLIYNALKLFMEIDQRLFDECSKNYKQEKQMEREKLSQREELWQQVESLAKTNPEWTKARRFNDCLPVSDSRALCDQYSENSDSAYDQSEQRARQPPPPLPPQKQAHQEPREIRGERNKDKPLLRRKSDLPSDSGTVKALNEHKRTDEYLTTPPPDGNY", "length": 984 }, "evidence": [ { "id": "F1N1S8", "url": "https://omabrowser.org/oma/group/F1N1S8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" }, { "name": "protein phosphatase type 2A complex", "id": "GO:0000159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000159", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" }, { "name": "meiotic sister chromatid cohesion", "id": "GO:0051177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051177", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" }, { "name": "protein phosphatase activator activity", "id": "GO:0072542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072542", "evidence": [ { "database": "UniProtKB", "id": "F1N1S8", "url": "https://www.uniprot.org/uniprotkb/F1N1S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1S8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 600, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1S8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1S8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 457, "end_pos": 459 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N401-1", "uniprot_ac": "F1N401", "uniprot_id": "F1N401_BOVIN", "mass": { "chemical_mass": 333001.0, "monoisotopic_mass": 333001.0 }, "refseq": { "ac": "NP_001193426", "name": "collagen alpha-1(XII) chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193426" }, "gene_names": [ { "name": "COL12A1", "type": "recommended", "evidence": [ { "id": "F1N401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N401" } ] }, { "name": "COL12A1", "type": "synonym", "evidence": [ { "id": "NP_001193426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193426" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(XII) chain", "type": "recommended", "evidence": [ { "id": "F1N401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N401/entry#names_and_taxonomy" } ] }, { "name": "Collagen alpha-1(XII) chain", "type": "synonym", "evidence": [ { "id": "NP_001193426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193426" } ] }, { "name": "collagen alpha-1(XII) chain precursor", "type": "synonym", "evidence": [ { "id": "NP_001193426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193426" } ] }, { "name": "collagen, type XII, alpha 1", "type": "synonym", "evidence": [ { "id": "NP_001193426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193426" } ] } ], "function": [ { "annotation": "Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.", "evidence": [ { "database": "UniProtKB", "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401#function" }, { "database": "UniProtKB", "id": "ARBA00053577", "url": "https://www.uniprot.org/uniprotkb/ARBA00053577#function" }, { "database": "UniProtKB", "id": "A0AAA9SVH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH3#function" }, { "database": "UniProtKB", "id": "A0AAA9T7G8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL12A1", "url": "https://www.uniprot.org/uniprotkb/F1N401", "locus": { "chromosome": "9", "start_pos": 14661265, "end_pos": 14779709, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020056", "url": "https://www.ensembl.org/id/ENSBTAG00000020056" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020056", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020056", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01482", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01482", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "359712", "url": "https://www.ncbi.nlm.nih.gov/gene/359712", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F1N401", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1N401*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:359712", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:359712", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIIRYKT", "url": "https://omabrowser.org/oma/group/YIIRYKT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193426", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7G8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N401-1", "url": "https://www.uniprot.org/uniprotkb/F1N401-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRIRLPPALAALGAALLLSSIEAEVEPPSDLNFKIIDENTVHMSWAIPPDPIVGFKITVDPTTDGPTKEFTLSASTTETLLTELIPEIEYVVTITSYDEVEESVPVIGQLTIQTGGPTKPGEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQQEELLAAIKKIPYKGGNTMTGEAIDYLIKNTFTESAGARVGFPKVAIIITDGKSQDEVEIPARELRNIGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIATEVSSKYVKLSWSPSPSAVTGYKVLLIPMTTGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGLTSSEPVSIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDINFSEVTSNSLKTSWSPAGENVFSYHITYKEATGDDQVTLVEPASSTSVVLSNLKPETLYLVNVTAEYEDGFSIPLAGEETTAEVKGAPRNLKVTDETTDSFKITWTQAPGRVLRYRITYRPVAGGESKEVTTPANQRRRTLENLTPDTKYEVSVIPEYVSGPGSPLTGNAATEEVRGNPRDLRVSDPTTSTMKLSWTRAPGKVKQYLITYTPVAGGDTQEVTVKGDTASTVLRGLNEGTQYALSVTALYASGAGDALFGEGTTLEERGSPGDLITKDITDTSIGAYWTSAPGMVRGYRVSWQSLYDDIETGEKSLPADVIHTVIENLQPETKYRVSIFATYSSGEGEPLSGEAMTELSEDSKTLKVDEETENTMRVTWKPAPGKVVNYRVMYRPRGGGRQMVAKVSPTVTSTVLKRLQPQTTYDITVLPVYKTGEGKLRQGSGTTASRFKSPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVVGPYDNTVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHKDKKSLLQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDIHAYNVADFDSLSRIVDDLTNNLCNSVKGPGDLEAPSNLVLSERTHRSMRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLERSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDIGSTTMHVQWQPVGGATGYTVTYEPINATVPTKPKEMRLEPTVNDVQLSDLFPNTEYAVTVQAVLHDLTSEPVTAREVTLPLPSPRDLKLRDVTHSTMNVAWEPAPGKVRKYIVRYKTPEEEAKEVEVDRSRASTPLKDLFSQTLYTVSVSAVYEEGESPPVTAQETTHTVPAPTNLQITEVTPESFRGTWDHGASDVSLYRITWAPSGSADKMETILNGDENTLVFQNLNPNTLYEVSVTAIYPDESESDDLIGSERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVLLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSSLNVRWDHAEGSPRQYKLFYAPTAGGPEELVPIPGNTNYAILRNLQPDTQYTVTVVPVYSEGDGGRTSDTGRTLVRGLARNVQVYNPTPNSLDVRWDSAPGPVQQYRIVYSPQDGTRPSESIVVPGNTYTVHLEQLIPDTPYSVNIVALYSDAEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIPVYEDGDGTHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEVFVGEVTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQVGWDTFCVRWLAHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTDLSPETDYGVTVFVQTPNLEGPGVSVKERTTLKPTEAPTEPPTPPPPPTIPPAREVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFHTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSSYRLQKNAFVNQPTVELHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKALFYGSFHKVHIVVTSKSVKIYIDCYEIVEKDIKEAGNITTDGYEILGKLLKGERKSATFQIQNFDIVCSPVWTSRDRCCDIPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGVSGAVGPPGPRGDTGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGPSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMNRFNQMLNQIPNDYHSSRNQPGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPQGERGLPGEKGERGIGSPGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPGSG", "length": 3065, "header": "tr|F1N401-1|F1N401_BOVIN Isoform 1 of Collagen alpha-1(XII) chain OS=Bos taurus OX=9913 GN=COL12A1 PE=3 SV=3 CANONICAL=F1N401-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH3/entry", "sequence": { "sequence": "MRIRLPPALAALGAALLLSSIEAEGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHKDKKSLLQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDIHAYNVADFDSLSRIVDDLTNNLCNSVKGPGDLEAPSNLVLSERTHRSMRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLERSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDIGSTTMHVQWQPVGGATGYTVTYEPINATVPTKPKEMRLEPTVNDVQLSDLFPNTEYAVTVQAVLHDLTSEPVTAREVTLPLPSPRDLKLRDVTHSTMNVAWEPAPGKVRKYIVRYKTPEEEAKEVEVDRSRASTPLKDLFSQTLYTVSVSAVYEEGESPPVTAQETTHTVPAPTNLQITEVTPESFRGTWDHGASDVSLYRITWAPSGSADKMETILNGDENTLVFQNLNPNTLYEVSVTAIYPDESESDDLIGSERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVLLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSSLNVRWDHAEGSPRQYKLFYAPTAGGPEELVPIPGNTNYAILRNLQPDTQYTVTVVPVYSEGDGGRTSDTGRTLVRGLARNVQVYNPTPNSLDVRWDSAPGPVQQYRIVYSPQDGTRPSESIVVPGNTYTVHLEQLIPDTPYSVNIVALYSDAEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIPVYEDGDGTHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEVFVGEVTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQVGWDTFCVRWLAHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTDLSPETDYGVTVFVQTPNLEGPGVSVKERTTLKPTEAPTEPPTPPPPPTIPPAREVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFHTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSSYRLQKNAFVNQPTVELHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKALFYGSFHKVHIVVTSKSVKIYIDCYEIVEKDIKEAGNITTDGYEILGKLLKGERKSATFQIQNFDIVCSPVWTSRDRCCDIPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGVSGAVGPPGPRGDTGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGPSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMNRFNQMLNQIPNDYHSSRNQPGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPQGERGLPGEKGERGIGSPGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPGSG", "length": 1901, "header": "tr|A0AAA9SVH3-1|F1N401_BOVIN Computationally mapped isoform of Collagen alpha-1(XII) chain OS=Bos taurus OX=9913 GN=COL12A1 PE=3 SV=1 CANONICAL=F1N401-1" }, "locus": { "chromosome": "9", "start_pos": 14776366, "end_pos": 14663445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110709.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110709.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089321.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089321.1" } ] } }, { "isoform_ac": "A0AAA9T7G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G8/entry", "sequence": { "sequence": "MRIRLPPALAALGAALLLSSIEAEVEPPSDLNFKIIDENTVHMSWAIPPDPIVGFKITVDPTTDGPTKEFTLSASTTETLLTELIPEIEYVVTITSYDEVEESVPVIGQLTIQTGGPTKPGEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQQEELLAAIKKIPYKGGNTMTGEAIDYLIKNTFTESAGARVGFPKVAIIITDGKSQDEVEIPARELRNIGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIATEVSSKYVKLSWSPSPSAVTGYKVLLIPMTTGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGLTSSEPVSIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDINFSEVTSNSLKTSWSPAGENVFSYHITYKEATGDDQVTLVEPASSTSVVLSNLKPETLYLVNVTAEYEDGFSIPLAGEETTAEVKGAPRNLKVTDETTDSFKITWTQAPGRVLRYRITYRPVAGGESKEVTTPANQRRRTLENLTPDTKYEVSVIPEYVSGPGSPLTGNAATEEVRGNPRDLRVSDPTTSTMKLSWTRAPGKVKQYLITYTPVAGGDTQEVTVKGDTASTVLRGLNEGTQYALSVTALYASGAGDALFGEGTTLEERGSPGDLITKDITDTSIGAYWTSAPGMVRGYRVSWQSLYDDIETGEKSLPADVIHTVIENLQPETKYRVSIFATYSSGEGEPLSGEAMTELSEDSKTLKVDEETENTMRVTWKPAPGKVVNYRVMYRPRGGGRQMVAKVSPTVTSTVLKRLQPQTTYDITVLPVYKTGEGKLRQGSGTTASRFKSPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVVGPYDNTVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHKDKKSLLQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDIHAYNVADFDSLSRIVDDLTNNLCNSVKGPGDLEAPSNLVLSERTHRSMRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLERSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDIGSTTMHVQWQPVGGATGYTVTYEPINATVPTKPKEMRLEPTVNDVQLSDLFPNTEYAVTVQAVLHDLTSEPVTAREVTLPLPSPRDLKLRDVTHSTMNVAWEPAPGKVRKYIVRYKTPEEEAKEVEVDRSRASTPLKDLFSQTLYTVSVSAVYEEGESPPVTAQETTHTVPAPTNLQITEVTPESFRGTWDHGASDVSLYRITWAPSGSADKMETILNGDENTLVFQNLNPNTLYEVSVTAIYPDESESDDLIGSERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVLLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSSLNVRWDHAEGSPRQYKLFYAPTAGGPEELVPIPGNTNYAILRNLQPDTQYTVTVVPVYSEGDGGRTSDTGRTLVRGLARNVQVYNPTPNSLDVRWDSAPGPVQQYRIVYSPQDGTRPSESIVVPGNTYTVHLEQLIPDTPYSVNIVALYSDAEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIPVYEDGDGTHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEVFVGEVTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQVGWDTFCVRWLAHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTDLSPETDYGVTVFVQTPNLEGPGVSVKERTTLKPTEAPTEPPTPPPPPTIPPAREVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFHTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSSYRLQKNAFVNQPTVELHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKALFYGSFHKRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGVSGAVGPPGPRGDTGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGPSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMNRFNQMLNQIPNDYHSSRNQPGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPQGERGLPGEKGERGIGSPGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPGSG", "length": 2989, "header": "tr|A0AAA9T7G8-1|F1N401_BOVIN Computationally mapped isoform of Collagen alpha-1(XII) chain OS=Bos taurus OX=9913 GN=COL12A1 PE=3 SV=1 CANONICAL=F1N401-1" }, "locus": { "chromosome": "9", "start_pos": 14776366, "end_pos": 14663445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128312.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128312.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092547.1" } ] } }, { "isoform_ac": "F1N401-1", "url": "https://www.uniprot.org/uniprotkb/F1N401/entry", "sequence": { "sequence": "MRIRLPPALAALGAALLLSSIEAEVEPPSDLNFKIIDENTVHMSWAIPPDPIVGFKITVDPTTDGPTKEFTLSASTTETLLTELIPEIEYVVTITSYDEVEESVPVIGQLTIQTGGPTKPGEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQQEELLAAIKKIPYKGGNTMTGEAIDYLIKNTFTESAGARVGFPKVAIIITDGKSQDEVEIPARELRNIGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIATEVSSKYVKLSWSPSPSAVTGYKVLLIPMTTGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGLTSSEPVSIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDINFSEVTSNSLKTSWSPAGENVFSYHITYKEATGDDQVTLVEPASSTSVVLSNLKPETLYLVNVTAEYEDGFSIPLAGEETTAEVKGAPRNLKVTDETTDSFKITWTQAPGRVLRYRITYRPVAGGESKEVTTPANQRRRTLENLTPDTKYEVSVIPEYVSGPGSPLTGNAATEEVRGNPRDLRVSDPTTSTMKLSWTRAPGKVKQYLITYTPVAGGDTQEVTVKGDTASTVLRGLNEGTQYALSVTALYASGAGDALFGEGTTLEERGSPGDLITKDITDTSIGAYWTSAPGMVRGYRVSWQSLYDDIETGEKSLPADVIHTVIENLQPETKYRVSIFATYSSGEGEPLSGEAMTELSEDSKTLKVDEETENTMRVTWKPAPGKVVNYRVMYRPRGGGRQMVAKVSPTVTSTVLKRLQPQTTYDITVLPVYKTGEGKLRQGSGTTASRFKSPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVVGPYDNTVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHKDKKSLLQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDIHAYNVADFDSLSRIVDDLTNNLCNSVKGPGDLEAPSNLVLSERTHRSMRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLERSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDIGSTTMHVQWQPVGGATGYTVTYEPINATVPTKPKEMRLEPTVNDVQLSDLFPNTEYAVTVQAVLHDLTSEPVTAREVTLPLPSPRDLKLRDVTHSTMNVAWEPAPGKVRKYIVRYKTPEEEAKEVEVDRSRASTPLKDLFSQTLYTVSVSAVYEEGESPPVTAQETTHTVPAPTNLQITEVTPESFRGTWDHGASDVSLYRITWAPSGSADKMETILNGDENTLVFQNLNPNTLYEVSVTAIYPDESESDDLIGSERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVLLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSSLNVRWDHAEGSPRQYKLFYAPTAGGPEELVPIPGNTNYAILRNLQPDTQYTVTVVPVYSEGDGGRTSDTGRTLVRGLARNVQVYNPTPNSLDVRWDSAPGPVQQYRIVYSPQDGTRPSESIVVPGNTYTVHLEQLIPDTPYSVNIVALYSDAEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIPVYEDGDGTHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEVFVGEVTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQVGWDTFCVRWLAHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTDLSPETDYGVTVFVQTPNLEGPGVSVKERTTLKPTEAPTEPPTPPPPPTIPPAREVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFHTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSSYRLQKNAFVNQPTVELHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKALFYGSFHKVHIVVTSKSVKIYIDCYEIVEKDIKEAGNITTDGYEILGKLLKGERKSATFQIQNFDIVCSPVWTSRDRCCDIPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGVSGAVGPPGPRGDTGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGPSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMNRFNQMLNQIPNDYHSSRNQPGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPQGERGLPGEKGERGIGSPGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPGSG", "length": 3065, "header": "tr|F1N401-1|F1N401_BOVIN Isoform 1 of Collagen alpha-1(XII) chain OS=Bos taurus OX=9913 GN=COL12A1 PE=3 SV=3 CANONICAL=F1N401-1" }, "locus": { "chromosome": "9", "start_pos": 14776366, "end_pos": 14663445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026725.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026725.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026725.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026725.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2305, "start_aa": "Thr", "end_pos": 2305, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2305", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2972, "start_aa": "Thr", "end_pos": 2972, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2972", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:359712", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:359712", "resource": "KEGG Pathway" }, { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RPW4-1", "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "COL12A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRTALCSAVAALCAAALLSSIEAEVNPPSDLNFTIIDEHNVQMSWKRPPDAIVGYRITVVPTNDGPTKEFTLSPSTTQTVLSDLIPEIEYVVSIASYDEVEESLPVFGQLTIQTGGPGIPEEKKVEAQIQKCSISAMTDLVFLVDGSWSVGRNNFRYILDFMVALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYFRRSDLLDAIKRIPYKGGNTMTGEAIDYLVKNTFTESAGARKGFPKVAIVITDGKAQDEVEIPARELRNIGVEVFSLGIKAADAKELKLIASQPSLKHVFNVANFDGIVDIQNEIILQVCSGVDEQLGELVSGEEVVEPASNLVATQISSKSVRITWDPSTSQITGYRVQFIPMIAGGKQHVLSVGPQTTALNVKDLSPDTEYQINVYAMKGLTPSEPITIMEKTQQVKVQVECSRGVDVKADVVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPRKVQISLVQYSRDPHMEFSLNRYNRVEDIIQAINTFPYRGGSTNTGKAMTYVREKVFVTSKGSRPNVPRVMILITDGKSSDAFKEPAIKLRDADVEIFAVGVKDAVRTELEAIASPPAETHVYTVEDFDAFQRISFELTQSVCLRIEQELAAIRKKSYVPAKNMVFSDVTSDSFKVSWSAAGSEVLSYLIKYKVAIGGDEFIVSVPASSTSSVLTNLLPETTYAVSVIAEYEDGDGPPLDGEETTLEVKGAPRNLRITDETTDSFIVGWTPAPGNVLRYRLVYRPLTGGERRQVTVSANERSTTLRNLIPDTRYEVSVIAEYQSGPGNALNGYAKTDEVRGNPRNLRVSDATTSTMKLSWSAAPGKVQQYFITYTPVAGGETKELTVKGDTTSKVLKGLDEATRYALTVSALYASGAGEALSGEGETLEERGSPRNLITTDITDTTVGLSWTPAPGTVNNYRIVWKSLYDDTMGEKRVPGNTVDAVLDGLEPETKYRISVYAAYSSGEGDPVEGEAFTDVSQSARTVTVDNETENTMRVSWQPSPGKVLSYRVYYRPRSGGRQMFGKVNASATSIVLKRLKPRTTYDLSVVPIYDFGQGKSRKAEGTTASPFKPPRNLRTSDSTMSSFRVTWEPAPGRVKGYKVTFHPTEDDRNLGELIVGPYDSTVVLEELRAGTTYKVNVFGMFDGGESNPLVGQEMTTLSDTTTEPFLSRGLECRTRAEADIVLLVDGSWSIGRPNFKTVRNFISRIVEVFDIGPDKVQIGLAQYSGDPRTEWNLNAYRTKEALLEAVTNLPYKGGNTLTGMALDFILKNNFKQEAGLRPRARKIGVLITDGKSQDDVVTPSRRLRDEGVELYAIGIKNADENELKQIATDPDDIHAYNVADFSFLASIVEDVTTNLCNSVKGPGDLPPPSNLVISEVTPHSFRLRWSPPPESVDRYRVEYYPTTGGPPKQFYVSRMETTTVLKDLTPETEYIVNVFSVVEDESSEPLIGREITYPLSSVRNLNVYDIGSTSMRVRWEPVNGATGYLLTYEPVNATVPTTEKEMRVGPSVNEVQLVDLIPNTEYTLTAYVLYGDITSDPLTSQEVTLPLPGPRGVTIRDVTHSTMNVLWDPAPGKVRKYIIRYKIADEADVKEVEIDRLKTSTTLTDLSSQRLYNVKVVAVYDEGESLPVAAEAVTQPVPSPVNLRITEITKNSFRGTWDHGAPDVSLYRITWGPYGRSEKAESIVNGDVNSLLFENLNPDTLYEVSVTAIYPDESESDDLIGSERTLPLVPITTPAPKSGPRNLQVYNATSHSLTVKWDPASGRVQRYKIIYQPINGDGPEQSTMVGGRQNSVVIQKLQPDTPYAITVSSMYADGEGGRMTGRGRTKPLTTVKNMLVYDPTTSTLNVRWDHAEGNPRQYKVFYRPTAGGAEEMTTVPGNTNYVILRSLEPNTPYTVTVVPVFPEGDGGRTTDTGRTLERGTPRNIQVYNPTPNSMNVRWEPAPGPVQQYRVNYSPLSGPRPSESIVVPANTRDVMLERLTPDTAYSINVIALYADGEGNPSQAQGRTLPRSGPRNLRVFDETTNSLSVQWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGIRNNVILQPLQSDTPYKITVVAVYEDGDGGQLTGNGRTVGLLPPQNIYITDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEVFVGEVTSYTLHNLSPSTTYDVNVYAQYDSGMSIPLTDQGTTLYLNVTDLTTYKIGWDTFCIRWSPHRSATSYRLKLNPADGSRGQEITVRGSETSHCFTGLSPDTEYNATVFVQTPNLEGPPVSVREHTVLKPTEAPTPPPTPPPPPTIPPARDVCRGAKADIVFLTDASWSIGDDNFNKVVKFVFNTVGAFDLINPAGIQVSFVQYSDEAKSEFKLNTFDDKAQALGALQNVQYRGGNTRTGKALTFIKEKVLTWESGMRRGVPKVLVVVTDGRSQDEVRKAATVIQHSGFSVFVVGVADVDYNELAKIASKPSERHVFIVDDFDAFEKIQDNLVTFVCETATSTCPLIYLEGYTSPGFKMLESYNLTEKHFASVQGVSLESGSFPSYVAYRLHKNAFVSQPIREIHPEGLPQAYTIIMLFRLLPESPSEPFAIWQITDRDYKPQVGVVLDPGSKVLSFFNKDTRGEVQTVTFDNDEVKKIFYGSFHKVHIVVTSSNVKIYIDCSEILEKPIKEAGNITTDGYEILGKLLKGDRRSATLEIQNFDIVCSPVWTSRDRCCDLPSMRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGLTGSSGPPGPRGETGPPGPQGPPGPQGPNGLSIPGEPGRQGMKGDAGQPGLPGRSGTPGLPGPPGPVGPPGERGFTGKDGPTGPRGPPGPAGAPGVPGVAGPSGKPGKPGDRGTPGTPGMKGEKGDRGDIASQNMMRAVARQVCEQLINGQMSRFNQMLNQIPNDYYSNRNQPGPPGPPGPPGAAGTRGEPGPGGRPGFPGPPGVQGPPGERGMPGEKGERGTGSQGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNAGIRGPPGPPGYCDSSQCASIPYNGQGFPEPYVPESGPYQPEGEPFIVPMESERREDEYEDYGVEMHSPEYPEHMRWKRSLSRKAKRKP", "length": 3122 }, "evidence": [ { "id": "F1N401", "url": "https://omabrowser.org/oma/group/F1N401/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RQI0-1", "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "COL12A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTRLPPALAALGAALLLSSIEAEVDPPSDLNFKIIDENTVHMSWARPADPIVGYRITVDPTTDGPTKEFTLAASTTETLLSELIPEVEYVVTITSYDEVEESVPVIGQLTIQTGDSKKKPGEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQFYQRDELLAAIKKIPYKGGNTMTGDAIDFLIKNTFTESAGARVGFPKVAIIITDGKSQDEVEIPARELRNIGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVIEPPSNLIATEVSSKYIKLSWTPSPSPVTGYKVLLTPMTTGSRQHALSVGPQTTMLSVRDLSADTEYQISVSAMKGLTASEPISIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDLSFSEVTSYSFNTSWSPAGENVFSYHITYKEATEDGEITVVEPASSTSVVLSNLKPETLYLVNVTAEYEDGFSIPLAGQETTAEVKGAPRNLKVTDETTDSFKITWTQAPGRVLRYRIIYRPVTGGESKEVTTPANQRRRTLENLTPDTKYEVSVIPEYFSGPGTPLTGNAATEEVRGNPRDLRVTDPTTSTMKLSWSGAPGKVKQYLVTYTPVAGGDTQEVTVRGDTTNTILRGLKEGTNYALSVTALYASGAGEALFGEGTTLEERGSPQGLVTKDITDTSIGAYWTSAPGMVRGYRVSWKSLYDDIEAGEKSLPGDAIYTVIENLQPETKYRVSVFATYSSGEGEPVSGEATTELSEDAKTLKVDEETENTMRVTWKPAPGKVLNYRVVYRPRGGGRQMVAKVPPAVTSTVLKRLQPQTTYDITVLPIYKAGEGKLRQGSGTTASRFKSPRNLRTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDNGRLGELVVGPYDNTVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLCNSVKGPGDLEAPSNLVISERTHRSLRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLESSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDVGSTAMRVQWQPVGGATGYALSYEPINATQPATPKEMRVEPTVNDVQLSDLFPNTEYKVTVQASLYDLTSEPVTAREVTLPLPSPRDLKLRDVTHSTMNVLWEPAPGQVRKYVVRYKTPEEDFKEVEVDRSQTSTPLKDLFSQTLYTVSVSAVYDEGESPPVTAQDTTRTVPAPTNLWISEVTPESFRGTWDHGASDVSLYRITWAPSGSTDKMETILNGDENTLVFENLNPNTLYEVSVTAIYPDESESDDLIGSERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTVGGRQNSVLLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSTLNVRWDHAEGSPRQYKLFYAMAGGPEEMVPIPGNTNYAILRNLQPDTPYTITVVPVYSEGDGGRTSDTGRTLVRGVATNIQVYNPTPNSLDVRWDPAPGPVQQYRLVYSPQAGTRPSESIVVPGNTRMVTLERLVPDTPYSVNIVALYADGEGDPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQSDTPYKITVIAVYEDGDGGHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEVFVGEVTSYTLHNLNPSTTYDVNVYAQYDSGLSAPLADQGTTLYLNVTDLKTYQVGWDTFCVRWSAHRAATSYRLKLSPSDGTRGQEITVRGSETSHCFTGLSPDNDYGVTVFVQTPNLEGPGVSVKEHTTVKPTEAPTEPPTPPPPPTIPPAREVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGAFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIQYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALIIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSAYRLQKNAFVNQPTAELHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKTLFYGSFHKVHIVVTSKSVKIYIDCYEIIEKNIQEAGNITTDGYEILGKLLKGERKSATFQIQNFDIVCSPVWTSRDRCCDIPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGISGAVGPPGPRGDMGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGPSGLKGEKGDRGDVASHNMMRAVARQVCEQLISGQMSRFNQMLNQIPNDYHSSRNQPGPPGPPGPPGSVGARGEPGPGGRPGFPGTPGMQGPPGERGLPGEKGERGIGSPGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASVPYNGQGYPGSG", "length": 3065 }, "evidence": [ { "id": "F1N401", "url": "https://omabrowser.org/oma/group/F1N401/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P70560-1", "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "Col12a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "PGEPGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGTPGSPGVAGPSGKPGKPGDHGRPGQSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMSRFNQMLNQIPNDYHSNRNQPGPPGPPGPPGAAGARGEPGPGGAPGFPGRPGVQGPPGERGLPGEKGERGIGSQGPRGPPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPEPYVPEGGAYLPDREPFIVPVEPERTAEYEDDYGADEPEQQHPDHRRWRRALRPGPGQ", "length": 317 }, "evidence": [ { "id": "F1N401", "url": "https://omabrowser.org/oma/group/F1N401/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q60847-1", "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "Col12a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQTRLPRALAALGVALLLSSIEAEVDPPSDLNFKIIDENTVHMSWERPVDPIVGYRITVDPTTDGPTKEFTLAASTTETLLSDLIPETQYVVTITSYNEVEESVPVIGQLTIQTGGPTKPGEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIVALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYRREDLLAAVKKIPYKGGNTMTGDAIDYLVKNTFTESAGSRAGFPKVAIIITDGKSQDEVEIPARELRNIGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVIEPPSNLVVTELSSKYIRLSWDPSPSAVTGYKILLTPMAAGSRHHALSVGPQTTTLNVRDLTADTEYQISVFAMKGLTSSEPTSVMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLAKSFEISPNRVQISLVQYSRDPHTEFTLKEFNRVEDIIKAINTFPYRGGSTNTGKAMTYVREKIFVPNKGSRSNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDLRFTQVTANSFKAEWSPPGDNVFSYHVTYKDANGDDEVTVVEPASSTSVVLNNLRPETLYLVNVTAEYEDGFSVPITGEETTAEVKGVPRNLKVTDETTDSFKLTWSQAPGRVLRYRIRYRPVSGGESKEVSTPANQRRKTLENLTPDTKYEISVIAEYSSGPGSPLTGNAATEEVRGNPRDLRVSDATTSTLKLSWSRAPGKVKQYLVTYTPAAGGETQEVTVRGDTTTTMLRKLKEGTQYDLSVTALYASGAGEALSGKGSTLEERGSPQNLVTKDITDTSIGAYWTSAPGMVRGYRVSWKSLYDDIEAGETTLPGDAIHTMIENLQPETKYKISVFATYSSGEGEPVTGDATTELSQDSKILRVDEETEHTMRVTWKAAPGKVVNYRVVYRPQGGGRQMVAKVPPTVTSTVLKRLQPQTTYDITVLPMYKTGEGKLRQGSGTTASRFKSPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVLGPYDNTVVLEELRAGTTYRVNVFGMFDGGESLPLVGQEMTTLSDTTVTPFLSSGMDCLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSKIVDDLTINLCNSVKGPGDLEAPTNLVISERTHRSFRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLDTSTVLKDLKPETDYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDVGPTTMHVQWQPVGGATGYTVSYQPTRSPEGTKPKEMRVGPTVNDVQLTGLLPNTEYEVTVQAVLYDLTSEPAKAREVTLPLPRPQDVKLRDVTHSTMNVVWEPVLGKVRKYIVRYKTPDEEFKEVEVDRSRASTILKDLSSQTQYTVSVSAVYDEGTSPPATAYDTTRRVPAPTNLQFTEVTPESFRGTWDHGASDVSLYRITWAPVGNPDKMETILNGDENTLVFENLNPNTPYEVSITAIYPDESESEDLSGTERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTITVGGRQNSVLLQKLKPDTPYTITVYSQYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSSLSVRWDHAEGNPRQYKLFYAPTSGGPEELVPIPGNTNYAILRNLQPDTPYTITVVPVYTEGDGGRTSDTGRTLVRGLARNIQVYNPTPNSLDVRWDPAPGPVQQYRIVYSPVAGTRPSESIVVPGNTRTVHLERLIPDTPYSVNIVALYSDGEGNPSPSQGRTLPRSGPRNIRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIAIYEDGDGGHLTGNGRTVGLLPPQNIHIFDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEAFVGEVTSYTLHNLNPSTTYDVSVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQVGWDTFCVKWSPHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTGLSPEAEYGVTVFVQTPNLEGPGVPIKEQTTVKPTEAPTEPPTPSPPPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGAFDEVNPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAAFVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSAYRLQKNAFINQPTAELHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYRPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKTLFYGSFHKVHIVVTSKSVKIYIDCYEIIEKDIKEAGNITTDGYEILGKLLKGERKSATFQIQSFDIVCSPVWTSRDRCCDIPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERGINGAVGPPGPRGDTGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGQSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMSRFNQMLNQIPNDYHSSRNQPGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPPGERGLPGEKGERGTGSQGPRGPPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPEPYVPEGGAYLPEREPFIVPVEPERTAEYEDDYGADEPDQQHPDHMRWRRALRPGPAE", "length": 3120 }, "evidence": [ { "id": "F1N401", "url": "https://omabrowser.org/oma/group/F1N401/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99715-1", "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "COL12A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSRLPPALAALGAALLLSSIEAEVDPPSDLNFKIIDENTVHMSWAKPVDPIVGYRITVDPTTDGPTKEFTLSASTTETLLSELVPETEYVVTITSYDEVEESVPVIGQLTIQTGSSTKPVEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVGFPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIAMEVSSKYVKLNWNPSPSPVTGYKVILTPMTAGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGMTSSEPISIMEKTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQISLVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSNVPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDLSFSEVTSYGFKTNWSPAGENVFSYHITYKEAAGDDEVTVVEPASSTSVVLSSLKPETLYLVNVTAEYEDGFSIPLAGEETTEEVKGAPRNLKVTDETTDSFKITWTQAPGRVLRYRIIYRPVAGGESREVTTPPNQRRRTLENLIPDTKYEVSVIPEYFSGPGTPLTGNAATEEVRGNPRDLRVSDPTTSTMKLSWSGAPGKVKQYLVTYTPVAGGETQEVTVRGDTTNTVLQGLKEGTQYALSVTALYASGAGDALFGEGTTLEERGSPQDLVTKDITDTSIGAYWTSAPGMVRGYRVSWKSLYDDVDTGEKNLPEDAIHTMIENLQPETKYRISVFATYSSGEGEPLTGDATTELSQDSKTLKVDEETENTMRVTWKPAPGKVVNYRVVYRPHGRGKQMVAKVPPTVTSTVLKRLQPQTTYDITVLPIYKMGEGKLRQGSGTTASRFKSPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVVGPYDNTVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADIVLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGKSQDDVEAPSKKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLCNSVKGPGDLEAPSNLVISERTHRSFRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRMETSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDVGPTTMHVQWQPVGGATGYILSYKPVKDTEPTRPKEVRLGPTVNDMQLTDLVPNTEYAVTVQAVLHDLTSEPVTVREVTLPLPRPQDLKLRDVTHSTMNVFWEPVPGKVRKYIVRYKTPEEDVKEVEVDRSETSTSLKDLFSQTLYTVSVSAVHDEGESPPVTAQETTRPVPAPTNLKITEVTSEGFRGTWDHGASDVSLYRITWAPFGSSDKMETILNGDENTLVFENLNPNTIYEVSITAIYPDESESDDLIGSERTLPILTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVVLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSTLNVRWDHAEGNPRQYKLFYAPAAGGPEELVPIPGNTNYAILRNLQPDTSYTVTVVPVYTEGDGGRTSDTGRTLMRGLARNVQVYNPTPNSLDVRWDPAPGPVLQYRVVYSPVDGTRPSESIVVPGNTRMVHLERLIPDTLYSVNLVALYSDGEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIAVYEDGDGGHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPMEAFVGEMTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQIGWDTFCVKWSPHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTGLSPDTDYGVTVFVQTPNLEGPGVSVKEHTTVKPTEAPTEPPTPPPPPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGVADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFASVQGVSLESGSFPSYSAYRIQKNAFVNQPTADLHPNGLPPSYTIILLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTEEVKTLFYGSFHKVHIVVTSKSVKIYIDCYEIIEKDIKEAGNITTDGYEILGKLLKGERKSAAFQIQSFDIVCSPVWTSRDRCCDIPSRRDEGKCPAFPNSCTCTQDSVGPPGPPGPAGGPGAKGPRGERGISGAIGPPGPRGDIGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPGPSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMNRFNQMLNQIPNDYQSSRNQPGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPPGERGLPGEKGERGTGSSGPRGLPGPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYPGSG", "length": 3063 }, "evidence": [ { "id": "F1N401", "url": "https://omabrowser.org/oma/group/F1N401/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401" } ], "pmid": "" }, { "name": "tissue development", "id": "GO:0009888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009888", "evidence": [ { "database": "UniProtKB", "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401" } ], "pmid": "" }, { "name": "endodermal cell differentiation", "id": "GO:0035987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035987", "evidence": [ { "database": "UniProtKB", "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "interstitial matrix", "id": "GO:0005614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005614", "evidence": [ { "database": "UniProtKB", "id": "F1N401", "url": "https://www.uniprot.org/uniprotkb/F1N401" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1511, "end_pos": 1513, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1765, "end_pos": 1767, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2208, "end_pos": 2210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2530, "end_pos": 2532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2681, "end_pos": 2683, "annotation": "n_glycosylation_sequon" }, { "start_pos": 639, "end_pos": 641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 700, "end_pos": 702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 781, "end_pos": 783, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N401" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 117, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N401" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 140, "end_pos": 316, "start_aa": "Asp", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 2305, 2972 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1511, "end_pos": 1513 }, { "start_pos": 1765, "end_pos": 1767 }, { "start_pos": 2208, "end_pos": 2210 }, { "start_pos": 2530, "end_pos": 2532 }, { "start_pos": 2681, "end_pos": 2683 }, { "start_pos": 639, "end_pos": 641 }, { "start_pos": 700, "end_pos": 702 }, { "start_pos": 781, "end_pos": 783 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1432 }, { "field": "total_sites", "count": 1135 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1394 }, { "field": "total_sites", "count": 1120 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 38 }, { "field": "total_sites", "count": 33 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 148 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4I2-1", "uniprot_ac": "F2Z4I2", "uniprot_id": "F2Z4I2_BOVIN", "mass": { "chemical_mass": 46939.0, "monoisotopic_mass": 46939.0 }, "refseq": { "ac": "XP_005226428", "name": "AP-3 complex subunit mu-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226428" }, "gene_names": [ { "name": "AP3M1", "type": "recommended", "evidence": [ { "id": "F2Z4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ] }, { "name": "AP3M1", "type": "synonym", "evidence": [ { "id": "XP_005226428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226428" } ] } ], "protein_names": [ { "name": "AP-3 complex subunit mu-1", "type": "recommended", "evidence": [ { "id": "F2Z4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2/entry#names_and_taxonomy" } ] }, { "name": "AP-3 complex subunit mu-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005226428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226428" } ] } ], "function": [ { "annotation": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX4#function" }, { "database": "UniProtKB", "id": "PIRNR005992", "url": "https://www.uniprot.org/uniprotkb/PIRNR005992#function" }, { "database": "UniProtKB", "id": "A0AAA9U200", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U200#function" }, { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP3M1", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2", "locus": { "chromosome": "28", "start_pos": 29991385, "end_pos": 30013013, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021883", "url": "https://www.ensembl.org/id/ENSBTAG00000021883" } ] } } ], "crossref": [ { "id": "F2Z4I2", "url": "https://alphafold.ebi.ac.uk/entry/F2Z4I2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021883", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021883", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14837", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14837", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514761", "url": "https://www.ncbi.nlm.nih.gov/gene/514761", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "INVHFTI", "url": "https://omabrowser.org/oma/group/INVHFTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F2Z4I2", "url": "https://www.orthodb.org/?gene=F2Z4I2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10529", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10529", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00928", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00928", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005226428", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226428", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U200", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U200", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U200-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U200-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4I2-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT", "length": 418, "header": "tr|F2Z4I2-1|F2Z4I2_BOVIN Isoform 1 of AP-3 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP3M1 PE=3 SV=1 CANONICAL=F2Z4I2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX4/entry", "sequence": { "sequence": "MSEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT", "length": 404, "header": "tr|A0AAA9SVX4-1|F2Z4I2_BOVIN Computationally mapped isoform of AP-3 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP3M1 PE=3 SV=1 CANONICAL=F2Z4I2-1" }, "locus": { "chromosome": "28", "start_pos": 30012775, "end_pos": 29993349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122567.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122567.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088168.1" } ] } }, { "isoform_ac": "A0AAA9U200-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U200/entry", "sequence": { "sequence": "MSLGEYEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT", "length": 408, "header": "tr|A0AAA9U200-1|F2Z4I2_BOVIN Computationally mapped isoform of AP-3 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP3M1 PE=3 SV=1 CANONICAL=F2Z4I2-1" }, "locus": { "chromosome": "28", "start_pos": 30011775, "end_pos": 29993349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131475.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131475.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103362.1" } ] } }, { "isoform_ac": "F2Z4I2-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2/entry", "sequence": { "sequence": "MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT", "length": 418, "header": "tr|F2Z4I2-1|F2Z4I2_BOVIN Isoform 1 of AP-3 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP3M1 PE=3 SV=1 CANONICAL=F2Z4I2-1" }, "locus": { "chromosome": "28", "start_pos": 30004097, "end_pos": 29993349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029169.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029169.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029169.4", "url": "https://www.ensembl.org/id/ENSBTAP00000029169.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AM27-1", "protein_name": "AP-3 complex subunit mu-1", "gene_name": "AP3M1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT", "length": 418 }, "evidence": [ { "id": "F2Z4I2", "url": "https://omabrowser.org/oma/group/F2Z4I2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZNE7-1", "protein_name": "AP-3 complex subunit mu-1", "gene_name": "AP3M1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSQPTAADPVAFRAAQPGAEAWVSALCSHPTWSPVQNALKGIAEKMIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAIDVENVPPVISTPHHYLISIYRDKIFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSETAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVIEEIDAIIDKSGSTVFAEIQGVIDSCIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHLISFKENSSSGRFDVTIGPKQNMGKTVEGVVMTVHMPKAVLNMNLTATQGSYTFDPVTKVLAWDVGKITPQKLPNLKGIVNLQSGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYITKAGKFQVRT", "length": 464 }, "evidence": [ { "id": "F2Z4I2", "url": "https://omabrowser.org/oma/group/F2Z4I2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4I562-1", "protein_name": "AP-3 complex subunit mu", "gene_name": "AP3M", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLQCIFLISDSGEVMLEKQLTGHRVDRSICAWFWDQYISQGDSFKALPVIASPTHYLFQIVRDGITFLACSQVEMPPLMAIEFLCRVADVLSEYLGGLNEDLIKDNFIIVYELLDEMIDNGFPLTTEPSILKEMIAPPNLVSKMLSVVTGNASNVSDTLPSGAGSCVPWRPTDPKYSSNEVYVDLVEEMDAIVNRDGELVKCEIYGEVQMNSQLTGFPDLTLSFANPSILEDMRFHPCVRYRPWESHQVLSFVPPDGEFKLMSYRVKKLKNTPVYVKPQITSDSGTCRISVLVGIRSDPGKTIESITLSFQLPHCVSSADLSSNHGTVTILSNKTCTWTIGRIPKDKTPCLSGTLALEPGLERLHVFPTFKLGFKIMGIALSGLRIEKLDLQTIPPRLYKGFRAQTRAGEFDVRL", "length": 415 }, "evidence": [ { "id": "F2Z4I2", "url": "https://omabrowser.org/oma/group/F2Z4I2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O76928-1", "protein_name": "Carmine, isoform A", "gene_name": "cm", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIHSLFIVNSGGEVFLEKHWRSVVSRSVCEYFLDAQRAAPYDVPPVIATPHYYLITVQRDTVSLVAACKQEVPPLFVIEFLHRVVDTFQDYFGDCSESVIKDNYVVVYELLDEMLDNGFPLATESNILKELIKPPNILRTIANTVTGKSNVSTTLPSGQLSAVRWRRSGVRYTNNEAYFDVIEEVDAIIDKSGSTVFAEIQGHIDCCIKLSGMPDLTLSFMNPRLFDDVSFHPCVRYKRWEAERLLSFIPPDGNFRLMSYHISSQSVVAIPIYIRHNFSIKTGEQGRLDLTIGPRNTLGRTVDKVKLELTMPRCVLNCLLTPNQGKYTFDSVTKTLSWDVGRIDVSKLPNIRGSVSITPGTTNIDANPSVNVQFQISQLAVSGLKVNRLDMYGEKYKPFKGVKYLTKAGKFQVRM", "length": 415 }, "evidence": [ { "id": "F2Z4I2", "url": "https://omabrowser.org/oma/group/F2Z4I2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9GPF1-1", "protein_name": "AP-3 complex subunit mu", "gene_name": "apm3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLSSFFIIADQGDILIEKHWRGLMNRSICEYFWDQVLQSKQNGSSVPPIISTPKYYLINIQKQNVYLLGVCQSEVSPLLVVDFLQRIYDTFVEYFGSNITSATIKENFVHVYQLLDEMADNGFPFTTELNFLKEMIKPPGVLSNVISSVTGTSNITDILPNGSLGAIQWRKTGIKYTQNKIFFDIIEEIDCIIDSNGYIVSSEINGEILCHCNLSGMPDLTMTFNNPRMLDDVSFHPCVRYSRWENDRVLSFIPPDGNFKLLSYRVKGINQFPVYVKPQISYSEGSSSVGRVNVTVGAKGYNVQNKLSIEDVVATIPFSKTTSSTNLTANIGSFGMDEQSKILRWNIGKIPKEKTPFLNGTVSLIAGSMTPESTPSIMLQFKIPQYAISGLTIDSLACSERYKPFKGVKCTTKAGKFQVRS", "length": 421 }, "evidence": [ { "id": "F2Z4I2", "url": "https://omabrowser.org/oma/group/F2Z4I2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9JKC8-1", "protein_name": "AP-3 complex subunit mu-1", "gene_name": "Ap3m1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIYRDKLFFVSVIQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKENSSCGRFDITIGPKQNMGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKITPQKLPSLKGLVNLQSGAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYVTKAGKFQVRT", "length": 418 }, "evidence": [ { "id": "F2Z4I2", "url": "https://omabrowser.org/oma/group/F2Z4I2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "clathrin adaptor complex", "id": "GO:0030131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030131", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "postsynaptic recycling endosome", "id": "GO:0098837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098837", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "AP-1 adaptor complex", "id": "GO:0030121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030121", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "postsynaptic neurotransmitter receptor internalization", "id": "GO:0098884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098884", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "anterograde synaptic vesicle transport", "id": "GO:0048490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048490", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "Golgi to vacuole transport", "id": "GO:0006896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006896", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" }, { "name": "clathrin adaptor activity", "id": "GO:0035615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035615", "evidence": [ { "database": "UniProtKB", "id": "F2Z4I2", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F2Z4I2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 418, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F2Z4I2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F2Z4I2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F2Z4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4I2" }, { "id": "PS51072", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51072" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MHD", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 417, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 285, "end_pos": 287 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6H6-1", "uniprot_ac": "F1N6H6", "uniprot_id": "F1N6H6_BOVIN", "mass": { "chemical_mass": 109347.0, "monoisotopic_mass": 109347.0 }, "refseq": { "ac": "NP_001192751", "name": "ephrin type-A receptor 10 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192751" }, "gene_names": [ { "name": "EPHA10", "type": "recommended", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] }, { "name": "EPHA10", "type": "synonym", "evidence": [ { "id": "NP_001192751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192751" } ] } ], "protein_names": [ { "name": "Ephrin type-A receptor 10", "type": "recommended", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6/entry#names_and_taxonomy" } ] }, { "name": "2.7.10.1", "type": "synonym", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6/entry#names_and_taxonomy" } ] }, { "name": "ephrin type-A receptor 10 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192751", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192751" } ] } ], "function": [ { "annotation": "Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6#function" }, { "database": "UniProtKB", "id": "ARBA00054353", "url": "https://www.uniprot.org/uniprotkb/ARBA00054353#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPHA10", "url": "https://www.uniprot.org/uniprotkb/F1N6H6", "locus": { "chromosome": "3", "start_pos": 108191354, "end_pos": 108149712, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020510", "url": "https://www.ensembl.org/id/ENSBTAG00000020510" } ] } } ], "crossref": [ { "id": "F1N6H6", "url": "https://alphafold.ebi.ac.uk/entry/F1N6H6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540439", "url": "https://www.ncbi.nlm.nih.gov/gene/540439", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540439", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540439", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ATQLVCM", "url": "https://omabrowser.org/oma/group/ATQLVCM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6H6", "url": "https://www.orthodb.org/?gene=F1N6H6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46877:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46877:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01404", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01404", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14575", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14575", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25599", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25599", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2682334", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928663", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928663", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928665", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192751", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SW53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N6H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METGAGPHPLRLFICLMPLCLALLLGPGRPGTAEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWIGRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRTRPGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQCRATVRGLAAFPATAAESAFSTLVEVTGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDICEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLALRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFVPRQVGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGATYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANGTEYEIRYFEKGQSEQTYSTVKTGAPAVTVTNLKPATRYVFQIRAASPGPSWETQSFNPSIEVLTPGEATSRSKDQSPAVVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGRDAHDEEELYFHFKVPTRRTFVDPQSCGDPLQAVHLFAKELDAKSVTLEKSLGTGRFGELCCGCLQLPGRQELPVAVHTLREGCSDSQRLSFLAEALTLGQFDHSHVVRLEGVVTRGSTLMIVIEYMSHGALDGFLRRHEGQLVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSELVCKISGFGRGPRDRAEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGVVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSPLHRLMLDCWQKDPGERPRFSQIHGLLSKMMQDPEPPRCADTTCARPPTPLEDRAFSTFPSFGSVGAWLEALDLGRYKDSFAAAGYGSLEAVAAMTAQDLVSLGISSAEHREDLLSGISALRARVLQLQGRGVQV", "length": 1008, "header": "tr|F1N6H6-1|F1N6H6_BOVIN Isoform 1 of Ephrin type-A receptor 10 OS=Bos taurus OX=9913 GN=EPHA10 PE=4 SV=3 CANONICAL=F1N6H6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW53/entry", "sequence": { "sequence": "METGAGPHPLRLFICLMPLCLALLLGPGRPGTAEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWIGRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRTRPGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQCRATVRGLAAFPATAAESAFSTLVEVTGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDICEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLALRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFVPRQVGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGATYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANGTEYEIRYFEKGQSEQTYSTVKTGAPAVTVTNLKPATRYVFQIRAASPGPSWETQSFNPSIEVLTPGEATSRSKDQSPAVVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGRDAHDEEELYFHFKVPTRRTFVDPQSCGDPLQAVHLFAKELDAKSVTLEKSLGTGFEVSHR", "length": 660, "header": "tr|A0AAA9SW53-1|F1N6H6_BOVIN Computationally mapped isoform of Ephrin type-A receptor 10 OS=Bos taurus OX=9913 GN=EPHA10 PE=4 SV=1 CANONICAL=F1N6H6-1" }, "locus": { "chromosome": "3", "start_pos": 108187134, "end_pos": 108149712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128414.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128414.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088246.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088246.1" } ] } }, { "isoform_ac": "F1N6H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N6H6/entry", "sequence": { "sequence": "METGAGPHPLRLFICLMPLCLALLLGPGRPGTAEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWIGRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRTRPGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQCRATVRGLAAFPATAAESAFSTLVEVTGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDICEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLALRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFVPRQVGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGATYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANGTEYEIRYFEKGQSEQTYSTVKTGAPAVTVTNLKPATRYVFQIRAASPGPSWETQSFNPSIEVLTPGEATSRSKDQSPAVVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGRDAHDEEELYFHFKVPTRRTFVDPQSCGDPLQAVHLFAKELDAKSVTLEKSLGTGRFGELCCGCLQLPGRQELPVAVHTLREGCSDSQRLSFLAEALTLGQFDHSHVVRLEGVVTRGSTLMIVIEYMSHGALDGFLRRHEGQLVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSELVCKISGFGRGPRDRAEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGVVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSPLHRLMLDCWQKDPGERPRFSQIHGLLSKMMQDPEPPRCADTTCARPPTPLEDRAFSTFPSFGSVGAWLEALDLGRYKDSFAAAGYGSLEAVAAMTAQDLVSLGISSAEHREDLLSGISALRARVLQLQGRGVQV", "length": 1008, "header": "tr|F1N6H6-1|F1N6H6_BOVIN Isoform 1 of Ephrin type-A receptor 10 OS=Bos taurus OX=9913 GN=EPHA10 PE=4 SV=3 CANONICAL=F1N6H6-1" }, "locus": { "chromosome": "3", "start_pos": 108190350, "end_pos": 108149712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033263.7", "url": "https://www.ensembl.org/id/ENSBTAT00000033263.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033182.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033182.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:540439", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540439", "resource": "KEGG Pathway" }, { "id": "R-BTA-2682334", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682334", "resource": "Reactome", "description": "EPH-Ephrin signaling" }, { "id": "R-BTA-3928663", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928663", "resource": "Reactome", "description": "EPHA-mediated growth cone collapse" }, { "id": "R-BTA-3928665", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928665", "resource": "Reactome", "description": "EPH-ephrin mediated repulsion of cells" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LX55-1", "protein_name": "Ephrin type-A receptor 10", "gene_name": "Epha10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METGAGPHPLRLFVCLMPLCLALLLGPGRPGTAEEVTLLDSKASQAELGWTALPSTGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGATGTCKETFNAYYLETEADLGRGHPHLGGNRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQCRATVRGLAAFPATAAESAFSTLVEVAGTCVAHSEGEPSSPPRMHCGADGEWLVPVGRCSCSAGFQERGDICEACPPGFYKVSPRRPLCSPCPEHSLALENASTFCVCQDTYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLALRLRWLPPEDSGGRSDVTYSLLCLRCGRDGPAGACQPCGPRVAFVPRQAGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGATYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPVPAGASGTNRTEYEIRYYEKGQSEQTYSTVKTGAPAVTVTNLKPATRYVFQIRAASPGPSWEAQSFSPSIEVQTPGEVAPGSRDQSPAVVVTVVTISALLVLGSVMSVLAIWRRPCDGKGSGNAHDEEELYFHFKVPTRRTFLDPQSCGDPLQAVHLFAKELDAKSVTLEKSLGAGRFGDLCCGCLQLPGRQELPVAVHTLREGCSDSQKLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLGALDDFLRHHEAELVTAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLLSSGLICKISGFGRGPRDRAEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPGERPRFSQIHSILSKMGQEPEPSKCASTTCLRPPTPLADRAFSAFPSFGSVGAWLEALDLCRYKDNFSAAGYGSLEAVTEMTAQDLGSLGISSAEHREALLSGISALQTRVLQLQGQGVQV", "length": 1007 }, "evidence": [ { "id": "F1N6H6", "url": "https://omabrowser.org/oma/group/F1N6H6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5JZY3-1", "protein_name": "Ephrin type-A receptor 10", "gene_name": "EPHA10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METCAGPHPLRLFLCRMQLCLALLLGPWRPGTAEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRPRLGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRRGFHLAFQDVGACVALVSVRVYYKQCRATVRGLATFPATAAESAFSTLVEVAGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDFCEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFLPRQAGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQIRAASPGPSWEAQSFNPSIEVQTLGEAASGSRDQSPAIVVTVVTISALLVLGSVMSVLAIWRRPCSYGKGGGDAHDEEELYFHFKVPTRRTFLDPQSCGDLLQAVHLFAKELDAKSVTLERSLGGGRFGELCCGCLQLPGRQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQIHSILSKMVQDPEPPKCALTTCPRPPTPLADRAFSTFPSFGSVGAWLEALDLCRYKDSFAAAGYGSLEAVAEMTAQDLVSLGISLAEHREALLSGISALQARVLQLQGQGVQV", "length": 1008 }, "evidence": [ { "id": "F1N6H6", "url": "https://omabrowser.org/oma/group/F1N6H6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" }, { "name": "ephrin receptor activity", "id": "GO:0005003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005003", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" }, { "name": "transmembrane-ephrin receptor activity", "id": "GO:0005005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005005", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1N6H6", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MWN2-1", "A0AAF6DMB3-1", "E1BI01-1", "A0AAA9TQL1-1", "F1MQH2-1", "F1N781-1", "F6QXU6-1", "A0A3Q1MKW9-1", "A0A3Q1M0U5-1", "F6S1J8-1", "A5D791-1", "F1N664-1", "E1BMP9-1", "F1MS00-1", "P43481-1", "A0A3Q1LR28-1", "A0A3Q1LVP1-1", "Q06807-1", "A0AAA9TD48-1", "Q5E9X2-1", "Q05688-1", "Q17R13-1", "E1BG90-1", "Q0VBZ0-1", "F1N758-1", "A0A3Q1LTC6-1", "A0A3Q1LNU2-1", "F1N1Q0-1", "A0A3Q1MHB0-1", "A0AAA9SN20-1", "A0AAA9TMY2-1", "A0A3Q1LI98-1", "E1BJ31-1", "A0A3Q1LRR9-1", "F1MX49-1", "A0A3Q1MHG9-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "E1BNE0-1", "A0A3Q1LT44-1", "A0A3Q1MJG0-1", "F1MII5-1", "F1N0D3-1", "F1N261-1", "F1N759-1", "F1N780-1", "F1MC14-1", "F1N3R6-1", "A0ABI0P1V8-1", "A0A3Q1LUE0-1", "F1MFH7-1", "F1MNW2-1", "A0AAA9SPC9-1", "F1N381-1", "F1MS29-1", "G1K218-1", "Q4TVR5-1", "A0AAA9SXH6-1", "E1BJS9-1", "A0AAA9SBR4-1", "F1MKR1-1", "F1MN51-1", "E1BCZ6-1", "E1BEL4-1", "F1MCX4-1", "F1N6J0-1", "Q3SZJ2-1", "Q769I5-1", "Z4YHD9-1", "Q06805-1", "Q3SX21-1", "A0A3Q1MAM7-1", "E1BPB5-1", "A0A3Q1MF99-1", "A0AAA9SA57-1", "A0AAA9TAT1-1", "A0AAA9THG2-1", "F1MC23-1", "A0AAA9SVL9-1", "F1MRU0-1", "A0AAA9T042-1", "E1BKP7-1", "E1BNA8-1", "F1ML02-1", "E1BPI3-1", "A0AAA9SW95-1", "G3X680-1", "A0AAA9TRY4-1", "A0A3Q1MEZ6-1", "E1B9H4-1", "E1B6X6-1", "E1B9Q2-1", "E1BPP1-1", "F1N6H6-1", "A0ABI0NRQ5-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-BTA-3928578", "name": "EPH receptors autophosphorylate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1MII5-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928578", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928578" } ] }, { "id": "R-BTA-3928591", "name": "EPH:EFN tetramers oligomerise", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1MII5-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928591" } ] }, { "id": "R-BTA-3928597", "name": "EPH:EFN dimers tetramerise", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1MII5-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928597", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928597" } ] }, { "id": "R-BTA-3928604", "name": "SFKs phosphorylate VAV2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "F1MII5-1", "F1N261-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928604" } ] }, { "id": "R-BTA-3928607", "name": "p-EPHs bind VAV2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "F1ML02-1", "A0AAA9THG2-1", "E1BJ31-1", "F1N6H6-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "F1MII5-1", "F1N261-1", "F1N3R6-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928607", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928607" } ] }, { "id": "R-BTA-3928646", "name": "EPHAs bind EFNAs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BJS9-1", "F1MFH7-1", "E1BJ31-1", "F1N6H6-1", "E1BER5-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928646", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928646" } ] }, { "id": "R-BTA-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61585-1", "E1BJS9-1", "F1MFH7-1", "E1BJ31-1", "F1N6H6-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "F1N261-1", "F1N780-1", "F1N781-1" ], "evidence": [ { "id": "R-BTA-3928651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928651" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LI98", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRR9", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] } ] }, { "uniprot_ac": "A0A3Q1LT44", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LUE0", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] } ] }, { "uniprot_ac": "A0A3Q1LVP1", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LVP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LVP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP1" } ] } ] }, { "uniprot_ac": "A0A3Q1M0U5", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1M0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U5" } ] } ] }, { "uniprot_ac": "A0A3Q1MAM7", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAM7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAM7" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MF99", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MF99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF99" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MF99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF99" } ] } ] }, { "uniprot_ac": "A0A3Q1MHB0", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] } ] }, { "uniprot_ac": "A0A3Q1MHG9", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] } ] }, { "uniprot_ac": "A0A3Q1MJG0", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] } ] }, { "uniprot_ac": "A0A3Q1MKW9", "gene_name": "ALK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] } ] }, { "uniprot_ac": "A0AAA9SA57", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] } ] }, { "uniprot_ac": "A0AAA9SBR4", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] } ] }, { "uniprot_ac": "A0AAA9SN20", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] } ] }, { "uniprot_ac": "A0AAA9SPC9", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] } ] }, { "uniprot_ac": "A0AAA9SVL9", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] } ] }, { "uniprot_ac": "A0AAA9SW95", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] } ] }, { "uniprot_ac": "A0AAA9SXH6", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9TAT1", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9THG2", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] } ] }, { "uniprot_ac": "A0AAA9TMY2", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] } ] }, { "uniprot_ac": "A0AAA9TQL1", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] } ] }, { "uniprot_ac": "A0AAA9TRY4", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] } ] }, { "uniprot_ac": "A0AAF6DMB3", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0P1V8", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] } ] }, { "uniprot_ac": "A0JNB0", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "E1B6X6", "gene_name": "BAZ1B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] } ] }, { "uniprot_ac": "E1B9H4", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BCZ6", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] } ] }, { "uniprot_ac": "E1BEL4", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] } ] }, { "uniprot_ac": "E1BER5", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BIM8", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] } ] }, { "uniprot_ac": "E1BJ31", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] } ] }, { "uniprot_ac": "E1BJS9", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] } ] }, { "uniprot_ac": "E1BKP7", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] } ] }, { "uniprot_ac": "E1BMP9", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] } ] }, { "uniprot_ac": "E1BNA8", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] } ] }, { "uniprot_ac": "E1BNE0", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "F1MC14", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] } ] }, { "uniprot_ac": "F1MC23", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] } ] }, { "uniprot_ac": "F1MCX4", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] } ] }, { "uniprot_ac": "F1MFH7", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] } ] }, { "uniprot_ac": "F1MII5", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] } ] }, { "uniprot_ac": "F1MKR1", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] } ] }, { "uniprot_ac": "F1ML02", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] } ] }, { "uniprot_ac": "F1MN51", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] } ] }, { "uniprot_ac": "F1MNW2", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] } ] }, { "uniprot_ac": "F1MQH2", "gene_name": "EPHA6", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] } ] }, { "uniprot_ac": "F1MRU0", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] } ] }, { "uniprot_ac": "F1MS00", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] } ] }, { "uniprot_ac": "F1MS29", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] } ] }, { "uniprot_ac": "F1MWN2", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] } ] }, { "uniprot_ac": "F1MX49", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] } ] }, { "uniprot_ac": "F1N0D3", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] } ] }, { "uniprot_ac": "F1N1Q0", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] } ] }, { "uniprot_ac": "F1N261", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] } ] }, { "uniprot_ac": "F1N381", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N381" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N381" } ] } ] }, { "uniprot_ac": "F1N3R6", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R6" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6H6", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] } ] }, { "uniprot_ac": "F1N6J0", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] } ] }, { "uniprot_ac": "F1N758", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] } ] }, { "uniprot_ac": "F1N759", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] } ] }, { "uniprot_ac": "F1N780", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N780" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N780" } ] } ] }, { "uniprot_ac": "F1N781", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] } ] }, { "uniprot_ac": "F6QXU6", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QXU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QXU6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6QXU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QXU6" } ] } ] }, { "uniprot_ac": "F6S1J8", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6S1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6S1J8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6S1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6S1J8" } ] } ] }, { "uniprot_ac": "G1K218", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "G1K218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K218" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G1K218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K218" } ] } ] }, { "uniprot_ac": "G3X680", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3X680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3X680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X680" } ] } ] }, { "uniprot_ac": "P43481", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "Q05688", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q05688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05688" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05688" } ] } ] }, { "uniprot_ac": "Q06805", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06805" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06805" } ] } ] }, { "uniprot_ac": "Q06807", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] } ] }, { "uniprot_ac": "Q0VBZ0", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q769I5", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q769I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q769I5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q769I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q769I5" } ] } ] }, { "uniprot_ac": "Z4YHD9", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6H6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1008, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6H6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6H6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" }, { "id": "PS51550", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51550" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Eph LBD", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 216, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 340, "end_pos": 452, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 645, "end_pos": 900, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 933, "end_pos": 997, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.10.1", "ec_name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.10.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1" }, { "id": "2.7.10.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.10.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 311, "end_pos": 313 }, { "start_pos": 486, "end_pos": 488 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1L4-1", "uniprot_ac": "F1N1L4", "uniprot_id": "F1N1L4_BOVIN", "mass": { "chemical_mass": 103346.0, "monoisotopic_mass": 103346.0 }, "refseq": { "ac": "NP_001180160", "name": "dipeptidyl peptidase 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180160" }, "gene_names": [ { "name": "DPP8", "type": "recommended", "evidence": [ { "id": "F1N1L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ] }, { "name": "DPP8", "type": "synonym", "evidence": [ { "id": "NP_001180160", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180160" } ] } ], "protein_names": [ { "name": "dipeptidyl-peptidase IV", "type": "recommended", "evidence": [ { "id": "F1N1L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L4/entry#names_and_taxonomy" } ] }, { "name": "3.4.14.5", "type": "synonym", "evidence": [ { "id": "F1N1L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L4/entry#names_and_taxonomy" } ] }, { "name": "dipeptidyl peptidase 8", "type": "synonym", "evidence": [ { "id": "NP_001180160", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180160" } ] } ], "function": [ { "annotation": "We showed the expression of DPP8 and DPP9 in the testis, epididymis, and sperm.", "evidence": [ { "database": "RefSeq", "id": "NP_001180160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180160" }, { "database": "PubMed", "id": "19188489", "url": "https://glygen.org/publication/PubMed/19188489" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPP8", "url": "https://www.uniprot.org/uniprotkb/F1N1L4", "locus": { "chromosome": "10", "start_pos": 12360195, "end_pos": 12427453, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014807", "url": "https://www.ensembl.org/id/ENSBTAG00000014807" } ] } } ], "crossref": [ { "id": "F1N1L4", "url": "https://alphafold.ebi.ac.uk/entry/F1N1L4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014807", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014807", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536604", "url": "https://www.ncbi.nlm.nih.gov/gene/536604", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536604", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536604", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PVTQWEL", "url": "https://omabrowser.org/oma/group/PVTQWEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJK9", "url": "https://www.orthodb.org/?gene=A0A3Q1LJK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1L4", "url": "https://www.orthodb.org/?gene=F1N1L4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11731", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11731", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11731:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11731:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00930", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00930", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180160", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJK9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJK9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1L4-1", "url": "https://www.uniprot.org/uniprotkb/F1N1L4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWKRSEQMKIQSGKCNMAAAMETEQLGVEIFETAECEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPEAETTPSGSRILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEILIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWAILLDRSQTRLQIVLISPELFIPVEDDAMERQRFIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRKLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISRHCDFFISKYSNQKSPHCVSLYKLSSPDDDPTCKTKEFWATLLDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 898, "header": "tr|F1N1L4-1|F1N1L4_BOVIN Isoform 1 of dipeptidyl-peptidase IV OS=Bos taurus OX=9913 GN=DPP8 PE=3 SV=2 CANONICAL=F1N1L4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJK9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJK9/entry", "sequence": { "sequence": "MWKRSEQMKIQSGKCNMAAAMETEQLGVEIFETAECEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPEAETTPSGSRILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEILIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWAILLDRSQTRLQIVLISPELFIPVEDDAMERQRFIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRKLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISRHCDFFISKYSNQKSPHCVSLYKLSSPDDDPTCKTKEFWATLLDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQCMYGLPWRLSGKESACQCRRHGFDP", "length": 883, "header": "tr|A0A3Q1LJK9-1|A0A3Q1LJK9_BOVIN Computationally mapped isoform of dipeptidyl-peptidase IV OS=Bos taurus OX=9913 GN=DPP8 PE=3 SV=2 CANONICAL=F1N1L4-1" }, "locus": { "chromosome": "10", "start_pos": 12422528, "end_pos": 12360705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076642.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076642.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059629.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059629.2" } ] } }, { "isoform_ac": "A0AAA9SY07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY07/entry", "sequence": { "sequence": "MWKRSEQMKIQSGKCNMAAAMETEQLGVEIFETAECEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPEAETTPSGSRILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEILIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWAILLDRSQTRLQIVLISPELFIPVEDDAMERQRFIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRKLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISRHCDFFISKYSNQKSPHCVSLYKLSSPDDDPTCKTKEFWATLLDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 847, "header": "tr|A0AAA9SY07-1|F1N1L4_BOVIN Computationally mapped isoform of dipeptidyl-peptidase IV OS=Bos taurus OX=9913 GN=DPP8 PE=3 SV=1 CANONICAL=F1N1L4-1" }, "locus": { "chromosome": "10", "start_pos": 12422528, "end_pos": 12374285, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089127.1" } ] } }, { "isoform_ac": "A0AAA9TQQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQQ7/entry", "sequence": { "sequence": "MAAAMETEQLGVEIFETAECEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPEAETTPSGSRILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEILIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWAILLDRSQTRLQIVLISPELFIPVEDDAMERQRFIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRKLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISRHCDFFISKYSNQKSPHCVSLYKLSSPDDDPTCKTKEFWATLLDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 782, "header": "tr|A0AAA9TQQ7-1|F1N1L4_BOVIN Computationally mapped isoform of dipeptidyl-peptidase IV OS=Bos taurus OX=9913 GN=DPP8 PE=3 SV=1 CANONICAL=F1N1L4-1" }, "locus": { "chromosome": "10", "start_pos": 12420291, "end_pos": 12374285, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100919.1" } ] } }, { "isoform_ac": "F1N1L4-1", "url": "https://www.uniprot.org/uniprotkb/F1N1L4/entry", "sequence": { "sequence": "MWKRSEQMKIQSGKCNMAAAMETEQLGVEIFETAECEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPEAETTPSGSRILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEILIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWAILLDRSQTRLQIVLISPELFIPVEDDAMERQRFIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRKLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISRHCDFFISKYSNQKSPHCVSLYKLSSPDDDPTCKTKEFWATLLDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 898, "header": "tr|F1N1L4-1|F1N1L4_BOVIN Isoform 1 of dipeptidyl-peptidase IV OS=Bos taurus OX=9913 GN=DPP8 PE=3 SV=2 CANONICAL=F1N1L4-1" }, "locus": { "chromosome": "10", "start_pos": 12422528, "end_pos": 12374285, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019706.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019706.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019706.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019706.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.", "journal": "The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society", "date": "2009", "authors": "Dubois V, Van Ginneken C, De Cock H, Lambeir AM, Van der Veken P, Augustyns K, Chen X, Scharpe S, De Meester I", "evidence": [ { "database": "RefSeq", "id": "NP_001180160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180160" } ], "reference": [ { "type": "PubMed", "id": "19188489", "url": "https://glygen.org/publication/PubMed/19188489" } ] } ], "pathway": [ { "id": "bta:536604", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536604", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P801-1", "protein_name": "dipeptidyl-peptidase IV", "gene_name": "DPP8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAMETEQPGLEVFETAGCEEQVQREEQPKPEPFYVERHSWSQLRKLLTDTRKYHGYMMAKAPHDFTFVKKNDPEGPHSDRIYYLAMSGENRENTLFYSEIPKTVNKAAVLLLSWKPLLDLFPAILDYGMYSREEELLRERKRIGTVGIASYDYHRESGTFLFQAGSGIYHVKDGGPHGFTQQPLRPILVETSCPNIRMDPKLCPADPNWIAFIHSNDIWISNIETREERRLTFVHNELANVEEDPKSAGVATFVLQEEFDRYTGYWWSPKAEPTLNGGKVLRILYEENDESEVEIIHVTSPMLETRRTDSFRYPKTGTANPKVTFKISEVVINEEGRIADVVDKELVQPFEILFEGVEYIARAGWTPEGKYVWSILLDRSQTRLQIVLIPPALFIPVEDDAMERQKLIDAVPDSVTPLIIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKIVSVLKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIYVDEAKKLVYFQGTKDSPLEHHLYVVNYKNPGEVKRLTERGYSHACCVSQDCDMFISKYSNQKNPHCVSLYRLTGHEDDAAQRTKEFWATILDSAGPLPDYIPPEVFSFESSTGFTLYGMMYKPHNLQPGKKYPTVIFIYGGPQVQLVNNRFKGLKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLHYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPEHNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLYYLQENLGSRIAALKAM", "length": 882 }, "evidence": [ { "id": "F1N1L4", "url": "https://omabrowser.org/oma/group/F1N1L4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2N3F3-1", "protein_name": "dipeptidyl-peptidase IV", "gene_name": "Dpp8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKIQSGKCNMAAAMETEQLGVEIFETAECEEGTIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRTDPDSPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNLVTREERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEILVDAEGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTHLQIVLISPELFIPVEDDAMDRQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKIISILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIWIDEVRKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDRGYSHSCCLSQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPVHKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 892 }, "evidence": [ { "id": "F1N1L4", "url": "https://omabrowser.org/oma/group/F1N1L4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6V1X1-1", "protein_name": "Dipeptidyl peptidase 8", "gene_name": "DPP8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 898 }, "evidence": [ { "id": "F1N1L4", "url": "https://omabrowser.org/oma/group/F1N1L4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80YA7-1", "protein_name": "Dipeptidyl peptidase 8", "gene_name": "Dpp8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKIPSGRCNMAAAMETEQLGVEIFETAECEEGNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRTDPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNLVTREERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAAGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKHAWSILLDRSQTHLQIVLISPELFIPVEDDAMDRQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEITITSGEWEVLGRHGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDRGYSHSCCLSRHCDFFISKYSNQKNPHCVSLYKLSSPEDDPVHKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI", "length": 892 }, "evidence": [ { "id": "F1N1L4", "url": "https://omabrowser.org/oma/group/F1N1L4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "dipeptidyl-peptidase activity", "id": "GO:0008239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008239", "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "pmid": "" }, { "name": "aminopeptidase activity", "id": "GO:0004177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004177", "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "pmid": "" }, { "name": "negative regulation of programmed cell death", "id": "GO:0043069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043069", "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1L4", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1L4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 898, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1L4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1L4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" }, { "id": "PF19520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dipeptidyl peptidase 8 /9 ,N-terminal", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 162, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" }, { "id": "PF00930", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00930" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dipeptidylpeptidase IV N-terminal", "eco_id": "ECO_0000259", "start_pos": 175, "end_pos": 594, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L4" }, { "id": "PF00326", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00326" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S9 prolyl oligopeptidase catalytic", "eco_id": "ECO_0000259", "start_pos": 687, "end_pos": 890, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.14.5", "ec_name": "Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.", "evidence": [ { "id": "3.4.14.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.14.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N648-1", "uniprot_ac": "F1N648", "uniprot_id": "F1N648_BOVIN", "mass": { "chemical_mass": 36411.0, "monoisotopic_mass": 36411.0 }, "refseq": {}, "gene_names": [ { "name": "KCTD13", "type": "recommended", "evidence": [ { "id": "F1N648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ] } ], "protein_names": [ { "name": "Potassium channel tetramerization domain containing 13", "type": "synonym", "evidence": [ { "id": "F1N648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N648/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in the control of excitability of cortical neurons.", "evidence": [ { "database": "UniProtKB", "id": "A0ABI0P242", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P242#function" }, { "database": "UniProtKB", "id": "ARBA00056682", "url": "https://www.uniprot.org/uniprotkb/ARBA00056682#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD13", "url": "https://www.uniprot.org/uniprotkb/F1N648", "locus": { "chromosome": "25", "start_pos": 26356561, "end_pos": 26343322, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015982", "url": "https://www.ensembl.org/id/ENSBTAG00000015982" } ] } } ], "crossref": [ { "id": "F1N648", "url": "https://alphafold.ebi.ac.uk/entry/F1N648", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015982", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015982", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FDPLCHI", "url": "https://omabrowser.org/oma/group/FDPLCHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N648", "url": "https://www.orthodb.org/?gene=F1N648", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11145:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11145:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T0F7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0F7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P242", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P242", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P242-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P242-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N648-1", "url": "https://www.uniprot.org/uniprotkb/F1N648-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAEASGPAAAEAPSLEVAKPSDLEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329, "header": "tr|F1N648-1|F1N648_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 13 OS=Bos taurus OX=9913 GN=KCTD13 PE=3 SV=1 CANONICAL=F1N648-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0F7/entry", "sequence": { "sequence": "MSAEASGPAAAEAPSLEVAKPSDLEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGAVVTNIHGPPATPHCQAQWLGAD", "length": 104, "header": "tr|A0AAA9T0F7-1|F1N648_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 13 OS=Bos taurus OX=9913 GN=KCTD13 PE=3 SV=1 CANONICAL=F1N648-1" }, "locus": { "chromosome": "25", "start_pos": 26345239, "end_pos": 26343484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113894.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113894.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089129.1" } ] } }, { "isoform_ac": "A0ABI0P242-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P242/entry", "sequence": { "sequence": "MSAEASGPAAAEAPSLEVAKPSDLEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 299, "header": "tr|A0ABI0P242-1|A0ABI0P242_BOVIN Computationally mapped isoform of BTB/POZ domain-containing protein KCTD7 OS=Bos taurus OX=9913 GN=KCTD13 PE=3 SV=1 CANONICAL=F1N648-1" }, "locus": { "chromosome": "25", "start_pos": 26356029, "end_pos": 26343484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143984.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143984.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106837.1" } ] } }, { "isoform_ac": "F1N648-1", "url": "https://www.uniprot.org/uniprotkb/F1N648/entry", "sequence": { "sequence": "MSAEASGPAAAEAPSLEVAKPSDLEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329, "header": "tr|F1N648-1|F1N648_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 13 OS=Bos taurus OX=9913 GN=KCTD13 PE=3 SV=1 CANONICAL=F1N648-1" }, "locus": { "chromosome": "25", "start_pos": 26356029, "end_pos": 26343484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021258.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021258.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021258.2", "url": "https://www.ensembl.org/id/ENSBTAP00000021258.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9696264", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "resource": "Reactome", "description": "RND3 GTPase cycle" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BQA2-1", "protein_name": "Potassium channel tetramerization domain containing 13", "gene_name": "KCTD13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAEASGPAAAEAQSLEVPKPAGLEPGSAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEENREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329 }, "evidence": [ { "id": "F1N648", "url": "https://omabrowser.org/oma/group/F1N648/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BGV7-1", "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "gene_name": "Kctd13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAEASGPAPAAAECLESPSPSSVEPGSPSYSLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESARELGELLGEARYYLVQGLIEDCQLALQQKREKLSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENSRGPDLALLEATGGAAGGGGAGRGDDEENREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329 }, "evidence": [ { "id": "F1N648", "url": "https://omabrowser.org/oma/group/F1N648/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WZ19-1", "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "gene_name": "KCTD13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKRETLSPLCLIPMVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGAGGAGRGEDEENREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329 }, "evidence": [ { "id": "F1N648", "url": "https://omabrowser.org/oma/group/F1N648/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "negative regulation of Rho protein signal transduction", "id": "GO:0035024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035024", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "stress fiber assembly", "id": "GO:0043149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043149", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "positive regulation of synaptic transmission", "id": "GO:0050806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050806", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "F1N648", "url": "https://www.uniprot.org/uniprotkb/F1N648" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N648-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 329, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N648-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N648" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N648" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 141, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4I7-1", "uniprot_ac": "F1N4I7", "uniprot_id": "F1N4I7_BOVIN", "mass": { "chemical_mass": 62767.0, "monoisotopic_mass": 62767.0 }, "refseq": {}, "gene_names": [ { "name": "DCP1A", "type": "recommended", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] } ], "protein_names": [ { "name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase", "type": "recommended", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.62", "type": "synonym", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCP1A", "url": "https://www.uniprot.org/uniprotkb/F1N4I7", "locus": { "chromosome": "22", "start_pos": 47690569, "end_pos": 47646509, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010863", "url": "https://www.ensembl.org/id/ENSBTAG00000010863" } ] } } ], "crossref": [ { "id": "F1N4I7", "url": "https://alphafold.ebi.ac.uk/entry/F1N4I7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010863", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010863", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09804", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09804", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR010334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SASRFKM", "url": "https://omabrowser.org/oma/group/SASRFKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4I7", "url": "https://www.orthodb.org/?gene=F1N4I7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16290:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16290:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06058", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16741", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16741", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-430039", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450385", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450385", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450513", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450513", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "67484", "url": "https://www.rhea-db.org/rhea/67484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T2G2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2G2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2G2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4I7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4I7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESLSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQISNLGSTETLEETPSGLQDKSAPSGHKHLTVEELFGTSLSKEQPAVVGLDSEEVEKLPGDASQKEPNSFLPFSFEPGGAPQSENLGVHPAAHPSVQPEVTTPVLITPASITQSSEKQAPSYAIPLHSVLSPSLPAEASTGQAPPSLPRKTTMMQTVKTAPRQRSPLLSQPVPELSHASLTASQSPFRAPLSVTNTTSPSLPSVDLLQKLRLTPQHDQIQPQSLGKGAAAPSFSPAAGQLATPESFIEPSPKATAARAPASLSNMVLAPLQSMQQNQDPEVFAQPKVLSSAIPVASSPLVPATTSAAPSVLLSPSVFQQTVTRSSDLERKASSPSPLTVGTTENQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNRDNHNL", "length": 579, "header": "tr|F1N4I7-1|F1N4I7_BOVIN Isoform 1 of 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase OS=Bos taurus OX=9913 GN=DCP1A PE=3 SV=2 CANONICAL=F1N4I7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2G2/entry", "sequence": { "sequence": "MESLSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERSAPSGHKHLTVEELFGTSLSKEQPAVVGLDSEEVEKLPGDASQKEPNSFLPFSFEPGGAPQSENLGVHPAAHPSVQPEVTTPVLITPASITQSSEKQAPSYAIPLHSVLSPSLPAEASTGQAPPSLPRKTTMMQTVKTAPRQRSPLLSQPVPELSHASLTASQSPFRAPLSVTNTTSPSLPSVDLLQKLRLTPQHDQIQPQSLGKGAAAPSFSPAAGQLATPESFIEPSPKATAARAPASLSNMVLAPLQSMQQNQDPEVFAQPKVLSSAIPVASSPLVPATTSAAPSVLLSPSVFQQTVTRSSDLERKASSPSPLTVGTTENQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNRDNHNL", "length": 541, "header": "tr|A0AAA9T2G2-1|F1N4I7_BOVIN Computationally mapped isoform of 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase OS=Bos taurus OX=9913 GN=DCP1A PE=3 SV=1 CANONICAL=F1N4I7-1" }, "locus": { "chromosome": "22", "start_pos": 47686694, "end_pos": 47646560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135829.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135829.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090824.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090824.1" } ] } }, { "isoform_ac": "F1N4I7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4I7/entry", "sequence": { "sequence": "MESLSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQISNLGSTETLEETPSGLQDKSAPSGHKHLTVEELFGTSLSKEQPAVVGLDSEEVEKLPGDASQKEPNSFLPFSFEPGGAPQSENLGVHPAAHPSVQPEVTTPVLITPASITQSSEKQAPSYAIPLHSVLSPSLPAEASTGQAPPSLPRKTTMMQTVKTAPRQRSPLLSQPVPELSHASLTASQSPFRAPLSVTNTTSPSLPSVDLLQKLRLTPQHDQIQPQSLGKGAAAPSFSPAAGQLATPESFIEPSPKATAARAPASLSNMVLAPLQSMQQNQDPEVFAQPKVLSSAIPVASSPLVPATTSAAPSVLLSPSVFQQTVTRSSDLERKASSPSPLTVGTTENQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNRDNHNL", "length": 579, "header": "tr|F1N4I7-1|F1N4I7_BOVIN Isoform 1 of 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase OS=Bos taurus OX=9913 GN=DCP1A PE=3 SV=2 CANONICAL=F1N4I7-1" }, "locus": { "chromosome": "22", "start_pos": 47686694, "end_pos": 47646560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014415.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014415.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014415.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014415.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-430039", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "resource": "Reactome", "description": "mRNA decay by 5' to 3' exoribonuclease" }, { "id": "R-BTA-450385", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450385", "resource": "Reactome", "description": "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" }, { "id": "R-BTA-450513", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450513", "resource": "Reactome", "description": "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AE80-1", "protein_name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase", "gene_name": "Dcp1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALSCSPVRPRPRGSAWRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEEARRAQQAARDKQSPSQANGCSDQRPIDILEMLSRAKDEYERNQMGGSNISSPGLQPSSQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAPMGLESEDTDKLLGDAPQKEPSSFLPFPFEQSGGAPQAENLGVHSVTHHTVQPEVSAPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTMMQAVRTTPRQKSPLLNQPVPELSHSSLIASQSPFRAPVSLANTAGTAIPSSDLLQKLRLTPQHDQIQAQPLGKGAMAPNFSSAAGQLATPESFIEPSSKTAAARAAVAASLSNMVLAPTLQSMQQNQDPEVFAQPKVLPSAIPIAGPPLVTATTTAVSSVLLSPSVFQQTVPRSADLERKASCPSPLTIGAENQRKPSIILSRSQLQDTLIHLIKNDSGFLSTLHEVYLQVLTKSKDNHSL", "length": 601 }, "evidence": [ { "id": "F1N4I7", "url": "https://omabrowser.org/oma/group/F1N4I7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LHS8-1", "protein_name": "mRNA-decapping enzyme 1A", "gene_name": "DCP1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESLSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVLEEETRRSQQAARDKQSPNQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQISNLGSTETLEETPSGLQDKSALSGHKHLTVEELFGTSLPKEQPTVVGLESEEVEKLPGDASQKEPSSFLPFSFEPSGGGPQSENMGIRPAAHHSVQPEVTTPVLITPASITQSSEKQAPSYAIPLHPVLSPTLPAEASTAQAPPSLPRSTTMMQAVKTTPRQRSPLSSQPVPELSQASLAASQSPFRAPLNVTNTASTSLPSVDLLQKLRLTQQHDQIQTQSLGKGAVAPSFSPAAGQLATPESFIEPPPKTAAARASASLSNMVLAPLQSMQQNQDPEVFAQPKVLSSAIPVAGPALVTATTSAVSSVLLSPSVFQQTVTRSSDLERKASSPSPLTVGTSENQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL", "length": 580 }, "evidence": [ { "id": "F1N4I7", "url": "https://omabrowser.org/oma/group/F1N4I7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q91YD3-1", "protein_name": "mRNA-decapping enzyme 1A", "gene_name": "Dcp1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALSCSTVRPRRRGSALRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDQRPIDILEMLSRAKDEYERNQMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPTAMGLESEDTDKLLGDASQKEPSSFLPFPFEQSGGAPQSENLGIHSAAHHTVQPEVSTPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTMIQAVKTTPRQKSPLLNQPVPELSHSSLVASQSPFRAPVSLANPAGTALPSVDLLQKLRLTPQHDQIQAQPLGKGTMAPSFSSAAGQLATPESFIEPSSKTAAARAAVSASLSNMVLAPTLQSMQQNQDPEVFSQPKVLPSAIPIAGSPLVPATTTAVSSVLLSPSVFQQTVPRAADLERKASSPSPLTVGTAESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHAVYLQVLTKNKDNHNL", "length": 602 }, "evidence": [ { "id": "F1N4I7", "url": "https://omabrowser.org/oma/group/F1N4I7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPI6-1", "protein_name": "mRNA-decapping enzyme 1A", "gene_name": "DCP1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIPVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL", "length": 582 }, "evidence": [ { "id": "F1N4I7", "url": "https://omabrowser.org/oma/group/F1N4I7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "id": "GO:0000290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "protein localization to cytoplasmic stress granule", "id": "GO:1903608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903608", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "deadenylation-independent decapping of nuclear-transcribed mRNA", "id": "GO:0031087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031087", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "id": "GO:0140933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140933", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N4I7", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67484", "name": "", "equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N4I7-1", "F1MLY3-1", "A0AAF6ZJ25-1", "A1A4Q9-1", "A2VE79-1", "Q3SZL6-1", "A4FUG7-1", "A0AAA9SRY7-1", "A0AAA9TYZ1-1" ], "evidence": [ { "id": "67484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67484" } ] }, { "id": "R-BTA-429860", "name": "DCP1-DCP2 complex decaps mRNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-430004" ], "enzyme_list": [ "E1BDM8-1", "F1N4I7-1", "F1MLY3-1" ], "evidence": [ { "id": "R-BTA-429860", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429860" } ] }, { "id": "R-BTA-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N4I7-1", "E1BMZ8-1" ], "evidence": [ { "id": "R-BTA-450431", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450431" } ] }, { "id": "R-BTA-450488", "name": "BRF1 Complex recruits RNA degradation activities", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N4I7-1", "E1BMZ8-1" ], "evidence": [ { "id": "R-BTA-450488", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450488" } ] }, { "id": "R-BTA-927813", "name": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P67774-1", "Q3T169-1", "Q2NL22-1", "E1BFK4-1", "F1N4I7-1", "A0AAA9TMV7-1" ], "evidence": [ { "id": "R-BTA-927813", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-927813" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-430004", "participant_name": "7-MeGDP [cytosol]", "crossref": [ { "id": "20794", "database": "ChEBI", "url": "" }, { "id": "HMDB0001107", "database": "HMDB Metabolite", "url": "" }, { "id": "ZINC000018130229", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SRY7", "gene_name": "DCP2", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TYZ1", "gene_name": "NUDT17", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A0AAA9TYZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ1" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A0AAA9TYZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ1" } ] } ] }, { "uniprot_ac": "A0AAF6ZJ25", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] }, { "ec_number": "3.6.1.64", "activity": "", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] } ] }, { "uniprot_ac": "A1A4Q9", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] } ] }, { "uniprot_ac": "A2VE79", "gene_name": "NUDT3", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.52", "activity": "6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.10", "activity": "[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.61", "activity": "P(1),P(6)-bis(5'-adenosyl) hexaphosphate + H2O = 2 ATP + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.52", "activity": "", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] } ] }, { "uniprot_ac": "A4FUG7", "gene_name": "NUDT17", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A4FUG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUG7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A4FUG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUG7" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BFK4", "gene_name": "SMG6", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BFK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFK4" } ] } ] }, { "uniprot_ac": "E1BMZ8", "gene_name": "XRN1", "activity": [ { "ec_number": "3.1.13.-", "activity": "", "evidence": [ { "id": "E1BMZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMZ8" } ] } ] }, { "uniprot_ac": "F1MLY3", "gene_name": "DCP1B", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "F1MLY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY3" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "F1MLY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY3" } ] } ] }, { "uniprot_ac": "F1N4I7", "gene_name": "DCP1A", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q3SZL6", "gene_name": "DCP1B", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] } ] }, { "uniprot_ac": "Q3T169", "gene_name": "RPS3", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "Q3T169", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T169" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "Q3T169", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T169" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4I7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4I7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4I7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" }, { "id": "PF16741", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16741" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "mRNA-decapping enzyme C-terminal", "eco_id": "ECO_0000259", "start_pos": 538, "end_pos": 577, "start_aa": "Ile", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.62", "ec_name": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "3.6.1.62", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62" }, { "id": "3.6.1.62", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.62" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 554, "end_pos": 556 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4B2-1", "uniprot_ac": "F1N4B2", "uniprot_id": "F1N4B2_BOVIN", "mass": { "chemical_mass": 56243.0, "monoisotopic_mass": 56243.0 }, "refseq": {}, "gene_names": [ { "name": "SLC2A6", "type": "recommended", "evidence": [ { "id": "F1N4B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ] } ], "protein_names": [ { "name": "Solute carrier family 2, facilitated glucose transporter member 6", "type": "recommended", "evidence": [ { "id": "F1N4B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B2/entry#names_and_taxonomy" } ] }, { "name": "Glucose transporter type 6", "type": "synonym", "evidence": [ { "id": "F1N4B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable sugar transporter that acts as a regulator of glycolysis in macrophages. Does not transport glucose.", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2#function" }, { "database": "UniProtKB", "id": "ARBA00053035", "url": "https://www.uniprot.org/uniprotkb/ARBA00053035#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC2A6", "url": "https://www.uniprot.org/uniprotkb/F1N4B2", "locus": { "chromosome": "11", "start_pos": 104361570, "end_pos": 104368819, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001824", "url": "https://www.ensembl.org/id/ENSBTAG00000001824" } ] } } ], "crossref": [ { "id": "F1N4B2", "url": "https://alphafold.ebi.ac.uk/entry/F1N4B2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001824", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001824", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510658", "url": "https://www.ncbi.nlm.nih.gov/gene/510658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4B2", "url": "https://www.orthodb.org/?gene=F1N4B2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48021", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48021", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48021:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48021:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T6N3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6N3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4B2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4B2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQEPLLGAEGRDYDTFPEKPPPSPGERTRVGVLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALEHSSDPNLNLTKTQASWFGSVFTLGAAAGGLSAMVLNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRMLTGFAGGLTAACIPPGPACVLSRDWVGCVLQVYVSEIAPPSVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLVMVLLLSCMPNSPRFLLSKGRDAEALQALAWLRGPDADTRWEFEQIQDTVRRQSSHLSWAEARDPHMYRPIVIALLMRFLQQLTGITPILVYLQSIFDSTAVLLPPKVDAAIVGAVRLLSVLIAALTMDLAGRKALLFVSAAGMFAANLTLGLYVHFGPKSLAPNSSMGLGREALAGTEQPLATPTSYLTLVPLLATMLFIMGYAMGWGPITWLLMSEILPLRARGVASGLCVLVSWLTAFALTKSFLLVTNAFGLQAPFFFFAAVCLVNLAFTGCCVPETKGRSLEQIESFFRTGRRSFLH", "length": 524, "header": "tr|F1N4B2-1|F1N4B2_BOVIN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 6 OS=Bos taurus OX=9913 GN=SLC2A6 PE=3 SV=2 CANONICAL=F1N4B2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6N3/entry", "sequence": { "sequence": "MQEPLLGAEGRDYDTFPEKPPPSPGERTRVGVLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALEHSSDPNLNLTKTQASWFGSVFTLGAAAGGLSAMVLNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRMLTGFAGGLTAACIPVYVSEIAPPSVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLVMVLLLSCMPNSPRFLLSKGRDAEALQALAWLRGPDADTRWEFEQIQDTVRRQSSHLSWAEARDPHMYRPIVIALLMRFLQQLTGITPILVYLQSIFDSTAVLLPPKVDAAIVGAVRLLSVLIAALTMDLAGRKALLFVSGYAMGWGPITWLLMSEILPLRARGVASGLCVLVSWLTAFALTKSFLLVTNAFGLQAPFFFFAAVCLVNLAFTGCCVPETKGRSLEQIESFFRTGRRSFLH", "length": 445, "header": "tr|A0AAA9T6N3-1|F1N4B2_BOVIN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 6 OS=Bos taurus OX=9913 GN=SLC2A6 PE=3 SV=1 CANONICAL=F1N4B2-1" }, "locus": { "chromosome": "11", "start_pos": 104368798, "end_pos": 104362140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125459.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125459.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094420.1" } ] } }, { "isoform_ac": "F1N4B2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4B2/entry", "sequence": { "sequence": "MQEPLLGAEGRDYDTFPEKPPPSPGERTRVGVLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALEHSSDPNLNLTKTQASWFGSVFTLGAAAGGLSAMVLNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRMLTGFAGGLTAACIPPGPACVLSRDWVGCVLQVYVSEIAPPSVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLVMVLLLSCMPNSPRFLLSKGRDAEALQALAWLRGPDADTRWEFEQIQDTVRRQSSHLSWAEARDPHMYRPIVIALLMRFLQQLTGITPILVYLQSIFDSTAVLLPPKVDAAIVGAVRLLSVLIAALTMDLAGRKALLFVSAAGMFAANLTLGLYVHFGPKSLAPNSSMGLGREALAGTEQPLATPTSYLTLVPLLATMLFIMGYAMGWGPITWLLMSEILPLRARGVASGLCVLVSWLTAFALTKSFLLVTNAFGLQAPFFFFAAVCLVNLAFTGCCVPETKGRSLEQIESFFRTGRRSFLH", "length": 524, "header": "tr|F1N4B2-1|F1N4B2_BOVIN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 6 OS=Bos taurus OX=9913 GN=SLC2A6 PE=3 SV=2 CANONICAL=F1N4B2-1" }, "locus": { "chromosome": "11", "start_pos": 104368798, "end_pos": 104362140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002385.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002385.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002385.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002385.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-189200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "resource": "Reactome", "description": "Cellular hexose transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of glycolytic process", "id": "GO:0006110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006110", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1N4B2", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4B2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 524, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4B2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4B2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4B2" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 504, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 370, "end_pos": 372 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6Q087-1", "uniprot_ac": "F6Q087", "uniprot_id": "F6Q087_BOVIN", "mass": { "chemical_mass": 68742.0, "monoisotopic_mass": 68742.0 }, "refseq": { "ac": "NP_001091540", "name": "eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091540" }, "gene_names": [ { "name": "GSPT1", "type": "recommended", "evidence": [ { "id": "F6Q087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ] }, { "name": "GSPT1", "type": "synonym", "evidence": [ { "id": "NP_001091540", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091540" } ] } ], "protein_names": [ { "name": "G1 to S phase transition 1", "type": "synonym", "evidence": [ { "id": "F6Q087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q087/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "type": "synonym", "evidence": [ { "id": "NP_001091540", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091540" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GSPT1", "url": "https://www.uniprot.org/uniprotkb/F6Q087", "locus": { "chromosome": "25", "start_pos": 10560415, "end_pos": 10590303, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003577", "url": "https://www.ensembl.org/id/ENSBTAG00000003577" } ] } } ], "crossref": [ { "id": "F6Q087", "url": "https://alphafold.ebi.ac.uk/entry/F6Q087", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003577", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003577", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01883", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01883", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03704", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03704", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04089", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04089", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532337", "url": "https://www.ncbi.nlm.nih.gov/gene/532337", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532337", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532337", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DLCWFDD", "url": "https://omabrowser.org/oma/group/DLCWFDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6Q087", "url": "https://www.orthodb.org/?gene=F6Q087", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72764", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72764", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001091540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091540", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T9Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNI7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNI7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q087-1", "url": "https://www.uniprot.org/uniprotkb/F6Q087-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPGSGGGGGGGGGGSSSSSDSAPDCWDQADMEAPGPGPCGGAGGPLAAAVAEAQREHLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQLPASPAGAAANNHGAGNGAGGPSAPVESSQEEQSLLCEGSNSAVSMELSEPIENGETEMSPEESWEHKEEISEAEPDGGSLGDGRPAEESAQEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 636, "header": "tr|F6Q087-1|F6Q087_BOVIN Isoform 1 of G1 to S phase transition 1 OS=Bos taurus OX=9913 GN=GSPT1 PE=3 SV=2 CANONICAL=F6Q087-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y2/entry", "sequence": { "sequence": "MDPGSGGGGGGGGGGSSSSSDSAPDCWDQADMEAPGPGPCGGAGGPLAAAVAEAQREHLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQLPASPAGAAANNHGAGNGAGGPSVENGETEMSPEESWEHKEEISEAEPDGGSLGDGRPAEESAQEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 608, "header": "tr|A0AAA9T9Y2-1|F6Q087_BOVIN Computationally mapped isoform of G1 to S phase transition 1 OS=Bos taurus OX=9913 GN=GSPT1 PE=3 SV=1 CANONICAL=F6Q087-1" }, "locus": { "chromosome": "25", "start_pos": 10590073, "end_pos": 10561312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093445.1" } ] } }, { "isoform_ac": "A0ABI0NNI7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNI7/entry", "sequence": { "sequence": "MNTENERRPELSLKCRANSDWGQGGGRWKERERAPVESSQEEQSLLCEGSNSAVSMELSEPIVENGETEMSPEESWEHKEEISEAEPDGGSLGDGRPAEESAQEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 554, "header": "tr|A0ABI0NNI7-1|A0ABI0NNI7_BOVIN Computationally mapped isoform of G1 to S phase transition 1 OS=Bos taurus OX=9913 GN=GSPT1 PE=3 SV=1 CANONICAL=F6Q087-1" }, "locus": { "chromosome": "25", "start_pos": 10590948, "end_pos": 10561312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138115.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138115.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107266.1" } ] } }, { "isoform_ac": "F6Q087-1", "url": "https://www.uniprot.org/uniprotkb/F6Q087/entry", "sequence": { "sequence": "MDPGSGGGGGGGGGGSSSSSDSAPDCWDQADMEAPGPGPCGGAGGPLAAAVAEAQREHLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQLPASPAGAAANNHGAGNGAGGPSAPVESSQEEQSLLCEGSNSAVSMELSEPIENGETEMSPEESWEHKEEISEAEPDGGSLGDGRPAEESAQEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 636, "header": "tr|F6Q087-1|F6Q087_BOVIN Isoform 1 of G1 to S phase transition 1 OS=Bos taurus OX=9913 GN=GSPT1 PE=3 SV=2 CANONICAL=F6Q087-1" }, "locus": { "chromosome": "25", "start_pos": 10590073, "end_pos": 10561312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004656.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004656.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004656.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004656.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532337", "resource": "KEGG Pathway" }, { "id": "R-BTA-72764", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72764", "resource": "Reactome", "description": "Eukaryotic Translation Termination" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PYQ3-1", "protein_name": "G1 to S phase transition 2", "gene_name": "GSPT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEANGSGSSSDSAPDCWDQADIETGSGASSGSAPPAVEAEAQQELLGAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGAPAPGLPPPSPPPGLPPPHGLPVETSPEEQTASYEGSNAAVNMEISESVVENGETEMSPEESWEHKEETSEAELGSGPVVDAGPSEESTQEMMEEEEEMPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSEFCPWYIGLPFIPYLDNLPNFNRSADGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKTGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 618 }, "evidence": [ { "id": "F6Q087", "url": "https://omabrowser.org/oma/group/F6Q087/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LNK5-1", "protein_name": "G1 to S phase transition 1", "gene_name": "GSPT1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPGSGGGGGGGGGGSSSGSSSSDSAPDCWDQADMEAPGPGPCGGAGGPLAAAAAEAQREHLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQPSAPPAGAAANNHGAGSGAGGPSAPVEPSQEEQSLLCEGSNSAVSMELSEPVVENGETEMSPEESWEHKEEISEAETGVGPLGDGRPTEESAQEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 640 }, "evidence": [ { "id": "F6Q087", "url": "https://omabrowser.org/oma/group/F6Q087/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P15170-1", "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "gene_name": "GSPT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 499 }, "evidence": [ { "id": "F6Q087", "url": "https://omabrowser.org/oma/group/F6Q087/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AYD5-1", "protein_name": "G1 to S phase transition 1", "gene_name": "Gspt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPSSGGGGGGGGGGGGSSSSSSDSAPDCWDQTDMEAPGPGPCGGGSMAAVAEAQRENLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQPPLSPAGAAGGDHGAGSSAGGPSEPVESSQEQSLCEGSNSTVSMELSEPVVENGETEMSPEESWEHKEEISEAEPAGGGSSGDGRPPEESTQEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLIPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDLNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 636 }, "evidence": [ { "id": "F6Q087", "url": "https://omabrowser.org/oma/group/F6Q087/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R050-1", "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "gene_name": "Gspt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPSSGGGGGGGGGGSSSSSDSAPDCWDQTDMEAPGPGPCGGGGSGSGSMAAVAEAQRENLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQPPLSPAGAAGGDHGAGSGAGGPSEPVESSQDQSCEGSNSTVSMELSEPVVENGETEMSPEESWEHKEEISEAEPGGGSSGDGRPPEESTQEMMEEEEEIPKPKSAVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDLNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 636 }, "evidence": [ { "id": "F6Q087", "url": "https://omabrowser.org/oma/group/F6Q087/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" }, { "name": "translation release factor activity", "id": "GO:0003747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003747", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" }, { "name": "translation release factor complex", "id": "GO:0018444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018444", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" }, { "name": "regulation of translational termination", "id": "GO:0006449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006449", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "F6Q087", "url": "https://www.uniprot.org/uniprotkb/F6Q087" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6Q087-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 636, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6Q087-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6Q087" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6Q087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q087" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 435, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 365, "end_pos": 367 }, { "start_pos": 432, "end_pos": 434 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QDZ3-1", "uniprot_ac": "F6QDZ3", "uniprot_id": "F6QDZ3_BOVIN", "mass": { "chemical_mass": 33561.0, "monoisotopic_mass": 33561.0 }, "refseq": {}, "gene_names": [ { "name": "USE1", "type": "recommended", "evidence": [ { "id": "F6QDZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ] } ], "protein_names": [ { "name": "Vesicle transport protein USE1", "type": "recommended", "evidence": [ { "id": "F6QDZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3/entry#names_and_taxonomy" } ] }, { "name": "USE1-like protein", "type": "synonym", "evidence": [ { "id": "F6QDZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "USE1", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3", "locus": { "chromosome": "7", "start_pos": 5878515, "end_pos": 5881729, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011134", "url": "https://www.ensembl.org/id/ENSBTAG00000011134" } ] } } ], "crossref": [ { "id": "F6QDZ3", "url": "https://alphafold.ebi.ac.uk/entry/F6QDZ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011134", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011134", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15860", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15860", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR019150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KYYTNAQ", "url": "https://omabrowser.org/oma/group/KYYTNAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6QDZ3", "url": "https://www.orthodb.org/?gene=F6QDZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13050:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13050:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TI86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QDZ3-1", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQQTNRALPTGKRPRRALPPSLKMAPAEGAEYHWVVMAASRLELNLVRLLCRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKAQASKPASEVLNEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSSEEPELDVRKRTGASGPTPRDEKQSAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTESERLEQHTQKSVNWLLWAMLIVVCFIFISMILFIRIMPKLK", "length": 297, "header": "tr|F6QDZ3-1|F6QDZ3_BOVIN Isoform 1 of Vesicle transport protein USE1 OS=Bos taurus OX=9913 GN=USE1 PE=3 SV=1 CANONICAL=F6QDZ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TI86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI86/entry", "sequence": { "sequence": "MAASRLELNLVRLLCRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKAQASKPASEVLNEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSSEEPELDVRKRTPCHTHS", "length": 148, "header": "tr|A0AAA9TI86-1|F6QDZ3_BOVIN Computationally mapped isoform of Vesicle transport protein USE1 OS=Bos taurus OX=9913 GN=USE1 PE=3 SV=1 CANONICAL=F6QDZ3-1" }, "locus": { "chromosome": "7", "start_pos": 5881419, "end_pos": 5878692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093643.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093643.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098002.1" } ] } }, { "isoform_ac": "F6QDZ3-1", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3/entry", "sequence": { "sequence": "MGQQTNRALPTGKRPRRALPPSLKMAPAEGAEYHWVVMAASRLELNLVRLLCRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKAQASKPASEVLNEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSSEEPELDVRKRTGASGPTPRDEKQSAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTESERLEQHTQKSVNWLLWAMLIVVCFIFISMILFIRIMPKLK", "length": 297, "header": "tr|F6QDZ3-1|F6QDZ3_BOVIN Isoform 1 of Vesicle transport protein USE1 OS=Bos taurus OX=9913 GN=USE1 PE=3 SV=1 CANONICAL=F6QDZ3-1" }, "locus": { "chromosome": "7", "start_pos": 5881530, "end_pos": 5878531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014785.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014785.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014785.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014785.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 185, "start_aa": "Thr", "end_pos": 185, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr185", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6811434", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LA05-1", "protein_name": "Vesicle transport protein USE1", "gene_name": "Use1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQAEGAGHRPLATSRLELNLVRLLCRCESMAAEKREPNEWRLEKYVGALEDMLQALKVQASKPASEVISEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGMDSSGEREMDMRQRIANGSRPVDEKHSVSELDLVLQRHQGLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKMESERLEQHTRKSVDWLLWAMLIVVCFVFISMILFIRVMPRLK", "length": 270 }, "evidence": [ { "id": "F6QDZ3", "url": "https://omabrowser.org/oma/group/F6QDZ3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6A1D9-1", "protein_name": "Vesicle transport protein USE1", "gene_name": "Use1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPALPPLSKMAQAEGACHRPLATSRLELNLVRLLCRCESMAAEKREPDEWRLEKYVGALEDMLQALKVQASKPASEVISEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTAKERVPATKTVHLQSRARYTSEMRSELLGTESSGELEADMRKRVVKGPRPADEKQSASELDLVLQRHQGLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKLESERLEQHAQKSVNWLLWAMLIVVCFVFISMILFIRIMPRLK", "length": 279 }, "evidence": [ { "id": "F6QDZ3", "url": "https://omabrowser.org/oma/group/F6QDZ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AAU3-1", "protein_name": "Vesicle transport protein USE1", "gene_name": "USE1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAATRLELNLMRLLSRCEALAAERRDPEEWRLEKYVAALEDMLRELKKQSSKPPPELLNEYTRKVDFLKGLLEAEKLSSSTEKALANQFLAPGRTPTTVKERTPATKTVHLQTKARCTGKMRSELLGTDPLAISDSEEPNIRKRKGLAPDEKQSAVELDAVLQHHQDMQEKLAEEMLSLARSLKNNTLAAQNVIKQDNQTLSHSLRMADQNFEKLKDESDRLEQHAKKSVNWLLWIMLIVVCFIFISMILFIRIFPKLK", "length": 259 }, "evidence": [ { "id": "F6QDZ3", "url": "https://omabrowser.org/oma/group/F6QDZ3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9CQ56-1", "protein_name": "Vesicle transport protein USE1", "gene_name": "Use1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQAEGAYHRPLATSRLELNLVRLLCRCESMAAEKREPDEWRLEKYVGALEDMLQALKVQASKPASEVISEYSRKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTAKERVPATKTVHLQSRARYTSEMRSELLGMEPSGECEVDMRKRAAKGSRPADERQSASELDLVLQRHQGLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKLESERLEQHAQKSVNWLLWAMLIVVCFVFISMILFIRIMPRLK", "length": 270 }, "evidence": [ { "id": "F6QDZ3", "url": "https://omabrowser.org/oma/group/F6QDZ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZ43-1", "protein_name": "Vesicle transport protein USE1", "gene_name": "USE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASRLELNLVRLLSRCEAMAAEKRDPDEWRLEKYVGALEDMLQALKVHASKPASEVINEYSWKVDFLKGMLQAEKLTSSSEKALANQFLAPGRVPTTARERVPATKTVHLQSRARYTSEMRSELLGTDSAEPEMDVRKRTGVAGSQPVSEKQLAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSVIKKDNQTLSHSLKMADQNLEKLKTESERLEQHTQKSVNWLLWAMLIIVCFIFISMILFIRIMPKLK", "length": 259 }, "evidence": [ { "id": "F6QDZ3", "url": "https://omabrowser.org/oma/group/F6QDZ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VSU7-1", "protein_name": "Vesicle transport protein USE1", "gene_name": "Use1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATKLNVNIRTLLANCEELAKSEQNFWRLQKFIKSLDTMLAELEAMGDPQSVKRIPGYLERLQALKISTGYADVPGSTTKTPSQSSAVSETGENALKEIRQLQNSKYHNELRKELLQDSDALRRRRGADESSSSSGSANVQETSGENMNQAAKYYTNAQEKITEHMLSLTRNLKEQTETANRIIRRDTEVVSRSAGMADRNINSLGKEAEKLEQHSKKAYKCWLWLMIAFVIATFIGMVLFMKIMKKKKS", "length": 250 }, "evidence": [ { "id": "F6QDZ3", "url": "https://omabrowser.org/oma/group/F6QDZ3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SNAP receptor activity", "id": "GO:0005484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484", "evidence": [ { "database": "UniProtKB", "id": "F6QDZ3", "url": "https://www.uniprot.org/uniprotkb/F6QDZ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QDZ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QDZ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QDZ3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 185 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 236, "end_pos": 238 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F2Z4H8-1", "uniprot_ac": "F2Z4H8", "uniprot_id": "F2Z4H8_BOVIN", "mass": { "chemical_mass": 45214.0, "monoisotopic_mass": 45214.0 }, "refseq": {}, "gene_names": [ { "name": "TIAL1", "type": "recommended", "evidence": [ { "id": "F2Z4H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ] } ], "protein_names": [ { "name": "Nucleolysin TIAR", "type": "recommended", "evidence": [ { "id": "F2Z4H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8/entry#names_and_taxonomy" } ] }, { "name": "TIA-1-related protein", "type": "synonym", "evidence": [ { "id": "F2Z4H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TKW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKW8#function" }, { "database": "UniProtKB", "id": "ARBA00057653", "url": "https://www.uniprot.org/uniprotkb/ARBA00057653#function" }, { "database": "UniProtKB", "id": "A0ABI0NZF6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZF6#function" }, { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIAL1", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8", "locus": { "chromosome": "26", "start_pos": 39698133, "end_pos": 39717667, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004080", "url": "https://www.ensembl.org/id/ENSBTAG00000004080" } ] } } ], "crossref": [ { "id": "F2Z4H8", "url": "https://alphafold.ebi.ac.uk/entry/F2Z4H8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004080", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004080", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12616", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12616", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12617", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12617", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12620", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12620", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614540", "url": "https://www.ncbi.nlm.nih.gov/gene/614540", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F2Z4H8", "url": "https://www.orthodb.org/?gene=F2Z4H8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TKW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYG9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYG9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZF6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZF6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z4H8-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFALLPFSCSHSSPWEGLLFFFFRQGLLHLPRSYPCLERKRYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ", "length": 405, "header": "tr|F2Z4H8-1|F2Z4H8_BOVIN Isoform 1 of Nucleolysin TIAR OS=Bos taurus OX=9913 GN=TIAL1 PE=4 SV=4 CANONICAL=F2Z4H8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TKW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKW8/entry", "sequence": { "sequence": "MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ", "length": 392, "header": "tr|A0AAA9TKW8-1|F2Z4H8_BOVIN Computationally mapped isoform of Nucleolysin TIAR OS=Bos taurus OX=9913 GN=TIAL1 PE=4 SV=2 CANONICAL=F2Z4H8-1" }, "locus": { "chromosome": "26", "start_pos": 39717388, "end_pos": 39698405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090645.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090645.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097831.2" } ] } }, { "isoform_ac": "A0ABI0NYG9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG9/entry", "sequence": { "sequence": "MITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ", "length": 353, "header": "tr|A0ABI0NYG9-1|A0ABI0NYG9_BOVIN Computationally mapped isoform of TIA1 cytotoxic granule associated RNA binding protein like 1 OS=Bos taurus OX=9913 GN=TIAL1 PE=4 SV=1 CANONICAL=F2Z4H8-1" }, "locus": { "chromosome": "26", "start_pos": 39710585, "end_pos": 39698405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106482.1" } ] } }, { "isoform_ac": "A0ABI0NZF6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZF6/entry", "sequence": { "sequence": "MMEDDGQPRTLQGLLHLPRSYPCLERKRYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ", "length": 392, "header": "tr|A0ABI0NZF6-1|A0ABI0NZF6_BOVIN Computationally mapped isoform of Nucleolysin TIAR OS=Bos taurus OX=9913 GN=TIAL1 PE=4 SV=1 CANONICAL=F2Z4H8-1" }, "locus": { "chromosome": "26", "start_pos": 39717388, "end_pos": 39698405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137581.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137581.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105609.1" } ] } }, { "isoform_ac": "F2Z4H8-1", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8/entry", "sequence": { "sequence": "MFALLPFSCSHSSPWEGLLFFFFRQGLLHLPRSYPCLERKRYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ", "length": 405, "header": "tr|F2Z4H8-1|F2Z4H8_BOVIN Isoform 1 of Nucleolysin TIAR OS=Bos taurus OX=9913 GN=TIAL1 PE=4 SV=4 CANONICAL=F2Z4H8-1" }, "locus": { "chromosome": "26", "start_pos": 39715286, "end_pos": 39698405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005331.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005331.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005331.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005331.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "protein-RNA adaptor activity", "id": "GO:0140517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140517", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "cytolytic granule", "id": "GO:0044194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044194", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "positive regulation of miRNA-mediated gene silencing", "id": "GO:2000637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000637", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" }, { "name": "positive regulation of hippo signaling", "id": "GO:0035332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035332", "evidence": [ { "database": "UniProtKB", "id": "F2Z4H8", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F2Z4H8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 405, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F2Z4H8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F2Z4H8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F2Z4H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4H8" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 115, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 216, "end_pos": 218 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 234, "end_pos": 236 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4I6-1", "uniprot_ac": "F1N4I6", "uniprot_id": "F1N4I6_BOVIN", "mass": { "chemical_mass": 154238.0, "monoisotopic_mass": 154238.0 }, "refseq": {}, "gene_names": [ { "name": "ABCC11", "type": "recommended", "evidence": [ { "id": "F1N4I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ] } ], "protein_names": [ { "name": "ATP binding cassette subfamily C member 11", "type": "synonym", "evidence": [ { "id": "F1N4I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCC11", "url": "https://www.uniprot.org/uniprotkb/F1N4I6", "locus": { "chromosome": "18", "start_pos": 16589652, "end_pos": 16677760, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010858", "url": "https://www.ensembl.org/id/ENSBTAG00000010858" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010858", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010858", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18592", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18592", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18599", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18599", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF168", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF168", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TM94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4I6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4I6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRRRMYWVPRSSGGLVNLGLDVDDDMVSGLSYKTITVEDSPWRQQVREPEAPGRGKYDAAWKTMIPFRPKPKFPEPQPLDDAGLFSYLTLSWLNPLMVRGLRRSLDEDNIPQLSVHDAADKNAKRLRLLWEEEVSRHGIDKASVLRVMLRFQRTRLIFDTIVSCCFSITSVLGPILLMPKILEYAKNPSRDVAYGVGLCLALFFTECLKSLSMCSCWVINQRTGVRFRAAVFSFAFEKLMQFKSLTHITVGEAIGFFTTDVNCLYEGVYYGPLAVLTFLLLISCSITSCLVLGPIALIAMLCYLLFLPLQAFLTRKLVESQKHTSEVSDQRIRMTSVLTSIKLIKMYTWEKPFTKVIKDLRKKETKLLEKCGLIQSLTTVILFLAPSLSAVLLFLTHVGLRLKLTISVAFTTVATLGPMRLSVFLTPFAVKGLTNSKSAADRFKKFFLQESPVIYVKELEDPRKPVVLEEATLSWRKTCPGIINGALELEKNRYTPEGMTRAQPPLSGLEPEAQGDTRGPELRKINLVLSKGTMLGVCGNTGSGKSSLLSAILGQMHLLEGSVGVHGSLAYVPQQAWIIKGSVRENILMGSQYDEAWYLQVLHCCSLNHDLEILPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRELYLLDDPLSAVDAHVGKHIFEECFKKVLRRKTVILVTHQLQYLEFCDQIILFEDGKICEKGIHSELIQKRGRYAQLIQKMHEKATQGVLQGVAKTEEDLQLEGQAQTACQEELLSENAVLENQLSQKEKMEEGSLKWTVYHHYIQAGGGYLICSMIFLLMVMLAFFPVFSFWWLSYWLGQGSGNNSSQESNWTTADPGDILDNPQLPFYQLVFGLSGLLAILLGICLSLVFTKVMGKASTALHNKLFNKVSHCPMCFFDTTPTGRLLNCFAGDMDELDQFLPIMIEQSVLLVLAVIIILLIISFMSPYILLMGVVILSACLIYFRMFKKAINVFKRLKNYSCSPLFSHILTTLQGLSSIHVYGKTEEFINEFKKLTDVQNNYLLMFMSSTRWVALRLELMTNLVTLVVALFLVFGLSSVPHSYKAMAFSLVLQLASNFQASVRIGSEAEACLTAVERILQYMKMCVPEAPLHIEGASCPRGWPQHGEITFQDYQMKYRDNTPIVLNGLSLTIHSQEVVGIVGRTGSGKSSLGVALFRLVEPAGGRILIDGVDICSLSLEDLRSKFSVIPQDPVLLSGTIRFNLDPFHRCTDEQIWDALKRTFLNKTISKLPQGLQAEVTENGSNFSVGERQLLCIARALLRSSKIVLIDEATASLDLEMDILIQHVIRESFRGCTVLIIAHRVTTILNCDRILVMGNGKVVEFDKPEVLQRKPGSTFAALLAIASSSMS", "length": 1378, "header": "tr|F1N4I6-1|F1N4I6_BOVIN Isoform 1 of ATP binding cassette subfamily C member 11 OS=Bos taurus OX=9913 GN=ABCC11 PE=3 SV=4 CANONICAL=F1N4I6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TM94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM94/entry", "sequence": { "sequence": "MTRRRMYWVPRSSGGLVNLGLDVDDDMVSGLSYKTITVEDSPWRQQVREPEAPGRGKYDAAWKTMIPFRPKPKFPEPQPLDDAGLFSYLTLSWLNPLMVRGLRRSLDEDNIPQLSVHDAADKNAKRLRLLWEEEVSRHGIDKASVLRVMLRFQRTRLIFDTIVSCCFSITSVLGPILLMPKILEYAKNPSRDVAYGVGLCLALFFTECLKSLSMCSCWVINQRTGVRFRAAVFSFAFEKLMQFKSLTHITVGEAIGFFTTDVNCLYEGVYYGPLAVLTFLLLISCSITSCLVLGPIALIAMLCYLLFLPLQAFLTRKLVESQKHTSEVSDQRIRMTSVLTSIKLIKMYTWEKPFTKVIKDLRKKETKLLEKCGLIQSLTTVILFLAPSLSAVLLFLTHVGLRLKLTISVAFTTVATLGPMRLSVFLTPFAVKGLTNSKSAADRFKKFFLQESPVIYVKELEDPRKPVVLEEATLSWRKTCPGIINGALELEKNRYTPEGMTRAQPPLSGLEPEAQGDTRGPELRKINLVLSKGTMLGVCGNTGSGKSSLLSAILGQMHLLEGSVGVHGSLAYVPQQAWIIKGSVRENILMGSQYDEAWYLQVLHCCSLNHDLEILPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRELYLLDDPLSAVDAHVGKHIFEECFKKVLRRKTVILVTHQLQYLEFCDQIILFEDGKICEKGIHSELIQKRGRYAQLIQKMHEKATQGVLQGVAKTEEDLQLEGQAQTACQEELLSENAVLENQLSQKEKMEEGSLKWTVYHHYIQAGGGYLICSMIFLLMVMLAFFPVFSFWWLSYWLGQGSGNNSSQESNWTTADPGDILDNPQLPFYQLVFGLSGLLAILLGICLSLVFTKVMGKASTALHNKLFNKVSHCPMCFFDTTPTGRLLNCFAGDMDELDQFLPIMIEQSVLLVLAVIIILLIISFMSPYILLMGVVILSACLIYFRMFKKAINVFKRLKNYSCSPLFSHILTTLQGLSSIHVYGKTEEFINEFKKLTDVQNNYLLMFMSSTRWVALRLELMTNLVTLVVALFLVFGLSSVPHSYKAMAFSLVLQLASNFQASVRIGSEAEACLTAVERILQYMKMCVPEAPLHIEGASCPRGWPQHGEITFQDYQMKYRDNTPIVLNGLSLTIHSQEVVGIVGRTGSGKSSLGVALFRLVEPAGGRILIDGVDICSLSLEDLRSKFSVIPQDPVLLSGTIRFNLDPFHRCTDEQIWDALKRTFLNKTIVLIDEATASLDLEMDILIQHVIRESFRGCTVLIIAHRVTTILNCDRILVMGNGKVVEFDKPEVLQRKPGSTFAALLAIASSSMS", "length": 1340, "header": "tr|A0AAA9TM94-1|F1N4I6_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 11 OS=Bos taurus OX=9913 GN=ABCC11 PE=3 SV=1 CANONICAL=F1N4I6-1" }, "locus": { "chromosome": "18", "start_pos": 16667410, "end_pos": 16590656, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092718.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092718.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099501.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099501.1" } ] } }, { "isoform_ac": "F1N4I6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4I6/entry", "sequence": { "sequence": "MTRRRMYWVPRSSGGLVNLGLDVDDDMVSGLSYKTITVEDSPWRQQVREPEAPGRGKYDAAWKTMIPFRPKPKFPEPQPLDDAGLFSYLTLSWLNPLMVRGLRRSLDEDNIPQLSVHDAADKNAKRLRLLWEEEVSRHGIDKASVLRVMLRFQRTRLIFDTIVSCCFSITSVLGPILLMPKILEYAKNPSRDVAYGVGLCLALFFTECLKSLSMCSCWVINQRTGVRFRAAVFSFAFEKLMQFKSLTHITVGEAIGFFTTDVNCLYEGVYYGPLAVLTFLLLISCSITSCLVLGPIALIAMLCYLLFLPLQAFLTRKLVESQKHTSEVSDQRIRMTSVLTSIKLIKMYTWEKPFTKVIKDLRKKETKLLEKCGLIQSLTTVILFLAPSLSAVLLFLTHVGLRLKLTISVAFTTVATLGPMRLSVFLTPFAVKGLTNSKSAADRFKKFFLQESPVIYVKELEDPRKPVVLEEATLSWRKTCPGIINGALELEKNRYTPEGMTRAQPPLSGLEPEAQGDTRGPELRKINLVLSKGTMLGVCGNTGSGKSSLLSAILGQMHLLEGSVGVHGSLAYVPQQAWIIKGSVRENILMGSQYDEAWYLQVLHCCSLNHDLEILPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRELYLLDDPLSAVDAHVGKHIFEECFKKVLRRKTVILVTHQLQYLEFCDQIILFEDGKICEKGIHSELIQKRGRYAQLIQKMHEKATQGVLQGVAKTEEDLQLEGQAQTACQEELLSENAVLENQLSQKEKMEEGSLKWTVYHHYIQAGGGYLICSMIFLLMVMLAFFPVFSFWWLSYWLGQGSGNNSSQESNWTTADPGDILDNPQLPFYQLVFGLSGLLAILLGICLSLVFTKVMGKASTALHNKLFNKVSHCPMCFFDTTPTGRLLNCFAGDMDELDQFLPIMIEQSVLLVLAVIIILLIISFMSPYILLMGVVILSACLIYFRMFKKAINVFKRLKNYSCSPLFSHILTTLQGLSSIHVYGKTEEFINEFKKLTDVQNNYLLMFMSSTRWVALRLELMTNLVTLVVALFLVFGLSSVPHSYKAMAFSLVLQLASNFQASVRIGSEAEACLTAVERILQYMKMCVPEAPLHIEGASCPRGWPQHGEITFQDYQMKYRDNTPIVLNGLSLTIHSQEVVGIVGRTGSGKSSLGVALFRLVEPAGGRILIDGVDICSLSLEDLRSKFSVIPQDPVLLSGTIRFNLDPFHRCTDEQIWDALKRTFLNKTISKLPQGLQAEVTENGSNFSVGERQLLCIARALLRSSKIVLIDEATASLDLEMDILIQHVIRESFRGCTVLIIAHRVTTILNCDRILVMGNGKVVEFDKPEVLQRKPGSTFAALLAIASSSMS", "length": 1378, "header": "tr|F1N4I6-1|F1N4I6_BOVIN Isoform 1 of ATP binding cassette subfamily C member 11 OS=Bos taurus OX=9913 GN=ABCC11 PE=3 SV=4 CANONICAL=F1N4I6-1" }, "locus": { "chromosome": "18", "start_pos": 16667410, "end_pos": 16590656, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014417.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014417.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014417.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014417.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "ABC-type bile acid transporter activity", "id": "GO:0015432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015432", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "purine nucleotide transmembrane transporter activity", "id": "GO:0015216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015216", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "ABC-type glutathione S-conjugate transporter activity", "id": "GO:0015431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015431", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "bile acid and bile salt transport", "id": "GO:0015721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015721", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" }, { "name": "leukotriene transport", "id": "GO:0071716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071716", "evidence": [ { "database": "UniProtKB", "id": "F1N4I6", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1253, "end_pos": 1255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1270, "end_pos": 1272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1273, "end_pos": 1275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 629, "end_pos": 631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 833, "end_pos": 835, "annotation": "n_glycosylation_sequon" }, { "start_pos": 834, "end_pos": 836, "annotation": "n_glycosylation_sequon" }, { "start_pos": 840, "end_pos": 842, "annotation": "n_glycosylation_sequon" }, { "start_pos": 988, "end_pos": 990, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" }, { "id": "PS50929", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50929" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transmembrane type-1", "eco_id": "ECO_0000259", "start_pos": 158, "end_pos": 436, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I6" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 495, "end_pos": 728, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1253, "end_pos": 1255 }, { "start_pos": 1270, "end_pos": 1272 }, { "start_pos": 1273, "end_pos": 1275 }, { "start_pos": 629, "end_pos": 631 }, { "start_pos": 833, "end_pos": 835 }, { "start_pos": 834, "end_pos": 836 }, { "start_pos": 840, "end_pos": 842 }, { "start_pos": 988, "end_pos": 990 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2F1-1", "uniprot_ac": "F1N2F1", "uniprot_id": "F1N2F1_BOVIN", "mass": { "chemical_mass": 115069.0, "monoisotopic_mass": 115069.0 }, "refseq": {}, "gene_names": [ { "name": "NIBAN1", "type": "recommended", "evidence": [ { "id": "F1N2F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F1" } ] } ], "protein_names": [ { "name": "Niban apoptosis regulator 1", "type": "synonym", "evidence": [ { "id": "F1N2F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2F1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIBAN1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1", "locus": { "chromosome": "16", "start_pos": 65831761, "end_pos": 66013667, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014548", "url": "https://www.ensembl.org/id/ENSBTAG00000014548" } ] } } ], "crossref": [ { "id": "F1N2F1", "url": "https://alphafold.ebi.ac.uk/entry/F1N2F1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014548", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014548", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23949", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23949", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR026088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14392", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14392", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14392:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14392:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF26086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TNK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2F1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2F1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCNYPGENKKPAKRRKVLPDPTSPRAHPWSEGGKTAPGRPTDPQRARTRRRRPGRPRLSEEVCPLIAQPRSPSHQLPGAGSGRRRECPSLPPGQPRRSASSGTVTMGGSASSQLDESKCTYIRGKTEAAIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPLLEPGTVLYEGELLQFAEDIKKWKERYVVVKNDFAVESYENREAYQKGAPPKSRILPAGGKVLTSEDEYNLLSDRHFPDPIASNEKENMQPFVVLPKEFPVYLWQPFLRHGYFCFQDAADQKKFSALLSDCIRHLNHDYMKQTTFEAQAFLEAVQFFRQEKGHYGSWEMVTGDEVQILSNLVMEELMPTLQTDILPKMKGKKNDRKRAWFGLLEEAYHLVQHRVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNFLIGKIKAMVAQPAERSCAESVQPFLGSILEELMGPVSSGFSELRSLFEKEVDELSQSFQTTKDSAQLKEHLEQLMDLPLDSVKMEPCYNKVNLLQEHLQDLKSRFRFPHIDLVVQRTQNYMQELMENAIFTFEQLLSPHLQGEASKTTVAIEKVKLRVLKQYDYDSSTIRKRIFQEALVQITLPTLQKALASVCKPELQKYEQYIFADHTNMIHVENVYEEILHQILLDESLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKTPAGSNQASPARRASAVLPGVSESEILSNEVFQEAGEMKQPEVPSPLAREEGLSLPVSSPPPDGDRQVIDSSIDGPVVNLVATEVTAGALGTHLSQPELEETPEDREPTQEDAEPRSAAGSLKELRNLLTVTAEVTGESAVLEVEKDTHEEALVPQDIEKEEEATQIDTEASQASASGQDNCEESEVGEGEAHGPTPKAEASGVELGEFPDAQPTCGGLSEGARGPDPTEEPGEAGELTESELTGDASGLGTLEGGGPVCSVEAEAVSLEACVFRSDSISPRESQVSVEEEAVGGSCSTAQPATSEDAQERKADPVHECQWVVENVANTDTLDTQREDPPEPPSEE", "length": 1038, "header": "tr|F1N2F1-1|F1N2F1_BOVIN Isoform 1 of Niban apoptosis regulator 1 OS=Bos taurus OX=9913 GN=NIBAN1 PE=1 SV=3 CANONICAL=F1N2F1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TNK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNK2/entry", "sequence": { "sequence": "MYFSSVTPLTRPNNWKSLLPANRGPLTDCMLCKRKTEAAIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPLLEPGTVLYEGELLQFAEDIKKWKERYVVVKNDFAVESYENREAYQKGAPPKSRILPAGGKVLTSEDEYNLLSDRHFPDPIASNEKENMQPFVVLPKEFPVYLWQPFLRHGYFCFQDAADQKKFSALLSDCIRHLNHDYMKQTTFEAQAFLEAVQFFRQEKGHYGSWEMVTGDEVQILSNLVMEELMPTLQTDILPKMKGKKNDRKRAWFGLLEEAYHLVQHRVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNFLIGKIKAMVAQPAERSCAESVQPFLGSILEELMGPVSSGFSELRSLFEKEVDELSQSFQTTKDSAQLKEHLEQLMDLPLDSVKMEPCYNKVNLLQEHLQDLKSRFRFPHIDLVVQRTQNYMQELMENAIFTFEQLLSPHLQGEASKTTVAIEKVKLRVLKQYDYDSSTIRKRIFQEALVQITLPTLQKALASVCKPELQKYEQYIFADHTNMIHVENVYEEILHQILLDESLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKTPAGSNQASPARRASAVLPGVSESEILSNEVFQEAGEMKQPEVPSPLAREEGLSLPVSSPPPDGDRQVIDSSIDGPVVNLVATEVTAGALGTHLSQPELEETPEDREPTQEDAEPRSAAGSLKELRNLLTVTAEVTGESAVLEVEKDTHEEALVPQDIEKEEEATQIDTEASQASASGQDNCEESEVGEGEAHGPTPKAEASGVELGEFPDAQPTCGGLSEGARGPDPTEEPGEAGELTESELTGDASGLGTLEGGGPVCSVEAEAVSLEACVFRSDSISPRESQVSVEEEAVGGSCSTAQPATSEDAQERKADPVHECQWVVENVANTDTLDTQREDPPEPPSEE", "length": 948, "header": "tr|A0AAA9TNK2-1|F1N2F1_BOVIN Computationally mapped isoform of Niban apoptosis regulator 1 OS=Bos taurus OX=9913 GN=NIBAN1 PE=1 SV=1 CANONICAL=F1N2F1-1" }, "locus": { "chromosome": "16", "start_pos": 65943349, "end_pos": 65831842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119780.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119780.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098607.1" } ] } }, { "isoform_ac": "A0AAA9TV81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV81/entry", "sequence": { "sequence": "MCNYPGKTEAAIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPLLEPGTVLYEGELLQFAEDIKKWKERYVVVKNDFAVESYENREAYQKGAPPKSRILPAGGKVLTSEDEYNLLSDRHFPDPIASNEKENMQPFVVLPKEFPVYLWQPFLRHGYFCFQDAADQKKFSALLSDCIRHLNHDYMKQTTFEAQAFLEAVQFFRQEKGHYGSWEMVTGDEVQILSNLVMEELMPTLQTDILPKMKGKKNDRKRAWFGLLEEAYHLVQHRVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNFLIGKIKAMVAQPAERSCAESVQPFLGSILEELMGPVSSGFSELRSLFEKEVDELSQSFQTTKDSAQLKEHLEQLMDLPLDSVKMEPCYNKVNLLQEHLQDLKSRFRFPHIDLVVQRTQNYMQELMENAIFTFEQLLSPHLQGEASKTTVAIEKVKLRVLKQYDYDSSTIRKRIFQEALVQITLPTLQKALASVCKPELQKYEQYIFADHTNMIHVENVYEEILHQILLDESLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKTPAGSNQASPARRASAVLPGVSESEILSNEVFQEAGEMKQPEVPSPLAREEGLSLPVSSPPPDGDRQVIDSSIDGPVVNLVATEVTAGALGTHLSQPELEETPEDREPTQEDAEPRSAAGSLKELRNLLTVTAEVTGESAVLEVEKDTHEEALVPQDIEKEEEATQIDTEASQASASGQDNCEESEVGEGEAHGPTPKAEASGVELGEFPDAQPTCGGLSEGARGPDPTEEPGEAGELTESELTGDASGLGTLEGGGPVCSVEAEAVSLEACVFRSDSISPRESQVSVEEEAVGGSCSTAQPATSEDAQERKADPVHECQWVVENVANTDTLDTQREDPPEPPSEE", "length": 920, "header": "tr|A0AAA9TV81-1|F1N2F1_BOVIN Computationally mapped isoform of Niban apoptosis regulator 1 OS=Bos taurus OX=9913 GN=NIBAN1 PE=1 SV=1 CANONICAL=F1N2F1-1" }, "locus": { "chromosome": "16", "start_pos": 66013493, "end_pos": 65831842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125388.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125388.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102270.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102270.1" } ] } }, { "isoform_ac": "F1N2F1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1/entry", "sequence": { "sequence": "MCNYPGENKKPAKRRKVLPDPTSPRAHPWSEGGKTAPGRPTDPQRARTRRRRPGRPRLSEEVCPLIAQPRSPSHQLPGAGSGRRRECPSLPPGQPRRSASSGTVTMGGSASSQLDESKCTYIRGKTEAAIKNFSPYYSRQYSVAFCNHVRSEVEQQRDLTSQFLKTKPLLEPGTVLYEGELLQFAEDIKKWKERYVVVKNDFAVESYENREAYQKGAPPKSRILPAGGKVLTSEDEYNLLSDRHFPDPIASNEKENMQPFVVLPKEFPVYLWQPFLRHGYFCFQDAADQKKFSALLSDCIRHLNHDYMKQTTFEAQAFLEAVQFFRQEKGHYGSWEMVTGDEVQILSNLVMEELMPTLQTDILPKMKGKKNDRKRAWFGLLEEAYHLVQHRVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNFLIGKIKAMVAQPAERSCAESVQPFLGSILEELMGPVSSGFSELRSLFEKEVDELSQSFQTTKDSAQLKEHLEQLMDLPLDSVKMEPCYNKVNLLQEHLQDLKSRFRFPHIDLVVQRTQNYMQELMENAIFTFEQLLSPHLQGEASKTTVAIEKVKLRVLKQYDYDSSTIRKRIFQEALVQITLPTLQKALASVCKPELQKYEQYIFADHTNMIHVENVYEEILHQILLDESLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKTPAGSNQASPARRASAVLPGVSESEILSNEVFQEAGEMKQPEVPSPLAREEGLSLPVSSPPPDGDRQVIDSSIDGPVVNLVATEVTAGALGTHLSQPELEETPEDREPTQEDAEPRSAAGSLKELRNLLTVTAEVTGESAVLEVEKDTHEEALVPQDIEKEEEATQIDTEASQASASGQDNCEESEVGEGEAHGPTPKAEASGVELGEFPDAQPTCGGLSEGARGPDPTEEPGEAGELTESELTGDASGLGTLEGGGPVCSVEAEAVSLEACVFRSDSISPRESQVSVEEEAVGGSCSTAQPATSEDAQERKADPVHECQWVVENVANTDTLDTQREDPPEPPSEE", "length": 1038, "header": "tr|F1N2F1-1|F1N2F1_BOVIN Isoform 1 of Niban apoptosis regulator 1 OS=Bos taurus OX=9913 GN=NIBAN1 PE=1 SV=3 CANONICAL=F1N2F1-1" }, "locus": { "chromosome": "16", "start_pos": 66013493, "end_pos": 65831842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019338.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019338.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019338.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019338.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N2F1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "F1N2F1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "F1N2F1", "url": "https://www.uniprot.org/uniprotkb/F1N2F1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2F1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1038, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2F1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2F1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F1" }, { "id": "PF26086", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Niban 1/2/3", "eco_id": "ECO_0000259", "start_pos": 443, "end_pos": 611, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N338-1", "uniprot_ac": "F1N338", "uniprot_id": "F1N338_BOVIN", "mass": { "chemical_mass": 34391.0, "monoisotopic_mass": 34391.0 }, "refseq": {}, "gene_names": [ { "name": "HADH", "type": "recommended", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] } ], "protein_names": [ { "name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "type": "recommended", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.35", "type": "synonym", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338/entry#names_and_taxonomy" } ] }, { "name": "Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase", "type": "synonym", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338/entry#names_and_taxonomy" } ] }, { "name": "Short-chain 3-hydroxyacyl-CoA dehydrogenase", "type": "synonym", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes.", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338#function" }, { "database": "UniProtKB", "id": "ARBA00059837", "url": "https://www.uniprot.org/uniprotkb/ARBA00059837#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HADH", "url": "https://www.uniprot.org/uniprotkb/F1N338", "locus": { "chromosome": "6", "start_pos": 17208776, "end_pos": 17252208, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002049", "url": "https://www.ensembl.org/id/ENSBTAG00000002049" } ] } } ], "crossref": [ { "id": "F1N338", "url": "https://alphafold.ebi.ac.uk/entry/F1N338", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002049", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002049", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MAHPMGP", "url": "https://omabrowser.org/oma/group/MAHPMGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N338", "url": "https://www.orthodb.org/?gene=F1N338", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43561", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43561", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43561:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43561:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00725", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00725", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-77310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77346", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77346", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77348", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77348", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77350", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77350", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77352", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77352", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "22432", "url": "https://www.rhea-db.org/rhea/22432", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "30799", "url": "https://www.rhea-db.org/rhea/30799", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "31159", "url": "https://www.rhea-db.org/rhea/31159", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "31187", "url": "https://www.rhea-db.org/rhea/31187", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TPP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N338-1", "url": "https://www.uniprot.org/uniprotkb/F1N338-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFVTRQFVRSMSSSSSAAASAKKILVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILEKSRKGIEESLRKVAKKKFAENPKGADEFVAKTLSSISTSTDAASVVHSTDLVVEAIVENLQMKNELFKRLDKFAAEHTIFASNTSSLQITSLANSTTRQDRFAGLHFFNPVPLMKLVEVIKTPMTSQKTFESLLDFSRALGKHPVACKDTPGFIVNRLLVPYLMEAVRLCERGEASKEDIDMAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDSKNPLFQPCPSLNKLVAEKKFGKKSGEGFYKYK", "length": 314, "header": "tr|F1N338-1|F1N338_BOVIN Isoform 1 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=HADH PE=3 SV=1 CANONICAL=F1N338-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TPP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPP3/entry", "sequence": { "sequence": "MAFVTRQFVRSMSSSSSAAASAKKILVKHVTVIGGGLMGAGIAQVIKTPMTSQKTFESLLDFSRALGKHPVACKDTPGFIVNRLLVPYLMEAVRLCERGEASKEDIDMAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDSKNPLFQPCPSLNKLVAEKKFGKKSGEGFYKYK", "length": 176, "header": "tr|A0AAA9TPP3-1|F1N338_BOVIN Computationally mapped isoform of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=HADH PE=3 SV=1 CANONICAL=F1N338-1" }, "locus": { "chromosome": "6", "start_pos": 17252106, "end_pos": 17209499, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122435.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122435.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099251.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099251.1" } ] } }, { "isoform_ac": "F1N338-1", "url": "https://www.uniprot.org/uniprotkb/F1N338/entry", "sequence": { "sequence": "MAFVTRQFVRSMSSSSSAAASAKKILVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILEKSRKGIEESLRKVAKKKFAENPKGADEFVAKTLSSISTSTDAASVVHSTDLVVEAIVENLQMKNELFKRLDKFAAEHTIFASNTSSLQITSLANSTTRQDRFAGLHFFNPVPLMKLVEVIKTPMTSQKTFESLLDFSRALGKHPVACKDTPGFIVNRLLVPYLMEAVRLCERGEASKEDIDMAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDSKNPLFQPCPSLNKLVAEKKFGKKSGEGFYKYK", "length": 314, "header": "tr|F1N338-1|F1N338_BOVIN Isoform 1 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=HADH PE=3 SV=1 CANONICAL=F1N338-1" }, "locus": { "chromosome": "6", "start_pos": 17252106, "end_pos": 17209499, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002654.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002654.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002654.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002654.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-77310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77310", "resource": "Reactome", "description": "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" }, { "id": "R-BTA-77346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77346", "resource": "Reactome", "description": "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" }, { "id": "R-BTA-77348", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77348", "resource": "Reactome", "description": "Beta oxidation of octanoyl-CoA to hexanoyl-CoA" }, { "id": "R-BTA-77350", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77350", "resource": "Reactome", "description": "Beta oxidation of hexanoyl-CoA to butanoyl-CoA" }, { "id": "R-BTA-77352", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77352", "resource": "Reactome", "description": "Beta oxidation of butanoyl-CoA to acetyl-CoA" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XIM8-1", "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "HADH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAVGRPFLGASVALRNGRRRFEFGSGGSSGLMSPSVRCVCVRVVLLPVTPALLPERERPPRPPAVRGRRGGGRCCSAAVAQLPRRQEEPSSVFYVVEMAFRTKHGLLISQKVAAASGHTVVLVDQSDEILKKSTKGIEESLKRVTKKKFADKPEAGAEFIEKTLKNLTTSTDAVAVVHSTDLVIEAIVENQEIKSELFKRLDKFAPEHTIFTSNTSSLQITQLANSTTRQDRFGGLHFFNPVPMMKLVEVVKTPMTSQKTYESLMDFSKAVGKSPVSCKDTPGFIVNRLLVPYMMEAVRLFERGDASKEDIDVAMKLGAGYPMGPFELLDYVGLDTSKYIIDGWHAIEPNNPLFLPSPLLDKLVEEKKLGRKTGEGFYKYN", "length": 382 }, "evidence": [ { "id": "F1N338", "url": "https://omabrowser.org/oma/group/F1N338/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P00348-1", "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "HADH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFATRQLVRSLSSSSTAAASAKKILVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSSISTSTDAASVVHSTDLVVEAIVENLKVKSELFKRLDKFAAEHTIFASNTSSLQITSLANATTRQDRFAGLHFFNPVPLMKLVEVVKTPMTSQKTLESLVDFSKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIIDGWHEMDSQNPLFQPSPAMNKLVAENKFGKKTGEGFYKYK", "length": 314 }, "evidence": [ { "id": "F1N338", "url": "https://omabrowser.org/oma/group/F1N338/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q16836-1", "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "HADH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK", "length": 314 }, "evidence": [ { "id": "F1N338", "url": "https://omabrowser.org/oma/group/F1N338/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61425-1", "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "Hadh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFVTRQFLRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK", "length": 314 }, "evidence": [ { "id": "F1N338", "url": "https://omabrowser.org/oma/group/F1N338/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LDF5-1", "protein_name": "3-hydroxyacyl-CoA dehydrogenase family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEMKSVGVVGAGQMGSGIAQLAATSGLDVWLMDADRDALSRATAAISSSVKRFVSKGLISKEVGDDAMHRLRLTSNLEDLCSADIIVEAIVESEDIKKKLFKDLDGIAKSSAILASNTSSISITRLASATRRPSQVIGMHFMNPPPIMKLVEIIRGADTSEETFLATKVLAERFGKTTVCSQDYAGFVVNRILMPMINEAFHTLYTGVATKEDIDSGMKHGTNHPMGPLELADLIGLDVCLSVMKVLHEGLGDSKYAPCPLLVQYVDAGRLGRKRGVGVYDYREATQKLSPRL", "length": 294 }, "evidence": [ { "id": "F1N338", "url": "https://omabrowser.org/oma/group/F1N338/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9WVK7-1", "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "Hadh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFVTRQFVRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAADEFVEKTLSSLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK", "length": 314 }, "evidence": [ { "id": "F1N338", "url": "https://omabrowser.org/oma/group/F1N338/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "id": "GO:0003857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003857", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" }, { "name": "NAD+ binding", "id": "GO:0070403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070403", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "F1N338", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22432", "name": "", "equation": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0AAA9SND8-1", "O02691-1", "A0A3Q1LS03-1", "A0AAA9RY48-1" ], "evidence": [ { "id": "22432", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22432" } ] }, { "id": "30799", "name": "", "equation": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O02691-1", "A0AAA9RY48-1", "A0A3Q1LS03-1", "F1N338-1" ], "evidence": [ { "id": "30799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30799" } ] }, { "id": "31159", "name": "", "equation": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SND8-1", "O02691-1", "A0A3Q1NDR1-1", "A0AAA9RY48-1", "A0A3Q1LS03-1", "F1N338-1" ], "evidence": [ { "id": "31159", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31159" } ] }, { "id": "31187", "name": "", "equation": "(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SND8-1", "A0A3Q1NDR1-1", "A0A3Q1LS03-1", "F1N338-1" ], "evidence": [ { "id": "31187", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31187" } ] }, { "id": "R-BTA-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77252" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77254", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77254" } ] }, { "id": "R-BTA-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77251" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77312", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77312" } ] }, { "id": "R-BTA-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77322" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77323", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77323" } ] }, { "id": "R-BTA-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77330" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77331", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77331" } ] }, { "id": "R-BTA-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77341" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77342" } ] }, { "id": "R-BTA-9838035", "name": "CLPXP binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838035", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838035" } ] }, { "id": "R-BTA-9838081", "name": "LONP1 degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838081" } ] }, { "id": "R-BTA-9838093", "name": "LONP1 binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838093", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838093" } ] }, { "id": "R-BTA-9838289", "name": "CLPXP degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838289", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838289" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-77251", "participant_name": "3HB-CoA [mitochondrial matrix]", "crossref": [ { "id": "57316", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551316", "database": "ZINC", "url": "" }, { "id": "C01144", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77252", "participant_name": "(S)-3-Hydroxydodecanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62558", "database": "ChEBI", "url": "" }, { "id": "ZINC000195755502", "database": "ZINC", "url": "" }, { "id": "C05262", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77322", "participant_name": "(S)-Hydroxyhexanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62075", "database": "ChEBI", "url": "" }, { "id": "ZINC000096014539", "database": "ZINC", "url": "" }, { "id": "C05268", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77330", "participant_name": "(S)-Hydroxyoctanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62617", "database": "ChEBI", "url": "" }, { "id": "ZINC000096085226", "database": "ZINC", "url": "" }, { "id": "C05266", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77341", "participant_name": "(S)-Hydroxydecanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62616", "database": "ChEBI", "url": "" }, { "id": "ZINC000096014970", "database": "ZINC", "url": "" }, { "id": "C05264", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T871", "gene_name": "GLUD1", "activity": [ { "ec_number": "1.4.1.3", "activity": "L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+).", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] }, { "ec_number": "1.4.1.3", "activity": "", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] } ] }, { "uniprot_ac": "A0A3Q1LR42", "gene_name": "NADK2", "activity": [ { "ec_number": "2.7.1.23", "activity": "NAD(+) + ATP = ADP + NADP(+) + H(+).", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] }, { "ec_number": "2.7.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] } ] }, { "uniprot_ac": "A0A3Q1LS03", "gene_name": "", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LYU1", "gene_name": "PDK1", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1LYU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ] } ] }, { "uniprot_ac": "A0A3Q1NDR1", "gene_name": "HADHA", "activity": [ { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] }, { "ec_number": "1.1.1.211", "activity": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] }, { "ec_number": "1.1.1.211", "activity": "", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] } ] }, { "uniprot_ac": "A0AAA9RY48", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.53", "activity": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.159", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.178", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] } ] }, { "uniprot_ac": "A0AAA9S896", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] } ] }, { "uniprot_ac": "A0AAA9SND8", "gene_name": "EHHADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] } ] }, { "uniprot_ac": "A6QLI6", "gene_name": "ALAS1", "activity": [ { "ec_number": "2.3.1.37", "activity": "succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA.", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] }, { "ec_number": "2.3.1.37", "activity": "", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] } ] }, { "uniprot_ac": "A7MB35", "gene_name": "PDHA1", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] } ] }, { "uniprot_ac": "F1MTT7", "gene_name": "ECI1", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] } ] }, { "uniprot_ac": "F1MXW5", "gene_name": "OXSM", "activity": [ { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2.", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N206", "gene_name": "DLD", "activity": [ { "ec_number": "1.8.1.4", "activity": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+).", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] } ] }, { "uniprot_ac": "F1N338", "gene_name": "HADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] } ] }, { "uniprot_ac": "G3MWG4", "gene_name": "IARS2", "activity": [ { "ec_number": "6.1.1.5", "activity": "tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate.", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] }, { "ec_number": "6.1.1.5", "activity": "", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] } ] }, { "uniprot_ac": "G3MWN1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] } ] }, { "uniprot_ac": "G3N0R5", "gene_name": "HSPD1", "activity": [ { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] } ] }, { "uniprot_ac": "O02691", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.53", "activity": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] } ] }, { "uniprot_ac": "P00829", "gene_name": "ATP5F1B", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out).", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] } ] }, { "uniprot_ac": "P11181", "gene_name": "DBT", "activity": [ { "ec_number": "2.3.1.168", "activity": "(2S)-2-methylbutanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CoA.", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.168", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] } ] }, { "uniprot_ac": "P11966", "gene_name": "PDHB", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P20000", "gene_name": "ALDH2", "activity": [ { "ec_number": "1.2.1.3", "activity": "acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+).", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] } ] }, { "uniprot_ac": "P20004", "gene_name": "ACO2", "activity": [ { "ec_number": "4.2.1.3", "activity": "citrate = D-threo-isocitrate.", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] }, { "ec_number": "4.2.1.3", "activity": "", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] } ] }, { "uniprot_ac": "P22600", "gene_name": "FECH", "activity": [ { "ec_number": "4.98.1.1", "activity": "heme b + 2 H(+) = protoporphyrin IX + Fe(2+).", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] }, { "ec_number": "4.98.1.1", "activity": "", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] } ] }, { "uniprot_ac": "Q02337", "gene_name": "BDH1", "activity": [ { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] }, { "ec_number": "1.1.1.30", "activity": "", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] } ] }, { "uniprot_ac": "Q04467", "gene_name": "IDH2", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "Q04467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q04467" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "Q04467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q04467" } ] } ] }, { "uniprot_ac": "Q0NXR6", "gene_name": "ACAD8", "activity": [ { "ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] } ] }, { "uniprot_ac": "Q148N0", "gene_name": "OGDH", "activity": [ { "ec_number": "1.2.4.2", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] } ] }, { "uniprot_ac": "Q29RK1", "gene_name": "CS", "activity": [ { "ec_number": "2.3.3.1", "activity": "oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+).", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] }, { "ec_number": "2.3.3.1", "activity": "", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] } ] }, { "uniprot_ac": "Q29RZ0", "gene_name": "ACAT1", "activity": [ { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] }, { "ec_number": "2.3.1.9", "activity": "", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] } ] }, { "uniprot_ac": "Q2KHU4", "gene_name": "CLPP", "activity": [ { "ec_number": "3.4.21.92", "activity": "Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).", "evidence": [ { "id": "Q2KHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU4" } ] }, { "ec_number": "3.4.21.92", "activity": "", "evidence": [ { "id": "Q2KHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU4" } ] } ] }, { "uniprot_ac": "Q2KIE6", "gene_name": "HMGCS2", "activity": [ { "ec_number": "2.3.3.10", "activity": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).", "evidence": [ { "id": "Q2KIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIE6" } ] }, { "ec_number": "2.3.3.10", "activity": "", "evidence": [ { "id": "Q2KIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIE6" } ] } ] }, { "uniprot_ac": "Q2TBR0", "gene_name": "PCCB", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] } ] }, { "uniprot_ac": "Q32LG3", "gene_name": "MDH2", "activity": [ { "ec_number": "1.1.1.37", "activity": "(S)-malate + NAD(+) = oxaloacetate + NADH + H(+).", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] }, { "ec_number": "1.1.1.37", "activity": "", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] } ] }, { "uniprot_ac": "Q3MHX5", "gene_name": "SUCLG2", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] }, { "ec_number": "6.2.1.4", "activity": "itaconate + GTP + CoA = itaconyl-CoA + GDP + phosphate.", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] }, { "ec_number": "6.2.1.4", "activity": "", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q5EAD4", "gene_name": "ACADSB", "activity": [ { "ec_number": "1.3.8.1", "activity": "a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] }, { "ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] }, { "ec_number": "1.3.8.1", "activity": "", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N338-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N338-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N338" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" }, { "id": "PF00725", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00725" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3-hydroxyacyl-CoA dehydrogenase C-terminal", "eco_id": "ECO_0000259", "start_pos": 216, "end_pos": 313, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" }, { "id": "PF02737", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02737" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "3-hydroxyacyl-CoA dehydrogenase NAD binding", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 214, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.35", "ec_name": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "1.1.1.35", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35" }, { "id": "1.1.1.35", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.35" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 }, { "start_pos": 158, "end_pos": 160 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N547-1", "uniprot_ac": "F1N547", "uniprot_id": "F1N547_BOVIN", "mass": { "chemical_mass": 19563.0, "monoisotopic_mass": 19563.0 }, "refseq": {}, "gene_names": [ { "name": "CETN3", "type": "recommended", "evidence": [ { "id": "F1N547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ] } ], "protein_names": [ { "name": "Centrin-3", "type": "recommended", "evidence": [ { "id": "F1N547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N547/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547#function" }, { "database": "UniProtKB", "id": "ARBA00060271", "url": "https://www.uniprot.org/uniprotkb/ARBA00060271#function" } ] }, { "annotation": "Plays a fundamental role in microtubule-organizing center structure and function.", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547#function" }, { "database": "UniProtKB", "id": "ARBA00056666", "url": "https://www.uniprot.org/uniprotkb/ARBA00056666#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CETN3", "url": "https://www.uniprot.org/uniprotkb/F1N547", "locus": { "chromosome": "7", "start_pos": 89936061, "end_pos": 89953545, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014373", "url": "https://www.ensembl.org/id/ENSBTAG00000014373" } ] } } ], "crossref": [ { "id": "F1N547", "url": "https://alphafold.ebi.ac.uk/entry/F1N547", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014373", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014373", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFFMIMK", "url": "https://omabrowser.org/oma/group/EFFMIMK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N547", "url": "https://www.orthodb.org/?gene=F1N547", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TR26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N547-1", "url": "https://www.uniprot.org/uniprotkb/F1N547-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLALRNDLVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI", "length": 167, "header": "tr|F1N547-1|F1N547_BOVIN Isoform 1 of Centrin-3 OS=Bos taurus OX=9913 GN=CETN3 PE=3 SV=1 CANONICAL=F1N547-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TR26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR26/entry", "sequence": { "sequence": "MSLALRNDLVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVGVYFKSLCNQQLLGNYLDTISI", "length": 111, "header": "tr|A0AAA9TR26-1|F1N547_BOVIN Computationally mapped isoform of Centrin-3 OS=Bos taurus OX=9913 GN=CETN3 PE=3 SV=1 CANONICAL=F1N547-1" }, "locus": { "chromosome": "7", "start_pos": 89953462, "end_pos": 89949338, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103326.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103326.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100819.1" } ] } }, { "isoform_ac": "F1N547-1", "url": "https://www.uniprot.org/uniprotkb/F1N547/entry", "sequence": { "sequence": "MSLALRNDLVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI", "length": 167, "header": "tr|F1N547-1|F1N547_BOVIN Isoform 1 of Centrin-3 OS=Bos taurus OX=9913 GN=CETN3 PE=3 SV=1 CANONICAL=F1N547-1" }, "locus": { "chromosome": "7", "start_pos": 89953462, "end_pos": 89936418, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019111.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019111.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019111.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019111.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QWN4-1", "protein_name": "Centrin 3", "gene_name": "CETN3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLALRNELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADILKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINFSKTKLFSRFFANYLM", "length": 171 }, "evidence": [ { "id": "F1N547", "url": "https://omabrowser.org/oma/group/F1N547/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HL74-1", "protein_name": "Centrin-3", "gene_name": "Cetn3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDHAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI", "length": 167 }, "evidence": [ { "id": "F1N547", "url": "https://omabrowser.org/oma/group/F1N547/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0RCW6-1", "protein_name": "Centrin-3", "gene_name": "Cetn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "RGGRASVPQRGQGGRGREAESGADEECRASDLGGPRLPQRRSPSEVSRGFPHASAGFGPGRLLPPESHRRARLSARVPWHAVLWASWVDLVSVTPSSHFRTSPLPIGSSPCPSTLKGAPGPRISLGGELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDQAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI", "length": 287 }, "evidence": [ { "id": "F1N547", "url": "https://omabrowser.org/oma/group/F1N547/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15182-1", "protein_name": "Centrin-3", "gene_name": "CETN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI", "length": 167 }, "evidence": [ { "id": "F1N547", "url": "https://omabrowser.org/oma/group/F1N547/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35648-1", "protein_name": "Centrin-3", "gene_name": "Cetn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLALRGELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDQAIDYHELKVAMRALGFDVKKADVLKILKDYDREATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI", "length": 167 }, "evidence": [ { "id": "F1N547", "url": "https://omabrowser.org/oma/group/F1N547/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P06704-1", "protein_name": "Cell division control protein 31", "gene_name": "CDC31", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKNRSSLQSGPLNSELLEEQKQEIYEAFSLFDMNNDGFLDYHELKVAMKALGFELPKREILDLIDEYDSEGRHLMKYDDFYIVMGEKILKRDPLDEIKRAFQLFDDDHTGKISIKNLRRVAKELGETLTDEELRAMIEEFDLDGDGEINENEFIAICTDS", "length": 161 }, "evidence": [ { "id": "F1N547", "url": "https://omabrowser.org/oma/group/F1N547/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "G-protein beta/gamma-subunit complex binding", "id": "GO:0031683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031683", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nuclear pore nuclear basket", "id": "GO:0044615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044615", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "transcription export complex 2", "id": "GO:0070390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070390", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "F1N547", "url": "https://www.uniprot.org/uniprotkb/F1N547" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N547-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 167, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N547-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N547" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N547" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 60, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F6QJJ8-1", "uniprot_ac": "F6QJJ8", "uniprot_id": "F6QJJ8_BOVIN", "mass": { "chemical_mass": 26062.0, "monoisotopic_mass": 26062.0 }, "refseq": {}, "gene_names": [ { "name": "PGRMC2", "type": "recommended", "evidence": [ { "id": "F6QJJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ] } ], "protein_names": [ { "name": "Membrane-associated progesterone receptor component 1", "type": "recommended", "evidence": [ { "id": "F6QJJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization.", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8#function" }, { "database": "UniProtKB", "id": "ARBA00053089", "url": "https://www.uniprot.org/uniprotkb/ARBA00053089#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGRMC2", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8", "locus": { "chromosome": "17", "start_pos": 29478964, "end_pos": 29460237, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010843", "url": "https://www.ensembl.org/id/ENSBTAG00000010843" } ] } } ], "crossref": [ { "id": "F6QJJ8", "url": "https://alphafold.ebi.ac.uk/entry/F6QJJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010843", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010843", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QNTIEAD", "url": "https://omabrowser.org/oma/group/QNTIEAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6QJJ8", "url": "https://www.orthodb.org/?gene=F6QJJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10281", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10281", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10281:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10281:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00173", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00173", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707616", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TU38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QJJ8-1", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGAGRGVGEGRGRGGGGRRWRAVMAAGDGDVNLGTLGSGSESSSDGSSESPGGAGAAAEGGSCLATALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPAASLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALKDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD", "length": 247, "header": "tr|F6QJJ8-1|F6QJJ8_BOVIN Isoform 1 of Membrane-associated progesterone receptor component 1 OS=Bos taurus OX=9913 GN=PGRMC2 PE=1 SV=1 CANONICAL=F6QJJ8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TU38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU38/entry", "sequence": { "sequence": "MQILINNAGPYGIFAGRDASRGLATFCLDKDALKDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD", "length": 91, "header": "tr|A0AAA9TU38-1|F6QJJ8_BOVIN Computationally mapped isoform of Membrane-associated progesterone receptor component 1 OS=Bos taurus OX=9913 GN=PGRMC2 PE=1 SV=1 CANONICAL=F6QJJ8-1" }, "locus": { "chromosome": "17", "start_pos": 29477804, "end_pos": 29461589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101808.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101808.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100611.1" } ] } }, { "isoform_ac": "F6QJJ8-1", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8/entry", "sequence": { "sequence": "MGGAGRGVGEGRGRGGGGRRWRAVMAAGDGDVNLGTLGSGSESSSDGSSESPGGAGAAAEGGSCLATALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPAASLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALKDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD", "length": 247, "header": "tr|F6QJJ8-1|F6QJJ8_BOVIN Isoform 1 of Membrane-associated progesterone receptor component 1 OS=Bos taurus OX=9913 GN=PGRMC2 PE=1 SV=1 CANONICAL=F6QJJ8-1" }, "locus": { "chromosome": "17", "start_pos": 29477804, "end_pos": 29460436, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014390.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014390.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014390.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014390.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" }, { "id": "R-BTA-9707616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707616", "resource": "Reactome", "description": "Heme signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "O15173-1", "protein_name": "Membrane-associated progesterone receptor component 2", "gene_name": "PGRMC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGDGDVKLGTLGSGSESSNDGGSESPGDAGAAAEGGGWAAAALALLTGGGEMLLNVALVALVLLGAYRLWVRWGRRGLGAGAGAGEESPATSLPRMKKRDFSLEQLRQYDGSRNPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHNKQD", "length": 223 }, "evidence": [ { "id": "F6QJJ8", "url": "https://omabrowser.org/oma/group/F6QJJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5XIU9-1", "protein_name": "Membrane-associated progesterone receptor component 2", "gene_name": "Pgrmc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGDGDVKLSTLGSGGERGGDGSPGGAGATAARSSWVAALLATGGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQLRQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD", "length": 217 }, "evidence": [ { "id": "F6QJJ8", "url": "https://omabrowser.org/oma/group/F6QJJ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80UU9-1", "protein_name": "Membrane-associated progesterone receptor component 2", "gene_name": "Pgrmc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGDGDVKLSTLGSGGESGGDGSPGGAGATAARSSWVAALLATGGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQLRQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD", "length": 217 }, "evidence": [ { "id": "F6QJJ8", "url": "https://omabrowser.org/oma/group/F6QJJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" }, { "name": "smooth endoplasmic reticulum membrane", "id": "GO:0030868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030868", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adipose tissue development", "id": "GO:0060612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060612", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "F6QJJ8", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F6QJJ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 247, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F6QJJ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F6QJJ8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F6QJJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QJJ8" }, { "id": "SM01117", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01117" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cytochrome b5 heme-binding", "eco_id": "ECO_0000259", "start_pos": 127, "end_pos": 225, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Y2-1", "uniprot_ac": "F1N6Y2", "uniprot_id": "F1N6Y2_BOVIN", "mass": { "chemical_mass": 65319.0, "monoisotopic_mass": 65319.0 }, "refseq": { "ac": "NP_001179644", "name": "PHD finger protein 19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179644" }, "gene_names": [ { "name": "PHF19", "type": "recommended", "evidence": [ { "id": "F1N6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ] }, { "name": "PHF19", "type": "synonym", "evidence": [ { "id": "NP_001179644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179644" } ] } ], "protein_names": [ { "name": "PHD finger protein 19", "type": "recommended", "evidence": [ { "id": "F1N6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2/entry#names_and_taxonomy" } ] }, { "name": "PHD finger protein 19", "type": "synonym", "evidence": [ { "id": "NP_001179644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179644" } ] }, { "name": "Polycomb-like protein 3", "type": "synonym", "evidence": [ { "id": "F1N6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHF19", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2", "locus": { "chromosome": "8", "start_pos": 110242266, "end_pos": 110260673, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016958", "url": "https://www.ensembl.org/id/ENSBTAG00000016958" } ] } } ], "crossref": [ { "id": "F1N6Y2", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Y2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016958", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016958", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15579", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15579", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15581", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15581", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20451", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20451", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532056", "url": "https://www.ncbi.nlm.nih.gov/gene/532056", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532056", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532056", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HHMASIF", "url": "https://omabrowser.org/oma/group/HHMASIF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6Y2", "url": "https://www.orthodb.org/?gene=F1N6Y2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12628", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12628", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12628:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12628:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179644", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TV41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Y2-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENRALDPGTRDSYGATSHLPNKGALAKAKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADRPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLAPPEHGAASELRRRGKSKPSLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRRTVGSRKRKLAAKAYVPLRAKRRAAEPGGRCASDSSAEGASGPERPDEGVDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY", "length": 580, "header": "tr|F1N6Y2-1|F1N6Y2_BOVIN Isoform 1 of PHD finger protein 19 OS=Bos taurus OX=9913 GN=PHF19 PE=3 SV=2 CANONICAL=F1N6Y2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TV41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV41/entry", "sequence": { "sequence": "MHTHVLCFLYSLPQSCRHQTPSHRSTHALTRKNTRLSPCNLQCQWKLMENRALDPGTRDSYGATSHLPNKGALAKAKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADRPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLAPPEHGAASELRRRGKSKPSLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRRTVGSRKRKLAAKAYVPLRAKRRAAEPGGRCASDSSAEGASGPERPDEGVDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY", "length": 627, "header": "tr|A0AAA9TV41-1|F1N6Y2_BOVIN Computationally mapped isoform of PHD finger protein 19 OS=Bos taurus OX=9913 GN=PHF19 PE=3 SV=1 CANONICAL=F1N6Y2-1" }, "locus": { "chromosome": "8", "start_pos": 110260600, "end_pos": 110242838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102224.1" } ] } }, { "isoform_ac": "F1N6Y2-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2/entry", "sequence": { "sequence": "MENRALDPGTRDSYGATSHLPNKGALAKAKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADRPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLAPPEHGAASELRRRGKSKPSLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRRTVGSRKRKLAAKAYVPLRAKRRAAEPGGRCASDSSAEGASGPERPDEGVDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY", "length": 580, "header": "tr|F1N6Y2-1|F1N6Y2_BOVIN Isoform 1 of PHD finger protein 19 OS=Bos taurus OX=9913 GN=PHF19 PE=3 SV=2 CANONICAL=F1N6Y2-1" }, "locus": { "chromosome": "8", "start_pos": 110259185, "end_pos": 110242838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022557.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022557.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022557.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022557.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532056", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532056", "resource": "KEGG Pathway" }, { "id": "R-BTA-212300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212300", "resource": "Reactome", "description": "PRC2 methylates histones and DNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AKG3-1", "protein_name": "PHD finger protein 19", "gene_name": "PHF19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLVARLQVGPADTQPRVSVEADGESRCGPRDSGLLWCHQPPSQQRGLGQSQEQLQRPDVQADRGPVCAVPVDGWTVLSRKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADRPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTNTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLVPPENGASSEPRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRRTVGSRKRKLAAKAYMPLRAKRRAAELGGCCPSDSSAEGASGPERPDEGIDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY", "length": 602 }, "evidence": [ { "id": "F1N6Y2", "url": "https://omabrowser.org/oma/group/F1N6Y2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LBF8-1", "protein_name": "PHD finger protein 19", "gene_name": "Phf19", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METQALDPGTPEAYGPTSHLPNKGTLSKTKKNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKKVSSPKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCDICLGKTSGPMNEILICGKCGLGYHQQCHIPIAGSANRPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYQCRQWFHEACTQCLNEPMMFGDRFYLFLCSVCNQGPEYIERLPLRWVDIVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPTPPGKLLPDRGLMPSERGTSELLRKRGKNKPGLLPHEPQQQKRRVYRRKRAKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSTSSSQTVFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAAKAYVPLRAKRQAAELDGRCPSDSSAEGALGPEQPDEGIDRHTLESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLLEWEGTTPY", "length": 580 }, "evidence": [ { "id": "F1N6Y2", "url": "https://omabrowser.org/oma/group/F1N6Y2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M2BE79-1", "protein_name": "PHD finger protein 19 isoform X1", "gene_name": "phf19", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLESACRDGYLTAGSESLEPKHLHPNIEKSICDQETSLTVGQYVLCCWSDGLYYLGKIQRVSTSKQSCFVSFEDNSKFWVLWKDIQHAGIPGEEPKCSVCSDMSLDPGNEILICGKCGVGFHQLCHLPTVESSADPSPWFCRRCIFALAVRKGGALKKGQLAKDLQAMKQVLTYNPEELEWDSLHRTNHQQCYCYCGGPGQWYLKMLQCFRCEQWFHEACTQCLQDSMMFGDRFYLFICAVCNKGVEYIKRLALRWVDVVHLALYNLGVQSKKKYFELEEIVAFINNNWDRFQMGKLSNTPLPERGQLILDALNNYKSKFLCGKEIKKRKCIFRLRTRVPPNPPSKLYPEKAQKSDAHRGRKKAVSRSSNSDPAEKRRKKRAKWLLEDAIPNNDLTSSWSTNHHMANIFDFTLDELQSLKSTSSGQTFSLDQDSTDAASTSGSATTSVSYDFRKNVGSRKRKLPTSNYNLLATKRELVEREPSPINMPGEERNVLMENGIDSHTFESISEDDSSLLHLKSSITSYFGAAGRLTCGEKYQVLARRITPEGKVQYLVEWEGTTPY", "length": 563 }, "evidence": [ { "id": "F1N6Y2", "url": "https://omabrowser.org/oma/group/F1N6Y2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M1Y4-1", "protein_name": "PHD finger protein 19", "gene_name": "Phf19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METQALEPGTQEAFGATSPNKGAPSKTKKNFKDLMSKVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLLTHWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLALYNLGVQSKKRYFDFEEILAFVNHHWELLQLGKLTSTPVTERGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRVRVPPAPPGKLLPDRAQMPSDKGTFELLRKRGKSKPGLLPQESQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTDHHLASIFDFTLDEIQSLKSGSSGQTFFSDVDSTDAASTSGSASTSLSQDSRWTVGSRKRKLAAKAYRPLRAKHRAAEPDGRCASDSSAEGAPGPEQQDEGIDSHTFESISGDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLLEWEGTTPY", "length": 578 }, "evidence": [ { "id": "F1N6Y2", "url": "https://omabrowser.org/oma/group/F1N6Y2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T6S3-1", "protein_name": "PHD finger protein 19", "gene_name": "PHF19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENRALDPGTRDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADQPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLLPNENSASSELRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAAKAYMPLRAKRWAAELDGRCPSDSSAEGASVPERPDEGIDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY", "length": 580 }, "evidence": [ { "id": "F1N6Y2", "url": "https://omabrowser.org/oma/group/F1N6Y2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CXG9-1", "protein_name": "PHD finger protein 19", "gene_name": "Phf19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METQALEPGTLEAFGATSPNKGGLSKTKKNFKDLMSKVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLLTHWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLALYNLGVQSKKRYFDFEEILAFVNHHWELLQLGKLTSTPMTERGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPAPPGKLLPDRALMPSDKGTSELLRKKGKSKPGLLPQEPQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTDHHLASIFDFTLDEIQSLKSGSSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLTAKVHRPLRAKQRAAELEGRCASDSNAEGAVGPEQPDEGIDSHTLESISGDDSSLSHLKSSITNYFGAAGRLACGEKYRVLARRVTPEGKVQYLLEWEGTTPY", "length": 578 }, "evidence": [ { "id": "F1N6Y2", "url": "https://omabrowser.org/oma/group/F1N6Y2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "stem cell differentiation", "id": "GO:0048863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048863", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "stem cell population maintenance", "id": "GO:0019827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "histone H3K4me3 reader activity", "id": "GO:0140002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140002", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "histone H3K36me3 reader activity", "id": "GO:0140003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140003", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ESC/E(Z) complex", "id": "GO:0035098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035098", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N6Y2", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Y2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 580, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Y2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Y2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" }, { "id": "SM00333", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00333" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tudor", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 95, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y2" }, { "id": "SM00249", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00249" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Zinc finger PHD-type", "eco_id": "ECO_0000259", "start_pos": 98, "end_pos": 149, "start_aa": "Lys", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N388-1", "uniprot_ac": "F1N388", "uniprot_id": "F1N388_BOVIN", "mass": { "chemical_mass": 210492.0, "monoisotopic_mass": 210492.0 }, "refseq": {}, "gene_names": [ { "name": "AKAP11", "type": "recommended", "evidence": [ { "id": "F1N388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ] } ], "protein_names": [ { "name": "A-kinase anchoring protein 11", "type": "synonym", "evidence": [ { "id": "F1N388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N388/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKAP11", "url": "https://www.uniprot.org/uniprotkb/F1N388", "locus": { "chromosome": "12", "start_pos": 12461732, "end_pos": 12410376, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014752", "url": "https://www.ensembl.org/id/ENSBTAG00000014752" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533105", "url": "https://www.ncbi.nlm.nih.gov/gene/533105", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533105", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533105", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N388", "url": "https://www.orthodb.org/?gene=F1N388", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10226:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10226:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9TVH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N388-1", "url": "https://www.uniprot.org/uniprotkb/F1N388-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATFQSFRNNHMKTRASVRKSFNEDVFQSVKSLLQSEKELCSVSAEDCLKQDERANLTEVTFLGFNEETDAAHIQDLAAVSLELPDLLNSLHFCSLNENEIICMKDINKSSDINSDPLNQSQHPGMLCVMRVSPTLPRLKIDFIFSLLSKYATGIRYTVDTYLHHKHQLEATNEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGLNIIALRSQCDATSQTISGHHLDTHDFRVLVGSEQQKSLAKPSASLINILGHKKLPPVRTSVTTSVSEPWVQRSFYSSFAASEKGSDAQKPLFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETACPFLKDLAVGKPSQKKGHKHEKLCSVTTTMNPQKFKFDRPALPANVRKPTPRKPESPYSNLCDAPDSPRPVKASGEDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGEDRGHENPDSLYYTFEDYANSLSYEVLGSVLHSQHTNATSNTNNIKKGENKMVALQHGSLDQKSKSKNKPIMIDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALCQLAIKLTSSIFQMAFNELRRQCAFSLKERAISGLASFLVSEAFSDALQDLQYVKKQIFTNTVTRFAADLAEELVFEGIMEVCQFSYPLTPASLQGRSFHCEDRVVKSYARDLSESVIQEAFIELSQVDVTFTTKAAVSVSPENIKFVSTEDVVPATQTSVCSPTSNSQTVTVTKPVQEYKKEYTVQQALLCTSGIVTSIPVPLAGSALHPYRISSNTYQTKSHPSCDDSHLNGGPTPASVATKNKEEELACLRNICLPSDHNPGSQNEVKPTSDVVETKSSSKLTNDPVIIGDFSAAMVHTIVNETIDSVTSSKVAKTEEHTDCLTQTGKGKTPSFYWDQATVPQSEASKKDMFADRLSKSIIKHSIDESKSVIVNVDKNVLPKKDLPVPGDESQLTLEEFPKFLEAQDHLTHCSLSEVKDCVPEGKGSVAPGFSLETLPPCLAAAGQKADLKEIAKDKSVKKQNLHNSALEPLAFGQENSFPHSHAFSSTVLTCVDGLHVEDKQKMRDGNVIPDTPPSTPLVPSQAPSDWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVSSLSENEQNAIEKEEFMLKLMRSLSEEVESSDGEEQQEVDVKLEPAGKKVQFADALATHIVSLATEMAASHLNNKVIQEARVKSPCLNVQSQRSLSPAFFNCSDESLQALCSFAGDMAAEVITEAEKIAKVRSCMFFRRKRNSCVDGDQDHRSEEKLDVEAVAHPGGVDPFVLPLPPSSCLSGLTYKYPSCESVTDEYAGHIIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTAKVKCSSKIFPVQSSQVKTNDELLLFLNKEHQQEADTKRQSRSAGSYLHKNQTCEWTRDTCRNECSELRSFSTCLAHSITRDVKKELMASTGGLPKSLTDSCLYEKNVCDKDTETHVGPEFPKSLQPSSQNHRFSQSTGSLSGCGYGETVVQAIEQYANKVVGDTLELGLGSATFHVSEATKAVDRITYAEKLSPLVGQACRYCDRKELHDCTGNSSPRFPRPDSLAGSKPVSHSQLSSFYQKSRIFHLDVPQIHVDLDKKTVLAEKIVAEAIEKAERELSSTSQAADSGIGQEGVSFAESLSTEILASAVVSAGQAISSPKETEEIQSAESLGSQQMHLSIGEDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDNDEEEHQTDVEGLEQDGKTLLITNIDMEPCTVDPQLRIILQWLVASEAEVAELYFHDSTKKEFMQLTKRLQEKGWKVGDLLQAVLKYYEVVEKTSTVLDSEFPVQPLWPNRPVLGPWCV", "length": 1913, "header": "tr|F1N388-1|F1N388_BOVIN Isoform 1 of A-kinase anchoring protein 11 OS=Bos taurus OX=9913 GN=AKAP11 PE=4 SV=3 CANONICAL=F1N388-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TVH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH1/entry", "sequence": { "sequence": "MATFQSFRNNHMKTRASVRKSFNEDVFQSVKSLLQSEKELCSVSAEDCLKQDERANLTEVTFLGFNEETDAAHIQDLAAVSLELPDLLNSLHFCSLNENEIICMKDINKSSDINSDPLNQSQHPGMLCVMRVSPTLPRLKIDFIFSLLSKYATGIRYTVDTYLHHKHQLEATNEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGLNIIALRSQCDATSQTISGHHLDTHDFRVLVGSEQQKSLAKPSASLINILGHKKLPPVRTSVTTSVSEPWVQRSFYSSFAASEKGSDAQKPLFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETACPFLKDLAVGKPSQKKGHKHEKLCSVTTTMNPQKFKFDRPALPANVRKPTPRKPESPYSNLCDAPDSPRPVKASGEDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGEDRGHENPDSLYYTFEDYANSLSYEVLGSVLHSQHTNATSNTNNIKKGENKMVALQHGSLDQKSKSKNKPIMIDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALCQLAIKLTSSIFQMAFNELRRQCAFSLKERAISGLASFLVSEAFSDALQDLQYVKKQIFTNTVTRFAADLAEELVFEGIMEVCQFSYPLTPASLQGRSFHCEDRVVKSYARDLSESVIQEAFIELSQVDVTFTTKAAVSVSPENIKFVSTEDVVPATQTSVCSPTSNSQTVTVTKPVQEYKKEYTVQQALLCTSGIVTSIPVPLAGSALHPYRISSNTYQTKSHPSCDDSHLNGGPTPASVATKNKEEELACLRNICLPSDHNPGSQNEVKPTSDVVETKSSSKLTNDPVIIGDFSAAMVHTIVNETIDSVTSSKVAKTEEHTDCLTQTGKGKTPSFYWDQATVPQSEASKKDMFADRLSKSIIKHSIDESKSVIVNVDKNVLPKKDLPVPGDESQLTLEEFPKFLEAQDHLTHCSLSEVKDCVPEGKGSVAPGFSLETLPPCLAAAGQKADLKEIAKDKSVKKQNLHNSALEPLAFGQENSFPHSHAFSSTVLTCVDGLHVEDKQKMRDGNVIPDTPPSTPLVPSQAPSDWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVSSLSENEQNAIEKEEFMLKLMRSLSEEVESSDGEEQQEVDVKLEPAGKKVQFADALATHIVSLATEMAASHLNNKVIQEARVKSPCLNVQSQRSLSPAFFNCSDESLQALCSFAGDMAAEVITEAEKIAKVRSCMFFRRKRNSCVDGDQDHRSEEKLDVEAVAHPGGVDPFVLPLPPSSCLSGLTYKYPSCESVTDEYAGHIIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTAKVKCSSKIFPVQSSQVKTNDELLLFLNKEHQQEADTKRQSRSAGSYLHKNQTCEWTRDTCRNECSELRSFSTCLAHSITRDVKKELMASTGGLPKSLTDSCLYEKNVCDKDTETHVGPEFPKSLQPSSQNHRFSQSTGSLSGCGYGETVVQAIEQYANKVVGDTLELGLGSATFHVSEATKAVDRITYAEKLSPLVGQACRYCDRKELHDCTGNSSPRFPRPDSLAGSKPVSHSQLSSFYQKSRIFHLDVPQIHVDLDKKTVLAEKIVAEAIEKAERELSSTSQAADSGIGQEGVSFAESLSTEILASAVVSAGQAISSPKETEEIQSAESLGSQQMHLSIGEDSTGSWSNLSFEDEHQDESSSFHHLSESDGPDNDEEEHQTDVEGLEQDGKTLLITNIDMEPCTVDPQLRIILQWLVASEAEVAELYFHDSTKKEFMQLTKRLQEKGWKVGDLLQAVLKYYEVVEKTSSEERCKSLFDWLLENA", "length": 1877, "header": "tr|A0AAA9TVH1-1|F1N388_BOVIN Computationally mapped isoform of A-kinase anchoring protein 11 OS=Bos taurus OX=9913 GN=AKAP11 PE=4 SV=2 CANONICAL=F1N388-1" }, "locus": { "chromosome": "12", "start_pos": 12458740, "end_pos": 12422608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104647.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104647.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102617.2", "url": "https://www.ensembl.org/id/ENSBTAP00000102617.2" } ] } }, { "isoform_ac": "F1N388-1", "url": "https://www.uniprot.org/uniprotkb/F1N388/entry", "sequence": { "sequence": "MATFQSFRNNHMKTRASVRKSFNEDVFQSVKSLLQSEKELCSVSAEDCLKQDERANLTEVTFLGFNEETDAAHIQDLAAVSLELPDLLNSLHFCSLNENEIICMKDINKSSDINSDPLNQSQHPGMLCVMRVSPTLPRLKIDFIFSLLSKYATGIRYTVDTYLHHKHQLEATNEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGLNIIALRSQCDATSQTISGHHLDTHDFRVLVGSEQQKSLAKPSASLINILGHKKLPPVRTSVTTSVSEPWVQRSFYSSFAASEKGSDAQKPLFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETACPFLKDLAVGKPSQKKGHKHEKLCSVTTTMNPQKFKFDRPALPANVRKPTPRKPESPYSNLCDAPDSPRPVKASGEDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGEDRGHENPDSLYYTFEDYANSLSYEVLGSVLHSQHTNATSNTNNIKKGENKMVALQHGSLDQKSKSKNKPIMIDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALCQLAIKLTSSIFQMAFNELRRQCAFSLKERAISGLASFLVSEAFSDALQDLQYVKKQIFTNTVTRFAADLAEELVFEGIMEVCQFSYPLTPASLQGRSFHCEDRVVKSYARDLSESVIQEAFIELSQVDVTFTTKAAVSVSPENIKFVSTEDVVPATQTSVCSPTSNSQTVTVTKPVQEYKKEYTVQQALLCTSGIVTSIPVPLAGSALHPYRISSNTYQTKSHPSCDDSHLNGGPTPASVATKNKEEELACLRNICLPSDHNPGSQNEVKPTSDVVETKSSSKLTNDPVIIGDFSAAMVHTIVNETIDSVTSSKVAKTEEHTDCLTQTGKGKTPSFYWDQATVPQSEASKKDMFADRLSKSIIKHSIDESKSVIVNVDKNVLPKKDLPVPGDESQLTLEEFPKFLEAQDHLTHCSLSEVKDCVPEGKGSVAPGFSLETLPPCLAAAGQKADLKEIAKDKSVKKQNLHNSALEPLAFGQENSFPHSHAFSSTVLTCVDGLHVEDKQKMRDGNVIPDTPPSTPLVPSQAPSDWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVSSLSENEQNAIEKEEFMLKLMRSLSEEVESSDGEEQQEVDVKLEPAGKKVQFADALATHIVSLATEMAASHLNNKVIQEARVKSPCLNVQSQRSLSPAFFNCSDESLQALCSFAGDMAAEVITEAEKIAKVRSCMFFRRKRNSCVDGDQDHRSEEKLDVEAVAHPGGVDPFVLPLPPSSCLSGLTYKYPSCESVTDEYAGHIIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTAKVKCSSKIFPVQSSQVKTNDELLLFLNKEHQQEADTKRQSRSAGSYLHKNQTCEWTRDTCRNECSELRSFSTCLAHSITRDVKKELMASTGGLPKSLTDSCLYEKNVCDKDTETHVGPEFPKSLQPSSQNHRFSQSTGSLSGCGYGETVVQAIEQYANKVVGDTLELGLGSATFHVSEATKAVDRITYAEKLSPLVGQACRYCDRKELHDCTGNSSPRFPRPDSLAGSKPVSHSQLSSFYQKSRIFHLDVPQIHVDLDKKTVLAEKIVAEAIEKAERELSSTSQAADSGIGQEGVSFAESLSTEILASAVVSAGQAISSPKETEEIQSAESLGSQQMHLSIGEDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDNDEEEHQTDVEGLEQDGKTLLITNIDMEPCTVDPQLRIILQWLVASEAEVAELYFHDSTKKEFMQLTKRLQEKGWKVGDLLQAVLKYYEVVEKTSTVLDSEFPVQPLWPNRPVLGPWCV", "length": 1913, "header": "tr|F1N388-1|F1N388_BOVIN Isoform 1 of A-kinase anchoring protein 11 OS=Bos taurus OX=9913 GN=AKAP11 PE=4 SV=3 CANONICAL=F1N388-1" }, "locus": { "chromosome": "12", "start_pos": 12460728, "end_pos": 12422608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019629.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019629.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019629.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019629.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 825, "start_aa": "Thr", "end_pos": 825, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr825", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:533105", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533105", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase A regulatory subunit binding", "id": "GO:0034237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034237", "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "pmid": "" }, { "name": "protein kinase A binding", "id": "GO:0051018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051018", "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor protein serine/threonine kinase signaling pathway", "id": "GO:0007178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007178", "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "F1N388", "url": "https://www.uniprot.org/uniprotkb/F1N388" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1148, "end_pos": 1150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1252, "end_pos": 1254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1441, "end_pos": 1443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1605, "end_pos": 1607, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1742, "end_pos": 1744, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1765, "end_pos": 1767, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1782, "end_pos": 1784, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 519, "end_pos": 521, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 893, "end_pos": 895, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 825 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 1148, "end_pos": 1150 }, { "start_pos": 119, "end_pos": 121 }, { "start_pos": 1252, "end_pos": 1254 }, { "start_pos": 1441, "end_pos": 1443 }, { "start_pos": 1605, "end_pos": 1607 }, { "start_pos": 1742, "end_pos": 1744 }, { "start_pos": 1765, "end_pos": 1767 }, { "start_pos": 1782, "end_pos": 1784 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 519, "end_pos": 521 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 893, "end_pos": 895 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N6Q4-1", "uniprot_ac": "F1N6Q4", "uniprot_id": "F1N6Q4_BOVIN", "mass": { "chemical_mass": 33371.0, "monoisotopic_mass": 33371.0 }, "refseq": { "ac": "XP_005228028", "name": "uracil phosphoribosyltransferase homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228028" }, "gene_names": [ { "name": "UPRT", "type": "recommended", "evidence": [ { "id": "F1N6Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ] }, { "name": "UPRT", "type": "synonym", "evidence": [ { "id": "XP_005228028", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228028" } ] } ], "protein_names": [ { "name": "Uracil phosphoribosyltransferase homolog", "type": "recommended", "evidence": [ { "id": "F1N6Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4/entry#names_and_taxonomy" } ] }, { "name": "uracil phosphoribosyltransferase homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005228028", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228028" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UPRT", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4", "locus": { "chromosome": "X", "start_pos": 75911721, "end_pos": 75941848, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004549", "url": "https://www.ensembl.org/id/ENSBTAG00000004549" } ] } } ], "crossref": [ { "id": "F1N6Q4", "url": "https://alphafold.ebi.ac.uk/entry/F1N6Q4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004549", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004549", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540851", "url": "https://www.ncbi.nlm.nih.gov/gene/540851", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NLFCTPM", "url": "https://omabrowser.org/oma/group/NLFCTPM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6Q4", "url": "https://www.orthodb.org/?gene=F1N6Q4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF14681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228028", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228028", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9U1I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q4-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATELRCPDSMPCHNQQVNSASTQNPEPQQAGDLILAHAGGNSDSAATLTLLSGHAHSSVPAELDPQASGGATFNSENNGGTGNYDAPASDSLLGDCEISRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYEECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 306, "header": "tr|F1N6Q4-1|F1N6Q4_BOVIN Isoform 1 of Uracil phosphoribosyltransferase homolog OS=Bos taurus OX=9913 GN=UPRT PE=3 SV=1 CANONICAL=F1N6Q4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U1I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1I2/entry", "sequence": { "sequence": "MATELRCPDSMPCHNQQVNSASTQNPEPQQAGDLILAHAGGNSDSAATLTLLSGHAHSSVPAELDPQASGGATFNSENNGGTGNYDAPASDSLLGDCEISRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYEECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGSVSQSTMKRLQKNHLRESHLVGH", "length": 295, "header": "tr|A0AAA9U1I2-1|F1N6Q4_BOVIN Computationally mapped isoform of Uracil phosphoribosyltransferase homolog OS=Bos taurus OX=9913 GN=UPRT PE=3 SV=1 CANONICAL=F1N6Q4-1" }, "locus": { "chromosome": "X", "start_pos": 75941784, "end_pos": 75914068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103077.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103077.1" } ] } }, { "isoform_ac": "F1N6Q4-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4/entry", "sequence": { "sequence": "MATELRCPDSMPCHNQQVNSASTQNPEPQQAGDLILAHAGGNSDSAATLTLLSGHAHSSVPAELDPQASGGATFNSENNGGTGNYDAPASDSLLGDCEISRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYEECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 306, "header": "tr|F1N6Q4-1|F1N6Q4_BOVIN Isoform 1 of Uracil phosphoribosyltransferase homolog OS=Bos taurus OX=9913 GN=UPRT PE=3 SV=1 CANONICAL=F1N6Q4-1" }, "locus": { "chromosome": "X", "start_pos": 75941784, "end_pos": 75912814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005978.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005978.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005978.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005978.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G3Q5-1", "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "Uprt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATELQRPDSMPCHNRQVNSTSSPSPERLLAEDPVLDHAEENNAAMAKLTLLPGHAHSSVLSERDSPACCSTNLHCENHSDSSDSGNYEAPVGDSLLGDCELYPQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGHKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIHRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 309 }, "evidence": [ { "id": "F1N6Q4", "url": "https://omabrowser.org/oma/group/F1N6Q4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YKU7-1", "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "UPRT", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "AWRPRSARGEGAPAHGGDAVPQPAARRGRRPAAPGRADGAGGRLLPADPLRRALRGQQQRQPQPGQQQRQQRGGGGPQPRGGGLRVAARSAAEAAAHERSDPGAADHHQGQIRLVVEEGLNQLPYTECTVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 277 }, "evidence": [ { "id": "F1N6Q4", "url": "https://omabrowser.org/oma/group/F1N6Q4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B1AVZ0-1", "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "Uprt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASELQRPDSMPCHNRQVNSTSSPSPEHLLAEDRVLDHAEENNAAMAKLTLLPGHAHSSVLSERDSPACCSTNLHSENHSDSSDSGNYDAPVGGDSLLGDCELSRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGHKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIHRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 310 }, "evidence": [ { "id": "F1N6Q4", "url": "https://omabrowser.org/oma/group/F1N6Q4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1RPJ7-1", "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "UPRT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATELRCPDSMPCHNQQVNSASTPSLEPQQPGDLMPDHAGANSDSTAKQTLLSVHAHSIVTAERDPKACGSASFNSESNGGNYDASASDSLLGDCELFRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 304 }, "evidence": [ { "id": "F1N6Q4", "url": "https://omabrowser.org/oma/group/F1N6Q4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M9PHI7-1", "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "kri", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRTGSPSSSGSQSEEGSSSSDHQQPQQEAQEQEQQLHTPTHAHAAVPAATSEEILAEYGSNLKLLECNSQVAELLTILRDKNTTRSDFKFYADRLIRLVIEESLNQLPYTHCDVETPTGAIYEGLKYRSGNCGVSIIRSGEAMEQGLRDCCRSIRIGKILVESDANTHEARVVYARFPDDIGSRQVLLMYPIMSTGNTVLQAVNVLREHGVPESCIILSNLFCTPIAARTVVNAFPKLKILTSELHPVAPNHFGQKYFDCI", "length": 261 }, "evidence": [ { "id": "F1N6Q4", "url": "https://omabrowser.org/oma/group/F1N6Q4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q96BW1-1", "protein_name": "Uracil phosphoribosyltransferase homolog", "gene_name": "UPRT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATELQCPDSMPCHNQQVNSASTPSPEQLRPGDLILDHAGGNRASRAKVILLTGYAHSSLPAELDSGACGGSSLNSEGNSGSGDSSSYDAPAGNSFLEDCELSRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD", "length": 309 }, "evidence": [ { "id": "F1N6Q4", "url": "https://omabrowser.org/oma/group/F1N6Q4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "pmid": "" }, { "name": "ribosylnicotinamide kinase activity", "id": "GO:0050262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050262", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "pmid": "" }, { "name": "nicotinate riboside kinase activity", "id": "GO:0061769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061769", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N6Q4", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N6Q4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N6Q4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N6Q4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N6Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Q4" }, { "id": "PF14681", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14681" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphoribosyltransferase", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 291, "start_aa": "Asn", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1C2-1", "uniprot_ac": "F1N1C2", "uniprot_id": "F1N1C2_BOVIN", "mass": { "chemical_mass": 16011.0, "monoisotopic_mass": 16011.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Stathmin", "type": "recommended", "evidence": [ { "id": "F1N1C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1C2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1N1C2", "locus": {} } ], "crossref": [ { "id": "F1N1C2", "url": "https://alphafold.ebi.ac.uk/entry/F1N1C2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026505", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026505", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MACTDIK", "url": "https://omabrowser.org/oma/group/MACTDIK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10104", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10104", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10104:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10104:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00836", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00836", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSDIQVKKLEKPSSGQAFELTLSPQSKESVPEFPLSPPKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKGEPEKEVLQKAIEDNFSKMAEEKLTHKMEANKENREAQTATKLKDKHVEEVRKNKESKDPADETEAD", "length": 141, "header": "tr|F1N1C2-1|F1N1C2_BOVIN Isoform 1 of Stathmin OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=F1N1C2-1" }, "isoforms": [ { "isoform_ac": "F1N1C2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C2/entry", "sequence": { "sequence": "MASSDIQVKKLEKPSSGQAFELTLSPQSKESVPEFPLSPPKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKGEPEKEVLQKAIEDNFSKMAEEKLTHKMEANKENREAQTATKLKDKHVEEVRKNKESKDPADETEAD", "length": 141, "header": "tr|F1N1C2-1|F1N1C2_BOVIN Isoform 1 of Stathmin OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=F1N1C2-1" }, "locus": { "chromosome": "20", "start_pos": 21932083, "end_pos": 21931661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037688.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037688.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052803.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052803.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of microtubule polymerization or depolymerization", "id": "GO:0031110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031110", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" }, { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" }, { "name": "microtubule depolymerization", "id": "GO:0007019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007019", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "F1N1C2", "url": "https://www.uniprot.org/uniprotkb/F1N1C2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1C2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 141, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1C2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1C2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1F1-1", "uniprot_ac": "F1N1F1", "uniprot_id": "F1N1F1_BOVIN", "mass": { "chemical_mass": 134788.0, "monoisotopic_mass": 134788.0 }, "refseq": { "ac": "XP_002690857", "name": "codanin-1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690857" }, "gene_names": [ { "name": "CDAN1", "type": "recommended", "evidence": [ { "id": "F1N1F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F1" } ] }, { "name": "CDAN1", "type": "synonym", "evidence": [ { "id": "XP_002690857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690857" } ] } ], "protein_names": [ { "name": "Codanin 1", "type": "synonym", "evidence": [ { "id": "F1N1F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F1/entry#names_and_taxonomy" } ] }, { "name": "codanin-1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002690857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690857" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1F1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDAN1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1", "locus": { "chromosome": "10", "start_pos": 38019204, "end_pos": 38032459, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005751", "url": "https://www.ensembl.org/id/ENSBTAG00000005751" } ] } } ], "crossref": [ { "id": "F1N1F1", "url": "https://alphafold.ebi.ac.uk/entry/F1N1F1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005751", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005751", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538940", "url": "https://www.ncbi.nlm.nih.gov/gene/538940", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538940", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538940", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVVKDAQ", "url": "https://omabrowser.org/oma/group/CVVKDAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1F1", "url": "https://www.orthodb.org/?gene=F1N1F1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28678:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28678:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690857", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690857", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NSH8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSH8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1F1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1F1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVLESLLREELSVAAAVRWIARSAQSSEDDPREAAALSSLRPLRKEFVPFLLNFLREQSSRVLPQGPPTPAKAPGSSTGLPGRSGGPPRGGRGARNQLFPPIEASSATTADAPSARRGGRRRGPGPARERGRGPGGPEEGVSGECLPWAGGRRPRSSGSPSSPSLARSDPPNLSNLEEFPPVGSVPLGSAGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSVLDTSPWGHGLPSGCRSLQEEREMLRKERSKQLQQSPTPACPTLESGSPHPSRTGHLTAEPADPARVSSHHRLELVALVYSSCISENLVPNLFLELFFVLQLLTARRMVAAKDGDLETTPGAVDSLESPLFQSVHDCVFFAVKVLERQFHILSHLDKGTLKLLAENERLLCFSPALQGCLRAAYEGSVAKVSLAMPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDRHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLNMLGADKLGRLRRLQERLVAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIRELNSLALPQPEPSDEDGESDVDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPLTRELQDSILSLRSQVPPVLDVRALLQQGLRARRAVLTVPWLVEFLSLADHIVPMLDYYRSVFTLLLHLHRSLILSKESEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGQLDVLEVDTVASEHGLDSMPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFVRKITPTTTTGLGAQPPQTTQGLQAQLAQAFFHNHPPSLRRTVEFVAERIGSNCVKHIKATLVAELVRQAESLLQEQLVTQGQEGGDPAQLLEILCSQLCPHGAQALTQGREFCQKKSPGAVRALLPEETPAAVLSSAENIAVSLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPEEGVAPEYLEQLLGHLGQMLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQHQLERGQARRLLLMLLSLWKDDFQVPVPLQLLLRPRNVALLADTRPKEWDLLLFLLRELVEKDLMKRMEIKACLDSLYEAQWPGDFSEELATLFNLFSAEPHVPETQLRACELVQPNRGTVLAQS", "length": 1230, "header": "tr|F1N1F1-1|F1N1F1_BOVIN Isoform 1 of Codanin 1 OS=Bos taurus OX=9913 GN=CDAN1 PE=4 SV=2 CANONICAL=F1N1F1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NSH8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSH8/entry", "sequence": { "sequence": "MAAVLESLLREELSVAAAVRWIARSAQSSEDDPREAAALSSLRPLRKEFVPFLLNFLREQSSRVLPQGPPTPAKAPGSSTGLPGRSGGPPRGGRGARNQLFPPIEASSATTADAPSARRGGRRRGPGPARERGRGPGGPEEGVSGECLPWAGGRRPRSSGSPSSPSLARSDPPNLSNLEEFPPVGSVPLGSAGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSVLDTSPWGHGLPSGCRSLQEEREMLRKERSKQLQQSPTPACPTLESGSPHPSRTGHLTAEPADPARVSSHHRLELVALVYSSCISENLVPNLFLELFFVLQLLTARRMVAAKDGDLETTPGAVDSLESPLFQSVHDCVFFAVKVLERQFHILSHLDKGTLKLLAENERLLCFSPALQGCLRAAYEGSVAKVSLAMPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDRHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLNMLGADKLGRLRRLQERLVAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIRELNSLALPQPEPSDEDGESDVDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPLTRELQDSILSLRSQVPPVLDVRALLQQGLRARRAVLTVPWLVEFLSLADHIVPMLDYYRSVFTLLLHLHRSLILSKESEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGQLDVLEVDTVASEHGLDSMPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFVRKITPTTTTGLGAQPPQTTQGLQAQLAQAFFHNHPPSLRRTVEFVAERIGSNCVKHIKATLVAELVRQAESLLQEQLVTQGQEGGDPAQLLEILCSQLCPHGAQALTQGREFCQKKSPGAVRALLPEETPAAVLSSAENIAVSLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPEEGVAPEYLEQLLGHLGQMLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQHQLERGQARRLLLMLLSLWKDDFQVPVPLQLLLRPRNVALLADTRPKEWDLLLFLLRELVEKDLMKRMEIKACLDSLYEAQWPGVRSLHVLSGENRCHVPFILKEGQVIGPGILRIFQSSVNIVRCLEAHPEMKWLL", "length": 1242, "header": "tr|A0ABI0NSH8-1|A0ABI0NSH8_BOVIN Computationally mapped isoform of Codanin 1 OS=Bos taurus OX=9913 GN=CDAN1 PE=4 SV=1 CANONICAL=F1N1F1-1" }, "locus": { "chromosome": "10", "start_pos": 38032320, "end_pos": 38020934, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137434.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137434.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105938.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105938.1" } ] } }, { "isoform_ac": "F1N1F1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1/entry", "sequence": { "sequence": "MAAVLESLLREELSVAAAVRWIARSAQSSEDDPREAAALSSLRPLRKEFVPFLLNFLREQSSRVLPQGPPTPAKAPGSSTGLPGRSGGPPRGGRGARNQLFPPIEASSATTADAPSARRGGRRRGPGPARERGRGPGGPEEGVSGECLPWAGGRRPRSSGSPSSPSLARSDPPNLSNLEEFPPVGSVPLGSAGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSVLDTSPWGHGLPSGCRSLQEEREMLRKERSKQLQQSPTPACPTLESGSPHPSRTGHLTAEPADPARVSSHHRLELVALVYSSCISENLVPNLFLELFFVLQLLTARRMVAAKDGDLETTPGAVDSLESPLFQSVHDCVFFAVKVLERQFHILSHLDKGTLKLLAENERLLCFSPALQGCLRAAYEGSVAKVSLAMPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDRHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLNMLGADKLGRLRRLQERLVAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIRELNSLALPQPEPSDEDGESDVDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPLTRELQDSILSLRSQVPPVLDVRALLQQGLRARRAVLTVPWLVEFLSLADHIVPMLDYYRSVFTLLLHLHRSLILSKESEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGQLDVLEVDTVASEHGLDSMPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFVRKITPTTTTGLGAQPPQTTQGLQAQLAQAFFHNHPPSLRRTVEFVAERIGSNCVKHIKATLVAELVRQAESLLQEQLVTQGQEGGDPAQLLEILCSQLCPHGAQALTQGREFCQKKSPGAVRALLPEETPAAVLSSAENIAVSLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPEEGVAPEYLEQLLGHLGQMLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQHQLERGQARRLLLMLLSLWKDDFQVPVPLQLLLRPRNVALLADTRPKEWDLLLFLLRELVEKDLMKRMEIKACLDSLYEAQWPGDFSEELATLFNLFSAEPHVPETQLRACELVQPNRGTVLAQS", "length": 1230, "header": "tr|F1N1F1-1|F1N1F1_BOVIN Isoform 1 of Codanin 1 OS=Bos taurus OX=9913 GN=CDAN1 PE=4 SV=2 CANONICAL=F1N1F1-1" }, "locus": { "chromosome": "10", "start_pos": 38032320, "end_pos": 38020208, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007561.8", "url": "https://www.ensembl.org/id/ENSBTAT00000007561.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007561.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007561.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 203, "start_aa": "Thr", "end_pos": 203, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr203", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 270, "start_aa": "Thr", "end_pos": 270, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr270", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 71, "start_aa": "Thr", "end_pos": 71, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr71", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538940", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538940", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LK58-1", "protein_name": "Codanin 1", "gene_name": "Cdan1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCFPRGMLLQSLLPACPGCRPAPRALLCQPLPGRPPCGLSRWRPALSADPLAPRPLLLPQDSSEVAALSALRPLRKEFVPFLLNFLREQSSRVLPQGPSTPAKTPGASAALPARQGAPPRGGRGARSQLFPATEPLSTSAEAPLARRAGRRRGPGPSRERGGRGSGGPEEGASSESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSAGRTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKARSKQLQQSPTPACPAPDSGSPVPNRTGNLTAEPADPARVSSRQRLELVALIYSSCIAENLVPNLFLELFFVLQLLTARRMAATKDSDLESSQGALDSLETPLFRSIHDCVFFAVQVLEHQFQVLSYLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKVSLVIPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPSWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGSVLGEAPDVLNMLGADKLGRLRQLQERLIAPQSSGGPCPPPTFPGCQGFFRDFIMSASSFHFNQHLMDSLSLKIRELNGLRLPQHEPGDEDGESDVDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYRGHEPPPTRELQDSILALRSQVPPVLDIRALLQQGLWARRAVLTVPWLVEFLSFADHIVPLLDYYRSVFTLLLHLHRSLVLSKENEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEDGQVDAFEVDTTTSEHGLDSVPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFVRKITPTTTTSLGTLPLKTSQGLQAQLAEAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQEQLVTRGQEGGDPAQLLEFLCSQLCPHGAQALTQGREFCQKKSPTALRALLPEETPAAVLSSAENIAVGLATEKACSWLSANITALIRREVKAAVSRMLRAQGPEPTARVERRGCSRACEHHAPLPSHLISEIKDVLSLAAGPRDPEEGVSPEHLEQLLNQLGQSLKCRQFLCPTAEQHLAKCSVELASLLVADQIPILGPPTQHRLDRGHARRLLHMLLSLWKDDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKDLMGHLEIEACLVSLNEAQWPGDFSEELSTLFRLFLAEPHLLEPQLRACELMQPNRGTVLAQS", "length": 1260 }, "evidence": [ { "id": "F1N1F1", "url": "https://omabrowser.org/oma/group/F1N1F1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CC12-1", "protein_name": "Codanin-1", "gene_name": "Cdan1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVLESLLREEVPVAAAVRWIARSTPSSEDSSEVAALSALRPLRKEFVPFLLNFLREQSSRVLPQGPSTPAKTPVASAALPARQGAPARGGRGARSQLFPAAEPLSAAAEAPLARRAGRRRGPGPGPSRERGGRGSGAAEEGASGESPPWAGGRKPKGSGSPGSPRLSLSDPPNLSNLEEFPPVGTVPPGSAGRTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSTLDTSPWGLGLPPGCRSLQEEREMLRKARTKQLQQSPTPASPIPESGSPVPSRTGNLTAEPADPARVSSRQRLELVALIYSSCIAENLVPNLFLELFFVLQLLTARRMVATKDSDLESSQGALDSLDTPLFRSIHDCVFFAVQVLEHQFQVLSYLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKVSLVIPPSAQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPSWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGSVLGEAPDVLNMLGADKLGRLRQLQERLIAPQSSGGPCPPPTFPGCQGFFRDFIMSASSFHFNQHLMDSLSLKIRELNGLRLPQHEPGDEDGESDMDWQGERRQFAVVLLSLRLLAKFLGFVAFLPYRGHEPPPTRELQDSILALRSQVPPVLDIRALLQQGLWARRAVLTVPWLVEFLSFADHIVPLLDYYRSVFTLLLRLHRSLVLSKENEGEMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEDGQVDAFEVTTTASEHGLDSVPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFVRKITPTTTSSLGALPLQTSQGLQAQLAEAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVHQAESLLQEQLVARGQEGGDPAQLLESLCSQLCPHGAQALTQGREFCQRKSPTAVRALLPEETPAAVLSSAENIAVGLATEKACSWLSANITALIRREVKAAVSRMLRAQGPEPTARVERRGCSRACEHHAPLPSHLISEIKFHHCSLQDVLSLAAGPRDPEEGVSPEHLEQLLNQMGQSLRCRQFLCPTAEQHLAKCSVELASLLVADQIPILGPPTQHRLERGHARRLLHMLLSLWKDDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKDLMGHLEIEACLGRLNEAQWPGDFSEELSTLFRLFLAEPHLLEPQLRACELMQPNRGTVLAQS", "length": 1239 }, "evidence": [ { "id": "F1N1F1", "url": "https://omabrowser.org/oma/group/F1N1F1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IWY9-2", "protein_name": "Codanin-1", "gene_name": "CDAN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRALRKEFVPFLLNFLREQSSRVLPQGPPTPAKTPGASAALPGRPGGPPRGSRGARSQLFPPTEAQSTAAEAPLARRGGRRRGPGPARERGGRGLEEGVSGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPPVGSVPPGPTGTKPSRRINPTPVSEERSLSKPKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSPLPSRTGSLTDEPADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDPELSPAVLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKVSLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCPPPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGESDVDWQGERKQFAVVLLSLRLLAKFLGFVAFLPYRGPEPPPTGELQDSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAPEHGLDNAPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPSQTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGDPAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEKACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSLWKEDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFLAEPHLPEPQLRACELVQPNRGTVLAQS", "length": 1227 }, "evidence": [ { "id": "F1N1F1", "url": "https://omabrowser.org/oma/group/F1N1F1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8T626-1", "protein_name": "Protein disks lost", "gene_name": "dlt", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF", "length": 1240 }, "evidence": [ { "id": "F1N1F1", "url": "https://omabrowser.org/oma/group/F1N1F1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1F1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "F1N1F1", "url": "https://www.uniprot.org/uniprotkb/F1N1F1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 445, "end_pos": 447, "annotation": "n_glycosylation_sequon" }, { "start_pos": 983, "end_pos": 985, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1F1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1F1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1F1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1F1" }, { "id": "PF15296", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15296" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Codanin-1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 788, "end_pos": 902, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 71, 203, 270 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 174, "end_pos": 176 }, { "start_pos": 445, "end_pos": 447 }, { "start_pos": 983, "end_pos": 985 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1H5-1", "uniprot_ac": "F1N1H5", "uniprot_id": "F1N1H5_BOVIN", "mass": { "chemical_mass": 97293.0, "monoisotopic_mass": 97293.0 }, "refseq": { "ac": "XP_005214364", "name": "protein MCM10 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214364" }, "gene_names": [ { "name": "MCM10", "type": "recommended", "evidence": [ { "id": "F1N1H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ] }, { "name": "MCM10", "type": "synonym", "evidence": [ { "id": "XP_005214364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214364" } ] } ], "protein_names": [ { "name": "Protein MCM10 homolog", "type": "recommended", "evidence": [ { "id": "F1N1H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1H5/entry#names_and_taxonomy" } ] }, { "name": "protein MCM10 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214364" } ] } ], "function": [ { "annotation": "Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38.", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5#function" }, { "database": "UniProtKB", "id": "ARBA00060252", "url": "https://www.uniprot.org/uniprotkb/ARBA00060252#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCM10", "url": "https://www.uniprot.org/uniprotkb/F1N1H5", "locus": { "chromosome": "13", "start_pos": 27884154, "end_pos": 27854597, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016406", "url": "https://www.ensembl.org/id/ENSBTAG00000016406" } ] } } ], "crossref": [ { "id": "F1N1H5", "url": "https://alphafold.ebi.ac.uk/entry/F1N1H5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016406", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016406", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527595", "url": "https://www.ncbi.nlm.nih.gov/gene/527595", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015411", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015411", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1H5", "url": "https://www.orthodb.org/?gene=F1N1H5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13454:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13454:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09329", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09329", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09332", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09332", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22379", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22379", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24863", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24863", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214364", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214364", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1H5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1H5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGEEDDLSLLTALLEENESALGCNSEESQPLTQEDGEPDSYDELFDADGDGESYTEETDEGEVEKAENQKENLATLFGDMGDLTDEEEAPTSQSTKERVVPAPGPSQGKTNQELQDELRKLQEQMKSLQEQLKLATIKQPASPALSRKTPVDKSPRPPLKEKKIQESLCFSAELDVPTLPKPKRVARTPKVSPAEPQCSPLKMTSVPSQPLRTTPGNKPGGVTRDQSAGTPRSSGEMAQEVSVEAFSGLRLRKPRVSSTEMNKKMIGRKLIRLSQLKEKMASEKLEEIDWVTFGVILKKITPQSSNSGKTFSIWRLNDLRDLTRCVSLFLFGEVHKELWKTEQGSVIGLLNANPMKPKDGSEEMCLSIDHPQKILIMGEALDLGTCKAKKKNGEPCTQIVNLNDCEYCQYHIQAQYKRLSARRADLQSTFSGGRIPKKFACKGISLRERLCQDGFYYGGISSASYAASIAAAVAPKKKIQTTLSNLVVKGTDLILQETQQKLGIPQKSLSCSEEFRELMDLPTSGARNLKHHLAKAKSSGIVGSLKPAFQSISASALLKQQKQHMLEMRKKKSEEIQKRFLQSSSEIKSPAVPSSSQQPPCRSPPMGAEFPKMKGTPTTQMPKLGRGISEGDDVLFFDESPPPRPKLNALAEAKKLAAITKLRSKGRILTKTDPNSIKKLKEPQDVLEVKERVEKNSTFSPQAEDELEPAKKKRREQLAYLESEEFQTILKAKSRHTGILKEAEAELQERYFEPLVKKEQMEEKMRNTREVKCRVVTCKTCAYTHFKPLETCVSEQHDYHWHDGVKRFFKCACGNRTISLDRLPQKHCSNCGLFKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK", "length": 871, "header": "tr|F1N1H5-1|F1N1H5_BOVIN Isoform 1 of Protein MCM10 homolog OS=Bos taurus OX=9913 GN=MCM10 PE=3 SV=4 CANONICAL=F1N1H5-1" }, "isoforms": [ { "isoform_ac": "F1N1H5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1H5/entry", "sequence": { "sequence": "MDGEEDDLSLLTALLEENESALGCNSEESQPLTQEDGEPDSYDELFDADGDGESYTEETDEGEVEKAENQKENLATLFGDMGDLTDEEEAPTSQSTKERVVPAPGPSQGKTNQELQDELRKLQEQMKSLQEQLKLATIKQPASPALSRKTPVDKSPRPPLKEKKIQESLCFSAELDVPTLPKPKRVARTPKVSPAEPQCSPLKMTSVPSQPLRTTPGNKPGGVTRDQSAGTPRSSGEMAQEVSVEAFSGLRLRKPRVSSTEMNKKMIGRKLIRLSQLKEKMASEKLEEIDWVTFGVILKKITPQSSNSGKTFSIWRLNDLRDLTRCVSLFLFGEVHKELWKTEQGSVIGLLNANPMKPKDGSEEMCLSIDHPQKILIMGEALDLGTCKAKKKNGEPCTQIVNLNDCEYCQYHIQAQYKRLSARRADLQSTFSGGRIPKKFACKGISLRERLCQDGFYYGGISSASYAASIAAAVAPKKKIQTTLSNLVVKGTDLILQETQQKLGIPQKSLSCSEEFRELMDLPTSGARNLKHHLAKAKSSGIVGSLKPAFQSISASALLKQQKQHMLEMRKKKSEEIQKRFLQSSSEIKSPAVPSSSQQPPCRSPPMGAEFPKMKGTPTTQMPKLGRGISEGDDVLFFDESPPPRPKLNALAEAKKLAAITKLRSKGRILTKTDPNSIKKLKEPQDVLEVKERVEKNSTFSPQAEDELEPAKKKRREQLAYLESEEFQTILKAKSRHTGILKEAEAELQERYFEPLVKKEQMEEKMRNTREVKCRVVTCKTCAYTHFKPLETCVSEQHDYHWHDGVKRFFKCACGNRTISLDRLPQKHCSNCGLFKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK", "length": 871, "header": "tr|F1N1H5-1|F1N1H5_BOVIN Isoform 1 of Protein MCM10 homolog OS=Bos taurus OX=9913 GN=MCM10 PE=3 SV=4 CANONICAL=F1N1H5-1" }, "locus": { "chromosome": "13", "start_pos": 27884135, "end_pos": 27857053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021822.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021822.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021822.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021822.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" }, { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "F1N1H5", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 816, "end_pos": 818, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1H5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 871, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1H5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1H5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1H5" }, { "id": "SM01280", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01280" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Replication factor Mcm10 C-terminal", "eco_id": "ECO_0000259", "start_pos": 520, "end_pos": 869, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 697, "end_pos": 699 }, { "start_pos": 816, "end_pos": 818 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1H6-1", "uniprot_ac": "F1N1H6", "uniprot_id": "F1N1H6_BOVIN", "mass": { "chemical_mass": 34470.0, "monoisotopic_mass": 34470.0 }, "refseq": { "ac": "NP_001377051", "name": "olfactory receptor family 10 subfamily J member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377051" }, "gene_names": [ { "name": "OR10J1", "type": "recommended", "evidence": [ { "id": "F1N1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ] }, { "name": "OR10J1", "type": "synonym", "evidence": [ { "id": "NP_001377051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377051" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 10 subfamily J member 1", "type": "synonym", "evidence": [ { "id": "F1N1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1H6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 10 subfamily J member 1", "type": "synonym", "evidence": [ { "id": "NP_001377051", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377051" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377051" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10J1", "url": "https://www.uniprot.org/uniprotkb/F1N1H6", "locus": { "chromosome": "3", "start_pos": 10270004, "end_pos": 10270966, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054704", "url": "https://www.ensembl.org/id/ENSBTAG00000054704" } ] } } ], "crossref": [ { "id": "F1N1H6", "url": "https://alphafold.ebi.ac.uk/entry/F1N1H6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054539", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054539", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530601", "url": "https://www.ncbi.nlm.nih.gov/gene/530601", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530601", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530601", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N1H6", "url": "https://www.orthodb.org/?gene=F1N1H6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377051", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKKNHTLVNEFTLQGFSSFCEHQFTLFIVFFALYMLTLAGNIITVAIISLDRRLHTPMYFFLGMLSASETVYTVIIIPKMLCNLVGLSQSISLAGCAAQMFFFITLAINNCFLLTAMGYDRYVAICHPLRYTVIMNRRVCIQLVWGACSIGLIVAMTQVTSVFRLPFCATKVAHFFCDIWPVMKLSCIDTTVNEILTLIISVLVILVPMGLVFISYILIISTILKIASAEGRKKAFATCASHLTVVIVHYGCASIAYLKPKSENSKDEDQLISVTYTVVTPLLNPVVYTLRNKEAKDALLRAIGRKLS", "length": 309, "header": "tr|F1N1H6-1|F1N1H6_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily J member 1 OS=Bos taurus OX=9913 GN=OR10J1 PE=3 SV=4 CANONICAL=F1N1H6-1" }, "isoforms": [ { "isoform_ac": "F1N1H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1H6/entry", "sequence": { "sequence": "MKKKNHTLVNEFTLQGFSSFCEHQFTLFIVFFALYMLTLAGNIITVAIISLDRRLHTPMYFFLGMLSASETVYTVIIIPKMLCNLVGLSQSISLAGCAAQMFFFITLAINNCFLLTAMGYDRYVAICHPLRYTVIMNRRVCIQLVWGACSIGLIVAMTQVTSVFRLPFCATKVAHFFCDIWPVMKLSCIDTTVNEILTLIISVLVILVPMGLVFISYILIISTILKIASAEGRKKAFATCASHLTVVIVHYGCASIAYLKPKSENSKDEDQLISVTYTVVTPLLNPVVYTLRNKEAKDALLRAIGRKLS", "length": 309, "header": "tr|F1N1H6-1|F1N1H6_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily J member 1 OS=Bos taurus OX=9913 GN=OR10J1 PE=3 SV=4 CANONICAL=F1N1H6-1" }, "locus": { "chromosome": "3", "start_pos": 10344152, "end_pos": 10343226, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054562.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054562.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052800.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052800.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530601", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530601", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N1H6", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1H6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1H6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1H6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1H6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1I1-1", "uniprot_ac": "F1N1I1", "uniprot_id": "F1N1I1_BOVIN", "mass": { "chemical_mass": 71169.0, "monoisotopic_mass": 71169.0 }, "refseq": { "ac": "XP_002686308", "name": "guanylate-binding protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686308" }, "gene_names": [ { "name": "LOC513659", "type": "recommended", "evidence": [ { "id": "F1N1I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ] }, { "name": "LOC513659", "type": "synonym", "evidence": [ { "id": "XP_002686308", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686308" } ] } ], "protein_names": [ { "name": "Guanylate binding protein family member 6", "type": "synonym", "evidence": [ { "id": "F1N1I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1I1/entry#names_and_taxonomy" } ] }, { "name": "guanylate-binding protein 6", "type": "synonym", "evidence": [ { "id": "XP_002686308", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686308" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC513659", "url": "https://www.uniprot.org/uniprotkb/F1N1I1", "locus": {} } ], "crossref": [ { "id": "F1N1I1", "url": "https://alphafold.ebi.ac.uk/entry/F1N1I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038625", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038625", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01851", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01851", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513659", "url": "https://www.ncbi.nlm.nih.gov/gene/513659", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036543", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513659", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513659", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IMMLEHT", "url": "https://omabrowser.org/oma/group/IMMLEHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1I1", "url": "https://www.orthodb.org/?gene=F1N1I1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10751", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02263", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002686308", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686308", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1I1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSGPNMMNPICLVENDNEILSVNQKALQILEKISQPVVVVGIVGLYRTGKSYLMNRLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKENHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSTSTINHQALEQLYYVTELTELIQAKSSPRPDGVEDSTEFVSFFPDFIWAVRDFTLELKLNGHPITEDQYLENALKLIPGRNPKAKTSNLPRECIRHFFPTRKCFVFDWPTNDKELLHNIENVSEDQLDPKFLKQTNNFCSYIFTNAKIKTLKEGIMVTGNRLRTLVVTYVDTINTGAVPCLENAVTTLAQLENSAAVQKAADHYSEQMTQRLSLPTETFQELLEVHAACEREAIAIFMESSFKDKDQEFQMGLLEVIKNKKEGFMLQNEEASIKYCQAKLDELSKALMQSISAGAFSVPGGHKLYRKAMERLQQDYCQVPRKGVKENEVLQSFLQSQVVVEKSILQADKALTDGEKAVAEERARNETAEKELELLRQKLQEQEQEMEAQQRSLQENIAQLTEKLERERENILREQTMMLEHKLKAQEALLKEGFRQKSENMSAEINHLRNMIDNTNDGNASWIALVLDRFGKEIASVLCAPGKLLGHIVRGMGSLFKK", "length": 628, "header": "tr|F1N1I1-1|F1N1I1_BOVIN Isoform 1 of Guanylate binding protein family member 6 OS=Bos taurus OX=9913 GN=LOC513659 PE=3 SV=3 CANONICAL=F1N1I1-1" }, "isoforms": [ { "isoform_ac": "F1N1I1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1/entry", "sequence": { "sequence": "MTSGPNMMNPICLVENDNEILSVNQKALQILEKISQPVVVVGIVGLYRTGKSYLMNRLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKENHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSTSTINHQALEQLYYVTELTELIQAKSSPRPDGVEDSTEFVSFFPDFIWAVRDFTLELKLNGHPITEDQYLENALKLIPGRNPKAKTSNLPRECIRHFFPTRKCFVFDWPTNDKELLHNIENVSEDQLDPKFLKQTNNFCSYIFTNAKIKTLKEGIMVTGNRLRTLVVTYVDTINTGAVPCLENAVTTLAQLENSAAVQKAADHYSEQMTQRLSLPTETFQELLEVHAACEREAIAIFMESSFKDKDQEFQMGLLEVIKNKKEGFMLQNEEASIKYCQAKLDELSKALMQSISAGAFSVPGGHKLYRKAMERLQQDYCQVPRKGVKENEVLQSFLQSQVVVEKSILQADKALTDGEKAVAEERARNETAEKELELLRQKLQEQEQEMEAQQRSLQENIAQLTEKLERERENILREQTMMLEHKLKAQEALLKEGFRQKSENMSAEINHLRNMIDNTNDGNASWIALVLDRFGKEIASVLCAPGKLLGHIVRGMGSLFKK", "length": 628, "header": "tr|F1N1I1-1|F1N1I1_BOVIN Isoform 1 of Guanylate binding protein family member 6 OS=Bos taurus OX=9913 GN=LOC513659 PE=3 SV=3 CANONICAL=F1N1I1-1" }, "locus": { "chromosome": "3", "start_pos": 53888001, "end_pos": 53866979, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054825.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054825.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052801.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052801.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513659", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513659", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZV82-1", "protein_name": "Guanylate binding protein 7", "gene_name": "Gbp7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASASSMEAPICLVENENEELRVNPKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPCKPKFTLVLLDTEGLGDVEKCDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRTKSTPRSEEIDDSDEFVGFFPDFIWVVRDFVLELKLDGRVITADEYLENALKLIPGRSLKAQNSNLPRECIRHFFPRRKCFVFDRPIKEKELLVHVEEMPEDELDHNFREQSNVFCSYIFSNAKAKTLKEGIMVNGNRLATLVTTYVDAINSGAVPCLENAVTTLAQRENSAAVQKAAEHYSEQMAQRLRLPTDTLQELLDVHSACEKEAIAVFMEHSFKDENQEFQKNLVVTIVEKREDFSRQNEAASLSHCQAELDKLSESLRESISCGAFSVPGGHSLYLEARKKVEQDYEQVPRKGVKANHVLQSFLQSQIVIENSILQSDKALTVNQKAMEVERAQKEAAEKEQELLRQKQKELQQVMESQERSYKENIVQLHEKMETERKNILEKQEEMLAHKLKVQEEMLNEGFKRKYEAMDSEISQLQKQIQQNKEQNSSLAAQIFDGFGNVLMSVLPGTGKLFGLGLKILSRKMK", "length": 627 }, "evidence": [ { "id": "F1N1I1", "url": "https://omabrowser.org/oma/group/F1N1I1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZN66-1", "protein_name": "Guanylate-binding protein 6", "gene_name": "GBP6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF", "length": 633 }, "evidence": [ { "id": "F1N1I1", "url": "https://omabrowser.org/oma/group/F1N1I1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91Z40-1", "protein_name": "Guanylate-binding protein 7", "gene_name": "Gbp7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGPNMEAPVCLVENENEELRVNSKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPSKPKFTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTERIRAKSTSRSEEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLENALKLIPGMSIKAQKANLPRECIRHFFPRRKCFVFDRPTKDKELLVHVEEMPEDQLDHSFQVQSKEFCSYIFSNSKAKTLKEGIVVNGNRLATLVTTYVDAINSGDVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHTACEKEAIAVFMEHSFKDENQQFQKNLVVTIEEKKEDFLRQNEAASLSHCQAELDKLSESLRESISRGVFSVPGGHRLYLEARKKVEQDYERVPRKGVKANHVLQSFLQSQISIEDSIMQSDKALTDGQKAMEAERAQKEAAEKEQELLRQKQKELQQVMEAQERSYKENVAQLHEKMETERKNILREQEVKLEHKLKIQKDMLNEGFKRKCEAMDLEISQLQKEIQLNKEKNSSLGAKILDGFGDVLISVVPGSGKYFGLGLKILSSQMNQTQNSDKVRKL", "length": 638 }, "evidence": [ { "id": "F1N1I1", "url": "https://omabrowser.org/oma/group/F1N1I1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "pmid": "" }, { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "pmid": "" }, { "name": "defense response to protozoan", "id": "GO:0042832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "F1N1I1", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 570, "end_pos": 572, "annotation": "n_glycosylation_sequon" }, { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1I1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 628, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1I1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1I1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1I1" }, { "id": "PS51715", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51715" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GB1/RHD3-type G", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 277, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 570, "end_pos": 572 }, { "start_pos": 589, "end_pos": 591 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1K9-1", "uniprot_ac": "F1N1K9", "uniprot_id": "F1N1K9_BOVIN", "mass": { "chemical_mass": 95981.0, "monoisotopic_mass": 95981.0 }, "refseq": { "ac": "XP_005215465", "name": "trimethylguanosine synthase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215465" }, "gene_names": [ { "name": "TGS1", "type": "recommended", "evidence": [ { "id": "F1N1K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ] }, { "name": "TGS1", "type": "synonym", "evidence": [ { "id": "XP_005215465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215465" } ] } ], "protein_names": [ { "name": "Trimethylguanosine synthase", "type": "recommended", "evidence": [ { "id": "F1N1K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K9/entry#names_and_taxonomy" } ] }, { "name": "Cap-specific guanine-N(2) methyltransferase", "type": "synonym", "evidence": [ { "id": "F1N1K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K9/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor coactivator 6-interacting protein", "type": "synonym", "evidence": [ { "id": "F1N1K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K9/entry#names_and_taxonomy" } ] }, { "name": "PRIP-interacting protein with methyltransferase motif", "type": "synonym", "evidence": [ { "id": "F1N1K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1K9/entry#names_and_taxonomy" } ] }, { "name": "trimethylguanosine synthase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005215465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215465" } ] } ], "function": [ { "annotation": "Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9#function" }, { "database": "UniProtKB", "id": "ARBA00057179", "url": "https://www.uniprot.org/uniprotkb/ARBA00057179#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TGS1", "url": "https://www.uniprot.org/uniprotkb/F1N1K9", "locus": { "chromosome": "14", "start_pos": 23095949, "end_pos": 23070145, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005898", "url": "https://www.ensembl.org/id/ENSBTAG00000005898" } ] } } ], "crossref": [ { "id": "F1N1K9", "url": "https://alphafold.ebi.ac.uk/entry/F1N1K9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005898", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511392", "url": "https://www.ncbi.nlm.nih.gov/gene/511392", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1K9", "url": "https://www.orthodb.org/?gene=F1N1K9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14741", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14741", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14741:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14741:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-191859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-400206", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-400206", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9707564", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005215465", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215465", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "78471", "url": "https://www.rhea-db.org/rhea/78471", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "78475", "url": "https://www.rhea-db.org/rhea/78475", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "78479", "url": "https://www.rhea-db.org/rhea/78479", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "78507", "url": "https://www.rhea-db.org/rhea/78507", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1K9-1", "url": "https://www.uniprot.org/uniprotkb/F1N1K9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYCKKWRPVAEMCLFLEDLREGSRILCLCSRAFVEDRKLYNLGLKGYYVKDDDNSAGEQATEEEEGGHSQGPAEPHDNRCPDPDESELDSEAELMRSMGLPLQFGRMSAHKNFEESMNTRNKVKIMKKKKKKHQKKYLDEIKRESWRQCEEDDVSASDDPSSSENENTRKYKLQSQKGTEAESFPVENTVGPKLEITEMWEKYWNEYGGGLLWQSWQEKHADQTLCPEPWNVPDTKEEWEQHYSQMYWYYLEQFQYWEAQGWTFDASQSQDTDPGGSEIEVDNKKDENHMKADELFSPSLSVGSESSSSSDKDHSEILNGISNLSLNSEKVEQRQLDPSLSCDGRQCLSEVPSRRECPASGHSEPSHGGNTESSLSGSRSTDQPAQDSQESSEANTVRDGRHRSGTDGDESGDDPPEEKRSKLKRSHELDLDENPDSDFDNDGSLLGFKHGSGQKYGGISNFSHRRVRYLQKNMKQKSKSLDMRRQINMKNKHIFFTEESEKTGFKKSRTLSKVEKFLKWVKEPVDEEASPESVSHNNMQDTCTSSGSEEPEVSVEKGDDPVEMSEAEPGQHPAVCPAGEVGAETHDGTSPEAAGTDTEGCVPQAASDPRQEEAEAESQKKKKKKKKNKKELNLPPDIAAVPELVKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSLESGTIVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEIYGVVDKIEFICGDFLQLASSLKADVVFLSPPWGGPDYATAEIFDISTMMSPDGFEIFRLAQKITNNIVFFLPRNADTDQVASLAGPGGQVEIEQNFLNNRLKTITAYFGDLIRRSTSES", "length": 853, "header": "tr|F1N1K9-1|F1N1K9_BOVIN Isoform 1 of Trimethylguanosine synthase OS=Bos taurus OX=9913 GN=TGS1 PE=3 SV=3 CANONICAL=F1N1K9-1" }, "isoforms": [ { "isoform_ac": "F1N1K9-1", "url": "https://www.uniprot.org/uniprotkb/F1N1K9/entry", "sequence": { "sequence": "MYCKKWRPVAEMCLFLEDLREGSRILCLCSRAFVEDRKLYNLGLKGYYVKDDDNSAGEQATEEEEGGHSQGPAEPHDNRCPDPDESELDSEAELMRSMGLPLQFGRMSAHKNFEESMNTRNKVKIMKKKKKKHQKKYLDEIKRESWRQCEEDDVSASDDPSSSENENTRKYKLQSQKGTEAESFPVENTVGPKLEITEMWEKYWNEYGGGLLWQSWQEKHADQTLCPEPWNVPDTKEEWEQHYSQMYWYYLEQFQYWEAQGWTFDASQSQDTDPGGSEIEVDNKKDENHMKADELFSPSLSVGSESSSSSDKDHSEILNGISNLSLNSEKVEQRQLDPSLSCDGRQCLSEVPSRRECPASGHSEPSHGGNTESSLSGSRSTDQPAQDSQESSEANTVRDGRHRSGTDGDESGDDPPEEKRSKLKRSHELDLDENPDSDFDNDGSLLGFKHGSGQKYGGISNFSHRRVRYLQKNMKQKSKSLDMRRQINMKNKHIFFTEESEKTGFKKSRTLSKVEKFLKWVKEPVDEEASPESVSHNNMQDTCTSSGSEEPEVSVEKGDDPVEMSEAEPGQHPAVCPAGEVGAETHDGTSPEAAGTDTEGCVPQAASDPRQEEAEAESQKKKKKKKKNKKELNLPPDIAAVPELVKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSLESGTIVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEIYGVVDKIEFICGDFLQLASSLKADVVFLSPPWGGPDYATAEIFDISTMMSPDGFEIFRLAQKITNNIVFFLPRNADTDQVASLAGPGGQVEIEQNFLNNRLKTITAYFGDLIRRSTSES", "length": 853, "header": "tr|F1N1K9-1|F1N1K9_BOVIN Isoform 1 of Trimethylguanosine synthase OS=Bos taurus OX=9913 GN=TGS1 PE=3 SV=3 CANONICAL=F1N1K9-1" }, "locus": { "chromosome": "14", "start_pos": 23095663, "end_pos": 23070332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007749.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007749.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007749.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007749.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" }, { "id": "R-BTA-400206", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-400206", "resource": "Reactome", "description": "Regulation of lipid metabolism by PPARalpha" }, { "id": "R-BTA-9707564", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "resource": "Reactome", "description": "Cytoprotection by HMOX1" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "7-methylguanosine cap hypermethylation", "id": "GO:0036261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036261", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA cap trimethylguanosine synthase activity", "id": "GO:0071164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071164", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "F1N1K9", "url": "https://www.uniprot.org/uniprotkb/F1N1K9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "78471", "name": "", "equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "78471", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/78471" } ] }, { "id": "78475", "name": "", "equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "78475", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/78475" } ] }, { "id": "78479", "name": "", "equation": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "78479", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/78479" } ] }, { "id": "78507", "name": "", "equation": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "78507", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/78507" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1K9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 853, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1K9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1K9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 323, "end_pos": 325 }, { "start_pos": 461, "end_pos": 463 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1L2-1", "uniprot_ac": "F1N1L2", "uniprot_id": "F1N1L2_BOVIN", "mass": { "chemical_mass": 37697.0, "monoisotopic_mass": 37697.0 }, "refseq": {}, "gene_names": [ { "name": "OR2B2", "type": "recommended", "evidence": [ { "id": "F1N1L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N1L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2B2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2", "locus": { "chromosome": "23", "start_pos": 30820412, "end_pos": 30821817, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005885", "url": "https://www.ensembl.org/id/ENSBTAG00000005885" } ] } } ], "crossref": [ { "id": "F1N1L2", "url": "https://alphafold.ebi.ac.uk/entry/F1N1L2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005885", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005885", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PLCGHRE", "url": "https://omabrowser.org/oma/group/PLCGHRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1L2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1L2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRINESVPQEFILLGFSDRPWLELPLFVVFLISYILTILGNLAIIIVSRLDSKLHTPMYFFLTNLSLLDLCYTTSTVPQMLVNIRSIRKVISYGGCVAQLFISLALGSTECLLLAVMSFDRFVAICRPLHYSVIMHQRLCLQLAAMSWVSGFSNSVLQSTLTLQMPLCGHNEVDHFFCEVPALLRLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIQSVEGRRKAFGTCGSHLIVVSLFYGTAIYMYLQPPSPASKDRGKMVSLFYGIITPMLNPLIYTLRNKDVKGAFKRLIARILLIKKYPSDRPYRTEVHKAIQSPLLL", "length": 334, "header": "tr|F1N1L2-1|F1N1L2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2B2 PE=3 SV=3 CANONICAL=F1N1L2-1" }, "isoforms": [ { "isoform_ac": "F1N1L2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1L2/entry", "sequence": { "sequence": "MNRINESVPQEFILLGFSDRPWLELPLFVVFLISYILTILGNLAIIIVSRLDSKLHTPMYFFLTNLSLLDLCYTTSTVPQMLVNIRSIRKVISYGGCVAQLFISLALGSTECLLLAVMSFDRFVAICRPLHYSVIMHQRLCLQLAAMSWVSGFSNSVLQSTLTLQMPLCGHNEVDHFFCEVPALLRLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIQSVEGRRKAFGTCGSHLIVVSLFYGTAIYMYLQPPSPASKDRGKMVSLFYGIITPMLNPLIYTLRNKDVKGAFKRLIARILLIKKYPSDRPYRTEVHKAIQSPLLL", "length": 334, "header": "tr|F1N1L2-1|F1N1L2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2B2 PE=3 SV=3 CANONICAL=F1N1L2-1" }, "locus": { "chromosome": "23", "start_pos": 30821817, "end_pos": 30820415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007736.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007736.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007736.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007736.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3HPW2-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100762344", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNLANESIPEEFILLGFSDRPWLELPLFVVFLVSYILTIFGNMMIILVSRLDSKLHTPMYFFLTNLSLLDLCYTTSTVPQMLINICSTQKVISYGGCVAQLFIFLALGSTECLLLGVMSFDRFVAICQPLHYSVIMHQRRCLQLAAACWISGFSNSVLQSTWTLQMPRCGHKEVDHFFCEVPALLKLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIRSAEGRRKAFGTCGSHLIVVVLFYGTAIYMYLQPPSPASKDRGKMVSLFYGIITPMLNPLIYTLRNKEVKGAFKRLMARVFLIKK", "length": 313 }, "evidence": [ { "id": "F1N1L2", "url": "https://omabrowser.org/oma/group/F1N1L2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q63394-1", "protein_name": "Olfactory receptor", "gene_name": "Or2b2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVANESISREFILLGFSDRPWLELPLFVVFLVSYILTIFGNMMIILVSRLDSKLHTPMYFFLTNLSLLDLCYTTSTVPQMLINICSTRKVISYGGCVVQLFIFLSLGSTECFLLGVMSLDRFLAICRPLHYSVIMHQRRCLHLAAACWISGFSNSVLQSTWTLQMPLCGHKEVDHFFCEVPALLKLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLKIRSAECRRKAFGTCGSHLIVVVLFYGTAIYMYLQPPSPSSKDRGKMVSLFYGIITPMLNPLIYTLRNEEVKGAFKRLMKRIILIGK", "length": 313 }, "evidence": [ { "id": "F1N1L2", "url": "https://omabrowser.org/oma/group/F1N1L2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TQU5-1", "protein_name": "Olfactory receptor", "gene_name": "Or2b2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVANESISREFILLGFSDRPWLELPLFVVFLVSYILTIFGNMMIILVSRLDSKLHTPMYFFLTNLSLLDLCYTTSTVPQMLINICSTRKVISYGGCVAQLFIFLALGSTECFLLGVMSFDRFVAICRPLHYSVIMHQRRCLQLAAACWISGFSNSVLQSTWTLQMPLCGHKEVDHFFCEVPALLKLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIRSAEGRRKAFGTCGSHLIVVVLFYGTAIYMYLQPPSPTSKDRGKMVSLFYGIITPMLNPLIYTLRNKEVKGAFKRLVTRIILSRK", "length": 313 }, "evidence": [ { "id": "F1N1L2", "url": "https://omabrowser.org/oma/group/F1N1L2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GZK3-1", "protein_name": "Olfactory receptor 2B2", "gene_name": "OR2B2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNWVNKSVPQEFILLVFSDQPWLEIPPFVMFLFSYILTIFGNLTIILVSHVDFKLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNICNTRKVISYGGCVAQLFIFLALGSTECLLLAVMCFDRFVAICRPLHYSIIMHQRLCFQLAAASWISGFSNSVLQSTWTLKMPLCGHKEVDHFFCEVPALLKLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIQSAEGQRKAFGTCGSHLIVVSLFYGTAISMYLQPPSPSSKDRGKMVSLFCGIIAPMLNPLIYTLRNKEVKEAFKRLVAKSLLNQEIRNMQMISFAKDTVLTYLTNFSASCPIFVITIENYCNLPQRKFP", "length": 357 }, "evidence": [ { "id": "F1N1L2", "url": "https://omabrowser.org/oma/group/F1N1L2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N1L2", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1L2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 334, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1L2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1L2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1L3-1", "uniprot_ac": "F1N1L3", "uniprot_id": "F1N1L3_BOVIN", "mass": { "chemical_mass": 34894.0, "monoisotopic_mass": 34894.0 }, "refseq": { "ac": "NP_001376953", "name": "olfactory receptor family 10 subfamily P member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376953" }, "gene_names": [ { "name": "OR10P1", "type": "recommended", "evidence": [ { "id": "F1N1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" } ] }, { "name": "OR10P1", "type": "synonym", "evidence": [ { "id": "NP_001376953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376953" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 10 subfamily P member 1", "type": "synonym", "evidence": [ { "id": "NP_001376953", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376953" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376953" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10P1", "url": "https://www.uniprot.org/uniprotkb/F1N1L3", "locus": { "chromosome": "5", "start_pos": 57626515, "end_pos": 57627453, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031031", "url": "https://www.ensembl.org/id/ENSBTAG00000031031" } ] } } ], "crossref": [ { "id": "F1N1L3", "url": "https://alphafold.ebi.ac.uk/entry/F1N1L3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520305", "url": "https://www.ncbi.nlm.nih.gov/gene/520305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HMVKRQV", "url": "https://omabrowser.org/oma/group/HMVKRQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1L3", "url": "https://www.orthodb.org/?gene=F1N1L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376953", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1L3-1", "url": "https://www.uniprot.org/uniprotkb/F1N1L3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKENQTLPEFLLLGFSDLRALQGPLFWGVLLVYLVTLLGNSLIILLTQASPTLHAPMYFFLRHLSLVELLYTTDIVPRTLADLAFPHPRAISFWGCAAQMYVFIVLGISECCLLTAMAYDRYAAICQPLHYSTLMSWRACMAMVGISWLMGIITATTHSSLIFTLPFPSRPVIPHFLCDILPVLRLASAGKHRSEVSVMMATVVFIMVPFSLIVTSYAHILSAILAMASTLSRRKVFSTCSSHLLVVFLFFGTASITYIRPRAGSSVTMNRILSLFYTVITPMLNPIIYTLRNKEVTRALWHVVKRQVPSP", "length": 312, "header": "tr|F1N1L3-1|F1N1L3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10P1 PE=3 SV=2 CANONICAL=F1N1L3-1" }, "isoforms": [ { "isoform_ac": "F1N1L3-1", "url": "https://www.uniprot.org/uniprotkb/F1N1L3/entry", "sequence": { "sequence": "MAKENQTLPEFLLLGFSDLRALQGPLFWGVLLVYLVTLLGNSLIILLTQASPTLHAPMYFFLRHLSLVELLYTTDIVPRTLADLAFPHPRAISFWGCAAQMYVFIVLGISECCLLTAMAYDRYAAICQPLHYSTLMSWRACMAMVGISWLMGIITATTHSSLIFTLPFPSRPVIPHFLCDILPVLRLASAGKHRSEVSVMMATVVFIMVPFSLIVTSYAHILSAILAMASTLSRRKVFSTCSSHLLVVFLFFGTASITYIRPRAGSSVTMNRILSLFYTVITPMLNPIIYTLRNKEVTRALWHVVKRQVPSP", "length": 312, "header": "tr|F1N1L3-1|F1N1L3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10P1 PE=3 SV=2 CANONICAL=F1N1L3-1" }, "locus": { "chromosome": "5", "start_pos": 57627453, "end_pos": 57626518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007734.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007734.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007734.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007734.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520305", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AVD4-1", "protein_name": "Olfactory receptor", "gene_name": "OR10P1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARENQTLPEFLLLGFSDLRALQGPLFWVVLLVYLVTLLGNSLIILLTRASPALHSPMYFFLRHLSVVEILYTTTIVPRTLADLASPHPRAISFQGCAAQMYVFIVLGISECCLLTAMAYDRHAAICRPLHYSTLMRGQACMVMVAVSWLMGIVTATTHSSLIFTLSFPSHPIIPHFFCDILPVLRRASAGKHGSEISVMTATVAFIMVPFSLIVTSYTRILGAILAMTSTRSRHKVFSTCSSHLLAVLLFFGTASVTYIRPQAGSSVTTDRILSLFYTVITPMLNPIIYTLRNKEVTTALRLMVKRQVPSP", "length": 312 }, "evidence": [ { "id": "F1N1L3", "url": "https://omabrowser.org/oma/group/F1N1L3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NGE3-1", "protein_name": "Olfactory receptor 10P1", "gene_name": "OR10P1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGENHTTLPEFLLLGFSDLKALQGPLFWVVLLVYLVTLLGNSLIILLTQVSPALHSPMYFFLRQLSVVELFYTTDIVPRTLANLGSPHPQAISFQGCAAQMYVFIVLGISECCLLTAMAYDRYVAICQPLRYSTLLSPRACMAMVGTSWLTGIITATTHASLIFSLPFRSHPIIPHFLCDILPVLRLASAGKHRSEISVMTATIVFIMIPFSLIVTSYIRILGAILAMASTQSRRKVFSTCSSHLLVVSLFFGTASITYIRPQAGSSVTTDRVLSLFYTVITPMLNPIIYTLRNKDVRRALRHLVKRQRPSP", "length": 313 }, "evidence": [ { "id": "F1N1L3", "url": "https://omabrowser.org/oma/group/F1N1L3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VGJ1-1", "protein_name": "Olfactory receptor", "gene_name": "Or10p1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEENQTTTTEFLLLGFSDLRALQGPLFWLVLLVYLITFLGNSLIIFLTQTSPVLHSPMYFFLRHLSMVELLYTTDIVPRVLADLTSSHPQAISFRSCAAQMYFFIVLGISECCLLTAMAYDRYAAICQPLHYSTLMNHRACIAMVGTSWIMGIITATTHSSLIFTLPFPSRPIIPHFLCDILPVLRLASAGKHRSEISVMTATVVFIMIPFSLIVTSYARILGAILAIASSQSRRKVFSTCSSHLLVVSLFFGTASITYIRPRAGSSVTTDRILSLFYTVVTPMLNPIIYTLRNKEVIGALKHMKRQVP", "length": 310 }, "evidence": [ { "id": "F1N1L3", "url": "https://omabrowser.org/oma/group/F1N1L3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N1L3", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1L3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1L3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1L3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1L3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1N8-1", "uniprot_ac": "F1N1N8", "uniprot_id": "F1N1N8_BOVIN", "mass": { "chemical_mass": 31163.0, "monoisotopic_mass": 31163.0 }, "refseq": { "ac": "NP_001192836", "name": "gap junction beta-5 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836" }, "gene_names": [ { "name": "GJB5", "type": "recommended", "evidence": [ { "id": "F1N1N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" } ] }, { "name": "CXNA", "type": "synonym", "evidence": [ { "id": "NP_001192836", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836" } ] }, { "name": "GJB5", "type": "synonym", "evidence": [ { "id": "NP_001192836", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836" } ] } ], "protein_names": [ { "name": "Gap junction protein", "type": "recommended", "evidence": [ { "id": "F1N1N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1N8/entry#names_and_taxonomy" } ] }, { "name": "connexin A", "type": "synonym", "evidence": [ { "id": "NP_001192836", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836" } ] }, { "name": "gap junction beta-5 protein", "type": "synonym", "evidence": [ { "id": "NP_001192836", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836" } ] }, { "name": "gap junction protein, beta 5, 31.1kDa", "type": "synonym", "evidence": [ { "id": "NP_001192836", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836" } ] } ], "function": [ { "annotation": "Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response.", "evidence": [ { "database": "UniProtKB", "id": "F1N1N8", "url": "https://www.uniprot.org/uniprotkb/F1N1N8#function" }, { "database": "UniProtKB", "id": "RU000630", "url": "https://www.uniprot.org/uniprotkb/RU000630#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1N8", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GJB5", "url": "https://www.uniprot.org/uniprotkb/F1N1N8", "locus": { "chromosome": "3", "start_pos": 110929602, "end_pos": 110938220, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005717", "url": "https://www.ensembl.org/id/ENSBTAG00000005717" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005717", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524030", "url": "https://www.ncbi.nlm.nih.gov/gene/524030", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524030", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524030", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWSIFEG", "url": "https://omabrowser.org/oma/group/NWSIFEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1N8", "url": "https://www.orthodb.org/?gene=F1N1N8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-190861", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192836", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N1N8", "url": "https://www.uniprot.org/uniprotkb/F1N1N8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1N8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1N8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNWGIFEGLLSGANKYSTAFGRVWLSLVFIFRVLVYLVTAERVWSDDHKDFDCDTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRQAREKKHQEAIGKDGGRLYLDPGKKRGGLWWTYVCSLVFKAGVDATFLYVFHSIYPRYTLPRVVKCQVAPCPNVVDCFISKPEEKNIFTLFMVITALVCIVLNLVELAYLVSKRCRECLEARKARSESLDHRLDWVTSSSKQGDLLSGDLIFLDSDVPPPLLPDHPQDHVKKTML", "length": 273, "header": "tr|F1N1N8-1|F1N1N8_BOVIN Isoform 1 of Gap junction protein OS=Bos taurus OX=9913 GN=GJB5 PE=3 SV=2 CANONICAL=F1N1N8-1" }, "isoforms": [ { "isoform_ac": "F1N1N8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1N8/entry", "sequence": { "sequence": "MNWGIFEGLLSGANKYSTAFGRVWLSLVFIFRVLVYLVTAERVWSDDHKDFDCDTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRQAREKKHQEAIGKDGGRLYLDPGKKRGGLWWTYVCSLVFKAGVDATFLYVFHSIYPRYTLPRVVKCQVAPCPNVVDCFISKPEEKNIFTLFMVITALVCIVLNLVELAYLVSKRCRECLEARKARSESLDHRLDWVTSSSKQGDLLSGDLIFLDSDVPPPLLPDHPQDHVKKTML", "length": 273, "header": "tr|F1N1N8-1|F1N1N8_BOVIN Isoform 1 of Gap junction protein OS=Bos taurus OX=9913 GN=GJB5 PE=3 SV=2 CANONICAL=F1N1N8-1" }, "locus": { "chromosome": "3", "start_pos": 110932152, "end_pos": 110931334, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007517.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007517.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007517.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007517.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524030", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524030", "resource": "KEGG Pathway" }, { "id": "R-BTA-190861", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "resource": "Reactome", "description": "Gap junction assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U3Y9-1", "protein_name": "Gap junction protein", "gene_name": "GJB5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNWSVFEGLLSGVNRYSTAFGRIWLSLVFIFRLLVYVVAAERVWSDDHKDFDCNTRQPGCTNVCYDHFFPISHIRLWALQLILVTCPSLLVIMHVAYRQAKALQHRAERGDSYRSRFPNPGKKRGGLWWTYLFSLIVKAGVDMVFLYIFYHIYRNYTLPRLVKCQLPPCPNIVDCFISRPTEKTIFTLFMVVTTCICIVLSLVEAAYLIGKRCRERLQAGTGESHCHSHDCAESASTGGQVFHGVGYKAPTASIPSASIPTTSIPTASIPTTSIPTASIPTTSIPTTLPEQEKTPS", "length": 296 }, "evidence": [ { "id": "F1N1N8", "url": "https://omabrowser.org/oma/group/F1N1N8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1VSW7-1", "protein_name": "Gap junction protein", "gene_name": "GJB5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNWGVFEGLLSGVNKYSTAFGRVWLSLVFIFRLLVYLVTAERVWSDDHKDFSCDTRQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREAREKKHRERAGKDGGRLYLDPGKKRGGLWWTYVCSLVFKAGVDAAFLYVFHLFYPKYTLPRVVKCHAAPCPNTVDCFISKPAEKNIFTLFMVITAVICILLNLVELAYLVSKRCRECLAERKARAKGVGHRLDWTTSSTKQDDLLLGDLIFLGSDVPPPLLPDHPRDHVEKTTL", "length": 273 }, "evidence": [ { "id": "F1N1N8", "url": "https://omabrowser.org/oma/group/F1N1N8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H9T2-1", "protein_name": "Gap junction protein", "gene_name": "Gjb5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTVERVWGEDQKDFDCNTRQPGCTNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKRYQEEVGKGHLYLYPGKKRGGLWWTYVCSLLFKAGIDIVFLYVFHVFYPKYTLPSVVKCHATPCPNIVDCFISKPSEKNIFIIFMLITAIICILLNLVELAYLVIKRCSECMESRRALTAHPEHDPNWVNSSSKQKDLLAGDLIFLGSDTHPPLLPDHPRAHVKKTIL", "length": 271 }, "evidence": [ { "id": "F1N1N8", "url": "https://omabrowser.org/oma/group/F1N1N8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95377-1", "protein_name": "Gap junction beta-5 protein", "gene_name": "GJB5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL", "length": 273 }, "evidence": [ { "id": "F1N1N8", "url": "https://omabrowser.org/oma/group/F1N1N8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q02739-1", "protein_name": "Gap junction beta-5 protein", "gene_name": "Gjb5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQEKIGEGYLYPNPGKKRGGLWWTYVFSLSFKATIDIIFLYLFHAFYPRYTLPSMVKCHAEPCPNTVDCFIAKPSEKNIFIVFMVVTAVICILLNLVELIYLVIKRCSECAQLRRPPTAHAKNDPNWANSPSKEKDFLSCDLIFLGSDAHPPLLPDRPRAHVKKTIL", "length": 271 }, "evidence": [ { "id": "F1N1N8", "url": "https://omabrowser.org/oma/group/F1N1N8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "F1N1N8", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "connexin complex", "id": "GO:0005922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922", "evidence": [ { "database": "UniProtKB", "id": "F1N1N8", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gap junction channel activity", "id": "GO:0005243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243", "evidence": [ { "database": "UniProtKB", "id": "F1N1N8", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" }, { "id": "SM00037", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Connexin N-terminal", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 75, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N1N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1N8" }, { "id": "SM01089", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Connexin cysteine-rich", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 208, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1P2-1", "uniprot_ac": "F1N1P2", "uniprot_id": "F1N1P2_BOVIN", "mass": { "chemical_mass": 22620.0, "monoisotopic_mass": 22620.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "High mobility group protein B3", "type": "recommended", "evidence": [ { "id": "F1N1P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1P2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2#function" }, { "database": "UniProtKB", "id": "ARBA00055449", "url": "https://www.uniprot.org/uniprotkb/ARBA00055449#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1N1P2", "locus": {} } ], "crossref": [ { "id": "F1N1P2", "url": "https://alphafold.ebi.ac.uk/entry/F1N1P2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015315", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015315", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21978", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21978", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21979", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21979", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CAYAFFV", "url": "https://omabrowser.org/oma/group/CAYAFFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1P2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1P2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAISDPKKPKGKMCAYAFFVQMCREEHKKKNSEVPVNFAEFSKKCSERWKTMSRKEKSKFDEMAKAYKMHYDQEMKDYGPARGGKKKDPKAPKRLPSGCLLFCSEFHPKIKSTHPGISIRDVAKKLGEMWNNLSDSEKQPYINKAAKLKKYEKDAADHKSRGKFDGTKGPAKVAGKMVEEEDKEDEEEEEGRRRMN", "length": 196, "header": "tr|F1N1P2-1|F1N1P2_BOVIN Isoform 1 of High mobility group protein B3 OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1N1P2-1" }, "isoforms": [ { "isoform_ac": "F1N1P2-1", "url": "https://www.uniprot.org/uniprotkb/F1N1P2/entry", "sequence": { "sequence": "MAISDPKKPKGKMCAYAFFVQMCREEHKKKNSEVPVNFAEFSKKCSERWKTMSRKEKSKFDEMAKAYKMHYDQEMKDYGPARGGKKKDPKAPKRLPSGCLLFCSEFHPKIKSTHPGISIRDVAKKLGEMWNNLSDSEKQPYINKAAKLKKYEKDAADHKSRGKFDGTKGPAKVAGKMVEEEDKEDEEEEEGRRRMN", "length": 196, "header": "tr|F1N1P2-1|F1N1P2_BOVIN Isoform 1 of High mobility group protein B3 OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1N1P2-1" }, "locus": { "chromosome": "24", "start_pos": 21817028, "end_pos": 21816441, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020361.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020361.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052990.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052990.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ACD7-1", "protein_name": "High mobility group protein B3", "gene_name": "Hmgb3l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKGDPKKPKGKMSAYAFFVQTCREEHKTKNPEVPVNFAEFSKKCSERWKTMSSKEKSKFDEMAKADKVRYGREMKDYESAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSANPGISIEDVVKKLGEMWNNLSDSEKQPYMTKAAKLKEKYEKDVADYKSNGQFDGAKGPAKVARKTVEEEEEEKEEEEEEEQEDE", "length": 198 }, "evidence": [ { "id": "F1N1P2", "url": "https://omabrowser.org/oma/group/F1N1P2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding, bending", "id": "GO:0008301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008301", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" }, { "name": "DNA metabolic process", "id": "GO:0006259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006259", "evidence": [ { "database": "UniProtKB", "id": "F1N1P2", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1P2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 196, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1P2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1P2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1P2" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 79, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1P6-1", "uniprot_ac": "F1N1P6", "uniprot_id": "F1N1P6_BOVIN", "mass": { "chemical_mass": 42500.0, "monoisotopic_mass": 42500.0 }, "refseq": {}, "gene_names": [ { "name": "MGC157408", "type": "recommended", "evidence": [ { "id": "F1N1P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1P6" } ] } ], "protein_names": [ { "name": "Pregnancy-associated glycoprotein", "type": "synonym", "evidence": [ { "id": "F1N1P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1P6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1P6", "url": "https://www.uniprot.org/uniprotkb/F1N1P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MGC157408", "url": "https://www.uniprot.org/uniprotkb/F1N1P6", "locus": { "chromosome": "29", "start_pos": 38854881, "end_pos": 38864063, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047892", "url": "https://www.ensembl.org/id/ENSBTAG00000047892" } ] } } ], "crossref": [ { "id": "F1N1P6", "url": "https://alphafold.ebi.ac.uk/entry/F1N1P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047892", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047892", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RRECTAM", "url": "https://omabrowser.org/oma/group/RRECTAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1P6", "url": "https://www.orthodb.org/?gene=F1N1P6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47966:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47966:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N1P6", "url": "https://www.uniprot.org/uniprotkb/F1N1P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1P6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKWLVVLGLVAFSECIVKIPLRRVKTMRKTLSGKNMLNNFLKEHAYRLSQISFRGSNLTSHPLRNIKDLVYLANITIGTPPQEFQVFLDTGSSDLWVPSDFCTSPACSKHVRFRHLQSSTFRLTNKTFSITYGSGRMKGVVAHDTVRIGDLVSTDQPFGLSVEEYGFDHIPFDGVLGLNYPKISSSGAIPIFDKLKNQGAISEPVFAFYLSKDEQEGSVVMFGGVDHRYYKGKLNWVPLIPSGNWIIHMHSISIERKVIACSGRCMAFVDTGTAFIEGPKPLVDNMQKLIGAKPSGSKHYVSCSAVNTLPSIIFTINGINYPVPGRAYILKDYRGRCYTTFQESPLSPSIEFWILGDVFVRLYFTVFDRGNDRIGLARAV", "length": 380, "header": "tr|F1N1P6-1|F1N1P6_BOVIN Isoform 1 of Pregnancy-associated glycoprotein OS=Bos taurus OX=9913 GN=MGC157408 PE=3 SV=2 CANONICAL=F1N1P6-1" }, "isoforms": [ { "isoform_ac": "F1N1P6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1P6/entry", "sequence": { "sequence": "MKWLVVLGLVAFSECIVKIPLRRVKTMRKTLSGKNMLNNFLKEHAYRLSQISFRGSNLTSHPLRNIKDLVYLANITIGTPPQEFQVFLDTGSSDLWVPSDFCTSPACSKHVRFRHLQSSTFRLTNKTFSITYGSGRMKGVVAHDTVRIGDLVSTDQPFGLSVEEYGFDHIPFDGVLGLNYPKISSSGAIPIFDKLKNQGAISEPVFAFYLSKDEQEGSVVMFGGVDHRYYKGKLNWVPLIPSGNWIIHMHSISIERKVIACSGRCMAFVDTGTAFIEGPKPLVDNMQKLIGAKPSGSKHYVSCSAVNTLPSIIFTINGINYPVPGRAYILKDYRGRCYTTFQESPLSPSIEFWILGDVFVRLYFTVFDRGNDRIGLARAV", "length": 380, "header": "tr|F1N1P6-1|F1N1P6_BOVIN Isoform 1 of Pregnancy-associated glycoprotein OS=Bos taurus OX=9913 GN=MGC157408 PE=3 SV=2 CANONICAL=F1N1P6-1" }, "locus": { "chromosome": "29", "start_pos": 38864017, "end_pos": 38855038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007506.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007506.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007506.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007506.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1N1P6", "url": "https://www.uniprot.org/uniprotkb/F1N1P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N1P6", "url": "https://www.uniprot.org/uniprotkb/F1N1P6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "F1N1P6", "url": "https://www.uniprot.org/uniprotkb/F1N1P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1P6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 380, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1P6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1P6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1P6" }, { "id": "PS51767", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51767" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase A1", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 377, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1R7-1", "uniprot_ac": "F1N1R7", "uniprot_id": "F1N1R7_BOVIN", "mass": { "chemical_mass": 50138.0, "monoisotopic_mass": 50138.0 }, "refseq": {}, "gene_names": [ { "name": "ENPP7", "type": "recommended", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ] } ], "protein_names": [ { "name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 7", "type": "recommended", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.12", "type": "synonym", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7/entry#names_and_taxonomy" } ] }, { "name": "Alkaline sphingomyelin phosphodiesterase", "type": "synonym", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7/entry#names_and_taxonomy" } ] }, { "name": "Intestinal alkaline sphingomyelinase", "type": "synonym", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ENPP7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7", "locus": { "chromosome": "19", "start_pos": 52794693, "end_pos": 52801584, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001965", "url": "https://www.ensembl.org/id/ENSBTAG00000001965" } ] } } ], "crossref": [ { "id": "F1N1R7", "url": "https://alphafold.ebi.ac.uk/entry/F1N1R7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001965", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001965", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16018", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16018", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10151:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10151:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9840310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "19253", "url": "https://www.rhea-db.org/rhea/19253", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "41119", "url": "https://www.rhea-db.org/rhea/41119", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63380", "url": "https://www.rhea-db.org/rhea/63380", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63384", "url": "https://www.rhea-db.org/rhea/63384", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAPAVFLAVALATLLAPASGAPVRQQASRNKLLLVSFDGFRWNYDQDVDTPNLDAMALDGVKARYMTPAFITLTSPCHFTLVTGKYVENHGVVHNMFYNTSSKVKWPYHTTLGIQKWWDNGSLPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTLSRKEGILHNFKDEAEWRANIDTVMTWFTDEGLDLVTLYFGEPDSTGHRYGPESQERKEIVMQVDRTVGYLRDSIRKSGLESSLNLLILSDHGMTTVNKTASDLVEFHKFSNFSFKDIEFELLDYGPNGMLLPKEGMLEKVYEALKDAHPRLHVYKKEFFPKSFHYANHSRITPLLMYSDPGYVIHGRVNVQFNNGEHGFDNEVMDMKTIFRAVGPSFKKGLEVEPFESVHVYELMCKLLGIVPEANDGLLSTLLPILQETTTTPSGSALLPSGWPPLVTGLLVAATLLVEVA", "length": 448, "header": "tr|F1N1R7-1|F1N1R7_BOVIN Isoform 1 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 OS=Bos taurus OX=9913 GN=ENPP7 PE=4 SV=4 CANONICAL=F1N1R7-1" }, "isoforms": [ { "isoform_ac": "F1N1R7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R7/entry", "sequence": { "sequence": "MGAPAVFLAVALATLLAPASGAPVRQQASRNKLLLVSFDGFRWNYDQDVDTPNLDAMALDGVKARYMTPAFITLTSPCHFTLVTGKYVENHGVVHNMFYNTSSKVKWPYHTTLGIQKWWDNGSLPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTLSRKEGILHNFKDEAEWRANIDTVMTWFTDEGLDLVTLYFGEPDSTGHRYGPESQERKEIVMQVDRTVGYLRDSIRKSGLESSLNLLILSDHGMTTVNKTASDLVEFHKFSNFSFKDIEFELLDYGPNGMLLPKEGMLEKVYEALKDAHPRLHVYKKEFFPKSFHYANHSRITPLLMYSDPGYVIHGRVNVQFNNGEHGFDNEVMDMKTIFRAVGPSFKKGLEVEPFESVHVYELMCKLLGIVPEANDGLLSTLLPILQETTTTPSGSALLPSGWPPLVTGLLVAATLLVEVA", "length": 448, "header": "tr|F1N1R7-1|F1N1R7_BOVIN Isoform 1 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 OS=Bos taurus OX=9913 GN=ENPP7 PE=4 SV=4 CANONICAL=F1N1R7-1" }, "locus": { "chromosome": "19", "start_pos": 52801434, "end_pos": 52795697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002552.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002552.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002552.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002552.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 68, "start_aa": "Thr", "end_pos": 68, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr68", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9840310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" }, { "name": "phosphoric diester hydrolase activity", "id": "GO:0008081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008081", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" }, { "name": "sphingomyelin phosphodiesterase activity", "id": "GO:0004767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004767", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" }, { "name": "sphingomyelin metabolic process", "id": "GO:0006684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006684", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" }, { "name": "negative regulation of DNA replication", "id": "GO:0008156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008156", "evidence": [ { "database": "UniProtKB", "id": "F1N1R7", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19253", "name": "", "equation": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MZY8-1", "Q0VD19-1", "F1N1R7-1" ], "evidence": [ { "id": "19253", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19253" } ] }, { "id": "41119", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5C8-1", "A0A3Q1MZY8-1", "F1N588-1", "F1N6X9-1", "F1N1R7-1" ], "evidence": [ { "id": "41119", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41119" } ] }, { "id": "63380", "name": "", "equation": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N1R7-1" ], "evidence": [ { "id": "63380", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63380" } ] }, { "id": "63384", "name": "", "equation": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N1R7-1" ], "evidence": [ { "id": "63384", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63384" } ] }, { "id": "R-BTA-1640164", "name": "ENPP7 hydrolyzes sphingomyelin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-429776" ], "output_participant_list": [ "R-ALL-1610735" ], "enzyme_list": [ "F1N1R7-1" ], "evidence": [ { "id": "R-BTA-1640164", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1640164" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1610735", "participant_name": "ChoP [plasma membrane]", "crossref": [ { "id": "295975", "database": "ChEBI", "url": "" }, { "id": "ZINC000001532692", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-429776", "participant_name": "SPHM d18:1 [plasma membrane]", "crossref": [ { "id": "17636", "database": "ChEBI", "url": "" }, { "id": "HMDB0012096", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0012092", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0012089", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MZY8", "gene_name": "SMPD3", "activity": [ { "ec_number": "3.1.4.12", "activity": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+).", "evidence": [ { "id": "A0A3Q1MZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZY8" } ] }, { "ec_number": "3.1.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1MZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZY8" } ] } ] }, { "uniprot_ac": "F1N1R7", "gene_name": "ENPP7", "activity": [ { "ec_number": "3.1.4.12", "activity": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+).", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ] }, { "ec_number": "3.1.4.12", "activity": "", "evidence": [ { "id": "F1N1R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1R7" } ] } ] }, { "uniprot_ac": "F1N588", "gene_name": "SMPD2", "activity": [ { "ec_number": "3.1.4.12", "activity": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+).", "evidence": [ { "id": "F1N588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N588" } ] }, { "ec_number": "3.1.4.12", "activity": "", "evidence": [ { "id": "F1N588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N588" } ] } ] }, { "uniprot_ac": "F1N5C8", "gene_name": "ENPP6", "activity": [ { "ec_number": "3.1.4.38", "activity": "sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+).", "evidence": [ { "id": "F1N5C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5C8" } ] }, { "ec_number": "3.1.4.38", "activity": "", "evidence": [ { "id": "F1N5C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5C8" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "F1N5C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5C8" } ] } ] }, { "uniprot_ac": "F1N6X9", "gene_name": "SMPD5", "activity": [ { "ec_number": "3.1.4.12", "activity": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+).", "evidence": [ { "id": "F1N6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6X9" } ] }, { "ec_number": "3.1.4.12", "activity": "", "evidence": [ { "id": "F1N6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6X9" } ] } ] }, { "uniprot_ac": "Q0VD19", "gene_name": "SMPD1", "activity": [ { "ec_number": "3.1.4.12", "activity": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+).", "evidence": [ { "id": "Q0VD19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD19" } ] }, { "ec_number": "3.1.4.3", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q0VD19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD19" } ] }, { "ec_number": "3.1.4.3", "activity": "", "evidence": [ { "id": "Q0VD19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD19" } ] }, { "ec_number": "3.1.4.12", "activity": "", "evidence": [ { "id": "Q0VD19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD19" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1R7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 448, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1R7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1R7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.4.12", "ec_name": "a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+).", "evidence": [ { "id": "3.1.4.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12" }, { "id": "3.1.4.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.12" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 68 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 121, "end_pos": 123 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 323, "end_pos": 325 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1T6-1", "uniprot_ac": "F1N1T6", "uniprot_id": "F1N1T6_BOVIN", "mass": { "chemical_mass": 78217.0, "monoisotopic_mass": 78217.0 }, "refseq": {}, "gene_names": [ { "name": "FASTKD2", "type": "recommended", "evidence": [ { "id": "F1N1T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ] } ], "protein_names": [ { "name": "FAST kinase domains 2", "type": "synonym", "evidence": [ { "id": "F1N1T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1T6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FASTKD2", "url": "https://www.uniprot.org/uniprotkb/F1N1T6", "locus": { "chromosome": "2", "start_pos": 95085010, "end_pos": 95064720, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016193", "url": "https://www.ensembl.org/id/ENSBTAG00000016193" } ] } } ], "crossref": [ { "id": "F1N1T6", "url": "https://alphafold.ebi.ac.uk/entry/F1N1T6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016193", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016193", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR010622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FEIRMDS", "url": "https://omabrowser.org/oma/group/FEIRMDS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1T6", "url": "https://www.orthodb.org/?gene=F1N1T6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1T6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1T6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNRAGSFLWNLRQLSTLVPTGRTVRLYPLAFCRPNIAYSNWNRRNLLNTFGNKMHSSTRYLFQDALIFKSEGDGCQTKGISTATVFTVDKLLCPRRLSFDSKHFLVSVSELKKSFHQEASDEDVLTKRRKPALISSTKLSQECNSLSDVLDIFSKAPTFPSSNYFSAMWTIAKRMSEDQKRFEKQLMFNHPAFNQLCEHVMREAKIMYFGDLLFSLHAIVKLGIPQNTLLVQTLLRVVQERINECDEKCLSVLSTILNTMEPCKNVDVLLAGLRMLVDEQVCKIKHVFTLQTVMRSIGKDAPIGLKRKLEMKALKELDQFSVLNCQHMFAVLAAMNHRSIILLNECSKRVTSNIHGCPFKILINILQSCRDLQYINIDLFKGIADYVATTFDIWKLKKVLFLLILFENFGFRPVGLMDLFIKKAADEPGFLNVKSLVGILNVYSSLNHFYKCQTHEFLEVMASALTGSLHHISSENLLNAVCSFCWMNYFPLALINQLLQKDIIDDLLTSGDVERNVHRLHVVATCLKLDDAPCHKDLDLVLPQLPPMTFCPQPKVAAVLSDLLGEGCFSQSVQLPHNYFIDFEIRMDANRSQVLPFSDVDVVTSTDIQRVAVLCVPKSAYCLDSTHPKGYLAMKMRHLKIMGFHVILVNNWEVEKLEMKDAVAFLKTKIYSPKALSSADIHLQSTC", "length": 688, "header": "tr|F1N1T6-1|F1N1T6_BOVIN Isoform 1 of FAST kinase domains 2 OS=Bos taurus OX=9913 GN=FASTKD2 PE=4 SV=1 CANONICAL=F1N1T6-1" }, "isoforms": [ { "isoform_ac": "F1N1T6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1T6/entry", "sequence": { "sequence": "MNNRAGSFLWNLRQLSTLVPTGRTVRLYPLAFCRPNIAYSNWNRRNLLNTFGNKMHSSTRYLFQDALIFKSEGDGCQTKGISTATVFTVDKLLCPRRLSFDSKHFLVSVSELKKSFHQEASDEDVLTKRRKPALISSTKLSQECNSLSDVLDIFSKAPTFPSSNYFSAMWTIAKRMSEDQKRFEKQLMFNHPAFNQLCEHVMREAKIMYFGDLLFSLHAIVKLGIPQNTLLVQTLLRVVQERINECDEKCLSVLSTILNTMEPCKNVDVLLAGLRMLVDEQVCKIKHVFTLQTVMRSIGKDAPIGLKRKLEMKALKELDQFSVLNCQHMFAVLAAMNHRSIILLNECSKRVTSNIHGCPFKILINILQSCRDLQYINIDLFKGIADYVATTFDIWKLKKVLFLLILFENFGFRPVGLMDLFIKKAADEPGFLNVKSLVGILNVYSSLNHFYKCQTHEFLEVMASALTGSLHHISSENLLNAVCSFCWMNYFPLALINQLLQKDIIDDLLTSGDVERNVHRLHVVATCLKLDDAPCHKDLDLVLPQLPPMTFCPQPKVAAVLSDLLGEGCFSQSVQLPHNYFIDFEIRMDANRSQVLPFSDVDVVTSTDIQRVAVLCVPKSAYCLDSTHPKGYLAMKMRHLKIMGFHVILVNNWEVEKLEMKDAVAFLKTKIYSPKALSSADIHLQSTC", "length": 688, "header": "tr|F1N1T6-1|F1N1T6_BOVIN Isoform 1 of FAST kinase domains 2 OS=Bos taurus OX=9913 GN=FASTKD2 PE=4 SV=1 CANONICAL=F1N1T6-1" }, "locus": { "chromosome": "2", "start_pos": 95084925, "end_pos": 95065678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021553.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021553.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021553.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021553.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E1BSE6-1", "protein_name": "FAST kinase domains 2", "gene_name": "FASTKD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNSKMGYLLNAVRYLRRCSPVPRPSAPTSRHVVWTGRHRDCLDNTNCRTLFLNAFPSLRGSPLRFLSHKADAFGVGDEVQQEKSREAAVSEQAPQSSLELEKLEGDAQSFRVKAALDENEQFFNRLHTCACPSDVLDLASESAVSIKQFTNCLTTIWKLLRSMSDDQRRYEKRLVFEHPAFVRLCQQLLRDSRRMTRGDLVFSLHAVVNLGVPQNTLLVQTLLRVCQEKLNQLDNRCMSVLATTLAGMDEDKNVSALQAGLQLLVEQRLPSIRDIFILQNLMKCMGKDAPVFLKKKLEMAVLREIDHLTYPNAHRVFLGLVAMNYCSIPVLNACSKKIQENIHDAPYWQLILILEACHSLQYRNIKLFSAVADYVNSIVCLLDKRQIILFLSAFETLGFQPSELMGVLAEKVTEDSEFLDLKSFLIVLRVYSRLNYVPRGQHLLFYETLHSCLNKYLPQISNAELLKAVYSLCILGYLPHLALNQLLKKDSFEELMSGDLYKEKREMMLHCVRTCMELDSPSFMKPAFVPTEIFSSLVSVTLRKAREALLELLGDENMFRQNVQLPYEYRIDFEIWMDSDTKKVLPITATDSYADRSVQRLAFLFVPPSAFCLGTTHPQGKLAMKKRHLSKLGYHVIPVLNKKFQELTNEGAIEFLKGKIYSENVSPFSEVNLCDNN", "length": 677 }, "evidence": [ { "id": "F1N1T6", "url": "https://omabrowser.org/oma/group/F1N1T6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SHC9-1", "protein_name": "FAST kinase domains 2", "gene_name": "FASTKD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNNRTGSFLWNLRQFSSLVPSGRTVRLYPLGFCRRQIVYLNWNQRSLLNNFGNRMQSSIRCLFQNALIFKSGGDDFQTKGISTATVFTVDRPLCSRRLSFDSNHPLAADNGLKKNFQHKASKEDVLTKGTKPARISCSTLSQECNSLSDVLDIFSKAPRFPSSNYFSAMWIVAKRMSSDQKRFEKQLMFNHPVFSQLCEQAMREAKIMHYDDLLFSLHAIVKLGIPQNTLLVQTLLRVVQERINECDEKCLSVLSTVLEAMEPCKNVDVLRAGFRMLVDQQVWKIERVFTLQTVMKCIGKDAPVGLKRKLEMKALKELDQFSVLNSQHMFKVLAAMNHRSIILLNECSKTVTSNIHGCPFKILISILQSCRDLRYFNIDLLKGIADYVTTTFDIWKLKQVLFLLILFESFGFRPVGLMDLFMKKAADESGSLNVKNLVCILYVYSSLNHVYKCQTHRFLEIMATALTGSLHHISSENLLNVVCSFCLLNHFPLALINQLFQKDTISDLLTSGDVEKHVLKLCTVTACLKLDDAPYPKNIDLVLPEPPSTVLCPNAKVAKVLSSLLGEGCFSKSVQLPHNYYIDFEIRMDTNRSQVLPFSEVDVVTSDTDIQRVAILCIPKSAYCLDSTHPKGNLALKMRHLKAMGFRVILVHNWEMEKLDMKDAVMLLKTKIYSTEALAPADKNLQSTC", "length": 689 }, "evidence": [ { "id": "F1N1T6", "url": "https://omabrowser.org/oma/group/F1N1T6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HDK4-1", "protein_name": "FAST kinase domain-containing protein 2, mitochondrial", "gene_name": "Fastkd2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSNKAYSLLWNTRQLSTLVPRSRFLRIYPPGFCRPEVIPSKWNPRNCLLNGFGEGLQPSVRYLFQGVLKSVDCCTQTKGTGCAAVFKLDRVLCPRRLSSDSEHFLVSDGASDHDLMKINSHHASSEDVLSKKMRPTPVNHDKLVQECNSLSDVLDTFSKAPKFPSSSYFSAMWTIAKRISEDKRRFEIQLMFNHSAFSQLCEQMMRESMIMHYNHLLFSLNAVIKLGVPQNTLMVQTLLRVIQERINECDERCLSILSTVLDTLEPSMNVNALRAGFRILVDQQVWKIEHIFTLQTVMKFIGKDTPLALKKKLEMKTLKELDRFSALNSQHMFEVLAAMDYRSVVLLNECSKKVIDNIHGCPSKVLISILQSCKALRYQNKDLFKRIADYVATTFEIWKLNQVIFFLLGFENLGFRPSALMDKLMEKVMEDPDSLNKKNIVSILHVYSSLNHAHKDQNREFLEAMASALTVYLHHISSENLLSAVYSFCLMNYFPQNLINQLIKKNIINELLTSGDTEKNIPKLHVLNTCLKLDESAYYKAVHIPLPQLPLPLPYPSDRVAEVLSHLLKGEGCFSRNVQLPHNYHIDFEIRMDNNRTQVFSFSDVDATSGTNMQRVAVLCVPKSAYCLDSNHPRGLLAMKIRHLNTMGFHVILINNWELRKLRMEDAVAFVKMKIYSDGAFPTTDTTV", "length": 688 }, "evidence": [ { "id": "F1N1T6", "url": "https://omabrowser.org/oma/group/F1N1T6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5M7V7-1", "protein_name": "FAST kinase domain-containing protein 2, mitochondrial", "gene_name": "Fastkd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNRAHTFLWGIRQFRTSIPRSRALRTYSLVFCKPEVIHSKRNPRNHLLNGFDEGLQPSVRYLFQDIFISKSVAGCTQTRGIIHAAGFKLDRILCPRRLSFDAKHSFVSDGTSDHDLMKTNFHHTSTEDVLTKKMRPTPVNYKKLAQECNSLSDVLDTFSKAPTFPGSNYFLAMWIIAKRISEDKRRFEKQLMFSHPAFNQLCEQMMREAKIMRYDHLLFSLNAIVKLGVPQNSLMVQTLLRTIQERISECDERCLSILSTALVTMEPCMNVNALRAGLRILVDQQVWNINDIFTLQTVMRCIGKDMKALKELGRFSVLNSRHMFEVLAAMDHRSVVLLNECSKIVIDNIHGCPFKVLISILQSCRDLRYQNEDLFKSIADYVATTFDIWKLKHVIFFLLSFETLGFRPPGLMDKLLEKVVQEPGSLTVKNIVSVLHVYSSLNHVHNVQNREFLEALASALTGCLHQISSESLLNAVHSFCMMNYFPLAPINQLIKENIIHELLTSGDTEKNIHKLHVLNTCLKLDESTYKCIHIPLPQLPLTASHPNEKLAEVLSRLLEGDGCFSRNVQLPHNYHIDFEIRMDTNRTQVFSFSEGDASSATNMQRVAVLCVPKSAYCLNSNHLRGLMAMKIRHLNVMGFHVILIHNWELKKLKMEDAVTFVRKKIYSDEALATTDESV", "length": 679 }, "evidence": [ { "id": "F1N1T6", "url": "https://omabrowser.org/oma/group/F1N1T6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q922E6-1", "protein_name": "FAST kinase domain-containing protein 2, mitochondrial", "gene_name": "Fastkd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSKARSLLWTIRRFSTLLPRSRALRIDPLGTCRPEVIHSKWNPRNHRLNVFDEGLQPSVRYLFQDIFISKSVDGCIQTKGISHSAVFKPDRLLCPRRLSFDAKHSFVSDGTSDHDLKKINFHHTSSEDVFTKKVRPTPVNYKKLAQECNSLSDVLDTFSKAPTFPGSNYFLAMWIIAKRISEDKRRFERQLMFSHPAFNQLCEQMMREAKIMHYDHLLFSLNAIVKLGIPQNTLMVQTLLRTIQERINECDERCLSILSTALVSMEPCMNVNALRAGLRILVDQQVWNIKHVFTLQTVMKCIGKDAPSALKKKLEMKALKELGRFSILNSQHMFEVLAAMDLRSVVLLNECSKVVIDNVHGCPFKVLISILQSCRDLRYQNEDLFKSIAEYVATTFDIWKLKQVIFFLLLFETLGFRPPGLMDKLMEKVVQEPGSLNVKNIVSILHVYSSLNHVHKIHNREFLEALASALTGCLHHISSESLLNAVHSFCMMNYFPLAPINQLIKENIINELLTSGDTEKNIHKLHVLNTCLKLDESTYKSVHIPLPQLPLSASQPNEKLAEVLSRLLEGEGRFSRNVPLPHNYHIDFEIRMDTNRTQVFSFSDVDASSATNMQRVAVLCVPKSVYCLNSCHPRGLMAMKIRHLNVMGFHVILIHNWELKKLKMEDAVTFVRKKIYSDEVLPTADTTV", "length": 689 }, "evidence": [ { "id": "F1N1T6", "url": "https://omabrowser.org/oma/group/F1N1T6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NYY8-1", "protein_name": "FAST kinase domain-containing protein 2, mitochondrial", "gene_name": "FASTKD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLTTLKPFGSVSVESKMNNKAGSFFWNLRQFSTLVSTSRTMRLCCLGLCKPKIVHSNWNILNNFHNRMQSTDIIRYLFQDAFIFKSDVGFQTKGISTLTALRIERLLYAKRLFFDSKQSLVPVDKSDDELKKVNLNHEVSNEDVLTKETKPNRISSRKLSEECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDDQKRFEKRLMFSHPAFNQLCEHMMREAKIMQYKYLLFSLHAIVKLGIPQNTILVQTLLRVTQERINECDEICLSVLSTVLEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLEMKALRELDRFSVLNSQHMFEVLAAMNHRSLILLDECSKVVLDNIHGCPLRIMINILQSCKDLQYHNLDLFKGLADYVAATFDIWKFRKVLFILILFENLGFRPVGLMDLFMKRIVEDPESLNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTGYLHTISSENLLDAVYSFCLMNYFPLAPFNQLLQKDIISELLTSDDMKNAYKLHTLDTCLKLDDTVYLRDIALSLPQLPRELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMDTNRNQVLPLSDVDTTSATDIQRVAVLCVSRSAYCLGSSHPRGFLAMKMRHLNAMGFHVILVNNWEMDKLEMEDAVTFLKTKIYSVEALPVAAVNVQSTQ", "length": 710 }, "evidence": [ { "id": "F1N1T6", "url": "https://omabrowser.org/oma/group/F1N1T6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "mitochondrial RNA processing", "id": "GO:0000963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000963", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "mitochondrial large ribosomal subunit assembly", "id": "GO:1902775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902775", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "regulation of mitochondrial mRNA stability", "id": "GO:0044528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044528", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "mitochondrial RNA modification", "id": "GO:1900864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900864", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "F1N1T6", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1T6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 688, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1T6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1T6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1T6" }, { "id": "PS51286", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RAP", "eco_id": "ECO_0000259", "start_pos": 612, "end_pos": 669, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 591, "end_pos": 593 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1U5-1", "uniprot_ac": "F1N1U5", "uniprot_id": "F1N1U5_BOVIN", "mass": { "chemical_mass": 25029.0, "monoisotopic_mass": 25029.0 }, "refseq": { "ac": "NP_001179532", "name": "protein FEV", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179532" }, "gene_names": [ { "name": "FEV", "type": "recommended", "evidence": [ { "id": "F1N1U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ] }, { "name": "FEV", "type": "synonym", "evidence": [ { "id": "NP_001179532", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179532" } ] } ], "protein_names": [ { "name": "Protein FEV", "type": "recommended", "evidence": [ { "id": "F1N1U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1U5/entry#names_and_taxonomy" } ] }, { "name": "FEV, ETS transcription factor", "type": "synonym", "evidence": [ { "id": "NP_001179532", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179532" } ] }, { "name": "PC12 ETS domain-containing transcription factor 1", "type": "synonym", "evidence": [ { "id": "F1N1U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1U5/entry#names_and_taxonomy" } ] }, { "name": "protein FEV", "type": "synonym", "evidence": [ { "id": "NP_001179532", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179532" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FEV", "url": "https://www.uniprot.org/uniprotkb/F1N1U5", "locus": { "chromosome": "2", "start_pos": 106924889, "end_pos": 106929508, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020191", "url": "https://www.ensembl.org/id/ENSBTAG00000020191" } ] } } ], "crossref": [ { "id": "F1N1U5", "url": "https://alphafold.ebi.ac.uk/entry/F1N1U5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020191", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020191", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524933", "url": "https://www.ncbi.nlm.nih.gov/gene/524933", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524933", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524933", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GFSYWAG", "url": "https://omabrowser.org/oma/group/GFSYWAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1U5", "url": "https://www.orthodb.org/?gene=F1N1U5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF203", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF203", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179532", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1U5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1U5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRQSGASQPLLINMYLPDPVGDGLFKEGKSPGWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAATAALYPSPGLQPPPGPFGAVAAASHLGGHYH", "length": 239, "header": "tr|F1N1U5-1|F1N1U5_BOVIN Isoform 1 of Protein FEV OS=Bos taurus OX=9913 GN=FEV PE=3 SV=2 CANONICAL=F1N1U5-1" }, "isoforms": [ { "isoform_ac": "F1N1U5-1", "url": "https://www.uniprot.org/uniprotkb/F1N1U5/entry", "sequence": { "sequence": "MRQSGASQPLLINMYLPDPVGDGLFKEGKSPGWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAATAALYPSPGLQPPPGPFGAVAAASHLGGHYH", "length": 239, "header": "tr|F1N1U5-1|F1N1U5_BOVIN Isoform 1 of Protein FEV OS=Bos taurus OX=9913 GN=FEV PE=3 SV=2 CANONICAL=F1N1U5-1" }, "locus": { "chromosome": "2", "start_pos": 106928790, "end_pos": 106925088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026892.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026892.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026892.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026892.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524933", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524933", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B4A1-1", "protein_name": "Protein FEV", "gene_name": "FEV", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRQSGASQPLLINMYLPDPVGDGLFKEGKSPGWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAATAALYPSPGLQAPPGPFGAVAATSHLGGHYH", "length": 237 }, "evidence": [ { "id": "F1N1U5", "url": "https://omabrowser.org/oma/group/F1N1U5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A3FEM2-1", "protein_name": "Protein FEV", "gene_name": "fev", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKAYPFTSTTATTMRQNCGGSLMFNMYLSDPTENLLKESKSPSWTPINTGVQKGSGQIQLWQFLLELLSDSANMTCIAWEGTNGEFKLIDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFNGLAQVCQPSSTEQAIYKFQSNFAPIQFSGISKLNLVAPGVGPSGFSYWPGSPPTLYHSHNLQPPGPFGAVSASHLSCVNNINSLNNLNNINNHYN", "length": 235 }, "evidence": [ { "id": "F1N1U5", "url": "https://omabrowser.org/oma/group/F1N1U5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O70132-1", "protein_name": "Protein FEV", "gene_name": "Fev", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRQSGTSQPLLINMYLPDPVGDGLFKEGKSPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQPPPGPFGAVAAASHLGGHYH", "length": 237 }, "evidence": [ { "id": "F1N1U5", "url": "https://omabrowser.org/oma/group/F1N1U5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8QZW2-1", "protein_name": "Protein FEV", "gene_name": "Fev", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRQSGTSQPLLINMYLPDPVGDGLFKEGKSPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQPPPGPFGAVAAASHLGGHYH", "length": 237 }, "evidence": [ { "id": "F1N1U5", "url": "https://omabrowser.org/oma/group/F1N1U5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99581-1", "protein_name": "Protein FEV", "gene_name": "FEV", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRQSGASQPLLINMYLPDPVGDGLFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPPPGPFGAVAAASHLGGHYH", "length": 238 }, "evidence": [ { "id": "F1N1U5", "url": "https://omabrowser.org/oma/group/F1N1U5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "F1N1U5", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1U5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 239, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1U5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1U5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1U5" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 127, "start_aa": "Ile", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1X8-1", "uniprot_ac": "F1N1X8", "uniprot_id": "F1N1X8_BOVIN", "mass": { "chemical_mass": 47581.0, "monoisotopic_mass": 47581.0 }, "refseq": {}, "gene_names": [ { "name": "UBE2Z", "type": "recommended", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ], "protein_names": [ { "name": "Ubiquitin-conjugating enzyme E2 Z", "type": "recommended", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.23", "type": "synonym", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry#names_and_taxonomy" } ] }, { "name": "E2 ubiquitin-conjugating enzyme Z", "type": "synonym", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry#names_and_taxonomy" } ] }, { "name": "Uba6-specific E2 conjugating enzyme 1", "type": "synonym", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin carrier protein Z", "type": "synonym", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin-protein ligase Z", "type": "synonym", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE2Z", "url": "https://www.uniprot.org/uniprotkb/F1N1X8", "locus": { "chromosome": "19", "start_pos": 37596244, "end_pos": 37611943, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018802", "url": "https://www.ensembl.org/id/ENSBTAG00000018802" } ] } } ], "crossref": [ { "id": "F1N1X8", "url": "https://alphafold.ebi.ac.uk/entry/F1N1X8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018802", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018802", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23809", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23809", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KHQQENP", "url": "https://omabrowser.org/oma/group/KHQQENP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1X8", "url": "https://www.orthodb.org/?gene=F1N1X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46116:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46116:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8866652", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866652", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1X8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAGPVHTLAWRAQTPTLSGGLWVDALAERFSLLWEGRGGASAARAREARVGTLCPRSRWCRSGREQRPLWSADVLPSSPGSEGAMAESPTEEAATATAGAGAAGPGASGVTGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENTEMDSDSSSSGTETDLHGSLRV", "length": 441, "header": "tr|F1N1X8-1|F1N1X8_BOVIN Isoform 1 of Ubiquitin-conjugating enzyme E2 Z OS=Bos taurus OX=9913 GN=UBE2Z PE=4 SV=2 CANONICAL=F1N1X8-1" }, "isoforms": [ { "isoform_ac": "F1N1X8-1", "url": "https://www.uniprot.org/uniprotkb/F1N1X8/entry", "sequence": { "sequence": "MRAGPVHTLAWRAQTPTLSGGLWVDALAERFSLLWEGRGGASAARAREARVGTLCPRSRWCRSGREQRPLWSADVLPSSPGSEGAMAESPTEEAATATAGAGAAGPGASGVTGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENTEMDSDSSSSGTETDLHGSLRV", "length": 441, "header": "tr|F1N1X8-1|F1N1X8_BOVIN Isoform 1 of Ubiquitin-conjugating enzyme E2 Z OS=Bos taurus OX=9913 GN=UBE2Z PE=4 SV=2 CANONICAL=F1N1X8-1" }, "locus": { "chromosome": "19", "start_pos": 37611744, "end_pos": 37598214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043423.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043423.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040996.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040996.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-8866652", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866652", "resource": "Reactome", "description": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LSU8-1", "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "UBE2Z", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAESPTEEAATATAGAGAAGPGASGVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV", "length": 356 }, "evidence": [ { "id": "F1N1X8", "url": "https://omabrowser.org/oma/group/F1N1X8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3B7D1-1", "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "Ube2z", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAESPTEEAATATAGAGAAGPGASGVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV", "length": 356 }, "evidence": [ { "id": "F1N1X8", "url": "https://omabrowser.org/oma/group/F1N1X8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UE37-1", "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "Ube2z", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAESPTEEAATATAGAGAAGPGSSGVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV", "length": 356 }, "evidence": [ { "id": "F1N1X8", "url": "https://omabrowser.org/oma/group/F1N1X8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H832-1", "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "UBE2Z", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESPTEEAATAGAGAAGPGASSVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV", "length": 354 }, "evidence": [ { "id": "F1N1X8", "url": "https://omabrowser.org/oma/group/F1N1X8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1N1X8", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHP1-1", "Q17QG5-1", "Q1RMX2-1", "Q2T9X7-1", "Q2TA10-1", "Q1RML1-1", "F1N1X8-1", "F1ME38-1" ], "evidence": [ { "id": "R-BTA-8852127", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852127" } ] }, { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A3KMV5-1", "A3KN22-1", "A6H795-1", "Q32PA5-1", "Q3MHP1-1", "A5PJC4-1", "Q0P5K3-1", "Q17QG5-1", "Q1RMW1-1", "Q1RMX2-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32P99-1", "Q1RML1-1", "A0A3Q1MLB6-1", "F1N1X8-1", "F1N3I3-1", "F1ME38-1", "A0A3Q1MAR8-1", "Q32L27-1", "A0ABI0NWC8-1" ], "evidence": [ { "id": "R-BTA-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983152" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KMV5", "gene_name": "UBA1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A3KMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV5" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A3KMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV5" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1ME38", "gene_name": "UBA6", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1X8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1X8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1X8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 340, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.23", "ec_name": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "2.3.2.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.23" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1Y7-1", "uniprot_ac": "F1N1Y7", "uniprot_id": "F1N1Y7_BOVIN", "mass": { "chemical_mass": 47832.0, "monoisotopic_mass": 47832.0 }, "refseq": {}, "gene_names": [ { "name": "NPFFR1", "type": "recommended", "evidence": [ { "id": "F1N1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ] } ], "protein_names": [ { "name": "Neuropeptide FF receptor 1", "type": "recommended", "evidence": [ { "id": "F1N1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 147", "type": "synonym", "evidence": [ { "id": "F1N1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7/entry#names_and_taxonomy" } ] }, { "name": "RFamide-related peptide receptor OT7T022", "type": "synonym", "evidence": [ { "id": "F1N1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7#function" }, { "database": "UniProtKB", "id": "ARBA00025478", "url": "https://www.uniprot.org/uniprotkb/ARBA00025478#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPFFR1", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7", "locus": { "chromosome": "28", "start_pos": 26468932, "end_pos": 26489561, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010930", "url": "https://www.ensembl.org/id/ENSBTAG00000010930" } ] } } ], "crossref": [ { "id": "F1N1Y7", "url": "https://alphafold.ebi.ac.uk/entry/F1N1Y7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010930", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010930", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1Y7", "url": "https://www.orthodb.org/?gene=F1N1Y7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24241:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24241:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-389397", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389397", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGEPAQPSNSSWPPSENGSDAQATPAANLTFSSYYQHSSPVAAMFIVAYVLIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAISDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAITLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRKVYTAVLFSHIYLAPLALIVVMYARIARKLCQAPGPACAGGEEAAGEGGRGARRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSEPQLHLVTAYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRAQLCAPPWGSHREAYSQRASRLLRTRVFVEVQPSDSGLPSESGPSSGAPRPGRLPLRSGRVAHHSLAAEGPGCSHLPLTIPAWDI", "length": 433, "header": "tr|F1N1Y7-1|F1N1Y7_BOVIN Isoform 1 of Neuropeptide FF receptor 1 OS=Bos taurus OX=9913 GN=NPFFR1 PE=3 SV=4 CANONICAL=F1N1Y7-1" }, "isoforms": [ { "isoform_ac": "F1N1Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7/entry", "sequence": { "sequence": "MDGEPAQPSNSSWPPSENGSDAQATPAANLTFSSYYQHSSPVAAMFIVAYVLIFLLCMVGNTLVCFIVLKNRHMRTVTNMFILNLAISDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAITLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRKVYTAVLFSHIYLAPLALIVVMYARIARKLCQAPGPACAGGEEAAGEGGRGARRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSEPQLHLVTAYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRAQLCAPPWGSHREAYSQRASRLLRTRVFVEVQPSDSGLPSESGPSSGAPRPGRLPLRSGRVAHHSLAAEGPGCSHLPLTIPAWDI", "length": 433, "header": "tr|F1N1Y7-1|F1N1Y7_BOVIN Isoform 1 of Neuropeptide FF receptor 1 OS=Bos taurus OX=9913 GN=NPFFR1 PE=3 SV=4 CANONICAL=F1N1Y7-1" }, "locus": { "chromosome": "28", "start_pos": 26489561, "end_pos": 26468935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014519.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014519.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014519.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014519.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-389397", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389397", "resource": "Reactome", "description": "Orexin and neuropeptides FF and QRFP bind to their respective receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "pmid": "" }, { "name": "neuropeptide receptor activity", "id": "GO:0008188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008188", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "pmid": "" }, { "name": "9+0 non-motile cilium", "id": "GO:0097731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097731", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "pmid": "" }, { "name": "cellular response to hormone stimulus", "id": "GO:0032870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032870", "evidence": [ { "database": "UniProtKB", "id": "F1N1Y7", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1Y7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 433, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1Y7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1Y7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Y7" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 60, "end_pos": 332, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 113, "end_pos": 115 }, { "start_pos": 18, "end_pos": 20 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 324, "end_pos": 326 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N1Z0-1", "uniprot_ac": "F1N1Z0", "uniprot_id": "F1N1Z0_BOVIN", "mass": { "chemical_mass": 26671.0, "monoisotopic_mass": 26671.0 }, "refseq": {}, "gene_names": [ { "name": "VTI1B", "type": "recommended", "evidence": [ { "id": "F1N1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ] } ], "protein_names": [ { "name": "Vesicle transport through interaction with t-SNAREs homolog 1B", "type": "recommended", "evidence": [ { "id": "F1N1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VTI1B", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0", "locus": { "chromosome": "10", "start_pos": 79534831, "end_pos": 79553093, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001948", "url": "https://www.ensembl.org/id/ENSBTAG00000001948" } ] } } ], "crossref": [ { "id": "F1N1Z0", "url": "https://alphafold.ebi.ac.uk/entry/F1N1Z0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001948", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001948", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15890", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15890", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1Z0", "url": "https://www.orthodb.org/?gene=F1N1Z0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21230", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21230", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21230:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21230:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Z0-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSAASSEHFEKLHEIFRGLHEDLRGVPERLLGMAGTGEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRTYRKDLAKLHREVRSTPLTATPGARGDMKYGTYAVENEHMNRLQSQRALLLQGTDSLNRATQSIERSHRIAAETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIVILLELAILGGLVYYKFFRRH", "length": 232, "header": "tr|F1N1Z0-1|F1N1Z0_BOVIN Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1B OS=Bos taurus OX=9913 GN=VTI1B PE=3 SV=2 CANONICAL=F1N1Z0-1" }, "isoforms": [ { "isoform_ac": "F1N1Z0-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0/entry", "sequence": { "sequence": "MATSAASSEHFEKLHEIFRGLHEDLRGVPERLLGMAGTGEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRTYRKDLAKLHREVRSTPLTATPGARGDMKYGTYAVENEHMNRLQSQRALLLQGTDSLNRATQSIERSHRIAAETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIVILLELAILGGLVYYKFFRRH", "length": 232, "header": "tr|F1N1Z0-1|F1N1Z0_BOVIN Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1B OS=Bos taurus OX=9913 GN=VTI1B PE=3 SV=2 CANONICAL=F1N1Z0-1" }, "locus": { "chromosome": "10", "start_pos": 79552894, "end_pos": 79535065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002532.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002532.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002532.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002532.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 103, "start_aa": "Thr", "end_pos": 103, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr103", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chloride channel inhibitor activity", "id": "GO:0019869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019869", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" }, { "name": "regulation of protein localization to plasma membrane", "id": "GO:1903076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903076", "evidence": [ { "database": "UniProtKB", "id": "F1N1Z0", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N1Z0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 232, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N1Z0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N1Z0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Z0" }, { "id": "SM00397", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00397" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "T-SNARE coiled-coil homology", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 198, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 103 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N201-1", "uniprot_ac": "F1N201", "uniprot_id": "F1N201_BOVIN", "mass": { "chemical_mass": 35068.0, "monoisotopic_mass": 35068.0 }, "refseq": { "ac": "XP_002688835", "name": "olfactory receptor 7G1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688835" }, "gene_names": [ { "name": "OR7G8", "type": "recommended", "evidence": [ { "id": "F1N201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N201" } ] }, { "name": "OR7G8", "type": "synonym", "evidence": [ { "id": "XP_002688835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688835" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N201/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 7G1", "type": "synonym", "evidence": [ { "id": "XP_002688835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688835" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7G8", "url": "https://www.uniprot.org/uniprotkb/F1N201", "locus": { "chromosome": "7", "start_pos": 13459477, "end_pos": 13460415, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023623", "url": "https://www.ensembl.org/id/ENSBTAG00000023623" } ] } } ], "crossref": [ { "id": "F1N201", "url": "https://alphafold.ebi.ac.uk/entry/F1N201", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023623", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023623", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511678", "url": "https://www.ncbi.nlm.nih.gov/gene/511678", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511678", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511678", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YLVIMEP", "url": "https://omabrowser.org/oma/group/YLVIMEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N201", "url": "https://www.orthodb.org/?gene=F1N201", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688835", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688835", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N201-1", "url": "https://www.uniprot.org/uniprotkb/F1N201-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPRNKTGILEFLLMEVTEDPELQPLHFILFLFIYLVTILGNLLIIMAVISDSHLHTPMYFFLYNLSFTDICLSTTTIPKMLVNIQTQNQSITYTGCLTQLCFILVFVGLENSLLAVMAYDRYVAICHPLRYMAIMNFPLCGQLILFSLFISIVDALLHSLMVLQLTFCTDLEIPLFFCEVVQVIKLACSDTLINNILIYLATSIFGGIPVCGIIFSYIQIVSSVLRMPSASGKYKAFSTCGSHLSVVSLFYGTGFGVYISSALTNSSRNTAVLSMMYTVVPQMMNPFIYSLRNRDMKRALRKLIVRTSSFL", "length": 312, "header": "tr|F1N201-1|F1N201_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR7G8 PE=3 SV=2 CANONICAL=F1N201-1" }, "isoforms": [ { "isoform_ac": "F1N201-1", "url": "https://www.uniprot.org/uniprotkb/F1N201/entry", "sequence": { "sequence": "MGPRNKTGILEFLLMEVTEDPELQPLHFILFLFIYLVTILGNLLIIMAVISDSHLHTPMYFFLYNLSFTDICLSTTTIPKMLVNIQTQNQSITYTGCLTQLCFILVFVGLENSLLAVMAYDRYVAICHPLRYMAIMNFPLCGQLILFSLFISIVDALLHSLMVLQLTFCTDLEIPLFFCEVVQVIKLACSDTLINNILIYLATSIFGGIPVCGIIFSYIQIVSSVLRMPSASGKYKAFSTCGSHLSVVSLFYGTGFGVYISSALTNSSRNTAVLSMMYTVVPQMMNPFIYSLRNRDMKRALRKLIVRTSSFL", "length": 312, "header": "tr|F1N201-1|F1N201_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR7G8 PE=3 SV=2 CANONICAL=F1N201-1" }, "locus": { "chromosome": "7", "start_pos": 13460415, "end_pos": 13459480, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002518.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002518.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002518.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002518.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511678", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511678", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K469-1", "protein_name": "Olfactory receptor", "gene_name": "Or7g34", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFHPLYQIYEQHEKRNQTAFPGFFLLGLTEDPKLQPVLVSLFFSIYLVTLLGNLLIIVISISDSHLHTPMYIFLSNLSLNDICLSTSTIPKMLVNIQENIQSITYKGCLTQMSFVLIFSGMENCLLAVMAYDRYMAICHPLRYTVIMEPCFCVLLILLSLLISLVDSLMHSLMVLRLSFCRHLEIPNFFCELPKMLKLACSDTLIDNILIYISSCIFAGIPLSGIVFSYIHIMSSIFRMPSSEGKHKAFTTCGSHLSVVSLFYGTGFGVYITSIIMDSSRKTAVASVMYSVVPQMLNPFIYSLRNREMKDAMRKFFKKMAYFL", "length": 323 }, "evidence": [ { "id": "F1N201", "url": "https://omabrowser.org/oma/group/F1N201/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VFF2-1", "protein_name": "Olfactory receptor", "gene_name": "Or7g31", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNNMEKRNQTTFPGFLLLGLTEDPKLQPVFVSLFFSIYLITILGNLLIILISISDAHLHTPMYLFLSNLSLNDICLSTSTIPKMLVNIKENSQSITYKGCLTQMSFVLIFCGMENCLLAVMAYDRYIAICHPLRYTVIMEPCFCVLLILLSLLISVVDTLMHSLMVLRLSFCTHLEISNFICELPQILKLACSDTLIDNILIYLSACIFTGIPISGIVFSYVHIISSILRMSSLEGKHKAFTTCGSHLSVVSLFYGTAFGVYITSIIMDSSRNTAVASVMYSVVPQMLNPFIYSLRNRDMKEAMGKFFSRMASFL", "length": 315 }, "evidence": [ { "id": "F1N201", "url": "https://omabrowser.org/oma/group/F1N201/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N201", "url": "https://www.uniprot.org/uniprotkb/F1N201" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N201-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N201-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N201" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N201" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N207-1", "uniprot_ac": "F1N207", "uniprot_id": "F1N207_BOVIN", "mass": { "chemical_mass": 84458.0, "monoisotopic_mass": 84458.0 }, "refseq": {}, "gene_names": [ { "name": "SLC26A3", "type": "recommended", "evidence": [ { "id": "F1N207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ] } ], "protein_names": [ { "name": "Solute carrier family 26 member 3", "type": "synonym", "evidence": [ { "id": "F1N207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N207/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC26A3", "url": "https://www.uniprot.org/uniprotkb/F1N207", "locus": { "chromosome": "4", "start_pos": 48780316, "end_pos": 48813887, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015547", "url": "https://www.ensembl.org/id/ENSBTAG00000015547" } ] } } ], "crossref": [ { "id": "F1N207", "url": "https://alphafold.ebi.ac.uk/entry/F1N207", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WVMTFIF", "url": "https://omabrowser.org/oma/group/WVMTFIF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N207", "url": "https://www.orthodb.org/?gene=F1N207", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01740", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01740", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-427601", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-427601", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N207-1", "url": "https://www.uniprot.org/uniprotkb/F1N207-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEPIGNQYVVARPVYSANAFGEDHKKKQRHHKTLLDHLKKLCRCSAQRAKKIAFSSFPIASWLPAYRIKEWLLSDIVSGISTGLVAVLQGLAFALLVTIPPGYGLYAAFFPVIIYFFLGTSRHISVGPFPVLSMMVGAVVVRLTPTDSAADSTFANSSMTNDSSIDEQKVIVAATVTILSGIIQLLMGVLRLGFVVIYLSESLISGFTTAAAIHVLVSQLKFMFQLTVPAHTDPFSLFKVLESVFSQIEKTNIADLVTSLVILVVVFVVKEINQRYKAKLPVPIPIELIVTVIATGVSYGFDFKRRFNVAVIGEMKPGFQAPIIPSRQTFQDTIGDCFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIAMGAGNIFGGSFRGFAASTSLSRSGVQESTGGKTQIAGLISAIIVLIVIVAIGFLLEPLQKSVLAALALGNLKGMLMQFVEIRRLWRKDKYDCLIWVMTFIFAVVLGLGLGLAASVAFQLLTIVFRTQFPKCSMLANVGRSNIYKNRKDYSEIYEPEGVKIFRCPSPIYFANISFFKQKLIDAIGFRPLRILRKRNKALKKIRKLQKKGLLQVTPKGFICTVDGFKDSDEELDNDKIEELDQPINTKDLPFQIDWNANLPLNIVVPKINLHSLILDFSAVSFLDVSSMRGLKTILQEFIRIQVDVYIVGTDDDFIEKLKRCEFFDDEVKDSIFFLTIHDAVLHILMKKDYSTSKFNPSQEVEAKLDDFTINTNGGLRNRECQVPIETKF", "length": 760, "header": "tr|F1N207-1|F1N207_BOVIN Isoform 1 of Solute carrier family 26 member 3 OS=Bos taurus OX=9913 GN=SLC26A3 PE=4 SV=1 CANONICAL=F1N207-1" }, "isoforms": [ { "isoform_ac": "F1N207-1", "url": "https://www.uniprot.org/uniprotkb/F1N207/entry", "sequence": { "sequence": "MIEPIGNQYVVARPVYSANAFGEDHKKKQRHHKTLLDHLKKLCRCSAQRAKKIAFSSFPIASWLPAYRIKEWLLSDIVSGISTGLVAVLQGLAFALLVTIPPGYGLYAAFFPVIIYFFLGTSRHISVGPFPVLSMMVGAVVVRLTPTDSAADSTFANSSMTNDSSIDEQKVIVAATVTILSGIIQLLMGVLRLGFVVIYLSESLISGFTTAAAIHVLVSQLKFMFQLTVPAHTDPFSLFKVLESVFSQIEKTNIADLVTSLVILVVVFVVKEINQRYKAKLPVPIPIELIVTVIATGVSYGFDFKRRFNVAVIGEMKPGFQAPIIPSRQTFQDTIGDCFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIAMGAGNIFGGSFRGFAASTSLSRSGVQESTGGKTQIAGLISAIIVLIVIVAIGFLLEPLQKSVLAALALGNLKGMLMQFVEIRRLWRKDKYDCLIWVMTFIFAVVLGLGLGLAASVAFQLLTIVFRTQFPKCSMLANVGRSNIYKNRKDYSEIYEPEGVKIFRCPSPIYFANISFFKQKLIDAIGFRPLRILRKRNKALKKIRKLQKKGLLQVTPKGFICTVDGFKDSDEELDNDKIEELDQPINTKDLPFQIDWNANLPLNIVVPKINLHSLILDFSAVSFLDVSSMRGLKTILQEFIRIQVDVYIVGTDDDFIEKLKRCEFFDDEVKDSIFFLTIHDAVLHILMKKDYSTSKFNPSQEVEAKLDDFTINTNGGLRNRECQVPIETKF", "length": 760, "header": "tr|F1N207-1|F1N207_BOVIN Isoform 1 of Solute carrier family 26 member 3 OS=Bos taurus OX=9913 GN=SLC26A3 PE=4 SV=1 CANONICAL=F1N207-1" }, "locus": { "chromosome": "4", "start_pos": 48806719, "end_pos": 48780884, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033777.3", "url": "https://www.ensembl.org/id/ENSBTAT00000033777.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033686.2", "url": "https://www.ensembl.org/id/ENSBTAP00000033686.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-427601", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-427601", "resource": "Reactome", "description": "Inorganic anion exchange by SLC26 transporters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M917-1", "protein_name": "Chloride anion exchanger", "gene_name": "Slc26a3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIEAIGNQYIVARPVYSTNTFGEEFKKTHRHHKTFLDHLKGCCSCSSQRAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVASGGDSAPELSSSSIENDSVIEERVMVAASVTVLSGIIQLLLGVLQIGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLTVPAHSDPFSIFKVLESVFTQIHKTNIADLVTSVIILVVVFVVKEVNQRYRSKLPVPIPIELIMTVIATGISYGCNFEQRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYADVYEPEGVKIFRCPSPIYFANIGFFKQKLTDAVGFSPLRILRKRNKALKKIRKLQKRGLIQVTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFELDWNADLPLNITVPKISLHSLILDFSAVSFLDISSMRGLKTILQEFIRIKVDVYIVGTDDEFIDKLTRCEFFDDEVTDSIFFLTIHDAVLHILMKKDYSTSKFNSSQEKEMKFDFTINTNGGLRNRECQVPVETKF", "length": 757 }, "evidence": [ { "id": "F1N207", "url": "https://omabrowser.org/oma/group/F1N207/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Y9S9-1", "protein_name": "Solute carrier family 26 member 3", "gene_name": "SLC26A3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVEPVGNHYVVARRVYSENSFDEEYEKLHRYHKNFWDHLKLYFRCSPQRIKKVSLRMFPVVSWLPAYRFREWILSDIVSGINTGLVSVLQGLAFALLVNVPPGYGLYAAFFPVLVYFIFGTSRHISVGPFPVLSLMVGGVVTRLVPDGAAGNGTAVNMSAIDEQRVMVAASVTFLSGIFQLLLGLLQFGFIVIYLSHSLISGFTTAAAIHVLVSQIKFMLQLPVPGFNKPFGIIYTLESVFSQITDTNIADLVTSLLVLLIVFVVKEINERYKAKLPAPIPIELIVTVLAALISHFAKFEEKFKVAVVGKLEEGFQAPVAPDAGIIQNCVGDGISIAIVGFAVGFSVAKVYSIKHDYPIDGNQELIAFGLGNILGGSFKGFASSTALSRSGVQESTGGKTQIAGIVSAIIVLIVILAIGFLLAPLQKSVLASLALGNLKGMLMQFREVGVLWRKDKYDCMIWVVTFLAAVFLGLDIGLATAVAFELLTVVIRSQIPSCTTLANVGRSNIYRNRKDYNDIYEPEGVKIFKCSSPIFFANIEFFKEKLISAVGFSPLRVLRKRNKALRKIRKMLKKGELQVTPKGLICMAHHTQESDDELDNNRMEELDQPTDMADLPIQINWDAELPPGIVVPRVDIHSIVLDFSAVSFLDFSAMRVLQKTLKEFVRIDIDIYIAGAHEGFLEKLERCAFFDEEIKPSMFFLTIHDAVLHILLKKDIASSPKLKLAEKGSSNNYVITTSNGQRSWESTIPAETKF", "length": 754 }, "evidence": [ { "id": "F1N207", "url": "https://omabrowser.org/oma/group/F1N207/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P40879-1", "protein_name": "Chloride anion exchanger", "gene_name": "SLC26A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINTNGGLRNRVYEVPVETKF", "length": 764 }, "evidence": [ { "id": "F1N207", "url": "https://omabrowser.org/oma/group/F1N207/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q924C9-1", "protein_name": "Chloride anion exchanger", "gene_name": "Slc26a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIEAIGNQYVVARPVYSTKAFGEEFKKTYGHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVASGSDTSPALSSSSAENDSMIEEKVMVAASVTVLSGIIQLLLGVLQIGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLTVPAHSDPFSIFKVLESVFSQIQKTNIADLVTSVIILVVVFVVKEINQRYRSKLPVPIPIELIMTVIATGISYGCNFEQRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDCFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYADVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFNPLRILRKRNKALKKIRKLQKQGLIQVTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFEIDWNADLPLNITIPKISLHSLILDFSAVSFLDISSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHIWMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF", "length": 757 }, "evidence": [ { "id": "F1N207", "url": "https://omabrowser.org/oma/group/F1N207/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9WVC8-1", "protein_name": "Chloride anion exchanger", "gene_name": "Slc26a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVLESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGCNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF", "length": 757 }, "evidence": [ { "id": "F1N207", "url": "https://omabrowser.org/oma/group/F1N207/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "membrane hyperpolarization", "id": "GO:0060081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060081", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "sulfate transmembrane transport", "id": "GO:1902358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902358", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "intracellular pH elevation", "id": "GO:0051454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051454", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "oxalate transmembrane transporter activity", "id": "GO:0019531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019531", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "secondary active sulfate transmembrane transporter activity", "id": "GO:0008271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008271", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "sulfate transmembrane transporter activity", "id": "GO:0015116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015116", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" }, { "name": "chloride:bicarbonate antiporter activity", "id": "GO:0140900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140900", "evidence": [ { "database": "UniProtKB", "id": "F1N207", "url": "https://www.uniprot.org/uniprotkb/F1N207" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N207-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 760, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N207-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N207" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N207" }, { "id": "PS50801", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50801" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "STAS", "eco_id": "ECO_0000259", "start_pos": 520, "end_pos": 715, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 543, "end_pos": 545 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N209-1", "uniprot_ac": "F1N209", "uniprot_id": "F1N209_BOVIN", "mass": { "chemical_mass": 28164.0, "monoisotopic_mass": 28164.0 }, "refseq": {}, "gene_names": [ { "name": "RBM11", "type": "recommended", "evidence": [ { "id": "F1N209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ] } ], "protein_names": [ { "name": "Splicing regulator RBM11", "type": "recommended", "evidence": [ { "id": "F1N209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N209/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 11", "type": "synonym", "evidence": [ { "id": "F1N209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N209/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209#function" }, { "database": "UniProtKB", "id": "ARBA00059611", "url": "https://www.uniprot.org/uniprotkb/ARBA00059611#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM11", "url": "https://www.uniprot.org/uniprotkb/F1N209", "locus": { "chromosome": "1", "start_pos": 22948046, "end_pos": 22966987, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034347", "url": "https://www.ensembl.org/id/ENSBTAG00000034347" } ] } } ], "crossref": [ { "id": "F1N209", "url": "https://alphafold.ebi.ac.uk/entry/F1N209", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034347", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034347", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N209", "url": "https://www.orthodb.org/?gene=F1N209", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13798", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13798", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13798:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13798:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N209-1", "url": "https://www.uniprot.org/uniprotkb/F1N209-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPAQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTICKDREGKPKSFGFVCFKHPESVSYAIALLNGIRLYGRPINVQYRFGSSRSCEPANQSFESCVKINSHSYRNEEAMGRSSFSMQFSPINNASLSQEYFLFQKMVNMCGFFPQQWPTYYPALQLPYYEMTAPLPNSTSASSSLNHVSDLEAGPSSYEWTQQQPSDSDLYQTNKRKRQKQSSDSDSSTENSRGNEYSPKFQKCKKKRY", "length": 246, "header": "tr|F1N209-1|F1N209_BOVIN Isoform 1 of Splicing regulator RBM11 OS=Bos taurus OX=9913 GN=RBM11 PE=4 SV=4 CANONICAL=F1N209-1" }, "isoforms": [ { "isoform_ac": "F1N209-1", "url": "https://www.uniprot.org/uniprotkb/F1N209/entry", "sequence": { "sequence": "MLPAQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTICKDREGKPKSFGFVCFKHPESVSYAIALLNGIRLYGRPINVQYRFGSSRSCEPANQSFESCVKINSHSYRNEEAMGRSSFSMQFSPINNASLSQEYFLFQKMVNMCGFFPQQWPTYYPALQLPYYEMTAPLPNSTSASSSLNHVSDLEAGPSSYEWTQQQPSDSDLYQTNKRKRQKQSSDSDSSTENSRGNEYSPKFQKCKKKRY", "length": 246, "header": "tr|F1N209-1|F1N209_BOVIN Isoform 1 of Splicing regulator RBM11 OS=Bos taurus OX=9913 GN=RBM11 PE=4 SV=4 CANONICAL=F1N209-1" }, "locus": { "chromosome": "1", "start_pos": 22966805, "end_pos": 22949281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048660.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048660.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045656.6", "url": "https://www.ensembl.org/id/ENSBTAP00000045656.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "pmid": "" }, { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "F1N209", "url": "https://www.uniprot.org/uniprotkb/F1N209" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N209-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N209-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N209" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N209" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 87, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N230-1", "uniprot_ac": "F1N230", "uniprot_id": "F1N230_BOVIN", "mass": { "chemical_mass": 67954.0, "monoisotopic_mass": 67954.0 }, "refseq": {}, "gene_names": [ { "name": "ORC2", "type": "recommended", "evidence": [ { "id": "F1N230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ] } ], "protein_names": [ { "name": "Origin recognition complex subunit 2", "type": "recommended", "evidence": [ { "id": "F1N230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N230/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230#function" }, { "database": "UniProtKB", "id": "RU368084", "url": "https://www.uniprot.org/uniprotkb/RU368084#function" }, { "database": "UniProtKB", "id": "A0A3Q1LR25", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR25#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3R5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ORC2", "url": "https://www.uniprot.org/uniprotkb/F1N230", "locus": { "chromosome": "2", "start_pos": 89551970, "end_pos": 89589796, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031473", "url": "https://www.ensembl.org/id/ENSBTAG00000031473" } ] } } ], "crossref": [ { "id": "F1N230", "url": "https://alphafold.ebi.ac.uk/entry/F1N230", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031473", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031473", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AHERYFF", "url": "https://omabrowser.org/oma/group/AHERYFF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N230", "url": "https://www.orthodb.org/?gene=F1N230", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14052", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14052", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14052:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14052:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24882", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24882", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-176187", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68616", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68616", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68962", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LR25", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR25-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3R5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3R5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N230-1", "url": "https://www.uniprot.org/uniprotkb/F1N230-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSTLELKADKMLKVQFVGDDDVLNHILDREGGPKIKKERAQLLVNTQKIIKKPENELEEDDQEVLKDHNYVEVLGQDVQESLKNGSATDGGNKVYPFQNRKHPEKMAKLDLEGRLEDAWKTVSKASELAKTPRKSVSLNMKNDPKITIDIPQCSKGHSSSDKSQLKNNDKSEFLSTAPRGLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEYEEDTNEDILSQKIQAQNREVSAPVFRETPSKKMKREKTSHLVEKYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLHNLLSKVSPSFSAELKQLNQQHEQLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDCIHIVINGFFPGISVKSVLNSVTEVLDHVGTFRSVLDQLEWITNKFKEDSSLELFLLIHNLDSQMLRGDKSQQIIGQLSSLRNIYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSHYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLIKYQLDNQDNPSYTGLCFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGILTDFLENEEEEL", "length": 592, "header": "tr|F1N230-1|F1N230_BOVIN Isoform 1 of Origin recognition complex subunit 2 OS=Bos taurus OX=9913 GN=ORC2 PE=3 SV=3 CANONICAL=F1N230-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR25-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR25/entry", "sequence": { "sequence": "MTSTLELKADKMLKVQFVGDDDVLNHILDREGGPKIKKERAQLLVNTQKIIKKPENELEEDDQEVLKDHNYVEVLGQDVQESLKNGSATDGGNKVYPFQNRKHPEKMAKLASELAKTPRKSVSLNMKNDPKITIDIPQCSKGKILPQLFKESFQELLQIINNDKSEFLSTAPRGLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEYEEDTNEDILSQKIQAQNREVSAPVFRETPSKKMKREKTSHLVEKYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLHNLLSKVSPSFSAELKQLNQQHEQLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDCIHIVINGFFPGISVKSVLNSVTEVLDHVGTFRSVLDQLEWITNKFKEDSSLELFLLIHNLDSQMLRGDKSQQIIGQLSSLRNIYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSHYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLIKYQLDNQDNPSYTGLCFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGILTDFLENEEEEL", "length": 585, "header": "tr|A0A3Q1LR25-1|A0A3Q1LR25_BOVIN Computationally mapped isoform of Origin recognition complex subunit 2 OS=Bos taurus OX=9913 GN=ORC2 PE=3 SV=1 CANONICAL=F1N230-1" }, "locus": { "chromosome": "2", "start_pos": 89582138, "end_pos": 89553637, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079428.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079428.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059428.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059428.1" } ] } }, { "isoform_ac": "A0A3Q1M3R5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R5/entry", "sequence": { "sequence": "MTSTLELKADKMLKVQFVGDDDVLNHILDREGGPKIKKERAQLLVNTQKIIKKPENELEEDDQEVLKDHNYVEVLGQDVQESLKNGSATDGGNKVYPFQNRKHPEKMAKLASELAKTPRKSVSLNMKNDPKITIDIPQCSKGHSSSDKSQLKNNDKSEFLSTAPRGLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEYEEDTNEDILSQKIQAQNREVSAPVFRETPSKKMKREKTSHLVEKYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLHNLLSKVSPSFSAELKQLNQQHEQLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDCIHIVINGFFPGISVKSVLNSVTEVLDHVGTFRSVLDQLEWITNKFKEVWDHAKQSLYNWLWYETTTYSHYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLIKYQLDNQDNPSYTGLCFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGILTDFLENEEEEL", "length": 528, "header": "tr|A0A3Q1M3R5-1|A0A3Q1M3R5_BOVIN Computationally mapped isoform of Origin recognition complex subunit 2 OS=Bos taurus OX=9913 GN=ORC2 PE=3 SV=1 CANONICAL=F1N230-1" }, "locus": { "chromosome": "2", "start_pos": 89582138, "end_pos": 89553637, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071960.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071960.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062847.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062847.2" } ] } }, { "isoform_ac": "F1N230-1", "url": "https://www.uniprot.org/uniprotkb/F1N230/entry", "sequence": { "sequence": "MTSTLELKADKMLKVQFVGDDDVLNHILDREGGPKIKKERAQLLVNTQKIIKKPENELEEDDQEVLKDHNYVEVLGQDVQESLKNGSATDGGNKVYPFQNRKHPEKMAKLDLEGRLEDAWKTVSKASELAKTPRKSVSLNMKNDPKITIDIPQCSKGHSSSDKSQLKNNDKSEFLSTAPRGLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEYEEDTNEDILSQKIQAQNREVSAPVFRETPSKKMKREKTSHLVEKYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLHNLLSKVSPSFSAELKQLNQQHEQLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDCIHIVINGFFPGISVKSVLNSVTEVLDHVGTFRSVLDQLEWITNKFKEDSSLELFLLIHNLDSQMLRGDKSQQIIGQLSSLRNIYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSHYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLIKYQLDNQDNPSYTGLCFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGILTDFLENEEEEL", "length": 592, "header": "tr|F1N230-1|F1N230_BOVIN Isoform 1 of Origin recognition complex subunit 2 OS=Bos taurus OX=9913 GN=ORC2 PE=3 SV=3 CANONICAL=F1N230-1" }, "locus": { "chromosome": "2", "start_pos": 89582138, "end_pos": 89553637, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044591.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044591.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042074.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042074.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-176187", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "resource": "Reactome", "description": "Activation of ATR in response to replication stress" }, { "id": "R-BTA-68616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68616", "resource": "Reactome", "description": "Assembly of the ORC complex at the origin of replication" }, { "id": "R-BTA-68689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68689", "resource": "Reactome", "description": "CDC6 association with the ORC:origin complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-68962", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "resource": "Reactome", "description": "Activation of the pre-replicative complex" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13416-1", "protein_name": "Origin recognition complex subunit 2", "gene_name": "ORC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEEDDQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA", "length": 577 }, "evidence": [ { "id": "F1N230", "url": "https://omabrowser.org/oma/group/F1N230/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q24168-1", "protein_name": "Origin recognition complex subunit 2", "gene_name": "Orc2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSASNKGGYKTPRKENLMSIENLTNSEEESEDLNTAMVGNAVESQPKVTSRRSTRRPSPTKKYQAYQKESNGKGQEERIVVNYVEMSDERSSDAEDQEEEESIEESENAARPAAKDLHLIQSEYNVAGTSMFGFNTPKKRDAMALAALNATPCTPKTPKTPRLGVKTPDTKRKKSMDQPKTPAHVRTRVKKQIAKIVADSDEDFSGDESDFRPSDEESSSSSSSSDAGNSSDNDAADDEPKTPSRARRAIVVPVLPKTPSAARLRQSARAKKSNEFVPESDGYFHSHASSKILTSDHTLDRLKNPRLAADRVFSLLSEIKTSAEHEGSINAIMEEYRSYFPKWMCILNEGFNILLYGLGSKHQLLQSFHREVLHKQTVLVVNGFFPSLTIKDMLDSITSDILDAGISPANPHEAVDMIEEEFALIPETHLFLIVHNLDGAMLRNVKAQAILSRLARIPNIHLLASIDHINTPLLWDQGKLCSFNFSWWDCTTMLPYTNETAFENSLLVQNSGELALSSMRSVFSSLTTNSRGIYMLIVKYQLKNKGNATYQGMPFRDLYSSCREAFLVSSDLALRAQLTEFLDHKLVKSKRSVDGSEQLTIPIDGALLQQFLEEQEKK", "length": 618 }, "evidence": [ { "id": "F1N230", "url": "https://omabrowser.org/oma/group/F1N230/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q60862-1", "protein_name": "Origin recognition complex subunit 2", "gene_name": "Orc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTLQLKETKVPSVQFVGDDDVLSHILDREGGTKLKKEKAQLLVNPQKVIKKADCELEKSDLEVLEDQNYVKVLGRNIQESLGNGSAKDGRNKVYSFQQRKHPEEMTKLALELAKTSGKKDPLDSNDPEITKNIAQKSKGHSTSEKAPLVNNNKTEFLSTQPHNLRKRIIASRSHYDSESEYSASSSEDDEEATKDEEEDTNVARLSQKSQGQNRLLPAPVSKETLPKKKKRDKASDLVEEYFEAHSSSKVLTSDRTLQRLRRARVDQKTLHNLLRKFVPSFSAEIERLNQQHEKLFHKWMLQLHLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGYFPGVSVKSILNSITEDVLSHVGTFQSVLDQRDWIINRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLHNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKFQLDNQDSPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGILADFLEKEEEEA", "length": 576 }, "evidence": [ { "id": "F1N230", "url": "https://omabrowser.org/oma/group/F1N230/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q75PQ8-1", "protein_name": "Origin recognition complex subunit 2", "gene_name": "Orc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTLRLKEAKVPSVQFVGDDDVLSHILDREGGTKLKKEKVQLLVNPQKVIKKAECELEKSDLEVLEDQNYVEVLGRNIQESLGNGSAVDGRNKVYSFQHRKHPEEMTKLALELAKTSGKIDPLASNDPKITKNIARKSKGHSSEKAPLENNNKNEFPSIQPHNVRKRLIASRSHCDSESEYSASSSEDDEEVAKDDEEDTNVVRCSKKSQGQNRLLPAPVSKEILPKKRKRDKAGDLVEEYFEAHSSSKVLTSDRTLQKLRRARVDQKTLRNLLSKFVPSFSTEIGQLNQQHERLFDKWILQLRLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGFFPGISVKSILNSITEDVLSHMGTFQSVLDQRDWIMNRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLRNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKYQLDNQDCPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGTLADFLEKEEEEES", "length": 576 }, "evidence": [ { "id": "F1N230", "url": "https://omabrowser.org/oma/group/F1N230/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA replication origin binding", "id": "GO:0003688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003688", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "inner kinetochore", "id": "GO:0000939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000939", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" }, { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" }, { "name": "nuclear origin of replication recognition complex", "id": "GO:0005664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005664", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "F1N230", "url": "https://www.uniprot.org/uniprotkb/F1N230" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N230-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 592, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N230-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N230" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N230" }, { "id": "PF04084", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04084" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Origin recognition complex subunit 2 RecA-like", "eco_id": "ECO_0000259", "start_pos": 303, "end_pos": 462, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N230" }, { "id": "PF24882", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24882" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Origin recognition complex subunit 2 winged-helix", "eco_id": "ECO_0000259", "start_pos": 519, "end_pos": 578, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N263-1", "uniprot_ac": "F1N263", "uniprot_id": "F1N263_BOVIN", "mass": { "chemical_mass": 37073.0, "monoisotopic_mass": 37073.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Vomeronasal type-1 receptor", "type": "recommended", "evidence": [ { "id": "F1N263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N263/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1N263", "locus": {} } ], "crossref": [ { "id": "F1N263", "url": "https://alphafold.ebi.ac.uk/entry/F1N263", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017173", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017173", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13949", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13949", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112443506", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112443506", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DIQCKLV", "url": "https://omabrowser.org/oma/group/DIQCKLV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N263", "url": "https://www.orthodb.org/?gene=F1N263", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24062", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24062", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N263-1", "url": "https://www.uniprot.org/uniprotkb/F1N263-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SAHLLLFISPQVLTTCLFSSTKMNKNRLSSFIDIRNAFFSEVAIGILANTILLLFHAHNFLLEHRPKSTDLTIGHLALIHIVMLLTVAFMATDTFGSQKTWDDIQCKLVVHLYSSMRGLSICATCLLSVLRAITLSPRNSRLAKFKPHSSHHNLYCTLFLWVFNMFISGYFLVSTVATPSVTSAHLLHVTESCSLCPVIHFLRYVHFVLRTFQDVCLLGLMALSSGYMVTLLYRHKRQTQHLQSTKLSPKAPPEERATQTILLLMSFFVVMYFLDITVSWFSRKLWDIDSVHMCVQMLVGNGYASISPLVLISAEKRIIKVLKYIW", "length": 326, "header": "tr|F1N263-1|F1N263_BOVIN Isoform 1 of Vomeronasal type-1 receptor OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=F1N263-1" }, "isoforms": [ { "isoform_ac": "F1N263-1", "url": "https://www.uniprot.org/uniprotkb/F1N263/entry", "sequence": { "sequence": "SAHLLLFISPQVLTTCLFSSTKMNKNRLSSFIDIRNAFFSEVAIGILANTILLLFHAHNFLLEHRPKSTDLTIGHLALIHIVMLLTVAFMATDTFGSQKTWDDIQCKLVVHLYSSMRGLSICATCLLSVLRAITLSPRNSRLAKFKPHSSHHNLYCTLFLWVFNMFISGYFLVSTVATPSVTSAHLLHVTESCSLCPVIHFLRYVHFVLRTFQDVCLLGLMALSSGYMVTLLYRHKRQTQHLQSTKLSPKAPPEERATQTILLLMSFFVVMYFLDITVSWFSRKLWDIDSVHMCVQMLVGNGYASISPLVLISAEKRIIKVLKYIW", "length": 326, "header": "tr|F1N263-1|F1N263_BOVIN Isoform 1 of Vomeronasal type-1 receptor OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=F1N263-1" }, "locus": { "chromosome": "22", "start_pos": 58120750, "end_pos": 58119546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057245.5", "url": "https://www.ensembl.org/id/ENSBTAT00000057245.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052940.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052940.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 178, "start_aa": "Thr", "end_pos": 178, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr178", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:112443506", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112443506", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "response to pheromone", "id": "GO:0019236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019236", "evidence": [ { "database": "UniProtKB", "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263" } ], "pmid": "" }, { "name": "sensory perception of chemical stimulus", "id": "GO:0007606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007606", "evidence": [ { "database": "UniProtKB", "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pheromone binding", "id": "GO:0005550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005550", "evidence": [ { "database": "UniProtKB", "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263" } ], "pmid": "" }, { "name": "pheromone receptor activity", "id": "GO:0016503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016503", "evidence": [ { "database": "UniProtKB", "id": "F1N263", "url": "https://www.uniprot.org/uniprotkb/F1N263" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N263-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N263-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N263" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N263" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 311, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 178 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N293-1", "uniprot_ac": "F1N293", "uniprot_id": "F1N293_BOVIN", "mass": { "chemical_mass": 82956.0, "monoisotopic_mass": 82956.0 }, "refseq": {}, "gene_names": [ { "name": "CNNM3", "type": "recommended", "evidence": [ { "id": "F1N293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N293" } ] } ], "protein_names": [ { "name": "Metal transporter", "type": "recommended", "evidence": [ { "id": "F1N293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N293/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Metal transporter.", "evidence": [ { "database": "UniProtKB", "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293#function" }, { "database": "UniProtKB", "id": "RU369091", "url": "https://www.uniprot.org/uniprotkb/RU369091#function" }, { "database": "UniProtKB", "id": "A0A3Q1LWT5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNNM3", "url": "https://www.uniprot.org/uniprotkb/F1N293", "locus": { "chromosome": "11", "start_pos": 2795690, "end_pos": 2763245, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010846", "url": "https://www.ensembl.org/id/ENSBTAG00000010846" } ] } } ], "crossref": [ { "id": "F1N293", "url": "https://alphafold.ebi.ac.uk/entry/F1N293", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010846", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010846", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100138153", "url": "https://www.ncbi.nlm.nih.gov/gene/100138153", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138153", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138153", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KLMFMHA", "url": "https://omabrowser.org/oma/group/KLMFMHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWT5", "url": "https://www.orthodb.org/?gene=A0A3Q1LWT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N293", "url": "https://www.orthodb.org/?gene=F1N293", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12064:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12064:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LWT5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWT5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N293-1", "url": "https://www.uniprot.org/uniprotkb/F1N293-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAAAAGRLGWLLAALCLGNAAGEAAPDPRVLGVCLEEDGAAGAGWAHEGEVRAAPEATFRLRLFGSGFSNSSWSWVAPEGAGCPEGGPAAAPDEAAAPTGEWRALLRLRAEAARPHSVRLAVRGEPGGSAAEEAAALTGEWRALLRLRAEAARPHSALLAVRVEPGGSAAEEEAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALILSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLPCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEDERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESEDYRDTIVKKKPASLNAPLRQKEEFSLFKVSDDDCKVKISPQLLLATQRFLSREVDVFSPLRVSEKVLLHLLKHPSVNQEVRFDESNRLASHHYLYQRSRPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTAPSSVHQSPVSSLQSLRYDPPPEPTDGTCLSAYCPDYTVRALSDLQFIKVTRLQYLNALLATRAQALPQTPENTELLAIPGSQTRLLGDKAATAPDSVSYGLCSALVFTIGKKPTSHPTLQWGHRDLPEGCLCLALF", "length": 773, "header": "tr|F1N293-1|F1N293_BOVIN Isoform 1 of Metal transporter OS=Bos taurus OX=9913 GN=CNNM3 PE=3 SV=4 CANONICAL=F1N293-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWT5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT5/entry", "sequence": { "sequence": "MAAAAAAAGRLGWLLAALCLGNAAGEAAPDPRVLGVCLEEDGAAGAGWAHEGEVRAAPEATFRLRLFGSGFSNSSWSWVAPEGAGCPEGGPAAAPDEAAAPTGEWRALLRLRAEAARPHSVRLAVRGEPGGSAAEEAAALTGEWRALLRLRAEAARPHSALLAVRVEPGGSAAEEEAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALILSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLPCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEDERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESEDYRDTIVKKKPASLNAPLRQKEEFSLFKVSDDDCKVKISPQLLLATQRFLSREVDVFSPLRVSEKVLLHLLKHPSVNQEVRFDESNRLASHHYLYQRSRPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTAPSSVHQSPVSSLQSLRYDPPPEPTDGTCLSAYCPDYTVRALSDLQFIKVTRLQYLNALLATRAQALPQTPENTELLAIPGSQTRLLGDKAATAPGSNHSRPGLPAEESPGRNPGV", "length": 752, "header": "tr|A0A3Q1LWT5-1|A0A3Q1LWT5_BOVIN Computationally mapped isoform of Metal transporter OS=Bos taurus OX=9913 GN=CNNM3 PE=3 SV=2 CANONICAL=F1N293-1" }, "locus": { "chromosome": "11", "start_pos": 2794686, "end_pos": 2763444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075951.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075951.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061702.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061702.2" } ] } }, { "isoform_ac": "F1N293-1", "url": "https://www.uniprot.org/uniprotkb/F1N293/entry", "sequence": { "sequence": "MAAAAAAAGRLGWLLAALCLGNAAGEAAPDPRVLGVCLEEDGAAGAGWAHEGEVRAAPEATFRLRLFGSGFSNSSWSWVAPEGAGCPEGGPAAAPDEAAAPTGEWRALLRLRAEAARPHSVRLAVRGEPGGSAAEEAAALTGEWRALLRLRAEAARPHSALLAVRVEPGGSAAEEEAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALILSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLPCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEDERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESEDYRDTIVKKKPASLNAPLRQKEEFSLFKVSDDDCKVKISPQLLLATQRFLSREVDVFSPLRVSEKVLLHLLKHPSVNQEVRFDESNRLASHHYLYQRSRPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTAPSSVHQSPVSSLQSLRYDPPPEPTDGTCLSAYCPDYTVRALSDLQFIKVTRLQYLNALLATRAQALPQTPENTELLAIPGSQTRLLGDKAATAPDSVSYGLCSALVFTIGKKPTSHPTLQWGHRDLPEGCLCLALF", "length": 773, "header": "tr|F1N293-1|F1N293_BOVIN Isoform 1 of Metal transporter OS=Bos taurus OX=9913 GN=CNNM3 PE=3 SV=4 CANONICAL=F1N293-1" }, "locus": { "chromosome": "11", "start_pos": 2793266, "end_pos": 2763444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014394.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014394.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014394.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014394.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 661, "start_aa": "Thr", "end_pos": 661, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr661", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100138153", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138153", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QZI1-1", "protein_name": "Metal transporter", "gene_name": "CNNM3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAATAGRLGWLLAAFCLGNAAAEAAPGPRVLGVCLEEDGAAGTGWARGEEVRTAPEATFRLRLFGSGLANSSWSWVAPEGAGCPEGGPVAAPDEAAAPTGEWRALLRLRAEAAHPHSARLAVRGEPGGAAAPTGEWRALLRLRSESAHPHSALLAVRVEPGGEAAEEAAPPWAVGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPSRRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLLFLVGEVVPAAVSGRWTLALAPRALILSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLPCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESEDYRDTIVKKKPASLSAPLRQKEEFSLFKVSDDEYKVKISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLAAHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALAAPSSGKLQPPWCWGLGWQSQWPRPLAGRSALQPAGPSWLRAAWREGQPFFRAHLCCPSHPCRTSPGRACLFSSESPSDGGWPLEAVLLSPGQGWPAPPPTVLPVVPQSPVSSLQSVRHDLPPEPADGTRLSAYCPDYTVRALSDLQFIKVTRLQYLNALLATRAQALPQPSENADLQTIPGSQTRLLGDKAATAAGSNHSRPGLPVEESPGRNPGV", "length": 845 }, "evidence": [ { "id": "F1N293", "url": "https://omabrowser.org/oma/group/F1N293/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4ACK7-1", "protein_name": "Metal transporter", "gene_name": "Cnnm3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAAAAVAGWLGWVLAAFCLGSTAGEAAPGAGLLSFCTEEDGAPGAGSLRGRAAPEATLCLRLFCPGLANSSWTWVAPEGAGCPEGGRATEPSEAAAPTGEWRALLRLRAEAGHPRSALLAVRVEPGGGAAEEAAAPWALGLGAAGLLALAAVARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYGAVGQRAVPAVLGCAGLVFLVGEVLPAAVSGRWALALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLRYRTVEDVLTPLEDCFMLDSGTVLDFSVLASIMQSGHTRIPVFEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESEDYSDTKVKKKAVTLGAPLKRKEEFSLFKVSDDEYKVKISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVKFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTAPSSAHQSPVSSRQLIRHDLQPEPADSTRSCTYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQSLPPSPENAELQAIPGSQTRLLGDKSRETAGPSSSRRSIPVEESPGRNPGV", "length": 711 }, "evidence": [ { "id": "F1N293", "url": "https://omabrowser.org/oma/group/F1N293/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q32NY4-1", "protein_name": "Metal transporter CNNM3", "gene_name": "Cnnm3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAAAVVGWLGWVLAAFCLGSTAGEAAPAPGAGLLNFCTEEDSAPGAGSLRGRAAPEATLCLRLFCSGLANSSWTWVAAEGAGCPEGGRATEPEEAAAPTGEWRALLRLRAEAGHPRSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAAVARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYGAAGQRAVPAVLGCAGLVFLVGEVLPAAVSGRWALALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLRSRTVEDVLTPLEDCFMLDSGTVLDFSVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAIVEPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESEDYSDTKVRKKTVALGAPLKRKEEFSLFKVSDDEYKVKISPQLLLATQRFLSREVDVFSPLRVSEKVLLHLLKHPSVNQEVTFDESNRLAAHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTAPSSAHQSPVSSRQLIRHDVQPEPADGTRSCTYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQSLPPSPENAELQAIPGSQTRLLGDKSRETAGSTNSRPSIPVEESPGRNPGV", "length": 713 }, "evidence": [ { "id": "F1N293", "url": "https://omabrowser.org/oma/group/F1N293/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54W99-1", "protein_name": "CNNM transmembrane domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTSVQYYFFQWISIIVLVAISGLFAGLTLGIMSLDITGLEIIIASGTAKESKYAKIIYPVRQKGNLLLCTLLLGNVGVNALLSIFLADLTSGFVGFILSTTIIVIAGEIIPQAACSRHGLAVGAHTIYIVYVFIFLFFPFAYPISLTLDWILGNEMGTIYSRNQLKKLLDIHSAHANESGVSRSDVTMLTGVLDFAHKKVSLIMTPMERVFSVDIESLLDYNTITLILESGHSRIPVFEGNKSNIVGCLYVKDLALLNPADKVPLRTILNLYKRQLVKTWNDTSLDQMLTEFKTGRSHMAIVHKVNNEGEGDPFYENLGIICLEDIIEEILQDEILDENDMYHEVRKKNQHHSTFDYRTIGSFHGPKTALAQLSSQQVKAIYSYLSGSIDEFSSKFISENVFIKMLSTKGAIVLDVDRPATGDKFIYTRGVATDFFTIILQGKVEIRSGSEAFISEGGPFSTLGVGALKSDHFVPDFTARVISGNISYLKIPKSVYDQSVISTDDEYNTKIFNRNRVDLSGSSSSANVNTSSSSGHSRSISNDDRPTSSPIINNVSSSPNIPSSILTNNNNNNNNSTNTTTTTTTTTTSTKNKENESDNSESEDDSDDNYNSQKPILSTPKNNFLQNIRKSDTNI", "length": 635 }, "evidence": [ { "id": "F1N293", "url": "https://omabrowser.org/oma/group/F1N293/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8NE01-1", "protein_name": "Metal transporter CNNM3", "gene_name": "CNNM3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVAAAGRLGWLFAALCLGNAAGEAAPGPRVLGFCLEEDGAAGAGWVRGGAARDTPDATFLLRLFGPGFANSSWSWVAPEGAGCREEAASPAGEWRALLRLRLRAEAVRPHSALLAVRVEPGGGAAEEAAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRALGLSRLAVLLTLPVALPVGQLLELAARPGRLRERVLELARGGGDPYSDLSKGVLRCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESEDYRDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQRFLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSPVSSLQPIRHDLQPDPGDGTHSSAYCPDYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQSPENTDLQVIPGSQTRLLGEKTTTAAGSSHSRPGVPVEGSPGRNPGV", "length": 707 }, "evidence": [ { "id": "F1N293", "url": "https://omabrowser.org/oma/group/F1N293/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "monoatomic ion transport", "id": "GO:0006811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006811", "evidence": [ { "database": "UniProtKB", "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293" } ], "pmid": "" }, { "name": "magnesium ion homeostasis", "id": "GO:0010960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010960", "evidence": [ { "database": "UniProtKB", "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "F1N293", "url": "https://www.uniprot.org/uniprotkb/F1N293" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N293-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 773, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N293-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N293" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N293" }, { "id": "PS51371", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51371" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBS", "eco_id": "ECO_0000259", "start_pos": 431, "end_pos": 497, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N293" }, { "id": "PS51846", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51846" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CNNM transmembrane", "eco_id": "ECO_0000259", "start_pos": 175, "end_pos": 353, "start_aa": "Glu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 661 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 440, "end_pos": 442 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2C4-1", "uniprot_ac": "F1N2C4", "uniprot_id": "F1N2C4_BOVIN", "mass": { "chemical_mass": 34651.0, "monoisotopic_mass": 34651.0 }, "refseq": { "ac": "NP_001377274", "name": "olfactory receptor family 5 subfamily AK member 6", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377274" }, "gene_names": [ { "name": "OR5AK6", "type": "recommended", "evidence": [ { "id": "F1N2C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ] }, { "name": "OR5AK6", "type": "synonym", "evidence": [ { "id": "NP_001377274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377274" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N2C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2C4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 5 subfamily AK member 6", "type": "synonym", "evidence": [ { "id": "NP_001377274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377274" } ] }, { "name": "olfactory receptor, family 5, subfamily AK, member 2-like", "type": "synonym", "evidence": [ { "id": "NP_001377274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377274" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377274" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5AK6", "url": "https://www.uniprot.org/uniprotkb/F1N2C4", "locus": { "chromosome": "15", "start_pos": 80212514, "end_pos": 80211585, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069394", "url": "https://www.ensembl.org/id/ENSBTAG00000069394" } ] } } ], "crossref": [ { "id": "F1N2C4", "url": "https://alphafold.ebi.ac.uk/entry/F1N2C4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052129", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052129", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782866", "url": "https://www.ncbi.nlm.nih.gov/gene/782866", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782866", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782866", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QRKSWHI", "url": "https://omabrowser.org/oma/group/QRKSWHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2C4", "url": "https://www.orthodb.org/?gene=F1N2C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377274", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2C4-1", "url": "https://www.uniprot.org/uniprotkb/F1N2C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQNNGTTVTEFILLGFADQHKSWHVLFTVFLVIYVVTLVGNIGMILLIKTDSSLHTPMYFFLQNLAFVDLCYTSAITPKMLQSFVETKQSISFIGCMVQLLVYGAFATSDCYILAAMAVDRYVAICNPLRYETVMSQRVCSQLLTASYFMGFLNASVNTSFAFSLNFCKSNKISHFFCDAPPILALSCSSIYLNIMLLTVFVGFNLTFTVSVVIFSYVFILIAILKISSAAGRKKAFSTCVSHLTAVSIFYGTLSYMYLHHRTIESQEQEKMASVFYGIIIPMLNPLIYSLRNQDVREALKGVGKKCF", "length": 309, "header": "tr|F1N2C4-1|F1N2C4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5AK6 PE=3 SV=2 CANONICAL=F1N2C4-1" }, "isoforms": [ { "isoform_ac": "F1N2C4-1", "url": "https://www.uniprot.org/uniprotkb/F1N2C4/entry", "sequence": { "sequence": "MEQNNGTTVTEFILLGFADQHKSWHVLFTVFLVIYVVTLVGNIGMILLIKTDSSLHTPMYFFLQNLAFVDLCYTSAITPKMLQSFVETKQSISFIGCMVQLLVYGAFATSDCYILAAMAVDRYVAICNPLRYETVMSQRVCSQLLTASYFMGFLNASVNTSFAFSLNFCKSNKISHFFCDAPPILALSCSSIYLNIMLLTVFVGFNLTFTVSVVIFSYVFILIAILKISSAAGRKKAFSTCVSHLTAVSIFYGTLSYMYLHHRTIESQEQEKMASVFYGIIIPMLNPLIYSLRNQDVREALKGVGKKCF", "length": 309, "header": "tr|F1N2C4-1|F1N2C4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5AK6 PE=3 SV=2 CANONICAL=F1N2C4-1" }, "locus": { "chromosome": "15", "start_pos": 80212511, "end_pos": 80211585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053687.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053687.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052938.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052938.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782866", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782866", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FKV8-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259268", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTKVTEFILLAFAGQHKSWLVLFIVFLVTYVVTLVGNIGMILLIKIEASLHTPMYFFLQNLAFVDLCYATAITPKMLQNLLSTKRSISFIGCMVQLLVYGTFVTSDCYVLAAMAVDRYVAICNPLRYPTVMSQRVCIQLLIGSYFMGFLNASVNTSFTFQLNFCKSNKINHFFCDAPPILALSCSSIYFNIMLLAAFVGFNLTCTVSVVIFSYIFILAAILKISSAAGRKKAFSTCASHLTAVTLFYGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMLNPLIYSLRNQDVREALKGVGKQCF", "length": 309 }, "evidence": [ { "id": "F1N2C4", "url": "https://omabrowser.org/oma/group/F1N2C4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZXY0-1", "protein_name": "Olfactory receptor", "gene_name": "Or5ak4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGHSNDTKVTEFILLGFAGQHESWHILFVVFLIIYIATLVGNIGMILLIKLHSSLHTPMYFFLQHLAFVDLCYSSAITPKTLQNFVSSKPSISFTGCIVQLLVYGIFVTSDCFILAAMAVDRYVAICNPLRYPIIMSQRLCILLLLGSYTMGFLNATVNTGFTFLSNFCKSNTINHFFCDVPPILALSCSSIDLNIMVLTIFVGFNLTFTVSVVILSYTFILAAILRMSSAAGRRKAFSTCASHMTAVTIFYGTLSYMYVLHGTNKSQEQEKVASVFYGIMIPMLNPLIYSLRNQDVIGALRNIGNKCF", "length": 309 }, "evidence": [ { "id": "F1N2C4", "url": "https://omabrowser.org/oma/group/F1N2C4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TRA2-1", "protein_name": "Olfactory receptor", "gene_name": "Or5ak4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQSNDTKVTEFILLGFAGQHKSWHILFIIFLMIYVVTLMGNIGMIVLIKIDSSLHTPMYFFLQHLAFVDLCYTSAITPKMLKNFTETKASISFIGCMLQLLAYGTFATIDCFILAAMAVDRYVAICNPLRYPIVMSQRLCILLLVGSYTMGFLNASVNTSFTFSLKFCKSNAINHFFCDEPPILALSCSSIDFSIMLLTVFVGFNLLSTVLVVIFSYIYILSAILRMSSAAGRKKAFSTCASHLTAVTIFYGTLAYMYLHPHTNDSQEQEKAASVFYGIIIPMLNPLIYSLRNQDVIEAFKKIAKKCL", "length": 309 }, "evidence": [ { "id": "F1N2C4", "url": "https://omabrowser.org/oma/group/F1N2C4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "F1N2C4", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2C4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2C4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2C4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2C4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2D2-1", "uniprot_ac": "F1N2D2", "uniprot_id": "F1N2D2_BOVIN", "mass": { "chemical_mass": 38230.0, "monoisotopic_mass": 38230.0 }, "refseq": { "ac": "XP_005223154", "name": "chemokine XC receptor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223154" }, "gene_names": [ { "name": "XCR1", "type": "recommended", "evidence": [ { "id": "F1N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ] }, { "name": "XCR1", "type": "synonym", "evidence": [ { "id": "XP_005223154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223154" } ] } ], "protein_names": [ { "name": "Chemokine C-C motif receptor-like 2", "type": "recommended", "evidence": [ { "id": "F1N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2D2/entry#names_and_taxonomy" } ] }, { "name": "chemokine XC receptor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223154" } ] } ], "function": [ { "annotation": "Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses.", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2#function" }, { "database": "UniProtKB", "id": "ARBA00053413", "url": "https://www.uniprot.org/uniprotkb/ARBA00053413#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XCR1", "url": "https://www.uniprot.org/uniprotkb/F1N2D2", "locus": { "chromosome": "22", "start_pos": 53324371, "end_pos": 53300562, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063018", "url": "https://www.ensembl.org/id/ENSBTAG00000063018" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617880", "url": "https://www.ncbi.nlm.nih.gov/gene/617880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RSHTKNR", "url": "https://omabrowser.org/oma/group/RSHTKNR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2D2", "url": "https://www.orthodb.org/?gene=F1N2D2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10489:SF730", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10489:SF730", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-380108", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005223154", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223154", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2D2-1", "url": "https://www.uniprot.org/uniprotkb/F1N2D2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPSDIPESTTFYEYDPQSFLCEKRTFVFATVSTTILYCLVFFLSLVGNSLVLWVLVKYESLESLTNVFILNLCLSDLVFSCLLPVWILGYHWGWVLGDLLCKLLNMVFSISLYSSISFLTIMTIHRYLSVVSPISSLRVHTLQRRVLVTAAVWAASILSSIPDAIFHKVFPSGCDYSELEGFLASVYQHNVIFLLSVGVILFCYVEILRTLFRSRSKRRHRTVRLIFTIVAAYFLSWAPYNLILFLQTLLKLGVIQSCEVSQQLDYALLICRNVAFSHCCFNPVLYVFVGVKFRRHLKSLLRRFWLCRQQAPSLPPSPHPPGAFTYEGISFY", "length": 333, "header": "tr|F1N2D2-1|F1N2D2_BOVIN Isoform 1 of Chemokine C-C motif receptor-like 2 OS=Bos taurus OX=9913 GN=XCR1 PE=3 SV=3 CANONICAL=F1N2D2-1" }, "isoforms": [ { "isoform_ac": "F1N2D2-1", "url": "https://www.uniprot.org/uniprotkb/F1N2D2/entry", "sequence": { "sequence": "MEPSDIPESTTFYEYDPQSFLCEKRTFVFATVSTTILYCLVFFLSLVGNSLVLWVLVKYESLESLTNVFILNLCLSDLVFSCLLPVWILGYHWGWVLGDLLCKLLNMVFSISLYSSISFLTIMTIHRYLSVVSPISSLRVHTLQRRVLVTAAVWAASILSSIPDAIFHKVFPSGCDYSELEGFLASVYQHNVIFLLSVGVILFCYVEILRTLFRSRSKRRHRTVRLIFTIVAAYFLSWAPYNLILFLQTLLKLGVIQSCEVSQQLDYALLICRNVAFSHCCFNPVLYVFVGVKFRRHLKSLLRRFWLCRQQAPSLPPSPHPPGAFTYEGISFY", "length": 333, "header": "tr|F1N2D2-1|F1N2D2_BOVIN Isoform 1 of Chemokine C-C motif receptor-like 2 OS=Bos taurus OX=9913 GN=XCR1 PE=3 SV=3 CANONICAL=F1N2D2-1" }, "locus": { "chromosome": "22", "start_pos": 53320179, "end_pos": 53319181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130202.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130202.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091110.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-380108", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "resource": "Reactome", "description": "Chemokine receptors bind chemokines" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z0Z5-1", "protein_name": "X-C motif chemokine receptor 1", "gene_name": "XCR1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDEEQYPSGWDDNYSFEYVLNESNVCEMGNYFIFYTHFTTVLYTLAFLLSLLGNTLVLWILFKYENLTSLTNIFIMNLCISDLVFSCMLPFWAVDQTFGWIFGEFLCKAVNAIFSIGYYSGVFFLTLMTILRYLSVVSPLSTLRSQTQYCGSLVCLLVWTCSILIVVPEMIHTTVVETLEEVSTCDYDDWKWKKVDIYQRNILFLISFGIIIFCYINILIILLRTRSRRKHRTVKLILVIVVAFFLSWAPYNILSFLITFPPPTCQYEKDTLLAFHISRKIAFSHCCLNPVLYVFAGVKFKSHLFRLCGQYLPCCDEVSRIGSQARFHYEDASIY", "length": 335 }, "evidence": [ { "id": "F1N2D2", "url": "https://omabrowser.org/oma/group/F1N2D2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P46094-1", "protein_name": "Chemokine XC receptor 1", "gene_name": "XCR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESSGNPESTTFFYYDLQSQPCENQAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWGWVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLSTLRVPTLRCRVLVTMAVWVASILSSILDTIFHKVLSSGCDYSELTWYLTSVYQHNLFFLLSLGIILFCYVEILRTLFRSRSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQIIRSCEAKQQLEYALLICRNLAFSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASIPHSPGAFAYEGASFY", "length": 333 }, "evidence": [ { "id": "F1N2D2", "url": "https://omabrowser.org/oma/group/F1N2D2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R0M1-1", "protein_name": "Chemokine XC receptor 1", "gene_name": "Xcr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESSTAFYDYHDKLSLLCENNVIFFSTISTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLISAQWSWFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPISTLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVISLNCKYSEHHGFLASVYQHNIFFLLSMGIILFCYVQILRTLFRTRSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKTGIIQQSCESLQQLDIAMIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTSSTVPCSPGTFTYEGPSFY", "length": 322 }, "evidence": [ { "id": "F1N2D2", "url": "https://omabrowser.org/oma/group/F1N2D2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" }, { "name": "positive regulation of cytosolic calcium ion concentration", "id": "GO:0007204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007204", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" }, { "name": "calcium-mediated signaling", "id": "GO:0019722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" }, { "name": "cell chemotaxis", "id": "GO:0060326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "C-C chemokine receptor activity", "id": "GO:0016493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016493", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" }, { "name": "C-C chemokine binding", "id": "GO:0019957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019957", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N2D2", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2D2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2G3-1", "uniprot_ac": "F1N2G3", "uniprot_id": "F1N2G3_BOVIN", "mass": { "chemical_mass": 34729.0, "monoisotopic_mass": 34729.0 }, "refseq": { "ac": "XP_002698203", "name": "olfactory receptor 10AC1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698203" }, "gene_names": [ { "name": "OR10AH1", "type": "recommended", "evidence": [ { "id": "F1N2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" } ] }, { "name": "OR10AH1", "type": "synonym", "evidence": [ { "id": "XP_002698203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698203" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10AC1", "type": "synonym", "evidence": [ { "id": "XP_002698203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698203" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10AH1", "url": "https://www.uniprot.org/uniprotkb/F1N2G3", "locus": { "chromosome": "25", "start_pos": 38576635, "end_pos": 38553158, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005600", "url": "https://www.ensembl.org/id/ENSBTAG00000005600" } ] } } ], "crossref": [ { "id": "618554", "url": "https://www.ncbi.nlm.nih.gov/gene/618554", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618554", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618554", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698203", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698203", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2G3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHWPESNWSAPWEFVILGFSGWPPELRALLFALLLPLYLATLTGNLLIVGLAVVDAALHTPMYFFLGALSAVEVAYTLVLTPPMLAGFLLPPGGQAVGLSTCAAQMGLFVALGGSECLLLAAMALDRYLAICHPLYYPQLMTMGLCWCLLACCGLGGSLLALGLTTAIFQLPFCHGGLVNHVFCDLPAVLVLACGDRDLQERALLAACLLLLVLPLALILLSYTRVLAVILGVGGATGRRKAFSTVASHLTVAVLHYGCATAMYARPLRSRSLEEDKLVSLIYINLTPLLYPAIYTLRNRDVQGALWRAVGPRTPGAAHQANVT", "length": 325, "header": "tr|F1N2G3-1|F1N2G3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10AH1 PE=3 SV=4 CANONICAL=F1N2G3-1" }, "isoforms": [ { "isoform_ac": "F1N2G3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G3/entry", "sequence": { "sequence": "MSHWPESNWSAPWEFVILGFSGWPPELRALLFALLLPLYLATLTGNLLIVGLAVVDAALHTPMYFFLGALSAVEVAYTLVLTPPMLAGFLLPPGGQAVGLSTCAAQMGLFVALGGSECLLLAAMALDRYLAICHPLYYPQLMTMGLCWCLLACCGLGGSLLALGLTTAIFQLPFCHGGLVNHVFCDLPAVLVLACGDRDLQERALLAACLLLLVLPLALILLSYTRVLAVILGVGGATGRRKAFSTVASHLTVAVLHYGCATAMYARPLRSRSLEEDKLVSLIYINLTPLLYPAIYTLRNRDVQGALWRAVGPRTPGAAHQANVT", "length": 325, "header": "tr|F1N2G3-1|F1N2G3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10AH1 PE=3 SV=4 CANONICAL=F1N2G3-1" }, "locus": { "chromosome": "25", "start_pos": 38576143, "end_pos": 38575169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093357.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093357.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103255.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103255.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618554", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618554", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N2G3", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 296, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2G5-1", "uniprot_ac": "F1N2G5", "uniprot_id": "F1N2G5_BOVIN", "mass": { "chemical_mass": 179927.0, "monoisotopic_mass": 179927.0 }, "refseq": {}, "gene_names": [ { "name": "ARHGEF5", "type": "recommended", "evidence": [ { "id": "F1N2G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ] } ], "protein_names": [ { "name": "Rho guanine nucleotide exchange factor 5", "type": "synonym", "evidence": [ { "id": "F1N2G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGEF5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5", "locus": { "chromosome": "4", "start_pos": 107650869, "end_pos": 107620041, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001815", "url": "https://www.ensembl.org/id/ENSBTAG00000001815" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001815", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001815", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01221", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01221", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11940", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11940", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N2G5", "url": "https://www.orthodb.org/?gene=F1N2G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12845:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12845:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2G5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPRRGPAPALPQEGVSLVSSPETSEENQIPPSRPGGAAGACAGDGRPAGDPRARGGAPGQHVTLTQDSVLMEAEEPQHGASTPIPARAEFPVIWAPPMRSSKTPALEPAAEEGEDPRCQWAEGCTLLETQQRHVRDANDRAAERMTSLLNEASPEVETDQETLMAEACDDTPSCQEAGPWSLEDRQARTPASLDFLTCPDQGDCLDTASVSRDLDTSVEVDFKPELTSLILETGQAEGKEETSSNAYARTRHRPSCDDEHPAETSRPLEDSECGPARQESPGLVCLQGTEGLEEGGPQGEAAGSAGLSGAPEQMGEQVKGAEEEGRQKQQQMQNDMVLEDPGEREGWCCGEELGGLSYGEWDWRTWSHGDPEQGEQKGRELTGPEENEVGAQDGENQSSASKSEKGSGKPEDPGAQWEAKAAEGQEEEVGSLEEEPGGGEGDTPSRGGEESCIEQGEREGPTALALVAPEVSPPRDLSLEASSPLSRIPGTQTEPGAEVPSPIAPSPAPEPTGCSHQPFSLPGSCPAEESLDPETAHRHQQEGSELGQETAHGVGAEVVSAYSPSATPPRSPEAAAPSPPEGPPGTAATPMARPLAASPRREPPVLACSPETSRASCPTDSPSPHGAPKTPPAACYGFPLAGRANPPGSLGSPTGAVQPVRSNSFPGSHGTEPAPHLAGISLSSSHSELPQRPPKPVIYGSVLPRRGRRTVRDCAIIPEASSSPPTPGQDFGELASNPATAGSPPDSQPWGPTKHWAFAPGSPACGSSPAPAAPMDLMIHEPPPLPPLERRHVQPSTVEPDGHPPAVIPMLKRYSHPPPLTLGPGLHGPPRVPPAHIPDPLVAREHRPLPSTPDAPPHTQHSVSSRQRYNKPLPPTPDAPQPHHPLVLSSISRIYKPLPPVPILDSPTEPPPLPPKSKGKGRSSQGGLVNSGDQGRPRPVCQEWTVSTPPSAGRVSWPPATGRSTDPLASVGRCKSDTPPGLAFSNMTALLHPSSPTTPWTPEVQRPTSEPGLSEESEAPARGSWRRTAPQEGSNGLRRSEVGPVRQPEKSGHILLEKASSWPHRRDPRRPVEGGSEVAAVPGEGSSKHKDWHRQGLRRPSILPESPVDTRGPAMEGSPGLSDAIVFREKKPKEVMGNFSRRCSKLINSSQLLYQEYSDVFLNKEIQSQQRLDSLTESPGPISPRQPRKALVSSESYLRRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEAKFELIVSEASYLRSLHIAVDHFQHSEQLRATLSNQDHQWLFSRLQDVRDVSTMFLSDLEENFENNIFTFQVCDVVLNHAPNFRRVYLPYVTNQTYQERTFQSLLNSNSSFREVLEKLESAPICQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSAEEAEATKAHHALEELIRDCNNNVQRMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALELSVSQALRRKLTTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSAVRGEKCEMKLHGAHKNLFRLFLRRNAQGSQAEFLLRTETQSEKLRWISALAMPREELDLLECYDSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGEQGWFPLQQVEFISNPEVRARNLKEAHRVKTAKLQLVEQQT", "length": 1655, "header": "tr|F1N2G5-1|F1N2G5_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 5 OS=Bos taurus OX=9913 GN=ARHGEF5 PE=4 SV=3 CANONICAL=F1N2G5-1" }, "isoforms": [ { "isoform_ac": "F1N2G5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G5/entry", "sequence": { "sequence": "MRPRRGPAPALPQEGVSLVSSPETSEENQIPPSRPGGAAGACAGDGRPAGDPRARGGAPGQHVTLTQDSVLMEAEEPQHGASTPIPARAEFPVIWAPPMRSSKTPALEPAAEEGEDPRCQWAEGCTLLETQQRHVRDANDRAAERMTSLLNEASPEVETDQETLMAEACDDTPSCQEAGPWSLEDRQARTPASLDFLTCPDQGDCLDTASVSRDLDTSVEVDFKPELTSLILETGQAEGKEETSSNAYARTRHRPSCDDEHPAETSRPLEDSECGPARQESPGLVCLQGTEGLEEGGPQGEAAGSAGLSGAPEQMGEQVKGAEEEGRQKQQQMQNDMVLEDPGEREGWCCGEELGGLSYGEWDWRTWSHGDPEQGEQKGRELTGPEENEVGAQDGENQSSASKSEKGSGKPEDPGAQWEAKAAEGQEEEVGSLEEEPGGGEGDTPSRGGEESCIEQGEREGPTALALVAPEVSPPRDLSLEASSPLSRIPGTQTEPGAEVPSPIAPSPAPEPTGCSHQPFSLPGSCPAEESLDPETAHRHQQEGSELGQETAHGVGAEVVSAYSPSATPPRSPEAAAPSPPEGPPGTAATPMARPLAASPRREPPVLACSPETSRASCPTDSPSPHGAPKTPPAACYGFPLAGRANPPGSLGSPTGAVQPVRSNSFPGSHGTEPAPHLAGISLSSSHSELPQRPPKPVIYGSVLPRRGRRTVRDCAIIPEASSSPPTPGQDFGELASNPATAGSPPDSQPWGPTKHWAFAPGSPACGSSPAPAAPMDLMIHEPPPLPPLERRHVQPSTVEPDGHPPAVIPMLKRYSHPPPLTLGPGLHGPPRVPPAHIPDPLVAREHRPLPSTPDAPPHTQHSVSSRQRYNKPLPPTPDAPQPHHPLVLSSISRIYKPLPPVPILDSPTEPPPLPPKSKGKGRSSQGGLVNSGDQGRPRPVCQEWTVSTPPSAGRVSWPPATGRSTDPLASVGRCKSDTPPGLAFSNMTALLHPSSPTTPWTPEVQRPTSEPGLSEESEAPARGSWRRTAPQEGSNGLRRSEVGPVRQPEKSGHILLEKASSWPHRRDPRRPVEGGSEVAAVPGEGSSKHKDWHRQGLRRPSILPESPVDTRGPAMEGSPGLSDAIVFREKKPKEVMGNFSRRCSKLINSSQLLYQEYSDVFLNKEIQSQQRLDSLTESPGPISPRQPRKALVSSESYLRRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEAKFELIVSEASYLRSLHIAVDHFQHSEQLRATLSNQDHQWLFSRLQDVRDVSTMFLSDLEENFENNIFTFQVCDVVLNHAPNFRRVYLPYVTNQTYQERTFQSLLNSNSSFREVLEKLESAPICQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSAEEAEATKAHHALEELIRDCNNNVQRMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALELSVSQALRRKLTTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSAVRGEKCEMKLHGAHKNLFRLFLRRNAQGSQAEFLLRTETQSEKLRWISALAMPREELDLLECYDSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGEQGWFPLQQVEFISNPEVRARNLKEAHRVKTAKLQLVEQQT", "length": 1655, "header": "tr|F1N2G5-1|F1N2G5_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 5 OS=Bos taurus OX=9913 GN=ARHGEF5 PE=4 SV=3 CANONICAL=F1N2G5-1" }, "locus": { "chromosome": "4", "start_pos": 107650322, "end_pos": 107620138, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002373.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002373.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002373.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002373.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 444, "start_aa": "Thr", "end_pos": 444, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr444", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 568, "start_aa": "Thr", "end_pos": 568, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr568", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 727, "start_aa": "Thr", "end_pos": 727, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr727", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 877, "start_aa": "Thr", "end_pos": 877, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr877", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N2G5", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1139, "end_pos": 1141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1149, "end_pos": 1151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1219, "end_pos": 1221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1328, "end_pos": 1330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1343, "end_pos": 1345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 987, "end_pos": 989, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 1232, "end_pos": 1416, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G5" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 1568, "end_pos": 1629, "start_aa": "Tyr", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 444, 568, 727, 877 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1139, "end_pos": 1141 }, { "start_pos": 1149, "end_pos": 1151 }, { "start_pos": 1219, "end_pos": 1221 }, { "start_pos": 1328, "end_pos": 1330 }, { "start_pos": 1343, "end_pos": 1345 }, { "start_pos": 397, "end_pos": 399 }, { "start_pos": 987, "end_pos": 989 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2G6-1", "uniprot_ac": "F1N2G6", "uniprot_id": "F1N2G6_BOVIN", "mass": { "chemical_mass": 35610.0, "monoisotopic_mass": 35610.0 }, "refseq": {}, "gene_names": [ { "name": "TAS2R42", "type": "recommended", "evidence": [ { "id": "F1N2G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G6" } ] } ], "protein_names": [ { "name": "Taste receptor type 2", "type": "recommended", "evidence": [ { "id": "F1N2G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2G6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2G6", "url": "https://www.uniprot.org/uniprotkb/F1N2G6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAS2R42", "url": "https://www.uniprot.org/uniprotkb/F1N2G6", "locus": { "chromosome": "5", "start_pos": 98559755, "end_pos": 98558817, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030472", "url": "https://www.ensembl.org/id/ENSBTAG00000030472" } ] } } ], "crossref": [ { "id": "F1N2G6", "url": "https://alphafold.ebi.ac.uk/entry/F1N2G6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030472", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030472", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15024", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15024", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ATWFATC", "url": "https://omabrowser.org/oma/group/ATWFATC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2G6", "url": "https://www.orthodb.org/?gene=F1N2G6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11394:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11394:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N2G6", "url": "https://www.uniprot.org/uniprotkb/F1N2G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2G6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSGIENTFLAATIGGFLIGILGNGFIVLVNCIDLVKRQKLSSADCILTGLAISRISQLWVILCDSFLLVLWPHLYAIDKLTKVVSSFWILSNHLATWFATCLSVFYFFKVANFSHPCFTWLRWRIRSVVLVLLLGSLSLLFLNYESIYTLSHILTNSYKIYVRNSTWSSDVSETHYLHQLIVFNFINLIPFLLSLTSLLLLVLSLMRHIRNLQFNPSSKDLSTEAHKRAMKIVMSFLFLFIIHVSSILLIAWVFLKLQGRLAQLVVVLTSTVFPSSHSFILILGNSKLRQNALRLLWYLNCHPKRVKSLAS", "length": 312, "header": "tr|F1N2G6-1|F1N2G6_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R42 PE=3 SV=1 CANONICAL=F1N2G6-1" }, "isoforms": [ { "isoform_ac": "F1N2G6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G6/entry", "sequence": { "sequence": "MPSGIENTFLAATIGGFLIGILGNGFIVLVNCIDLVKRQKLSSADCILTGLAISRISQLWVILCDSFLLVLWPHLYAIDKLTKVVSSFWILSNHLATWFATCLSVFYFFKVANFSHPCFTWLRWRIRSVVLVLLLGSLSLLFLNYESIYTLSHILTNSYKIYVRNSTWSSDVSETHYLHQLIVFNFINLIPFLLSLTSLLLLVLSLMRHIRNLQFNPSSKDLSTEAHKRAMKIVMSFLFLFIIHVSSILLIAWVFLKLQGRLAQLVVVLTSTVFPSSHSFILILGNSKLRQNALRLLWYLNCHPKRVKSLAS", "length": 312, "header": "tr|F1N2G6-1|F1N2G6_BOVIN Isoform 1 of Taste receptor type 2 OS=Bos taurus OX=9913 GN=TAS2R42 PE=3 SV=1 CANONICAL=F1N2G6-1" }, "locus": { "chromosome": "5", "start_pos": 98559752, "end_pos": 98558817, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043010.2", "url": "https://www.ensembl.org/id/ENSBTAT00000043010.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040608.1", "url": "https://www.ensembl.org/id/ENSBTAP00000040608.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N2G6", "url": "https://www.uniprot.org/uniprotkb/F1N2G6" } ], "pmid": "" }, { "name": "bitter taste receptor activity", "id": "GO:0033038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033038", "evidence": [ { "database": "UniProtKB", "id": "F1N2G6", "url": "https://www.uniprot.org/uniprotkb/F1N2G6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N2G6", "url": "https://www.uniprot.org/uniprotkb/F1N2G6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2G6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2G6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2G6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 165, "end_pos": 167 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2J5-1", "uniprot_ac": "F1N2J5", "uniprot_id": "F1N2J5_BOVIN", "mass": { "chemical_mass": 42728.0, "monoisotopic_mass": 42728.0 }, "refseq": { "ac": "XP_002688581", "name": "hyaluronan and proteoglycan link protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688581" }, "gene_names": [ { "name": "HAPLN4", "type": "recommended", "evidence": [ { "id": "F1N2J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ] }, { "name": "HAPLN4", "type": "synonym", "evidence": [ { "id": "XP_002688581", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688581" } ] } ], "protein_names": [ { "name": "Hyaluronan and proteoglycan link protein 4", "type": "recommended", "evidence": [ { "id": "F1N2J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J5/entry#names_and_taxonomy" } ] }, { "name": "Brain link protein 2", "type": "synonym", "evidence": [ { "id": "F1N2J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J5/entry#names_and_taxonomy" } ] }, { "name": "hyaluronan and proteoglycan link protein 4", "type": "synonym", "evidence": [ { "id": "XP_002688581", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688581" } ] } ], "function": [ { "annotation": "Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs. Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons.", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5#function" }, { "database": "UniProtKB", "id": "ARBA00057003", "url": "https://www.uniprot.org/uniprotkb/ARBA00057003#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAPLN4", "url": "https://www.uniprot.org/uniprotkb/F1N2J5", "locus": { "chromosome": "7", "start_pos": 4016601, "end_pos": 4011093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001765", "url": "https://www.ensembl.org/id/ENSBTAG00000001765" } ] } } ], "crossref": [ { "id": "F1N2J5", "url": "https://alphafold.ebi.ac.uk/entry/F1N2J5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001765", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001765", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539254", "url": "https://www.ncbi.nlm.nih.gov/gene/539254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539254", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539254", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QACLQQD", "url": "https://omabrowser.org/oma/group/QACLQQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2J5", "url": "https://www.orthodb.org/?gene=F1N2J5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22804", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22804", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22804:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22804:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688581", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688581", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2J5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2J5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVCARAALGPGALWAAAWGVLLLTAAAEAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAATHGHDGVRLKWTKVVDPLAFADVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVTLQDYGRYECEVTNELEDDTGMVKLDLEGVVFPYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVSQPREPCGGLGGAGSAGAGGGASGGVRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSLGFPDASRRLFGVYCYRAPGAPDPAPGGWGWGWAGGGGWAGGSRDPAAWTPLRV", "length": 402, "header": "tr|F1N2J5-1|F1N2J5_BOVIN Isoform 1 of Hyaluronan and proteoglycan link protein 4 OS=Bos taurus OX=9913 GN=HAPLN4 PE=3 SV=3 CANONICAL=F1N2J5-1" }, "isoforms": [ { "isoform_ac": "F1N2J5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2J5/entry", "sequence": { "sequence": "MVCARAALGPGALWAAAWGVLLLTAAAEAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAATHGHDGVRLKWTKVVDPLAFADVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVTLQDYGRYECEVTNELEDDTGMVKLDLEGVVFPYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVSQPREPCGGLGGAGSAGAGGGASGGVRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSLGFPDASRRLFGVYCYRAPGAPDPAPGGWGWGWAGGGGWAGGSRDPAAWTPLRV", "length": 402, "header": "tr|F1N2J5-1|F1N2J5_BOVIN Isoform 1 of Hyaluronan and proteoglycan link protein 4 OS=Bos taurus OX=9913 GN=HAPLN4 PE=3 SV=3 CANONICAL=F1N2J5-1" }, "locus": { "chromosome": "7", "start_pos": 4015597, "end_pos": 4011175, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002313.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002313.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002313.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002313.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539254", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539254", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZL35-1", "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "HAPLN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVCARAALGPGALWAAVWGFLLLTAAAEAQRGRKKVVHVLEGASGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFADVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVTLQDYGRYECEVTNELEDDTGMVKLDLEGVVFPYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVSQPREPCGGLGQAGSAGAGGGVSGGVRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPLPFSGAARACAARGAAVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGSRPGVRSLGFPDAARRLFGVYCYRAPGAPDPAPGGWGWGWAGGGGWAGGARDPAAWTPLRV", "length": 402 }, "evidence": [ { "id": "F1N2J5", "url": "https://omabrowser.org/oma/group/F1N2J5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M2BHT5-1", "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "hapln4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRRWTSAVKRDSQKRDSCTTARLSLSSNNFIPSQHQTRHCMMMILFLEILTCTLLLLCPFVTSYPADLEKGRRRVVHVMEDDTGAVIVQTAPGKVVTHRGGTITLPCRYHHEPEDIDPNRIRIKWTKVSDAFQFEDVFVALGRQQKAFGSYQERVSLEQAGPGDASVIIHNITLEDYGRYECEVTNDMEDDTGFVNLDLEGVVFPYYPPSGRYKLNYHQAEEVCREQDAILASHPQLHKAWLEGLDWCNAGWLEDGSVQYPISHPRDQCGRKDSPPGVRNYGYRHKDDERYDAFCFTSNLNGRVYFLKRFKKVNYLEAVKACQRDGAFIAKVGQLYAAWKIQLLDRCEAGWVEDGSIRYPIVNPRARCGGPDPGVRNLGFPDKKFRLYGVYCFRKNTDIQSTQTPTETTSKMANSTRSI", "length": 419 }, "evidence": [ { "id": "F1N2J5", "url": "https://omabrowser.org/oma/group/F1N2J5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0LGA2-1", "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "Hapln4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLLSGSTSVTLGMEYQLSPVRLVNAVLLGKRLRWIIITVLSTPCAWGLPHPHPARCARVRAAPLMPHAPSSPCRQTPGLRGPRDQLARPLCACAVGKRTGRSAGATTRMACAPGALGHRALWAVAWGLLLLVPVLAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFADVFVALGPQHRAFGPYRGRAELQNDGPGDASLVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPRGGRYKMTFAEAQRACAEQDGILASAEQLHTAWRDGLDWCNAGWLRDGSVQYPVSQAREACGGSGSPGAGGGTNGGVRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVALAGAVRACAARGATVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRTRCGGPRPGVRSLGFPDASRRLFGVYCYRAPGAPDPAPGGWGWGWAGGGGWAGGSRDPAAWTPLRV", "length": 509 }, "evidence": [ { "id": "F1N2J5", "url": "https://omabrowser.org/oma/group/F1N2J5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80WM4-1", "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "Hapln4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACAPGALGHRALWAVAWGLLLLVPVLAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFADVFVALGPQHRAFGPYRGRAELQNDGPGDASLVLRNVTLQDYGRYECEVTNELEDDVGMVKLDLEGVVFPYHPRGGRYKMTFVEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVSHAREPCGGTGSTGAGGGTNGGVRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVALAGAVRACAARGATVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRTRCGGPRPGVRSLGFPDASRRLFGVYCYRAPGAPDPAPGGWGWGWAGGGGWAGGSRDPAAWTPLRV", "length": 400 }, "evidence": [ { "id": "F1N2J5", "url": "https://omabrowser.org/oma/group/F1N2J5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86UW8-1", "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "HAPLN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVCARAALGPGALWAAAWGVLLLTAPAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHRGGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQGDGPGDASLVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVNRPREPCGGLGGTGSAGGGGDANGGLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAVAKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSLGFPDATRRLFGVYCYRAPGAPDPAPGGWGWGWAGGGGWAGGARDPAAWTPLHV", "length": 402 }, "evidence": [ { "id": "F1N2J5", "url": "https://omabrowser.org/oma/group/F1N2J5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "perineuronal net", "id": "GO:0072534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072534", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "skeletal system development", "id": "GO:0001501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "synaptic transmission, GABAergic", "id": "GO:0051932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051932", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "inhibitory synapse assembly", "id": "GO:1904862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904862", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" }, { "name": "structural constituent of synapse-associated extracellular matrix", "id": "GO:0150043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150043", "evidence": [ { "database": "UniProtKB", "id": "F1N2J5", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2J5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 402, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2J5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2J5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 161, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J5" }, { "id": "PS50963", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50963" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link", "eco_id": "ECO_0000259", "start_pos": 163, "end_pos": 268, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2K0-1", "uniprot_ac": "F1N2K0", "uniprot_id": "F1N2K0_BOVIN", "mass": { "chemical_mass": 67842.0, "monoisotopic_mass": 67842.0 }, "refseq": { "ac": "NP_001421693", "name": "ankyrin repeat domain-containing protein 13D isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421693" }, "gene_names": [ { "name": "ANKRD13D", "type": "recommended", "evidence": [ { "id": "F1N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ] }, { "name": "ANKRD13D", "type": "synonym", "evidence": [ { "id": "NP_001421693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421693" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 13D", "type": "synonym", "evidence": [ { "id": "F1N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K0/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain 13 family, member D", "type": "synonym", "evidence": [ { "id": "NP_001421693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421693" } ] }, { "name": "ankyrin repeat domain-containing protein 13D isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421693" } ] } ], "function": [ { "annotation": "Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0#function" }, { "database": "UniProtKB", "id": "ARBA00024956", "url": "https://www.uniprot.org/uniprotkb/ARBA00024956#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD13D", "url": "https://www.uniprot.org/uniprotkb/F1N2K0", "locus": { "chromosome": "29", "start_pos": 45223424, "end_pos": 45212108, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012200", "url": "https://www.ensembl.org/id/ENSBTAG00000012200" } ] } } ], "crossref": [ { "id": "F1N2K0", "url": "https://alphafold.ebi.ac.uk/entry/F1N2K0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012200", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012200", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505682", "url": "https://www.ncbi.nlm.nih.gov/gene/505682", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TQKFRAN", "url": "https://omabrowser.org/oma/group/TQKFRAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2K0", "url": "https://www.orthodb.org/?gene=F1N2K0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12447", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12447", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12447:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12447:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11904", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11904", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2K0-1", "url": "https://www.uniprot.org/uniprotkb/F1N2K0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPGPTFPLHRLVWANRHRELEAALHSRQHDIEQEDPRGRTPLELAVSLGNLESVRVLLRHNANVGKESCQGWAVLQEAVSTGDPEMVQLVLQYRDYQRAMQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFKGQEAGALVMEVDHDRQVVHTETLGLALHEPEALLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKARIKGGKTPFQSFLGMAQQHSSHNGAPVQQAASPTNPTAISPDEYFDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPLSSVWVPAPGSAVATSGNPFPCEVDPAVFEVPEGYSVLGAERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGVHHAQATAYEEQLQLERALQESLRMSTEPGGPGSPHRTPPTPAPPSFEEQLRLALELSSQEQEERERLGQQEEEDLQRILQLSLTEH", "length": 604, "header": "tr|F1N2K0-1|F1N2K0_BOVIN Isoform 1 of Ankyrin repeat domain 13D OS=Bos taurus OX=9913 GN=ANKRD13D PE=4 SV=3 CANONICAL=F1N2K0-1" }, "isoforms": [ { "isoform_ac": "F1N2K0-1", "url": "https://www.uniprot.org/uniprotkb/F1N2K0/entry", "sequence": { "sequence": "MAGPGPTFPLHRLVWANRHRELEAALHSRQHDIEQEDPRGRTPLELAVSLGNLESVRVLLRHNANVGKESCQGWAVLQEAVSTGDPEMVQLVLQYRDYQRAMQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFKGQEAGALVMEVDHDRQVVHTETLGLALHEPEALLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKARIKGGKTPFQSFLGMAQQHSSHNGAPVQQAASPTNPTAISPDEYFDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPLSSVWVPAPGSAVATSGNPFPCEVDPAVFEVPEGYSVLGAERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGVHHAQATAYEEQLQLERALQESLRMSTEPGGPGSPHRTPPTPAPPSFEEQLRLALELSSQEQEERERLGQQEEEDLQRILQLSLTEH", "length": 604, "header": "tr|F1N2K0-1|F1N2K0_BOVIN Isoform 1 of Ankyrin repeat domain 13D OS=Bos taurus OX=9913 GN=ANKRD13D PE=4 SV=3 CANONICAL=F1N2K0-1" }, "locus": { "chromosome": "29", "start_pos": 45223265, "end_pos": 45212136, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030045.7", "url": "https://www.ensembl.org/id/ENSBTAT00000030045.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030033.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030033.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 558, "start_aa": "Thr", "end_pos": 558, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr558", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MB90-1", "protein_name": "Ankyrin repeat domain-containing protein 13D", "gene_name": "Ankrd13d", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGVGPTFPLHRLVWANRHRELEAALHSRQHDIEQEDPRGRTPLELAVSLGNLESVRVLLRHNANVGKESHQGWAVLQEAVSTGDPEMVQLVLQYRDFQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFRGQEAGALVMEVDHDRQVVHTETLGPALHEPEALLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKLRNKGGKTPFQSFLGMAQQHSSHSGAPVQQAASPTNPTAISPEEYFDPSFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPVSSVWVPAPSSAISAPGSPFPCEVDPTVFEVPEGYSVLGAERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGILPPPQVTVFEEQLQLEQALQESLQLSTESRAPESPQRTPPSPVPPSFEEQLRLALELSSREQEEQERRGQQEEEDLQRILRLSLTEH", "length": 605 }, "evidence": [ { "id": "F1N2K0", "url": "https://omabrowser.org/oma/group/F1N2K0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZUJ7-1", "protein_name": "Ankyrin repeat domain 13D", "gene_name": "Ankrd13d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGLGPTFPLHRLVWANRHRELEAALHSRKHDIEQEDPRGRTPLELAVTLGNLESVRVLLRHNANVGKESHQGWAVLQEAVSTGDPEMVQLVLQYRDFQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMAWQRGRRSFIFRGQEAGALVMEVDHDRQVVHTETLGPALHEPEVLLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKLRNKGGKTPFQSFLGMAQQHSSHTAAPVQQAASPTNPTAISAEEYFDPSFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPVSSVCVPKPSSAISASGSPFPCEVDPTVFEVPEGYSVLGAERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGIHPPPRVTVFEEQLQLEQALQESLQLSTESRGPESPQKTPPPPAPPSFEEQLRLALELSSREQEELERRGQQEEEDLQRILQLSLTEH", "length": 605 }, "evidence": [ { "id": "F1N2K0", "url": "https://omabrowser.org/oma/group/F1N2K0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RUX4-1", "protein_name": "Ankyrin repeat domain 13D", "gene_name": "ANKRD13D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGPGPTFPLHRLVWANRHRELEAALHSRQHDIEQEDPRGRTPLELAVSLGNLESVRVLLRHNANVGKESCQGWAVLQEAVSTGDPEMVQLVLQYRDYQRATQRLAGIPELLHKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFKGQEVGALVMEVDHDRQVVHTETLGLALHEPEALLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKSRSKGGKTPFQSFLGMAQQHSSHNGAPVQQAASPTNPTAISPDEYFDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFGNLCGCDEPLSSVWAPAPGSAVAASGSPFPCEVDPAVFEVPEGYSVLGTERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALSNTRPGTHLPQGTAFEEQLQLERALQESLRMSTETGGPGSPHRTPPALAPPSFEEQLRLALELSSREQEERERRGQQEEEDLQRILQLSLTEH", "length": 604 }, "evidence": [ { "id": "F1N2K0", "url": "https://omabrowser.org/oma/group/F1N2K0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4J6I7-1", "protein_name": "Ankyrin repeat family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MENVDVSKYIHSSVHKAVASKDYVGLRAILSSLPKPKDPCEIQTEAASLSEEAKSDTISAVIDRRDVPSRDTPLHLAVKLCDSTSVEMLMVAGADWTLQNEDGWNALQEAVCSRQEAIAMIIVRHYQPLAWAKWCRRLPRLIATMSKMKDFYLEMSFHFESSVVPFVSKVAPSDTYKVWKVGSNLRADMTMAGFDGFKIQRSDQSILFLGDGSEDGEVARGSLYMVNHKDKEVMNALDGACGVPSEEEVRKEVAAMCKSNIFRPGIDVTQAVLSPQTNWRRQEKSEMVGPWKAKVYEMNNVVVSVKSRKVPGSLAVEGGDDDICDVLTDEEQKQLEDALKLDLPDFPNVNGENGFIVHHQEDHVEANKKAEKKGWLGGWRKKETKQEKQIQYAPPRSSLCVNEKVSNLLGESNQIKPGRHSVDNEHYRKPKALVSDKTRHESEYKKGLRPVLWLSPNFPLQTEELLPLLDILANKVKAIRRLRELLTTKLPSGTFPVKVAIPVVPTIKVLVTFTKFEEIEPVDEFKTPLSSPTSSGYESPAAATTDFTNSSSSSSWFRRSRSNKDGGSSKSKTLQDPFAIPTGYTWVSLESKKRKPKKGGKKTEQVS", "length": 607 }, "evidence": [ { "id": "F1N2K0", "url": "https://omabrowser.org/oma/group/F1N2K0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q6PD24-1", "protein_name": "Ankyrin repeat domain-containing protein 13D", "gene_name": "Ankrd13d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGLGPTFPLHRLVWANRHRELEAALHSRKHDIEQEDPQGRTPLELAVTLGNLESVRVLLRHNANVGKESHQGWAVLQEAVSTGDPEMVQLVLQYRDFQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFRGQEAGALVMEVDHDRQVVHTETLAPALHEPEALLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMESVSGYEAKVYSATNVELVTRTRTEHLSDQDKLRNKGGKTPFQSFLGMAQQHSSHTLAPVQQAASPTNPTAISAEEYFDPSFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPVSSVCVPNSSSAISASGSPFPCEVDPTVFEVPEGYSVLGAERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGIHPPPRVTVFEEQLQLEQALQESLQLSTESRGPESPQKTPPSPAPPSFEEQLRLALELSSREQEELERRGQQEEDDLQRILQLSLTEH", "length": 605 }, "evidence": [ { "id": "F1N2K0", "url": "https://omabrowser.org/oma/group/F1N2K0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZTN6-3", "protein_name": "Ankyrin repeat domain-containing protein 13D", "gene_name": "ANKRD13D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPGPTFPLHRLVWANRHRELEAALHSHQHDIEQEDPRGRTPLELAVSLGNLESVRVLLRHNANVGKENRQGWAVLQEAVSTGDPEMVQLVLQYRDYQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFKGQEAGALVMEVDHDRQVVHVETLGLTLQEPETLLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKSRSKAGKTPFQSFLGMAQQHSSHTGAPVQQAASPTNPTAISPEEYFDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPLSSVWVPAPSSAVAASGNPFPCEVDPTVFEVPNGYSVLGMERNEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGARPPPQATVYEEQLQLERALQESLQLSTEPRGPGSPPRTPPAPGPPSFEEQLRLALELSSREQEERERRGQQEEEDLQRILQLSLTEH", "length": 605 }, "evidence": [ { "id": "F1N2K0", "url": "https://omabrowser.org/oma/group/F1N2K0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-modified protein reader activity", "id": "GO:0140036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140036", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of receptor internalization", "id": "GO:0002091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002091", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "pmid": "" }, { "name": "regulation of receptor-mediated endocytosis", "id": "GO:0048259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048259", "evidence": [ { "database": "UniProtKB", "id": "F1N2K0", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2K0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 604, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2K0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2K0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2K0" }, { "id": "PF11904", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11904" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ankyrin repeat", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 469, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 558 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 338, "end_pos": 340 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2L8-1", "uniprot_ac": "F1N2L8", "uniprot_id": "F1N2L8_BOVIN", "mass": { "chemical_mass": 39668.0, "monoisotopic_mass": 39668.0 }, "refseq": {}, "gene_names": [ { "name": "PTGER2", "type": "recommended", "evidence": [ { "id": "F1N2L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ] } ], "protein_names": [ { "name": "Prostaglandin E2 receptor EP2 subtype", "type": "recommended", "evidence": [ { "id": "F1N2L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2L8/entry#names_and_taxonomy" } ] }, { "name": "Prostanoid EP2 receptor", "type": "synonym", "evidence": [ { "id": "F1N2L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2L8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8#function" }, { "database": "UniProtKB", "id": "ARBA00055790", "url": "https://www.uniprot.org/uniprotkb/ARBA00055790#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTGER2", "url": "https://www.uniprot.org/uniprotkb/F1N2L8", "locus": { "chromosome": "10", "start_pos": 11826449, "end_pos": 11838823, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002163", "url": "https://www.ensembl.org/id/ENSBTAG00000002163" } ] } } ], "crossref": [ { "id": "F1N2L8", "url": "https://alphafold.ebi.ac.uk/entry/F1N2L8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002163", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002163", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15139", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15139", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CSVSPFV", "url": "https://omabrowser.org/oma/group/CSVSPFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2L8", "url": "https://www.orthodb.org/?gene=F1N2L8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11866", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11866", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11866:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11866:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-391908", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391908", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2L8-1", "url": "https://www.uniprot.org/uniprotkb/F1N2L8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTSNDSQSENREEPLWLPSGESPAISSVMFTAGVLGNLIALALLVRRWRGDSGRSEGRGNSISLFHVLVTELVLTDLLGTCLISPVVLASYAQNRTLVALGPERRVCTYFAFSMTFFSLATMLMLFAMALERYLAIGHPYFYQRRVTRRSGLAVLPTIYIVSLLFCSLPLLDHWKYAQYNPGTWCFIGHKQTTYLRLYATLLLLLIIAVLACNFSVIVNLIHMHRRGRRSRCGPSLGSSHRRAERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNENSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRVSLRTQEATQTSCSTQSNASKQIDL", "length": 352, "header": "tr|F1N2L8-1|F1N2L8_BOVIN Isoform 1 of Prostaglandin E2 receptor EP2 subtype OS=Bos taurus OX=9913 GN=PTGER2 PE=3 SV=1 CANONICAL=F1N2L8-1" }, "isoforms": [ { "isoform_ac": "F1N2L8-1", "url": "https://www.uniprot.org/uniprotkb/F1N2L8/entry", "sequence": { "sequence": "MGNTSNDSQSENREEPLWLPSGESPAISSVMFTAGVLGNLIALALLVRRWRGDSGRSEGRGNSISLFHVLVTELVLTDLLGTCLISPVVLASYAQNRTLVALGPERRVCTYFAFSMTFFSLATMLMLFAMALERYLAIGHPYFYQRRVTRRSGLAVLPTIYIVSLLFCSLPLLDHWKYAQYNPGTWCFIGHKQTTYLRLYATLLLLLIIAVLACNFSVIVNLIHMHRRGRRSRCGPSLGSSHRRAERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNENSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRVSLRTQEATQTSCSTQSNASKQIDL", "length": 352, "header": "tr|F1N2L8-1|F1N2L8_BOVIN Isoform 1 of Prostaglandin E2 receptor EP2 subtype OS=Bos taurus OX=9913 GN=PTGER2 PE=3 SV=1 CANONICAL=F1N2L8-1" }, "locus": { "chromosome": "10", "start_pos": 11838818, "end_pos": 11827869, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002800.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002800.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002800.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002800.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-391908", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391908", "resource": "Reactome", "description": "Prostanoid ligand receptors" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7IK67-1", "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "Ptger2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHNASNDSVRVEDCESRQWLPSGESPAISSVMFSAGVVGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYARNQTLVALAPKSRVCTYFAFTMTFFSLATMLMLFAMALERYLSIGHPYFYRRRFSRRGGLAVLPAIYAVSLLFCSLPLLNYGEYVQYCPGTWCFIRHGRTAYLQLYATVLLLLILAVLACNFSVILNLVRMHRRSKRSRCGSSSGGPGGPGSRRRGERTSMAEEADHLILLAIMTITFAICSLPFTIFAYMNETSSRKEKLDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCFRTSVRTQEASRTSCSTQSSSSKQTDLCGQL", "length": 362 }, "evidence": [ { "id": "F1N2L8", "url": "https://omabrowser.org/oma/group/F1N2L8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NDL3-1", "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "PTGER2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNGTGREPCGHGEALAAGARPLVSALMFSAGLLGNLLALGLLLRCRRPPRARPPSLFHVLVLALVVTDLLGTCSVSPFVLASYHRNLTLTALGRGGHICLYFGFAMSFFGLATMLVLFAMALERCLALGRPYFYERFLSPRAGLVALPAIYTFSAAFCSLPLLGFGRYVQYCPGTWCFIQMRVDDGRHKAAGLHVTFSLLYATLLLFLILSVLLCNLSVIANLARMRRRGQRTRRLATLEQPRGVGGSGRRIFSMAEEIDHLLLLAIMTITFVICSLPFTICAYVNKFSQSENHDWDLLALRFLSINPIIDPWVFAILRPPVLRVLRSVLCCQLSPGRQDSQCPTSAKTKLEPSGQ", "length": 356 }, "evidence": [ { "id": "F1N2L8", "url": "https://omabrowser.org/oma/group/F1N2L8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P43116-1", "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "PTGER2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL", "length": 358 }, "evidence": [ { "id": "F1N2L8", "url": "https://omabrowser.org/oma/group/F1N2L8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5RI92-1", "protein_name": "Prostaglandin E receptor 2b subtype EP2", "gene_name": "ptger2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASQNVSCREQISVSGGSPTIPAFMFSTGVLGNVVALILLEMRRRKQPASLFHVLVSSLVITDLLGTFSLSPLVLTAYFRNASLLGMNENRLACGHFAYAMTFFSVVTLAILLSMAVERWLSIGHPFFYEKYSSKRCGYITIALIYLLCALFCVTPFLGFGKYVQYCPGTWCFIDMDPSASEHKAFNIIYASCLLLMIVCTVLCNASVIYHISRMYRRLKAHRSSVRRQRGHKRHRSMTKEVEHLVLLWFMTIAFVFCSLPLVIQVYHNTLYHRDRHRNNVIPLLFLSANPIIDPWVFIILSPPVPRLLWDKICKAAKSKPIREKVHSIHPVLYHSSPPAD", "length": 341 }, "evidence": [ { "id": "F1N2L8", "url": "https://omabrowser.org/oma/group/F1N2L8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q62053-1", "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "Ptger2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESHACTYFAFTMTFFSLATMLMLFAMALERYLSIGYPYFYRRHLSRRGGLAVLPVIYGASLLFCSLPLLNYGEYVQYCPGTWCFIRHGRTAYLQLYATMLLLLIVAVLACNISVILNLIRMHRRSRRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAICSLPFTIFAYMDETSSLKEKWDLRALRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRTSLRTQEAQQTSCSTQSSASKQTDLCGQL", "length": 362 }, "evidence": [ { "id": "F1N2L8", "url": "https://omabrowser.org/oma/group/F1N2L8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q62928-1", "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "Ptger2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL", "length": 357 }, "evidence": [ { "id": "F1N2L8", "url": "https://omabrowser.org/oma/group/F1N2L8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "pmid": "" }, { "name": "positive regulation of cytosolic calcium ion concentration", "id": "GO:0007204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007204", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "pmid": "" }, { "name": "cellular response to prostaglandin E stimulus", "id": "GO:0071380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071380", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "prostaglandin E receptor activity", "id": "GO:0004957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004957", "evidence": [ { "database": "UniProtKB", "id": "F1N2L8", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2L8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 352, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2L8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2L8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2L8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 309, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 6, "end_pos": 8 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2S7-1", "uniprot_ac": "F1N2S7", "uniprot_id": "F1N2S7_BOVIN", "mass": { "chemical_mass": 30211.0, "monoisotopic_mass": 30211.0 }, "refseq": { "ac": "XP_002688564", "name": "testis-specific serine/threonine-protein kinase 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688564" }, "gene_names": [ { "name": "TSSK6", "type": "recommended", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "name": "TSSK6", "type": "synonym", "evidence": [ { "id": "XP_002688564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688564" } ] } ], "protein_names": [ { "name": "Testis-specific serine/threonine-protein kinase 6", "type": "recommended", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7/entry#names_and_taxonomy" } ] }, { "name": "Serine/threonine-protein kinase SSTK", "type": "synonym", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7/entry#names_and_taxonomy" } ] }, { "name": "Small serine/threonine kinase", "type": "synonym", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7/entry#names_and_taxonomy" } ] }, { "name": "testis-specific serine/threonine-protein kinase 6", "type": "synonym", "evidence": [ { "id": "XP_002688564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688564" } ] } ], "function": [ { "annotation": "Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules. May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins. Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7#function" }, { "database": "UniProtKB", "id": "ARBA00053629", "url": "https://www.uniprot.org/uniprotkb/ARBA00053629#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSSK6", "url": "https://www.uniprot.org/uniprotkb/F1N2S7", "locus": { "chromosome": "7", "start_pos": 3811969, "end_pos": 3809608, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006649", "url": "https://www.ensembl.org/id/ENSBTAG00000006649" } ] } } ], "crossref": [ { "id": "F1N2S7", "url": "https://alphafold.ebi.ac.uk/entry/F1N2S7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006649", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006649", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14164", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14164", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539707", "url": "https://www.ncbi.nlm.nih.gov/gene/539707", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539707", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539707", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FELIEVC", "url": "https://omabrowser.org/oma/group/FELIEVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2S7", "url": "https://www.orthodb.org/?gene=F1N2S7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346:SF102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346:SF102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688564", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688564", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S7-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGGQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPDGLELSERCKALIAELLQFSPSARPSAGQVARNGWLRAGDSG", "length": 273, "header": "tr|F1N2S7-1|F1N2S7_BOVIN Isoform 1 of Testis-specific serine/threonine-protein kinase 6 OS=Bos taurus OX=9913 GN=TSSK6 PE=1 SV=2 CANONICAL=F1N2S7-1" }, "isoforms": [ { "isoform_ac": "F1N2S7-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S7/entry", "sequence": { "sequence": "MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGGQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPDGLELSERCKALIAELLQFSPSARPSAGQVARNGWLRAGDSG", "length": 273, "header": "tr|F1N2S7-1|F1N2S7_BOVIN Isoform 1 of Testis-specific serine/threonine-protein kinase 6 OS=Bos taurus OX=9913 GN=TSSK6 PE=1 SV=2 CANONICAL=F1N2S7-1" }, "locus": { "chromosome": "7", "start_pos": 3811498, "end_pos": 3810680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008738.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008738.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045962.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045962.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] }, { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:539707", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539707", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YTI1-1", "protein_name": "Testis-specific serine/threonine-protein kinase 6", "gene_name": "TSSK6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKISAGEKVLNELGYKLGQTLGEGSFSKVKAATSTKHKDTLAIKVVDRRRAPPAFVYKFLPRELSILRRIRHPNIVHIFELIEVCDGKLYIVMEAAATDLLQLVQKMGKMPCVPEARDIFAQIVGAVRYLHDRNLVHRDLKCENVLLTADGRRAKLTDFGFSKEVNVYPDLCTTFCGSAAYASPEVLMGIPYDGKKSDMWSLGVMFFVMVTGCMPFNDTHVRSLPQQQKKGVLYPEGVLPLPEHCQALIAQLLNYSAERRPGAGQVAKNCWLKGDI", "length": 277 }, "evidence": [ { "id": "F1N2S7", "url": "https://omabrowser.org/oma/group/F1N2S7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZEK4-1", "protein_name": "Testis-specific serine/threonine-protein kinase 6", "gene_name": "Tssk6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGSQARELFSQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPDGLELSERCKSLIAELLQFSPSARPSAGQVARNGWLRAGDSG", "length": 273 }, "evidence": [ { "id": "F1N2S7", "url": "https://omabrowser.org/oma/group/F1N2S7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S6Q0-1", "protein_name": "Testis-specific serine/threonine-protein kinase 6", "gene_name": "TSSK6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGGQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPDGLELSERCKALIAELLQFSPSARPSAGQVARNGWLRAGDSG", "length": 273 }, "evidence": [ { "id": "F1N2S7", "url": "https://omabrowser.org/oma/group/F1N2S7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q925K9-1", "protein_name": "Testis-specific serine/threonine-protein kinase 6", "gene_name": "Tssk6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGSQARELFSQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKITDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSLGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPDGLELSERCKSLIAELLQFSPSARPSAGQVARNGWLRAGDSG", "length": 273 }, "evidence": [ { "id": "F1N2S7", "url": "https://omabrowser.org/oma/group/F1N2S7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BXA6-1", "protein_name": "Testis-specific serine/threonine-protein kinase 6", "gene_name": "TSSK6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG", "length": 273 }, "evidence": [ { "id": "F1N2S7", "url": "https://omabrowser.org/oma/group/F1N2S7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "axonemal microtubule doublet inner sheath", "id": "GO:0160110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160110", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" }, { "name": "sperm DNA condensation", "id": "GO:0035092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035092", "evidence": [ { "database": "UniProtKB", "id": "F1N2S7", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2S7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 273, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2S7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2S7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 267, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2T3-1", "uniprot_ac": "F1N2T3", "uniprot_id": "F1N2T3_BOVIN", "mass": { "chemical_mass": 72469.0, "monoisotopic_mass": 72469.0 }, "refseq": {}, "gene_names": [ { "name": "CPZ", "type": "recommended", "evidence": [ { "id": "F1N2T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ] } ], "protein_names": [ { "name": "Carboxypeptidase Z", "type": "recommended", "evidence": [ { "id": "F1N2T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2T3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Specifically cleaves substrates and peptides with C-terminal basic amino acids, especially those containing C-terminal Arg residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSP9#function" }, { "database": "UniProtKB", "id": "ARBA00094247", "url": "https://www.uniprot.org/uniprotkb/ARBA00094247#function" }, { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPZ", "url": "https://www.uniprot.org/uniprotkb/F1N2T3", "locus": { "chromosome": "6", "start_pos": 114815408, "end_pos": 114791913, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014803", "url": "https://www.ensembl.org/id/ENSBTAG00000014803" } ] } } ], "crossref": [ { "id": "F1N2T3", "url": "https://alphafold.ebi.ac.uk/entry/F1N2T3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03867", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03867", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11308", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11308", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537837", "url": "https://www.ncbi.nlm.nih.gov/gene/537837", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DCGRYFA", "url": "https://omabrowser.org/oma/group/DCGRYFA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSP9", "url": "https://www.orthodb.org/?gene=A0A3Q1LSP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2T3", "url": "https://www.orthodb.org/?gene=F1N2T3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11532", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11532", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11532:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11532:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LSP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2T3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2T3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPPPPLLLTMLVLAAARPGCEPAWDPEGGCPRSAAADSAMCVDLQLQTCSDVTYNRTAFPTLLQHRSREAVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYDPLEKLRGGLDIEEALPSGHPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDDKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCMKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIPARMKRAGRVDFILQPLRTGPQKFLPGSRRGGLGGEPQEPDEEPLGARRQPTTGGSKPWWWSYFTSLGQHQPRWLLKY", "length": 644, "header": "tr|F1N2T3-1|F1N2T3_BOVIN Isoform 1 of Carboxypeptidase Z OS=Bos taurus OX=9913 GN=CPZ PE=3 SV=1 CANONICAL=F1N2T3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSP9/entry", "sequence": { "sequence": "MRPPPPLLLTMLVLAAARPGCEPAWDPEAMCVDLQLQTCSDVTYNRTAFPTLLQHRSREAVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYDPLEKLRGGLDIEEALPSGHPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDDKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCMKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIPARMKRAGRVDFILQPLRTGPQKFLPGSRRGGLGGEPQEPDEEPLGARRQPTTGGSKPWWWSYFTSLGQHQPRWLLKY", "length": 633, "header": "tr|A0A3Q1LSP9-1|A0A3Q1LSP9_BOVIN Computationally mapped isoform of Carboxypeptidase Z OS=Bos taurus OX=9913 GN=CPZ PE=3 SV=1 CANONICAL=F1N2T3-1" }, "locus": { "chromosome": "6", "start_pos": 114815291, "end_pos": 114792016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077386.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077386.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063418.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063418.1" } ] } }, { "isoform_ac": "F1N2T3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2T3/entry", "sequence": { "sequence": "MRPPPPLLLTMLVLAAARPGCEPAWDPEGGCPRSAAADSAMCVDLQLQTCSDVTYNRTAFPTLLQHRSREAVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYDPLEKLRGGLDIEEALPSGHPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDDKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCMKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIPARMKRAGRVDFILQPLRTGPQKFLPGSRRGGLGGEPQEPDEEPLGARRQPTTGGSKPWWWSYFTSLGQHQPRWLLKY", "length": 644, "header": "tr|F1N2T3-1|F1N2T3_BOVIN Isoform 1 of Carboxypeptidase Z OS=Bos taurus OX=9913 GN=CPZ PE=3 SV=1 CANONICAL=F1N2T3-1" }, "locus": { "chromosome": "6", "start_pos": 114815291, "end_pos": 114792016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019695.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019695.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019695.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019695.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 404, "start_aa": "Thr", "end_pos": 404, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr404", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287ARI3-1", "protein_name": "Carboxypeptidase Z", "gene_name": "CPZ", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPPPPLLLLLAALVLAAARPGCEPAWDPAGGCPRLAAVDSATCVDLQLRTCSDAAYNQTAFPTLLEHRSREVVESSSEYVLLSVLHHLLEGQCNPDLRLLGCAVLAPRCQGGQVRRPCRHVCEGLREACQPAFDAIDMAWPYFLDCGRYFASQQEGCYDPLEKLRGGLDEEEALPSGHPATFIHFTHHSYAQMVRVLKRTAARCAHIAKTYSIGRSFDGRELLVLELSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGNDRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRTASARGARSDHIAIPQHYWWGKVAPETKAIMKWMRAVPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTLWQHNKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGSHIVIAQAPGYSKVIKKVTIPARMKRAGRVDFILQPLGTGPKNFLLGPRRNGPGGAGPHGEPEEPGQEPLGARRLPEASGSKPWWWSYFRSLGQHQPRWLLKY", "length": 650 }, "evidence": [ { "id": "F1N2T3", "url": "https://omabrowser.org/oma/group/F1N2T3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YZE2-1", "protein_name": "Carboxypeptidase Z", "gene_name": "CPZ", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVPSLLLLLTGLFRATEPAPRCETGQETLGQCQTAQKAKCVDISLSSCTDVTYTQTMYPNFLDQKSREVIEYSSEYILISVLHNLLQGECNPDLRLLGCSVLAPQCEKDKVIKPCRHVCENLKKNCLSAFDAIDMAWPYFLDCDRFFAGEEEGCFDPLAKLRGEVAVEEDLPSDFPATFIQFKHHSYSQMVSTLKKTASRCSHIATTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHIPIPQSYWWGKVAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKEFSPTPDEKMFKMLAKAYADAHPVISDRSEHRCGGNFVKRGGIINGAEWYSFTGGMADFNYLHTNCFEVTVEVGCEKFPLEEELFTIWHENRDALLNYMEMVHRGIKGIVSDKFGNPIKNARISVRGIQHDITTAADGDYWRLLPPGTYIVTAQAMGYTKVMKRVTLPIKMKRAGRVDFVLRPIEIWPNKLLRRPMEDMYDQYDPLELFDPHAQHAQARGGSQQVREKPWWWSYFSSLDLHKPLWLLKQH", "length": 647 }, "evidence": [ { "id": "F1N2T3", "url": "https://omabrowser.org/oma/group/F1N2T3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O54858-1", "protein_name": "Carboxypeptidase Z", "gene_name": "Cpz", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTTPLLLAALAALAALAVAAYPSCSPGPDPSGKCQRLASTHSATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVEASPEYTLLGVLHFLLEGQCNPDLRLLGCSVLAPRCQGGHTQRPCRRVCEGLREACQPAFDAIDMAWPYFLDCTQYFAPEEEGCYDPLEQLRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKHPHEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQHNKEPLLNFLEMVHRGIKGVVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMKRVTIPLRMKRAGRVDFILQPLGTGPKNFLPGPSRALPRSLDPQGAPAQLDFEPPRARRQPASGSKPWWWAYFTSLSPHKPRWLLKY", "length": 652 }, "evidence": [ { "id": "F1N2T3", "url": "https://omabrowser.org/oma/group/F1N2T3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q66K79-1", "protein_name": "Carboxypeptidase Z", "gene_name": "CPZ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY", "length": 652 }, "evidence": [ { "id": "F1N2T3", "url": "https://omabrowser.org/oma/group/F1N2T3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R4V4-1", "protein_name": "Carboxypeptidase Z", "gene_name": "Cpz", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTMPLLLAALAALAVLALAARPSPSCSPGPDPSGKCQRLVYTHSATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVESSPEYMLLGVIHFLLEGQCNPDLRLLGCSVLAPRCEGGHTQRPCRHVCEGLREACQPAFDAIDMAWPYFLDCAQYFAPEEEGCYDPLEELRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREVLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKNPHEKKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQQNKEPLLNFLEMVHRGIKGMVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMKRVTIPLRMKKAGRVDFILHPLATGPKNFLPGPSRALPRFQDPQREPTQMDFEPPRARRQPASGSKPWWWAYFTSLSPYKPRWLLKY", "length": 654 }, "evidence": [ { "id": "F1N2T3", "url": "https://omabrowser.org/oma/group/F1N2T3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" }, { "name": "metallocarboxypeptidase activity", "id": "GO:0004181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" }, { "name": "peptide metabolic process", "id": "GO:0006518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006518", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N2T3", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2T3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 644, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2T3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2T3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" }, { "id": "PS50038", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FZ", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 159, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N2T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2T3" }, { "id": "PS52035", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M14", "eco_id": "ECO_0000259", "start_pos": 185, "end_pos": 501, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 404 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 280, "end_pos": 282 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2W6-1", "uniprot_ac": "F1N2W6", "uniprot_id": "F1N2W6_BOVIN", "mass": { "chemical_mass": 64396.0, "monoisotopic_mass": 64396.0 }, "refseq": { "ac": "XP_002691535", "name": "UMP-CMP kinase 2, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691535" }, "gene_names": [ { "name": "CMPK2", "type": "recommended", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ] }, { "name": "CMPK2", "type": "synonym", "evidence": [ { "id": "XP_002691535", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691535" } ] } ], "protein_names": [ { "name": "UMP-CMP kinase 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6/entry#names_and_taxonomy" } ] }, { "name": "2.7.4.14", "type": "synonym", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6/entry#names_and_taxonomy" } ] }, { "name": "Nucleoside-diphosphate kinase", "type": "synonym", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6/entry#names_and_taxonomy" } ] }, { "name": "UMP-CMP kinase 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "XP_002691535", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691535" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CMPK2", "url": "https://www.uniprot.org/uniprotkb/F1N2W6", "locus": { "chromosome": "11", "start_pos": 90084513, "end_pos": 90068126, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019979", "url": "https://www.ensembl.org/id/ENSBTAG00000019979" } ] } } ], "crossref": [ { "id": "F1N2W6", "url": "https://alphafold.ebi.ac.uk/entry/F1N2W6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019979", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019979", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "784304", "url": "https://www.ncbi.nlm.nih.gov/gene/784304", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784304", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784304", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECTSLIP", "url": "https://omabrowser.org/oma/group/ECTSLIP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2W6", "url": "https://www.orthodb.org/?gene=F1N2W6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10344:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10344:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02223", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02223", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691535", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691535", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11600", "url": "https://www.rhea-db.org/rhea/11600", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "18113", "url": "https://www.rhea-db.org/rhea/18113", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25094", "url": "https://www.rhea-db.org/rhea/25094", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44640", "url": "https://www.rhea-db.org/rhea/44640", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2W6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2W6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRYTRARAHARVPYPGTSNTGGIIQPGAWGHRPASHRGSLSEAARRPGLCGCPSGPSWRQPARGATSRSGGGGGETEEVAPTRAPPTSRRRRRRRRRRRRRRRFVFVSTGVPPAGSQVSFPQRPGRHREAPMTFGRHPRARRLLARLSGRRRGACARAMEPPRCFALELPGCTLAHFAVGELAPGARPDPRVAALLGPPGRSYSLSVPETGGVGARVRAARLHQHLRQQLRRGPFQRCELRRLLGYRPDGGAGALQHGFLLRDPRDSPDTRQALLELLDACPEAPRPLLAEFSGDRLCQLWQRPWERRDGRGWRQLGGERVGPAPEPALHPVVPDLPSAGVFPHREAACAVLEACTSFIPEAREVLDLVDQCPEQVQKGRFPVIVIEGLDATGKTTVTQSVSDSLKAVLLKSPPSCISQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESTKSPVVVDRYWHSTATYAIATEVSGGLQHLPPIHHPIYQWPRDLLKPDLILLLTVSPEERMQRIEGRGMEKTREEAELETNSIFRQKVEVCYQRMENPGCHVVDASPSREKVLQMVLSVIQNNCNYL", "length": 579, "header": "tr|F1N2W6-1|F1N2W6_BOVIN Isoform 1 of UMP-CMP kinase 2, mitochondrial OS=Bos taurus OX=9913 GN=CMPK2 PE=3 SV=3 CANONICAL=F1N2W6-1" }, "isoforms": [ { "isoform_ac": "F1N2W6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2W6/entry", "sequence": { "sequence": "MKRYTRARAHARVPYPGTSNTGGIIQPGAWGHRPASHRGSLSEAARRPGLCGCPSGPSWRQPARGATSRSGGGGGETEEVAPTRAPPTSRRRRRRRRRRRRRRRFVFVSTGVPPAGSQVSFPQRPGRHREAPMTFGRHPRARRLLARLSGRRRGACARAMEPPRCFALELPGCTLAHFAVGELAPGARPDPRVAALLGPPGRSYSLSVPETGGVGARVRAARLHQHLRQQLRRGPFQRCELRRLLGYRPDGGAGALQHGFLLRDPRDSPDTRQALLELLDACPEAPRPLLAEFSGDRLCQLWQRPWERRDGRGWRQLGGERVGPAPEPALHPVVPDLPSAGVFPHREAACAVLEACTSFIPEAREVLDLVDQCPEQVQKGRFPVIVIEGLDATGKTTVTQSVSDSLKAVLLKSPPSCISQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESTKSPVVVDRYWHSTATYAIATEVSGGLQHLPPIHHPIYQWPRDLLKPDLILLLTVSPEERMQRIEGRGMEKTREEAELETNSIFRQKVEVCYQRMENPGCHVVDASPSREKVLQMVLSVIQNNCNYL", "length": 579, "header": "tr|F1N2W6-1|F1N2W6_BOVIN Isoform 1 of UMP-CMP kinase 2, mitochondrial OS=Bos taurus OX=9913 GN=CMPK2 PE=3 SV=3 CANONICAL=F1N2W6-1" }, "locus": { "chromosome": "11", "start_pos": 90083509, "end_pos": 90068325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026613.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026613.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026613.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026613.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:784304", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784304", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RG89-1", "protein_name": "UMP-CMP kinase 2, mitochondrial", "gene_name": "CMPK2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFGRRPRAPLLLARLSGLRRGACAPAMELPRCFALELPGCTLAHFAVDDEAPGAHPDPHAAALLGPPGRSYSLSVPVAEGAGCAARVRAARLHQRLLHQLRGSPFQLCQLHRLLCYHPGGGAGGLQHGFLLHDPRDSPDTRSALLALLDAYRDAPRPLLAEFAGDAGRQLWRRPWELQDEHGWRQVGSELVVPAPDPALHPVVPDLPSCGVFPHREAARAVLEACTSFIPEAQAVLDLVDRCPEQVQKGKFPVIAIEGLDATGKTTVTQSVSDSLKAVLLKSPPACISQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESTKSPVIIDRYWHSTATYTIASEVSGGLQHLPPTHHPIYQWPRDLLKPDLVLLLTVSPEERMKRIEGRGLERTREEVELETDSIYRQKVEVSYQRMEDPGCHVVDASPSREKVLQTVLSIIQNNCNVL", "length": 449 }, "evidence": [ { "id": "F1N2W6", "url": "https://omabrowser.org/oma/group/F1N2W6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZC63-1", "protein_name": "UMP-CMP kinase 2, mitochondrial", "gene_name": "Cmpk2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALISCPRAPLWLGRLSRRLCARHRACTGTMARPRRFTVELPDCSLTHFVLGDAAGHRDARLTELLGPPGRSYALCVPLVPGEGCGPRVQAARVYQRLQLQLRQGPLQRCELSKLLGYGPGDQASEAQHGFLLRDPSDHPDTRQDLLQLLGSCQEATRLHLAEFQADSQGLLWQRLWELQGDRQVQVDCACVLPAPEPHLHPLLPDLLNSAVFQDRDAARAVLEECTSFIPEAREVLDLVDQCPREIQKGKFQVIAIEGLDATGKTTLTQSVSESLQAVLLQSPPPCISQWRKLFDDEPTIIRRAFYSLGNYLVASEIAKQSAKFPVIVDRYWHSTATYAIATEVSGGLQYLPPAHHPVYQWPRDLLKPDLVLLLTVNSEERVRRLQGRGQEKTKEEAELEVNSVFRQKVEATYQRMENPSCRLVDASPSRETVLQTVLQLIQRAGH", "length": 447 }, "evidence": [ { "id": "F1N2W6", "url": "https://omabrowser.org/oma/group/F1N2W6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3U5Q7-1", "protein_name": "UMP-CMP kinase 2, mitochondrial", "gene_name": "Cmpk2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALISRPRAPLWLGRLSRRLCGRHQACMGTMARPRRFTVELPDCSLTHFVLGDATDHRDARLAELLGPPGRSYALCVPLAPGEGCGPRVQAARVHHRLLQQLRRGPLQRCQLSKLLGYGPGDQAGEAQHGFLLRDPCDHPDTRRDLLQLLGSCQEAARPQLAEFQADSQGLLWQRLWELQGDRQVQVDCACVLPAQEPHLHPLLPDLLNSAVFQDRDAARAVLEECTSFIPEARAVLDLVDQCPKEVQKGKFQVIAIEGLDATGKTTLTQSVSESLKAVLLQSPPPCISQWRKIFDDEPTIIRRAFYSLGNYLVASEIAKESTNFPVIVDRYWHSTATYAIATEVSGGLQYLPPAHHPVYQWPGDLLKPDLVLLLTVNSEERVRRLQGRGQEKTKEEAELEANNVFRQKVEMTYQRMENPSCHLVDASPSRETVLQKVLELIQSSGR", "length": 447 }, "evidence": [ { "id": "F1N2W6", "url": "https://omabrowser.org/oma/group/F1N2W6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5EBM0-1", "protein_name": "UMP-CMP kinase 2, mitochondrial", "gene_name": "CMPK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFARRLLRGPLSGPLLGRRGVCAGAMAPPRRFVLELPDCTLAHFALGADAPGDADAPDPRLAALLGPPERSYSLCVPVTPDAGCGARVRAARLHQRLLHQLRRGPFQRCQLLRLLCYCPGGQAGGAQQGFLLRDPLDDPDTRQALLELLGACQEAPRPHLGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVPEPPLHPVVPDLPSSVVFPDREAARAVLEECTSFIPEARAVLDLVDQCPKQIQKGKFQVVAIEGLDATGKTTVTQSVADSLKAVLLKSPPSCIGQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESAKSPVIVDRYWHSTATYAIATEVSGGLQHLPPAHHPVYQWPEDLLKPDLILLLTVSPEERLQRLQGRGMEKTREEAELEANSVFRQKVEMSYQRMENPGCHVVDASPSREKVLQTVLSLIQNSFSEP", "length": 449 }, "evidence": [ { "id": "F1N2W6", "url": "https://omabrowser.org/oma/group/F1N2W6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" }, { "name": "dTMP kinase activity", "id": "GO:0004798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004798", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" }, { "name": "nucleoside diphosphate kinase activity", "id": "GO:0004550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004550", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" }, { "name": "UMP kinase activity", "id": "GO:0033862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033862", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "dTDP biosynthetic process", "id": "GO:0006233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006233", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" }, { "name": "dUDP biosynthetic process", "id": "GO:0006227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006227", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" }, { "name": "dTTP biosynthetic process", "id": "GO:0006235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006235", "evidence": [ { "database": "UniProtKB", "id": "F1N2W6", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11600", "name": "", "equation": "CMP + ATP = CDP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1N2W6-1", "F1MUF5-1" ], "evidence": [ { "id": "11600", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11600" } ] }, { "id": "18113", "name": "", "equation": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFD0-1", "Q3T0Q4-1", "A0AAF6ZEA8-1", "P00570-1", "Q2KIW9-1", "A0A3Q1LVZ0-1", "P52175-1", "Q0VCP1-1", "A0AAA9SPL6-1", "F1N2W6-1", "F1N6T4-1", "F1MUF5-1", "A0AAA9TUI5-1" ], "evidence": [ { "id": "18113", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18113" } ] }, { "id": "25094", "name": "", "equation": "dCMP + ATP = dCDP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCP1-1", "A0A3Q1LVZ0-1", "A0AAF6ZEA8-1", "Q2KIW9-1", "F1N2W6-1", "F1MUF5-1" ], "evidence": [ { "id": "25094", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25094" } ] }, { "id": "44640", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TUI5-1", "A4IFD0-1", "Q3T0Q4-1", "A0AAF6ZEA8-1", "P00570-1", "P52175-1", "Q2KIW9-1", "A0A3Q1LVZ0-1", "Q0VCP1-1", "A0AAA9SPL6-1", "F1N2W6-1", "F1N6T4-1" ], "evidence": [ { "id": "44640", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44640" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVZ0", "gene_name": "AK4", "activity": [ { "ec_number": "2.7.4.10", "activity": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] }, { "ec_number": "2.7.4.10", "activity": "", "evidence": [ { "id": "A0A3Q1LVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVZ0" } ] } ] }, { "uniprot_ac": "A0AAA9SPL6", "gene_name": "AK8", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0AAA9SPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL6" } ] } ] }, { "uniprot_ac": "A0AAA9TUI5", "gene_name": "NME6", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0AAA9TUI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI5" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0AAA9TUI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUI5" } ] } ] }, { "uniprot_ac": "A0AAF6ZEA8", "gene_name": "AK4", "activity": [ { "ec_number": "2.7.4.10", "activity": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] }, { "ec_number": "2.7.4.10", "activity": "", "evidence": [ { "id": "A0AAF6ZEA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZEA8" } ] } ] }, { "uniprot_ac": "A4IFD0", "gene_name": "Ak5", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A4IFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFD0" } ] } ] }, { "uniprot_ac": "F1MUF5", "gene_name": "AK9", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] }, { "ec_number": "2.7.4.4", "activity": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] }, { "ec_number": "2.7.4.4", "activity": "", "evidence": [ { "id": "F1MUF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUF5" } ] } ] }, { "uniprot_ac": "F1N2W6", "gene_name": "CMPK2", "activity": [ { "ec_number": "2.7.4.14", "activity": "UMP + ATP = UDP + ADP.", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ] }, { "ec_number": "2.7.4.14", "activity": "", "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" } ] } ] }, { "uniprot_ac": "F1N6T4", "gene_name": "NME4", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "F1N6T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "F1N6T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6T4" } ] } ] }, { "uniprot_ac": "P00570", "gene_name": "AK1", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.4", "activity": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] }, { "ec_number": "2.7.4.4", "activity": "", "evidence": [ { "id": "P00570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00570" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "Q0VCP1", "gene_name": "AK4", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] }, { "ec_number": "2.7.4.4", "activity": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] }, { "ec_number": "2.7.4.4", "activity": "", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q0VCP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCP1" } ] } ] }, { "uniprot_ac": "Q2KIW9", "gene_name": "CMPK1", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q2KIW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW9" } ] }, { "ec_number": "2.7.4.14", "activity": "UMP + ATP = UDP + ADP.", "evidence": [ { "id": "Q2KIW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW9" } ] }, { "ec_number": "2.7.4.14", "activity": "", "evidence": [ { "id": "Q2KIW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIW9" } ] } ] }, { "uniprot_ac": "Q3T0Q4", "gene_name": "NME2", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2W6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2W6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2W6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W6" }, { "id": "PF02223", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02223" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thymidylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 387, "end_pos": 567, "start_aa": "Ile", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.4.14", "ec_name": "UMP + ATP = UDP + ADP.", "evidence": [ { "id": "2.7.4.14", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14" }, { "id": "2.7.4.14", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.4.14" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2X8-1", "uniprot_ac": "F1N2X8", "uniprot_id": "F1N2X8_BOVIN", "mass": { "chemical_mass": 114287.0, "monoisotopic_mass": 114287.0 }, "refseq": {}, "gene_names": [ { "name": "ST18", "type": "recommended", "evidence": [ { "id": "F1N2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ] } ], "protein_names": [ { "name": "ST18 C2H2C-type zinc finger transcription factor", "type": "synonym", "evidence": [ { "id": "F1N2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2X8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ST18", "url": "https://www.uniprot.org/uniprotkb/F1N2X8", "locus": { "chromosome": "14", "start_pos": 21160208, "end_pos": 21242013, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005560", "url": "https://www.ensembl.org/id/ENSBTAG00000005560" } ] } } ], "crossref": [ { "id": "F1N2X8", "url": "https://alphafold.ebi.ac.uk/entry/F1N2X8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005560", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002515", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002515", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N2X8", "url": "https://www.orthodb.org/?gene=F1N2X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10816", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10816", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10816:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10816:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01530", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01530", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08474", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08474", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2X8-1", "url": "https://www.uniprot.org/uniprotkb/F1N2X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAEAEDKTLRTRAKGTKAPMDSLIQELSAAHDCTTAKKRRAGEQALGVPVNKRKSLLMKPRHYSPSVDCEEGRADQVEAEGQDDRLETNHHPSTEEIMIKPMDEKFHSTAQEKSDGKEDRYGCYQELVVKSLMHLGTLEKSASAQTIIENLNDSGIQSLKAEGDEVDECFMVPSDDGKDKTDNSRLRFSPSSDSDSNSESAENGWDSGSSFSEEAKPPRVPKYVLVDDRKDLLEVPEIKTEGNKFISCKNVCDSETERKDPQNTPLDPSDGPAQPSFPGSEEDGRGCPAAGTEEATALEKAKGNLSLLEQAIALQAERGCVFHNTYKELDRFLLEHLSGERRQTKVIDMGGRQVFPNKHSPRPEKRETKCPIPGCDGTGHVTGLYPHHRSLSGCPHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMSQDKSQLDSPKTGQCPEQGHRTSLVKQIEFNFRSQAITSPRATVSKEQEKFGKIPFDYASFDAQVFGKCPLVQTGRKTPPFPESKHFSSPGKFPPRLPSAGAHTQSPGRASSYGSGQRSEDTHIAAAAAILNLSTRCREAADILANRQQGLHAKGAEIEVDENGTLDLSMKKARILDKVAPLTSTNPSVPTASSSPFKTSSLLVNAAFYQALCDHEGWDTPINYSKAHGKTEEEKEKDPVSSLENLEEKKFSGEASIPSPKPKLHTRDLKKELITCPTPGCDGSGHVTGNYASHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKGGVKVTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGAPLSWKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQAIKKGKVSEELMTIKVKASGGIENDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQNNESLLKELAGLSQALISSLADIQLPQMGPISEQNFEAYVNTLTDMYSNLERDYSPECKALLESIKQAVKGIHV", "length": 1048, "header": "tr|F1N2X8-1|F1N2X8_BOVIN Isoform 1 of ST18 C2H2C-type zinc finger transcription factor OS=Bos taurus OX=9913 GN=ST18 PE=3 SV=4 CANONICAL=F1N2X8-1" }, "isoforms": [ { "isoform_ac": "F1N2X8-1", "url": "https://www.uniprot.org/uniprotkb/F1N2X8/entry", "sequence": { "sequence": "MDAEAEDKTLRTRAKGTKAPMDSLIQELSAAHDCTTAKKRRAGEQALGVPVNKRKSLLMKPRHYSPSVDCEEGRADQVEAEGQDDRLETNHHPSTEEIMIKPMDEKFHSTAQEKSDGKEDRYGCYQELVVKSLMHLGTLEKSASAQTIIENLNDSGIQSLKAEGDEVDECFMVPSDDGKDKTDNSRLRFSPSSDSDSNSESAENGWDSGSSFSEEAKPPRVPKYVLVDDRKDLLEVPEIKTEGNKFISCKNVCDSETERKDPQNTPLDPSDGPAQPSFPGSEEDGRGCPAAGTEEATALEKAKGNLSLLEQAIALQAERGCVFHNTYKELDRFLLEHLSGERRQTKVIDMGGRQVFPNKHSPRPEKRETKCPIPGCDGTGHVTGLYPHHRSLSGCPHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMSQDKSQLDSPKTGQCPEQGHRTSLVKQIEFNFRSQAITSPRATVSKEQEKFGKIPFDYASFDAQVFGKCPLVQTGRKTPPFPESKHFSSPGKFPPRLPSAGAHTQSPGRASSYGSGQRSEDTHIAAAAAILNLSTRCREAADILANRQQGLHAKGAEIEVDENGTLDLSMKKARILDKVAPLTSTNPSVPTASSSPFKTSSLLVNAAFYQALCDHEGWDTPINYSKAHGKTEEEKEKDPVSSLENLEEKKFSGEASIPSPKPKLHTRDLKKELITCPTPGCDGSGHVTGNYASHRSVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKGGVKVTPTKEEKEDPELKCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGAPLSWKLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQAIKKGKVSEELMTIKVKASGGIENDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQNNESLLKELAGLSQALISSLADIQLPQMGPISEQNFEAYVNTLTDMYSNLERDYSPECKALLESIKQAVKGIHV", "length": 1048, "header": "tr|F1N2X8-1|F1N2X8_BOVIN Isoform 1 of ST18 C2H2C-type zinc finger transcription factor OS=Bos taurus OX=9913 GN=ST18 PE=3 SV=4 CANONICAL=F1N2X8-1" }, "locus": { "chromosome": "14", "start_pos": 21242013, "end_pos": 21160404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007308.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007308.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007308.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007308.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 417, "start_aa": "Thr", "end_pos": 417, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr417", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 727, "start_aa": "Thr", "end_pos": 727, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr727", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 771, "start_aa": "Thr", "end_pos": 771, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr771", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "interleukin-1-mediated signaling pathway", "id": "GO:0070498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070498", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "interleukin-6-mediated signaling pathway", "id": "GO:0070102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070102", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "protein-DNA complex", "id": "GO:0032993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N2X8", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 672, "end_pos": 674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 938, "end_pos": 940, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2X8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1048, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2X8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2X8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2X8" }, { "id": "PF08474", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08474" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myelin transcription factor 1", "eco_id": "ECO_0000259", "start_pos": 483, "end_pos": 716, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 417, 727, 771 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 612, "end_pos": 614 }, { "start_pos": 672, "end_pos": 674 }, { "start_pos": 938, "end_pos": 940 }, { "start_pos": 976, "end_pos": 978 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2X9-1", "uniprot_ac": "F1N2X9", "uniprot_id": "F1N2X9_BOVIN", "mass": { "chemical_mass": 34880.0, "monoisotopic_mass": 34880.0 }, "refseq": { "ac": "NP_001377135", "name": "olfactory receptor family 6 subfamily C member 4", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377135" }, "gene_names": [ { "name": "OR6C4", "type": "recommended", "evidence": [ { "id": "F1N2X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2X9" } ] }, { "name": "OR6C4", "type": "synonym", "evidence": [ { "id": "NP_001377135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377135" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N2X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2X9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 6C4", "type": "synonym", "evidence": [ { "id": "NP_001377135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377135" } ] }, { "name": "olfactory receptor family 6 subfamily C member 4", "type": "synonym", "evidence": [ { "id": "NP_001377135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377135" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377135" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N2X9", "url": "https://www.uniprot.org/uniprotkb/F1N2X9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2X9", "url": "https://www.uniprot.org/uniprotkb/F1N2X9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C4", "url": "https://www.uniprot.org/uniprotkb/F1N2X9", "locus": { "chromosome": "5", "start_pos": 57724117, "end_pos": 57725043, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065799", "url": "https://www.ensembl.org/id/ENSBTAG00000065799" } ] } } ], "crossref": [ { "id": "F1N2X9", "url": "https://alphafold.ebi.ac.uk/entry/F1N2X9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615284", "url": "https://www.ncbi.nlm.nih.gov/gene/615284", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615284", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615284", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MSNRICI", "url": "https://omabrowser.org/oma/group/MSNRICI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2X9", "url": "https://www.orthodb.org/?gene=F1N2X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377135", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2X9", "url": "https://www.uniprot.org/uniprotkb/F1N2X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2X9-1", "url": "https://www.uniprot.org/uniprotkb/F1N2X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNRTFTEFILLGLTNQPEVQALIFIFLFLTYMLSVLGNLTIIILTLVDSHLQTPMYFFLRNFSFLEVSFTSIFIPRFLTSMTTGNKAISFVGCLIQYFFAIFLGATEFYLLASMSYDRYVAICKPLHYLTVMNSRVCIQLVFCSWLGGFLAIFPPIILMSQVDFCASNVLNHYYCDYGPLLELACSDTSLLELMVISLAVLTLVVTLVLVTLSYTYIIRTILRIPSAQQRAKAFSTCSSHMIVISLSYGSCMFMYINPSAKEEGAFNKGIAVLITSITPLLNPFIYTLRNQQVKQAFKDTIKKIVKL", "length": 308, "header": "tr|F1N2X9-1|F1N2X9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C4 PE=3 SV=3 CANONICAL=F1N2X9-1" }, "isoforms": [ { "isoform_ac": "F1N2X9-1", "url": "https://www.uniprot.org/uniprotkb/F1N2X9/entry", "sequence": { "sequence": "MKNRTFTEFILLGLTNQPEVQALIFIFLFLTYMLSVLGNLTIIILTLVDSHLQTPMYFFLRNFSFLEVSFTSIFIPRFLTSMTTGNKAISFVGCLIQYFFAIFLGATEFYLLASMSYDRYVAICKPLHYLTVMNSRVCIQLVFCSWLGGFLAIFPPIILMSQVDFCASNVLNHYYCDYGPLLELACSDTSLLELMVISLAVLTLVVTLVLVTLSYTYIIRTILRIPSAQQRAKAFSTCSSHMIVISLSYGSCMFMYINPSAKEEGAFNKGIAVLITSITPLLNPFIYTLRNQQVKQAFKDTIKKIVKL", "length": 308, "header": "tr|F1N2X9-1|F1N2X9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C4 PE=3 SV=3 CANONICAL=F1N2X9-1" }, "locus": { "chromosome": "5", "start_pos": 57725043, "end_pos": 57724120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055881.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055881.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052784.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052784.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615284", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615284", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SQF3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100156762", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKNQTTFTEFILLGLTNQPEVQVVIFIFLFLTYLLSVLGNLTIIILTLVDPHLQTPMYFFLRNFSFLEVCFTSIFIPRFLTSLTTGNKVISFAGCLIQYFFAIFLGATEFYLLASMSYDRYVAICKPLHYLTIMNSRVCIQLVFSSWLGGFLAIFPPIFLMSQVDFCASNVLNHYYCDYGPLLELACSDTSLLELTVIFLAVVTLVVTLVLVTLSYTFIIRTILRIPSAQQRTKAFSTCSSHMIVISRSYGSCMFMYINPSAKEEGSFNKAIAVLITSITPLLNPFIYTLRNQQVKQAFKDTIKKIVKL", "length": 309 }, "evidence": [ { "id": "F1N2X9", "url": "https://omabrowser.org/oma/group/F1N2X9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N2X9", "url": "https://www.uniprot.org/uniprotkb/F1N2X9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N2X9", "url": "https://www.uniprot.org/uniprotkb/F1N2X9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2X9", "url": "https://www.uniprot.org/uniprotkb/F1N2X9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2X9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2X9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2X9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2X9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 39, "end_pos": 41 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2Y0-1", "uniprot_ac": "F1N2Y0", "uniprot_id": "F1N2Y0_BOVIN", "mass": { "chemical_mass": 34409.0, "monoisotopic_mass": 34409.0 }, "refseq": { "ac": "NP_001376998", "name": "olfactory receptor family 9 subfamily E member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376998" }, "gene_names": [ { "name": "OR9E2", "type": "recommended", "evidence": [ { "id": "F1N2Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" } ] }, { "name": "OR9E2", "type": "synonym", "evidence": [ { "id": "NP_001376998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376998" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N2Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 1038", "type": "synonym", "evidence": [ { "id": "NP_001376998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376998" } ] }, { "name": "olfactory receptor family 9 subfamily E member 2", "type": "synonym", "evidence": [ { "id": "NP_001376998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376998" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376998" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9E2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0", "locus": { "chromosome": "7", "start_pos": 40961073, "end_pos": 40960150, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039804", "url": "https://www.ensembl.org/id/ENSBTAG00000039804" } ] } } ], "crossref": [ { "id": "F1N2Y0", "url": "https://alphafold.ebi.ac.uk/entry/F1N2Y0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039804", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039804", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15227", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15227", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524985", "url": "https://www.ncbi.nlm.nih.gov/gene/524985", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524985", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524985", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WECVAQL", "url": "https://omabrowser.org/oma/group/WECVAQL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2Y0", "url": "https://www.orthodb.org/?gene=F1N2Y0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376998", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2Y0-1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTNETMVTEFILKGFSDVPELRLISTIFFLFIYLFALLGNISIIAAVSRDSRLHIPMYFFLKNLSFLDMCYTTVIVPKALINSLMGSEVISFWECVAQLFLFVTLCASECFLLTSMAYDRCLAIYKPLLYGVIMSRKLCTELVMVAWLSGAFYAIFHTINTFSLQFCGPNVIDHFFCDSSPIMRLSCSDSHTNEEIGFVVGGCTILGAFALTIISYVLIIATIARTQSAGGRWKAFSTCSSHLTTIILFYVTGSIAYLRPTSHYFPLQGRLVSVFYSILTPSLNPVVYCLRNTDMQAALKKLFVPSK", "length": 307, "header": "tr|F1N2Y0-1|F1N2Y0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9E2 PE=3 SV=2 CANONICAL=F1N2Y0-1" }, "isoforms": [ { "isoform_ac": "F1N2Y0-1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0/entry", "sequence": { "sequence": "MTNETMVTEFILKGFSDVPELRLISTIFFLFIYLFALLGNISIIAAVSRDSRLHIPMYFFLKNLSFLDMCYTTVIVPKALINSLMGSEVISFWECVAQLFLFVTLCASECFLLTSMAYDRCLAIYKPLLYGVIMSRKLCTELVMVAWLSGAFYAIFHTINTFSLQFCGPNVIDHFFCDSSPIMRLSCSDSHTNEEIGFVVGGCTILGAFALTIISYVLIIATIARTQSAGGRWKAFSTCSSHLTTIILFYVTGSIAYLRPTSHYFPLQGRLVSVFYSILTPSLNPVVYCLRNTDMQAALKKLFVPSK", "length": 307, "header": "tr|F1N2Y0-1|F1N2Y0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9E2 PE=3 SV=2 CANONICAL=F1N2Y0-1" }, "locus": { "chromosome": "7", "start_pos": 40961070, "end_pos": 40960150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055087.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055087.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052783.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052783.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524985", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524985", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AAA4-1", "protein_name": "Olfactory receptor", "gene_name": "Or5af1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNHTTVTHFILRGFSDVPQLRLVVIPFFLLVYTFGLLGNFSIIMAVRRDSRLHSPMYFFLKNLSFLDMCYTSATIPKAVAISFTGSGVVSYLECVAQLYIIFTFACTECFLLTAMAYDRCLAILRPLLYGTIMSQKYCHALVVTAWVSGAIYSAFHTSNTFSLPYCGPNVVEHFFCDMPAIMRLSCTDYHLTEDVGFAVSSCVVMSSLALTVVSYIGIVATVLRIPSVDGRWKAFSTCSSHLTTVILFYGTGSFVYLRPASHYSPTLGRLASIFYSVVTPSLNPVVYCLRNKDMKFALQKLYCGRKY", "length": 308 }, "evidence": [ { "id": "F1N2Y0", "url": "https://omabrowser.org/oma/group/F1N2Y0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S6N0-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100516783", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTNETTVTEFILKGFSDMPELKLISTIFFLFIYLFAFLGNISVIAAVTRDSHLHIPMYFFLKNLSFLDVCYTTVIIPKAMINSLKGSEVISFWECVVQLFLFVMMCAAECFLLTSMAYDRCLAIHKPLLYGVIMSRKMCMELVIVAWFSGALYAIFHTINTFSLWYCGPNVIDHFFCDSSPIMRLSCSDSHTNEEVGFAVGGCIILGAFALTIISYVLIISTIAQIHCAGGRWNAFSTCSSHLTAVILFYVTGSIAYLRPTSHYSPLQGRLVSVFYSILTPSLNPVVYCLRNKDMQVALKKLFVSSK", "length": 307 }, "evidence": [ { "id": "F1N2Y0", "url": "https://omabrowser.org/oma/group/F1N2Y0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5NC59-1", "protein_name": "Olfactory receptor", "gene_name": "Or9e1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANHTRVTHFILRGFSDVPQLRLVLIPFFLLFYTFGILGNFSIITAVIRDSRLHSPMYFFLKNLSFLDICYTSATIPKAVVISLTGSGVISYQECVAQLYMFITLCGTECFLLTAMAYDRCLAILRPLIYGTIMSHKYCSALVVTAWVGGAIYSAFHTFNTFSLPYCGPNVVDHFFCDMPPVMRLSCTDYHLNEEVGFAVIGCIIMSSFALTVVSYIGIVATVLHIPSVEGRWKAFSTCSSHLTTVILFYGTGSFVYLRPASQYSPTLDPLASIFYSVVTPSLNPVIYCLRNKDMKFALQKLYCGRKY", "length": 308 }, "evidence": [ { "id": "F1N2Y0", "url": "https://omabrowser.org/oma/group/F1N2Y0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y0", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2Y0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2Y0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2Y0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N2Y1-1", "uniprot_ac": "F1N2Y1", "uniprot_id": "F1N2Y1_BOVIN", "mass": { "chemical_mass": 32110.0, "monoisotopic_mass": 32110.0 }, "refseq": { "ac": "NP_001377597", "name": "olfactory receptor family 2 subfamily Z member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377597" }, "gene_names": [ { "name": "OR2Z2", "type": "recommended", "evidence": [ { "id": "F1N2Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" } ] }, { "name": "OR2Z2", "type": "synonym", "evidence": [ { "id": "NP_001377597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377597" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N2Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2Z1", "type": "synonym", "evidence": [ { "id": "NP_001377597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377597" } ] }, { "name": "olfactory receptor family 2 subfamily Z member 2", "type": "synonym", "evidence": [ { "id": "NP_001377597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377597" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377597" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2Z2", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1", "locus": { "chromosome": "7", "start_pos": 42476878, "end_pos": 42476000, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016065", "url": "https://www.ensembl.org/id/ENSBTAG00000016065" } ] } } ], "crossref": [ { "id": "F1N2Y1", "url": "https://alphafold.ebi.ac.uk/entry/F1N2Y1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100299275", "url": "https://www.ncbi.nlm.nih.gov/gene/100299275", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100299275", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299275", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377597", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2Y1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHLFLFSMVVVIYTLAMAGNTAMVLLIWADARLHTPMYFLLSQLSFLDIFFTSVTVPKMIAGFLFGWISISFGGCGAQMFFFMFLGATECILLALMAYDRYVAICNPLRYPLLMSRQTCLLLVAASWLGGSLNASIQTALTLQFPYCGSQKIAHFFCEVPSLLRLACADTAAYEQVLFVTGVVVLLVPIAFITTSYALILAAVLRMHSVEGRKKALATCSSHLAVVNLFYGPLVYTYMLPASYHSPGQDDVVSVFYTVLTPMLNPVIYSLRNKEVTGAMKKVIGKCGVGRTV", "length": 292, "header": "tr|F1N2Y1-1|F1N2Y1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2Z2 PE=3 SV=4 CANONICAL=F1N2Y1-1" }, "isoforms": [ { "isoform_ac": "F1N2Y1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1/entry", "sequence": { "sequence": "MHLFLFSMVVVIYTLAMAGNTAMVLLIWADARLHTPMYFLLSQLSFLDIFFTSVTVPKMIAGFLFGWISISFGGCGAQMFFFMFLGATECILLALMAYDRYVAICNPLRYPLLMSRQTCLLLVAASWLGGSLNASIQTALTLQFPYCGSQKIAHFFCEVPSLLRLACADTAAYEQVLFVTGVVVLLVPIAFITTSYALILAAVLRMHSVEGRKKALATCSSHLAVVNLFYGPLVYTYMLPASYHSPGQDDVVSVFYTVLTPMLNPVIYSLRNKEVTGAMKKVIGKCGVGRTV", "length": 292, "header": "tr|F1N2Y1-1|F1N2Y1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2Z2 PE=3 SV=4 CANONICAL=F1N2Y1-1" }, "locus": { "chromosome": "7", "start_pos": 42476875, "end_pos": 42476000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057103.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057103.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052780.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052780.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100299275", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299275", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N2Y1", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N2Y1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N2Y1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N2Y1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N2Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2Y1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 268, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N341-1", "uniprot_ac": "F1N341", "uniprot_id": "F1N341_BOVIN", "mass": { "chemical_mass": 34872.0, "monoisotopic_mass": 34872.0 }, "refseq": { "ac": "NP_001377466", "name": "olfactory receptor family 52 subfamily H member 9", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377466" }, "gene_names": [ { "name": "OR52H9", "type": "recommended", "evidence": [ { "id": "F1N341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N341" } ] }, { "name": "OR52H9", "type": "synonym", "evidence": [ { "id": "NP_001377466", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377466" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N341/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 52H1", "type": "synonym", "evidence": [ { "id": "NP_001377466", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377466" } ] }, { "name": "olfactory receptor family 52 subfamily H member 9", "type": "synonym", "evidence": [ { "id": "NP_001377466", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377466" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377466" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52H9", "url": "https://www.uniprot.org/uniprotkb/F1N341", "locus": { "chromosome": "15", "start_pos": 47681806, "end_pos": 47682747, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051804", "url": "https://www.ensembl.org/id/ENSBTAG00000051804" } ] } } ], "crossref": [ { "id": "F1N341", "url": "https://alphafold.ebi.ac.uk/entry/F1N341", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051804", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051804", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "788037", "url": "https://www.ncbi.nlm.nih.gov/gene/788037", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788037", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788037", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LSCYNPG", "url": "https://omabrowser.org/oma/group/LSCYNPG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N341", "url": "https://www.orthodb.org/?gene=F1N341", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF138", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF138", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377466", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N341-1", "url": "https://www.uniprot.org/uniprotkb/F1N341-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYNLSCYNPGSFILAGIPGLEKFHVWIGIPFCVIYGLAIVGNGTLLYLIVVEDSLHEPMFFFLSLLATTDLILSTDTVPKLLSNLWLGSQEITFTGCLAQMFFLHFSFVVDSAILLTMALDRYVAICFPLRYTSILAPQVIIKLVVVIVVRSFSVILPDVFLLKRLPFCGTRIIPHTYCEHIGVARLSSTDISINIWYGFSVPVMTVASDVIFIAVSYIFILRAVFHLSSQGARQKALGTCGSHVCVILIFYTPAAFSILAHRFGHSVPRNMLILFANFYVAIPPALNPVVYGVKTKKIQDKFVLLFTLKKTQ", "length": 313, "header": "tr|F1N341-1|F1N341_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52H9 PE=3 SV=3 CANONICAL=F1N341-1" }, "isoforms": [ { "isoform_ac": "F1N341-1", "url": "https://www.uniprot.org/uniprotkb/F1N341/entry", "sequence": { "sequence": "MYNLSCYNPGSFILAGIPGLEKFHVWIGIPFCVIYGLAIVGNGTLLYLIVVEDSLHEPMFFFLSLLATTDLILSTDTVPKLLSNLWLGSQEITFTGCLAQMFFLHFSFVVDSAILLTMALDRYVAICFPLRYTSILAPQVIIKLVVVIVVRSFSVILPDVFLLKRLPFCGTRIIPHTYCEHIGVARLSSTDISINIWYGFSVPVMTVASDVIFIAVSYIFILRAVFHLSSQGARQKALGTCGSHVCVILIFYTPAAFSILAHRFGHSVPRNMLILFANFYVAIPPALNPVVYGVKTKKIQDKFVLLFTLKKTQ", "length": 313, "header": "tr|F1N341-1|F1N341_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52H9 PE=3 SV=3 CANONICAL=F1N341-1" }, "locus": { "chromosome": "15", "start_pos": 47682747, "end_pos": 47681809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002647.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002647.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002647.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002647.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788037", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788037", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A7N5-1", "protein_name": "Olfactory receptor", "gene_name": "Or52h9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYNLSCYNPYSFILVGIPGLEKFHIWIGIPFCVIYVVAIVGNCILLYLIAVEQSLHEPMFIFLSMLASTDIILSTATVPKLLSNLWFGSQEITFSGCLSQMFFLHFSFVVDSAILLAMAFDRYVAICLPLRYSTILTPQVIVKIMVSIIVRSFSVILPDVFLLRRLPFCKTRVIPHTYCEHIGVARLSSADISINIWYGFSVPLMTVISDVILIAVSYIFILRAVFLLSSQGARQKALSTCGSHVCVILMFYTPAFFSILAHRFGHSVPRNVLILFANFYVAIPPALNPVVYGVKTKQIQDKFLLFFSLRKTQ", "length": 313 }, "evidence": [ { "id": "F1N341", "url": "https://omabrowser.org/oma/group/F1N341/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IDI1-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100772104", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYNLSCYNPTSFILVGIPGLEKFHIWIGIPFCVIYVVAIVGNCILLYLIAVEQSLHEPMFIFLSMLASTDLILSTATVPKLLSNLWFGSQEITFSGCLTQMFFLHFSFVVDSAILLAMAFDRYVAICLPLRYNTILTPQVIVKIMVSIVVRSFSVILPDVFLLKRLPFCKTRVIPHTYCEHIGVARLSSADISINIWYGFSVPLMTVVSDVILIAVSYIFILRAVFLLSSQGARQKALSTCGSHVCVILMFYTPAFFSILAHRFGHSVPRNVLILFANFYVAIPPALNPVVYGVKTKQIQDKFLLFLSLRKTQ", "length": 313 }, "evidence": [ { "id": "F1N341", "url": "https://omabrowser.org/oma/group/F1N341/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8VG78-1", "protein_name": "Olfactory receptor", "gene_name": "Or52h9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYNLSCYNPASFTLVGIPGLEKFHIWIGIPFCVIYVVAIVGNCILLYLIAVEQSLHEPMFIFLSMLASTDLILSTATVPKLLSNLWFGSQEITFSGCLTQMFFLHFSFVVDSAILLAMAFDRYVAICLPLRYSTILTPQVIVKIMVSIIVRSFSVILPDVFLLRRLPFCKTRVIPHTYCEHIGVARLSSADISINIWYGFSVPLMTVISDVILIAVSYIFILRAVFLLSSQGARQKALSTCGSHICVILMFYTPAFFSILAHRFGHSVPRNVLILFANFYVAIPPALNPVVYGVKTKQIQDKFLLFFSLRKTQ", "length": 313 }, "evidence": [ { "id": "F1N341", "url": "https://omabrowser.org/oma/group/F1N341/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N341", "url": "https://www.uniprot.org/uniprotkb/F1N341" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N341-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N341-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N341" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N341" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 292, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N348-1", "uniprot_ac": "F1N348", "uniprot_id": "F1N348_BOVIN", "mass": { "chemical_mass": 58171.0, "monoisotopic_mass": 58171.0 }, "refseq": { "ac": "NP_001192715", "name": "amphoterin-induced protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192715" }, "gene_names": [ { "name": "AMIGO2", "type": "recommended", "evidence": [ { "id": "F1N348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ] }, { "name": "AMIGO2", "type": "synonym", "evidence": [ { "id": "NP_001192715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192715" } ] } ], "protein_names": [ { "name": "Amphoterin-induced protein 2", "type": "recommended", "evidence": [ { "id": "F1N348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N348/entry#names_and_taxonomy" } ] }, { "name": "AMIGO-2", "type": "synonym", "evidence": [ { "id": "F1N348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N348/entry#names_and_taxonomy" } ] }, { "name": "amphoterin induced gene 2", "type": "synonym", "evidence": [ { "id": "NP_001192715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192715" } ] }, { "name": "amphoterin-induced protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192715", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192715" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AMIGO2", "url": "https://www.uniprot.org/uniprotkb/F1N348", "locus": { "chromosome": "5", "start_pos": 33173283, "end_pos": 33169078, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002025", "url": "https://www.ensembl.org/id/ENSBTAG00000002025" } ] } } ], "crossref": [ { "id": "F1N348", "url": "https://alphafold.ebi.ac.uk/entry/F1N348", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002025", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002025", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514273", "url": "https://www.ncbi.nlm.nih.gov/gene/514273", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514273", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514273", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DFVWVGP", "url": "https://omabrowser.org/oma/group/DFVWVGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N348", "url": "https://www.orthodb.org/?gene=F1N348", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24368", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24368", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24368:SF209", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24368:SF209", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192715", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N348-1", "url": "https://www.uniprot.org/uniprotkb/F1N348-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLRLHALPTLPGVVRPGCKQLLCLLVITMTVSRGASGVCPTACICATDIVSCTNKNLSRVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSLVKLNTLIIRHNNITSISTDSFSTTPNLKCLDLSSNKLKTVKSAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRISSLPMHHINLVPGKQLRGIFLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDTRHFHQVLLLQDSFLNCSDSIINSSFRALGFIHEAQVGERLMVHCDGKTGRANTDFMWVGPDNRVLEPDKEMENFHVFPNGSLVIESPRFEDAGVYSCVAMNRQRLLNETVDVTINVSNFTINKSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKHKRRKNMLNQSNVHASILTSGPDSDAPTDERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSETVIAEGILKSTRVKSDSDSVNSVFSDTPFVAST", "length": 521, "header": "tr|F1N348-1|F1N348_BOVIN Isoform 1 of Amphoterin-induced protein 2 OS=Bos taurus OX=9913 GN=AMIGO2 PE=3 SV=2 CANONICAL=F1N348-1" }, "isoforms": [ { "isoform_ac": "F1N348-1", "url": "https://www.uniprot.org/uniprotkb/F1N348/entry", "sequence": { "sequence": "MSLRLHALPTLPGVVRPGCKQLLCLLVITMTVSRGASGVCPTACICATDIVSCTNKNLSRVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSLVKLNTLIIRHNNITSISTDSFSTTPNLKCLDLSSNKLKTVKSAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRISSLPMHHINLVPGKQLRGIFLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDTRHFHQVLLLQDSFLNCSDSIINSSFRALGFIHEAQVGERLMVHCDGKTGRANTDFMWVGPDNRVLEPDKEMENFHVFPNGSLVIESPRFEDAGVYSCVAMNRQRLLNETVDVTINVSNFTINKSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKHKRRKNMLNQSNVHASILTSGPDSDAPTDERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSETVIAEGILKSTRVKSDSDSVNSVFSDTPFVAST", "length": 521, "header": "tr|F1N348-1|F1N348_BOVIN Isoform 1 of Amphoterin-induced protein 2 OS=Bos taurus OX=9913 GN=AMIGO2 PE=3 SV=2 CANONICAL=F1N348-1" }, "locus": { "chromosome": "5", "start_pos": 33171962, "end_pos": 33170400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002625.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002625.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002625.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002625.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 42, "start_aa": "Thr", "end_pos": 42, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr42", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514273", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514273", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YUJ7-1", "protein_name": "Amphoterin-induced protein 2", "gene_name": "AMIGO2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLNCRTLPIQLGACKVNCRALVCLLVFAVSVSGSAPGMCPTTCICASDIISCTNKNLSRVPGNLYRSMKRLDLSYNRIGFLEPEWVPVLFEKLNTLIINHNSISSIITGSFSTTPNLKYLDLSSNSLKTLGSPVFQELGTLEVLLLYNNQITHIESSAFGGLYKLQKLYLSYNFLLHFPLDLFVGKHKLTELILLDISFNHIQSMPIQRLSSVPAKHLSGVYLHGNPFYCDCTLYSMLIFWYQRHFSSVVDFKSEYTCLLRSDPRGYNKQPLLHDNFLNCSESTINSSFQAFGFIHDAQVGDRLIVHCDSRISDAGTHFVWVSPENKLLEPDMETDKFRVFHNGSLEITDAQLEDSGLYSCTAINKRRLLNETIEVRINVSNFTVNRPHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCQCKTKRKKRKLNQSSAHTSILNSTPPQELPADEKKASTGKRVVFLEPVHEPKHSQNGKVKLFPNDNVIAESILKTTRTKSDSDSVNSVFSDTPFMPST", "length": 521 }, "evidence": [ { "id": "F1N348", "url": "https://omabrowser.org/oma/group/F1N348/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SGW7-1", "protein_name": "Amphoterin-induced protein 2", "gene_name": "AMIGO2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLRLRALPTLPRVVRPGCRELLCLLVITVTVSRGTSGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWLPVSFVKLNTLIIRHNNITSISTDSFSTTPNLKCLDLSSNKLKTVKSAVFQELKVLEVLLLYNNHISYLDPSAFGGLPHLQKLYLSGNFLMQFPMDLYLGRFKLAELMFLDVSYNRISSLPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDTRHFHQVLLLQDSFLNCSDSIVNGSFRALGFIHEAQVGERLIVHCDSKTGNSNTDFMWVGPDNRVLEPEKEMKNFHVFPNGSLVIESPRFEDAGVYSCIAMNRQRLLNETVDVTINVSNFTMNRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKPKRQKHMLNQSSVQASILAPGPDSDAPADERKASAGKRVVFLEPLKDTAAGQNGKVRLFPSETVIAEGILKSSRVKSDSDSVNSVFSDTPFVAST", "length": 521 }, "evidence": [ { "id": "F1N348", "url": "https://omabrowser.org/oma/group/F1N348/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7TNJ4-1", "protein_name": "Amphoterin-induced protein 2", "gene_name": "Amigo2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSSSGLCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLIVRHNNITSISTGSFSTTPNLKCLDLSSNRLKSVKSAMFQELKVLEVLLLYNNHISYLDPAAFGGLSHLQKLYLSGNFLTKFPMDLYVGRFKLADLTFLDVSYNQIASIPMHHINLVPGKQLRGIFLHGNPFVCDCSLYSLLTFWYRRHFNSVTDFKHDYTCRLWLDSRHSHQLLLLQDSFLNCSHSVINGSFHALGFIHEAQVGERAIVHCDGKTGNGNTDFIWVGPDNRLLEPDKDTGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHHAHEAFNTAFTTLAACVVSIVLVLLYLYLTPCPCKCRDKRQKNALNQSNAHSSILSPGPTRDASAEDRKAGKRVVFLEPLKDPAVGQNGKVKLVPSKTVIAEGILKSSRAKSDSDSVNSVFSDTPFVAST", "length": 520 }, "evidence": [ { "id": "F1N348", "url": "https://omabrowser.org/oma/group/F1N348/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80ZD9-1", "protein_name": "Amphoterin-induced protein 2", "gene_name": "Amigo2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSASGMCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLILRHNNITSISTGSFSTTPNLKCLDLSSNRLKSVKSATFQELKALEVLLLYNNHISYLDPAAFGGLSHLQKLYLSGNFLTQFPMDLYTGRFKLADLTFLDVSYNRIPSIPMHHINLVPGRQLRGIYLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDSRHSHQLQLLQESFLNCSYSVINGSFHALGFIHEAQVGERAIVHCDSKTGNGNTDFIWVGPDNRLLEPDKDMGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKAKRQKNTLSQSSAHSSILSPGPTGDASADDRKAGKRVVFLEPLKDTAAGQNGKVKLFPSETVIAEGILKSTRAKSDSDSVNSVFSDTPFVAST", "length": 519 }, "evidence": [ { "id": "F1N348", "url": "https://omabrowser.org/oma/group/F1N348/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86SJ2-1", "protein_name": "Amphoterin-induced protein 2", "gene_name": "AMIGO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSSILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAVIAEGILKSTRGKSDSDSVNSVFSDTPFVAST", "length": 522 }, "evidence": [ { "id": "F1N348", "url": "https://omabrowser.org/oma/group/F1N348/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "F1N348", "url": "https://www.uniprot.org/uniprotkb/F1N348" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N348-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 521, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N348-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N348" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N348" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 302, "end_pos": 378, "start_aa": "Gly", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 42 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 372, "end_pos": 374 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 435, "end_pos": 437 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N362-1", "uniprot_ac": "F1N362", "uniprot_id": "F1N362_BOVIN", "mass": { "chemical_mass": 64131.0, "monoisotopic_mass": 64131.0 }, "refseq": { "ac": "NP_001179264", "name": "keratin, type II cuticular Hb4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179264" }, "gene_names": [ { "name": "KRT84", "type": "recommended", "evidence": [ { "id": "F1N362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ] }, { "name": "KRT84", "type": "synonym", "evidence": [ { "id": "NP_001179264", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179264" } ] } ], "protein_names": [ { "name": "Keratin 84", "type": "synonym", "evidence": [ { "id": "F1N362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N362/entry#names_and_taxonomy" } ] }, { "name": "keratin, type II cuticular Hb4", "type": "synonym", "evidence": [ { "id": "NP_001179264", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179264" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT84", "url": "https://www.uniprot.org/uniprotkb/F1N362", "locus": { "chromosome": "5", "start_pos": 27513634, "end_pos": 27505840, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047872", "url": "https://www.ensembl.org/id/ENSBTAG00000047872" } ] } } ], "crossref": [ { "id": "F1N362", "url": "https://alphafold.ebi.ac.uk/entry/F1N362", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047872", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047872", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539944", "url": "https://www.ncbi.nlm.nih.gov/gene/539944", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539944", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539944", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EQKCARS", "url": "https://omabrowser.org/oma/group/EQKCARS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N362", "url": "https://www.orthodb.org/?gene=F1N362", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179264", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N362-1", "url": "https://www.uniprot.org/uniprotkb/F1N362-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCRSYRVSSGRCVGNFSSCSAVTPQNLNRFRASSVSCRSGPSFRGLSSFGSRSVISFGSCSPRIAAVCPRPSCYGVGFGDGSGAGLGFGVGSCVGLGFGARSGLGYGFCNPGFGYRVGGIGGPAAPSITAVTVNQSLLTPLNLEIDPNAQRVKRDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWNFLQEQKCAKSNLEPLFENYITNLRRQLDVVNSDQARLEAERNHMQDVLEGFKKKYEEEVGLRASAENEFVALKKDVDTAFLSKADLEANVDTLIQEIDFLKTLYEAEIQLLQSHISETSVIVKMDNSRDLNVDGIIADIKAQYEEIARRSRADAEAWYQTKYEEMRVTAGQHCDNLRNTRDEMNELNRLIQRLKAEIEHAKAQRCKLEAAVAEAEQQGEAALNDAKCKLAELEGALQQAKQDMARQLKEYQELMNVKLALDIEIATYRRLLEGEEIRICEGVGPVDIAVSSSRGGLVCGPESLYSSSSLCRGGVIISGSGSSSNIRSSGFCSSSVGGARVVGGGDLLGAGSRGGSVLVGEVCAPSVPCPLPTEGGFSSCSGGRSSRSSTVRFVSTTTSHRTKH", "length": 593, "header": "tr|F1N362-1|F1N362_BOVIN Isoform 1 of Keratin 84 OS=Bos taurus OX=9913 GN=KRT84 PE=3 SV=2 CANONICAL=F1N362-1" }, "isoforms": [ { "isoform_ac": "F1N362-1", "url": "https://www.uniprot.org/uniprotkb/F1N362/entry", "sequence": { "sequence": "MSCRSYRVSSGRCVGNFSSCSAVTPQNLNRFRASSVSCRSGPSFRGLSSFGSRSVISFGSCSPRIAAVCPRPSCYGVGFGDGSGAGLGFGVGSCVGLGFGARSGLGYGFCNPGFGYRVGGIGGPAAPSITAVTVNQSLLTPLNLEIDPNAQRVKRDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWNFLQEQKCAKSNLEPLFENYITNLRRQLDVVNSDQARLEAERNHMQDVLEGFKKKYEEEVGLRASAENEFVALKKDVDTAFLSKADLEANVDTLIQEIDFLKTLYEAEIQLLQSHISETSVIVKMDNSRDLNVDGIIADIKAQYEEIARRSRADAEAWYQTKYEEMRVTAGQHCDNLRNTRDEMNELNRLIQRLKAEIEHAKAQRCKLEAAVAEAEQQGEAALNDAKCKLAELEGALQQAKQDMARQLKEYQELMNVKLALDIEIATYRRLLEGEEIRICEGVGPVDIAVSSSRGGLVCGPESLYSSSSLCRGGVIISGSGSSSNIRSSGFCSSSVGGARVVGGGDLLGAGSRGGSVLVGEVCAPSVPCPLPTEGGFSSCSGGRSSRSSTVRFVSTTTSHRTKH", "length": 593, "header": "tr|F1N362-1|F1N362_BOVIN Isoform 1 of Keratin 84 OS=Bos taurus OX=9913 GN=KRT84 PE=3 SV=2 CANONICAL=F1N362-1" }, "locus": { "chromosome": "5", "start_pos": 27512832, "end_pos": 27506039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021519.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021519.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021519.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021519.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 24, "start_aa": "Thr", "end_pos": 24, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr24", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539944", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539944", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0I4-1", "protein_name": "Keratin 84", "gene_name": "Krt84", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSCRSYRVSSGRRVGNFSSCSAMTPQHLNRFRASSVSCRSGPGFRGLGGFGSRSVINFGSSSPRIAVGCSRPIRYGVGFGAGNGIAFGSGDGSGICLGYRAGSGVGLGFGAGSCLGYGFGGPGFGGPGFGGPGFGYRIGGIGGPSAPAITAVTVNQSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQDQKCARSNLEPLFDNYITSLRRQLDVLVSDQARLQAERNHMQDILEGFKKKYEEEVVFRANAENEFVALKKDVDAAFLNKSDLEANVDALAQEIEFLKALYLEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADVESWYQTKYEEMRVTAGQHCDNLRNTRDEINELTRLIQRLKTEIEHTKAQCAKLEAAVAEAEQQGEAALNDAKCKLTDLEGALQQAKQDMARQLREYQELMNAKLALDIEIVTYRKLLEGEEIRICEGVGPVNISVSSSRGGVLCGPESLVCGSGLSHSGGVTFSSSSGIRATGGILASSSLRAGGDLLSSGTRGGSVLVGDACAPSIPCALPTEGGFSSCSGGRGNRSSSIRFSSTTTSRRSRY", "length": 608 }, "evidence": [ { "id": "F1N362", "url": "https://omabrowser.org/oma/group/F1N362/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SGI2-1", "protein_name": "Keratin 84", "gene_name": "KRT84", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSCRSYRVSSGRRVGNFSSCSAMTHQNLNRFRTSSVSCRSGPSFRGLGGFGSRSVISFGSCSPRIAAVGPRPIRCGVGFGVGSGMAFGYGDGSGAGLGFGSGSCVGLGFGAGSGLGYGFGGPGFGYRVGGIGVPAAPSITAVTVNQSLLTPLNLEIDPNAQRVKRDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKGTRSNLEPLFENYITNLRHQLDVVSSDRARLEAERNNMQDVLEGFKKKYEEEVVLRANAENEFVALKKDVDSAFLNKSDMEANVDSLTQEIDFLKTLYMAEIQLLQSHISETSVIVKMDNSRDLNVDGIIADIKAQYEEIARRSRADAESWYQTKYEEMRVTAGQHCDNLRSTRDEINELNRLIQRLKAEIEHAKAQRAKLEAAVAQAEQQGEAALNDAKSKLADLEGALQQAKQDMARQLREYQELMNVKLALDIEIATYRRLLEGEEIRICEGVGPVDISVSSSRGGVVCGPDALVTSSGLSRGGVAFSGGSSIRTSGFCSSSVGGSRVSAGCGGGSVLVGEACAPSVPCPLPTEGGFSSCSGGRSSRGASVRFVSTTTSHRTKY", "length": 593 }, "evidence": [ { "id": "F1N362", "url": "https://omabrowser.org/oma/group/F1N362/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IIF3-1", "protein_name": "Keratin, type II cuticular Hb4", "gene_name": "Krt84", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSCRSYRVSSGHRVGSFSSCSAMTPQNLNRFQASSVSCRSGSGFRGLGCFGSRSVNFGSSSPRIAVGCSRPIRYGVGFGAGNGMAFGSGDGCGVGLGFRASSGVGLGFGAGSSLGYGFGGPAFGGPGFGYRIGGIGGPSAPSITTVTVNQSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQDQKCARSNLDPLFDNYITSLRRQLEVLVSDQARLQAERNHMQDILEGFKKKYEEEVGCRANAENEFVALKKDVDTAFLNKSDLEANVDALAQEVEFLKALYLEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADVEAWYQTKYEEMRVTAGQHCDNLRNTRDEINELTRLIQRLKTEIEHSKAQCAKLEAAVAEAEQQGEAALNDAKCKLADLEGALQQAKQDMARQLREYQELMNAKLGLDIEIATYRQLLEGEEIRICEGVGPVNISVSSSRGGVLCGPESLVSGSSLSRNCGVTFSSSSGIRTTGGVLTSSCLRAGGDLLSSGARGGSVLVSDTCAPSIPCPLPTEGGFSSCSGGRGNRSSSVRFSSTTTSRRTRY", "length": 602 }, "evidence": [ { "id": "F1N362", "url": "https://omabrowser.org/oma/group/F1N362/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q99M73-1", "protein_name": "Keratin, type II cuticular Hb4", "gene_name": "Krt84", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCRSYRVSSGRRVGSFSSCSAMAPQHLNRFRSSSVSCRSGPGFRGLGGFGSRSVINFGSSSPRIAVGCSRPVRCGVGFGAGSGMAFGSGDGLGFRASSGVGLGFGAGGCPSYGFGGPGFGGPGFGGPGFGYRIGGIGGPSAPAITAVTVNQSLLTPLNLEIDPNAQRVKRDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCARSNLEPLFDNYITNLRRQLDVLSSDQARLQAERNHLQDILEGFKKKYEEEVVFRANAENEFVALKKDVDAAFLNKSDLEANVDTLIQETEFLKALYHEEIEMLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADVESWYQTKYEEMRVTAGQHCDNLRSTRDEINELTRLIQRLKAEIEHTKAQCAKLEAAVAEAEQQGEAALNDAKCKLADLEGALQQAKQDMARQLREYQELMNVKLALDIEIVTYRRLLEGEEIRICEGVGPVNISVSSSRGGVLCGPELVSGSSLSHNGGVTFSTSSSIRATGGVLASSSLRAGGDLLSSGSRGGSVLVGDACAPSIPCALPTEGGFSSCSGGRGNRSSSVRFSSTTTSRRTRY", "length": 603 }, "evidence": [ { "id": "F1N362", "url": "https://omabrowser.org/oma/group/F1N362/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NSB2-1", "protein_name": "Keratin, type II cuticular Hb4", "gene_name": "KRT84", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSCRSYRVSSGHRVGNFSSCSAMTPQNLNRFRANSVSCWSGPGFRGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVGLGPRADSCVGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLSRGGVTFSGSSSVCATSGVLASCGPSLGGARVAPATGDLLSTGTRSGSMLISEACVPSVPCPLPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY", "length": 600 }, "evidence": [ { "id": "F1N362", "url": "https://omabrowser.org/oma/group/F1N362/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ], "pmid": "" }, { "name": "regulation of keratinocyte differentiation", "id": "GO:0045616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045616", "evidence": [ { "database": "UniProtKB", "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "F1N362", "url": "https://www.uniprot.org/uniprotkb/F1N362" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N362-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 593, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N362-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N362" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N362" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 157, "end_pos": 468, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 24 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 16, "end_pos": 18 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N373-1", "uniprot_ac": "F1N373", "uniprot_id": "F1N373_BOVIN", "mass": { "chemical_mass": 41557.0, "monoisotopic_mass": 41557.0 }, "refseq": { "ac": "NP_001001600", "name": "pepsin A preproprotein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" }, "gene_names": [ { "name": "PGA5", "type": "recommended", "evidence": [ { "id": "F1N373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ] }, { "name": "PGA5", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] }, { "name": "pga", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] } ], "protein_names": [ { "name": "Pepsin A", "type": "recommended", "evidence": [ { "id": "F1N373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N373/entry#names_and_taxonomy" } ] }, { "name": "3.4.23.1", "type": "synonym", "evidence": [ { "id": "F1N373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N373/entry#names_and_taxonomy" } ] }, { "name": "aspartic peptidase", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] }, { "name": "pepsin A preproprotein", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] }, { "name": "pepsin A", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] }, { "name": "pepsinogen A", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] }, { "name": "pepsinognen A", "type": "synonym", "evidence": [ { "id": "NP_001001600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600" } ] } ], "function": [ { "annotation": "Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.", "evidence": [ { "database": "UniProtKB", "id": "F1N373", "url": "https://www.uniprot.org/uniprotkb/F1N373#function" }, { "database": "UniProtKB", "id": "ARBA00002318", "url": "https://www.uniprot.org/uniprotkb/ARBA00002318#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N373", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGA5", "url": "https://www.uniprot.org/uniprotkb/F1N373", "locus": { "chromosome": "29", "start_pos": 39771367, "end_pos": 39760936, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014761", "url": "https://www.ensembl.org/id/ENSBTAG00000014761" } ] } } ], "crossref": [ { "id": "F1N373", "url": "https://alphafold.ebi.ac.uk/entry/F1N373", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014761", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014761", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05478", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05478", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "414350", "url": "https://www.ncbi.nlm.nih.gov/gene/414350", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:414350", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414350", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MGFWTID", "url": "https://omabrowser.org/oma/group/MGFWTID/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N373", "url": "https://www.orthodb.org/?gene=F1N373", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47966:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47966:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683826", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001001600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001600", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N373", "url": "https://www.uniprot.org/uniprotkb/F1N373", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N373-1", "url": "https://www.uniprot.org/uniprotkb/F1N373-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKWLLLLALVALSECSVVKIPLVKKKSLRQNLIENGKLKEFMRTHKYNLGSKYIREAATLVSEQPLQNYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSIYCSSEACTNHNRFNPQDSSTYEATSETLSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWDQGLVSQDLFSVYLSSNEESGSVVIFGDIDSSYYSGSLNWVPVSVEGYWQITVDSITMNGESIACSDGCQAIVDTGTSLLAGPTTAISNIQSYIGASEDSSGEVVISCSSIDSLPDIVFTINGVQYPVPPSAYILQSNGICSSGFEGMDISTSSGDLWILGDVFIRQYFTVFDRGNNQIGLAPVA", "length": 386, "header": "tr|F1N373-1|F1N373_BOVIN Isoform 1 of Pepsin A OS=Bos taurus OX=9913 GN=PGA5 PE=3 SV=2 CANONICAL=F1N373-1" }, "isoforms": [ { "isoform_ac": "F1N373-1", "url": "https://www.uniprot.org/uniprotkb/F1N373/entry", "sequence": { "sequence": "MKWLLLLALVALSECSVVKIPLVKKKSLRQNLIENGKLKEFMRTHKYNLGSKYIREAATLVSEQPLQNYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSIYCSSEACTNHNRFNPQDSSTYEATSETLSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWDQGLVSQDLFSVYLSSNEESGSVVIFGDIDSSYYSGSLNWVPVSVEGYWQITVDSITMNGESIACSDGCQAIVDTGTSLLAGPTTAISNIQSYIGASEDSSGEVVISCSSIDSLPDIVFTINGVQYPVPPSAYILQSNGICSSGFEGMDISTSSGDLWILGDVFIRQYFTVFDRGNNQIGLAPVA", "length": 386, "header": "tr|F1N373-1|F1N373_BOVIN Isoform 1 of Pepsin A OS=Bos taurus OX=9913 GN=PGA5 PE=3 SV=2 CANONICAL=F1N373-1" }, "locus": { "chromosome": "29", "start_pos": 39771199, "end_pos": 39760973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019640.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019640.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019640.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019640.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 285, "start_aa": "Thr", "end_pos": 285, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr285", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:414350", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414350", "resource": "KEGG Pathway" }, { "id": "R-BTA-5683826", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683826", "resource": "Reactome", "description": "Surfactant metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "P00791-1", "protein_name": "Pepsin A", "gene_name": "PGA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKWLLLLSLVVLSECLVKVPLVRKKSLRQNLIKNGKLKDFLKTHKHNPASKYFPEAAALIGDEPLENYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCSSLACSDHNQFNPDDSSTFEATSQELSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISASGATPVFDNLWDQGLVSQDLFSVYLSSNDDSGSVVLLGGIDSSYYTGSLNWVPVSVEGYWQITLDSITMDGETIACSGGCQAIVDTGTSLLTGPTSAIANIQSDIGASENSDGEMVISCSSIDSLPDIVFTINGVQYPLSPSAYILQDDDSCTSGFEGMDVPTSSGELWILGDVFIRQYYTVFDRANNKVGLAPVA", "length": 385 }, "evidence": [ { "id": "F1N373", "url": "https://omabrowser.org/oma/group/F1N373/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P0DJD7-1", "protein_name": "Pepsin A-4", "gene_name": "PGA4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA", "length": 388 }, "evidence": [ { "id": "F1N373", "url": "https://omabrowser.org/oma/group/F1N373/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N373", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ], "pmid": "" }, { "name": "digestion", "id": "GO:0007586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007586", "evidence": [ { "database": "UniProtKB", "id": "F1N373", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "F1N373", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "multivesicular body lumen", "input_participant_list": [ "R-BTA-5685255" ], "output_participant_list": [ "R-BTA-5685901", "R-BTA-5685910", "R-BTA-5685911" ], "enzyme_list": [ "F1N373-1" ], "evidence": [ { "id": "R-BTA-5684864", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684864" } ] }, { "id": "R-BTA-5685902", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "multivesicular body lumen", "input_participant_list": [ "R-ALL-5685882" ], "output_participant_list": [ "R-BTA-5685871", "R-BTA-5685899" ], "enzyme_list": [ "F1N373-1" ], "evidence": [ { "id": "R-BTA-5685902", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685902" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5685882", "participant_name": "H2O [multivesicular body lumen]", "crossref": [ { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-BTA-5685255", "participant_name": "SFTPB [multivesicular body lumen]", "crossref": [ { "id": "P15781", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000021230", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000042549", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000045134", "database": "ENSEMBL", "url": "" }, { "id": "NP_001068779.1", "database": "RefSeq", "url": "" }, { "id": "XP_005212817.1", "database": "RefSeq", "url": "" }, { "id": "34528", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5685871", "participant_name": "SFTPC [multivesicular body lumen]", "crossref": [ { "id": "ENSBTAP00000016672", "database": "ENSEMBL", "url": "" }, { "id": "34529", "database": "VGNC", "url": "" }, { "id": "A0A452DJB4", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000012560", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000016672", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5685899", "participant_name": "SFTPC [multivesicular body lumen]", "crossref": [ { "id": "A0A452DJB4", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000016672", "database": "ENSEMBL", "url": "" }, { "id": "34529", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000016672", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000012560", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5685901", "participant_name": "SFTPB [multivesicular body lumen]", "crossref": [ { "id": "ENSBTAT00000045134", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000021230", "database": "ENSEMBL", "url": "" }, { "id": "XP_005212817.1", "database": "RefSeq", "url": "" }, { "id": "P15781", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000042549", "database": "ENSEMBL", "url": "" }, { "id": "34528", "database": "VGNC", "url": "" }, { "id": "NP_001068779.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5685910", "participant_name": "SFTPB [multivesicular body lumen]", "crossref": [ { "id": "NP_001068779.1", "database": "RefSeq", "url": "" }, { "id": "P15781", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000042549", "database": "ENSEMBL", "url": "" }, { "id": "34528", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000045134", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000021230", "database": "ENSEMBL", "url": "" }, { "id": "XP_005212817.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5685911", "participant_name": "SFTPB [multivesicular body lumen]", "crossref": [ { "id": "XP_005212817.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000021230", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000045134", "database": "ENSEMBL", "url": "" }, { "id": "34528", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000042549", "database": "ENSEMBL", "url": "" }, { "id": "P15781", "database": "UniProt", "url": "" }, { "id": "NP_001068779.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1N373", "gene_name": "PGA5", "activity": [ { "ec_number": "3.4.23.1", "activity": "Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.", "evidence": [ { "id": "F1N373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ] }, { "ec_number": "3.4.23.1", "activity": "", "evidence": [ { "id": "F1N373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N373" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N373-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 386, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N373-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N373" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N373", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N373" }, { "id": "PS51767", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51767" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase A1", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 383, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.23.1", "ec_name": "Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.", "evidence": [ { "id": "3.4.23.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.23.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 285 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N376-1", "uniprot_ac": "F1N376", "uniprot_id": "F1N376_BOVIN", "mass": { "chemical_mass": 66497.0, "monoisotopic_mass": 66497.0 }, "refseq": {}, "gene_names": [ { "name": "LOC526769", "type": "recommended", "evidence": [ { "id": "F1N376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ] } ], "protein_names": [ { "name": "protein-tyrosine-phosphatase", "type": "recommended", "evidence": [ { "id": "F1N376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N376/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "F1N376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N376/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC526769", "url": "https://www.uniprot.org/uniprotkb/F1N376", "locus": {} } ], "crossref": [ { "id": "F1N376", "url": "https://alphafold.ebi.ac.uk/entry/F1N376", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024492", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024492", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09931", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09931", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14544", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14544", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N376", "url": "https://www.orthodb.org/?gene=F1N376", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46559", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46559", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46559:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46559:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N376-1", "url": "https://www.uniprot.org/uniprotkb/F1N376-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSGQHGSFLARPSKSCPGGFTLSVRRHNEVTHIKIQNTGDYYDLYGGEKFATLAELVQHYTGQHGGLLRERGGAPVELRHPLGCQDPTSERWYHGHLSGKEAEKLLMEKGRPGSFLVRESQSKPGDFVLSVLTQQLDRVDRQPRVTHIMIHFQPDGKYDVGGGEQFDTLGDLVERYRKNPMVERSGVVVHLRQPLKATRISAASIESRVQELSEATDASEKAKQGFWEEFEMLQQQECRLLYPRKEGQRPENKPKNRYKNILPFDTTRVILHDVDDRVPGADYINANYIRAADPTFQSDPEEKPGHGLGKVYIATQGCLPTTVAAFWAMVHQENTHVIVMTTREVERGRNKCFRYWPELHGSQEYGHLHVCNMAEHWAQGYCVRELQVWRPDQEESPHTVKHYQYFSWPDHGVPAEPTGVLSFLEEVNRTHSSMPGAGPMVVHCSAGIGRTGTIIVIDILVDVIRRQGLDCDIDVPKTIQLVRRQRSGMVQTEAQYKFVYLALQRYIQGEQLRLRKPVGAGPGRGGACAGVTMVTRGPSPQRERQEERGSLNLGVSPVDPGCSPGPAPSRAPAATREAPRHEYENLQGLEP", "length": 592, "header": "tr|F1N376-1|F1N376_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=LOC526769 PE=4 SV=4 CANONICAL=F1N376-1" }, "isoforms": [ { "isoform_ac": "F1N376-1", "url": "https://www.uniprot.org/uniprotkb/F1N376/entry", "sequence": { "sequence": "MSSGQHGSFLARPSKSCPGGFTLSVRRHNEVTHIKIQNTGDYYDLYGGEKFATLAELVQHYTGQHGGLLRERGGAPVELRHPLGCQDPTSERWYHGHLSGKEAEKLLMEKGRPGSFLVRESQSKPGDFVLSVLTQQLDRVDRQPRVTHIMIHFQPDGKYDVGGGEQFDTLGDLVERYRKNPMVERSGVVVHLRQPLKATRISAASIESRVQELSEATDASEKAKQGFWEEFEMLQQQECRLLYPRKEGQRPENKPKNRYKNILPFDTTRVILHDVDDRVPGADYINANYIRAADPTFQSDPEEKPGHGLGKVYIATQGCLPTTVAAFWAMVHQENTHVIVMTTREVERGRNKCFRYWPELHGSQEYGHLHVCNMAEHWAQGYCVRELQVWRPDQEESPHTVKHYQYFSWPDHGVPAEPTGVLSFLEEVNRTHSSMPGAGPMVVHCSAGIGRTGTIIVIDILVDVIRRQGLDCDIDVPKTIQLVRRQRSGMVQTEAQYKFVYLALQRYIQGEQLRLRKPVGAGPGRGGACAGVTMVTRGPSPQRERQEERGSLNLGVSPVDPGCSPGPAPSRAPAATREAPRHEYENLQGLEP", "length": 592, "header": "tr|F1N376-1|F1N376_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=LOC526769 PE=4 SV=4 CANONICAL=F1N376-1" }, "locus": { "chromosome": "16", "start_pos": 51415085, "end_pos": 51409391, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034027.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034027.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033929.6", "url": "https://www.ensembl.org/id/ENSBTAP00000033929.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": "UniProtKB", "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ], "pmid": "" }, { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N376", "url": "https://www.uniprot.org/uniprotkb/F1N376" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N376-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 592, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N376-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N376" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N376" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 83, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N376" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 422, "end_pos": 498, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N376" }, { "id": "PS50055", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50055" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 227, "end_pos": 507, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 429, "end_pos": 431 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N378-1", "uniprot_ac": "F1N378", "uniprot_id": "F1N378_BOVIN", "mass": { "chemical_mass": 50867.0, "monoisotopic_mass": 50867.0 }, "refseq": {}, "gene_names": [ { "name": "ETNK1", "type": "recommended", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] } ], "protein_names": [ { "name": "ethanolamine kinase", "type": "recommended", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.82", "type": "synonym", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N378", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETNK1", "url": "https://www.uniprot.org/uniprotkb/F1N378", "locus": { "chromosome": "5", "start_pos": 87559455, "end_pos": 87609606, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005833", "url": "https://www.ensembl.org/id/ENSBTAG00000005833" } ] } } ], "crossref": [ { "id": "F1N378", "url": "https://alphafold.ebi.ac.uk/entry/F1N378", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005833", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005833", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05157", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05157", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22603:SF91", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22603:SF91", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01633", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01633", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N378", "url": "https://www.uniprot.org/uniprotkb/F1N378", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N378-1", "url": "https://www.uniprot.org/uniprotkb/F1N378-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRARRRPSADERNFFREHSPLSSAAVQTRVGESAASTGSPTARPSVTPPALPRGRPGTEGSSSLSAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLDVTVQDQEEQRCREGALSLLQHLRPHWDPQEVTLQLFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIPSSQILQEEMTWMKKILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPGRELQGQWLRSYLEAYKEYKGFGTEVTEKEVEILFIQVNQFALASHFFWGLWALIQAKYSTIDFDFLGYAVVRFNQYFKMKPEVTALKVPE", "length": 451, "header": "tr|F1N378-1|F1N378_BOVIN Isoform 1 of ethanolamine kinase OS=Bos taurus OX=9913 GN=ETNK1 PE=3 SV=3 CANONICAL=F1N378-1" }, "isoforms": [ { "isoform_ac": "F1N378-1", "url": "https://www.uniprot.org/uniprotkb/F1N378/entry", "sequence": { "sequence": "MLRARRRPSADERNFFREHSPLSSAAVQTRVGESAASTGSPTARPSVTPPALPRGRPGTEGSSSLSAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLDVTVQDQEEQRCREGALSLLQHLRPHWDPQEVTLQLFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIPSSQILQEEMTWMKKILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPGRELQGQWLRSYLEAYKEYKGFGTEVTEKEVEILFIQVNQFALASHFFWGLWALIQAKYSTIDFDFLGYAVVRFNQYFKMKPEVTALKVPE", "length": 451, "header": "tr|F1N378-1|F1N378_BOVIN Isoform 1 of ethanolamine kinase OS=Bos taurus OX=9913 GN=ETNK1 PE=3 SV=3 CANONICAL=F1N378-1" }, "locus": { "chromosome": "5", "start_pos": 87609606, "end_pos": 87560459, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007669.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007669.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007669.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007669.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 48, "start_aa": "Thr", "end_pos": 48, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr48", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N378", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ], "pmid": "" }, { "name": "ethanolamine kinase activity", "id": "GO:0004305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004305", "evidence": [ { "database": "UniProtKB", "id": "F1N378", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N378", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphatidylethanolamine biosynthetic process", "id": "GO:0006646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006646", "evidence": [ { "database": "UniProtKB", "id": "F1N378", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1498751" ], "output_participant_list": [], "enzyme_list": [ "G3X782-1", "F1N378-1", "A0A3Q1LRY5-1", "F1MRD9-1" ], "evidence": [ { "id": "R-BTA-1483222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483222" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1498751", "participant_name": "ETA [cytosol]", "crossref": [ { "id": "57603", "database": "ChEBI", "url": "" }, { "id": "ZINC000008214617", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRY5", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] } ] }, { "uniprot_ac": "F1MRD9", "gene_name": "ETNK2", "activity": [ { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "F1MRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "F1MRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ] } ] }, { "uniprot_ac": "F1N378", "gene_name": "ETNK1", "activity": [ { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] } ] }, { "uniprot_ac": "G3X782", "gene_name": "CHKB", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] }, { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N378-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 451, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N378-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N378" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.82", "ec_name": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "2.7.1.82", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82" }, { "id": "2.7.1.82", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.82" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 48 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N380-1", "uniprot_ac": "F1N380", "uniprot_id": "F1N380_BOVIN", "mass": { "chemical_mass": 21384.0, "monoisotopic_mass": 21384.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "AP complex mu/sigma subunit domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1N380", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N380/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380#function" }, { "database": "UniProtKB", "id": "ARBA00025605", "url": "https://www.uniprot.org/uniprotkb/ARBA00025605#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1N380", "locus": {} } ], "crossref": [ { "id": "F1N380", "url": "https://alphafold.ebi.ac.uk/entry/F1N380", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034555", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034555", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14834", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14834", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "THFNEDM", "url": "https://omabrowser.org/oma/group/THFNEDM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N380-1", "url": "https://www.uniprot.org/uniprotkb/F1N380-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFWFFATIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILTNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 188, "header": "tr|F1N380-1|F1N380_BOVIN Isoform 1 of AP complex mu/sigma subunit domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1N380-1" }, "isoforms": [ { "isoform_ac": "F1N380-1", "url": "https://www.uniprot.org/uniprotkb/F1N380/entry", "sequence": { "sequence": "MFWFFATIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILTNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 188, "header": "tr|F1N380-1|F1N380_BOVIN Isoform 1 of AP complex mu/sigma subunit domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1N380-1" }, "locus": { "chromosome": "11", "start_pos": 45896826, "end_pos": 45895958, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048949.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048949.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045902.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045902.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "pmid": "" }, { "name": "AP-3 adaptor complex", "id": "GO:0030123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "pmid": "" }, { "name": "Golgi to vacuole transport", "id": "GO:0006896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006896", "evidence": [ { "database": "UniProtKB", "id": "F1N380", "url": "https://www.uniprot.org/uniprotkb/F1N380" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N380-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 188, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N380-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N380" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N380", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N380" }, { "id": "PF01217", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AP complex mu/sigma subunit", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 129, "start_aa": "Thr", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N389-1", "uniprot_ac": "F1N389", "uniprot_id": "F1N389_BOVIN", "mass": { "chemical_mass": 50432.0, "monoisotopic_mass": 50432.0 }, "refseq": {}, "gene_names": [ { "name": "ZIC1", "type": "recommended", "evidence": [ { "id": "F1N389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ] } ], "protein_names": [ { "name": "Zic family member 1", "type": "synonym", "evidence": [ { "id": "F1N389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N389/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZIC1", "url": "https://www.uniprot.org/uniprotkb/F1N389", "locus": { "chromosome": "1", "start_pos": 120890485, "end_pos": 120900583, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014751", "url": "https://www.ensembl.org/id/ENSBTAG00000014751" } ] } } ], "crossref": [ { "id": "F1N389", "url": "https://alphafold.ebi.ac.uk/entry/F1N389", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014751", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014751", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N389", "url": "https://www.orthodb.org/?gene=F1N389", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N389-1", "url": "https://www.uniprot.org/uniprotkb/F1N389-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSLFAASAGSFGGPHGHTDAAGHLLFPGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPSTDNPTTSSLSPSSSAVHHTAGHSALSSNFNECLWQRKLKVVEEGKTTKKDRGG", "length": 466, "header": "tr|F1N389-1|F1N389_BOVIN Isoform 1 of Zic family member 1 OS=Bos taurus OX=9913 GN=ZIC1 PE=3 SV=4 CANONICAL=F1N389-1" }, "isoforms": [ { "isoform_ac": "F1N389-1", "url": "https://www.uniprot.org/uniprotkb/F1N389/entry", "sequence": { "sequence": "MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSLFAASAGSFGGPHGHTDAAGHLLFPGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPSTDNPTTSSLSPSSSAVHHTAGHSALSSNFNECLWQRKLKVVEEGKTTKKDRGG", "length": 466, "header": "tr|F1N389-1|F1N389_BOVIN Isoform 1 of Zic family member 1 OS=Bos taurus OX=9913 GN=ZIC1 PE=3 SV=4 CANONICAL=F1N389-1" }, "locus": { "chromosome": "1", "start_pos": 120900384, "end_pos": 120891412, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019626.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019626.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019626.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019626.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N389", "url": "https://www.uniprot.org/uniprotkb/F1N389" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N389-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 466, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N389-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N389" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N389" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 274, "end_pos": 301, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 243, "end_pos": 245 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N390-1", "uniprot_ac": "F1N390", "uniprot_id": "F1N390_BOVIN", "mass": { "chemical_mass": 47084.0, "monoisotopic_mass": 47084.0 }, "refseq": { "ac": "NP_001192961", "name": "cation channel sperm-associated protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192961" }, "gene_names": [ { "name": "CATSPER3", "type": "recommended", "evidence": [ { "id": "F1N390", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ] }, { "name": "CATSPER3", "type": "synonym", "evidence": [ { "id": "NP_001192961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192961" } ] } ], "protein_names": [ { "name": "Cation channel sperm associated 3", "type": "synonym", "evidence": [ { "id": "F1N390", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N390/entry#names_and_taxonomy" } ] }, { "name": "cation channel sperm-associated protein 3", "type": "synonym", "evidence": [ { "id": "NP_001192961", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192961" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CATSPER3", "url": "https://www.uniprot.org/uniprotkb/F1N390", "locus": { "chromosome": "7", "start_pos": 46456157, "end_pos": 46424173, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014746", "url": "https://www.ensembl.org/id/ENSBTAG00000014746" } ] } } ], "crossref": [ { "id": "F1N390", "url": "https://alphafold.ebi.ac.uk/entry/F1N390", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014746", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014746", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540820", "url": "https://www.ncbi.nlm.nih.gov/gene/540820", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540820", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540820", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YETMAVY", "url": "https://omabrowser.org/oma/group/YETMAVY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N390", "url": "https://www.orthodb.org/?gene=F1N390", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47131:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47131:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1300642", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300642", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192961", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N390-1", "url": "https://www.uniprot.org/uniprotkb/F1N390-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQHFYHQDHARILSNSLLENASHMFYEKLWKFQRKDTQFQAFVKKVIMSHLFKIIMISTISMNAFFMVLWTDYKTRYNLFRLFEVSELIFVSIYTSEFCMKLYVDPISYWKDGYNLLDVVIIIIIFIPYSLRKIKGKHYPYLNIADGVQSLRILKLITYSRGIRTLITAMGQTAYTVASVLILFFVLMYIFAILGFCLFGLPEGGDMNNWGNLALAFFTLFSLATVDGWTDLQEQLDARNLILSRSFTIIFILLASFVFLSMFVGVMIIHTEDSIKKFERELMLERRMNLMEEKQVILKRQQEEVSKLMQTQKDLDHKSFTELVEKFKKTLRHTDPMVLDDFGTSLPFIDIYLSTLDNQDATIYKLQELYYEIVHVLSLMLEDLPQKKQSKSSEKVDEK", "length": 400, "header": "tr|F1N390-1|F1N390_BOVIN Isoform 1 of Cation channel sperm associated 3 OS=Bos taurus OX=9913 GN=CATSPER3 PE=4 SV=2 CANONICAL=F1N390-1" }, "isoforms": [ { "isoform_ac": "F1N390-1", "url": "https://www.uniprot.org/uniprotkb/F1N390/entry", "sequence": { "sequence": "MSQHFYHQDHARILSNSLLENASHMFYEKLWKFQRKDTQFQAFVKKVIMSHLFKIIMISTISMNAFFMVLWTDYKTRYNLFRLFEVSELIFVSIYTSEFCMKLYVDPISYWKDGYNLLDVVIIIIIFIPYSLRKIKGKHYPYLNIADGVQSLRILKLITYSRGIRTLITAMGQTAYTVASVLILFFVLMYIFAILGFCLFGLPEGGDMNNWGNLALAFFTLFSLATVDGWTDLQEQLDARNLILSRSFTIIFILLASFVFLSMFVGVMIIHTEDSIKKFERELMLERRMNLMEEKQVILKRQQEEVSKLMQTQKDLDHKSFTELVEKFKKTLRHTDPMVLDDFGTSLPFIDIYLSTLDNQDATIYKLQELYYEIVHVLSLMLEDLPQKKQSKSSEKVDEK", "length": 400, "header": "tr|F1N390-1|F1N390_BOVIN Isoform 1 of Cation channel sperm associated 3 OS=Bos taurus OX=9913 GN=CATSPER3 PE=4 SV=2 CANONICAL=F1N390-1" }, "locus": { "chromosome": "7", "start_pos": 46455508, "end_pos": 46424173, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019622.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019622.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019622.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019622.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540820", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540820", "resource": "KEGG Pathway" }, { "id": "R-BTA-1300642", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300642", "resource": "Reactome", "description": "Sperm Motility And Taxes" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LZS9-1", "protein_name": "Cation channel, sperm associated 3", "gene_name": "Catsper3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQYFHHNPVRVKSSSLFGTASVALHAKLSQYKRRDKQCQAFFRKVTKSTLFQILMITTVTANSFLLVLGTNYDIHFRMFRVFEISELFFVSIYACEFLMKVYVDPITYWKDGYNILDVVILVIITIPYFLRKIKGNHFEYLHFADGIQSLRVLKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFGNADRGDLTNWGNLAAAFFTLFSLATVDGWTNLQEELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSIKKFEREMTLERNLALMEEKQMILRRQQDEVNRLMNTQKVGGKSFVEMVEGFKRTLRHTDPMVLDEFCTSLSFIDIYLDTLDNQDVIVSKLQELYYEIANVLNLMLEDMPPREKSSSTLES", "length": 395 }, "evidence": [ { "id": "F1N390", "url": "https://omabrowser.org/oma/group/F1N390/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LPB0-1", "protein_name": "Cation channel sperm associated 3", "gene_name": "CATSPER3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSQHLNHQNHTQVTSSSLLENASLMFHEKIWKFQRKDTQCQAFVKSVVTSRLFKIMMISTVSMNAFFMVLWTDYKTRYNLFRLFEVSEVIFVSVYSSEFCMKLYVDPVAYWRDGYNLLDVIILAILFVPYGLRKVKGKHYPYLNIADGMQSLRILKLITYSRGIRTLLTAVGQTVYTVASVLILFFVLMFIFAILGFCLFGAPERGDLNNWGNLALAFFTLFSLATVDGWTDLQQQLDDRNFVLSRTFTITFILLASFIFLSMFVGVMITHTEDSIKKFERELMLERHVTVMEEKQVILKRQQEEVSRLVQTQKNVDHKSFAELVENFKKTLRHTDPMVLDDFGTSLPFIDVYLSTLDNQDATVSKLQELYYEIVHVLSLILEDLPQKKQSQSSEKVDER", "length": 400 }, "evidence": [ { "id": "F1N390", "url": "https://omabrowser.org/oma/group/F1N390/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80W99-1", "protein_name": "Cation channel sperm-associated protein 3", "gene_name": "Catsper3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQHFHHNPVRVKSGSLFATASEALQARLSKIKRKDKECQAYFRKVIKSTFFQIVMITTVTTNSFLLVLGTNYDIQFEFFRTFEVSELFFVSVYVCEFLMKVYVDPITYWKDGYNILDVIILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFGVTDRGDLENWGNLASAFFTLFSLATVDGWTDLQEELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSMKKFERDLTLERNLAIMEEKQIILKRQQEEVNRLMNTQKSGSMNFIDMVEGFKKTLRHTDPMVLDDFSTSLSFIDIYLVTLDNQDVIVSKLQELYCEIVNVLSLMLEDMPKESSSSLSGLS", "length": 395 }, "evidence": [ { "id": "F1N390", "url": "https://omabrowser.org/oma/group/F1N390/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86XQ3-1", "protein_name": "Cation channel sperm-associated protein 3", "gene_name": "CATSPER3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK", "length": 398 }, "evidence": [ { "id": "F1N390", "url": "https://omabrowser.org/oma/group/F1N390/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" }, { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "voltage-gated calcium channel activity", "id": "GO:0005245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005245", "evidence": [ { "database": "UniProtKB", "id": "F1N390", "url": "https://www.uniprot.org/uniprotkb/F1N390" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N390-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N390-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N390" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N390", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N390" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 269, "start_aa": "His", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 21, "end_pos": 23 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3B0-1", "uniprot_ac": "F1N3B0", "uniprot_id": "F1N3B0_BOVIN", "mass": { "chemical_mass": 57960.0, "monoisotopic_mass": 57960.0 }, "refseq": { "ac": "XP_005215189", "name": "nicotinate phosphoribosyltransferase isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215189" }, "gene_names": [ { "name": "NAPRT", "type": "recommended", "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ] }, { "name": "NAPRT1", "type": "synonym", "evidence": [ { "id": "XP_005215189", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215189" } ] }, { "name": "NAPRT", "type": "synonym", "evidence": [ { "id": "XP_005215189", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215189" } ] } ], "protein_names": [ { "name": "Nicotinate phosphoribosyltransferase", "type": "recommended", "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0/entry#names_and_taxonomy" } ] }, { "name": "6.3.4.21", "type": "synonym", "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0/entry#names_and_taxonomy" } ] }, { "name": "nicotinate phosphoribosyltransferase isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005215189", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215189" } ] } ], "function": [ { "annotation": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0#function" }, { "database": "UniProtKB", "id": "ARBA00023426", "url": "https://www.uniprot.org/uniprotkb/ARBA00023426#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAPRT", "url": "https://www.uniprot.org/uniprotkb/F1N3B0", "locus": { "chromosome": "14", "start_pos": 1130654, "end_pos": 1127505, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014642", "url": "https://www.ensembl.org/id/ENSBTAG00000014642" } ] } } ], "crossref": [ { "id": "F1N3B0", "url": "https://alphafold.ebi.ac.uk/entry/F1N3B0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014642", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014642", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01570", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01570", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "399559", "url": "https://www.ncbi.nlm.nih.gov/gene/399559", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007229", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007229", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041619", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041619", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VYFPGSP", "url": "https://omabrowser.org/oma/group/VYFPGSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3B0", "url": "https://www.orthodb.org/?gene=F1N3B0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11098:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11098:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17767", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17767", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215189", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215189", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36163", "url": "https://www.rhea-db.org/rhea/36163", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3B0-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEQDPEGRAAARPLLTDLYQATMALGYWRAGRAQDQAEFELFFRQCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASALPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPDKRLLEMGLRRAQGPDGGLTASTYSYLGGFDASSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGQGSQVDLAASVEMWLERVCGHLGLGVQEPHRGERAAFVAYALAFPRAFQGLLDTYSVRRSGLPNFLAVALALQELGYQAVGVRLDSGDLLQQAREIRGVFWTAAAQFGVPWLQSVPIAVSNNIDEEELARLAQKGSEVNVIGIGTSVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLLDVLQLAEEPPPQADQELRVWPRGARESRTVRPAHVEPLLRLWVQQGQLCEPLPSLAESRAFAQQSLHRLSPAHRRLEQPALYQVALSEKLQALVDRLSARGAL", "length": 538, "header": "tr|F1N3B0-1|F1N3B0_BOVIN Isoform 1 of Nicotinate phosphoribosyltransferase OS=Bos taurus OX=9913 GN=NAPRT PE=3 SV=1 CANONICAL=F1N3B0-1" }, "isoforms": [ { "isoform_ac": "F1N3B0-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B0/entry", "sequence": { "sequence": "MAAEQDPEGRAAARPLLTDLYQATMALGYWRAGRAQDQAEFELFFRQCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASALPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPDKRLLEMGLRRAQGPDGGLTASTYSYLGGFDASSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGQGSQVDLAASVEMWLERVCGHLGLGVQEPHRGERAAFVAYALAFPRAFQGLLDTYSVRRSGLPNFLAVALALQELGYQAVGVRLDSGDLLQQAREIRGVFWTAAAQFGVPWLQSVPIAVSNNIDEEELARLAQKGSEVNVIGIGTSVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSLLLDVLQLAEEPPPQADQELRVWPRGARESRTVRPAHVEPLLRLWVQQGQLCEPLPSLAESRAFAQQSLHRLSPAHRRLEQPALYQVALSEKLQALVDRLSARGAL", "length": 538, "header": "tr|F1N3B0-1|F1N3B0_BOVIN Isoform 1 of Nicotinate phosphoribosyltransferase OS=Bos taurus OX=9913 GN=NAPRT PE=3 SV=1 CANONICAL=F1N3B0-1" }, "locus": { "chromosome": "14", "start_pos": 1130603, "end_pos": 1127518, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019496.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019496.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019496.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019496.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q55G10-1", "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "naprt", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQSNTPLKRKKTENGYSENGSTTGATSNQIRELKRATTVDYVYRDQESKDKIKPLNGFVTPLLTDLYQITMAYSLWKNNRHEIPAVFDLYFRKSPFGGEFTVFAGLEEVIRFVSDFHYTKEEVGFIKEMIPDCEQEFLDYLSKLDSSSVTLYAMKEGSVVFPRVPLLRVEGPMILCQLFETTLLCLVNFASLVATNAARHRLAVGKEKVMLEFGLRRAQGPDGAMSASRYSYLGGADGTSNVLAHCFFGIPIRGTHAHSFITNYSGPDELLDASIKDTNGNVHNLLEMSQKYRDELGYTATNLSELVAFVAYARTFPNGLVALVDTYDTLASGVPNFICVALALHQLGYKAVGIRLDSGDLSYLSKASRKLFKQIGEQFKIDYFEKFSIVASNDLNEPTIIALNRQGHEIDVFAIGTNLVTCQAQPALGCVYKLVEINGSPRIKLSQEANKITLPGRKTAYRLFGSEGHPLVDLLVDDNDMIKDGSKQIPQVGKKVLCLHPFEEQKRVIVTPVQIEKLHHIVFEKGQLTMPLPALNDIREYCFQQISKVREDHLRNSNPTPYKVSVTKELFDTLHNLWLDSVPIKEMK", "length": 589 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6P3H4-1", "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "naprt", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATSNEAGSVLNRVPPLLTDLYQMAYAYWRAGRHNEPAVFELFFRDNPFGGGFSLFAGLSDCLLFLQNFSFSDDDVQYLRSVLPADTDAGFFSYLKELDCSCVSVSAVPEGSVVFARVPLLEVSGPLAVVQLLETSLLCLVNYASLVCSNAARFRLAAGPRRRLMEMGLRRAQGPDGGLTASRYTYIGGFDLTSNALAGRLYGIPVAGTMAHSYITSFSSLEEVWPQTLKPCGGGDSIDFICLVKGLLGRVCQLLGSKTNLIREGELAAFLSYAIAYPQNFLPVIDSYSVRCSGLLCFCAVALALFELQYRPLGVRLDSGDLCRQSLDVRRVFRECSKHFSVPQFESLIIVGTNSISEQSLSELNKKDNEIDVVGVGTHLVTCTRQPSLGCVYKLVEVRGRPRMKLSEDPEKSTLPGRKAVYRLLDADGHPQMDVLCLCDEAAPAAGVELQCFSLLGNSTLQCSITPAQVSSLRTQVFSCGQITLPLNSASESRERAQISLQMLNPYHKRLQEPHNYTVALSERLHSLVSDIKKGNSKGSNFLLSN", "length": 546 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6XQN1-1", "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "Naprt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEMELDDQGRMVVRPLLTDLYQATMGLGYWRAGRACEEAEFELFFRHCPFGGSFALTAGLQDCIRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCSRVSVRALPEGSLAFPGVPLLQVSGPLLLVQLLETPLLCLVSYASLVATNAARLRLIAGPDKRLLEMGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFITSFLGSEVPPDPMLAPASSEGPAVDLPASVNLWLKHVCIYLGLEEREPHLGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAKEIRGIFRTVGAEFQMPWLEFVPIAVSNNIDEKELARLAQKGSEVNVIGIGTNVVTCPKQPSMGCVYKLVSVGGQPRIKLTEESQKETLPGSKAAFRFLVSEGSLLLDLLQLAEEPPPKAGQELRVWLQGAQEPCTVKPAQVEPLLRLYLQQGQPYEPLPSLEESRAFAQQSLSRLRPAHKQLQNPAVYQVALSEKLRALVDSLSARGAL", "length": 538 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6XQN6-1", "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "NAPRT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAEQDPEARAAARPLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCAGQSP", "length": 538 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q84WV8-1", "protein_name": "Nicotinate phosphoribosyltransferase 2", "gene_name": "NAPRT2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEPKENGSELGQKIIDGPTNPMVTPLLNDLYQFTMAYAYWKAGKHNERSVFDLYFRKNPFGGEYTVFAGLEECVKFLANFKLTDEEIDFVQECLPGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVVQLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGFDATSNVAAGKLFGIPLRGTHSHAYVSSFMSTDEIVDKVLRSADGKTTCEDFVSHVQTWLKKIQYSPSLSGIFSETNQSELAAFTSYALAFPKTFLALVDTYDVMKSGIPNFCAVALALNDFGYKALGIRLDSGDLAYLSREARNFFCTVERELKVPGFGKMVVTASNDLNEETIDALNKQGHEVDAFGIGTYLVTCYSQAALGCVFKLVEINNQPRIKLSEDVTKVSIPCKKRSYRLYGKEGYPLVDIMTGENEPPPKVGERLLCRHPFNESKRAYVVPQRVEELLKCYWRGSADEAREVLPPLKEIRDRCIKQLENMRPDHMRRLNPTPYKVSVSAKLYDFIHFLWLNEAPVGELQ", "length": 557 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8CC86-1", "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "Naprt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMELDSEGRMVVRPLLTDLYQATMALGYWRAGRACEAAEFELFFRHCPFGGSFALSAGLQDCMRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVPLLQVSGPLLLVQLLETPLLCLVSYASLVATNAARLRLIAGPDKKLLEMGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPASSEGPTVDLPARVNLWLKRVCLYLGLEEQEPHPGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAKEIRGIFRTAGAQFQMPWLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMGCVYKLVSVGGQPRIKLTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAGQELRVWPRGTQEPCTVKPAQVEPLLRLYLQQGQLCEPLPSLDESRRFAQQSLSLLRPAHKQLQSPAVYPVALSEKLRALVDSLSARGPL", "length": 538 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VQX4-1", "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "Naprt", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNDRELGCAGGQFMDRGRMNQNGVVQPLLTDLYQITMAYAYWKSDKTDDTAVFDLFFRNNPFHGEFTIFAGLEECLKFLDSFHYSQSDIEYLKQTLPEGIEHEFFEYLGNLTARDVTLYAIDEGTVAFPRVPIIKIEGPLIIVQLLETTLLTLVNYASLMATNAARYRMVAGKHVKLLEFGLRRAQGPDGGLSASKYSYTGGFDGTSNVLAGKLFNIPVKGTHAHAYITSFSSIGELKTRLIKHKQTGILEDLLEHAVRHRALLSHLLDVSTEESSEGELAAMVSYAIAFPDGFMALVDTYDVKRSGLLNFSAVALALNDLGYHALGIRIDSGDLAYLSCLARETFEKVAERFKVPWFNKLTIVASNDINEDTILSLNEQGHKIDCFGIGTHLVTCQRQPALGCVYKLVEINGQPRIKLSQDVEKVTMPGNKNAYRLYSADGHALIDLLQKVSEPPPAVGQKVLCRHPFQESKRAYVIPSHVESLYKVYWKSGKICQQLPTLEQVREKVQISLKTLRNDHKRTLNPTPYKVAVSDNLYNFIHDLWLQNAPIGELS", "length": 555 }, "evidence": [ { "id": "F1N3B0", "url": "https://omabrowser.org/oma/group/F1N3B0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "pmid": "" }, { "name": "NAD+ biosynthetic process via the salvage pathway", "id": "GO:0034355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034355", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "pmid": "" }, { "name": "nicotinate phosphoribosyltransferase activity", "id": "GO:0004516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004516", "evidence": [ { "database": "UniProtKB", "id": "F1N3B0", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36163", "name": "", "equation": "5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3B0-1", "A5PK51-1" ], "evidence": [ { "id": "36163", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36163" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A5PK51", "gene_name": "NAPRT", "activity": [ { "ec_number": "6.3.4.21", "activity": "5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.", "evidence": [ { "id": "A5PK51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PK51" } ] }, { "ec_number": "6.3.4.21", "activity": "", "evidence": [ { "id": "A5PK51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PK51" } ] } ] }, { "uniprot_ac": "F1N3B0", "gene_name": "NAPRT", "activity": [ { "ec_number": "6.3.4.21", "activity": "5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.", "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ] }, { "ec_number": "6.3.4.21", "activity": "", "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3B0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 538, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3B0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3B0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" }, { "id": "PF17956", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17956" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nicotinate phosphoribosyltransferase C-terminal", "eco_id": "ECO_0000259", "start_pos": 421, "end_pos": 528, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B0" }, { "id": "PF17767", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17767" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nicotinate phosphoribosyltransferase N-terminal", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 143, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.4.21", "ec_name": "5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.", "evidence": [ { "id": "6.3.4.21", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21" }, { "id": "6.3.4.21", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.21" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3B5-1", "uniprot_ac": "F1N3B5", "uniprot_id": "F1N3B5_BOVIN", "mass": { "chemical_mass": 41824.0, "monoisotopic_mass": 41824.0 }, "refseq": {}, "gene_names": [ { "name": "VSX2", "type": "recommended", "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ] } ], "protein_names": [ { "name": "Visual system homeobox 2", "type": "recommended", "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5/entry#names_and_taxonomy" } ] }, { "name": "Ceh-10 homeodomain-containing homolog", "type": "synonym", "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5/entry#names_and_taxonomy" } ] }, { "name": "Homeobox protein CHX10", "type": "synonym", "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VSX2", "url": "https://www.uniprot.org/uniprotkb/F1N3B5", "locus": { "chromosome": "10", "start_pos": 85619777, "end_pos": 85599406, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014632", "url": "https://www.ensembl.org/id/ENSBTAG00000014632" } ] } } ], "crossref": [ { "id": "F1N3B5", "url": "https://alphafold.ebi.ac.uk/entry/F1N3B5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014632", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3B5", "url": "https://www.orthodb.org/?gene=F1N3B5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46892", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46892", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46892:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46892:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3B5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGKAGEALNKPKAETVAKSTSGSAPARCTGFGIQEILGLNKEPPSSHPRATLDGLAPGHLLAARSVLSPAGVGGMGLLGPGGLPGFYAQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLVQDGFPRRFSKPEYQQFFLGMHKKSLEAAAESGRKPEAERQALPKLNKTEPEERGTEPPAAMSQEELRENSIAALRARAQEHSTKVLGTVSGPDGLVRGAEEPEREEAADEDRPAERLSPARLEDVA", "length": 381, "header": "tr|F1N3B5-1|F1N3B5_BOVIN Isoform 1 of Visual system homeobox 2 OS=Bos taurus OX=9913 GN=VSX2 PE=3 SV=3 CANONICAL=F1N3B5-1" }, "isoforms": [ { "isoform_ac": "F1N3B5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B5/entry", "sequence": { "sequence": "MTGKAGEALNKPKAETVAKSTSGSAPARCTGFGIQEILGLNKEPPSSHPRATLDGLAPGHLLAARSVLSPAGVGGMGLLGPGGLPGFYAQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLVQDGFPRRFSKPEYQQFFLGMHKKSLEAAAESGRKPEAERQALPKLNKTEPEERGTEPPAAMSQEELRENSIAALRARAQEHSTKVLGTVSGPDGLVRGAEEPEREEAADEDRPAERLSPARLEDVA", "length": 381, "header": "tr|F1N3B5-1|F1N3B5_BOVIN Isoform 1 of Visual system homeobox 2 OS=Bos taurus OX=9913 GN=VSX2 PE=3 SV=3 CANONICAL=F1N3B5-1" }, "locus": { "chromosome": "10", "start_pos": 85618773, "end_pos": 85599605, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019481.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019481.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019481.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019481.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "F1N3B5", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3B5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 381, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3B5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3B5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" }, { "id": "PS51496", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51496" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CVC", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 281, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 146, "end_pos": 207, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B5" }, { "id": "PS50803", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50803" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OAR", "eco_id": "ECO_0000259", "start_pos": 324, "end_pos": 337, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 301, "end_pos": 303 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3B7-1", "uniprot_ac": "F1N3B7", "uniprot_id": "F1N3B7_BOVIN", "mass": { "chemical_mass": 61805.0, "monoisotopic_mass": 61805.0 }, "refseq": { "ac": "NP_001019730", "name": "beta,beta-carotene 15,15'-dioxygenase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" }, "gene_names": [ { "name": "BCO1", "type": "recommended", "evidence": [ { "id": "F1N3B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ] }, { "name": "BCMO1", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] }, { "name": "BCO1", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] }, { "name": "betaCO", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] } ], "protein_names": [ { "name": "Beta-carotene oxygenase 1", "type": "synonym", "evidence": [ { "id": "F1N3B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B7/entry#names_and_taxonomy" } ] }, { "name": "beta,beta-carotene 15,15'-dioxygenase", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] }, { "name": "beta,beta-carotene 15,15'-monooxygenase", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] }, { "name": "beta-carotene 15, 15-monooxygenase 1", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] }, { "name": "beta-carotene 15,15'-monooxygenase 1", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] }, { "name": "beta-carotene-15,15'-oxygenase", "type": "synonym", "evidence": [ { "id": "NP_001019730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ] } ], "function": [ { "annotation": "Cloning and expression of beta-carotene-15,15'-oxygenase; expression shown in granulosa cells and the corpus luteum in the ovary and in germinal and interstitial cells in the testis", "evidence": [ { "database": "RefSeq", "id": "NP_001019730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" }, { "database": "PubMed", "id": "16711651", "url": "https://glygen.org/publication/PubMed/16711651" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCO1", "url": "https://www.uniprot.org/uniprotkb/F1N3B7", "locus": { "chromosome": "18", "start_pos": 7929443, "end_pos": 7897583, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001026", "url": "https://www.ensembl.org/id/ENSBTAG00000001026" } ] } } ], "crossref": [ { "id": "F1N3B7", "url": "https://alphafold.ebi.ac.uk/entry/F1N3B7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001026", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001026", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534696", "url": "https://www.ncbi.nlm.nih.gov/gene/534696", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10543", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10543", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10543:SF132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10543:SF132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3B7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIIFGRNKKEQLEPVRARVTGKIPAWLQGILLRNGPGMHTVGETRYNHWFDGLALLHSFTIRDGEVYYRSKYLRSDTYTANIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMRCGEDFYATTETSYIRRINPQTLETLEKVDFRKYVAVNLATSHPHYDAAGNVLNVGTSIVDKGKTKYVIFKIPAPVPGGRKEGRSPLKDTEVFCSIAAHSLLSPSYYHSFGVSENYIIFLEQPFKLDILKMATAYIRGVSWASCLAFHGEDKTHIHIIDRRTRKPVPTKYHTDPMVVFHHVNAYEEDGCLLFDVITYEDGSLYQLFYLANLNEDFKENSRLTSMPTLKRFVLPLHVDKNAEVGSNLIKLSSTTARALKEKDDQVYCQPELLCEGLELPHINYAHNGQPYRYIFAAGVQWSPIPTKIIKYDILTKSSLTWREEHCWPAEPLFVPTPGAKDEDDGIILSAIVSTDPQKSPFLLVLDARTFTELARASVDVEMHLDFHGLFIPDAGRDPGKQAPSQEAPARAAAGRAAPRT", "length": 547, "header": "tr|F1N3B7-1|F1N3B7_BOVIN Isoform 1 of Beta-carotene oxygenase 1 OS=Bos taurus OX=9913 GN=BCO1 PE=3 SV=5 CANONICAL=F1N3B7-1" }, "isoforms": [ { "isoform_ac": "F1N3B7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3B7/entry", "sequence": { "sequence": "MEIIFGRNKKEQLEPVRARVTGKIPAWLQGILLRNGPGMHTVGETRYNHWFDGLALLHSFTIRDGEVYYRSKYLRSDTYTANIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMRCGEDFYATTETSYIRRINPQTLETLEKVDFRKYVAVNLATSHPHYDAAGNVLNVGTSIVDKGKTKYVIFKIPAPVPGGRKEGRSPLKDTEVFCSIAAHSLLSPSYYHSFGVSENYIIFLEQPFKLDILKMATAYIRGVSWASCLAFHGEDKTHIHIIDRRTRKPVPTKYHTDPMVVFHHVNAYEEDGCLLFDVITYEDGSLYQLFYLANLNEDFKENSRLTSMPTLKRFVLPLHVDKNAEVGSNLIKLSSTTARALKEKDDQVYCQPELLCEGLELPHINYAHNGQPYRYIFAAGVQWSPIPTKIIKYDILTKSSLTWREEHCWPAEPLFVPTPGAKDEDDGIILSAIVSTDPQKSPFLLVLDARTFTELARASVDVEMHLDFHGLFIPDAGRDPGKQAPSQEAPARAAAGRAAPRT", "length": 547, "header": "tr|F1N3B7-1|F1N3B7_BOVIN Isoform 1 of Beta-carotene oxygenase 1 OS=Bos taurus OX=9913 GN=BCO1 PE=3 SV=5 CANONICAL=F1N3B7-1" }, "locus": { "chromosome": "18", "start_pos": 7928284, "end_pos": 7897717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048748.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048748.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045735.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045735.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 463, "start_aa": "Thr", "end_pos": 463, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr463", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning of the bovine beta-carotene-15,15'-oxygenase and expression in gonadal tissues.", "journal": "International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition", "date": "2006-01", "authors": "Morales Adriana, Rosas Antonio, Gonz\u00e1lez Adriana, Antaramian Anaid, Varela-Echavarria Alfredo, Shimada Armando, Mora Ofelia", "evidence": [ { "database": "RefSeq", "id": "NP_001019730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019730" } ], "reference": [ { "type": "PubMed", "id": "16711651", "url": "https://glygen.org/publication/PubMed/16711651" } ] } ], "pathway": [ { "id": "R-BTA-975634", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "resource": "Reactome", "description": "Retinoid metabolism and transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ], "pmid": "" }, { "name": "beta-carotene 15,15'-dioxygenase activity", "id": "GO:0003834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003834", "evidence": [ { "database": "UniProtKB", "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ], "pmid": "" }, { "name": "carotenoid dioxygenase activity", "id": "GO:0010436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010436", "evidence": [ { "database": "UniProtKB", "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "retinal metabolic process", "id": "GO:0042574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042574", "evidence": [ { "database": "UniProtKB", "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ], "pmid": "" }, { "name": "carotene catabolic process", "id": "GO:0016121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016121", "evidence": [ { "database": "UniProtKB", "id": "F1N3B7", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3B7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 547, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3B7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3B7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "F1N3B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" }, { "id": "PIRSR604294-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604294-1" } ], "binding_site_uniprot": 172, "amino_acid": "His", "chebi_lig_id": "CHEBI:24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 172, "end_pos": 172, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" }, { "id": "PIRSR604294-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604294-1" } ], "binding_site_uniprot": 237, "amino_acid": "His", "chebi_lig_id": "CHEBI:24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 237, "end_pos": 237, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" }, { "id": "PIRSR604294-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604294-1" } ], "binding_site_uniprot": 308, "amino_acid": "His", "chebi_lig_id": "CHEBI:24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 308, "end_pos": 308, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B7" }, { "id": "PIRSR604294-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604294-1" } ], "binding_site_uniprot": 514, "amino_acid": "His", "chebi_lig_id": "CHEBI:24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 514, "end_pos": 514, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 463 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3D2-1", "uniprot_ac": "F1N3D2", "uniprot_id": "F1N3D2_BOVIN", "mass": { "chemical_mass": 81349.0, "monoisotopic_mass": 81349.0 }, "refseq": { "ac": "XP_024844255", "name": "zinc finger protein 280C isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844255" }, "gene_names": [ { "name": "ZNF280C", "type": "recommended", "evidence": [ { "id": "F1N3D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ] }, { "name": "ZNF280C", "type": "synonym", "evidence": [ { "id": "XP_024844255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844255" } ] } ], "protein_names": [ { "name": "Zinc finger protein 280C", "type": "synonym", "evidence": [ { "id": "F1N3D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3D2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 280C isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024844255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844255" } ] } ], "function": [ { "annotation": "May function as a transcription factor.", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2#function" }, { "database": "UniProtKB", "id": "ARBA00003729", "url": "https://www.uniprot.org/uniprotkb/ARBA00003729#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF280C", "url": "https://www.uniprot.org/uniprotkb/F1N3D2", "locus": { "chromosome": "X", "start_pos": 14162555, "end_pos": 14227552, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019885", "url": "https://www.ensembl.org/id/ENSBTAG00000019885" } ] } } ], "crossref": [ { "id": "F1N3D2", "url": "https://alphafold.ebi.ac.uk/entry/F1N3D2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019885", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019885", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785820", "url": "https://www.ncbi.nlm.nih.gov/gene/785820", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025243", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3D2", "url": "https://www.orthodb.org/?gene=F1N3D2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13836", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13836", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25429", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25429", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844255", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844255", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3D2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3D2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDDDTSFQPKDSSKMAELFMECEEEELEPWQKKVETPQEEDDELIFVGAVPGSKSPTSSELDEDSSSPEAAFPRFHPESQSSSPEAAFPRFHPESRSSYNSDMAQNVSKPDFAKNSSQVGLDESSDLPFSWSQNTVPLSQDGSTIYIEGLDETLPKIKHSDIIKIITVNPKTSESVSEINPCASLSLTNCSSATSSYLMWSKGTHTLSTATRTGTFFVRACPKCNVQFNLLDPLKYHMKVCCPDMVDVFMEMIKVELSNIEQNTTGAETGKLIMLVSDFYYGRHEGNFDDDEKTYTTFKCFSCLKVLKNNIRFMNHMKHHLELEKQNTESWENHTTCQHCYRQYPTPFQLQCHIESTHTPLEFSTICKICELSFDTEHILLQHMKDTHKPGEMPYICQVCQFRSSSFTDVETHFRVSHENTKNLLCPFCLKVSRMATPYMNHYMKHQKKGIHRCSQCRLQFLTYKEKLVHKLEHRTFIKPKELEGLPPGTKVTIRASIESLHSGPSTSKSILSSSTSSSTCLQVSPSTSKTTTTGSSPRSNANEYKTREFSATTSTESKPSTSKERAAKCRAKTSYKPKKKRNRRNKISVALKNLRCRGVYTCIECHTKIKDFASHFSLFTRCNFCKYSTNCNKAFVNHMLSSHTSQPAKRVSIFKKRCRTLRGITLVCLKCDFLADSSTLDRMAKHLSQRKTHTCQVIIETLPEGTSAVNPFLPSC", "length": 717, "header": "tr|F1N3D2-1|F1N3D2_BOVIN Isoform 1 of Zinc finger protein 280C OS=Bos taurus OX=9913 GN=ZNF280C PE=4 SV=4 CANONICAL=F1N3D2-1" }, "isoforms": [ { "isoform_ac": "F1N3D2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3D2/entry", "sequence": { "sequence": "MDDDTSFQPKDSSKMAELFMECEEEELEPWQKKVETPQEEDDELIFVGAVPGSKSPTSSELDEDSSSPEAAFPRFHPESQSSSPEAAFPRFHPESRSSYNSDMAQNVSKPDFAKNSSQVGLDESSDLPFSWSQNTVPLSQDGSTIYIEGLDETLPKIKHSDIIKIITVNPKTSESVSEINPCASLSLTNCSSATSSYLMWSKGTHTLSTATRTGTFFVRACPKCNVQFNLLDPLKYHMKVCCPDMVDVFMEMIKVELSNIEQNTTGAETGKLIMLVSDFYYGRHEGNFDDDEKTYTTFKCFSCLKVLKNNIRFMNHMKHHLELEKQNTESWENHTTCQHCYRQYPTPFQLQCHIESTHTPLEFSTICKICELSFDTEHILLQHMKDTHKPGEMPYICQVCQFRSSSFTDVETHFRVSHENTKNLLCPFCLKVSRMATPYMNHYMKHQKKGIHRCSQCRLQFLTYKEKLVHKLEHRTFIKPKELEGLPPGTKVTIRASIESLHSGPSTSKSILSSSTSSSTCLQVSPSTSKTTTTGSSPRSNANEYKTREFSATTSTESKPSTSKERAAKCRAKTSYKPKKKRNRRNKISVALKNLRCRGVYTCIECHTKIKDFASHFSLFTRCNFCKYSTNCNKAFVNHMLSSHTSQPAKRVSIFKKRCRTLRGITLVCLKCDFLADSSTLDRMAKHLSQRKTHTCQVIIETLPEGTSAVNPFLPSC", "length": 717, "header": "tr|F1N3D2-1|F1N3D2_BOVIN Isoform 1 of Zinc finger protein 280C OS=Bos taurus OX=9913 GN=ZNF280C PE=4 SV=4 CANONICAL=F1N3D2-1" }, "locus": { "chromosome": "X", "start_pos": 14218788, "end_pos": 14163559, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026492.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026492.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026492.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026492.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N3D2", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3D2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 717, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3D2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3D2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3D2" }, { "id": "PS00028", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 300, "end_pos": 320, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 115, "end_pos": 117 }, { "start_pos": 189, "end_pos": 191 }, { "start_pos": 263, "end_pos": 265 }, { "start_pos": 333, "end_pos": 335 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3E8-1", "uniprot_ac": "F1N3E8", "uniprot_id": "F1N3E8_BOVIN", "mass": { "chemical_mass": 17414.0, "monoisotopic_mass": 17414.0 }, "refseq": {}, "gene_names": [ { "name": "POLR3K", "type": "recommended", "evidence": [ { "id": "F1N3E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ] } ], "protein_names": [ { "name": "DNA-directed RNA polymerase III subunit RPC10", "type": "recommended", "evidence": [ { "id": "F1N3E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3E8/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase III subunit K", "type": "synonym", "evidence": [ { "id": "F1N3E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3E8/entry#names_and_taxonomy" } ] }, { "name": "RNA polymerase III subunit C11", "type": "synonym", "evidence": [ { "id": "F1N3E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3E8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.", "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8#function" }, { "database": "UniProtKB", "id": "ARBA00054653", "url": "https://www.uniprot.org/uniprotkb/ARBA00054653#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLR3K", "url": "https://www.uniprot.org/uniprotkb/F1N3E8", "locus": { "chromosome": "25", "start_pos": 115711, "end_pos": 118789, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019803", "url": "https://www.ensembl.org/id/ENSBTAG00000019803" } ] } } ], "crossref": [ { "id": "F1N3E8", "url": "https://alphafold.ebi.ac.uk/entry/F1N3E8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10509", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10509", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3E8", "url": "https://www.orthodb.org/?gene=F1N3E8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11239:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11239:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02150", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02150", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3E8-1", "url": "https://www.uniprot.org/uniprotkb/F1N3E8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSYWEPAGHCCTWGRGGGVIIGGLAGGGAGTKGRSERRRSAAAGAAGSAGPVAAMLLFCPGCGNGLIVEEGQRCHRFACNTCPYVHNVTRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAEPCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD", "length": 162, "header": "tr|F1N3E8-1|F1N3E8_BOVIN Isoform 1 of DNA-directed RNA polymerase III subunit RPC10 OS=Bos taurus OX=9913 GN=POLR3K PE=3 SV=2 CANONICAL=F1N3E8-1" }, "isoforms": [ { "isoform_ac": "F1N3E8-1", "url": "https://www.uniprot.org/uniprotkb/F1N3E8/entry", "sequence": { "sequence": "MSYWEPAGHCCTWGRGGGVIIGGLAGGGAGTKGRSERRRSAAAGAAGSAGPVAAMLLFCPGCGNGLIVEEGQRCHRFACNTCPYVHNVTRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAEPCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD", "length": 162, "header": "tr|F1N3E8-1|F1N3E8_BOVIN Isoform 1 of DNA-directed RNA polymerase III subunit RPC10 OS=Bos taurus OX=9913 GN=POLR3K PE=3 SV=2 CANONICAL=F1N3E8-1" }, "locus": { "chromosome": "25", "start_pos": 118590, "end_pos": 116187, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026386.4", "url": "https://www.ensembl.org/id/ENSBTAT00000026386.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026386.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026386.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase activity", "id": "GO:0003899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003899", "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "termination of RNA polymerase III transcription", "id": "GO:0006386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006386", "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "RNA polymerase III complex", "id": "GO:0005666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005666", "evidence": [ { "database": "UniProtKB", "id": "F1N3E8", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3E8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 162, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3E8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3E8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3E8" }, { "id": "PS51133", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51133" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TFIIS-type", "eco_id": "ECO_0000259", "start_pos": 119, "end_pos": 161, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3F7-1", "uniprot_ac": "F1N3F7", "uniprot_id": "F1N3F7_BOVIN", "mass": { "chemical_mass": 45475.0, "monoisotopic_mass": 45475.0 }, "refseq": { "ac": "XP_002693497", "name": "tumor necrosis factor receptor superfamily member 19L isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693497" }, "gene_names": [ { "name": "RELT", "type": "recommended", "evidence": [ { "id": "F1N3F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ] }, { "name": "RELT", "type": "synonym", "evidence": [ { "id": "XP_002693497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693497" } ] } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 19L", "type": "recommended", "evidence": [ { "id": "F1N3F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3F7/entry#names_and_taxonomy" } ] }, { "name": "tumor necrosis factor receptor superfamily member 19L isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002693497", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693497" } ] } ], "function": [ { "annotation": "May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation.", "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7#function" }, { "database": "UniProtKB", "id": "ARBA00057580", "url": "https://www.uniprot.org/uniprotkb/ARBA00057580#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RELT", "url": "https://www.uniprot.org/uniprotkb/F1N3F7", "locus": { "chromosome": "15", "start_pos": 52880817, "end_pos": 52874577, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016494", "url": "https://www.ensembl.org/id/ENSBTAG00000016494" } ] } } ], "crossref": [ { "id": "F1N3F7", "url": "https://alphafold.ebi.ac.uk/entry/F1N3F7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016494", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016494", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13419", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13419", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505716", "url": "https://www.ncbi.nlm.nih.gov/gene/505716", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505716", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505716", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SRCSQKW", "url": "https://omabrowser.org/oma/group/SRCSQKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3F7", "url": "https://www.orthodb.org/?gene=F1N3F7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47397", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47397", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47397:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47397:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12606", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12606", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002693497", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693497", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3F7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3F7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLSPPPWSLSCLLVLLPWPLATATPTAPRQCPPGQEPNLEPGWGTLCRSCPPGTFSASWGSRPCQPHSRCSPRGRLEAQVGTATQDALCGDCQPGWFSPAEAPGVPCWPCSRTPLGGRSCFKRGRRARRGVEVAAGAGGAAETRQPGNSTRAGSPEETAAQYAVIAIVPIFCLMGLLGILVCNLLKRKGYHCTAQKEVGPGPGGGGSGTNPACRPEDASEDTIGVLVRLITEKKENAAALEELLKEYHSRQLVQTSHRPLPRLPPGPPSMPHVCPHRQHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAAAATTPAPRLLPNPARTPKAGAKAGRQGEITILSVGRFRVARIPEQRVSSVASEVKTITEAGPSGGELPNSPRPGLPSEQRALLGSGGSHAKWPKPPAENKAEENRYVVRLSESNLVI", "length": 430, "header": "tr|F1N3F7-1|F1N3F7_BOVIN Isoform 1 of Tumor necrosis factor receptor superfamily member 19L OS=Bos taurus OX=9913 GN=RELT PE=3 SV=2 CANONICAL=F1N3F7-1" }, "isoforms": [ { "isoform_ac": "F1N3F7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3F7/entry", "sequence": { "sequence": "MKLSPPPWSLSCLLVLLPWPLATATPTAPRQCPPGQEPNLEPGWGTLCRSCPPGTFSASWGSRPCQPHSRCSPRGRLEAQVGTATQDALCGDCQPGWFSPAEAPGVPCWPCSRTPLGGRSCFKRGRRARRGVEVAAGAGGAAETRQPGNSTRAGSPEETAAQYAVIAIVPIFCLMGLLGILVCNLLKRKGYHCTAQKEVGPGPGGGGSGTNPACRPEDASEDTIGVLVRLITEKKENAAALEELLKEYHSRQLVQTSHRPLPRLPPGPPSMPHVCPHRQHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAAAATTPAPRLLPNPARTPKAGAKAGRQGEITILSVGRFRVARIPEQRVSSVASEVKTITEAGPSGGELPNSPRPGLPSEQRALLGSGGSHAKWPKPPAENKAEENRYVVRLSESNLVI", "length": 430, "header": "tr|F1N3F7-1|F1N3F7_BOVIN Isoform 1 of Tumor necrosis factor receptor superfamily member 19L OS=Bos taurus OX=9913 GN=RELT PE=3 SV=2 CANONICAL=F1N3F7-1" }, "locus": { "chromosome": "15", "start_pos": 52879813, "end_pos": 52874646, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021927.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021927.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021927.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021927.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505716", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505716", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7K6U7-1", "protein_name": "Tumor necrosis factor receptor superfamily member 19L", "gene_name": "Relt", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRERKRRNLACEGSMSLQGLMMKRTLLHWPLPCLFVLLPWPLATATSITPWLCPPGKEPDLDPGQGTLCRTCPPSTFSASWDSHPCQPHYRCSLRGRLEAQAGTATHDAVCGDCEPGWFGPRGVPHVPCQPCSRAPPKTGGCDESGRRARRGVEVASGASGIGEPRQSGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGFNPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQVVQTSHRPVPRLLPASPSMPHICPHRHHLHTVQGLASLSGSCCSRCSQKKWPEVLLSPEAAAATTPAPTLLPNPSRAPKASAKTGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSGGDLPDSPQPGLPPEQRALLGSGGSHTKWLKPPAENRAEENRYVVRLSESNLVI", "length": 451 }, "evidence": [ { "id": "F1N3F7", "url": "https://omabrowser.org/oma/group/F1N3F7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LK59-1", "protein_name": "Tumor necrosis factor receptor superfamily member 19L", "gene_name": "Relt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRQPHSPAPFCPIPALSTPPGAPRLRVLSAPRAAQSVRRSTSLQGLTMKRTLLCWPLSCLFVLLPWPLATPTPITPWLCPPGTEPDPDPGQGTLCRTCPPGTFSASLDSYPCQPHYRCGLQKRLEAQAGTATHDTVCGDCQRGWFGPQGVPHVPCQPCSKATPSTSDCDGRRARRGVEVAAGANSNGELRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVPRLLPASPSTPHVCPHHHHLHTVQGLASLSGPCCSRCSQKWPEVLLSPEAAAATTPAPTLLPSTSRAPKASAKPGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSESDLPESPQPGLPPEQRALLGSSGSHAKWLKPPAENKAEENRYVVRLSESNLVI", "length": 474 }, "evidence": [ { "id": "F1N3F7", "url": "https://omabrowser.org/oma/group/F1N3F7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BX43-1", "protein_name": "Tumor necrosis factor receptor superfamily member 19L", "gene_name": "Relt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLQGLMMKRTLLCWPLSCLFVLLPWPLATPTPITPWLCPPGKEPDPDPGQGTLCRTCPPGTFSASWNSYPCQPHYRCSLQKRLEAQAGTATHDTMCGDCQHGWFGPQGVPHVPCQPCSKAPPSTGGCDESGRRGRRGVEVAAGTSSNGEPRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVPRLLPASPSIPHICPHHHHLHTVQGLASLSGPCCSRCSQKWPEVLLSPEAAAATTPAPTLLPTASRAPKASAKPGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSEGDLPDSPQPGLPPEQRALLGSGGSHTKWLKPPAENKAEENRYVVRLSESNLVI", "length": 436 }, "evidence": [ { "id": "F1N3F7", "url": "https://omabrowser.org/oma/group/F1N3F7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969Z4-1", "protein_name": "Tumor necrosis factor receptor superfamily member 19L", "gene_name": "RELT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPSLLCRPLSCFLMLLPWPLATLTSTTLWQCPPGEEPDLDPGQGTLCRPCPPGTFSAAWGSSPCQPHARCSLWRRLEAQVGMATRDTLCGDCWPGWFGPWGVPRVPCQPCSWAPLGTHGCDEWGRRARRGVEVAAGASSGGETRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAHKEVGPGPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVSKLPPAPPNVPHICPHRHHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAVAATTPVPSLLPNPTRVPKAGAKAGRQGEITILSVGRFRVARIPEQRTSSMVSEVKTITEAGPSWGDLPDSPQPGLPPEQQALLGSGGSRTKWLKPPAENKAEENRYVVRLSESNLVI", "length": 430 }, "evidence": [ { "id": "F1N3F7", "url": "https://omabrowser.org/oma/group/F1N3F7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ], "pmid": "" }, { "name": "amelogenesis", "id": "GO:0097186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097186", "evidence": [ { "database": "UniProtKB", "id": "F1N3F7", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3F7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 430, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3F7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3F7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3F7" }, { "id": "SM00208", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00208" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TNFR-Cys", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 90, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3G2-1", "uniprot_ac": "F1N3G2", "uniprot_id": "F1N3G2_BOVIN", "mass": { "chemical_mass": 90802.0, "monoisotopic_mass": 90802.0 }, "refseq": {}, "gene_names": [ { "name": "NOP2", "type": "recommended", "evidence": [ { "id": "F1N3G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ] } ], "protein_names": [ { "name": "Nucleolar protein 1", "type": "recommended", "evidence": [ { "id": "F1N3G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G2/entry#names_and_taxonomy" } ] }, { "name": "Nucleolar protein 2 homolog", "type": "synonym", "evidence": [ { "id": "F1N3G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G2/entry#names_and_taxonomy" } ] }, { "name": "Proliferating-cell nucleolar antigen p120", "type": "synonym", "evidence": [ { "id": "F1N3G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G2/entry#names_and_taxonomy" } ] }, { "name": "Proliferation-associated nucleolar protein p120", "type": "synonym", "evidence": [ { "id": "F1N3G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2#function" }, { "database": "UniProtKB", "id": "ARBA00056352", "url": "https://www.uniprot.org/uniprotkb/ARBA00056352#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOP2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2", "locus": { "chromosome": "5", "start_pos": 103856938, "end_pos": 103848170, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014733", "url": "https://www.ensembl.org/id/ENSBTAG00000014733" } ] } } ], "crossref": [ { "id": "F1N3G2", "url": "https://alphafold.ebi.ac.uk/entry/F1N3G2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014733", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014733", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3G2", "url": "https://www.orthodb.org/?gene=F1N3G2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22807", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22807", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22807:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22807:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22458", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22458", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3G2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3G2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRKLDPTKKEKRGPGRKARKQKGAETELAKFLPAGGDENSKRLSSRARKRAAKRRLGSAEAPETNKSPGAKPLPGKLPKGFCKPFGVSAGAVQTPGKKEALSLFNIARGKKRPAPTHSSAEEEEDSEGDGVVNQEDLWGSEDSDAGMIDDYGAGSNSEDEDEDDGEELLPIERAARKQKAQEAVAGDQWSEAETDEEEEEEQVSAESGPREDEESEGGLQINVDEEEPFLLPPAGEVEQDTQAPDLQRVHKRIQDIVGVLRDFGTQREEGRSRSEYLQRLRKDLATYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNAIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSIMVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPTLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSATSTPTNPDLPNVNGQVTPKSESGSPSTKKAGQAKQRLQKQQHPKKSSFQKQNGISKGTDTELSTVSAVTKAQASSKLQDSSQPPETAAVVREPKEAGKLKQHSPKLQSSRKAAFRKQHAPPKAMDTDLPAAPSLSKTQATPKPEDRDQPFGNTTGAEKVKQQVAEQPFKKAAFQKQNGTPKGPKTPTMSSCSSSQPPPAKRRKSQSRGGRQPALTSVDG", "length": 830, "header": "tr|F1N3G2-1|F1N3G2_BOVIN Isoform 1 of Nucleolar protein 1 OS=Bos taurus OX=9913 GN=NOP2 PE=3 SV=2 CANONICAL=F1N3G2-1" }, "isoforms": [ { "isoform_ac": "F1N3G2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3G2/entry", "sequence": { "sequence": "MGRKLDPTKKEKRGPGRKARKQKGAETELAKFLPAGGDENSKRLSSRARKRAAKRRLGSAEAPETNKSPGAKPLPGKLPKGFCKPFGVSAGAVQTPGKKEALSLFNIARGKKRPAPTHSSAEEEEDSEGDGVVNQEDLWGSEDSDAGMIDDYGAGSNSEDEDEDDGEELLPIERAARKQKAQEAVAGDQWSEAETDEEEEEEQVSAESGPREDEESEGGLQINVDEEEPFLLPPAGEVEQDTQAPDLQRVHKRIQDIVGVLRDFGTQREEGRSRSEYLQRLRKDLATYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNAIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSIMVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPTLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSATSTPTNPDLPNVNGQVTPKSESGSPSTKKAGQAKQRLQKQQHPKKSSFQKQNGISKGTDTELSTVSAVTKAQASSKLQDSSQPPETAAVVREPKEAGKLKQHSPKLQSSRKAAFRKQHAPPKAMDTDLPAAPSLSKTQATPKPEDRDQPFGNTTGAEKVKQQVAEQPFKKAAFQKQNGTPKGPKTPTMSSCSSSQPPPAKRRKSQSRGGRQPALTSVDG", "length": 830, "header": "tr|F1N3G2-1|F1N3G2_BOVIN Isoform 1 of Nucleolar protein 1 OS=Bos taurus OX=9913 GN=NOP2 PE=3 SV=2 CANONICAL=F1N3G2-1" }, "locus": { "chromosome": "5", "start_pos": 103856842, "end_pos": 103848530, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019607.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019607.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019607.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019607.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 369, "start_aa": "Thr", "end_pos": 369, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr369", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA (cytosine-C5-)-methyltransferase activity", "id": "GO:0009383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009383", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" }, { "name": "regulation of signal transduction by p53 class mediator", "id": "GO:1901796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901796", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" }, { "name": "ribosomal large subunit assembly", "id": "GO:0000027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000027", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" }, { "name": "rRNA base methylation", "id": "GO:0070475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070475", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA", "id": "GO:0000470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000470", "evidence": [ { "database": "UniProtKB", "id": "F1N3G2", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 788, "end_pos": 790, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3G2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 830, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3G2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3G2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G2" }, { "id": "PS51686", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51686" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM-dependent MTase RsmB/NOP-type", "eco_id": "ECO_0000259", "start_pos": 311, "end_pos": 598, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 369 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 514, "end_pos": 516 }, { "start_pos": 66, "end_pos": 68 }, { "start_pos": 763, "end_pos": 765 }, { "start_pos": 788, "end_pos": 790 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3G5-1", "uniprot_ac": "F1N3G5", "uniprot_id": "F1N3G5_BOVIN", "mass": { "chemical_mass": 47147.0, "monoisotopic_mass": 47147.0 }, "refseq": {}, "gene_names": [ { "name": "TAPBPL", "type": "recommended", "evidence": [ { "id": "F1N3G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ] } ], "protein_names": [ { "name": "Tapasin-related protein", "type": "recommended", "evidence": [ { "id": "F1N3G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G5/entry#names_and_taxonomy" } ] }, { "name": "TAP-binding protein-like", "type": "synonym", "evidence": [ { "id": "F1N3G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G5/entry#names_and_taxonomy" } ] }, { "name": "TAP-binding protein-related protein", "type": "synonym", "evidence": [ { "id": "F1N3G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G5/entry#names_and_taxonomy" } ] }, { "name": "Tapasin-like", "type": "synonym", "evidence": [ { "id": "F1N3G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAPBPL", "url": "https://www.uniprot.org/uniprotkb/F1N3G5", "locus": { "chromosome": "5", "start_pos": 103922269, "end_pos": 103929825, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014728", "url": "https://www.ensembl.org/id/ENSBTAG00000014728" } ] } } ], "crossref": [ { "id": "F1N3G5", "url": "https://alphafold.ebi.ac.uk/entry/F1N3G5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014728", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014728", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05771", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05771", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YPLDAQM", "url": "https://omabrowser.org/oma/group/YPLDAQM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3G5", "url": "https://www.orthodb.org/?gene=F1N3G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3G5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAEGWCLLLCLAFSGAANVAERQWQAVDVVLDCFLMEEGGHHGGFASSENMVKAVLVLRQVPVPDDGSLEGLTDFQVDTLTKDNSLITFEASVNLVQIPQAEALLHADCSGKEVTCEISRYFLQARPEATVEMAAWFITNVQVSGGGPGVSMVMKTLEDAENETVLHPTLKLPLSPQGTVRTAVEFQVTTQTPSLNFLLGSTASLHCGYSVAPGLDVTSVEWRLQHKGSGRLVYHWTMGQGQAKREGATLEPEQLLTAGDASLTLPSLTLQDEGAYICQITTSLFRAQQVIQLYIQASPKVRLSLLNAAPPATLICNVAGYYPLDVSVTWTREEQGGSPAPVSGASLSSLRQSPAGTYSISSSLTVEPGSAGATYTCQVTHVSLEEPLGVHAWVAPPVAEQKSALGVLLASILFVLTLLFLGLQRRQATSPRSPKTSRHSG", "length": 442, "header": "tr|F1N3G5-1|F1N3G5_BOVIN Isoform 1 of Tapasin-related protein OS=Bos taurus OX=9913 GN=TAPBPL PE=4 SV=1 CANONICAL=F1N3G5-1" }, "isoforms": [ { "isoform_ac": "F1N3G5-1", "url": "https://www.uniprot.org/uniprotkb/F1N3G5/entry", "sequence": { "sequence": "MGAEGWCLLLCLAFSGAANVAERQWQAVDVVLDCFLMEEGGHHGGFASSENMVKAVLVLRQVPVPDDGSLEGLTDFQVDTLTKDNSLITFEASVNLVQIPQAEALLHADCSGKEVTCEISRYFLQARPEATVEMAAWFITNVQVSGGGPGVSMVMKTLEDAENETVLHPTLKLPLSPQGTVRTAVEFQVTTQTPSLNFLLGSTASLHCGYSVAPGLDVTSVEWRLQHKGSGRLVYHWTMGQGQAKREGATLEPEQLLTAGDASLTLPSLTLQDEGAYICQITTSLFRAQQVIQLYIQASPKVRLSLLNAAPPATLICNVAGYYPLDVSVTWTREEQGGSPAPVSGASLSSLRQSPAGTYSISSSLTVEPGSAGATYTCQVTHVSLEEPLGVHAWVAPPVAEQKSALGVLLASILFVLTLLFLGLQRRQATSPRSPKTSRHSG", "length": 442, "header": "tr|F1N3G5-1|F1N3G5_BOVIN Isoform 1 of Tapasin-related protein OS=Bos taurus OX=9913 GN=TAPBPL PE=4 SV=1 CANONICAL=F1N3G5-1" }, "locus": { "chromosome": "5", "start_pos": 103929407, "end_pos": 103923358, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019601.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019601.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019601.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019601.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8VD31-1", "protein_name": "Tapasin-related protein", "gene_name": "Tapbpl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLEPSWYLLLCLAVSGAAGTDPPTAPTTAERQRQPTDIILDCFLVTEDRHRGAFASSGDRERALLVLKQVPVLDDGSLEGITDFQGSTETKQDSPVIFEASVDLVQIPQAEALLHADCSGKAVTCEISKYFLQARQEATFEKAHWFISNMQVSRGGPSVSMVMKTLRDAEVGAVRHPTLNLPLSAQGTVKTQVEFQVTSETQTLNHLLGSSVSLHCSFSMAPGLDLTGVEWRLQHKGSGQLVYSWKTGQGQAKRKGATLEPEELLRAGNASLTLPNLTLKDEGNYICQISTSLYQAQQIMPLNILAPPKIQLHLANKDPLPSLVCSIAGYYPLDVGVTWIREELGGIPAQVSGASFSSLRQSTMGTYSISSTVMADPGPTGATYTCQVAHVSLEEPLTTSMRVLPNPEQRGTLGVIFASIIFLSALLLFLGLHRQQASSSRSTRPMRHSG", "length": 451 }, "evidence": [ { "id": "F1N3G5", "url": "https://omabrowser.org/oma/group/F1N3G5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BX59-1", "protein_name": "Tapasin-related protein", "gene_name": "TAPBPL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLAKDGAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANMQVSGGGPSISLVMKTPRVTKNEALWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS", "length": 468 }, "evidence": [ { "id": "F1N3G5", "url": "https://omabrowser.org/oma/group/F1N3G5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "MHC class I protein complex binding", "id": "GO:0023024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023024", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" }, { "name": "TAP complex binding", "id": "GO:0062061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062061", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" }, { "name": "MHC class I peptide loading complex", "id": "GO:0042824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042824", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "peptide antigen assembly with MHC class I protein complex", "id": "GO:0002502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002502", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" }, { "name": "negative regulation of antigen processing and presentation of peptide antigen via MHC class I", "id": "GO:0002590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002590", "evidence": [ { "database": "UniProtKB", "id": "F1N3G5", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3G5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 442, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3G5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3G5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3G5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 177, "end_pos": 293, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3H8-1", "uniprot_ac": "F1N3H8", "uniprot_id": "F1N3H8_BOVIN", "mass": { "chemical_mass": 42724.0, "monoisotopic_mass": 42724.0 }, "refseq": {}, "gene_names": [ { "name": "CTBS", "type": "recommended", "evidence": [ { "id": "F1N3H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ] } ], "protein_names": [ { "name": "Di-N-acetylchitobiase", "type": "recommended", "evidence": [ { "id": "F1N3H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3H8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Reducing-end exoglycosidase involved in glycan degradation. Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) and higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues. During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase.", "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8#function" }, { "database": "UniProtKB", "id": "ARBA00094420", "url": "https://www.uniprot.org/uniprotkb/ARBA00094420#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTBS", "url": "https://www.uniprot.org/uniprotkb/F1N3H8", "locus": { "chromosome": "3", "start_pos": 59524072, "end_pos": 59509795, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005782", "url": "https://www.ensembl.org/id/ENSBTAG00000005782" } ] } } ], "crossref": [ { "id": "F1N3H8", "url": "https://alphafold.ebi.ac.uk/entry/F1N3H8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005782", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005782", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02875", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02875", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KWIMKQV", "url": "https://omabrowser.org/oma/group/KWIMKQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3H8", "url": "https://www.orthodb.org/?gene=F1N3H8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46290:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46290:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "30671", "url": "https://www.rhea-db.org/rhea/30671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "84983", "url": "https://www.rhea-db.org/rhea/84983", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85195", "url": "https://www.rhea-db.org/rhea/85195", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85199", "url": "https://www.rhea-db.org/rhea/85199", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85203", "url": "https://www.rhea-db.org/rhea/85203", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85207", "url": "https://www.rhea-db.org/rhea/85207", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "85211", "url": "https://www.rhea-db.org/rhea/85211", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3H8-1", "url": "https://www.uniprot.org/uniprotkb/F1N3H8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARLQLAGSRRLVPLPRRAPRLAPLLLPLLLALPDGARADCPCKVPALCRPITHRPDFEVFVFNVGHKTWKYYDWSQITTVVLFSNYDPELMCHAHAKGARVVLKGDVPVKDIINATFRASWIAQQVKLAKTQYMDGINLDIEQDVAHSSPEYYALTALVKETTDSFHHEIKGSQVTFDVPWGPNCVGARCYNYTGIADACDFLFVMSYDERCLACSQCIAGANSPYIQTLTGYDDFIKIGINPKKLVMGIPWYGYDFTCQNLSVDHVCTTAKYPCRDAVHHQVTYQKIMKQVNSSTSGRLWDKNQQSPYYHYKDQAGHFHQVWYDDPQSISLKASYVQKRGILGIGMWHANCLDYSGDAIARQQTEEMWKALKPNL", "length": 377, "header": "tr|F1N3H8-1|F1N3H8_BOVIN Isoform 1 of Di-N-acetylchitobiase OS=Bos taurus OX=9913 GN=CTBS PE=3 SV=2 CANONICAL=F1N3H8-1" }, "isoforms": [ { "isoform_ac": "F1N3H8-1", "url": "https://www.uniprot.org/uniprotkb/F1N3H8/entry", "sequence": { "sequence": "MARLQLAGSRRLVPLPRRAPRLAPLLLPLLLALPDGARADCPCKVPALCRPITHRPDFEVFVFNVGHKTWKYYDWSQITTVVLFSNYDPELMCHAHAKGARVVLKGDVPVKDIINATFRASWIAQQVKLAKTQYMDGINLDIEQDVAHSSPEYYALTALVKETTDSFHHEIKGSQVTFDVPWGPNCVGARCYNYTGIADACDFLFVMSYDERCLACSQCIAGANSPYIQTLTGYDDFIKIGINPKKLVMGIPWYGYDFTCQNLSVDHVCTTAKYPCRDAVHHQVTYQKIMKQVNSSTSGRLWDKNQQSPYYHYKDQAGHFHQVWYDDPQSISLKASYVQKRGILGIGMWHANCLDYSGDAIARQQTEEMWKALKPNL", "length": 377, "header": "tr|F1N3H8-1|F1N3H8_BOVIN Isoform 1 of Di-N-acetylchitobiase OS=Bos taurus OX=9913 GN=CTBS PE=3 SV=2 CANONICAL=F1N3H8-1" }, "locus": { "chromosome": "3", "start_pos": 59523590, "end_pos": 59509833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007603.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007603.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007603.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007603.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SAG3-1", "protein_name": "Di-N-acetylchitobiase", "gene_name": "CTBS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARTKLRQHLLVSSALGAPTLARLVLLLLLPLLQAPPLGAEAHCPCHNPALCRPITHKPDFEVFVFDVGHKTWKYYDWSQITTVAFFGNYDSELLCYAHSKGARAVLKGDVSVKDIVNATFRASWIAQQIKQAKTQYMDGINLDIEQDVALSSPEYYALTALVKETTDAFHREIKGSQVTFDVSWSPHCIAQRCYNYTAIADACDFLFVMSYDERSLPWSKCIAGANSPYTQTLTGYDQYINIGINPKKLVMGIPWYGYDYTCKTLSEHHVCTTAKLPCKDAVHRQVPYQIIMKQLNNSYSGSLWDENQKSPYYHYQDQAGNFHQVWYDNPRSISLKAAYVQSHGLLGIGMWHASCLDYSGNALAKQQTEEMWKALKPKL", "length": 380 }, "evidence": [ { "id": "F1N3H8", "url": "https://omabrowser.org/oma/group/F1N3H8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q01459-1", "protein_name": "Di-N-acetylchitobiase", "gene_name": "CTBS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRPQLRRWRLVSSPPSGVPGLALLALLALLALRLAAGTDCPCPEPELCRPIRHHPDFEVFVFDVGQKTWKSYDWSQITTVATFGKYDSELMCYAHSKGARVVLKGDVSLKDIIDPAFRASWIAQKLNLAKTQYMDGINIDIEQEVNCLSPEYDALTALVKETTDSFHREIEGSQVTFDVAWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYNDYIKMSINPKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPFRGAPCSDAAGRQVPYKTIMKQINSSISGNLWDKDQRAPYYNYKDPAGHFHQVWYDNPQSISLKATYIQNYRLRGIGMWNANCLDYSGDAVAKQQTEEMWEVLKPKLLQR", "length": 385 }, "evidence": [ { "id": "F1N3H8", "url": "https://omabrowser.org/oma/group/F1N3H8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q01460-1", "protein_name": "Di-N-acetylchitobiase", "gene_name": "Ctbs", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALSDLLELTLLLLLPLLERLSAEDCPCSEASLCRPIRHHRDFEVFVFDVGQKTWKSYDWSQITTVAVFGKYDSELMCYAHSKGARVVLKGDVALKDIINPTFRASWIAQKVALAKAQHMDGINIDIEQEVDCSSPEYEALTALVRETTEGFHREIEGSQVTFDVAWSPKGIDKRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYGDYLRMGISPRKLVMGIPWYGYDYICLNLSKDDVCAIAKVPFRGAPCSDAAGHQVPYRVIMKQVNSSVSGSQWNQDQQAPYYNYKDPTGRLHQVWYDNPRSISLKAAFVKHYGLRGIGMWNANCLDYSDDALAREQTEEMWGALRPRL", "length": 367 }, "evidence": [ { "id": "F1N3H8", "url": "https://omabrowser.org/oma/group/F1N3H8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R242-1", "protein_name": "Di-N-acetylchitobiase", "gene_name": "Ctbs", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALCGLPEFTLLLLPLLARLSAGDCPCSEAALCQPIRHRPDFEVFVFDVGQKTWKSYDWSQITTVAAFGKYDPELMCYAHSKGARVVLKGDISLKNIIDPTFRASWIAQKVDLAKAQYMDGINIDIEQEVNCSSPEYEALTALVKETTESFQREIEGSQVTFDVAWSPKRIDKRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYIDYIKMGISPKKLVMGVPWYGYDYICLNLSKDDICTITKVPFRGAPCSDAAGHQVPYKVIMKQVNGSVSGSQWNKDQQAPYYNYKDPAGRFHQVWYDNPQSISLKAAYVKNYGLRGIGMWNANCLDYSDDALAREQTQEMWGALKPRL", "length": 366 }, "evidence": [ { "id": "F1N3H8", "url": "https://omabrowser.org/oma/group/F1N3H8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8T293-1", "protein_name": "Probable di-N-acetylchitobiase 2", "gene_name": "ctbs2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MRIILLLFLIVFVVAQSSSSSSSSGCPCDSSYLCEPLQIAPRQEFLGFSLNSTQYPNYYWNQLTTLAIFYETIEDELLCIAHENDVRLVWGTTFPIENLGNSSYIEEWIQEQIEKVQSTFTDGLNFDVESPITDPTIAQQYTELVSATNKAFKAINPFYQISIDVAWSPSCIDKRCYDYAGLASNSDFLVAMDYDERSQVFGEKVCTAGANSSPSNALAGINNFTDLGISTDQLVMGLPWYGYIYKNCLNGDEAGLETVVCQIESVPFRGANCSDAAGSEYDYSYLVQLLQDQTINSSAVQWNTEWQSPYFNYIDPITGNVDQVWFDNPQSLSIKVQLAQKLNLRGVAVWNIDFLDFSDQYNSRPMWDALASFFPQSASSEQSLN", "length": 385 }, "evidence": [ { "id": "F1N3H8", "url": "https://omabrowser.org/oma/group/F1N3H8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chitinase activity", "id": "GO:0004568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004568", "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ], "pmid": "" }, { "name": "chitin binding", "id": "GO:0008061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chitin catabolic process", "id": "GO:0006032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ], "pmid": "" }, { "name": "oligosaccharide catabolic process", "id": "GO:0009313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009313", "evidence": [ { "database": "UniProtKB", "id": "F1N3H8", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "30671", "name": "", "equation": "N,N'-diacetylchitobiose + H2O = 2 N-acetyl-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "30671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30671" } ] }, { "id": "84983", "name": "", "equation": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc + H2O = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N-acetyl-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "84983", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84983" } ] }, { "id": "85195", "name": "", "equation": "alpha-hexa-N-acetylchitohexaose + H2O = beta-penta-N-acetylchitopentaose + N-acetyl-alpha-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "85195", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85195" } ] }, { "id": "85199", "name": "", "equation": "alpha-penta-N-acetylchitopentaose + H2O = beta-tetra-N-acetylchitotetraose + N-acetyl-alpha-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "85199", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85199" } ] }, { "id": "85203", "name": "", "equation": "alpha-tetra-N-acetylchitotetraose + H2O = beta-tri-N-acetylchitotriose + N-acetyl-alpha-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "85203", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85203" } ] }, { "id": "85207", "name": "", "equation": "alpha-tri-N-acetylchitotriose + H2O = beta-di-N-acetylchitobiose + N-acetyl-alpha-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "85207", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85207" } ] }, { "id": "85211", "name": "", "equation": "alpha-di-N-acetylchitobiose + H2O = N-acetyl-beta-D-glucosamine + N-acetyl-alpha-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q01458-1" ], "evidence": [ { "id": "85211", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85211" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q01458", "gene_name": "CTBS", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "Q01458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01458" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3H8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 377, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3H8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3H8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3H8" }, { "id": "PS51910", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51910" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GH18", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 377, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 193, "end_pos": 195 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 294, "end_pos": 296 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3I3-1", "uniprot_ac": "F1N3I3", "uniprot_id": "F1N3I3_BOVIN", "mass": { "chemical_mass": 140387.0, "monoisotopic_mass": 140387.0 }, "refseq": { "ac": "XP_002696213", "name": "(E3-independent) E2 ubiquitin-conjugating enzyme isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696213" }, "gene_names": [ { "name": "UBE2O", "type": "recommended", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "name": "UBE2O", "type": "synonym", "evidence": [ { "id": "XP_002696213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696213" } ] } ], "protein_names": [ { "name": "(E3-independent) E2 ubiquitin-conjugating enzyme", "type": "recommended", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] }, { "name": "(E3-independent) E2 ubiquitin-conjugating enzyme isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002696213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696213" } ] }, { "name": "2.3.2.24", "type": "synonym", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] }, { "name": "E2/E3 hybrid ubiquitin-protein ligase UBE2O", "type": "synonym", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin carrier protein O", "type": "synonym", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin-conjugating enzyme E2 O", "type": "synonym", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin-conjugating enzyme E2 of 230 kDa", "type": "synonym", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitin-protein ligase O", "type": "synonym", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3#function" }, { "database": "UniProtKB", "id": "ARBA00057012", "url": "https://www.uniprot.org/uniprotkb/ARBA00057012#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE2O", "url": "https://www.uniprot.org/uniprotkb/F1N3I3", "locus": { "chromosome": "19", "start_pos": 55348762, "end_pos": 55299781, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020115", "url": "https://www.ensembl.org/id/ENSBTAG00000020115" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020115", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020115", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23837", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23837", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789422", "url": "https://www.ncbi.nlm.nih.gov/gene/789422", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789422", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789422", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVKGFED", "url": "https://omabrowser.org/oma/group/WVKGFED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3I3", "url": "https://www.orthodb.org/?gene=F1N3I3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46116:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46116:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23043", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23043", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23044", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23044", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002696213", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696213", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3I3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPAASAPAAPAPAQIPDVPPSPDAAPASAPAPASAADSGSGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIVYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIACECPEKHCAQGEGSVAKKVKRLLKKQLVRITSCSPDVQCSRDHSMEDAGKKGAAKAKSETGSASPEETPDGSSSPVEMQDEGPEEAHEAGEQLPPFLLKEGGDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNAEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPTAEQPAAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTAEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAVPETERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLERAQALPNGLPKDSSSPEPPAVAELSDFGREEPEDGGLAPGEASQGSDSEGPASAPRDRTEQASEAPPDASVPPSVKPKKRRKSYRSFLPEKSGYPDLGFPLFPLSKGFVKSIRGVLMQFRAALTEAGMPESAGDK", "length": 1287, "header": "tr|F1N3I3-1|F1N3I3_BOVIN Isoform 1 of (E3-independent) E2 ubiquitin-conjugating enzyme OS=Bos taurus OX=9913 GN=UBE2O PE=4 SV=2 CANONICAL=F1N3I3-1" }, "isoforms": [ { "isoform_ac": "F1N3I3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3I3/entry", "sequence": { "sequence": "MADPAASAPAAPAPAQIPDVPPSPDAAPASAPAPASAADSGSGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIVYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIACECPEKHCAQGEGSVAKKVKRLLKKQLVRITSCSPDVQCSRDHSMEDAGKKGAAKAKSETGSASPEETPDGSSSPVEMQDEGPEEAHEAGEQLPPFLLKEGGDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNAEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPTAEQPAAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTAEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAVPETERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLERAQALPNGLPKDSSSPEPPAVAELSDFGREEPEDGGLAPGEASQGSDSEGPASAPRDRTEQASEAPPDASVPPSVKPKKRRKSYRSFLPEKSGYPDLGFPLFPLSKGFVKSIRGVLMQFRAALTEAGMPESAGDK", "length": 1287, "header": "tr|F1N3I3-1|F1N3I3_BOVIN Isoform 1 of (E3-independent) E2 ubiquitin-conjugating enzyme OS=Bos taurus OX=9913 GN=UBE2O PE=4 SV=2 CANONICAL=F1N3I3-1" }, "locus": { "chromosome": "19", "start_pos": 55347758, "end_pos": 55299980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026793.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026793.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026793.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026793.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:789422", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789422", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B778-1", "protein_name": "(E3-independent) E2 ubiquitin-conjugating enzyme", "gene_name": "UBE2O", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADPAAPAPAAPAPAQAPDAAPDAAPALDAVPAPAPAPAPAPDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVMDVSIDCAVKLIGTNCIIYPVNSRDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPARIACECPEKHCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTPCPRDHSVEDAAGKKGGAKAKSETGSTSPEGTPGGSASPEEMQDEGPEEAQEAGEQLPPFLLKEAGDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGASRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECSIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPLPATEPPAAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAAPDAERKEEKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVSRIESWLETHALLERAQALPNGLPKDSSSPEPPAAAELSDFGREEPEDGGLAPGEASQGSDSEGGAQGLASAGRDRTDQTSEAAPDTAVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALIEAGMPQGAEDK", "length": 1296 }, "evidence": [ { "id": "F1N3I3", "url": "https://omabrowser.org/oma/group/F1N3I3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A0W6-1", "protein_name": "(E3-independent) E2 ubiquitin-conjugating enzyme", "gene_name": "Ube2o", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADPAAPAPAPAPAQAQAAAAPTPAAAPAAAPPPAPATDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEDGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVIAQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCTPDAQCSRDHAMEDPDKKGEARAGSEVGSASPEEQLDGSASPVEMQDEGSEELHETGEPLPPFLLKEGGDEGLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTGRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGALPKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVDDEHPKIEDLAAILPTEQPAAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAVPDTERKEDKPEVQSPVKAEWPSETPVLCQQCGGRPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLETHVVLERAQALPNGVPKDSSSLEPQAAAELSDSGREEPEDVGMTPGEASQGSDSEGGAQGPASASREHPEQTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPESTEDK", "length": 1291 }, "evidence": [ { "id": "F1N3I3", "url": "https://omabrowser.org/oma/group/F1N3I3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZPJ3-1", "protein_name": "(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O", "gene_name": "Ube2o", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADPAAPAPAQAQAAAAPTPAAAPAAAAPPPAPATDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGDDDGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSIITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCTPDTQCPRDHSMEDPDKKGEARAGSEIGSASPEEQPDGSASPVEMQDEGSEELQETCEPLPPFLLKEGGDDGLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTGRKKSIPLSIKNLKRKHKRKKNKVTRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGALPKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSSSGASSDEWEDDSDSWETDNGLVDDEHPKIEELAAILPAEQPTAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIAEEEKMEAVPDTERKEEKPEVQSPVKAEWPSETPVLCQQCGGRPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLETHAMQERAQVMPNGALKDSSSLEPMAAAELSDSGREEPEDVGMAPGEASQGSDSEGGAQGPASASRDHTEQTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPESTEDK", "length": 1288 }, "evidence": [ { "id": "F1N3I3", "url": "https://omabrowser.org/oma/group/F1N3I3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C0C9-1", "protein_name": "(E3-independent) E2 ubiquitin-conjugating enzyme", "gene_name": "UBE2O", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADPAAPTPAAPAPAQAPAPAPEAVPAPAAAPVPAPAPASDSASGPSSDSGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGEEEGRGSSGCSEAGGAGHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGTVIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILKLSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSVITQENLGRVKRLGCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRIMSCSPDTQCSRDHSMEDPDKKGESKTKSEAESASPEETPDGSASPVEMQDEGAEEPHEAGEQLPPFLLKEGRDDRLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTSRKKSIPLSIKNLKRKHKRKKNKITRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHIGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGAPHKEDEPSVGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDEWEDDSDSWETDNGLVEDEHPKIEEPPIPPLEQPVAPEDKGVVISEEAATAAVQGAVAMAAPMAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKKLQENLKKTLDNVAIVEEEKMEAVPDVERKEDKPEGQSPVKAEWPSETPVLCQQCGGKPGVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPEGIMVKTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSTGGWRLVNRIESWLETHALLEKAQALPNGVPKASSSPEPPAVAELSDSGQQEPEDGGPAPGEASQGSDSEGGAQGLASASRDHTDQTSETAPDASVPPSVKPKKRRKSYRSFLPEKSGYPDIGFPLFPLSKGFIKSIRGVLTQFRAALLEAGMPECTEDK", "length": 1292 }, "evidence": [ { "id": "F1N3I3", "url": "https://omabrowser.org/oma/group/F1N3I3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9XZ32-1", "protein_name": "UBC core domain-containing protein", "gene_name": "Dmel\\CG10254", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MMSDVAGAAAPGGTPGQPQQEQEQSLAEAAPRTPTLANPPPSSQELGRTPNQESRHNANSHSRRSGGGQVPSKAQGNTESQFFLEDGVFRIDRRGRVHFGLVTATTETYSSSEEEDVDSLSRGEVRVAFYPGGKEMVMTEQSIGLADRTLMPGDVVRRRLPGENVLAGQAGYVRDVNVRADVMVMGSRMVIKNVPAERLRPISEWNQYVPLCMDTWIGTIIDINECAVLKSSNGARVEITSNDFHKFKDAVSECDRTVFNPNVFFPGNIVIGRMPPPDRVKNLTPEITHPLTRKGRAVYTVESVETTSINVDWSCRAIGNATGSDDTDSDPLKEPRSLIKGEELHKVKRLSLYESYELQIHDRFYLKYSKCDLLVKYADWENEQAEKYIPIFHAQKKMQRKASKLNASASTSGNARSVPKFRRMPNKISGMRLPRPPSDQTHNACKSSKRSKEDVLTSEDEDEFEEFMQPLDQSMTAEKEVEVAEDALPPSAATTAAAGVEVQAPRITMRSAKRRQVKKKIRSVKKTIYSPFNKKETTPKDGDEIVVETLVVYSSVTVVWQDGTVESGVHSTQLYPIHHLDNHEFFPGDFVTKANDISTGATDYGVIQCVDHDARIAKVMWFNIYTNIDNPIPLFKGLEELSVYDMKDHTDYQYRPGTVVIRVSNFTGEDVNSTAGQVIDNYPNGRVRVWWAKGHITLCYPQDLFQPFEQDEQNEQDQDVYGSDGSEDSWETESENSHISSSDNDDDILTGIDRATEAMKVLEKMFRVLHPNRKAEVLYDLLDVYKNCRALDRLLNTKFFDEFNFKGIVRCKPITSKVCSDSATHERATPETPETSAAVPKESSTLQAELEPVLMDPSVQSSSSPTKRKSSTEMDEVLCKKSTDEISEEQDYQVEVVEVIEDPPLVREYRCKYNEMFANARRSIAKAIENRTKNDSGVHSRGEITSDESNNHPDSENKLDIKHPTINVMDDLEIELVASGDADVCEVFCYLIKFQMARIRKTVAVTLGKTNDNPKQEKEDVSDAEEAIEAVSQEAELANDGATECNTMAEDEAMEEPLNLNALSESLPAIDQTGPMACSSPSWSIIPDTPSVDENCFQVLPNAPAAHNFISNLITPANKAQYQRAVQREYLMLKSSLPNGVVVRAYEDRMDLMSVMMVGPKRTPYQNALFFFDFQFGRDYPKSPPVCHYISYCTDRLNPNLYEGGRVCVSLLGTWMGRDNEVWSPSSTMLQVLVSIQGLILVDEPYYNEAGYEKQRGTQLGNENSRVYNEMAIIKIAQSTVKQLTNPPLIFRNELIEHFKEFGTELYARMRAWSEYSLEAQRQNITKIKDMPVEYKASCELPEFPLLPCSRGFCIAVKRVLSQLQSELTALGANLVTDERNGIATGIGTAPRAAPEEI", "length": 1398 }, "evidence": [ { "id": "F1N3I3", "url": "https://omabrowser.org/oma/group/F1N3I3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZVX1-1", "protein_name": "Probable ubiquitin-conjugating enzyme E2 23", "gene_name": "UBC23", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEHEQDDPGTSTNVGVDSSVDDSMASLSICDSEHPNIYRQDIVKNKKTGSVGVVSEVAGDSDSDSDISDEEEDDDDDEDNDDDDEDVEEGKKASEENVVNGDGEKKADGNYKCGALEGDQIRVLWMDNTEPVQDINDVTVIDRGFLHGDYVASASEPTGQVGVVVDVNISVDLLAPDGSIHKDISTKNLKRVRDFAVGDYVVHGPWLGRIDDVLDNVTVLFDDGSMCKVLRVEPLRLKPIPKNNLEEDANFPYYPGQRVKASSSSVFKNSRWLSGLWKPNRLEGTVTKVTAGSIFVYWIASAGFGPDSSVSPPEEQNPSNLTLLSCFTHANWQVGDWCLLPSLNQSATIPLHKHVSKLRLYDSQADRQQKIGRDLEDVQDEVSGKVEPAGITAEALPKVTSDDPPQRNPSVSKEPVHEPWPLHRKKIRKLVIRKDKKVKKKEESFEQALLVVNSRTRVDVSWQDGTIECRREAITLIPIETPGDHEFVSEQYVVEKTSDDGDNTTEPRRAGVVKNVNAKDRTASVRWLNPLRRAEEPREFEKEEIVSVYELEGHPDYDYCYGDVVVRLSPIAVALPASSPGNSFEEATQQDNGYQDSESHQEAKILVDKEENEPSTDLSKLSWVGNITGLKDGDIEVTWADGTISTVGPHAVYVVGRDDDDESVAGESETSDAASWETLNDDDRGAPEIPEEDLGRSSSIEGNSDADIYAENDSGRNGALALPLAAIEFVTRLASGIFSRARKSVDSSSSDYTVENVYKQAESTNPSDETDSLDDPSPSKVNVTDNCESKGTQANAKNILSGETSTFLEDEDKPVPSEGDSCSFRRFDISQDPLDHHFLGVDGQKTKERQWFKKVDQDWKILQNNLPDGIFVRAYEDRMDLLRAVIVGAFGTPYQDGLFFFDFHLPSDYPSVPPSAYYHSGGWRLNPNLYEEGKVCLSLLNTWTGRGNEVWDPKSSSILQVLVSLQGLVLNSKPYFNEAGYDKQVGTAEGEKNSLGYNENTFLLNCKTMMYLMRKPPKDFEELIKDHFRKRGYYILKACDAYMKGYLIGSLTKDASVIDERSSANSTSVGFKLMLAKIAPKLFSALSEVGADCNEFQHLQQQ", "length": 1102 }, "evidence": [ { "id": "F1N3I3", "url": "https://omabrowser.org/oma/group/F1N3I3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of BMP signaling pathway", "id": "GO:0030513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030513", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" }, { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "F1N3I3", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 825, "end_pos": 827, "annotation": "n_glycosylation_sequon" }, { "start_pos": 937, "end_pos": 939, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A3KMV5-1", "A3KN22-1", "A6H795-1", "Q32PA5-1", "Q3MHP1-1", "A5PJC4-1", "Q0P5K3-1", "Q17QG5-1", "Q1RMW1-1", "Q1RMX2-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32P99-1", "Q1RML1-1", "A0A3Q1MLB6-1", "F1N1X8-1", "F1N3I3-1", "F1ME38-1", "A0A3Q1MAR8-1", "Q32L27-1", "A0ABI0NWC8-1" ], "evidence": [ { "id": "R-BTA-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983152" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KMV5", "gene_name": "UBA1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A3KMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV5" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A3KMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV5" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1ME38", "gene_name": "UBA6", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 952, "end_pos": 1112, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.24", "ec_name": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.24", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.24" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 825, "end_pos": 827 }, { "start_pos": 937, "end_pos": 939 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3J6-1", "uniprot_ac": "F1N3J6", "uniprot_id": "F1N3J6_BOVIN", "mass": { "chemical_mass": 56312.0, "monoisotopic_mass": 56312.0 }, "refseq": { "ac": "XP_005220098", "name": "phosphatidylinositol-glycan biosynthesis class W protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220098" }, "gene_names": [ { "name": "PIGW", "type": "recommended", "evidence": [ { "id": "F1N3J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ] }, { "name": "PIG-W", "type": "synonym", "evidence": [ { "id": "XP_005220098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220098" } ] }, { "name": "PIGW", "type": "synonym", "evidence": [ { "id": "XP_005220098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220098" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol-glycan biosynthesis class W protein", "type": "recommended", "evidence": [ { "id": "F1N3J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J6/entry#names_and_taxonomy" } ] }, { "name": "2.3.-.-", "type": "synonym", "evidence": [ { "id": "F1N3J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J6/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol-glycan biosynthesis class W protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005220098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220098" } ] } ], "function": [ { "annotation": "A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.", "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6#function" }, { "database": "UniProtKB", "id": "RU280819", "url": "https://www.uniprot.org/uniprotkb/RU280819#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGW", "url": "https://www.uniprot.org/uniprotkb/F1N3J6", "locus": { "chromosome": "19", "start_pos": 12888779, "end_pos": 12883089, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034396", "url": "https://www.ensembl.org/id/ENSBTAG00000034396" } ] } } ], "crossref": [ { "id": "ENSBTAG00000034396", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034396", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "768052", "url": "https://www.ncbi.nlm.nih.gov/gene/768052", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GLYVMQP", "url": "https://omabrowser.org/oma/group/GLYVMQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3J6", "url": "https://www.orthodb.org/?gene=F1N3J6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20661:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20661:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-162710", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005220098", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220098", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3J6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3J6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQKQMKEAFVSNQNGTSVLEITEGLCLPALCILCRGLLIILSQQLCSSLHNSRTRFLVDFAFLIVPLVTTLTIFSSFVLLEYLVAIILGAGLLYEIYCRRTCYARMPFQKICEKFLKVSLESEHIPAISCFRVVNSAFTAVAILAVDFPLFPRRYAKTELYGTGAMDYGVGGFIFGSAMVSPEVRRKYTKGSRFCYLTKSLYSLWPLVFLGVGRLVAIKSVDYQEHLTEYGVHWNFFFTLIAVKLITSLLLIICPLNRSWVVAISIAALYQLALDFTPLKSLILYGTDGSGTRVGLLNANREGIISILGYVAVHMAGVQTGLYVLKKRSHIKDWIKVACCILLTAIGLFISLYIVQVNVEVASRRMANLAFCIWIVASCLILLSSLLLGDIILSFAKFVIKEAAVPCSWKLIQSPTANKKHLESIVFDAKRKEPTLCLITAMNRNQLLFFLLSNVTTGLVNLSIDTLHSSTPWALCLLNLYMFTNCLIIYVLHLQDKTIKFW", "length": 503, "header": "tr|F1N3J6-1|F1N3J6_BOVIN Isoform 1 of Phosphatidylinositol-glycan biosynthesis class W protein OS=Bos taurus OX=9913 GN=PIGW PE=3 SV=1 CANONICAL=F1N3J6-1" }, "isoforms": [ { "isoform_ac": "F1N3J6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3J6/entry", "sequence": { "sequence": "MSQKQMKEAFVSNQNGTSVLEITEGLCLPALCILCRGLLIILSQQLCSSLHNSRTRFLVDFAFLIVPLVTTLTIFSSFVLLEYLVAIILGAGLLYEIYCRRTCYARMPFQKICEKFLKVSLESEHIPAISCFRVVNSAFTAVAILAVDFPLFPRRYAKTELYGTGAMDYGVGGFIFGSAMVSPEVRRKYTKGSRFCYLTKSLYSLWPLVFLGVGRLVAIKSVDYQEHLTEYGVHWNFFFTLIAVKLITSLLLIICPLNRSWVVAISIAALYQLALDFTPLKSLILYGTDGSGTRVGLLNANREGIISILGYVAVHMAGVQTGLYVLKKRSHIKDWIKVACCILLTAIGLFISLYIVQVNVEVASRRMANLAFCIWIVASCLILLSSLLLGDIILSFAKFVIKEAAVPCSWKLIQSPTANKKHLESIVFDAKRKEPTLCLITAMNRNQLLFFLLSNVTTGLVNLSIDTLHSSTPWALCLLNLYMFTNCLIIYVLHLQDKTIKFW", "length": 503, "header": "tr|F1N3J6-1|F1N3J6_BOVIN Isoform 1 of Phosphatidylinositol-glycan biosynthesis class W protein OS=Bos taurus OX=9913 GN=PIGW PE=3 SV=1 CANONICAL=F1N3J6-1" }, "locus": { "chromosome": "19", "start_pos": 12887154, "end_pos": 12885646, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121587.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121587.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093171.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-162710", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "resource": "Reactome", "description": "Synthesis of glycosylphosphatidylinositol (GPI)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AP94-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "PIGW", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSQKQMKEAFVSNHNGTSVLEITEGLCLPAFCILCRGLLIVLSPHLRSSSHTWRTRFFIDFAFLIVPLVITLTVFSTFVLLEYLIVIIFGAGLFYEIYCRRTCYAGMPVQKILEKFLKVSLESEYIPAVSCFRVINSAFTAVAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFIFGTAMVCPEVRGIYTKGSRLCYLRKSLCSVWPLVLLGMGRLVIIKSIGYQEHLTEYGVHWNFFFTIIVVKLITSLLLIIFPLNKSWIVALSMTVLYQLALNFTPLKSFILYGTDGSGTRVGLLNANREGIISTLGYAAIHMAGVQTGSYVLKKRPHIKDWIKVTYCVLLTAIGLFIALYILQVTVEVASRRMANLAFCIWIVASCLILLSSLLLGDIILSFAKFLIKGAAVPCSWELIQSPGINKKHSESLVSKAERKEPICCLITAMNRNQLIFFLLSNVTTGLINLSVDTLHSNTLWALFLLNLYMFSNCLIIYVLHLQNKTIKFW", "length": 503 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AB48-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "PIGW", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQKHLKEAFVSNLNGTSLLELSLGMPLAPLCLLCRGLLLVLHCQHRGKPLRSRPPALLLDFGVLVAPLLFSCTVLSPVLFLVPAILAAFCAGIFFTLYRQRQRDSRVHFRQIVKDFQNTYLDPDYVPAITVFRVYVNVLTSISILAVDFPQFPRRYAKAETYGTGVMDLGVGAFIFSNALVCPEVRQKAAVTQPKFSSLTKQLFAIWPLVVLGVGRLLSVKSIEYHEHISEYGVHWNFFFTLALVRIAASLLLAIFPKNKSWIVAVTVAVLYQLILNLTSLKTFVLHGSDGEDSRTGFLNANREGLLSLFGYLAIYMASVQVGLYLLKRRDSVKEWMGAVCLLLLAALVLFVFLHISQAHTDPVSRRMANLSYCLWVIAYCLTLFVSFVVADLMLVFTKLLVKGSAVPSCWRAVKAPDSREQRQAEAVHVCLIAAINKNQLLFFLLANVMTGIVNVMIDTIHSRAALTLCILHLYMFLNCFIMYILHAKNIVLKFW", "length": 497 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B3H6K1-1", "protein_name": "Uncharacterized protein At4g17910", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTFLLFQLLVLLRYSIGFHCKIDNNGVKSVTSKKNDDEKIVISRNWKAAISLDFIFIVFPMLLFFTVLSEWVYHGTGLLSLLVLILSVTAKRSFSGLQRGQSLSFRASVSSYRVALMLITCLCILAVDFTIFPRRYAKTETYGTSLMDLGVGSFVLANAVVSRQARDVSSGNWITGIKATAPLLLLGFIRLVTTSGVDYQVHVTEYGVHWNFFFTLAAISILTSFVNIPAKYCGLLGFAVLAGYQTWLLSGLNTYLLSDERGTDIISKNKEGVYSILGYWGMYLLGVHLGYRLFYGKHTNIRSTTSSIARVFLVSLLLWIVTILFDNYVERISRRTCNMPYVTWVLAQDLQALGIFMLSSYIPLNKLSSLEEAIDQNLLATFLLANLVTGMVNLTVDTIFASPFSSLLILTAYAFALSAIIGTIHFSGFRLKFW", "length": 434 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F1QAR3-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "pigw", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASSEGKIAFVSNLNGTTLTEVSLGSFLAPVCFLSRGLFLIVFHLGKGVLPFSWGAHLMLDFTTIIMPMVLSCTALSDILHFVIMGIAVVDFAVLYLVYKRKKNPSSLKSTIDKFIQSRAESKMVPFVTIFRVLVNVKTAISILAVDFSVFPRRYAKTETYGTGVMDFGVGAYVMANALVCPEARGKNIQGSKISHVLKQAVSVWPLILLGFVRLASVKSSGYHEHVTEYGVHWNFFFTLAIVRVVASALLALFPVNCSGFLALIICGTYQVILETTDLKSFLIHNTERSGFLLANREGVFSVVGYIAIYMAGVHVGCYLMQSRNLVKDWIRVIRNLLLTSFGLFLVLYVCQRNIEPVSRRMANLPFCIWTVAQALFFLSCISIADVVLLFAKVVSNFSLVPTSWCPNQNKKADEKTRRDMDGLCLIQAVNRNQLLYFLLANVLTGLTNVFVDTMNSRDVLAVSVLLWYMFMNSLVIFILHVNKITVKFW", "length": 490 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H9D8-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "Pigw", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQKQMKEAFVSNLNGTSVLEITQGLCFPAFCILCRGLLIIFSQHLCSFSHNWSTWFLMDFVVLIVPLVITLTILSSFILLENLMVTVCVAWLLYQIYQRRTCYAKVPAQKVFANFLKISLESEYNPAITGYRVINSIFTAIAILAVDFPLFPRRFAKTELYGTGAMDYGVGGFIFGAAMVCPEVRRKCIVGSRFNYLRKSLYSVWPLVFLGMGRLVVIKSIGYQEHLTEYGVHWNFFFTIIVVKLVTSLLLTIFPLNKSWVVAVSITVLYQLALDFTPLKGVILYGTDGSGTRVGLLNANREGIISTLGYVTIHMAGVQTGLYVLKVRTHIRDWIKVTCCILLVAVSFFISLHIVQVNIEAVSRRMANLAFCMWVVASSLMLLSCLLLSDIILSFAKFLIKGALVPCSWKLIQLPATNKKHSESLILETEKEDPSLCLITALNRNQLFFFLLSNITTGLINLTVDTLHSGASWTLVVLCTYMFTNCLVIYVLDLQGKTIKLW", "length": 503 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P47026-1", "protein_name": "GPI-anchored wall transfer protein 1", "gene_name": "GWT1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTLKQRKEDFVTGLNGGSITEINAVTSIALVTYISWNLLKNSNLMPPGISSVQYIIDFALNWVALLLSITIYASEPYLLNTLILLPCLLAFIYGKFTSSSKPSNPIYNKKKMITQRFQLEKKPYITAYRGGMLILTAIAILAVDFPIFPRRFAKVETWGTSLMDLGVGSFVFSNGIVSSRALLKNLSLKSKPSFLKNAFNALKSGGTLLFLGLLRLFFVKNLEYQEHVTEYGVHWNFFITLSLLPLVLTFIDPVTRMVPRCSIAIFISCIYEWLLLKDDRTLNFLILADRNCFFSANREGIFSFLGYCSIFLWGQNTGFYLLGNKPTLNNLYKPSTQDVVAASKKSSTWDYWTSVTPLSGLCIWSTIFLVISQLVFQYHPYSVSRRFANLPYTLWVITYNLLFLTGYCLTDKIFGNSSEYYKVAECLESINSNGLFLFLLANVSTGLVNMSMVTIDSSPLKSFLVLLAYCSFIAVISVFLYRKRIFIKL", "length": 490 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54MC0-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "pigw", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDDQYKNDHQNFVSGNDGSTFFETCFILTLMPISVLFQRVVFATFFNNDKFPLPLALRFILEFFFIIVPFISAITFTELTPFLIVGMLITCLVVPMFAQKNVTIYFKNPKETLLNLNSMRKGFLEEYRAFVMAATCICILAVDFQVFPRRLGKTETYGISLMDIGVGSVVLSGALVSRQSRSSLIEKQQKKKREEEEDDNDKINKTSSSSSSSSSALKQQQQQVLSRSSLMWHQVKAQAPLMILGFVRMILTKSINYQEHVSEYGLHWNFFFTLGFVSISLAFLKFNANISAILGVVLICVYQFLLNSFGLTDYILNHPRDNLISMNKEGICSFVGYLAIYLIGTKIGTELFKVRSSLTEWRKFATKLLISSIVFYILWILCEIYIDKTSRRMANLGYVLAILSINLFNFSINILITLITGNHNASVIAKSINRNQLFIFLLGNILTGLINFSMKTIYAPVEQSMIIITSYTFALCLLAFILDYKNINIKFW", "length": 492 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7TSN4-1", "protein_name": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW", "gene_name": "Pigw", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQKQLKEAFVSNLSGTSVLEVTQGLCFPAFCILCRGLLIIFSQHLCSFLHTWTTQFFMDFVVLIVPLVITLTVLSSFILLENLTVILCGAWLLYQIYHRRTCYAKVPVQKVFASFLKISLESEYNPAITCYRVINSVFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFIFGAAMVCPEVRRKYTEGSRFNHLRKSLYSVWPLVFLGMGRLVIIKSIGYQEHSTEYGVHWNFFFTIIVVKLITSLLLIIFPLNKSWIVAISITVLYQLALDFTPLKGIILYGTDGRGTRVGLLNANREGIISTLGYVAIYMAGVQTGFYVFKRRAQVRDWIKATCWVFSVAVGFFISLNIVQVNVEAVSRRMANLAFCLWVVASSLMLLSCLLLSGIVLSFAKFLIKGALVPCSWKLIQSATTNRQSESLIVEAEKNKPSFCLITALNRNQLFFFLLSNVATGLINLTVDTLHTGAFWTLAVLSIYMFANCLVIYVLDLQGKTIKFW", "length": 502 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z7B1-1", "protein_name": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW", "gene_name": "PIGW", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEKQMKEAFVSNLNGTTVLEITQGLCFPAFCILCRGFLIIFSQYLCSFSPTWKTRFLTDFVVLIVPMVATLTIWASFILLELLGVIIFGAGLLYQIYRRRTCYARLPFLKILEKFLNISLESEYNPAISCFRVITSAFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFVFGSAMVCLEVRRRKYMEGSKLHYFTNSLYSVWPLVFLGIGRLAIIKSIGYQEHLTEYGVHWNFFFTIIVVKLITPLLLIIFPLNKSWIIALGITVLYQLALDFTSLKRLILYGTDGSGTRVGLLNANREGIISTLGYVAIHMAGVQTGLYMHKNRSHIKDLIKVACFLLLAAISLFISLYVVQVNVEAVSRRMANLAFCIWIVASSLILLSSLLLGDIILSFAKFLIKGALVPCSWKLIQSPVTNKKHSESLVPEAERMEPSLCLITALNRKQLIFFLLSNITTGLINLMVDTLHSSTLWALFVVNLYMFSNCLIVYVLYLQDKTVQFW", "length": 504 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C398-1", "protein_name": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW", "gene_name": "Pigw", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQKQLKEAFVRNLSGTSVLEVTQGLCFPAFCILCRGLWIIFSQHVCSFSNTWSTRFLMDFVVLIVPLVITLTVLSSFILLENLTVIVWGAWLLYQIYHRRTCYAKVPVQKVFANFLKISLESEYNPAITCYRVINSVFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFIFGAAMVCPEVRRKSIEESRFNYLRKSLYSVWPLVFLGMGRLVIIKSIGYQEHSTEYGIHWNFFFTIIVVRLVTSLLLIIFPLNKSWIVAVSITVVYQLALDYTPLKRILLYGTDGSGTRVGFLNANREGIISTLGYVTIHMAGVQTGLYVLKGRAQVRDWIKATCWVFSVAVGFFISLHIVQVNIEAVSRRMANLAFCLWVVASSLMLLSCLLLSGIILSFAQFLIKGSLVPCSWKLIQSPTTHKNHSESLILEAEKNQPSLCLITALNRNQLFFFLLSNITTGLINLTMDTLHTGALWTLVVLSIYMFTNCLVIYVLDLQGKTIKFW", "length": 503 }, "evidence": [ { "id": "F1N3J6", "url": "https://omabrowser.org/oma/group/F1N3J6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ], "pmid": "" }, { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "id": "GO:0032216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032216", "evidence": [ { "database": "UniProtKB", "id": "F1N3J6", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-75967", "R-ALL-8855661" ], "output_participant_list": [ "R-ALL-8855666" ], "enzyme_list": [ "F1N3J6-1" ], "evidence": [ { "id": "R-BTA-162683", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162683" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-75967", "participant_name": "FACoA [cytosol]", "crossref": [ { "id": "77636", "database": "ChEBI", "url": "" }, { "id": "C00040", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-8855661", "participant_name": "glucosaminyl-PI [cytoplasmic side of endoplasmic reticulum membrane]", "crossref": [ { "id": "57997", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8855666", "participant_name": "glucosaminyl-acyl-PI [cytoplasmic side of endoplasmic reticulum membrane]", "crossref": [ { "id": "52572", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1N3J6", "gene_name": "PIGW", "activity": [ { "ec_number": "2.3.-.-", "activity": "", "evidence": [ { "id": "F1N3J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3J6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 258, "end_pos": 260 }, { "start_pos": 455, "end_pos": 457 }, { "start_pos": 462, "end_pos": 464 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3K7-1", "uniprot_ac": "F1N3K7", "uniprot_id": "F1N3K7_BOVIN", "mass": { "chemical_mass": 79517.0, "monoisotopic_mass": 79517.0 }, "refseq": {}, "gene_names": [ { "name": "DBF4B", "type": "recommended", "evidence": [ { "id": "F1N3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ] } ], "protein_names": [ { "name": "DBF4 zinc finger B", "type": "synonym", "evidence": [ { "id": "F1N3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3K7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DBF4B", "url": "https://www.uniprot.org/uniprotkb/F1N3K7", "locus": { "chromosome": "19", "start_pos": 44479128, "end_pos": 44448991, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005696", "url": "https://www.ensembl.org/id/ENSBTAG00000005696" } ] } } ], "crossref": [ { "id": "F1N3K7", "url": "https://alphafold.ebi.ac.uk/entry/F1N3K7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005696", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005696", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N3K7", "url": "https://www.orthodb.org/?gene=F1N3K7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15375", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15375", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15375:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15375:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3K7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3K7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDKSKLRAPDPGAQLAVSSCLGKCQKSSPDARRQPFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREAKAESSRTSHRGCPSPSEVTVDTPPVANPKGSRARPAQKAMDPVPLSRGKELLQKAIRNQGSSSGGGSGHGSSLLSNARSWGVQILHVDEMLIRVQQLSLDAPRVKKQGLKKPEGTCPAESRTRKVARLKAPFLKVEDESSFVCFRKFRPFHLQFKSFPEISFLGPKATSPFEAPMTPSSSHHTREAKDQEPSRQSAACTVPRRRKGYCECCQEAFEELHRHLQSPRHQGFALEAHLYAEVDRIIAQLSHSFADVPFQASLPGQPGSLASDCDPLCPEPPPPHWPSPLRAVSPWRRKDDHQQAPGATEHGGTVSGMKAAAEPVEAGKVPGPTASCQELKGSADSFVDPPETPGSGSSAYQDLLTSSGLAELSSGPELPHFGHKRKVQFPTGSAEKRPGASWPQASLFVPRAPSPCGTPSSSGIRTTSSKHLPLPGHEPRSLASLQPVRHPQGKTCLSLPGSPPVGWQSAGPHRPPGLGEEGPQDTSVLRVPPLALSPSRLSSSGPAASPPALSCRHRAPRRTCREPGCLSPPPSASRRADQLLPMVLDLPASSRPLTPNPSPPPTENYFYESLPTPGHAALGQTPPNLRASYTSAEGCTPSPGRPDTQGGANPESGPGRSWPSSRCIRWSQSSQPPGLWGWGLPSPAMDHAGAASCSGQEAGARLA", "length": 748, "header": "tr|F1N3K7-1|F1N3K7_BOVIN Isoform 1 of DBF4 zinc finger B OS=Bos taurus OX=9913 GN=DBF4B PE=4 SV=4 CANONICAL=F1N3K7-1" }, "isoforms": [ { "isoform_ac": "F1N3K7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3K7/entry", "sequence": { "sequence": "MDKSKLRAPDPGAQLAVSSCLGKCQKSSPDARRQPFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREAKAESSRTSHRGCPSPSEVTVDTPPVANPKGSRARPAQKAMDPVPLSRGKELLQKAIRNQGSSSGGGSGHGSSLLSNARSWGVQILHVDEMLIRVQQLSLDAPRVKKQGLKKPEGTCPAESRTRKVARLKAPFLKVEDESSFVCFRKFRPFHLQFKSFPEISFLGPKATSPFEAPMTPSSSHHTREAKDQEPSRQSAACTVPRRRKGYCECCQEAFEELHRHLQSPRHQGFALEAHLYAEVDRIIAQLSHSFADVPFQASLPGQPGSLASDCDPLCPEPPPPHWPSPLRAVSPWRRKDDHQQAPGATEHGGTVSGMKAAAEPVEAGKVPGPTASCQELKGSADSFVDPPETPGSGSSAYQDLLTSSGLAELSSGPELPHFGHKRKVQFPTGSAEKRPGASWPQASLFVPRAPSPCGTPSSSGIRTTSSKHLPLPGHEPRSLASLQPVRHPQGKTCLSLPGSPPVGWQSAGPHRPPGLGEEGPQDTSVLRVPPLALSPSRLSSSGPAASPPALSCRHRAPRRTCREPGCLSPPPSASRRADQLLPMVLDLPASSRPLTPNPSPPPTENYFYESLPTPGHAALGQTPPNLRASYTSAEGCTPSPGRPDTQGGANPESGPGRSWPSSRCIRWSQSSQPPGLWGWGLPSPAMDHAGAASCSGQEAGARLA", "length": 748, "header": "tr|F1N3K7-1|F1N3K7_BOVIN Isoform 1 of DBF4 zinc finger B OS=Bos taurus OX=9913 GN=DBF4B PE=4 SV=4 CANONICAL=F1N3K7-1" }, "locus": { "chromosome": "19", "start_pos": 44478124, "end_pos": 44449589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007484.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007484.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007484.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007484.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 414, "start_aa": "Thr", "end_pos": 414, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr414", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 499, "start_aa": "Thr", "end_pos": 499, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr499", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 657, "start_aa": "Thr", "end_pos": 657, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr657", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 681, "start_aa": "Thr", "end_pos": 681, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr681", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of cell cycle phase transition", "id": "GO:1901987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901987", "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "pmid": "" }, { "name": "positive regulation of nuclear cell cycle DNA replication", "id": "GO:0010571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010571", "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Dbf4-dependent protein kinase complex", "id": "GO:0031431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031431", "evidence": [ { "database": "UniProtKB", "id": "F1N3K7", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3K7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 748, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3K7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3K7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3K7" }, { "id": "PS51265", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51265" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DBF4-type", "eco_id": "ECO_0000259", "start_pos": 284, "end_pos": 333, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 414, 499, 657, 681 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3P6-1", "uniprot_ac": "F1N3P6", "uniprot_id": "F1N3P6_BOVIN", "mass": { "chemical_mass": 41930.0, "monoisotopic_mass": 41930.0 }, "refseq": {}, "gene_names": [ { "name": "SLC15A5", "type": "recommended", "evidence": [ { "id": "F1N3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ] } ], "protein_names": [ { "name": "Solute carrier family 15 member 5", "type": "synonym", "evidence": [ { "id": "F1N3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3P6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC15A5", "url": "https://www.uniprot.org/uniprotkb/F1N3P6", "locus": { "chromosome": "5", "start_pos": 93699192, "end_pos": 93602194, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009444", "url": "https://www.ensembl.org/id/ENSBTAG00000009444" } ] } } ], "crossref": [ { "id": "F1N3P6", "url": "https://alphafold.ebi.ac.uk/entry/F1N3P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TVNLCFI", "url": "https://omabrowser.org/oma/group/TVNLCFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11654", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00854", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00854", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3P6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLNATVVFLGISYIQYSGAWALVLLIPFMSTLTALITLYMMHYNLIYQPEKCCSPLTTFRVFVNVLKTCCLQYCHLGGGVTSWLDHAKDKNGGRCRELLVEDVKFFSNLLPLFIFQLLYKMCIMQIPSGYYLQTVNSSLNLRGSLLPVSVMNVISILPLLILAPFMEYFSTCLLPSKRDGSFLSACILAGNLCAALSVLVAGFFEIHRKHFPPVEQLLSGKAVTVSSMAWSHLVLQYVLLRVAETLVNPAFSVIHRFVPSTIRGTFMNCLTLINGFACFMGALLFESVYLISEGNWFPNTLNKGNLENFFFFLASLTLLNVLGFWSVSQRYCNLNHFNAQNTSGSNLKETLPLQEKSLKFYGSTLEFSSSIDL", "length": 374, "header": "tr|F1N3P6-1|F1N3P6_BOVIN Isoform 1 of Solute carrier family 15 member 5 OS=Bos taurus OX=9913 GN=SLC15A5 PE=3 SV=4 CANONICAL=F1N3P6-1" }, "isoforms": [ { "isoform_ac": "F1N3P6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3P6/entry", "sequence": { "sequence": "MNLNATVVFLGISYIQYSGAWALVLLIPFMSTLTALITLYMMHYNLIYQPEKCCSPLTTFRVFVNVLKTCCLQYCHLGGGVTSWLDHAKDKNGGRCRELLVEDVKFFSNLLPLFIFQLLYKMCIMQIPSGYYLQTVNSSLNLRGSLLPVSVMNVISILPLLILAPFMEYFSTCLLPSKRDGSFLSACILAGNLCAALSVLVAGFFEIHRKHFPPVEQLLSGKAVTVSSMAWSHLVLQYVLLRVAETLVNPAFSVIHRFVPSTIRGTFMNCLTLINGFACFMGALLFESVYLISEGNWFPNTLNKGNLENFFFFLASLTLLNVLGFWSVSQRYCNLNHFNAQNTSGSNLKETLPLQEKSLKFYGSTLEFSSSIDL", "length": 374, "header": "tr|F1N3P6-1|F1N3P6_BOVIN Isoform 1 of Solute carrier family 15 member 5 OS=Bos taurus OX=9913 GN=SLC15A5 PE=3 SV=4 CANONICAL=F1N3P6-1" }, "locus": { "chromosome": "5", "start_pos": 93699189, "end_pos": 93616950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043043.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043043.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040638.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040638.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YK42-1", "protein_name": "Solute carrier family 15 member 5", "gene_name": "SLC15A5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGADSGDVQEKQLTADTEKEKNLLPGRRNHAEKLTLPEKKVQEAICVLLVELCERFTFFGIVCNMILFCTVRLGYRNYQAAIVNMCFVGTSMLTPVLAGWLAECLVGRIKLVCVCMFLHFLGTALLPIVAFPFEDIYIDKRHILLHTLTKKEQKMVFYFALLTASLGIGGIRAIVCPLSAYNLENCGPKELLSFFNWFYWLINLNSAVVFVSISYIQQSVARNLGFLLPFVSVLMAMITIHMVRGKMIYKPKTDSSLLTTFGVIGSALKTCCVRYRYFSGDVSSWLDHAKEYHGGQYSETQVESTKSLARLFPFFAFQILYRTCIMQIPSGYYLQTMNSNLNFSGFVLPIAAMNVISIVPLLILVPILECINSYLFSSKGSGHPPTMYIVAGQLCAALSVMVAGFSEIHRKHFPQVEQTLSEEVLLVSSMPCFHLAPQYILLGVAEALVTPSCSLLSFWLVPERIRGISMHFLTLFNGAGCFMGAFFVQTAHTGTQGNWFPHLLHEGKLERFFFFLASLMMVNALGFWTVAHRYSNLNQEYTSEFRGSLSEEKEVFLKHDKVIEHYGSVLDHSPILSPMETT", "length": 583 }, "evidence": [ { "id": "F1N3P6", "url": "https://omabrowser.org/oma/group/F1N3P6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A6NIM6-1", "protein_name": "Solute carrier family 15 member 5", "gene_name": "SLC15A5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVTGFTITDEKVHLYHSIEKEKTVRHIGDLCSSHSVKKIQVGICLLLVELCERFTFFEVVCNMIPFCTIKLGYHNCQAAILNLCFIGTSILTPVFVRWLTDVYLGRNKLVYICLFLHFLGTALLSVVAFPLEDFYLGTYHAVNNIPKTEQHRLFYVALLTICLGIGGVRAIVCPLGAFGLQEYGSQKTMSFFNWFYWLMNLNATIVFLGISYIQHSQAWALVLLIPFMSMLMAVITLHMIYYNLIYQSEKRCSLLTGVGVLVSALKTCHPQYCHLGRDVTSQLDHAKEKNGGCYSELHVEDTTFFLTLLPLFIFQLLYRMCIMQIPSGYYLQTMNSNLNLDGFLLPIAVMNAISSLPLLILAPFLEYFSTCLFPSKRVGSFLSTCIIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSGKVLTVSSMPCFYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNGFGCFTGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLTLLNVLGFCSVSQRYCNLNHFNAQNIRGSNLEETLLLHEKSLKFYGSIQEFSSSIDLWETAL", "length": 579 }, "evidence": [ { "id": "F1N3P6", "url": "https://omabrowser.org/oma/group/F1N3P6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZKX5-1", "protein_name": "Solute carrier family 15 member 5", "gene_name": "Slc15a5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFVTGFIINDEKAPLPLHGGPERQKTVGHLGCFRVGICSLLVELCERFTFFEVVCNMIPFCTRRLGCYNHQAAILNLCFIGASVLTPVFMGWLSDSKYLGRNKLVYIAVFLHFLGTALLSVLAFPSEDFYGGTSPASNMPMKKRAGLFHVALLTLCLGTGGIRAVVCLPDACGHWEQESKKPMSFCNWASWSMNLNTAVVFLGVSSIQLLGSGAVMILLPSLSVFTASVTLYMTYCDLIYEPENHCSLPTVSRAFARVLKTRCLLYCHLGRAGSSWLARAMAKQGVCHCELQEEETENVFSALLSLFSFQLIYRMCLTQIPSGYYLQTMHSNRTLGGVPLPIALMNAISLLPLLTLGPFMDFFSNCLLPSKRDGPFLSVCIIAGNICAAFSVAVAGFLEIHRKLAQEQSPSGKLSSVSSMACVYLVPQYVLLGVSEVLVNPAVSTVTRRVVPSTFRRASMTCLTLFHGSAYFAGALLIELVYLISEGNWFPNTLNKGNLESFFFVLASLTLLNILGLWRVLPRCCNLNHFNAQRIHGNNCEETLLLSEKSLKFYGSTQETSSSIDLRETAF", "length": 571 }, "evidence": [ { "id": "F1N3P6", "url": "https://omabrowser.org/oma/group/F1N3P6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CBB2-1", "protein_name": "Solute carrier family 15 member 5", "gene_name": "Slc15a5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPITDFIINDEKTPLVLHGGPEQWKTVGPYGCFRVGICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALLSMLAFPAENFYRGAYPVFNNTSVEEQAGLFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCDLIYRPENRCSLLTIARAFVRALKTRCLPYCHFGRDGSSWLDHAMEKQGGHHSELQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPLLILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSVAMAGFLEIYRKLAREQSPSGKLFSVSSMACVCLVPQYVLLGVSEVLVNPAVSMVTHRVIPGASMAFLTLSHGSACFAGAMLIKLLYLISEGNWFPNTLDKGNLENFFFVLASLMLLNILGLWRASWRYCNLNHFNAQRIRGNRCEETLLLTEKSLKFYGSTQGASSSIDLWETAL", "length": 566 }, "evidence": [ { "id": "F1N3P6", "url": "https://omabrowser.org/oma/group/F1N3P6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SX20-1", "protein_name": "Protein NRT1/ PTR FAMILY 3.1", "gene_name": "NPF3.1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEEQSKNKISEEEKQLHGRPNRPKGGLITMPFIFANEICEKLAVVGFHANMISYLTTQLHLPLTKAANTLTNFAGTSSLTPLLGAFIADSFAGRFWTITFASIIYQIGMTLLTISAIIPTLRPPPCKGEEVCVVADTAQLSILYVALLLGALGSGGIRPCVVAFGADQFDESDPNQTTKTWNYFNWYYFCMGAAVLLAVTVLVWIQDNVGWGLGLGIPTVAMFLSVIAFVGGFQLYRHLVPAGSPFTRLIQVGVAAFRKRKLRMVSDPSLLYFNDEIDAPISLGGKLTHTKHMSFLDKAAIVTEEDNLKPGQIPNHWRLSTVHRVEELKSVIRMGPIGASGILLITAYAQQGTFSLQQAKTMNRHLTNSFQIPAGSMSVFTTVAMLTTIIFYDRVFVKVARKFTGLERGITFLHRMGIGFVISIIATLVAGFVEVKRKSVAIEHGLLDKPHTIVPISFLWLIPQYGLHGVAEAFMSIGHLEFFYDQAPESMRSTATALFWMAISIGNYVSTLLVTLVHKFSAKPDGSNWLPDNNLNRGRLEYFYWLITVLQAVNLVYYLWCAKIYTYKPVQVHHSKEDSSPVKEELQLSNRSLVDE", "length": 596 }, "evidence": [ { "id": "F1N3P6", "url": "https://omabrowser.org/oma/group/F1N3P6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ], "pmid": "" }, { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ], "pmid": "" }, { "name": "peptide transport", "id": "GO:0015833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015833", "evidence": [ { "database": "UniProtKB", "id": "F1N3P6", "url": "https://www.uniprot.org/uniprotkb/F1N3P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3P6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 374, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3P6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3P6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3Q1-1", "uniprot_ac": "F1N3Q1", "uniprot_id": "F1N3Q1_BOVIN", "mass": { "chemical_mass": 27083.0, "monoisotopic_mass": 27083.0 }, "refseq": { "ac": "NP_001193690", "name": "oligodendrocyte transcription factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193690" }, "gene_names": [ { "name": "OLIG1", "type": "recommended", "evidence": [ { "id": "F1N3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ] }, { "name": "OLIG1", "type": "synonym", "evidence": [ { "id": "NP_001193690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193690" } ] } ], "protein_names": [ { "name": "Oligodendrocyte transcription factor 1", "type": "synonym", "evidence": [ { "id": "F1N3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1/entry#names_and_taxonomy" } ] }, { "name": "oligodendrocyte transcription factor 1", "type": "synonym", "evidence": [ { "id": "NP_001193690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193690" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OLIG1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1", "locus": { "chromosome": "1", "start_pos": 2497191, "end_pos": 2501557, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037547", "url": "https://www.ensembl.org/id/ENSBTAG00000037547" } ] } } ], "crossref": [ { "id": "F1N3Q1", "url": "https://alphafold.ebi.ac.uk/entry/F1N3Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037547", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037547", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18942", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18942", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539307", "url": "https://www.ncbi.nlm.nih.gov/gene/539307", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539307", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539307", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKFPHLF", "url": "https://omabrowser.org/oma/group/CKFPHLF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3Q1", "url": "https://www.orthodb.org/?gene=F1N3Q1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19290:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19290:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Q1-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYYAVSQARVNAAPASMLRPPRPGDVPVGASLYELVGYRQPPSSSSSSSPTGAALLPKAAREKPEAPADTPGTGPGTGAHAGGGPRADAKEEQQQQLRRKINSRERKRMHDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALEEPPCGQFALPGGGPGGGAGGPGLCTCAVCKFPHLVPAGLGLAAVPAQFSK", "length": 266, "header": "tr|F1N3Q1-1|F1N3Q1_BOVIN Isoform 1 of Oligodendrocyte transcription factor 1 OS=Bos taurus OX=9913 GN=OLIG1 PE=4 SV=2 CANONICAL=F1N3Q1-1" }, "isoforms": [ { "isoform_ac": "F1N3Q1-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1/entry", "sequence": { "sequence": "MYYAVSQARVNAAPASMLRPPRPGDVPVGASLYELVGYRQPPSSSSSSSPTGAALLPKAAREKPEAPADTPGTGPGTGAHAGGGPRADAKEEQQQQLRRKINSRERKRMHDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALEEPPCGQFALPGGGPGGGAGGPGLCTCAVCKFPHLVPAGLGLAAVPAQFSK", "length": 266, "header": "tr|F1N3Q1-1|F1N3Q1_BOVIN Isoform 1 of Oligodendrocyte transcription factor 1 OS=Bos taurus OX=9913 GN=OLIG1 PE=4 SV=2 CANONICAL=F1N3Q1-1" }, "locus": { "chromosome": "1", "start_pos": 2499871, "end_pos": 2499074, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054480.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054480.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052609.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052609.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539307", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539307", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SGZ6-1", "protein_name": "Oligodendrocyte transcription factor 1", "gene_name": "OLIG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYYAVSQARVNAAPATMLRPQRPGDVQLGTSLYELVGYRQPPSSSSSSSTSSSTTGPLLPKAAREKLEAPAEPPGTGSGPGAHTGGSSRADAKEEQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGPGGGAGSPGLCTCAVCKFPHLVPAGLGLAAVQAQFSK", "length": 269 }, "evidence": [ { "id": "F1N3Q1", "url": "https://omabrowser.org/oma/group/F1N3Q1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8TAK6-1", "protein_name": "Oligodendrocyte transcription factor 1", "gene_name": "OLIG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK", "length": 271 }, "evidence": [ { "id": "F1N3Q1", "url": "https://omabrowser.org/oma/group/F1N3Q1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JKN5-1", "protein_name": "Oligodendrocyte transcription factor 1", "gene_name": "Olig1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYYAISQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSSSSSSTASLLPKPAREKAEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFSLPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK", "length": 260 }, "evidence": [ { "id": "F1N3Q1", "url": "https://omabrowser.org/oma/group/F1N3Q1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9WUQ3-1", "protein_name": "Oligodendrocyte transcription factor 1", "gene_name": "Olig1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYYAVSQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSSTSSSSTASLLPKPAREKPEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFALPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK", "length": 261 }, "evidence": [ { "id": "F1N3Q1", "url": "https://omabrowser.org/oma/group/F1N3Q1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" }, { "name": "oligodendrocyte development", "id": "GO:0014003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" }, { "name": "axon development", "id": "GO:0061564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061564", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" }, { "name": "sensory organ development", "id": "GO:0007423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007423", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "F1N3Q1", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3Q1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 266, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3Q1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3Q1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Q1" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 155, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3S3-1", "uniprot_ac": "F1N3S3", "uniprot_id": "F1N3S3_BOVIN", "mass": { "chemical_mass": 43612.0, "monoisotopic_mass": 43612.0 }, "refseq": { "ac": "XP_002688591", "name": "nuclear receptor subfamily 2 group F member 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688591" }, "gene_names": [ { "name": "NR2F6", "type": "recommended", "evidence": [ { "id": "F1N3S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ] }, { "name": "NR2F6", "type": "synonym", "evidence": [ { "id": "XP_002688591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688591" } ] } ], "protein_names": [ { "name": "Nuclear receptor subfamily 2 group F member 6", "type": "recommended", "evidence": [ { "id": "F1N3S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3S3/entry#names_and_taxonomy" } ] }, { "name": "V-erbA-related protein 2", "type": "synonym", "evidence": [ { "id": "F1N3S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3S3/entry#names_and_taxonomy" } ] }, { "name": "nuclear receptor subfamily 2 group F member 6", "type": "synonym", "evidence": [ { "id": "XP_002688591", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688591" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NR2F6", "url": "https://www.uniprot.org/uniprotkb/F1N3S3", "locus": { "chromosome": "7", "start_pos": 5871049, "end_pos": 5859919, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011136", "url": "https://www.ensembl.org/id/ENSBTAG00000011136" } ] } } ], "crossref": [ { "id": "F1N3S3", "url": "https://alphafold.ebi.ac.uk/entry/F1N3S3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011136", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011136", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06948", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06948", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06958", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06958", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100296331", "url": "https://www.ncbi.nlm.nih.gov/gene/100296331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EPYSNSR", "url": "https://omabrowser.org/oma/group/EPYSNSR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3S3", "url": "https://www.orthodb.org/?gene=F1N3S3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002688591", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688591", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3S3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3S3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMVTGGWGGPGGGGDTNGVDKAGGYPRAAEEDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGTVAASSGSPPGSALAVAGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGAAGAFGAGSGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ", "length": 412, "header": "tr|F1N3S3-1|F1N3S3_BOVIN Isoform 1 of Nuclear receptor subfamily 2 group F member 6 OS=Bos taurus OX=9913 GN=NR2F6 PE=3 SV=2 CANONICAL=F1N3S3-1" }, "isoforms": [ { "isoform_ac": "F1N3S3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3S3/entry", "sequence": { "sequence": "MAMVTGGWGGPGGGGDTNGVDKAGGYPRAAEEDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGTVAASSGSPPGSALAVAGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGAAGAFGAGSGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ", "length": 412, "header": "tr|F1N3S3-1|F1N3S3_BOVIN Isoform 1 of Nuclear receptor subfamily 2 group F member 6 OS=Bos taurus OX=9913 GN=NR2F6 PE=3 SV=2 CANONICAL=F1N3S3-1" }, "locus": { "chromosome": "7", "start_pos": 5870045, "end_pos": 5860118, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014791.8", "url": "https://www.ensembl.org/id/ENSBTAT00000014791.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014791.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014791.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296331", "resource": "KEGG Pathway" }, { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S962-1", "protein_name": "Nuclear receptor subfamily 2 group F member 6", "gene_name": "NR2F6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMVTGGWGGPGGGGGGGDTNGVDKAGGYPRAAEEDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAAGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGAAGAFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ", "length": 415 }, "evidence": [ { "id": "F1N3S3", "url": "https://omabrowser.org/oma/group/F1N3S3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1N3S3", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3S3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 412, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3S3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3S3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 165, "end_pos": 401, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3S3" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 130, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3T1-1", "uniprot_ac": "F1N3T1", "uniprot_id": "F1N3T1_BOVIN", "mass": { "chemical_mass": 55364.0, "monoisotopic_mass": 55364.0 }, "refseq": {}, "gene_names": [ { "name": "KRT39", "type": "recommended", "evidence": [ { "id": "F1N3T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ] } ], "protein_names": [ { "name": "Keratin 39", "type": "synonym", "evidence": [ { "id": "F1N3T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3T1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT39", "url": "https://www.uniprot.org/uniprotkb/F1N3T1", "locus": { "chromosome": "19", "start_pos": 41163720, "end_pos": 41170540, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020078", "url": "https://www.ensembl.org/id/ENSBTAG00000020078" } ] } } ], "crossref": [ { "id": "F1N3T1", "url": "https://alphafold.ebi.ac.uk/entry/F1N3T1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PCATKCE", "url": "https://omabrowser.org/oma/group/PCATKCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3T1", "url": "https://www.orthodb.org/?gene=F1N3T1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3T1-1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTKGCTTTMSSATPCQSCSGITNLTTILPNTSCQHGGLKANSCQPTGHDLRTLQSQDDEPTPCFSLTPLCLISNFHTCPFLDDCGWCDGSINSNEKETMKILNNRLTKYLEKVRMLERENAALECKIQEECNKELPVICPDYLSYYATIEELQQKILCTKAENSRLVSQIDNTKLTADDVRAKYEAEVSLRQLVEADANGLQQILNALTLGKADLEAQVQSLKEELLCLKNDHEQEISSLQSQLGDRLNIEVTSAPSVDLNRVLREMRCQYESIMETNRKDVEEWFNTQMEELNQQVVTSTQQQQCYQKEIIELRRTMNALEIELHAQHRMRDSQECALTETEARYAALLTQIQCLIDNLEAQLAEIRGALERQNREYEILLDVKSRLECEIATYHSLLESSDGKLPCHPCAIKHEPSACISSKARTMECTAPVHTSSLGPCGIHESRSACSILPRILVKICTITEEIKDGKVISSHKHVQPCFITRTAKA", "length": 492, "header": "tr|F1N3T1-1|F1N3T1_BOVIN Isoform 1 of Keratin 39 OS=Bos taurus OX=9913 GN=KRT39 PE=3 SV=2 CANONICAL=F1N3T1-1" }, "isoforms": [ { "isoform_ac": "F1N3T1-1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1/entry", "sequence": { "sequence": "MDTKGCTTTMSSATPCQSCSGITNLTTILPNTSCQHGGLKANSCQPTGHDLRTLQSQDDEPTPCFSLTPLCLISNFHTCPFLDDCGWCDGSINSNEKETMKILNNRLTKYLEKVRMLERENAALECKIQEECNKELPVICPDYLSYYATIEELQQKILCTKAENSRLVSQIDNTKLTADDVRAKYEAEVSLRQLVEADANGLQQILNALTLGKADLEAQVQSLKEELLCLKNDHEQEISSLQSQLGDRLNIEVTSAPSVDLNRVLREMRCQYESIMETNRKDVEEWFNTQMEELNQQVVTSTQQQQCYQKEIIELRRTMNALEIELHAQHRMRDSQECALTETEARYAALLTQIQCLIDNLEAQLAEIRGALERQNREYEILLDVKSRLECEIATYHSLLESSDGKLPCHPCAIKHEPSACISSKARTMECTAPVHTSSLGPCGIHESRSACSILPRILVKICTITEEIKDGKVISSHKHVQPCFITRTAKA", "length": 492, "header": "tr|F1N3T1-1|F1N3T1_BOVIN Isoform 1 of Keratin 39 OS=Bos taurus OX=9913 GN=KRT39 PE=3 SV=2 CANONICAL=F1N3T1-1" }, "locus": { "chromosome": "19", "start_pos": 41170341, "end_pos": 41163732, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026752.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026752.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026752.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026752.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 62, "start_aa": "Thr", "end_pos": 62, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr62", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6A163-1", "protein_name": "Keratin, type I cytoskeletal 39", "gene_name": "KRT39", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTKGCTTTNSPSTPCQNCSRITNVSTISSNNGCHPGGLTVNNCQPAGHVLRIPWDQGCQPTPRFCRKPIYLMNNFNARFSLDDCSWYGEGINSNEKETMQILNERLANYLQKVRMLERENAELESKIQEESNKELPVLCPDYLSYYTTIEELQQKILCTKAENSRLVSQIDNTKLTADDLRAKYEAEVSLRQLVESDANGLKQILNVLTLGKADLEAQVQSLKEELLCLKNNHKEEINSLQCQLGERLDIEVTAAPSADLNQVLQEMRCQYEPIMETNRKDVEQWFNTQIEELNQQVVTSSQQQQCCQKEIIELRRSVNTLEVELQAQHRMRDSQECILTETEARYTALLTQIQSLIDNLEAQLAEIRCALERQNQEYEILLDVKSRLECEITTYRSLLESSDGKRPCYPRATKCEPSPWTSCKSGAIESTAPACTSSSPCSLKEHCSACGPLSRILVKICTITKEIKDGKVISSYEHVQPCFIIRPAKV", "length": 491 }, "evidence": [ { "id": "F1N3T1", "url": "https://omabrowser.org/oma/group/F1N3T1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6IFW3-1", "protein_name": "Keratin, type I cytoskeletal 39", "gene_name": "Krt39", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTKGSTVTISSSTPPQNCSGNTNVRTNSSNKSCYHDVQSTGHALQTPQGQGCRPSPCLYRCPNYLIRTYSFHPCPDDCSRCSDGINSHEKETMQILNERLASYLEKVRMLEGENADLEDKIQEECSKTLPILCPDYLSYYTTIEQLQQKILCTKAENSRLVSQIDNTKLAADDLRAKYEAELSLRQLVEADANGLKQILDALTLSKADLEARVQSLTEELLCLKTNHEEEINSLQCQLGDRINIEVTAAPSVDLNQILQKMRCQYESIVETNRKDVEEWFNTQMEELNQQVVSSSQQQQCCQKDIIELRRTISALEVELQAQHRMRDSQECILAETEARYTALLAQIQSLIHNLEAQVAEIRSALQRQNQEYEVLLDIKSRLECEIATYRSLLESLDGRLPCNPCTTTWEPSCQARAMECLTPVYTSISLPGIHKPCRASGPPSRILVKICTITKEIKDGKVISSHEHVQPCYITRPAKV", "length": 481 }, "evidence": [ { "id": "F1N3T1", "url": "https://omabrowser.org/oma/group/F1N3T1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6IFX4-1", "protein_name": "Keratin, type I cytoskeletal 39", "gene_name": "Krt39", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTKGSTVTISSSTPPQNCSGNTNFRTNSSSNKSCCHDGQSTGCALQTPQGQGCGSSPCLYRCPHYLIRTYSFHPCLDDGSRCTEGINTHEKETMQILNERLANYLEKVRMLEGENADLEDKIQEACSKALPILCPDYLSYYTTIEELQQKILCTKAENSRLVSQIDNTKLAADDLRANYEAELSLRQLVEADANGLKQILDALTLSKADLEARVQSLTEELLCLKTNHEEEVNSLQCQLGDRINIEVTAAPSVDLNQILQEMRCRYESIMETNRKDVEEWFNTQMEELNQQVVSSSQQQQCCQKDIIELRRTISALEIELQAQHRMRESQECILTETEARYTALLAQIQSLIHNLEAQVADIRSALQRQSQEYEVLLDIKSRLECEIATYRSLLESLDGRLPCNPCATKWEPSCQARAMECFTPVYTSSSLPGIHKPCRASGPPSRILVKICTITKEIKDGKVISSYEHVQPCYITRATKV", "length": 482 }, "evidence": [ { "id": "F1N3T1", "url": "https://omabrowser.org/oma/group/F1N3T1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "pmid": "" }, { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "F1N3T1", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3T1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 492, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3T1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3T1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3T1" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 407, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 62 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 }, { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3V3-1", "uniprot_ac": "F1N3V3", "uniprot_id": "F1N3V3_BOVIN", "mass": { "chemical_mass": 24224.0, "monoisotopic_mass": 24224.0 }, "refseq": { "ac": "XP_003587100", "name": "regulator of G-protein signaling 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587100" }, "gene_names": [ { "name": "RGS2", "type": "recommended", "evidence": [ { "id": "F1N3V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ] }, { "name": "RGS2", "type": "synonym", "evidence": [ { "id": "XP_003587100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587100" } ] } ], "protein_names": [ { "name": "Regulator of G-protein signaling 2", "type": "recommended", "evidence": [ { "id": "F1N3V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3V3/entry#names_and_taxonomy" } ] }, { "name": "regulator of G-protein signaling 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003587100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587100" } ] } ], "function": [ { "annotation": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3#function" }, { "database": "UniProtKB", "id": "ARBA00045332", "url": "https://www.uniprot.org/uniprotkb/ARBA00045332#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS2", "url": "https://www.uniprot.org/uniprotkb/F1N3V3", "locus": {} } ], "crossref": [ { "id": "F1N3V3", "url": "https://alphafold.ebi.ac.uk/entry/F1N3V3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034366", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034366", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08709", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08709", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100848920", "url": "https://www.ncbi.nlm.nih.gov/gene/100848920", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848920", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848920", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GRMKRTI", "url": "https://omabrowser.org/oma/group/GRMKRTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3V3", "url": "https://www.orthodb.org/?gene=F1N3V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003587100", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587100", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3V3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSALFLAVQHECGPMDKGAGTGPKNEEKREKMKRTLLKDWKSRLSYFLQNSSSPGKPKTGKKSKQQTFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKAKKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT", "length": 211, "header": "tr|F1N3V3-1|F1N3V3_BOVIN Isoform 1 of Regulator of G-protein signaling 2 OS=Bos taurus OX=9913 GN=RGS2 PE=4 SV=2 CANONICAL=F1N3V3-1" }, "isoforms": [ { "isoform_ac": "F1N3V3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3V3/entry", "sequence": { "sequence": "MQSALFLAVQHECGPMDKGAGTGPKNEEKREKMKRTLLKDWKSRLSYFLQNSSSPGKPKTGKKSKQQTFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKAKKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT", "length": 211, "header": "tr|F1N3V3-1|F1N3V3_BOVIN Isoform 1 of Regulator of G-protein signaling 2 OS=Bos taurus OX=9913 GN=RGS2 PE=4 SV=2 CANONICAL=F1N3V3-1" }, "locus": { "chromosome": "16", "start_pos": 12428839, "end_pos": 12426232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026460.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026460.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026460.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026460.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848920", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848920", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MBN0-1", "protein_name": "Regulator of G-protein signaling 2", "gene_name": "Rgs2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT", "length": 211 }, "evidence": [ { "id": "F1N3V3", "url": "https://omabrowser.org/oma/group/F1N3V3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O08849-1", "protein_name": "Regulator of G protein signaling 2", "gene_name": "Rgs2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSAPGKPKTGKKSKQQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKSLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT", "length": 211 }, "evidence": [ { "id": "F1N3V3", "url": "https://omabrowser.org/oma/group/F1N3V3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P41220-1", "protein_name": "Regulator of G protein signaling 2", "gene_name": "RGS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT", "length": 211 }, "evidence": [ { "id": "F1N3V3", "url": "https://omabrowser.org/oma/group/F1N3V3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3S853-1", "protein_name": "Regulator of G protein signaling 2", "gene_name": "RGS2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQSAMFLTVHHDCGPMDKSAGTGPKSEEKREKMKRTLLKDWKTRLSYFLQNSSSPGKPKTGKKSKPQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCRKPPQITTEPHAT", "length": 212 }, "evidence": [ { "id": "F1N3V3", "url": "https://omabrowser.org/oma/group/F1N3V3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9JHX0-1", "protein_name": "Regulator of G protein signaling 2", "gene_name": "Rgs2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT", "length": 211 }, "evidence": [ { "id": "F1N3V3", "url": "https://omabrowser.org/oma/group/F1N3V3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "pmid": "" }, { "name": "negative regulation of G protein-coupled receptor signaling pathway", "id": "GO:0045744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045744", "evidence": [ { "database": "UniProtKB", "id": "F1N3V3", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3V3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 211, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3V3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3V3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3V3" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 83, "end_pos": 199, "start_aa": "Ala", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 }, { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3W3-1", "uniprot_ac": "F1N3W3", "uniprot_id": "F1N3W3_BOVIN", "mass": { "chemical_mass": 72129.0, "monoisotopic_mass": 72129.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100124497", "type": "recommended", "evidence": [ { "id": "F1N3W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W3" } ] } ], "protein_names": [ { "name": "Zinc finger protein 211-like", "type": "recommended", "evidence": [ { "id": "F1N3W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3W3", "url": "https://www.uniprot.org/uniprotkb/F1N3W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100124497", "url": "https://www.uniprot.org/uniprotkb/F1N3W3", "locus": {} } ], "crossref": [ { "id": "F1N3W3", "url": "https://alphafold.ebi.ac.uk/entry/F1N3W3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038635", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038635", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3W3", "url": "https://www.uniprot.org/uniprotkb/F1N3W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3W3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3W3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAALSAPHQGSVTFEDVAMYFSWEEWCLLDEAQIQLYLDVMLENFALVCMLGSWRGVQDKETPSEEIKPAGVLQFRTPRAGLSPEKTQPCAMCIPVLRDILHLAEEQGTNGEQKAYTCAACGKAFYFTANIQQHQKQHVRENPFLCNTERPSFLKTCTVHSAGNFSTYMEIGNDFMASMGVQPQATNTGKKLNNSTECEVVFHSGESHHSLGEGKIVSSHTDILVEHERVLISEAVCEVNKCEKAGTQRSNLIQHVQVHTGEKSYQCSRCEEFFSHKSQILSHQSFNCGGMLYDCSECGKSFSRRKYLISHRRIHTGEKPYECKECNKSFRRKGNLIEHQRVHTREKPYQCKQCGKFFARKSIFLAHERIHTGENPYECNKCGKALTTISSFYYHLRVHTGERPYECNECGKSFTTLSTLSNHQRVHSGERPFKCSECEKFFSRKEHLSAHMNVHTGEKPYECNKCGKSFTSRSNLCNHWRVHIGERPFKCSECGKCFTSSSSFLRHQRVHTGERPYECSECGKSFVASSGLRYHQRVHNGERPYECSECGKNFTARSTLRDHQRVHTGEKPYKCSECGKYFTSRSSLLRHQRVHTEERPYECSQCGRSFTTQTYLYDHHRVHIGKGL", "length": 630, "header": "tr|F1N3W3-1|F1N3W3_BOVIN Isoform 1 of Zinc finger protein 211-like OS=Bos taurus OX=9913 GN=LOC100124497 PE=3 SV=4 CANONICAL=F1N3W3-1" }, "isoforms": [ { "isoform_ac": "F1N3W3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3W3/entry", "sequence": { "sequence": "MAAAALSAPHQGSVTFEDVAMYFSWEEWCLLDEAQIQLYLDVMLENFALVCMLGSWRGVQDKETPSEEIKPAGVLQFRTPRAGLSPEKTQPCAMCIPVLRDILHLAEEQGTNGEQKAYTCAACGKAFYFTANIQQHQKQHVRENPFLCNTERPSFLKTCTVHSAGNFSTYMEIGNDFMASMGVQPQATNTGKKLNNSTECEVVFHSGESHHSLGEGKIVSSHTDILVEHERVLISEAVCEVNKCEKAGTQRSNLIQHVQVHTGEKSYQCSRCEEFFSHKSQILSHQSFNCGGMLYDCSECGKSFSRRKYLISHRRIHTGEKPYECKECNKSFRRKGNLIEHQRVHTREKPYQCKQCGKFFARKSIFLAHERIHTGENPYECNKCGKALTTISSFYYHLRVHTGERPYECNECGKSFTTLSTLSNHQRVHSGERPFKCSECEKFFSRKEHLSAHMNVHTGEKPYECNKCGKSFTSRSNLCNHWRVHIGERPFKCSECGKCFTSSSSFLRHQRVHTGERPYECSECGKSFVASSGLRYHQRVHNGERPYECSECGKNFTARSTLRDHQRVHTGEKPYKCSECGKYFTSRSSLLRHQRVHTEERPYECSQCGRSFTTQTYLYDHHRVHIGKGL", "length": 630, "header": "tr|F1N3W3-1|F1N3W3_BOVIN Isoform 1 of Zinc finger protein 211-like OS=Bos taurus OX=9913 GN=LOC100124497 PE=3 SV=4 CANONICAL=F1N3W3-1" }, "locus": { "chromosome": "18", "start_pos": 64989320, "end_pos": 64963591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053442.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053442.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052716.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052716.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N3W3", "url": "https://www.uniprot.org/uniprotkb/F1N3W3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1N3W3", "url": "https://www.uniprot.org/uniprotkb/F1N3W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 118, "end_pos": 145, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N3W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W3" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 85, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 555, "end_pos": 557 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3W6-1", "uniprot_ac": "F1N3W6", "uniprot_id": "F1N3W6_BOVIN", "mass": { "chemical_mass": 148780.0, "monoisotopic_mass": 148780.0 }, "refseq": { "ac": "XP_010820453", "name": "mitogen-activated protein kinase kinase kinase 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820453" }, "gene_names": [ { "name": "MAP3K15", "type": "recommended", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "name": "MAP3K15", "type": "synonym", "evidence": [ { "id": "XP_010820453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820453" } ] } ], "protein_names": [ { "name": "mitogen-activated protein kinase kinase kinase", "type": "recommended", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.25", "type": "synonym", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6/entry#names_and_taxonomy" } ] }, { "name": "mitogen-activated protein kinase kinase kinase 15", "type": "synonym", "evidence": [ { "id": "XP_010820453", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820453" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAP3K15", "url": "https://www.uniprot.org/uniprotkb/F1N3W6", "locus": { "chromosome": "X", "start_pos": 123765254, "end_pos": 123618942, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019855", "url": "https://www.ensembl.org/id/ENSBTAG00000019855" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019855", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019855", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06624", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06624", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529335", "url": "https://www.ncbi.nlm.nih.gov/gene/529335", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529335", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529335", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11584", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11584", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11584:SF363", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11584:SF363", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20302", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20302", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20309", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20309", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010820453", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820453", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LNJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3W6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3W6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESGGGATPAGAVGAAAEPPQCQLPPVGEGVAGPPGPPEPEGSAEGAGVGGEGGGAGGPRRALRAVYVRSESPQGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDTLLGPLCVPLVDRFTSLLKDIHVTSCAYYKETLLNDIRRAREKYQGDELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSAGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDVFLDSDCKDDASRDSAIEWYRKGFALQPSLYSGINLAVLLIVAGQQFETSMELRKIGVRLNSLLGRKGSLEKMNSYWDVGQFFSVSMLASDVGKAVQAAERLFRLKPPVWYLRSLVQNLLLIQRFKKPLIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINSEAEERTVSLWHVSPTEMKQIHEWNFTASSIRGISISKFDERCCFLYVHDNSDDFQIYFSTENQCSRFCSLVKEMIANGMGSTVELEGETDGDTLEYEYDHDEKGERVVLGKGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSEDGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIRFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFAGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAVMFKVGMFKIHPEIPETLSAEARACLLSCFEPDPHKRVTAAGLLQEGFFRQMHKGKKNRIAFKPAEGPRGAVLTLPPSGELPGSSSSEHGSVSPDSDAQPDPFFEKSRLPVQRLSHLLSVPDESSALEDRSAASSPEDRDPGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIAILRDFIRCPEHRVMASTISKLKVDLDFDSSSINQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVEKDTDEMEEDYPPADLPASEAQVAHGWSEPASAVAQEASPQQHLSFQLSKLRQETSRLLEHLVQKEIEYQNLLRHILEQKTQELYHLRLQFTSNENSVSPPGSQEQRTDKELVDWLQLQGADTRTIEKILEEGYTLSDILNDITKEDLRYLRLRGGLLCRLWTAVSQYRRRAQGAPATQDEA", "length": 1328, "header": "tr|F1N3W6-1|F1N3W6_BOVIN Isoform 1 of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K15 PE=3 SV=4 CANONICAL=F1N3W6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNJ3/entry", "sequence": { "sequence": "MESGGGATPAGAVGAAAEPPQCQLPPVGEGVAGPPGPPEPEGSAEGAGVGGEGGGAGGPRRALRAVYVRSESPQGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDTLLGPLCVPLVDRFTSLLKDIHVTSCAYYKETLLNDIRRAREKYQGDELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSAGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDVFLDSDCKDDASRDSAIEWYRKGFALQPSLYSGINLAVLLIVAGQQFETSMELRKIGVRLNSLLGRKGSLEKMNSYWDVGQFFSVSMLASDVGKAVQAAERLFRLKPPVWYLRSLVQNLLLIQRFKKPLIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINSEAEERTVSLWHVSPTEMKQIHEWNFTASSIRGIRFCSLVKEMIANGMGSTVELEGETDGDTLEYEYDHDEKGERVVLGKGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSEDGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIRFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFAGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAVMFKVGMFKIHPEIPETLSAEARACLLSCFEPDPHKRVTAAGLLQEGFFRQMHKGKKNRIAFKPAEGPRGAVLTLPPSGELPGSSSSEHGSVSPDSDAQPDPFFEKSRLPVQRLSHLLSVPDESSALEDRSAASSPEDRDPGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIAILRDFIRCPEHRVMASTISKLKVDLDFDSSSINQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVEKDTDEMEEDYPPADLPASEAQVAHGWSEPASAVAQEASPQQHLSFQLSKLRQETSRLLEHLVQKEIEYQNLLRHILEQKTQELYHLRLQFTSNENSVSPPGSQEQRTDKELVDWLQLQGADTRTIEKILEEGYTLSDILNDITKEDLRYLRLRGGLLCRLWTAVSQYRRRAQGAPATQDEA", "length": 1296, "header": "tr|A0A3Q1LNJ3-1|A0A3Q1LNJ3_BOVIN Computationally mapped isoform of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K15 PE=3 SV=2 CANONICAL=F1N3W6-1" }, "locus": { "chromosome": "X", "start_pos": 123764250, "end_pos": 123619141, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076618.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076618.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061571.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061571.2" } ] } }, { "isoform_ac": "F1N3W6-1", "url": "https://www.uniprot.org/uniprotkb/F1N3W6/entry", "sequence": { "sequence": "MESGGGATPAGAVGAAAEPPQCQLPPVGEGVAGPPGPPEPEGSAEGAGVGGEGGGAGGPRRALRAVYVRSESPQGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDTLLGPLCVPLVDRFTSLLKDIHVTSCAYYKETLLNDIRRAREKYQGDELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSAGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDVFLDSDCKDDASRDSAIEWYRKGFALQPSLYSGINLAVLLIVAGQQFETSMELRKIGVRLNSLLGRKGSLEKMNSYWDVGQFFSVSMLASDVGKAVQAAERLFRLKPPVWYLRSLVQNLLLIQRFKKPLIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINSEAEERTVSLWHVSPTEMKQIHEWNFTASSIRGISISKFDERCCFLYVHDNSDDFQIYFSTENQCSRFCSLVKEMIANGMGSTVELEGETDGDTLEYEYDHDEKGERVVLGKGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSEDGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIRFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFAGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAVMFKVGMFKIHPEIPETLSAEARACLLSCFEPDPHKRVTAAGLLQEGFFRQMHKGKKNRIAFKPAEGPRGAVLTLPPSGELPGSSSSEHGSVSPDSDAQPDPFFEKSRLPVQRLSHLLSVPDESSALEDRSAASSPEDRDPGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIAILRDFIRCPEHRVMASTISKLKVDLDFDSSSINQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVEKDTDEMEEDYPPADLPASEAQVAHGWSEPASAVAQEASPQQHLSFQLSKLRQETSRLLEHLVQKEIEYQNLLRHILEQKTQELYHLRLQFTSNENSVSPPGSQEQRTDKELVDWLQLQGADTRTIEKILEEGYTLSDILNDITKEDLRYLRLRGGLLCRLWTAVSQYRRRAQGAPATQDEA", "length": 1328, "header": "tr|F1N3W6-1|F1N3W6_BOVIN Isoform 1 of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K15 PE=3 SV=4 CANONICAL=F1N3W6-1" }, "locus": { "chromosome": "X", "start_pos": 123764250, "end_pos": 123619141, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026456.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026456.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026456.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026456.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 8, "start_aa": "Thr", "end_pos": 8, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529335", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529335", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ], "pmid": "" }, { "name": "MAP kinase kinase kinase activity", "id": "GO:0004709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709", "evidence": [ { "database": "UniProtKB", "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "JNK cascade", "id": "GO:0007254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007254", "evidence": [ { "database": "UniProtKB", "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ], "pmid": "" }, { "name": "p38MAPK cascade", "id": "GO:0038066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038066", "evidence": [ { "database": "UniProtKB", "id": "F1N3W6", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 650, "end_pos": 906, "start_aa": "Lys", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.25", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25" }, { "id": "2.7.11.25", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 8 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 571, "end_pos": 573 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3W9-1", "uniprot_ac": "F1N3W9", "uniprot_id": "F1N3W9_BOVIN", "mass": { "chemical_mass": 55879.0, "monoisotopic_mass": 55879.0 }, "refseq": {}, "gene_names": [ { "name": "P4HTM", "type": "recommended", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ] } ], "protein_names": [ { "name": "Transmembrane prolyl 4-hydroxylase", "type": "recommended", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9/entry#names_and_taxonomy" } ] }, { "name": "1.14.11.29", "type": "synonym", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9/entry#names_and_taxonomy" } ] }, { "name": "Hypoxia-inducible factor prolyl hydroxylase 4", "type": "synonym", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9#function" }, { "database": "UniProtKB", "id": "ARBA00056324", "url": "https://www.uniprot.org/uniprotkb/ARBA00056324#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P4HTM", "url": "https://www.uniprot.org/uniprotkb/F1N3W9", "locus": { "chromosome": "22", "start_pos": 50983772, "end_pos": 50997485, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005490", "url": "https://www.ensembl.org/id/ENSBTAG00000005490" } ] } } ], "crossref": [ { "id": "F1N3W9", "url": "https://alphafold.ebi.ac.uk/entry/F1N3W9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005490", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005490", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006620", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006620", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MTQAQPC", "url": "https://omabrowser.org/oma/group/MTQAQPC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3W9", "url": "https://www.orthodb.org/?gene=F1N3W9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10869:SF246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10869:SF246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "48400", "url": "https://www.rhea-db.org/rhea/48400", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3W9-1", "url": "https://www.uniprot.org/uniprotkb/F1N3W9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAGPRPEAPSPQWPPRHHDSAEAAARLSDCEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQRRAQGPGPAPTLAPLTRLEGIKVGHERKIQLVADRDHFIRTLSLKPLLFEIPGFLSDEECRLVIHLAQMKGLQRSQILPTEEYEEAMGTMQISLLDLFQLLDQNHDGRLQLREVLAQNRLGNGRWMTPETIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHRAESSQLVRNSHHTWLYQGEGAHHVMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPRQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAGEGGADSQPEWALDRAYRDTRVEL", "length": 494, "header": "tr|F1N3W9-1|F1N3W9_BOVIN Isoform 1 of Transmembrane prolyl 4-hydroxylase OS=Bos taurus OX=9913 GN=P4HTM PE=4 SV=3 CANONICAL=F1N3W9-1" }, "isoforms": [ { "isoform_ac": "F1N3W9-1", "url": "https://www.uniprot.org/uniprotkb/F1N3W9/entry", "sequence": { "sequence": "MAAAAGPRPEAPSPQWPPRHHDSAEAAARLSDCEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQRRAQGPGPAPTLAPLTRLEGIKVGHERKIQLVADRDHFIRTLSLKPLLFEIPGFLSDEECRLVIHLAQMKGLQRSQILPTEEYEEAMGTMQISLLDLFQLLDQNHDGRLQLREVLAQNRLGNGRWMTPETIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHRAESSQLVRNSHHTWLYQGEGAHHVMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPRQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAGEGGADSQPEWALDRAYRDTRVEL", "length": 494, "header": "tr|F1N3W9-1|F1N3W9_BOVIN Isoform 1 of Transmembrane prolyl 4-hydroxylase OS=Bos taurus OX=9913 GN=P4HTM PE=4 SV=3 CANONICAL=F1N3W9-1" }, "locus": { "chromosome": "22", "start_pos": 50997473, "end_pos": 50983991, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007217.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007217.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007217.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007217.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZJG3-1", "protein_name": "Transmembrane prolyl 4-hydroxylase", "gene_name": "P4htm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAVATVQRPVAETIEEASNLQWPLPPEHRPSGAATRPGDGEEAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESTDPGPQRREQSPQPVPTLGPLTRLEGIKVGYERKVQVVAGRDHFIRTLSLKPLLFEIPGFLSDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSAMRVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGRWMTPENIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETVCSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDNVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGADSQPEWALDRAYSDARAEL", "length": 503 }, "evidence": [ { "id": "F1N3W9", "url": "https://omabrowser.org/oma/group/F1N3W9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SKI9-1", "protein_name": "Transmembrane prolyl 4-hydroxylase", "gene_name": "P4HTM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAAAAAGPRREDSSPQWTPPPREPVGAAAGLGDCEDAPVRPLGKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQRRTQSPGPAPTLAPLTRLEGIKVGHERKVQLVADRDHFIRTLSLKPLLFEVPGFLSDEECRLIIHLAQMKGLQRSQILPTEEYEEAMGTMQISQLDLFQLLDQNHDGHLQLREVLAQTRLGNGRWMTPENIQEMYSAIKADPDGDGVLSLQEFSDMDLRDFHKYMRSHKAESSELVRNSYHTWLYQGEGAHHVMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDIDLRDTRRHCDKGNLRVKPRQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGADSQPEWALDRAYRNARVEL", "length": 497 }, "evidence": [ { "id": "F1N3W9", "url": "https://omabrowser.org/oma/group/F1N3W9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BG58-1", "protein_name": "Transmembrane prolyl 4-hydroxylase", "gene_name": "P4htm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVATVQRPEAETVEEASNLQWPLPPEHRPSGAATRPGDSEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESTDPGPQRREQSPQPVPTLGPLTRLEGIKVGYERKVQVVAGRDHFIRTLSLKPLLFEIPGFLSDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSAMQVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGRWMTPENIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESNELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIVEFSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGMDSQPEWALDRAYSDARVEL", "length": 503 }, "evidence": [ { "id": "F1N3W9", "url": "https://omabrowser.org/oma/group/F1N3W9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NXG6-1", "protein_name": "Transmembrane prolyl 4-hydroxylase", "gene_name": "P4HTM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL", "length": 502 }, "evidence": [ { "id": "F1N3W9", "url": "https://omabrowser.org/oma/group/F1N3W9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X1WG80-1", "protein_name": "Transmembrane prolyl 4-hydroxylase", "gene_name": "p4htmb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLSGKMMEPQDDIEEDDSPSASAPPSSSPSPSSSPPPRALPRQRTSLQKSSVCSRSYFMVVMVFFHVYIINVIALLLYVHYNNGSNAISANRDFTSSDSSSHKVTGASDAQATADSGFPRNMFLPRIEGIRVGHVQKVSLVSGKVHEMKTLSLKPLLFEIPDFLSEEECAVVVRLAQLKGLMESQVMVPEGQEELDQQLNLSPEEIFNFLDLNQDGQLQPHEILTHSRVRDGIWLTSENLKEIYDGLKADLDGNGLLSLEEFGRLRSDAFQRFLLQRGVERSQLVRNSRHTWLYQGQGAHQVLQDLRKRVTLLTRLPSSLVELSEPLQVVRYEQGGHYHAHHDSGPVYPETACTHTRLAANTTSPFQTSCRYITVLFYLNNVQEGGETTFPVADNRTYEEASLIQNDVDLLDTRKHCDKGNLRVKPVKGTAVFWYNYLSDGRGWVGEQDEYSLHGGCVVTQGTKWVANNWINVDPDYQRQARYQLLVSQQESQEQEEPNSDQHIEAHQDL", "length": 510 }, "evidence": [ { "id": "F1N3W9", "url": "https://omabrowser.org/oma/group/F1N3W9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" }, { "name": "L-ascorbic acid binding", "id": "GO:0031418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031418", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" }, { "name": "procollagen-proline 4-dioxygenase activity", "id": "GO:0004656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004656", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" }, { "name": "hypoxia-inducible factor-proline dioxygenase activity", "id": "GO:0160082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160082", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of erythrocyte differentiation", "id": "GO:0045646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045646", "evidence": [ { "database": "UniProtKB", "id": "F1N3W9", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48400", "name": "", "equation": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0P3Q1-1", "A0AAA9SDY7-1", "A0A3Q1M2B6-1", "F1N3W9-1" ], "evidence": [ { "id": "48400", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48400" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M2B6", "gene_name": "EGLN1", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0A3Q1M2B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B6" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0A3Q1M2B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B6" } ] } ] }, { "uniprot_ac": "A0AAA9SDY7", "gene_name": "EGLN3", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ] } ] }, { "uniprot_ac": "A0ABI0P3Q1", "gene_name": "EGLN2", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0ABI0P3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3Q1" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0ABI0P3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3Q1" } ] } ] }, { "uniprot_ac": "F1N3W9", "gene_name": "P4HTM", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3W9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 494, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3W9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3W9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" }, { "id": "PS51471", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51471" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fe2OG dioxygenase", "eco_id": "ECO_0000259", "start_pos": 302, "end_pos": 452, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.11.29", "ec_name": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "1.14.11.29", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29" }, { "id": "1.14.11.29", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.11.29" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 340, "end_pos": 342 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 374, "end_pos": 376 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3Z2-1", "uniprot_ac": "F1N3Z2", "uniprot_id": "F1N3Z2_BOVIN", "mass": { "chemical_mass": 37638.0, "monoisotopic_mass": 37638.0 }, "refseq": {}, "gene_names": [ { "name": "GBX1", "type": "recommended", "evidence": [ { "id": "F1N3Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ] } ], "protein_names": [ { "name": "Homeobox protein GBX-1", "type": "recommended", "evidence": [ { "id": "F1N3Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2/entry#names_and_taxonomy" } ] }, { "name": "Gastrulation and brain-specific homeobox protein 1", "type": "synonym", "evidence": [ { "id": "F1N3Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GBX1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2", "locus": { "chromosome": "4", "start_pos": 113720310, "end_pos": 113742581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011120", "url": "https://www.ensembl.org/id/ENSBTAG00000011120" } ] } } ], "crossref": [ { "id": "F1N3Z2", "url": "https://alphafold.ebi.ac.uk/entry/F1N3Z2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011120", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011120", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24334:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24334:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Z2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRAGGGGASGGSSGGGGGGGGGGGPGTAFSIDSLIGPPPPRSGHLLYTGYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAVPSMVALTTALPSFAEPPDAFYGPPELAAAAAAATAARNHPEPGGRRPEGGLDTDEPLPAREKVAEPPAPPPAHFSETFPSLPAEGKVYSSDEEKLEAPAGDPAGSEQEEEGSGADSEDDAFLDSSAGGPGALLGPKPKLKGGLGTAVEEGAPSTGVPAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQMEQGARP", "length": 365, "header": "tr|F1N3Z2-1|F1N3Z2_BOVIN Isoform 1 of Homeobox protein GBX-1 OS=Bos taurus OX=9913 GN=GBX1 PE=4 SV=4 CANONICAL=F1N3Z2-1" }, "isoforms": [ { "isoform_ac": "F1N3Z2-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2/entry", "sequence": { "sequence": "MQRAGGGGASGGSSGGGGGGGGGGGPGTAFSIDSLIGPPPPRSGHLLYTGYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLASFAGRLTNTFCAGLGQAVPSMVALTTALPSFAEPPDAFYGPPELAAAAAAATAARNHPEPGGRRPEGGLDTDEPLPAREKVAEPPAPPPAHFSETFPSLPAEGKVYSSDEEKLEAPAGDPAGSEQEEEGSGADSEDDAFLDSSAGGPGALLGPKPKLKGGLGTAVEEGAPSTGVPAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQMEQGARP", "length": 365, "header": "tr|F1N3Z2-1|F1N3Z2_BOVIN Isoform 1 of Homeobox protein GBX-1 OS=Bos taurus OX=9913 GN=GBX1 PE=4 SV=4 CANONICAL=F1N3Z2-1" }, "locus": { "chromosome": "4", "start_pos": 113742428, "end_pos": 113721314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014768.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014768.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014768.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014768.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "pmid": "" }, { "name": "regulation of nervous system development", "id": "GO:0051960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051960", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3Z2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 365, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3Z2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3Z2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N3Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z2" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 261, "end_pos": 321, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 325, "end_pos": 327 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3Z7-1", "uniprot_ac": "F1N3Z7", "uniprot_id": "F1N3Z7_BOVIN", "mass": { "chemical_mass": 61280.0, "monoisotopic_mass": 61280.0 }, "refseq": { "ac": "XP_005226022", "name": "cytochrome P450 4V2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226022" }, "gene_names": [ { "name": "CYP4V2", "type": "recommended", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ] }, { "name": "CYP4V2", "type": "synonym", "evidence": [ { "id": "XP_005226022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226022" } ] } ], "protein_names": [ { "name": "Cytochrome P450 4V2", "type": "recommended", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7/entry#names_and_taxonomy" } ] }, { "name": "1.14.14.79", "type": "synonym", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7/entry#names_and_taxonomy" } ] }, { "name": "1.14.14.80", "type": "synonym", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7/entry#names_and_taxonomy" } ] }, { "name": "Docosahexaenoic acid omega-hydroxylase CYP4V2", "type": "synonym", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7/entry#names_and_taxonomy" } ] }, { "name": "Long-chain fatty acid omega-monooxygenase", "type": "synonym", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7/entry#names_and_taxonomy" } ] }, { "name": "cytochrome P450 4V2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005226022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226022" } ] } ], "function": [ { "annotation": "A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7#function" }, { "database": "UniProtKB", "id": "ARBA00057964", "url": "https://www.uniprot.org/uniprotkb/ARBA00057964#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYP4V2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7", "locus": { "chromosome": "27", "start_pos": 16266690, "end_pos": 16250292, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021263", "url": "https://www.ensembl.org/id/ENSBTAG00000021263" } ] } } ], "crossref": [ { "id": "F1N3Z7", "url": "https://alphafold.ebi.ac.uk/entry/F1N3Z7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021263", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021263", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510156", "url": "https://www.ncbi.nlm.nih.gov/gene/510156", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QQMHLFS", "url": "https://omabrowser.org/oma/group/QQMHLFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3Z7", "url": "https://www.orthodb.org/?gene=F1N3Z7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291:SF193", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291:SF193", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-211976", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211976", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2453902", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2453902", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005226022", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226022", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38947", "url": "https://www.rhea-db.org/rhea/38947", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39791", "url": "https://www.rhea-db.org/rhea/39791", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40155", "url": "https://www.rhea-db.org/rhea/40155", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40199", "url": "https://www.rhea-db.org/rhea/40199", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40203", "url": "https://www.rhea-db.org/rhea/40203", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Z7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLAPWLLSVGPKLLLWSGLCAVSLAGATLTLNLLKMVASYARKWRQMRPVPTIGDPYPLVGHALMMKPDARDFFQQIIDFTEECRHLPLLKLWLGPVPLVALYNAETVEVILSSSKHIEKSYMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDVMNEQANILVTKLEKHVNQEAFNCFFYVTLCTLDIICETAMGKNIGAQRNDDSEYVRAVYRMSDSIHQRMKMPWLWLDLIFYMFKNGREHRRSLKIVHDFTNNVITERANEMKRHEEGTSNDKEKDFPPRKTKCRAFLDLLLNVTDDQGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGWYPEVQQKVDTELEEVFGKSDRPVTLEDLKKLKYLDCVIKESLRLFPSVPFFARNLTEDCEVAGHKIVQGCQVIIVPYALHRDPKYFPDPEEFKPERFFPENLKGRHTYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKREELGLAGELILRPSNGIWIKLKRRNTDES", "length": 527, "header": "tr|F1N3Z7-1|F1N3Z7_BOVIN Isoform 1 of Cytochrome P450 4V2 OS=Bos taurus OX=9913 GN=CYP4V2 PE=3 SV=1 CANONICAL=F1N3Z7-1" }, "isoforms": [ { "isoform_ac": "F1N3Z7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7/entry", "sequence": { "sequence": "MLAPWLLSVGPKLLLWSGLCAVSLAGATLTLNLLKMVASYARKWRQMRPVPTIGDPYPLVGHALMMKPDARDFFQQIIDFTEECRHLPLLKLWLGPVPLVALYNAETVEVILSSSKHIEKSYMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDVMNEQANILVTKLEKHVNQEAFNCFFYVTLCTLDIICETAMGKNIGAQRNDDSEYVRAVYRMSDSIHQRMKMPWLWLDLIFYMFKNGREHRRSLKIVHDFTNNVITERANEMKRHEEGTSNDKEKDFPPRKTKCRAFLDLLLNVTDDQGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGWYPEVQQKVDTELEEVFGKSDRPVTLEDLKKLKYLDCVIKESLRLFPSVPFFARNLTEDCEVAGHKIVQGCQVIIVPYALHRDPKYFPDPEEFKPERFFPENLKGRHTYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKREELGLAGELILRPSNGIWIKLKRRNTDES", "length": 527, "header": "tr|F1N3Z7-1|F1N3Z7_BOVIN Isoform 1 of Cytochrome P450 4V2 OS=Bos taurus OX=9913 GN=CYP4V2 PE=3 SV=1 CANONICAL=F1N3Z7-1" }, "locus": { "chromosome": "27", "start_pos": 16264371, "end_pos": 16250613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002785.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002785.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002785.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002785.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-211976", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211976", "resource": "Reactome", "description": "Endogenous sterols" }, { "id": "R-BTA-2453902", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2453902", "resource": "Reactome", "description": "The canonical retinoid cycle in rods (twilight vision)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YT74-1", "protein_name": "Cytochrome P450 4V2", "gene_name": "CYP4V2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAMEITLGSMEGTQLLPWVAGAITLLLTVVTVHFLPSLLNYWWWWWVMKPIPGIRPCYPFVGNALLLERNGEGFFKQLQQYADEFRKMPMFKLWLGPLPVTVLFHPDSVEVILSSSKHIKKSFLYTFLHPWLGTGLLTSTGDKWRSRRKMITPTFHFAILNDFLEVMNEQGGILLEKLEKHVDKEPFNIFTDITLCALDIICETAMGKNLGAQDNKDSEYVRAVYRMSDLIQQRQKSPWLWHDLMYLLFKEGREHEQNLKILHGFTDTVIAEKVAELENTKLTKHDTDVNTEEESGSKKREAFLDMLLNATDDEGKKLSYKDIREEVDTFMFEGHDTTAAAMNWVLYLLGHHPEAQKKVHQELDEVFGNTERPVTVDDLKKLRYLECVVKEALRLFPSVPMFARSLQEDCYISGYKLPKGTNVLVLTYVLHRDPEIFPEPDEFRPERFFPENSKGRHPYAYVPFSAGPRNCIGQRFAQMEEKTLLALILRRFWVDCSQKPEELGLSGELILRPNNGIWVQLKRRPKTVTE", "length": 530 }, "evidence": [ { "id": "F1N3Z7", "url": "https://omabrowser.org/oma/group/F1N3Z7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2RRT9-1", "protein_name": "Cytochrome P450 4V2", "gene_name": "Cyp4v2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLWLWLGLSGQKLLLWGAASAVSVAGATVLLNILQMLVSYARKWQQMRPIPSVARAYPLVGHALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQEAFNCFFPITLCALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTFTNNVIAERVNARKAEQDCIGAGRGPLPSKTKRKAFLDLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKREELGLAGDLILRPNNGIWIKLKRRHEDDP", "length": 525 }, "evidence": [ { "id": "F1N3Z7", "url": "https://omabrowser.org/oma/group/F1N3Z7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZWL3-1", "protein_name": "Cytochrome P450 4V2", "gene_name": "CYP4V2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER", "length": 525 }, "evidence": [ { "id": "F1N3Z7", "url": "https://omabrowser.org/oma/group/F1N3Z7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FRK4-1", "protein_name": "Cytochrome P450, family 721, subfamily A, polypeptide 1", "gene_name": "CYP721A1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVFFILVLVFFFLVFRFIYSNIWVPWRIQSHFKKQSVTGPSYRIFSGNSGEVSRLTAEAKSKPIPSGRNPHEFVHRVAPHYHEWSRVYGKTFLYWFGSKPVVATSDPRLIREALTTGGSFDRIGHNPLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVTSTMMLMEKWEDMRNGGEEIELEVHKEMHNLSAEMLSRTAFGNSVEEGKGIFELQERMMRLFYLVRWSVYIPGFRFFPSKTNREIWRIEKQIRVSILKLIENNKTAVEKSGTLLQAFMSPYTNQNGQEEKLGIEEVTDECKTFYFAAKETTANLMTFVLVLLAMNQEWQNIAREEVICVLGQTGLPTLDILQDLKTLSMIINETLRLYPPAMTLNRDTLKRAKLGDLDIPAGTQLYLSVVAMHHDKETWGDDAEEFNPRRFEDPKKQSALLVPFGLGPRTCVGQNLAVNEAKTVLATILKYYSFRLSPSYAHAPVLFVTLQPQNGAHLLFTRISS", "length": 505 }, "evidence": [ { "id": "F1N3Z7", "url": "https://omabrowser.org/oma/group/F1N3Z7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ], "pmid": "" }, { "name": "long-chain fatty acid omega-hydroxylase activity", "id": "GO:0102033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102033", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid omega-oxidation", "id": "GO:0010430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010430", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z7", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38947", "name": "", "equation": "dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 12-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3Z7-1" ], "evidence": [ { "id": "38947", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38947" } ] }, { "id": "39791", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3Z7-1" ], "evidence": [ { "id": "39791", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39791" } ] }, { "id": "40155", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3Z7-1" ], "evidence": [ { "id": "40155", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40155" } ] }, { "id": "40199", "name": "", "equation": "hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3Z7-1" ], "evidence": [ { "id": "40199", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40199" } ] }, { "id": "40203", "name": "", "equation": "tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 14-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N3Z7-1" ], "evidence": [ { "id": "40203", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40203" } ] }, { "id": "R-BTA-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-6786220" ], "output_participant_list": [ "R-ALL-6786225" ], "enzyme_list": [ "F1N3Z7-1" ], "evidence": [ { "id": "R-BTA-6786239", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6786239" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6786220", "participant_name": "DHA [endoplasmic reticulum membrane]", "crossref": [ { "id": "77016", "database": "ChEBI", "url": "" }, { "id": "ZINC000004474564", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-6786225", "participant_name": "HDoHE [endoplasmic reticulum membrane]", "crossref": [ { "id": "77015", "database": "ChEBI", "url": "" }, { "id": "ZINC000096095509", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1N3Z7", "gene_name": "CYP4V2", "activity": [ { "ec_number": "1.14.14.80", "activity": "hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ] }, { "ec_number": "1.14.14.79", "activity": "", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ] }, { "ec_number": "1.14.14.80", "activity": "", "evidence": [ { "id": "F1N3Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3Z7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 527, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3Z7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3Z7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.14.80", "ec_name": "hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).", "evidence": [ { "id": "1.14.14.80", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80" }, { "id": "1.14.14.80", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.14.80" } ] }, { "ec_number": "1.14.14.79", "ec_name": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).", "evidence": [ { "id": "1.14.14.79", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79" }, { "id": "1.14.14.79", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.14.79" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 403, "end_pos": 405 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N3Z8-1", "uniprot_ac": "F1N3Z8", "uniprot_id": "F1N3Z8_BOVIN", "mass": { "chemical_mass": 49654.0, "monoisotopic_mass": 49654.0 }, "refseq": {}, "gene_names": [ { "name": "PPP4R2", "type": "recommended", "evidence": [ { "id": "F1N3Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ] } ], "protein_names": [ { "name": "Protein phosphatase 4 regulatory subunit 2", "type": "synonym", "evidence": [ { "id": "F1N3Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP4R2", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8", "locus": { "chromosome": "22", "start_pos": 28655148, "end_pos": 28705401, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002147", "url": "https://www.ensembl.org/id/ENSBTAG00000002147" } ] } } ], "crossref": [ { "id": "F1N3Z8", "url": "https://alphafold.ebi.ac.uk/entry/F1N3Z8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002147", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002147", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR015267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504900", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504900", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMEDTPV", "url": "https://omabrowser.org/oma/group/PMEDTPV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3Z8", "url": "https://www.orthodb.org/?gene=F1N3Z8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16487", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16487", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16487:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16487:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09184", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09184", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5693607", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Z8-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VCAREGEGVGGVGGGLPVPGRPAEGGGGCEGLREAMDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVYPSSEKNNSNSLNRMNGVMFPGNSPSYTERSNINGPGTPRPLNRPKIPLSVPMTTNGLPESTDSKESKQNEDKNHSDSSTSESEVSSVSPIKNKHPDEDTVEAEGHEVKRLRFDKESEVREMASQTSSSEISSVMVEETESPSSSQNKDKESSCTRQHCTEEEEEEDEEEEEESFMTSREMIAERKNQEKESDDALTVNEETSEENNQMEESDLTQVERGLHSEGSENTGPVSSGSDCHETEELVGSNSSKTGEILSESSMENDEATEVTDEPMEQD", "length": 447, "header": "tr|F1N3Z8-1|F1N3Z8_BOVIN Isoform 1 of Protein phosphatase 4 regulatory subunit 2 OS=Bos taurus OX=9913 GN=PPP4R2 PE=3 SV=4 CANONICAL=F1N3Z8-1" }, "isoforms": [ { "isoform_ac": "F1N3Z8-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8/entry", "sequence": { "sequence": "VCAREGEGVGGVGGGLPVPGRPAEGGGGCEGLREAMDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVYPSSEKNNSNSLNRMNGVMFPGNSPSYTERSNINGPGTPRPLNRPKIPLSVPMTTNGLPESTDSKESKQNEDKNHSDSSTSESEVSSVSPIKNKHPDEDTVEAEGHEVKRLRFDKESEVREMASQTSSSEISSVMVEETESPSSSQNKDKESSCTRQHCTEEEEEEDEEEEEESFMTSREMIAERKNQEKESDDALTVNEETSEENNQMEESDLTQVERGLHSEGSENTGPVSSGSDCHETEELVGSNSSKTGEILSESSMENDEATEVTDEPMEQD", "length": 447, "header": "tr|F1N3Z8-1|F1N3Z8_BOVIN Isoform 1 of Protein phosphatase 4 regulatory subunit 2 OS=Bos taurus OX=9913 GN=PPP4R2 PE=3 SV=4 CANONICAL=F1N3Z8-1" }, "locus": { "chromosome": "22", "start_pos": 28705424, "end_pos": 28656152, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002784.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002784.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002784.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002784.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504900", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504900", "resource": "KEGG Pathway" }, { "id": "R-BTA-5693607", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "resource": "Reactome", "description": "Processing of DNA double-strand break ends" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AZP4-1", "protein_name": "Protein phosphatase 4 regulatory subunit 2", "gene_name": "PPP4R2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVYPSSEKNNSNSLNRMNGVMFPGNSPSYTDRSNINGPGTPRPLNRPKVSLSVPMTTNGLPESTDSKESNLKQNEDKNHSDSSTSESEGSSVSPIKNKHPDEDAVEAEGHEVKRLRFDKESEVREMASQTSSSEISSDMVEETEAPSSSQNKDKESSCTRQHCTEEDEEEDEEEEEESFMTSREMIPERKNQEKESDDALTVNEETSEENNQMEESDLTQVERDLHSEGSENTGPVSSGSDCHETEELVGSNSSKTGEILSESTMENDEATEVTDEPMEQD", "length": 414 }, "evidence": [ { "id": "F1N3Z8", "url": "https://omabrowser.org/oma/group/F1N3Z8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A8H5-1", "protein_name": "Protein phosphatase 4, regulatory subunit 2", "gene_name": "Ppp4r2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVCPSSEKNNSNSLNRMNGVMFPGNSPNYTDRSNINGPGTPRPLNRPKLSLSAPLTTNGLPESTDSRDSDLQLSEEKGHSDSSASDSEVSSPSSGKNKHPDEDTVESEEREVKRLKFDDEGDVRETASQAVSSEVSSVRAEETETASSPPEKDRENRTRQHCTEEEEEEEEEEEEESFMTPREMVPERKNQEKESDDALTVNEETSEESHQTEGSGASPSQTDSASERSDSAGASRGGSDCRETQESGGPPARKTGECVSGSAMENDEATEVTDEPVEQE", "length": 413 }, "evidence": [ { "id": "F1N3Z8", "url": "https://omabrowser.org/oma/group/F1N3Z8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0VGB7-1", "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "gene_name": "Ppp4r2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVCPSSEKNNSNSLNRMNGVMFPGNSPNYTDRSNINGPGTPRPLNRPKLSLSAPLTTNGLPESTDSKDSELQLSEEKGHSDSSASESEVSLLSPVKNKHPDEDAVESEEHEVKRLKFDKEGDVRETASQTVSGEVSSVRAEETETAAPPPDKDRESRTRQHCTEEEEEEEEEEEEEEEESFMTPREMVPERKNQEKESDDALTVNEETSEESHQMEGSGVSPAQTDSTSERSDSAGASRSGSDCLETQESGGPPSSKTGESVSVPSSMESEEATEVTDDPMEQD", "length": 417 }, "evidence": [ { "id": "F1N3Z8", "url": "https://omabrowser.org/oma/group/F1N3Z8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NY27-1", "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "gene_name": "PPP4R2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVYPSSEKNNSNSLNRMNGVMFPGNSPSYTERSNINGPGTPRPLNRPKVSLSAPMTTNGLPESTDSKEANLQQNEEKNHSDSSTSESEVSSVSPLKNKHPDEDAVEAEGHEVKRLRFDKEGEVRETASQTTSSEISSVMVGETEASSSSQDKDKDSRCTRQHCTEEDEEEDEEEEEESFMTSREMIPERKNQEKESDDALTVNEETSEENNQMEESDVSQAEKDLLHSEGSENEGPVSSSSSDCRETEELVGSNSSKTGEILSESSMENDDEATEVTDEPMEQD", "length": 417 }, "evidence": [ { "id": "F1N3Z8", "url": "https://omabrowser.org/oma/group/F1N3Z8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W2U4-1", "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "gene_name": "PPP4R2r", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVTMENSDEIMQILERFTDLKQKEIPKELEEYLQYVAKTGDTIFKWSSLKYLFREKLLSVIKHFNEDSPRLEEIPNYPNVDPFNYETMKSSLLERLDLFNAAPFTVQRLCELLIDPRKQYSRIDKFMRALEKNILVVSTIDPGRKRTESENGDSLDSVVNGDLSMEVNIDIEMENNNGNADEGSSPGAGSAGCAQKASCPRSDDNDQPKAKKAKLEIDGEERSEASDETDTEVATRVKNEKDEKNDNDETDSPHEAAEIEEPDEEVDEADQETKTTKQPAYGSQKEGEQEESFPSSADDEAEDPMVSKSIEAEKELVAQEKKREEDKKVAIEPKEEIVKKEEVVESDKPDGKVAQLGDKAVVKKSTPPADGENQEPVKVKAENEKEEKKHAPIKTEKQDDIDSTETDDAPSAEKPAEEKIASSESKPKTKSEDDPEAETKKSQPEKTETEAAEKSVSDEKQAAEPNAESENRNDLTTSKATEAAQESVEKSPVEDASSPAVEDLAAATTPQSPLGAADSAAETPPAETGDDSQASPLVAAVTPPVLALNDQPMEDTPAEEEARVSPSATVEEVVMAESANAGAMATEEAAKDDPAAMEIDDTSQEVMMQ", "length": 609 }, "evidence": [ { "id": "F1N3Z8", "url": "https://omabrowser.org/oma/group/F1N3Z8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" }, { "name": "protein phosphatase 4 complex", "id": "GO:0030289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030289", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" }, { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of double-strand break repair via homologous recombination", "id": "GO:0010569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010569", "evidence": [ { "database": "UniProtKB", "id": "F1N3Z8", "url": "https://www.uniprot.org/uniprotkb/F1N3Z8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N3Z8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 447, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N3Z8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N3Z8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 244, "end_pos": 246 }, { "start_pos": 418, "end_pos": 420 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N406-1", "uniprot_ac": "F1N406", "uniprot_id": "F1N406_BOVIN", "mass": { "chemical_mass": 217798.0, "monoisotopic_mass": 217798.0 }, "refseq": { "ac": "NP_001179386", "name": "echinoderm microtubule-associated protein-like 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179386" }, "gene_names": [ { "name": "EML6", "type": "recommended", "evidence": [ { "id": "F1N406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N406" } ] }, { "name": "EML6", "type": "synonym", "evidence": [ { "id": "NP_001179386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179386" } ] } ], "protein_names": [ { "name": "EMAP like 6", "type": "synonym", "evidence": [ { "id": "F1N406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N406/entry#names_and_taxonomy" } ] }, { "name": "echinoderm microtubule associated protein like 6", "type": "synonym", "evidence": [ { "id": "NP_001179386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179386" } ] }, { "name": "echinoderm microtubule-associated protein-like 6", "type": "synonym", "evidence": [ { "id": "NP_001179386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179386" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N406", "url": "https://www.uniprot.org/uniprotkb/F1N406" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EML6", "url": "https://www.uniprot.org/uniprotkb/F1N406", "locus": { "chromosome": "11", "start_pos": 37719997, "end_pos": 37397967, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011101", "url": "https://www.ensembl.org/id/ENSBTAG00000011101" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011101", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011101", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516921", "url": "https://www.ncbi.nlm.nih.gov/gene/516921", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516921", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516921", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ACAKDDI", "url": "https://omabrowser.org/oma/group/ACAKDDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJS2", "url": "https://www.orthodb.org/?gene=A0A3Q1LJS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N406", "url": "https://www.orthodb.org/?gene=F1N406", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03451", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03451", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23409", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23409", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179386", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJS2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJS2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N406", "url": "https://www.uniprot.org/uniprotkb/F1N406", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N406-1", "url": "https://www.uniprot.org/uniprotkb/F1N406-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADRTAPSCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSILKDVHTHGVACLTFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECNKSLSFITHIDWSLDSKYLQTNDGAGERLFYKMPSGKSLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTDVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKKGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGLLETAPQDGGTDSYSEESDSDLSDVPELDSDIEQETQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDRLVTVGIKHIRFWQQAGGGFTSKRGIFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRAALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEMDKSGPVTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAKEQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPVHSDVTDVNAASLTKDCSLLATGDDFGFIKLFSYPVKGQHARFKKYVGHSAHVTNVRWLNNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDAEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQMKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPCIHVWDAMTKHTVSMLRCFHSKGVNYVNFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSMEAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLVRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDIFISASNDGTARIWDLADKKLLNKVSLGHAAQCAAYSPDGEMVAIGMKNGEFVVLLVNSLKVWGKKRDRKSAIQDIRISPDSRFLAVGSSEHTVDFYDLTQGTSLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSILGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSHDDKYVVSTGGDDCSVFVWRCL", "length": 1958, "header": "tr|F1N406-1|F1N406_BOVIN Isoform 1 of EMAP like 6 OS=Bos taurus OX=9913 GN=EML6 PE=3 SV=2 CANONICAL=F1N406-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJS2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJS2/entry", "sequence": { "sequence": "MWTLALSLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSILKDVHTHGVACLTFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECNKSLSFITHIDWSLDSKYLQTNDGAGERLFYKMPSGKSLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTDVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKKGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGLLETAPQDGGTDSYSEESDSDLSDVPELDSDIEQETQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDRLVTVGIKHIRFWQQAGGGFTSKRGIFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRAALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEMDKSGPVTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAKEQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPVHSDVTDVNAASLTKDCSLLATGDDFGFIKLFSYPVKGQHARFKKYVGHSAHVTNVRWLNNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDAEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQMKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPCIHVWDAMTKHTVSMLRCFHSKGVNYVNFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSMEAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLVRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDIFISASNDGTARIWDLADKKLLNKVSLGHAAQCAAYSPDGEMVAIGMKNGEFVVLLVNSLKVWGKKRDRKSAIQDIRISPDSRFLAVGSSEHTVDFYDLTQGTSLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSILGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSHDDKYVVSTGGDDCSVFVWRCL", "length": 1899, "header": "tr|A0A3Q1LJS2-1|A0A3Q1LJS2_BOVIN Computationally mapped isoform of EMAP like 6 OS=Bos taurus OX=9913 GN=EML6 PE=3 SV=2 CANONICAL=F1N406-1" }, "locus": { "chromosome": "11", "start_pos": 37719949, "end_pos": 37398291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067304.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067304.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056812.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056812.2" } ] } }, { "isoform_ac": "F1N406-1", "url": "https://www.uniprot.org/uniprotkb/F1N406/entry", "sequence": { "sequence": "MADRTAPSCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSILKDVHTHGVACLTFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECNKSLSFITHIDWSLDSKYLQTNDGAGERLFYKMPSGKSLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTDVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKKGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGLLETAPQDGGTDSYSEESDSDLSDVPELDSDIEQETQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDRLVTVGIKHIRFWQQAGGGFTSKRGIFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRAALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEMDKSGPVTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAKEQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPVHSDVTDVNAASLTKDCSLLATGDDFGFIKLFSYPVKGQHARFKKYVGHSAHVTNVRWLNNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDAEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQMKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPCIHVWDAMTKHTVSMLRCFHSKGVNYVNFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSMEAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLVRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDIFISASNDGTARIWDLADKKLLNKVSLGHAAQCAAYSPDGEMVAIGMKNGEFVVLLVNSLKVWGKKRDRKSAIQDIRISPDSRFLAVGSSEHTVDFYDLTQGTSLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSILGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSHDDKYVVSTGGDDCSVFVWRCL", "length": 1958, "header": "tr|F1N406-1|F1N406_BOVIN Isoform 1 of EMAP like 6 OS=Bos taurus OX=9913 GN=EML6 PE=3 SV=2 CANONICAL=F1N406-1" }, "locus": { "chromosome": "11", "start_pos": 37719949, "end_pos": 37436960, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014742.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014742.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014742.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014742.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516921", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516921", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ALD1-1", "protein_name": "EMAP like 6", "gene_name": "Eml6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTASKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLIATGQVGKEPYICIWDSYTVQTVSILKDVHTHGVACLAFDSDGQHLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRMVSCGVKHIKFWTLCGNSLTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLTLVRTIQGAHSAGIFSLYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVSFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECNKSLSFITHIDWSLDSKYLQTNDGAGERLFYKMPSGKPLTSKEEIKGIPWASWTCVRGPEVSGIWPKYAEVIDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTSVRWSHDFQWVLSTGGADHAVFQWRFIPEAVSNGVSETTPQGGADSCSEESDSDVSDVPELDSDIEQETQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHTQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAVHVWDTQTLKCLSLLKGHHQRGVCALDFSADGKCLVSVGLDDCHSVVFWDWKKGEKIATTRGHKDKIFVVKCNPHHADKLVTVGIKHIKFWQQAGGGFTSKRGSFGSAGKLETMMCVSYGRMEDLVFSGAATGDIYIWKDVLLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRAALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMLSFHHRKEMISDIRFSRDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAKEQLFFEAPRGRRHTIRPSETEKIEWDTWTCVLGHTCEGIWPAHSDVTDVNAASLTKDGSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDAEEDGGYDSDVAREKAIDYTTKIYAVSIRQMEGTKPHQQLKEVSMEERPPVSRAAPQPEKLQKNSITKKKKVIEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAATGVVQNLTTGGQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSVHIWDAVTKHTLSMLRCSHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGTKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSMEAARMQTMLSVAFGANNLTFTGAINGDVYVWKEHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKSAASNILIDGHMEGEIWGLATHPSKDMFISASNDGTARIWDLADKKLLNKVNLGHAARCAAYSPDGEMVAIGMKNGEFIILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTSLNRIGYCKDIPSFVIQMDFSADSKYIQVSTGAYKRQVHEVPLGKQVTEAMVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHDGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL", "length": 1957 }, "evidence": [ { "id": "F1N406", "url": "https://omabrowser.org/oma/group/F1N406/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SQM0-1", "protein_name": "Echinoderm microtubule-associated protein-like 6", "gene_name": "Eml6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLIATGQVGKEPYICIWNSYNVHTVSILKDVHTHGVACLAFDSDGQHLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRMVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLTLVRTIQGAHSAGIFSLYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVSFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECNKSLSFITHIDWSLDSKYLQTNDGAGERLFYKMPSGKPLTSKEEIKGIPWASWTCVRGPEVSGIWPKYTEVIDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKKGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEAVSNGVLETTPQEGGADSYSEESDSDFSDVPELDSDIEQETQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHAQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAVHVWDTQTLKCLSLLKGHHQRGVCALDFSADGKCLVSVGLDDFHSVVFWDWKKGEKIATTRGHKDKIFVVKCNPQHADKLVTVGIKHIKFWQQAGGGFTSKRGSFGSAGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDVLLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRTALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSSQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMLSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAKEQLFFEAPRGRKHTIRPSEAEKIEWDTWTCVLGPTCEGIWPAHSDVTDVNAANLTKDGSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDAEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQLKEVSMEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHTKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGTKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSMEAAKMQTMLSVAFGANNLTFTGAINGDVYVWKEHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKSAASNILIDGHMEGEIWGLATHPSKDMFISASNDGTARIWDLADKKLLNKVNLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNTLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEQTVDFYDLTQGTSLNRIGYCKDIPSFVIQMDFSADSKYIQVSTGAYKRQVHEVPLGKQVTEAMVVEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLLKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSSDDKYVVSTGGDDCSVFVWRCL", "length": 1958 }, "evidence": [ { "id": "F1N406", "url": "https://omabrowser.org/oma/group/F1N406/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZMW3-1", "protein_name": "Echinoderm microtubule-associated protein-like 6", "gene_name": "EML6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL", "length": 1958 }, "evidence": [ { "id": "F1N406", "url": "https://omabrowser.org/oma/group/F1N406/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1N406", "url": "https://www.uniprot.org/uniprotkb/F1N406" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1N406", "url": "https://www.uniprot.org/uniprotkb/F1N406" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1249, "end_pos": 1251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1352, "end_pos": 1354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1401, "end_pos": 1403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1469, "end_pos": 1471, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1567, "end_pos": 1569, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N406" }, { "id": "PF23409", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23409" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EML-like first beta-propeller", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 307, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N406" }, { "id": "PF23414", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23414" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EML-like second beta-propeller", "eco_id": "ECO_0000259", "start_pos": 328, "end_pos": 592, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1249, "end_pos": 1251 }, { "start_pos": 1352, "end_pos": 1354 }, { "start_pos": 1401, "end_pos": 1403 }, { "start_pos": 1469, "end_pos": 1471 }, { "start_pos": 1567, "end_pos": 1569 }, { "start_pos": 448, "end_pos": 450 }, { "start_pos": 529, "end_pos": 531 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N416-1", "uniprot_ac": "F1N416", "uniprot_id": "F1N416_BOVIN", "mass": { "chemical_mass": 89136.0, "monoisotopic_mass": 89136.0 }, "refseq": { "ac": "NP_001192705", "name": "cadherin-22 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192705" }, "gene_names": [ { "name": "CDH22", "type": "recommended", "evidence": [ { "id": "F1N416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N416" } ] }, { "name": "CDH22", "type": "synonym", "evidence": [ { "id": "NP_001192705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192705" } ] } ], "protein_names": [ { "name": "Cadherin-22", "type": "recommended", "evidence": [ { "id": "F1N416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N416/entry#names_and_taxonomy" } ] }, { "name": "Pituitary and brain cadherin", "type": "synonym", "evidence": [ { "id": "F1N416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N416/entry#names_and_taxonomy" } ] }, { "name": "cadherin 22, type 2", "type": "synonym", "evidence": [ { "id": "NP_001192705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192705" } ] }, { "name": "cadherin-22 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192705" } ] }, { "name": "cadherin-like 22", "type": "synonym", "evidence": [ { "id": "NP_001192705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192705" } ] } ], "function": [ { "annotation": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.", "evidence": [ { "database": "UniProtKB", "id": "F1N416", "url": "https://www.uniprot.org/uniprotkb/F1N416#function" }, { "database": "UniProtKB", "id": "ARBA00057645", "url": "https://www.uniprot.org/uniprotkb/ARBA00057645#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N416", "url": "https://www.uniprot.org/uniprotkb/F1N416" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDH22", "url": "https://www.uniprot.org/uniprotkb/F1N416", "locus": { "chromosome": "13", "start_pos": 74896597, "end_pos": 74980313, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005672", "url": "https://www.ensembl.org/id/ENSBTAG00000005672" } ] } } ], "crossref": [ { "id": "F1N416", "url": "https://alphafold.ebi.ac.uk/entry/F1N416", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005672", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005672", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540147", "url": "https://www.ncbi.nlm.nih.gov/gene/540147", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540147", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540147", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N416", "url": "https://www.orthodb.org/?gene=F1N416", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027:SF311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027:SF311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192705", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N416", "url": "https://www.uniprot.org/uniprotkb/F1N416", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N416-1", "url": "https://www.uniprot.org/uniprotkb/F1N416-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPRPEGRGLRAGAALSPALLLLLLLLLLPPPPPPLLGALWAAGTPAPSVQDGAPGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLREESGSGGHVFKVITDSDTQEAIIVVQKRLDFESQPVHTVVLEALNKFVDPRFADLGTFRDQAIVRVAVIDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRDSDLDQVFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQSGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHMGFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSGAIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGGGGGDGGGGGGEGSAGSAGSPPQARLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDPSVPPYDAFQTYAFEGADSPAASLSSLHSGGSSGSEQDFAYLSGWGPRFRPLAALYAGHRPDDEAPAS", "length": 829, "header": "tr|F1N416-1|F1N416_BOVIN Isoform 1 of Cadherin-22 OS=Bos taurus OX=9913 GN=CDH22 PE=4 SV=2 CANONICAL=F1N416-1" }, "isoforms": [ { "isoform_ac": "F1N416-1", "url": "https://www.uniprot.org/uniprotkb/F1N416/entry", "sequence": { "sequence": "MRPRPEGRGLRAGAALSPALLLLLLLLLLPPPPPPLLGALWAAGTPAPSVQDGAPGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLREESGSGGHVFKVITDSDTQEAIIVVQKRLDFESQPVHTVVLEALNKFVDPRFADLGTFRDQAIVRVAVIDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRDSDLDQVFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQSGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHMGFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSGAIQSCNTTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGGGGGDGGGGGGEGSAGSAGSPPQARLPSERHSLPQGPPSPEPDFSVFRDFISRKVALADGDPSVPPYDAFQTYAFEGADSPAASLSSLHSGGSSGSEQDFAYLSGWGPRFRPLAALYAGHRPDDEAPAS", "length": 829, "header": "tr|F1N416-1|F1N416_BOVIN Isoform 1 of Cadherin-22 OS=Bos taurus OX=9913 GN=CDH22 PE=4 SV=2 CANONICAL=F1N416-1" }, "locus": { "chromosome": "13", "start_pos": 74980313, "end_pos": 74897336, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007452.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007452.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007452.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007452.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540147", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540147", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N416", "url": "https://www.uniprot.org/uniprotkb/F1N416" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N416", "url": "https://www.uniprot.org/uniprotkb/F1N416" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "F1N416", "url": "https://www.uniprot.org/uniprotkb/F1N416" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N416-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 829, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N416-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N416" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N416" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 168, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 612, "end_pos": 614 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N420-1", "uniprot_ac": "F1N420", "uniprot_id": "F1N420_BOVIN", "mass": { "chemical_mass": 19110.0, "monoisotopic_mass": 19110.0 }, "refseq": { "ac": "NP_001192489", "name": "nucleoplasmin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192489" }, "gene_names": [ { "name": "NPM3", "type": "recommended", "evidence": [ { "id": "F1N420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ] }, { "name": "NPM3", "type": "synonym", "evidence": [ { "id": "NP_001192489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192489" } ] } ], "protein_names": [ { "name": "Nucleoplasmin-3", "type": "recommended", "evidence": [ { "id": "F1N420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N420/entry#names_and_taxonomy" } ] }, { "name": "nucleoplasmin-3", "type": "synonym", "evidence": [ { "id": "NP_001192489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192489" } ] } ], "function": [ { "annotation": "Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM.", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420#function" }, { "database": "UniProtKB", "id": "ARBA00055184", "url": "https://www.uniprot.org/uniprotkb/ARBA00055184#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPM3", "url": "https://www.uniprot.org/uniprotkb/F1N420", "locus": { "chromosome": "26", "start_pos": 22514804, "end_pos": 22517004, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016335", "url": "https://www.ensembl.org/id/ENSBTAG00000016335" } ] } } ], "crossref": [ { "id": "F1N420", "url": "https://alphafold.ebi.ac.uk/entry/F1N420", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016335", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016335", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504950", "url": "https://www.ncbi.nlm.nih.gov/gene/504950", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504950", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504950", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QIVCINN", "url": "https://omabrowser.org/oma/group/QIVCINN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N420", "url": "https://www.orthodb.org/?gene=F1N420", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22747", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22747", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22747:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22747:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192489", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N420-1", "url": "https://www.uniprot.org/uniprotkb/F1N420-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGAAAALTFLDQESRVRAGGVGSLQVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTISNDLSEEESEEDGSEEEEAELCPVLPAKKLGRRL", "length": 176, "header": "tr|F1N420-1|F1N420_BOVIN Isoform 1 of Nucleoplasmin-3 OS=Bos taurus OX=9913 GN=NPM3 PE=3 SV=1 CANONICAL=F1N420-1" }, "isoforms": [ { "isoform_ac": "F1N420-1", "url": "https://www.uniprot.org/uniprotkb/F1N420/entry", "sequence": { "sequence": "MAAGAAAALTFLDQESRVRAGGVGSLQVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTISNDLSEEESEEDGSEEEEAELCPVLPAKKLGRRL", "length": 176, "header": "tr|F1N420-1|F1N420_BOVIN Isoform 1 of Nucleoplasmin-3 OS=Bos taurus OX=9913 GN=NPM3 PE=3 SV=1 CANONICAL=F1N420-1" }, "locus": { "chromosome": "26", "start_pos": 22516997, "end_pos": 22515247, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021730.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021730.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021730.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021730.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504950", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504950", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZYK9-1", "protein_name": "Nucleoplasmin-3", "gene_name": "Npm3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGAAAALAFLNQESRARARGLGGLRVPAPVTMDSFFFGCELSSHTRSFTFKVEEEDDTEHVLALNMLCLTEGAKDECNVVEVVARDHDNQEIAVPVANLRLSCQPMLSVDDFQLQPPVTFRLKSGSGPVRITGRHQIVCINNDLSEESPDESEDEIKLCGILPAKKHRGRP", "length": 173 }, "evidence": [ { "id": "F1N420", "url": "https://omabrowser.org/oma/group/F1N420/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S8T7-1", "protein_name": "Nucleoplasmin-3", "gene_name": "NPM3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATGAAAALGFLNQESRCRAGGAGSLRVPTPVTMDSFFFGCELSGHSRSFTFKVEEEDDADHVLALTMLCLTEGAKDECNVVEVVARNRDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEGSEEEEAELCPIRPAKKQGGRL", "length": 176 }, "evidence": [ { "id": "F1N420", "url": "https://omabrowser.org/oma/group/F1N420/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75607-1", "protein_name": "Nucleoplasmin-3", "gene_name": "NPM3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP", "length": 178 }, "evidence": [ { "id": "F1N420", "url": "https://omabrowser.org/oma/group/F1N420/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CPP0-1", "protein_name": "Nucleoplasmin-3", "gene_name": "Npm3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGAAAALAFLNQESRARAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDTEHVLALNMLCLTEGATDECNVVEVVARDHDNQEIAVPVANLRLSCQPMLSVDDFQLQPPVTFRLKSGSGPVRITGRHQIVCINNDLSEEESDDESEEDEIKLCGILPAKKHRGRP", "length": 175 }, "evidence": [ { "id": "F1N420", "url": "https://omabrowser.org/oma/group/F1N420/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1N420", "url": "https://www.uniprot.org/uniprotkb/F1N420" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N420-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 176, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N420-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N420" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N420" }, { "id": "PF03066", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03066" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleoplasmin core", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 139, "start_aa": "Phe", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N422-1", "uniprot_ac": "F1N422", "uniprot_id": "F1N422_BOVIN", "mass": { "chemical_mass": 51315.0, "monoisotopic_mass": 51315.0 }, "refseq": { "ac": "XP_005203914", "name": "ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203914" }, "gene_names": [ { "name": "MINDY1", "type": "recommended", "evidence": [ { "id": "F1N422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ] }, { "name": "FAM63A", "type": "synonym", "evidence": [ { "id": "XP_005203914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203914" } ] }, { "name": "MINDY1", "type": "synonym", "evidence": [ { "id": "XP_005203914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203914" } ] } ], "protein_names": [ { "name": "Ubiquitin carboxyl-terminal hydrolase", "type": "recommended", "evidence": [ { "id": "F1N422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N422/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "F1N422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N422/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005203914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203914" } ] } ], "function": [ { "annotation": "Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422#function" }, { "database": "UniProtKB", "id": "ARBA00037741", "url": "https://www.uniprot.org/uniprotkb/ARBA00037741#function" }, { "database": "UniProtKB", "id": "RU367139", "url": "https://www.uniprot.org/uniprotkb/RU367139#function" }, { "database": "UniProtKB", "id": "A0ABI0NJ89", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ89#function" }, { "database": "UniProtKB", "id": "A0ABI0NWI8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWI8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MINDY1", "url": "https://www.uniprot.org/uniprotkb/F1N422", "locus": { "chromosome": "3", "start_pos": 19775894, "end_pos": 19766625, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015329", "url": "https://www.ensembl.org/id/ENSBTAG00000015329" } ] } } ], "crossref": [ { "id": "F1N422", "url": "https://alphafold.ebi.ac.uk/entry/F1N422", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015329", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015329", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505719", "url": "https://www.ncbi.nlm.nih.gov/gene/505719", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HTRFSNE", "url": "https://omabrowser.org/oma/group/HTRFSNE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N422", "url": "https://www.orthodb.org/?gene=F1N422", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18063", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18063", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18063:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18063:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203914", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203914", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NJ89", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJ89-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWI8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWI8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N422-1", "url": "https://www.uniprot.org/uniprotkb/F1N422-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHYQPEHPAPGETRTAEAVSPENHKVLSEPKEHPQDKDAKEADGAAGEQEPVDQASLPAQGQDNFESPPPDASSSQPGPARETRPETETAGACSRLQELPQSPRARQPELDFYCVKWIPWKGEQTPIITQSANGPCPLIAIANILFLQWKVKLPPQKEVITSDELMAHLGDCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKGHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSPGKGPGTGGGSGSPEKQRQVDQDYLIALSLQQQQPPPQGTSGLSDLELAQQLQQEEYQQHQAAQAAPARAPSPQGRGAASGRPAAERRQRPKQESDCVLL", "length": 469, "header": "tr|F1N422-1|F1N422_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=MINDY1 PE=3 SV=1 CANONICAL=F1N422-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NJ89-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ89/entry", "sequence": { "sequence": "MEHYQPEHPAPGETRTAEAVSPENHKVLSEPKEHPQDKDAKEADGAAGEQEPVDQASLPAQGQDNFESPPPDASSSQPGPARETRPETETAGACSRLQELPQSPRARQPELDFYCVKWIPWKGEQTPIITQSANGPCPLIAIANILFLQWKVKLPPQKEVITSDELMAHLGDCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKGHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSPGKGPGTGGGSGSPEKQRQVDQDYLIALSLQQQQPPPQGTSGLSDLELAQQLQQEEYQQHQAAQPLRAPSPQGRGAASGRPAAERRQRPKQESDCVLL", "length": 467, "header": "tr|A0ABI0NJ89-1|A0ABI0NJ89_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=MINDY1 PE=3 SV=1 CANONICAL=F1N422-1" }, "locus": { "chromosome": "3", "start_pos": 19775431, "end_pos": 19769435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154925.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154925.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104462.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104462.1" } ] } }, { "isoform_ac": "A0ABI0NWI8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWI8/entry", "sequence": { "sequence": "MEHYQPEHPAPGETRTAEAVSPENHKVLSEPKEHPQDKDAKEADGAAGEQEPVDQASLPAQGQDNFESPPPDASSSQPGPARETRPETETAGACSRLQELPQSPRARQPELDFYCVKWIPWKGEQTPIITQSANGPCPLIAIANILFLQWKVKLPPQKEVITSDELMAHLGDCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKGHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSPGKGPGTGGGSGSPEKQRQVDQQQQPPPQGTSGLSDLELAQQLQQEEYQQHQAAQAAPARAPSPQGRGAASGRPAAERRQRPKQESDCVLL", "length": 460, "header": "tr|A0ABI0NWI8-1|A0ABI0NWI8_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=MINDY1 PE=3 SV=1 CANONICAL=F1N422-1" }, "locus": { "chromosome": "3", "start_pos": 19775431, "end_pos": 19769435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106051.1" } ] } }, { "isoform_ac": "F1N422-1", "url": "https://www.uniprot.org/uniprotkb/F1N422/entry", "sequence": { "sequence": "MEHYQPEHPAPGETRTAEAVSPENHKVLSEPKEHPQDKDAKEADGAAGEQEPVDQASLPAQGQDNFESPPPDASSSQPGPARETRPETETAGACSRLQELPQSPRARQPELDFYCVKWIPWKGEQTPIITQSANGPCPLIAIANILFLQWKVKLPPQKEVITSDELMAHLGDCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKGHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSPGKGPGTGGGSGSPEKQRQVDQDYLIALSLQQQQPPPQGTSGLSDLELAQQLQQEEYQQHQAAQAAPARAPSPQGRGAASGRPAAERRQRPKQESDCVLL", "length": 469, "header": "tr|F1N422-1|F1N422_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=MINDY1 PE=3 SV=1 CANONICAL=F1N422-1" }, "locus": { "chromosome": "3", "start_pos": 19775431, "end_pos": 19769435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033792.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033792.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033701.2", "url": "https://www.ensembl.org/id/ENSBTAP00000033701.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A9M4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "FAM63A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELQSELGAMLTTTGDDAQCSESSPEPCQLPQDTGGSEEGGDVPSASQRSPELQPAVEEEVPHPSTTEDPAEHQESRSRGAQEELPTPGESDASPGGAPQAAAEPPSARSPTREPEPDFYCVKWITWKGERTPIITQSENGPCPLLAIMNILFLQWKVKLPPQKEVVTSDELMAHLGDCILSIKPHEKSEGLQLNFQQNVNDTMMVLPKLSTGLDVNVRFTGVSDFEYTPECIVFDLLNVPLYHGWLVDPQSPEVVRAVGKLSYNQLVEKIITCKHSGDPNLVTEGPPVLAGDGPGLPAGGARGVGEPSQRGRRQLLLRHAVPPQPCPGQRGGRAGAEPAGPGLHDGPIPAAAAGPGPLSTQRPGAGTAAAAGGVPAAAAAAPPGPPAGPSTAGRPPDTGAETAAQTELGLHPPVADPPGTPPSCRDPLQVLGTMWCEMWGWGGPSLHSAGTLPVFPVALTWG", "length": 463 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7F7Q8-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Mindy1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEQPQAEPPAPSKASSVETVESEKHEALSGPEKNPQDKPRDKGGAEADGAAGEQEPEDQALPPAEDADSGNLECPPPEASSSTCGTSPETETREMSSKPQELPQSPRTQQPDLDLYCVKWIPWKGERTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEMITSDELMTHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSIFDLLGIPLYHGWLVDPQFVFAPPHPSPQSPEAVSAVGKLSYNQLVEKIITCKHSSDLNLVTEGLIAEQFLETTAAQLTYHGLCELTATAKEDELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKSHGAEGGGGSPEKQLQVDQDYLIALSLQQQQPQGTLGLSDLELAQQLQQEEYQQQQAVQPGHTRAPSPQGRGTTSGRPAGDRRQRSKPESDCVLL", "length": 480 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SS98-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "MINDY1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEHHQPEHPASGKAGIAEAVSPENHEVPSEPDEHPQDKDAREADGAAGEQEPEDQASLLAQGHDNLESPPPDASSCQTGPAQGTWPEVETVGACSRPQELPQSPRARQPELDFYCVKWIPWKGERTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGDCLLSIKPQEKSEGLQLNFQQNVEDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSIFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMIKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGRGSPENQRQVDQDYLIALSLQQQQPPPQGTSGLSDLELAQQLQQEEYQQHQAAQPVPAPAPSLQGRGATSGRPAAERRQRPKQESDCVLL", "length": 469 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08930-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase MIY1", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDLSFTTKSVKINGQNHRILLQNENGPCALLALANILILSPDHTRFSNELIRLVNKGSQISLKELIEVLADIALQVTDKPSTDISELLSLLPRLHEGLNINPEFNGSFENTKEMSIFRLFNVDVVHGWVINSFINENIDEKLSHYSYESAQRILTQAADINCGISQDENSDEVLRDAMHLGLFLNESPTQLTAFGLLRLREKLLHNKFSILFRNDHFSTLFKYEDRLYTLVTDFGYKNCKDIVWQSLDSVDGSCDAFFAGNFSAAEVNGQQLSTDIERDFGTGNLLLEEIQQIENDKELAKQLQEQEQERVTKFEAKRKIHSHKKNSEIHAPVKKDKFKRRSSLLNAKASEKEKSECVVM", "length": 360 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5BJQ2-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-1", "gene_name": "Mindy1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQPQAECPAPSKTNSAETVESEKHEALSGPEKHPQDKDGADAAPEKHPQDKDGADAHGEAGKQKSGDQTLPPVQDGGNLECPPPEASSSPPGPACGIPSEVETTEACSRPQQLPQSPRIQQPDLDFYCVKWIPWKGERTPIITQSSNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVGDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGVPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIIICKHSSDSNLVTEGLIAEQFLETTAAQLTYHGLCELTATAKEDELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKSHGAEGGSGSPEKQLQVDQDYLIALSLQQQQQPQGMLGLSDLELAQQLQQEEYQQQQAVQPVRTRAPSSPGRGATSGRPAGERRQRSKTESDCVLL", "length": 482 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q76LS9-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-1", "gene_name": "Mindy1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQPQTENPAPSKATSAETVESENHEALSGPEKHPQDKDGADADGAAGEQEPGDQTLPPAQDGENLECPPPEASSSPPGPACGTSPKVETAEVCSRPQELPQSPRIQQPELDFYCVKWIPWKGERTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSIFDLLGIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKIITCKHSSDSNLVTEGLVAEQFLETTAAQLTYHGLCELTAAATEDELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKSHGAEGGGGSPEKQLQVDQDYLIALSLQQQQQPQGTLGLSDLELAQQLQQEEYQQQQAVQPVRTRAPSPQGRGATSGRPAGERRQRSKTESDCVLL", "length": 468 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N5J2-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-1", "gene_name": "MINDY1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL", "length": 469 }, "evidence": [ { "id": "F1N422", "url": "https://omabrowser.org/oma/group/F1N422/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "K48-linked polyubiquitin modification-dependent protein binding", "id": "GO:0036435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036435", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" }, { "name": "cysteine-type carboxypeptidase activity", "id": "GO:0016807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016807", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" }, { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" }, { "name": "K48-linked deubiquitinase activity", "id": "GO:1990380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990380", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" }, { "name": "histone deubiquitinase activity", "id": "GO:0140934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140934", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1N422", "url": "https://www.uniprot.org/uniprotkb/F1N422" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N422-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 469, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N422-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N422" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N422" }, { "id": "PF04424", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04424" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MINDY deubiquitinase", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 364, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N439-1", "uniprot_ac": "F1N439", "uniprot_id": "F1N439_BOVIN", "mass": { "chemical_mass": 131955.0, "monoisotopic_mass": 131955.0 }, "refseq": { "ac": "NP_001193032", "name": "syntaxin-binding protein 5-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193032" }, "gene_names": [ { "name": "STXBP5L", "type": "recommended", "evidence": [ { "id": "F1N439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ] }, { "name": "STXBP5L", "type": "synonym", "evidence": [ { "id": "NP_001193032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193032" } ] } ], "protein_names": [ { "name": "Syntaxin-binding protein 5-like", "type": "recommended", "evidence": [ { "id": "F1N439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N439/entry#names_and_taxonomy" } ] }, { "name": "Lethal(2) giant larvae protein homolog 4", "type": "synonym", "evidence": [ { "id": "F1N439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N439/entry#names_and_taxonomy" } ] }, { "name": "Tomosyn-2", "type": "synonym", "evidence": [ { "id": "F1N439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N439/entry#names_and_taxonomy" } ] }, { "name": "hCG16779-like", "type": "synonym", "evidence": [ { "id": "NP_001193032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193032" } ] }, { "name": "syntaxin binding protein 5 like", "type": "synonym", "evidence": [ { "id": "NP_001193032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193032" } ] }, { "name": "syntaxin-binding protein 5-like", "type": "synonym", "evidence": [ { "id": "NP_001193032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193032" } ] } ], "function": [ { "annotation": "Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth.", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439#function" }, { "database": "UniProtKB", "id": "ARBA00059292", "url": "https://www.uniprot.org/uniprotkb/ARBA00059292#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STXBP5L", "url": "https://www.uniprot.org/uniprotkb/F1N439", "locus": { "chromosome": "1", "start_pos": 65930952, "end_pos": 65607669, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001918", "url": "https://www.ensembl.org/id/ENSBTAG00000001918" } ] } } ], "crossref": [ { "id": "F1N439", "url": "https://alphafold.ebi.ac.uk/entry/F1N439", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15893", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15893", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536735", "url": "https://www.ncbi.nlm.nih.gov/gene/536735", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000664", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000664", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536735", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536735", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SERTMDC", "url": "https://omabrowser.org/oma/group/SERTMDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N439", "url": "https://www.orthodb.org/?gene=F1N439", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10241:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10241:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193032", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N439-1", "url": "https://www.uniprot.org/uniprotkb/F1N439-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSTHPAGTAGILREEIQETLTSDYFQICKTVRHGFPYQPTTLAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTVPHGKSQREGRKPESCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSTGVKHKKQGYSNKEWPISGGAWNLGTQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPYAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDIEDIITPEPETSPPFPDLSSQLPSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDIYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPQELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKINRWGPGRPPFRKAQSAACMEISLPVTTEESRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTISPCLFVGTSLGMVLIISLNLPSADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRTGGLMQPPYEVWRDPNNIDENEKSWRRKLVMNCPSPSQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQADVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEATAGKASRSLAQHIPGPGGIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF", "length": 1185, "header": "tr|F1N439-1|F1N439_BOVIN Isoform 1 of Syntaxin-binding protein 5-like OS=Bos taurus OX=9913 GN=STXBP5L PE=3 SV=2 CANONICAL=F1N439-1" }, "isoforms": [ { "isoform_ac": "F1N439-1", "url": "https://www.uniprot.org/uniprotkb/F1N439/entry", "sequence": { "sequence": "MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSTHPAGTAGILREEIQETLTSDYFQICKTVRHGFPYQPTTLAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTVPHGKSQREGRKPESCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSTGVKHKKQGYSNKEWPISGGAWNLGTQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPYAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDIEDIITPEPETSPPFPDLSSQLPSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDIYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPQELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKINRWGPGRPPFRKAQSAACMEISLPVTTEESRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTISPCLFVGTSLGMVLIISLNLPSADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRTGGLMQPPYEVWRDPNNIDENEKSWRRKLVMNCPSPSQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQADVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEATAGKASRSLAQHIPGPGGIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF", "length": 1185, "header": "tr|F1N439-1|F1N439_BOVIN Isoform 1 of Syntaxin-binding protein 5-like OS=Bos taurus OX=9913 GN=STXBP5L PE=3 SV=2 CANONICAL=F1N439-1" }, "locus": { "chromosome": "1", "start_pos": 65930001, "end_pos": 65608795, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002496.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002496.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002496.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002496.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536735", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536735", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AM85-1", "protein_name": "Syntaxin-binding protein 5-like", "gene_name": "STXBP5L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPGGTAGVLREEIQETLTSDYFQICKTVRHGFPYQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGRQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGRKPESCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGTQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPYAVQMMYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDIEDIITPEPETSPPFPDLSSQLPSSRSLSGSTNTVSSEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAISSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCGSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTAEESRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTISPCLFVGTSLGMVLIISLNLPSTDEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRTGGLMQPPYEVWRDPNNIDENEKSWRRKLVMNFPSPSQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF", "length": 1186 }, "evidence": [ { "id": "F1N439", "url": "https://omabrowser.org/oma/group/F1N439/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LU94-1", "protein_name": "Syntaxin-binding protein 5-like", "gene_name": "Stxbp5l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKKFNFRKVLDGLTASSPGSGSSSNSGGVGSGSVHPGGTAGALREEIQESLTSDYFQICKTVRHGFPYQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTVPHGKSQREGRKSEPCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQTNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSTKEWPVSGGAWNLGAQTYPEIIITGHADGSIKFWDASAMTLQMLYKLKTSKVFEKQKVGDGKQTCEIVEEDPFAVQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQCDVEDIITPEPETSPPFPDLSSQLPSSRSLSGSTNTVSSEGVTKDSIPCLSVKTRPVRMPPGYQADLVIQLVWVDGEPPQQITSLAISSAYGIVAFGNCTGLVVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEEARENSYNRSRSSSISSIDKDSKEAVTALYFMESFARKNDSTVSPCLFVGTSLGMVLLISLNLPSSDEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRTGSLMQPPYEVWRDPNNTDENEKTWKRKLVMNYSTSSQETGDHQYTIICSEKQAKIFSLPSQTCLYVHNITETSFILQAEVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNIQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEATAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF", "length": 1183 }, "evidence": [ { "id": "F1N439", "url": "https://omabrowser.org/oma/group/F1N439/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5DQR4-1", "protein_name": "Syntaxin-binding protein 5-like", "gene_name": "Stxbp5l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKKFNFRKVLDGLTASSPGSGSSSGSNSGGAGSGSVHPGGTAGLPREEIQESLTSDYFQICKTVRHGFPYQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTVPHGKSQREGRKSESCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQTNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPVSGGAWNLGAQTYPEIIITGHADGTIKFWDASAMTLQMLYKLKTSKVFEKQKAGEGKQTCELVEEDPFAVQMIYWCPESRIFCVSGVSAYVIIYKFSRHEVTTEIVSLEVRLQCDVEDIITPEPETSPPFPDLSSQLPPSRSLSGSTNTVSSEGVTKDSIPCLSVKTRPVRMPPGYQADLVIQLVWVDGEPPQQITSLSISSAYGIVAFGNCTGLVVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNRQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEETRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTVSPCLFVGTSLGMVVLISLNLPSSDEQRFTEPVVVLPSGTFLSLKGAVLTFSCMDRTGSLMQPPYEVWRDPNNTDENEKTWKRKLVMNYSSSSQEMGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQADVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNIQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF", "length": 1185 }, "evidence": [ { "id": "F1N439", "url": "https://omabrowser.org/oma/group/F1N439/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2K9-1", "protein_name": "Syntaxin-binding protein 5-like", "gene_name": "STXBP5L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF", "length": 1186 }, "evidence": [ { "id": "F1N439", "url": "https://omabrowser.org/oma/group/F1N439/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "myosin II binding", "id": "GO:0045159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045159", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "neuronal dense core vesicle", "id": "GO:0098992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098992", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle exocytosis", "id": "GO:2000300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000300", "evidence": [ { "database": "UniProtKB", "id": "F1N439", "url": "https://www.uniprot.org/uniprotkb/F1N439" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 813, "end_pos": 815, "annotation": "n_glycosylation_sequon" }, { "start_pos": 844, "end_pos": 846, "annotation": "n_glycosylation_sequon" }, { "start_pos": 972, "end_pos": 974, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N439-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1185, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N439-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N439" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N439" }, { "id": "PS50892", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50892" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "V-SNARE coiled-coil homology", "eco_id": "ECO_0000259", "start_pos": 1120, "end_pos": 1180, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 230, "end_pos": 232 }, { "start_pos": 732, "end_pos": 734 }, { "start_pos": 813, "end_pos": 815 }, { "start_pos": 844, "end_pos": 846 }, { "start_pos": 972, "end_pos": 974 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N475-1", "uniprot_ac": "F1N475", "uniprot_id": "F1N475_BOVIN", "mass": { "chemical_mass": 34554.0, "monoisotopic_mass": 34554.0 }, "refseq": { "ac": "NP_001376678", "name": "olfactory receptor family 8 subfamily S member 24", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376678" }, "gene_names": [ { "name": "OR8S24", "type": "recommended", "evidence": [ { "id": "F1N475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N475" } ] }, { "name": "OR8S24", "type": "synonym", "evidence": [ { "id": "NP_001376678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376678" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N475/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 8S1", "type": "synonym", "evidence": [ { "id": "NP_001376678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376678" } ] }, { "name": "olfactory receptor family 8 subfamily S member 24", "type": "synonym", "evidence": [ { "id": "NP_001376678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376678" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376678" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8S24", "url": "https://www.uniprot.org/uniprotkb/F1N475", "locus": { "chromosome": "5", "start_pos": 31486313, "end_pos": 31487248, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052728", "url": "https://www.ensembl.org/id/ENSBTAG00000052728" } ] } } ], "crossref": [ { "id": "F1N475", "url": "https://alphafold.ebi.ac.uk/entry/F1N475", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15229", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15229", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504567", "url": "https://www.ncbi.nlm.nih.gov/gene/504567", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504567", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504567", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DFCESHI", "url": "https://omabrowser.org/oma/group/DFCESHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N475", "url": "https://www.orthodb.org/?gene=F1N475", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376678", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N475-1", "url": "https://www.uniprot.org/uniprotkb/F1N475-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLGNHTIVTQFLLLGLSTDPHIQALLFVLFLEIYLLTLMGNLMMLLVIRADSHLHMPMFFFLSHLSLLDLCLSSVTVPKMLKDLLSETKTISLRGCLAQGFFVLITAGTECFLLSAMAYDRYAAICHPLLYGQMMKKQLCVQLVWGSWGLASLNAFINTLLAANLDFCENHTISHYSCEVPSLFPLSCSDVSINLIVLLCSSLMHGFGTLLPIVFSYAHIVSTILSISSTSGRSKTFSTCSSHLTAVSFFFGSGFLRYLMPTSGSPLELIFSVQYGVVTPMVNPLIYSLRNKEVKAAVRRTLGKYMRWSR", "length": 311, "header": "tr|F1N475-1|F1N475_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8S24 PE=3 SV=3 CANONICAL=F1N475-1" }, "isoforms": [ { "isoform_ac": "F1N475-1", "url": "https://www.uniprot.org/uniprotkb/F1N475/entry", "sequence": { "sequence": "MTLGNHTIVTQFLLLGLSTDPHIQALLFVLFLEIYLLTLMGNLMMLLVIRADSHLHMPMFFFLSHLSLLDLCLSSVTVPKMLKDLLSETKTISLRGCLAQGFFVLITAGTECFLLSAMAYDRYAAICHPLLYGQMMKKQLCVQLVWGSWGLASLNAFINTLLAANLDFCENHTISHYSCEVPSLFPLSCSDVSINLIVLLCSSLMHGFGTLLPIVFSYAHIVSTILSISSTSGRSKTFSTCSSHLTAVSFFFGSGFLRYLMPTSGSPLELIFSVQYGVVTPMVNPLIYSLRNKEVKAAVRRTLGKYMRWSR", "length": 311, "header": "tr|F1N475-1|F1N475_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8S24 PE=3 SV=3 CANONICAL=F1N475-1" }, "locus": { "chromosome": "5", "start_pos": 31487248, "end_pos": 31486316, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021705.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021705.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021705.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021705.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504567", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504567", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BNU3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110260592", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALGNHSTITEFLFRGLSADPHIQAALFVLFLEIYLLTVTGNLMMMLVIGADSHLHTPMCFFLSHLSFLDLCLSSVTVPKMLKDLLFEKKSISVKGCLAQSFFVFTIAGTECFLLSAMAYDRYAAICYPLLYGQMMKKQLCVQLVWGSWGLGSLNAFINILLASNLDFCGNHIISHYSCEMPSLYLLSCSDVSTNLLVLLCSSLLHGFGTLLPIFFSYARIVSTILSISSTSGRSKTFSTCSSHLIAVSFFFGSGFLRYLTPTSGTPLELIFSVQYCVVTPMLNPLIYSLKNREVKAGVRRTLRKYLPWSR", "length": 311 }, "evidence": [ { "id": "F1N475", "url": "https://omabrowser.org/oma/group/F1N475/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N475", "url": "https://www.uniprot.org/uniprotkb/F1N475" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N475-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N475-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N475" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N475" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N481-1", "uniprot_ac": "F1N481", "uniprot_id": "F1N481_BOVIN", "mass": { "chemical_mass": 37175.0, "monoisotopic_mass": 37175.0 }, "refseq": {}, "gene_names": [ { "name": "OR8H13", "type": "recommended", "evidence": [ { "id": "F1N481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N481/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8H13", "url": "https://www.uniprot.org/uniprotkb/F1N481", "locus": { "chromosome": "15", "start_pos": 79057631, "end_pos": 79056621, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001291", "url": "https://www.ensembl.org/id/ENSBTAG00000001291" } ] } } ], "crossref": [ { "id": "F1N481", "url": "https://alphafold.ebi.ac.uk/entry/F1N481", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001291", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001291", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IEIMIYI", "url": "https://omabrowser.org/oma/group/IEIMIYI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N481-1", "url": "https://www.uniprot.org/uniprotkb/F1N481-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRNITQVSDFILMGLTDSEEIRLVLFTLFLLIYLITVLGNVGMILIISLDSRLHTPMYFFLSHLSFLDLSYSSVITPKTLDNLLNSTKNISYPNCFIQMSCFIFLGATECFLLSSMAYDRYAAICNPLHYPIVMYTRRCWSLVFGCYLIGFMDSFVNGLCMSRLHFCKSNIIFHFFCDLSPILALSCTDTHDIEIIISTFAGSSLVLSLLTIAVSYVSILSTILKITSTSSKQKVFSTCASHLLGVTVFYGTMIFTYLKPSKSYSLGKDQIASVFYTIVIPMLNPLIYSLRNKEVKNALSRVMQKMKVAPSCPILCDPMDSIVHGILQA", "length": 331, "header": "tr|F1N481-1|F1N481_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8H13 PE=3 SV=4 CANONICAL=F1N481-1" }, "isoforms": [ { "isoform_ac": "F1N481-1", "url": "https://www.uniprot.org/uniprotkb/F1N481/entry", "sequence": { "sequence": "MGRRNITQVSDFILMGLTDSEEIRLVLFTLFLLIYLITVLGNVGMILIISLDSRLHTPMYFFLSHLSFLDLSYSSVITPKTLDNLLNSTKNISYPNCFIQMSCFIFLGATECFLLSSMAYDRYAAICNPLHYPIVMYTRRCWSLVFGCYLIGFMDSFVNGLCMSRLHFCKSNIIFHFFCDLSPILALSCTDTHDIEIIISTFAGSSLVLSLLTIAVSYVSILSTILKITSTSSKQKVFSTCASHLLGVTVFYGTMIFTYLKPSKSYSLGKDQIASVFYTIVIPMLNPLIYSLRNKEVKNALSRVMQKMKVAPSCPILCDPMDSIVHGILQA", "length": 331, "header": "tr|F1N481-1|F1N481_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8H13 PE=3 SV=4 CANONICAL=F1N481-1" }, "locus": { "chromosome": "15", "start_pos": 79057628, "end_pos": 79056636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055982.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055982.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052886.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052886.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JXQ4-1", "protein_name": "Olfactory receptor", "gene_name": "Or8h10b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTWNYTKESDFILMGLTDSKELQLVLAVLFLLIYLVTVLGNTGMMLIIRLDARLHTPMYFFLTHLSFLDLCYSTVITPKTLQNLLTSNKIISFIGCFTQMYGFVLLAAAECFLLASMSYDRYVAICNPLHYPVIMSTRFCSALLTGSYMIGTLDATVNILCMNTLYFCRPKVIHHFFCDTSPILVLSCNDTHNIEIIIFIFAGSTLMVSVTTISASYMSILSTILKINSTSGKHKAFSTCASHLLGVTVFYGSMIFTYLKPSNSYSLGKDQVASVFYTVVIPMLNPLIYSLRNKEVKNAVHRVIKKQENSRLKFRVALSN", "length": 321 }, "evidence": [ { "id": "F1N481", "url": "https://omabrowser.org/oma/group/F1N481/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NGG4-1", "protein_name": "Olfactory receptor 8H1", "gene_name": "OR8H1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRRNNTNVPDFILTGLSDSEEVQMALFILFLLIYLITMLGNVGMILIIRLDLQLHTPMYFFLTHLSFIDLSYSTVITPKTLANLLTSNYISFMGCFAQMFFFVFLGAAECFLLSSMAYDRYVAICSPLRYPVIMSKRLCCALVTGPYVISFINSFVNVVWMSRLHFCDSNVVRHFFCDTSPILALSCMDTYDIEIMIHILAGSTLMVSLITISASYVSILSTILKINSTSGKQKALSTCASHLLGVTIFYGTMIFTYLKPRKSYSLGRDQVASVFYTIVIPMLNPLIYSLRNKEVKNALIRVMQRRQDSR", "length": 311 }, "evidence": [ { "id": "F1N481", "url": "https://omabrowser.org/oma/group/F1N481/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "F1N481", "url": "https://www.uniprot.org/uniprotkb/F1N481" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N481-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 331, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N481-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N481" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N481" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 87, "end_pos": 89 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N486-1", "uniprot_ac": "F1N486", "uniprot_id": "F1N486_BOVIN", "mass": { "chemical_mass": 34326.0, "monoisotopic_mass": 34326.0 }, "refseq": { "ac": "NP_001376968", "name": "olfactory receptor family 2 subfamily W member 4", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376968" }, "gene_names": [ { "name": "OR2W4", "type": "recommended", "evidence": [ { "id": "F1N486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N486" } ] }, { "name": "OR2W4", "type": "synonym", "evidence": [ { "id": "NP_001376968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376968" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N486/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 2 subfamily W member 4", "type": "synonym", "evidence": [ { "id": "NP_001376968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376968" } ] }, { "name": "putative olfactory receptor 2W6", "type": "synonym", "evidence": [ { "id": "NP_001376968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376968" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376968" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2W4", "url": "https://www.uniprot.org/uniprotkb/F1N486", "locus": { "chromosome": "23", "start_pos": 30882438, "end_pos": 30881509, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039145", "url": "https://www.ensembl.org/id/ENSBTAG00000039145" } ] } } ], "crossref": [ { "id": "F1N486", "url": "https://alphafold.ebi.ac.uk/entry/F1N486", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15434", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15434", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522315", "url": "https://www.ncbi.nlm.nih.gov/gene/522315", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522315", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522315", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCFSTSC", "url": "https://omabrowser.org/oma/group/LCFSTSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376968", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N486-1", "url": "https://www.uniprot.org/uniprotkb/F1N486-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKSNDSSEYGFILVGFSDRPKLEMVLFIVNFTLYSVAVLGNSAIILVCILDSRLHTPMYFFLANLSFLDLCFSTSCVPQMLVNLWGPDKTISYAGCVVQLFSFLSVGGVECLLLAVMAYDRYAAVCRPLYYTVIMHPQLCLRLVAVAWGSGLVNAIVMSPLTMTLSRCGQRRVNHFLCEMPALIKMACVDARAVEMLGFTFAILIVLLPLTLILVSYGYIAAAVLRIKSAAGRRKAFNTCSSHLTVVSLFYGSIIYMYMQPGNSSSQDQGKFLTLFYNLVTPMLNPLIYTLRNKEVKGALKKVLGRQQ", "length": 309, "header": "tr|F1N486-1|F1N486_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2W4 PE=3 SV=3 CANONICAL=F1N486-1" }, "isoforms": [ { "isoform_ac": "F1N486-1", "url": "https://www.uniprot.org/uniprotkb/F1N486/entry", "sequence": { "sequence": "MEKSNDSSEYGFILVGFSDRPKLEMVLFIVNFTLYSVAVLGNSAIILVCILDSRLHTPMYFFLANLSFLDLCFSTSCVPQMLVNLWGPDKTISYAGCVVQLFSFLSVGGVECLLLAVMAYDRYAAVCRPLYYTVIMHPQLCLRLVAVAWGSGLVNAIVMSPLTMTLSRCGQRRVNHFLCEMPALIKMACVDARAVEMLGFTFAILIVLLPLTLILVSYGYIAAAVLRIKSAAGRRKAFNTCSSHLTVVSLFYGSIIYMYMQPGNSSSQDQGKFLTLFYNLVTPMLNPLIYTLRNKEVKGALKKVLGRQQ", "length": 309, "header": "tr|F1N486-1|F1N486_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2W4 PE=3 SV=3 CANONICAL=F1N486-1" }, "locus": { "chromosome": "23", "start_pos": 30882435, "end_pos": 30881509, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054426.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054426.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052879.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052879.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522315", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522315", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RPI2-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERSNDSFEYDFILVGFSDRPKLEMVLFTVNLILYSVAVLGNSTIILLCILDSRLHTPMYFFLANLSFLDLCFSTSCIPQMLVNLWGPEKTISYAGCVVQLFSFLSIGGIECILLAVMAYDRYAAVCKPLHYMVIMHPQLCLQLVAVAWGSGLVNAIVMSPLTMTLSRCGRRRVNHFLCEMPALIKMACVDARAVEMLAFTFAILIVLLPLTLILISYGYIAAAVLRIKSAAGRQKAFNTCSSHLTVVFLFYGSIIYMYMQPGNSSSQDQGKFLTLFYNLVTPMLNPLIYTLRNKEVKGALKKVLGKQQ", "length": 309 }, "evidence": [ { "id": "F1N486", "url": "https://omabrowser.org/oma/group/F1N486/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5SZZ8-1", "protein_name": "Olfactory receptor", "gene_name": "Or2w4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKSNDSSEYGFILEGFSDRPRLEMVLFIVNFTLYSVAVLGNITIILVCILDPRLHTPMYFFLANLSFLDLCFSTSCIPQMLVNLWGPDKTISYAGCVVQLFSFLSIGSVECILLAVMAYDRYAAVCKPLHYMVIMHPQLCVRLMAVAWGVGLANAIIMSPLAMTLPRCGRRRINHFLCELPALIKMACVDARPVEMLSFTLAILIVLLPLTLILVSYGYIAAAVLRIKSAAGRWKAFNTCSSHLTVVSLFYGSIIYMYMQPGNSSSQDQGKFLTLFYNLVTPMLNPLIYTLRNKEMKGALKKVCGRH", "length": 308 }, "evidence": [ { "id": "F1N486", "url": "https://omabrowser.org/oma/group/F1N486/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1N486", "url": "https://www.uniprot.org/uniprotkb/F1N486" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N486-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N486-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N486" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N486" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 264, "end_pos": 266 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4A3-1", "uniprot_ac": "F1N4A3", "uniprot_id": "F1N4A3_BOVIN", "mass": { "chemical_mass": 23568.0, "monoisotopic_mass": 23568.0 }, "refseq": { "ac": "XP_015329727", "name": "class E basic helix-loop-helix protein 23", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329727" }, "gene_names": [ { "name": "BHLHE23", "type": "recommended", "evidence": [ { "id": "F1N4A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ] }, { "name": "BHLHE23", "type": "synonym", "evidence": [ { "id": "XP_015329727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329727" } ] } ], "protein_names": [ { "name": "Basic helix-loop-helix family member e23", "type": "synonym", "evidence": [ { "id": "F1N4A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A3/entry#names_and_taxonomy" } ] }, { "name": "class E basic helix-loop-helix protein 23", "type": "synonym", "evidence": [ { "id": "XP_015329727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329727" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BHLHE23", "url": "https://www.uniprot.org/uniprotkb/F1N4A3", "locus": { "chromosome": "13", "start_pos": 54423251, "end_pos": 54422583, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010873", "url": "https://www.ensembl.org/id/ENSBTAG00000010873" } ] } } ], "crossref": [ { "id": "F1N4A3", "url": "https://alphafold.ebi.ac.uk/entry/F1N4A3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539207", "url": "https://www.ncbi.nlm.nih.gov/gene/539207", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539207", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539207", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NCPEKCT", "url": "https://omabrowser.org/oma/group/NCPEKCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4A3", "url": "https://www.orthodb.org/?gene=F1N4A3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19290:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19290:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015329727", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329727", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4A3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4A3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELKSLSGDAYLELSHGYAAAGLAYGAARGPEAARGYGMPGTGSDLPAASAPRVPAAAAESSGEQSGDEDDAFERRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAYLNHGQGLATPVAAAPLTPFGQAALYPFSASAALPCPDKCAAFSGTPSALCKHCNEKP", "length": 222, "header": "tr|F1N4A3-1|F1N4A3_BOVIN Isoform 1 of Basic helix-loop-helix family member e23 OS=Bos taurus OX=9913 GN=BHLHE23 PE=4 SV=2 CANONICAL=F1N4A3-1" }, "isoforms": [ { "isoform_ac": "F1N4A3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4A3/entry", "sequence": { "sequence": "MAELKSLSGDAYLELSHGYAAAGLAYGAARGPEAARGYGMPGTGSDLPAASAPRVPAAAAESSGEQSGDEDDAFERRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAYLNHGQGLATPVAAAPLTPFGQAALYPFSASAALPCPDKCAAFSGTPSALCKHCNEKP", "length": 222, "header": "tr|F1N4A3-1|F1N4A3_BOVIN Isoform 1 of Basic helix-loop-helix family member e23 OS=Bos taurus OX=9913 GN=BHLHE23 PE=4 SV=2 CANONICAL=F1N4A3-1" }, "locus": { "chromosome": "13", "start_pos": 54423248, "end_pos": 54422583, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014445.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014445.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014445.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014445.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 210, "start_aa": "Thr", "end_pos": 210, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr210", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539207", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539207", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZU26-1", "protein_name": "Basic helix-loop-helix family, member e23", "gene_name": "Bhlhe23", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAELKSLSGDSYLALSHGYAATSHAYAAARGPETTRGFGASGPGGDLPAAPASRVPAATVESSGEQSGDEDEAFERRRRRRGPGVAVDARRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQSLAAPVAAAPLTPFGQAAVYPFTAGAALGPCPDKCATFSGSPSALCKHCGEKP", "length": 223 }, "evidence": [ { "id": "F1N4A3", "url": "https://omabrowser.org/oma/group/F1N4A3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BGW3-1", "protein_name": "Class E basic helix-loop-helix protein 23", "gene_name": "Bhlhe23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELKSLSGDSYLALSHSYTATGHAYAAARGPETTRGFGASGPGGDLPAAPASRVPAATVESSGEQSGDEDEAFERRRRRRGSGVAVDARRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQGLAAPVAAAPLTPFGQAAIYPFSAGTALGPCPDKCATFSGSPSALCKHCGEKP", "length": 223 }, "evidence": [ { "id": "F1N4A3", "url": "https://omabrowser.org/oma/group/F1N4A3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NDY6-1", "protein_name": "Class E basic helix-loop-helix protein 23", "gene_name": "BHLHE23", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEKP", "length": 225 }, "evidence": [ { "id": "F1N4A3", "url": "https://omabrowser.org/oma/group/F1N4A3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" }, { "name": "axon development", "id": "GO:0061564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061564", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" }, { "name": "sensory organ development", "id": "GO:0007423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007423", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "F1N4A3", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4A3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 222, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4A3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4A3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4A3" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 98, "end_pos": 152, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 210 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4D3-1", "uniprot_ac": "F1N4D3", "uniprot_id": "F1N4D3_BOVIN", "mass": { "chemical_mass": 47336.0, "monoisotopic_mass": 47336.0 }, "refseq": {}, "gene_names": [ { "name": "CDC34", "type": "recommended", "evidence": [ { "id": "F1N4D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4D3" } ] } ], "protein_names": [ { "name": "E2 ubiquitin-conjugating enzyme", "type": "recommended", "evidence": [ { "id": "F1N4D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4D3/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.23", "type": "synonym", "evidence": [ { "id": "F1N4D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4D3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4D3", "url": "https://www.uniprot.org/uniprotkb/F1N4D3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC34", "url": "https://www.uniprot.org/uniprotkb/F1N4D3", "locus": { "chromosome": "7", "start_pos": 43180454, "end_pos": 43172967, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002098", "url": "https://www.ensembl.org/id/ENSBTAG00000002098" } ] } } ], "crossref": [ { "id": "F1N4D3", "url": "https://alphafold.ebi.ac.uk/entry/F1N4D3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002098", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002098", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23803", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23803", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4D3", "url": "https://www.orthodb.org/?gene=F1N4D3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24067", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24067", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N4D3", "url": "https://www.uniprot.org/uniprotkb/F1N4D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4D3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4D3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VGVRAQGAARIRTLIWGSGGTGAESRLQKVRRVGRGLRATEPSPLERLGRPDRVPGGETEARAGTAPARPRPAPGRHKKAPKARRAGQSGAALPCPRPHAQASGELVRAGAAAAFQGIGSAKAPARAAPGSRRRARRPGEGSLPGVPRGRARRRDRGGRRAGALGGGGARQRRQAPGGGAERVERPGTPGGGGGGGGGGGGGAEEEAGPGPSRGPAAPRPAPRAPGPSAAAMARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRTHTHLLCRCACGAVETCACGPASRPHGESSREPSGTIGSRSWGPRWMQSGMA", "length": 449, "header": "tr|F1N4D3-1|F1N4D3_BOVIN Isoform 1 of E2 ubiquitin-conjugating enzyme OS=Bos taurus OX=9913 GN=CDC34 PE=3 SV=3 CANONICAL=F1N4D3-1" }, "isoforms": [ { "isoform_ac": "F1N4D3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4D3/entry", "sequence": { "sequence": "VGVRAQGAARIRTLIWGSGGTGAESRLQKVRRVGRGLRATEPSPLERLGRPDRVPGGETEARAGTAPARPRPAPGRHKKAPKARRAGQSGAALPCPRPHAQASGELVRAGAAAAFQGIGSAKAPARAAPGSRRRARRPGEGSLPGVPRGRARRRDRGGRRAGALGGGGARQRRQAPGGGAERVERPGTPGGGGGGGGGGGGGAEEEAGPGPSRGPAAPRPAPRAPGPSAAAMARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRTHTHLLCRCACGAVETCACGPASRPHGESSREPSGTIGSRSWGPRWMQSGMA", "length": 449, "header": "tr|F1N4D3-1|F1N4D3_BOVIN Isoform 1 of E2 ubiquitin-conjugating enzyme OS=Bos taurus OX=9913 GN=CDC34 PE=3 SV=3 CANONICAL=F1N4D3-1" }, "locus": { "chromosome": "7", "start_pos": 43179450, "end_pos": 43173166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002707.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002707.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002707.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002707.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N4D3", "url": "https://www.uniprot.org/uniprotkb/F1N4D3" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "evidence": [ { "database": "UniProtKB", "id": "F1N4D3", "url": "https://www.uniprot.org/uniprotkb/F1N4D3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4D3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 449, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4D3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4D3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4D3" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 239, "end_pos": 405, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.23", "ec_name": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "2.3.2.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.23" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4E7-1", "uniprot_ac": "F1N4E7", "uniprot_id": "F1N4E7_BOVIN", "mass": { "chemical_mass": 81387.0, "monoisotopic_mass": 81387.0 }, "refseq": {}, "gene_names": [ { "name": "CATSPER1", "type": "recommended", "evidence": [ { "id": "F1N4E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ] } ], "protein_names": [ { "name": "Cation channel sperm-associated protein 1", "type": "recommended", "evidence": [ { "id": "F1N4E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CATSPER1", "url": "https://www.uniprot.org/uniprotkb/F1N4E7", "locus": { "chromosome": "29", "start_pos": 44104931, "end_pos": 44113273, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014720", "url": "https://www.ensembl.org/id/ENSBTAG00000014720" } ] } } ], "crossref": [ { "id": "F1N4E7", "url": "https://alphafold.ebi.ac.uk/entry/F1N4E7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014720", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014720", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4E7", "url": "https://www.orthodb.org/?gene=F1N4E7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47193", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47193", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47193:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47193:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1300642", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300642", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4E7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAKAQNEADTDNSDVLSHPSSSTPYHRPGHGGVHHHHQGASRHHGESHHHGLSHHRGGPHHPDEFQDFHSNVFSHHAHRSYHSPNHGESHHHGVDHGSTSLSQDPSRDTLISHQSYGEDHFDNEHHHGSRRHHGRSRQHREPNHHGGFHHHAEVPDYSGLHRQSEAYHHKDSTQSSSRSHLSEAYHHGGHHHRRPTSMMSYHQGPPHHGEHHHREHQHREHQHGTHPHDYPHRDQHHGEYRHGSSQLFGSYTPHAVTLGSLSSAYSRPAVFQPSKPDRKSSAFSLARSLSTVNSHPSETSNKVYPQDSSSKTSESCPEEDEHVQKRKVGRALRTHKKVHSSDFLYWLWEKLSQLIWGLRRMLRKLVDSLAFETFIIFIVCLNTIMLVAQTFAEVEVRGEWYFTALDYIFLSIYMVEAVLKIIALGLAYFLDPWNNLDFFIMVVGTLDFVLIQVNSSSTRAIHNQSVFRIFRVFKTLRALRAIRVLRRLRFLTNLQEVTGTLARSLPSITAILILMFTCLFLFSVVLRALFRYSDPKRFQNIFTTIFTLFTMLTLDDWSLIYLDSRAQGAWYIIPILMIYIIIQYFIFLNLVIAVLVDNFQMALLKGLEKEKQEAAELHEKLLDDSVTKLMEAEPKEVLSEHTIQKQLIEKKFGAMTEKQLETLFHFLQLVAGVEHYQLKFRSQAAVIDEIVDTTFEAGEEDFRK", "length": 705, "header": "tr|F1N4E7-1|F1N4E7_BOVIN Isoform 1 of Cation channel sperm-associated protein 1 OS=Bos taurus OX=9913 GN=CATSPER1 PE=3 SV=4 CANONICAL=F1N4E7-1" }, "isoforms": [ { "isoform_ac": "F1N4E7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4E7/entry", "sequence": { "sequence": "MSAKAQNEADTDNSDVLSHPSSSTPYHRPGHGGVHHHHQGASRHHGESHHHGLSHHRGGPHHPDEFQDFHSNVFSHHAHRSYHSPNHGESHHHGVDHGSTSLSQDPSRDTLISHQSYGEDHFDNEHHHGSRRHHGRSRQHREPNHHGGFHHHAEVPDYSGLHRQSEAYHHKDSTQSSSRSHLSEAYHHGGHHHRRPTSMMSYHQGPPHHGEHHHREHQHREHQHGTHPHDYPHRDQHHGEYRHGSSQLFGSYTPHAVTLGSLSSAYSRPAVFQPSKPDRKSSAFSLARSLSTVNSHPSETSNKVYPQDSSSKTSESCPEEDEHVQKRKVGRALRTHKKVHSSDFLYWLWEKLSQLIWGLRRMLRKLVDSLAFETFIIFIVCLNTIMLVAQTFAEVEVRGEWYFTALDYIFLSIYMVEAVLKIIALGLAYFLDPWNNLDFFIMVVGTLDFVLIQVNSSSTRAIHNQSVFRIFRVFKTLRALRAIRVLRRLRFLTNLQEVTGTLARSLPSITAILILMFTCLFLFSVVLRALFRYSDPKRFQNIFTTIFTLFTMLTLDDWSLIYLDSRAQGAWYIIPILMIYIIIQYFIFLNLVIAVLVDNFQMALLKGLEKEKQEAAELHEKLLDDSVTKLMEAEPKEVLSEHTIQKQLIEKKFGAMTEKQLETLFHFLQLVAGVEHYQLKFRSQAAVIDEIVDTTFEAGEEDFRK", "length": 705, "header": "tr|F1N4E7-1|F1N4E7_BOVIN Isoform 1 of Cation channel sperm-associated protein 1 OS=Bos taurus OX=9913 GN=CATSPER1 PE=3 SV=4 CANONICAL=F1N4E7-1" }, "locus": { "chromosome": "29", "start_pos": 44113137, "end_pos": 44105045, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019586.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019586.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019586.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019586.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1300642", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300642", "resource": "Reactome", "description": "Sperm Motility And Taxes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" }, { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" }, { "name": "regulation of cilium beat frequency involved in ciliary motility", "id": "GO:0060296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060296", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium-activated cation channel activity", "id": "GO:0005227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" }, { "name": "voltage-gated calcium channel activity", "id": "GO:0005245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005245", "evidence": [ { "database": "UniProtKB", "id": "F1N4E7", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4E7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 705, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4E7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4E7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4E7" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 371, "end_pos": 602, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 455, "end_pos": 457 }, { "start_pos": 464, "end_pos": 466 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4G1-1", "uniprot_ac": "F1N4G1", "uniprot_id": "F1N4G1_BOVIN", "mass": { "chemical_mass": 34945.0, "monoisotopic_mass": 34945.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112447768", "type": "recommended", "evidence": [ { "id": "F1N4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" } ] } ], "protein_names": [ { "name": "Peptidase S1 domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1N4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4G1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4G1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112447768", "url": "https://www.uniprot.org/uniprotkb/F1N4G1", "locus": {} } ], "crossref": [ { "id": "F1N4G1", "url": "https://alphafold.ebi.ac.uk/entry/F1N4G1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040038", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040038", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N4G1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4G1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPYTSIQILPFVVLCCVMPWVSPPSSCFLLLVQCGQKMNTSEKSEVLEIIGGVPANIRDFPWQIRILENGSHLCGGSILSEWWILTAAHCFKSKNASTLEVTHGEENLDTQNLTKIKVDKLIIHNYFDSWFYLNDIALLLLKSPLSLGVRKVPICLSEVTAIERWRNCWVSGWGTTGDTETGLQKVNIQLIKWETCFELMPLLTKSMLCAGDLEGGKDACQGDSGGPLVCQKKTRKSKWYQLGIVSWGVGCGQKKQPGVYTQVSSYLSWIETKTKLSKRPYKHEPDSGYSLLLSPWAILVLYFLMFLLSP", "length": 311, "header": "tr|F1N4G1-1|F1N4G1_BOVIN Isoform 1 of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN=LOC112447768 PE=4 SV=4 CANONICAL=F1N4G1-1" }, "isoforms": [ { "isoform_ac": "F1N4G1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1/entry", "sequence": { "sequence": "MKPYTSIQILPFVVLCCVMPWVSPPSSCFLLLVQCGQKMNTSEKSEVLEIIGGVPANIRDFPWQIRILENGSHLCGGSILSEWWILTAAHCFKSKNASTLEVTHGEENLDTQNLTKIKVDKLIIHNYFDSWFYLNDIALLLLKSPLSLGVRKVPICLSEVTAIERWRNCWVSGWGTTGDTETGLQKVNIQLIKWETCFELMPLLTKSMLCAGDLEGGKDACQGDSGGPLVCQKKTRKSKWYQLGIVSWGVGCGQKKQPGVYTQVSSYLSWIETKTKLSKRPYKHEPDSGYSLLLSPWAILVLYFLMFLLSP", "length": 311, "header": "tr|F1N4G1-1|F1N4G1_BOVIN Isoform 1 of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN=LOC112447768 PE=4 SV=4 CANONICAL=F1N4G1-1" }, "locus": { "chromosome": "8", "start_pos": 8783744, "end_pos": 8776093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055920.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055920.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052855.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052855.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "F1N4G1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "F1N4G1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4G1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "F1N4G1", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4G1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4G1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4G1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4G1" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 276, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4G9-1", "uniprot_ac": "F1N4G9", "uniprot_id": "F1N4G9_BOVIN", "mass": { "chemical_mass": 59540.0, "monoisotopic_mass": 59540.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Kinesin-like protein", "type": "recommended", "evidence": [ { "id": "F1N4G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4G9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9#function" }, { "database": "UniProtKB", "id": "ARBA00055376", "url": "https://www.uniprot.org/uniprotkb/ARBA00055376#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1N4G9", "locus": {} } ], "crossref": [ { "id": "F1N4G9", "url": "https://alphafold.ebi.ac.uk/entry/F1N4G9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038978", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038978", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01370", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01370", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VIAHKMG", "url": "https://omabrowser.org/oma/group/VIAHKMG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR47968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47968:SF69", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47968:SF69", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4G9-1", "url": "https://www.uniprot.org/uniprotkb/F1N4G9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSPQVALRIRPLNDTELEEGAAVIAHKVGDQMVVLMDPSEDPEDPLRTHRSREKTFIFDAVFDQHASQEDVYLATTQQLVEGVVSGYNATVFAYGPSGTGKTHTMLGMDTEPGIYLQTLSDLFQAIEETRDSTDCSVSMSYLEIYNEVIRDLLSPSSGFLDLREDSRGSIQIAGITEVATSNAQEIMQLLTKGNRQRTQEPTATNKTSSRSHAVLQVIVRRRGRGAHPAEEVRVGRLFMVDLAGSERASQTQNQGKRMKEGAHINRSLLALGNCINALSEKGGSRAQYVNFRDSKLTRLLKDALGGNSRTMMIAHISPASTHFEESRTTLLYAYRAKNIKTRVKRNLLSVSYHITQYTDVISDLRGQIQCLKAKVERQERERRGEPGGRDAQATIPASDAEEDSRLQMNRIRAQLIGAFQEQLEMRRSLVELENTSIELHMDTSRHLLTIADWEREKTHHLAHRAGTPERDEEALEAGPEGGEGEPAEPHEVALAREEVNMLLAEQRKTAALKVREGRCVHALSPVLRVANAL", "length": 535, "header": "tr|F1N4G9-1|F1N4G9_BOVIN Isoform 1 of Kinesin-like protein OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1N4G9-1" }, "isoforms": [ { "isoform_ac": "F1N4G9-1", "url": "https://www.uniprot.org/uniprotkb/F1N4G9/entry", "sequence": { "sequence": "MASSPQVALRIRPLNDTELEEGAAVIAHKVGDQMVVLMDPSEDPEDPLRTHRSREKTFIFDAVFDQHASQEDVYLATTQQLVEGVVSGYNATVFAYGPSGTGKTHTMLGMDTEPGIYLQTLSDLFQAIEETRDSTDCSVSMSYLEIYNEVIRDLLSPSSGFLDLREDSRGSIQIAGITEVATSNAQEIMQLLTKGNRQRTQEPTATNKTSSRSHAVLQVIVRRRGRGAHPAEEVRVGRLFMVDLAGSERASQTQNQGKRMKEGAHINRSLLALGNCINALSEKGGSRAQYVNFRDSKLTRLLKDALGGNSRTMMIAHISPASTHFEESRTTLLYAYRAKNIKTRVKRNLLSVSYHITQYTDVISDLRGQIQCLKAKVERQERERRGEPGGRDAQATIPASDAEEDSRLQMNRIRAQLIGAFQEQLEMRRSLVELENTSIELHMDTSRHLLTIADWEREKTHHLAHRAGTPERDEEALEAGPEGGEGEPAEPHEVALAREEVNMLLAEQRKTAALKVREGRCVHALSPVLRVANAL", "length": 535, "header": "tr|F1N4G9-1|F1N4G9_BOVIN Isoform 1 of Kinesin-like protein OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1N4G9-1" }, "locus": { "chromosome": "25", "start_pos": 40883682, "end_pos": 40868424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053435.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053435.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052845.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052845.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BQR5-1", "protein_name": "Kinesin-like protein", "gene_name": "LOC110259833", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPKDQPLTVALRIRPLNDAELEEGATVIAHKMGDQMVVLMDPDEDPEDPLRTQRSREKTFIFDTVFDQQASQEDVYLATTQHLVEGVISGYNATVFAYGPSGTGKTHTMLGMDAEPGIYLRTLSDLFQAIEETRGHADCSVSISYLEIYNEVIRDLLNPASGFLDLREDARGTIQIAGITEVSTSNAQEIMQLLTKGNRQRTQEPTATNKTSSRSHAVLQVTVRQRSRGTDLAEEVHVGRLFMVDLAGSERASQTQNRGKRMKEGAHINRSLLALGNCINALSEKGGSRAQYVNFRDSKLTRLLKDALGGNSRTVMVAHISPASTHFEESRTTLLYAYRAKNIKTRVKRNLLNVSYRIAQYTHVISDLRGEIERLKSKLEQQEKEKRREPGVRGAQGRAGHTAGATSLGRPGRPAPLGPP", "length": 421 }, "evidence": [ { "id": "F1N4G9", "url": "https://omabrowser.org/oma/group/F1N4G9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "F1N4G9", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4G9" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 341, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4H1-1", "uniprot_ac": "F1N4H1", "uniprot_id": "F1N4H1_BOVIN", "mass": { "chemical_mass": 24535.0, "monoisotopic_mass": 24535.0 }, "refseq": {}, "gene_names": [ { "name": "CLEC4D", "type": "recommended", "evidence": [ { "id": "F1N4H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ] } ], "protein_names": [ { "name": "C-type lectin domain family 4 member D", "type": "synonym", "evidence": [ { "id": "F1N4H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4H1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC4D", "url": "https://www.uniprot.org/uniprotkb/F1N4H1", "locus": { "chromosome": "5", "start_pos": 101693920, "end_pos": 101685184, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039347", "url": "https://www.ensembl.org/id/ENSBTAG00000039347" } ] } } ], "crossref": [ { "id": "F1N4H1", "url": "https://alphafold.ebi.ac.uk/entry/F1N4H1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039347", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039347", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4H1", "url": "https://www.orthodb.org/?gene=F1N4H1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5621480", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5621480", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4H1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQEEPLNKCEGQHSQLIPWTIAIFFMSLLSACFIANYVVTHHNFLSCKKGTGFFRLPKQHPKVICVREKPELKGGTWNCCPVGWRAFQSNCYFPFNDNKTWAQSESHCSGMGGHLATISTGAEQNFITQFLDRRFSYFLGLRSENLDGQWHWVDKKPFNPQIVFWHKREPNNDQKEKCVVLVNDKDKWAWSDFPCDSKTSWICKITGTAFN", "length": 212, "header": "tr|F1N4H1-1|F1N4H1_BOVIN Isoform 1 of C-type lectin domain family 4 member D OS=Bos taurus OX=9913 GN=CLEC4D PE=4 SV=3 CANONICAL=F1N4H1-1" }, "isoforms": [ { "isoform_ac": "F1N4H1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1/entry", "sequence": { "sequence": "MGQEEPLNKCEGQHSQLIPWTIAIFFMSLLSACFIANYVVTHHNFLSCKKGTGFFRLPKQHPKVICVREKPELKGGTWNCCPVGWRAFQSNCYFPFNDNKTWAQSESHCSGMGGHLATISTGAEQNFITQFLDRRFSYFLGLRSENLDGQWHWVDKKPFNPQIVFWHKREPNNDQKEKCVVLVNDKDKWAWSDFPCDSKTSWICKITGTAFN", "length": 212, "header": "tr|F1N4H1-1|F1N4H1_BOVIN Isoform 1 of C-type lectin domain family 4 member D OS=Bos taurus OX=9913 GN=CLEC4D PE=4 SV=3 CANONICAL=F1N4H1-1" }, "locus": { "chromosome": "5", "start_pos": 101693396, "end_pos": 101685408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055016.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055016.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052843.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052843.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5621480", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5621480", "resource": "Reactome", "description": "Dectin-2 family" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "immunoglobulin receptor binding", "id": "GO:0034987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034987", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "D-mannose binding", "id": "GO:0005537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005537", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "positive regulation of myeloid dendritic cell activation", "id": "GO:0030887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030887", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" }, { "name": "antifungal innate immune response", "id": "GO:0061760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061760", "evidence": [ { "database": "UniProtKB", "id": "F1N4H1", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4H1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 212, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4H1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4H1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4H1" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 205, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4I4-1", "uniprot_ac": "F1N4I4", "uniprot_id": "F1N4I4_BOVIN", "mass": { "chemical_mass": 142239.0, "monoisotopic_mass": 142239.0 }, "refseq": {}, "gene_names": [ { "name": "PER2", "type": "recommended", "evidence": [ { "id": "F1N4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ] } ], "protein_names": [ { "name": "Period circadian protein homolog 2", "type": "recommended", "evidence": [ { "id": "F1N4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I4/entry#names_and_taxonomy" } ] }, { "name": "Circadian clock protein PERIOD 2", "type": "synonym", "evidence": [ { "id": "F1N4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PER2", "url": "https://www.uniprot.org/uniprotkb/F1N4I4", "locus": { "chromosome": "3", "start_pos": 117558077, "end_pos": 117599996, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001879", "url": "https://www.ensembl.org/id/ENSBTAG00000001879" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001879", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001879", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512237", "url": "https://www.ncbi.nlm.nih.gov/gene/512237", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048814", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048814", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512237", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512237", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ENCSMGR", "url": "https://omabrowser.org/oma/group/ENCSMGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4I4", "url": "https://www.orthodb.org/?gene=F1N4I4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N0M5", "url": "https://www.orthodb.org/?gene=G3N0M5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11269:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11269:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08447", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08447", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21353", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21353", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9932298", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4I4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4I4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0M5", "url": "https://www.uniprot.org/uniprotkb/G3N0M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0M5-1", "url": "https://www.uniprot.org/uniprotkb/G3N0M5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCVLCKESDGRCGQWTHSTPRPRPPSMQMRRHRRQWRALGAGAESGHVFHYVTAASPRRRRRRREALPNTRCFRPQRRRGRRAARGSSSGLVRTRLRPETFGLMMAKSEHHLSTSGCSSEQSTKADAHKELIKTLKELKVHLPADRKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSENHPCRTHVPSYTVHEIEGITSEFIMKNVDMFVAAVSLVTGKTLYISDQVASIFHCKRDAFYNAKFVEFLAPHDVSVFHSSTTPYKLPPWSDRRQADSFTQECMEEKSFFCRVSVGKSHESEIHYHPFRMTPYLAQVCERQGAESQLCCVLLAERVHSGYEAPRIPPEKRIFTTTHSPNCLFQDVDQRAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKIVQSGGQPFDYSPLRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHRVRLGPLNEDVFSAPPGLEEKAPQPGVQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSTGQEDPRRRRAETCKNGNKAKSKSHYPDESGEQKSNPASEMQSGSPTPMKAAAAVEKDSSGASLPEATPPEELACRDPPAGSYQQISCLDSVIRYLESCSEAATLKRKCEFPASLPTPQASDKRQALAGPGPHATEAASPSPVKSRTDASARLLSPPLPGRAQSVASLGSQCSYSSTIVHVGDKKLPPELEPLGDAAASRPESLECPAGPALPCGLSQDQEAFRKLGLTKEVLAAHTQKEEQSFLLRFREIRKLHVFQSRCHHYLQERSKGHLSNRTAPGLRNTPGIDSSWKKNGKNRKLKSKRVKPRDSSGSTGSGGPAPQRPPLVGLNTTAWSLSDTSQSSCPAMPFPGPVPAYSLPLFPAPGIVTAPGTVATGSGAAHTDLAVPVDAQQVLRVHPPPFASPLAPVMALVLPSCSFSPVTPALPPAFFPGQLNFVSEMPPASQPEFFPDRTSTPKQPCPCAPAERGPPALRMATPGTPPLAAGPPDRTSPALFQSRGSSPLQLNLMQLEEAPEGTAAATGAVGTVGAGADCKPGSSWDWQPKSPPTCKEPADAPNSDALSSSSGLLRLLLHGDLCSATGSALSRSQASATSCSLGSGSLGCDASGSRPGSSHTSHTSRYFGSSDSSENNPGAAVRAAVGGPERLLRCVLQDPVWLLAADTDDSVRMTYQMPARDLDTVLQEDREKLKALQRLQPRFTDAQKQELQDVHPWMRLGGMPTAIDVAGCVYCENEGEDNLCVSYEEDIPTPGLSEVTETKEEESRPPQGPETNGRCNPLPQGSSAASEVR", "length": 1311, "header": "tr|F1N4I4-1|F1N4I4_BOVIN Isoform 1 of Period circadian protein homolog 2 OS=Bos taurus OX=9913 GN=PER2 PE=4 SV=3 CANONICAL=F1N4I4-1" }, "isoforms": [ { "isoform_ac": "F1N4I4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4I4/entry", "sequence": { "sequence": "MCVLCKESDGRCGQWTHSTPRPRPPSMQMRRHRRQWRALGAGAESGHVFHYVTAASPRRRRRRREALPNTRCFRPQRRRGRRAARGSSSGLVRTRLRPETFGLMMAKSEHHLSTSGCSSEQSTKADAHKELIKTLKELKVHLPADRKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSENHPCRTHVPSYTVHEIEGITSEFIMKNVDMFVAAVSLVTGKTLYISDQVASIFHCKRDAFYNAKFVEFLAPHDVSVFHSSTTPYKLPPWSDRRQADSFTQECMEEKSFFCRVSVGKSHESEIHYHPFRMTPYLAQVCERQGAESQLCCVLLAERVHSGYEAPRIPPEKRIFTTTHSPNCLFQDVDQRAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKIVQSGGQPFDYSPLRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHRVRLGPLNEDVFSAPPGLEEKAPQPGVQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSTGQEDPRRRRAETCKNGNKAKSKSHYPDESGEQKSNPASEMQSGSPTPMKAAAAVEKDSSGASLPEATPPEELACRDPPAGSYQQISCLDSVIRYLESCSEAATLKRKCEFPASLPTPQASDKRQALAGPGPHATEAASPSPVKSRTDASARLLSPPLPGRAQSVASLGSQCSYSSTIVHVGDKKLPPELEPLGDAAASRPESLECPAGPALPCGLSQDQEAFRKLGLTKEVLAAHTQKEEQSFLLRFREIRKLHVFQSRCHHYLQERSKGHLSNRTAPGLRNTPGIDSSWKKNGKNRKLKSKRVKPRDSSGSTGSGGPAPQRPPLVGLNTTAWSLSDTSQSSCPAMPFPGPVPAYSLPLFPAPGIVTAPGTVATGSGAAHTDLAVPVDAQQVLRVHPPPFASPLAPVMALVLPSCSFSPVTPALPPAFFPGQLNFVSEMPPASQPEFFPDRTSTPKQPCPCAPAERGPPALRMATPGTPPLAAGPPDRTSPALFQSRGSSPLQLNLMQLEEAPEGTAAATGAVGTVGAGADCKPGSSWDWQPKSPPTCKEPADAPNSDALSSSSGLLRLLLHGDLCSATGSALSRSQASATSCSLGSGSLGCDASGSRPGSSHTSHTSRYFGSSDSSENNPGAAVRAAVGGPERLLRCVLQDPVWLLAADTDDSVRMTYQMPARDLDTVLQEDREKLKALQRLQPRFTDAQKQELQDVHPWMRLGGMPTAIDVAGCVYCENEGEDNLCVSYEEDIPTPGLSEVTETKEEESRPPQGPETNGRCNPLPQGSSAASEVR", "length": 1311, "header": "tr|F1N4I4-1|F1N4I4_BOVIN Isoform 1 of Period circadian protein homolog 2 OS=Bos taurus OX=9913 GN=PER2 PE=4 SV=3 CANONICAL=F1N4I4-1" }, "locus": { "chromosome": "3", "start_pos": 117599797, "end_pos": 117559081, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002448.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002448.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002448.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002448.6" } ] } }, { "isoform_ac": "G3N0M5-1", "url": "https://www.uniprot.org/uniprotkb/G3N0M5/entry", "sequence": { "sequence": "MDGCADHTPSPSAPSKEPAEPWASQAALQEDVDMSGGSSGNETSENGSTGRDSQGSDCGDSGRELGLLVGPPGSLQGPETFGLMMAKSEHHLSTSGCSSEQSTKADAHKELIKTLKELKVHLPADRKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSENHPCRTHVPSYTVHEIEGITSEFIMKNVDMFVAAVSLVTGKTLYISDQVASIFHCKRDAFYNAKFVEFLAPHDVSVFHSSTTPYKLPPWSDRRQADSFTQECMEEKSFFCRVSVGKSHESEIHYHPFRMTPYLAQVCERQGAESQLCCVLLAERVHSGYEAPRIPPEKRIFTTTHSPNCLFQDVDQRAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKIVQSGGQPFDYSPLRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHRVRLGPLNEDVFSAPPGLEEKAPQPGVQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSTGQEDPRRRRAETCKNGNKAKSKSHYPDESGEQKSNPASEMQSGSPTPMKAAAAVEKDSSGASLPEATPPEELACRDPPAGSYQQISCLDSVIRYLESCSEAATLKRKCEFPASLPTPQASDKRQALAGPGPHATEAASPSPVKSRTDASARLLSPPLPGRAQSVASLGSQCSYSSTIVHVGDKKLPPELEPLGDAAASRPESLECPAGPALPCGLSQDQEAFRKLGLTKEVLAAHTQKEEQSFLLRFREIRKLHVFQSRCHHYLQERSKGHLSNRTAPGLRNTPGIDSSWKKNGKNRKLKSKRVKPRDSSGSTGSGGPAPQRPPLVGLNTTAWSLSDTSQSSCPAMPFPGPVPAYSLPLFPAPGIVTAPGTVATGSGAAHTDLAVPVDAQQVLRVHPPPFASPLAPVMALVLPSCSFSPVTPALPPAFFPGQLNFVSEMPPASQPEFFPDRTSTPKQPCPCAPAERGPPALRMATPGTPPLAAGPPDRTSPALFQSRGSSPLQLNLMQLEEAPEGTAAATGAVGTVGAGADCKPGSSWDWQPKSPPTCKEPADAPNSDALSSSSGLLRLLLHGDLCSATGSALSRSQASATSCSLGSGSLGCDASGSRPGSSHTSHTSRYFGSSDSSENNPGAAVRAAVGGPERLLRCVLQDPVWLLAADTDDSVRMTYQMPARDLDTVLQEDREKLKALQRLQPRFTDAQKQELQDVHPWMRLGGMPTAIDVAGCVYCENEGEDNLCVSYEEDIPTPGLSEVTETKEEESRPPQGPETNGRCNPLPQGSSAASEVR", "length": 1291, "header": "tr|G3N0M5-1|F1N4I4_BOVIN Computationally mapped isoform of Period circadian protein homolog 2 OS=Bos taurus OX=9913 GN=PER2 PE=4 SV=2 CANONICAL=F1N4I4-1" }, "locus": { "chromosome": "3", "start_pos": 117589984, "end_pos": 117559081, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063277.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063277.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055391.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055391.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 53, "start_aa": "Thr", "end_pos": 53, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr53", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 945, "start_aa": "Thr", "end_pos": 945, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr945", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512237", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512237", "resource": "KEGG Pathway" }, { "id": "R-BTA-9932298", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "resource": "Reactome", "description": "Degradation of CRY and PER proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A5X2-1", "protein_name": "Period circadian protein homolog 2", "gene_name": "PER2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDCIEVRGFYSSTEEQNPEQQADISENISSLFSLKEQQKMSEYSGLASNHSQMIAEDSEIQPKPEHSPEVLQEDMEMSSGSSGNDFSGNETNENYSSGHDSHGHESDENGKDSAMLMESSDCHKSSSSNAFSLMIANSEHNQSSSGCSSEQSTKAKTQKELLKTLQELKAHLPAEKRIKGKSSVLTTLKYALKSIKQVKANEEYYQLLMINESQPSGLNVSSYTVEEVETITSEYIMKNADMFAVAVSLITGKIVYISDQAAAILRCKRSYFKNAKFVELLAPQDVSVFYTSTTPYRLPSWNICSRAESSTQDCMEEKSFFCRISAGKERENEICYHPFRMTPYLIKVQDPEVAEDQLCCVLLAEKVHSGYEAPRIPPDKRIFTTTHTPTCLFQDVDERAVPLLGYLPQDLIGTPVLVHLHPNDRPLMLAIHKKILQYGGQPFDYSPIRFCTRNGDYITMDTSWSSFINPWSRKVSFIIGRHKVRTGPLNEDVFAAPNYTEDRILHPSVQEITEQIYRLLLQPVHNSGSSGYGSLGSNGSHEHLMSVASSSDSTGNNNDDTQKDKTISQDARKVKTKGQHIFTENKGKLEYKREPSAAEKQNGPGGQVKDVIGKDTTATAAPKNVATEELAWKEQPVYSYQQISCLDSVIRYLESCNVPGTAKRKCEPSSSVNSSVHEQKASVNAIQPLGDSTVLKSSGKSSGPPVVGAHLTSLALPGKPESVVSLTSQCSYSSTIVHVGDKKPQPELEMIEDGPSGAEVLDTQLPAPPPSSTHVNQEKESFKKLGLTKEVLAVHTQKEEQSFLNKFKEIKRFNIFQSHCNYYLQDKPKGRPGERGGRGQRNGTSGMDQPWKKSGKNRKSKRIKPQESSDSTTSGTKFPHRFPLQGLNTTAWSPSDTSQASYSAMSFPTVMPAYPLPVFPAAAGTVPPAPETSVSGFNQLPDSGNTCSMQPSQFSAPLMTPVVALVLPNYVYPEMNNSLPQTLYHSQANFPTHPAFSSQTVFPAQPPFTTPSPFPQQAFFPTQPFHYNPPAEIEKVPVTETRNEPSRSCTPQSVGPQDQASPPLFQSRCSSPLNLLQLEENTKTVESGAPAGLHGALNEEGTIGKIMTTDAGSGKGSLPAESPMDAQNSDALSMSSVLLDILLQEDACSGTGSASSGSGVSAAAESLGSGSNGCDMSGSRTGSSETSHTSKYFGSIDSSENHHKTKMKAEIEESEHFIKYVLQDPIWLLMANTDDTVMMTYQLPSRDLETVLKEDKLKLKQMQKLQPKFTEDQKRELIEVHPWIQQGGLPKTVANSECIFCEDNIQSNFYTSYDEEIHEMDLNEMIEDSGENNLVPLSQVNEEQT", "length": 1345 }, "evidence": [ { "id": "F1N4I4", "url": "https://omabrowser.org/oma/group/F1N4I4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SIU9-1", "protein_name": "Period circadian protein homolog 2", "gene_name": "PER2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLGVLWQPSPGKDPGVGGGPLRKGQALSGSSMNGYADYAPSPGDPSKEHVEPGPRQVPLQEDVDMSGGSSGNETNENGSPGRDSQGSDCDDSGKELRTLAGPPGAHQGPDAFSLMMAKSEHNPSTSGCSSEPSTKADAHKELIKTLRELKVHLPAEKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMASEKQPCSAHVPAYTVEELESATSEFVVKNPEMFAAAVSLVTGKILYISDQVASIFHCKRDTFYDAKFVEFLAPHDVSVFHSSTSPYKLPPWSLCRGADSFTRECMEEKSFFCRVSVGKNHESEIRYHPFRMTPYLVQVRDPQGAEDQLCCVLLAERVHSGYEAPRIPPEKRIFTTTHSPNCLFQDVDERAVPLLGHLPQDLIETPVLVQLHPSDRPLMLAIHKKIVQSGGQPFDYSPIRFRARNGEYVTLDTSWSSFVNPWSRKVSFIIGRHRVRVGPLNEDVFSAQPCMEEKALQSGVQEFTEQIRRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSTGQEDPCRRRVEICKNDNKVKNESHYPGASGQQESQSAAATQSSSLAHVSTVPAAEKDSSGASLPEELACKNPPAGSYQQISCLDGVIRYLESCSEAATLKRKCEFPAHLPTPKASDKRKATASPGPHSAETASASKMNSRADVSTHLTSLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDATSGPESLDCLAGPALPCSLGQDPEPFRKLGLTKEVLAAHTQKEEQSFLLKFKEIRKLNIFQSPCHHYLQERSRAQPSERAAPGLRNPSGVDSSWKKNGKNRKLKSKRVKPRDSSGSTGSGGPVPQRPPLLGLNATAWSPSDTSQSSCPSMPFPAPVPAYSLPVFPVPGTVAAAPHAGFAVPVDTQHEFAVQPPAFAGPLAPVLALVVPSYPFSSVASNLPQTFFPGQPSFPSQVTPASQSEFPGQTSFPKQPHACPRAEHGPPASRVATPATLPSAAGPAGRTSPPLFQSRGSSPLQLNLLQLEETPEGSASATGAAGAGPDCKPGSAWDRQPKALTTGEEPADAQNSDALSASSGLLHLLLHADVCSAAGSALSGSGASATSCSLGSGSQGCDASPSGTGSSDTGHSSKYFGSIDSSEKNHKAKVKADRAENERFIKSVLQEPVWLLAADSDDRVMMTYQMPARNVDTVLREDREKLRALRGLQPRFTDGQRQELQDVHPWMRSGGLPAALDVPECVYCGNEGKGGIGVPSEEHLPAPGLSEVADTKEEGSGPPLSHRNREQT", "length": 1290 }, "evidence": [ { "id": "F1N4I4", "url": "https://omabrowser.org/oma/group/F1N4I4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15055-1", "protein_name": "Period circadian protein homolog 2", "gene_name": "PER2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKSVTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKAESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPFKKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRNTSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSSCPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPLAPVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPCACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGADCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSGSLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLMADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLPAAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT", "length": 1255 }, "evidence": [ { "id": "F1N4I4", "url": "https://omabrowser.org/oma/group/F1N4I4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O54943-1", "protein_name": "Period circadian protein homolog 2", "gene_name": "Per2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGYVDFSPSPTSPTKEPGAPQPTQAVLQEDVDMSSGSSGNENCSTGRDSQGSDCDDNGKELRMLVESSNTHPSPDDAFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYSMEQVEGITSEYIVKNADMFAVAVSLVSGKILYISNQVASIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVCSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVKVQEQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQAVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQAGGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAPPCPEEKTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHRRRSGIFKTSGKIQTKSHVSHESGGQKEASVAEMQSSPPAQVKAVTTIERDSSGASLPKASFPEELAYKNQPPCSYQQISCLDSVIRYLESCSEAATLKRKCEFPANIPSRKATVSPGLHSGEAARPSKVTSHTEVSAHLSSLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDMASGPESLDGAAGGLSQEKGPLQKLGLTKEVLAAHTQKEEQGFLQRFREVSRLSALQAHCQNYLQERSRAQASDRGLRNTSGLESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLMGLNATAWSPSDTSQSSCPSAPFPTAVPAYPLPVFQAPGIVSTPGTVVAPPAATHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFLPSQPHFPAHPTLASEITPASQAEFPSRTSTLRQPCACPVTPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPEGSTGAAGTLGTTGTAASGLDCTSGTSRDRQPKAPPTCNEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGFGTSQSGAGSSDTSHTSKYFGSIDSSENNHKAKMIPDTEESEQFIKYVLQDPIWLLMANTDDSIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPRFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNICLPYEEDSPSPGLCDTSEAKEEEGEQLTGPRIEAQT", "length": 1257 }, "evidence": [ { "id": "F1N4I4", "url": "https://omabrowser.org/oma/group/F1N4I4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Z301-1", "protein_name": "Period circadian protein homolog 2", "gene_name": "Per2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNGYVDFSPSPTSPTQEPGEPQPTQAVLQEDVDMSSGSSGNENCSTGRDSQGSDCDDSGKELRMLVESSNTHPSPDDTFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLRELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYTMEQVEGITSEYIVKNSDMFAVAVSLVSGKILYISNQVAPIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVSSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVKVQEQKGAASQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQASGQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAASPCPEEKTPHPSVQELTEQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHWRRSGIFKTSGKSQSKSHFSPESGGQKEASVAEMQSSPPAQVRSVTTMERDSSGASLPKASFPEELTYKSQPPCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANIPSRKATVSPGLHSGEAARSSKVTSHTEVSAHLSSLALPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDVASGPESQDDAAGGLSQEKGSLQKLGLTKEVLAAHTQREEQGFLQRFREVSRLGALQAHCQNYLQERSRAPASDRGLRNASGIESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLVGLNATAWSPSDTSQSSCPSAPFPAPVPAYPLPVFPAPGIVSTPGTVVAPPAAAHTGFTMPVVPMGTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFFPSQPHFPAHPTLASEITPASQAEFPSRTSMLRQPCACPVTPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPESSTGAAGTLGTTGTAASGLDCTSGASRDRQPKAPPTCSEPSDTQNSDAISTSSDLLNLLLGEDLCSATGSALSRSGASATSDSLGSSSLGCDTSRSGAGSSDTSHTSKYFGSIDSSENNHKAKMITDTEESEQFIKYVLQDPIWLLMANTDDNIMMTYQLPSRDLQAVLKEDQEKLKLLQRSQPHFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNLCLPYEEDSPSLGLCDTSEAKEEESGQLANPRKEAQT", "length": 1257 }, "evidence": [ { "id": "F1N4I4", "url": "https://omabrowser.org/oma/group/F1N4I4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "circadian regulation of gene expression", "id": "GO:0032922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032922", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "entrainment of circadian clock by photoperiod", "id": "GO:0043153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043153", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" }, { "name": "transcription corepressor binding", "id": "GO:0001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "evidence": [ { "database": "UniProtKB", "id": "F1N4I4", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 798, "end_pos": 800, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I4" }, { "id": "PS50112", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50112" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PAS", "eco_id": "ECO_0000259", "start_pos": 366, "end_pos": 409, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 53, 945 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 508, "end_pos": 510 }, { "start_pos": 798, "end_pos": 800 }, { "start_pos": 853, "end_pos": 855 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4J1-1", "uniprot_ac": "F1N4J1", "uniprot_id": "F1N4J1_BOVIN", "mass": { "chemical_mass": 28557.0, "monoisotopic_mass": 28557.0 }, "refseq": { "ac": "XP_010807337", "name": "neural retina-specific leucine zipper protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807337" }, "gene_names": [ { "name": "NRL", "type": "recommended", "evidence": [ { "id": "F1N4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ] }, { "name": "NRL", "type": "synonym", "evidence": [ { "id": "XP_010807337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807337" } ] } ], "protein_names": [ { "name": "Neural retina-specific leucine zipper protein", "type": "recommended", "evidence": [ { "id": "F1N4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J1/entry#names_and_taxonomy" } ] }, { "name": "neural retina-specific leucine zipper protein", "type": "synonym", "evidence": [ { "id": "XP_010807337", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807337" } ] } ], "function": [ { "annotation": "Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner.", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1#function" }, { "database": "UniProtKB", "id": "ARBA00055281", "url": "https://www.uniprot.org/uniprotkb/ARBA00055281#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NRL", "url": "https://www.uniprot.org/uniprotkb/F1N4J1", "locus": { "chromosome": "10", "start_pos": 21060433, "end_pos": 21055767, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001871", "url": "https://www.ensembl.org/id/ENSBTAG00000001871" } ] } } ], "crossref": [ { "id": "F1N4J1", "url": "https://alphafold.ebi.ac.uk/entry/F1N4J1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001871", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001871", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14718", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14718", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521544", "url": "https://www.ncbi.nlm.nih.gov/gene/521544", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013592", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013592", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521544", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521544", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SGDHAHF", "url": "https://omabrowser.org/oma/group/SGDHAHF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4J1", "url": "https://www.orthodb.org/?gene=F1N4J1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10129:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10129:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03131", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03131", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010807337", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807337", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4J1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALPPSPLAMEYVNDFDLMKFEVKREPSEGRSGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEVLGLSPEEAVELLQGQSPVPVEGSHAYYPGSPEETGAQHAQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLATQLDALRAEVARLARERDLYKARCELLAPSGLGPEATPTSSSEPLATEWWSRWAGGAHHPGGACTIH", "length": 262, "header": "tr|F1N4J1-1|F1N4J1_BOVIN Isoform 1 of Neural retina-specific leucine zipper protein OS=Bos taurus OX=9913 GN=NRL PE=3 SV=3 CANONICAL=F1N4J1-1" }, "isoforms": [ { "isoform_ac": "F1N4J1-1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1/entry", "sequence": { "sequence": "MALPPSPLAMEYVNDFDLMKFEVKREPSEGRSGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEVLGLSPEEAVELLQGQSPVPVEGSHAYYPGSPEETGAQHAQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLATQLDALRAEVARLARERDLYKARCELLAPSGLGPEATPTSSSEPLATEWWSRWAGGAHHPGGACTIH", "length": 262, "header": "tr|F1N4J1-1|F1N4J1_BOVIN Isoform 1 of Neural retina-specific leucine zipper protein OS=Bos taurus OX=9913 GN=NRL PE=3 SV=3 CANONICAL=F1N4J1-1" }, "locus": { "chromosome": "10", "start_pos": 21059429, "end_pos": 21057749, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002437.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002437.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002437.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002437.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 232, "start_aa": "Thr", "end_pos": 232, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr232", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521544", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521544", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ACF4-1", "protein_name": "Neural retina-specific leucine zipper protein", "gene_name": "Nrl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQSQGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL", "length": 238 }, "evidence": [ { "id": "F1N4J1", "url": "https://omabrowser.org/oma/group/F1N4J1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P54845-1", "protein_name": "Neural retina-specific leucine zipper protein", "gene_name": "NRL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALPPSPLAMEYVNDFDLMKFEVKREPSEGRPGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEALGLSPEEAMELLQGQGPVPVDGPHGYYPGSPEETGAQHVQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSSGPGSGDPSHLFL", "length": 237 }, "evidence": [ { "id": "F1N4J1", "url": "https://omabrowser.org/oma/group/F1N4J1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P54846-1", "protein_name": "Neural retina-specific leucine zipper protein", "gene_name": "Nrl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGGGEAPRPGLEELYWLATLQQQLGSDEVLGLSPDEAVELLQNQGPVSMEGPLGYYSGSPGETGAQHVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL", "length": 237 }, "evidence": [ { "id": "F1N4J1", "url": "https://omabrowser.org/oma/group/F1N4J1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "retinal rod cell development", "id": "GO:0046548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046548", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "leucine zipper domain binding", "id": "GO:0043522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043522", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "F1N4J1", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4J1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 262, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4J1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4J1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J1" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 222, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 232 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4J8-1", "uniprot_ac": "F1N4J8", "uniprot_id": "F1N4J8_BOVIN", "mass": { "chemical_mass": 11623.0, "monoisotopic_mass": 11623.0 }, "refseq": { "ac": "NP_001179595", "name": "protein S100-Z", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179595" }, "gene_names": [ { "name": "S100Z", "type": "recommended", "evidence": [ { "id": "F1N4J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J8" } ] }, { "name": "S100Z", "type": "synonym", "evidence": [ { "id": "NP_001179595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179595" } ] } ], "protein_names": [ { "name": "Protein S100", "type": "recommended", "evidence": [ { "id": "F1N4J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J8/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein", "type": "synonym", "evidence": [ { "id": "F1N4J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J8/entry#names_and_taxonomy" } ] }, { "name": "protein S100-Z", "type": "synonym", "evidence": [ { "id": "NP_001179595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179595" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4J8", "url": "https://www.uniprot.org/uniprotkb/F1N4J8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100Z", "url": "https://www.uniprot.org/uniprotkb/F1N4J8", "locus": { "chromosome": "10", "start_pos": 8062233, "end_pos": 8059122, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020201", "url": "https://www.ensembl.org/id/ENSBTAG00000020201" } ] } } ], "crossref": [ { "id": "F1N4J8", "url": "https://alphafold.ebi.ac.uk/entry/F1N4J8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020201", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020201", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528723", "url": "https://www.ncbi.nlm.nih.gov/gene/528723", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528723", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528723", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N4J8", "url": "https://www.orthodb.org/?gene=F1N4J8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N4J8", "url": "https://www.uniprot.org/uniprotkb/F1N4J8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4J8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4J8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTQLEIAMNIMIRTFHRYSCREGDRFKLNKGELKMLLQRELTEFLSCQKDPELVDKIMQDLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK", "length": 99, "header": "tr|F1N4J8-1|F1N4J8_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100Z PE=3 SV=4 CANONICAL=F1N4J8-1" }, "isoforms": [ { "isoform_ac": "F1N4J8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4J8/entry", "sequence": { "sequence": "MPTQLEIAMNIMIRTFHRYSCREGDRFKLNKGELKMLLQRELTEFLSCQKDPELVDKIMQDLDANKDNEVDFNEFVVMVAALTVACNDYFVEQLKKKGK", "length": 99, "header": "tr|F1N4J8-1|F1N4J8_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100Z PE=3 SV=4 CANONICAL=F1N4J8-1" }, "locus": { "chromosome": "10", "start_pos": 8061865, "end_pos": 8059177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026904.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026904.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026904.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026904.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528723", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528723", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1N4J8", "url": "https://www.uniprot.org/uniprotkb/F1N4J8" } ], "pmid": "" }, { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "F1N4J8", "url": "https://www.uniprot.org/uniprotkb/F1N4J8" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1N4J8", "url": "https://www.uniprot.org/uniprotkb/F1N4J8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4J8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 99, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4J8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4J8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4J8" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 85, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4Q4-1", "uniprot_ac": "F1N4Q4", "uniprot_id": "F1N4Q4_BOVIN", "mass": { "chemical_mass": 43385.0, "monoisotopic_mass": 43385.0 }, "refseq": { "ac": "NP_001179218", "name": "polyadenylate-binding protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179218" }, "gene_names": [ { "name": "PABPC5", "type": "recommended", "evidence": [ { "id": "F1N4Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ] }, { "name": "PABPC5", "type": "synonym", "evidence": [ { "id": "NP_001179218", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179218" } ] } ], "protein_names": [ { "name": "Polyadenylate-binding protein 5", "type": "recommended", "evidence": [ { "id": "F1N4Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4/entry#names_and_taxonomy" } ] }, { "name": "polyadenylate-binding protein 5-like", "type": "synonym", "evidence": [ { "id": "NP_001179218", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179218" } ] }, { "name": "polyadenylate-binding protein 5", "type": "synonym", "evidence": [ { "id": "NP_001179218", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179218" } ] } ], "function": [ { "annotation": "Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4#function" }, { "database": "UniProtKB", "id": "ARBA00043929", "url": "https://www.uniprot.org/uniprotkb/ARBA00043929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PABPC5", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4", "locus": { "chromosome": "X", "start_pos": 39341834, "end_pos": 39337337, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019942", "url": "https://www.ensembl.org/id/ENSBTAG00000019942" } ] } } ], "crossref": [ { "id": "F1N4Q4", "url": "https://alphafold.ebi.ac.uk/entry/F1N4Q4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019942", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019942", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12378", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12378", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12379", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12379", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511286", "url": "https://www.ncbi.nlm.nih.gov/gene/511286", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006515", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006515", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511286", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511286", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTIFVFY", "url": "https://omabrowser.org/oma/group/CTIFVFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4Q4", "url": "https://www.orthodb.org/?gene=F1N4Q4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179218", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4Q4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSGEPNPAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRKSGIGNIFIKNLDKSIDNRALFYLFSAFGSILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDKATFTNVFVKNFGDDMDDDKLKELFSEYGPTESVKVIRDSSGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETIDDEKLKEEFSSFGSISRAKVMVEVGQGKGFGVICFSSFEEATKAVDEMNGRIVGSKPLQVTLGQARRRW", "length": 382, "header": "tr|F1N4Q4-1|F1N4Q4_BOVIN Isoform 1 of Polyadenylate-binding protein 5 OS=Bos taurus OX=9913 GN=PABPC5 PE=4 SV=2 CANONICAL=F1N4Q4-1" }, "isoforms": [ { "isoform_ac": "F1N4Q4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4/entry", "sequence": { "sequence": "MGSGEPNPAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRKSGIGNIFIKNLDKSIDNRALFYLFSAFGSILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDKATFTNVFVKNFGDDMDDDKLKELFSEYGPTESVKVIRDSSGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETIDDEKLKEEFSSFGSISRAKVMVEVGQGKGFGVICFSSFEEATKAVDEMNGRIVGSKPLQVTLGQARRRW", "length": 382, "header": "tr|F1N4Q4-1|F1N4Q4_BOVIN Isoform 1 of Polyadenylate-binding protein 5 OS=Bos taurus OX=9913 GN=PABPC5 PE=4 SV=2 CANONICAL=F1N4Q4-1" }, "locus": { "chromosome": "X", "start_pos": 39339483, "end_pos": 39338338, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026566.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026566.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026566.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026566.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511286", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511286", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AZY8-1", "protein_name": "Polyadenylate-binding protein 5", "gene_name": "PABPC5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSGEPNPAGKKKKYLKAALYVGDLAPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNFGEDMDDDKLKEIFSEYGPTESVKVIRDASGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETIDDEKLKEQFSSFGSITRAKVMVEVGQGKGFGVVCFSSFEEATKAVDEMNGRVVGSKPLHVTLGQARRRW", "length": 382 }, "evidence": [ { "id": "F1N4Q4", "url": "https://omabrowser.org/oma/group/F1N4Q4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A5H0-1", "protein_name": "Polyadenylate-binding protein 5", "gene_name": "Pabpc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSGEPNTAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDHLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNFGDDIDDEKLKKLFSEYGPTESVKVIRDATGKSKGFGFVRYETHEAAQKAVLELHGKSIDGKVLCVGRAQKKIERLAELRRRFERLKLKDKTRPPGVPIYIKNLDETINDEKLKEEFSLFGSISRAKVMMEVGQGKGFGVVCFSSFEEASKAVNEMNGRVVGSKTLHVTLGQAR", "length": 379 }, "evidence": [ { "id": "F1N4Q4", "url": "https://omabrowser.org/oma/group/F1N4Q4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F4HT49-1", "protein_name": "Polyadenylate-binding protein 1", "gene_name": "PAB1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTLEPDIYLKKIIREQRRVSTIRTSENKFEKHTLYIGDLDSSVEEGDLYTKFSEFTHDISSVKVCCDRNTGLSLGYGYVNFNHSSQAKTAMEVLNYCKLKGKPMRIMFSERDPSNRMSGRGNVFVKNLDESIDNKQLCDMFSAFGKVLSCKVARDASGVSKGYGFVQFYSDLSVYTACNFHNGTLIRNQHIHVCPFVSRGQWDKSRVFTNVYVKNLVETATDADLKRLFGEFGEITSAVVMKDGEGKSRRFGFVNFEKAEAAVTAIEKMNGVVVDEKELHVGRAQRKTNRTEDLKAKFELEKIIRDMKTRKGMNLYVKNLDDSVDNTKLEELFSEFGTITSCKVMVHSNGISKGVGFVEFSTSEEASKAMLKMNGKMVGNKPIYVSLAQCKEQHKLHLQTQFNNPPPSPHQQPIFSQVVAPATMLSQQTPLRGYNFQPYSMCGSRMPNSCPPISIPNFMVPQPFRPTLYPPAPLVGLYGSLPQPLLQPNLWNPYRRF", "length": 497 }, "evidence": [ { "id": "F1N4Q4", "url": "https://omabrowser.org/oma/group/F1N4Q4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q96DU9-1", "protein_name": "Polyadenylate-binding protein 5", "gene_name": "PABPC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSGEPNPAGKKKKYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTMNFDLINGKPFRLMWSQPDDRLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILSCKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRDRATFTNVFVKNIGDDIDDEKLKELFCEYGPTESVKVIRDASGKSKGFGFVRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETINDEKLKEEFSSFGSISRAKVMMEVGQGKGFGVVCFSSFEEATKAVDEMNGRIVGSKPLHVTLGQARRRC", "length": 382 }, "evidence": [ { "id": "F1N4Q4", "url": "https://omabrowser.org/oma/group/F1N4Q4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" }, { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "F1N4Q4", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4Q4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 382, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4Q4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4Q4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4Q4" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 96, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4S3-1", "uniprot_ac": "F1N4S3", "uniprot_id": "F1N4S3_BOVIN", "mass": { "chemical_mass": 67621.0, "monoisotopic_mass": 67621.0 }, "refseq": {}, "gene_names": [ { "name": "EPS8L3", "type": "recommended", "evidence": [ { "id": "F1N4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ] } ], "protein_names": [ { "name": "Epidermal growth factor receptor kinase substrate 8-like protein 3", "type": "recommended", "evidence": [ { "id": "F1N4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S3/entry#names_and_taxonomy" } ] }, { "name": "Epidermal growth factor receptor pathway substrate 8-related protein 3", "type": "synonym", "evidence": [ { "id": "F1N4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPS8L3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3", "locus": { "chromosome": "3", "start_pos": 33649761, "end_pos": 33634806, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001845", "url": "https://www.ensembl.org/id/ENSBTAG00000001845" } ] } } ], "crossref": [ { "id": "F1N4S3", "url": "https://alphafold.ebi.ac.uk/entry/F1N4S3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001845", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001845", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01210", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01210", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11764", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11764", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4S3", "url": "https://www.orthodb.org/?gene=F1N4S3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12287", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12287", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12287:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12287:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08416", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08416", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18016", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18016", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22975", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22975", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0ABI0P584", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P584", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P584-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P584-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRPSSRAIYLHRKEYLQKIALEPTHLQHRVEHLMTCKLGTQRIQEPKDALQKLQEMDAQGRVWSQDLLLQVRDGWLQLLDIETKEELESYRLDRIKVMDVALNTGSYNSVLSITVQDSDLRSTSTLLFQCQEVGAERLKTSLEKALEEEVEQSRPQLGALRPDQDRWRGSSLERPLPKEQARPLEWGPPPEQHYLMSPEHNTPPPSPRPLPHRTSIREPSIFLLSPSRRSPSPEDPKWDKEVLDHVLRDIELFVGKLDEAQSKTSRKKKNHRKKKKKNKEEITEVHYIDCFQKIKYSFNLLGRLATRLQDTSAPEFVHIIFKILDSIQTQCPESDLAARVISPLLTTKAIELLQSCLSPSENNLWEGLGTAWTTSQANWTGSEPLPYKPTFYDGWQLPETSYQALSSYQDPTSIRRESPRLRSTSHFAQEETHNHGPSPVPSRPGSVKPALKMQVLYEFEARNPQELTVVQGEVLEVLDQSKRWWLVKNAMGRSGYIPSNILEPLESGAPRSQSESPTRGPMLRLSSRPEEVTAWLQAENFSTVTVKTLGSMTGSQLLHMRPGELQMLCPQEGPRVLARLEAVRRTLGMSP", "length": 592, "header": "tr|F1N4S3-1|F1N4S3_BOVIN Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 3 OS=Bos taurus OX=9913 GN=EPS8L3 PE=3 SV=4 CANONICAL=F1N4S3-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P584-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P584/entry", "sequence": { "sequence": "MSRPSSRAIYLHRKEYLQKIALEPTHLQHRVEHLMTCKLGTQRIQEPKDALQKLQEMDAQGRVWSQDLLLQVRDGWLQLLDIETKEELESYRLDRIKVMDVALNTGSYNSVLSITVQDSDLRSTSTLLFQCQEVGAERLKTSLEKALEEEVEQRPQLGALRPPEQHYLMSPEHNTPPPSPRPLPHRTSIREPSIFLLSPSRRSPSPEDPKWDKEVLDHVLRDIELFVGKLDEAQSKTSRKKKNHRKKKKKNKEEITEVHYIDCFQKIKYSFNLLGRLATRLQDTSAPEFVHIIFKILDSIQTQCPESDLAARVISPLLTTKAIELLQSCLSPSENNLWEGLGTAWTTSQANWTGSEPLPYKPTFYDGWQLPETSYQALSSYQDPTSIRRESPRLRSTSHFAQEETHNHGPSPVPSRPGSVKPALKMQVLYEFEARNPQELTVVQGEVLEVLDQSKRWWLVKNAMGRSGYIPSNILEPLESGAPRSQSESPTRGPMLRLSSRPEEVTAWLQAENFSTVTVKTLGSMTGSQLLHMRPGELQMLCPQEGPRVLARLEAVRRTLGMSP", "length": 564, "header": "tr|A0ABI0P584-1|A0ABI0P584_BOVIN Computationally mapped isoform of Epidermal growth factor receptor kinase substrate 8-like protein 3 OS=Bos taurus OX=9913 GN=EPS8L3 PE=3 SV=1 CANONICAL=F1N4S3-1" }, "locus": { "chromosome": "3", "start_pos": 33649230, "end_pos": 33638910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151089.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151089.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106304.1" } ] } }, { "isoform_ac": "F1N4S3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S3/entry", "sequence": { "sequence": "MSRPSSRAIYLHRKEYLQKIALEPTHLQHRVEHLMTCKLGTQRIQEPKDALQKLQEMDAQGRVWSQDLLLQVRDGWLQLLDIETKEELESYRLDRIKVMDVALNTGSYNSVLSITVQDSDLRSTSTLLFQCQEVGAERLKTSLEKALEEEVEQSRPQLGALRPDQDRWRGSSLERPLPKEQARPLEWGPPPEQHYLMSPEHNTPPPSPRPLPHRTSIREPSIFLLSPSRRSPSPEDPKWDKEVLDHVLRDIELFVGKLDEAQSKTSRKKKNHRKKKKKNKEEITEVHYIDCFQKIKYSFNLLGRLATRLQDTSAPEFVHIIFKILDSIQTQCPESDLAARVISPLLTTKAIELLQSCLSPSENNLWEGLGTAWTTSQANWTGSEPLPYKPTFYDGWQLPETSYQALSSYQDPTSIRRESPRLRSTSHFAQEETHNHGPSPVPSRPGSVKPALKMQVLYEFEARNPQELTVVQGEVLEVLDQSKRWWLVKNAMGRSGYIPSNILEPLESGAPRSQSESPTRGPMLRLSSRPEEVTAWLQAENFSTVTVKTLGSMTGSQLLHMRPGELQMLCPQEGPRVLARLEAVRRTLGMSP", "length": 592, "header": "tr|F1N4S3-1|F1N4S3_BOVIN Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 3 OS=Bos taurus OX=9913 GN=EPS8L3 PE=3 SV=4 CANONICAL=F1N4S3-1" }, "locus": { "chromosome": "3", "start_pos": 33649230, "end_pos": 33638910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002409.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002409.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002409.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002409.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "Rho protein signal transduction", "id": "GO:0007266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" }, { "name": "regulation of Rho protein signal transduction", "id": "GO:0035023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" }, { "name": "regulation of hair cycle", "id": "GO:0042634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042634", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" }, { "name": "positive regulation of ruffle assembly", "id": "GO:1900029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900029", "evidence": [ { "database": "UniProtKB", "id": "F1N4S3", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4S3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 592, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4S3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4S3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S3" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 449, "end_pos": 508, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 379, "end_pos": 381 }, { "start_pos": 541, "end_pos": 543 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4S9-1", "uniprot_ac": "F1N4S9", "uniprot_id": "F1N4S9_BOVIN", "mass": { "chemical_mass": 117543.0, "monoisotopic_mass": 117543.0 }, "refseq": { "ac": "NP_001192255", "name": "beta-klotho precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192255" }, "gene_names": [ { "name": "KLB", "type": "recommended", "evidence": [ { "id": "F1N4S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ] }, { "name": "KLB", "type": "synonym", "evidence": [ { "id": "NP_001192255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192255" } ] } ], "protein_names": [ { "name": "Klotho beta", "type": "synonym", "evidence": [ { "id": "F1N4S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S9/entry#names_and_taxonomy" } ] }, { "name": "beta-klotho precursor", "type": "synonym", "evidence": [ { "id": "NP_001192255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192255" } ] } ], "function": [ { "annotation": "Constitutive Expression of TERT Enhances beta-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001192255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192255" }, { "database": "PubMed", "id": "34070219", "url": "https://glygen.org/publication/PubMed/34070219" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLB", "url": "https://www.uniprot.org/uniprotkb/F1N4S9", "locus": { "chromosome": "6", "start_pos": 58563083, "end_pos": 58528467, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014517", "url": "https://www.ensembl.org/id/ENSBTAG00000014517" } ] } } ], "crossref": [ { "id": "F1N4S9", "url": "https://alphafold.ebi.ac.uk/entry/F1N4S9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014517", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014517", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514925", "url": "https://www.ncbi.nlm.nih.gov/gene/514925", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514925", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514925", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRKFWKA", "url": "https://omabrowser.org/oma/group/RRKFWKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4S9", "url": "https://www.orthodb.org/?gene=F1N4S9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10353:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00232", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00232", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-109704", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1257604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1307965", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1307965", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654228", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654228", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654712", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654712", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654720", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654720", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5654733", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654733", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192255", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4S9-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSGGLQRSVILSAFILLRAVTGFSGDGRTIWSKNPNFSPVNESQLFLYDTFPKNFFWGVGTGAFQVEGNWKADGKGPSIWDHFIHTHLKNVNSMNSSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPGGIVSAVNAKGLQYYDTLLNALVLRNIEPIVTLYHWDLPLALQEKYGGWKNETIIDFFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGYGTGIHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNRNFRPHQKGQLSITLGSHWIEPNRSENTMDILKCQQSMVSVLGWFANPIHRDGDYPEVMRKQLFSILPRFSEAEKNEVRGTADFFAFSFGPNNFKPHNTMAKLGQNVSLNLRDVLNWIKLEYGNPRILITENGWFTDSHVKTEDTTAIYMMKNFLNQVLQAIKFDEIQVFGYTAWSLLDGFEWQDAYTTRRGLFYVDFNSKQKERKPKSSAHYYKQIIQENGFTVKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNVTGNRLLHRVEGVRLKTRPAQCTDFVSIKRQLEMLARMKVTHYRFALDWPSILPTGNLSMANRQALRYYRCVVSEGLKLNISSMVTLYYPTHAHLGLPVPLLHSGGWLNRSTAEAFQDYADLCFRELGDLVKLWITINEPNRLSDIYEQSSNDTYWAAHHLLIAHALAWHLYDRRYRPVQRGAVSLSLHSDWAEPANPYADSHWKAAERFLQFEIAWFAEPLFKTGDYPLAMREYVAFKNRQGLARSTLPQFTEEERRLVKGTADFYALNHFTTRFVMHERQNGSTYDTDRDIQFLQDITCLSSPTRLAVMPWGERRVLKWIRRNYGDMDVYITASGIDDQSLENDELRKYYLEKYIQEALKGYLIDKIKIKGYYVFKLTEEKSRPRFGFFTPDFKAKSSIQFYNKLISNNGFLSENSSPRCSQAQRNTECIVCLLLVQKKPLIFFGCCFFSTLVLLLSITIFHKRKRRKIWKAKNSQHIPLKKGHSRVLS", "length": 1016, "header": "tr|F1N4S9-1|F1N4S9_BOVIN Isoform 1 of Klotho beta OS=Bos taurus OX=9913 GN=KLB PE=3 SV=2 CANONICAL=F1N4S9-1" }, "isoforms": [ { "isoform_ac": "F1N4S9-1", "url": "https://www.uniprot.org/uniprotkb/F1N4S9/entry", "sequence": { "sequence": "MSSGGLQRSVILSAFILLRAVTGFSGDGRTIWSKNPNFSPVNESQLFLYDTFPKNFFWGVGTGAFQVEGNWKADGKGPSIWDHFIHTHLKNVNSMNSSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPGGIVSAVNAKGLQYYDTLLNALVLRNIEPIVTLYHWDLPLALQEKYGGWKNETIIDFFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGYGTGIHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNRNFRPHQKGQLSITLGSHWIEPNRSENTMDILKCQQSMVSVLGWFANPIHRDGDYPEVMRKQLFSILPRFSEAEKNEVRGTADFFAFSFGPNNFKPHNTMAKLGQNVSLNLRDVLNWIKLEYGNPRILITENGWFTDSHVKTEDTTAIYMMKNFLNQVLQAIKFDEIQVFGYTAWSLLDGFEWQDAYTTRRGLFYVDFNSKQKERKPKSSAHYYKQIIQENGFTVKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNVTGNRLLHRVEGVRLKTRPAQCTDFVSIKRQLEMLARMKVTHYRFALDWPSILPTGNLSMANRQALRYYRCVVSEGLKLNISSMVTLYYPTHAHLGLPVPLLHSGGWLNRSTAEAFQDYADLCFRELGDLVKLWITINEPNRLSDIYEQSSNDTYWAAHHLLIAHALAWHLYDRRYRPVQRGAVSLSLHSDWAEPANPYADSHWKAAERFLQFEIAWFAEPLFKTGDYPLAMREYVAFKNRQGLARSTLPQFTEEERRLVKGTADFYALNHFTTRFVMHERQNGSTYDTDRDIQFLQDITCLSSPTRLAVMPWGERRVLKWIRRNYGDMDVYITASGIDDQSLENDELRKYYLEKYIQEALKGYLIDKIKIKGYYVFKLTEEKSRPRFGFFTPDFKAKSSIQFYNKLISNNGFLSENSSPRCSQAQRNTECIVCLLLVQKKPLIFFGCCFFSTLVLLLSITIFHKRKRRKIWKAKNSQHIPLKKGHSRVLS", "length": 1016, "header": "tr|F1N4S9-1|F1N4S9_BOVIN Isoform 1 of Klotho beta OS=Bos taurus OX=9913 GN=KLB PE=3 SV=2 CANONICAL=F1N4S9-1" }, "locus": { "chromosome": "6", "start_pos": 58560535, "end_pos": 58528653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019297.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019297.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019297.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019297.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Constitutive Expression of TERT Enhances \u03b2-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos.", "journal": "International journal of molecular sciences", "date": "2021-05-18", "authors": "Xu Lianguang, Idrees Muhammad, Joo Myeong-Don, Sidrat Tabinda, Wei Yiran, Song Seok-Hwan, Lee Kyeong-Lim, Kong Il-Keun", "evidence": [ { "database": "RefSeq", "id": "NP_001192255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192255" } ], "reference": [ { "type": "PubMed", "id": "34070219", "url": "https://glygen.org/publication/PubMed/34070219" } ] } ], "pathway": [ { "id": "bta:514925", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514925", "resource": "KEGG Pathway" }, { "id": "R-BTA-109704", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "resource": "Reactome", "description": "PI3K Cascade" }, { "id": "R-BTA-1257604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-BTA-1307965", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1307965", "resource": "Reactome", "description": "betaKlotho-mediated ligand binding" }, { "id": "R-BTA-5654228", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654228", "resource": "Reactome", "description": "Phospholipase C-mediated cascade; FGFR4" }, { "id": "R-BTA-5654712", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654712", "resource": "Reactome", "description": "FRS-mediated FGFR4 signaling" }, { "id": "R-BTA-5654719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654719", "resource": "Reactome", "description": "SHC-mediated cascade:FGFR4" }, { "id": "R-BTA-5654720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654720", "resource": "Reactome", "description": "PI-3K cascade:FGFR4" }, { "id": "R-BTA-5654733", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5654733", "resource": "Reactome", "description": "Negative regulation of FGFR4 signaling" }, { "id": "R-BTA-5673001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "resource": "Reactome", "description": "RAF/MAP kinase cascade" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IX01-1", "protein_name": "Beta-klotho", "gene_name": "klb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MCFLSSVSFALLLISVCPSESLLQGDSSSVWLQRLNGTHQQTGVFPRGFLWGIGSSAFPTEGSWDADGKGASIWDHFTLQSPAGASSDSYIQWEEDLKAVQFLGVDFYSFSLSWPRLFPDLTLNPNPAGVEHYRRLIRKLKELNVEPVVTLFHWDLPQVLQERLGGWLNSSMVGVFADYAEFCFRTFGDEVRFWITMHNPFLVAVQGYGTGAHAPGVKGERGDPFIAAHNLIRAHAKAYHVYDKLFRARQNGKVSISLGSHWVEPLHGQATPTNLELCQKSMEAVIGWFAEPIYGSGDYPESLKSANRGVIPEFSAAERLWVRGSADFFSVAFGPETLRVSRGLARFGQTVALELRSVLVWVQQAYGDPLVLVAESGWFSDASVGVEDTLAIYLNKRFILQVMQAVSVDAVRVFGYTAWSLLDGYEWNQGFSVRRGLFYIDFSQSERRRVPKTSAHFYRQTVRDNGFPDTDTKHIQARFPCHFQFGVSDSILQVRLHPFSPQFTDPHLYRWNFSGDGSLKPVNGIILHTRPAQCTDFLFIQRHLFLLGVTGSTHYRFSLDWTQLSPSAGHPETLRFYRCVFSELQRRGIQPVVTLYHPSYRSSSLGLPEALHANGGWRNASTVDAFVRYATFCYREFGALVHMWITINEPNRLTDAYSGSADDRRVVARHLLLAHAKAWRAYDVYFRKQQGATVSLALHADWVEPANPFLESHKNAQQHFLLFELGRFIDPLYNQESSSSTLIGWSDDEREELRGALDFIALNHFTTRLVSPWAHLKASTPDHGCSLMNDVNWQTSQMGQALVPWGLRRMLGWVKNRYGNRLPIIITASGVDDQAAYHDQLRQSYIRDYLQEALKARELDGVNLRGFYIWKLQDHHDLQFGLFSSAAHHSRPKASASLYRDIISHRGFISSGDPCQSADEDGTSCEICAHIAENKPLLFFSVCVFVSVCMICVLIILSVLRKRRRKRRKTLSVPQRVPVPQRFPMMRVTHRLRH", "length": 994 }, "evidence": [ { "id": "F1N4S9", "url": "https://omabrowser.org/oma/group/F1N4S9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Z2L0-1", "protein_name": "Klotho beta", "gene_name": "KLB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGQQLKRFVAFWTLVVVRIVAGLAGEGRSVWKKDPNSSPVNETQMFLYDTFPTEFLWGVGTGAFQVEGSWRKDERGPSVWDRFIRTELRDAESADVSSDSYTLLDKDVSALDFLGVTFYQFSISWSRLFPTGVVAAPNEKGLQYYNTLIDSLVYRNIHPVVTLYHWDLPLTLQEQYGGWKNESVIDIFNDYATFCFQTFGDRVKYWITIHNPYLVAWHGYGTGIHAPGEKGKITTVYAVGHNLIKAHAKVWHNYKKHFQPYQKGLMSIVLGSHWIEPNRSEDALDISKCQQSVERVLGWFAKPIHGDGDYPEELKNESFLPRFTEDEKKYIKGTADFFAFSFGPDNFKPPNTLPKMGQNLSLNLREVLNWIKLEYGSPRIFIAENGWFTDSHVKTDDTTAIYMMKNFINKVLQAIKYDNIDVFGYTAWSLLDGFEWQHAYKIRRGLFYVDFKSEKKERIPKSSALYYKQIIQENGFFPRESTPSVQAQFSCDFSWGITESVLKAESVASSPQFCDPNLYLWNITGDGLLHKVEGVKLKTRPAQCTDFVSIKKQLDLLEKMKVTHYRFALDWSLILPNGDLSVVNRQVLRYYRCVISEVLKLNIQSMVTLYYPTHAYLGLPGPLLQTGGWLNRSTAYAFQDYAALCFQELGDLVKLWITINEPNRLSDVYNRSSSDTYRAAHNLLIAHAMAWRTYDEQYRSFQYGKVSLSLHSDWAEPANPYFESHAKAANRFLQFEIGWFADPIFKTGDYPATMREYIHFKNRKGLSHSSLPSFTSEERKLIKGAADFYALNHFTTRFVIHEPQNGSQYEFDRDIQFLQDITCLSSPSRLAVVPWGVRKVLKWIKRTYGDIDIYITANGIDDQSLDNDELRNYYLEKYVQEVLKAYYVDKVKVRGYYAFKLTEEKSKPRFGFFTSDSKGKPSIKFYNNLISNNGFPADYSVCDPSNEKRCSFCLFVSQKKPFIFFACCLFSTLILLLTIIVFHKRKKRKHFKAKRIQHICGSL", "length": 1004 }, "evidence": [ { "id": "F1N4S9", "url": "https://omabrowser.org/oma/group/F1N4S9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3Z8T6-1", "protein_name": "Klotho beta", "gene_name": "Klb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTGCAAGSPGNEWVFFSSDERSTRSRKTMSNGALQRSAVLSALVLLRAVTGFSGDGKAIWDKKQYVSPVNPGQLFLYDTFPKNFSWGVGTGAFQVEGSWKADGRGPSIWDRYVDSHLRGVNSTDRSTDSYVFLEKDLLALDFLGVSFYQFSISWPRLFPNGTVAAVNAKGLQYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKAHSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTENMEDVINCQHSMSSVLGWFANPIHGDGDYPEFMKTSSVIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSLNLRQVLNWIKLEYDNPRILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEIQVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPLQESTPDMKGQFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVRLKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKINRQVLRYYRCVVSEGLKLGISPMVTLYHPTHSHLGLPMPLLSSGGWLNTNTAKAFQDYAGLCFQELGDLVKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSLHSDWAEPANPYVESHWKAAERFLQFEIAWFADPLFKTGDYPLAMKEYIASKKQRGLSSSVLPRFTLKESRLVKGTIDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSSPSRLAVTPWGMRKLLGWIRRNYRDMDIYVTANGIDDLALEDDQIRKYYLEKYVQEALKAYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFKAKSSVQFYSKLISSSGFSSENRSPACGQPPEDTECAICSFLTQKKPLIFFGCCFISTLAALLSITIFHHRKRRKFQKARNLQNIPLKKGHSRVFS", "length": 1043 }, "evidence": [ { "id": "F1N4S9", "url": "https://omabrowser.org/oma/group/F1N4S9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86Z14-1", "protein_name": "Beta-klotho", "gene_name": "KLB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRVVS", "length": 1044 }, "evidence": [ { "id": "F1N4S9", "url": "https://omabrowser.org/oma/group/F1N4S9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99N32-1", "protein_name": "Beta-klotho", "gene_name": "Klb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTGCAAGSPGNEWIFFSSDERNTRSRKTMSNRALQRSAVLSAFVLLRAVTGFSGDGKAIWDKKQYVSPVNPSQLFLYDTFPKNFSWGVGTGAFQVEGSWKTDGRGPSIWDRYVYSHLRGVNGTDRSTDSYIFLEKDLLALDFLGVSFYQFSISWPRLFPNGTVAAVNAQGLRYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKAHSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTDNMEDVINCQHSMSSVLGWFANPIHGDGDYPEFMKTGAMIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSLNLRQVLNWIKLEYDDPQILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEIRVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPLKESTPDMKGRFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVRLKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKVNRQVLRYYRCVVSEGLKLGVFPMVTLYHPTHSHLGLPLPLLSSGGWLNMNTAKAFQDYAELCFRELGDLVKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSLHCDWAEPANPFVDSHWKAAERFLQFEIAWFADPLFKTGDYPSVMKEYIASKNQRGLSSSVLPRFTAKESRLVKGTVDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSSPSRLAVTPWGVRKLLAWIRRNYRDRDIYITANGIDDLALEDDQIRKYYLEKYVQEALKAYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFRAKSSVQFYSKLISSSGLPAENRSPACGQPAEDTDCTICSFLVEKKPLIFFGCCFISTLAVLLSITVFHHQKRRKFQKARNLQNIPLKKGHSRVFS", "length": 1043 }, "evidence": [ { "id": "F1N4S9", "url": "https://omabrowser.org/oma/group/F1N4S9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity, hydrolyzing O-glycosyl compounds", "id": "GO:0004553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004553", "evidence": [ { "database": "UniProtKB", "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ], "pmid": "" }, { "name": "fibroblast growth factor binding", "id": "GO:0017134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017134", "evidence": [ { "database": "UniProtKB", "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor binding", "id": "GO:0005104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005104", "evidence": [ { "database": "UniProtKB", "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F1N4S9", "url": "https://www.uniprot.org/uniprotkb/F1N4S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 582, "end_pos": 584, "annotation": "n_glycosylation_sequon" }, { "start_pos": 605, "end_pos": 607, "annotation": "n_glycosylation_sequon" }, { "start_pos": 634, "end_pos": 636, "annotation": "n_glycosylation_sequon" }, { "start_pos": 677, "end_pos": 679, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" }, { "start_pos": 942, "end_pos": 944, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4S9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1016, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4S9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4S9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 182, "end_pos": 184 }, { "start_pos": 279, "end_pos": 281 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 525, "end_pos": 527 }, { "start_pos": 582, "end_pos": 584 }, { "start_pos": 605, "end_pos": 607 }, { "start_pos": 634, "end_pos": 636 }, { "start_pos": 677, "end_pos": 679 }, { "start_pos": 808, "end_pos": 810 }, { "start_pos": 942, "end_pos": 944 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4U2-1", "uniprot_ac": "F1N4U2", "uniprot_id": "F1N4U2_BOVIN", "mass": { "chemical_mass": 35556.0, "monoisotopic_mass": 35556.0 }, "refseq": { "ac": "NP_001377250", "name": "olfactory receptor family 51 subfamily H member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377250" }, "gene_names": [ { "name": "OR51H1", "type": "recommended", "evidence": [ { "id": "F1N4U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" } ] }, { "name": "OR51H1", "type": "synonym", "evidence": [ { "id": "NP_001377250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377250" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N4U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 51 subfamily H member 1", "type": "synonym", "evidence": [ { "id": "NP_001377250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377250" } ] }, { "name": "putative olfactory receptor 51H1", "type": "synonym", "evidence": [ { "id": "NP_001377250", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377250" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377250" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51H1", "url": "https://www.uniprot.org/uniprotkb/F1N4U2", "locus": { "chromosome": "15", "start_pos": 48862185, "end_pos": 48863135, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014853", "url": "https://www.ensembl.org/id/ENSBTAG00000014853" } ] } } ], "crossref": [ { "id": "F1N4U2", "url": "https://alphafold.ebi.ac.uk/entry/F1N4U2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782373", "url": "https://www.ncbi.nlm.nih.gov/gene/782373", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782373", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782373", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377250", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4U2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMNTSSSHVNHHSFILTGIPGMPDKNPWMAFPLGFLYTMTLLGNGTILAIIKVDRSLHEPMYYFLSILALTDVGLSMSTLPSMLSIFWFNAPEVPFDACITQMFFIHSFGEVESGVLVSMAFDRFVAIRDPLHYASILTHGIIGKIGIAVIIRAVCVVFPVPFLIKRLPFCHSNVLSHSYCLHQDAMRLACASTRVNSLYGLIVVIFTLGFDAFIILFSYVLILKTVLDIASRAERLKALNTCLSHICAVLLFYVPLIGVTMIHRFGKHLSPVVHTFMANTYLLLPPLLNPVVYSVKTKQIQRRIIHVFQRRKNRV", "length": 316, "header": "tr|F1N4U2-1|F1N4U2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51H1 PE=3 SV=4 CANONICAL=F1N4U2-1" }, "isoforms": [ { "isoform_ac": "F1N4U2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U2/entry", "sequence": { "sequence": "MMNTSSSHVNHHSFILTGIPGMPDKNPWMAFPLGFLYTMTLLGNGTILAIIKVDRSLHEPMYYFLSILALTDVGLSMSTLPSMLSIFWFNAPEVPFDACITQMFFIHSFGEVESGVLVSMAFDRFVAIRDPLHYASILTHGIIGKIGIAVIIRAVCVVFPVPFLIKRLPFCHSNVLSHSYCLHQDAMRLACASTRVNSLYGLIVVIFTLGFDAFIILFSYVLILKTVLDIASRAERLKALNTCLSHICAVLLFYVPLIGVTMIHRFGKHLSPVVHTFMANTYLLLPPLLNPVVYSVKTKQIQRRIIHVFQRRKNRV", "length": 316, "header": "tr|F1N4U2-1|F1N4U2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51H1 PE=3 SV=4 CANONICAL=F1N4U2-1" }, "locus": { "chromosome": "15", "start_pos": 48863135, "end_pos": 48862188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019780.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019780.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019780.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019780.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782373", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782373", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "F1N4U2", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4U2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4U2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4U2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4U5-1", "uniprot_ac": "F1N4U5", "uniprot_id": "F1N4U5_BOVIN", "mass": { "chemical_mass": 60259.0, "monoisotopic_mass": 60259.0 }, "refseq": {}, "gene_names": [ { "name": "GPATCH3", "type": "recommended", "evidence": [ { "id": "F1N4U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ] } ], "protein_names": [ { "name": "G-patch domain containing 3", "type": "synonym", "evidence": [ { "id": "F1N4U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPATCH3", "url": "https://www.uniprot.org/uniprotkb/F1N4U5", "locus": { "chromosome": "2", "start_pos": 126321490, "end_pos": 126314527, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014849", "url": "https://www.ensembl.org/id/ENSBTAG00000014849" } ] } } ], "crossref": [ { "id": "F1N4U5", "url": "https://alphafold.ebi.ac.uk/entry/F1N4U5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4U5", "url": "https://www.orthodb.org/?gene=F1N4U5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14390:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14390:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4U5-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSRELVPADHVTAKMAVSSEAEEEAVVYLVVSGIPSELRSAQLRNYFSQFREQRDCGFLCFHYRHRPERAPPQAAPDCTPTPIRQGLAQTSLNDAGALSTQDSNPTRTRTCCCVVSVRGAAQAQRFLRMYSGRRWLDSQGTWLPGRCFIRRLRLPTEASGLGSFPFKTRKELQSRQAKSETFTLADLRQLPELNPPVLMPNGNVGTPLRVFLELIRACRLPPRIITQLQLQFPKTGSSRRYGNVPFTYEDSETVEQEEFVYTAEGEEIPQGSCLADIPSNSREEPEEEEEEEEESHSDDDDDRGEEWERHVALHEDVTGQERTSERLFEEEIELKWEKGGSGLVFYTDAQFWQEEEGDFDEQTADDWDVDMSVYYDTDGGDKDARDSVQMRLERRLRDGQEAGSVIRHQVGTFERHTKGIGRKVLERQGWAEGQGLGSQCSGVPDALDNDGQHPRCKRGLGYHGEKLQPFGQPKRPRGTGLGLISTIYDEPLPQDQGELLLRRQPPTSMKFRTEAFVRSSSCALNSLSEPE", "length": 532, "header": "tr|F1N4U5-1|F1N4U5_BOVIN Isoform 1 of G-patch domain containing 3 OS=Bos taurus OX=9913 GN=GPATCH3 PE=4 SV=2 CANONICAL=F1N4U5-1" }, "isoforms": [ { "isoform_ac": "F1N4U5-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U5/entry", "sequence": { "sequence": "MFSRELVPADHVTAKMAVSSEAEEEAVVYLVVSGIPSELRSAQLRNYFSQFREQRDCGFLCFHYRHRPERAPPQAAPDCTPTPIRQGLAQTSLNDAGALSTQDSNPTRTRTCCCVVSVRGAAQAQRFLRMYSGRRWLDSQGTWLPGRCFIRRLRLPTEASGLGSFPFKTRKELQSRQAKSETFTLADLRQLPELNPPVLMPNGNVGTPLRVFLELIRACRLPPRIITQLQLQFPKTGSSRRYGNVPFTYEDSETVEQEEFVYTAEGEEIPQGSCLADIPSNSREEPEEEEEEEEESHSDDDDDRGEEWERHVALHEDVTGQERTSERLFEEEIELKWEKGGSGLVFYTDAQFWQEEEGDFDEQTADDWDVDMSVYYDTDGGDKDARDSVQMRLERRLRDGQEAGSVIRHQVGTFERHTKGIGRKVLERQGWAEGQGLGSQCSGVPDALDNDGQHPRCKRGLGYHGEKLQPFGQPKRPRGTGLGLISTIYDEPLPQDQGELLLRRQPPTSMKFRTEAFVRSSSCALNSLSEPE", "length": 532, "header": "tr|F1N4U5-1|F1N4U5_BOVIN Isoform 1 of G-patch domain containing 3 OS=Bos taurus OX=9913 GN=GPATCH3 PE=4 SV=2 CANONICAL=F1N4U5-1" }, "locus": { "chromosome": "2", "start_pos": 126320973, "end_pos": 126314704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019773.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019773.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019773.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019773.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "pmid": "" }, { "name": "negative regulation of RIG-I signaling pathway", "id": "GO:0039536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039536", "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1N4U5", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4U5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 532, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4U5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4U5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U5" }, { "id": "PS50174", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000259", "start_pos": 418, "end_pos": 466, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4U7-1", "uniprot_ac": "F1N4U7", "uniprot_id": "F1N4U7_BOVIN", "mass": { "chemical_mass": 41418.0, "monoisotopic_mass": 41418.0 }, "refseq": {}, "gene_names": [ { "name": "BARHL2", "type": "recommended", "evidence": [ { "id": "F1N4U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ] } ], "protein_names": [ { "name": "BarH like homeobox 2", "type": "synonym", "evidence": [ { "id": "F1N4U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BARHL2", "url": "https://www.uniprot.org/uniprotkb/F1N4U7", "locus": { "chromosome": "3", "start_pos": 52537696, "end_pos": 52531871, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005938", "url": "https://www.ensembl.org/id/ENSBTAG00000005938" } ] } } ], "crossref": [ { "id": "F1N4U7", "url": "https://alphafold.ebi.ac.uk/entry/F1N4U7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4U7", "url": "https://www.orthodb.org/?gene=F1N4U7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24330", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24330", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24330:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24330:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4U7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TTTMEGASGSSFGIDTILSSASSGSPGMMNGDFRPLGEARTADFRSQATPSPCSEIDTVGTAPSSPISVTMEPPEPHLIADGPQHHHHLHHSQQPPPAAAPPQSLQPSPQQQQQPPPPPAAQQLGSAASAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAAHESFRPKLEQEDSKTKLDKREESQSDVKCHGTKEEGDREISSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR", "length": 383, "header": "tr|F1N4U7-1|F1N4U7_BOVIN Isoform 1 of BarH like homeobox 2 OS=Bos taurus OX=9913 GN=BARHL2 PE=3 SV=3 CANONICAL=F1N4U7-1" }, "isoforms": [ { "isoform_ac": "F1N4U7-1", "url": "https://www.uniprot.org/uniprotkb/F1N4U7/entry", "sequence": { "sequence": "TTTMEGASGSSFGIDTILSSASSGSPGMMNGDFRPLGEARTADFRSQATPSPCSEIDTVGTAPSSPISVTMEPPEPHLIADGPQHHHHLHHSQQPPPAAAPPQSLQPSPQQQQQPPPPPAAQQLGSAASAPRTSTSSFLIKDILGDSKPLAACAPYSTSVSSPHHTPKQESNAAHESFRPKLEQEDSKTKLDKREESQSDVKCHGTKEEGDREISSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR", "length": 383, "header": "tr|F1N4U7-1|F1N4U7_BOVIN Isoform 1 of BarH like homeobox 2 OS=Bos taurus OX=9913 GN=BARHL2 PE=3 SV=3 CANONICAL=F1N4U7-1" }, "locus": { "chromosome": "3", "start_pos": 52536692, "end_pos": 52532070, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007796.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007796.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007796.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007796.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 49, "start_aa": "Thr", "end_pos": 49, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1N4U7", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4U7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 383, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4U7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4U7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4U7" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 226, "end_pos": 286, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 49 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 266, "end_pos": 268 }, { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4W9-1", "uniprot_ac": "F1N4W9", "uniprot_id": "F1N4W9_BOVIN", "mass": { "chemical_mass": 193292.0, "monoisotopic_mass": 193292.0 }, "refseq": {}, "gene_names": [ { "name": "SCN7A", "type": "recommended", "evidence": [ { "id": "F1N4W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ] } ], "protein_names": [ { "name": "Sodium channel protein type 7 subunit alpha", "type": "recommended", "evidence": [ { "id": "F1N4W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4W9/entry#names_and_taxonomy" } ] }, { "name": "Nax channel", "type": "synonym", "evidence": [ { "id": "F1N4W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4W9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis.", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9#function" }, { "database": "UniProtKB", "id": "ARBA00055010", "url": "https://www.uniprot.org/uniprotkb/ARBA00055010#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCN7A", "url": "https://www.uniprot.org/uniprotkb/F1N4W9", "locus": { "chromosome": "2", "start_pos": 29898401, "end_pos": 29836931, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019137", "url": "https://www.ensembl.org/id/ENSBTAG00000019137" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019137", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019137", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13433", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13433", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4W9", "url": "https://www.orthodb.org/?gene=F1N4W9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10037:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06512", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06512", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24609", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24609", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "34963", "url": "https://www.rhea-db.org/rhea/34963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4W9-1", "url": "https://www.uniprot.org/uniprotkb/F1N4W9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSPEPKSLVPFTRESLEVMEQHSAKKPSEEDKEDLKPNCDLEVGKELPFAYGNLPQAMVSEPLEDVDPYYTNKRTFIVLNKKRTIFRFNATWCTLSPFNSIRRATIKILVHPFFRLFILVSVLTDCIYMSMTDLPKWGPALQNTLLGIYTFEILVKLIARGIWAGPFYFFGDSWNWLDFSVTLFEHISRYSPLNFISVCRIMRNLRILKIIPLNQGLKSFVAILIHCLKKLTVVIILTLFFLSVFSLIGMGLFMGNLKHKCLRWPQENETDMLNNRTGNPYYIRETENFYYLEGERYALLCGNRSDASQCPEGYVCVKAGVNPDDGYTNFDSFGWALLALFRLMTQDYPEALYHQILYASGKVYMVFFVVISFWFAFYMASLFLGLLAISYEEEKQTAAEKATIDQEFQKSLPELQEEKITAETKTIQIEMKKRSSTSVITSLDVLGDATISHKEELKKSRQRCPFCWYEFAKTFLIWDCSPCWLKLKEFVHRIIMDPFTDLFLTICIILNIHFLALEHYPMSLETSNILSIGNVVFIGIFTAEMIFKIIAMYPYGYFQVGWNIYDSLIVFHGLAELYLTNFHGLAILRSFRVLRIFRLGRYWPTFKILMLTLCNSIVALKDLVLLLFTFIFFSAVVGLNLYGSKYKKYVCSINEDCQLPHWHMHDFFHSFLNVFRILCGEWIETLWDCFKVAGQFSCIPFYMMVILIGKLLILYLFLALIISFSSYKPATTEEFSEEAKNLQRAMARIKKGINYLLSKIVCKKQNVLEETMDNISDVYVKENISDHTLSELSNTQDFLKDKEKSSGTEKNTMTENESQSLIPSPSVSETVPIASEESDIENPDNKEIQSKSGDGSSKEKVKQSSSSECSTVDIVLSEEEMVYECEKPKHLRNVYERRSSSAQIGRGPQKGKIWKNIRKTCCKIVENNCFKCFIGLVTLLSTGALAFEDIYIDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFTNGWYKLDFMVVIVFCLSLIGKSREELKPLVSIKFLRALRVLSQFEKMKVVVRALIKTTLPTLNVFLVCLMIWLAFGIIGVHLFAGKFYECIDPTSGERFPLSEVMNRSQCESLVFNESMPWENAKLNFDNVGISFFSLLQVATFNGWITIMNSAVDSTDVDMQPNFENNIYMYCYFIDFIIIGLFLPLSMLIGDIVANFHKHKIKQGGSNIFITVKQKKQYRALKKLMYEDSQQPVPLPENKFQRFIFDLVTSRVFNIIIMTLICFQAITIMIQSDEQSPKIDTALFWINSVYVMLYIGECVLKLIVFHCNYFTSGWNIFDFMVVVFSITGLFLPLMVGYYLVSPSLVQLILLSRIIHILHPEKGLKLFHNLLLPLMLSLPALLNISLLIFLIMFIYAIFGMYNFAYVKKEAGIDDMSNFETFSSSMLCLFRVTIFAGWDGMLNAVFNSKWSDCDPNKINPGTQIRGDCGNPFLGIIYFVSYILLTRLIIVNMYIVVVMEFLNIASKKKAKTLSEEDFRKFFQVWKRFDPERTQYIDSSKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAVGDRIHCLDVLLALTKRVLGKDLSMEKVLSEMESGLTLANTFKITYEPITTTLKRKQEVVSATIIQRAYKSYRLRQNDKNTSDTHMIDGDREVQAIKEDSYIDKAEGVSILQSQI", "length": 1677, "header": "tr|F1N4W9-1|F1N4W9_BOVIN Isoform 1 of Sodium channel protein type 7 subunit alpha OS=Bos taurus OX=9913 GN=SCN7A PE=3 SV=4 CANONICAL=F1N4W9-1" }, "isoforms": [ { "isoform_ac": "F1N4W9-1", "url": "https://www.uniprot.org/uniprotkb/F1N4W9/entry", "sequence": { "sequence": "MVSPEPKSLVPFTRESLEVMEQHSAKKPSEEDKEDLKPNCDLEVGKELPFAYGNLPQAMVSEPLEDVDPYYTNKRTFIVLNKKRTIFRFNATWCTLSPFNSIRRATIKILVHPFFRLFILVSVLTDCIYMSMTDLPKWGPALQNTLLGIYTFEILVKLIARGIWAGPFYFFGDSWNWLDFSVTLFEHISRYSPLNFISVCRIMRNLRILKIIPLNQGLKSFVAILIHCLKKLTVVIILTLFFLSVFSLIGMGLFMGNLKHKCLRWPQENETDMLNNRTGNPYYIRETENFYYLEGERYALLCGNRSDASQCPEGYVCVKAGVNPDDGYTNFDSFGWALLALFRLMTQDYPEALYHQILYASGKVYMVFFVVISFWFAFYMASLFLGLLAISYEEEKQTAAEKATIDQEFQKSLPELQEEKITAETKTIQIEMKKRSSTSVITSLDVLGDATISHKEELKKSRQRCPFCWYEFAKTFLIWDCSPCWLKLKEFVHRIIMDPFTDLFLTICIILNIHFLALEHYPMSLETSNILSIGNVVFIGIFTAEMIFKIIAMYPYGYFQVGWNIYDSLIVFHGLAELYLTNFHGLAILRSFRVLRIFRLGRYWPTFKILMLTLCNSIVALKDLVLLLFTFIFFSAVVGLNLYGSKYKKYVCSINEDCQLPHWHMHDFFHSFLNVFRILCGEWIETLWDCFKVAGQFSCIPFYMMVILIGKLLILYLFLALIISFSSYKPATTEEFSEEAKNLQRAMARIKKGINYLLSKIVCKKQNVLEETMDNISDVYVKENISDHTLSELSNTQDFLKDKEKSSGTEKNTMTENESQSLIPSPSVSETVPIASEESDIENPDNKEIQSKSGDGSSKEKVKQSSSSECSTVDIVLSEEEMVYECEKPKHLRNVYERRSSSAQIGRGPQKGKIWKNIRKTCCKIVENNCFKCFIGLVTLLSTGALAFEDIYIDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFTNGWYKLDFMVVIVFCLSLIGKSREELKPLVSIKFLRALRVLSQFEKMKVVVRALIKTTLPTLNVFLVCLMIWLAFGIIGVHLFAGKFYECIDPTSGERFPLSEVMNRSQCESLVFNESMPWENAKLNFDNVGISFFSLLQVATFNGWITIMNSAVDSTDVDMQPNFENNIYMYCYFIDFIIIGLFLPLSMLIGDIVANFHKHKIKQGGSNIFITVKQKKQYRALKKLMYEDSQQPVPLPENKFQRFIFDLVTSRVFNIIIMTLICFQAITIMIQSDEQSPKIDTALFWINSVYVMLYIGECVLKLIVFHCNYFTSGWNIFDFMVVVFSITGLFLPLMVGYYLVSPSLVQLILLSRIIHILHPEKGLKLFHNLLLPLMLSLPALLNISLLIFLIMFIYAIFGMYNFAYVKKEAGIDDMSNFETFSSSMLCLFRVTIFAGWDGMLNAVFNSKWSDCDPNKINPGTQIRGDCGNPFLGIIYFVSYILLTRLIIVNMYIVVVMEFLNIASKKKAKTLSEEDFRKFFQVWKRFDPERTQYIDSSKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAVGDRIHCLDVLLALTKRVLGKDLSMEKVLSEMESGLTLANTFKITYEPITTTLKRKQEVVSATIIQRAYKSYRLRQNDKNTSDTHMIDGDREVQAIKEDSYIDKAEGVSILQSQI", "length": 1677, "header": "tr|F1N4W9-1|F1N4W9_BOVIN Isoform 1 of Sodium channel protein type 7 subunit alpha OS=Bos taurus OX=9913 GN=SCN7A PE=3 SV=4 CANONICAL=F1N4W9-1" }, "locus": { "chromosome": "2", "start_pos": 29898083, "end_pos": 29836931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038441.7", "url": "https://www.ensembl.org/id/ENSBTAT00000038441.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038254.6", "url": "https://www.ensembl.org/id/ENSBTAP00000038254.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1086, "start_aa": "Thr", "end_pos": 1086, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1086", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "osmosensory signaling pathway", "id": "GO:0007231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007231", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "sodium ion homeostasis", "id": "GO:0055078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055078", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "voltage-gated sodium channel complex", "id": "GO:0001518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001518", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "glial cell projection", "id": "GO:0097386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097386", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "sodium channel activity", "id": "GO:0005272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005272", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "voltage-gated sodium channel activity", "id": "GO:0005248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005248", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" }, { "name": "osmolarity-sensing monoatomic cation channel activity", "id": "GO:1990760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990760", "evidence": [ { "database": "UniProtKB", "id": "F1N4W9", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1098, "end_pos": 1100, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1108, "end_pos": 1110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1377, "end_pos": 1379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1642, "end_pos": 1644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" }, { "start_pos": 775, "end_pos": 777, "annotation": "n_glycosylation_sequon" }, { "start_pos": 784, "end_pos": 786, "annotation": "n_glycosylation_sequon" }, { "start_pos": 817, "end_pos": 819, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "34963", "name": "", "equation": "Na(+)(in) = Na(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "34963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34963" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N4W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 398, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" }, { "id": "PF24609", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24609" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCN5A-like C-terminal IQ motif", "eco_id": "ECO_0000259", "start_pos": 1613, "end_pos": 1645, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N4W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4W9" }, { "id": "PF06512", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06512" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sodium ion transport-associated", "eco_id": "ECO_0000259", "start_pos": 739, "end_pos": 922, "start_aa": "Glu", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1086 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1098, "end_pos": 1100 }, { "start_pos": 1108, "end_pos": 1110 }, { "start_pos": 1377, "end_pos": 1379 }, { "start_pos": 1642, "end_pos": 1644 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 304, "end_pos": 306 }, { "start_pos": 775, "end_pos": 777 }, { "start_pos": 784, "end_pos": 786 }, { "start_pos": 817, "end_pos": 819 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N4X3-1", "uniprot_ac": "F1N4X3", "uniprot_id": "F1N4X3_BOVIN", "mass": { "chemical_mass": 105608.0, "monoisotopic_mass": 105608.0 }, "refseq": { "ac": "XP_010808992", "name": "TSC22 domain family protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808992" }, "gene_names": [ { "name": "TSC22D1", "type": "recommended", "evidence": [ { "id": "F1N4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ] }, { "name": "TSC22D1", "type": "synonym", "evidence": [ { "id": "XP_010808992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808992" } ] } ], "protein_names": [ { "name": "TSC22 domain family member 1", "type": "synonym", "evidence": [ { "id": "F1N4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4X3/entry#names_and_taxonomy" } ] }, { "name": "TSC22 domain family protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010808992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808992" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSC22D1", "url": "https://www.uniprot.org/uniprotkb/F1N4X3", "locus": { "chromosome": "12", "start_pos": 14678163, "end_pos": 14681581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047739", "url": "https://www.ensembl.org/id/ENSBTAG00000047739" } ] } } ], "crossref": [ { "id": "F1N4X3", "url": "https://alphafold.ebi.ac.uk/entry/F1N4X3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046664", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046664", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510359", "url": "https://www.ncbi.nlm.nih.gov/gene/510359", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F1N4X3", "url": "https://www.orthodb.org/?gene=F1N4X3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46745", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46745", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46745:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46745:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_010808992", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808992", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NTW4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTW4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4X3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4X3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHQPPESTAAAAAADMSARKMAHPAMFPRRGSGGGSASALGAAGTGVGSSAPSAEDFPPPSLLQPPPPAASSLSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHPLHHHHPIHGHHLHHGHHHPSHAGVASTSIPGGPPSSPVSRKLSAAGSSDGVMPVAPTSAVSLSGSPASVMTSVRAPSTTGSLGINSVTGTNTMNNVNVTAVGSFNPPVTSSMLGNANISVSSIPSAASVSVGPAVSSGVNVNILSGMGNGTIASSAAFNSAANAAAGMTVGSVSSQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKENAAVPATEGVVVNKVVESVRQNPTEATSERESTSGSSVSSSVSTLSHYTESVGSGEMGTLAAPPVPPTLPGVALPQMDFSSAAPQGISAVSMPQSISQSQISQVQLPSQELGYQPKPGLQPVPLQAGIQPSPVGVVGVTSALGQQPSVASLAQPQLPYSQAAPPVQAPLPGAPPQQVQYSQPAPAVGPPMAPSHGTSVAPNPASEYVQPSPLLQTAVSSGQPTSAGVAVGATVIPMAQPQSIQLPVQPAAVQAQPAGAAGQPVGKAHTTVAAVPPGSQIATIGQQTSLPSALQQPSTQVTPSVIQQGAPPSSQIVPPAPAAILHQGVQPSASGLPQQLVIAPQSTLLPVPPQPQGVESVAPGVVSKQLPAVSPLPSASSISVTNQVSSAGPSGLPSAPTNLVPSQNIAQAPVTQNGNLVQSVSQPPLLASNINLPLAQQLPLSSVQFSAQSLAQAIGSQIEDARRPAEPSLVGLPQTISGDSGGVSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESASLLPEVQGVILEPQIQPRPRRAFDVRGPLSPLNLWRQNIQLLERVGKGFLSTGKHPPSAKGTPLAEPSRMISVTHAATAVWKAVVNGAMHYV", "length": 1045, "header": "tr|F1N4X3-1|F1N4X3_BOVIN Isoform 1 of TSC22 domain family member 1 OS=Bos taurus OX=9913 GN=TSC22D1 PE=4 SV=3 CANONICAL=F1N4X3-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NTW4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTW4/entry", "sequence": { "sequence": "MHQPPESTAAAAAADMSARKMAHPAMFPRRGSGGGSASALGAAGTGVGSSAPSAEDFPPPSLLQPPPPAASSLSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHPLHHHHPIHGHHLHHGHHHPSHAGVASTSIPGGPPSSPVSRKLSAAGSSDGVMPVAPTSAVSLSGSPASVMTSVRAPSTTGSLGINSVTGTNTMNNVNVTAVGSFNPPVTSSMLGNANISVSSIPSAASVSVGPAVSSGVNVNILSGMGNGTIASSAAFNSAANAAAGMTVGSVSSQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKENAAVPATEGVVVNKVVESVRQNPTEATSERESTSGSSVSSSVSTLSHYTESVGSGEMGTLAAPPVPPTLPGVALPQMDFSSAAPQGISAVSMPQSISQSQISQVQLPSQELGYQPKPGLQPVPLQAGIQPSPVGVVGVTSALGQQPSVASLAQPQLPYSQAAPPVQAPLPGAPPQQVQYSQPAPAVGPPMAPSHGTSVAPNPASEYVQPSPLLQTAVSSGQPTSAGVAVGATVIPMAQPQSIQLPVQPAAVQAQPAGAAGQPVGKAHTTVAAVPPGSQIATIGQQTSLPSALQQPSTQVTPSVIQQGAPPSSQIVPPAPAAILHQGVQPSASGLPQQLVIAPQSTLLPVPPQPQGVESVAPGVVSKQLPAVSPLPSASSISVTNQVSSAGPSGLPSAPTNLVPSQNIAQAPVTQNGNLVQSVSQPPLLASNINLPLAQQLPLSSVQFSAQSLAQAIGSQIEDARRPAEPSLVGLPQTISGDSGGVSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESCWHFSKLAGRARRK", "length": 966, "header": "tr|A0ABI0NTW4-1|A0ABI0NTW4_BOVIN Computationally mapped isoform of TSC22 domain family member 1 OS=Bos taurus OX=9913 GN=TSC22D1 PE=4 SV=1 CANONICAL=F1N4X3-1" }, "locus": { "chromosome": "12", "start_pos": 14801118, "end_pos": 14772127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153063.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153063.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106979.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106979.1" } ] } }, { "isoform_ac": "F1N4X3-1", "url": "https://www.uniprot.org/uniprotkb/F1N4X3/entry", "sequence": { "sequence": "MHQPPESTAAAAAADMSARKMAHPAMFPRRGSGGGSASALGAAGTGVGSSAPSAEDFPPPSLLQPPPPAASSLSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHPLHHHHPIHGHHLHHGHHHPSHAGVASTSIPGGPPSSPVSRKLSAAGSSDGVMPVAPTSAVSLSGSPASVMTSVRAPSTTGSLGINSVTGTNTMNNVNVTAVGSFNPPVTSSMLGNANISVSSIPSAASVSVGPAVSSGVNVNILSGMGNGTIASSAAFNSAANAAAGMTVGSVSSQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKENAAVPATEGVVVNKVVESVRQNPTEATSERESTSGSSVSSSVSTLSHYTESVGSGEMGTLAAPPVPPTLPGVALPQMDFSSAAPQGISAVSMPQSISQSQISQVQLPSQELGYQPKPGLQPVPLQAGIQPSPVGVVGVTSALGQQPSVASLAQPQLPYSQAAPPVQAPLPGAPPQQVQYSQPAPAVGPPMAPSHGTSVAPNPASEYVQPSPLLQTAVSSGQPTSAGVAVGATVIPMAQPQSIQLPVQPAAVQAQPAGAAGQPVGKAHTTVAAVPPGSQIATIGQQTSLPSALQQPSTQVTPSVIQQGAPPSSQIVPPAPAAILHQGVQPSASGLPQQLVIAPQSTLLPVPPQPQGVESVAPGVVSKQLPAVSPLPSASSISVTNQVSSAGPSGLPSAPTNLVPSQNIAQAPVTQNGNLVQSVSQPPLLASNINLPLAQQLPLSSVQFSAQSLAQAIGSQIEDARRPAEPSLVGLPQTISGDSGGVSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESASLLPEVQGVILEPQIQPRPRRAFDVRGPLSPLNLWRQNIQLLERVGKGFLSTGKHPPSAKGTPLAEPSRMISVTHAATAVWKAVVNGAMHYV", "length": 1045, "header": "tr|F1N4X3-1|F1N4X3_BOVIN Isoform 1 of TSC22 domain family member 1 OS=Bos taurus OX=9913 GN=TSC22D1 PE=4 SV=3 CANONICAL=F1N4X3-1" }, "locus": { "chromosome": "12", "start_pos": 14801118, "end_pos": 14769665, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054608.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054608.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052538.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052538.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 275, "start_aa": "Thr", "end_pos": 275, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr275", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 731, "start_aa": "Thr", "end_pos": 731, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr731", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "F1N4X3", "url": "https://www.uniprot.org/uniprotkb/F1N4X3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N4X3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1045, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N4X3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N4X3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 275, 731 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 335, "end_pos": 337 }, { "start_pos": 367, "end_pos": 369 }, { "start_pos": 401, "end_pos": 403 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N524-1", "uniprot_ac": "F1N524", "uniprot_id": "F1N524_BOVIN", "mass": { "chemical_mass": 106119.0, "monoisotopic_mass": 106119.0 }, "refseq": { "ac": "XP_005221021", "name": "meiosis-specific coiled-coil domain-containing protein MEIOC", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221021" }, "gene_names": [ { "name": "MEIOC", "type": "recommended", "evidence": [ { "id": "F1N524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ] }, { "name": "MEIOC", "type": "synonym", "evidence": [ { "id": "XP_005221021", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221021" } ] } ], "protein_names": [ { "name": "Meiosis specific with coiled-coil domain", "type": "synonym", "evidence": [ { "id": "F1N524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N524/entry#names_and_taxonomy" } ] }, { "name": "meiosis-specific coiled-coil domain-containing protein MEIOC", "type": "synonym", "evidence": [ { "id": "XP_005221021", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221021" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEIOC", "url": "https://www.uniprot.org/uniprotkb/F1N524", "locus": { "chromosome": "19", "start_pos": 44425221, "end_pos": 44410594, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039485", "url": "https://www.ensembl.org/id/ENSBTAG00000039485" } ] } } ], "crossref": [ { "id": "F1N524", "url": "https://alphafold.ebi.ac.uk/entry/F1N524", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039485", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039485", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540078", "url": "https://www.ncbi.nlm.nih.gov/gene/540078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N524", "url": "https://www.orthodb.org/?gene=F1N524", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33861:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33861:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221021", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221021", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N524-1", "url": "https://www.uniprot.org/uniprotkb/F1N524-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPKVAFRGGANRCWNLSADASSRLTDVFNSVVLTGSPSFYDCYKSQNEDSVDLRQTYAPLSSSTEYASSVDSSLFYAPWSTYGDDIKQPSNSQINVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFADHHDLLTETKRPVDTAISQQAFYTGESVSAVEKQYLHNSNLIPQQKIDELYHGFTGLDLEEQWMYPSRNDHSNCYNIQPNDTAKTAFQEYPFIKNCFTPQTGLSDIMKESGVDTYSYGREKICAKGLEAPLQQKRAEIFLSQFNRYSENPDYCRYPEYAHPNKAKLSKCSNFSVQDSKKLASATPETPTVEADTYTKLFQVKPANQKKMEETIPDQQNFTFPKTTPHLTEKQFGKEAAFTADFGLKSEYGLKPHTTCSANNDFANVTEKQQFTKPDPPNSEYFKSVNLLANSATSSGGINLNRPTWMNVQTKNNTPIFYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTPNSNLFQKYCQENPSAFSSFDFGYSGAERIQSINHMEGLTKTGEENLFESVTDKKIKQPNGFCDNYSAQQYGIIESVNKHNFQAKPQSGHYDPEEGPKHLDGLSQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQSFQQLGSSGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKARTTLWCALQMTLPKTASTAGQTDVEKALQDIVNCEDKVHESLNSSNPVNQRGEANKH", "length": 940, "header": "tr|F1N524-1|F1N524_BOVIN Isoform 1 of Meiosis specific with coiled-coil domain OS=Bos taurus OX=9913 GN=MEIOC PE=4 SV=3 CANONICAL=F1N524-1" }, "isoforms": [ { "isoform_ac": "F1N524-1", "url": "https://www.uniprot.org/uniprotkb/F1N524/entry", "sequence": { "sequence": "MEPKVAFRGGANRCWNLSADASSRLTDVFNSVVLTGSPSFYDCYKSQNEDSVDLRQTYAPLSSSTEYASSVDSSLFYAPWSTYGDDIKQPSNSQINVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFADHHDLLTETKRPVDTAISQQAFYTGESVSAVEKQYLHNSNLIPQQKIDELYHGFTGLDLEEQWMYPSRNDHSNCYNIQPNDTAKTAFQEYPFIKNCFTPQTGLSDIMKESGVDTYSYGREKICAKGLEAPLQQKRAEIFLSQFNRYSENPDYCRYPEYAHPNKAKLSKCSNFSVQDSKKLASATPETPTVEADTYTKLFQVKPANQKKMEETIPDQQNFTFPKTTPHLTEKQFGKEAAFTADFGLKSEYGLKPHTTCSANNDFANVTEKQQFTKPDPPNSEYFKSVNLLANSATSSGGINLNRPTWMNVQTKNNTPIFYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTPNSNLFQKYCQENPSAFSSFDFGYSGAERIQSINHMEGLTKTGEENLFESVTDKKIKQPNGFCDNYSAQQYGIIESVNKHNFQAKPQSGHYDPEEGPKHLDGLSQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQSFQQLGSSGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKARTTLWCALQMTLPKTASTAGQTDVEKALQDIVNCEDKVHESLNSSNPVNQRGEANKH", "length": 940, "header": "tr|F1N524-1|F1N524_BOVIN Isoform 1 of Meiosis specific with coiled-coil domain OS=Bos taurus OX=9913 GN=MEIOC PE=4 SV=3 CANONICAL=F1N524-1" }, "locus": { "chromosome": "19", "start_pos": 44424217, "end_pos": 44410793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042938.6", "url": "https://www.ensembl.org/id/ENSBTAT00000042938.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040543.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040543.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540078", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "metaphase chromosome alignment", "id": "GO:0051310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051310", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "female meiosis I", "id": "GO:0007144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007144", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "mRNA stabilization", "id": "GO:0048255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048255", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "synaptonemal complex assembly", "id": "GO:0007130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "oocyte development", "id": "GO:0048599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048599", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "male meiosis I", "id": "GO:0007141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007141", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "germline cell cycle switching, mitotic to meiotic cell cycle", "id": "GO:0051729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051729", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N524", "url": "https://www.uniprot.org/uniprotkb/F1N524" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 777, "end_pos": 779, "annotation": "n_glycosylation_sequon" }, { "start_pos": 823, "end_pos": 825, "annotation": "n_glycosylation_sequon" }, { "start_pos": 848, "end_pos": 850, "annotation": "n_glycosylation_sequon" }, { "start_pos": 926, "end_pos": 928, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N524-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 940, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N524-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N524" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 16, "end_pos": 18 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 493, "end_pos": 495 }, { "start_pos": 505, "end_pos": 507 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 642, "end_pos": 644 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 777, "end_pos": 779 }, { "start_pos": 823, "end_pos": 825 }, { "start_pos": 848, "end_pos": 850 }, { "start_pos": 926, "end_pos": 928 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N532-1", "uniprot_ac": "F1N532", "uniprot_id": "F1N532_BOVIN", "mass": { "chemical_mass": 37996.0, "monoisotopic_mass": 37996.0 }, "refseq": {}, "gene_names": [ { "name": "EMG1", "type": "recommended", "evidence": [ { "id": "F1N532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ] } ], "protein_names": [ { "name": "18S rRNA (pseudouridine(1248)-N1)-methyltransferase", "type": "recommended", "evidence": [ { "id": "F1N532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N532/entry#names_and_taxonomy" } ] }, { "name": "18S rRNA Psi1248 methyltransferase", "type": "synonym", "evidence": [ { "id": "F1N532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N532/entry#names_and_taxonomy" } ] }, { "name": "Nucleolar protein EMG1 homolog", "type": "synonym", "evidence": [ { "id": "F1N532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N532/entry#names_and_taxonomy" } ] }, { "name": "Protein C2f", "type": "synonym", "evidence": [ { "id": "F1N532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N532/entry#names_and_taxonomy" } ] }, { "name": "Ribosome biogenesis protein NEP1", "type": "synonym", "evidence": [ { "id": "F1N532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N532/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMG1", "url": "https://www.uniprot.org/uniprotkb/F1N532", "locus": { "chromosome": "5", "start_pos": 103487268, "end_pos": 103493335, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013126", "url": "https://www.ensembl.org/id/ENSBTAG00000013126" } ] } } ], "crossref": [ { "id": "F1N532", "url": "https://alphafold.ebi.ac.uk/entry/F1N532", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013126", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013126", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18088", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18088", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ECKFSND", "url": "https://omabrowser.org/oma/group/ECKFSND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N532", "url": "https://www.orthodb.org/?gene=F1N532", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12636", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12636", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12636:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12636:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03587", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03587", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "46712", "url": "https://www.rhea-db.org/rhea/46712", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N532-1", "url": "https://www.uniprot.org/uniprotkb/F1N532-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPFTRGSGPQVLAGERAPEVCSFLNPPRSPRRTGAGAQEVRIRKSSPFLEPCPPREASQALDAESSPFLSAHFRNGRRKEAGDWGELEAGLRTLHNFRSGCKMAAPSGAFQPRERRAAEQEEDWDAVVPKRPRLGAGSKIGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSMLLKNGRDPGEVRPDIAHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVPVVSDVRELAPSSDPIVFVVGAFAHGKVDVEYTEKMVSISNYPLSAALTCAKVTTAFEEAWGVI", "length": 347, "header": "tr|F1N532-1|F1N532_BOVIN Isoform 1 of 18S rRNA (pseudouridine(1248)-N1)-methyltransferase OS=Bos taurus OX=9913 GN=EMG1 PE=3 SV=2 CANONICAL=F1N532-1" }, "isoforms": [ { "isoform_ac": "F1N532-1", "url": "https://www.uniprot.org/uniprotkb/F1N532/entry", "sequence": { "sequence": "MAPFTRGSGPQVLAGERAPEVCSFLNPPRSPRRTGAGAQEVRIRKSSPFLEPCPPREASQALDAESSPFLSAHFRNGRRKEAGDWGELEAGLRTLHNFRSGCKMAAPSGAFQPRERRAAEQEEDWDAVVPKRPRLGAGSKIGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSMLLKNGRDPGEVRPDIAHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVPVVSDVRELAPSSDPIVFVVGAFAHGKVDVEYTEKMVSISNYPLSAALTCAKVTTAFEEAWGVI", "length": 347, "header": "tr|F1N532-1|F1N532_BOVIN Isoform 1 of 18S rRNA (pseudouridine(1248)-N1)-methyltransferase OS=Bos taurus OX=9913 GN=EMG1 PE=3 SV=2 CANONICAL=F1N532-1" }, "locus": { "chromosome": "5", "start_pos": 103493136, "end_pos": 103487420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017445.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017445.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017445.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017445.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDS4-1", "protein_name": "18S rRNA (pseudouridine(1248)-N1)-methyltransferase", "gene_name": "Emg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATSGGFQPRERRFSVQEQDWDPAPPKRPRLGAGSKCGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPSSDPVVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI", "length": 244 }, "evidence": [ { "id": "F1N532", "url": "https://omabrowser.org/oma/group/F1N532/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GUQ7-1", "protein_name": "18S rRNA (pseudouridine(1248)-N1)-methyltransferase", "gene_name": "Emg1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAPSVGFQPRARRFAVQEPDWDHAPPKRPRLGAGSKSGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSMADVSDVRDMVPSSDPIVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKLTTAFEEVWGVV", "length": 244 }, "evidence": [ { "id": "F1N532", "url": "https://omabrowser.org/oma/group/F1N532/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LPQ4-1", "protein_name": "18S rRNA (pseudouridine(1248)-N1)-methyltransferase", "gene_name": "EMG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPSGGFQPRERRAGEQEEDWDAVAPKRPRLGAGSKTGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSMLLKNGRDPGEVRPDIAHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSIPVVSDVRELVPSSDPVVFVVGAFAHGQVDVEYTEKMVSISNYPLSAALTCAKLTTAFEEVWRVI", "length": 244 }, "evidence": [ { "id": "F1N532", "url": "https://omabrowser.org/oma/group/F1N532/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35130-1", "protein_name": "Ribosomal RNA small subunit methyltransferase NEP1", "gene_name": "Emg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAASGGFQPRERRFSVQEQDWETTPPKKLRLGAGSKCGGRRLIVVLEGASLETVKVGKTYELLNCDRHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPSSDPVVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI", "length": 244 }, "evidence": [ { "id": "F1N532", "url": "https://omabrowser.org/oma/group/F1N532/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92979-1", "protein_name": "Ribosomal RNA small subunit methyltransferase NEP1", "gene_name": "EMG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPSDGFKPRERSGGEQAQDWDALPPKRPRLGAGNKIGGRRLIVVLEGASLETVKVGKTYELLNCDKHKSILLKNGRDPGEARPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKVGTSFSIPVVSDVRELVPSSDPIVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKLTTAFEEVWGVI", "length": 244 }, "evidence": [ { "id": "F1N532", "url": "https://omabrowser.org/oma/group/F1N532/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" }, { "name": "rRNA (pseudouridine) methyltransferase activity", "id": "GO:0070037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070037", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" }, { "name": "rRNA base methylation", "id": "GO:0070475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070475", "evidence": [ { "database": "UniProtKB", "id": "F1N532", "url": "https://www.uniprot.org/uniprotkb/F1N532" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "46712", "name": "", "equation": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "46712", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46712" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N532-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 347, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N532-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N532" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N542-1", "uniprot_ac": "F1N542", "uniprot_id": "F1N542_BOVIN", "mass": { "chemical_mass": 106390.0, "monoisotopic_mass": 106390.0 }, "refseq": { "ac": "XP_024846945", "name": "lysine-specific demethylase 7A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846945" }, "gene_names": [ { "name": "KDM7A", "type": "recommended", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ] }, { "name": "KDM7A", "type": "synonym", "evidence": [ { "id": "XP_024846945", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846945" } ] } ], "protein_names": [ { "name": "Lysine-specific demethylase 7A", "type": "recommended", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542/entry#names_and_taxonomy" } ] }, { "name": "1.14.11.65", "type": "synonym", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542/entry#names_and_taxonomy" } ] }, { "name": "JmjC domain-containing histone demethylation protein 1D", "type": "synonym", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542/entry#names_and_taxonomy" } ] }, { "name": "Lysine-specific demethylase 7", "type": "synonym", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542/entry#names_and_taxonomy" } ] }, { "name": "[histone H3]-dimethyl-L-lysine9 demethylase 7A", "type": "synonym", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542/entry#names_and_taxonomy" } ] }, { "name": "lysine-specific demethylase 7A", "type": "synonym", "evidence": [ { "id": "XP_024846945", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846945" } ] } ], "function": [ { "annotation": "Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542#function" }, { "database": "UniProtKB", "id": "ARBA00056800", "url": "https://www.uniprot.org/uniprotkb/ARBA00056800#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KDM7A", "url": "https://www.uniprot.org/uniprotkb/F1N542", "locus": { "chromosome": "4", "start_pos": 103531103, "end_pos": 103604810, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003495", "url": "https://www.ensembl.org/id/ENSBTAG00000003495" } ] } } ], "crossref": [ { "id": "F1N542", "url": "https://alphafold.ebi.ac.uk/entry/F1N542", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003495", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003495", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15640", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15640", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521504", "url": "https://www.ncbi.nlm.nih.gov/gene/521504", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521504", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521504", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N542", "url": "https://www.orthodb.org/?gene=F1N542", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214842", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214842", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024846945", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846945", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21788", "url": "https://www.rhea-db.org/rhea/21788", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60188", "url": "https://www.rhea-db.org/rhea/60188", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67800", "url": "https://www.rhea-db.org/rhea/67800", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67804", "url": "https://www.rhea-db.org/rhea/67804", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N542-1", "url": "https://www.uniprot.org/uniprotkb/F1N542-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAAPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCALLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFVKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFEVPIMVPKLDDLGLRLPPPTFSVTDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFTNPNRPKVLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKVFYLIKPTDDNLALYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPSVCPVSRSSSEAASPYHSRRRMRKLRDHNVRTPSNLDILELHTREVLRRLEMCPWEEDILSSKLNGKFNKHLQPSSTVPEWRVKDNDLRLLLTNGRIIKDERQPFTDQSLYTADSENEEDKRRTKKAKVKMEESSGIEGVENEESQKPLNRFLTSVKSELRNRSSEYSDISDSEDSGPDCTVLKNNFTTEESESSGDEKKQEVTSNFKEESNVMRNFLQKSQKPSRSEIPVKRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCGGERPSLQDPSGCHSSNHEVRQLYRCDKTVESGYHVKTEDQDLRSSSWIKQFDTTSRFNLQDLNRGQKCIKKEVSSEISHKVQSRNSVDSSGSSLQNAKYTQSSSLISGACQLSNGSISPERPVGETSFSVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV", "length": 942, "header": "tr|F1N542-1|F1N542_BOVIN Isoform 1 of Lysine-specific demethylase 7A OS=Bos taurus OX=9913 GN=KDM7A PE=3 SV=3 CANONICAL=F1N542-1" }, "isoforms": [ { "isoform_ac": "F1N542-1", "url": "https://www.uniprot.org/uniprotkb/F1N542/entry", "sequence": { "sequence": "MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAAPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCALLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFVKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFEVPIMVPKLDDLGLRLPPPTFSVTDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFTNPNRPKVLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKVFYLIKPTDDNLALYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPSVCPVSRSSSEAASPYHSRRRMRKLRDHNVRTPSNLDILELHTREVLRRLEMCPWEEDILSSKLNGKFNKHLQPSSTVPEWRVKDNDLRLLLTNGRIIKDERQPFTDQSLYTADSENEEDKRRTKKAKVKMEESSGIEGVENEESQKPLNRFLTSVKSELRNRSSEYSDISDSEDSGPDCTVLKNNFTTEESESSGDEKKQEVTSNFKEESNVMRNFLQKSQKPSRSEIPVKRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCGGERPSLQDPSGCHSSNHEVRQLYRCDKTVESGYHVKTEDQDLRSSSWIKQFDTTSRFNLQDLNRGQKCIKKEVSSEISHKVQSRNSVDSSGSSLQNAKYTQSSSLISGACQLSNGSISPERPVGETSFSVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV", "length": 942, "header": "tr|F1N542-1|F1N542_BOVIN Isoform 1 of Lysine-specific demethylase 7A OS=Bos taurus OX=9913 GN=KDM7A PE=3 SV=3 CANONICAL=F1N542-1" }, "locus": { "chromosome": "4", "start_pos": 103604611, "end_pos": 103532107, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033494.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033494.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033407.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033407.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:521504", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521504", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214842", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214842", "resource": "Reactome", "description": "HDMs demethylate histones" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "histone H4K20 demethylase activity", "id": "GO:0035575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035575", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "histone H3K36 demethylase activity", "id": "GO:0051864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051864", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "histone demethylase activity", "id": "GO:0032452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032452", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "histone H3K27me2/H3K27me3 demethylase activity", "id": "GO:0071558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071558", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "histone H3K9me/H3K9me2 demethylase activity", "id": "GO:0140683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140683", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1N542", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 651, "end_pos": 653, "annotation": "n_glycosylation_sequon" }, { "start_pos": 675, "end_pos": 677, "annotation": "n_glycosylation_sequon" }, { "start_pos": 874, "end_pos": 876, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21788", "name": "", "equation": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + formaldehyde + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N542-1" ], "evidence": [ { "id": "21788", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21788" } ] }, { "id": "60188", "name": "", "equation": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLD8-1", "E1BE97-1", "E1BFC2-1", "F1N542-1", "A0A3Q1LWW0-1", "F1MBS5-1" ], "evidence": [ { "id": "60188", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60188" } ] }, { "id": "67800", "name": "", "equation": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N542-1" ], "evidence": [ { "id": "67800", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67800" } ] }, { "id": "67804", "name": "", "equation": "N(6)-methyl-L-lysyl(20)-[histone H4] + 2-oxoglutarate + O2 = L-lysyl(20)-[histone H4] + formaldehyde + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N542-1", "F1MBS5-1", "A3KMV2-1", "A0A3Q1LWW0-1", "Q29RK4-1" ], "evidence": [ { "id": "67804", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67804" } ] }, { "id": "R-BTA-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BE97-1", "E1BFC2-1", "F1N542-1", "A0A3Q1LWW0-1" ], "evidence": [ { "id": "R-BTA-4724284", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4724284" } ] }, { "id": "R-BTA-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3N346-1", "F1N542-1", "G3N2E9-1" ], "evidence": [ { "id": "R-BTA-4754187", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4754187" } ] }, { "id": "R-BTA-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BE97-1", "E1BFC2-1", "F1N542-1", "A0A3Q1LWW0-1" ], "evidence": [ { "id": "R-BTA-5661115", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661115" } ] }, { "id": "R-BTA-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3N346-1", "F1N542-1", "G3N2E9-1" ], "evidence": [ { "id": "R-BTA-5661121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661121" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LWW0", "gene_name": "PHF8", "activity": [ { "ec_number": "1.14.11.65", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "A0A3Q1LWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW0" } ] }, { "ec_number": "1.14.11.65", "activity": "", "evidence": [ { "id": "A0A3Q1LWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW0" } ] } ] }, { "uniprot_ac": "A0AAF6DLD8", "gene_name": "HR", "activity": [ { "ec_number": "1.14.11.65", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "A0AAF6DLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLD8" } ] }, { "ec_number": "1.14.11.65", "activity": "", "evidence": [ { "id": "A0AAF6DLD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLD8" } ] } ] }, { "uniprot_ac": "A3KMV2", "gene_name": "RAD23A", "activity": [ { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "A3KMV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV2" } ] } ] }, { "uniprot_ac": "E1BE97", "gene_name": "KDM3B", "activity": [ { "ec_number": "1.14.11.65", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "E1BE97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE97" } ] }, { "ec_number": "1.14.11.65", "activity": "", "evidence": [ { "id": "E1BE97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE97" } ] } ] }, { "uniprot_ac": "E1BFC2", "gene_name": "KDM3A", "activity": [ { "ec_number": "1.14.11.65", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "E1BFC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC2" } ] }, { "ec_number": "1.14.11.65", "activity": "", "evidence": [ { "id": "E1BFC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFC2" } ] } ] }, { "uniprot_ac": "F1MBS5", "gene_name": "KDM1A", "activity": [ { "ec_number": "1.14.11.65", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "F1MBS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS5" } ] }, { "ec_number": "1.14.99.66", "activity": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2.", "evidence": [ { "id": "F1MBS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS5" } ] }, { "ec_number": "1.14.99.66", "activity": "", "evidence": [ { "id": "F1MBS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS5" } ] }, { "ec_number": "1.14.11.65", "activity": "", "evidence": [ { "id": "F1MBS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS5" } ] } ] }, { "uniprot_ac": "F1N542", "gene_name": "KDM7A", "activity": [ { "ec_number": "1.14.11.65", "activity": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ] }, { "ec_number": "1.14.11.65", "activity": "", "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542" } ] } ] }, { "uniprot_ac": "G3N2E9", "gene_name": "KDM6A", "activity": [ { "ec_number": "1.14.11.68", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "G3N2E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2E9" } ] }, { "ec_number": "1.14.11.68", "activity": "", "evidence": [ { "id": "G3N2E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2E9" } ] } ] }, { "uniprot_ac": "G3N346", "gene_name": "KDM6B", "activity": [ { "ec_number": "1.14.11.68", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "G3N346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N346" } ] }, { "ec_number": "1.14.11.68", "activity": "", "evidence": [ { "id": "G3N346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N346" } ] } ] }, { "uniprot_ac": "Q29RK4", "gene_name": "RAD23B", "activity": [ { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "Q29RK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N542-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 942, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N542-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N542" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542" }, { "id": "PS51184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "JmjC", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 386, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N542" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 88, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.11.65", "ec_name": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "1.14.11.65", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65" }, { "id": "1.14.11.65", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.11.65" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 651, "end_pos": 653 }, { "start_pos": 675, "end_pos": 677 }, { "start_pos": 874, "end_pos": 876 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N545-1", "uniprot_ac": "F1N545", "uniprot_id": "F1N545_BOVIN", "mass": { "chemical_mass": 67597.0, "monoisotopic_mass": 67597.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD13A", "type": "recommended", "evidence": [ { "id": "F1N545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 13A", "type": "synonym", "evidence": [ { "id": "F1N545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N545/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545#function" }, { "database": "UniProtKB", "id": "ARBA00024956", "url": "https://www.uniprot.org/uniprotkb/ARBA00024956#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD13A", "url": "https://www.uniprot.org/uniprotkb/F1N545", "locus": { "chromosome": "17", "start_pos": 63266230, "end_pos": 63300591, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014376", "url": "https://www.ensembl.org/id/ENSBTAG00000014376" } ] } } ], "crossref": [ { "id": "F1N545", "url": "https://alphafold.ebi.ac.uk/entry/F1N545", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014376", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014376", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511883", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CHENGLG", "url": "https://omabrowser.org/oma/group/CHENGLG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N545", "url": "https://www.orthodb.org/?gene=F1N545", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12447", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12447", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12447:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12447:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11904", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11904", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N545-1", "url": "https://www.uniprot.org/uniprotkb/F1N545-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSPRDASGDFPLHLLVWNNDYRQLEKELRDQNVEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENREGWTVLHEAVSTGDPEMVYTVLQHRDFHNTSMALEGVPELLQKILEVAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVSVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATAHNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKATLWMCEEFPLSLVEQVVPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEETVSQHVEGTQPDSASPLTNFEVDQSVFEIPESYHVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGINQAHAYDAQYERAIQESLLSSSEGLGSGTSSETSRFDSDLQLAMELSAKELEERELRLREEEAELQQVLQLSLTEK", "length": 591, "header": "tr|F1N545-1|F1N545_BOVIN Isoform 1 of Ankyrin repeat domain 13A OS=Bos taurus OX=9913 GN=ANKRD13A PE=4 SV=4 CANONICAL=F1N545-1" }, "isoforms": [ { "isoform_ac": "F1N545-1", "url": "https://www.uniprot.org/uniprotkb/F1N545/entry", "sequence": { "sequence": "MSSPRDASGDFPLHLLVWNNDYRQLEKELRDQNVEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENREGWTVLHEAVSTGDPEMVYTVLQHRDFHNTSMALEGVPELLQKILEVAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVSVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATAHNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKATLWMCEEFPLSLVEQVVPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEETVSQHVEGTQPDSASPLTNFEVDQSVFEIPESYHVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGINQAHAYDAQYERAIQESLLSSSEGLGSGTSSETSRFDSDLQLAMELSAKELEERELRLREEEAELQQVLQLSLTEK", "length": 591, "header": "tr|F1N545-1|F1N545_BOVIN Isoform 1 of Ankyrin repeat domain 13A OS=Bos taurus OX=9913 GN=ANKRD13A PE=4 SV=4 CANONICAL=F1N545-1" }, "locus": { "chromosome": "17", "start_pos": 63300392, "end_pos": 63268093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019114.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019114.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019114.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019114.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511883", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJ61-1", "protein_name": "Ankyrin repeat domain 13A", "gene_name": "ANKRD13A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSACDASRHFPLHLLVWNNDYRQLEKELRGQNVEALDPRGRSLLHLAVSLGHLESARVLLRHKADVTKENREGWTVLHEAVSTGDPEMVYTVLQHRDYHNTTMALEGVPELLRKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTEHFDLSQEMERLTLDLMKPKGREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVSVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKATLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEENISQNAEGTQLDSASPLTNFEVDQSVFEIPESYHVQDNGRNMHLQDEDYEIMQFAIQQSLLESTRSQDQLLMEALARHIPTTPSTREPSRRASSPAQKALAPAVRPAALTATCSWPWSSLPKSWRSVSFGCRRRRRSCSRSYSCHSPRSRPSRLLPTHTKQTLCLRHGGTVPHPEAAEGSCPLLYAEVPGHPGPPTTLPREGAGVLRPHLQA", "length": 648 }, "evidence": [ { "id": "F1N545", "url": "https://omabrowser.org/oma/group/F1N545/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZT30-1", "protein_name": "Ankyrin repeat domain 13A", "gene_name": "ANKRD13A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEPAGGTPRMASDAFPLHVLVWNNEYRRLDEELQDQDVDQRDPRGRTLLHLAVSLGYIESAKVLLQHKADVTKENAQGWTVLHEAISTGDPEMVHMILQHRDYQQTSRTLGGVPELLQKINETPDFYVEMKWEFTSWVPLVSRVCPSDVCRIWKSGAKLRVDITLLGFENMSWERGRRSLIFKGEDAEGWAELIEINHDDKFVTTERFEISQHMERLTLGSMTPKRREVERRLTTPIINTCLDTKSIAFERTTSGFWVWRTEKAEGVNGYEAKVYMANNVNVVTKIRTEHLTEEEKKRYKADRSPLESFLGTVEHEYGVQSAVKTTEYATSNNPTAITPEEYFDPEFDLKGRDIGRPKEVTIRTQKFKATLWMSEEFPLSLVEQVTPIIDLMARTSAHFARLRDFITLEFPPGFPVKIEIPLFHVLNARITFENVNSCRTAERTSQTVGSAQGDSGANFEVDQSVFEIPKSYHVQDDGRNIHVHDEDNEIMQFAIQQSLLESSGNKEVGAHSNGAVAYSQDFNIQYQRALQESYLTSTGNSQCSSPSEPSSFEKDLQLAMELSVREQEERERQRREEEDAELQQVLQLSLVEK", "length": 594 }, "evidence": [ { "id": "F1N545", "url": "https://omabrowser.org/oma/group/F1N545/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2BG46-1", "protein_name": "Ankyrin repeat domain-containing protein 13A", "gene_name": "ankrd13a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLSASAASVEDFSLRFPLHVLVWENDYRKLETEIQTSNIEEVDPRGRTPLHLAVSLGHLESVRVLLRHGADVAKENGKNWTVLQEAVSTGDPEMVQLVLQRRDYLKASTALGGVPELLCKIRESPDFYMEMKWEFTSWIPLVSRVCPSDVCRIWKSGACLRVDTTLLGFENMTWIRGRRSYIFRGEDNCTELMEVNHEDEVVDTERFDLSREMEDVTLDSMQPAEQEVAKRLTTSIVNTYLDTKDIAFERNAIKTFTRSILRAKSGIWGWRSDRTEVVNGYEAKVFSVNNVNVVIRTRTEHLTDEEKARIKSERNVLESLLGTVEQQIGAQGDMTMEFATATNPTAITPEEYFNPNFDLQGRDIGRPIELTIRTQKFKGTLWMSEEHPLSLVEQVTPIIDLMARTSTHFARLKDFINLRFPPGFPVKIEIPLFHVLNARITFGSVNKCSTDEPLDTKTPASTPTPTEETCDNQAAAPAGPAPLFQVSPSVFLAPAHYHHRGGYRHANPRQYNPVNHDEELLQYAIHQSLLDSSVLNSQDTWSDSDGQATQSMTNRLSDGSGSEGVLVDLSDTTPSSSGSASSPDTDLRLAMELSARAQEEEEKRRKEEEEELERILQLSLTEK", "length": 623 }, "evidence": [ { "id": "F1N545", "url": "https://omabrowser.org/oma/group/F1N545/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80UP5-1", "protein_name": "Ankyrin repeat domain-containing protein 13A", "gene_name": "Ankrd13a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSARDTSSRFPLHLLVWNNDYEQLEKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLHKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGGDNWAELMEVNHDDRVVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNVAFERTKSGFWGWRTDKAEVVNGYEAKVYSVNNVSVITRIRTEHLTEEEKKRYKEDRNPLESLLGTVEHQFGAQGDLATECATVNNPTAITPDEYFDEDFDLKDRDIGRPKELTIRTQKFKATLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLDFPPGFPVKIEIPLFHVLNARITFGNVNGCSTADESQGVEGTPAEAVSEATNFEVDQSVFEIPESYHIQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQDLSGPASNGGVSHTHSYEAQYERAIQESLLTNMEGRCPGGLSESSRFDSDLQLAMELSAKELAERELRLQEEEAELQQVLQLSLTEK", "length": 588 }, "evidence": [ { "id": "F1N545", "url": "https://omabrowser.org/oma/group/F1N545/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZ07-1", "protein_name": "Ankyrin repeat domain-containing protein 13A", "gene_name": "ANKRD13A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK", "length": 590 }, "evidence": [ { "id": "F1N545", "url": "https://omabrowser.org/oma/group/F1N545/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9M840-1", "protein_name": "Ankyrin repeat family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEDYSKYTHSPAHLAVVLRDHAALRRIVSDLPRLAKAGEVTTEAESMESESRADSVSAVIDRRDVPGRETPLHLAVRLRDPVSAEILMSAGADWSLQNENGWSALQEAVCTREEAIAMIIARHYQPLAWAKWCRRLPRIIASASRIRDFYMEITFHFESSVIPFIGRIAPSDTYRIWKRGSNLRADMTLAGFDGFKIQRSDQTFLFLGDGYSSEDGKMSLSPGSLIVLSHKEKEMTNALEGAGAQPTDAEVAHEVALMSQTNMYRPGIDVTQAELVSHLNWRRQERTEMVGNWKAKVYDMLHVMVSVKSRRVPGAMTDEELFAVDEERTAVTNGAETDGFEDVLTPEERLQLNSALQTGNSDAIEDEECEVTDQQENGALKDKKGWFGWNKKGSNTEDTKLKKGSKSAPEDGNQKGKSQKSSMVSDHANEDHGDAKKGKEKKKKKKGVAGDEVKRESEYKKGLRPVLWLTPDFPLTTDELLPLLDILANKVKAVRRLRELLTTKLPLGTFPVKLAIPIIPTVRVVVTFTKFEELQAAEEEFSTPPSSPVFHDAKSSSSENSSPSWISWMRSGKSSDNDSNRYKDEADPFLIPSDYKWIDSAEKKRRMKAKKAKSRRKKQAATKAAGASDSGTRSNHVAEE", "length": 640 }, "evidence": [ { "id": "F1N545", "url": "https://omabrowser.org/oma/group/F1N545/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-modified protein reader activity", "id": "GO:0140036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140036", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of receptor internalization", "id": "GO:0002091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002091", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" }, { "name": "regulation of receptor-mediated endocytosis", "id": "GO:0048259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048259", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" }, { "name": "negative regulation of protein localization to endosome", "id": "GO:1905667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905667", "evidence": [ { "database": "UniProtKB", "id": "F1N545", "url": "https://www.uniprot.org/uniprotkb/F1N545" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N545-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 591, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N545-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N545" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N545" }, { "id": "PF11904", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11904" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ankyrin repeat", "eco_id": "ECO_0000259", "start_pos": 157, "end_pos": 471, "start_aa": "Arg", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 234, "end_pos": 236 }, { "start_pos": 274, "end_pos": 276 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N553-1", "uniprot_ac": "F1N553", "uniprot_id": "F1N553_BOVIN", "mass": { "chemical_mass": 65825.0, "monoisotopic_mass": 65825.0 }, "refseq": {}, "gene_names": [ { "name": "KCNC1", "type": "recommended", "evidence": [ { "id": "F1N553", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily C member 1", "type": "synonym", "evidence": [ { "id": "F1N553", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N553/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNC1", "url": "https://www.uniprot.org/uniprotkb/F1N553", "locus": { "chromosome": "15", "start_pos": 34734865, "end_pos": 34779954, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005424", "url": "https://www.ensembl.org/id/ENSBTAG00000005424" } ] } } ], "crossref": [ { "id": "F1N553", "url": "https://alphafold.ebi.ac.uk/entry/F1N553", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005424", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005424", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18414", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18414", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QTQSWAL", "url": "https://omabrowser.org/oma/group/QTQSWAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N553-1", "url": "https://www.uniprot.org/uniprotkb/F1N553-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGVRKDLCKESPVIAKYMPTEAVRVT", "length": 585, "header": "tr|F1N553-1|F1N553_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily C member 1 OS=Bos taurus OX=9913 GN=KCNC1 PE=4 SV=1 CANONICAL=F1N553-1" }, "isoforms": [ { "isoform_ac": "F1N553-1", "url": "https://www.uniprot.org/uniprotkb/F1N553/entry", "sequence": { "sequence": "MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGVRKDLCKESPVIAKYMPTEAVRVT", "length": 585, "header": "tr|F1N553-1|F1N553_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily C member 1 OS=Bos taurus OX=9913 GN=KCNC1 PE=4 SV=1 CANONICAL=F1N553-1" }, "locus": { "chromosome": "15", "start_pos": 34779922, "end_pos": 34736250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007132.4", "url": "https://www.ensembl.org/id/ENSBTAT00000007132.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007132.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007132.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZS84-1", "protein_name": "Potassium voltage-gated channel subfamily C member 1", "gene_name": "KCNC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGQGDESDRIVINVGGTRHQTYRSTLRTLPGTRLAWIAEPDAHSHFDYDPRTDEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDSSAEDGDIDGTGDSGDGEEELEMTKRLALSDSPDGRSGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTETEFIGNDTQVRHYREAETEAFLTYIEGVCVVWFTFEFLMRVTFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAKPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQAITPDEGLPFTRSGTRERYGPCFLLSTGEYPCPPDGGIRKGMHLHLNTEQNVGSRLCARLNVSGPLTIHEDFIIHETAAVQRRISIKDTCFLHL", "length": 618 }, "evidence": [ { "id": "F1N553", "url": "https://omabrowser.org/oma/group/F1N553/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P15388-1", "protein_name": "Voltage-gated potassium channel KCNC1", "gene_name": "Kcnc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI", "length": 511 }, "evidence": [ { "id": "F1N553", "url": "https://omabrowser.org/oma/group/F1N553/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P17972-1", "protein_name": "Potassium voltage-gated channel protein Shaw", "gene_name": "Shaw", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSDMAFSFD", "length": 498 }, "evidence": [ { "id": "F1N553", "url": "https://omabrowser.org/oma/group/F1N553/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P25122-1", "protein_name": "Voltage-gated potassium channel KCNC1", "gene_name": "Kcnc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT", "length": 585 }, "evidence": [ { "id": "F1N553", "url": "https://omabrowser.org/oma/group/F1N553/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P48547-1", "protein_name": "Voltage-gated potassium channel KCNC1", "gene_name": "KCNC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI", "length": 511 }, "evidence": [ { "id": "F1N553", "url": "https://omabrowser.org/oma/group/F1N553/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "axolemma", "id": "GO:0030673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030673", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "neuronal cell body membrane", "id": "GO:0032809", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032809", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "dendrite membrane", "id": "GO:0032590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "F1N553", "url": "https://www.uniprot.org/uniprotkb/F1N553" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N553-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 585, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N553-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N553" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N553", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N553" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 112, "start_aa": "Glu", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 220, "end_pos": 222 }, { "start_pos": 229, "end_pos": 231 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N555-1", "uniprot_ac": "F1N555", "uniprot_id": "F1N555_BOVIN", "mass": { "chemical_mass": 79334.0, "monoisotopic_mass": 79334.0 }, "refseq": { "ac": "XP_059741969", "name": "GTPase IMAP family member 8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741969" }, "gene_names": [ { "name": "GIMAP8", "type": "recommended", "evidence": [ { "id": "F1N555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ] }, { "name": "GIMAP8", "type": "synonym", "evidence": [ { "id": "XP_059741969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741969" } ] } ], "protein_names": [ { "name": "GTPase IMAP family member 8", "type": "recommended", "evidence": [ { "id": "F1N555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N555/entry#names_and_taxonomy" } ] }, { "name": "GTPase IMAP family member 8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059741969", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741969" } ] }, { "name": "Immune-associated nucleotide-binding protein 9", "type": "synonym", "evidence": [ { "id": "F1N555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N555/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555#function" }, { "database": "UniProtKB", "id": "ARBA00056809", "url": "https://www.uniprot.org/uniprotkb/ARBA00056809#function" }, { "database": "UniProtKB", "id": "A0ABI0P2E2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2E2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIMAP8", "url": "https://www.uniprot.org/uniprotkb/F1N555", "locus": { "chromosome": "4", "start_pos": 112875017, "end_pos": 112849107, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014402", "url": "https://www.ensembl.org/id/ENSBTAG00000014402" } ] } } ], "crossref": [ { "id": "F1N555", "url": "https://alphafold.ebi.ac.uk/entry/F1N555", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014402", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014402", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01852", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01852", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531516", "url": "https://www.ncbi.nlm.nih.gov/gene/531516", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CIFREKE", "url": "https://omabrowser.org/oma/group/CIFREKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N555", "url": "https://www.orthodb.org/?gene=F1N555", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10903:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10903:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04548", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059741969", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741969", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P2E2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2E2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N555-1", "url": "https://www.uniprot.org/uniprotkb/F1N555-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAGVLEKVCLSVLFSLLLSWSLQSGLADDEKISTRSPSQESESEQGSSTMEVRLLLLGKRGAGKSATGNSILGKAVFKSRFSEQPVTRSCQRESGITQGREVVVIDTPDLFSSIDDIAFVDNIKCCLELSAPSLHALLLVVSLGNYTVEDRQTAEHIQKVFEEKARRHTIIVFTRKDEDGSLEDYVKNNTSLQDLVQCFGGQYCAFNNKASKDENDAQVKELLGKVKYLVENNGPYAVNLRDEDRSLQDSVNEDTSQHSMNEDTSQRKDHPHGSGEQHQQMTGWEPSPWPPALKVLLVGKRGVGKSAVGNSLLGKRVFETRYSEKPVTQRCMSESRIWRERQVLIIDTPDFSSSKDIEQDLVNNTYPGPHAFLLVTPLGSFNEKDDMVLSTIQRIFGDKFIEYMIILLTREEDIENPDLEKFLARSKRLKELINKCKNQYSVFNYRATEEEKQCQVDKLLQEIVSMVQQNGDKPCTFREKEPLHIILVGKSGTGKSASGNTILGSPEFHSQLKAQPVTTSCHVGRRTWNGQDVVVMDTPALCQVSRAEGDLSQLEKAVKDCRSYYKEGSTVLVLVLQLGRITTEDKKAVVDLECIFGAEVMEYMIVLFTRKEDLETGKLDDYVNNTNNKYLKNIIAKCKGRYCAFNNKETGQAREDQAKELLTMASEVIKGGGQHKHPRTWNVGKIMKNIQEKPSKLLSNLKERF", "length": 706, "header": "tr|F1N555-1|F1N555_BOVIN Isoform 1 of GTPase IMAP family member 8 OS=Bos taurus OX=9913 GN=GIMAP8 PE=3 SV=2 CANONICAL=F1N555-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P2E2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2E2/entry", "sequence": { "sequence": "MEVRLLLLGKRGAGKSATGNSILGKAVFKSRFSEQPVTRSCQRESGITQGREVVVIDTPDLFSSIDDIAFVDNIKCCLELSAPSLHALLLVVSLGNYTVEDRQTAEHIQKVFEEKARRHTIIVFTRKDEDGSLEDYVKNNTSLQDLVQCFGGQYCAFNNKASKDENDAQVKELLGKVKYLVENNGPYAVNLRDEDRSLQDSVNEDTSQHSMNEDTSQRKDHPHGSGEQHQQMTGWEPSPWPPALKVLLVGKRGVGKSAVGNSLLGKRVFETRYSEKPVTQRCMSESRIWRERQVLIIDTPDFSSSKDIEQDLVNNTYPGPHAFLLVTPLGSFNEKDDMVLSTIQRIFGDKFIEYMIILLTREEDIENPDLEKFLARSKRLKELINKCKNQYSVFNYRATEEEKQCQVDKLLQEIVSMVQQNGDKPCTFREKEPLHIILVGKSGTGKSASGNTILGSPEFHSQLKAQPVTTSCHVGRRTWNGQDVVVMDTPALCQVSRAEGDLSQLEKAVKDCRSYYKEGSTVLVLVLQLGRITTEDKKAVVDLECIFGAEVMEYMIVLFTRKEDLETGKLDDYVNNTNNKYLKNIIAKCKGRYCAFNNKETGQAREDQAKELLTMASEVIKGGGQHKHPRTWNVGKIMKNIQEKPSKLLSNLKERF", "length": 656, "header": "tr|A0ABI0P2E2-1|A0ABI0P2E2_BOVIN Computationally mapped isoform of GTPase IMAP family member 8 OS=Bos taurus OX=9913 GN=GIMAP8 PE=3 SV=1 CANONICAL=F1N555-1" }, "locus": { "chromosome": "4", "start_pos": 112874013, "end_pos": 112855266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139838.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139838.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107325.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107325.1" } ] } }, { "isoform_ac": "F1N555-1", "url": "https://www.uniprot.org/uniprotkb/F1N555/entry", "sequence": { "sequence": "MSAGVLEKVCLSVLFSLLLSWSLQSGLADDEKISTRSPSQESESEQGSSTMEVRLLLLGKRGAGKSATGNSILGKAVFKSRFSEQPVTRSCQRESGITQGREVVVIDTPDLFSSIDDIAFVDNIKCCLELSAPSLHALLLVVSLGNYTVEDRQTAEHIQKVFEEKARRHTIIVFTRKDEDGSLEDYVKNNTSLQDLVQCFGGQYCAFNNKASKDENDAQVKELLGKVKYLVENNGPYAVNLRDEDRSLQDSVNEDTSQHSMNEDTSQRKDHPHGSGEQHQQMTGWEPSPWPPALKVLLVGKRGVGKSAVGNSLLGKRVFETRYSEKPVTQRCMSESRIWRERQVLIIDTPDFSSSKDIEQDLVNNTYPGPHAFLLVTPLGSFNEKDDMVLSTIQRIFGDKFIEYMIILLTREEDIENPDLEKFLARSKRLKELINKCKNQYSVFNYRATEEEKQCQVDKLLQEIVSMVQQNGDKPCTFREKEPLHIILVGKSGTGKSASGNTILGSPEFHSQLKAQPVTTSCHVGRRTWNGQDVVVMDTPALCQVSRAEGDLSQLEKAVKDCRSYYKEGSTVLVLVLQLGRITTEDKKAVVDLECIFGAEVMEYMIVLFTRKEDLETGKLDDYVNNTNNKYLKNIIAKCKGRYCAFNNKETGQAREDQAKELLTMASEVIKGGGQHKHPRTWNVGKIMKNIQEKPSKLLSNLKERF", "length": 706, "header": "tr|F1N555-1|F1N555_BOVIN Isoform 1 of GTPase IMAP family member 8 OS=Bos taurus OX=9913 GN=GIMAP8 PE=3 SV=2 CANONICAL=F1N555-1" }, "locus": { "chromosome": "4", "start_pos": 112874013, "end_pos": 112850378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019150.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019150.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019150.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019150.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HAP6-1", "protein_name": "GTPase IMAP family member 8", "gene_name": "Gimap8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATSSHRGAAGGSQKDHRSFKTSIGQGEGPSTSRDQEDSFKGSPETSTLRLLLLGKRGAGKSATGNTILGKAKFDSKFSDHMVTKQCQSETVSLRGKQVIVIDTPDLFSSQSCAEVRSLNLQQCLKLSADGLHVLLLVTPIGHYTEEDRETIEGIQGEFGTKAYSHLIVVFTREDELGEDSLKDYIDSKSSLKVLLGNAGDRYCTFNNKADKEQREQQVTRLLDVIEQMMVGSPGPYFVPLKMEGSGVQDCGHRTTYEEGDNLCGPKKREPQIPGPNQDVEMPELRVLLMGKRGVGKSAAGNSILGKQPFKIQYSEQQVTKVFTSHSRIWNGKKLLVIDSPEISSWKSDVSEVKKHTSSGPHAFLLVIPLNSSIKSDDNMFNLVKNIFGEKFTKFTIILFTRKEDLEDQALDEFISKNSNLQELILKFEKRYTAFNYRATAEEEQRQVNRLLDQVESMVRCNDNKPCIFREKELLNIILLGSSGTGKSATGNTILGRPAFLSQLGAQPITIRSQSGRATVDGQDVVVVDTPSFSQMPGIQKDIFKLREEVKYCLSLCEEGMKIFVLVLQLGRFTQEDEAAVEQLEVMFPEGIMKYTIVLFTRKEDLGDGDLSDYTRNTKNKAFKRIVKKCKERVCAFNNKETGRNREAQVKELLTIANSLRKHYDEHSFSWMDFGHPFKTIGQQIASVFKQ", "length": 691 }, "evidence": [ { "id": "F1N555", "url": "https://omabrowser.org/oma/group/F1N555/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4KLG2-1", "protein_name": "GTPase IMAP family member 8", "gene_name": "Gimap8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSSHQGAAAGSQMEHRLCETSIGQGERPRASRGQESNFKQSQGTSTLRLLLLGKQGAGKSATGNTILGKAVFESRFSHHMVTKRCQSESVSVRGKQVIVIDTPDLFSSLGCPEVQQQNLRQCLDLLADPYVLLLVTPIGHSTEEDKKTIEGIQGVFGPQAYRHMIVVFTREDELGEDTLQNHIESKKYLKKLIENIGSQRCCAFNNKADKKQQELQVSQFLDAIEFLMMESPGTYFEPLKTENSGVQGCGTGVTYKGDNLCGSKKRQPQITGPGWDRDTPELRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEKQRVTEAFASHSRLWNQKKFLIIDSPEISSWKLDESDVKEHTFPGPHAFLLVTPLGSSLKSGDSVFSIIKRIFGEKFIKFTIILFTRKEDFEGQDLDTFTKENDALCNLIQIFEGRYAVFNYRATVEEEQSQVGKLLSQIESVVQHHNNKPCVIREKELLNIILLGRSGVGKSATGNTILGRPAFVSQLRAQPVTSRSQSGRRTLDWQDIVVVDTPSLNQMSGTEKNPAQLKKEIKQCLLQNCEEGMKVFVLVFQLGRFTQEDEAVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLYDFTNNTKNKVLKRIFKKCKGRVCAFNNKETGEDQETQVKALLTIANDLKRSYDEHSTSWMDQLKSAVGQITTVFK", "length": 688 }, "evidence": [ { "id": "F1N555", "url": "https://omabrowser.org/oma/group/F1N555/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q75N62-1", "protein_name": "GTPase IMAP family member 8", "gene_name": "Gimap8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATSSHQGAAAGSQAEHRSCEASVGQGERPSASQGQEGNFKQNQGTSTLRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVIDTPDLFSSLSCSEVRQQNLKQCLELLADDHCVLLLVTPIGHYTEEDRETIEGIWGKIGPKAYRHMIVVFTREDELDEDSLWNYIESKESLKELIKNIGSRRCCTFNNKADKKQRELQVFKLLDAIELLMMESPEPYFEPLKMESSGVQGCGNGVTYEGDTLCGSKKRQPQITGPDCDPDMPELRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEKQRVTKAFASHSRVWQGKKVLIIDSPEISSWKLDESAVKNHTFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEKFTKFTIVLFTRKEDFEDQALDKVIKENDALYNLTQKFGERYAIFNYRASVEEEQSQVGKLLSQIEKMVQCHSNKPCVIREKELLNIILLGRSGAGKSATGNTILGRSAFFSQLRAQPVTSSSQSGKRTLDWQDVVVVDTPSFIQTPGTEKDPSRLKEEIHHCLSLCEEGMKIFVLVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTKNKALKKILKKCNGRVCAFNNKETGEDQETQVKGLLKIANSLKKNYDEHSNSWVGQLKSTLGQITMAFK", "length": 688 }, "evidence": [ { "id": "F1N555", "url": "https://omabrowser.org/oma/group/F1N555/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8ND71-1", "protein_name": "GTPase IMAP family member 8", "gene_name": "GIMAP8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEQSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELSAPSLHALLLVIAIGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKPLKQLVQDYEGRYCIFNNKTNSKDEQITQVLELLRKVESLVNTNGGPYHVNFKTEGSRFQDCVNEAASQEGDKPQGPRERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHICTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFNYRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSFNQMLDVEKDPSRLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDNKALRRIFKKCGRRVCAFNNKETGQAQETQVKALLTKVNDLRKESGWSGYPHTQENVSKLIKNVQEMSQAEKLLKNLIGILQ", "length": 665 }, "evidence": [ { "id": "F1N555", "url": "https://omabrowser.org/oma/group/F1N555/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N555", "url": "https://www.uniprot.org/uniprotkb/F1N555" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N555-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 706, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N555-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N555" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N555" }, { "id": "PS51720", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51720" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AIG1-type G", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 246, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 189, "end_pos": 191 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 625, "end_pos": 627 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N566-1", "uniprot_ac": "F1N566", "uniprot_id": "F1N566_BOVIN", "mass": { "chemical_mass": 51989.0, "monoisotopic_mass": 51989.0 }, "refseq": {}, "gene_names": [ { "name": "LOC507184", "type": "recommended", "evidence": [ { "id": "F1N566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N566" } ] } ], "protein_names": [ { "name": "IF rod domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1N566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N566/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N566", "url": "https://www.uniprot.org/uniprotkb/F1N566" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC507184", "url": "https://www.uniprot.org/uniprotkb/F1N566", "locus": {} } ], "crossref": [ { "id": "F1N566", "url": "https://alphafold.ebi.ac.uk/entry/F1N566", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016166", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016166", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NELNCMI", "url": "https://omabrowser.org/oma/group/NELNCMI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N566", "url": "https://www.uniprot.org/uniprotkb/F1N566", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N566-1", "url": "https://www.uniprot.org/uniprotkb/F1N566-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCLPSPVCIPGGVRAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSICGGFRAGSCDRSFGYRSGGVSGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFHQDRECCESNLEALYEGYIQTLKREAEHVEADGRRLASQSNHIQEALEGYKKKYEEEVALRATAENEFVALKKDVDGAYLHKSELEANVEALTQETDFLRQMYEEELQVLHTHISETSVIVKMDNSRDLNMDSIVAEIQAQYDDTAGRSRAEAESWYRSKCEEIKATEEINELNCMIQRLTAKVENAKCQNSKLEAAVTQAEQQGEAALNDASCKLAGLEEALQKAKQNMASLLKEYQEVMNSKLGLDIEIATYRRLLEGCLFTLQPVFRARNVSSRGGVVCGDLSLSGSRPVTGSVCSAPCSGNLAVSTGLCAPCGQSSGNSRLLRFA", "length": 474, "header": "tr|F1N566-1|F1N566_BOVIN Isoform 1 of IF rod domain-containing protein OS=Bos taurus OX=9913 GN=LOC507184 PE=3 SV=2 CANONICAL=F1N566-1" }, "isoforms": [ { "isoform_ac": "F1N566-1", "url": "https://www.uniprot.org/uniprotkb/F1N566/entry", "sequence": { "sequence": "MSCLPSPVCIPGGVRAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSICGGFRAGSCDRSFGYRSGGVSGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFHQDRECCESNLEALYEGYIQTLKREAEHVEADGRRLASQSNHIQEALEGYKKKYEEEVALRATAENEFVALKKDVDGAYLHKSELEANVEALTQETDFLRQMYEEELQVLHTHISETSVIVKMDNSRDLNMDSIVAEIQAQYDDTAGRSRAEAESWYRSKCEEIKATEEINELNCMIQRLTAKVENAKCQNSKLEAAVTQAEQQGEAALNDASCKLAGLEEALQKAKQNMASLLKEYQEVMNSKLGLDIEIATYRRLLEGCLFTLQPVFRARNVSSRGGVVCGDLSLSGSRPVTGSVCSAPCSGNLAVSTGLCAPCGQSSGNSRLLRFA", "length": 474, "header": "tr|F1N566-1|F1N566_BOVIN Isoform 1 of IF rod domain-containing protein OS=Bos taurus OX=9913 GN=LOC507184 PE=3 SV=2 CANONICAL=F1N566-1" }, "locus": { "chromosome": "5", "start_pos": 27673132, "end_pos": 27660828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038457.4", "url": "https://www.ensembl.org/id/ENSBTAT00000038457.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038270.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038270.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "F1N566", "url": "https://www.uniprot.org/uniprotkb/F1N566" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "F1N566", "url": "https://www.uniprot.org/uniprotkb/F1N566" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "F1N566", "url": "https://www.uniprot.org/uniprotkb/F1N566" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "F1N566", "url": "https://www.uniprot.org/uniprotkb/F1N566" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N566-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 474, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N566-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N566" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N566" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 410, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 418, "end_pos": 420 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N580-1", "uniprot_ac": "F1N580", "uniprot_id": "F1N580_BOVIN", "mass": { "chemical_mass": 83480.0, "monoisotopic_mass": 83480.0 }, "refseq": { "ac": "XP_024836372", "name": "protein phosphatase 1E isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836372" }, "gene_names": [ { "name": "PPM1E", "type": "recommended", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "name": "PPM1E", "type": "synonym", "evidence": [ { "id": "XP_024836372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836372" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1E", "type": "recommended", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry#names_and_taxonomy" } ] }, { "name": "Ca(2+)/calmodulin-dependent protein kinase phosphatase N", "type": "synonym", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry#names_and_taxonomy" } ] }, { "name": "CaMKP-nucleus", "type": "synonym", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry#names_and_taxonomy" } ] }, { "name": "Partner of PIX 1", "type": "synonym", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry#names_and_taxonomy" } ] }, { "name": "Partner of PIX-alpha", "type": "synonym", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase 1E isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024836372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836372" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPM1E", "url": "https://www.uniprot.org/uniprotkb/F1N580", "locus": { "chromosome": "19", "start_pos": 9937722, "end_pos": 9720216, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010788", "url": "https://www.ensembl.org/id/ENSBTAG00000010788" } ] } } ], "crossref": [ { "id": "F1N580", "url": "https://alphafold.ebi.ac.uk/entry/F1N580", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010788", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010788", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00143", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532050", "url": "https://www.ncbi.nlm.nih.gov/gene/532050", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532050", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532050", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHLRYHY", "url": "https://omabrowser.org/oma/group/SHLRYHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N580", "url": "https://www.orthodb.org/?gene=F1N580", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13832", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13832", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13832:SF535", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13832:SF535", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00481", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00481", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836372", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836372", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N580-1", "url": "https://www.uniprot.org/uniprotkb/F1N580-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGCSPEEKTYRRFLELFLGEFRGPCGGGEPQPEPEPEESEPEPEPELVAAEAREASVEEAGEAAAAGAASEEGEHEQEREDPEPEEEAVEEEAAAAAAAAGEEAAARGQSAVPPPQPRLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQETFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEDSDWTENSFQGGQEAGGDDKESHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGSQGNVLEDPGYLDLTQIETSKPHGAQFLPPVEMFGPGAPKRANLINELIMEKKSVPSSLPEWSGAGEVLSSFNVGSTGQQVCSMGSLPPVCSRLENEQFKFLGKRVSRLSHLHYHYSKRRHGFRFNPKFYSFLSAQEPSHKTGSSLSSLIRNGKRNSMLRSSLPWRQNSWKGYSENVMRKPKKSNDPAHPELPWSFKI", "length": 755, "header": "tr|F1N580-1|F1N580_BOVIN Isoform 1 of Protein phosphatase 1E OS=Bos taurus OX=9913 GN=PPM1E PE=3 SV=2 CANONICAL=F1N580-1" }, "isoforms": [ { "isoform_ac": "F1N580-1", "url": "https://www.uniprot.org/uniprotkb/F1N580/entry", "sequence": { "sequence": "MAGCSPEEKTYRRFLELFLGEFRGPCGGGEPQPEPEPEESEPEPEPELVAAEAREASVEEAGEAAAAGAASEEGEHEQEREDPEPEEEAVEEEAAAAAAAAGEEAAARGQSAVPPPQPRLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQETFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEDSDWTENSFQGGQEAGGDDKESHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGSQGNVLEDPGYLDLTQIETSKPHGAQFLPPVEMFGPGAPKRANLINELIMEKKSVPSSLPEWSGAGEVLSSFNVGSTGQQVCSMGSLPPVCSRLENEQFKFLGKRVSRLSHLHYHYSKRRHGFRFNPKFYSFLSAQEPSHKTGSSLSSLIRNGKRNSMLRSSLPWRQNSWKGYSENVMRKPKKSNDPAHPELPWSFKI", "length": 755, "header": "tr|F1N580-1|F1N580_BOVIN Isoform 1 of Protein phosphatase 1E OS=Bos taurus OX=9913 GN=PPM1E PE=3 SV=2 CANONICAL=F1N580-1" }, "locus": { "chromosome": "19", "start_pos": 9936718, "end_pos": 9720415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014279.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014279.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014279.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014279.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532050", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532050", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AKZ7-1", "protein_name": "Protein phosphatase 1E", "gene_name": "PPM1E", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGGSGSSGGGGSAEEKNYRRFLELFLGEFRGPFGAEPAPAPPPPAADTVDTAASEEDPAAEGEAAAAEAEEGDSADPRPPTPPPPPPPLPPLPRPLSEYITEEEVEGECLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYLPKHVDNADGIIQIETVKLARLVFSKLHEICSNWVKEFPLQPKPHRYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNMVHQEMFQHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWLGDSQVMLVRKGQAVELMKPHKPDREDEKKRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGSEDYLILACDGFYDTVNPDEAVKVVADHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNAAVSVSEESDWTENSFQGGQEDNGEDKENHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSIGSGINPFDDQGYVDLTKTETSMPNSAKYLPPIQVFSPGIPKNASLINGLTVKNESPESTSSICGQSNPREYSAPVSLHAAGQSIYRVKGLTPISFGLEDELFKSLGKQVAFFHFRFCNGKRRRGARLKPKFHTPLLAREPSHREGSGLPLPVRSRGSTRLLVRHSPWWRLPRPNAYSESMFLMRRQSHCIPDAYLHQCCEM", "length": 725 }, "evidence": [ { "id": "F1N580", "url": "https://omabrowser.org/oma/group/F1N580/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LNY3-1", "protein_name": "Protein phosphatase 1E", "gene_name": "PPM1E", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGCSPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPESEPESELVAAEATEASVEESGEGAATVAATEEGEQEQEQDPEPEEAVEEEALAAAEGEEEAAAARGQSAVPPPPQPLLPPLPPLPRPLSERITLEEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYIPKEMDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLHRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLPPVEMFGPGAPKKANLINELIMEKKSVQSSLPERSGAGEFLSSFNLGSTGQQICRMESLSPVCSRLENEQFRFLGKRVSRLSHLRYHYSKRRHGFRFNPKFHSFLSAREPSHKAGTSLSSLIRSGKRNRMLRSSLPWRQSSWKGYNENMMRKLKKNDIPYPDLPWSFKI", "length": 750 }, "evidence": [ { "id": "F1N580", "url": "https://omabrowser.org/oma/group/F1N580/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80TL0-1", "protein_name": "Protein phosphatase 1E", "gene_name": "Ppm1e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPESEPEPEPEAELVAAEAAEASGEEPGEDAATVEATEEGEQDQDPEPEDEAVEEETATEGEEEEEEEAAAPGHSAVPPPPQPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHCIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQIYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESEWTENSFQGGQEDGGDDKETHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGPQINVLEDPDYLDLTQIEASKPHSTQFLPPVEMIGPGAPKKDLNELIMEERSVKSSLPERSGAGEPRVSFNLGSTGQQICRMENLSPVSSGLENEQFKSRGKTASRLYHLRHHYSKRQRGFRFNPKFYSFLSAREPSHKIGISLSSLTRSGKRNKMLRSSLPWRENSWEGYSGNVKIRKRNDIPCPDFPWSYKI", "length": 749 }, "evidence": [ { "id": "F1N580", "url": "https://omabrowser.org/oma/group/F1N580/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80Z30-1", "protein_name": "Protein phosphatase 1E", "gene_name": "Ppm1e", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPESEPEPEPEAELVAAEAAEASGEDPGEDAATVEAAEEGVQDQDPEPEEEAVEEEAAAEGEEEEEEEEAAAPGHSAVPPPQPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHCIPKETDGTEGTVEIETVKLARSVFSKLHEICCNWVKDFPLRRRPQIYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGPQINVLEDPDYLDLTQIETSKPHSTQFLPPVEMIGPGAPKKAYVNELIMEESSVTPSQPERSGAGELLVSFNLGSTGQQICRMENLSPVYSGLENEQFKSPGKRASRLYHLRHHYSKRQRGFRFNPKFYSFFSAQESSRKIGISLSSLTRSGKRNKMLRSSLPWRENSWEGYSGNMAIRKRNNISCPDLPWDYKI", "length": 750 }, "evidence": [ { "id": "F1N580", "url": "https://omabrowser.org/oma/group/F1N580/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WY54-2", "protein_name": "Protein phosphatase 1E", "gene_name": "PPM1E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPWPQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPVEMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVCSGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTGSGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE", "length": 755 }, "evidence": [ { "id": "F1N580", "url": "https://omabrowser.org/oma/group/F1N580/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "F1N580", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] } ] }, { "uniprot_ac": "A0A3Q1MV48", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] } ] }, { "uniprot_ac": "A0A3Q1N5B2", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S454", "gene_name": "LOC112441581", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] } ] }, { "uniprot_ac": "A0AAA9S745", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2KJD7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] }, { "uniprot_ac": "Q3SWW9", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.53", "activity": "O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] } ] }, { "uniprot_ac": "Q3T0E7", "gene_name": "PPP1CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] } ] }, { "uniprot_ac": "Q3ZBF9", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] } ] }, { "uniprot_ac": "Q58DC0", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N580-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 755, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N580-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N580" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" }, { "id": "PS51746", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51746" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPM-type phosphatase", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 487, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.16", "ec_name": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16" }, { "id": "3.1.3.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.16" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 393, "end_pos": 395 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 495, "end_pos": 497 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N582-1", "uniprot_ac": "F1N582", "uniprot_id": "F1N582_BOVIN", "mass": { "chemical_mass": 51652.0, "monoisotopic_mass": 51652.0 }, "refseq": {}, "gene_names": [ { "name": "ODR4", "type": "recommended", "evidence": [ { "id": "F1N582", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N582" } ] } ], "protein_names": [ { "name": "Protein odr-4 homolog", "type": "recommended", "evidence": [ { "id": "F1N582", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N582/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in the trafficking of a subset of G-protein coupled receptors.", "evidence": [ { "database": "UniProtKB", "id": "F1N582", "url": "https://www.uniprot.org/uniprotkb/F1N582#function" }, { "database": "UniProtKB", "id": "ARBA00003891", "url": "https://www.uniprot.org/uniprotkb/ARBA00003891#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N582", "url": "https://www.uniprot.org/uniprotkb/F1N582" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ODR4", "url": "https://www.uniprot.org/uniprotkb/F1N582", "locus": { "chromosome": "16", "start_pos": 67498396, "end_pos": 67461867, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011946", "url": "https://www.ensembl.org/id/ENSBTAG00000011946" } ] } } ], "crossref": [ { "id": "F1N582", "url": "https://alphafold.ebi.ac.uk/entry/F1N582", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011946", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011946", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N582", "url": "https://www.orthodb.org/?gene=F1N582", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33966:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33966:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14778", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14778", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N582", "url": "https://www.uniprot.org/uniprotkb/F1N582", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N582-1", "url": "https://www.uniprot.org/uniprotkb/F1N582-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRTYIVEETVGQYLSNINLQGKAFVSGLLIGQCSSQKDYVILATRTPPKEEQNESPTHSKAKLDNLDEEWATEHAHQVSRMLPGGLLVLGVFIITALEMGSEFQNTLRRLVFAVEKSVNKKRLWNFTEEEVSERVILHFCSSTKKIFCRTYDIHDPKSSAKPADWKYQNGLSASWLSLECTVYINIHVPLSTTSVSYTLEKNTKNGLARWAKQIENGIYLINGQVKDEDCDLLEGQKKSSRGNTQAANHSFDIRVLTQLLLNSDHRSTAMVQICSGSVNLKGAVKCRAYIHSNKPKVKDAVQAMKRDILNTVADRCEILFEDLLLNEIPEKKVMSIKLNSEKEFHILPHRVFVPIPGSTVMLCDYKFGDESAEEIRDHFLEMLDCMIQIEDLEIAEEINTACISSSMDTEASLDNTDDEQPKQPIKTTIVLKIQQNIGVIAAFAVAALAAGISFHYFSD", "length": 460, "header": "tr|F1N582-1|F1N582_BOVIN Isoform 1 of Protein odr-4 homolog OS=Bos taurus OX=9913 GN=ODR4 PE=3 SV=2 CANONICAL=F1N582-1" }, "isoforms": [ { "isoform_ac": "F1N582-1", "url": "https://www.uniprot.org/uniprotkb/F1N582/entry", "sequence": { "sequence": "MGRTYIVEETVGQYLSNINLQGKAFVSGLLIGQCSSQKDYVILATRTPPKEEQNESPTHSKAKLDNLDEEWATEHAHQVSRMLPGGLLVLGVFIITALEMGSEFQNTLRRLVFAVEKSVNKKRLWNFTEEEVSERVILHFCSSTKKIFCRTYDIHDPKSSAKPADWKYQNGLSASWLSLECTVYINIHVPLSTTSVSYTLEKNTKNGLARWAKQIENGIYLINGQVKDEDCDLLEGQKKSSRGNTQAANHSFDIRVLTQLLLNSDHRSTAMVQICSGSVNLKGAVKCRAYIHSNKPKVKDAVQAMKRDILNTVADRCEILFEDLLLNEIPEKKVMSIKLNSEKEFHILPHRVFVPIPGSTVMLCDYKFGDESAEEIRDHFLEMLDCMIQIEDLEIAEEINTACISSSMDTEASLDNTDDEQPKQPIKTTIVLKIQQNIGVIAAFAVAALAAGISFHYFSD", "length": 460, "header": "tr|F1N582-1|F1N582_BOVIN Isoform 1 of Protein odr-4 homolog OS=Bos taurus OX=9913 GN=ODR4 PE=3 SV=2 CANONICAL=F1N582-1" }, "locus": { "chromosome": "16", "start_pos": 67498154, "end_pos": 67465566, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015853.8", "url": "https://www.ensembl.org/id/ENSBTAT00000015853.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015853.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015853.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N582", "url": "https://www.uniprot.org/uniprotkb/F1N582" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "F1N582", "url": "https://www.uniprot.org/uniprotkb/F1N582" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N582-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 460, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N582-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N582" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 249, "end_pos": 251 }, { "start_pos": 54, "end_pos": 56 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N586-1", "uniprot_ac": "F1N586", "uniprot_id": "F1N586_BOVIN", "mass": { "chemical_mass": 61904.0, "monoisotopic_mass": 61904.0 }, "refseq": { "ac": "XP_024840626", "name": "B-lymphocyte antigen CD19 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840626" }, "gene_names": [ { "name": "CD19", "type": "recommended", "evidence": [ { "id": "F1N586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ] }, { "name": "CD19", "type": "synonym", "evidence": [ { "id": "XP_024840626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840626" } ] } ], "protein_names": [ { "name": "B-lymphocyte antigen CD19 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024840626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840626" } ] }, { "name": "CD19 molecule", "type": "synonym", "evidence": [ { "id": "F1N586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N586/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD19", "url": "https://www.uniprot.org/uniprotkb/F1N586", "locus": { "chromosome": "25", "start_pos": 25905404, "end_pos": 25911804, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032122", "url": "https://www.ensembl.org/id/ENSBTAG00000032122" } ] } } ], "crossref": [ { "id": "F1N586", "url": "https://alphafold.ebi.ac.uk/entry/F1N586", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032122", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032122", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23999", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23999", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517359", "url": "https://www.ncbi.nlm.nih.gov/gene/517359", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ENMENPE", "url": "https://omabrowser.org/oma/group/ENMENPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N586", "url": "https://www.orthodb.org/?gene=F1N586", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16674", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16674", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16674:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16674:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-1257604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-977606", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024840626", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840626", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N586-1", "url": "https://www.uniprot.org/uniprotkb/F1N586-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPPLLFLLLFLTPVGVRPEDPRLVEAKEGGDAVLPCLEGSSAGPPEQLAWFRGSQTTPFLNLSLGLPGLGIHVGPLGTLKEPQGTLLFLFNVSKHMGGFYLCQPGLSSEQGWQPGWTVSVQGSGKLFRWNASDLNDPSCDLRNKTSKGPRSSSGHPTKSQLNVWGTDHFKEISHADLPCAPPNSTLNHSDNRDLTVAPGSTLLLSCGASHTSLVRGSVSWIHKYPMKPEVKLLSLYVSKHAQLREMWVMGTLGGKVVLLLPEATAQDADIYRCNHGNKTTQMQLKVTAQSVWHWLLETGVWKVPVVTLIYLIFCLTSLVGFLYLRRALILRRKRKRMTDPNRRFFKVTPPPGNGANSQYGNMLSLSMPHSGTGRALRWAAGLGAAAPSYGNPRSDVQEARAAGSRSPPGPGPEEEEGEAYEEPDSEEGSEFYENDSNLGQDQLSQDGSGYENPEEGSLDPQDEDSFSNGAESYENEDEELAPTVTRTTDLLSPHGSAWDPSREAASLGSQSYEDMRGILYAAPQLRFVRAQPGANHEEDADSYENMDNPDGPEPAWGGGARIGWSTR", "length": 568, "header": "tr|F1N586-1|F1N586_BOVIN Isoform 1 of CD19 molecule OS=Bos taurus OX=9913 GN=CD19 PE=4 SV=3 CANONICAL=F1N586-1" }, "isoforms": [ { "isoform_ac": "F1N586-1", "url": "https://www.uniprot.org/uniprotkb/F1N586/entry", "sequence": { "sequence": "MPPPLLFLLLFLTPVGVRPEDPRLVEAKEGGDAVLPCLEGSSAGPPEQLAWFRGSQTTPFLNLSLGLPGLGIHVGPLGTLKEPQGTLLFLFNVSKHMGGFYLCQPGLSSEQGWQPGWTVSVQGSGKLFRWNASDLNDPSCDLRNKTSKGPRSSSGHPTKSQLNVWGTDHFKEISHADLPCAPPNSTLNHSDNRDLTVAPGSTLLLSCGASHTSLVRGSVSWIHKYPMKPEVKLLSLYVSKHAQLREMWVMGTLGGKVVLLLPEATAQDADIYRCNHGNKTTQMQLKVTAQSVWHWLLETGVWKVPVVTLIYLIFCLTSLVGFLYLRRALILRRKRKRMTDPNRRFFKVTPPPGNGANSQYGNMLSLSMPHSGTGRALRWAAGLGAAAPSYGNPRSDVQEARAAGSRSPPGPGPEEEEGEAYEEPDSEEGSEFYENDSNLGQDQLSQDGSGYENPEEGSLDPQDEDSFSNGAESYENEDEELAPTVTRTTDLLSPHGSAWDPSREAASLGSQSYEDMRGILYAAPQLRFVRAQPGANHEEDADSYENMDNPDGPEPAWGGGARIGWSTR", "length": 568, "header": "tr|F1N586-1|F1N586_BOVIN Isoform 1 of CD19 molecule OS=Bos taurus OX=9913 GN=CD19 PE=4 SV=3 CANONICAL=F1N586-1" }, "locus": { "chromosome": "25", "start_pos": 25911767, "end_pos": 25905719, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008598.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008598.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008598.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008598.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1257604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-BTA-198933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-977606", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "resource": "Reactome", "description": "Regulation of Complement cascade" }, { "id": "R-BTA-983695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983695", "resource": "Reactome", "description": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UGD5-1", "protein_name": "CD19 molecule", "gene_name": "CD19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPPPLLLFSLLFSFFFLTPVEARPQEPYLVEAQEGGNAVLPCLEGPSEGPPEQLAWFRGSQSTPFLELSLGLPGLGIHVGPLGTLKEPQGTLLFIFNVSDQMGGFYLCQQGPPLDQSWQPGWTVNVKGSGELFRWNASDLNDPSCDLGARSSEGRRSSSSHPTRSKLYVWAKNQAKVLHTDLTCPPPNSTVNQSNSHDLTVAPGSTLSLSCGSSRASLVRGPISWIHVRPKKHVKLLSLNLTEDAQLREMWVMGSLRGKAVLLLPEATAQDADTYHCNHGNVTTQMRLKVTARSVWHWLLETGGWQVPVVTLVYLIFCLGSLVGFLHLRRALILRRKRKRMTDPTRRFFKVTPPPGNGAQNQYGNVLSLSTPHSGTGRALRWAAGLGAAVPSYGNPRSDVQEARAAGSRSPPGTGPEEEEGEAYEEPDSEEGSEFYENDSNLGRDQLSQDGSNYENPEEGVLGPEDEDSFSNAAESYENEDEELVQPVARTTDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSFRGQPGPNHEEDADSYENMDNPDGPEPAWGGGGHMGAWSTR", "length": 572 }, "evidence": [ { "id": "F1N586", "url": "https://omabrowser.org/oma/group/F1N586/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1LNH2-1", "protein_name": "CD19 molecule", "gene_name": "Cd19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWGLPQPSQTPMVHCPLGSCLPQHPLRSRAEAGCPREPGYHAISSPCLPPPLPYLSRRQAPEFLTGGGRRGWGSPFPLPTEGDNVVLSCLRDSSPVSSEKLAWYRGNQSTPFLELSLRSPDLGLHIGPLGILLVIVNVSDHRGGFYLCQKRPSFKDTWQPAWTVNVEDSGELFRWNASDLGDLDCDLGNRSSGSHRSTSGSQLYVWATDHPEVWKTKPVCAPREISLNQSLINQDLTVAPGSTLWLSCGVPPVPVTKGSISWTHVHPKTLNVSLLSLSLGGEHPVREMWVWGSLLLLPQAKASDEGTYYCLQGGLTIKMHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSMAAFLYFRRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAASLGSGPVSYGNPRIEVQDAGAQRHETGLEEEGEAYEEPDSEEGSEFYENDSNLEQDQLSQDGSGYENPEDDPVGPEEEDSFSNAESYENADEELAQPVGRTMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLQSIRSGPSHEEDADSYENMDKSDDPEPAWAGEGHMGTWGAT", "length": 598 }, "evidence": [ { "id": "F1N586", "url": "https://omabrowser.org/oma/group/F1N586/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P15391-1", "protein_name": "B-lymphocyte antigen CD19", "gene_name": "CD19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR", "length": 556 }, "evidence": [ { "id": "F1N586", "url": "https://omabrowser.org/oma/group/F1N586/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P25918-1", "protein_name": "B-lymphocyte antigen CD19", "gene_name": "Cd19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSPLPVSFLLFLTLVGGRPQKSLLVEVEEGGNVVLPCLPDSSPVSSEKLAWYRGNQSTPFLELSPGSPGLGLHVGSLGILLVIVNVSDHMGGFYLCQKRPPFKDIWQPAWTVNVEDSGEMFRWNASDVRDLDCDLRNRSSGSHRSTSGSQLYVWAKDHPKVWGTKPVCAPRGSSLNQSLINQDLTVAPGSTLWLSCGVPPVPVAKGSISWTHVHPRRPNVSLLSLSLGGEHPVREMWVWGSLLLLPQATALDEGTYYCLRGNLTIERHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSLVAFLYCQRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAAGLGSVPGSYGNPRIQVQDTGAQSHETGLEEEGEAYEEPDSEEGSEFYENDSNLGQDQVSQDGSGYENPEDEPMGPEEEDSFSNAESYENADEELAQPVGRMMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLHSIQSGPSHEEDADSYENMDKSDDLEPAWEGEGHMGTWGTT", "length": 547 }, "evidence": [ { "id": "F1N586", "url": "https://omabrowser.org/oma/group/F1N586/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "B cell proliferation involved in immune response", "id": "GO:0002322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002322", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "positive regulation of release of sequestered calcium ion into cytosol", "id": "GO:0051281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051281", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "immunoglobulin mediated immune response", "id": "GO:0016064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016064", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "regulation of B cell receptor signaling pathway", "id": "GO:0050855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050855", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "regulation of B cell activation", "id": "GO:0050864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050864", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "B-1 B cell differentiation", "id": "GO:0001923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001923", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1N586", "url": "https://www.uniprot.org/uniprotkb/F1N586" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N586-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 568, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N586-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N586" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N586" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 104, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 144, "end_pos": 146 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 435, "end_pos": 437 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N587-1", "uniprot_ac": "F1N587", "uniprot_id": "F1N587_BOVIN", "mass": { "chemical_mass": 91488.0, "monoisotopic_mass": 91488.0 }, "refseq": {}, "gene_names": [ { "name": "CPT1C", "type": "recommended", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] } ], "protein_names": [ { "name": "Palmitoyl thioesterase CPT1C", "type": "recommended", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587/entry#names_and_taxonomy" } ] }, { "name": "3.1.2.22", "type": "synonym", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587/entry#names_and_taxonomy" } ] }, { "name": "Carnitine O-palmitoyltransferase 1, brain isoform", "type": "synonym", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587/entry#names_and_taxonomy" } ] }, { "name": "Carnitine palmitoyltransferase 1C", "type": "synonym", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587/entry#names_and_taxonomy" } ] }, { "name": "Carnitine palmitoyltransferase I", "type": "synonym", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels.", "evidence": [ { "database": "UniProtKB", "id": "A0ABI0P5H4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5H4#function" }, { "database": "UniProtKB", "id": "ARBA00058912", "url": "https://www.uniprot.org/uniprotkb/ARBA00058912#function" }, { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPT1C", "url": "https://www.uniprot.org/uniprotkb/F1N587", "locus": { "chromosome": "18", "start_pos": 56112165, "end_pos": 56092333, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012205", "url": "https://www.ensembl.org/id/ENSBTAG00000012205" } ] } } ], "crossref": [ { "id": "F1N587", "url": "https://alphafold.ebi.ac.uk/entry/F1N587", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012205", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012205", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513710", "url": "https://www.ncbi.nlm.nih.gov/gene/513710", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513710", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513710", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N587", "url": "https://www.orthodb.org/?gene=F1N587", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22589", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22589", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22589:SF55", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22589:SF55", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00755", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00755", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16484", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16484", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19233", "url": "https://www.rhea-db.org/rhea/19233", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0ABI0P5H4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5H4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N587-1", "url": "https://www.uniprot.org/uniprotkb/F1N587-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAHQAVGFRPSLTSDAGEVELGVPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFLFSAIQLACFLQLDPSLGLMEKIKESLPDWGGQHHRLRGVLAAALFASCLWGALIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPVLSDKDFDWTAGLAQEFLKLQASLLQWYLQLKSWWASNYVSDWWEEFVYLRSRNSLMVNSNYYMMDFLYVTPTPVQAARAGNAVHALLLYRHRLDRQEILPTLLMGMRPLCSAQYEKIFNTTRIPGVHRDHIRHLRDSRHVAVFHRGRFFRVGTHSQSRLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRDTWAQVRRSLKTQAQEALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGQGHDRWFDKSFSLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSADGHCKGHPDPLLPQPQRLHWDLPDKIHLSISLALRAAKTLSGNIDCHVFPFSHFGKNFIKRCHLSSDSFIQTTLQLAHFRDRGQFCLTYESTMTRLFLEGRTETVRSCTREARDFVRAMEDKEKTDAQCLALFRLAVDKHQALLKAAMSGQGVDRHLFALYIVSQFLHLQSPFLDQVHSEQWQLATSQIPVQQIHLFDVRNYPDYVSSGGGFGPADDHGYGVSYMFMGDDVITFHISSKKSSTRTVRLTHPGPSSLGTSASLLSYSSGFQTPSLPPAHDPGAPVLKPRSPQAQGQGPQPSCFSASRNPSPSFSCT", "length": 812, "header": "tr|F1N587-1|F1N587_BOVIN Isoform 1 of Palmitoyl thioesterase CPT1C OS=Bos taurus OX=9913 GN=CPT1C PE=3 SV=5 CANONICAL=F1N587-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P5H4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5H4/entry", "sequence": { "sequence": "MAEAHQAVGFRPSLTSDAGEVELGVPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFLFSAIQLACFLQLDPSLGLMEKIKESLPDWGGQHHRLRGVLAAALFASCLWGALIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPVLSDKDFDWTAGLAQEFLKLQASLLQWYLQLKSWWASNYVSDWWEEFVYLRSRNSLMVNSNYYMMDFLYVTPTPVQAARAGNAVHALLLYRHRLDRQEILPTLLMGMRPLCSAQYEKIFNTTRIPGVHRDHIRHLRDSRHVAVFHRGRFFRVGTHSQSRLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRDTWAQVRRSLKTQAQEALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGQGHDRWFDKSFSLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSADGHCKGHPDPLLPQPQRLHWDLPDKIHLSISLALRAAKTLSGNIDCHVFPFSHFGKNFIKRCHLSSDSFIQTTLQLAHFRDRGQFCLTYESTMTRLFLEGRTETVRSCTREARDFVRAMEDKEKTDAQCLALFRLAVDKHQALLKAAMSGQGVDRHLFALYIVSQFLHLQSPFLDQVHSEQWQLATSQIPVQQIHLFDVRNYPDYVSSGGGFGPADDHGYGVSYMFMGDDVITFHISSKKSSTRTDSHRLGQRIQDALLDVAALFPEGQRLKRRGLGEEDSG", "length": 779, "header": "tr|A0ABI0P5H4-1|A0ABI0P5H4_BOVIN Computationally mapped isoform of Palmitoyl thioesterase CPT1C OS=Bos taurus OX=9913 GN=CPT1C PE=3 SV=1 CANONICAL=F1N587-1" }, "locus": { "chromosome": "18", "start_pos": 56111192, "end_pos": 56093245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146181.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146181.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106288.1" } ] } }, { "isoform_ac": "F1N587-1", "url": "https://www.uniprot.org/uniprotkb/F1N587/entry", "sequence": { "sequence": "MAEAHQAVGFRPSLTSDAGEVELGVPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFLFSAIQLACFLQLDPSLGLMEKIKESLPDWGGQHHRLRGVLAAALFASCLWGALIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPVLSDKDFDWTAGLAQEFLKLQASLLQWYLQLKSWWASNYVSDWWEEFVYLRSRNSLMVNSNYYMMDFLYVTPTPVQAARAGNAVHALLLYRHRLDRQEILPTLLMGMRPLCSAQYEKIFNTTRIPGVHRDHIRHLRDSRHVAVFHRGRFFRVGTHSQSRLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRDTWAQVRRSLKTQAQEALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGQGHDRWFDKSFSLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSADGHCKGHPDPLLPQPQRLHWDLPDKIHLSISLALRAAKTLSGNIDCHVFPFSHFGKNFIKRCHLSSDSFIQTTLQLAHFRDRGQFCLTYESTMTRLFLEGRTETVRSCTREARDFVRAMEDKEKTDAQCLALFRLAVDKHQALLKAAMSGQGVDRHLFALYIVSQFLHLQSPFLDQVHSEQWQLATSQIPVQQIHLFDVRNYPDYVSSGGGFGPADDHGYGVSYMFMGDDVITFHISSKKSSTRTVRLTHPGPSSLGTSASLLSYSSGFQTPSLPPAHDPGAPVLKPRSPQAQGQGPQPSCFSASRNPSPSFSCT", "length": 812, "header": "tr|F1N587-1|F1N587_BOVIN Isoform 1 of Palmitoyl thioesterase CPT1C OS=Bos taurus OX=9913 GN=CPT1C PE=3 SV=5 CANONICAL=F1N587-1" }, "locus": { "chromosome": "18", "start_pos": 56111061, "end_pos": 56093245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016188.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016188.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016188.8", "url": "https://www.ensembl.org/id/ENSBTAP00000016188.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 265, "start_aa": "Thr", "end_pos": 265, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr265", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513710", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513710", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "AMPA glutamate receptor complex", "id": "GO:0032281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032281", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "regulation of postsynaptic membrane neurotransmitter receptor levels", "id": "GO:0099072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099072", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "F1N587", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19233", "name": "", "equation": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T2L1-1", "A0AAA9SCF5-1", "A0AAA9SFH2-1", "A0A3Q1M5Z8-1", "G3MWX2-1", "A0AAF6YMI2-1", "A5PKD9-1", "P45478-1", "Q3MHR0-1", "Q1ZYR0-1", "Q5E9H9-1", "F1MNH5-1", "Q2HJ19-1", "A0AAA9S0E0-1", "F1MYM8-1", "F6RC73-1", "F1N587-1" ], "evidence": [ { "id": "19233", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19233" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M5Z8", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] } ] }, { "uniprot_ac": "A0AAA9S0E0", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] } ] }, { "uniprot_ac": "A0AAA9SCF5", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] } ] }, { "uniprot_ac": "A0AAA9SFH2", "gene_name": "DESI1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] } ] }, { "uniprot_ac": "A0AAA9T2L1", "gene_name": "ABHD17B", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ] } ] }, { "uniprot_ac": "A0AAF6YMI2", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.1.93", "activity": "mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+).", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.1.93", "activity": "", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] } ] }, { "uniprot_ac": "A5PKD9", "gene_name": "ABHD17C", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A5PKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKD9" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A5PKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKD9" } ] } ] }, { "uniprot_ac": "F1MNH5", "gene_name": "DESI2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] } ] }, { "uniprot_ac": "F1MYM8", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1MYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1MYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM8" } ] } ] }, { "uniprot_ac": "F1N587", "gene_name": "CPT1C", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] } ] }, { "uniprot_ac": "F6RC73", "gene_name": "LYPLAL1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F6RC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RC73" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F6RC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RC73" } ] } ] }, { "uniprot_ac": "G3MWX2", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] } ] }, { "uniprot_ac": "P45478", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] } ] }, { "uniprot_ac": "Q1ZYR0", "gene_name": "CLN5", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] } ] }, { "uniprot_ac": "Q2HJ19", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q2HJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ19" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q2HJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ19" } ] } ] }, { "uniprot_ac": "Q3MHR0", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] } ] }, { "uniprot_ac": "Q5E9H9", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] }, { "ec_number": "3.1.1.93", "activity": "mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+).", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N587-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 812, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N587-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N587" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" }, { "id": "PF16484", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16484" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carnitine O-palmitoyltransferase N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 47, "start_aa": "Met", "end_aa": "Trp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" }, { "id": "PF00755", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00755" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Choline/carnitine acyltransferase", "eco_id": "ECO_0000259", "start_pos": 175, "end_pos": 743, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.22", "ec_name": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "3.1.2.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22" }, { "id": "3.1.2.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 265 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 312, "end_pos": 314 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N596-1", "uniprot_ac": "F1N596", "uniprot_id": "F1N596_BOVIN", "mass": { "chemical_mass": 57202.0, "monoisotopic_mass": 57202.0 }, "refseq": { "ac": "XP_005202724", "name": "dual specificity protein kinase CLK1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202724" }, "gene_names": [ { "name": "CLK1", "type": "recommended", "evidence": [ { "id": "F1N596", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ] }, { "name": "CLK1", "type": "synonym", "evidence": [ { "id": "XP_005202724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202724" } ] } ], "protein_names": [ { "name": "dual-specificity kinase", "type": "recommended", "evidence": [ { "id": "F1N596", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N596/entry#names_and_taxonomy" } ] }, { "name": "2.7.12.1", "type": "synonym", "evidence": [ { "id": "F1N596", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N596/entry#names_and_taxonomy" } ] }, { "name": "dual specificity protein kinase CLK1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202724" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLK1", "url": "https://www.uniprot.org/uniprotkb/F1N596", "locus": { "chromosome": "2", "start_pos": 89504941, "end_pos": 89512175, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005408", "url": "https://www.ensembl.org/id/ENSBTAG00000005408" } ] } } ], "crossref": [ { "id": "F1N596", "url": "https://alphafold.ebi.ac.uk/entry/F1N596", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005408", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005408", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613808", "url": "https://www.ncbi.nlm.nih.gov/gene/613808", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HENGYHN", "url": "https://omabrowser.org/oma/group/HENGYHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N596", "url": "https://www.orthodb.org/?gene=F1N596", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45646", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45646", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45646:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45646:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005202724", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N596-1", "url": "https://www.uniprot.org/uniprotkb/F1N596-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRHSKRSYCPDWDEKDWDYGKWKSSSGSHKRKKRSHSSARENKRCRYNYSKTSDSYYLESRSLNEKDYHSRRYIDEYRNDYSQGCEPGHRHKDYESRYQNHSSKSSGRSGRSSYKSKHRIHDSTSYHCSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPSSTFRCVQMLEWFEHHGHVCIVFELLGLSTYDFIKENGFLPFRLDHIRRMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKMKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIQKMLEYEPAKRITLKEALKHPFFYPLKKAT", "length": 485, "header": "tr|F1N596-1|F1N596_BOVIN Isoform 1 of dual-specificity kinase OS=Bos taurus OX=9913 GN=CLK1 PE=3 SV=1 CANONICAL=F1N596-1" }, "isoforms": [ { "isoform_ac": "F1N596-1", "url": "https://www.uniprot.org/uniprotkb/F1N596/entry", "sequence": { "sequence": "MRHSKRSYCPDWDEKDWDYGKWKSSSGSHKRKKRSHSSARENKRCRYNYSKTSDSYYLESRSLNEKDYHSRRYIDEYRNDYSQGCEPGHRHKDYESRYQNHSSKSSGRSGRSSYKSKHRIHDSTSYHCSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPSSTFRCVQMLEWFEHHGHVCIVFELLGLSTYDFIKENGFLPFRLDHIRRMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKMKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIQKMLEYEPAKRITLKEALKHPFFYPLKKAT", "length": 485, "header": "tr|F1N596-1|F1N596_BOVIN Isoform 1 of dual-specificity kinase OS=Bos taurus OX=9913 GN=CLK1 PE=3 SV=1 CANONICAL=F1N596-1" }, "locus": { "chromosome": "2", "start_pos": 89511171, "end_pos": 89505168, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007115.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007115.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007115.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007115.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MKX4-1", "protein_name": "dual-specificity kinase", "gene_name": "Clk1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRHLKRTYCPDWDERDWDYGTWRNSSSHKRKKRSHSSIREHKRCKYNHSKTTDSYYLGSRSIHEREYHSRRYIDEYRNDDMGYEPGYYYYGEHESRYQNHSSKSSGRSGRSSYKSNHRTHHRTSHHRSLGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVNTLGEGAFGKVVECIDHKMGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICRSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKMKRDERTVINPDVKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDTEHELLFDLIGKMLAYDPAERITLREALKHPFFNPLKKHSL", "length": 485 }, "evidence": [ { "id": "F1N596", "url": "https://omabrowser.org/oma/group/F1N596/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4ADG3-1", "protein_name": "dual-specificity kinase", "gene_name": "Clk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRHSKRTYCPDWDERDWDYGTWRSSSSHKRRKRSHSSARDYKRCKYNHSKTTDSYYLESRSIHEKAYHSRRYVDEYRNDYMTYEPGYPYGEPGSRYQNHSSKSSGRSGRSSYKSKHRSHHHTSHRRSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRHVAVKIVKNVDRYCEAAQSEIQVLEHLNATDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIEKTRKRTYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT", "length": 483 }, "evidence": [ { "id": "F1N596", "url": "https://omabrowser.org/oma/group/F1N596/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P22518-1", "protein_name": "Dual specificity protein kinase CLK1", "gene_name": "Clk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT", "length": 483 }, "evidence": [ { "id": "F1N596", "url": "https://omabrowser.org/oma/group/F1N596/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P49759-1", "protein_name": "Dual specificity protein kinase CLK1", "gene_name": "CLK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI", "length": 484 }, "evidence": [ { "id": "F1N596", "url": "https://omabrowser.org/oma/group/F1N596/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" }, { "name": "protein serine/threonine/tyrosine kinase activity", "id": "GO:0004712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004712", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "F1N596", "url": "https://www.uniprot.org/uniprotkb/F1N596" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N596-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 485, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N596-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N596" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N596", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N596" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 162, "end_pos": 478, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.12.1", "ec_name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.12.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1" }, { "id": "2.7.12.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.12.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5B5-1", "uniprot_ac": "F1N5B5", "uniprot_id": "F1N5B5_BOVIN", "mass": { "chemical_mass": 44746.0, "monoisotopic_mass": 44746.0 }, "refseq": { "ac": "XP_002691669", "name": "RNA exonuclease 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691669" }, "gene_names": [ { "name": "REXO4", "type": "recommended", "evidence": [ { "id": "F1N5B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ] }, { "name": "REXO4", "type": "synonym", "evidence": [ { "id": "XP_002691669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691669" } ] } ], "protein_names": [ { "name": "RNA exonuclease 4", "type": "recommended", "evidence": [ { "id": "F1N5B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5B5/entry#names_and_taxonomy" } ] }, { "name": "RNA exonuclease 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002691669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691669" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REXO4", "url": "https://www.uniprot.org/uniprotkb/F1N5B5", "locus": { "chromosome": "11", "start_pos": 104302961, "end_pos": 104312129, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019721", "url": "https://www.ensembl.org/id/ENSBTAG00000019721" } ] } } ], "crossref": [ { "id": "F1N5B5", "url": "https://alphafold.ebi.ac.uk/entry/F1N5B5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019721", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06144", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06144", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140713", "url": "https://www.ncbi.nlm.nih.gov/gene/100140713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIKPTEP", "url": "https://omabrowser.org/oma/group/YIKPTEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N5B5", "url": "https://www.orthodb.org/?gene=F1N5B5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12801", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12801", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12801:SF158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12801:SF158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00929", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00929", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691669", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691669", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5B5-1", "url": "https://www.uniprot.org/uniprotkb/F1N5B5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKARGPAAGRAPRGPAPDAGPVRKPRRKKRVRKNKAREAGGTPGVDPGVVAVRPPKAPEDFSPNWKALQELLKQRSRTPQEPPLLSQTDSKKQPQRVQQNRNSISDKAKTDAMGTENTDPEVTGASGPSGSLMSRKIQAQPKEKGAQKRTNGDISPQQGDIKHKKRKAREPTAPSPPAPPTKDDIWFDDVDPADIEAAIGPEAASIARQQLGQSESSSTLVKERPFGGLTKALAMDCEMVGVGPEGEESVVARVSLVNQHGRCVYDKHVKPTQPVTDYRTAVSGVRPADLAQGEEFEVVQREVAELLKGRILVGHALHNDLKALFLGHPKKKIRDTQKYKPFRTQVKSGRPSLKLLAERILGIQVQQAEHCSVQDAQVAMRLYVLVKRDWESLAGDRRPPAPEAHSQDA", "length": 410, "header": "tr|F1N5B5-1|F1N5B5_BOVIN Isoform 1 of RNA exonuclease 4 OS=Bos taurus OX=9913 GN=REXO4 PE=3 SV=3 CANONICAL=F1N5B5-1" }, "isoforms": [ { "isoform_ac": "F1N5B5-1", "url": "https://www.uniprot.org/uniprotkb/F1N5B5/entry", "sequence": { "sequence": "MVKARGPAAGRAPRGPAPDAGPVRKPRRKKRVRKNKAREAGGTPGVDPGVVAVRPPKAPEDFSPNWKALQELLKQRSRTPQEPPLLSQTDSKKQPQRVQQNRNSISDKAKTDAMGTENTDPEVTGASGPSGSLMSRKIQAQPKEKGAQKRTNGDISPQQGDIKHKKRKAREPTAPSPPAPPTKDDIWFDDVDPADIEAAIGPEAASIARQQLGQSESSSTLVKERPFGGLTKALAMDCEMVGVGPEGEESVVARVSLVNQHGRCVYDKHVKPTQPVTDYRTAVSGVRPADLAQGEEFEVVQREVAELLKGRILVGHALHNDLKALFLGHPKKKIRDTQKYKPFRTQVKSGRPSLKLLAERILGIQVQQAEHCSVQDAQVAMRLYVLVKRDWESLAGDRRPPAPEAHSQDA", "length": 410, "header": "tr|F1N5B5-1|F1N5B5_BOVIN Isoform 1 of RNA exonuclease 4 OS=Bos taurus OX=9913 GN=REXO4 PE=3 SV=3 CANONICAL=F1N5B5-1" }, "locus": { "chromosome": "11", "start_pos": 104311930, "end_pos": 104303965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026283.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026283.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026283.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026283.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 43, "start_aa": "Thr", "end_pos": 43, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100140713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140713", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AHV0-1", "protein_name": "RNA exonuclease 4", "gene_name": "REXO4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAKADPEAAARGKGRRRRVRRGPGQHAGTAAQKGQKAAAVAALPRSPQEFSSNWKALQELLKQKASTSNEPLPSAQTNTKKQHLLKEGNSQQVPAGTGDENVLKPKSTNKKDRGPTAHSPPLAKVKSKKAATDKNSKPKHTDKRAKSCADGSTPMAGPKPRKAEEDKNWNGTKSDGKSCKEKRKNGNIEKEKSDVKHKKRKAEAAVQQPKEADIWFDDVDPKDIEAAIGPEAAEVARRKLGLEAGQSKQSVEQVLVKEKSSGGLTRAVAMDCEMVGVGPSGEDSIVARVSIVNLFGKCIYDKYVKPTEEVTDYRTAVSGIRPEHLKTGEDFKTVQKEVADILNGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFRQRVKNARPSLKLLCDRLLDVQVQTSEHCSIQDAQAAMRLYTLEKKEWEAALKNKSKRQTVKLE", "length": 441 }, "evidence": [ { "id": "F1N5B5", "url": "https://omabrowser.org/oma/group/F1N5B5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7ESM1-1", "protein_name": "RNA exonuclease 4", "gene_name": "Rexo4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "YASAVTRVSSLLARAAESEKMKTKATAPVPQPGPIRKLVRKKAKKKFKKSKALGGSGTPGSRPATVASRPPKAPENFSQNWKALQELLKRKSEAPEKPRISQLDDKIHHQIIQKNRKKTSDKSKGDKRTEDDKPTRDSVTSAPKKVRKTPVPPTNASGTEQKKGAEKRTRSDLSSHQGDIKHKGKAKEAAVILSQPTPTEEDIWFDDVDPDDIEAAVGPEAAMLVRKRLGQRTSTISLVKEQAFGGLTKALALDCEMVGVGPKGEESIAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEEFEVVKKEVAAMLKGRILVGHALRNDLKVLFLEHPKKKIRDTQKFKPFRSLVKSARPSLKQLSEKILGLRVQQAEHCSVQDAQAAMRLYIMVKRKWESIAADRRAPAATPHHCNEYA", "length": 429 }, "evidence": [ { "id": "F1N5B5", "url": "https://omabrowser.org/oma/group/F1N5B5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3L751-1", "protein_name": "RNA exonuclease 4", "gene_name": "REXO4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKARMLAPERAPGDPAPEPGLVKKPSRKKNRKKRFWKNKAREASTKPGNDPRGVAVRPPKAPEDFSQNWKVLRELLKPKSQALEESLVPSRLNSRKQPQRAQPSRKAVPDRAERSEVGTENTAPEASGGAAPSPRLPTQRKRPAPRTQAGGRAQHREKEAKTRTSGDISPKRGDVKHKKRKAKEVTAPLPPAAPTEADIWFDDVDPADIEAALGPEAAQVARKQLGQSESGVTLVKERAFDGLTRALALDCEMVGVGPQGDESMLARVSLVNQFGKCVYDKYVKPTQPVTDYRTAVSGIRPENLAQGEEFEIVQKEVAALLKGRILVGHALHNDLKVLFLGHPKKKVRDTQKYRPFRSQVKSGRPSLKLLAEKILGLPVQQAEHCSVQDAQAAMRLYISVKREWESLARDRHPSAPALDARSHRT", "length": 426 }, "evidence": [ { "id": "F1N5B5", "url": "https://omabrowser.org/oma/group/F1N5B5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9GZR2-1", "protein_name": "RNA exonuclease 4", "gene_name": "REXO4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGLTRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSDDA", "length": 422 }, "evidence": [ { "id": "F1N5B5", "url": "https://omabrowser.org/oma/group/F1N5B5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "DNA catabolic process", "id": "GO:0006308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006308", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "3'-5' exonuclease activity", "id": "GO:0008408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008408", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "exonuclease activity", "id": "GO:0004527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004527", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "F1N5B5", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5B5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 410, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5B5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5B5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5B5" }, { "id": "SM00479", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Exonuclease", "eco_id": "ECO_0000259", "start_pos": 232, "end_pos": 393, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 43 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5F3-1", "uniprot_ac": "F1N5F3", "uniprot_id": "F1N5F3_BOVIN", "mass": { "chemical_mass": 16280.0, "monoisotopic_mass": 16280.0 }, "refseq": {}, "gene_names": [ { "name": "H2BK1", "type": "recommended", "evidence": [ { "id": "F1N5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ] } ], "protein_names": [ { "name": "Histone H2B", "type": "recommended", "evidence": [ { "id": "F1N5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "H2BK1", "url": "https://www.uniprot.org/uniprotkb/F1N5F3", "locus": { "chromosome": "4", "start_pos": 113780805, "end_pos": 113787677, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024204", "url": "https://www.ensembl.org/id/ENSBTAG00000024204" } ] } } ], "crossref": [ { "id": "F1N5F3", "url": "https://alphafold.ebi.ac.uk/entry/F1N5F3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023697", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023697", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22910", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22910", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5F3", "url": "https://www.orthodb.org/?gene=F1N5F3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5F3-1", "url": "https://www.uniprot.org/uniprotkb/F1N5F3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAEHGQLQQSGGRRGRSPGDKKSRRRSRRKETYSMYIYKVLKQVHPDIGISSKAMSIMNSFVNDLFERLAGEAARLAQYSGRTTLTSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKKKTGSGDLAQKLSSSPLVLCLHSLLL", "length": 148, "header": "tr|F1N5F3-1|F1N5F3_BOVIN Isoform 1 of Histone H2B OS=Bos taurus OX=9913 GN=H2BK1 PE=3 SV=4 CANONICAL=F1N5F3-1" }, "isoforms": [ { "isoform_ac": "F1N5F3-1", "url": "https://www.uniprot.org/uniprotkb/F1N5F3/entry", "sequence": { "sequence": "MSAEHGQLQQSGGRRGRSPGDKKSRRRSRRKETYSMYIYKVLKQVHPDIGISSKAMSIMNSFVNDLFERLAGEAARLAQYSGRTTLTSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKKKTGSGDLAQKLSSSPLVLCLHSLLL", "length": 148, "header": "tr|F1N5F3-1|F1N5F3_BOVIN Isoform 1 of Histone H2B OS=Bos taurus OX=9913 GN=H2BK1 PE=3 SV=4 CANONICAL=F1N5F3-1" }, "locus": { "chromosome": "4", "start_pos": 113785296, "end_pos": 113781809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033404.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033404.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033317.6", "url": "https://www.ensembl.org/id/ENSBTAP00000033317.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "F1N5F3", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5F3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 148, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5F3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5F3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5F3" }, { "id": "PF00125", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Core Histone H2A/H2B/H3", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 97, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5H6-1", "uniprot_ac": "F1N5H6", "uniprot_id": "F1N5H6_BOVIN", "mass": { "chemical_mass": 53333.0, "monoisotopic_mass": 53333.0 }, "refseq": {}, "gene_names": [ { "name": "GPR12", "type": "recommended", "evidence": [ { "id": "F1N5H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 12", "type": "synonym", "evidence": [ { "id": "F1N5H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR12", "url": "https://www.uniprot.org/uniprotkb/F1N5H6", "locus": { "chromosome": "12", "start_pos": 32875852, "end_pos": 32872209, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010769", "url": "https://www.ensembl.org/id/ENSBTAG00000010769" } ] } } ], "crossref": [ { "id": "F1N5H6", "url": "https://alphafold.ebi.ac.uk/entry/F1N5H6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010769", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010769", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15961", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15961", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5H6", "url": "https://www.orthodb.org/?gene=F1N5H6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22750", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22750", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N5H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGHGAPGRRCPAPAPCEPRVGCGAAAATVTLQFLASGSSRSHPAVGGSPRPRAQRSPDPWGARRPPGASAAARAGAVARAGGESERPGGESRAREPSPSLTCRRCSPGAERAPAFPARPSERPPPLAPRVRRRHATRVALWEQRRSPPPRPGRTKRTGVKMNEDPKVNVSGLPPEFVDAGASGNISAEVSSQVPVLQPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLIVNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLFMLWGTSICLGLLPVLGWNCLRDESTCSVVRPLTKNNAAILSVSFLFTFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGISTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLVCCGCVPPSLSQRARSPSDV", "length": 494, "header": "tr|F1N5H6-1|F1N5H6_BOVIN Isoform 1 of G protein-coupled receptor 12 OS=Bos taurus OX=9913 GN=GPR12 PE=3 SV=3 CANONICAL=F1N5H6-1" }, "isoforms": [ { "isoform_ac": "F1N5H6-1", "url": "https://www.uniprot.org/uniprotkb/F1N5H6/entry", "sequence": { "sequence": "MGHGAPGRRCPAPAPCEPRVGCGAAAATVTLQFLASGSSRSHPAVGGSPRPRAQRSPDPWGARRPPGASAAARAGAVARAGGESERPGGESRAREPSPSLTCRRCSPGAERAPAFPARPSERPPPLAPRVRRRHATRVALWEQRRSPPPRPGRTKRTGVKMNEDPKVNVSGLPPEFVDAGASGNISAEVSSQVPVLQPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLIVNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLFMLWGTSICLGLLPVLGWNCLRDESTCSVVRPLTKNNAAILSVSFLFTFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGISTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLVCCGCVPPSLSQRARSPSDV", "length": 494, "header": "tr|F1N5H6-1|F1N5H6_BOVIN Isoform 1 of G protein-coupled receptor 12 OS=Bos taurus OX=9913 GN=GPR12 PE=3 SV=3 CANONICAL=F1N5H6-1" }, "locus": { "chromosome": "12", "start_pos": 32874475, "end_pos": 32872298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014267.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014267.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014267.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014267.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ], "pmid": "" }, { "name": "phosphatidylcholine binding", "id": "GO:0031210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "database": "UniProtKB", "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1N5H6", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5H6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 494, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5H6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5H6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 461, "start_aa": "Glu", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 168, "end_pos": 170 }, { "start_pos": 184, "end_pos": 186 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5J4-1", "uniprot_ac": "F1N5J4", "uniprot_id": "F1N5J4_BOVIN", "mass": { "chemical_mass": 35756.0, "monoisotopic_mass": 35756.0 }, "refseq": { "ac": "NP_001377013", "name": "olfactory receptor family 51 subfamily A member 49", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377013" }, "gene_names": [ { "name": "OR51A49", "type": "recommended", "evidence": [ { "id": "F1N5J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" } ] }, { "name": "OR51A49", "type": "synonym", "evidence": [ { "id": "NP_001377013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377013" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N5J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5J4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 51 subfamily A member 49", "type": "synonym", "evidence": [ { "id": "NP_001377013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377013" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377013" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51A49", "url": "https://www.uniprot.org/uniprotkb/F1N5J4", "locus": { "chromosome": "15", "start_pos": 50370307, "end_pos": 50369345, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059483", "url": "https://www.ensembl.org/id/ENSBTAG00000059483" } ] } } ], "crossref": [ { "id": "F1N5J4", "url": "https://alphafold.ebi.ac.uk/entry/F1N5J4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050367", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050367", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526621", "url": "https://www.ncbi.nlm.nih.gov/gene/526621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526621", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526621", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF141", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF141", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377013", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5J4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIPSQSFNNISFFQPPAFLMIGIPGLEAIHGWISIPFSSMYTVALAGNCLILLAVRRTSSLHQPMYYFLSMLALTDMGLTLATMPTTLAVLWFDHRLISFNACLVQMFFLHYFSVVESSVLLAMSFDRFVAISNPLRYASVLTNNVIIRIGVGIVARATLSLFPVPFLLKRLNFCPNKTILSHSFCFHPDVMRRACADITINILYGLYVVVSTAGIDSLLIVLSYTFILCTVLGLASPRERIRALNTCVSHILAVLVFFIPVIGVSMIHRFGRHLPPIVHALVAYVYLGVPPVLNPVIYSVKSKPIREAMLWVLRRKCQS", "length": 320, "header": "tr|F1N5J4-1|F1N5J4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51A49 PE=3 SV=4 CANONICAL=F1N5J4-1" }, "isoforms": [ { "isoform_ac": "F1N5J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5J4/entry", "sequence": { "sequence": "MIPSQSFNNISFFQPPAFLMIGIPGLEAIHGWISIPFSSMYTVALAGNCLILLAVRRTSSLHQPMYYFLSMLALTDMGLTLATMPTTLAVLWFDHRLISFNACLVQMFFLHYFSVVESSVLLAMSFDRFVAISNPLRYASVLTNNVIIRIGVGIVARATLSLFPVPFLLKRLNFCPNKTILSHSFCFHPDVMRRACADITINILYGLYVVVSTAGIDSLLIVLSYTFILCTVLGLASPRERIRALNTCVSHILAVLVFFIPVIGVSMIHRFGRHLPPIVHALVAYVYLGVPPVLNPVIYSVKSKPIREAMLWVLRRKCQS", "length": 320, "header": "tr|F1N5J4-1|F1N5J4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51A49 PE=3 SV=4 CANONICAL=F1N5J4-1" }, "locus": { "chromosome": "15", "start_pos": 50370304, "end_pos": 50369345, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026212.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026212.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026212.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026212.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526621", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526621", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "F1N5J4", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5J4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 320, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5J4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5J4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5J4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 299, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5J5-1", "uniprot_ac": "F1N5J5", "uniprot_id": "F1N5J5_BOVIN", "mass": { "chemical_mass": 28984.0, "monoisotopic_mass": 28984.0 }, "refseq": {}, "gene_names": [ { "name": "RNF187", "type": "recommended", "evidence": [ { "id": "F1N5J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5J5" } ] } ], "protein_names": [ { "name": "Ring finger protein 187", "type": "synonym", "evidence": [ { "id": "F1N5J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5J5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5J5", "url": "https://www.uniprot.org/uniprotkb/F1N5J5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF187", "url": "https://www.uniprot.org/uniprotkb/F1N5J5", "locus": { "chromosome": "7", "start_pos": 2542859, "end_pos": 2546341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019667", "url": "https://www.ensembl.org/id/ENSBTAG00000019667" } ] } } ], "crossref": [ { "id": "F1N5J5", "url": "https://alphafold.ebi.ac.uk/entry/F1N5J5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019667", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019667", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5J5", "url": "https://www.orthodb.org/?gene=F1N5J5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1N5J5", "url": "https://www.uniprot.org/uniprotkb/F1N5J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5J5-1", "url": "https://www.uniprot.org/uniprotkb/F1N5J5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "CVRVPGSPSHQCAPVRIPVCALWGPAAAALALPAGPGEAACALCQSAPRDPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPSRPPLSRRLLALEEAAAAPTRDGPASEAALQLLCRADGGPLCAACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMKKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFAEEEGRFLQEAEKEEGSLEDEDEDPAERFRSLLQAVSELERRHRNLGLSMLLQ", "length": 264, "header": "tr|F1N5J5-1|F1N5J5_BOVIN Isoform 1 of Ring finger protein 187 OS=Bos taurus OX=9913 GN=RNF187 PE=4 SV=3 CANONICAL=F1N5J5-1" }, "isoforms": [ { "isoform_ac": "F1N5J5-1", "url": "https://www.uniprot.org/uniprotkb/F1N5J5/entry", "sequence": { "sequence": "CVRVPGSPSHQCAPVRIPVCALWGPAAAALALPAGPGEAACALCQSAPRDPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPSRPPLSRRLLALEEAAAAPTRDGPASEAALQLLCRADGGPLCAACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMKKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFAEEEGRFLQEAEKEEGSLEDEDEDPAERFRSLLQAVSELERRHRNLGLSMLLQ", "length": 264, "header": "tr|F1N5J5-1|F1N5J5_BOVIN Isoform 1 of Ring finger protein 187 OS=Bos taurus OX=9913 GN=RNF187 PE=4 SV=3 CANONICAL=F1N5J5-1" }, "locus": { "chromosome": "7", "start_pos": 2546232, "end_pos": 2543784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026211.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026211.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026211.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026211.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1N5J5", "url": "https://www.uniprot.org/uniprotkb/F1N5J5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5J5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5J5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5J5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5J5" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 81, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5K4-1", "uniprot_ac": "F1N5K4", "uniprot_id": "F1N5K4_BOVIN", "mass": { "chemical_mass": 15401.0, "monoisotopic_mass": 15401.0 }, "refseq": { "ac": "XP_024841821", "name": "biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841821" }, "gene_names": [ { "name": "BLOC1S2", "type": "recommended", "evidence": [ { "id": "F1N5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ] }, { "name": "BLOC1S2", "type": "synonym", "evidence": [ { "id": "XP_024841821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841821" } ] } ], "protein_names": [ { "name": "Biosis of lysosomal organelles complex 1 subunit 2", "type": "synonym", "evidence": [ { "id": "F1N5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K4/entry#names_and_taxonomy" } ] }, { "name": "biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024841821", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841821" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BLOC1S2", "url": "https://www.uniprot.org/uniprotkb/F1N5K4", "locus": { "chromosome": "26", "start_pos": 21174845, "end_pos": 21184563, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010739", "url": "https://www.ensembl.org/id/ENSBTAG00000010739" } ] } } ], "crossref": [ { "id": "F1N5K4", "url": "https://alphafold.ebi.ac.uk/entry/F1N5K4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010739", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010739", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519172", "url": "https://www.ncbi.nlm.nih.gov/gene/519172", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5K4", "url": "https://www.orthodb.org/?gene=F1N5K4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46479", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46479", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46479:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46479:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841821", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841821", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5K4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5K4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCPVGRPESPDDVAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINIIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR", "length": 135, "header": "tr|F1N5K4-1|F1N5K4_BOVIN Isoform 1 of Biosis of lysosomal organelles complex 1 subunit 2 OS=Bos taurus OX=9913 GN=BLOC1S2 PE=3 SV=4 CANONICAL=F1N5K4-1" }, "isoforms": [ { "isoform_ac": "F1N5K4-1", "url": "https://www.uniprot.org/uniprotkb/F1N5K4/entry", "sequence": { "sequence": "MKCPVGRPESPDDVAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINIIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR", "length": 135, "header": "tr|F1N5K4-1|F1N5K4_BOVIN Isoform 1 of Biosis of lysosomal organelles complex 1 subunit 2 OS=Bos taurus OX=9913 GN=BLOC1S2 PE=3 SV=4 CANONICAL=F1N5K4-1" }, "locus": { "chromosome": "26", "start_pos": 21184364, "end_pos": 21175284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014217.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014217.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014217.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014217.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "BLOC-1 complex", "id": "GO:0031083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031083", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "gamma-tubulin complex", "id": "GO:0000930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000930", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "anterograde synaptic vesicle transport", "id": "GO:0048490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048490", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:0008625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008625", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" }, { "name": "mitochondrial outer membrane permeabilization", "id": "GO:0097345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097345", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "F1N5K4", "url": "https://www.uniprot.org/uniprotkb/F1N5K4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5K4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 135, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5K4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5K4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5L8-1", "uniprot_ac": "F1N5L8", "uniprot_id": "F1N5L8_BOVIN", "mass": { "chemical_mass": 88209.0, "monoisotopic_mass": 88209.0 }, "refseq": {}, "gene_names": [ { "name": "SLITRK4", "type": "recommended", "evidence": [ { "id": "F1N5L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" } ] } ], "protein_names": [ { "name": "SLIT and NTRK like family member 4", "type": "synonym", "evidence": [ { "id": "F1N5L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5L8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5L8", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLITRK4", "url": "https://www.uniprot.org/uniprotkb/F1N5L8", "locus": { "chromosome": "X", "start_pos": 26759608, "end_pos": 26762121, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011780", "url": "https://www.ensembl.org/id/ENSBTAG00000011780" } ] } } ], "crossref": [ { "id": "F1N5L8", "url": "https://alphafold.ebi.ac.uk/entry/F1N5L8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011780", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011780", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CQERSIH", "url": "https://omabrowser.org/oma/group/CQERSIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N5L8", "url": "https://www.orthodb.org/?gene=F1N5L8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45773", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45773", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45773:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45773:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-388844", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-388844", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N5L8", "url": "https://www.uniprot.org/uniprotkb/F1N5L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5L8-1", "url": "https://www.uniprot.org/uniprotkb/F1N5L8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVEFCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKAPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPSNAKKLHVNGNSIKDVDISDFTEFEGLDLLHLGSNQITAIKGDVFRNLTNLRRLYLNGNQIERLYPEMFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQALTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVMKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPECGSMQLQLRKHDHKTNKKDGLGTEAFIPQTIEQMSKSHTCSLKDSETGFMFSDPPGQKVMMRNVTDKEKDVLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQDKKTKKSLIGGNHSKIVVEQRKSSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 785, "header": "tr|F1N5L8-1|F1N5L8_BOVIN Isoform 1 of SLIT and NTRK like family member 4 OS=Bos taurus OX=9913 GN=SLITRK4 PE=3 SV=3 CANONICAL=F1N5L8-1" }, "isoforms": [ { "isoform_ac": "F1N5L8-1", "url": "https://www.uniprot.org/uniprotkb/F1N5L8/entry", "sequence": { "sequence": "MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVEFCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKAPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPSNAKKLHVNGNSIKDVDISDFTEFEGLDLLHLGSNQITAIKGDVFRNLTNLRRLYLNGNQIERLYPEMFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQALTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVMKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPECGSMQLQLRKHDHKTNKKDGLGTEAFIPQTIEQMSKSHTCSLKDSETGFMFSDPPGQKVMMRNVTDKEKDVLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQDKKTKKSLIGGNHSKIVVEQRKSSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 785, "header": "tr|F1N5L8-1|F1N5L8_BOVIN Isoform 1 of SLIT and NTRK like family member 4 OS=Bos taurus OX=9913 GN=SLITRK4 PE=3 SV=3 CANONICAL=F1N5L8-1" }, "locus": { "chromosome": "X", "start_pos": 26762121, "end_pos": 26759611, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015639.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015639.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045371.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045371.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-388844", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-388844", "resource": "Reactome", "description": "Receptor-type tyrosine-protein phosphatases" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1N5L8", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1N5L8", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "F1N5L8", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "F1N5L8", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 671, "end_pos": 673, "annotation": "n_glycosylation_sequon" }, { "start_pos": 745, "end_pos": 747, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5L8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 785, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5L8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5L8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5L8" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 167, "end_pos": 211, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 273, "end_pos": 275 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 671, "end_pos": 673 }, { "start_pos": 745, "end_pos": 747 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5L9-1", "uniprot_ac": "F1N5L9", "uniprot_id": "F1N5L9_BOVIN", "mass": { "chemical_mass": 35472.0, "monoisotopic_mass": 35472.0 }, "refseq": { "ac": "XP_002690709", "name": "olfactory receptor 11H7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690709" }, "gene_names": [ { "name": "OR11H7", "type": "recommended", "evidence": [ { "id": "F1N5L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5L9" } ] }, { "name": "OR11H7", "type": "synonym", "evidence": [ { "id": "XP_002690709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690709" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1N5L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5L9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 11H7", "type": "synonym", "evidence": [ { "id": "XP_002690709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690709" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1N5L9", "url": "https://www.uniprot.org/uniprotkb/F1N5L9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5L9", "url": "https://www.uniprot.org/uniprotkb/F1N5L9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR11H7", "url": "https://www.uniprot.org/uniprotkb/F1N5L9", "locus": { "chromosome": "10", "start_pos": 26879265, "end_pos": 26880209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058766", "url": "https://www.ensembl.org/id/ENSBTAG00000058766" } ] } } ], "crossref": [ { "id": "F1N5L9", "url": "https://alphafold.ebi.ac.uk/entry/F1N5L9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032801", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032801", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15913", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15913", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783780", "url": "https://www.ncbi.nlm.nih.gov/gene/783780", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783780", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783780", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242:SF252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242:SF252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690709", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690709", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1N5L9", "url": "https://www.uniprot.org/uniprotkb/F1N5L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5L9-1", "url": "https://www.uniprot.org/uniprotkb/F1N5L9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNKSGISTVTQFVLLGFPGPWKMQIIFFSMILLIYILTLTGNIAIICAVRWHHQLHTPMYVFLANFSFLEIWYVTCTVPNMLVNFLSKTKTISFSGCFTQFYFFFSLGTTECFFLCVMAYDRYLAICRPLHYPTIMTGKLCAILVSLCWLTGFLGYSVPILFISQLPYCGPNIIDHFLCDVDPLMALSCASSPIIEHVFHSVSSLIIILTILYILGSYTLVLRAVFRVPSSAGRRKAFSTCGSHLVVVSLFYGTIMVMYVSPTSGNSVTMHKIITLIYSVVTPVLNPLIYSLRNRDMKFALRQVLCAMRIMQTS", "length": 314, "header": "tr|F1N5L9-1|F1N5L9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR11H7 PE=3 SV=4 CANONICAL=F1N5L9-1" }, "isoforms": [ { "isoform_ac": "F1N5L9-1", "url": "https://www.uniprot.org/uniprotkb/F1N5L9/entry", "sequence": { "sequence": "MNKSGISTVTQFVLLGFPGPWKMQIIFFSMILLIYILTLTGNIAIICAVRWHHQLHTPMYVFLANFSFLEIWYVTCTVPNMLVNFLSKTKTISFSGCFTQFYFFFSLGTTECFFLCVMAYDRYLAICRPLHYPTIMTGKLCAILVSLCWLTGFLGYSVPILFISQLPYCGPNIIDHFLCDVDPLMALSCASSPIIEHVFHSVSSLIIILTILYILGSYTLVLRAVFRVPSSAGRRKAFSTCGSHLVVVSLFYGTIMVMYVSPTSGNSVTMHKIITLIYSVVTPVLNPLIYSLRNRDMKFALRQVLCAMRIMQTS", "length": 314, "header": "tr|F1N5L9-1|F1N5L9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR11H7 PE=3 SV=4 CANONICAL=F1N5L9-1" }, "locus": { "chromosome": "10", "start_pos": 26880209, "end_pos": 26879268, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002208.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002208.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002208.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002208.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 263, "start_aa": "Thr", "end_pos": 263, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr263", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:783780", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783780", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1N5L9", "url": "https://www.uniprot.org/uniprotkb/F1N5L9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1N5L9", "url": "https://www.uniprot.org/uniprotkb/F1N5L9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1N5L9", "url": "https://www.uniprot.org/uniprotkb/F1N5L9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5L9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5L9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5L9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5L9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 263 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1N5M2-1", "uniprot_ac": "F1N5M2", "uniprot_id": "F1N5M2_BOVIN", "mass": { "chemical_mass": 53356.0, "monoisotopic_mass": 53356.0 }, "refseq": { "ac": "XP_005208149", "name": "vitamin D-binding protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208149" }, "gene_names": [ { "name": "GC", "type": "recommended", "evidence": [ { "id": "F1N5M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ] }, { "name": "GC", "type": "synonym", "evidence": [ { "id": "XP_005208149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208149" } ] } ], "protein_names": [ { "name": "Vitamin D-binding protein", "type": "recommended", "evidence": [ { "id": "F1N5M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5M2/entry#names_and_taxonomy" } ] }, { "name": "Gc-globulin", "type": "synonym", "evidence": [ { "id": "F1N5M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5M2/entry#names_and_taxonomy" } ] }, { "name": "Group-specific component", "type": "synonym", "evidence": [ { "id": "F1N5M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5M2/entry#names_and_taxonomy" } ] }, { "name": "vitamin D-binding protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208149", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208149" } ] } ], "function": [ { "annotation": "Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2#function" }, { "database": "UniProtKB", "id": "ARBA00002354", "url": "https://www.uniprot.org/uniprotkb/ARBA00002354#function" }, { "database": "UniProtKB", "id": "A0A3Q1LQ02", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ02#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GC", "url": "https://www.uniprot.org/uniprotkb/F1N5M2", "locus": { "chromosome": "6", "start_pos": 86963822, "end_pos": 87007062, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013718", "url": "https://www.ensembl.org/id/ENSBTAG00000013718" } ] } } ], "crossref": [ { "id": "F1N5M2", "url": "https://alphafold.ebi.ac.uk/entry/F1N5M2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013718", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013718", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00015", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00015", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530076", "url": "https://www.ncbi.nlm.nih.gov/gene/530076", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000264", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000264", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5M2", "url": "https://www.orthodb.org/?gene=F1N5M2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11385:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11385:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09164", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09164", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196791", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196791", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005208149", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208149", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ02", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ02-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5M2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5M2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRILVFLLAVAFVHALERGRDYEKDKVCKDLASLGRDDFTSLSMVLYSRKFPSGTFEQISHLVNEVVSLTVTCCAEGADPDCYDNRTSALSDKSCESNSPFPVHPGTPECCTHEGLEKKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKDFADRFMYEYSINYGQAPLTLLVGYTKSYLSMVGSCCTSPNPTVCFLKERLQLKHFSLLTIMTNRICSQYAAYGKEKSRLSHLIKFAQKVPTAHLEDVLPLAEDITTILSKCCDSVSEDCIKELPEYAVKLCDNLSTKNSKFKDCCQEKTPMEIFVCAYFMPASPNPELPDVKLPMNKDVCDEGNTKVLDQYIFELSRKTRIPEVFLTKILESTLKSLDECCHSESSTACLNAKGPQLTRELSSFIQKGQELCADYSENTFTEYKKKLAERLRGKFPDATETDLQELVAKRSDFASKCCSVNSPPLYCNSEIDAEINTLQS", "length": 474, "header": "tr|F1N5M2-1|F1N5M2_BOVIN Isoform 1 of Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=4 SV=2 CANONICAL=F1N5M2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ02-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ02/entry", "sequence": { "sequence": "MKRILVFLLAVAFVHALERGKISSAVTICKNFHYMFIFLLRSMVLYSRKFPSGTFEQISHLVNEVVSLTVTCCAEGADPDCYDNRTSALSDKSCESNSPFPVHPGTPECCTHEGLEKKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKDFADRFMYEYSINYGQAPLTLLVGYTKSYLSMVGSCCTSPNPTVCFLKERLQLKHFSLLTIMTNRICSQYAAYGKEKSRLSHLIKFAQKVPTAHLEDVLPLAEDITTILSKCCDSVSEDCIKELPEYAVKLCDNLSTKNSKFKDCCQEKTPMEIFVCAYFMPASPNPELPDVKLPMNKDVCDEGNTKVLDQYIFELSRKTRIPEVFLTKILESTLKSLDECCHSESSTACLNAKGPQLTRELSSFIQKGQELCADYSENTFTEYKKKLAERLRGKFPDATETDLQELVAKRSDFASKCCSVNSPPLYCNSEVRKFTVLLITA", "length": 473, "header": "tr|A0A3Q1LQ02-1|A0A3Q1LQ02_BOVIN Computationally mapped isoform of Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=4 SV=2 CANONICAL=F1N5M2-1" }, "locus": { "chromosome": "6", "start_pos": 87006998, "end_pos": 86975609, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075079.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075079.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062210.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062210.2" } ] } }, { "isoform_ac": "F1N5M2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5M2/entry", "sequence": { "sequence": "MKRILVFLLAVAFVHALERGRDYEKDKVCKDLASLGRDDFTSLSMVLYSRKFPSGTFEQISHLVNEVVSLTVTCCAEGADPDCYDNRTSALSDKSCESNSPFPVHPGTPECCTHEGLEKKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKDFADRFMYEYSINYGQAPLTLLVGYTKSYLSMVGSCCTSPNPTVCFLKERLQLKHFSLLTIMTNRICSQYAAYGKEKSRLSHLIKFAQKVPTAHLEDVLPLAEDITTILSKCCDSVSEDCIKELPEYAVKLCDNLSTKNSKFKDCCQEKTPMEIFVCAYFMPASPNPELPDVKLPMNKDVCDEGNTKVLDQYIFELSRKTRIPEVFLTKILESTLKSLDECCHSESSTACLNAKGPQLTRELSSFIQKGQELCADYSENTFTEYKKKLAERLRGKFPDATETDLQELVAKRSDFASKCCSVNSPPLYCNSEIDAEINTLQS", "length": 474, "header": "tr|F1N5M2-1|F1N5M2_BOVIN Isoform 1 of Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=4 SV=2 CANONICAL=F1N5M2-1" }, "locus": { "chromosome": "6", "start_pos": 87006998, "end_pos": 86968892, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033473.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033473.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033386.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033386.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-196791", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196791", "resource": "Reactome", "description": "Vitamin D (calciferol) metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "vitamin transmembrane transporter activity", "id": "GO:0090482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090482", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" }, { "name": "calcidiol binding", "id": "GO:1902118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902118", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" }, { "name": "vitamin D binding", "id": "GO:0005499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005499", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vitamin D metabolic process", "id": "GO:0042359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042359", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" }, { "name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "F1N5M2", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1N5M2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 474, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1N5M2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1N5M2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1N5M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5M2" }, { "id": "PS51438", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51438" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Albumin", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 208, "start_aa": "Ala", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 287, "end_pos": 289 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } } ]